## Wed Feb 12 16:34:30 2025
## emapper-2.1.12
## /data/home/zhuyingjie/miniforge3/envs/eggnog/bin/emapper.py -i /data/shared_data/ZYJ_Metagenome/metagenome_bucong/mmseqs/SRR24130645//SRR24130645_p_cluster_rep_seq.fasta --output SRR24130645 --data_dir /data/software/eggnog_database -m diamond --sensmode fast --output_dir /data/shared_data/ZYJ_Metagenome/metagenome_bucong/eggnog/SRR24130645 --temp_dir /data/software/eggnog_database/temp --excel --dbmem --cpu 24
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
k141_1172_1	457425.XNR_2158	1.94e-09	65.1	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria	201174|Actinobacteria	I	Belongs to the thiolase family	paaJ	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k141_994_1	1121468.AUBR01000034_gene1377	1.19e-88	281.0	COG0365@1|root,COG0365@2|Bacteria,1TQTI@1239|Firmicutes,24E00@186801|Clostridia,42FQ1@68295|Thermoanaerobacterales	1239|Firmicutes	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	-	-	6.2.1.16	ko:K01907	ko00280,ko00650,map00280,map00650	-	R01357	RC00004,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k141_364_1	643867.Ftrac_1021	3.76e-25	103.0	COG1305@1|root,COG1305@2|Bacteria,4NGQG@976|Bacteroidetes,47UXE@768503|Cytophagia	976|Bacteroidetes	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
k141_1357_1	765952.PUV_12820	1.46e-153	442.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5,DDE_Tnp_1
k141_1357_2	1231626.CAHE_0816	7.67e-198	559.0	COG3328@1|root,COG3328@2|Bacteria,4NFQS@976|Bacteroidetes,47JYB@768503|Cytophagia	976|Bacteroidetes	L	PFAM Transposase, Mutator family	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k141_2525_1	1089553.Tph_c22180	4.06e-22	94.7	COG3039@1|root,COG3039@2|Bacteria,1TRBK@1239|Firmicutes,24DZ0@186801|Clostridia,42JAE@68295|Thermoanaerobacterales	186801|Clostridia	L	Transposase domain (DUF772)	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
k141_1173_1	469618.FVAG_00688	1.57e-72	233.0	COG2368@1|root,COG2368@2|Bacteria,379E7@32066|Fusobacteria	32066|Fusobacteria	Q	4-hydroxyphenylacetate 3-hydroxylase C terminal	abfD	-	4.2.1.120,5.3.3.3	ko:K14534	ko00650,ko00720,ko01100,ko01120,ko01200,map00650,map00720,map01100,map01120,map01200	M00374,M00375	R03031,R10782	RC01857,RC03277	ko00000,ko00001,ko00002,ko01000	-	-	-	HpaB,HpaB_N
k141_1084_1	411476.BACOVA_05242	8.56e-23	102.0	COG1148@1|root,COG1148@2|Bacteria,4NI95@976|Bacteroidetes,2FRRV@200643|Bacteroidia,4ANZK@815|Bacteroidaceae	976|Bacteroidetes	C	Glucose inhibited division protein A	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Fer4,Fer4_7,HI0933_like,Pyr_redox_2
k141_453_1	1129794.C427_2709	1.44e-29	115.0	COG3386@1|root,COG3386@2|Bacteria,1QN8Y@1224|Proteobacteria,1S5PU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	SMP-30/Gluconolaconase/LRE-like region	-	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	SGL
k141_184_2	1196028.ALEF01000031_gene1285	4.16e-26	109.0	COG0642@1|root,COG2205@2|Bacteria,1V10X@1239|Firmicutes,4HB4P@91061|Bacilli,4C4PX@84406|Virgibacillus	91061|Bacilli	T	His Kinase A (phosphoacceptor) domain	hssS	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
k141_724_1	439481.Aboo_0728	4.23e-32	128.0	COG0008@1|root,arCOG00402@2157|Archaea,2XSUM@28890|Euryarchaeota,3F2FR@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF692.Mbar_A0179	HGTP_anticodon,ProRS-C_1,ProRS-C_2,tRNA-synt_2b
k141_274_1	1047013.AQSP01000114_gene705	1.19e-193	546.0	COG3385@1|root,COG3385@2|Bacteria,2NQNF@2323|unclassified Bacteria	2|Bacteria	L	Domain of unknown function (DUF4372)	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4372
k141_815_1	931626.Awo_c27940	4.45e-10	66.2	COG5598@1|root,COG5598@2|Bacteria,1UZB8@1239|Firmicutes,24FJK@186801|Clostridia,25Y4Q@186806|Eubacteriaceae	186801|Clostridia	H	Trimethylamine methyltransferase (MTTB)	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
k141_546_1	869209.Tresu_1277	2.47e-18	88.6	COG5581@1|root,COG5581@2|Bacteria,2J6AM@203691|Spirochaetes	203691|Spirochaetes	M	Type IV pilus assembly	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
k141_1803_1	96561.Dole_1685	5.33e-86	271.0	COG1775@1|root,COG1775@2|Bacteria,1NKED@1224|Proteobacteria,42NFZ@68525|delta/epsilon subdivisions,2WMBX@28221|Deltaproteobacteria,2MNG5@213118|Desulfobacterales	28221|Deltaproteobacteria	E	PFAM 2-hydroxyglutaryl-CoA dehydratase, D-component	-	-	-	-	-	-	-	-	-	-	-	-	HGD-D
k141_637_1	10224.XP_002741068.2	2.54e-43	158.0	COG0028@1|root,KOG1185@2759|Eukaryota,38EFU@33154|Opisthokonta,3BEH9@33208|Metazoa,3D030@33213|Bilateria	33208|Metazoa	EH	acetolactate synthase)-like	ILVBL	GO:0001501,GO:0005575,GO:0007275,GO:0008150,GO:0009653,GO:0009790,GO:0009792,GO:0009887,GO:0016020,GO:0032501,GO:0032502,GO:0043009,GO:0048513,GO:0048562,GO:0048568,GO:0048598,GO:0048701,GO:0048704,GO:0048705,GO:0048706,GO:0048731,GO:0048856,GO:1904888	-	ko:K11259	-	-	-	-	ko00000,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k141_1623_1	177437.HRM2_11720	6.62e-24	97.4	COG1908@1|root,COG1908@2|Bacteria,1RCZY@1224|Proteobacteria,42RJZ@68525|delta/epsilon subdivisions,2WND6@28221|Deltaproteobacteria,2MK4Q@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Methyl-viologen-reducing hydrogenase, delta subunit	-	-	1.8.98.5,1.8.98.6	ko:K14127	ko00680,map00680	-	R00019,R11943,R11944	RC00011	ko00000,ko00001,ko01000	-	-	-	FlpD
k141_1989_1	880072.Desac_2171	9.27e-54	192.0	COG0417@1|root,COG0417@2|Bacteria	2|Bacteria	L	DNA replication proofreading	polB	-	2.7.7.7	ko:K02336,ko:K06877	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	CarbopepD_reg_2,DNA_pol_B,DNA_pol_B_exo1,RNase_H_2
k141_96_1	444157.Tneu_1975	2.61e-61	202.0	COG1812@1|root,arCOG01678@2157|Archaea,2XPSB@28889|Crenarchaeota	28889|Crenarchaeota	H	Catalyzes the formation of S-adenosylmethionine from methionine and ATP	mat	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_Synthase
k141_2347_1	749222.Nitsa_0814	4.67e-49	168.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,42NMG@68525|delta/epsilon subdivisions,2YMVR@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	E	Abc transporter	livG	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
k141_1358_1	459349.CLOAM0147	7.04e-72	220.0	28PU3@1|root,2ZCF5@2|Bacteria	2|Bacteria	S	MjaI restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	RE_MjaI
k141_275_1	1184251.TCELL_1141	1.33e-42	151.0	COG1184@1|root,arCOG01124@2157|Archaea,2XPZN@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eIF-2B alpha beta delta subunits family	-	-	5.3.1.29	ko:K18237	-	-	-	-	ko00000,ko01000	-	-	-	IF-2B
k141_725_1	1158345.JNLL01000001_gene971	5.51e-40	148.0	COG0188@1|root,COG1372@1|root,COG0188@2|Bacteria,COG1372@2|Bacteria,2G3MH@200783|Aquificae	200783|Aquificae	L	DNA gyrase topoisomerase IV, subunit A	gyrA	GO:0005575,GO:0005622,GO:0005623,GO:0009330,GO:0032991,GO:0044424,GO:0044464	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV,Intein_splicing,LAGLIDADG_3
k141_725_2	1540257.JQMW01000011_gene1672	3.96e-24	92.4	2BAPB@1|root,32448@2|Bacteria,1UQGX@1239|Firmicutes,24TXP@186801|Clostridia,36NES@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_2526_1	1056495.Calag_0343	3.77e-11	63.9	COG3199@1|root,arCOG01350@2157|Archaea,2XPMG@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM ATP-NAD AcoX kinase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_kinase
k141_2526_2	1128398.Curi_c22970	1.65e-63	201.0	COG0500@1|root,COG0500@2|Bacteria,1TS1P@1239|Firmicutes,24DMF@186801|Clostridia	186801|Clostridia	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k141_366_1	7668.SPU_028323-tr	2.13e-47	159.0	2BG5J@1|root,2S18N@2759|Eukaryota,3A435@33154|Opisthokonta,3BRGG@33208|Metazoa,3D8KM@33213|Bilateria	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_817_1	1122176.KB903531_gene3073	5e-09	62.4	COG2312@1|root,COG2312@2|Bacteria,4PP0J@976|Bacteroidetes	976|Bacteroidetes	E	CotH kinase protein	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1,CotH,LTD
k141_97_1	511051.CSE_07000	4.33e-09	58.2	COG1418@1|root,COG1418@2|Bacteria	2|Bacteria	S	mRNA catabolic process	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
k141_97_2	1005057.BUAMB_010	2.38e-16	79.7	COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,1RNB2@1236|Gammaproteobacteria,37CZZ@32199|Buchnera	1236|Gammaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009330,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0032991,GO:0034335,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:0140097,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k141_905_1	536233.CLO_3149	3.15e-49	172.0	COG1018@1|root,COG1018@2|Bacteria,1TRG2@1239|Firmicutes,24CTI@186801|Clostridia,36EJ1@31979|Clostridiaceae	186801|Clostridia	C	Oxidoreductase FAD-binding domain	-	-	1.14.12.17	ko:K05916	ko05132,map05132	-	-	-	ko00000,ko00001,ko01000	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
k141_1359_1	1121448.DGI_2662	2.91e-21	99.8	COG3852@1|root,COG4191@1|root,COG3852@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,2M97J@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,sCache_2
k141_1718_1	316067.Geob_2122	5.44e-12	63.2	COG0614@1|root,COG0614@2|Bacteria,1N7EM@1224|Proteobacteria,42W76@68525|delta/epsilon subdivisions,2WSHJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
k141_1085_1	585.DR95_2204	1.03e-48	181.0	COG1882@1|root,COG1882@2|Bacteria,1MWBF@1224|Proteobacteria,1RMEK@1236|Gammaproteobacteria,3Z17P@583|Proteus	1236|Gammaproteobacteria	C	Glycine radical enzyme that catalyzes the cleavage of a C-N bond in choline, producing trimethylamine (TMA) and acetaldehyde	pflB	-	2.3.1.54,4.3.99.4	ko:K00656,ko:K20038	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
k141_1534_1	679926.Mpet_0422	6.68e-46	165.0	COG0129@1|root,arCOG04045@2157|Archaea,2XSW2@28890|Euryarchaeota,2N992@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the IlvD Edd family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2069	ILVD_EDD
k141_1264_1	289376.THEYE_A1149	9.13e-55	187.0	COG1902@1|root,COG1902@2|Bacteria,3J14N@40117|Nitrospirae	40117|Nitrospirae	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	-	ko:K10680	ko00633,ko01120,map00633,map01120	-	R08014,R08017,R08042	RC00250	ko00000,ko00001,ko01000	-	-	-	Oxidored_FMN
k141_818_1	38833.XP_003061902.1	3.99e-68	220.0	COG0162@1|root,KOG2144@2759|Eukaryota,37ICN@33090|Viridiplantae,34JRD@3041|Chlorophyta	3041|Chlorophyta	J	Belongs to the class-I aminoacyl-tRNA synthetase family	-	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	tRNA-synt_1b
k141_2259_1	502025.Hoch_5959	9.42e-46	159.0	COG5421@1|root,COG5421@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2
k141_98_1	1150599.MPHLEI_10294	1.35e-35	133.0	COG0502@1|root,COG0502@2|Bacteria,2I2Q1@201174|Actinobacteria,236A1@1762|Mycobacteriaceae	201174|Actinobacteria	H	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
k141_1175_2	391009.Tmel_0618	2.18e-31	114.0	COG3862@1|root,COG3862@2|Bacteria,2GD7F@200918|Thermotogae	200918|Thermotogae	S	protein with conserved CXXC pairs	-	-	-	-	-	-	-	-	-	-	-	-	DUF1667
k141_997_1	1047013.AQSP01000134_gene1338	2.37e-54	186.0	COG5598@1|root,COG5598@2|Bacteria,2NQTC@2323|unclassified Bacteria	2|Bacteria	H	Trimethylamine methyltransferase (MTTB)	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
k141_1360_1	443143.GM18_2882	1.98e-25	105.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria	1224|Proteobacteria	L	reverse transcriptase	-	-	2.7.7.49	ko:K00986	-	-	-	-	ko00000,ko01000	-	-	-	GIIM,HNH,RVT_1,RVT_N
k141_2169_1	759914.BP951000_1611	5.45e-69	219.0	COG0191@1|root,COG0191@2|Bacteria,2J5IR@203691|Spirochaetes	203691|Spirochaetes	G	aldolase class II	fba	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
k141_906_1	67593.Physo108913	5.8e-35	135.0	COG0045@1|root,KOG1254@2759|Eukaryota,3QC2F@4776|Peronosporales	4776|Peronosporales	C	ATP citrate lyase citrate-binding	-	-	2.3.3.8	ko:K01648	ko00020,ko00720,ko01100,ko01110,ko01120,ko01130,map00020,map00720,map01100,map01110,map01120,map01130	-	R00352	RC00004,RC00067	ko00000,ko00001,ko01000,ko04147	-	-	-	Citrate_bind,Citrate_synt,CoA_binding,Ligase_CoA
k141_906_2	29730.Gorai.008G159900.1	1.4e-40	147.0	COG0045@1|root,KOG1254@2759|Eukaryota,37IP2@33090|Viridiplantae,3GCZE@35493|Streptophyta	35493|Streptophyta	C	ATP-citrate synthase alpha chain protein	ACLA-1	GO:0003674,GO:0003824,GO:0003878,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006084,GO:0006085,GO:0006139,GO:0006163,GO:0006164,GO:0006629,GO:0006631,GO:0006633,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009346,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0032991,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046394,GO:0046483,GO:0046912,GO:0051186,GO:0051188,GO:0055086,GO:0071616,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.3.3.8	ko:K01648	ko00020,ko00720,ko01100,ko01110,ko01120,ko01130,map00020,map00720,map01100,map01110,map01120,map01130	-	R00352	RC00004,RC00067	ko00000,ko00001,ko01000,ko04147	-	-	-	ATP-grasp_2,Citrate_bind
k141_1195_1	273063.STK_17980	2.35e-15	76.3	COG1545@1|root,arCOG01287@2157|Archaea,2XQMR@28889|Crenarchaeota	28889|Crenarchaeota	S	Rubredoxin-like zinc ribbon domain (DUF35_N)	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
k141_660_1	189753.AXAS01000063_gene3512	5.72e-53	174.0	COG3464@1|root,COG3464@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3
k141_1641_1	1117379.BABA_20406	5.15e-32	128.0	COG2217@1|root,COG2217@2|Bacteria,1TQ07@1239|Firmicutes,4H9SP@91061|Bacilli,1ZAPS@1386|Bacillus	91061|Bacilli	P	COG2217 Cation transport ATPase	zosA	-	3.6.3.3,3.6.3.5	ko:K01534	-	-	-	-	ko00000,ko01000	3.A.3.6	-	-	E1-E2_ATPase,Hydrolase
k141_2829_2	1120977.JHUX01000003_gene843	1.03e-07	59.7	COG3935@1|root,COG3935@2|Bacteria,1NIEW@1224|Proteobacteria	1224|Proteobacteria	L	DnaD domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_1551_1	305900.GV64_23975	1.84e-18	89.7	COG0493@1|root,COG1145@1|root,COG0493@2|Bacteria,COG1145@2|Bacteria,1MU2H@1224|Proteobacteria,1RMY7@1236|Gammaproteobacteria,1XIGF@135619|Oceanospirillales	135619|Oceanospirillales	E	glutamate synthase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_20,Pyr_redox_2,Pyr_redox_3
k141_1196_1	1121445.ATUZ01000011_gene824	1.71e-25	110.0	COG3170@1|root,COG3170@2|Bacteria,1QZU8@1224|Proteobacteria,43CP9@68525|delta/epsilon subdivisions,2X7WK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NU	Tfp pilus assembly protein FimV	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_1015_1	224325.AF_1241	7.83e-33	129.0	COG0001@1|root,arCOG00918@2157|Archaea,2XTRI@28890|Euryarchaeota,245Z9@183980|Archaeoglobi	183980|Archaeoglobi	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k141_1381_4	1417599.U6C697_9CAUD	1.29e-37	151.0	4QBFN@10239|Viruses,4QXWN@35237|dsDNA viruses  no RNA stage,4QPTW@28883|Caudovirales,4QNPZ@10744|Podoviridae	10744|Podoviridae	S	Phage stabilisation protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_1478_1	376686.Fjoh_4099	6.44e-30	122.0	COG1554@1|root,COG1554@2|Bacteria,4NHVP@976|Bacteroidetes,1I87C@117743|Flavobacteriia,2NU01@237|Flavobacterium	976|Bacteroidetes	G	hydrolase, family 65, central catalytic	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_925_1	1026970.XP_008824872.1	1.22e-57	196.0	COG2036@1|root,COG5262@1|root,KOG1745@2759|Eukaryota,KOG1756@2759|Eukaryota,KOG3467@2759|Eukaryota,39ZTV@33154|Opisthokonta,3BPDH@33208|Metazoa,3D6BK@33213|Bilateria,48E1W@7711|Chordata,49B7M@7742|Vertebrata,3JEM2@40674|Mammalia,35PS8@314146|Euarchontoglires	33208|Metazoa	B	Histone cluster 1	HIST1H3D	GO:0000228,GO:0000785,GO:0000786,GO:0000788,GO:0000790,GO:0003674,GO:0003676,GO:0003677,GO:0003682,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005694,GO:0006323,GO:0006325,GO:0006333,GO:0006334,GO:0006335,GO:0006996,GO:0008150,GO:0009987,GO:0010468,GO:0016043,GO:0019222,GO:0022607,GO:0031490,GO:0031491,GO:0031492,GO:0031497,GO:0031974,GO:0031981,GO:0032991,GO:0032993,GO:0034622,GO:0034723,GO:0034728,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043933,GO:0044085,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044454,GO:0044464,GO:0044815,GO:0044877,GO:0050789,GO:0050794,GO:0051259,GO:0051262,GO:0051276,GO:0051290,GO:0051291,GO:0060255,GO:0060968,GO:0065003,GO:0065004,GO:0065007,GO:0070013,GO:0071103,GO:0071824,GO:0071840,GO:0097159,GO:1901363	-	ko:K11253,ko:K11254	ko05034,ko05202,ko05203,ko05322,map05034,map05202,map05203,map05322	-	-	-	ko00000,ko00001,ko03036,ko04147	-	-	-	CENP-T_C,Histone,Histone_H2A_C
k141_2458_2	696281.Desru_1096	2.49e-11	64.3	COG3405@1|root,COG3405@2|Bacteria,1VBUA@1239|Firmicutes,24WR1@186801|Clostridia	186801|Clostridia	G	Belongs to the glycosyl hydrolase 8 (cellulase D) family	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_572_1	243232.MJ_1261	4.66e-75	241.0	COG3276@1|root,arCOG01563@2157|Archaea,2XUKU@28890|Euryarchaeota,23QPD@183939|Methanococci	183939|Methanococci	J	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA	eif2g	-	-	ko:K03242	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,eIF2_C
k141_2830_1	1217715.F994_02576	1.21e-31	127.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,1RMGJ@1236|Gammaproteobacteria,3NPIS@468|Moraxellaceae	1236|Gammaproteobacteria	Q	Flavin containing amine oxidoreductase	-	-	5.2.1.13	ko:K09835	ko00906,ko01100,ko01110,map00906,map01100,map01110	M00097	R07512	RC01960	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase,NAD_binding_8
k141_1918_1	522772.Dacet_2958	3.53e-42	153.0	COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,2GEXW@200930|Deferribacteres	200930|Deferribacteres	E	Chorismate mutase type II	-	-	4.2.1.51,5.4.99.5	ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R00691,R01373,R01715	RC00360,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,CM_2,PDT
k141_2831_1	448385.sce4770	7.36e-52	175.0	COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,42MDR@68525|delta/epsilon subdivisions,2WKUR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k141_293_1	237368.SCABRO_01673	4.08e-45	160.0	COG0582@1|root,COG0582@2|Bacteria,2J4Y0@203682|Planctomycetes	203682|Planctomycetes	L	Putative transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp
k141_2096_1	1232437.KL662007_gene1686	6.48e-147	418.0	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,42UXI@68525|delta/epsilon subdivisions,2WQST@28221|Deltaproteobacteria,2MKNI@213118|Desulfobacterales	28221|Deltaproteobacteria	L	DNA breaking-rejoining enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
k141_204_1	1487921.DP68_13055	1.54e-08	61.6	COG1269@1|root,COG1269@2|Bacteria,1TPTE@1239|Firmicutes,249YV@186801|Clostridia,36EI6@31979|Clostridiaceae	186801|Clostridia	U	Belongs to the V-ATPase 116 kDa subunit family	ntpI	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
k141_1554_1	1167006.UWK_03157	7.39e-38	148.0	COG1148@1|root,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MIJ3@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Pyridine nucleotide-disulphide oxidoreductase	bamE	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_7,NAD_binding_8,Pyr_redox_2
k141_1740_1	1235792.C808_01622	1.72e-31	131.0	COG4974@1|root,COG4974@2|Bacteria,1TQST@1239|Firmicutes,247YT@186801|Clostridia,27KQG@186928|unclassified Lachnospiraceae	186801|Clostridia	L	Transposase IS66 family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
k141_2459_1	1122172.KB890259_gene918	4.78e-05	50.8	COG0170@1|root,COG0170@2|Bacteria,37C6R@32066|Fusobacteria	32066|Fusobacteria	I	Psort location CytoplasmicMembrane, score 10.00	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_478_1	1048983.EL17_06550	6.65e-11	67.0	COG1211@1|root,COG1211@2|Bacteria,4NMB5@976|Bacteroidetes,47P6K@768503|Cytophagia	976|Bacteroidetes	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	GO:0003674,GO:0003824,GO:0016740,GO:0016772,GO:0016779,GO:0050518,GO:0070567	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
k141_478_3	649747.HMPREF0083_00997	1.68e-25	100.0	COG3405@1|root,COG3405@2|Bacteria,1VBUA@1239|Firmicutes,4HMXV@91061|Bacilli,26Z1A@186822|Paenibacillaceae	91061|Bacilli	G	Belongs to the glycosyl hydrolase 8 (cellulase D) family	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_316_2	386456.JQKN01000001_gene2186	4.34e-38	139.0	COG1104@1|root,arCOG00066@2157|Archaea,2Y7J8@28890|Euryarchaeota,23NPK@183925|Methanobacteria	183925|Methanobacteria	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
k141_776_1	96561.Dole_2191	2.48e-74	251.0	COG1882@1|root,COG1882@2|Bacteria,1MWBF@1224|Proteobacteria,42M5J@68525|delta/epsilon subdivisions,2WJAK@28221|Deltaproteobacteria,2MI4X@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM formate C-acetyltransferase glycine radical	-	-	2.3.1.54,4.3.99.4	ko:K00656,ko:K20038	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
k141_1511_2	1499967.BAYZ01000137_gene110	1.05e-32	123.0	COG1600@1|root,COG1600@2|Bacteria	2|Bacteria	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	-	-	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Fer4_16
k141_2392_1	985665.HPL003_04245	6.77e-84	274.0	COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,4HAW9@91061|Bacilli,26SMJ@186822|Paenibacillaceae	91061|Bacilli	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k141_1848_1	159749.K0T6U0	1.33e-53	191.0	COG2801@1|root,2QT1S@2759|Eukaryota	2759|Eukaryota	L	transposition	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1,rve
k141_142_1	1094980.Mpsy_2727	1.65e-53	179.0	COG1500@1|root,arCOG04187@2157|Archaea,2XTNH@28890|Euryarchaeota,2N9D8@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM Shwachman-Bodian-Diamond syndrome	-	-	-	ko:K14574	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	SBDS,SBDS_C
k141_2309_1	309799.DICTH_0877	1.07e-47	171.0	COG0449@1|root,COG0449@2|Bacteria	2|Bacteria	M	glutamine-fructose-6-phosphate transaminase (isomerizing) activity	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006002,GO:0006040,GO:0006047,GO:0006048,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009226,GO:0009987,GO:0016020,GO:0016740,GO:0016769,GO:0018130,GO:0019438,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0034654,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046349,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	iAF987.Gmet_1487,iE2348C_1286.E2348C_4039,iEC042_1314.EC042_4115,iECIAI39_1322.ECIAI39_4333,iECNA114_1301.ECNA114_3878,iECOK1_1307.ECOK1_4178,iECSF_1327.ECSF_3577,iECUMN_1333.ECUMN_4259,iEcSMS35_1347.EcSMS35_4097,iIT341.HP1532,iLF82_1304.LF82_0844,iNJ661.Rv3436c,iNRG857_1313.NRG857_18570,iSB619.SA_RS11245,iSFV_1184.SFV_3755,iSF_1195.SF3809,iSFxv_1172.SFxv_4151,iS_1188.S3959,iUMN146_1321.UM146_18835,iUTI89_1310.UTI89_C4281,iYO844.BSU01780	GATase_6,SIS
k141_44_1	1408306.JHXX01000001_gene1661	1.37e-56	192.0	COG2195@1|root,COG2195@2|Bacteria,1TP3A@1239|Firmicutes,248JJ@186801|Clostridia,4BXUP@830|Butyrivibrio	186801|Clostridia	E	Peptidase dimerisation domain	pepT	-	3.4.11.4	ko:K01258	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
k141_1212_1	391623.TERMP_01002	2.66e-108	328.0	COG0015@1|root,arCOG01747@2157|Archaea,2XUQ5@28890|Euryarchaeota,24385@183968|Thermococci	183968|Thermococci	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
k141_2209_1	98439.AJLL01000090_gene71	3.9e-21	97.8	COG0642@1|root,COG0784@1|root,COG2199@1|root,COG2202@1|root,COG2203@1|root,COG4251@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG3706@2|Bacteria,COG4251@2|Bacteria,1G09B@1117|Cyanobacteria,1JKNQ@1189|Stigonemataceae	1117|Cyanobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K11527	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
k141_2123_1	469383.Cwoe_2497	3.98e-13	74.3	COG1788@1|root,COG2057@1|root,COG1788@2|Bacteria,COG2057@2|Bacteria,2GMA1@201174|Actinobacteria,4CSHF@84995|Rubrobacteria	84995|Rubrobacteria	I	Coenzyme A transferase	-	-	-	-	-	-	-	-	-	-	-	-	CoA_trans
k141_1947_1	679926.Mpet_0203	6.55e-06	53.5	COG3291@1|root,arCOG02521@1|root,arCOG02521@2157|Archaea,arCOG03504@2157|Archaea	2157|Archaea	P	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_28,NosD,Pectate_lyase_3
k141_2401_1	997884.HMPREF1068_00424	2.39e-50	181.0	COG1472@1|root,COG1472@2|Bacteria,4NE90@976|Bacteroidetes,2FMCU@200643|Bacteroidia,4AMW7@815|Bacteroidaceae	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 3 family	bglB	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
k141_2402_1	1094980.Mpsy_0945	1.53e-69	224.0	COG0334@1|root,arCOG01352@2157|Archaea,2XU0F@28890|Euryarchaeota,2N92V@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.2,1.4.1.3,1.4.1.4	ko:K00260,ko:K00261,ko:K00262	ko00220,ko00250,ko00430,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00430,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
k141_1217_1	1472716.KBK24_0120615	4.19e-60	205.0	COG3501@1|root,COG3501@2|Bacteria,1MU7Q@1224|Proteobacteria,2VJDF@28216|Betaproteobacteria,1K160@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Rhs element Vgr	-	-	-	ko:K11904	ko03070,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	Phage_GPD
k141_782_1	1121472.AQWN01000007_gene1134	8.13e-05	49.7	COG0500@1|root,COG2226@2|Bacteria,1UY28@1239|Firmicutes,24GXH@186801|Clostridia,262Q6@186807|Peptococcaceae	186801|Clostridia	Q	Nodulation protein S (NodS)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
k141_953_1	1459636.NTE_00892	8.1e-34	130.0	COG0531@1|root,arCOG00009@2157|Archaea,41SXX@651137|Thaumarchaeota	651137|Thaumarchaeota	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
k141_693_1	933262.AXAM01000014_gene268	1.12e-22	94.7	COG1032@1|root,COG1032@2|Bacteria,1MYYB@1224|Proteobacteria,42N3I@68525|delta/epsilon subdivisions,2WIPK@28221|Deltaproteobacteria,2MJDH@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
k141_506_1	33035.JPJF01000051_gene769	1.09e-12	72.8	COG5598@1|root,COG5598@2|Bacteria,1UY21@1239|Firmicutes,248BQ@186801|Clostridia	186801|Clostridia	H	PFAM Trimethylamine methyltransferase (MTTB)	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
k141_1949_1	864702.OsccyDRAFT_0687	7.96e-40	139.0	2CWXD@1|root,32T0J@2|Bacteria,1GAQJ@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_1318_1	1232437.KL661966_gene3140	1.75e-84	273.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,42M9S@68525|delta/epsilon subdivisions,2WJSZ@28221|Deltaproteobacteria,2MHW3@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k141_1851_1	658088.HMPREF0987_01830	0.000155	45.1	COG1396@1|root,COG1396@2|Bacteria,1UZN9@1239|Firmicutes,24APP@186801|Clostridia,27JH9@186928|unclassified Lachnospiraceae	186801|Clostridia	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
k141_2127_1	247490.KSU1_B0100	1.93e-85	264.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4372
k141_1766_1	236097.ADG881_2139	5.32e-17	83.6	COG1028@1|root,COG1028@2|Bacteria,1QTUD@1224|Proteobacteria,1T1HG@1236|Gammaproteobacteria,1XKI2@135619|Oceanospirillales	135619|Oceanospirillales	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k141_783_1	96561.Dole_1856	2.14e-85	275.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,2MIDR@213118|Desulfobacterales	28221|Deltaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon-3	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k141_1584_1	1128421.JAGA01000003_gene2857	2.45e-99	313.0	COG1132@1|root,COG1132@2|Bacteria	2|Bacteria	V	(ABC) transporter	yknV	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k141_417_1	159749.K0TQC7	3.23e-37	144.0	COG2801@1|root,KOG0017@2759|Eukaryota,2XF4I@2836|Bacillariophyta	159749.K0TQC7|-	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_509_1	1423775.BAMN01000003_gene1825	3.77e-22	98.2	COG1052@1|root,COG1052@2|Bacteria,1TSZ6@1239|Firmicutes,4HCIS@91061|Bacilli,3F4US@33958|Lactobacillaceae	91061|Bacilli	CH	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	ldhD	-	1.1.1.28	ko:K03778	ko00620,ko01120,map00620,map01120	-	R00704	RC00044	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k141_786_2	309801.trd_0638	1.77e-39	144.0	COG0040@1|root,COG0040@2|Bacteria,2G6DD@200795|Chloroflexi,27Y4I@189775|Thermomicrobia	189775|Thermomicrobia	E	ATP phosphoribosyltransferase	hisG	-	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
k141_1585_1	944565.HMPREF9127_0248	2.01e-07	58.2	COG0270@1|root,COG0863@1|root,COG1092@1|root,COG0270@2|Bacteria,COG0863@2|Bacteria,COG1092@2|Bacteria,1TSNX@1239|Firmicutes,2490C@186801|Clostridia,22IR3@1570339|Peptoniphilaceae	186801|Clostridia	L	C-5 cytosine-specific DNA methylase	-	-	2.1.1.37	ko:K00558	ko00270,ko01100,ko05206,map00270,map01100,map05206	M00035	R04858	RC00003,RC00332	ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_methylase
k141_1682_1	679190.HMPREF0650_0947	7.55e-18	86.3	COG3039@1|root,COG3039@2|Bacteria,4NJTB@976|Bacteroidetes,2FQ6H@200643|Bacteroidia	976|Bacteroidetes	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
k141_958_1	1453505.JASY01000001_gene3264	1.05e-10	67.8	COG4251@1|root,COG4251@2|Bacteria,4PM7A@976|Bacteroidetes,1IJK9@117743|Flavobacteriia,2P0PF@237|Flavobacterium	976|Bacteroidetes	T	Heme NO binding associated	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HNOBA,HisKA,PAS_3,PAS_9,Response_reg
k141_1951_1	247490.KSU1_B0100	3.03e-104	313.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4372
k141_695_1	455436.DS989811_gene1750	2.15e-47	172.0	COG3408@1|root,COG3408@2|Bacteria,1NJCP@1224|Proteobacteria,1RXM5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Bacterial alpha-L-rhamnosidase C-terminal domain	-	-	3.2.1.40	ko:K05989	-	-	-	-	ko00000,ko01000	-	-	-	Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N
k141_880_1	272562.CA_C3055	8.73e-32	124.0	COG2605@1|root,COG2605@2|Bacteria,1V0XM@1239|Firmicutes,25D2P@186801|Clostridia,36U63@31979|Clostridiaceae	186801|Clostridia	S	GHMP kinases C terminal	-	-	2.7.1.168	ko:K07031	ko00540,map00540	-	R09770	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
k141_2316_1	309798.COPRO5265_1513	1.94e-22	94.7	COG1013@1|root,COG1013@2|Bacteria,1TQJ2@1239|Firmicutes,25CAJ@186801|Clostridia,42FZW@68295|Thermoanaerobacterales	186801|Clostridia	C	TIGRFAM 2-oxoacid acceptor oxidoreductase, beta subunit, pyruvate 2-ketoisovalerate	korB	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
k141_2316_2	511051.CSE_01850	2.35e-34	131.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria	2|Bacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	porA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iLJ478.TM1164	PFOR_II,POR,POR_N,Transketolase_C
k141_2569_1	497965.Cyan7822_2659	7.58e-51	182.0	COG2203@1|root,COG3829@1|root,COG4251@1|root,COG2203@2|Bacteria,COG3829@2|Bacteria,COG4251@2|Bacteria,1G1Z5@1117|Cyanobacteria,3KH7P@43988|Cyanothece	1117|Cyanobacteria	T	Multi-sensor signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS_3,PAS_4
k141_788_1	7070.TC002946-PA	5.08e-09	62.8	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,41WI3@6656|Arthropoda,3SIRK@50557|Insecta	33208|Metazoa	O	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1,gag-asp_proteas,rve,zf-CCHC,zf-H2C2
k141_1407_1	747763.D7NW53_9CAUD	1.28e-23	100.0	4QBD3@10239|Viruses,4QXFU@35237|dsDNA viruses  no RNA stage,4QQ7Z@28883|Caudovirales,4QM04@10699|Siphoviridae	10699|Siphoviridae	S	viral capsid	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_1043_1	1237149.C900_02484	3.94e-74	232.0	COG3342@1|root,COG3342@2|Bacteria,4NITT@976|Bacteroidetes,47JYE@768503|Cytophagia	976|Bacteroidetes	S	Family of unknown function (DUF1028)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1028,TPR_16,TPR_19
k141_696_1	1122917.KB899661_gene1001	8.2e-46	162.0	COG3119@1|root,COG3119@2|Bacteria,1TQEP@1239|Firmicutes,4HIHE@91061|Bacilli,26R8R@186822|Paenibacillaceae	91061|Bacilli	P	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
k141_610_1	96561.Dole_0123	5.51e-06	49.3	COG2221@1|root,COG2221@2|Bacteria	2|Bacteria	C	Nitrite and sulphite reductase 4Fe-4S	frx-2	-	-	-	-	-	-	-	-	-	-	iAF987.Gmet_1033	Fer4
k141_2511_1	706587.Desti_2138	4.84e-17	86.7	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,42RU7@68525|delta/epsilon subdivisions,2WNTU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Belongs to the thiolase family	-	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k141_1606_1	1307761.L21SP2_1938	2.66e-35	137.0	COG3039@1|root,COG3039@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k141_961_1	314345.SPV1_13177	3.77e-22	95.1	COG0668@1|root,COG0668@2|Bacteria,1MXD2@1224|Proteobacteria	1224|Proteobacteria	M	mechanosensitive ion channel	ynaI	-	-	ko:K22044	-	-	-	-	ko00000,ko02000	1.A.23.3	-	-	MS_channel
k141_1522_1	933262.AXAM01000004_gene2374	3.47e-105	314.0	COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,42MW8@68525|delta/epsilon subdivisions,2WKI6@28221|Deltaproteobacteria,2MIK1@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus	phaC	-	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
k141_1522_2	933262.AXAM01000004_gene2373	1.15e-39	142.0	28KIX@1|root,2ZA44@2|Bacteria,1Q0JI@1224|Proteobacteria,42SSY@68525|delta/epsilon subdivisions,2WPVQ@28221|Deltaproteobacteria,2MK98@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E)	-	-	-	-	-	-	-	-	-	-	-	-	PHA_synth_III_E
k141_153_1	767817.Desgi_2163	2.27e-22	101.0	COG1148@1|root,COG1249@1|root,COG1148@2|Bacteria,COG1249@2|Bacteria,1V5YJ@1239|Firmicutes,248CC@186801|Clostridia	186801|Clostridia	C	binding domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Pyr_redox_2
k141_325_1	579137.Metvu_1319	5.97e-21	97.4	COG1042@1|root,arCOG01340@2157|Archaea,2XT9G@28890|Euryarchaeota,23QKV@183939|Methanococci	183939|Methanococci	C	PFAM CoA-binding domain protein	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
k141_1408_1	67593.Physo137253	1.02e-145	459.0	COG2801@1|root,2RRWG@2759|Eukaryota,3QH6N@4776|Peronosporales	4776|Peronosporales	L	transposition	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_1953_1	158190.SpiGrapes_0563	1.82e-19	94.0	COG1486@1|root,COG1486@2|Bacteria,2J688@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Glycoside hydrolase, family 4	-	-	3.2.1.22	ko:K07406	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_4,Glyco_hydro_4C
k141_225_1	868131.MSWAN_2316	8.72e-14	78.2	COG1599@1|root,arCOG01510@2157|Archaea,2XTJP@28890|Euryarchaeota,23NX4@183925|Methanobacteria	183925|Methanobacteria	L	Replication factor-A C terminal domain	-	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	CDC24_OB3,Rep_fac-A_C,tRNA_anti-codon
k141_2045_2	1348635.BBJY01000042_gene27	5.39e-33	115.0	arCOG05874@1|root,2ZJ01@2|Bacteria,1N8VY@1224|Proteobacteria,1SHGZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_1322_1	572546.Arcpr_0239	4.51e-24	96.3	COG2238@1|root,arCOG01344@2157|Archaea,2XXA6@28890|Euryarchaeota,24658@183980|Archaeoglobi	183980|Archaeoglobi	J	May be involved in maturation of the 30S ribosomal subunit	rps19e	-	-	ko:K02966	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19e
k141_2318_1	1230460.C495_03937	4.91e-11	65.5	COG1522@1|root,arCOG01585@2157|Archaea,2XW1H@28890|Euryarchaeota,23VJ7@183963|Halobacteria	183963|Halobacteria	K	COG1522 Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	Arc_trans_TRASH,HTH_24,HTH_AsnC-type
k141_1147_1	373903.Hore_13580	7.22e-24	102.0	COG1032@1|root,COG1032@2|Bacteria,1TPGT@1239|Firmicutes,247JS@186801|Clostridia,3WC51@53433|Halanaerobiales	186801|Clostridia	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4080,Radical_SAM
k141_1147_2	1408473.JHXO01000008_gene2655	9.75e-15	72.4	COG0330@1|root,COG0330@2|Bacteria,4NH8V@976|Bacteroidetes,2FQPC@200643|Bacteroidia	976|Bacteroidetes	O	SPFH Band 7 PHB domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
k141_326_1	742817.HMPREF9449_00795	9.8e-17	80.9	COG0438@1|root,COG0438@2|Bacteria,4PMXT@976|Bacteroidetes,2G0JY@200643|Bacteroidia,231CH@171551|Porphyromonadaceae	976|Bacteroidetes	M	Sulfotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
k141_326_2	1220534.B655_1765	5.39e-36	135.0	COG1600@1|root,arCOG02740@2157|Archaea,2Y6D7@28890|Euryarchaeota,23PPG@183925|Methanobacteria	183925|Methanobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
k141_1409_1	629773.AORY01000004_gene670	1.02e-05	53.9	COG4983@1|root,COG4983@2|Bacteria,1R17Z@1224|Proteobacteria,2TYY5@28211|Alphaproteobacteria,2K6TU@204457|Sphingomonadales	204457|Sphingomonadales	T	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_1772_1	96561.Dole_1204	7.98e-70	230.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2WUG9@28221|Deltaproteobacteria,2MMW2@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
k141_2048_2	1123242.JH636434_gene3874	3.01e-14	73.2	COG0305@1|root,COG0305@2|Bacteria,2IXJT@203682|Planctomycetes	203682|Planctomycetes	L	Participates in initiation and elongation during chromosome replication	-	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
k141_963_1	638303.Thal_1471	4.31e-35	132.0	COG1260@1|root,COG1260@2|Bacteria,2G3U0@200783|Aquificae	200783|Aquificae	I	Myo-inositol-1-phosphate synthase	-	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth
k141_963_2	1122138.AQUZ01000005_gene2482	0.000618	43.5	COG0189@1|root,COG0189@2|Bacteria,2HXBM@201174|Actinobacteria,4DPA1@85009|Propionibacteriales	2|Bacteria	HJ	RimK-like ATP-grasp domain	-	-	6.3.5.5	ko:K01955,ko:K05844	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000,ko03009	-	-	-	ATP-grasp_3,RimK
k141_1688_1	1121335.Clst_0621	4.29e-90	278.0	COG4806@1|root,COG4806@2|Bacteria,1TS42@1239|Firmicutes,2487G@186801|Clostridia,3WN5C@541000|Ruminococcaceae	186801|Clostridia	G	Belongs to the rhamnose isomerase family	rhaA	-	5.3.1.14	ko:K01813	ko00051,ko01120,map00051,map01120	-	R02437	RC00434	ko00000,ko00001,ko01000	-	-	-	RhaA
k141_597_1	573063.Metin_0497	3.57e-43	149.0	COG2048@1|root,arCOG00964@2157|Archaea,2XXYP@28890|Euryarchaeota,23Q0K@183939|Methanococci	183939|Methanococci	C	heterodisulfide reductase	hdrC1	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_17,Fer4_8,Fer4_9
k141_597_2	243232.MJ_0743	3.04e-52	174.0	COG2048@1|root,arCOG00338@2157|Archaea,2XTWJ@28890|Euryarchaeota,23Q7G@183939|Methanococci	183939|Methanococci	C	heterodisulfide reductase	hdrB1	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
k141_1857_1	1261545.MBE-HAL_0775	3.7e-40	152.0	COG1202@1|root,arCOG00554@2157|Archaea,2XUCK@28890|Euryarchaeota,23SJE@183963|Halobacteria	183963|Halobacteria	L	DEAD DEAH box helicase	ashA	-	-	ko:K03725	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,Helicase_C
k141_1588_1	1541960.KQ78_01311	5.67e-10	63.5	COG1145@1|root,COG1145@2|Bacteria	2|Bacteria	C	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_6,Fer4_7
k141_2572_1	335543.Sfum_2942	1.07e-21	92.4	COG2358@1|root,COG2358@2|Bacteria,1PK4K@1224|Proteobacteria,42X0K@68525|delta/epsilon subdivisions,2WT1F@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	TRAP transporter solute receptor, TAXI family	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
k141_2572_2	335543.Sfum_2943	1.07e-34	133.0	COG0784@1|root,COG2202@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg,dCache_1
k141_1524_1	536232.CLM_3609	1.65e-52	177.0	COG2025@1|root,COG2025@2|Bacteria,1TPC8@1239|Firmicutes,247NF@186801|Clostridia,36DD9@31979|Clostridiaceae	186801|Clostridia	C	Electron transfer flavoprotein	etfA	-	1.3.1.108	ko:K03522,ko:K22432	-	-	-	-	ko00000,ko01000,ko04147	-	-	-	ETF,ETF_alpha
k141_2667_1	81824.XP_001749481.1	5.63e-22	100.0	COG1012@1|root,COG1250@1|root,KOG2304@2759|Eukaryota,KOG2450@2759|Eukaryota,38CDB@33154|Opisthokonta	33154|Opisthokonta	C	aldehyde dehydrogenase (NAD) activity	ALDH9A1	GO:0000166,GO:0001505,GO:0001655,GO:0001822,GO:0001889,GO:0003674,GO:0003824,GO:0004028,GO:0004029,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006575,GO:0006577,GO:0006578,GO:0006807,GO:0007275,GO:0008150,GO:0008152,GO:0009058,GO:0009437,GO:0009987,GO:0010817,GO:0016491,GO:0016620,GO:0016903,GO:0019145,GO:0032501,GO:0032502,GO:0034641,GO:0036094,GO:0042133,GO:0042136,GO:0042398,GO:0042445,GO:0042802,GO:0042803,GO:0043176,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045329,GO:0046983,GO:0047105,GO:0048037,GO:0048513,GO:0048731,GO:0048732,GO:0048856,GO:0050662,GO:0051287,GO:0055114,GO:0061008,GO:0065007,GO:0065008,GO:0071704,GO:0072001,GO:0097159,GO:0097164,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576	1.1.1.35,1.2.1.3,1.2.1.47	ko:K00022,ko:K00149	ko00010,ko00053,ko00062,ko00071,ko00280,ko00281,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00650,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00010,map00053,map00062,map00071,map00280,map00281,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00650,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00085,M00087,M00135	R00631,R00710,R00904,R01752,R01778,R01975,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04203,R04506,R04737,R04739,R04741,R04743,R04745,R04748,R04903,R05050,R05066,R06941,R08094	RC00029,RC00047,RC00071,RC00080,RC00099,RC00103,RC00117,RC00186,RC00241,RC00242,RC00525,RC00816	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k141_1955_1	397948.Cmaq_0172	2.07e-75	253.0	COG4354@1|root,arCOG03865@2157|Archaea	2157|Archaea	G	intracellular protein transport	-	-	3.2.1.40	ko:K05989	-	-	-	-	ko00000,ko01000	-	-	-	Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N
k141_1151_1	1510531.JQJJ01000008_gene4010	7.08e-30	120.0	COG0381@1|root,COG0381@2|Bacteria,1MWZN@1224|Proteobacteria,2TTGZ@28211|Alphaproteobacteria,3JTYU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	UDP-N-acetylglucosamine 2-epimerase	wecB	-	5.1.3.14	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase_2
k141_964_1	237368.SCABRO_02792	1.05e-154	449.0	COG3344@1|root,COG3344@2|Bacteria,2J0GH@203682|Planctomycetes	203682|Planctomycetes	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k141_966_1	324602.Caur_2083	8.68e-30	122.0	COG2211@1|root,COG2211@2|Bacteria,2G6RZ@200795|Chloroflexi,3764D@32061|Chloroflexia	32061|Chloroflexia	G	MFS/sugar transport protein	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
k141_2050_1	717605.Theco_2552	1.09e-19	89.7	COG3344@1|root,COG3344@2|Bacteria,1TP9A@1239|Firmicutes,4HEIB@91061|Bacilli,26RJ8@186822|Paenibacillaceae	91061|Bacilli	L	DNA polymerase	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k141_2320_1	436308.Nmar_1223	1.56e-06	55.1	COG0464@1|root,arCOG01308@2157|Archaea,41S7X@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Cell division protein 48 (CDC48) domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N
k141_226_1	298386.PBPRB1391	8.34e-48	168.0	COG3677@1|root,COG3677@2|Bacteria,1R3ZS@1224|Proteobacteria,1SZQS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	ISXO2-like transposase domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1595,Zn_Tnp_IS1595
k141_2576_1	1047013.AQSP01000144_gene916	1.52e-70	225.0	COG1104@1|root,COG1104@2|Bacteria,2NNVR@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
k141_2216_1	387631.Asulf_00546	1.84e-44	156.0	COG2998@1|root,arCOG00229@2157|Archaea,2XUR9@28890|Euryarchaeota,246XU@183980|Archaeoglobi	183980|Archaeoglobi	P	PBP superfamily domain	-	-	-	ko:K05772	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	PBP_like_2
k141_1548_1	936455.KI421499_gene740	3.25e-50	171.0	COG1028@1|root,COG1028@2|Bacteria,1MXNQ@1224|Proteobacteria,2TUHP@28211|Alphaproteobacteria,3JX3S@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k141_201_1	391623.TERMP_01356	5.12e-54	192.0	COG0068@1|root,arCOG01187@2157|Archaea,2XTHZ@28890|Euryarchaeota,242XT@183968|Thermococci	183968|Thermococci	O	Belongs to the carbamoyltransferase HypF family	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Peptidase_M22,Sua5_yciO_yrdC,zf-HYPF
k141_1013_4	1227500.C494_07640	3.32e-05	46.6	COG1948@1|root,arCOG04206@2157|Archaea	2157|Archaea	L	ERCC4 domain protein	-	-	-	ko:K03703,ko:K10848	ko03420,ko03460,map03420,map03460	-	-	-	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	ERCC4,HHH_2,HHH_5
k141_1194_1	570268.ANBB01000124_gene3999	1.88e-16	83.2	COG2826@1|root,COG2826@2|Bacteria,2GMZX@201174|Actinobacteria	201174|Actinobacteria	L	Transposase and inactivated derivatives IS30 family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_38,rve
k141_2014_1	1123226.KB899285_gene3894	1.07e-43	159.0	COG0657@1|root,COG0657@2|Bacteria,1UYX6@1239|Firmicutes,4HEMG@91061|Bacilli	91061|Bacilli	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
k141_1476_1	717606.PaecuDRAFT_3058	9.74e-10	63.2	COG0477@1|root,COG0477@2|Bacteria,1TPHW@1239|Firmicutes,4H9YA@91061|Bacilli,26RTR@186822|Paenibacillaceae	91061|Bacilli	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k141_474_1	159749.K0RZE7	1.67e-14	69.3	2D0S2@1|root,2SF6P@2759|Eukaryota	2759|Eukaryota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_1778_3	498211.CJA_1821	2.89e-23	95.5	COG4422@1|root,COG4422@2|Bacteria,1MXQI@1224|Proteobacteria,1RSNF@1236|Gammaproteobacteria,1FI54@10|Cellvibrio	1236|Gammaproteobacteria	S	Pfam:Gp37_Gp68	-	-	-	-	-	-	-	-	-	-	-	-	DUF5131
k141_1963_1	263820.PTO0587	7.18e-15	75.9	COG0470@1|root,arCOG00469@2157|Archaea,2XTC8@28890|Euryarchaeota,241K8@183967|Thermoplasmata	183967|Thermoplasmata	L	Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA	rfcS	-	-	ko:K04801	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA,Rep_fac_C
k141_1963_2	877455.Metbo_1952	2.07e-16	82.8	COG0101@1|root,arCOG04449@2157|Archaea,2XTH5@28890|Euryarchaeota,23NZW@183925|Methanobacteria	183925|Methanobacteria	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
k141_891_1	1400520.LFAB_14805	4.18e-27	114.0	COG1233@1|root,COG1233@2|Bacteria,1UU71@1239|Firmicutes,4HA25@91061|Bacilli,3F9H5@33958|Lactobacillaceae	91061|Bacilli	Q	HI0933-like protein	-	-	5.2.1.13	ko:K09835	ko00906,ko01100,ko01110,map00906,map01100,map01110	M00097	R07512	RC01960	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
k141_2084_1	439235.Dalk_5066	2.97e-67	222.0	COG0247@1|root,COG1150@1|root,COG2181@1|root,COG0247@2|Bacteria,COG1150@2|Bacteria,COG2181@2|Bacteria,1R44N@1224|Proteobacteria,42NTE@68525|delta/epsilon subdivisions,2WJN8@28221|Deltaproteobacteria,2MJEV@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Nitrate reductase gamma subunit	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_17,Fer4_8,Nitrate_red_gam
k141_914_2	1137799.GZ78_14485	3.01e-113	334.0	COG2801@1|root,COG2801@2|Bacteria,1MVC8@1224|Proteobacteria,1RXYF@1236|Gammaproteobacteria,1XHWD@135619|Oceanospirillales	135619|Oceanospirillales	L	HTH-like domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
k141_914_3	43989.cce_5192	3.71e-26	100.0	COG2963@1|root,COG2963@2|Bacteria,1GAAT@1117|Cyanobacteria	1117|Cyanobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
k141_1727_1	224325.AF_0595	5.29e-22	100.0	COG2244@1|root,arCOG02209@2157|Archaea,2XZTW@28890|Euryarchaeota,246RI@183980|Archaeoglobi	183980|Archaeoglobi	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_C
k141_830_1	1286171.EAL2_c01150	1.1e-22	103.0	COG0209@1|root,COG0209@2|Bacteria,1TT3U@1239|Firmicutes,24C4U@186801|Clostridia	186801|Clostridia	F	TIGRFAM ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	ATP-cone,Ribonuc_red_lgC
k141_2452_1	765913.ThidrDRAFT_4063	1.29e-06	54.7	COG1239@1|root,COG1240@1|root,COG1239@2|Bacteria,COG1240@2|Bacteria,1MYHV@1224|Proteobacteria,1RS9F@1236|Gammaproteobacteria,1WXBD@135613|Chromatiales	135613|Chromatiales	H	introduces a magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX	bchD	-	6.6.1.1	ko:K03404	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	-	VWA_2
k141_1002_1	1173026.Glo7428_2747	2.56e-18	92.8	COG0642@1|root,COG0784@1|root,COG2203@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1G3C4@1117|Cyanobacteria	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,PAS_4,PAS_8,PAS_9,Response_reg
k141_2811_1	861360.AARI_35780	8.17e-13	74.3	COG3677@1|root,COG3677@2|Bacteria,2IEJD@201174|Actinobacteria,1WAKS@1268|Micrococcaceae	201174|Actinobacteria	L	4.5 Transposon and IS	tnp3503b	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k141_1907_1	555088.DealDRAFT_2538	8.4e-75	241.0	COG1960@1|root,COG1960@2|Bacteria,1V03D@1239|Firmicutes,24A8N@186801|Clostridia	186801|Clostridia	C	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M
k141_1810_2	483219.LILAB_32215	1.61e-47	154.0	COG3436@1|root,COG3436@2|Bacteria,1N638@1224|Proteobacteria,430NK@68525|delta/epsilon subdivisions,2WVZ0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM IS66 Orf2 family protein	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	TnpB_IS66
k141_558_1	1220534.B655_2422	3.47e-48	167.0	COG1149@1|root,arCOG04073@2157|Archaea,2XWS4@28890|Euryarchaeota	28890|Euryarchaeota	D	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CbiA,Fer4,Fer4_21
k141_2001_1	1121271.AUCM01000041_gene423	9.56e-53	176.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2TU72@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21
k141_915_2	46234.ANA_C13142	3.97e-147	430.0	COG3385@1|root,COG3385@2|Bacteria,1G2T1@1117|Cyanobacteria,1HMX0@1161|Nostocales	1117|Cyanobacteria	L	PFAM Transposase DDE domain	-	-	-	ko:K07495	-	-	-	-	ko00000	-	-	-	DDE_5,DDE_Tnp_1
k141_2085_1	502558.EGYY_28870	4.87e-75	250.0	COG0542@1|root,COG0542@2|Bacteria,2GJ73@201174|Actinobacteria,4CV0R@84998|Coriobacteriia	84998|Coriobacteriia	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k141_2453_1	926569.ANT_16670	2.71e-59	195.0	COG0665@1|root,COG0665@2|Bacteria,2G6HT@200795|Chloroflexi	200795|Chloroflexi	E	FAD dependent oxidoreductase	-	-	1.5.3.1	ko:K00303	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO
k141_2453_2	1047013.AQSP01000126_gene2731	6.65e-31	121.0	COG0446@1|root,COG1142@1|root,COG1251@1|root,COG2080@1|root,COG0446@2|Bacteria,COG1142@2|Bacteria,COG1251@2|Bacteria,COG2080@2|Bacteria,2NP2E@2323|unclassified Bacteria	2|Bacteria	C	FAD dependent oxidoreductase	-	-	1.12.5.1,1.2.5.3,1.3.99.16,1.7.1.15	ko:K00205,ko:K00362,ko:K02573,ko:K03518,ko:K05927,ko:K07302	ko00680,ko00910,ko01100,ko01120,ko01200,map00680,map00910,map01100,map01120,map01200	M00530,M00567	R00787,R03015,R08060,R11168,R11743	RC00176,RC00197,RC00323,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2,Fer2_2,Fer2_4,Fer2_BFD,Fer4,Fer4_20,Fer4_7,GXGXG,NiFe_hyd_SSU_C,Oxidored_q6,Pyr_redox_2
k141_1372_1	706191.PANA_4020	1.82e-40	153.0	COG3387@1|root,COG3387@2|Bacteria,1MYVI@1224|Proteobacteria,1RRIJ@1236|Gammaproteobacteria,3W1RC@53335|Pantoea	1236|Gammaproteobacteria	G	to Agrobacterium tumefaciens str. C58, glucoamylase (NCBI NP_355831.2)	cga	-	3.2.1.3	ko:K01178	ko00500,ko01100,map00500,map01100	-	R01790,R01791,R06199	-	ko00000,ko00001,ko01000	-	GH15	-	Glucodextran_N,Glyco_hydro_15
k141_1909_3	374847.Kcr_1569	6.12e-06	47.4	COG0256@1|root,arCOG04088@2157|Archaea	2157|Archaea	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rpl18	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18_c,Ribosomal_L5e
k141_1374_1	399550.Smar_1238	6.59e-24	102.0	COG0462@1|root,arCOG00067@2157|Archaea,2XQE3@28889|Crenarchaeota	28889|Crenarchaeota	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran,Pribosyltran_N
k141_2274_1	1184251.TCELL_0286	1.12e-62	214.0	COG0459@1|root,arCOG01257@2157|Archaea,2XPYR@28889|Crenarchaeota	28889|Crenarchaeota	O	PFAM chaperonin Cpn60 TCP-1	thsB	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0042802,GO:0044183,GO:0051082,GO:0061077	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
k141_653_1	933262.AXAM01000001_gene421	2.16e-54	175.0	COG3599@1|root,COG3599@2|Bacteria,1NCAV@1224|Proteobacteria,42VH6@68525|delta/epsilon subdivisions,2WS27@28221|Deltaproteobacteria,2MJQX@213118|Desulfobacterales	28221|Deltaproteobacteria	D	DivIVA protein	-	-	-	ko:K04074	-	-	-	-	ko00000,ko03036	-	-	-	DivIVA
k141_833_1	1231391.AMZF01000014_gene2320	1.1e-47	175.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,2VHQ3@28216|Betaproteobacteria,3T26K@506|Alcaligenaceae	28216|Betaproteobacteria	H	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k141_1466_1	1121405.dsmv_0131	2.54e-16	78.2	COG0107@1|root,COG0118@1|root,COG0107@2|Bacteria,COG0118@2|Bacteria,1MUS0@1224|Proteobacteria,42M44@68525|delta/epsilon subdivisions,2WJFW@28221|Deltaproteobacteria,2MIFH@213118|Desulfobacterales	28221|Deltaproteobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	-	-	ko:K01663,ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase,His_biosynth
k141_1633_1	7668.SPU_005630-tr	3.26e-119	396.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39TZY@33154|Opisthokonta,3BI15@33208|Metazoa,3CYKV@33213|Bilateria	33208|Metazoa	J	protein phosphatase regulator activity	-	-	2.3.1.15,2.4.2.29	ko:K13506,ko:K15407	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R03789,R09380,R10209	RC00004,RC00039,RC00041,RC00063	ko00000,ko00001,ko00002,ko01000,ko01004,ko03016	-	-	-	Exo_endo_phos_2,RVT_1
k141_916_3	1468411.X2KTW9_9CAUD	7.27e-11	63.2	4QH10@10239|Viruses,4QVVN@35237|dsDNA viruses  no RNA stage,4QSY9@28883|Caudovirales,4QMA5@10699|Siphoviridae	10699|Siphoviridae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_735_1	27923.ML13539a-PA	1.3e-60	220.0	COG2801@1|root,KOG0017@2759|Eukaryota,38DPC@33154|Opisthokonta,3BS5J@33208|Metazoa	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_2,rve
k141_1540_2	76869.PputGB1_1755	3.54e-07	54.7	28I8X@1|root,2Z8BQ@2|Bacteria,1MW9X@1224|Proteobacteria,1RR0M@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_1540_3	278957.ABEA03000173_gene2411	3.34e-08	61.6	28I8X@1|root,2Z8BQ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_393_1	7222.FBpp0147214	3.57e-12	70.1	COG0709@1|root,KOG3939@2759|Eukaryota,38DV8@33154|Opisthokonta,3BA8C@33208|Metazoa,3CU7W@33213|Bilateria,41VBE@6656|Arthropoda,3SQMN@50557|Insecta,4522J@7147|Diptera,45X7G@7214|Drosophilidae	33208|Metazoa	T	ATP- binding	-	GO:0000166,GO:0003674,GO:0003824,GO:0004756,GO:0005488,GO:0005524,GO:0006082,GO:0006520,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016259,GO:0016260,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016781,GO:0017076,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C
k141_30_1	1121346.KB899825_gene2997	8.41e-19	88.6	COG0647@1|root,COG0647@2|Bacteria,1TQGM@1239|Firmicutes,4HA3R@91061|Bacilli,26TV6@186822|Paenibacillaceae	91061|Bacilli	G	Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro	nagD	-	3.1.3.41	ko:K01101	ko00627,ko01120,map00627,map01120	-	R03024	RC00151	ko00000,ko00001,ko01000	-	-	-	Hydrolase_6,Hydrolase_like
k141_1481_1	1047013.AQSP01000122_gene2249	1.72e-134	399.0	28NDD@1|root,2ZBG6@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k141_481_1	65071.PYU1_T010888	6.48e-24	99.4	KOG4252@1|root,KOG4252@2759|Eukaryota,1MDNN@121069|Pythiales	121069|Pythiales	T	Ras of Complex, Roc, domain of DAPkinase	-	-	-	-	-	-	-	-	-	-	-	-	Ras
k141_747_1	445971.ANASTE_01243	1.33e-14	77.4	COG0546@1|root,COG0546@2|Bacteria,1V1FQ@1239|Firmicutes,24G1U@186801|Clostridia,25WHJ@186806|Eubacteriaceae	186801|Clostridia	S	Psort location Cytoplasmic, score 8.87	nt5e	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
k141_665_2	298653.Franean1_7332	5.73e-18	89.4	COG1475@1|root,COG1475@2|Bacteria,2GNRN@201174|Actinobacteria,4ERK5@85013|Frankiales	201174|Actinobacteria	K	Belongs to the ParB family	parB	GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005694,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044464,GO:0060187,GO:0071944	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
k141_1482_1	1042376.AFPK01000043_gene990	1.67e-20	94.7	COG4152@1|root,COG4152@2|Bacteria,4NEJE@976|Bacteroidetes,1HXY0@117743|Flavobacteriia,406VX@61432|unclassified Flavobacteriaceae	976|Bacteroidetes	S	Domain of unknown function (DUF4162)	natA	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
k141_1558_1	981336.F944_01744	2.79e-33	133.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria,3NMBB@468|Moraxellaceae	1236|Gammaproteobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k141_1741_1	1121344.JHZO01000007_gene2035	2.17e-24	100.0	COG1014@1|root,COG1014@2|Bacteria,1V1DT@1239|Firmicutes,24HIC@186801|Clostridia,3WHSE@541000|Ruminococcaceae	186801|Clostridia	C	Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases gamma subunit	iorB	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
k141_849_1	1343739.PAP_00020	7.93e-49	177.0	COG1372@1|root,COG1933@1|root,arCOG03145@2157|Archaea,arCOG04447@2157|Archaea,2XU5S@28890|Euryarchaeota,24309@183968|Thermococci	183968|Thermococci	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polC	GO:0003674,GO:0005488,GO:0005515,GO:0042802	2.7.7.7	ko:K02322	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	Intein_splicing,LAGLIDADG_3,PolC_DP2
k141_1387_1	247156.NFA_9290	1.81e-13	75.5	COG1028@1|root,COG1028@2|Bacteria,2I41V@201174|Actinobacteria,4G9NR@85025|Nocardiaceae	201174|Actinobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k141_1288_1	102232.GLO73106DRAFT_00020770	1.22e-29	117.0	COG0144@1|root,COG0144@2|Bacteria,1G4U9@1117|Cyanobacteria	1117|Cyanobacteria	J	Methyltransferase FkbM domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
k141_1388_2	349161.Dred_1768	2.91e-11	65.5	COG1884@1|root,COG1884@2|Bacteria,1TQAD@1239|Firmicutes,24BDK@186801|Clostridia	186801|Clostridia	I	PFAM Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
k141_2191_1	370438.PTH_0610	1.53e-74	248.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,260S3@186807|Peptococcaceae	186801|Clostridia	C	Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
k141_2637_1	445973.CLOBAR_01635	9.17e-22	99.4	COG1143@1|root,COG2006@1|root,COG1143@2|Bacteria,COG2006@2|Bacteria,1TRX2@1239|Firmicutes,249GX@186801|Clostridia,25SZJ@186804|Peptostreptococcaceae	186801|Clostridia	C	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,Fer4,Fer4_10,Fer4_7
k141_2547_1	192952.MM_1029	6.44e-09	62.4	COG1386@1|root,arCOG02613@2157|Archaea,2XZ7Q@28890|Euryarchaeota,2N9UX@224756|Methanomicrobia	224756|Methanomicrobia	K	Segregation and condensation complex subunit ScpB	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
k141_1823_3	1415775.U729_2598	4.7e-05	50.4	COG3728@1|root,COG3728@2|Bacteria,1VAD9@1239|Firmicutes,24NMP@186801|Clostridia,36JGF@31979|Clostridiaceae	186801|Clostridia	L	Terminase small subunit	-	-	-	ko:K07474	-	-	-	-	ko00000	-	-	-	Terminase_2
k141_1484_1	1121324.CLIT_2c00020	9.83e-33	135.0	COG4584@1|root,COG4584@2|Bacteria,1TR5X@1239|Firmicutes,25D02@186801|Clostridia	186801|Clostridia	L	integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,Mu-transpos_C,rve
k141_666_1	500640.CIT292_09490	9.36e-25	102.0	COG0634@1|root,COG0634@2|Bacteria,1NRT8@1224|Proteobacteria,1RNPQ@1236|Gammaproteobacteria,3WXGZ@544|Citrobacter	1236|Gammaproteobacteria	F	Phosphoribosyl transferase domain	hpt	GO:0000287,GO:0003674,GO:0003824,GO:0004422,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006166,GO:0006177,GO:0006188,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032261,GO:0032263,GO:0032264,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0043094,GO:0043101,GO:0043167,GO:0043169,GO:0043173,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046040,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
k141_2019_1	96561.Dole_1861	2.58e-83	256.0	COG3547@1|root,COG3547@2|Bacteria	2|Bacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k141_1922_1	324925.Ppha_2868	5.28e-24	102.0	COG1266@1|root,COG1266@2|Bacteria,1FFPR@1090|Chlorobi	1090|Chlorobi	S	PFAM Abortive infection protein	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
k141_749_1	439235.Dalk_1591	1.14e-47	162.0	COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,42R0M@68525|delta/epsilon subdivisions,2X5MH@28221|Deltaproteobacteria,2MJM7@213118|Desulfobacterales	28221|Deltaproteobacteria	NT	CheR methyltransferase, SAM binding domain	-	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR,CheR_N
k141_1648_1	1127692.HMPREF9075_01357	2.83e-52	173.0	COG5421@1|root,COG5421@2|Bacteria,4NIXE@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k141_2639_1	374847.Kcr_0864	5.99e-18	90.9	COG0006@1|root,arCOG01000@2157|Archaea	2157|Archaea	E	Belongs to the peptidase M24B family	pepQ1	-	3.4.11.9,3.4.13.9	ko:K01262,ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
k141_851_1	335543.Sfum_3954	1.66e-33	130.0	COG3259@1|root,COG3259@2|Bacteria,1QUQ7@1224|Proteobacteria,42N63@68525|delta/epsilon subdivisions,2WJPA@28221|Deltaproteobacteria,2MQRM@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM nickel-dependent hydrogenase, large subunit	-	-	1.12.1.2,1.8.98.5	ko:K00436,ko:K14126	ko00680,map00680	-	R00019,R00700,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
k141_125_1	1232437.KL662007_gene1684	2.72e-152	437.0	COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,42SSD@68525|delta/epsilon subdivisions,2WPWR@28221|Deltaproteobacteria,2MK6M@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Putative transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
k141_125_2	1232437.KL662007_gene1686	5.86e-31	115.0	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,42UXI@68525|delta/epsilon subdivisions,2WQST@28221|Deltaproteobacteria,2MKNI@213118|Desulfobacterales	28221|Deltaproteobacteria	L	DNA breaking-rejoining enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
k141_2193_1	338963.Pcar_0532	6.29e-45	156.0	COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,42NNQ@68525|delta/epsilon subdivisions,2WM2H@28221|Deltaproteobacteria,43TYM@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k141_1925_1	751944.HALDL1_10695	3.05e-17	84.3	COG0244@1|root,arCOG04288@2157|Archaea,2XU7C@28890|Euryarchaeota,23T1A@183963|Halobacteria	183963|Halobacteria	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rpl10	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
k141_396_1	67593.Physo137112	7.65e-21	94.7	COG1100@1|root,KOG0087@2759|Eukaryota,3QDTJ@4776|Peronosporales	4776|Peronosporales	U	Rab subfamily of small GTPases	-	-	-	-	-	-	-	-	-	-	-	-	Ras
k141_1140_1	1124780.ANNU01000010_gene3680	4.97e-09	58.9	COG3210@1|root,COG3291@1|root,COG3210@2|Bacteria,COG3291@2|Bacteria,4NPRK@976|Bacteroidetes	976|Bacteroidetes	U	PFAM Uncharacterised BCR, COG1649	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_1140_2	1220534.B655_0616	1.07e-26	103.0	COG0221@1|root,arCOG01711@2157|Archaea,2XTSU@28890|Euryarchaeota,23P2K@183925|Methanobacteria	183925|Methanobacteria	C	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions	-	-	3.6.1.1	ko:K01507	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyrophosphatase
k141_688_1	1038869.AXAN01000035_gene2140	3.1e-62	211.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2VNZQ@28216|Betaproteobacteria,1KGKU@119060|Burkholderiaceae	28216|Betaproteobacteria	P	E1-E2 ATPase	-	-	3.6.3.6	ko:K01535	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.3.3	-	-	Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k141_499_1	1123008.KB905712_gene770	4.37e-67	216.0	COG0675@1|root,COG0675@2|Bacteria,4PJXW@976|Bacteroidetes,2FTB4@200643|Bacteroidia	976|Bacteroidetes	L	Putative transposase DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_OrfB_IS605,OrfB_IS605,OrfB_Zn_ribbon
k141_1942_1	1268072.PSAB_15125	7.55e-37	138.0	COG1600@1|root,COG1600@2|Bacteria,1V18K@1239|Firmicutes,4I667@91061|Bacilli,26QR7@186822|Paenibacillaceae	91061|Bacilli	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	M1-685	-	-	-	-	-	-	-	-	-	-	-	-
k141_870_1	1167006.UWK_00988	2.9e-55	176.0	2BK9M@1|root,32EPT@2|Bacteria,1NC6I@1224|Proteobacteria,42XFJ@68525|delta/epsilon subdivisions,2WT5J@28221|Deltaproteobacteria,2MP6B@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_1512_1	1047013.AQSP01000138_gene1066	8.46e-128	385.0	COG0500@1|root,COG1181@1|root,COG1181@2|Bacteria,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N,Methyltransf_25
k141_1675_2	176946.XP_007438749.1	1.15e-15	79.7	KOG0739@1|root,KOG0739@2759|Eukaryota,38D1Q@33154|Opisthokonta,3BCY8@33208|Metazoa,3CU12@33213|Bilateria,47Z51@7711|Chordata,48V89@7742|Vertebrata	33208|Metazoa	O	Belongs to the AAA ATPase family	VPS4A	GO:0000070,GO:0000075,GO:0000166,GO:0000278,GO:0000280,GO:0000323,GO:0000819,GO:0000910,GO:0000916,GO:0000920,GO:0000922,GO:0001654,GO:0001745,GO:0001751,GO:0001754,GO:0003002,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005764,GO:0005768,GO:0005769,GO:0005770,GO:0005773,GO:0005774,GO:0005813,GO:0005815,GO:0005819,GO:0005829,GO:0005856,GO:0005886,GO:0006508,GO:0006511,GO:0006605,GO:0006622,GO:0006623,GO:0006807,GO:0006810,GO:0006869,GO:0006886,GO:0006900,GO:0006906,GO:0006914,GO:0006996,GO:0006997,GO:0006998,GO:0007010,GO:0007032,GO:0007034,GO:0007041,GO:0007049,GO:0007059,GO:0007080,GO:0007093,GO:0007163,GO:0007275,GO:0007346,GO:0007389,GO:0007399,GO:0007423,GO:0008022,GO:0008104,GO:0008144,GO:0008150,GO:0008152,GO:0008593,GO:0009056,GO:0009057,GO:0009653,GO:0009838,GO:0009887,GO:0009966,GO:0009967,GO:0009968,GO:0009987,GO:0010008,GO:0010256,GO:0010389,GO:0010564,GO:0010646,GO:0010647,GO:0010648,GO:0010876,GO:0010948,GO:0010972,GO:0012505,GO:0015031,GO:0015630,GO:0015833,GO:0015850,GO:0015918,GO:0016020,GO:0016032,GO:0016043,GO:0016050,GO:0016192,GO:0016197,GO:0016236,GO:0016322,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017016,GO:0017048,GO:0017076,GO:0017111,GO:0017157,GO:0019058,GO:0019068,GO:0019076,GO:0019538,GO:0019899,GO:0019904,GO:0019941,GO:0021700,GO:0022008,GO:0022402,GO:0022411,GO:0022607,GO:0023051,GO:0023056,GO:0023057,GO:0030029,GO:0030036,GO:0030154,GO:0030163,GO:0030182,GO:0030301,GO:0030496,GO:0030554,GO:0030865,GO:0030866,GO:0031032,GO:0031090,GO:0031267,GO:0031410,GO:0031468,GO:0031982,GO:0032365,GO:0032366,GO:0032367,GO:0032465,GO:0032466,GO:0032501,GO:0032502,GO:0032506,GO:0032553,GO:0032555,GO:0032559,GO:0032879,GO:0032880,GO:0032984,GO:0032991,GO:0033036,GO:0033365,GO:0034058,GO:0034613,GO:0035088,GO:0035639,GO:0035890,GO:0035891,GO:0036094,GO:0036213,GO:0036257,GO:0036258,GO:0036452,GO:0039702,GO:0040008,GO:0040011,GO:0040012,GO:0040017,GO:0042051,GO:0042058,GO:0042461,GO:0042462,GO:0042551,GO:0042623,GO:0042886,GO:0043162,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043624,GO:0043632,GO:0043900,GO:0043901,GO:0043902,GO:0043903,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044126,GO:0044130,GO:0044144,GO:0044146,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044403,GO:0044419,GO:0044422,GO:0044424,GO:0044425,GO:0044430,GO:0044433,GO:0044437,GO:0044440,GO:0044444,GO:0044446,GO:0044464,GO:0044837,GO:0044878,GO:0045184,GO:0045197,GO:0045463,GO:0045465,GO:0045470,GO:0045742,GO:0045746,GO:0045786,GO:0045921,GO:0045926,GO:0045930,GO:0046530,GO:0046755,GO:0046907,GO:0048284,GO:0048285,GO:0048468,GO:0048469,GO:0048471,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048524,GO:0048583,GO:0048584,GO:0048585,GO:0048592,GO:0048666,GO:0048699,GO:0048731,GO:0048749,GO:0048856,GO:0048869,GO:0050000,GO:0050789,GO:0050792,GO:0050794,GO:0051020,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051179,GO:0051234,GO:0051261,GO:0051276,GO:0051301,GO:0051302,GO:0051303,GO:0051310,GO:0051603,GO:0051640,GO:0051641,GO:0051649,GO:0051656,GO:0051701,GO:0051704,GO:0051726,GO:0051782,GO:0052126,GO:0052192,GO:0060341,GO:0060627,GO:0061024,GO:0061025,GO:0061245,GO:0061462,GO:0061640,GO:0061738,GO:0061919,GO:0065007,GO:0070727,GO:0070925,GO:0071695,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071944,GO:0072319,GO:0072594,GO:0072665,GO:0072666,GO:0090174,GO:0090543,GO:0090596,GO:0090611,GO:0097159,GO:0097352,GO:0097367,GO:0097708,GO:0098588,GO:0098796,GO:0098805,GO:0098813,GO:0140014,GO:1901184,GO:1901186,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901987,GO:1901988,GO:1901990,GO:1901991,GO:1902186,GO:1902188,GO:1902494,GO:1902749,GO:1902750,GO:1903047,GO:1903076,GO:1903530,GO:1903532,GO:1903541,GO:1903543,GO:1903772,GO:1903774,GO:1903827,GO:1903900,GO:1903902,GO:1904375,GO:1904896,GO:1904903,GO:1904949,GO:1905475,GO:1990621	-	ko:K12196	ko04144,ko04217,map04144,map04217	M00412	-	-	ko00000,ko00001,ko00002,ko04131	-	-	-	AAA,MIT,Vps4_C
k141_946_1	263820.PTO1128	4.85e-27	110.0	COG0412@1|root,arCOG01659@2157|Archaea,2Y6XB@28890|Euryarchaeota,2422E@183967|Thermoplasmata	183967|Thermoplasmata	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
k141_45_1	1111134.HMPREF1253_0165	2.79e-57	184.0	COG0503@1|root,COG0503@2|Bacteria,1V1BV@1239|Firmicutes,24HGX@186801|Clostridia,22FYS@1570339|Peptoniphilaceae	186801|Clostridia	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
k141_1579_1	224325.AF_1029	1.06e-69	228.0	COG0318@1|root,arCOG00856@2157|Archaea,2XSZG@28890|Euryarchaeota,246KT@183980|Archaeoglobi	183980|Archaeoglobi	I	to SP P29212 GB L02649 GB X70994 PID 581070 GB U00096 percent identity	-	-	6.2.1.3	ko:K00666,ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
k141_317_1	742817.HMPREF9449_00118	7.42e-06	53.1	COG0491@1|root,COG0491@2|Bacteria,4NX5D@976|Bacteroidetes,2FTMK@200643|Bacteroidia	976|Bacteroidetes	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k141_2310_1	102107.XP_008246480.1	1.07e-94	292.0	COG0172@1|root,KOG2509@2759|Eukaryota,37IH8@33090|Viridiplantae,3G7DD@35493|Streptophyta,4JN3G@91835|fabids	35493|Streptophyta	J	Serine--tRNA	-	GO:0003674,GO:0003824,GO:0004812,GO:0004828,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006434,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010035,GO:0010038,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0042221,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046686,GO:0050896,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
k141_1676_1	1121405.dsmv_3415	2.82e-09	60.5	COG0537@1|root,COG0537@2|Bacteria,1PDTP@1224|Proteobacteria,42UAD@68525|delta/epsilon subdivisions,2WS0J@28221|Deltaproteobacteria	28221|Deltaproteobacteria	FG	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family	-	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
k141_779_1	283942.IL0784	1.05e-08	59.3	COG0500@1|root,COG2226@2|Bacteria,1N2R0@1224|Proteobacteria,1S422@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	COG0500 SAM-dependent methyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
k141_2311_1	1006581.GCW_02640	3.59e-18	88.2	COG0492@1|root,COG0492@2|Bacteria,3WT71@544448|Tenericutes	544448|Tenericutes	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k141_1763_1	1379698.RBG1_1C00001G0338	3.81e-48	175.0	COG0046@1|root,COG0046@2|Bacteria,2NNPS@2323|unclassified Bacteria	2|Bacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
k141_1677_1	326427.Cagg_1947	2.5e-30	120.0	COG0685@1|root,COG0685@2|Bacteria,2G7NU@200795|Chloroflexi,37699@32061|Chloroflexia	32061|Chloroflexia	C	PFAM methylenetetrahydrofolate reductase	-	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
k141_591_1	1415756.JQMY01000001_gene704	1.87e-24	104.0	COG0447@1|root,COG0447@2|Bacteria,1QTZ2@1224|Proteobacteria,2U0ZZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Belongs to the enoyl-CoA hydratase isomerase family. MenB subfamily	menB	-	-	ko:K07536	ko00362,ko01120,ko01220,map00362,map01120,map01220	M00540	R05592	RC01429	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
k141_1214_1	519989.ECTPHS_14004	2.22e-109	329.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,1RQP7@1236|Gammaproteobacteria,1WVZP@135613|Chromatiales	135613|Chromatiales	L	reverse transcriptase	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k141_948_1	760568.Desku_1478	8.03e-86	280.0	COG1148@1|root,COG1148@2|Bacteria,1V5YJ@1239|Firmicutes,248CC@186801|Clostridia	186801|Clostridia	C	binding domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Pyr_redox_2
k141_2312_1	768672.Desfe_1463	1.65e-121	362.0	COG5256@1|root,arCOG01561@2157|Archaea,2XPNT@28889|Crenarchaeota	28889|Crenarchaeota	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03231	ko03013,ko05134,map03013,map05134	-	-	-	ko00000,ko00001,ko03012,ko03016,ko03019,ko04131,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
k141_2039_1	234267.Acid_6003	0.000891	48.1	COG2251@1|root,COG3316@1|root,COG2251@2|Bacteria,COG3316@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Cas_Cas4,DDE_Tnp_IS66,HHH_5,RNase_H_2
k141_2744_2	428127.EUBDOL_00276	5.49e-15	73.9	COG2131@1|root,COG2131@2|Bacteria,1V3PU@1239|Firmicutes,3VQ7U@526524|Erysipelotrichia	526524|Erysipelotrichia	F	Cytidine and deoxycytidylate deaminase zinc-binding region	-	-	3.5.4.12	ko:K01493	ko00240,ko01100,map00240,map01100	M00429	R01663	RC00074	ko00000,ko00001,ko00002,ko01000,ko02044	-	-	-	dCMP_cyt_deam_1
k141_1138_1	1380346.JNIH01000009_gene1760	1.41e-10	66.6	COG2141@1|root,COG2141@2|Bacteria,2GMMJ@201174|Actinobacteria	201174|Actinobacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k141_781_1	1105031.HMPREF1141_1019	4.94e-49	176.0	COG3808@1|root,COG3808@2|Bacteria,1TNZI@1239|Firmicutes,248KS@186801|Clostridia,36G29@31979|Clostridiaceae	186801|Clostridia	C	Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
k141_2040_1	1499967.BAYZ01000016_gene6546	4.69e-30	122.0	COG0383@1|root,COG0383@2|Bacteria,2NQ98@2323|unclassified Bacteria	2|Bacteria	G	Alpha mannosidase, middle domain	mngB	GO:0003674,GO:0003824,GO:0004553,GO:0004559,GO:0005975,GO:0005996,GO:0006013,GO:0006464,GO:0006517,GO:0006807,GO:0008150,GO:0008152,GO:0009100,GO:0009987,GO:0015923,GO:0016787,GO:0016798,GO:0019318,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0071704,GO:1901135,GO:1901564	2.3.1.204,3.2.1.170,3.2.1.24	ko:K01191,ko:K15524,ko:K16869	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04131	-	GH38	iEcolC_1368.EcolC_2924,iSF_1195.SF0565,iSFxv_1172.SFxv_0623,iS_1188.S0578	Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C
k141_2313_1	760011.Spico_1044	1.82e-56	201.0	COG0006@1|root,COG0673@1|root,COG0006@2|Bacteria,COG0673@2|Bacteria,2J6T7@203691|Spirochaetes	203691|Spirochaetes	E	Oxidoreductase family, C-terminal alpha beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k141_145_1	1041930.Mtc_1154	1.04e-195	563.0	COG0443@1|root,arCOG03060@2157|Archaea,2XT86@28890|Euryarchaeota,2N91T@224756|Methanomicrobia	224756|Methanomicrobia	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
k141_1314_1	1327990.S0A059_9CAUD	9.17e-29	113.0	4QAIK@10239|Viruses,4QUPH@35237|dsDNA viruses  no RNA stage,4QPEB@28883|Caudovirales,4QNC3@10744|Podoviridae	10744|Podoviridae	S	endonuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_223_1	580340.Tlie_0291	2.1e-35	139.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,3T9VZ@508458|Synergistetes	508458|Synergistetes	H	PFAM Pterin binding enzyme	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Pterin_bind,S-methyl_trans
k141_2491_1	1144932.ATTF01000029_gene1035	2.33e-07	57.8	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2TS2B@28211|Alphaproteobacteria,4BP64@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	L	UvrD-like helicase C-terminal domain	uvrD	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k141_1403_1	644548.SCNU_06335	3.93e-11	68.2	COG0204@1|root,COG0204@2|Bacteria,2GJ6V@201174|Actinobacteria,4GA34@85026|Gordoniaceae	201174|Actinobacteria	I	Phosphate acyltransferases	plsC	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
k141_147_1	278957.ABEA03000195_gene532	2.28e-12	73.2	COG2211@1|root,COG2211@2|Bacteria	2|Bacteria	G	Major facilitator Superfamily	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2,MFS_3
k141_1679_1	314230.DSM3645_16115	2.17e-16	79.3	COG2131@1|root,COG2131@2|Bacteria,2J1FW@203682|Planctomycetes	203682|Planctomycetes	F	MafB19-like deaminase	-	-	-	-	-	-	-	-	-	-	-	-	dCMP_cyt_deam_1
k141_257_1	1094980.Mpsy_2482	1.24e-30	121.0	COG0826@1|root,arCOG03202@2157|Archaea,2XVHF@28890|Euryarchaeota,2N9HX@224756|Methanomicrobia	224756|Methanomicrobia	O	Peptidase family U32	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_U32
k141_1253_1	868131.MSWAN_0323	5.48e-66	212.0	COG1405@1|root,arCOG01981@2157|Archaea,2XT0Z@28890|Euryarchaeota,23NWZ@183925|Methanobacteria	183925|Methanobacteria	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfb	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
k141_258_1	34007.IT40_18480	5.43e-17	84.7	COG0160@1|root,COG0160@2|Bacteria,1MX0Y@1224|Proteobacteria,2TRAZ@28211|Alphaproteobacteria,2PX4S@265|Paracoccus	28211|Alphaproteobacteria	E	Aminotransferase class-III	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_3
k141_1888_2	1121129.KB903359_gene2548	3.64e-19	84.3	2AD08@1|root,312N7@2|Bacteria,4NYRC@976|Bacteroidetes,2FYTI@200643|Bacteroidia,230XM@171551|Porphyromonadaceae	976|Bacteroidetes	S	Holin of 3TMs, for gene-transfer release	-	-	-	-	-	-	-	-	-	-	-	-	GTA_holin_3TM
k141_2780_1	1382306.JNIM01000001_gene663	1.44e-24	110.0	COG2366@1|root,COG2366@2|Bacteria,2G63N@200795|Chloroflexi	200795|Chloroflexi	S	PFAM peptidase S45 penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
k141_1255_1	1121405.dsmv_2732	5.07e-08	59.7	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,42M5Q@68525|delta/epsilon subdivisions,2WIIX@28221|Deltaproteobacteria,2MIGT@213118|Desulfobacterales	28221|Deltaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
k141_1257_1	1114970.PSF113_1925	6.32e-44	157.0	COG5421@1|root,COG5421@2|Bacteria,1QUUP@1224|Proteobacteria,1T21N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	to Shigella flexneri,and Shigella flexneri 2A IS10 orf S0034 or Cp0027 SWALL Q9AFX7 (EMBL AF348706) (407 aa) fasta scores E()	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k141_1258_1	1448860.BBJO01000024_gene3108	3.06e-32	128.0	COG0459@1|root,arCOG01257@2157|Archaea,2XTMS@28890|Euryarchaeota,23T6B@183963|Halobacteria	183963|Halobacteria	O	Belongs to the TCP-1 chaperonin family	thsB	-	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
k141_264_1	13037.EHJ74015	2.88e-15	81.6	KOG1075@1|root,KOG1075@2759|Eukaryota,3AQAX@33154|Opisthokonta,3C23C@33208|Metazoa,3DI9Q@33213|Bilateria,422W7@6656|Arthropoda	33208|Metazoa	S	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2
k141_1964_1	909663.KI867150_gene485	4.73e-40	149.0	COG1148@1|root,COG1148@2|Bacteria,1N26U@1224|Proteobacteria,43EWE@68525|delta/epsilon subdivisions,2X2B6@28221|Deltaproteobacteria,2MRJK@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
k141_2057_1	634498.mru_1600	1.98e-39	145.0	COG1405@1|root,arCOG01981@2157|Archaea,2XT0Z@28890|Euryarchaeota,23NWZ@183925|Methanobacteria	28890|Euryarchaeota	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfb	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
k141_166_1	457398.HMPREF0326_03001	7.18e-05	48.5	COG0778@1|root,COG0778@2|Bacteria,1PFUU@1224|Proteobacteria,435WP@68525|delta/epsilon subdivisions,2X0D1@28221|Deltaproteobacteria,2MBVD@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
k141_1051_1	387631.Asulf_02117	4.55e-75	237.0	COG1060@1|root,arCOG00656@2157|Archaea,2XU6S@28890|Euryarchaeota,245QQ@183980|Archaeoglobi	183980|Archaeoglobi	H	Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO)	cofH	-	2.5.1.77	ko:K11781	ko00680,ko01120,map00680,map01120	M00378	R09396	RC01381,RC03002,RC03007	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
k141_893_1	95619.PM1_0228610	3.42e-25	109.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k141_332_1	573063.Metin_0594	2.77e-30	116.0	COG1051@1|root,arCOG01075@2157|Archaea,2XXS4@28890|Euryarchaeota,23R1E@183939|Methanococci	183939|Methanococci	F	PFAM NUDIX hydrolase	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
k141_1328_1	266117.Rxyl_2349	2.99e-33	129.0	COG3119@1|root,COG3119@2|Bacteria,2GJ8H@201174|Actinobacteria	201174|Actinobacteria	P	Pfam Sulfatase	atsG	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
k141_519_1	1047013.AQSP01000114_gene701	1.72e-84	256.0	COG2885@1|root,COG2885@2|Bacteria	2|Bacteria	M	chlorophyll binding	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
k141_2673_1	1499967.BAYZ01000180_gene4412	4.68e-72	235.0	COG0334@1|root,COG0517@1|root,COG0334@2|Bacteria,COG0517@2|Bacteria	2|Bacteria	S	IMP dehydrogenase activity	aer	-	1.4.1.2	ko:K03406,ko:K15371	ko00220,ko00250,ko00430,ko00910,ko01100,ko02020,ko02030,map00220,map00250,map00430,map00910,map01100,map02020,map02030	-	R00243	RC00006,RC02799	ko00000,ko00001,ko01000,ko02035	-	-	-	CBS,HATPase_c,HisKA,MCPsignal,Response_reg,SpoIIE
k141_1156_1	933262.AXAM01000057_gene1546	7.71e-43	149.0	COG3568@1|root,COG3568@2|Bacteria,1PPNP@1224|Proteobacteria,42QW2@68525|delta/epsilon subdivisions,2WMRN@28221|Deltaproteobacteria,2MJIW@213118|Desulfobacterales	28221|Deltaproteobacteria	L	PFAM Endonuclease Exonuclease phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
k141_234_2	339860.Msp_0668	1.04e-13	73.2	COG1035@1|root,arCOG02650@2157|Archaea,2Y2D2@28890|Euryarchaeota,23PDV@183925|Methanobacteria	183925|Methanobacteria	C	PFAM Coenzyme F420 hydrogenase dehydrogenase beta subunit	frhB2	-	1.12.98.1	ko:K00441	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	R03025	RC02628	ko00000,ko00001,ko01000	-	-	-	Fer4,FrhB_FdhB_C,FrhB_FdhB_N
k141_333_1	598467.BrE312_1829	1.43e-05	50.1	COG0451@1|root,COG0451@2|Bacteria,1PB4Y@1224|Proteobacteria,1RZTV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
k141_1595_1	313606.M23134_01006	6.16e-09	63.9	COG1233@1|root,COG1233@2|Bacteria,4NG5Y@976|Bacteroidetes,47K5X@768503|Cytophagia	976|Bacteroidetes	Q	Flavin containing amine oxidoreductase	-	-	1.3.99.23	ko:K09516	ko00830,map00830	-	R07163	RC01835	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase,NAD_binding_8
k141_603_1	907348.TresaDRAFT_0077	8.72e-43	158.0	COG0272@1|root,COG0272@2|Bacteria,2J57Q@203691|Spirochaetes	203691|Spirochaetes	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
k141_2579_1	420247.Msm_0287	2.05e-41	151.0	COG0008@1|root,arCOG00402@2157|Archaea,2XSUM@28890|Euryarchaeota,23NMX@183925|Methanobacteria	183925|Methanobacteria	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
k141_2420_1	931626.Awo_c12750	5.46e-92	290.0	COG0579@1|root,COG1251@1|root,COG0579@2|Bacteria,COG1251@2|Bacteria,1TRDH@1239|Firmicutes,248IK@186801|Clostridia,25V7H@186806|Eubacteriaceae	186801|Clostridia	P	FAD dependent oxidoreductase	glpA	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,Fer2_BFD
k141_1861_1	224719.Abm4_1723	9.74e-46	162.0	COG0043@1|root,arCOG01671@2157|Archaea,2XUDW@28890|Euryarchaeota,23NKJ@183925|Methanobacteria	183925|Methanobacteria	H	3-octaprenyl-4-hydroxybenzoate carboxy-lyase	-	-	-	-	-	-	-	-	-	-	-	-	UbiD
k141_1420_1	907348.TresaDRAFT_0077	3.09e-45	165.0	COG0272@1|root,COG0272@2|Bacteria,2J57Q@203691|Spirochaetes	203691|Spirochaetes	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
k141_334_1	246194.CHY_2037	2.1e-40	157.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1TPG1@1239|Firmicutes,25ETM@186801|Clostridia,42I7T@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG
k141_2501_1	706587.Desti_5359	5.36e-47	169.0	COG0247@1|root,COG0247@2|Bacteria,1MUMH@1224|Proteobacteria,42N5J@68525|delta/epsilon subdivisions,2WJ6B@28221|Deltaproteobacteria,2MR3T@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Cysteine-rich domain	-	-	1.8.98.1	ko:K08264	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	-	R04540	RC00011	ko00000,ko00001,ko01000	-	-	-	CCG
k141_2134_1	485916.Dtox_0523	8e-07	60.1	COG5421@1|root,COG5421@2|Bacteria,1TPAA@1239|Firmicutes,2492T@186801|Clostridia	186801|Clostridia	L	PFAM Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k141_1053_2	1123290.AUDQ01000020_gene697	8.09e-10	62.0	COG4974@1|root,COG4974@2|Bacteria,1TQXV@1239|Firmicutes,4HD04@91061|Bacilli,26ERV@186818|Planococcaceae	91061|Bacilli	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_int_SAM_4,Phage_integrase
k141_335_1	1232437.KL662050_gene5380	3.36e-89	280.0	COG1274@1|root,COG1274@2|Bacteria,1MX3C@1224|Proteobacteria,42PRT@68525|delta/epsilon subdivisions,2WIWH@28221|Deltaproteobacteria,2MIPZ@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Phosphoenolpyruvate carboxykinase N-terminal domain	pckG	-	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2638	PEPCK_C,PEPCK_N
k141_1157_1	13616.ENSMODP00000023387	6.24e-22	91.7	COG5262@1|root,KOG1756@2759|Eukaryota,3AU9G@33154|Opisthokonta,3CQ9D@33208|Metazoa	33208|Metazoa	B	Histone H2A	-	GO:0000228,GO:0000785,GO:0000790,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005694,GO:0006325,GO:0006342,GO:0006355,GO:0006996,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016043,GO:0016458,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031974,GO:0031981,GO:0040029,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044454,GO:0044464,GO:0045814,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051276,GO:0060255,GO:0065007,GO:0070013,GO:0071840,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K11251	ko04217,ko05034,ko05322,map04217,map05034,map05322	-	-	-	ko00000,ko00001,ko03036,ko04147	-	-	-	Histone,Histone_H2A_C
k141_433_1	1089553.Tph_c24780	6.77e-71	234.0	COG2871@1|root,COG3894@1|root,COG2871@2|Bacteria,COG3894@2|Bacteria,1TP0H@1239|Firmicutes,247S0@186801|Clostridia,42F3G@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
k141_1225_3	875328.JDM601_1365	1.17e-25	105.0	COG1573@1|root,COG1573@2|Bacteria,2HS2P@201174|Actinobacteria,23A9P@1762|Mycobacteriaceae	201174|Actinobacteria	L	Uracil DNA glycosylase superfamily	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
k141_605_1	317619.ANKN01000077_gene2314	4.94e-13	72.4	COG2199@1|root,COG3706@2|Bacteria	2|Bacteria	T	GGDEF domain	-	-	2.7.13.3	ko:K11527	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HATPase_c,Response_reg
k141_1862_2	552811.Dehly_0627	4.46e-14	75.1	COG0674@1|root,COG0674@2|Bacteria,2G5M1@200795|Chloroflexi,34CZQ@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Pyruvate:ferredoxin oxidoreductase core domain II	porA	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
k141_1226_2	744980.TRICHSKD4_5792	2.07e-09	62.0	COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,2TRVA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG2826 Transposase and inactivated derivatives, IS30 family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_38,rve
k141_168_1	913865.DOT_1406	1.73e-33	131.0	COG0477@1|root,COG2814@2|Bacteria,1TPRN@1239|Firmicutes,249RZ@186801|Clostridia,263IU@186807|Peptococcaceae	186801|Clostridia	U	TIGRFAM drug resistance transporter, EmrB QacA subfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
k141_1330_1	304371.MCP_0389	4.38e-47	167.0	arCOG11014@1|root,arCOG11014@2157|Archaea,2XZ0A@28890|Euryarchaeota	2157|Archaea	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
k141_2136_1	56780.SYN_02439	6.31e-67	218.0	COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,42MCI@68525|delta/epsilon subdivisions,2WJ7H@28221|Deltaproteobacteria,2MQ82@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Phosphoribosylglycinamide synthetase, C domain	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
k141_434_1	861299.J421_6139	1.83e-10	66.6	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k141_2759_1	604354.TSIB_1789	5.67e-31	125.0	COG0013@1|root,arCOG01254@2157|Archaea,2XZ9G@28890|Euryarchaeota,243MX@183968|Thermococci	183968|Thermococci	J	alanyl-tRNA	-	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
k141_2675_1	416591.Tlet_0046	2.35e-27	117.0	COG2211@1|root,COG2211@2|Bacteria,2GDVW@200918|Thermotogae	200918|Thermotogae	G	MFS/sugar transport protein	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
k141_2675_2	1384049.CD29_07355	0.000108	43.5	COG0626@1|root,COG0626@2|Bacteria,1TPC7@1239|Firmicutes,4IS7E@91061|Bacilli	91061|Bacilli	E	methionine gamma-lyase	-	-	4.4.1.11	ko:K01761	ko00270,ko00450,map00270,map00450	-	R00654,R04770	RC00196,RC00348,RC01209,RC01210	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
k141_2423_1	387631.Asulf_02182	1.43e-45	168.0	COG2414@1|root,arCOG00706@2157|Archaea,2XWCH@28890|Euryarchaeota,245R8@183980|Archaeoglobi	183980|Archaeoglobi	C	Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
k141_705_1	29730.Gorai.001G229200.1	2.99e-27	113.0	COG1100@1|root,KOG0087@2759|Eukaryota,37KFT@33090|Viridiplantae,3GB3F@35493|Streptophyta	35493|Streptophyta	U	Ras-related protein	-	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005794,GO:0005795,GO:0005798,GO:0005802,GO:0005829,GO:0005886,GO:0006810,GO:0006891,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0012505,GO:0016020,GO:0016192,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0031410,GO:0031982,GO:0031984,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044431,GO:0044444,GO:0044446,GO:0044464,GO:0048193,GO:0048219,GO:0050896,GO:0051179,GO:0051234,GO:0071944,GO:0097159,GO:0097367,GO:0097708,GO:0098791,GO:1901265,GO:1901363	-	ko:K07904,ko:K07976	ko04144,ko04961,ko04962,ko04972,map04144,map04961,map04962,map04972	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
k141_2327_2	675813.VIB_002946	3.31e-134	401.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,1RQP7@1236|Gammaproteobacteria,1XVS8@135623|Vibrionales	135623|Vibrionales	L	Group II intron, maturase-specific domain	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k141_2676_1	246969.TAM4_1772	6.72e-73	239.0	COG1782@1|root,arCOG00543@2157|Archaea,2XTIM@28890|Euryarchaeota,243E8@183968|Thermococci	183968|Thermococci	S	Beta-Casp domain	-	-	-	ko:K07041	-	-	-	-	ko00000	-	-	-	Beta-Casp,KH_7,Lactamase_B,Lactamase_B_6,RMMBL
k141_798_1	1207063.P24_15129	3.9e-18	89.0	COG0616@1|root,COG0616@2|Bacteria,1QGPW@1224|Proteobacteria,2U2TT@28211|Alphaproteobacteria,2JTF6@204441|Rhodospirillales	204441|Rhodospirillales	OU	Peptidase family S49	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S49
k141_1969_1	709986.Deima_2549	7.5e-57	189.0	COG1960@1|root,COG1960@2|Bacteria,1WICM@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	PFAM Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k141_66_1	493475.GARC_1404	2.03e-90	277.0	COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,1RMF9@1236|Gammaproteobacteria,464W8@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	COG3547 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k141_805_1	1121948.AUAC01000003_gene2773	2.24e-17	87.0	COG2070@1|root,COG2070@2|Bacteria,1MWPC@1224|Proteobacteria,2VFGV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Nitronate monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	NMO
k141_2586_1	2340.JV46_28950	3.23e-52	196.0	2DY5I@1|root,3488J@2|Bacteria,1P3B4@1224|Proteobacteria	1224|Proteobacteria	S	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k141_2333_1	138119.DSY3991	7.14e-59	198.0	COG3385@1|root,COG3385@2|Bacteria,1TSH6@1239|Firmicutes,24A21@186801|Clostridia,2619N@186807|Peptococcaceae	186801|Clostridia	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5,DDE_Tnp_1
k141_2233_1	1365176.N186_02340	2.63e-89	292.0	COG0085@1|root,arCOG01762@2157|Archaea,2XPRW@28889|Crenarchaeota	28889|Crenarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K13798	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_4,RNA_pol_Rpb2_5,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k141_68_1	439235.Dalk_2834	0.000571	41.6	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,43B2Q@68525|delta/epsilon subdivisions,2WK38@28221|Deltaproteobacteria,2MJTZ@213118|Desulfobacterales	28221|Deltaproteobacteria	C	FAD linked oxidases, C-terminal domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
k141_68_2	56780.SYN_01166	2.33e-33	128.0	COG0247@1|root,COG0247@2|Bacteria,1MUMH@1224|Proteobacteria,42N5J@68525|delta/epsilon subdivisions,2WJ6B@28221|Deltaproteobacteria,2MR3T@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Cysteine-rich domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
k141_2066_1	868595.Desca_0130	1.76e-46	171.0	COG1148@1|root,COG1149@1|root,COG1148@2|Bacteria,COG1149@2|Bacteria,1V5YJ@1239|Firmicutes,248CC@186801|Clostridia,260ZH@186807|Peptococcaceae	186801|Clostridia	C	binding domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_9,NAD_binding_8,Pyr_redox_2
k141_1061_1	1005058.UMN179_00244	5.5e-33	124.0	COG0491@1|root,COG0491@2|Bacteria,1MUDN@1224|Proteobacteria,1RMMG@1236|Gammaproteobacteria,1Y7RJ@135625|Pasteurellales	135625|Pasteurellales	S	glyoxalase II family protein	Z012_03820	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k141_1608_1	96561.Dole_2695	9.14e-78	254.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,2MJ5T@213118|Desulfobacterales	28221|Deltaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon-2	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k141_2513_1	879305.HMPREF9290_1534	6.27e-52	172.0	COG0149@1|root,COG0149@2|Bacteria,1TP2F@1239|Firmicutes,248JN@186801|Clostridia,22G1N@1570339|Peptoniphilaceae	186801|Clostridia	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iHN637.CLJU_RS19265	TIM
k141_243_1	67593.Physo137253	2.17e-92	311.0	COG2801@1|root,2RRWG@2759|Eukaryota,3QH6N@4776|Peronosporales	4776|Peronosporales	L	transposition	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_2588_1	1041930.Mtc_2309	7.78e-15	77.8	COG1938@1|root,arCOG00347@2157|Archaea,2XT93@28890|Euryarchaeota,2N9KT@224756|Methanomicrobia	224756|Methanomicrobia	S	PAC2 family	-	-	-	ko:K06869	-	-	-	-	ko00000	-	-	-	PAC2
k141_341_1	88036.EFJ13554	1.38e-41	154.0	COG0477@1|root,KOG1330@2759|Eukaryota,37N1A@33090|Viridiplantae,3GBIN@35493|Streptophyta	35493|Streptophyta	G	Major facilitator superfamily protein	-	GO:0000003,GO:0000323,GO:0002165,GO:0003006,GO:0003376,GO:0003674,GO:0005215,GO:0005319,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005764,GO:0005765,GO:0005768,GO:0005770,GO:0005773,GO:0005774,GO:0006810,GO:0006869,GO:0006897,GO:0006915,GO:0006928,GO:0006950,GO:0006996,GO:0007033,GO:0007034,GO:0007040,GO:0007041,GO:0007154,GO:0007165,GO:0007186,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007399,GO:0007416,GO:0007417,GO:0007528,GO:0007610,GO:0007617,GO:0007618,GO:0007619,GO:0008150,GO:0008219,GO:0008333,GO:0008347,GO:0008582,GO:0009267,GO:0009605,GO:0009653,GO:0009791,GO:0009886,GO:0009966,GO:0009968,GO:0009987,GO:0009991,GO:0010001,GO:0010008,GO:0010623,GO:0010646,GO:0010648,GO:0010876,GO:0010941,GO:0012501,GO:0012505,GO:0016020,GO:0016043,GO:0016192,GO:0016477,GO:0019098,GO:0019953,GO:0022008,GO:0022412,GO:0022414,GO:0022607,GO:0023051,GO:0023052,GO:0023057,GO:0030154,GO:0031090,GO:0031410,GO:0031667,GO:0031668,GO:0031669,GO:0031902,GO:0031982,GO:0032501,GO:0032502,GO:0032504,GO:0033036,GO:0033554,GO:0035193,GO:0036465,GO:0040007,GO:0040008,GO:0040011,GO:0042063,GO:0042594,GO:0042981,GO:0043067,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043900,GO:0044085,GO:0044087,GO:0044422,GO:0044424,GO:0044433,GO:0044437,GO:0044440,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0045476,GO:0045477,GO:0045595,GO:0045924,GO:0046624,GO:0046907,GO:0048468,GO:0048477,GO:0048488,GO:0048519,GO:0048523,GO:0048583,GO:0048585,GO:0048589,GO:0048609,GO:0048638,GO:0048731,GO:0048856,GO:0048869,GO:0048870,GO:0050789,GO:0050793,GO:0050794,GO:0050803,GO:0050807,GO:0050808,GO:0050896,GO:0051124,GO:0051128,GO:0051179,GO:0051234,GO:0051239,GO:0051641,GO:0051649,GO:0051674,GO:0051704,GO:0051716,GO:0051960,GO:0051963,GO:0060180,GO:0060284,GO:0065007,GO:0065008,GO:0071496,GO:0071702,GO:0071840,GO:0080171,GO:0090092,GO:0090097,GO:0090099,GO:0090101,GO:0090520,GO:0097708,GO:0098588,GO:0098657,GO:0098805,GO:0098852,GO:0099003,GO:0099504,GO:1902742,GO:1904396,GO:1904748,GO:1905879,GO:2000026,GO:2000241	-	-	-	-	-	-	-	-	-	-	MFS_1
k141_2688_2	649747.HMPREF0083_00148	7.98e-12	68.6	COG1695@1|root,COG1695@2|Bacteria,1VGWC@1239|Firmicutes,4HNZJ@91061|Bacilli,26WWT@186822|Paenibacillaceae	91061|Bacilli	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
k141_2144_1	1343739.PAP_10275	5.3e-43	153.0	COG0468@1|root,arCOG00415@2157|Archaea,2XT80@28890|Euryarchaeota,242UY@183968|Thermococci	183968|Thermococci	L	Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules	radA	GO:0000150,GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0000730,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006312,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0033554,GO:0034622,GO:0034641,GO:0042148,GO:0042623,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0045003,GO:0046483,GO:0050896,GO:0051716,GO:0065003,GO:0065004,GO:0071704,GO:0071824,GO:0071840,GO:0090304,GO:0090735,GO:0097159,GO:0140097,GO:1901360,GO:1901363	-	ko:K04483	-	-	-	-	ko00000,ko03400	-	-	-	HHH_5,Intein_splicing,LAGLIDADG_3,Rad51
k141_1334_1	1220534.B655_0610	2.8e-60	209.0	COG1933@1|root,arCOG04447@2157|Archaea,2XU5S@28890|Euryarchaeota,23NX8@183925|Methanobacteria	183925|Methanobacteria	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polC	-	2.7.7.7	ko:K02322	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	PolC_DP2
k141_70_1	1231241.Mc24_07764	2.16e-10	68.2	COG0438@1|root,COG0438@2|Bacteria,2GCQU@200918|Thermotogae	200918|Thermotogae	M	PFAM glycosyl transferase group 1	-	-	2.4.1.337	ko:K19002	ko00561,ko01100,map00561,map01100	-	R10850	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
k141_1162_1	96561.Dole_2099	5.38e-12	62.0	2AB4Z@1|root,32TK9@2|Bacteria,1N53W@1224|Proteobacteria,42U1B@68525|delta/epsilon subdivisions,2X6XZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_1162_2	246200.SPO1722	0.000141	43.9	COG1802@1|root,COG1802@2|Bacteria,1MWG2@1224|Proteobacteria,2TS8A@28211|Alphaproteobacteria,4NCS6@97050|Ruegeria	28211|Alphaproteobacteria	K	FCD	-	-	-	ko:K22293	-	-	-	-	ko00000,ko03000	-	-	-	FCD,GntR
k141_2689_1	204773.HEAR3032	1.12e-08	58.9	COG1846@1|root,COG1846@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24,MarR_2,ROK,RadC
k141_2764_4	1291050.JAGE01000001_gene2910	5.72e-18	82.4	2EGZP@1|root,33ART@2|Bacteria	2|Bacteria	S	YopX protein	-	-	-	-	-	-	-	-	-	-	-	-	YopX
k141_71_1	436308.Nmar_1518	2.76e-19	83.6	arCOG04405@1|root,arCOG04405@2157|Archaea	2157|Archaea	S	ASCH domain	-	-	-	-	-	-	-	-	-	-	-	-	ASCH
k141_2068_1	1267535.KB906767_gene4705	3.53e-78	257.0	COG3387@1|root,COG3387@2|Bacteria,3Y385@57723|Acidobacteria,2JHYN@204432|Acidobacteriia	204432|Acidobacteriia	G	Glucodextranase, domain N	-	-	3.2.1.3	ko:K01178	ko00500,ko01100,map00500,map01100	-	R01790,R01791,R06199	-	ko00000,ko00001,ko01000	-	GH15	-	Glucodextran_N,Glyco_hydro_15
k141_1335_2	1121459.AQXE01000013_gene2186	3.66e-11	61.6	COG3926@1|root,COG3926@2|Bacteria,1MVXW@1224|Proteobacteria,42X4V@68525|delta/epsilon subdivisions,2WSN4@28221|Deltaproteobacteria,2MD5R@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Predicted Peptidoglycan domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_108,PG_binding_3
k141_2235_1	1056820.KB900681_gene2859	1.06e-106	319.0	COG3385@1|root,COG3385@2|Bacteria,1PMXF@1224|Proteobacteria,1RMHK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	COG3385 FOG Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4372
k141_1163_1	694429.Pyrfu_1810	5.76e-63	208.0	COG1498@1|root,arCOG01923@2157|Archaea,2XPYC@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM Pre-mRNA processing ribonucleoprotein, binding	-	-	-	ko:K14564	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	Nop
k141_2690_1	647113.Metok_0747	1.68e-96	306.0	COG1152@1|root,arCOG02428@2157|Archaea,2XTBY@28890|Euryarchaeota,23Q9D@183939|Methanococci	183939|Methanococci	C	Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase	cdhA	GO:0000302,GO:0003674,GO:0003824,GO:0004601,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016661,GO:0016684,GO:0042221,GO:0042493,GO:0042542,GO:0046677,GO:0050418,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1990748	1.2.7.4	ko:K00192	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00422	R07157	RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_7,Fer4_9,Prismane
k141_342_1	272563.CD630_13800	1.77e-05	52.4	COG0477@1|root,COG1511@1|root,COG0477@2|Bacteria,COG1511@2|Bacteria,1TPHW@1239|Firmicutes,2492B@186801|Clostridia,25UJM@186804|Peptostreptococcaceae	186801|Clostridia	EGP	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k141_72_1	7425.NV17450-PA	4.05e-07	57.4	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,41WI3@6656|Arthropoda,3SIRK@50557|Insecta,46IFZ@7399|Hymenoptera	33208|Metazoa	L	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	Baculo_F,RVT_1,rve
k141_529_1	1329516.JPST01000011_gene368	0.000326	48.9	COG3378@1|root,COG3378@2|Bacteria,1TQP9@1239|Firmicutes,4HBTB@91061|Bacilli,27CQQ@186824|Thermoactinomycetaceae	91061|Bacilli	S	D5 N terminal like	-	-	-	ko:K06919	-	-	-	-	ko00000	-	-	-	D5_N,Pox_D5,PriCT_1,Prim-Pol
k141_2334_1	880073.Calab_0167	6.59e-46	166.0	COG5421@1|root,COG5421@2|Bacteria,2NQ27@2323|unclassified Bacteria	2|Bacteria	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2
k141_716_2	1449351.RISW2_11665	0.000392	48.5	COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,2TSYI@28211|Alphaproteobacteria,4KMA4@93682|Roseivivax	28211|Alphaproteobacteria	U	Phosphate transporter family	pitA	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
k141_729_1	996306.SSUR61_1196	5.77e-31	119.0	COG3547@1|root,COG3547@2|Bacteria,1V427@1239|Firmicutes,4HGY6@91061|Bacilli,1WTUH@1307|Streptococcus suis	91061|Bacilli	L	Transposase IS116/IS110/IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k141_2266_1	767817.Desgi_2043	3.99e-52	177.0	COG1143@1|root,COG1143@2|Bacteria,1UJ43@1239|Firmicutes,25EVE@186801|Clostridia,2605I@186807|Peptococcaceae	186801|Clostridia	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	asrA	-	-	ko:K16950	ko00920,ko01120,map00920,map01120	-	R00858,R10146	RC00065	ko00000,ko00001	-	-	-	Fer4_22
k141_2444_1	1215092.PA6_014_00270	0.000756	44.3	2DNYX@1|root,32ZUH@2|Bacteria,1N3P2@1224|Proteobacteria,1S9BR@1236|Gammaproteobacteria,1YHFX@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	Bacteriophage lambda head decoration protein D	-	-	-	-	-	-	-	-	-	-	-	-	HDPD
k141_1900_1	1380391.JIAS01000001_gene2574	4.4e-32	127.0	COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,2TRS3@28211|Alphaproteobacteria,2JPJC@204441|Rhodospirillales	204441|Rhodospirillales	G	Alpha-amylase domain	-	-	3.2.1.1,3.2.1.10,3.2.1.20,5.4.99.16	ko:K01182,ko:K01187,ko:K05343	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R01557,R01718,R01791,R02108,R02112,R06087,R06088,R06199,R11262	RC00028,RC00049,RC00059,RC00077,RC00451,RC01816	ko00000,ko00001,ko01000	-	GH13,GH31	-	Alpha-amylase,DUF3459,Malt_amylase_C
k141_2817_1	926556.Echvi_3203	6.99e-95	291.0	COG3385@1|root,COG5421@1|root,COG3385@2|Bacteria,COG5421@2|Bacteria,4NXT2@976|Bacteroidetes	976|Bacteroidetes	L	hmm pf01609	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k141_193_1	1232437.KL662061_gene4167	6.61e-22	101.0	COG1148@1|root,COG1232@1|root,COG1908@1|root,COG1148@2|Bacteria,COG1232@2|Bacteria,COG1908@2|Bacteria,1MYFK@1224|Proteobacteria,42SXF@68525|delta/epsilon subdivisions,2WPYS@28221|Deltaproteobacteria,2MQ2E@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Methyl-viologen-reducing hydrogenase, delta subunit	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,FlpD,Pyr_redox_2
k141_559_1	272624.lpg0067	2.53e-09	60.5	COG3545@1|root,COG3545@2|Bacteria,1RKTI@1224|Proteobacteria	1224|Proteobacteria	S	esterase of the alpha beta hydrolase fold	ydeN	-	-	ko:K07002	-	-	-	-	ko00000	-	-	-	Ser_hydrolase
k141_2003_1	96561.Dole_1150	7.56e-20	94.4	COG1035@1|root,COG1146@1|root,COG1035@2|Bacteria,COG1146@2|Bacteria,1MWJC@1224|Proteobacteria,42QB3@68525|delta/epsilon subdivisions,2WM0Q@28221|Deltaproteobacteria,2MIXS@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Coenzyme F420 hydrogenase dehydrogenase, beta subunit	-	-	1.12.98.1	ko:K00441	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	R03025	RC02628	ko00000,ko00001,ko01000	-	-	-	Fer4,Fer4_10,FrhB_FdhB_C,FrhB_FdhB_N
k141_2359_1	926567.TheveDRAFT_0395	3.52e-69	225.0	COG0065@1|root,COG0065@2|Bacteria,3TA6N@508458|Synergistetes	508458|Synergistetes	H	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
k141_1542_1	439235.Dalk_4039	7.31e-20	97.1	COG0277@1|root,COG0277@2|Bacteria,1NUIU@1224|Proteobacteria	2|Bacteria	C	FAD binding domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	BBE,FAD_binding_4
k141_1468_1	459349.CLOAM0341	1.13e-107	318.0	COG0588@1|root,COG0588@2|Bacteria,2NQEI@2323|unclassified Bacteria	2|Bacteria	G	Phosphoglycerate mutase family	gpmA	GO:0003674,GO:0003824,GO:0004619,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009987,GO:0010675,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0031323,GO:0031329,GO:0032787,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0055086,GO:0060255,GO:0062012,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031	5.4.2.11	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
k141_2183_1	4530.OS11T0656500-01	3.94e-29	129.0	COG2801@1|root,KOG0017@2759|Eukaryota,37THH@33090|Viridiplantae,3GG2K@35493|Streptophyta,3M2IR@4447|Liliopsida,3IKX9@38820|Poales	35493|Streptophyta	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_2,rve
k141_1543_1	1408473.JHXO01000007_gene736	1.53e-27	117.0	COG1148@1|root,COG1148@2|Bacteria,4NI95@976|Bacteroidetes,2FRRV@200643|Bacteroidia	976|Bacteroidetes	C	NAD(P)-binding Rossmann-like domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,HI0933_like,Pyr_redox_2
k141_561_1	289376.THEYE_A1366	3.87e-23	101.0	COG1941@1|root,COG1941@2|Bacteria	2|Bacteria	C	coenzyme F420 hydrogenase activity	-	-	1.8.98.5	ko:K14128	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	Fe_hyd_lg_C,Fer4,Oxidored_q6
k141_2184_1	313606.M23134_02244	4.11e-54	178.0	2AU0F@1|root,31JKB@2|Bacteria,4NHS6@976|Bacteroidetes,47Q5C@768503|Cytophagia	976|Bacteroidetes	S	COG NOG14600 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_1101_1	1540257.JQMW01000009_gene2681	1.13e-75	240.0	COG3344@1|root,COG3344@2|Bacteria,1TP9A@1239|Firmicutes,248M4@186801|Clostridia,36F7Z@31979|Clostridiaceae	186801|Clostridia	L	Reverse transcriptase	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k141_2820_1	333138.LQ50_00840	0.00038	48.5	COG0358@1|root,COG0358@2|Bacteria,1TQ0X@1239|Firmicutes,4HAG2@91061|Bacilli,1ZC16@1386|Bacillus	91061|Bacilli	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
k141_1911_1	1384057.CD33_09995	1.84e-56	184.0	COG1126@1|root,COG1126@2|Bacteria,1TNYD@1239|Firmicutes,4H9WY@91061|Bacilli,3IWI6@400634|Lysinibacillus	91061|Bacilli	E	Peptide ABC transporter ATP-binding protein	-	-	3.6.3.21	ko:K02028	-	M00236	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.3	-	-	ABC_tran
k141_1006_1	315749.Bcer98_3545	3.9e-43	151.0	COG0253@1|root,COG0253@2|Bacteria,1TPMN@1239|Firmicutes,4HBH4@91061|Bacilli,1ZD98@1386|Bacillus	91061|Bacilli	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
k141_1469_1	997346.HMPREF9374_0005	6.18e-34	127.0	COG1024@1|root,COG1024@2|Bacteria,1TQ2V@1239|Firmicutes,4HBT0@91061|Bacilli,27B90@186824|Thermoactinomycetaceae	91061|Bacilli	I	Enoyl-CoA hydratase/isomerase	-	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
k141_654_1	926560.KE387023_gene2199	2.57e-18	87.4	COG0637@1|root,COG0637@2|Bacteria,1WNGW@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	HAD-hyrolase-like	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
k141_2361_1	584708.Apau_0038	3.55e-94	296.0	COG1048@1|root,COG1048@2|Bacteria,3TA17@508458|Synergistetes	508458|Synergistetes	C	TIGRFAM aconitate hydratase	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k141_1102_1	999630.TUZN_0503	2.06e-43	160.0	COG1964@1|root,arCOG00933@2157|Archaea,2XPQM@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM Radical SAM domain protein	-	-	-	ko:K06937	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Fer4_14,Radical_SAM
k141_1635_1	419665.Maeo_0027	1.39e-68	220.0	COG0182@1|root,arCOG01123@2157|Archaea,2Y86P@28890|Euryarchaeota,23QJA@183939|Methanococci	183939|Methanococci	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	-	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
k141_1814_1	2754.EH55_09060	4.72e-30	122.0	COG2414@1|root,COG2414@2|Bacteria,3TAIF@508458|Synergistetes	508458|Synergistetes	C	PFAM Aldehyde ferredoxin oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	AFOR_C,AFOR_N
k141_1376_1	887898.HMPREF0551_1992	5.64e-88	271.0	COG3464@1|root,COG3464@2|Bacteria,1N2V1@1224|Proteobacteria,2VJ9Z@28216|Betaproteobacteria	28216|Betaproteobacteria	L	similarity to OMNI NTL01RS2573	-	-	-	ko:K07485	-	-	-	-	ko00000	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3
k141_111_2	1291050.JAGE01000001_gene2907	8.03e-67	216.0	COG0175@1|root,COG0175@2|Bacteria,1TSMI@1239|Firmicutes,24A18@186801|Clostridia	186801|Clostridia	EH	Phosphoadenosine phosphosulfate reductase	-	-	-	-	-	-	-	-	-	-	-	-	PAPS_reduct
k141_1470_1	1121396.KB893058_gene2553	5.35e-66	213.0	COG1304@1|root,COG1304@2|Bacteria,1MUEZ@1224|Proteobacteria,42N2F@68525|delta/epsilon subdivisions,2WIZ8@28221|Deltaproteobacteria,2MIW8@213118|Desulfobacterales	28221|Deltaproteobacteria	C	FMN-dependent dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_dh
k141_738_1	1151117.AJLF01000001_gene784	3.83e-75	245.0	COG1274@1|root,arCOG05865@2157|Archaea,2XUU1@28890|Euryarchaeota,24380@183968|Thermococci	183968|Thermococci	C	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	-	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_C,PEPCK_N
k141_2362_1	96561.Dole_3185	4.01e-103	317.0	COG0369@1|root,COG1151@2|Bacteria,1NYH2@1224|Proteobacteria,42NE1@68525|delta/epsilon subdivisions,2WIVX@28221|Deltaproteobacteria,2MHKH@213118|Desulfobacterales	28221|Deltaproteobacteria	C	TIGRFAM carbon-monoxide dehydrogenase, catalytic subunit	-	-	1.2.7.4	ko:K00198	ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200	M00377	R07157,R08034	RC00250,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Prismane
k141_2720_1	243274.THEMA_07915	3.61e-76	238.0	COG4638@1|root,COG4638@2|Bacteria,2GCAJ@200918|Thermotogae	200918|Thermotogae	P	Rieske (2Fe-2S) domain	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
k141_1636_1	1541065.JRFE01000024_gene762	7.65e-63	208.0	COG0499@1|root,COG0499@2|Bacteria,1G1MN@1117|Cyanobacteria,3VJ51@52604|Pleurocapsales	1117|Cyanobacteria	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
k141_2822_1	469617.FUAG_02621	2.04e-42	155.0	COG0129@1|root,COG0129@2|Bacteria,378WV@32066|Fusobacteria	32066|Fusobacteria	H	Belongs to the IlvD Edd family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
k141_288_1	938709.AUSH02000022_gene1957	6.14e-06	51.6	COG2242@1|root,COG2242@2|Bacteria	2|Bacteria	H	protein methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
k141_113_1	130081.XP_005705034.1	7.87e-14	79.7	COG0085@1|root,KOG0214@2759|Eukaryota	2759|Eukaryota	K	DNA-directed 5'-3' RNA polymerase activity	rpoB	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009536,GO:0030880,GO:0032991,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03043,ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5,RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k141_1637_1	1511.CLOST_1604	2.25e-31	130.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,247JN@186801|Clostridia,25QYJ@186804|Peptostreptococcaceae	186801|Clostridia	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
k141_2538_1	497964.CfE428DRAFT_0179	4.84e-28	115.0	COG5421@1|root,COG5421@2|Bacteria,46U8B@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k141_564_1	1047013.AQSP01000113_gene746	1.55e-12	70.1	COG0558@1|root,COG0558@2|Bacteria,2NPRA@2323|unclassified Bacteria	2|Bacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA1	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf,DUF4833
k141_2455_1	72664.XP_006405918.1	3.75e-09	56.2	2DZEY@1|root,2S7E1@2759|Eukaryota,3805F@33090|Viridiplantae,3GPYC@35493|Streptophyta	72664.XP_006405918.1|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_2278_1	485916.Dtox_3926	6.39e-118	349.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1UQRR@1239|Firmicutes,24BSD@186801|Clostridia,2645U@186807|Peptococcaceae	186801|Clostridia	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
k141_289_1	1128421.JAGA01000002_gene1840	5.62e-21	98.6	COG2270@1|root,COG2270@2|Bacteria,2NP3G@2323|unclassified Bacteria	2|Bacteria	S	Vacuole effluxer Atg22 like	yxiO	-	-	ko:K06902	ko04138,map04138	-	-	-	ko00000,ko00001,ko02000,ko04131	2.A.1.24,9.A.15.1	-	-	ATG22,MFS_1
k141_1815_1	1121405.dsmv_0062	1.79e-20	92.0	COG1024@1|root,COG1024@2|Bacteria,1R61Y@1224|Proteobacteria,42P4M@68525|delta/epsilon subdivisions,2WJJU@28221|Deltaproteobacteria,2MIKD@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
k141_115_1	2880.D7FNC4	1.13e-21	86.7	2E4T1@1|root,2SBN4@2759|Eukaryota	2759|Eukaryota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_1473_1	1536772.R70723_06640	2.1e-54	185.0	COG5410@1|root,COG5410@2|Bacteria,1TSMG@1239|Firmicutes,4HBFH@91061|Bacilli,26WBM@186822|Paenibacillaceae	91061|Bacilli	S	Terminase-like family	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_6,Terminase_6C
k141_2008_1	1340434.AXVA01000008_gene3516	2.63e-06	54.7	COG0006@1|root,COG0006@2|Bacteria,1TQ44@1239|Firmicutes,4HAT7@91061|Bacilli,1ZMP5@1386|Bacillus	91061|Bacilli	E	Creatinase/Prolidase N-terminal domain	-	-	3.4.11.9,3.4.13.9	ko:K01262,ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
k141_290_1	1265505.ATUG01000001_gene3881	4.36e-87	278.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,42MJB@68525|delta/epsilon subdivisions,2WIXF@28221|Deltaproteobacteria,2MI9W@213118|Desulfobacterales	28221|Deltaproteobacteria	M	TIGRFAM penicillin-binding protein, 1A family	mrcA	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	iAF987.Gmet_0354	PCB_OB,Transgly,Transpeptidase
k141_1104_1	382464.ABSI01000005_gene1158	5.68e-77	243.0	COG2309@1|root,COG2309@2|Bacteria	2|Bacteria	E	aminopeptidase activity	pepS	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
k141_1379_1	429009.Adeg_1699	7.49e-28	114.0	COG0857@1|root,COG0857@2|Bacteria,1UEGG@1239|Firmicutes,25JDD@186801|Clostridia,42GQT@68295|Thermoanaerobacterales	186801|Clostridia	C	DRTGG domain	-	-	-	ko:K06873	-	-	-	-	ko00000	-	-	-	AAA_26,DRTGG
k141_2129_1	747365.Thena_1426	2.83e-46	173.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1TPTQ@1239|Firmicutes,249CX@186801|Clostridia,42FXS@68295|Thermoanaerobacterales	186801|Clostridia	C	TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,Acetyltransf_1,CoA_binding_2,Succ_CoA_lig
k141_1145_1	86416.Clopa_1685	1.89e-32	125.0	COG3935@1|root,COG3935@2|Bacteria,1VIV0@1239|Firmicutes,25CCE@186801|Clostridia	186801|Clostridia	L	DnaD domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_595_1	604354.TSIB_1965	6.29e-40	149.0	COG1042@1|root,arCOG01340@2157|Archaea,2XT9G@28890|Euryarchaeota,242W1@183968|Thermococci	183968|Thermococci	C	CoA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_2,Succ_CoA_lig
k141_881_1	666510.ASAC_1077	4.57e-48	172.0	COG1884@1|root,arCOG04232@2157|Archaea,2XPX0@28889|Crenarchaeota	28889|Crenarchaeota	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
k141_2748_1	10224.XP_006815925.1	1.79e-75	274.0	2CMP4@1|root,2QR56@2759|Eukaryota,39VQX@33154|Opisthokonta,3BR69@33208|Metazoa,3D755@33213|Bilateria	33208|Metazoa	S	Pao retrotransposon peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2,DUF1758,DUF1759,Peptidase_A17,Phlebovirus_G2,RVT_1,rve
k141_882_1	1485544.JQKP01000004_gene449	2.04e-39	150.0	COG0642@1|root,COG3290@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,COG3290@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	4HB_MCP_1,CHASE8,HAMP,HATPase_c,HisKA,Hpt,PAS_3,PAS_8,Response_reg
k141_1952_1	1167006.UWK_01125	2.83e-117	359.0	COG0427@1|root,COG0454@1|root,COG0427@2|Bacteria,COG0456@2|Bacteria,1MUGE@1224|Proteobacteria,42MHC@68525|delta/epsilon subdivisions,2WINZ@28221|Deltaproteobacteria,2MMNB@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Acetyl-CoA hydrolase/transferase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro,Acetyltransf_1
k141_2317_1	715451.ambt_21005	3.26e-07	50.8	COG0582@1|root,COG0582@2|Bacteria,1MU23@1224|Proteobacteria,1RMJ1@1236|Gammaproteobacteria,465SY@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Arm-DNA-bind_3,Phage_int_SAM_3,Phage_integrase
k141_2317_2	1235457.C404_11460	2.66e-16	75.1	COG2963@1|root,COG2963@2|Bacteria,1N2T5@1224|Proteobacteria,2WENN@28216|Betaproteobacteria,1KHYE@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Transposase	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k141_1220_1	1131266.ARWQ01000002_gene476	6.27e-75	243.0	COG0504@1|root,arCOG00063@2157|Archaea,41S7G@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
k141_2043_1	429009.Adeg_1784	9.42e-59	189.0	COG1894@1|root,COG1908@1|root,COG1894@2|Bacteria,COG1908@2|Bacteria,1V7I6@1239|Firmicutes,24JV2@186801|Clostridia,42GG4@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM methyl-viologen-reducing hydrogenase delta subunit	-	-	1.8.98.5,1.8.98.6	ko:K14127	ko00680,map00680	-	R00019,R11943,R11944	RC00011	ko00000,ko00001,ko01000	-	-	-	FlpD,NADH_4Fe-4S
k141_266_1	519989.ECTPHS_00755	1.2e-14	72.8	COG3177@1|root,COG3177@2|Bacteria,1MWAU@1224|Proteobacteria,1RRHZ@1236|Gammaproteobacteria,1WW8V@135613|Chromatiales	135613|Chromatiales	S	Fic/DOC family	-	-	-	-	-	-	-	-	-	-	-	-	Fic
k141_266_2	1123519.PSJM300_00395	4.28e-15	74.7	COG3654@1|root,COG3943@1|root,COG3654@2|Bacteria,COG3943@2|Bacteria,1MWKW@1224|Proteobacteria,1RPNB@1236|Gammaproteobacteria,1Z2I9@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	S	COG3943 Virulence protein	-	-	-	-	-	-	-	-	-	-	-	-	Fic,Virulence_RhuM
k141_268_1	415426.Hbut_1274	2.17e-88	290.0	COG0417@1|root,arCOG15272@2157|Archaea,2XPPT@28889|Crenarchaeota	28889|Crenarchaeota	L	SMART DNA-directed DNA polymerase B	dpo1	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B,DNA_pol_B_exo1
k141_2789_1	420324.KI911977_gene3204	9.99e-69	222.0	COG1861@1|root,COG1861@2|Bacteria,1QU5J@1224|Proteobacteria,2U0ZH@28211|Alphaproteobacteria,1JX2J@119045|Methylobacteriaceae	28211|Alphaproteobacteria	M	Transposase DDE domain group 1	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k141_741_1	573063.Metin_0058	9.18e-54	181.0	COG0206@1|root,arCOG02201@2157|Archaea,2XSV8@28890|Euryarchaeota,23QJU@183939|Methanococci	183939|Methanococci	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	-	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
k141_2280_1	1453505.JASY01000014_gene4398	5.94e-25	100.0	COG2050@1|root,COG2050@2|Bacteria,4NR0Z@976|Bacteroidetes,1I36N@117743|Flavobacteriia,2NWIV@237|Flavobacterium	976|Bacteroidetes	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
k141_2087_1	304371.MCP_1409	4.2e-78	246.0	COG0180@1|root,arCOG01887@2157|Archaea,2XSVC@28890|Euryarchaeota,2N997@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM aminoacyl-tRNA synthetase class Ib	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF692.Mbar_A1374	tRNA-synt_1b
k141_2627_1	247490.KSU1_C0728	3.89e-51	173.0	COG1194@1|root,COG1194@2|Bacteria,2IY33@203682|Planctomycetes	203682|Planctomycetes	L	COG1194 A G-specific DNA glycosylase	mutY	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD,NUDIX_4
k141_1189_1	1540257.JQMW01000011_gene2334	4.84e-109	325.0	COG1509@1|root,COG1509@2|Bacteria,1TQQZ@1239|Firmicutes,249JV@186801|Clostridia,36E9A@31979|Clostridiaceae	186801|Clostridia	E	lysine 2,3-aminomutase YodO family protein	ablA	-	5.4.3.2	ko:K01843	ko00310,map00310	-	R00461	RC00303	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,LAM_C,Radical_SAM
k141_1545_1	338963.Pcar_3052	1.13e-73	237.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,42N7X@68525|delta/epsilon subdivisions,2WMM9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k141_566_2	7029.ACYPI062965-PA	1.2e-20	92.8	KOG1075@1|root,KOG1075@2759|Eukaryota,3A278@33154|Opisthokonta,3BQC7@33208|Metazoa,3D3FI@33213|Bilateria,422CS@6656|Arthropoda,3SUI6@50557|Insecta,3ECF5@33342|Paraneoptera	33208|Metazoa	S	Endonuclease-reverse transcriptase	-	-	-	ko:K10443	-	-	-	-	ko00000,ko04121	-	-	-	Exo_endo_phos_2,RNase_H,RVT_1
k141_1008_1	744872.Spica_0371	3.41e-13	78.6	COG2211@1|root,COG2211@2|Bacteria,2J5PU@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k141_382_1	400682.PAC_15718800	3.87e-19	95.5	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa	33208|Metazoa	OU	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1,SCAN,rve,zf-CCHC,zf-H2C2
k141_1107_1	7029.ACYPI005628-PA	2.39e-07	57.8	COG0420@1|root,KOG2310@2759|Eukaryota,38FSW@33154|Opisthokonta,3BBFE@33208|Metazoa,3CTF9@33213|Bilateria,41X0E@6656|Arthropoda,3SIMW@50557|Insecta,3E932@33342|Paraneoptera	33208|Metazoa	L	Mre11 DNA-binding presumed domain	MRE11A	GO:0000003,GO:0000014,GO:0000018,GO:0000019,GO:0000075,GO:0000077,GO:0000228,GO:0000278,GO:0000280,GO:0000723,GO:0000724,GO:0000725,GO:0000726,GO:0000729,GO:0000781,GO:0000784,GO:0000785,GO:0000790,GO:0000793,GO:0000794,GO:0000819,GO:0001817,GO:0001819,GO:0001932,GO:0001934,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004527,GO:0004536,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006275,GO:0006278,GO:0006281,GO:0006302,GO:0006303,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007004,GO:0007049,GO:0007059,GO:0007062,GO:0007093,GO:0007095,GO:0007127,GO:0007129,GO:0007131,GO:0007275,GO:0007346,GO:0007507,GO:0008022,GO:0008150,GO:0008152,GO:0008156,GO:0008283,GO:0008408,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009893,GO:0009987,GO:0010389,GO:0010556,GO:0010558,GO:0010562,GO:0010564,GO:0010604,GO:0010605,GO:0010638,GO:0010833,GO:0010941,GO:0010948,GO:0010972,GO:0016043,GO:0016233,GO:0016604,GO:0016605,GO:0016787,GO:0016788,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019438,GO:0022402,GO:0022414,GO:0022616,GO:0030870,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031399,GO:0031401,GO:0031570,GO:0031572,GO:0031573,GO:0031860,GO:0031952,GO:0031954,GO:0031974,GO:0031981,GO:0032200,GO:0032204,GO:0032206,GO:0032268,GO:0032270,GO:0032392,GO:0032479,GO:0032481,GO:0032501,GO:0032502,GO:0032508,GO:0032875,GO:0032876,GO:0032991,GO:0033043,GO:0033044,GO:0033554,GO:0033674,GO:0034641,GO:0034645,GO:0034654,GO:0035825,GO:0035861,GO:0042325,GO:0042327,GO:0042592,GO:0042802,GO:0042981,GO:0043066,GO:0043067,GO:0043069,GO:0043085,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043549,GO:0043900,GO:0043901,GO:0043903,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044454,GO:0044464,GO:0044773,GO:0044774,GO:0044818,GO:0045132,GO:0045143,GO:0045786,GO:0045930,GO:0045934,GO:0045935,GO:0045937,GO:0046483,GO:0046596,GO:0046597,GO:0048285,GO:0048471,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048525,GO:0048731,GO:0048856,GO:0050789,GO:0050790,GO:0050792,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051054,GO:0051128,GO:0051130,GO:0051171,GO:0051172,GO:0051173,GO:0051174,GO:0051239,GO:0051240,GO:0051246,GO:0051247,GO:0051276,GO:0051321,GO:0051338,GO:0051347,GO:0051716,GO:0051726,GO:0060249,GO:0060255,GO:0060548,GO:0061982,GO:0065007,GO:0065008,GO:0065009,GO:0070013,GO:0070192,GO:0071103,GO:0071704,GO:0071840,GO:0071897,GO:0072359,GO:0080090,GO:0090304,GO:0090305,GO:0090329,GO:0090734,GO:0097159,GO:0098687,GO:0098813,GO:0140013,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1901987,GO:1901988,GO:1901990,GO:1901991,GO:1902749,GO:1902750,GO:1903046,GO:1903047,GO:1903900,GO:1903901,GO:2000104,GO:2000112,GO:2000113,GO:2001252	-	ko:K10865	ko03440,ko03450,ko04218,map03440,map03450,map04218	M00291,M00292,M00295	-	-	ko00000,ko00001,ko00002,ko03032,ko03400	-	-	-	Metallophos,Mre11_DNA_bind
k141_2282_1	1121957.ATVL01000008_gene4558	4.64e-32	122.0	COG0538@1|root,COG0538@2|Bacteria,4PKW6@976|Bacteroidetes,47NMD@768503|Cytophagia	976|Bacteroidetes	C	Isocitrate/isopropylmalate dehydrogenase	icd	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
k141_840_1	67593.Physo108986	4.47e-111	331.0	COG5277@1|root,KOG0676@2759|Eukaryota,3QEGK@4776|Peronosporales	4776|Peronosporales	Z	Belongs to the actin family	-	-	-	ko:K05692	ko04015,ko04145,ko04210,ko04390,ko04391,ko04510,ko04520,ko04530,ko04611,ko04670,ko04714,ko04745,ko04810,ko04919,ko04921,ko05100,ko05110,ko05130,ko05131,ko05132,ko05164,ko05205,ko05225,ko05410,ko05412,ko05414,ko05416,ko05418,map04015,map04145,map04210,map04390,map04391,map04510,map04520,map04530,map04611,map04670,map04714,map04745,map04810,map04919,map04921,map05100,map05110,map05130,map05131,map05132,map05164,map05205,map05225,map05410,map05412,map05414,map05416,map05418	-	-	-	ko00000,ko00001,ko03019,ko03021,ko03029,ko03036,ko04147,ko04812	-	-	-	Actin
k141_469_1	653733.Selin_2379	1.75e-99	296.0	COG4974@1|root,COG4974@2|Bacteria	2|Bacteria	L	Belongs to the 'phage' integrase family	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_4,Phage_integrase
k141_1732_1	653948.CCA22573	8.91e-32	126.0	COG0019@1|root,KOG0622@2759|Eukaryota	2759|Eukaryota	E	putrescine biosynthetic process from ornithine	-	-	3.6.4.13,4.1.1.20,4.1.1.50	ko:K01586,ko:K01611,ko:K18408	ko00270,ko00300,ko00330,ko01100,ko01110,ko01120,ko01130,ko01230,map00270,map00300,map00330,map01100,map01110,map01120,map01130,map01230	M00016,M00034,M00133,M00525,M00526,M00527	R00178,R00451	RC00299	ko00000,ko00001,ko00002,ko01000,ko03036	-	-	iG2583_1286.G2583_3495	AA_kinase,Orn_Arg_deC_N,Orn_DAP_Arg_deC
k141_1380_1	335543.Sfum_3070	1.31e-63	217.0	COG0427@1|root,COG1670@1|root,COG0427@2|Bacteria,COG1670@2|Bacteria,1MUGE@1224|Proteobacteria,42MHC@68525|delta/epsilon subdivisions,2WINZ@28221|Deltaproteobacteria,2MR2F@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	acetyl-CoA	-	-	-	ko:K18122,ko:K18288	ko00650,ko00660,ko01100,ko01200,map00650,map00660,map01100,map01200	-	R02407,R05336,R10600	RC00012,RC00014	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_2142,iAF987.Gmet_3304	AcetylCoA_hyd_C,AcetylCoA_hydro,Acetyltransf_1,Acetyltransf_3
k141_841_1	71139.XP_010039663.1	1.17e-07	52.0	KOG4853@1|root,KOG4853@2759|Eukaryota,37VMJ@33090|Viridiplantae,3GJ4H@35493|Streptophyta	35493|Streptophyta	S	mitotic sister chromatid biorientation	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_386_2	880073.Calab_3048	1.09e-17	82.0	COG1150@1|root,COG1150@2|Bacteria,2NQ2K@2323|unclassified Bacteria	2|Bacteria	C	4Fe-4S dicluster domain	hdrC	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389,ko:K03390,ko:K16887,ko:K18930	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_3424	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17,Fer4_7,Fer4_8,Fer4_9
k141_1010_1	1038860.AXAP01000062_gene2430	8.08e-07	56.2	COG2433@1|root,COG2433@2|Bacteria,1RJ1Q@1224|Proteobacteria,2U9U2@28211|Alphaproteobacteria,3K6N1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	IS66 C-terminal element	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
k141_2723_2	511437.Lbuc_1535	6.2e-12	66.2	2EGZP@1|root,33ART@2|Bacteria,1VKPB@1239|Firmicutes,4HR69@91061|Bacilli,3F8RA@33958|Lactobacillaceae	91061|Bacilli	S	YopX protein	-	-	-	-	-	-	-	-	-	-	-	-	YopX
k141_471_1	1304880.JAGB01000002_gene1980	2.53e-79	247.0	COG0473@1|root,COG0473@2|Bacteria,1TPEM@1239|Firmicutes,24A63@186801|Clostridia	186801|Clostridia	C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	-	-	1.1.1.41	ko:K00030	ko00020,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010	R00709	RC00114	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
k141_1190_1	398527.Bphyt_0041	1.02e-23	107.0	COG0154@1|root,COG0154@2|Bacteria,1MW3Z@1224|Proteobacteria,2VKAQ@28216|Betaproteobacteria,1KFGH@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Belongs to the amidase family	-	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
k141_743_1	583355.Caka_0770	9.72e-66	214.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1,Glycos_transf_2
k141_200_1	28152.DJ57_2550	2.91e-38	151.0	28JKJ@1|root,2Z9DD@2|Bacteria,1MUN2@1224|Proteobacteria,1RQIP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Phage P22-like portal protein	-	-	-	-	-	-	-	-	-	-	-	-	P22_portal
k141_2827_1	596154.Alide2_3409	1.79e-49	170.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1MW7X@1224|Proteobacteria,2VMDX@28216|Betaproteobacteria,4AAP5@80864|Comamonadaceae	28216|Betaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	ko:K07494	-	-	-	-	ko00000	-	-	-	DDE_3,HTH_23,HTH_29,HTH_32
k141_2012_1	1232410.KI421415_gene3030	2.34e-27	114.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,42N8Y@68525|delta/epsilon subdivisions,2WIR7@28221|Deltaproteobacteria,43SUM@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	pyridine nucleotide-disulphide oxidoreductase dimerisation region	lpdA-2	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim,SNARE_assoc
k141_1474_1	335543.Sfum_3236	2.91e-26	112.0	COG2203@1|root,COG3437@1|root,COG2203@2|Bacteria,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,42T7G@68525|delta/epsilon subdivisions,2WKC5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	metal-dependent phosphohydrolase HD	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GGDEF,HD,HD_5,dCache_2
k141_1546_1	98439.AJLL01000097_gene2023	2.17e-22	101.0	COG0642@1|root,COG0745@1|root,COG2114@1|root,COG2203@1|root,COG3437@1|root,COG0745@2|Bacteria,COG2114@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG3437@2|Bacteria,1G0F6@1117|Cyanobacteria	1117|Cyanobacteria	T	PFAM Adenylate and Guanylate cyclase catalytic domain	cyaC	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	GAF,Guanylate_cyc,HATPase_c,HisKA,Response_reg
k141_1818_1	647113.Metok_1064	1.07e-35	135.0	COG1163@1|root,arCOG00358@2157|Archaea,2XTYK@28890|Euryarchaeota,23QKG@183939|Methanococci	183939|Methanococci	S	TIGRFAM Small GTP-binding protein	-	-	-	ko:K06944	-	-	-	-	ko00000	-	-	-	MMR_HSR1,MMR_HSR1_Xtn,TGS
k141_292_1	269482.Bcep1808_1635	1.87e-73	231.0	COG1878@1|root,COG1878@2|Bacteria,1MV8S@1224|Proteobacteria,2VNYM@28216|Betaproteobacteria,1KBVW@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
k141_1283_2	1220534.B655_1871	1.79e-29	117.0	COG1690@1|root,arCOG04246@2157|Archaea,2XTIC@28890|Euryarchaeota,23NQ3@183925|Methanobacteria	183925|Methanobacteria	S	Belongs to the RtcB family	rtcB	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
k141_570_1	604354.TSIB_0527	1.19e-33	128.0	COG1405@1|root,arCOG01981@2157|Archaea,2XT0Z@28890|Euryarchaeota,242MH@183968|Thermococci	183968|Thermococci	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfb	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
k141_1819_1	411490.ANACAC_03559	7.72e-07	53.1	COG2239@1|root,COG2239@2|Bacteria,1TP4V@1239|Firmicutes,2481R@186801|Clostridia	186801|Clostridia	P	Acts as a magnesium transporter	mgtE	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
k141_119_1	1123371.ATXH01000003_gene1954	2.11e-42	151.0	COG0226@1|root,COG0226@2|Bacteria,2GGVR@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	P	PBP superfamily domain	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
k141_2828_1	656519.Halsa_1019	7.88e-49	172.0	COG1070@1|root,COG1070@2|Bacteria,1TQ1I@1239|Firmicutes,247NR@186801|Clostridia	186801|Clostridia	G	Psort location Cytoplasmic, score 8.87	-	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
k141_1192_1	1129374.AJE_02771	5.43e-11	67.4	COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,1RN5G@1236|Gammaproteobacteria,464XH@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	COG0714 MoxR-like ATPases	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
k141_2092_1	159749.K0SXC9	1.24e-63	222.0	29N4Q@1|root,2RVF7@2759|Eukaryota,2XBJX@2836|Bacillariophyta	159749.K0SXC9|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_483_1	1056495.Calag_1118	3.56e-23	92.4	COG0023@1|root,arCOG04223@2157|Archaea,2XQSE@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the SUI1 family	-	GO:0001731,GO:0002181,GO:0002183,GO:0002188,GO:0002190,GO:0002192,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0065003,GO:0070992,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0110017,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K03113	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	SUI1
k141_483_2	453591.Igni_1407	1.33e-15	73.2	COG0186@1|root,arCOG04096@2157|Archaea,2XQZ6@28889|Crenarchaeota	28889|Crenarchaeota	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rps17	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
k141_1826_2	525897.Dbac_0930	1.62e-08	54.7	COG2145@1|root,COG2145@2|Bacteria,1MVES@1224|Proteobacteria,42PAR@68525|delta/epsilon subdivisions,2WMWU@28221|Deltaproteobacteria,2M9XR@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)	thiM	-	2.7.1.50	ko:K00878	ko00730,ko01100,map00730,map01100	M00127	R04448	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HK
k141_2022_1	304371.MCP_1264	1.85e-165	492.0	COG0474@1|root,arCOG01578@2157|Archaea,2XT4B@28890|Euryarchaeota,2N91H@224756|Methanomicrobia	224756|Methanomicrobia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.6	ko:K01535	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.3.3	-	-	Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k141_1019_1	1121405.dsmv_3248	1.9e-37	134.0	28PNF@1|root,2ZCB7@2|Bacteria,1RA6N@1224|Proteobacteria,42RBI@68525|delta/epsilon subdivisions,2WN4P@28221|Deltaproteobacteria,2MJHU@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_1390_2	3712.Bo00613s140.1	1.15e-06	49.7	2E4T1@1|root,2SBN4@2759|Eukaryota	2759|Eukaryota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_1390_3	9544.ENSMMUP00000041385	3.78e-19	79.3	2EA4H@1|root,2SGDU@2759|Eukaryota,3A53V@33154|Opisthokonta,3BVUU@33208|Metazoa,3D7Z1@33213|Bilateria	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_1744_1	1336234.JAGN01000042_gene485	4.28e-53	193.0	COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,4HAW9@91061|Bacilli,27F9T@186828|Carnobacteriaceae	91061|Bacilli	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k141_2194_1	56780.SYN_02657	1.14e-41	148.0	COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,42TG6@68525|delta/epsilon subdivisions,2WQ8T@28221|Deltaproteobacteria,2MRYG@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	Transposase domain (DUF772)	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
k141_397_1	1408418.JNJH01000075_gene221	9.44e-96	307.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2TRZD@28211|Alphaproteobacteria,2JV23@204441|Rhodospirillales	204441|Rhodospirillales	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.6	ko:K01535	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.3.3	-	-	Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k141_1651_1	374847.Kcr_0948	2.7e-53	187.0	COG3808@1|root,arCOG04949@2157|Archaea	2157|Archaea	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
k141_756_1	523845.AQXV01000052_gene565	1.54e-83	268.0	COG0464@1|root,arCOG01308@2157|Archaea,2XSYR@28890|Euryarchaeota,23QF3@183939|Methanococci	183939|Methanococci	O	Cell division protein 48, CDC48, domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N,Vps4_C
k141_1391_2	368408.Tpen_1372	1.12e-27	114.0	COG0277@1|root,arCOG00337@2157|Archaea,2XQ8R@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM FAD linked oxidase domain protein	-	-	2.5.1.26	ko:K00803	ko00565,ko01100,ko04146,map00565,map01100,map04146	-	R04311	RC00020,RC02886	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
k141_301_1	158189.SpiBuddy_0310	4.67e-75	243.0	COG1233@1|root,COG1233@2|Bacteria	2|Bacteria	Q	all-trans-retinol 13,14-reductase activity	-	-	1.3.99.23,5.2.1.13	ko:K09516,ko:K09835	ko00830,ko00906,ko01100,ko01110,map00830,map00906,map01100,map01110	M00097	R07163,R07512	RC01835,RC01960	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase,NAD_binding_8
k141_1652_1	30611.ENSOGAP00000016148	1.46e-15	77.8	COG1100@1|root,KOG0070@2759|Eukaryota,39UXZ@33154|Opisthokonta,3BKJ8@33208|Metazoa,3D0Z3@33213|Bilateria,48658@7711|Chordata,492VS@7742|Vertebrata,3J6RC@40674|Mammalia,35ERP@314146|Euarchontoglires,4MID5@9443|Primates	33208|Metazoa	U	Belongs to the small GTPase superfamily. Arf family	ARL14	-	-	ko:K17200	-	-	-	-	ko00000,ko04031	-	-	-	Arf
k141_577_1	1246626.BleG1_1323	1.33e-14	77.0	COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,4HCH3@91061|Bacilli,1ZAXG@1386|Bacillus	91061|Bacilli	I	Belongs to the enoyl-CoA hydratase isomerase family	yngF	GO:0003674,GO:0003824,GO:0004300,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575	-	-	-	-	-	-	-	-	-	-	ECH_1
k141_1020_1	273121.WS1957	7.46e-102	306.0	COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,1MVC8@1224|Proteobacteria,42NJR@68525|delta/epsilon subdivisions,2YTAR@29547|Epsilonproteobacteria	68525|delta/epsilon subdivisions	L	HTH-like domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,HTH_Tnp_1,rve,rve_3
k141_2289_1	269797.Mbar_A1337	2.92e-31	124.0	COG0433@1|root,arCOG00284@2157|Archaea,2Y7NC@28890|Euryarchaeota,2NBKJ@224756|Methanomicrobia	224756|Methanomicrobia	L	AAA-like domain	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87
k141_1201_1	984892.SPSE_1756	8.91e-43	155.0	COG0677@1|root,COG0677@2|Bacteria,1TPXY@1239|Firmicutes,4HAFY@91061|Bacilli,4GYD5@90964|Staphylococcaceae	91061|Bacilli	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	capO	-	1.1.1.336	ko:K02472	ko00520,ko05111,map00520,map05111	-	R03317	RC00291	ko00000,ko00001,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
k141_2104_1	7222.FBpp0145925	2.16e-18	89.0	KOG0084@1|root,KOG0084@2759|Eukaryota,38DXZ@33154|Opisthokonta,3BEKS@33208|Metazoa,3CWWC@33213|Bilateria,41WJ7@6656|Arthropoda,3SHCS@50557|Insecta,450Y9@7147|Diptera,45Y66@7214|Drosophilidae	33208|Metazoa	U	GTP binding. It is involved in the biological process described with protein transport	-	GO:0003674,GO:0003824,GO:0003924,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005768,GO:0005886,GO:0006810,GO:0007154,GO:0007165,GO:0007264,GO:0007265,GO:0008150,GO:0009987,GO:0010008,GO:0012505,GO:0016020,GO:0016192,GO:0016197,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0023052,GO:0031090,GO:0031410,GO:0031982,GO:0032456,GO:0032482,GO:0035556,GO:0043226,GO:0043227,GO:0043229,GO:0044422,GO:0044424,GO:0044433,GO:0044440,GO:0044444,GO:0044446,GO:0044464,GO:0046907,GO:0050789,GO:0050794,GO:0050896,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0051716,GO:0065007,GO:0071944,GO:0097708,GO:0098588,GO:0098805	-	ko:K07874	ko05134,map05134	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
k141_671_1	159749.K0TQC7	8.08e-33	132.0	COG2801@1|root,KOG0017@2759|Eukaryota,2XF4I@2836|Bacillariophyta	159749.K0TQC7|-	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_1392_1	545695.TREAZ_0999	9.1e-49	175.0	COG1486@1|root,COG1486@2|Bacteria,2J6Z5@203691|Spirochaetes	203691|Spirochaetes	G	Family 4 glycosyl hydrolase	-	-	3.2.1.22	ko:K07406	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_4,Glyco_hydro_4C
k141_2643_1	487521.OCU_06970	8.19e-16	82.8	2EP1Y@1|root,33GNT@2|Bacteria,2IC2I@201174|Actinobacteria,2380S@1762|Mycobacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_2552_1	997884.HMPREF1068_03239	4.9e-34	132.0	COG2195@1|root,COG2195@2|Bacteria,4NG8I@976|Bacteroidetes,2FNVV@200643|Bacteroidia,4AM0Y@815|Bacteroidaceae	976|Bacteroidetes	E	Psort location Cytoplasmic, score 8.96	pepD_1	-	-	ko:K01270	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
k141_1927_1	485915.Dret_2002	2.46e-134	394.0	COG3464@1|root,COG3464@2|Bacteria,1R4DH@1224|Proteobacteria,43AQ4@68525|delta/epsilon subdivisions,2X63W@28221|Deltaproteobacteria,2MGXP@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	PFAM transposase IS204 IS1001 IS1096 IS1165 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,zf-ISL3
k141_759_1	1121406.JAEX01000013_gene1235	2.14e-90	275.0	COG1162@1|root,COG1162@2|Bacteria,1MUEF@1224|Proteobacteria,42MQV@68525|delta/epsilon subdivisions,2WIZC@28221|Deltaproteobacteria,2MA57@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase
k141_2106_1	102129.Lepto7375DRAFT_0118	3.86e-19	89.4	COG3039@1|root,COG3039@2|Bacteria,1G3IA@1117|Cyanobacteria,1HEFE@1150|Oscillatoriales	1117|Cyanobacteria	L	Transposase domain (DUF772)	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k141_856_1	2754.EH55_04585	9.83e-06	53.1	COG3875@1|root,COG3875@2|Bacteria	2|Bacteria	S	lactate racemase activity	-	-	5.1.2.1	ko:K22373	ko00620,map00620	-	R01450	RC00519	ko00000,ko00001,ko01000	-	-	-	DUF2088
k141_760_1	865861.AZSU01000001_gene503	1.4e-76	246.0	COG0129@1|root,COG0129@2|Bacteria,1TP1R@1239|Firmicutes,247UC@186801|Clostridia,36DS1@31979|Clostridiaceae	186801|Clostridia	EG	Belongs to the IlvD Edd family	-	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
k141_2645_1	694429.Pyrfu_0204	2.58e-36	131.0	COG0638@1|root,arCOG00970@2157|Archaea,2XQG7@28889|Crenarchaeota	28889|Crenarchaeota	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmB1	-	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
k141_929_1	1416760.AYMS01000092_gene621	1.23e-91	281.0	COG3385@1|root,COG3385@2|Bacteria,4NJC6@976|Bacteroidetes,1I3BQ@117743|Flavobacteriia,47ITJ@76831|Myroides	976|Bacteroidetes	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4372
k141_2371_1	1285586.H131_12768	2.94e-10	67.8	COG0477@1|root,COG0477@2|Bacteria,1TQVH@1239|Firmicutes,4HBBN@91061|Bacilli,3J022@400634|Lysinibacillus	91061|Bacilli	EGP	Transmembrane secretion effector	mefE	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k141_303_1	521045.Kole_1307	2.16e-13	71.6	COG2856@1|root,COG3093@1|root,COG2856@2|Bacteria,COG3093@2|Bacteria	2|Bacteria	K	addiction module antidote protein HigA	higA	-	-	ko:K18831,ko:K21498	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	HTH_3,Peptidase_M78
k141_303_2	639282.DEFDS_0716	1.65e-16	75.1	COG3549@1|root,COG3549@2|Bacteria,2GG29@200930|Deferribacteres	200930|Deferribacteres	S	RelE-like toxin of type II toxin-antitoxin system HigB	-	-	-	ko:K07334	-	-	-	-	ko00000,ko02048	-	-	-	HigB-like_toxin
k141_2372_1	37659.JNLN01000001_gene936	8.13e-61	199.0	2C3VR@1|root,2Z9AE@2|Bacteria,1UZNB@1239|Firmicutes,24D9F@186801|Clostridia,36FQA@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_2291_1	158189.SpiBuddy_2081	2.52e-13	76.3	COG2211@1|root,COG2211@2|Bacteria,2JAUS@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Major Facilitator Superfamily	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
k141_1831_1	592026.GCWU0000282_002679	6.46e-89	276.0	COG4030@1|root,COG4030@2|Bacteria,1UZEG@1239|Firmicutes,24DRT@186801|Clostridia	186801|Clostridia	S	Protein of unknown function (DUF2961)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2961
k141_858_1	192952.MM_0233	1.54e-61	201.0	COG0013@1|root,arCOG01254@2157|Archaea,2XTZC@28890|Euryarchaeota,2NBIC@224756|Methanomicrobia	224756|Methanomicrobia	J	Functions in trans to edit the amino acid moiety from	alaXM	GO:0002161,GO:0003674,GO:0003824,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360	-	ko:K07050	-	-	-	-	ko00000,ko01000,ko03016	-	-	iAF692.Mbar_A2092	tRNA-synt_2c,tRNA_SAD
k141_399_1	1122611.KB903954_gene5673	1.8e-27	121.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,2GMN4@201174|Actinobacteria,4EFTG@85012|Streptosporangiales	201174|Actinobacteria	GT	PEP-utilising enzyme, mobile domain	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
k141_1832_1	933262.AXAM01000165_gene3165	1.11e-95	283.0	COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,42SSD@68525|delta/epsilon subdivisions,2WPWR@28221|Deltaproteobacteria,2MK6M@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Putative transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
k141_165_1	257310.BB0578	2.19e-63	210.0	COG0183@1|root,COG0183@2|Bacteria,1RGC4@1224|Proteobacteria,2W2T1@28216|Betaproteobacteria	28216|Betaproteobacteria	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	-
k141_1270_2	1122605.KB893643_gene656	4.8e-09	59.7	2EGZP@1|root,33ART@2|Bacteria	2|Bacteria	S	YopX protein	-	-	-	-	-	-	-	-	-	-	-	-	YopX
k141_1093_1	386456.JQKN01000001_gene1762	7.44e-11	64.7	COG0469@1|root,arCOG04071@2157|Archaea,2XTXX@28890|Euryarchaeota,23NJ7@183925|Methanobacteria	183925|Methanobacteria	J	50S ribosomal protein L4	rpl4	-	-	ko:K02930	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
k141_1093_2	70601.3258209	3.35e-10	57.4	COG0089@1|root,arCOG04072@2157|Archaea,2XYPG@28890|Euryarchaeota,244AA@183968|Thermococci	183968|Thermococci	J	Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome	rpl23	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
k141_1806_1	497964.CfE428DRAFT_0179	3.32e-84	270.0	COG5421@1|root,COG5421@2|Bacteria,46U8B@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k141_1458_1	933262.AXAM01000052_gene2011	4.7e-43	143.0	COG0099@1|root,COG0099@2|Bacteria,1RD1G@1224|Proteobacteria,42RE3@68525|delta/epsilon subdivisions,2WPD5@28221|Deltaproteobacteria,2MK1T@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
k141_647_1	1410653.JHVC01000005_gene2582	2.13e-44	151.0	COG0454@1|root,COG0456@2|Bacteria,1V562@1239|Firmicutes,24G6G@186801|Clostridia,36HZD@31979|Clostridiaceae	186801|Clostridia	K	Acetyltransferase (GNAT) domain	-	GO:0003674,GO:0003824,GO:0016740,GO:0016746,GO:0016747	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k141_459_1	1121405.dsmv_2651	8.13e-48	169.0	COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,42QDV@68525|delta/epsilon subdivisions,2WIRQ@28221|Deltaproteobacteria,2MN1S@213118|Desulfobacterales	68525|delta/epsilon subdivisions	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k141_825_1	309800.C498_18853	4.17e-28	116.0	COG0541@1|root,arCOG01228@2157|Archaea,2XTWX@28890|Euryarchaeota,23T57@183963|Halobacteria	183963|Halobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	srp54	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
k141_2804_1	521674.Plim_3539	6.19e-15	80.1	COG0553@1|root,COG0553@2|Bacteria,2IX46@203682|Planctomycetes	203682|Planctomycetes	KL	helicase superfamily c-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N,SWIM
k141_103_1	3712.Bo9g161880.1	1.02e-54	193.0	COG0525@1|root,KOG1422@1|root,KOG0432@2759|Eukaryota,KOG1422@2759|Eukaryota,37QE7@33090|Viridiplantae,3GBVU@35493|Streptophyta,3HP0S@3699|Brassicales	35493|Streptophyta	J	Belongs to the class-I aminoacyl-tRNA synthetase family	-	GO:0000003,GO:0003006,GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0007275,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009790,GO:0009791,GO:0009793,GO:0009987,GO:0010154,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0022414,GO:0032501,GO:0032502,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0048316,GO:0048608,GO:0048731,GO:0048856,GO:0061458,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
k141_730_1	458817.Shal_0863	1e-05	51.2	COG1522@1|root,COG1522@2|Bacteria,1RDB3@1224|Proteobacteria,1S2E1@1236|Gammaproteobacteria,2QC3V@267890|Shewanellaceae	1236|Gammaproteobacteria	K	PFAM regulatory protein AsnC Lrp family	ybaO	GO:0000096,GO:0000098,GO:0001101,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006351,GO:0006355,GO:0006520,GO:0006534,GO:0006725,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009059,GO:0009063,GO:0009069,GO:0009071,GO:0009093,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010033,GO:0010243,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016054,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019752,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0043170,GO:0043200,GO:0043254,GO:0043436,GO:0043565,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044271,GO:0044273,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046395,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901698,GO:1901700,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2000142,GO:2000144,GO:2001141	-	ko:K05800	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
k141_1000_1	1114856.C496_09266	6.93e-25	105.0	COG1266@1|root,arCOG02768@2157|Archaea,2XZ3X@28890|Euryarchaeota,23WZT@183963|Halobacteria	183963|Halobacteria	S	metal-dependent membrane protease	-	-	-	-	-	-	-	-	-	-	-	-	Abi
k141_2711_1	224325.AF_2421	5.95e-104	335.0	COG0495@1|root,arCOG00809@2157|Archaea,2XU7M@28890|Euryarchaeota,245T8@183980|Archaeoglobi	183980|Archaeoglobi	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1
k141_372_1	1121091.AUMP01000003_gene2597	2.19e-45	181.0	COG0503@1|root,COG0503@2|Bacteria,1TSYQ@1239|Firmicutes,4HTNY@91061|Bacilli	91061|Bacilli	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_2805_1	1122990.BAJH01000003_gene584	1.49e-59	204.0	COG1148@1|root,COG1148@2|Bacteria,4NI95@976|Bacteroidetes,2FRRV@200643|Bacteroidia	976|Bacteroidetes	C	NAD(P)-binding Rossmann-like domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Fer4,Fer4_7,HI0933_like,Pyr_redox_2
k141_2445_1	1444712.BN1013_00060	9.02e-45	161.0	COG0399@1|root,COG0399@2|Bacteria,2JFE1@204428|Chlamydiae	204428|Chlamydiae	E	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	1.17.1.1,2.6.1.98	ko:K12452,ko:K13017	ko00520,map00520	-	R03391,R03392,R10141	RC00006,RC00230,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	DegT_DnrJ_EryC1
k141_2531_1	868131.MSWAN_0163	8.67e-17	82.4	COG0382@1|root,arCOG00476@2157|Archaea,2XVE4@28890|Euryarchaeota	28890|Euryarchaeota	H	COG0382 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	UbiA
k141_1094_1	97139.C824_04890	2.16e-72	221.0	COG1943@1|root,COG1943@2|Bacteria,1V53Y@1239|Firmicutes,25CMQ@186801|Clostridia,36VU7@31979|Clostridiaceae	186801|Clostridia	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
k141_1180_1	653045.Strvi_4523	2.02e-94	293.0	COG3119@1|root,COG3119@2|Bacteria,2H50Z@201174|Actinobacteria	201174|Actinobacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
k141_1631_1	415426.Hbut_1625	6.86e-51	185.0	COG4231@1|root,arCOG01609@2157|Archaea,2XPN3@28889|Crenarchaeota	28889|Crenarchaeota	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,POR_N,TPP_enzyme_C
k141_1902_1	1449357.JQLK01000005_gene2449	1.14e-52	178.0	COG2801@1|root,COG2801@2|Bacteria,1WIE5@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	L	PFAM Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,rve_3
k141_2267_1	1123277.KB893200_gene6374	2.11e-48	159.0	COG3415@1|root,COG3415@2|Bacteria,4NSMH@976|Bacteroidetes,47REK@768503|Cytophagia	976|Bacteroidetes	L	Homeodomain-like domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32
k141_1459_1	10224.XP_006825930.1	1.15e-29	125.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria	33208|Metazoa	G	positive regulation of TOR signaling	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k141_2806_1	1094980.Mpsy_3165	1.14e-13	78.6	COG0433@1|root,arCOG03732@1|root,arCOG00280@2157|Archaea,arCOG03732@2157|Archaea,2Y7MA@28890|Euryarchaeota,2NA8T@224756|Methanomicrobia	224756|Methanomicrobia	L	AAA-like domain	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87,HAS-barrel
k141_373_1	1408226.T233_00129	6.07e-05	47.0	COG1918@1|root,COG1918@2|Bacteria,1VEHC@1239|Firmicutes,4HPFS@91061|Bacilli,4B083@81852|Enterococcaceae	91061|Bacilli	P	FeoA	feoA	-	-	ko:K04758	-	-	-	-	ko00000,ko02000	-	-	-	FeoA
k141_373_2	1200557.JHWV01000001_gene372	4.51e-20	90.5	COG0370@1|root,COG0370@2|Bacteria,1TP7E@1239|Firmicutes,4H26E@909932|Negativicutes	909932|Negativicutes	P	transporter of a GTP-driven Fe(2 ) uptake system	feoB	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
k141_17_1	1304885.AUEY01000108_gene2931	4.04e-18	83.6	COG3276@1|root,COG3276@2|Bacteria,1MWXH@1224|Proteobacteria,42M49@68525|delta/epsilon subdivisions,2WJ5G@28221|Deltaproteobacteria,2MIIX@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Elongation factor SelB winged helix	selB	-	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3
k141_1181_2	933262.AXAM01000017_gene3146	3.8e-30	107.0	COG1148@1|root,COG1148@2|Bacteria,1NA53@1224|Proteobacteria,42V92@68525|delta/epsilon subdivisions,2WS6E@28221|Deltaproteobacteria,2MM0X@213118|Desulfobacterales	28221|Deltaproteobacteria	C	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_8,Pyr_redox_2
k141_105_1	5911.EAR91266	0.000331	48.5	KOG0084@1|root,KOG0084@2759|Eukaryota,3ZBKW@5878|Ciliophora	5878|Ciliophora	U	Rab subfamily of small GTPases	-	-	-	ko:K07874	ko05134,map05134	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
k141_1095_1	1173028.ANKO01000006_gene2088	5.59e-27	114.0	COG4992@1|root,COG4992@2|Bacteria,1G0KF@1117|Cyanobacteria,1H91B@1150|Oscillatoriales	1117|Cyanobacteria	E	TIGRFAM acetylornithine and succinylornithine transaminases	argD	GO:0003674,GO:0005488,GO:0005515,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k141_2447_1	1227487.C474_00742	5.8e-12	65.9	COG1690@1|root,arCOG04246@2157|Archaea,2XTIC@28890|Euryarchaeota,23T1D@183963|Halobacteria	183963|Halobacteria	L	Belongs to the RtcB family	rtcB	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Intein_splicing,RtcB
k141_374_1	224719.Abm4_0877	1.45e-38	147.0	COG1205@1|root,arCOG03042@1|root,arCOG00555@2157|Archaea,arCOG03042@2157|Archaea,2XTPR@28890|Euryarchaeota,23PD4@183925|Methanobacteria	183925|Methanobacteria	L	Domain of unknown function (DUF1998)	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
k141_1461_1	933262.AXAM01000052_gene1988	3.42e-99	297.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,42MWZ@68525|delta/epsilon subdivisions,2WJ2B@28221|Deltaproteobacteria,2MHTQ@213118|Desulfobacterales	28221|Deltaproteobacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
k141_1725_1	644968.DFW101_2946	3.87e-66	221.0	COG4584@1|root,COG4584@2|Bacteria,1MU2G@1224|Proteobacteria,42P15@68525|delta/epsilon subdivisions,2WK8D@28221|Deltaproteobacteria,2MASN@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	HTH_7,rve
k141_283_1	42099.EPrPV00000016524	2.4e-34	136.0	COG0474@1|root,COG0571@1|root,KOG0202@2759|Eukaryota,KOG0701@2759|Eukaryota,1MDQI@121069|Pythiales	121069|Pythiales	P	Calcium-transporting ATPase 1, endoplasmic reticulum-type. Source PGD	-	-	-	-	-	-	-	-	-	-	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
k141_375_1	159749.K0TP24	5.29e-59	207.0	COG2801@1|root,2QT1S@2759|Eukaryota	2759|Eukaryota	L	transposition	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1,rve
k141_2176_1	633148.Tagg_1400	3.72e-45	154.0	COG0049@1|root,arCOG04254@2157|Archaea,2XPUU@28889|Crenarchaeota	28889|Crenarchaeota	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center	rps7	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
k141_733_1	56780.SYN_00790	1.85e-79	249.0	COG3039@1|root,COG3039@2|Bacteria,1MVTU@1224|Proteobacteria,42Q03@68525|delta/epsilon subdivisions,2WMFQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Transposase domain (DUF772)	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k141_1292_2	398767.Glov_3450	4.91e-217	607.0	COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,42S30@68525|delta/epsilon subdivisions,2WQ5S@28221|Deltaproteobacteria,43VCE@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	PFAM transposase mutator type	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k141_1653_1	579137.Metvu_0248	1.72e-06	55.1	COG0644@1|root,arCOG00570@2157|Archaea,2XUI9@28890|Euryarchaeota,23QKR@183939|Methanococci	183939|Methanococci	C	TIGRFAM geranylgeranyl reductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
k141_930_1	1184251.TCELL_0522	1.41e-60	190.0	COG0048@1|root,arCOG04255@2157|Archaea,2XQ79@28889|Crenarchaeota	28889|Crenarchaeota	J	With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits	rps12	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
k141_1654_1	316067.Geob_2332	6.44e-20	90.5	COG4191@1|root,COG4564@1|root,COG4191@2|Bacteria,COG4564@2|Bacteria,1R5Q1@1224|Proteobacteria,42RPW@68525|delta/epsilon subdivisions,2WK10@28221|Deltaproteobacteria,43UCM@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Cache domain	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,dCache_2
k141_2160_2	439235.Dalk_4561	2.51e-12	70.1	COG5525@1|root,COG5525@2|Bacteria,1NE5I@1224|Proteobacteria	1224|Proteobacteria	S	Phage terminase large subunit (GpA)	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_GpA
k141_1890_1	1122609.AUGT01000003_gene2416	1.74e-30	120.0	COG1788@1|root,COG1788@2|Bacteria,2GK61@201174|Actinobacteria,4DPU7@85009|Propionibacteriales	201174|Actinobacteria	I	Coenzyme A transferase	cotA	-	2.8.3.12	ko:K01039	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
k141_1981_1	857293.CAAU_1572	1.59e-73	231.0	COG0604@1|root,COG0604@2|Bacteria,1TQ4W@1239|Firmicutes,249C7@186801|Clostridia,36ER7@31979|Clostridiaceae	186801|Clostridia	C	alcohol dehydrogenase	kdd	-	1.4.1.11	ko:K18012	ko00310,map00310	-	R03349	RC00888	ko00000,ko00001,ko01000	-	-	-	ADH_zinc_N
k141_1621_1	1123054.KB907706_gene2369	7.06e-84	263.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,1RR2W@1236|Gammaproteobacteria,1X0AF@135613|Chromatiales	135613|Chromatiales	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k141_2161_1	391008.Smal_1474	7.87e-06	49.3	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,1RNQ9@1236|Gammaproteobacteria,1X410@135614|Xanthomonadales	135614|Xanthomonadales	S	Ubiquinone biosynthesis protein	aarF	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1
k141_2161_2	1121405.dsmv_2025	5.76e-27	100.0	COG3478@1|root,COG3478@2|Bacteria,1P0EH@1224|Proteobacteria,431E0@68525|delta/epsilon subdivisions,2WWIK@28221|Deltaproteobacteria,2MNXS@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_2790_1	1304880.JAGB01000001_gene974	1.03e-67	230.0	COG0209@1|root,COG1372@1|root,COG0209@2|Bacteria,COG1372@2|Bacteria,1TPFH@1239|Firmicutes,249EN@186801|Clostridia	186801|Clostridia	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdJ	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Intein_splicing,LAGLIDADG_3,Ribonuc_red_2_N,Ribonuc_red_lgC,Ribonuc_red_lgN,TSCPD
k141_2070_1	273116.14324634	2.68e-37	138.0	COG1899@1|root,arCOG04142@2157|Archaea,2XSTD@28890|Euryarchaeota,241J4@183967|Thermoplasmata	183967|Thermoplasmata	J	Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue	dys	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
k141_2701_1	877455.Metbo_2467	3.3e-126	374.0	COG0422@1|root,arCOG02741@2157|Archaea,2XTMD@28890|Euryarchaeota,23NTD@183925|Methanobacteria	183925|Methanobacteria	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	-	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC_Rad_SAM
k141_2611_1	290315.Clim_2424	5.47e-33	130.0	COG0318@1|root,COG0318@2|Bacteria,1FDAB@1090|Chlorobi	1090|Chlorobi	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
k141_1440_1	290512.Paes_2297	1.05e-89	280.0	COG3547@1|root,COG3547@2|Bacteria,1FEII@1090|Chlorobi	1090|Chlorobi	L	transposase IS116 IS110 IS902 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k141_720_1	1415779.JOMH01000001_gene799	2.66e-64	207.0	COG3335@1|root,COG3335@2|Bacteria,1MW8A@1224|Proteobacteria,1RY10@1236|Gammaproteobacteria,1X3VX@135614|Xanthomonadales	135614|Xanthomonadales	L	Winged helix-turn helix	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_29,HTH_33
k141_1530_1	1123248.KB893326_gene1500	2.71e-20	91.3	COG3250@1|root,COG3250@2|Bacteria,4NFPC@976|Bacteroidetes,1IQJ2@117747|Sphingobacteriia	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 2 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
k141_361_1	864702.OsccyDRAFT_3183	2.49e-09	67.8	COG2931@1|root,COG5434@1|root,COG2931@2|Bacteria,COG5434@2|Bacteria,1G0JG@1117|Cyanobacteria,1HADF@1150|Oscillatoriales	1117|Cyanobacteria	M	Pectate lyase superfamily protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1349,DUF4347,Pectate_lyase_3
k141_2162_1	1121405.dsmv_0129	3.37e-36	135.0	COG2768@1|root,COG2768@2|Bacteria,1R08Q@1224|Proteobacteria,43CRC@68525|delta/epsilon subdivisions,2X7YY@28221|Deltaproteobacteria,2MPKX@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
k141_811_1	345219.Bcoa_0113	9.38e-62	214.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,4H9S5@91061|Bacilli,1ZCDJ@1386|Bacillus	91061|Bacilli	P	COG0474 Cation transport ATPase	yloB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	iYO844.BSU15650	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k141_1984_1	717774.Marme_1857	8.26e-26	105.0	COG2826@1|root,COG2826@2|Bacteria,1MWI0@1224|Proteobacteria,1RRSE@1236|Gammaproteobacteria,1XJAX@135619|Oceanospirillales	135619|Oceanospirillales	L	Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	HTH_38,rve
k141_2431_1	1117958.PE143B_0103730	1.66e-08	57.4	COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,1S3M6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	NT	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP	-	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR,CheR_N
k141_992_1	1236973.JCM9157_5012	5.21e-23	97.4	COG1484@1|root,COG1484@2|Bacteria,1TRWF@1239|Firmicutes,4HC07@91061|Bacilli,1ZQUF@1386|Bacillus	91061|Bacilli	L	Bacterial dnaA  protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
k141_1892_1	3750.XP_008387315.1	4.57e-27	118.0	COG2801@1|root,KOG1075@1|root,KOG0017@2759|Eukaryota,KOG1075@2759|Eukaryota,37Q53@33090|Viridiplantae,3GHAQ@35493|Streptophyta,4JSM9@91835|fabids	35493|Streptophyta	L	ribonuclease H protein At1g65750	-	-	-	-	-	-	-	-	-	-	-	-	DUF4283,RVT_1,RVT_3,zf-RVT
k141_1985_1	643648.Slip_0735	5.98e-66	213.0	COG1900@1|root,COG1900@2|Bacteria,1TRBF@1239|Firmicutes,248FE@186801|Clostridia,42KBD@68298|Syntrophomonadaceae	186801|Clostridia	S	Homocysteine biosynthesis enzyme, sulfur-incorporation	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,HcyBio
k141_543_1	1045858.Bint_1533	3.69e-109	337.0	COG5511@1|root,COG5511@2|Bacteria	2|Bacteria	F	Phage portal protein, lambda family	JD73_18735	-	-	-	-	-	-	-	-	-	-	-	Phage_portal_2
k141_2255_2	82654.Pse7367_2950	6.55e-54	180.0	COG1351@1|root,COG1351@2|Bacteria,1G3FM@1117|Cyanobacteria	1117|Cyanobacteria	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant	thyX	-	2.1.1.148	ko:K03465	ko00240,ko00670,ko01100,map00240,map00670,map01100	-	R06613	RC00022,RC00332	ko00000,ko00001,ko01000	-	-	-	Thy1
k141_1893_2	458233.MCCL_1177	1.59e-20	90.9	COG0095@1|root,COG0095@2|Bacteria,1TQ5U@1239|Firmicutes,4HABG@91061|Bacilli,4GXSA@90964|Staphylococcaceae	91061|Bacilli	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation	lipM	GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016415,GO:0016740,GO:0016746,GO:0016747,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
k141_2613_1	644281.MFS40622_0212	1.39e-23	102.0	COG1941@1|root,arCOG02472@2157|Archaea,2XV6A@28890|Euryarchaeota,23QG6@183939|Methanococci	183939|Methanococci	C	PFAM NADH ubiquinone oxidoreductase 20 kDa subunit	-	-	1.8.98.5	ko:K14128	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	Oxidored_q6
k141_2256_1	561230.PC1_2719	8.79e-29	116.0	COG0111@1|root,COG0111@2|Bacteria,1NU4B@1224|Proteobacteria,1T1T1@1236|Gammaproteobacteria,1MT43@122277|Pectobacterium	1236|Gammaproteobacteria	C	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	1.1.1.310,1.1.1.399,1.1.1.95	ko:K00058,ko:K16843	ko00260,ko00270,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513,R05693	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k141_5_1	456320.Mvol_0365	5.47e-58	189.0	COG1830@1|root,arCOG04044@2157|Archaea,2XTBQ@28890|Euryarchaeota,23QJD@183939|Methanococci	183939|Methanococci	E	Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids	aroA'	-	2.2.1.10,4.1.2.13	ko:K16306	ko00010,ko00030,ko00051,ko00400,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00400,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001	R01068,R01070,R02568,R08568	RC00438,RC00439,RC00721,RC02301	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
k141_1082_1	760568.Desku_1207	3.73e-184	530.0	COG1884@1|root,COG1884@2|Bacteria,1TQAD@1239|Firmicutes,24BDK@186801|Clostridia,260X7@186807|Peptococcaceae	186801|Clostridia	I	TIGRFAM methylmalonyl-CoA mutase N-terminal domain	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
k141_2614_1	517418.Ctha_1262	1.88e-11	69.7	COG1233@1|root,COG1233@2|Bacteria,1FDM1@1090|Chlorobi	1090|Chlorobi	Q	FAD dependent oxidoreductase	-	-	5.2.1.13	ko:K09835	ko00906,ko01100,ko01110,map00906,map01100,map01110	M00097	R07512	RC01960	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase,NAD_binding_8
k141_1802_1	404380.Gbem_2082	3.03e-06	53.9	COG1397@1|root,COG1397@2|Bacteria,1NTUR@1224|Proteobacteria,42NWG@68525|delta/epsilon subdivisions,2WJYQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	ADP-ribosylglycohydrolase	-	-	3.2.2.24	ko:K05521	-	-	-	-	ko00000,ko01000	-	-	-	ADP_ribosyl_GH
k141_2343_1	933262.AXAM01000050_gene3482	2.04e-85	269.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,42NCR@68525|delta/epsilon subdivisions,2WKMY@28221|Deltaproteobacteria,2MHTZ@213118|Desulfobacterales	28221|Deltaproteobacteria	V	ABC transporter transmembrane region	-	-	-	ko:K06147,ko:K18889	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k141_813_1	1236000.L0AQQ6_9CAUD	2.72e-70	236.0	4QB9Y@10239|Viruses,4QWGZ@35237|dsDNA viruses  no RNA stage,4QPTT@28883|Caudovirales,4QJD7@10662|Myoviridae	10662|Myoviridae	S	hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_273_2	203119.Cthe_2796	1.33e-22	98.6	COG0674@1|root,COG0674@2|Bacteria,1VS48@1239|Firmicutes,25E5U@186801|Clostridia,3WIBC@541000|Ruminococcaceae	186801|Clostridia	C	ferredoxin oxidoreductase	porA	GO:0003674,GO:0003824,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016491,GO:0016625,GO:0016903,GO:0019752,GO:0033609,GO:0033611,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:1901575	1.2.7.1,1.2.7.10	ko:K00169,ko:K19070	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
k141_544_2	941449.dsx2_0463	1.27e-58	191.0	COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,42N9Z@68525|delta/epsilon subdivisions,2WIKQ@28221|Deltaproteobacteria,2M9HW@213115|Desulfovibrionales	28221|Deltaproteobacteria	I	PFAM 6-phosphogluconate dehydrogenase NAD-binding	-	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
k141_2433_1	1262449.CP6013_3944	8.01e-08	58.5	COG0603@1|root,COG0603@2|Bacteria,1TP4Z@1239|Firmicutes,2497A@186801|Clostridia,36DMD@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	QueC
k141_2164_1	1219072.VHA01S_028_00200	1.87e-05	49.3	COG0863@1|root,COG0863@2|Bacteria,1R7KV@1224|Proteobacteria,1RZ25@1236|Gammaproteobacteria,1XUTY@135623|Vibrionales	135623|Vibrionales	L	DNA methylase	VP0394	-	2.1.1.72	ko:K00571	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
k141_1987_1	195103.CPF_1221	5.27e-68	234.0	COG3250@1|root,COG3250@2|Bacteria,1TPDC@1239|Firmicutes,248H7@186801|Clostridia,36F2A@31979|Clostridiaceae	186801|Clostridia	G	family 2, TIM barrel	lacZ	-	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	Bgal_small_N,Big_4,DUF4981,FIVAR,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N,Laminin_G_3,NPCBM
k141_1824_1	456320.Mvol_1263	2.73e-112	349.0	COG1148@1|root,arCOG02235@2157|Archaea,2XT3X@28890|Euryarchaeota,23QK4@183939|Methanococci	183939|Methanococci	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Pyr_redox_2
k141_1560_1	926569.ANT_22340	1.99e-92	290.0	COG2211@1|root,COG2211@2|Bacteria,2G6RZ@200795|Chloroflexi	200795|Chloroflexi	G	MFS/sugar transport protein	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
k141_1495_1	985053.VMUT_2060	6.04e-37	139.0	COG0086@1|root,arCOG04256@2157|Archaea,2XPSD@28889|Crenarchaeota	28889|Crenarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA2	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03042	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb1_5
k141_1121_1	563040.Saut_1467	4.82e-11	63.9	COG1610@1|root,COG1610@2|Bacteria,1RGZS@1224|Proteobacteria,42SH8@68525|delta/epsilon subdivisions,2YPDX@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	GatB Yqey family protein	-	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
k141_2292_1	1198114.AciX9_1471	3.05e-141	422.0	COG0556@1|root,COG0556@2|Bacteria,3Y31K@57723|Acidobacteria,2JHY9@204432|Acidobacteriia	204432|Acidobacteriia	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
k141_1296_1	631362.Thi970DRAFT_03950	1.16e-35	135.0	COG3039@1|root,COG3039@2|Bacteria,1NDMF@1224|Proteobacteria,1SNJM@1236|Gammaproteobacteria,1X0QT@135613|Chromatiales	135613|Chromatiales	L	PFAM Transposase	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_129_1	255470.cbdbA1077	1.65e-29	122.0	COG0045@1|root,COG1042@1|root,COG1670@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1670@2|Bacteria,2G5QB@200795|Chloroflexi	200795|Chloroflexi	C	PFAM CoA-binding domain protein	-	-	6.2.1.13	ko:K01905,ko:K09181,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
k141_1297_1	1183377.Py04_1598	1.5e-59	197.0	COG3276@1|root,arCOG01563@2157|Archaea,2XUKU@28890|Euryarchaeota,242PH@183968|Thermococci	183968|Thermococci	J	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA	eif2g	-	-	ko:K03242	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,eIF2_C
k141_934_1	439481.Aboo_0986	4.29e-12	70.5	COG0045@1|root,arCOG01337@2157|Archaea,2XTSC@28890|Euryarchaeota,3F389@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	ATP-grasp domain	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
k141_935_1	796940.HMPREF9628_01656	3.62e-59	202.0	COG3808@1|root,COG3808@2|Bacteria,1TNZI@1239|Firmicutes,248KS@186801|Clostridia,25QC5@186804|Peptostreptococcaceae	186801|Clostridia	C	Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
k141_1122_1	312284.A20C1_05176	9.87e-25	106.0	COG0778@1|root,COG0778@2|Bacteria,2I65Z@201174|Actinobacteria	201174|Actinobacteria	C	Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
k141_2468_1	10029.XP_007634688.1	8.66e-77	250.0	COG2036@1|root,COG5262@1|root,KOG1745@2759|Eukaryota,KOG1756@2759|Eukaryota,39ZTV@33154|Opisthokonta,3BPDH@33208|Metazoa,3D6BK@33213|Bilateria,48E1W@7711|Chordata,49B7M@7742|Vertebrata,3JGKY@40674|Mammalia,35PSM@314146|Euarchontoglires,4Q54X@9989|Rodentia	33208|Metazoa	B	Core histone H2A/H2B/H3/H4	HIST3H3	GO:0000228,GO:0000723,GO:0000726,GO:0000785,GO:0000786,GO:0000788,GO:0000790,GO:0003674,GO:0003676,GO:0003677,GO:0003682,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005694,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006303,GO:0006323,GO:0006325,GO:0006333,GO:0006334,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016233,GO:0022607,GO:0031333,GO:0031490,GO:0031491,GO:0031492,GO:0031497,GO:0031974,GO:0031981,GO:0032200,GO:0032459,GO:0032460,GO:0032991,GO:0032993,GO:0033554,GO:0034622,GO:0034641,GO:0034728,GO:0042592,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043254,GO:0043933,GO:0044085,GO:0044087,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044454,GO:0044464,GO:0044815,GO:0044877,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051129,GO:0051259,GO:0051262,GO:0051276,GO:0051290,GO:0051291,GO:0051716,GO:0060249,GO:0065003,GO:0065004,GO:0065007,GO:0065008,GO:0070013,GO:0071103,GO:0071704,GO:0071824,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363	-	ko:K11253,ko:K11275	ko05034,ko05202,ko05322,map05034,map05202,map05322	-	-	-	ko00000,ko00001,ko03036,ko04147	-	-	-	Histone
k141_2293_1	402880.MmarC5_1011	1.78e-90	284.0	KOG4482@1|root,arCOG00119@2157|Archaea,2XV24@28890|Euryarchaeota,23Q57@183939|Methanococci	183939|Methanococci	J	Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl- tRNA(Sec) required for selenoprotein biosynthesis	spcS	-	2.9.1.2	ko:K03341	ko00450,ko00970,map00450,map00970	-	R08224	RC02965,RC02966	ko00000,ko00001,ko01000	-	-	-	SepSecS
k141_2732_1	439235.Dalk_5190	4.54e-51	174.0	COG3547@1|root,COG3547@2|Bacteria,1NCHY@1224|Proteobacteria,42TM4@68525|delta/epsilon subdivisions,2WR4U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM transposase IS116 IS110 IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k141_487_1	378806.STAUR_3922	8.26e-16	81.6	COG4974@1|root,COG4974@2|Bacteria,1NY1A@1224|Proteobacteria,42NX3@68525|delta/epsilon subdivisions,2WME4@28221|Deltaproteobacteria,2YX9W@29|Myxococcales	28221|Deltaproteobacteria	L	IS66 C-terminal element	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
k141_2026_1	660470.Theba_2113	1.52e-26	109.0	COG3246@1|root,COG3246@2|Bacteria,2GCBA@200918|Thermotogae	200918|Thermotogae	S	beta-keto acid cleavage enzyme	-	-	2.3.1.247	ko:K18013	ko00310,map00310	-	R10564	RC02728,RC03199	ko00000,ko00001,ko01000	-	-	-	BKACE
k141_936_1	1536774.H70357_07815	1.19e-46	166.0	COG3344@1|root,COG3344@2|Bacteria,1TP9A@1239|Firmicutes,4HEIB@91061|Bacilli,26RJ8@186822|Paenibacillaceae	91061|Bacilli	L	DNA polymerase	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k141_2294_2	415426.Hbut_0054	1.06e-39	142.0	COG1405@1|root,arCOG01981@2157|Archaea,2XQ1T@28889|Crenarchaeota	28889|Crenarchaeota	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfb	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
k141_766_1	273057.SSO2786	2.35e-11	69.3	COG0668@1|root,arCOG01573@2157|Archaea,2XQ82@28889|Crenarchaeota	28889|Crenarchaeota	M	PFAM Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
k141_1123_1	1158292.JPOE01000005_gene1137	1.52e-18	90.5	COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,2VJ8P@28216|Betaproteobacteria,1KJ1B@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Aldehyde ferredoxin oxidoreductase	aorA	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
k141_2469_1	1121405.dsmv_1445	2.67e-106	327.0	COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,42M29@68525|delta/epsilon subdivisions,2WJ0X@28221|Deltaproteobacteria,2MI6Q@213118|Desulfobacterales	28221|Deltaproteobacteria	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
k141_1298_1	999630.TUZN_1765	1.2e-46	162.0	COG0087@1|root,arCOG04070@2157|Archaea,2XPNG@28889|Crenarchaeota	28889|Crenarchaeota	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rpl3	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
k141_1930_1	1443113.LC20_01955	1.25e-06	54.7	COG0477@1|root,COG2814@2|Bacteria,1N0KT@1224|Proteobacteria,1RYZC@1236|Gammaproteobacteria,41FAT@629|Yersinia	1236|Gammaproteobacteria	EGP	MFS/sugar transport protein	ydeE	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006857,GO:0008150,GO:0015833,GO:0016020,GO:0022857,GO:0035442,GO:0035672,GO:0035673,GO:0042886,GO:0042887,GO:0042938,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071916,GO:0071944,GO:1904680	-	-	-	-	-	-	-	-	-	-	MFS_1
k141_2733_1	1200557.JHWV01000002_gene187	3.08e-57	187.0	COG5012@1|root,COG5012@2|Bacteria,1V1P0@1239|Firmicutes,4H444@909932|Negativicutes	909932|Negativicutes	S	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,B12-binding_2
k141_1024_1	1235798.C817_02094	1.26e-93	294.0	COG1321@1|root,COG1321@2|Bacteria,1UZX6@1239|Firmicutes,248DA@186801|Clostridia	186801|Clostridia	K	iron dependent repressor	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_2470_1	868131.MSWAN_0018	3.95e-117	350.0	COG1350@1|root,arCOG01432@2157|Archaea,2Y845@28890|Euryarchaeota,23PBY@183925|Methanobacteria	183925|Methanobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	-	-	4.2.1.20	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k141_2109_1	1121422.AUMW01000010_gene1061	1.04e-14	74.7	COG1148@1|root,COG1249@1|root,COG1148@2|Bacteria,COG1249@2|Bacteria,1V5YJ@1239|Firmicutes,248CC@186801|Clostridia,2641A@186807|Peptococcaceae	186801|Clostridia	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Pyr_redox_2
k141_2109_2	1319815.HMPREF0202_00243	1.94e-31	124.0	COG1148@1|root,COG1148@2|Bacteria,378N8@32066|Fusobacteria	32066|Fusobacteria	C	NAD(P)-binding Rossmann-like domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Pyr_redox_2
k141_1125_1	1358423.N180_10070	8.89e-36	139.0	COG3525@1|root,COG3525@2|Bacteria,4NE08@976|Bacteroidetes,1IPND@117747|Sphingobacteriia	976|Bacteroidetes	G	Glycosyl hydrolase family 20, catalytic domain	-	-	3.2.1.52	ko:K12373	ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142	M00079	R00022,R06004,R11316	RC00049	ko00000,ko00001,ko00002,ko01000,ko03110	-	GH20	-	F5_F8_type_C,Fn3_assoc,Glyco_hydro_20,Glyco_hydro_20b
k141_132_1	247490.KSU1_B0142	1.89e-75	236.0	COG1830@1|root,COG1830@2|Bacteria,2IWUP@203682|Planctomycetes	203682|Planctomycetes	G	DeoC/LacD family aldolase	-	-	4.1.2.13	ko:K11645	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
k141_2378_1	644282.Deba_1334	4.47e-06	53.9	COG4412@1|root,COG4412@2|Bacteria,1RKAD@1224|Proteobacteria,43ARU@68525|delta/epsilon subdivisions,2X65X@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Immune inhibitor A peptidase M6	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M6
k141_2110_1	65071.PYU1_T005849	7.26e-41	155.0	2CMAY@1|root,2QPU8@2759|Eukaryota,1MD49@121069|Pythiales	121069|Pythiales	S	Glycosyl hydrolase. Source PGD	-	-	-	-	-	-	-	-	-	-	-	-	Cellulase
k141_2296_1	1382306.JNIM01000001_gene2684	7.67e-32	124.0	COG0451@1|root,COG0451@2|Bacteria	2|Bacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	-	-	-	-	-	-	-	-	-	-	-	-	3Beta_HSD,Epimerase,NAD_binding_10
k141_40_1	1459636.NTE_00355	6.56e-57	195.0	COG0459@1|root,arCOG01257@2157|Archaea,41SDG@651137|Thaumarchaeota	2157|Archaea	O	PFAM TCP-1 cpn60 chaperonin family	thsA	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0044183,GO:0051082,GO:0061077	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
k141_2379_1	693979.Bache_0238	1.91e-24	107.0	COG1472@1|root,COG1472@2|Bacteria,4NE90@976|Bacteroidetes,2FMCU@200643|Bacteroidia,4AK8A@815|Bacteroidaceae	976|Bacteroidetes	G	glycosyl hydrolase, family 3	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
k141_580_1	1121918.ARWE01000001_gene975	2.46e-51	174.0	COG4597@1|root,COG4597@2|Bacteria,1MV0S@1224|Proteobacteria,42NSB@68525|delta/epsilon subdivisions,2WIKP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K09970	ko02010,map02010	M00232	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	BPD_transp_1
k141_1025_1	679926.Mpet_0690	4.88e-32	127.0	COG0500@1|root,COG1846@1|root,arCOG01786@2157|Archaea,arCOG03182@2157|Archaea	2157|Archaea	K	Regulatory protein MarR	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2,Methyltransf_11,Methyltransf_31
k141_899_1	485913.Krac_9178	5.84e-78	244.0	COG2801@1|root,COG2801@2|Bacteria	2|Bacteria	L	transposition	-	-	-	-	-	-	-	-	-	-	-	-	rve
k141_27_1	118005.AWNK01000010_gene289	4.44e-25	100.0	COG1815@1|root,COG1815@2|Bacteria	2|Bacteria	N	bacterial-type flagellum-dependent cell motility	flgB	-	-	ko:K02387	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod
k141_844_1	999630.TUZN_1581	3.54e-57	192.0	COG0358@1|root,arCOG04281@2157|Archaea,2XPXM@28889|Crenarchaeota	28889|Crenarchaeota	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Toprim_4
k141_515_2	926561.KB900619_gene2424	3.75e-05	50.4	COG3634@1|root,COG3634@2|Bacteria,1V40Z@1239|Firmicutes,24JKA@186801|Clostridia,3WAU1@53433|Halanaerobiales	186801|Clostridia	O	TIGRFAM Glutaredoxin-like domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_3
k141_1526_1	933262.AXAM01000048_gene2601	7.01e-61	209.0	COG2937@1|root,COG2937@2|Bacteria,1MWZ6@1224|Proteobacteria,42MN4@68525|delta/epsilon subdivisions,2WJJ5@28221|Deltaproteobacteria,2MHRG@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Belongs to the GPAT DAPAT family	plsB	-	2.3.1.15	ko:K00631	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
k141_160_1	644282.Deba_1534	7.78e-198	559.0	COG0183@1|root,COG0183@2|Bacteria,1MU8C@1224|Proteobacteria,42N6X@68525|delta/epsilon subdivisions,2WJIE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k141_2668_1	1291050.JAGE01000001_gene2910	9.35e-16	75.5	2EGZP@1|root,33ART@2|Bacteria	2|Bacteria	S	YopX protein	-	-	-	-	-	-	-	-	-	-	-	-	YopX
k141_2217_1	1403819.BATR01000069_gene2031	1.94e-33	134.0	COG1470@1|root,COG1749@1|root,COG3291@1|root,COG3506@1|root,COG3533@1|root,COG1470@2|Bacteria,COG1749@2|Bacteria,COG3291@2|Bacteria,COG3506@2|Bacteria,COG3533@2|Bacteria,46SQ1@74201|Verrucomicrobia,2IV3A@203494|Verrucomicrobiae	203494|Verrucomicrobiae	N	Erythromycin esterase	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_793_1	1094980.Mpsy_2729	1.46e-71	228.0	COG0689@1|root,arCOG01575@2157|Archaea,2XVHI@28890|Euryarchaeota,2N95P@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'- 5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails	rrp41	-	-	ko:K11600	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	RNase_PH,RNase_PH_C
k141_1693_1	357804.Ping_2652	1.61e-89	273.0	COG2826@1|root,COG2826@2|Bacteria,1MWI0@1224|Proteobacteria,1RRSE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	IS30 family	ISPlu1B	-	-	ko:K07482	-	-	-	-	ko00000	-	-	-	HTH_38,rve
k141_162_2	1056495.Calag_0228	3.62e-51	180.0	COG4231@1|root,arCOG01609@2157|Archaea,2XPN3@28889|Crenarchaeota	28889|Crenarchaeota	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,POR_N,TPP_enzyme_C
k141_516_3	120017.I2FQV4	1.09e-31	126.0	29YJK@1|root,2RXU4@2759|Eukaryota,39RWE@33154|Opisthokonta,3NXAF@4751|Fungi,3V0MQ@5204|Basidiomycota,3N0J0@452284|Ustilaginomycotina	4751|Fungi	L	genome maintenance protein	MGM101	GO:0000002,GO:0000229,GO:0000262,GO:0000725,GO:0000733,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005694,GO:0005737,GO:0005739,GO:0005759,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007005,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016043,GO:0031974,GO:0032042,GO:0032392,GO:0033554,GO:0034641,GO:0035690,GO:0036297,GO:0042221,GO:0042493,GO:0042645,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043504,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070013,GO:0070887,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363	-	-	-	-	-	-	-	-	-	-	Mgm101p
k141_1325_1	177437.HRM2_47440	2.33e-36	136.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MQ0@68525|delta/epsilon subdivisions,2WISW@28221|Deltaproteobacteria,2MIUG@213118|Desulfobacterales	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k141_1325_2	671143.DAMO_1932	7.2e-18	84.7	COG0845@1|root,COG0845@2|Bacteria,2NPS3@2323|unclassified Bacteria	2|Bacteria	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_D23
k141_1048_1	1463861.JNXE01000008_gene9386	3.97e-65	214.0	COG0366@1|root,COG0366@2|Bacteria,2GN52@201174|Actinobacteria	201174|Actinobacteria	G	Alpha amylase catalytic	amyA	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase
k141_425_1	926556.Echvi_3203	1.09e-55	188.0	COG3385@1|root,COG5421@1|root,COG3385@2|Bacteria,COG5421@2|Bacteria,4NXT2@976|Bacteroidetes	976|Bacteroidetes	L	hmm pf01609	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k141_1155_1	529709.PYCH_06880	7.59e-94	295.0	COG2414@1|root,arCOG00709@2157|Archaea,2Y2PK@28890|Euryarchaeota,242X9@183968|Thermococci	183968|Thermococci	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
k141_1528_1	5932.XP_004031405.1	1.23e-12	70.9	KOG0084@1|root,KOG0084@2759|Eukaryota,3ZCZ3@5878|Ciliophora	5878|Ciliophora	U	Rab subfamily of small GTPases	-	-	-	ko:K07874	ko05134,map05134	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
k141_164_1	159749.K0TP24	1.6e-47	172.0	COG2801@1|root,2QT1S@2759|Eukaryota	2759|Eukaryota	L	transposition	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1,rve
k141_2669_1	292.DM42_4494	9.78e-05	50.1	COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,2VKK2@28216|Betaproteobacteria,1K61X@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Iron-containing alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Fe-ADH
k141_795_1	886293.Sinac_1208	2.26e-39	144.0	COG1861@1|root,COG1861@2|Bacteria,2J3F7@203682|Planctomycetes	203682|Planctomycetes	M	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k141_426_2	1131462.DCF50_p945	1.79e-64	212.0	COG3344@1|root,COG3344@2|Bacteria,1TP9A@1239|Firmicutes,248M4@186801|Clostridia,263T5@186807|Peptococcaceae	186801|Clostridia	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k141_1529_1	264732.Moth_0887	2.97e-54	197.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,247JN@186801|Clostridia,42EJU@68295|Thermoanaerobacterales	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k141_2416_1	153948.NAL212_2955	3.34e-64	206.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2VHER@28216|Betaproteobacteria,372VZ@32003|Nitrosomonadales	28216|Betaproteobacteria	L	PFAM Integrase, catalytic	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
k141_2323_1	439235.Dalk_2742	3.37e-50	175.0	COG0571@1|root,COG0613@1|root,COG0571@2|Bacteria,COG0613@2|Bacteria,1MUQ6@1224|Proteobacteria,42MIP@68525|delta/epsilon subdivisions,2X73H@28221|Deltaproteobacteria,2MII1@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	-	3.1.26.3,3.1.3.97	ko:K03685,ko:K07053	ko03008,ko05205,map03008,map05205	-	R00188,R11188	RC00078	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	PHP,Ribonucleas_3_3,dsrm
k141_600_1	631362.Thi970DRAFT_03189	1.47e-09	65.1	COG4974@1|root,COG4974@2|Bacteria,1NY1A@1224|Proteobacteria,1RN33@1236|Gammaproteobacteria,1WXGD@135613|Chromatiales	135613|Chromatiales	L	PFAM transposase IS66	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
k141_2054_1	402881.Plav_1674	2.99e-45	157.0	COG2267@1|root,COG2267@2|Bacteria,1R41P@1224|Proteobacteria,2TRY2@28211|Alphaproteobacteria,1JQMR@119043|Rhodobiaceae	28211|Alphaproteobacteria	I	Serine aminopeptidase, S33	MA20_16685	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
k141_2671_1	909663.KI867149_gene3394	1.71e-47	163.0	COG1013@1|root,COG1013@2|Bacteria,1MUY9@1224|Proteobacteria,42MQY@68525|delta/epsilon subdivisions,2WJGJ@28221|Deltaproteobacteria,2MQUN@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	ferredoxin oxidoreductase beta subunit	-	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
k141_1959_1	1134413.ANNK01000103_gene885	5.48e-91	270.0	28H95@1|root,2Z7KY@2|Bacteria,1TQTR@1239|Firmicutes,4HB82@91061|Bacilli,1ZDT7@1386|Bacillus	91061|Bacilli	S	Protein of unknown function (DUF4256)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4256
k141_2417_1	309803.CTN_0271	3.69e-35	132.0	COG0067@1|root,COG0067@2|Bacteria	2|Bacteria	E	L-glutamate biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	GATase_2,GATase_6
k141_428_1	1056495.Calag_0506	6.88e-35	131.0	COG1650@1|root,arCOG01616@2157|Archaea,2XPQP@28889|Crenarchaeota	28889|Crenarchaeota	J	D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo	dtdA	-	3.1.1.96	ko:K09716	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_deacylase
k141_601_1	272844.PAB0187	2.83e-60	210.0	COG0480@1|root,arCOG01559@2157|Archaea,2XUMQ@28890|Euryarchaeota,243B9@183968|Thermococci	183968|Thermococci	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K03234	ko04152,ko04921,map04152,map04921	-	-	-	ko00000,ko00001,ko03012,ko04147	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k141_1050_1	281687.CJA31272	7.72e-12	65.1	2EA4H@1|root,2SGDU@2759|Eukaryota,3A53V@33154|Opisthokonta	33154|Opisthokonta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_2055_1	879212.DespoDRAFT_01334	7.07e-43	157.0	COG3852@1|root,COG3852@2|Bacteria,1NTTH@1224|Proteobacteria,42MC9@68525|delta/epsilon subdivisions,2WIYS@28221|Deltaproteobacteria,2MHU3@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	2.7.13.3	ko:K07709	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS_9
k141_972_1	316274.Haur_4461	3.63e-59	207.0	COG1543@1|root,COG1543@2|Bacteria,2GBQW@200795|Chloroflexi,3764R@32061|Chloroflexia	32061|Chloroflexia	G	Belongs to the glycosyl hydrolase 57 family	-	-	2.4.1.18	ko:K16149	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000	-	GH57	-	DUF1957,Glyco_hydro_57
k141_2133_1	1365176.N186_04310	5.75e-67	225.0	COG0574@1|root,arCOG01111@2157|Archaea,2XPWQ@28889|Crenarchaeota	28889|Crenarchaeota	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k141_1158_1	521045.Kole_0486	1.5e-61	201.0	COG2055@1|root,COG2055@2|Bacteria,2GDVH@200918|Thermotogae	200918|Thermotogae	C	Belongs to the LDH2 MDH2 oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Ldh_2
k141_2679_1	386456.JQKN01000002_gene2482	2.72e-101	315.0	COG1331@1|root,arCOG02007@2157|Archaea,2XU5Q@28890|Euryarchaeota	28890|Euryarchaeota	O	COG1331 Highly conserved protein containing a thioredoxin domain	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
k141_337_1	487521.OCU_06160	3.29e-69	226.0	COG0405@1|root,COG0405@2|Bacteria,2GJYW@201174|Actinobacteria,2354G@1762|Mycobacteriaceae	201174|Actinobacteria	E	gamma-glutamyltransferase	ggtA	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k141_1699_1	2850.Phatr32511	2.33e-12	72.4	2D2UX@1|root,2SP3U@2759|Eukaryota,2XG67@2836|Bacillariophyta	2836|Bacillariophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_2330_1	639282.DEFDS_0188	1.96e-59	196.0	COG0846@1|root,COG0846@2|Bacteria,2GFEB@200930|Deferribacteres	200930|Deferribacteres	K	Sir2 family	-	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
k141_2583_1	1232453.BAIF02000010_gene3278	2.22e-42	161.0	COG1882@1|root,COG1882@2|Bacteria,1TPTF@1239|Firmicutes,247YY@186801|Clostridia,269HP@186813|unclassified Clostridiales	186801|Clostridia	C	Pyruvate formate lyase-like	-	-	2.3.1.54,4.3.99.4	ko:K00656,ko:K20038	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
k141_1970_1	1158318.ATXC01000001_gene941	1.07e-137	411.0	COG0074@1|root,COG0372@1|root,COG0074@2|Bacteria,COG0372@2|Bacteria,2G3P0@200783|Aquificae	200783|Aquificae	C	ATP-citrate synthase (ATP-citrate (Pro-S-)-lyase)(Citrate cleavage enzyme)	-	-	2.3.3.8	ko:K15230	ko00020,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00720,map01100,map01110,map01120,map01130,map01200	M00173	R00352	RC00004,RC00067	ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt,Ligase_CoA
k141_1423_1	680198.SCAB_89071	1.13e-36	141.0	COG0028@1|root,COG0028@2|Bacteria,2GKU4@201174|Actinobacteria	201174|Actinobacteria	E	Acetolactate synthase	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k141_1331_1	289376.THEYE_A1344	2.63e-44	165.0	COG0417@1|root,COG0417@2|Bacteria,3J19U@40117|Nitrospirae	40117|Nitrospirae	L	DNA polymerase type-B family	-	-	2.7.7.7	ko:K02336	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol_B,DNA_pol_B_exo1
k141_2504_1	246969.TAM4_1878	2.27e-15	80.5	COG1530@1|root,arCOG00321@2157|Archaea,2XU9U@28890|Euryarchaeota,243NV@183968|Thermococci	183968|Thermococci	L	Putative modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
k141_2227_1	37727.XP_002149624.1	4.16e-05	45.8	COG1028@1|root,KOG0725@2759|Eukaryota,399X5@33154|Opisthokonta,3NXUK@4751|Fungi,3QMZ9@4890|Ascomycota,20GQI@147545|Eurotiomycetes,3S8KF@5042|Eurotiales	4751|Fungi	Q	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k141_1971_1	909663.KI867149_gene3270	1.93e-11	64.7	COG4733@1|root,COG4733@2|Bacteria,1NPTD@1224|Proteobacteria,42Y31@68525|delta/epsilon subdivisions,2WSU6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Fibronectin type 3 domain	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_1866_1	1121405.dsmv_0617	1.42e-34	132.0	COG1148@1|root,COG1148@2|Bacteria,1Q0ZF@1224|Proteobacteria,42NHH@68525|delta/epsilon subdivisions,2WJ6M@28221|Deltaproteobacteria,2MIS1@213118|Desulfobacterales	28221|Deltaproteobacteria	C	FAD dependent oxidoreductase	qmoA	-	-	ko:K16885	-	-	-	-	ko00000	-	-	-	FAD_oxidored,NAD_binding_8,Pyr_redox_2
k141_2331_1	159749.K0SPK0	2.4e-55	199.0	COG2801@1|root,2QT1S@2759|Eukaryota	2759|Eukaryota	L	transposition	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1,rve
k141_1058_1	1054217.TALC_00022	8.52e-11	67.8	COG0464@1|root,arCOG01308@2157|Archaea,2XSYR@28890|Euryarchaeota,241IB@183967|Thermoplasmata	183967|Thermoplasmata	O	Cell division protein 48 (CDC48) domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N
k141_523_1	933262.AXAM01000029_gene2755	3.52e-49	165.0	COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,42MCV@68525|delta/epsilon subdivisions,2WJI2@28221|Deltaproteobacteria,2MJCB@213118|Desulfobacterales	28221|Deltaproteobacteria	J	TIGRFAM tryptophanyl-tRNA synthetase	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
k141_1780_1	319225.Plut_0161	1.77e-93	289.0	COG0542@1|root,COG0542@2|Bacteria,1FDNV@1090|Chlorobi	1090|Chlorobi	O	PFAM AAA ATPase central domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA,Clp_N
k141_708_1	9541.XP_005554278.1	2.23e-07	53.9	COG2036@1|root,COG5262@1|root,KOG1744@1|root,KOG1744@2759|Eukaryota,KOG1756@2759|Eukaryota,KOG3467@2759|Eukaryota,3A1K0@33154|Opisthokonta,3BQBZ@33208|Metazoa,3D75E@33213|Bilateria,48E3B@7711|Chordata,49ATY@7742|Vertebrata,3JJ3H@40674|Mammalia,35PUC@314146|Euarchontoglires,4MRWB@9443|Primates,36AQY@314294|Cercopithecoidea	33208|Metazoa	B	Histone H2A	HIST1H2AD	GO:0000228,GO:0000785,GO:0000790,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005694,GO:0006325,GO:0006342,GO:0006355,GO:0006996,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016043,GO:0016458,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031974,GO:0031981,GO:0040029,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044454,GO:0044464,GO:0045814,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051276,GO:0060255,GO:0065007,GO:0070013,GO:0071840,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K11251	ko04217,ko05034,ko05322,map04217,map05034,map05322	-	-	-	ko00000,ko00001,ko03036,ko04147	-	-	-	CENP-T_C,Histone,Histone_H2A_C
k141_1332_1	589865.DaAHT2_1112	5.72e-44	160.0	COG0427@1|root,COG1670@1|root,COG0427@2|Bacteria,COG1670@2|Bacteria,1MUGE@1224|Proteobacteria,42MHC@68525|delta/epsilon subdivisions,2WINZ@28221|Deltaproteobacteria,2MI87@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Acetyl-CoA hydrolase transferase	-	-	-	-	-	-	-	-	-	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro,Acetyltransf_1,Acetyltransf_3
k141_1701_1	484019.THA_1415	2.2e-25	98.2	COG2185@1|root,COG2185@2|Bacteria,2GD2V@200918|Thermotogae	200918|Thermotogae	I	PFAM cobalamin B12-binding domain protein	-	-	5.4.99.2	ko:K01849	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
k141_1701_2	485916.Dtox_1909	3.69e-10	62.0	COG1884@1|root,COG1884@2|Bacteria,1TQAD@1239|Firmicutes,24BDK@186801|Clostridia,263HW@186807|Peptococcaceae	186801|Clostridia	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
k141_2762_1	1207063.P24_04455	0.000349	48.5	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2TRHH@28211|Alphaproteobacteria,2JRBS@204441|Rhodospirillales	204441|Rhodospirillales	T	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_9,Response_reg
k141_2507_1	285535.JOEY01000006_gene8154	1.65e-08	62.4	COG1960@1|root,COG1960@2|Bacteria,2GM1Q@201174|Actinobacteria	201174|Actinobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k141_1602_1	178306.PAE1729	1.85e-13	69.7	COG0185@1|root,arCOG04099@2157|Archaea,2XQBR@28889|Crenarchaeota	28889|Crenarchaeota	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rps19p	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
k141_2585_2	1122915.AUGY01000061_gene3759	4.39e-44	157.0	COG3677@1|root,COG3677@2|Bacteria,1V4D1@1239|Firmicutes,4HJM6@91061|Bacilli,26XVB@186822|Paenibacillaceae	91061|Bacilli	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1595,Zn_Tnp_IS1595
k141_709_1	697281.Mahau_2031	4.06e-132	397.0	COG1472@1|root,COG1472@2|Bacteria,1TP0T@1239|Firmicutes,24932@186801|Clostridia,42I0Z@68295|Thermoanaerobacterales	186801|Clostridia	G	Fibronectin type III-like domain	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
k141_1702_1	391623.TERMP_00651	4.05e-39	133.0	COG1917@1|root,arCOG03004@2157|Archaea,2XYUR@28890|Euryarchaeota	28890|Euryarchaeota	S	PFAM Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k141_525_1	595460.RRSWK_05984	7.39e-170	488.0	COG3344@1|root,COG3344@2|Bacteria,2J0GH@203682|Planctomycetes	203682|Planctomycetes	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k141_2684_1	386456.JQKN01000001_gene1821	3.26e-64	206.0	COG1668@1|root,arCOG01462@2157|Archaea,2Y3YK@28890|Euryarchaeota	28890|Euryarchaeota	C	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
k141_711_1	351160.RCIX685	3.58e-52	186.0	COG0464@1|root,arCOG01308@2157|Archaea,2XSYR@28890|Euryarchaeota,2N91U@224756|Methanomicrobia	224756|Methanomicrobia	O	Cell division protein 48 (CDC48), domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N
k141_437_1	395961.Cyan7425_1154	7.17e-83	275.0	COG0501@1|root,COG0501@2|Bacteria,1G16J@1117|Cyanobacteria,3KGMM@43988|Cyanothece	1117|Cyanobacteria	O	peptidase M48, Ste24p	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48,TPR_19
k141_2139_1	498761.HM1_3150	2.31e-09	56.6	2E4EA@1|root,32Z9I@2|Bacteria,1VG12@1239|Firmicutes,24R4R@186801|Clostridia	186801|Clostridia	S	ORF located using Blastx	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_2510_1	760011.Spico_1044	5.28e-55	194.0	COG0006@1|root,COG0673@1|root,COG0006@2|Bacteria,COG0673@2|Bacteria,2J6T7@203691|Spirochaetes	203691|Spirochaetes	E	Oxidoreductase family, C-terminal alpha beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k141_2685_1	443143.GM18_0538	9.57e-41	156.0	COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,42M8P@68525|delta/epsilon subdivisions,2X5K8@28221|Deltaproteobacteria,43TJJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	Collagenase	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3656,Peptidase_U32
k141_2438_1	604354.TSIB_0422	1.64e-12	72.8	COG0358@1|root,arCOG04281@2157|Archaea,2XTHB@28890|Euryarchaeota,242MR@183968|Thermococci	183968|Thermococci	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Toprim_4
k141_641_1	994573.T472_0205620	4.33e-96	295.0	COG2368@1|root,COG2368@2|Bacteria,1TQ70@1239|Firmicutes,248RP@186801|Clostridia,36QMU@31979|Clostridiaceae	186801|Clostridia	Q	4-hydroxyphenylacetate 3-hydroxylase C terminal	-	-	1.14.14.9	ko:K00483	ko00350,ko01120,ko01220,map00350,map01120,map01220	-	R02698,R03299	RC00046	ko00000,ko00001,ko01000	-	-	-	HpaB,HpaB_N
k141_1719_1	27923.ML199812a-PA	2.13e-29	124.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y9N@33154|Opisthokonta	33154|Opisthokonta	S	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k141_2704_1	1031288.AXAA01000014_gene396	2.56e-70	230.0	COG0519@1|root,COG0519@2|Bacteria,1TPG8@1239|Firmicutes,2487F@186801|Clostridia,36EFK@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase,tRNA_Me_trans
k141_907_1	1096546.WYO_0558	1.14e-14	78.6	COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,1JQYU@119045|Methylobacteriaceae	28211|Alphaproteobacteria	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
k141_1087_1	382464.ABSI01000005_gene1158	1.19e-50	172.0	COG2309@1|root,COG2309@2|Bacteria	2|Bacteria	E	aminopeptidase activity	pepS	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
k141_2077_2	984262.SGRA_3358	1.39e-48	171.0	COG0029@1|root,COG0029@2|Bacteria,4NGUE@976|Bacteroidetes,1IQPX@117747|Sphingobacteriia	976|Bacteroidetes	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	nadB	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k141_1932_1	326427.Cagg_3357	1.04e-09	65.5	COG4412@1|root,COG4412@2|Bacteria,2G622@200795|Chloroflexi,3758I@32061|Chloroflexia	32061|Chloroflexia	S	Immune inhibitor A peptidase M6	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M6
k141_2380_1	477974.Daud_1652	1.46e-34	132.0	COG1941@1|root,COG1941@2|Bacteria,1V21E@1239|Firmicutes,24GWD@186801|Clostridia,264VD@186807|Peptococcaceae	186801|Clostridia	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	-	-	1.8.98.5	ko:K14128	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	Oxidored_q6
k141_307_1	545243.BAEV01000016_gene2103	2.83e-74	238.0	COG1012@1|root,COG1012@2|Bacteria,1TP4S@1239|Firmicutes,247W7@186801|Clostridia,36DK7@31979|Clostridiaceae	186801|Clostridia	C	Belongs to the aldehyde dehydrogenase family	gapN	-	1.2.1.9	ko:K00131	ko00010,ko00030,ko01100,ko01120,ko01200,map00010,map00030,map01100,map01120,map01200	M00308,M00633	R01058	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k141_2474_1	397948.Cmaq_0710	3.21e-28	117.0	COG2414@1|root,arCOG00706@2157|Archaea,2XQ6E@28889|Crenarchaeota	28889|Crenarchaeota	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
k141_862_1	56780.SYN_00790	3.43e-56	189.0	COG3039@1|root,COG3039@2|Bacteria,1MVTU@1224|Proteobacteria,42Q03@68525|delta/epsilon subdivisions,2WMFQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Transposase domain (DUF772)	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k141_2298_1	1499967.BAYZ01000015_gene6575	1.18e-47	164.0	COG0846@1|root,COG0846@2|Bacteria,2NPJR@2323|unclassified Bacteria	2|Bacteria	K	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form	cobB	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
k141_679_1	714943.Mucpa_6582	2.39e-71	239.0	COG3533@1|root,COG3533@2|Bacteria,4NFW3@976|Bacteroidetes,1IR7T@117747|Sphingobacteriia	976|Bacteroidetes	S	coagulation factor 5 8 type	-	-	-	ko:K09955	-	-	-	-	ko00000	-	-	-	F5_F8_type_C,Glyco_hydro_127
k141_2557_1	1313304.CALK_1620	6.42e-33	126.0	COG1131@1|root,COG1131@2|Bacteria	2|Bacteria	V	ATPase activity	gldA	-	3.6.3.7	ko:K01990,ko:K09697	ko02010,ko02020,map02010,map02020	M00253,M00254	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.115	-	-	ABC_tran
k141_1128_1	642227.HA49_08560	4.18e-93	302.0	28JKJ@1|root,2Z9DD@2|Bacteria,1MUN2@1224|Proteobacteria,1RQIP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Phage P22-like portal protein	-	-	-	-	-	-	-	-	-	-	-	-	P22_portal
k141_863_1	439235.Dalk_4526	7.11e-37	140.0	COG1070@1|root,COG1070@2|Bacteria,1MW4A@1224|Proteobacteria,42Q1B@68525|delta/epsilon subdivisions,2WKJH@28221|Deltaproteobacteria,2MK4Y@213118|Desulfobacterales	28221|Deltaproteobacteria	G	FGGY family of carbohydrate kinases, N-terminal domain	-	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
k141_491_1	1322246.BN4_10933	1.52e-42	154.0	COG2204@1|root,COG3852@1|root,COG2204@2|Bacteria,COG3852@2|Bacteria,1R9WW@1224|Proteobacteria,42R68@68525|delta/epsilon subdivisions,2WMSV@28221|Deltaproteobacteria,2M9QN@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,Response_reg
k141_680_1	565033.GACE_0199	1.67e-52	181.0	COG0595@1|root,arCOG00547@2157|Archaea,2XTIB@28890|Euryarchaeota,246UA@183980|Archaeoglobi	183980|Archaeoglobi	J	PFAM RNA-metabolising metallo-beta-lactamase	-	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	-
k141_2476_1	981369.JQMJ01000004_gene3557	3.03e-32	124.0	COG0179@1|root,COG0179@2|Bacteria,2GN2G@201174|Actinobacteria,2NM2M@228398|Streptacidiphilus	201174|Actinobacteria	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
k141_309_1	1074889.MADAR_180	1.49e-51	181.0	COG0018@1|root,COG0018@2|Bacteria,4NE7Q@976|Bacteroidetes,1HY2B@117743|Flavobacteriia,3IVG0@39782|Blattabacteriaceae	976|Bacteroidetes	J	DALR anticodon binding domain	argS	GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
k141_1933_1	1443113.LC20_00459	4.02e-09	57.0	COG0500@1|root,COG2226@2|Bacteria,1QUBD@1224|Proteobacteria,1T1S4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k141_1663_1	871963.Desdi_0372	1.07e-33	124.0	COG0348@1|root,COG0348@2|Bacteria,1UVRB@1239|Firmicutes,25I6A@186801|Clostridia,266AF@186807|Peptococcaceae	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_9
k141_681_1	706587.Desti_5031	4.13e-37	143.0	COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_20,Pyr_redox_2
k141_2383_1	1307761.L21SP2_2089	6.17e-89	281.0	COG3666@1|root,COG3666@2|Bacteria,2J98U@203691|Spirochaetes	203691|Spirochaetes	L	COG3666 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k141_1303_1	1121405.dsmv_2161	3.92e-100	306.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,42M52@68525|delta/epsilon subdivisions,2WIRK@28221|Deltaproteobacteria,2MHPV@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
k141_1503_2	352165.HMPREF7215_2744	1.53e-18	85.9	COG1502@1|root,COG1502@2|Bacteria,3TADN@508458|Synergistetes	508458|Synergistetes	I	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	-	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2,PLDc_N
k141_1030_1	10224.XP_006824138.1	4.44e-21	97.4	COG1283@1|root,2QQ3I@2759|Eukaryota,38DHE@33154|Opisthokonta,3BA55@33208|Metazoa,3CRFS@33213|Bilateria	33208|Metazoa	P	sodium-dependent phosphate transmembrane transporter activity	SLC34A2	GO:0001503,GO:0001655,GO:0001701,GO:0001822,GO:0003674,GO:0005215,GO:0005436,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005768,GO:0005819,GO:0005856,GO:0005886,GO:0005887,GO:0005902,GO:0005903,GO:0006066,GO:0006082,GO:0006725,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0006817,GO:0006820,GO:0006873,GO:0007275,GO:0007568,GO:0007584,GO:0008150,GO:0008152,GO:0008324,GO:0008509,GO:0009100,GO:0009605,GO:0009653,GO:0009719,GO:0009725,GO:0009743,GO:0009746,GO:0009750,GO:0009790,GO:0009792,GO:0009887,GO:0009986,GO:0009987,GO:0009991,GO:0010033,GO:0010035,GO:0010038,GO:0010243,GO:0010288,GO:0010966,GO:0012505,GO:0014070,GO:0015075,GO:0015077,GO:0015081,GO:0015103,GO:0015114,GO:0015291,GO:0015293,GO:0015294,GO:0015318,GO:0015321,GO:0015370,GO:0015630,GO:0015672,GO:0015698,GO:0016020,GO:0016021,GO:0016043,GO:0016137,GO:0016323,GO:0016324,GO:0016604,GO:0016607,GO:0016999,GO:0017144,GO:0019538,GO:0019725,GO:0019751,GO:0019752,GO:0019904,GO:0022607,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0030002,GO:0030165,GO:0030320,GO:0030643,GO:0030647,GO:0031224,GO:0031226,GO:0031253,GO:0031402,GO:0031410,GO:0031420,GO:0031526,GO:0031528,GO:0031667,GO:0031974,GO:0031981,GO:0031982,GO:0032026,GO:0032355,GO:0032501,GO:0032502,GO:0032870,GO:0032879,GO:0033189,GO:0033273,GO:0033993,GO:0034220,GO:0034284,GO:0034641,GO:0034762,GO:0034764,GO:0034765,GO:0034767,GO:0035435,GO:0035725,GO:0035864,GO:0042221,GO:0042301,GO:0042391,GO:0042430,GO:0042431,GO:0042475,GO:0042476,GO:0042493,GO:0042592,GO:0042802,GO:0042803,GO:0042995,GO:0043009,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043269,GO:0043270,GO:0043279,GO:0043434,GO:0043436,GO:0043627,GO:0043933,GO:0044070,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0044341,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044430,GO:0044444,GO:0044446,GO:0044451,GO:0044459,GO:0044463,GO:0044464,GO:0044877,GO:0045121,GO:0045177,GO:0045838,GO:0046483,GO:0046686,GO:0046689,GO:0046849,GO:0046872,GO:0046873,GO:0046983,GO:0048471,GO:0048513,GO:0048518,GO:0048646,GO:0048731,GO:0048771,GO:0048856,GO:0048878,GO:0050789,GO:0050801,GO:0050896,GO:0051049,GO:0051050,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0051716,GO:0055062,GO:0055081,GO:0055082,GO:0055083,GO:0055085,GO:0060359,GO:0060416,GO:0065003,GO:0065007,GO:0065008,GO:0070013,GO:0070887,GO:0071107,GO:0071241,GO:0071242,GO:0071248,GO:0071310,GO:0071312,GO:0071374,GO:0071407,GO:0071417,GO:0071495,GO:0071704,GO:0071840,GO:0071944,GO:0072001,GO:0072350,GO:0072501,GO:0072502,GO:0072505,GO:0072506,GO:0072686,GO:0072733,GO:0072734,GO:0097066,GO:0097187,GO:0097708,GO:0098589,GO:0098590,GO:0098655,GO:0098656,GO:0098657,GO:0098659,GO:0098660,GO:0098661,GO:0098662,GO:0098719,GO:0098739,GO:0098771,GO:0098805,GO:0098857,GO:0098858,GO:0098862,GO:0099587,GO:0120025,GO:0120038,GO:1901128,GO:1901135,GO:1901360,GO:1901564,GO:1901615,GO:1901652,GO:1901657,GO:1901684,GO:1901698,GO:1901699,GO:1901700,GO:1903793,GO:1903795,GO:1903797,GO:1903959,GO:1903961,GO:2000118,GO:2000120,GO:2000185,GO:2000187	-	ko:K14683	-	-	-	-	ko00000,ko02000,ko04147	2.A.58.1	-	-	Na_Pi_cotrans
k141_310_1	953739.SVEN_0030	1.94e-77	238.0	COG1024@1|root,COG1024@2|Bacteria,2GJ63@201174|Actinobacteria	201174|Actinobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	echA5	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
k141_1572_1	1172190.M947_04955	9.09e-38	138.0	COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,42MRV@68525|delta/epsilon subdivisions,2YNSU@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	C	COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
k141_1396_1	272844.PAB1578	1.47e-65	214.0	COG0076@1|root,arCOG00027@2157|Archaea,2XT09@28890|Euryarchaeota,243SU@183968|Thermococci	183968|Thermococci	E	Catalyzes the decarboxylation of L-aspartate to produce beta-alanine	mfnA	GO:0003674,GO:0003824,GO:0004068,GO:0004351,GO:0005488,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019842,GO:0030170,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0070279,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.1.1.11,4.1.1.25	ko:K18933	ko00350,ko00410,ko00680,ko00770,ko01100,ko01110,map00350,map00410,map00680,map00770,map01100,map01110	-	R00489,R00736	RC00299	ko00000,ko00001,ko01000	-	-	-	Pyridoxal_deC
k141_2736_1	401526.TcarDRAFT_2488	1.95e-44	157.0	COG0846@1|root,COG0846@2|Bacteria,1TQKD@1239|Firmicutes,4H3ZT@909932|Negativicutes	909932|Negativicutes	K	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form	cobB	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
k141_1211_1	521011.Mpal_2163	2.17e-15	72.8	COG1911@1|root,arCOG01752@2157|Archaea,2Y0CU@28890|Euryarchaeota,2NA2A@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM ribosomal protein L7Ae L30e S12e Gadd45	rpl30e	-	-	ko:K02908	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L7Ae
k141_1211_2	589924.Ferp_0758	7.84e-10	58.9	COG0195@1|root,arCOG01760@2157|Archaea,2XYAY@28890|Euryarchaeota,2468I@183980|Archaeoglobi	183980|Archaeoglobi	K	Participates in transcription termination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_2
k141_2558_1	525365.HMPREF0548_0556	3.87e-43	160.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,4H9S5@91061|Bacilli,3F3KP@33958|Lactobacillaceae	91061|Bacilli	P	P-type ATPase	pacL	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k141_215_1	321955.AAGP01000021_gene1945	4.61e-09	60.8	COG1484@1|root,COG1484@2|Bacteria,2IA1S@201174|Actinobacteria,4FAW5@85019|Brevibacteriaceae	201174|Actinobacteria	L	IstB-like ATP binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
k141_2301_1	706587.Desti_0627	3.02e-06	48.9	COG0614@1|root,COG0614@2|Bacteria,1N7EM@1224|Proteobacteria,42U5G@68525|delta/epsilon subdivisions,2WQ28@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
k141_865_1	935948.KE386495_gene2043	3.79e-52	179.0	COG0787@1|root,COG0787@2|Bacteria,1TNYY@1239|Firmicutes,2480T@186801|Clostridia,42EZ0@68295|Thermoanaerobacterales	186801|Clostridia	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1,5.1.1.18	ko:K01775,ko:K18348	ko00473,ko01100,ko01502,ko02020,map00473,map01100,map01502,map02020	M00652	R00401	RC00285	ko00000,ko00001,ko00002,ko01000,ko01011,ko01504	-	-	-	Acyl_transf_3,Ala_racemase_C,Ala_racemase_N
k141_138_1	944481.JAFP01000001_gene724	2.47e-12	68.2	COG0697@1|root,COG0697@2|Bacteria,1N024@1224|Proteobacteria,42NW9@68525|delta/epsilon subdivisions,2WJEJ@28221|Deltaproteobacteria,2M6M9@213113|Desulfurellales	28221|Deltaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k141_1665_1	1121007.AUML01000009_gene3730	1.74e-34	130.0	COG1073@1|root,COG1073@2|Bacteria,4NFRN@976|Bacteroidetes,1HWSK@117743|Flavobacteriia,2YJEP@290174|Aquimarina	976|Bacteroidetes	S	Hydrolases of the alpha beta superfamily	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	BAAT_C,Hydrolase_4
k141_443_1	572546.Arcpr_1586	4.9e-49	166.0	COG1927@1|root,arCOG04382@2157|Archaea,2XUX3@28890|Euryarchaeota,24626@183980|Archaeoglobi	183980|Archaeoglobi	C	Catalyzes the oxidation of methylene-H(4)MPT to methenyl-H(4)MPT( )	mtd	-	1.5.98.1	ko:K00319	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R04456	RC00202	ko00000,ko00001,ko00002,ko01000	-	-	-	MTD
k141_1431_1	243232.MJ_0743	6.6e-50	170.0	COG2048@1|root,arCOG00338@2157|Archaea,2XTWJ@28890|Euryarchaeota,23Q7G@183939|Methanococci	183939|Methanococci	C	heterodisulfide reductase	hdrB1	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
k141_1431_2	706587.Desti_5031	4.44e-05	45.8	COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_20,Pyr_redox_2
k141_1064_2	868131.MSWAN_2040	1.31e-27	105.0	COG1908@1|root,arCOG02475@2157|Archaea,2XY1E@28890|Euryarchaeota,23NY4@183925|Methanobacteria	183925|Methanobacteria	C	PFAM Methyl-viologen-reducing hydrogenase, delta subunit	mvhD1	-	1.8.98.5,1.8.98.6	ko:K14127	ko00680,map00680	-	R00019,R11943,R11944	RC00011	ko00000,ko00001,ko01000	-	-	-	FlpD
k141_2236_2	4513.MLOC_79484.1	1.38e-14	79.0	COG2801@1|root,KOG0017@2759|Eukaryota,37THH@33090|Viridiplantae,3GG2K@35493|Streptophyta,3M2IR@4447|Liliopsida,3IKX9@38820|Poales	35493|Streptophyta	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_2,gag_pre-integrs,rve
k141_719_1	278963.ATWD01000003_gene138	7.19e-06	53.9	COG3039@1|root,COG3039@2|Bacteria,3Y8N9@57723|Acidobacteria,2JNID@204432|Acidobacteriia	204432|Acidobacteriia	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k141_2337_1	573064.Mefer_1103	8.17e-33	118.0	COG1358@1|root,arCOG01751@2157|Archaea,2XX4C@28890|Euryarchaeota,23R1K@183939|Methanococci	183939|Methanococci	J	Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H ACA, box C D and box C' D' sRNAs	rpl7ae	GO:0000470,GO:0000491,GO:0000492,GO:0000966,GO:0001682,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005732,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030515,GO:0030677,GO:0032991,GO:0034470,GO:0034471,GO:0034512,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902494,GO:1902555,GO:1905348,GO:1990904	-	ko:K02936	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03009,ko03011	-	-	-	Ribosomal_L7Ae
k141_2391_1	626887.J057_02290	3.33e-99	305.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,1RR2W@1236|Gammaproteobacteria,465RW@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	COG3666 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k141_410_1	1144305.PMI02_03240	1.33e-20	89.0	COG3335@1|root,COG3335@2|Bacteria,1RDBN@1224|Proteobacteria,2VFA9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	transposable element conserved	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
k141_1438_1	868595.Desca_2641	3.29e-29	115.0	COG2131@1|root,COG2131@2|Bacteria,1V3PU@1239|Firmicutes,24HF0@186801|Clostridia,261R0@186807|Peptococcaceae	186801|Clostridia	F	PFAM Cytidine and deoxycytidylate deaminase zinc-binding region	comEB	-	3.5.4.12	ko:K01493	ko00240,ko01100,map00240,map01100	M00429	R01663	RC00074	ko00000,ko00001,ko00002,ko01000,ko02044	-	-	-	dCMP_cyt_deam_1
k141_2153_1	7668.SPU_007843-tr	2.93e-60	209.0	COG2801@1|root,KOG0017@2759|Eukaryota,38GIZ@33154|Opisthokonta,3BMWT@33208|Metazoa,3CTK8@33213|Bilateria	33208|Metazoa	L	genomic stop codons	-	-	-	-	-	-	-	-	-	-	-	-	Gag_p30,RNase_H,RVP,RVT_1,rve
k141_1243_2	1209989.TepiRe1_0341	1.52e-56	185.0	COG4656@1|root,COG4656@2|Bacteria,1TS9H@1239|Firmicutes,24DQ7@186801|Clostridia,42FJ0@68295|Thermoanaerobacterales	186801|Clostridia	C	Methylene-tetrahydrofolate reductase C terminal	-	-	-	-	-	-	-	-	-	-	-	iHN637.CLJU_RS18525	MTHFR_C
k141_82_1	552396.HMPREF0863_00713	2.19e-05	47.8	COG3871@1|root,COG3871@2|Bacteria,1V1KZ@1239|Firmicutes,3VUQQ@526524|Erysipelotrichia	526524|Erysipelotrichia	S	Pyridoxamine 5'-phosphate oxidase like	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_82_2	485916.Dtox_3059	2.25e-23	94.0	2DMZP@1|root,32UMQ@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF3795)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3795
k141_2154_1	439235.Dalk_1136	1.32e-111	339.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2WUG9@28221|Deltaproteobacteria,2MMW2@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
k141_624_1	1242864.D187_000193	1.1e-36	140.0	COG4191@1|root,COG4191@2|Bacteria,1R3RN@1224|Proteobacteria,42P11@68525|delta/epsilon subdivisions,2WJEK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HAMP,HATPase_c,PAS_4
k141_1072_1	596151.DesfrDRAFT_1898	1.14e-43	145.0	COG0425@1|root,COG0425@2|Bacteria,1MZA5@1224|Proteobacteria,42VCF@68525|delta/epsilon subdivisions,2WRI6@28221|Deltaproteobacteria,2ME7G@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	Belongs to the sulfur carrier protein TusA family	-	-	-	ko:K04085	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	TusA
k141_1072_2	596151.DesfrDRAFT_1897	1.74e-76	230.0	COG1908@1|root,COG1908@2|Bacteria,1NUHP@1224|Proteobacteria,42ZKK@68525|delta/epsilon subdivisions,2WUW1@28221|Deltaproteobacteria,2MEX4@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM methyl-viologen-reducing hydrogenase delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	FlpD
k141_1793_1	1382356.JQMP01000003_gene2155	0.000257	48.9	COG0006@1|root,COG0006@2|Bacteria,2G5J8@200795|Chloroflexi,27Z3N@189775|Thermomicrobia	189775|Thermomicrobia	E	Metallopeptidase family M24	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M24
k141_1880_1	1348663.KCH_66960	1.2e-18	90.1	COG1131@1|root,COG1131@2|Bacteria,2GKI7@201174|Actinobacteria,2M25W@2063|Kitasatospora	201174|Actinobacteria	V	Domain of unknown function (DUF4162)	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
k141_1439_1	1218084.BBJK01000131_gene7150	0.000264	50.1	COG0477@1|root,COG2814@2|Bacteria,1QTX0@1224|Proteobacteria,2VHUR@28216|Betaproteobacteria,1K0SD@119060|Burkholderiaceae	28216|Betaproteobacteria	EGP	Major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
k141_1616_1	45351.EDO37095	6.77e-33	125.0	COG0179@1|root,KOG1535@2759|Eukaryota,38DXI@33154|Opisthokonta,3BCS8@33208|Metazoa	33208|Metazoa	Q	hydrolase activity	FAHD2A	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
k141_2599_1	272624.lpg1269	1e-07	60.5	COG0553@1|root,COG0553@2|Bacteria,1NZWA@1224|Proteobacteria,1ST1F@1236|Gammaproteobacteria,1JEDK@118969|Legionellales	118969|Legionellales	KL	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair	-	-	-	-	-	-	-	-	-	-	-	-	DUF4379
k141_250_1	999630.TUZN_1974	7.25e-05	47.0	COG0522@1|root,arCOG04239@2157|Archaea,2XQCT@28889|Crenarchaeota	28889|Crenarchaeota	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rps4	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
k141_250_2	410358.Mlab_1247	7.79e-31	114.0	COG0099@1|root,arCOG01722@2157|Archaea,2XWHE@28890|Euryarchaeota,2N9RA@224756|Methanomicrobia	224756|Methanomicrobia	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rps13	-	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
k141_2242_1	7425.NV12337-PA	2.12e-54	193.0	COG0458@1|root,KOG0370@2759|Eukaryota,38CAC@33154|Opisthokonta,3B9FF@33208|Metazoa,3CS9A@33213|Bilateria,41U31@6656|Arthropoda,3SJKC@50557|Insecta,46DQT@7399|Hymenoptera	33208|Metazoa	F	Carbamoyl-phosphate synthase small chain, CPSase domain	CAD	GO:0000050,GO:0000052,GO:0000166,GO:0001882,GO:0001884,GO:0002119,GO:0002134,GO:0002164,GO:0003674,GO:0003824,GO:0004070,GO:0004087,GO:0004088,GO:0004151,GO:0004672,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006082,GO:0006139,GO:0006206,GO:0006207,GO:0006213,GO:0006220,GO:0006221,GO:0006228,GO:0006464,GO:0006468,GO:0006520,GO:0006525,GO:0006526,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007275,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009605,GO:0009653,GO:0009719,GO:0009725,GO:0009791,GO:0009887,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0016053,GO:0016301,GO:0016310,GO:0016363,GO:0016597,GO:0016740,GO:0016741,GO:0016743,GO:0016772,GO:0016773,GO:0016787,GO:0016810,GO:0016812,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0017144,GO:0018107,GO:0018130,GO:0018193,GO:0018210,GO:0019103,GO:0019240,GO:0019438,GO:0019538,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0019899,GO:0022612,GO:0030424,GO:0030554,GO:0031406,GO:0031667,GO:0031974,GO:0031981,GO:0032501,GO:0032502,GO:0032549,GO:0032551,GO:0032553,GO:0032555,GO:0032557,GO:0032559,GO:0032868,GO:0032991,GO:0033267,GO:0034399,GO:0034404,GO:0034641,GO:0034654,GO:0035295,GO:0035639,GO:0036094,GO:0036211,GO:0036477,GO:0042221,GO:0042455,GO:0042594,GO:0042802,GO:0042995,GO:0043005,GO:0043025,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043195,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043434,GO:0043436,GO:0043603,GO:0043604,GO:0043679,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0044297,GO:0044306,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044456,GO:0044463,GO:0044464,GO:0045202,GO:0046051,GO:0046112,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046394,GO:0046483,GO:0046777,GO:0046872,GO:0046914,GO:0048513,GO:0048565,GO:0048731,GO:0048732,GO:0048856,GO:0050896,GO:0055086,GO:0055123,GO:0060465,GO:0070013,GO:0070335,GO:0070406,GO:0071704,GO:0071941,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:0097458,GO:0098793,GO:0120025,GO:0120038,GO:0140096,GO:0150034,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901652,GO:1901657,GO:1901659,GO:1901698,GO:1901700,GO:1905905	2.1.3.2,3.5.2.3,6.3.5.5	ko:K11540	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R01397,R01993,R10948,R10949	RC00002,RC00010,RC00043,RC00064,RC00632,RC02750,RC02798,RC02850,RC03314	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	Amidohydro_1,CPSase_L_D2,CPSase_L_D3,CPSase_sm_chain,GATase,MGS,OTCace,OTCace_N
k141_2699_1	530564.Psta_2468	9.04e-16	77.8	COG0602@1|root,COG0602@2|Bacteria,2IYXV@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	-	4.3.99.3	ko:K10026	ko00790,ko01100,map00790,map01100	-	R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	-	Fer4_14,Radical_SAM
k141_251_1	604354.TSIB_1321	1.22e-54	193.0	COG0058@1|root,arCOG01421@2157|Archaea,2XV8J@28890|Euryarchaeota,243PW@183968|Thermococci	183968|Thermococci	G	Protein of unknown function (DUF3417)	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
k141_1882_1	1046714.AMRX01000008_gene783	2.03e-58	195.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,1RR2W@1236|Gammaproteobacteria,465RW@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	COG3666 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k141_86_1	1121896.JMLU01000052_gene1260	1.32e-45	162.0	2BFD6@1|root,3296M@2|Bacteria,4NQWY@976|Bacteroidetes,1I31C@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_626_2	1158292.JPOE01000005_gene930	1.13e-55	183.0	COG3335@1|root,COG3335@2|Bacteria,1MW8A@1224|Proteobacteria,2VPNY@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Winged helix-turn helix	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_29,HTH_33
k141_354_1	883.DvMF_2683	1.15e-11	70.5	COG0642@1|root,COG2202@1|root,COG5002@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WIR4@28221|Deltaproteobacteria,2M7T3@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4118,HATPase_c,HisKA,PAS_3,PAS_9,Response_reg
k141_1169_1	933262.AXAM01000021_gene448	3.83e-50	180.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,42NYP@68525|delta/epsilon subdivisions,2WIPJ@28221|Deltaproteobacteria,2MIG6@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Belongs to the peptidase M16 family	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k141_1796_1	997350.HMPREF9129_0146	5.99e-59	199.0	COG3033@1|root,COG3033@2|Bacteria,1TRGV@1239|Firmicutes,248WC@186801|Clostridia,22GQQ@1570339|Peptoniphilaceae	186801|Clostridia	E	Beta-eliminating lyase	tnaA	-	4.1.99.1	ko:K01667	ko00380,map00380	-	R00673	RC00209,RC00355	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
k141_987_1	1163617.SCD_n00144	5.82e-07	50.1	COG1553@1|root,COG1553@2|Bacteria,1RDFR@1224|Proteobacteria,2VSFK@28216|Betaproteobacteria	28216|Betaproteobacteria	P	DsrE family	-	-	-	ko:K06039	-	-	-	-	ko00000	-	-	-	DrsE
k141_987_2	426368.MmarC7_1310	1.29e-12	63.9	COG0425@1|root,arCOG02062@2157|Archaea,2Y0J1@28890|Euryarchaeota,23R7Y@183939|Methanococci	183939|Methanococci	O	PFAM SirA family protein	-	GO:0008150,GO:0009987,GO:0019725,GO:0042592,GO:0048878,GO:0055082,GO:0065007,GO:0065008	-	ko:K04085	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	TusA
k141_253_1	2850.Phatr37403	1.15e-70	213.0	2BG5J@1|root,2S18N@2759|Eukaryota,2XHTV@2836|Bacillariophyta	2836|Bacillariophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_1074_1	2880.D7FJK6	1.81e-55	199.0	COG1372@1|root,2QRRC@2759|Eukaryota	2759|Eukaryota	L	reductase	-	GO:0003674,GO:0003824,GO:0004748,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009141,GO:0009142,GO:0009987,GO:0016491,GO:0016725,GO:0016728,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0055086,GO:0055114,GO:0061731,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576	-	-	-	-	-	-	-	-	-	-	Ribonuc_red_lgC
k141_87_1	349741.Amuc_1819	2.42e-16	84.7	28I8X@1|root,2Z8BQ@2|Bacteria,46V28@74201|Verrucomicrobia,2IVQE@203494|Verrucomicrobiae	203494|Verrucomicrobiae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_1346_1	290402.Cbei_2853	1.13e-08	63.2	COG0477@1|root,COG2814@2|Bacteria,1TRDJ@1239|Firmicutes,247N6@186801|Clostridia,36EU0@31979|Clostridiaceae	186801|Clostridia	EGP	Major facilitator superfamily	-	-	-	ko:K08161	-	-	-	-	ko00000,ko02000	2.A.1.2.20	-	-	MFS_1,Sugar_tr
k141_1884_1	237368.SCABRO_01630	5.88e-49	162.0	COG1403@1|root,COG1403@2|Bacteria	2|Bacteria	V	endonuclease activity	-	-	2.7.7.49	ko:K00986,ko:K07451	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	GIIM,HNH,RVT_1,RVT_N
k141_1075_1	477974.Daud_0695	3.4e-10	63.9	COG0840@1|root,COG3039@1|root,COG0840@2|Bacteria,COG3039@2|Bacteria,1TS6Q@1239|Firmicutes,24B6I@186801|Clostridia,260JJ@186807|Peptococcaceae	186801|Clostridia	L	PFAM Transposase	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k141_2773_1	1382356.JQMP01000004_gene107	2.95e-23	101.0	COG3616@1|root,COG3616@2|Bacteria,2G69D@200795|Chloroflexi,27XSK@189775|Thermomicrobia	189775|Thermomicrobia	E	PFAM alanine racemase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Ala_racemase_N,D-ser_dehydrat
k141_1619_1	641112.ACOK01000114_gene2353	8.24e-62	209.0	COG1148@1|root,COG1148@2|Bacteria,1VPAD@1239|Firmicutes,25B2G@186801|Clostridia,3WGR6@541000|Ruminococcaceae	186801|Clostridia	C	NAD(P)-binding Rossmann-like domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Fer4,Fer4_7,Pyr_redox_2
k141_1247_1	378806.STAUR_3811	6.15e-32	123.0	COG0455@1|root,COG0455@2|Bacteria,1R8IW@1224|Proteobacteria,42R3H@68525|delta/epsilon subdivisions,2WMNY@28221|Deltaproteobacteria,2YUZU@29|Myxococcales	28221|Deltaproteobacteria	D	NUBPL iron-transfer P-loop NTPase	-	-	-	ko:K04562	-	-	-	-	ko00000,ko02035	-	-	-	AAA_31,CbiA,HTH_25,ParA
k141_1797_2	637389.Acaty_c1612	5.25e-24	96.3	COG3436@1|root,COG3436@2|Bacteria,1N7AY@1224|Proteobacteria	1224|Proteobacteria	L	IS66 Orf2 like protein	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	TnpB_IS66
k141_2604_1	1265505.ATUG01000003_gene324	3.74e-22	99.0	COG2768@1|root,COG2768@2|Bacteria,1R08Q@1224|Proteobacteria,43CRC@68525|delta/epsilon subdivisions,2X7YY@28221|Deltaproteobacteria,2MPKX@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
k141_1885_1	453591.Igni_0243	2.54e-148	444.0	COG0086@1|root,arCOG04257@2157|Archaea,2XPT5@28889|Crenarchaeota	28889|Crenarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA1	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03041	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k141_1248_1	1121946.AUAX01000028_gene5900	8.48e-09	62.4	COG0477@1|root,COG2814@2|Bacteria,2IDJ6@201174|Actinobacteria,4D9HF@85008|Micromonosporales	201174|Actinobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k141_2775_1	1121430.JMLG01000006_gene1704	8.93e-44	152.0	COG4887@1|root,COG4887@2|Bacteria,1V4ZU@1239|Firmicutes,24CCD@186801|Clostridia,260FV@186807|Peptococcaceae	186801|Clostridia	S	metal-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1847
k141_1886_1	647113.Metok_0757	7.64e-49	171.0	COG1304@1|root,arCOG00613@2157|Archaea,2XT6H@28890|Euryarchaeota,23QI3@183939|Methanococci	183939|Methanococci	H	Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)	fni	-	5.3.3.2	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123	RC00455	ko00000,ko00001,ko00002,ko01000	-	-	-	FMN_dh
k141_255_1	85681.XP_006424266.1	2.86e-68	224.0	KOG0739@1|root,KOG0739@2759|Eukaryota,37IIW@33090|Viridiplantae,3GBES@35493|Streptophyta	35493|Streptophyta	O	Belongs to the AAA ATPase family	-	GO:0000166,GO:0000902,GO:0000904,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005768,GO:0005770,GO:0005771,GO:0005911,GO:0006629,GO:0006810,GO:0006900,GO:0006914,GO:0006996,GO:0007032,GO:0007033,GO:0007034,GO:0008104,GO:0008144,GO:0008150,GO:0008152,GO:0008202,GO:0009056,GO:0009506,GO:0009653,GO:0009888,GO:0009987,GO:0010008,GO:0010026,GO:0010090,GO:0010091,GO:0010256,GO:0012505,GO:0016020,GO:0016043,GO:0016050,GO:0016125,GO:0016192,GO:0016197,GO:0016236,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022607,GO:0030054,GO:0030154,GO:0030554,GO:0031090,GO:0031410,GO:0031982,GO:0032502,GO:0032507,GO:0032509,GO:0032511,GO:0032553,GO:0032555,GO:0032559,GO:0032989,GO:0032991,GO:0033036,GO:0033365,GO:0034067,GO:0034613,GO:0035639,GO:0036094,GO:0036452,GO:0042592,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044422,GO:0044424,GO:0044425,GO:0044433,GO:0044440,GO:0044444,GO:0044446,GO:0044464,GO:0045053,GO:0045185,GO:0045324,GO:0046907,GO:0046983,GO:0048468,GO:0048856,GO:0048869,GO:0048878,GO:0050801,GO:0051179,GO:0051234,GO:0051235,GO:0051259,GO:0051260,GO:0051641,GO:0051649,GO:0051651,GO:0055044,GO:0055065,GO:0055067,GO:0055075,GO:0055078,GO:0055080,GO:0061024,GO:0061919,GO:0065003,GO:0065007,GO:0065008,GO:0070676,GO:0070727,GO:0071704,GO:0071840,GO:0071985,GO:0090558,GO:0090626,GO:0097159,GO:0097367,GO:0097708,GO:0098588,GO:0098771,GO:0098796,GO:0098805,GO:1901265,GO:1901360,GO:1901363,GO:1901615,GO:1902494,GO:1904949,GO:1990621	-	ko:K12196	ko04144,ko04217,map04144,map04217	M00412	-	-	ko00000,ko00001,ko00002,ko04131	-	-	-	AAA,MIT,Vps4_C
k141_359_1	1280953.HOC_15677	1.33e-72	231.0	COG4948@1|root,COG4948@2|Bacteria,1MU8R@1224|Proteobacteria,2TSS4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Belongs to the mandelate racemase muconate lactonizing enzyme family	-	-	5.1.1.20,5.5.1.1	ko:K01856,ko:K19802	ko00361,ko00362,ko00364,ko00623,ko01100,ko01120,ko01220,map00361,map00362,map00364,map00623,map01100,map01120,map01220	M00568	R05300,R05390,R06989,R08116,R09229,R10938	RC00903,RC01038,RC01108,RC01321,RC01356,RC03309	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
k141_256_1	1151117.AJLF01000001_gene1484	2.43e-49	170.0	COG2516@1|root,arCOG00662@2157|Archaea,2Y23P@28890|Euryarchaeota,242IG@183968|Thermococci	183968|Thermococci	S	Elongator protein 3, MiaB family, Radical SAM	-	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
k141_1897_1	1347087.CBYO010000017_gene2764	1.18e-55	187.0	COG2008@1|root,COG2008@2|Bacteria,1TPZI@1239|Firmicutes,4HAM3@91061|Bacilli	91061|Bacilli	E	Threonine aldolase	-	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
k141_12_1	1121405.dsmv_0564	1.74e-83	276.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MXBU@1224|Proteobacteria,42M59@68525|delta/epsilon subdivisions,2WIUK@28221|Deltaproteobacteria,2MICN@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Pyruvate phosphate dikinase, PEP	-	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
k141_2618_1	913865.DOT_0120	4.74e-61	211.0	COG2414@1|root,COG2414@2|Bacteria,1UZ61@1239|Firmicutes,24BSS@186801|Clostridia,263SW@186807|Peptococcaceae	186801|Clostridia	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
k141_455_1	515635.Dtur_0260	1.22e-10	65.1	COG1014@1|root,COG1014@2|Bacteria	2|Bacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	porC	-	1.2.7.1	ko:K00172	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
k141_188_2	880073.Calab_0434	1.51e-21	94.0	COG1670@1|root,COG1670@2|Bacteria,2NPXX@2323|unclassified Bacteria	2|Bacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
k141_2078_1	279530.Q4L1F2_9CAUD	2.17e-39	149.0	4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses  no RNA stage,4QPQ9@28883|Caudovirales,4QI9F@10662|Myoviridae	10662|Myoviridae	S	Type III restriction enzyme, res subunit	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_2264_1	1236689.MMALV_09390	3.16e-60	209.0	COG4231@1|root,arCOG01609@2157|Archaea,2XUNR@28890|Euryarchaeota,3F2HQ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,Fer4_7,POR_N,TPP_enzyme_C
k141_2172_1	9483.ENSCJAP00000051323	2.91e-16	83.2	COG1111@1|root,KOG0354@2759|Eukaryota,390WH@33154|Opisthokonta,3BECR@33208|Metazoa,3D1X4@33213|Bilateria,48BJP@7711|Chordata,48VMY@7742|Vertebrata,3J3AJ@40674|Mammalia,35KNE@314146|Euarchontoglires,4MAKJ@9443|Primates	33208|Metazoa	A	ATP-dependent RNA helicase DHX58	DHX58	GO:0001817,GO:0001818,GO:0001819,GO:0002682,GO:0002683,GO:0002684,GO:0002697,GO:0002698,GO:0002699,GO:0002831,GO:0002832,GO:0002833,GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003727,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008270,GO:0009605,GO:0009607,GO:0009615,GO:0009617,GO:0009966,GO:0009967,GO:0009968,GO:0010646,GO:0010647,GO:0010648,GO:0023051,GO:0023056,GO:0023057,GO:0031347,GO:0031348,GO:0031349,GO:0032101,GO:0032102,GO:0032103,GO:0032479,GO:0032480,GO:0032481,GO:0039531,GO:0039532,GO:0039533,GO:0039534,GO:0039535,GO:0039536,GO:0043167,GO:0043169,GO:0043207,GO:0043900,GO:0043901,GO:0043902,GO:0044424,GO:0044464,GO:0045088,GO:0045089,GO:0045824,GO:0046872,GO:0046914,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048584,GO:0048585,GO:0050687,GO:0050688,GO:0050776,GO:0050777,GO:0050778,GO:0050789,GO:0050794,GO:0050896,GO:0051239,GO:0051240,GO:0051241,GO:0051704,GO:0051707,GO:0065007,GO:0080134,GO:0097159,GO:1900245,GO:1900246,GO:1901363,GO:1902531,GO:1902532,GO:1902533	3.6.3.14	ko:K12649	ko04622,map04622	-	-	-	ko00000,ko00001,ko01000	-	-	-	Helicase_C,RIG-I_C-RD,ResIII
k141_2350_1	456442.Mboo_1373	3.22e-49	177.0	COG1152@1|root,arCOG02428@2157|Archaea,2XTBY@28890|Euryarchaeota,2N9CY@224756|Methanomicrobia	224756|Methanomicrobia	C	Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase	cdhA	-	1.2.7.4	ko:K00192	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00422	R07157	RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_7,Fer4_9,Prismane
k141_2439_1	338966.Ppro_1192	6.3e-05	48.5	COG0535@1|root,COG0535@2|Bacteria,1MXM1@1224|Proteobacteria,42PCW@68525|delta/epsilon subdivisions,2WMDU@28221|Deltaproteobacteria,43UIR@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Domain of unknown function (DUF3463)	hpnH	-	-	-	-	-	-	-	-	-	-	-	DUF3463,Fer4_12,Fer4_14,Radical_SAM
k141_1898_1	1347392.CCEZ01000075_gene3005	1.78e-143	418.0	COG0274@1|root,COG0274@2|Bacteria,1TPA0@1239|Firmicutes,249YN@186801|Clostridia,36F7D@31979|Clostridiaceae	186801|Clostridia	F	D-Lysine 5,6-aminomutase TIM-barrel domain of alpha subunit	kamD	-	5.4.3.3	ko:K01844	ko00310,map00310	-	R02852,R03275	RC00719	ko00000,ko00001,ko01000	-	-	-	Lys-AminoMut_A
k141_2440_1	1121472.AQWN01000007_gene1046	3.32e-38	142.0	COG1454@1|root,COG1454@2|Bacteria,1V1AD@1239|Firmicutes,24ED6@186801|Clostridia	186801|Clostridia	C	Iron-containing alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Fe-ADH
k141_1267_1	697281.Mahau_2697	4.84e-79	246.0	COG0407@1|root,COG0407@2|Bacteria,1V4YU@1239|Firmicutes,24FCZ@186801|Clostridia,42HY1@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
k141_2173_1	1327977.R9ZXS6_9CAUD	9.15e-14	74.7	4QE8A@10239|Viruses,4QXTV@35237|dsDNA viruses  no RNA stage,4QS6D@28883|Caudovirales,4QNZR@10744|Podoviridae	10744|Podoviridae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_2079_1	44689.DDB0215265	3.32e-06	53.9	290ZG@1|root,2R7V2@2759|Eukaryota,3XENA@554915|Amoebozoa	554915|Amoebozoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_370_1	159749.K0RL60	2.04e-135	428.0	COG2801@1|root,2QT1S@2759|Eukaryota	2759|Eukaryota	L	transposition	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1,rve
k141_1268_1	591158.SSMG_05869	4.7e-19	89.7	COG0714@1|root,COG0714@2|Bacteria,2GMBP@201174|Actinobacteria	201174|Actinobacteria	S	PFAM ATPase associated with various cellular activities, AAA_5	-	-	-	-	-	-	-	-	-	-	-	-	AAA_5,VWA_CoxE
k141_909_1	1071073.KI530537_gene1312	1.76e-21	95.5	COG1349@1|root,COG1349@2|Bacteria,1TSF8@1239|Firmicutes,4HDT9@91061|Bacilli,1ZBIR@1386|Bacillus	91061|Bacilli	K	Transcriptional regulator	fruR	-	-	ko:K03436	-	-	-	-	ko00000,ko03000	-	-	-	DeoRC,HTH_DeoR
k141_1364_1	1122172.KB890260_gene1944	2.22e-19	96.3	COG1882@1|root,COG1882@2|Bacteria,378BD@32066|Fusobacteria	32066|Fusobacteria	C	formate C-acetyltransferase	-	-	2.3.1.54	ko:K00656	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
k141_2800_1	1220534.B655_1938	2.06e-73	228.0	COG1029@1|root,arCOG01499@2157|Archaea,2XTPW@28890|Euryarchaeota,23PCR@183925|Methanobacteria	183925|Methanobacteria	C	Formylmethanofuran dehydrogenase, subunit B	fwdB	-	1.2.7.12	ko:K00201	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Molybdopterin
k141_1721_1	1297617.JPJD01000049_gene1306	5.91e-07	59.7	COG5283@1|root,COG5283@2|Bacteria,1UVPX@1239|Firmicutes,25P02@186801|Clostridia,26A1X@186813|unclassified Clostridiales	186801|Clostridia	S	Phage-related minor tail protein	-	-	-	-	-	-	-	-	-	-	-	-	PhageMin_Tail
k141_819_1	112098.XP_008603703.1	2.33e-11	70.1	COG1100@1|root,KOG0087@2759|Eukaryota	2759|Eukaryota	J	GTPase activity	-	-	-	ko:K07874,ko:K07904	ko04144,ko04961,ko04962,ko04972,ko05134,map04144,map04961,map04962,map04972,map05134	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	GCK,Ras
k141_2529_1	221360.RS9917_00612	7.51e-50	178.0	COG2801@1|root,COG2801@2|Bacteria,1G5RM@1117|Cyanobacteria,1GZMX@1129|Synechococcus	1117|Cyanobacteria	L	Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,rve
k141_1997_1	891391.LAC30SC_00735	4.51e-09	62.4	COG3666@1|root,COG3666@2|Bacteria,1TQQ9@1239|Firmicutes,4H9KK@91061|Bacilli,3F4M8@33958|Lactobacillaceae	91061|Bacilli	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k141_457_1	186497.PF1734	1.42e-07	55.1	COG1522@1|root,arCOG01580@2157|Archaea,2XWJA@28890|Euryarchaeota,243ZM@183968|Thermococci	183968|Thermococci	K	transcription regulator activity	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24
k141_1457_1	913865.DOT_3301	9.81e-82	259.0	COG0517@1|root,COG0517@2|Bacteria,1TQ4J@1239|Firmicutes,24B68@186801|Clostridia,260BK@186807|Peptococcaceae	186801|Clostridia	S	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
k141_2443_2	589865.DaAHT2_2589	6.81e-32	124.0	COG3385@1|root,COG3385@2|Bacteria,1R8CS@1224|Proteobacteria,42P9F@68525|delta/epsilon subdivisions,2WKTA@28221|Deltaproteobacteria,2MJAY@213118|Desulfobacterales	28221|Deltaproteobacteria	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5,DDE_Tnp_2
k141_1092_1	370438.PTH_1544	7.42e-82	251.0	COG0714@1|root,COG0714@2|Bacteria,1TRSV@1239|Firmicutes,24ARU@186801|Clostridia,260I4@186807|Peptococcaceae	186801|Clostridia	O	PFAM ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_5
k141_306_1	96561.Dole_3272	1.52e-24	110.0	COG0784@1|root,COG2202@1|root,COG3437@1|root,COG3829@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG3437@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42M1R@68525|delta/epsilon subdivisions,2WK3J@28221|Deltaproteobacteria,2MI5F@213118|Desulfobacterales	28221|Deltaproteobacteria	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,SBP_bac_3
k141_41_1	401053.AciPR4_0532	8.04e-08	59.3	COG0312@1|root,COG0312@2|Bacteria,3Y39N@57723|Acidobacteria,2JIHC@204432|Acidobacteriia	204432|Acidobacteriia	S	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
k141_860_1	635013.TherJR_0790	2.65e-50	176.0	COG0012@1|root,COG0012@2|Bacteria,1UIBA@1239|Firmicutes,24DM9@186801|Clostridia	186801|Clostridia	J	GTP binding	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_2555_1	698737.SLGD_01050	1.67e-60	200.0	COG2309@1|root,COG2309@2|Bacteria,1TP65@1239|Firmicutes,4H9W8@91061|Bacilli,4GX5R@90964|Staphylococcaceae	91061|Bacilli	E	COG2309 Leucyl aminopeptidase (aminopeptidase T)	pepS	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
k141_2028_1	159749.K0T6C5	1.25e-58	212.0	COG2801@1|root,KOG0017@2759|Eukaryota,2XF4I@2836|Bacillariophyta	159749.K0T6C5|-	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_1301_1	929556.Solca_0050	3.04e-23	103.0	COG1470@1|root,COG3209@1|root,COG4932@1|root,COG1470@2|Bacteria,COG3209@2|Bacteria,COG4932@2|Bacteria,4PKBQ@976|Bacteroidetes,1J0N1@117747|Sphingobacteriia	976|Bacteroidetes	M	conserved repeat domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,Calx-beta,DUF11,SprB
k141_1127_1	323259.Mhun_2282	5.32e-19	84.3	COG0638@1|root,arCOG00971@2157|Archaea,2XUKA@28890|Euryarchaeota,2N98W@224756|Methanomicrobia	224756|Methanomicrobia	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmA	GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019773,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome,Proteasome_A_N
k141_2337_2	694429.Pyrfu_0929	8.15e-25	95.9	COG2053@1|root,arCOG04314@2157|Archaea,2XQTB@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eS28 family	rps28e	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990904	-	ko:K02979	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S28e
k141_444_1	1238184.CM001792_gene1454	5.04e-76	250.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,4HA3S@91061|Bacilli,23IQB@182709|Oceanobacillus	91061|Bacilli	V	ABC transporter transmembrane region	yknU	GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015399,GO:0015405,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0071702	-	ko:K06147,ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k141_1238_1	6669.EFX62075	9.96e-05	43.1	2E8JE@1|root,2SF1C@2759|Eukaryota,3ASDN@33154|Opisthokonta,3C420@33208|Metazoa,3DJAF@33213|Bilateria	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_2338_2	2325.TKV_c10820	2.07e-28	114.0	COG1760@1|root,COG1760@2|Bacteria,1TP79@1239|Firmicutes,2480J@186801|Clostridia,42G2I@68295|Thermoanaerobacterales	186801|Clostridia	E	L-serine dehydratase, iron-sulfur-dependent, alpha subunit	sdaAA	-	4.3.1.17	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230	-	R00220,R00590	RC00331,RC02600	ko00000,ko00001,ko01000	-	-	-	SDH_alpha
k141_1706_1	656519.Halsa_2377	4.18e-60	200.0	COG1003@1|root,COG1003@2|Bacteria,1TPK9@1239|Firmicutes,2480Q@186801|Clostridia,3WB6B@53433|Halanaerobiales	186801|Clostridia	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS11880	Aminotran_5,GDC-P
k141_76_1	946483.Cenrod_1746	2.91e-16	85.9	COG0642@1|root,COG0745@1|root,COG2198@1|root,COG2199@1|root,COG0745@2|Bacteria,COG2198@2|Bacteria,COG2205@2|Bacteria,COG3706@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Histidine kinase	bvgS2	-	-	ko:K14978	ko02020,map02020	M00663	-	-	ko00000,ko00001,ko00002,ko01001,ko02022	-	-	-	HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_7,Response_reg
k141_979_1	871963.Desdi_1898	1.38e-17	90.1	COG0644@1|root,COG0644@2|Bacteria,1TRRU@1239|Firmicutes,2481K@186801|Clostridia,2604Q@186807|Peptococcaceae	186801|Clostridia	C	Oxidoreductase	fixC	-	-	ko:K00313	-	-	-	-	ko00000,ko01000	-	-	-	DAO,FAD_binding_2,FAD_oxidored,Pyr_redox_2,Thi4
k141_618_1	522772.Dacet_0663	1.08e-87	270.0	COG3328@1|root,COG3328@2|Bacteria,2GGBW@200930|Deferribacteres	200930|Deferribacteres	L	PFAM transposase mutator type	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k141_1239_1	273063.STK_23450	2.15e-18	89.4	COG0519@1|root,arCOG00085@2157|Archaea,2XPVC@28889|Crenarchaeota	28889|Crenarchaeota	F	GMP synthase, glutamine-hydrolyzing	guaA	GO:0000162,GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042401,GO:0042430,GO:0042435,GO:0042451,GO:0042455,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046129,GO:0046219,GO:0046390,GO:0046394,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901657,GO:1901659,GO:1902494	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
k141_343_1	936053.I1BMX3	1.57e-25	109.0	COG1070@1|root,KOG2531@2759|Eukaryota,38EEF@33154|Opisthokonta,3NUTT@4751|Fungi,1GT7F@112252|Fungi incertae sedis	4751|Fungi	G	FGGY family of carbohydrate kinases, N-terminal domain	xkiA	GO:0003674,GO:0003824,GO:0004856,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005996,GO:0005997,GO:0005998,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019321,GO:0019323,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046365,GO:0046835,GO:0071704,GO:1901575	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
k141_2766_1	269797.Mbar_A1054	2.54e-12	73.9	COG0407@1|root,arCOG03324@2157|Archaea,2XVT1@28890|Euryarchaeota,2NA2I@224756|Methanomicrobia	224756|Methanomicrobia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	2.1.1.246	ko:K14080	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00356	R09098,R10000	RC00035,RC01144,RC02440	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A1054	URO-D
k141_619_1	760568.Desku_1633	1.29e-81	250.0	COG1402@1|root,COG1402@2|Bacteria,1V0N8@1239|Firmicutes,24BWG@186801|Clostridia,26725@186807|Peptococcaceae	186801|Clostridia	S	Creatinine amidohydrolase	-	-	3.5.2.10	ko:K01470,ko:K22232	ko00330,ko00562,map00330,map00562	-	R01884,R11771	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
k141_1434_1	349163.Acry_0967	3.3e-23	99.8	COG2761@1|root,COG2761@2|Bacteria,1NXUB@1224|Proteobacteria,2TRJ6@28211|Alphaproteobacteria,2JS92@204441|Rhodospirillales	204441|Rhodospirillales	Q	dithiol-disulfide isomerase involved in polyketide biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
k141_1068_1	1047013.AQSP01000140_gene2486	1.84e-22	91.3	COG1051@1|root,COG1051@2|Bacteria,2NPYB@2323|unclassified Bacteria	2|Bacteria	F	NUDIX domain	-	-	1.1.1.169,3.1.3.25,3.6.1.55	ko:K00077,ko:K01092,ko:K03574	ko00521,ko00562,ko00770,ko01100,ko01110,ko04070,map00521,map00562,map00770,map01100,map01110,map04070	M00119,M00131	R01185,R01186,R01187,R02472	RC00078,RC00726	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	NUDIX
k141_345_1	96561.Dole_2313	4.41e-76	243.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42MEA@68525|delta/epsilon subdivisions,2WIW6@28221|Deltaproteobacteria,2MI74@213118|Desulfobacterales	28221|Deltaproteobacteria	KT	Sigma-54 interaction domain	-	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	HTH_8,PAS_4,PAS_9,Sigma54_activat
k141_1340_1	385682.AFSL01000040_gene233	1.77e-66	226.0	COG1472@1|root,COG1472@2|Bacteria,4NE90@976|Bacteroidetes,2FMV4@200643|Bacteroidia,3XM1Y@558415|Marinilabiliaceae	976|Bacteroidetes	G	PA14	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C,PA14
k141_1709_2	555779.Dthio_PD0024	0.0003	41.2	COG3436@1|root,COG3436@2|Bacteria,1N638@1224|Proteobacteria,430NK@68525|delta/epsilon subdivisions,2WVZ0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM IS66 Orf2 family protein	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	TnpB_IS66
k141_2238_1	877455.Metbo_1366	3.95e-123	370.0	COG0017@1|root,arCOG00406@2157|Archaea,2XTRE@28890|Euryarchaeota,23NJ0@183925|Methanobacteria	183925|Methanobacteria	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.23	ko:K09759	ko00970,map00970	M00360	R03647,R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
k141_2150_1	1305737.JAFX01000001_gene2506	1.7e-81	259.0	COG3547@1|root,COG3547@2|Bacteria,4NHYP@976|Bacteroidetes	976|Bacteroidetes	L	PFAM Transposase IS116 IS110 IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k141_1242_1	1242864.D187_005577	1.92e-06	56.2	COG0402@1|root,COG5184@1|root,COG0402@2|Bacteria,COG5184@2|Bacteria,1R504@1224|Proteobacteria,42QHC@68525|delta/epsilon subdivisions,2WKUI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	DZ	Alpha-tubulin suppressor and related RCC1 domain-containing proteins	-	-	-	-	-	-	-	-	-	-	-	-	RCC1
k141_621_1	903814.ELI_0486	1.16e-05	50.1	COG5598@1|root,COG5598@2|Bacteria,1UY21@1239|Firmicutes,248BQ@186801|Clostridia	186801|Clostridia	H	PFAM Trimethylamine methyltransferase (MTTB)	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
k141_621_2	1382356.JQMP01000003_gene2153	4.49e-33	124.0	COG2120@1|root,COG2120@2|Bacteria,2G6FB@200795|Chloroflexi,27XV7@189775|Thermomicrobia	189775|Thermomicrobia	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
k141_79_1	1487921.DP68_15385	2.77e-31	120.0	COG0801@1|root,COG1539@1|root,COG0801@2|Bacteria,COG1539@2|Bacteria,1V6PR@1239|Firmicutes,249YP@186801|Clostridia,36ECT@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin	folK	-	2.7.6.3,4.1.2.25	ko:K00950,ko:K13940	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503,R03504	RC00002,RC00017,RC00721,RC00943	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB,HPPK
k141_347_1	138119.DSY3156	2.27e-23	103.0	COG5598@1|root,COG5598@2|Bacteria,1UY21@1239|Firmicutes,248BQ@186801|Clostridia,260DN@186807|Peptococcaceae	186801|Clostridia	H	PFAM Trimethylamine methyltransferase (MTTB)	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
k141_1341_1	406327.Mevan_0068	7e-69	229.0	COG1148@1|root,arCOG02235@2157|Archaea,2XT3X@28890|Euryarchaeota,23QA9@183939|Methanococci	183939|Methanococci	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Pyr_redox_2
k141_1614_1	1414766.A0A0A0P0H4_9VIRU	4.94e-71	236.0	4QFZG@10239|Viruses	10239|Viruses	S	Phage terminase large subunit	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_248_1	401526.TcarDRAFT_1293	4.76e-15	87.8	COG0503@1|root,COG0741@1|root,COG0503@2|Bacteria,COG0741@2|Bacteria,1TSYQ@1239|Firmicutes,4H5A6@909932|Negativicutes	909932|Negativicutes	F	protein secretion by the type IV secretion system	-	-	-	-	-	-	-	-	-	-	-	-	SLT
k141_2239_1	439235.Dalk_1689	2.56e-77	257.0	COG2202@1|root,COG2204@1|root,COG4191@1|root,COG2202@2|Bacteria,COG2204@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MFW@68525|delta/epsilon subdivisions,2WKMP@28221|Deltaproteobacteria,2MI6S@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,Response_reg
k141_536_1	679190.HMPREF0650_0947	3.58e-33	131.0	COG3039@1|root,COG3039@2|Bacteria,4NJTB@976|Bacteroidetes,2FQ6H@200643|Bacteroidia	976|Bacteroidetes	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
k141_1071_1	263820.PTO0875	5.55e-33	123.0	COG1632@1|root,arCOG04209@2157|Archaea,2XTJJ@28890|Euryarchaeota,241PP@183967|Thermoplasmata	183967|Thermoplasmata	J	structural constituent of ribosome	rpl15e	-	-	ko:K02877	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L15e
k141_1792_1	1521187.JPIM01000068_gene744	2.86e-35	132.0	COG1131@1|root,COG1131@2|Bacteria,2G6HA@200795|Chloroflexi,376NC@32061|Chloroflexia	32061|Chloroflexia	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
k141_983_1	247490.KSU1_B0160	1.68e-58	201.0	COG1222@1|root,COG1222@2|Bacteria,2J2BA@203682|Planctomycetes	203682|Planctomycetes	O	Cell division protein 48 (CDC48) domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N
k141_110_1	272569.rrnAC2565	9.79e-67	215.0	COG0470@1|root,arCOG00469@2157|Archaea,2XTC8@28890|Euryarchaeota,23SFU@183963|Halobacteria	183963|Halobacteria	L	Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA	rfc	-	-	ko:K04801	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA,DNA_pol3_delta2,Intein_splicing,LAGLIDADG_3,Rep_fac_C,RuvB_N
k141_1910_1	525318.HMPREF0497_2600	8.59e-07	53.1	COG0452@1|root,COG0452@2|Bacteria,1TPP3@1239|Firmicutes,4HAK8@91061|Bacilli,3F3XX@33958|Lactobacillaceae	91061|Bacilli	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K01598,ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
k141_2181_1	1499967.BAYZ01000181_gene4483	1.05e-82	258.0	COG0148@1|root,COG0148@2|Bacteria,2NNKW@2323|unclassified Bacteria	2|Bacteria	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	GO:0001968,GO:0003674,GO:0003824,GO:0004634,GO:0005488,GO:0005515,GO:0005518,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0019899,GO:0030312,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035375,GO:0042866,GO:0043236,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0044877,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0050840,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
k141_379_1	287986.DV20_36335	9.21e-28	114.0	COG0045@1|root,COG0045@2|Bacteria,2GKSB@201174|Actinobacteria,4E03D@85010|Pseudonocardiales	201174|Actinobacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
k141_1100_3	573370.DMR_45150	6.63e-07	55.8	COG3728@1|root,COG3728@2|Bacteria,1NEAA@1224|Proteobacteria,43B89@68525|delta/epsilon subdivisions,2X6MN@28221|Deltaproteobacteria,2MH4J@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	Terminase small subunit	-	-	-	ko:K07474	-	-	-	-	ko00000	-	-	-	Terminase_2
k141_1100_4	1408428.JNJP01000030_gene963	7.4e-104	322.0	COG5323@1|root,COG5323@2|Bacteria,1R049@1224|Proteobacteria,42UYF@68525|delta/epsilon subdivisions,2WQN3@28221|Deltaproteobacteria,2M90K@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Terminase RNaseH-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_6
k141_1304_1	1322246.BN4_20026	6.49e-41	145.0	2AHDX@1|root,317QZ@2|Bacteria,1PZ3K@1224|Proteobacteria,435PH@68525|delta/epsilon subdivisions,2X9BN@28221|Deltaproteobacteria,2MA8H@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_2560_2	221288.JH992901_gene1040	1.29e-11	66.2	COG2405@1|root,COG2405@2|Bacteria,1GJUX@1117|Cyanobacteria,1JJRP@1189|Stigonemataceae	1117|Cyanobacteria	S	Domain of unknown function (DUF3368)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3368
k141_1506_1	69319.XP_008558880.1	8.22e-11	64.7	KOG1075@1|root,KOG1075@2759|Eukaryota,3AQ0C@33154|Opisthokonta,3C2M2@33208|Metazoa,3DIDC@33213|Bilateria,422YU@6656|Arthropoda,3SRPW@50557|Insecta	33208|Metazoa	S	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2
k141_1130_1	13735.ENSPSIP00000007376	2.95e-11	63.2	2DZNV@1|root,2S761@2759|Eukaryota,3AC9Y@33154|Opisthokonta,3BWFX@33208|Metazoa,3DCDA@33213|Bilateria,48H0Z@7711|Chordata,49H31@7742|Vertebrata	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_1130_3	10029.XP_007634688.1	4.64e-15	76.6	COG2036@1|root,COG5262@1|root,KOG1745@2759|Eukaryota,KOG1756@2759|Eukaryota,39ZTV@33154|Opisthokonta,3BPDH@33208|Metazoa,3D6BK@33213|Bilateria,48E1W@7711|Chordata,49B7M@7742|Vertebrata,3JGKY@40674|Mammalia,35PSM@314146|Euarchontoglires,4Q54X@9989|Rodentia	33208|Metazoa	B	Core histone H2A/H2B/H3/H4	HIST3H3	GO:0000228,GO:0000723,GO:0000726,GO:0000785,GO:0000786,GO:0000788,GO:0000790,GO:0003674,GO:0003676,GO:0003677,GO:0003682,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005694,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006303,GO:0006323,GO:0006325,GO:0006333,GO:0006334,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016233,GO:0022607,GO:0031333,GO:0031490,GO:0031491,GO:0031492,GO:0031497,GO:0031974,GO:0031981,GO:0032200,GO:0032459,GO:0032460,GO:0032991,GO:0032993,GO:0033554,GO:0034622,GO:0034641,GO:0034728,GO:0042592,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043254,GO:0043933,GO:0044085,GO:0044087,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044454,GO:0044464,GO:0044815,GO:0044877,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051129,GO:0051259,GO:0051262,GO:0051276,GO:0051290,GO:0051291,GO:0051716,GO:0060249,GO:0065003,GO:0065004,GO:0065007,GO:0065008,GO:0070013,GO:0071103,GO:0071704,GO:0071824,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363	-	ko:K11253,ko:K11275	ko05034,ko05202,ko05322,map05034,map05202,map05322	-	-	-	ko00000,ko00001,ko03036,ko04147	-	-	-	Histone
k141_1305_1	864069.MicloDRAFT_00005480	2.84e-82	255.0	COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,2TUQT@28211|Alphaproteobacteria,1JRXN@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	PFAM transposase mutator type	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k141_773_2	5911.EAR85334	2.1e-20	89.7	COG1100@1|root,KOG0087@2759|Eukaryota,3ZDVJ@5878|Ciliophora	5878|Ciliophora	U	Rab subfamily of small GTPases	-	-	-	ko:K07904	ko04144,ko04961,ko04962,ko04972,map04144,map04961,map04962,map04972	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
k141_1397_1	67275.JOAP01000059_gene1558	2.38e-38	147.0	COG3250@1|root,COG3250@2|Bacteria,2GMAT@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 2 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N,PA14
k141_2204_1	264732.Moth_2216	6.22e-12	65.1	2DMSV@1|root,32TFU@2|Bacteria,1VC0G@1239|Firmicutes,24Q3V@186801|Clostridia,42IQ0@68295|Thermoanaerobacterales	186801|Clostridia	S	DGC domain	-	-	-	-	-	-	-	-	-	-	-	-	DGC
k141_2204_2	945713.IALB_2836	5.02e-09	57.4	COG1146@1|root,COG1146@2|Bacteria	2|Bacteria	C	4 iron, 4 sulfur cluster binding	fdxB	-	1.17.1.1,1.2.7.3	ko:K00176,ko:K00523	ko00020,ko00520,ko00720,ko01100,ko01120,ko01200,map00020,map00520,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197,R03391,R03392	RC00004,RC00230,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_21,Fer4_4,Fer4_6,Fer4_7
k141_866_1	1094980.Mpsy_0847	2.25e-09	63.5	COG0531@1|root,arCOG00009@2157|Archaea,2XTX6@28890|Euryarchaeota,2NA79@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM amino acid permease-associated region	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2,Usp
k141_1574_1	1005048.CFU_3609	6.33e-27	108.0	COG1702@1|root,COG1702@2|Bacteria,1MVDV@1224|Proteobacteria,2VH9V@28216|Betaproteobacteria,4737E@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	Phosphate starvation-inducible protein	ybeZ	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
k141_2561_1	70448.Q00SW9	3.04e-08	60.1	COG0709@1|root,KOG3939@2759|Eukaryota,37W4Y@33090|Viridiplantae,34IA6@3041|Chlorophyta	3041|Chlorophyta	T	Selenide, water dikinase	SELD	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C,Pyr_redox_2
k141_2302_1	1121422.AUMW01000009_gene3237	2.51e-14	78.6	COG4383@1|root,COG4383@2|Bacteria,1TT9A@1239|Firmicutes,24BZB@186801|Clostridia,264R3@186807|Peptococcaceae	186801|Clostridia	S	COGs COG4383 Mu-like prophage protein gp29	-	-	-	-	-	-	-	-	-	-	-	-	DUF935
k141_583_1	1227487.C474_15509	4.73e-25	108.0	COG1793@1|root,arCOG01347@2157|Archaea,2XTCK@28890|Euryarchaeota,23TTN@183963|Halobacteria	183963|Halobacteria	L	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair	lig	-	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
k141_1668_1	195522.BD01_1826	7.57e-41	154.0	COG1933@1|root,arCOG04447@2157|Archaea,2XU5S@28890|Euryarchaeota,24309@183968|Thermococci	183968|Thermococci	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polC	GO:0003674,GO:0005488,GO:0005515,GO:0042802	2.7.7.7	ko:K02322	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	Intein_splicing,LAGLIDADG_3,PolC_DP2
k141_585_1	289376.THEYE_A1654	7.11e-34	134.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,3J0ZI@40117|Nitrospirae	40117|Nitrospirae	C	ATP-grasp domain	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
k141_2563_1	647113.Metok_1545	1.07e-09	65.5	COG1775@1|root,arCOG04464@2157|Archaea,2XVHY@28890|Euryarchaeota,23QC0@183939|Methanococci	183939|Methanococci	E	PFAM 2-hydroxyglutaryl-CoA dehydratase, D-component	-	-	-	-	-	-	-	-	-	-	-	-	HGD-D
k141_1308_1	2850.Phatrdraft1240	5.34e-52	188.0	COG2801@1|root,KOG0017@2759|Eukaryota,2XEGG@2836|Bacillariophyta	2836|Bacillariophyta	L	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	RVT_2,gag_pre-integrs,rve,zf-CCHC
k141_2305_1	710393.HSUHS1_0899	9.4e-24	106.0	COG0068@1|root,COG0068@2|Bacteria,1MVP8@1224|Proteobacteria,42M3G@68525|delta/epsilon subdivisions,2YM8M@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	O	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
k141_2032_1	877455.Metbo_2222	8.2e-97	298.0	COG1222@1|root,arCOG01306@2157|Archaea,2XTB6@28890|Euryarchaeota,23NMD@183925|Methanobacteria	183925|Methanobacteria	O	ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C- terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates	pan	-	-	ko:K03420	ko03050,map03050	M00343	-	-	ko00000,ko00001,ko00002,ko03051	-	-	-	AAA
k141_494_1	443144.GM21_3239	8.59e-103	307.0	COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,42N8V@68525|delta/epsilon subdivisions,2WJWB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
k141_587_1	371042.NG99_23680	1.43e-05	47.4	COG2189@1|root,COG2189@2|Bacteria,1QUB9@1224|Proteobacteria,1RMSJ@1236|Gammaproteobacteria,3X6F2@551|Erwinia	1236|Gammaproteobacteria	L	DNA methylase	-	-	2.1.1.72	ko:K07319	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
k141_315_2	1458863.A0A088C427_9CAUD	3.4e-47	155.0	4QCCA@10239|Viruses,4QY28@35237|dsDNA viruses  no RNA stage,4QU0Q@28883|Caudovirales,4QJ8G@10662|Myoviridae	10662|Myoviridae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_2033_1	751944.HALDL1_15150	5.78e-32	125.0	COG3276@1|root,arCOG01563@2157|Archaea,2XUKU@28890|Euryarchaeota,23SWR@183963|Halobacteria	183963|Halobacteria	J	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA	eif2g	-	-	ko:K03242	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,eIF2_C
k141_942_1	1304885.AUEY01000004_gene942	8.37e-53	181.0	COG0349@1|root,COG0349@2|Bacteria,1MURV@1224|Proteobacteria,42N0J@68525|delta/epsilon subdivisions,2WJFX@28221|Deltaproteobacteria,2MHNC@213118|Desulfobacterales	28221|Deltaproteobacteria	J	3'-5' exonuclease	rnd	-	3.1.13.5	ko:K03684	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DNA_pol_A_exo1,HRDC
k141_2118_1	1463854.JOHT01000009_gene1422	1.55e-56	187.0	COG2159@1|root,COG2159@2|Bacteria,2GP75@201174|Actinobacteria	201174|Actinobacteria	S	Amidohydrolase	-	-	4.1.1.52	ko:K22213	-	-	-	-	ko00000,ko01000	-	-	-	Amidohydro_2
k141_2564_1	1380600.AUYN01000007_gene3059	9.3e-30	113.0	COG0756@1|root,COG0756@2|Bacteria,4NNI4@976|Bacteroidetes,1I1AC@117743|Flavobacteriia	976|Bacteroidetes	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
k141_408_1	420247.Msm_0626	5.69e-65	214.0	COG0206@1|root,arCOG02201@2157|Archaea,2XTMW@28890|Euryarchaeota,23NJT@183925|Methanobacteria	183925|Methanobacteria	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
k141_775_1	376686.Fjoh_4311	2.1e-42	152.0	COG2152@1|root,COG2152@2|Bacteria,4NG7B@976|Bacteroidetes,1IIR4@117743|Flavobacteriia,2P03I@237|Flavobacterium	976|Bacteroidetes	G	beta-1,4-mannooligosaccharide phosphorylase	-	-	2.4.1.339,2.4.1.340	ko:K20885	-	-	R11397,R11398	RC00049,RC02748	ko00000,ko01000	-	GH130	-	Glyco_hydro_130
k141_1035_1	1379281.AVAG01000024_gene1866	2.84e-20	90.5	COG1148@1|root,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria	2|Bacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_oxidored,Fer4,Fer4_7,FlpD,Pyr_redox_2
k141_1847_1	1379698.RBG1_1C00001G1326	2.94e-48	167.0	COG2006@1|root,COG2006@2|Bacteria,2NPTK@2323|unclassified Bacteria	2|Bacteria	C	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,Fer4
k141_943_1	1046724.KB889891_gene682	2.2e-06	54.7	COG3385@1|root,COG3385@2|Bacteria,1R9HB@1224|Proteobacteria	1224|Proteobacteria	L	Transposase IS4 family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k141_687_1	880073.Calab_3566	1.11e-70	235.0	COG5421@1|root,COG5421@2|Bacteria,2NQ27@2323|unclassified Bacteria	2|Bacteria	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2
k141_1312_1	523850.TON_1002	1.91e-55	184.0	COG1042@1|root,arCOG01338@2157|Archaea,2Y39C@28890|Euryarchaeota,242R3@183968|Thermococci	183968|Thermococci	C	ATP-grasp domain	-	-	6.2.1.13	ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5
k141_2206_1	933801.Ahos_0748	4.59e-123	385.0	COG0085@1|root,arCOG01762@2157|Archaea,2XPRW@28889|Crenarchaeota	28889|Crenarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K13798	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_4,RNA_pol_Rpb2_5,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
## 868 queries scanned
## Total time (seconds): 53.49253535270691
## Rate: 16.23 q/s