## Fri Jan  3 02:36:22 2025
## emapper-2.1.12
## /data/home/zhuyingjie/miniforge3/envs/eggnog/bin/emapper.py -i /data/home/zhuyingjie/01_Project/01_metagenome/mangrove/mmseqs_cluster/PRJNA947344/SRR24201524/SRR24201524_p_cluster_rep_seq.fasta --output PRJNA947344_SRR24201524 --data_dir /data/software/eggnog_database -m diamond --sensmode fast --output_dir /data/home/zhuyingjie/01_Project/01_metagenome/mangrove/annotation --temp_dir /data/software/eggnog_database/temp --excel --dbmem --cpu 24
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
k59_1345887_1	1173028.ANKO01000141_gene601	1.3e-37	145.0	COG0642@1|root,COG2199@1|root,COG2205@2|Bacteria,COG3706@2|Bacteria,1G13T@1117|Cyanobacteria,1H77Q@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_9,Response_reg
k59_1623565_1	926569.ANT_15490	3.12e-84	268.0	COG1217@1|root,COG1217@2|Bacteria,2G5NQ@200795|Chloroflexi	200795|Chloroflexi	T	elongation factor Tu domain 2 protein	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
k59_1068119_1	497964.CfE428DRAFT_2023	4.58e-27	110.0	COG0620@1|root,COG0620@2|Bacteria,46SF3@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation	metE	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_1,Meth_synt_2
k59_11988_1	1379270.AUXF01000001_gene2734	1.39e-76	254.0	COG0841@1|root,COG0841@2|Bacteria,1ZUDY@142182|Gemmatimonadetes	142182|Gemmatimonadetes	V	Protein export membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_567520_1	1157638.KB892163_gene2546	5.25e-39	149.0	COG0593@1|root,COG0593@2|Bacteria,2GJKI@201174|Actinobacteria	201174|Actinobacteria	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006172,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009133,GO:0009135,GO:0009136,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009179,GO:0009180,GO:0009185,GO:0009188,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016311,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046031,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090304,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990837	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C
k59_67350_1	867845.KI911784_gene3542	3.75e-28	115.0	COG1167@1|root,COG1167@2|Bacteria,2GAK4@200795|Chloroflexi,376KX@32061|Chloroflexia	32061|Chloroflexia	EK	aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
k59_1236179_1	558169.AGAV01000018_gene3490	1.89e-81	256.0	COG1228@1|root,COG1228@2|Bacteria,1W6UE@1239|Firmicutes,4HAQJ@91061|Bacilli	91061|Bacilli	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_178417_1	652103.Rpdx1_4939	2.87e-28	119.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2TSA7@28211|Alphaproteobacteria,3JTRC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_1236193_1	861299.J421_6088	2.71e-33	131.0	COG1680@1|root,COG1680@2|Bacteria	2|Bacteria	V	peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_901926_1	1177181.T9A_02388	5.29e-111	333.0	COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,1RMD2@1236|Gammaproteobacteria,1XHHA@135619|Oceanospirillales	135619|Oceanospirillales	E	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate	alkJ2	-	1.1.99.1	ko:K00108	ko00260,ko01100,map00260,map01100	M00555	R01025	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
k59_122697_1	545264.KB898744_gene2009	1.93e-44	164.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WXV4@135613|Chromatiales	135613|Chromatiales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1401697_1	1163407.UU7_02177	3.22e-36	127.0	COG1695@1|root,COG1695@2|Bacteria,1NJSY@1224|Proteobacteria,1SG6R@1236|Gammaproteobacteria,1X6UG@135614|Xanthomonadales	135614|Xanthomonadales	K	PadR family transcriptional regulator	-	-	-	ko:K10947	-	-	-	-	ko00000,ko03000	-	-	-	PadR
k59_790450_1	339670.Bamb_4562	3.93e-10	58.5	COG1977@1|root,COG1977@2|Bacteria,1N4M4@1224|Proteobacteria,2VUTF@28216|Betaproteobacteria,1K8VV@119060|Burkholderiaceae	28216|Betaproteobacteria	H	ThiS family	-	-	-	-	-	-	-	-	-	-	-	-	ThiS
k59_512122_1	1089550.ATTH01000001_gene1843	1.49e-71	236.0	COG0531@1|root,COG0569@1|root,COG1762@1|root,COG0531@2|Bacteria,COG0569@2|Bacteria,COG1762@2|Bacteria,4NDU2@976|Bacteroidetes,1FJTH@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	EGPT	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease,AA_permease_2,PTS_EIIA_2,TrkA_C
k59_567554_1	1121035.AUCH01000005_gene75	1.24e-81	262.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2VH4I@28216|Betaproteobacteria,2KV7T@206389|Rhodocyclales	206389|Rhodocyclales	L	DNA helicase	uvrD	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_1457702_2	379066.GAU_3049	3.43e-12	66.2	COG1595@1|root,COG1595@2|Bacteria,1ZTNW@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_1679609_1	935567.JAES01000001_gene2290	2.4e-08	59.3	COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,1S5WE@1236|Gammaproteobacteria,1X3ZI@135614|Xanthomonadales	135614|Xanthomonadales	V	beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_1512897_1	59689.fgenesh1_pm.C_scaffold_5001725	6.99e-30	123.0	COG3320@1|root,KOG1221@2759|Eukaryota,37IRY@33090|Viridiplantae,3G9S1@35493|Streptophyta,3HY82@3699|Brassicales	35493|Streptophyta	I	Catalyzes the reduction of fatty acyl-CoA to fatty alcohols	-	-	1.2.1.84	ko:K13356	ko00073,ko04146,ko04212,map00073,map04146,map04212	-	R09470	RC00004	ko00000,ko00001,ko01000	-	-	-	NAD_binding_4,Sterile
k59_1623654_1	1118054.CAGW01000014_gene285	5.24e-39	145.0	COG2843@1|root,COG2843@2|Bacteria,1V0MA@1239|Firmicutes,4HFA1@91061|Bacilli,26UAG@186822|Paenibacillaceae	91061|Bacilli	M	Bacterial capsule synthesis protein PGA_cap	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
k59_1345996_1	439235.Dalk_2069	2e-25	107.0	COG2233@1|root,COG2233@2|Bacteria,1MUN9@1224|Proteobacteria,42M4U@68525|delta/epsilon subdivisions,2WJAG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	PFAM Xanthine uracil vitamin C permease	-	-	-	ko:K03458,ko:K16345	-	-	-	-	ko00000,ko02000	2.A.40,2.A.40.4.2	-	-	Xan_ur_permease
k59_790497_1	926569.ANT_17670	1.66e-15	75.5	COG0606@1|root,COG0606@2|Bacteria,2G65P@200795|Chloroflexi	200795|Chloroflexi	O	PFAM magnesium chelatase ChlI subunit	-	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
k59_790497_2	649638.Trad_1760	8.38e-16	78.2	29XYR@1|root,30JRD@2|Bacteria,1WNBY@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Lysyl oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Lysyl_oxidase
k59_956894_1	1391646.AVSU01000021_gene3252	5.17e-05	48.9	COG1847@1|root,COG1847@2|Bacteria,1V3IN@1239|Firmicutes,249EA@186801|Clostridia,25R8V@186804|Peptostreptococcaceae	186801|Clostridia	S	R3H domain protein	jag	-	-	ko:K06346	-	-	-	-	ko00000	-	-	-	Jag_N,KH_4,R3H
k59_1068216_1	1122599.AUGR01000010_gene1051	4.02e-68	219.0	COG0277@1|root,COG0277@2|Bacteria,1MVYV@1224|Proteobacteria,1RN4G@1236|Gammaproteobacteria,1XHN3@135619|Oceanospirillales	135619|Oceanospirillales	C	FAD binding domain	glcE	-	-	ko:K11472	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_901982_1	94122.Shewana3_0140	2.03e-06	53.5	COG2866@1|root,COG2866@2|Bacteria,1QHMD@1224|Proteobacteria,1RYUG@1236|Gammaproteobacteria,2Q9QW@267890|Shewanellaceae	1236|Gammaproteobacteria	M	PFAM peptidase M14, carboxypeptidase A	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
k59_901982_2	877455.Metbo_1378	1.86e-57	189.0	COG3425@1|root,arCOG01767@2157|Archaea,2XTWE@28890|Euryarchaeota,23NSI@183925|Methanobacteria	183925|Methanobacteria	I	Belongs to the UPF0219 family	-	-	2.3.3.10	ko:K01641	ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130	M00088,M00095	R01978	RC00004,RC00503	ko00000,ko00001,ko00002,ko01000	-	-	-	ACP_syn_III_C,HMG_CoA_synt_N
k59_1568656_1	587753.EY04_25110	4.67e-45	166.0	COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,1RN6R@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	-	-	2.7.1.202,2.7.3.9	ko:K02768,ko:K08483,ko:K11183,ko:K11189	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1,8.A.7	-	-	EIIA-man,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C,PTS-HPr,PTS_EIIA_1
k59_901988_1	1122185.N792_12105	5.64e-34	122.0	2E3HM@1|root,32YG7@2|Bacteria,1NM0U@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_901988_2	1122609.AUGT01000009_gene3299	2.18e-17	76.3	2C82G@1|root,32RK9@2|Bacteria,2IRVD@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF4242)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4242
k59_735083_1	196162.Noca_3133	1.6e-34	130.0	COG3336@1|root,COG3336@2|Bacteria,2GKIR@201174|Actinobacteria,4DQ1Q@85009|Propionibacteriales	201174|Actinobacteria	S	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG)	-	-	-	ko:K02351,ko:K07245	-	-	-	-	ko00000,ko02000	9.B.62.1	-	-	Caa3_CtaG
k59_735083_2	1265313.HRUBRA_00583	0.000345	42.7	COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,1RN9D@1236|Gammaproteobacteria,1J4UE@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	COG1845 Heme copper-type cytochrome quinol oxidase, subunit 3	coxC	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
k59_1012995_1	926569.ANT_08350	3.74e-75	251.0	COG0243@1|root,COG1034@1|root,COG0243@2|Bacteria,COG1034@2|Bacteria	2|Bacteria	C	ATP synthesis coupled electron transport	nuoG	GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009405,GO:0010941,GO:0016020,GO:0016491,GO:0016651,GO:0030312,GO:0033668,GO:0035821,GO:0042981,GO:0043067,GO:0043069,GO:0044003,GO:0044068,GO:0044403,GO:0044419,GO:0044464,GO:0044531,GO:0044532,GO:0048037,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051536,GO:0051540,GO:0051701,GO:0051704,GO:0051817,GO:0052040,GO:0052041,GO:0052150,GO:0052248,GO:0052433,GO:0052490,GO:0055114,GO:0060548,GO:0065007,GO:0071944	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_12109_1	1345695.CLSA_c42710	7.61e-15	76.3	COG0681@1|root,COG0681@2|Bacteria,1V7H9@1239|Firmicutes,24HHW@186801|Clostridia,36EXX@31979|Clostridiaceae	186801|Clostridia	U	Belongs to the peptidase S26 family	lepB2	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
k59_1735211_2	335543.Sfum_0023	2.47e-23	97.8	COG1082@1|root,COG1082@2|Bacteria,1N8KJ@1224|Proteobacteria,42SR1@68525|delta/epsilon subdivisions,2WP5P@28221|Deltaproteobacteria,2MQKJ@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
k59_12112_1	861299.J421_3996	7.79e-22	99.0	COG2954@1|root,COG5607@1|root,COG2954@2|Bacteria,COG5607@2|Bacteria,1ZTYF@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	CYTH	-	-	-	-	-	-	-	-	-	-	-	-	CHAD
k59_902008_1	926556.Echvi_2721	8.52e-91	290.0	2CDRA@1|root,2Z7QN@2|Bacteria,4NHVB@976|Bacteroidetes,47T8Z@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1401789_1	1120966.AUBU01000012_gene67	4.59e-10	61.6	COG4447@1|root,COG4447@2|Bacteria,4NESU@976|Bacteroidetes,47JPK@768503|Cytophagia	976|Bacteroidetes	S	Sortilin, neurotensin receptor 3,	-	-	-	-	-	-	-	-	-	-	-	-	BNR_6,Sortilin-Vps10
k59_67457_1	313628.LNTAR_05979	6.79e-08	58.9	COG0651@1|root,COG0651@2|Bacteria	2|Bacteria	CP	ATP synthesis coupled electron transport	mrpD	GO:0003674,GO:0005215,GO:0005451,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015081,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015385,GO:0015491,GO:0015672,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0035725,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0098655,GO:0098660,GO:0098662,GO:0099516,GO:1902600	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	iSB619.SA_RS04615	Proton_antipo_M
k59_790547_1	1267534.KB906754_gene3742	2.1e-25	112.0	COG0577@1|root,COG0577@2|Bacteria,3Y34I@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_345198_1	555079.Toce_0288	2.12e-09	64.3	COG2348@1|root,COG2348@2|Bacteria,1TRZU@1239|Firmicutes,24AU8@186801|Clostridia,42F0P@68295|Thermoanaerobacterales	186801|Clostridia	V	FemAB family	femX	-	2.3.2.10,2.3.2.16	ko:K05363,ko:K11693	ko00550,ko01100,map00550,map01100	-	R08776,R08779	RC00055,RC00096	ko00000,ko00001,ko01000,ko01011	-	-	-	FemAB
k59_401159_1	713586.KB900536_gene890	4.3e-55	182.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,1RR4F@1236|Gammaproteobacteria,1WXZW@135613|Chromatiales	135613|Chromatiales	L	PFAM integrase	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_2
k59_234540_1	742723.HMPREF9477_01088	1.99e-13	75.1	arCOG08054@1|root,2Z8AD@2|Bacteria,1TQ1J@1239|Firmicutes,2485U@186801|Clostridia,27I5F@186928|unclassified Lachnospiraceae	186801|Clostridia	S	Carbohydrate-binding domain-containing protein Cthe_2159	-	GO:0001871,GO:0003674,GO:0005488,GO:0005509,GO:0030246,GO:0030247,GO:0030248,GO:0043167,GO:0043169,GO:0046872,GO:0048028,GO:2001062	-	-	-	-	-	-	-	-	-	-	Cthe_2159
k59_956952_1	1163408.UU9_03882	1.27e-77	243.0	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,1SYDD@1236|Gammaproteobacteria,1X52V@135614|Xanthomonadales	135614|Xanthomonadales	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
k59_234542_1	1304872.JAGC01000003_gene3177	2.55e-21	97.8	COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,42NJD@68525|delta/epsilon subdivisions,2WJFK@28221|Deltaproteobacteria,2M8P4@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	Belongs to the peptidase S16 family	-	-	3.4.21.53	ko:K04076	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AAA_32,Lon_C
k59_790559_1	1380394.JADL01000002_gene1099	1.04e-122	370.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2TSSI@28211|Alphaproteobacteria,2JPSP@204441|Rhodospirillales	204441|Rhodospirillales	I	COG1022 Long-chain acyl-CoA synthetases (AMP-forming)	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
k59_290145_1	382464.ABSI01000006_gene852	1.98e-60	211.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1144@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1144@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor	preT	-	1.2.7.1	ko:K00171,ko:K03737	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034,R10866	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_20,Fer4_6,PFOR_II,POR,POR_N,Pyr_redox_2,Pyr_redox_3,TPP_enzyme_C
k59_1735241_1	671143.DAMO_1392	1.51e-99	310.0	COG0317@1|root,COG0317@2|Bacteria,2NNM0@2323|unclassified Bacteria	2|Bacteria	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5,3.1.7.2	ko:K00951,ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
k59_1068277_1	269799.Gmet_0410	1.07e-11	65.9	COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,42MJY@68525|delta/epsilon subdivisions,2WJAQ@28221|Deltaproteobacteria,43T3Z@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	AlaDh_PNT_C,FAD_binding_3,Mur_ligase_C,Mur_ligase_M,NAD_binding_8
k59_1068277_2	330214.NIDE0758	1.36e-64	207.0	COG0472@1|root,COG0472@2|Bacteria,3J0C4@40117|Nitrospirae	40117|Nitrospirae	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
k59_1124473_1	909663.KI867150_gene247	1.37e-92	286.0	COG0160@1|root,COG0160@2|Bacteria,1MWY6@1224|Proteobacteria,42MB7@68525|delta/epsilon subdivisions,2WJVU@28221|Deltaproteobacteria,2MQ96@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.19,2.6.1.22	ko:K00823,ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_1568722_1	1869.MB27_20160	2.47e-09	58.9	COG1960@1|root,COG1960@2|Bacteria,2GKK9@201174|Actinobacteria,4DB5R@85008|Micromonosporales	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, middle domain	fadE10	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,DUF1974
k59_1623746_1	686578.AFFX01000001_gene1570	9.14e-71	228.0	COG0155@1|root,COG0155@2|Bacteria,1MVVB@1224|Proteobacteria,1RMFH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate	cysI	-	1.8.1.2	ko:K00381	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R00858	RC00065	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
k59_1457815_1	1429046.RR21198_0963	4.15e-08	53.9	COG0846@1|root,COG0846@2|Bacteria,2GJI3@201174|Actinobacteria,4FWNQ@85025|Nocardiaceae	201174|Actinobacteria	K	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form	cobB	GO:0000726,GO:0003674,GO:0003824,GO:0003953,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006303,GO:0006464,GO:0006471,GO:0006476,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016787,GO:0016798,GO:0016799,GO:0019213,GO:0019538,GO:0030312,GO:0033554,GO:0033558,GO:0034641,GO:0034979,GO:0035601,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0070213,GO:0071214,GO:0071478,GO:0071479,GO:0071704,GO:0071944,GO:0090304,GO:0098732,GO:0104004,GO:0140096,GO:1901360,GO:1901564	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
k59_1068299_1	861299.J421_2881	3.89e-89	280.0	COG2812@1|root,COG2812@2|Bacteria,1ZTFV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
k59_512276_1	991905.SL003B_0824	3.49e-92	280.0	COG4665@1|root,COG4665@2|Bacteria,1R4T4@1224|Proteobacteria,2U2FK@28211|Alphaproteobacteria,4BREP@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	Q	TRAP-type mannitol chloroaromatic compound transport system, small permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
k59_1346110_1	1054213.HMPREF9946_03527	2.15e-37	143.0	COG3225@1|root,COG3225@2|Bacteria,1MY63@1224|Proteobacteria,2U1SX@28211|Alphaproteobacteria,2JRJ2@204441|Rhodospirillales	204441|Rhodospirillales	N	ABC-type uncharacterized transport system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux
k59_1623765_1	257310.BB0896	3.17e-58	190.0	COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,2VI82@28216|Betaproteobacteria,3T1FE@506|Alcaligenaceae	28216|Betaproteobacteria	S	Zn-dependent hydrolases, including glyoxylases	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_1735281_1	365528.KB891257_gene4784	5.6e-60	202.0	COG0028@1|root,COG0028@2|Bacteria,2GN3X@201174|Actinobacteria	201174|Actinobacteria	EH	Belongs to the TPP enzyme family	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_401217_1	1131814.JAFO01000001_gene3472	3.5e-12	71.2	COG3618@1|root,COG3618@2|Bacteria,1N2QM@1224|Proteobacteria,2TTZK@28211|Alphaproteobacteria,3F1N4@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
k59_845542_1	497964.CfE428DRAFT_0790	8.13e-09	56.2	COG3875@1|root,COG3875@2|Bacteria	2|Bacteria	S	lactate racemase activity	-	-	5.1.2.1	ko:K22373	ko00620,map00620	-	R01450	RC00519	ko00000,ko00001,ko01000	-	-	-	DUF2088
k59_845542_2	43989.cce_1985	4.28e-53	173.0	COG3265@1|root,COG3265@2|Bacteria,1G60D@1117|Cyanobacteria,3KI3B@43988|Cyanothece	1117|Cyanobacteria	F	TIGRFAM carbohydrate kinase, thermoresistant glucokinase family	gntK	-	2.7.1.12	ko:K00851	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	-	R01737	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	SKI
k59_679570_1	1267534.KB906754_gene3160	2.49e-39	134.0	2EE2W@1|root,337XH@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_679570_2	266835.14026239	2.44e-17	79.0	COG0662@1|root,COG0662@2|Bacteria,1N56T@1224|Proteobacteria,2UCUS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_1625868_1	479434.Sthe_3191	3.91e-51	169.0	COG1622@1|root,COG1622@2|Bacteria,2GA3I@200795|Chloroflexi,27Z0J@189775|Thermomicrobia	189775|Thermomicrobia	C	Cytochrome C oxidase subunit II, periplasmic domain	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2
k59_1625868_2	1223521.BBJX01000002_gene2860	3.86e-05	45.8	COG0843@1|root,COG0843@2|Bacteria,1R57U@1224|Proteobacteria,2VJ1N@28216|Betaproteobacteria,4AHFT@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM Cytochrome c oxidase, subunit I	cbaA	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_1681961_1	935557.ATYB01000014_gene3092	9.01e-24	107.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4BAVP@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,TPR_16
k59_1737511_1	935840.JAEQ01000020_gene2336	8.18e-66	219.0	COG0526@1|root,COG0526@2|Bacteria,1RC8N@1224|Proteobacteria,2U7IW@28211|Alphaproteobacteria,43NJ4@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
k59_1070446_2	926569.ANT_25700	2.54e-13	68.6	COG0265@1|root,COG0642@1|root,COG2203@1|root,COG0265@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,2G7SE@200795|Chloroflexi	200795|Chloroflexi	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA
k59_196421_1	1380354.JIAN01000008_gene3313	1e-73	228.0	COG1028@1|root,COG1028@2|Bacteria,2GJU1@201174|Actinobacteria	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	1.1.1.127	ko:K00065	ko00040,map00040	-	R01542	RC00089	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
k59_196421_2	1128421.JAGA01000002_gene1494	2.52e-22	96.3	COG1904@1|root,COG1904@2|Bacteria	2|Bacteria	G	glucuronate isomerase activity	uxaC	-	5.3.1.12	ko:K01812	ko00040,ko01100,map00040,map01100	M00061,M00631	R01482,R01983	RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	UxaC
k59_1586949_1	1416760.AYMS01000036_gene2131	1.63e-14	78.6	COG1629@1|root,COG1629@2|Bacteria,4PKAS@976|Bacteroidetes,1IJ5T@117743|Flavobacteriia,47HB9@76831|Myroides	976|Bacteroidetes	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
k59_698189_1	575540.Isop_3282	5.34e-66	225.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,2IX33@203682|Planctomycetes	203682|Planctomycetes	M	Tricorn protease C1 domain	-	-	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
k59_1255025_1	1403819.BATR01000189_gene6455	1.76e-16	86.7	COG0768@1|root,COG0768@2|Bacteria,46TSQ@74201|Verrucomicrobia,2ITKB@203494|Verrucomicrobiae	2|Bacteria	M	Penicillin-binding Protein dimerisation domain	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
k59_1032835_1	313596.RB2501_04435	1.45e-22	97.1	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,4NFBK@976|Bacteroidetes,1HY8A@117743|Flavobacteriia	976|Bacteroidetes	EU	peptidase S9	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9,Peptidase_S9_N
k59_1142977_1	1141663.OOC_14679	0.000184	49.3	COG3263@1|root,COG3263@2|Bacteria,1MVKV@1224|Proteobacteria,1RMCA@1236|Gammaproteobacteria,3Z72A@586|Providencia	1236|Gammaproteobacteria	P	Psort location CytoplasmicMembrane, score 10.00	cvrA	-	-	ko:K11105	-	-	-	-	ko00000,ko02000	2.A.36.6	-	-	CorC_HlyC,Na_H_Exchanger,TrkA_C
k59_1419854_1	2074.JNYD01000011_gene123	1.83e-80	253.0	COG0174@1|root,COG0174@2|Bacteria,2GMN1@201174|Actinobacteria,4DZSM@85010|Pseudonocardiales	201174|Actinobacteria	E	TIGRFAM glutamine synthetase, type I	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
k59_1586972_1	861299.J421_0305	1.3e-43	153.0	COG1413@1|root,COG1413@2|Bacteria,1ZTU2@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	HEAT repeats	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
k59_1197719_1	1123366.TH3_21820	5.36e-40	141.0	COG3293@1|root,COG3293@2|Bacteria,1PVIT@1224|Proteobacteria,2TURP@28211|Alphaproteobacteria,2JW1A@204441|Rhodospirillales	204441|Rhodospirillales	L	Putative transposase of IS4/5 family (DUF4096)	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4096
k59_1197719_2	269796.Rru_A1516	4.12e-67	207.0	COG3293@1|root,COG3293@2|Bacteria,1RFRK@1224|Proteobacteria,2U8TH@28211|Alphaproteobacteria,2JTJP@204441|Rhodospirillales	204441|Rhodospirillales	L	Putative transposase of IS4/5 family (DUF4096)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4096
k59_1142992_1	671143.DAMO_1077	1.12e-92	283.0	COG0112@1|root,COG0112@2|Bacteria,2NP28@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	GO:0001505,GO:0003674,GO:0003824,GO:0004372,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006546,GO:0006563,GO:0006565,GO:0006730,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009069,GO:0009070,GO:0009071,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016741,GO:0016742,GO:0017144,GO:0019264,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0042133,GO:0042135,GO:0042136,GO:0042737,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0065007,GO:0065008,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	iG2583_1286.G2583_3081,iIT341.HP0183	SHMT
k59_698213_2	1151292.QEW_0068	1.14e-23	96.7	COG0250@1|root,COG0250@2|Bacteria,1TR3P@1239|Firmicutes,248XB@186801|Clostridia,25RDG@186804|Peptostreptococcaceae	186801|Clostridia	K	Participates in transcription elongation, termination and antitermination	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
k59_1032851_1	1121904.ARBP01000006_gene3811	8.47e-23	96.3	COG0192@1|root,COG0192@2|Bacteria,4NG7Y@976|Bacteroidetes,47JW7@768503|Cytophagia	976|Bacteroidetes	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
k59_1032851_2	553385.JEMF01000018_gene860	6.29e-28	108.0	COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,1RMEX@1236|Gammaproteobacteria,1XH75@135619|Oceanospirillales	135619|Oceanospirillales	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_476858_2	33876.JNXY01000006_gene1129	4.35e-08	56.6	COG0836@1|root,COG0836@2|Bacteria,2GIRM@201174|Actinobacteria,4D91K@85008|Micromonosporales	201174|Actinobacteria	M	Mannose-1-phosphate guanylyltransferase	manC	-	2.7.7.13	ko:K00971	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
k59_1255047_1	641491.DND132_0247	2.12e-29	125.0	COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,42MBB@68525|delta/epsilon subdivisions,2WIU1@28221|Deltaproteobacteria,2M8NF@213115|Desulfovibrionales	28221|Deltaproteobacteria	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
k59_1586980_1	861299.J421_2768	8.16e-119	376.0	COG0086@1|root,COG0086@2|Bacteria,1ZSZQ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_698221_1	861299.J421_1490	6.21e-62	207.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1ZSVF@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR,POR_N
k59_698221_2	861299.J421_1491	2.79e-25	103.0	COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1ZSZ7@142182|Gemmatimonadetes	142182|Gemmatimonadetes	CE	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_20,Fer4_7,Pyr_redox_2,Pyr_redox_3
k59_585451_1	313603.FB2170_12956	6.58e-33	131.0	COG1228@1|root,COG1228@2|Bacteria,4NEV0@976|Bacteroidetes,1HZW4@117743|Flavobacteriia,2PHHE@252356|Maribacter	976|Bacteroidetes	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_1752559_1	1229780.BN381_70031	5.6e-25	103.0	COG0659@1|root,COG0659@2|Bacteria,2GJCB@201174|Actinobacteria,3UXE3@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	U	STAS domain	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
k59_1143008_1	926550.CLDAP_05500	5.43e-44	162.0	COG1193@1|root,COG1193@2|Bacteria,2G5R8@200795|Chloroflexi	200795|Chloroflexi	L	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_III,MutS_V,Smr
k59_862768_1	234267.Acid_3131	2.93e-73	239.0	COG5276@1|root,COG5276@2|Bacteria,3Y393@57723|Acidobacteria	57723|Acidobacteria	S	repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_140670_1	563031.HMPREF0666_00576	9.91e-22	92.0	COG1212@1|root,COG1212@2|Bacteria,4NG4B@976|Bacteroidetes,2FMHD@200643|Bacteroidia	976|Bacteroidetes	M	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria	kdsB	-	2.7.7.38	ko:K00979	ko00540,ko01100,map00540,map01100	M00063	R03351,R11396	RC00152,RC00910	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_3
k59_140670_2	909663.KI867150_gene797	1.57e-20	91.7	COG2870@1|root,COG2870@2|Bacteria,1MV3Z@1224|Proteobacteria,42MBC@68525|delta/epsilon subdivisions,2WIKU@28221|Deltaproteobacteria,2MQGF@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	hldE	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016757,GO:0016772,GO:0019200,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0046835,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.7.1.167,2.7.7.70	ko:K03272	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	iAF987.Gmet_0922	CTP_transf_like,PfkB
k59_30125_1	187272.Mlg_0551	3.24e-77	246.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,1RMWE@1236|Gammaproteobacteria,1WWU2@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
k59_252093_1	883.DvMF_1631	1.19e-68	216.0	COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,42RZQ@68525|delta/epsilon subdivisions,2WNKI@28221|Deltaproteobacteria,2MG4G@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	response regulator, receiver	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_1143040_1	713586.KB900536_gene2394	2.19e-84	258.0	COG1816@1|root,COG1816@2|Bacteria,1MWBV@1224|Proteobacteria,1RNVI@1236|Gammaproteobacteria,1WZJ8@135613|Chromatiales	135613|Chromatiales	F	Adenosine/AMP deaminase	-	-	3.5.4.2,3.5.4.4	ko:K01488,ko:K21053	ko00230,ko01100,ko05340,map00230,map01100,map05340	-	R01244,R01560,R02556	RC00477	ko00000,ko00001,ko01000	-	-	-	A_deaminase
k59_1699210_1	331869.BAL199_30037	7.12e-60	195.0	COG1173@1|root,COG1173@2|Bacteria,1MUG0@1224|Proteobacteria,2TT4V@28211|Alphaproteobacteria,4BPQN@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	EP	COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
k59_476894_1	1242864.D187_007126	6.29e-45	152.0	COG0526@1|root,COG0526@2|Bacteria,1N726@1224|Proteobacteria,42U61@68525|delta/epsilon subdivisions,2WQRF@28221|Deltaproteobacteria,2YVYE@29|Myxococcales	28221|Deltaproteobacteria	CO	Redoxin	dsbE	-	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	AhpC-TSA
k59_698259_1	999541.bgla_1g33810	1.21e-24	107.0	COG0744@1|root,COG0768@1|root,COG0744@2|Bacteria,COG0768@2|Bacteria,1NRPB@1224|Proteobacteria,2VJ7F@28216|Betaproteobacteria,1JZUT@119060|Burkholderiaceae	28216|Betaproteobacteria	M	PFAM glycosyl transferase, family 51	-	-	-	-	-	-	-	-	-	-	-	-	Transgly,Transpeptidase
k59_1032895_1	926569.ANT_03530	1.39e-73	247.0	COG0188@1|root,COG0188@2|Bacteria,2G5Q2@200795|Chloroflexi	200795|Chloroflexi	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_1309907_1	264732.Moth_2150	0.000105	52.0	COG2203@1|root,COG3437@1|root,COG4936@1|root,COG2203@2|Bacteria,COG3437@2|Bacteria,COG4936@2|Bacteria,1V7YT@1239|Firmicutes,25ET2@186801|Clostridia,42JGC@68295|Thermoanaerobacterales	186801|Clostridia	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HD,PAS_9,PocR,SBP_bac_3
k59_30155_2	649638.Trad_1077	9.98e-34	121.0	COG0316@1|root,COG0316@2|Bacteria,1WKA9@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Belongs to the HesB IscA family	hesB	-	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
k59_1752592_1	1198114.AciX9_2007	1.59e-91	280.0	COG2826@1|root,COG2826@2|Bacteria,3Y896@57723|Acidobacteria,2JN59@204432|Acidobacteriia	204432|Acidobacteriia	L	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_38,rve
k59_640721_1	493475.GARC_0774	2.38e-77	246.0	COG0475@1|root,COG0475@2|Bacteria,1QTPK@1224|Proteobacteria,1RXTT@1236|Gammaproteobacteria,46C83@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
k59_1309916_1	518766.Rmar_1827	1.43e-81	250.0	COG0581@1|root,COG0581@2|Bacteria,4NGBA@976|Bacteroidetes,1FIYE@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	P	Binding-protein-dependent transport system inner membrane component	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
k59_640723_1	5691.EAN77147	8.42e-72	231.0	COG0626@1|root,KOG0053@2759|Eukaryota,3XT9E@5653|Kinetoplastida	5653|Kinetoplastida	E	cystathione gamma lyase	-	-	-	-	-	-	-	-	-	-	-	-	Cys_Met_Meta_PP
k59_921969_1	1238182.C882_4358	8.3e-84	264.0	COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,2TQSW@28211|Alphaproteobacteria,2JPMD@204441|Rhodospirillales	204441|Rhodospirillales	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
k59_585514_1	531844.FIC_01349	4.04e-25	102.0	COG0545@1|root,COG0652@1|root,COG0545@2|Bacteria,COG0652@2|Bacteria,4NDW4@976|Bacteroidetes,1HYBT@117743|Flavobacteriia,405WH@61432|unclassified Flavobacteriaceae	976|Bacteroidetes	O	FKBP-type peptidyl-prolyl cis-trans isomerase	ppiC	-	5.2.1.8	ko:K01802,ko:K03767,ko:K03772	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	FKBP_C,Pro_isomerase
k59_698285_1	944481.JAFP01000001_gene616	1.63e-94	296.0	COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,42NFP@68525|delta/epsilon subdivisions,2WK64@28221|Deltaproteobacteria,2M6Q5@213113|Desulfurellales	28221|Deltaproteobacteria	EQ	Hydantoinase/oxoprolinase N-terminal region	hyuA	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
k59_640740_1	1341151.ASZU01000004_gene85	1.88e-39	135.0	COG1051@1|root,COG1051@2|Bacteria,1V6D5@1239|Firmicutes,4HJTU@91061|Bacilli,27CV0@186824|Thermoactinomycetaceae	91061|Bacilli	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
k59_1641070_1	222534.KB893722_gene522	7.01e-16	82.4	COG3653@1|root,COG3653@2|Bacteria,2GKMK@201174|Actinobacteria	201174|Actinobacteria	Q	N-acyl-D-aspartate D-glutamate deacylase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_140735_1	1123261.AXDW01000002_gene1525	1.13e-11	63.2	COG2096@1|root,COG2096@2|Bacteria,1RDUF@1224|Proteobacteria,1S40D@1236|Gammaproteobacteria,1X50D@135614|Xanthomonadales	135614|Xanthomonadales	S	adenosyltransferase	-	-	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans
k59_476947_2	247490.KSU1_C0559	2.76e-36	123.0	COG1598@1|root,COG1598@2|Bacteria	2|Bacteria	N	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_476947_3	221288.JH992901_gene5628	8.51e-20	80.9	COG1598@1|root,COG1598@2|Bacteria,1G978@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1032956_1	448385.sce6409	8.81e-100	310.0	COG1506@1|root,COG1506@2|Bacteria,1MUJ3@1224|Proteobacteria,42Q8W@68525|delta/epsilon subdivisions,2WJVN@28221|Deltaproteobacteria,2YWG3@29|Myxococcales	28221|Deltaproteobacteria	E	X-Pro dipeptidyl-peptidase (S15 family)	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9,Peptidase_S9_N
k59_1255157_2	926550.CLDAP_21750	5.34e-43	150.0	COG2876@1|root,COG2876@2|Bacteria,2G643@200795|Chloroflexi	200795|Chloroflexi	E	PFAM DAHP synthetase I KDSA	-	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
k59_752757_1	323261.Noc_0937	1.07e-51	178.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RPAB@1236|Gammaproteobacteria,1WWXD@135613|Chromatiales	135613|Chromatiales	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_17,Fer4_7,Fer4_8
k59_140752_1	644968.DFW101_2155	7.23e-07	56.6	COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,43CS7@68525|delta/epsilon subdivisions,2X7ZW@28221|Deltaproteobacteria,2MHC1@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	histidine kinase HAMP region domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_7,PAS_9,Response_reg,SBP_bac_3,sCache_3_2
k59_1752636_2	366394.Smed_0791	5.9e-28	107.0	COG0299@1|root,COG0299@2|Bacteria,1MWN1@1224|Proteobacteria,2TRY6@28211|Alphaproteobacteria,4B8H9@82115|Rhizobiaceae	28211|Alphaproteobacteria	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	GO:0003674,GO:0003824,GO:0004644,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016740,GO:0016741,GO:0016742,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N,YjbR
k59_924061_1	1254432.SCE1572_15135	1.48e-28	118.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42QS7@68525|delta/epsilon subdivisions,2X74U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	IQ	AMP-binding enzyme	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding
k59_311084_1	1403313.AXBR01000009_gene861	2.06e-29	117.0	COG2186@1|root,COG2186@2|Bacteria,1V2TU@1239|Firmicutes,4HDHI@91061|Bacilli,1ZD1T@1386|Bacillus	91061|Bacilli	K	COG2186 Transcriptional regulators	yvfI	-	-	ko:K05799	-	-	-	-	ko00000,ko03000	-	-	-	FCD,GntR
k59_864961_1	1189612.A33Q_0045	2.85e-12	71.6	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,4NFW7@976|Bacteroidetes	976|Bacteroidetes	K	COGs COG5616 integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,TPR_8
k59_1199792_2	551789.ATVJ01000001_gene1039	7.77e-42	142.0	2C42J@1|root,3359Y@2|Bacteria,1NJYP@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1089109_2	1041139.KB902613_gene287	1.43e-06	53.1	COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,2TRWZ@28211|Alphaproteobacteria,4B8PG@82115|Rhizobiaceae	28211|Alphaproteobacteria	V	Beta-lactamase	MA20_00470	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_1754526_1	113395.AXAI01000002_gene5219	2.8e-45	166.0	COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TTJ0@28211|Alphaproteobacteria,3JS5D@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,PAS_7,dCache_1
k59_1035105_1	1532558.JL39_00250	2.68e-70	225.0	COG1638@1|root,COG1638@2|Bacteria,1MVHI@1224|Proteobacteria,2TQVT@28211|Alphaproteobacteria,4BC76@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	MA20_18675	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_978734_1	235985.BBPN01000050_gene8368	1.38e-22	94.4	COG3217@1|root,COG3217@2|Bacteria	2|Bacteria	S	molybdenum ion binding	-	-	-	ko:K07140	-	-	-	-	ko00000	-	-	-	MOSC,MOSC_N
k59_1367034_1	1158762.KB898048_gene717	4.99e-94	280.0	COG0740@1|root,COG0740@2|Bacteria,1MV46@1224|Proteobacteria,1RNR6@1236|Gammaproteobacteria,1WW24@135613|Chromatiales	135613|Chromatiales	OU	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
k59_586046_1	234267.Acid_6847	2.36e-09	59.7	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
k59_1531388_1	1121428.DESHY_110006___1	3.97e-62	207.0	COG1866@1|root,COG1866@2|Bacteria,1TPQV@1239|Firmicutes,248JE@186801|Clostridia,26321@186807|Peptococcaceae	186801|Clostridia	F	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA	pckA	-	4.1.1.49	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00170	R00341	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_ATP
k59_809205_1	56780.SYN_02684	6.82e-62	212.0	COG5360@1|root,COG5360@2|Bacteria,1MZ5X@1224|Proteobacteria,42PG1@68525|delta/epsilon subdivisions,2WP6V@28221|Deltaproteobacteria,2MRGQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Heparinase II/III N-terminus	-	-	-	-	-	-	-	-	-	-	-	-	Hepar_II_III,Hepar_II_III_N
k59_586057_1	243365.CV_1535	3.27e-36	135.0	COG0697@1|root,COG0697@2|Bacteria,1MZXM@1224|Proteobacteria,2VK90@28216|Betaproteobacteria,2KQSE@206351|Neisseriales	206351|Neisseriales	EG	Psort location CytoplasmicMembrane, score 10.00	-	-	-	ko:K15270	-	-	-	-	ko00000,ko02000	2.A.7.3.7	-	-	EamA
k59_252610_1	469381.Dpep_2234	2.62e-59	199.0	COG0215@1|root,COG0215@2|Bacteria,3TAAB@508458|Synergistetes	508458|Synergistetes	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
k59_1255626_1	1382359.JIAL01000001_gene198	5.21e-18	77.4	2E34G@1|root,32Y4J@2|Bacteria,3Y5JB@57723|Acidobacteria,2JJW7@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_141213_1	56780.SYN_01756	2.65e-11	68.9	COG4726@1|root,COG4726@2|Bacteria,1NK1B@1224|Proteobacteria	1224|Proteobacteria	NU	Pilus assembly protein PilX	-	-	-	ko:K02673	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilX_N
k59_586070_1	796940.HMPREF9628_01680	7.9e-10	58.5	COG1725@1|root,COG1725@2|Bacteria,1VFD0@1239|Firmicutes,24MTU@186801|Clostridia,25TTN@186804|Peptostreptococcaceae	186801|Clostridia	K	Transcriptional regulator	ytrA	-	-	ko:K07979	-	-	-	-	ko00000,ko03000	-	-	-	GntR
k59_586070_2	97139.C824_05880	3.99e-12	69.7	COG1131@1|root,COG1131@2|Bacteria,1TPZR@1239|Firmicutes,247NW@186801|Clostridia,36E9X@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1476778_1	1121918.ARWE01000001_gene3039	1.93e-22	95.1	COG0668@1|root,COG0668@2|Bacteria,1PMY3@1224|Proteobacteria,42M4K@68525|delta/epsilon subdivisions,2WWCN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
k59_1476778_2	398767.Glov_2623	2.94e-16	80.1	COG1227@1|root,COG4109@1|root,COG1227@2|Bacteria,COG4109@2|Bacteria,1P9JN@1224|Proteobacteria,42N0W@68525|delta/epsilon subdivisions,2WK0Q@28221|Deltaproteobacteria,43UA9@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	DHHA2	ppaC	-	3.6.1.1	ko:K15986	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	CBS,DHH,DHHA2,DRTGG
k59_922508_2	1089552.KI911559_gene478	1.08e-19	83.6	COG2350@1|root,COG2350@2|Bacteria,1MZ9Z@1224|Proteobacteria,2UF4X@28211|Alphaproteobacteria,2JTUA@204441|Rhodospirillales	204441|Rhodospirillales	S	Protein conserved in bacteria	-	-	-	ko:K09780	-	-	-	-	ko00000	-	-	-	YCII
k59_86183_1	1122238.AULR01000005_gene2238	2.81e-09	62.8	COG3525@1|root,COG3525@2|Bacteria	2|Bacteria	G	beta-N-acetylhexosaminidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_20,Glyco_hydro_20b
k59_1087512_1	945713.IALB_1660	5.87e-18	81.3	COG2391@1|root,COG2391@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
k59_1087512_2	880073.Calab_2451	1.21e-19	85.5	COG2391@1|root,COG2391@2|Bacteria,2NRQM@2323|unclassified Bacteria	2|Bacteria	S	Sulphur transport	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Rhodanese,Sulf_transp
k59_1143635_1	323848.Nmul_A1015	6.88e-40	145.0	COG0649@1|root,COG0852@1|root,COG0649@2|Bacteria,COG0852@2|Bacteria,1MVIN@1224|Proteobacteria,2VHEC@28216|Betaproteobacteria,3743I@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Respiratory-chain NADH dehydrogenase, 49 Kd subunit	-	-	1.6.5.3	ko:K13378	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa,Complex1_49kDa
k59_1143635_2	323848.Nmul_A1016	2.8e-47	155.0	COG1905@1|root,COG1905@2|Bacteria,1MWS2@1224|Proteobacteria,2WA30@28216|Betaproteobacteria,3742N@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Thioredoxin-like [2Fe-2S] ferredoxin	-	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
k59_1310463_1	1163745.HCD_03880	5.1e-15	71.2	COG1862@1|root,COG1862@2|Bacteria,1MZT2@1224|Proteobacteria,42V1U@68525|delta/epsilon subdivisions,2YPSE@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	U	Preprotein translocase	yajC	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
k59_1310463_2	1313304.CALK_1921	0.000138	45.1	COG0343@1|root,COG0343@2|Bacteria	2|Bacteria	F	queuine tRNA-ribosyltransferase activity	tgt	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046116,GO:0046483,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
k59_86190_1	478741.JAFS01000002_gene203	1.12e-125	372.0	COG3328@1|root,COG3328@2|Bacteria	2|Bacteria	L	transposase activity	tnp	-	-	ko:K07493	-	-	-	-	ko00000	-	-	-	Transposase_mut
k59_477499_1	666685.R2APBS1_0174	2.19e-61	212.0	COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,1RSNV@1236|Gammaproteobacteria,1X46E@135614|Xanthomonadales	135614|Xanthomonadales	L	Helicase	lhr1	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
k59_809256_2	1121422.AUMW01000015_gene2614	2.06e-47	167.0	COG1134@1|root,COG1134@2|Bacteria,1TQKK@1239|Firmicutes,24A5V@186801|Clostridia,26251@186807|Peptococcaceae	186801|Clostridia	GM	PFAM ABC transporter	tagH	-	3.6.3.40	ko:K01990,ko:K09691,ko:K09693	ko02010,map02010	M00250,M00251,M00254	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.103,3.A.1.104	-	-	ABC_tran,Wzt_C
k59_922533_1	247490.KSU1_C0431	8.7e-43	155.0	COG2244@1|root,COG2244@2|Bacteria,2J1D3@203682|Planctomycetes	203682|Planctomycetes	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt_3
k59_1310493_1	479434.Sthe_0596	4.06e-50	174.0	COG0492@1|root,COG3437@1|root,COG0492@2|Bacteria,COG3437@2|Bacteria,2G5Z5@200795|Chloroflexi	200795|Chloroflexi	C	FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Response_reg
k59_363912_1	33876.JNXY01000016_gene7002	2.29e-17	87.8	COG0477@1|root,COG0477@2|Bacteria,2GK06@201174|Actinobacteria,4DBVX@85008|Micromonosporales	201174|Actinobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
k59_809278_1	1524467.IV04_04730	1.13e-20	94.7	COG1319@1|root,COG1319@2|Bacteria,1RCRH@1224|Proteobacteria,1T26M@1236|Gammaproteobacteria,405S5@613|Serratia	1236|Gammaproteobacteria	C	CO dehydrogenase flavoprotein C-terminal domain	xdhB	GO:0000166,GO:0003674,GO:0003824,GO:0004854,GO:0005488,GO:0006139,GO:0006144,GO:0006145,GO:0006150,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009114,GO:0009987,GO:0016491,GO:0016725,GO:0016726,GO:0019439,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0046100,GO:0046113,GO:0046483,GO:0046700,GO:0048037,GO:0050660,GO:0050662,GO:0055086,GO:0055114,GO:0071704,GO:0071949,GO:0072521,GO:0072523,GO:0097159,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575	1.17.1.4,1.3.99.8	ko:K13479,ko:K16878	ko00230,ko00365,ko01100,ko01120,map00230,map00365,map01100,map01120	M00546	R01768,R02103,R02987	RC00143,RC01856	ko00000,ko00001,ko00002,ko01000	-	-	iLF82_1304.LF82_2444,iNRG857_1313.NRG857_14070,iS_1188.S3069	CO_deh_flav_C,FAD_binding_5
k59_363924_1	1229780.BN381_80207	1.2e-22	95.9	COG3336@1|root,COG3336@2|Bacteria	2|Bacteria	G	cytochrome c oxidase	ctaG	-	-	ko:K02351,ko:K02862	-	-	-	-	ko00000	-	-	-	Caa3_CtaG
k59_363924_2	379066.GAU_2937	2.69e-31	120.0	COG1999@1|root,COG2847@1|root,COG1999@2|Bacteria,COG2847@2|Bacteria	2|Bacteria	P	Copper chaperone PCu(A)C	hyaE	GO:0003674,GO:0005048,GO:0005488,GO:0033218,GO:0042277	-	ko:K03619,ko:K07152,ko:K09796	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	HyaE,PCuAC,SCO1-SenC
k59_863417_1	83406.HDN1F_07230	1.69e-62	215.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365,HATPase_c,HisKA,Hpt,PAS_3,PAS_9,Response_reg
k59_477537_1	981384.AEYW01000006_gene2983	4.22e-42	150.0	COG2114@1|root,COG2114@2|Bacteria,1ND4Q@1224|Proteobacteria,2U51W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Protein of unknown function (DUF2652)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2652,Polyketide_cyc2
k59_1420556_1	83332.Rv1511	2.09e-16	77.0	COG1089@1|root,COG1089@2|Bacteria,2GNMA@201174|Actinobacteria,234QN@1762|Mycobacteriaceae	201174|Actinobacteria	M	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose	gmd	-	4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R00888	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
k59_1420556_2	711393.AYRX01000082_gene4896	1.12e-21	95.5	COG0624@1|root,COG0624@2|Bacteria,2GKKW@201174|Actinobacteria	201174|Actinobacteria	E	COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
k59_1476846_1	1382356.JQMP01000001_gene818	1.05e-80	266.0	COG0060@1|root,COG0060@2|Bacteria,2G5SN@200795|Chloroflexi,27XEH@189775|Thermomicrobia	189775|Thermomicrobia	J	Anticodon-binding domain of tRNA	-	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
k59_586146_1	379066.GAU_1376	4.54e-89	272.0	COG2070@1|root,COG2070@2|Bacteria,1ZUN8@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Nitronate monooxygenase	-	-	1.13.12.16	ko:K00459	ko00910,map00910	-	R00025	RC02541,RC02759	ko00000,ko00001,ko01000	-	-	-	NMO
k59_1368121_1	926569.ANT_20510	3.55e-107	320.0	COG1304@1|root,COG1304@2|Bacteria,2G5RF@200795|Chloroflexi	200795|Chloroflexi	H	Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)	fni	-	5.3.3.2	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123	RC00455	ko00000,ko00001,ko00002,ko01000	-	-	-	FMN_dh
k59_1534206_1	1168065.DOK_07629	4.88e-35	127.0	COG0517@1|root,COG0517@2|Bacteria,1RJTX@1224|Proteobacteria,1S6K2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_1643940_1	221359.RS9916_30797	1.5e-55	196.0	COG0458@1|root,COG0458@2|Bacteria,1G00J@1117|Cyanobacteria,1GYRQ@1129|Synechococcus	1117|Cyanobacteria	F	Carbamoyl-phosphate synthetase ammonia chain	carB	GO:0000050,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_255171_1	443144.GM21_0106	2.19e-39	149.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42NEG@68525|delta/epsilon subdivisions,2WKHA@28221|Deltaproteobacteria,43TY6@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	actB	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_979860_1	234267.Acid_4577	5.3e-83	261.0	COG4993@1|root,COG4993@2|Bacteria,3Y696@57723|Acidobacteria	57723|Acidobacteria	G	PQQ-like domain	-	-	1.1.2.8	ko:K00114	ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130	-	R05062,R05198,R05285	RC00087,RC00088,RC01039	ko00000,ko00001,ko01000	-	-	-	PQQ_2
k59_925278_1	864069.MicloDRAFT_00011920	1.57e-25	101.0	COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,1JUUR@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	Integrase core domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
k59_1590435_1	1237149.C900_04947	0.000216	50.8	COG2931@1|root,COG3391@1|root,COG2931@2|Bacteria,COG3391@2|Bacteria,4NXDT@976|Bacteroidetes,47WEE@768503|Cytophagia	976|Bacteroidetes	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1755550_1	457425.XNR_0705	1.23e-07	58.5	COG0604@1|root,COG0604@2|Bacteria,2GMHR@201174|Actinobacteria	201174|Actinobacteria	C	alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
k59_33165_1	479434.Sthe_0960	1.44e-37	142.0	COG0464@1|root,COG0464@2|Bacteria,2G642@200795|Chloroflexi,27XW8@189775|Thermomicrobia	189775|Thermomicrobia	O	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_255199_1	543728.Vapar_0316	3.92e-96	294.0	COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,2VHPW@28216|Betaproteobacteria,4AABT@80864|Comamonadaceae	28216|Betaproteobacteria	P	TIGRFAM chromate transporter, chromate ion transporter (CHR) family	-	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
k59_33168_2	671143.DAMO_1316	0.000518	42.4	COG2204@1|root,COG2204@2|Bacteria,2NNWS@2323|unclassified Bacteria	2|Bacteria	T	Two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K07714,ko:K19641	ko02020,map02020	M00500,M00772	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_143838_1	331869.BAL199_17783	3.45e-38	145.0	COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,2TRF9@28211|Alphaproteobacteria,4BP85@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	P	Na+/Pi-cotransporter	MA20_30080	-	-	ko:K03324	-	-	-	-	ko00000,ko02000	2.A.58.2	-	-	Na_Pi_cotrans,PhoU
k59_255210_1	1216976.AX27061_5059	2.01e-61	202.0	COG3191@1|root,COG3191@2|Bacteria,1MWDP@1224|Proteobacteria,2VHM1@28216|Betaproteobacteria	28216|Betaproteobacteria	EQ	PFAM peptidase S58, DmpA	-	-	3.4.11.19	ko:K01266	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S58
k59_701632_1	1449357.JQLK01000001_gene277	8.5e-68	229.0	COG0567@1|root,COG0567@2|Bacteria,1WIKA@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	dehydrogenase e1 component	sucA	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
k59_1534254_1	391625.PPSIR1_18075	1.44e-47	172.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,42MER@68525|delta/epsilon subdivisions,2WIYV@28221|Deltaproteobacteria,2YW7P@29|Myxococcales	28221|Deltaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_88898_1	198467.NP92_13555	1.27e-54	186.0	COG1228@1|root,COG1228@2|Bacteria,1TP2J@1239|Firmicutes,4HAVY@91061|Bacilli,21VH2@150247|Anoxybacillus	91061|Bacilli	Q	Amidohydrolase family	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU39370	Amidohydro_1,Amidohydro_3
k59_1423298_1	926569.ANT_19800	1.97e-43	160.0	COG0210@1|root,COG0210@2|Bacteria,2G7VU@200795|Chloroflexi	200795|Chloroflexi	F	DNA helicase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_33189_1	1123065.ATWL01000002_gene1597	7.19e-45	158.0	COG2141@1|root,COG2141@2|Bacteria,2GM94@201174|Actinobacteria	201174|Actinobacteria	C	Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone	fgd	-	1.1.98.2	ko:K15510	-	-	-	-	ko00000,ko01000	-	-	-	Bac_luciferase
k59_366649_1	1179773.BN6_17390	4.95e-39	141.0	COG2897@1|root,COG2897@2|Bacteria,2GMDR@201174|Actinobacteria,4DYEN@85010|Pseudonocardiales	201174|Actinobacteria	P	Rhodanese-related sulfurtransferase	sseA	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
k59_480291_1	671143.DAMO_0701	1.5e-24	103.0	COG0500@1|root,COG2226@2|Bacteria,2NRU8@2323|unclassified Bacteria	2|Bacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,Methyltransf_31
k59_588856_1	65497.JODV01000007_gene361	1.68e-18	90.9	COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,4DYKC@85010|Pseudonocardiales	201174|Actinobacteria	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	GO:0000731,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0018130,GO:0019438,GO:0019985,GO:0030312,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042276,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:1901360,GO:1901362,GO:1901576	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_925327_2	1122176.KB903543_gene617	2.76e-35	130.0	COG0438@1|root,COG0438@2|Bacteria,4NFPA@976|Bacteroidetes,1IPP6@117747|Sphingobacteriia	976|Bacteroidetes	M	N-acetyl-alpha-D-glucosaminyl L-malate synthase	bshA	-	-	ko:K00754	-	-	-	-	ko00000,ko01000	-	GT4	-	Glyco_transf_4,Glycos_transf_1
k59_480294_1	345341.KUTG_00456	1.53e-40	143.0	COG3415@1|root,COG3415@2|Bacteria,2I2W7@201174|Actinobacteria,4EE1Z@85010|Pseudonocardiales	201174|Actinobacteria	L	Winged helix-turn helix	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_29,HTH_32
k59_255242_1	396588.Tgr7_0929	1.38e-17	84.3	COG0477@1|root,COG2814@2|Bacteria,1MVUF@1224|Proteobacteria,1RP39@1236|Gammaproteobacteria,1X2QU@135613|Chromatiales	135613|Chromatiales	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1479592_1	1111131.HMPREF1255_1131	2.38e-14	71.6	COG1716@1|root,COG1716@2|Bacteria,2GK99@201174|Actinobacteria,4DR1A@85009|Propionibacteriales	201174|Actinobacteria	T	zinc-ribbon domain	garA	-	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl,zinc_ribbon_2
k59_701668_1	1307436.PBF_05968	1.09e-24	106.0	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,4HA52@91061|Bacilli,1ZCQI@1386|Bacillus	91061|Bacilli	T	Histidine kinase	vicK	-	2.7.13.3	ko:K07652	ko02020,map02020	M00459	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_9
k59_979938_1	7213.XP_004532995.1	1.76e-23	103.0	COG0318@1|root,KOG1176@2759|Eukaryota	2759|Eukaryota	IQ	ligase activity	-	GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009820,GO:0009821,GO:0009987,GO:0017144,GO:0018130,GO:0018904,GO:0019748,GO:0034641,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044550,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1900794,GO:1900796,GO:1901334,GO:1901336,GO:1901360,GO:1901362,GO:1901503,GO:1901510,GO:1901512,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663	-	-	-	-	-	-	-	-	-	-	AMP-binding,PP-binding,Thioesterase
k59_366671_1	28532.XP_010550513.1	5.12e-52	177.0	COG0492@1|root,KOG0404@2759|Eukaryota,37HSP@33090|Viridiplantae,3GD2Q@35493|Streptophyta,3HVSX@3699|Brassicales	35493|Streptophyta	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	NTRB	GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005829,GO:0008150,GO:0008152,GO:0009507,GO:0009526,GO:0009536,GO:0009636,GO:0009941,GO:0009987,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0031967,GO:0031975,GO:0042221,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051302,GO:0051716,GO:0051781,GO:0055114,GO:0065007,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_701673_1	1123277.KB893182_gene4782	4.99e-67	215.0	COG0535@1|root,COG0535@2|Bacteria,4NFRX@976|Bacteroidetes,47KUF@768503|Cytophagia	976|Bacteroidetes	S	Protein of unknown function (DUF3641)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3641,Fer4_12,Radical_SAM
k59_422669_2	479432.Sros_4108	0.000248	42.4	COG0346@1|root,COG0346@2|Bacteria,2IM7G@201174|Actinobacteria	201174|Actinobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
k59_701679_1	1349785.BAUG01000025_gene1562	2.1e-64	208.0	COG3474@1|root,COG3474@2|Bacteria,4P242@976|Bacteroidetes,1I7HV@117743|Flavobacteriia	976|Bacteroidetes	C	Cytochrome P460	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_P460
k59_88954_1	1124780.ANNU01000072_gene1068	1.19e-24	108.0	COG2866@1|root,COG2866@2|Bacteria,4NEJA@976|Bacteroidetes,47KZ0@768503|Cytophagia	976|Bacteroidetes	E	PFAM Zinc carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
k59_480335_1	1411685.U062_02098	1.67e-23	107.0	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,1RNA6@1236|Gammaproteobacteria,1J4IV@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
k59_33244_1	378806.STAUR_3690	1.01e-73	240.0	COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,42P4Q@68525|delta/epsilon subdivisions,2WK5G@28221|Deltaproteobacteria,2YU4N@29|Myxococcales	28221|Deltaproteobacteria	O	Cytochrome c-type biogenesis protein	ccmF	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
k59_991950_1	504832.OCAR_5985	1.22e-22	95.9	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,2TRX2@28211|Alphaproteobacteria,3JSGG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs	rne	-	3.1.26.12	ko:K08300	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
k59_878817_1	926569.ANT_10860	1.6e-143	442.0	COG0086@1|root,COG0086@2|Bacteria,2G632@200795|Chloroflexi	200795|Chloroflexi	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_1325811_1	926550.CLDAP_16620	1.38e-53	186.0	COG0303@1|root,COG1910@1|root,COG0303@2|Bacteria,COG1910@2|Bacteria,2G64H@200795|Chloroflexi	200795|Chloroflexi	K	PBP superfamily domain	-	-	2.10.1.1	ko:K03750,ko:K07219	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	HTH_3,MoCF_biosynth,MoeA_C,MoeA_N,PBP_like
k59_991958_1	1249627.D779_4053	5.55e-26	105.0	COG3637@1|root,COG3637@2|Bacteria,1R3Z1@1224|Proteobacteria,1S22U@1236|Gammaproteobacteria,1X0RX@135613|Chromatiales	135613|Chromatiales	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1655961_1	861299.J421_0282	1.37e-31	130.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_1655961_2	240015.ACP_3516	7.11e-07	48.9	COG1695@1|root,COG1695@2|Bacteria,3Y55J@57723|Acidobacteria,2JJQ9@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
k59_714313_1	1283300.ATXB01000001_gene1698	6.46e-16	79.7	COG0711@1|root,COG0711@2|Bacteria,1R6C0@1224|Proteobacteria,1S5EV@1236|Gammaproteobacteria,1XGGZ@135618|Methylococcales	135618|Methylococcales	C	ATP synthase B/B' CF(0)	-	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
k59_1602359_1	1121097.JCM15093_789	0.000362	42.7	COG0381@1|root,COG0381@2|Bacteria,4NGBD@976|Bacteroidetes,2FNQP@200643|Bacteroidia,4AM7C@815|Bacteroidaceae	976|Bacteroidetes	M	Belongs to the UDP-N-acetylglucosamine 2-epimerase family	wecB	-	5.1.3.14	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase_2
k59_1602359_2	351016.RAZWK3B_12714	0.000197	47.4	COG0392@1|root,COG0392@2|Bacteria,1MVZ8@1224|Proteobacteria,2TTDM@28211|Alphaproteobacteria,2P3EJ@2433|Roseobacter	28211|Alphaproteobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	-	-	-	-	-	-	-	-	-	LPG_synthase_TM
k59_1048124_2	1340493.JNIF01000003_gene2146	1.82e-15	75.1	COG1595@1|root,COG1595@2|Bacteria,3Y589@57723|Acidobacteria	57723|Acidobacteria	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
k59_156169_1	240015.ACP_2524	2.95e-14	75.5	COG0348@1|root,COG3336@1|root,COG0348@2|Bacteria,COG3336@2|Bacteria,3Y3CM@57723|Acidobacteria,2JMJA@204432|Acidobacteriia	204432|Acidobacteriia	C	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG)	-	-	-	-	-	-	-	-	-	-	-	-	Caa3_CtaG
k59_1655998_1	204669.Acid345_0465	3.91e-75	253.0	COG0304@1|root,COG3321@1|root,COG4221@1|root,COG0304@2|Bacteria,COG3321@2|Bacteria,COG4221@2|Bacteria,3Y347@57723|Acidobacteria,2JHJH@204432|Acidobacteriia	204432|Acidobacteriia	Q	Ketoacyl-synthetase C-terminal extension	-	-	-	-	-	-	-	-	-	-	-	-	ADH_zinc_N,AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt
k59_600147_2	1122138.AQUZ01000031_gene4219	3.84e-08	56.6	COG0443@1|root,COG0443@2|Bacteria,2GJTY@201174|Actinobacteria,4DP1V@85009|Propionibacteriales	201174|Actinobacteria	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
k59_1271201_1	1205680.CAKO01000004_gene3631	5.64e-70	231.0	COG4231@1|root,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2TSHH@28211|Alphaproteobacteria,2JSZE@204441|Rhodospirillales	204441|Rhodospirillales	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	-	-	-	-	-	-	-	-	-	-	-	-	TPP_enzyme_C
k59_156170_1	1380356.JNIK01000014_gene3473	1.19e-80	255.0	COG2114@1|root,COG2197@1|root,COG2114@2|Bacteria,COG2197@2|Bacteria,2GJRI@201174|Actinobacteria,4EU4G@85013|Frankiales	201174|Actinobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,Response_reg
k59_44375_1	221288.JH992901_gene3913	1.36e-65	227.0	COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria,1JK4D@1189|Stigonemataceae	1117|Cyanobacteria	Q	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
k59_992010_1	2045.KR76_16865	4.41e-35	130.0	COG0500@1|root,COG2226@2|Bacteria,2HEKM@201174|Actinobacteria,4DNPK@85009|Propionibacteriales	201174|Actinobacteria	Q	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
k59_878876_1	404589.Anae109_2025	2.49e-107	329.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,42M80@68525|delta/epsilon subdivisions,2WINJ@28221|Deltaproteobacteria,2YUJ3@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
k59_1714791_1	204669.Acid345_1386	2.82e-30	114.0	2EDAV@1|root,33776@2|Bacteria,3Y8RG@57723|Acidobacteria,2JNHN@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1714791_2	1168289.AJKI01000036_gene3400	2.23e-29	118.0	2CESB@1|root,2Z8UZ@2|Bacteria,4NJSJ@976|Bacteroidetes	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1158819_1	861299.J421_2986	4.91e-86	270.0	COG0008@1|root,COG0008@2|Bacteria,1ZSSX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
k59_1380582_1	1123248.KB893318_gene4172	4.75e-14	71.2	COG0043@1|root,COG0043@2|Bacteria,4NHHV@976|Bacteroidetes,1IR14@117747|Sphingobacteriia	976|Bacteroidetes	H	Belongs to the UbiD family	-	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
k59_1271238_1	1279009.ADICEAN_01323	2.53e-65	214.0	COG1680@1|root,COG1680@2|Bacteria,4NFUI@976|Bacteroidetes,47MXY@768503|Cytophagia	976|Bacteroidetes	V	Beta-lactamase class C and other penicillin binding	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,DUF3471
k59_1380590_1	204669.Acid345_2962	8.08e-13	68.6	COG3051@1|root,COG3051@2|Bacteria	2|Bacteria	C	citrate CoA-transferase activity	citF	-	2.8.3.10	ko:K01643	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001,ko01000	-	-	-	CitF
k59_1158857_1	469383.Cwoe_4478	1.15e-14	78.6	COG1138@1|root,COG1138@2|Bacteria,2HZM9@201174|Actinobacteria,4CRCE@84995|Rubrobacteria	84995|Rubrobacteria	O	Cytochrome c-type biogenesis protein CcmF C-terminal	-	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
k59_767212_1	1121413.JMKT01000015_gene200	1.24e-09	64.3	COG0329@1|root,COG0329@2|Bacteria,1MUCM@1224|Proteobacteria,42M0X@68525|delta/epsilon subdivisions,2WK4D@28221|Deltaproteobacteria,2M7XK@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
k59_379137_1	69279.BG36_16285	4.89e-15	80.5	COG0673@1|root,COG0673@2|Bacteria,1PE0Y@1224|Proteobacteria,2V8CR@28211|Alphaproteobacteria,43QAI@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_1048173_1	926569.ANT_11950	9.28e-30	119.0	COG0646@1|root,COG0685@1|root,COG0646@2|Bacteria,COG0685@2|Bacteria,2G674@200795|Chloroflexi	200795|Chloroflexi	H	Homocysteine S-methyltransferase	-	-	1.5.1.20,2.1.1.10	ko:K00297,ko:K00547	ko00270,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01523,map00270,map00670,map00720,map01100,map01110,map01120,map01200,map01523	M00377	R00650,R01224,R07168	RC00003,RC00035,RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR,S-methyl_trans
k59_938061_1	34007.IT40_03975	1.29e-07	53.1	COG1062@1|root,COG1062@2|Bacteria,1R69M@1224|Proteobacteria,2U2AE@28211|Alphaproteobacteria,2PYJW@265|Paracoccus	28211|Alphaproteobacteria	C	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.1,1.1.1.284	ko:K00121	ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_938061_2	1380394.JADL01000004_gene5920	1.62e-53	184.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2TSME@28211|Alphaproteobacteria,2JQW6@204441|Rhodospirillales	204441|Rhodospirillales	E	Gamma-glutamyltranspeptidase	-	-	-	-	-	-	-	-	-	-	-	-	G_glu_transpept
k59_44408_1	1047013.AQSP01000142_gene193	3.75e-25	105.0	COG0534@1|root,COG0534@2|Bacteria,2NPFE@2323|unclassified Bacteria	2|Bacteria	V	Mate efflux family protein	-	-	-	-	-	-	-	-	-	-	-	-	ANKH,MatE
k59_44408_2	234267.Acid_7087	1.17e-49	177.0	COG1680@1|root,COG1680@2|Bacteria,3Y6F4@57723|Acidobacteria	57723|Acidobacteria	V	PFAM Beta-lactamase	-	-	3.4.16.4	ko:K18988	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Beta-lactamase,DUF3471
k59_1770432_1	448385.sce5442	1.27e-135	396.0	COG3191@1|root,COG3191@2|Bacteria,1MWDP@1224|Proteobacteria,42YEF@68525|delta/epsilon subdivisions,2WU92@28221|Deltaproteobacteria,2YYRX@29|Myxococcales	28221|Deltaproteobacteria	E	Peptidase family S58	dmpA	-	3.4.11.19	ko:K01266	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S58
k59_159028_2	1415780.JPOG01000001_gene3065	3.15e-10	56.6	2DNYP@1|root,32ZTI@2|Bacteria,1N747@1224|Proteobacteria,1SCCQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF2905)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2905
k59_548191_1	518766.Rmar_2509	8.24e-17	79.7	COG0812@1|root,COG0812@2|Bacteria,4PEBS@976|Bacteroidetes,1FISG@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	M	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
k59_328058_2	1223521.BBJX01000002_gene2860	1.05e-17	85.5	COG0843@1|root,COG0843@2|Bacteria,1R57U@1224|Proteobacteria,2VJ1N@28216|Betaproteobacteria,4AHFT@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM Cytochrome c oxidase, subunit I	cbaA	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_602410_1	926569.ANT_29800	3.13e-79	248.0	COG0621@1|root,COG0621@2|Bacteria,2G5QK@200795|Chloroflexi	200795|Chloroflexi	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
k59_1105045_1	1247963.JPHU01000001_gene2107	7e-64	211.0	COG1228@1|root,COG1228@2|Bacteria,1R40Z@1224|Proteobacteria,2U85Z@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_602415_1	1414720.CBYM010000004_gene146	1.24e-08	63.9	COG1574@1|root,COG1574@2|Bacteria,1TQ6G@1239|Firmicutes,24A5F@186801|Clostridia,36DJ1@31979|Clostridiaceae	186801|Clostridia	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_1770469_1	118173.KB235910_gene4799	1.52e-28	106.0	2CA6H@1|root,32RQP@2|Bacteria,1G86X@1117|Cyanobacteria,1HDCD@1150|Oscillatoriales	1117|Cyanobacteria	S	Protein of unknown function (DUF433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
k59_47011_1	926569.ANT_27540	9.04e-64	206.0	COG0460@1|root,COG0460@2|Bacteria,2G6PU@200795|Chloroflexi	200795|Chloroflexi	E	homoserine dehydrogenase	metM	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,Homoserine_dh,NAD_binding_3
k59_1717195_1	1454202.PPBDW_90765___1	3.35e-16	83.6	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1XSCN@135623|Vibrionales	135623|Vibrionales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1437990_1	649349.Lbys_1863	4.46e-31	122.0	COG1680@1|root,COG1680@2|Bacteria,4NER1@976|Bacteroidetes	976|Bacteroidetes	V	Beta-lactamase class C and other penicillin binding	-	-	3.4.16.4	ko:K01286	-	-	-	-	ko00000,ko01000	-	-	-	Beta-lactamase
k59_1717198_1	96561.Dole_2980	9.88e-05	49.7	COG0517@1|root,COG1993@1|root,COG0517@2|Bacteria,COG1993@2|Bacteria,1N0EM@1224|Proteobacteria,43BS4@68525|delta/epsilon subdivisions,2X72X@28221|Deltaproteobacteria,2MPVN@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Uncharacterized ACR, COG1993	-	-	-	-	-	-	-	-	-	-	-	-	CBS,DUF190
k59_657078_1	439235.Dalk_0710	1.21e-98	298.0	COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,42MEF@68525|delta/epsilon subdivisions,2WJ4D@28221|Deltaproteobacteria,2MI6F@213118|Desulfobacterales	28221|Deltaproteobacteria	E	PFAM aminotransferase class I and II	yfdZ	-	2.6.1.83	ko:K10206,ko:K14261	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_382200_1	1123278.KB893387_gene4377	5.54e-58	204.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,4NJWD@976|Bacteroidetes,47NJ1@768503|Cytophagia	976|Bacteroidetes	C	FAD linked oxidases, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_8
k59_1717204_1	118168.MC7420_3644	3.17e-12	63.9	COG1680@1|root,COG1680@2|Bacteria,1G4D0@1117|Cyanobacteria,1HFEP@1150|Oscillatoriales	1117|Cyanobacteria	V	PFAM beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_159097_2	65393.PCC7424_4201	1.45e-29	116.0	COG2244@1|root,COG2244@2|Bacteria,1GJ26@1117|Cyanobacteria,3KK3G@43988|Cyanothece	1117|Cyanobacteria	S	PFAM polysaccharide biosynthesis protein	-	-	-	ko:K03328	-	-	-	-	ko00000	2.A.66.2	-	-	Polysacc_synt_3
k59_103781_1	73501.XP_006674433.1	5.81e-06	50.8	COG3669@1|root,KOG3340@2759|Eukaryota,3A5J7@33154|Opisthokonta,3Q6F1@4751|Fungi,3QNP9@4890|Ascomycota,218QQ@147550|Sordariomycetes,3TMKX@5125|Hypocreales	4751|Fungi	G	Alpha-L-fucosidase	-	-	-	-	-	-	-	-	-	-	-	-	Alpha_L_fucos,F5_F8_type_C
k59_1438031_1	998674.ATTE01000001_gene623	4.17e-50	174.0	COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,1RN1D@1236|Gammaproteobacteria,45ZUG@72273|Thiotrichales	72273|Thiotrichales	J	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA	rlmD	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
k59_1604956_1	1336234.JAGN01000049_gene1069	3.09e-28	107.0	COG0698@1|root,COG0698@2|Bacteria,1V3HE@1239|Firmicutes,4HGXD@91061|Bacilli,27HE6@186828|Carnobacteriaceae	91061|Bacilli	G	Ribose/Galactose Isomerase	-	-	5.3.1.26,5.3.1.6	ko:K01808,ko:K01819	ko00030,ko00051,ko00052,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00052,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R03240,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
k59_1162260_1	395494.Galf_1309	8.47e-24	105.0	COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VJVN@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE5,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg,dCache_1
k59_826393_1	926569.ANT_08590	3.84e-80	254.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_1604980_1	477974.Daud_1778	1.78e-58	192.0	COG1086@1|root,COG1086@2|Bacteria,1TPTC@1239|Firmicutes,247YC@186801|Clostridia,261P4@186807|Peptococcaceae	186801|Clostridia	M	PFAM polysaccharide biosynthesis protein	pseB	-	4.2.1.115,5.1.3.2	ko:K15894,ko:K17716	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00362	R00291,R09697	RC00289,RC02609	ko00000,ko00001,ko00002,ko01000	-	-	-	Polysacc_synt_2
k59_382279_1	570952.ATVH01000017_gene1815	1.63e-59	188.0	COG0816@1|root,COG0816@2|Bacteria,1RDHZ@1224|Proteobacteria,2U98Y@28211|Alphaproteobacteria,2JSP7@204441|Rhodospirillales	204441|Rhodospirillales	L	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	-	-	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
k59_1050493_1	627192.SLG_25070	4.48e-38	143.0	COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,2TSB8@28211|Alphaproteobacteria,2K365@204457|Sphingomonadales	204457|Sphingomonadales	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
k59_1770563_1	298655.KI912267_gene7624	1.02e-12	68.6	COG2159@1|root,COG2159@2|Bacteria,2HG7W@201174|Actinobacteria,4EX8Y@85013|Frankiales	201174|Actinobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
k59_717753_2	926550.CLDAP_20100	5.86e-14	75.5	COG0723@1|root,COG0723@2|Bacteria,2G7BG@200795|Chloroflexi	200795|Chloroflexi	C	Rieske [2Fe-2S] domain	-	-	1.10.9.1	ko:K02636	ko00195,ko01100,map00195,map01100	M00162	R03817,R08409	RC01002	ko00000,ko00001,ko00002,ko00194,ko01000	-	-	-	Rieske
k59_1547339_1	998088.B565_3636	5.6e-33	129.0	COG1757@1|root,COG1757@2|Bacteria,1MVDF@1224|Proteobacteria,1RS40@1236|Gammaproteobacteria,1Y56B@135624|Aeromonadales	135624|Aeromonadales	C	Na+/H+ antiporter family	-	-	-	ko:K03315	-	-	-	-	ko00000,ko02000	2.A.35	-	-	Na_H_antiporter
k59_882398_1	693986.MOC_5254	2.39e-37	139.0	COG0696@1|root,COG0696@2|Bacteria,1MUQ1@1224|Proteobacteria,2TS6R@28211|Alphaproteobacteria,1JSPJ@119045|Methylobacteriaceae	28211|Alphaproteobacteria	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmI	-	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,Phosphodiest,iPGM_N
k59_882398_2	1449065.JMLL01000010_gene1210	1.38e-18	83.2	COG0289@1|root,COG0289@2|Bacteria,1MUCT@1224|Proteobacteria,2TSFJ@28211|Alphaproteobacteria,43HWJ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
k59_212331_1	1379270.AUXF01000004_gene3355	4.36e-20	88.6	COG1363@1|root,COG1363@2|Bacteria,1ZTF5@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	M42 glutamyl aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
k59_328231_1	338969.Rfer_2741	3.73e-26	108.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria	28216|Betaproteobacteria	T	response regulator	-	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_328231_2	1049564.TevJSym_aa00960	4.69e-29	117.0	COG0642@1|root,COG0834@1|root,COG0642@2|Bacteria,COG0834@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1J4Y6@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	COG0642 Signal transduction histidine kinase	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	CHASE,GAF,GAF_2,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,SBP_bac_3
k59_328231_3	1122612.AUBA01000012_gene641	1.19e-12	69.7	COG0642@1|root,COG1352@1|root,COG2201@1|root,COG4566@1|root,COG1352@2|Bacteria,COG2201@2|Bacteria,COG2205@2|Bacteria,COG4566@2|Bacteria,1NRP8@1224|Proteobacteria,2TWP9@28211|Alphaproteobacteria,2KETS@204457|Sphingomonadales	204457|Sphingomonadales	T	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	CheB_methylest,CheR,CheR_N,GerE,HATPase_c,HisKA,PAS_10,Response_reg
k59_508702_1	1207063.P24_08374	2.22e-15	80.9	COG2270@1|root,COG2270@2|Bacteria,1QVPF@1224|Proteobacteria,2TWJC@28211|Alphaproteobacteria,2JZ05@204441|Rhodospirillales	204441|Rhodospirillales	S	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
k59_953370_2	479434.Sthe_1300	1.74e-10	62.4	COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,2G5K6@200795|Chloroflexi,27Y1W@189775|Thermomicrobia	189775|Thermomicrobia	L	Helix-hairpin-helix domain	-	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_thumb,HHH_5,HHH_8,PHP
k59_1175820_1	479433.Caci_1407	3.84e-29	112.0	COG2884@1|root,COG2884@2|Bacteria,2GJE1@201174|Actinobacteria	201174|Actinobacteria	D	cell division ATP-binding protein FtsE	ftsE	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030145,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
k59_1175820_2	743719.PaelaDRAFT_5128	0.00026	42.7	COG1186@1|root,COG1186@2|Bacteria,1TPSB@1239|Firmicutes,4H9N2@91061|Bacilli,26SKW@186822|Paenibacillaceae	91061|Bacilli	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
k59_1509432_1	765420.OSCT_2904	9.51e-52	183.0	COG0607@1|root,COG0659@1|root,COG0607@2|Bacteria,COG0659@2|Bacteria,2G83D@200795|Chloroflexi,3764C@32061|Chloroflexia	32061|Chloroflexia	P	Sulfate permease family	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	Rhodanese,STAS,Sulfate_transp
k59_1009250_1	1218075.BAYA01000018_gene4723	5.15e-71	226.0	COG1063@1|root,COG1063@2|Bacteria,1MXHK@1224|Proteobacteria,2VZGT@28216|Betaproteobacteria,1K23A@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
k59_175093_1	1304865.JAGF01000001_gene1307	8.37e-62	201.0	COG0492@1|root,COG0492@2|Bacteria,2GKD2@201174|Actinobacteria,4F1AI@85016|Cellulomonadaceae	201174|Actinobacteria	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_1398258_1	756272.Plabr_0531	1.21e-61	201.0	COG1087@1|root,COG1087@2|Bacteria,2J4XM@203682|Planctomycetes	203682|Planctomycetes	M	Male sterility protein	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
k59_175114_1	637390.AFOH01000136_gene1799	3.65e-06	50.4	COG1595@1|root,COG1595@2|Bacteria,1R9WC@1224|Proteobacteria,1SA30@1236|Gammaproteobacteria,2ND7J@225057|Acidithiobacillales	225057|Acidithiobacillales	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r4_2
k59_619774_1	314278.NB231_16473	5.49e-97	310.0	COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,1MVKX@1224|Proteobacteria,1RMSH@1236|Gammaproteobacteria,1WY9K@135613|Chromatiales	135613|Chromatiales	G	alpha amylase catalytic	-	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Malt_amylase_C
k59_1064609_1	204536.SULAZ_1567	5.53e-58	193.0	COG0416@1|root,COG0416@2|Bacteria,2G3IE@200783|Aquificae	200783|Aquificae	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
k59_564089_1	261292.Nit79A3_3470	7.03e-26	102.0	COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,2VHSG@28216|Betaproteobacteria,3722G@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
k59_564089_2	1123367.C666_02465	2.01e-56	182.0	COG0052@1|root,COG0052@2|Bacteria,1MU33@1224|Proteobacteria,2VI8V@28216|Betaproteobacteria,2KUV5@206389|Rhodocyclales	206389|Rhodocyclales	J	Belongs to the universal ribosomal protein uS2 family	rpsB	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
k59_1120719_1	414684.RC1_2188	2.98e-125	362.0	COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,2TQKB@28211|Alphaproteobacteria,2JPJ9@204441|Rhodospirillales	204441|Rhodospirillales	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
k59_508759_1	379066.GAU_2029	1.14e-36	135.0	COG3375@1|root,COG3375@2|Bacteria,1ZUBU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	carboxylic acid catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_786858_2	66874.JOFS01000012_gene4729	0.000461	42.4	COG2057@1|root,COG2057@2|Bacteria,2GMA1@201174|Actinobacteria	201174|Actinobacteria	I	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit	-	-	-	-	-	-	-	-	-	-	-	-	CoA_trans
k59_1509489_1	379066.GAU_2370	4.15e-44	152.0	COG0704@1|root,COG0704@2|Bacteria	2|Bacteria	P	negative regulation of phosphate transmembrane transport	phoU	GO:0000287,GO:0001558,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006873,GO:0006950,GO:0007154,GO:0008150,GO:0009266,GO:0009267,GO:0009268,GO:0009405,GO:0009408,GO:0009605,GO:0009628,GO:0009892,GO:0009987,GO:0009991,GO:0010468,GO:0010563,GO:0010605,GO:0010629,GO:0010966,GO:0016020,GO:0016036,GO:0019220,GO:0019222,GO:0019725,GO:0019897,GO:0019898,GO:0022898,GO:0030002,GO:0030145,GO:0030320,GO:0030643,GO:0031323,GO:0031324,GO:0031667,GO:0031668,GO:0031669,GO:0032409,GO:0032410,GO:0032412,GO:0032413,GO:0032879,GO:0033554,GO:0034605,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0040008,GO:0042221,GO:0042592,GO:0042594,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043269,GO:0043271,GO:0044070,GO:0044092,GO:0044419,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045936,GO:0046677,GO:0046872,GO:0046914,GO:0046983,GO:0048519,GO:0048523,GO:0048878,GO:0050789,GO:0050794,GO:0050801,GO:0050896,GO:0051049,GO:0051051,GO:0051128,GO:0051174,GO:0051704,GO:0051716,GO:0055062,GO:0055081,GO:0055082,GO:0055083,GO:0060255,GO:0065007,GO:0065008,GO:0065009,GO:0070887,GO:0071214,GO:0071236,GO:0071467,GO:0071496,GO:0071944,GO:0072501,GO:0072502,GO:0072505,GO:0072506,GO:0098771,GO:0104004,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
k59_731485_1	1384054.N790_02435	8.47e-13	67.4	COG0209@1|root,COG0209@2|Bacteria,1P4EH@1224|Proteobacteria,1RP1A@1236|Gammaproteobacteria,1X3FG@135614|Xanthomonadales	135614|Xanthomonadales	F	COG0209 Ribonucleotide reductase, alpha subunit	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_731485_2	1415778.JQMM01000001_gene1049	2.3e-55	189.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,1RQUR@1236|Gammaproteobacteria,1J54K@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdZ	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Intein_splicing,LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN
k59_1565065_2	1121440.AUMA01000005_gene2706	7.63e-17	80.5	COG0388@1|root,COG0388@2|Bacteria,1MXG5@1224|Proteobacteria,42M1Y@68525|delta/epsilon subdivisions,2WIPE@28221|Deltaproteobacteria,2M92S@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	aguB	-	3.5.1.53	ko:K12251	ko00330,ko01100,map00330,map01100	-	R01152	RC00096	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
k59_1565074_1	760192.Halhy_1193	6.66e-41	146.0	COG2010@1|root,COG2010@2|Bacteria,4NHQV@976|Bacteroidetes,1IXTS@117747|Sphingobacteriia	976|Bacteroidetes	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
k59_453472_1	483219.LILAB_10280	1.26e-89	278.0	COG0006@1|root,COG0006@2|Bacteria,1MVHD@1224|Proteobacteria	1224|Proteobacteria	E	Xaa-Pro aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M24
k59_1342662_1	1173020.Cha6605_3073	2.1e-33	128.0	COG1132@1|root,COG1132@2|Bacteria,1G0C0@1117|Cyanobacteria	1117|Cyanobacteria	V	ABC-type multidrug transport system ATPase and permease	-	-	-	ko:K06147,ko:K06148	-	-	-	-	ko00000,ko02000	3.A.1,3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_tran
k59_1342662_2	588932.JHOF01000004_gene2631	2.38e-06	50.8	COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,2TR6F@28211|Alphaproteobacteria,2KFJ2@204458|Caulobacterales	204458|Caulobacterales	H	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppc	-	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase
k59_119360_1	1211115.ALIQ01000199_gene535	4.98e-68	224.0	COG0189@1|root,COG0454@1|root,COG0189@2|Bacteria,COG0456@2|Bacteria,1MVN2@1224|Proteobacteria,2TUT9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	HJ	Cyanophycin synthetase	cphA	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Dala_Dala_lig_C,GSH-S_ATP,RimK
k59_1232541_1	330214.NIDE4278	4.2e-62	198.0	2DC00@1|root,2ZC4V@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_8710_1	525904.Tter_0836	8.91e-22	95.1	COG0466@1|root,COG0466@2|Bacteria,2NNNN@2323|unclassified Bacteria	2|Bacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_8710_2	99598.Cal7507_4783	1.49e-27	110.0	COG3437@1|root,COG3437@2|Bacteria,1G2ZH@1117|Cyanobacteria,1HK6V@1161|Nostocales	1117|Cyanobacteria	T	Response regulator receiver domain	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD,HD_5,Response_reg
k59_786915_1	326442.PSHAa2366	2.8e-17	86.3	COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,1RNQD@1236|Gammaproteobacteria,2Q0RY@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006725,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008614,GO:0008615,GO:0008654,GO:0008661,GO:0009058,GO:0009108,GO:0009110,GO:0009228,GO:0009240,GO:0009987,GO:0016740,GO:0016744,GO:0017144,GO:0018130,GO:0019288,GO:0019438,GO:0019637,GO:0019682,GO:0019752,GO:0019842,GO:0030976,GO:0032787,GO:0034641,GO:0036094,GO:0042180,GO:0042181,GO:0042364,GO:0042723,GO:0042724,GO:0042816,GO:0042819,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046490,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:1901135,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663,GO:1901681	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	iEcSMS35_1347.EcSMS35_0456,iJN746.PP_0527	DXP_synthase_N,Transket_pyr,Transketolase_C
k59_619857_1	309801.trd_1309	1.64e-34	129.0	COG0476@1|root,COG0607@1|root,COG0476@2|Bacteria,COG0607@2|Bacteria,2G5TN@200795|Chloroflexi,27YS0@189775|Thermomicrobia	189775|Thermomicrobia	HP	ThiF family	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese,ThiF
k59_898374_1	1218075.BAYA01000013_gene3818	1.27e-71	226.0	COG3384@1|root,COG3384@2|Bacteria,1R6R4@1224|Proteobacteria,2W1RP@28216|Betaproteobacteria,1K5YM@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Catalytic LigB subunit of aromatic ring-opening dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	LigB
k59_397606_1	518766.Rmar_0343	9e-05	50.1	COG0840@1|root,COG3292@1|root,COG0840@2|Bacteria,COG3292@2|Bacteria,4NK8Q@976|Bacteroidetes	976|Bacteroidetes	T	Two component regulator propeller	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GerE,HATPase_c,Reg_prop,SpoIIE,Y_Y_Y
k59_564166_1	1183438.GKIL_3395	8.04e-72	240.0	COG0515@1|root,COG0515@2|Bacteria,1G3GV@1117|Cyanobacteria	1183438.GKIL_3395|-	T	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	-
k59_397609_1	656024.FsymDg_1953	4.48e-83	260.0	COG0069@1|root,COG0069@2|Bacteria,2GME2@201174|Actinobacteria,4ESBJ@85013|Frankiales	201174|Actinobacteria	E	Belongs to the glutamate synthase family	gltB_1	-	1.4.7.1	ko:K00284	ko00630,ko00910,ko01120,map00630,map00910,map01120	-	R00021,R10086	RC00006,RC00010	ko00000,ko00001,ko01000	-	-	-	Glu_synthase
k59_1175947_1	1306990.BARG01000061_gene6893	7.96e-28	115.0	COG0582@1|root,COG0582@2|Bacteria,2GISN@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_3,Phage_integrase
k59_453525_1	1192034.CAP_2781	7.96e-06	53.9	COG0515@1|root,COG3899@1|root,COG4191@1|root,COG0515@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,43BKN@68525|delta/epsilon subdivisions,2WJNS@28221|Deltaproteobacteria,2YXZU@29|Myxococcales	28221|Deltaproteobacteria	KLT	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GAF,HATPase_c,HisKA,Pkinase
k59_842178_1	448385.sce0379	9.16e-78	258.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,42N8M@68525|delta/epsilon subdivisions,2WJRT@28221|Deltaproteobacteria,2YUBZ@29|Myxococcales	28221|Deltaproteobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdA1	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_2_N,Ribonuc_red_lgC
k59_1731844_1	1395571.TMS3_0107105	1.52e-14	74.7	COG0398@1|root,COG0398@2|Bacteria,1RBAE@1224|Proteobacteria,1S32X@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function, DUF547	-	-	-	-	-	-	-	-	-	-	-	-	DUF547
k59_786949_1	247634.GPB2148_968	3.98e-07	57.0	COG3119@1|root,COG3119@2|Bacteria,1PFKU@1224|Proteobacteria,1S01U@1236|Gammaproteobacteria,1J98M@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
k59_8748_1	643473.KB235930_gene1962	2.31e-83	278.0	COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria,1HKNU@1161|Nostocales	1117|Cyanobacteria	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,Methyltransf_12,PP-binding,Thioesterase
k59_1509584_1	1274.HX89_03730	6.88e-78	243.0	COG0050@1|root,COG0050@2|Bacteria,2GK4T@201174|Actinobacteria,1ZVEV@145357|Dermacoccaceae	201174|Actinobacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	GO:0001666,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0008150,GO:0009628,GO:0010035,GO:0010038,GO:0010039,GO:0016020,GO:0019899,GO:0030312,GO:0035375,GO:0036293,GO:0040007,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070482,GO:0071944	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
k59_898423_2	861299.J421_2697	2.05e-37	141.0	COG0419@1|root,COG0419@2|Bacteria,1ZTD9@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	AAA domain	-	-	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	SMC_N
k59_341875_1	586416.GZ22_15135	8.18e-53	176.0	COG0421@1|root,COG0421@2|Bacteria,1TPG5@1239|Firmicutes,4H9WU@91061|Bacilli	91061|Bacilli	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	speE	GO:0003674,GO:0003824,GO:0004766,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0016740,GO:0016765,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU37500	Spermine_synt_N,Spermine_synth
k59_1398406_1	93220.LV28_10370	2.46e-35	134.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2VH8Z@28216|Betaproteobacteria,1JZW1@119060|Burkholderiaceae	28216|Betaproteobacteria	E	gamma-glutamyltransferase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k59_1398406_2	1208323.B30_08448	7.84e-24	100.0	COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	TRAP-type mannitol chloroaromatic compound transport system large permease component	dctM6	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_1620506_1	1123393.KB891316_gene1395	6.01e-55	181.0	COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,2VJ9D@28216|Betaproteobacteria,1KRH1@119069|Hydrogenophilales	119069|Hydrogenophilales	U	Peptidase S24-like	-	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
k59_843753_1	309801.trd_0750	5.29e-80	254.0	COG0034@1|root,COG0034@2|Bacteria,2G61T@200795|Chloroflexi,27XUW@189775|Thermomicrobia	189775|Thermomicrobia	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,Pribosyltran
k59_1400020_1	981336.F944_01180	5.08e-49	165.0	COG1651@1|root,COG1651@2|Bacteria,1RGWH@1224|Proteobacteria,1S5WA@1236|Gammaproteobacteria,3NJ0Z@468|Moraxellaceae	1236|Gammaproteobacteria	O	Thiol disulfide interchange protein	dsbA	-	-	ko:K03673	ko01503,map01503	M00728	-	-	ko00000,ko00001,ko00002,ko03110	-	-	-	DSBA
k59_510451_2	525904.Tter_0223	5.1e-31	121.0	COG0766@1|root,COG0766@2|Bacteria,2NNUV@2323|unclassified Bacteria	2|Bacteria	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
k59_10376_1	768671.ThimaDRAFT_2545	3.09e-95	288.0	COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,1RN4I@1236|Gammaproteobacteria,1WWZW@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	4.2.3.4	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03083	RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
k59_788759_1	1123228.AUIH01000046_gene1862	2.61e-31	123.0	COG1638@1|root,COG1638@2|Bacteria,1MVHI@1224|Proteobacteria,1S0YH@1236|Gammaproteobacteria,1XI7U@135619|Oceanospirillales	135619|Oceanospirillales	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_565913_1	926569.ANT_26040	3.07e-76	234.0	COG5433@1|root,COG5433@2|Bacteria,2G91G@200795|Chloroflexi	200795|Chloroflexi	L	DDE_Tnp_1-associated	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_assoc
k59_1622049_1	1158601.I585_01710	0.000324	50.4	COG1196@1|root,COG1196@2|Bacteria,1TPJV@1239|Firmicutes,4HB89@91061|Bacilli,4B07V@81852|Enterococcaceae	91061|Bacilli	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
k59_1066538_1	1458357.BG58_08920	3.07e-22	100.0	COG1804@1|root,COG1804@2|Bacteria,1PJ8V@1224|Proteobacteria,2W6WK@28216|Betaproteobacteria,1KD0K@119060|Burkholderiaceae	28216|Betaproteobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_677677_1	671143.DAMO_1652	6.66e-09	57.8	COG2825@1|root,COG2825@2|Bacteria,2NQ6C@2323|unclassified Bacteria	2|Bacteria	M	Outer membrane protein (OmpH-like)	ompH	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
k59_677677_2	888062.HMPREF9083_0247	2.01e-05	49.7	COG4775@1|root,COG4775@2|Bacteria,1UMDS@1239|Firmicutes,4H27F@909932|Negativicutes	909932|Negativicutes	M	Outer membrane protein, OMP85 family	yaeT	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
k59_1122672_2	768704.Desmer_1602	1.29e-16	78.2	COG4816@1|root,COG4816@2|Bacteria,1TPAQ@1239|Firmicutes,248W6@186801|Clostridia,261BX@186807|Peptococcaceae	186801|Clostridia	E	PFAM BMC domain	eutL	-	-	ko:K04026	-	-	-	-	ko00000	-	-	-	BMC
k59_1288826_1	1235457.C404_16505	5.94e-89	286.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,2VJG2@28216|Betaproteobacteria,1K5NF@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	fdhA	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_1234484_2	1123234.AUKI01000019_gene552	1.22e-21	94.0	28KH6@1|root,2ZA2R@2|Bacteria,4NI7X@976|Bacteroidetes,1HYH8@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_510480_1	765913.ThidrDRAFT_2395	1.64e-66	225.0	COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,1RPRP@1236|Gammaproteobacteria,1WYM2@135613|Chromatiales	135613|Chromatiales	S	penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
k59_1177780_1	929562.Emtol_3067	2.04e-28	107.0	2DMPT@1|root,32SXV@2|Bacteria,4PKGT@976|Bacteroidetes,47R1K@768503|Cytophagia	976|Bacteroidetes	S	Domain of unknown function (DUF3127)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3127
k59_1066557_2	313628.LNTAR_08699	5.72e-06	50.1	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
k59_121151_1	479433.Caci_0917	1.55e-70	238.0	COG0085@1|root,COG0085@2|Bacteria,2GJ81@201174|Actinobacteria	201174|Actinobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0030880,GO:0032991,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0061695,GO:0071944,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_1177790_1	1089551.KE386572_gene4544	2.81e-29	117.0	COG0438@1|root,COG0438@2|Bacteria,1RH5W@1224|Proteobacteria,2V854@28211|Alphaproteobacteria,4BSTB@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
k59_1122695_1	1517416.IDAT_02720	4.84e-17	80.1	COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,1RMWK@1236|Gammaproteobacteria,2QF1W@267893|Idiomarinaceae	1236|Gammaproteobacteria	V	Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner	lolD	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0015399,GO:0015405,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0034613,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0051179,GO:0051234,GO:0051641,GO:0055085,GO:0070727,GO:0071944,GO:0072657,GO:0089705,GO:0097159,GO:0097367,GO:0098796,GO:0098797,GO:1901265,GO:1901363,GO:1990778	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
k59_843811_1	1209072.ALBT01000034_gene1763	2.22e-32	129.0	COG3642@1|root,COG3642@2|Bacteria,1R7MU@1224|Proteobacteria,1RRK2@1236|Gammaproteobacteria,1FGXR@10|Cellvibrio	1236|Gammaproteobacteria	T	Lipopolysaccharide kinase (Kdo/WaaP) family	-	-	-	-	-	-	-	-	-	-	-	-	Kdo
k59_1234504_2	1450694.BTS2_2640	3.84e-15	78.2	COG0501@1|root,COG0501@2|Bacteria,1TP23@1239|Firmicutes,4HB11@91061|Bacilli,1ZE4S@1386|Bacillus	91061|Bacilli	O	Peptidase family M48	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
k59_1234506_1	861299.J421_4099	5.55e-35	137.0	COG0577@1|root,COG0577@2|Bacteria	861299.J421_4099|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_621535_1	491952.Mar181_2574	7.98e-94	282.0	COG2041@1|root,COG2041@2|Bacteria,1MUW0@1224|Proteobacteria,1RQ2J@1236|Gammaproteobacteria,1XHX5@135619|Oceanospirillales	135619|Oceanospirillales	C	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide	msrP	-	-	ko:K07147	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_molyb
k59_677717_2	40149.OMERI10G11590.1	7.73e-19	89.0	COG0281@1|root,KOG1257@2759|Eukaryota,37NY1@33090|Viridiplantae,3GDGG@35493|Streptophyta,3KXVF@4447|Liliopsida,3I4W9@38820|Poales	35493|Streptophyta	C	malic enzyme	-	GO:0000166,GO:0003674,GO:0003824,GO:0004470,GO:0004471,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006090,GO:0006108,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009507,GO:0009536,GO:0009987,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0017076,GO:0019752,GO:0030554,GO:0031974,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0035639,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043648,GO:0044237,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0046983,GO:0050897,GO:0055114,GO:0070013,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363	1.1.1.39	ko:K00028	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00171	R00214	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,malic
k59_900290_1	926569.ANT_06300	1.65e-41	146.0	COG1682@1|root,COG1682@2|Bacteria,2G7UW@200795|Chloroflexi	200795|Chloroflexi	GM	PFAM ABC-2 type transporter	-	-	-	ko:K09690	ko02010,map02010	M00250	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.103	-	-	ABC2_membrane
k59_1344374_1	671143.DAMO_2645	1.39e-81	264.0	COG0751@1|root,COG0751@2|Bacteria,2NNWY@2323|unclassified Bacteria	2|Bacteria	J	Glycyl-tRNA synthetase beta subunit	glyS	GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046983,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.14	ko:K01879,ko:K14164	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAPECO1_1312.APECO1_2891,iE2348C_1286.E2348C_3810,iECABU_c1320.ECABU_c40010,iECED1_1282.ECED1_4242,iECH74115_1262.ECH74115_4934,iECNA114_1301.ECNA114_3710,iECOK1_1307.ECOK1_4005,iECP_1309.ECP_3661,iECS88_1305.ECS88_3976,iECSF_1327.ECSF_3393,iECSP_1301.ECSP_4554,iECs_1301.ECs4442,iG2583_1286.G2583_4300,iJN678.glyS,iUMN146_1321.UM146_17960,iUTI89_1310.UTI89_C4099,ic_1306.c4378	DALR_1,tRNA_synt_2f
k59_455262_1	861299.J421_3753	3.34e-59	194.0	COG1940@1|root,COG1940@2|Bacteria,1ZT66@142182|Gemmatimonadetes	142182|Gemmatimonadetes	GK	ROK family	-	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
k59_399468_1	251221.35211765	5.82e-12	68.6	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_306411_1	1231392.OCGS_0415	1.63e-05	53.9	COG0668@1|root,COG0668@2|Bacteria,1MXD2@1224|Proteobacteria,2TV7R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	mechanosensitive ion channel	-	-	-	ko:K16052,ko:K22044	-	-	-	-	ko00000,ko02000	1.A.23.3,1.A.23.4	-	-	MS_channel
k59_1030225_1	251229.Chro_4405	3.84e-76	254.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1146@2|Bacteria,1G2E2@1117|Cyanobacteria,3VJDV@52604|Pleurocapsales	1117|Cyanobacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	-	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_750597_1	479434.Sthe_0784	2.82e-70	225.0	COG0498@1|root,COG0498@2|Bacteria,2G5RK@200795|Chloroflexi,27Y4R@189775|Thermomicrobia	189775|Thermomicrobia	E	Threonine synthase	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_1307220_2	383372.Rcas_1135	1.53e-12	67.4	COG0606@1|root,COG0606@2|Bacteria,2G65P@200795|Chloroflexi,37511@32061|Chloroflexia	32061|Chloroflexia	O	PFAM magnesium chelatase ChlI subunit	-	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
k59_1750551_1	1123392.AQWL01000006_gene570	1.12e-80	249.0	COG0451@1|root,COG0451@2|Bacteria,1MU7J@1224|Proteobacteria,2VI0M@28216|Betaproteobacteria,1KRB7@119069|Hydrogenophilales	119069|Hydrogenophilales	M	Polysaccharide biosynthesis protein	-	-	5.1.3.6	ko:K08679	ko00520,ko01100,map00520,map01100	-	R01385	RC00289	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
k59_973835_1	236097.ADG881_1747	6.94e-21	89.7	COG0835@1|root,COG0835@2|Bacteria,1RCIR@1224|Proteobacteria,1S61F@1236|Gammaproteobacteria,1XKR5@135619|Oceanospirillales	135619|Oceanospirillales	NT	Chemotaxis signal transduction protein	pilI	-	-	ko:K02659	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	CheW
k59_973835_2	314278.NB231_13331	2.3e-41	139.0	COG0745@1|root,COG0745@2|Bacteria,1RI9T@1224|Proteobacteria,1S5UT@1236|Gammaproteobacteria,1WYJQ@135613|Chromatiales	135613|Chromatiales	T	response regulator receiver	-	-	-	ko:K02658	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko02022,ko02035,ko02044	-	-	-	Response_reg
k59_583123_1	483219.LILAB_19540	1.33e-67	230.0	COG0642@1|root,COG3829@1|root,COG2205@2|Bacteria,COG3829@2|Bacteria,1NRP8@1224|Proteobacteria,42PS5@68525|delta/epsilon subdivisions,2X77E@28221|Deltaproteobacteria,2YYG0@29|Myxococcales	28221|Deltaproteobacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS_4,PAS_9,Response_reg
k59_1750567_1	243233.MCA1511	4.81e-47	167.0	COG0457@1|root,COG0859@1|root,COG0457@2|Bacteria,COG0859@2|Bacteria,1MUZK@1224|Proteobacteria,1S4C5@1236|Gammaproteobacteria,1XGYR@135618|Methylococcales	1236|Gammaproteobacteria	M	TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF29,Glyco_transf_9,TPR_1,TPR_16,TPR_19,TPR_2,TPR_8
k59_695914_1	316274.Haur_4569	8.74e-33	124.0	COG0045@1|root,COG0045@2|Bacteria,2G68A@200795|Chloroflexi,3758T@32061|Chloroflexia	32061|Chloroflexia	F	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
k59_695914_2	483219.LILAB_25695	7.34e-33	122.0	COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,42M2W@68525|delta/epsilon subdivisions,2WJBV@28221|Deltaproteobacteria,2YTTU@29|Myxococcales	28221|Deltaproteobacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,CoA_binding,Ligase_CoA
k59_1084478_1	379066.GAU_0585	2.98e-22	97.8	COG2148@1|root,COG2148@2|Bacteria,1ZSW2@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Bacterial sugar transferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf
k59_1528866_1	671143.DAMO_2631	1.26e-14	73.2	COG1463@1|root,COG1463@2|Bacteria,2NPXJ@2323|unclassified Bacteria	2|Bacteria	Q	MlaD protein	ttg2C	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
k59_638548_1	935866.JAER01000047_gene3925	0.000691	42.0	COG1989@1|root,COG1989@2|Bacteria,2GJ7K@201174|Actinobacteria,4DRTI@85009|Propionibacteriales	201174|Actinobacteria	NOU	Type IV leader peptidase family	pppA	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
k59_638548_2	1150864.MILUP08_42508	9.34e-55	183.0	COG0082@1|root,COG0082@2|Bacteria,2GJJN@201174|Actinobacteria,4DAFR@85008|Micromonosporales	201174|Actinobacteria	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016491,GO:0016651,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2540c	Chorismate_synt
k59_28039_1	1125863.JAFN01000001_gene1760	1.07e-33	128.0	COG3581@1|root,COG3581@2|Bacteria,1PDHS@1224|Proteobacteria,43DP1@68525|delta/epsilon subdivisions	1224|Proteobacteria	I	4 iron, 4 sulfur cluster binding	-	-	-	-	-	-	-	-	-	-	-	-	HGD-D
k59_138556_1	384765.SIAM614_01619	1.03e-107	326.0	COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,2TS6X@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
k59_138556_2	13689.BV96_02448	6.37e-64	210.0	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,2TTXT@28211|Alphaproteobacteria,2K2IC@204457|Sphingomonadales	204457|Sphingomonadales	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
k59_1030271_1	1121033.AUCF01000018_gene5833	4.33e-88	263.0	COG0307@1|root,COG0307@2|Bacteria,1MUMB@1224|Proteobacteria,2U3RS@28211|Alphaproteobacteria,2JR8K@204441|Rhodospirillales	204441|Rhodospirillales	H	Riboflavin synthase alpha chain	ribE	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
k59_28053_1	1121937.AUHJ01000055_gene1198	8.16e-95	280.0	COG0500@1|root,COG2226@2|Bacteria,1R2J9@1224|Proteobacteria,1T5R2@1236|Gammaproteobacteria,46BYA@72275|Alteromonadaceae	1236|Gammaproteobacteria	Q	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_2
k59_750649_1	926569.ANT_24960	5.46e-95	299.0	COG1472@1|root,COG1472@2|Bacteria,2G5S5@200795|Chloroflexi	200795|Chloroflexi	G	Fibronectin type III-like domain	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
k59_474324_1	1961.JOAK01000012_gene6014	4.16e-27	112.0	COG1960@1|root,COG1960@2|Bacteria,2GIX8@201174|Actinobacteria	201174|Actinobacteria	I	acyl-CoA dehydrogenase	fadE25	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_806381_1	290633.GOX2168	5.8e-24	95.5	COG0355@1|root,COG0355@2|Bacteria,1N0ZB@1224|Proteobacteria,2U9XA@28211|Alphaproteobacteria,2JU6Q@204441|Rhodospirillales	204441|Rhodospirillales	C	ATP synthase, Delta/Epsilon chain, beta-sandwich domain	-	-	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE_N
k59_806381_2	1157708.KB907463_gene800	4.15e-20	89.7	COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,2VHDZ@28216|Betaproteobacteria,4AAUZ@80864|Comamonadaceae	28216|Betaproteobacteria	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_83623_1	1035308.AQYY01000002_gene728	1.87e-48	160.0	COG0590@1|root,COG0590@2|Bacteria,1V3HZ@1239|Firmicutes,24JM2@186801|Clostridia,261UB@186807|Peptococcaceae	186801|Clostridia	FJ	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	-	3.5.4.33	ko:K11991	-	-	R10223	RC00477	ko00000,ko01000,ko03016	-	-	-	MafB19-deam
k59_1252810_1	557599.MKAN_20800	3.92e-41	156.0	COG2114@1|root,COG2197@1|root,COG3903@1|root,COG2114@2|Bacteria,COG2197@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,23D5I@1762|Mycobacteriaceae	201174|Actinobacteria	K	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Guanylate_cyc,NB-ARC
k59_528386_1	1122947.FR7_3785	8.96e-45	157.0	COG4214@1|root,COG4214@2|Bacteria,1VU1F@1239|Firmicutes,4H6NP@909932|Negativicutes	909932|Negativicutes	G	Branched-chain amino acid transport system / permease component	-	-	-	ko:K10547	ko02010,map02010	M00216	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.5	-	-	BPD_transp_2
k59_806389_2	469383.Cwoe_5866	4.26e-59	194.0	COG1488@1|root,COG1488@2|Bacteria,2GJAT@201174|Actinobacteria,4CQTG@84995|Rubrobacteria	84995|Rubrobacteria	H	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	-	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	Isochorismatase,QRPTase_C,QRPTase_N
k59_1140658_1	1140.Synpcc7942_1992	1.83e-47	164.0	COG0182@1|root,COG0182@2|Bacteria,1G2JX@1117|Cyanobacteria,1GZZC@1129|Synechococcus	1117|Cyanobacteria	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
k59_1528910_1	398580.Dshi_1449	7.28e-11	67.4	COG4772@1|root,COG4772@2|Bacteria,1MUIH@1224|Proteobacteria,2TRPJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	TonB-dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k59_1639052_1	98439.AJLL01000070_gene1485	6.7e-55	189.0	COG0843@1|root,COG0843@2|Bacteria,1G1ME@1117|Cyanobacteria,1JI9I@1189|Stigonemataceae	1117|Cyanobacteria	C	Cytochrome C and Quinol oxidase polypeptide I	ctaD	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_1584772_1	156889.Mmc1_1986	2.25e-54	186.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,2U1Z0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	reverse transcriptase	-	-	2.7.7.49	ko:K00986,ko:K15342	-	-	-	-	ko00000,ko01000,ko02048,ko03400	-	-	-	Cas_Cas1,GIIM,RVT_1
k59_28095_1	1123355.JHYO01000016_gene1905	2.72e-12	63.5	2EJSQ@1|root,33DHC@2|Bacteria,1NK83@1224|Proteobacteria,2UJRV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_28095_2	648757.Rvan_2289	6.39e-32	120.0	COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,2TQZP@28211|Alphaproteobacteria,3N6QM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	OU	Peptidase S49	sohB	-	-	ko:K04773,ko:K04774	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
k59_750689_1	318161.Sden_0973	2.16e-17	83.2	COG2819@1|root,COG2819@2|Bacteria,1RB1X@1224|Proteobacteria,1RY80@1236|Gammaproteobacteria,2QBJQ@267890|Shewanellaceae	1236|Gammaproteobacteria	S	Putative esterase	-	-	-	ko:K07017	-	-	-	-	ko00000	-	-	-	Esterase
k59_584956_1	675635.Psed_3921	5.66e-18	87.8	COG4638@1|root,COG4638@2|Bacteria,2HJQP@201174|Actinobacteria	2|Bacteria	P	Rieske [2Fe-2S] domain	-	-	-	ko:K15060	ko00627,ko01120,map00627,map01120	-	R09275	RC00392,RC01533	ko00000,ko00001	-	-	-	Rieske
k59_584975_1	671143.DAMO_3037	7.98e-82	259.0	COG0129@1|root,COG0129@2|Bacteria,2NNSM@2323|unclassified Bacteria	2|Bacteria	EG	Belongs to the IlvD Edd family	ilvD	GO:0003674,GO:0003824,GO:0004160,GO:0016829,GO:0016835,GO:0016836	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
k59_308327_1	861299.J421_3811	3.33e-38	145.0	COG1640@1|root,COG1640@2|Bacteria,1ZU23@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	4-alpha-glucanotransferase	-	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
k59_362876_1	211165.AJLN01000134_gene5860	0.000184	48.1	COG3240@1|root,COG4625@1|root,COG3240@2|Bacteria,COG4625@2|Bacteria,1G2WT@1117|Cyanobacteria,1JKJE@1189|Stigonemataceae	1117|Cyanobacteria	I	Autotransporter beta-domain	-	-	-	ko:K12686	-	-	-	-	ko00000,ko02000,ko02044	1.B.12.8	-	-	Autotransporter,Lipase_GDSL
k59_308330_1	1123508.JH636446_gene6253	4.12e-35	127.0	COG1801@1|root,COG1801@2|Bacteria,2IYWM@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
k59_1032351_1	1085623.GNIT_1528	3.44e-69	226.0	COG2067@1|root,COG2067@2|Bacteria,1PXPC@1224|Proteobacteria,1RQKS@1236|Gammaproteobacteria,466B6@72275|Alteromonadaceae	1236|Gammaproteobacteria	I	Protein of unknown function (DUF3570)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3570
k59_308333_1	443255.SCLAV_1159	1.52e-67	231.0	COG0178@1|root,COG0178@2|Bacteria,2GJUV@201174|Actinobacteria	201174|Actinobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	GO:0000018,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0045910,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0071944,GO:0080090	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_1032375_1	1303518.CCALI_01279	5.16e-15	77.0	COG4166@1|root,COG4166@2|Bacteria	2|Bacteria	E	transmembrane transport	-	-	-	ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
k59_1032375_2	130081.XP_005705094.1	4.68e-23	99.4	COG0436@1|root,KOG0257@2759|Eukaryota	2759|Eukaryota	E	transferase activity, transferring nitrogenous groups	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
k59_1086441_1	292459.STH1330	2.31e-43	152.0	COG0115@1|root,COG0115@2|Bacteria,1TPY2@1239|Firmicutes,25CC3@186801|Clostridia	186801|Clostridia	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	dat	-	2.6.1.21	ko:K00824	ko00310,ko00330,ko00360,ko00472,ko00473,ko01100,map00310,map00330,map00360,map00472,map00473,map01100	-	R01148,R01582,R02459,R02851,R02924,R05053	RC00006,RC00008,RC00025	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_4
k59_975957_1	1121875.KB907553_gene20	8.91e-52	178.0	COG5361@1|root,COG5361@2|Bacteria,4NKSK@976|Bacteroidetes,1IARY@117743|Flavobacteriia	976|Bacteroidetes	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_1309367_1	926550.CLDAP_34600	2.33e-51	178.0	COG2407@1|root,COG2407@2|Bacteria,2G8ER@200795|Chloroflexi	200795|Chloroflexi	G	Converts the aldose L-fucose into the corresponding ketose L-fuculose	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_140354_1	443598.AUFA01000002_gene2563	2.11e-39	145.0	COG2203@1|root,COG4191@1|root,COG5002@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,COG5002@2|Bacteria,1RCM9@1224|Proteobacteria,2TTJ0@28211|Alphaproteobacteria,3K6MV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Cache domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,dCache_1
k59_140354_2	1408224.SAMCCGM7_c6617	1.49e-32	115.0	COG3437@1|root,COG3437@2|Bacteria,1REES@1224|Proteobacteria,2U7TN@28211|Alphaproteobacteria,4BF65@82115|Rhizobiaceae	28211|Alphaproteobacteria	KT	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
k59_640387_1	570967.JMLV01000009_gene1024	2e-47	169.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TSG6@28211|Alphaproteobacteria,2JQUU@204441|Rhodospirillales	204441|Rhodospirillales	C	FAD linked oxidases, C-terminal domain	glcD	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_140377_1	309807.SRU_0709	1.41e-87	268.0	COG1063@1|root,COG1063@2|Bacteria,4NE11@976|Bacteroidetes,1FJZM@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	C	Alcohol dehydrogenase GroES-associated	yjmD_2	-	-	ko:K18369	ko00640,map00640	-	R10703	RC00545	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_N_assoc,ADH_zinc_N,ADH_zinc_N_2
k59_1086486_1	357809.Cphy_0430	1.7e-78	256.0	COG3459@1|root,COG3459@2|Bacteria,1TQY8@1239|Firmicutes,248YP@186801|Clostridia,21Y2R@1506553|Lachnoclostridium	186801|Clostridia	G	glycosyltransferase 36 associated	-	-	2.4.1.20,2.4.1.280	ko:K00702,ko:K18675	ko00500,ko00520,ko01100,map00500,map00520,map01100	-	R00952,R09942	RC00049	ko00000,ko00001,ko01000	-	GH94,GT36	-	Glyco_hydro_36,Glyco_transf_36
k59_1698769_1	1120792.JAFV01000001_gene3510	3.34e-111	339.0	COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,2TVYU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EQ	N-methylhydantoinase B acetone carboxylase alpha subunit	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
k59_976030_1	63737.Npun_F5679	1.7e-32	130.0	COG0515@1|root,COG0642@1|root,COG0745@1|root,COG2203@1|root,COG3899@1|root,COG0515@2|Bacteria,COG0745@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG3899@2|Bacteria,1G0GI@1117|Cyanobacteria	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GAF_3,HATPase_c,HisKA,PAS_3,PAS_9,Response_reg
k59_308409_1	1089546.AQUI01000002_gene3291	4.43e-56	186.0	COG1032@1|root,COG1032@2|Bacteria,2ISAI@201174|Actinobacteria	201174|Actinobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
k59_976038_2	1123371.ATXH01000014_gene1602	2.15e-65	209.0	COG0410@1|root,COG0410@2|Bacteria,2GIDS@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	E	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
k59_362964_1	194439.CT1683	7.47e-83	269.0	COG0474@1|root,COG0474@2|Bacteria	2|Bacteria	P	ATPase, P-type transporting, HAD superfamily, subfamily IC	-	-	3.6.3.2,3.6.3.6	ko:K01531,ko:K01535	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.3.3,3.A.3.4	-	-	Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k59_1032481_1	675635.Psed_1830	1.2e-96	302.0	COG0443@1|root,COG0443@2|Bacteria,2GNTE@201174|Actinobacteria,4E043@85010|Pseudonocardiales	201174|Actinobacteria	O	Hsp70 protein	-	-	-	-	-	-	-	-	-	-	-	-	HSP70
k59_196311_2	1379270.AUXF01000005_gene387	2.98e-68	213.0	COG0353@1|root,COG0353@2|Bacteria,1ZTJX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecR,Toprim_4
k59_752457_1	1379270.AUXF01000001_gene2312	2.06e-26	111.0	COG0076@1|root,COG0076@2|Bacteria,1ZSZN@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	4.1.1.105,4.1.1.28	ko:K01593	ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00037,M00042	R00685,R00699,R00736,R02080,R02701,R04909	RC00299	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyridoxal_deC
k59_1752395_1	671143.DAMO_2574	1.84e-62	201.0	COG1427@1|root,COG1427@2|Bacteria,2NRPR@2323|unclassified Bacteria	2|Bacteria	S	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnA	-	1.21.98.1,4.2.1.151	ko:K07081,ko:K11782,ko:K11784	ko00130,ko01110,map00130,map01110	-	R08588,R10666	RC02329,RC03232	ko00000,ko00001,ko01000	-	-	-	VitK2_biosynth
k59_1698832_1	237368.SCABRO_02138	1.11e-08	58.5	COG0664@1|root,COG0664@2|Bacteria,2J4FD@203682|Planctomycetes	203682|Planctomycetes	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
k59_1752406_1	1535422.ND16A_2591	5.61e-31	125.0	COG0845@1|root,COG0845@2|Bacteria,1R50D@1224|Proteobacteria,1RRYM@1236|Gammaproteobacteria,2Q7X5@267889|Colwelliaceae	1236|Gammaproteobacteria	M	Biotin-lipoyl like	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
k59_362992_1	926569.ANT_31260	2.01e-67	218.0	COG1109@1|root,COG1109@2|Bacteria,2G5PR@200795|Chloroflexi	200795|Chloroflexi	G	Phosphoglucomutase/phosphomannomutase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_640456_1	868864.Dester_0424	1.44e-20	90.5	COG0151@1|root,COG0151@2|Bacteria,2G3J3@200783|Aquificae	200783|Aquificae	F	Belongs to the GARS family	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
k59_640456_2	1386089.N865_11315	2.67e-26	102.0	COG0041@1|root,COG0041@2|Bacteria,2IFFD@201174|Actinobacteria,4FGF7@85021|Intrasporangiaceae	201174|Actinobacteria	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	GO:0008150,GO:0040007	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv3275c	AIRC
k59_1698841_1	204669.Acid345_3021	1.16e-15	81.6	COG4447@1|root,COG4447@2|Bacteria,3Y6ZR@57723|Acidobacteria	57723|Acidobacteria	M	Sortilin, neurotensin receptor 3,	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
k59_1530694_1	479434.Sthe_1400	3.36e-57	189.0	COG1319@1|root,COG1319@2|Bacteria,2G60Y@200795|Chloroflexi,27XP9@189775|Thermomicrobia	189775|Thermomicrobia	C	CO dehydrogenase flavoprotein C-terminal domain	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
k59_921606_1	1122925.KB895382_gene3677	1.76e-07	57.8	COG0760@1|root,COG0760@2|Bacteria,1UZZM@1239|Firmicutes,4HE14@91061|Bacilli,26RHI@186822|Paenibacillaceae	91061|Bacilli	O	peptidyl-prolyl isomerase	yacD	-	5.2.1.8	ko:K07533	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
k59_476570_1	768671.ThimaDRAFT_2470	4.25e-57	186.0	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,1RMSS@1236|Gammaproteobacteria,1WWP3@135613|Chromatiales	135613|Chromatiales	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
k59_476570_2	1267005.KB911266_gene1250	1.45e-19	86.7	COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,2TS6X@28211|Alphaproteobacteria,3N7U4@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Putative transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
k59_419210_1	485913.Krac_5027	3.85e-17	85.1	COG2909@1|root,COG3903@1|root,COG2909@2|Bacteria,COG3903@2|Bacteria,2G7SC@200795|Chloroflexi	200795|Chloroflexi	K	intracellular signal transduction	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,TPR_12
k59_697936_1	1187851.A33M_3622	7.41e-88	266.0	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,2TSDS@28211|Alphaproteobacteria,3FE54@34008|Rhodovulum	28211|Alphaproteobacteria	U	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_419212_1	1172188.KB911821_gene1462	2.27e-09	58.9	COG4425@1|root,COG4425@2|Bacteria,2GKB5@201174|Actinobacteria,4FEF7@85021|Intrasporangiaceae	201174|Actinobacteria	S	Alpha/beta-hydrolase family N-terminus	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_9,Abhydrolase_9_N
k59_1491471_1	996637.SGM_2860	1.39e-51	177.0	COG0372@1|root,COG0372@2|Bacteria,2GJ7E@201174|Actinobacteria	201174|Actinobacteria	C	Belongs to the citrate synthase family	gltA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
k59_599682_2	1396418.BATQ01000185_gene2101	2.73e-25	98.6	2EHU8@1|root,33BJW@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1434658_1	1120983.KB894572_gene3146	1.88e-107	333.0	29ISC@1|root,2Z7VE@2|Bacteria,1MWUK@1224|Proteobacteria,2TTFU@28211|Alphaproteobacteria,1JPZS@119043|Rhodobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
k59_1655371_1	861299.J421_6020	2.21e-71	239.0	COG3250@1|root,COG3250@2|Bacteria	2|Bacteria	G	beta-galactosidase activity	csxA	GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0005575,GO:0005576,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0016052,GO:0016787,GO:0016798,GO:0043170,GO:0044238,GO:0071704,GO:1901575	3.2.1.165	ko:K15855	ko00520,ko01100,map00520,map01100	-	R01966	RC00049	ko00000,ko00001,ko01000	-	-	-	CBM_35,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
k59_1714307_1	671143.DAMO_2633	3.54e-72	232.0	COG1253@1|root,COG1253@2|Bacteria,2NP04@2323|unclassified Bacteria	2|Bacteria	S	Transporter associated domain	ytfL	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03699,ko:K06189	-	-	-	-	ko00000,ko02000,ko02042	9.A.40.1.2	-	-	CBS,CorC_HlyC,DUF21,TerC
k59_209421_1	948106.AWZT01000054_gene1544	9.77e-79	255.0	COG3387@1|root,COG3387@2|Bacteria,1MV08@1224|Proteobacteria,2VHBN@28216|Betaproteobacteria,1K0YU@119060|Burkholderiaceae	28216|Betaproteobacteria	G	PFAM glycoside hydrolase 15-related	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_15
k59_1212152_1	866536.Belba_1571	6.64e-57	190.0	COG3867@1|root,COG3867@2|Bacteria,4NI3G@976|Bacteroidetes,47MXH@768503|Cytophagia	976|Bacteroidetes	G	Arabinogalactan	-	-	3.2.1.89	ko:K01224	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_hydro_53
k59_155604_1	477184.KYC_21561	5.51e-114	341.0	COG0277@1|root,COG0277@2|Bacteria,1MUPW@1224|Proteobacteria,2VI8J@28216|Betaproteobacteria	28216|Betaproteobacteria	C	PFAM FAD linked oxidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
k59_654263_1	1100720.ALKN01000028_gene2451	4e-117	353.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2VJ55@28216|Betaproteobacteria,4AAYC@80864|Comamonadaceae	28216|Betaproteobacteria	H	TIGRFAM acetolactate synthase, large subunit, biosynthetic type	xsc	-	2.2.1.6,2.3.3.15,4.1.1.8	ko:K01577,ko:K01652,ko:K03852	ko00290,ko00430,ko00630,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00430,map00630,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R01908,R03050,R04672,R04673,R05651,R08648	RC00027,RC00106,RC00620,RC01192,RC02744,RC02893,RC02903,RC02909	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_1212161_1	1207063.P24_00880	9.16e-81	251.0	COG1363@1|root,COG1363@2|Bacteria,1MXEU@1224|Proteobacteria,2TSPX@28211|Alphaproteobacteria,2JQ84@204441|Rhodospirillales	204441|Rhodospirillales	G	M42 glutamyl aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
k59_1158146_1	187272.Mlg_1095	1.32e-34	128.0	COG4544@1|root,COG4544@2|Bacteria,1MZQU@1224|Proteobacteria,1S9RP@1236|Gammaproteobacteria,1WZQP@135613|Chromatiales	135613|Chromatiales	D	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division	-	-	-	ko:K14160	-	-	-	-	ko00000,ko03400	-	-	-	SulA
k59_1158146_2	207954.MED92_03977	1.01e-16	77.0	COG1974@1|root,COG1974@2|Bacteria,1MW80@1224|Proteobacteria,1RMXF@1236|Gammaproteobacteria,1XJ8P@135619|Oceanospirillales	135619|Oceanospirillales	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
k59_1158150_1	1382315.JPOI01000001_gene335	4.53e-63	206.0	COG2224@1|root,COG2224@2|Bacteria,1TP1U@1239|Firmicutes,4HBBD@91061|Bacilli,1WFNX@129337|Geobacillus	91061|Bacilli	C	isocitrate	aceA	-	4.1.3.1	ko:K01637	ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200	M00012	R00479	RC00311,RC00313	ko00000,ko00001,ko00002,ko01000	-	-	-	ICL
k59_100479_1	1266914.ATUK01000010_gene1266	1.23e-59	207.0	COG3280@1|root,COG3280@2|Bacteria	2|Bacteria	G	synthase	treY	GO:0000272,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005984,GO:0005991,GO:0005992,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009251,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016052,GO:0016853,GO:0016866,GO:0030978,GO:0030980,GO:0034637,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0047470,GO:0071704,GO:1901575,GO:1901576	2.4.1.25,5.4.99.15	ko:K00705,ko:K06044	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01824,R05196,R09995	RC00049	ko00000,ko00001,ko00002,ko01000	-	GH13,GH77	-	Alpha-amylase,Glyco_hydro_77
k59_492012_1	1484460.JSWG01000019_gene2075	2.76e-34	131.0	COG1538@1|root,COG1538@2|Bacteria,4NEEN@976|Bacteroidetes,1HZAB@117743|Flavobacteriia	976|Bacteroidetes	MU	Outer membrane efflux protein	tolC	-	-	ko:K12340	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	1.B.17,2.A.6.2	-	-	OEP
k59_492012_2	313596.RB2501_00536	1.61e-10	59.7	COG1136@1|root,COG1136@2|Bacteria,4NEC5@976|Bacteroidetes,1HYIR@117743|Flavobacteriia	976|Bacteroidetes	V	COG1136 ABC-type antimicrobial peptide transport system ATPase component	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
k59_1047727_1	637389.Acaty_c1155	4.91e-16	82.0	COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,1RP4T@1236|Gammaproteobacteria,2NCCE@225057|Acidithiobacillales	225057|Acidithiobacillales	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	-	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_1047727_2	1002672.SAR11G3_00407	3.27e-12	68.2	COG0118@1|root,COG0118@2|Bacteria,1MU4X@1224|Proteobacteria,2TTT4@28211|Alphaproteobacteria,4BQA9@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
k59_1212207_1	338963.Pcar_1870	2.15e-18	89.7	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,42MFK@68525|delta/epsilon subdivisions,2WKBU@28221|Deltaproteobacteria,43S4Y@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035,ko:K13893	ko02010,ko02024,map02010,map02024	M00239,M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.21,3.A.1.5.24	-	-	SBP_bac_5
k59_265659_1	861299.J421_4459	4.06e-97	308.0	COG3250@1|root,COG3250@2|Bacteria	2|Bacteria	G	beta-galactosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
k59_1714369_1	1032480.MLP_31880	2.05e-38	140.0	COG0560@1|root,COG3830@1|root,COG0560@2|Bacteria,COG3830@2|Bacteria,2GJDH@201174|Actinobacteria,4DN8I@85009|Propionibacteriales	201174|Actinobacteria	E	phosphoserine phosphatase	serB	GO:0003674,GO:0003824,GO:0004647,GO:0004721,GO:0004722,GO:0005488,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016597,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0031406,GO:0036094,GO:0036211,GO:0040007,GO:0042578,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:0140096,GO:1901564	3.1.3.3	ko:K01079	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R00582	RC00017	ko00000,ko00001,ko00002,ko01000,ko01009	-	-	iNJ661.Rv3042c	ACT_6,HAD
k59_991561_1	65393.PCC7424_3832	1.6e-119	365.0	COG3119@1|root,COG3119@2|Bacteria,1G22U@1117|Cyanobacteria,3KKRW@43988|Cyanothece	1117|Cyanobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_1437010_1	1210884.HG799475_gene15269	8.18e-86	269.0	COG0033@1|root,COG0033@2|Bacteria,2IYG0@203682|Planctomycetes	203682|Planctomycetes	G	Phosphoglucomutase/phosphomannomutase, C-terminal domain	-	-	5.4.2.2	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00549	R00959,R01057,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_1049639_1	1382230.ASAP_1231	3.82e-28	111.0	COG1309@1|root,COG1309@2|Bacteria,1MUUY@1224|Proteobacteria	1224|Proteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
k59_1214442_2	1207055.C100_22720	2.73e-24	102.0	COG3384@1|root,COG3384@2|Bacteria,1R6R4@1224|Proteobacteria,2U82Q@28211|Alphaproteobacteria,2K4FE@204457|Sphingomonadales	204457|Sphingomonadales	S	Catalytic LigB subunit of aromatic ring-opening dioxygenase	-	-	-	ko:K15061,ko:K15065	ko00627,ko01120,map00627,map01120	-	R09272,R09276	RC01306,RC01369	ko00000,ko00001,ko01000	-	-	-	LigB
k59_1273255_1	926569.ANT_26250	5.81e-47	155.0	COG1963@1|root,COG1963@2|Bacteria,2G6XC@200795|Chloroflexi	200795|Chloroflexi	S	Divergent PAP2 family	-	-	-	ko:K09775	-	-	-	-	ko00000	-	-	-	DUF212
k59_1273255_2	1449350.OCH239_19420	1.26e-11	61.6	COG1722@1|root,COG1722@2|Bacteria,1PTYQ@1224|Proteobacteria,2UFD6@28211|Alphaproteobacteria,4KN07@93682|Roseivivax	28211|Alphaproteobacteria	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
k59_1214458_1	391165.GbCGDNIH1_0848	1.34e-103	310.0	COG0568@1|root,COG0568@2|Bacteria,1MVWR@1224|Proteobacteria,2TR9Q@28211|Alphaproteobacteria,2JPF6@204441|Rhodospirillales	204441|Rhodospirillales	K	RNA polymerase sigma	rpoH	-	-	ko:K03089	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r4
k59_1769560_1	1121456.ATVA01000019_gene1268	3.55e-48	172.0	COG2202@1|root,COG4251@1|root,COG2202@2|Bacteria,COG4251@2|Bacteria,1NWNJ@1224|Proteobacteria	1224|Proteobacteria	T	PAS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,GAF_2,HATPase_c,HisKA,MHYT,PAS,PAS_3,PAS_4,PAS_9,dCache_1
k59_211559_1	452863.Achl_2947	7.26e-18	86.7	COG0438@1|root,COG0438@2|Bacteria,2GVEW@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4
k59_656358_1	1380394.JADL01000001_gene3101	3.08e-13	72.8	COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,2TUEW@28211|Alphaproteobacteria,2JV5D@204441|Rhodospirillales	204441|Rhodospirillales	EGP	Sugar (and other) transporter	-	-	-	ko:K08151	-	M00668	-	-	ko00000,ko00002,ko01504,ko02000	2.A.1.2.38,2.A.1.2.39,2.A.1.2.4,2.A.1.2.41,2.A.1.2.68,2.A.1.2.75	-	-	MFS_1
k59_1546582_2	1121920.AUAU01000036_gene1117	2.3e-05	47.0	COG1703@1|root,COG1703@2|Bacteria,3Y40X@57723|Acidobacteria	57723|Acidobacteria	E	ArgK protein	-	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK,Glyoxalase_4
k59_993764_1	797114.C475_14928	3.86e-56	187.0	COG0604@1|root,arCOG01458@2157|Archaea,2XU0Q@28890|Euryarchaeota,23SPC@183963|Halobacteria	183963|Halobacteria	C	COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases	qor1	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_381008_1	1051632.TPY_0652	1.01e-19	87.8	COG3384@1|root,COG3384@2|Bacteria	2|Bacteria	S	3-carboxyethylcatechol 2,3-dioxygenase activity	hpaD	-	1.13.11.15,1.13.11.74,1.13.11.76	ko:K00455,ko:K15058,ko:K15059	ko00350,ko00627,ko01120,ko01220,map00350,map00627,map01120,map01220	M00533	R03303,R05405	RC00387,RC00643	ko00000,ko00001,ko00002,ko01000	-	-	-	LigB
k59_1382527_1	1082933.MEA186_04546	3.91e-65	208.0	COG4424@1|root,COG4424@2|Bacteria,1QXYU@1224|Proteobacteria,2UH28@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
k59_1769594_1	1121930.AQXG01000015_gene1832	5.31e-74	240.0	COG1217@1|root,COG1217@2|Bacteria,4NDVM@976|Bacteroidetes,1IQXV@117747|Sphingobacteriia	976|Bacteroidetes	T	GTP-binding protein TypA	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
k59_825469_1	1454004.AW11_01423	9.79e-32	124.0	COG2423@1|root,COG2423@2|Bacteria,1N3EI@1224|Proteobacteria,2WFNY@28216|Betaproteobacteria,1KR5H@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	E	Ornithine cyclodeaminase/mu-crystallin family	-	-	4.3.1.12	ko:K01750	ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230	-	R00671	RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
k59_825471_1	1101192.KB910516_gene2087	9.51e-31	121.0	COG0252@1|root,COG0252@2|Bacteria,1MWIR@1224|Proteobacteria,2U1B3@28211|Alphaproteobacteria,1JR2V@119045|Methylobacteriaceae	28211|Alphaproteobacteria	EJ	PFAM Asparaginase glutaminase	-	-	3.5.1.1	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	-	R00485	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Asparaginase
k59_102959_1	357808.RoseRS_1612	1.09e-44	164.0	COG0277@1|root,COG0277@2|Bacteria,2G5TM@200795|Chloroflexi,3766Z@32061|Chloroflexia	32061|Chloroflexia	C	PFAM FAD linked oxidase domain protein	-	-	1.1.2.4	ko:K00102	ko00620,map00620	-	R00197	RC00044	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_881018_1	395494.Galf_0971	2.74e-54	182.0	COG3547@1|root,COG3547@2|Bacteria,1P502@1224|Proteobacteria,2W9QQ@28216|Betaproteobacteria,44WNJ@713636|Nitrosomonadales	28216|Betaproteobacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1327972_1	404589.Anae109_3628	6.71e-36	128.0	COG2041@1|root,COG2041@2|Bacteria,1MUW0@1224|Proteobacteria	1224|Proteobacteria	C	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
k59_1214534_1	190650.CC_3670	6.01e-19	89.4	COG0697@1|root,COG0697@2|Bacteria	2|Bacteria	EG	spore germination	ydzE	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_656410_1	983544.Lacal_0179	1.31e-31	125.0	COG0508@1|root,COG0508@2|Bacteria,4NED0@976|Bacteroidetes,1HWW8@117743|Flavobacteriia	976|Bacteroidetes	C	dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex	bfmBB	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_1327981_1	357808.RoseRS_0631	3.06e-88	264.0	COG3335@1|root,COG3335@2|Bacteria,2G8GI@200795|Chloroflexi	200795|Chloroflexi	L	SPTR Q2LSA8 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
k59_211622_2	1459636.NTE_00104	1.04e-31	120.0	COG0183@1|root,arCOG01278@2157|Archaea,41SCI@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Thiolase, N-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_494918_1	1207076.ALAT01000160_gene3260	1.07e-70	238.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMDS@1236|Gammaproteobacteria,1Z1AB@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	J	Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs	rne	-	3.1.26.12	ko:K08300	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
k59_1604140_1	639283.Snov_1927	5.91e-13	72.4	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2TQMR@28211|Alphaproteobacteria,3EZ1R@335928|Xanthobacteraceae	28211|Alphaproteobacteria	V	ABC transporter transmembrane region	msbA	-	-	ko:K06147,ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_547474_1	338963.Pcar_0639	9.44e-73	237.0	COG0471@1|root,COG0471@2|Bacteria,1MUSA@1224|Proteobacteria,42MAP@68525|delta/epsilon subdivisions,2WIYI@28221|Deltaproteobacteria,43SPT@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Sodium:sulfate symporter transmembrane region	-	-	-	ko:K14445	-	-	-	-	ko00000,ko02000	2.A.47.1	-	-	Na_sulph_symp
k59_547474_2	338963.Pcar_0640	2.16e-29	107.0	29AVF@1|root,2ZXUP@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_436131_1	861299.J421_3672	1.85e-44	159.0	2EYW5@1|root,33S36@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1382621_2	323098.Nwi_2460	2.77e-18	77.8	COG3360@1|root,COG3360@2|Bacteria,1PE74@1224|Proteobacteria,2UCH8@28211|Alphaproteobacteria,3K04J@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
k59_158221_1	113395.AXAI01000004_gene4176	9.02e-37	135.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
k59_547491_1	1123355.JHYO01000007_gene402	5.32e-52	176.0	COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,2TSD1@28211|Alphaproteobacteria,36X4A@31993|Methylocystaceae	28211|Alphaproteobacteria	I	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal	dxr	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
k59_716767_1	1279017.AQYJ01000024_gene943	1.72e-55	193.0	COG4264@1|root,COG4264@2|Bacteria,1QUJJ@1224|Proteobacteria,1RQQ0@1236|Gammaproteobacteria,4672K@72275|Alteromonadaceae	1236|Gammaproteobacteria	Q	IucA / IucC family	iucA	-	6.3.2.38	ko:K03894	ko00310,ko01120,map00310,map01120	-	R10090	RC00064,RC00090	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_8,FhuF,IucA_IucC
k59_103028_1	926569.ANT_09980	2.34e-129	404.0	COG0085@1|root,COG0085@2|Bacteria,2G5VH@200795|Chloroflexi	200795|Chloroflexi	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_1104207_1	373903.Hore_00600	1.66e-84	266.0	COG2759@1|root,COG2759@2|Bacteria,1TP6N@1239|Firmicutes,247P5@186801|Clostridia,3WAEU@53433|Halanaerobiales	186801|Clostridia	F	PFAM Formate--tetrahydrofolate ligase	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
k59_46263_1	1382356.JQMP01000004_gene215	1.06e-45	157.0	COG0434@1|root,COG0434@2|Bacteria,2G6UF@200795|Chloroflexi,27Y89@189775|Thermomicrobia	189775|Thermomicrobia	S	BtpA family	-	-	-	ko:K06971	-	-	-	-	ko00000	-	-	-	BtpA
k59_881112_2	479434.Sthe_1045	1.01e-28	105.0	COG0186@1|root,COG0186@2|Bacteria,2G722@200795|Chloroflexi,27YK1@189775|Thermomicrobia	189775|Thermomicrobia	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
k59_881112_3	1487956.DR71_1448	0.00034	41.2	COG0093@1|root,COG0093@2|Bacteria,2IHNX@201174|Actinobacteria,22N79@1653|Corynebacteriaceae	201174|Actinobacteria	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0008150,GO:0015934,GO:0016020,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071944,GO:0097159,GO:1901363,GO:1990904	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
k59_939958_1	1411123.JQNH01000001_gene119	4.11e-38	139.0	COG2801@1|root,COG2801@2|Bacteria,1MWNX@1224|Proteobacteria,2TZ7M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	LZ_Tnp_IS481,rve,rve_3
k59_1273504_1	1382306.JNIM01000001_gene3678	2.11e-27	113.0	COG0501@1|root,COG0501@2|Bacteria,2G6KE@200795|Chloroflexi	200795|Chloroflexi	O	PFAM peptidase M48 Ste24p	-	-	3.4.24.84	ko:K06013	ko00900,ko01130,map00900,map01130	-	R09845	RC00141	ko00000,ko00001,ko01000,ko01002,ko04147	-	-	-	Peptidase_M48,Peptidase_M48_N
k59_1214620_1	926569.ANT_02410	5.38e-39	142.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	pelF	-	-	ko:K21011,ko:K21012	ko02025,map02025	-	-	-	ko00000,ko00001,ko01003	-	GT4	-	DUF3492,Glyco_trans_1_4,Glycos_transf_1
k59_825601_1	649831.L083_6291	3.01e-67	209.0	COG2041@1|root,COG2041@2|Bacteria,2GMG2@201174|Actinobacteria,4DBY2@85008|Micromonosporales	201174|Actinobacteria	S	Oxidoreductase molybdopterin binding domain	nia2	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
k59_1049799_1	1111728.ATYS01000028_gene2654	1.31e-26	111.0	COG3181@1|root,COG3181@2|Bacteria,1P88K@1224|Proteobacteria,1SYHY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_1769768_2	551789.ATVJ01000002_gene2984	3.63e-05	46.6	COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,2TRIQ@28211|Alphaproteobacteria,43WZ7@69657|Hyphomonadaceae	28211|Alphaproteobacteria	E	Belongs to the DegT DnrJ EryC1 family	degT	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
k59_1161359_1	309801.trd_0711	2.76e-85	271.0	COG0365@1|root,COG0365@2|Bacteria,2G5KE@200795|Chloroflexi,27XEK@189775|Thermomicrobia	189775|Thermomicrobia	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_1716590_1	580332.Slit_0533	2.1e-54	191.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,2VJ72@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Adenylyl cyclase class-3 4 guanylyl cyclase	cyaA	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
k59_952415_32	1238184.CM001792_gene2536	6.22e-22	88.6	2DYSU@1|root,34AZ0@2|Bacteria,1VZ25@1239|Firmicutes,4HZDF@91061|Bacilli,23N49@182709|Oceanobacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_952415_33	1380387.JADM01000008_gene955	4.58e-42	144.0	2CJKM@1|root,314EI@2|Bacteria,1RGVN@1224|Proteobacteria,1T082@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_952415_34	714943.Mucpa_6145	1.62e-64	223.0	COG0305@1|root,COG0305@2|Bacteria,4NF8P@976|Bacteroidetes,1IPIQ@117747|Sphingobacteriia	976|Bacteroidetes	L	Participates in initiation and elongation during chromosome replication	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
k59_952415_35	598467.BrE312_2431	3.31e-36	138.0	28N2X@1|root,2ZB8P@2|Bacteria,1R4KJ@1224|Proteobacteria,1T3E3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	sty2063 SWALL Q8Z5Z8 (EMBL AL627272) (262 aa) fasta scores E() 1.5e-07, 24.43 id in 266 aa, and to Escherichia coli O157 H7	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_952415_41	1335760.ASTG01000033_gene19	1.96e-41	149.0	COG4712@1|root,COG4712@2|Bacteria,1N9U1@1224|Proteobacteria,2UVCK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Rad52/22 family double-strand break repair protein	-	-	-	-	-	-	-	-	-	-	-	-	Rad52_Rad22
k59_952415_44	911008.GLAD_00742	1.71e-23	95.9	2EBAP@1|root,335BB@2|Bacteria,1NCXU@1224|Proteobacteria,1SDBM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_952415_45	1238190.AMQY01000021_gene1590	5.9e-31	115.0	2EIQ2@1|root,33CFI@2|Bacteria,1NHAI@1224|Proteobacteria,1SSQC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_952415_48	406818.XBJ1_1192	7.54e-10	59.7	2BV1E@1|root,32QE3@2|Bacteria,1PK54@1224|Proteobacteria,1SH7F@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF2591)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2591
k59_787469_1	1123236.KB899376_gene508	5.99e-71	224.0	COG2826@1|root,COG2826@2|Bacteria,1MWI0@1224|Proteobacteria,1RRSE@1236|Gammaproteobacteria,467FY@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_38,rve
k59_1398846_1	1121949.AQXT01000002_gene1027	1.6e-44	146.0	COG3436@1|root,COG3436@2|Bacteria,1RHDW@1224|Proteobacteria,2U7TH@28211|Alphaproteobacteria,4404C@69657|Hyphomonadaceae	28211|Alphaproteobacteria	L	IS66 Orf2 like protein	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	TnpB_IS66
k59_1398846_2	1121949.AQXT01000002_gene1025	2.25e-23	97.8	COG2963@1|root,COG2963@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	HTH_28,HTH_Tnp_1
k59_1620926_1	1117647.M5M_13590	5.08e-93	295.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,1RPDE@1236|Gammaproteobacteria,1J8XH@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	COG3119 Arylsulfatase A and related enzymes	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_231588_2	983545.Glaag_4196	1.24e-05	49.3	COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,1RNHC@1236|Gammaproteobacteria,465UQ@72275|Alteromonadaceae	1236|Gammaproteobacteria	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	cyoE	GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008495,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
k59_9218_1	716928.AJQT01000071_gene4110	8.2e-73	223.0	COG0394@1|root,COG0394@2|Bacteria,1MWYQ@1224|Proteobacteria,2TU1U@28211|Alphaproteobacteria,4BBYM@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Belongs to the low molecular weight phosphotyrosine protein phosphatase family	-	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	HTH_20,LMWPc
k59_1065223_1	379066.GAU_1326	2.22e-55	192.0	COG2217@1|root,COG2217@2|Bacteria,1ZUMP@142182|Gemmatimonadetes	142182|Gemmatimonadetes	P	E1-E2 ATPase	-	-	3.6.3.4	ko:K01533	-	-	R00086	RC00002	ko00000,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase
k59_342332_1	265072.Mfla_0353	7.89e-08	56.2	COG1801@1|root,COG1801@2|Bacteria,1MU7F@1224|Proteobacteria,2VIFI@28216|Betaproteobacteria,2KNAM@206350|Nitrosomonadales	206350|Nitrosomonadales	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
k59_342332_2	1358423.N180_21025	6.33e-20	89.7	COG2234@1|root,COG2234@2|Bacteria,4NFDJ@976|Bacteroidetes,1IQ2M@117747|Sphingobacteriia	976|Bacteroidetes	S	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
k59_231595_1	479434.Sthe_0936	8.77e-78	258.0	COG0458@1|root,COG0458@2|Bacteria,2G5NX@200795|Chloroflexi,27XRT@189775|Thermomicrobia	189775|Thermomicrobia	F	Carbamoyl-phosphate synthetase large chain, oligomerisation domain	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_342342_1	439235.Dalk_2858	2.68e-36	133.0	COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,42NR9@68525|delta/epsilon subdivisions,2WKX1@28221|Deltaproteobacteria,2MHZU@213118|Desulfobacterales	28221|Deltaproteobacteria	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
k59_398141_1	604331.AUHY01000074_gene1811	2.92e-131	385.0	COG3328@1|root,COG3328@2|Bacteria,1WN6I@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	L	MULE transposase domain	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_620364_2	1205680.CAKO01000002_gene2922	4.46e-19	89.4	COG0477@1|root,COG2814@2|Bacteria,1QUAS@1224|Proteobacteria,2UAZV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_454033_1	688245.CtCNB1_4416	7.32e-27	108.0	COG0346@1|root,COG0346@2|Bacteria,1R8NP@1224|Proteobacteria,2VN1R@28216|Betaproteobacteria,4AD10@80864|Comamonadaceae	28216|Betaproteobacteria	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase_3
k59_620369_1	595537.Varpa_4769	1.4e-22	93.6	COG0607@1|root,COG0607@2|Bacteria,1MZ83@1224|Proteobacteria,2VU3D@28216|Betaproteobacteria,4AEDM@80864|Comamonadaceae	28216|Betaproteobacteria	P	PFAM Rhodanese domain protein	glpE	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
k59_620371_1	378806.STAUR_4671	2.04e-41	152.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,42N8Y@68525|delta/epsilon subdivisions,2WIR7@28221|Deltaproteobacteria,2YTYX@29|Myxococcales	28221|Deltaproteobacteria	C	dihydrolipoamide dehydrogenase	lpdA	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_1009948_1	926569.ANT_08300	1.53e-85	254.0	COG0377@1|root,COG0377@2|Bacteria,2G6GB@200795|Chloroflexi	200795|Chloroflexi	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB1	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
k59_1676841_2	634500.EbC_28990	4.25e-40	144.0	COG1215@1|root,COG1215@2|Bacteria,1QU2F@1224|Proteobacteria,1RYY5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_9259_1	479431.Namu_2239	1.38e-16	84.7	COG1404@1|root,COG1404@2|Bacteria,2GK3D@201174|Actinobacteria,4EVNZ@85013|Frankiales	201174|Actinobacteria	O	PA domain	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_S8,fn3_5
k59_509359_2	1056820.KB900699_gene1277	5.14e-27	107.0	COG1664@1|root,COG1664@2|Bacteria,1ND4H@1224|Proteobacteria,1SF92@1236|Gammaproteobacteria,2PP92@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
k59_898981_1	1122919.KB905590_gene3968	3.92e-31	124.0	COG3250@1|root,COG3250@2|Bacteria,1TQAM@1239|Firmicutes,4HB7S@91061|Bacilli,26SR5@186822|Paenibacillaceae	91061|Bacilli	G	Belongs to the glycosyl hydrolase 2 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
k59_9264_1	1040989.AWZU01000004_gene6961	1.16e-12	72.8	COG0596@1|root,COG0596@2|Bacteria,1QTTN@1224|Proteobacteria,2TRYE@28211|Alphaproteobacteria,3JRD7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Serine aminopeptidase, S33	MA20_09375	-	3.1.1.24	ko:K01055	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00568	R02991	RC00825	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1
k59_231646_1	888832.HMPREF9420_1924	2.8e-29	120.0	COG1472@1|root,COG1472@2|Bacteria,4NE90@976|Bacteroidetes,2FMCU@200643|Bacteroidia	976|Bacteroidetes	G	Glycosyl hydrolase family 3	bglX2	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
k59_64609_1	1304878.AUGD01000010_gene4711	9.09e-70	223.0	COG0498@1|root,COG0498@2|Bacteria,1R7X1@1224|Proteobacteria,2TUR3@28211|Alphaproteobacteria,3JU0E@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Pyridoxal-phosphate dependent enzyme	MA20_41710	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_787558_1	379066.GAU_0739	4.79e-58	202.0	COG0612@1|root,COG0612@2|Bacteria,1ZT1M@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Insulinase (Peptidase family M16)	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_1565712_1	795359.TOPB45_0120	1.78e-06	52.4	COG4105@1|root,COG4105@2|Bacteria,2GGXR@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Tetratricopeptide repeat	-	-	-	ko:K05807	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	YfiO
k59_1732421_1	498848.TaqDRAFT_5324	2.29e-10	66.2	COG0715@1|root,COG0715@2|Bacteria,1WJPE@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
k59_1398929_1	62928.azo3230	9.47e-75	231.0	COG1058@1|root,COG1058@2|Bacteria,1MVG6@1224|Proteobacteria,2VHTD@28216|Betaproteobacteria,2KUEQ@206389|Rhodocyclales	206389|Rhodocyclales	S	Molybdopterin binding	-	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
k59_1454916_2	622637.KE124774_gene2483	4.83e-58	188.0	COG0400@1|root,COG0400@2|Bacteria,1RA02@1224|Proteobacteria,2TTWP@28211|Alphaproteobacteria,36XYZ@31993|Methylocystaceae	28211|Alphaproteobacteria	S	Phospholipase/Carboxylesterase	-	-	-	ko:K06999	-	-	-	-	ko00000	-	-	-	Abhydrolase_2
k59_509407_1	1242864.D187_003825	3.09e-11	69.3	COG0667@1|root,COG0667@2|Bacteria,1QJYC@1224|Proteobacteria,42QD6@68525|delta/epsilon subdivisions,2WJ6W@28221|Deltaproteobacteria,2Z31C@29|Myxococcales	28221|Deltaproteobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_1121418_1	1298593.TOL_3013	1.57e-67	220.0	COG3516@1|root,COG3517@1|root,COG3516@2|Bacteria,COG3517@2|Bacteria,1NAN0@1224|Proteobacteria,1S07D@1236|Gammaproteobacteria,1XNIK@135619|Oceanospirillales	135619|Oceanospirillales	S	Type VI secretion system, VipA, VC_A0107 or Hcp2	-	-	-	ko:K11900	ko02025,map02025	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	T6SS_VipA,VipB
k59_1121422_1	1120983.KB894573_gene318	2.4e-99	299.0	COG1176@1|root,COG1176@2|Bacteria,1MVGM@1224|Proteobacteria,2TSFD@28211|Alphaproteobacteria,1JNKD@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	Binding-protein-dependent transport system inner membrane component	potH	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015695,GO:0015696,GO:0015846,GO:0015847,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351	-	ko:K11075	ko02010,map02010	M00300	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.2	-	-	BPD_transp_1
k59_398235_2	118168.MC7420_7660	2.3e-05	49.7	COG0642@1|root,COG5002@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1G09B@1117|Cyanobacteria,1H82F@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE4,GAF,GAF_3,HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg
k59_1010023_1	749414.SBI_04631	1.1e-39	150.0	COG0488@1|root,COG2319@1|root,COG0488@2|Bacteria,COG2319@2|Bacteria,2GJN3@201174|Actinobacteria	201174|Actinobacteria	F	WD-40 repeat	-	-	-	-	-	-	-	-	-	-	-	-	ANAPC4_WD40,HTH_3,HTH_31,WD40
k59_1010032_2	111780.Sta7437_3729	2.76e-12	63.9	COG0691@1|root,COG0691@2|Bacteria,1G542@1117|Cyanobacteria,3VJN0@52604|Pleurocapsales	1117|Cyanobacteria	O	the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
k59_1398959_1	267608.RSc1761	4.94e-85	263.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2VIF8@28216|Betaproteobacteria,1K03I@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_1732474_1	926559.JoomaDRAFT_3251	3.88e-26	110.0	COG2270@1|root,COG2270@2|Bacteria,4NEKI@976|Bacteroidetes,1HXEF@117743|Flavobacteriia	976|Bacteroidetes	S	Major facilitator superfamily	-	-	-	ko:K06902	ko04138,map04138	-	-	-	ko00000,ko00001,ko02000,ko04131	2.A.1.24,9.A.15.1	-	-	ATG22
k59_342471_2	926690.KE386573_gene1154	1.84e-14	72.4	COG0114@1|root,arCOG01749@2157|Archaea,2XT2J@28890|Euryarchaeota,23T2J@183963|Halobacteria	183963|Halobacteria	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	-	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
k59_1343301_1	95619.PM1_0205905	2.6e-43	160.0	COG4223@1|root,COG4223@2|Bacteria,1N10X@1224|Proteobacteria,1RYCQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Thymidine phosphorylase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1631
k59_9356_1	309807.SRU_0275	3.14e-59	202.0	COG0021@1|root,COG0021@2|Bacteria,4P14U@976|Bacteroidetes,1FIXF@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	G	Transketolase, thiamine diphosphate binding domain	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
k59_175829_1	313589.JNB_12788	1.92e-50	168.0	COG0122@1|root,COG0122@2|Bacteria,2IPPK@201174|Actinobacteria,4FJWM@85021|Intrasporangiaceae	201174|Actinobacteria	L	endonuclease III	-	-	3.2.2.21	ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
k59_1343303_1	391037.Sare_1138	4.57e-16	81.6	COG0265@1|root,COG0265@2|Bacteria,2II1D@201174|Actinobacteria,4D8QJ@85008|Micromonosporales	201174|Actinobacteria	O	Peptidase s1 and s6 chymotrypsin hap	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin_2
k59_64686_1	698761.RTCIAT899_CH14480	1.58e-66	213.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,4BA4C@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Transposase and inactivated derivatives	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_9362_1	1120948.KB903217_gene1284	1.41e-40	145.0	COG0309@1|root,COG0309@2|Bacteria,2GJ7N@201174|Actinobacteria,4DXSM@85010|Pseudonocardiales	201174|Actinobacteria	O	hydrogenase expression formation protein HypE	hypE	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
k59_9362_2	469383.Cwoe_2547	1.81e-11	60.8	COG0375@1|root,COG0375@2|Bacteria,2IMJK@201174|Actinobacteria	201174|Actinobacteria	S	Hydrogenase nickel incorporation protein hypA	hypA	-	-	ko:K04651	-	-	-	-	ko00000,ko03110	-	-	-	HypA
k59_1176634_1	1002672.SAR11G3_01328	4.46e-06	47.4	COG0719@1|root,COG0719@2|Bacteria,1MVKY@1224|Proteobacteria,2TRU6@28211|Alphaproteobacteria,4BPG7@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	O	FeS assembly protein SufB	sufB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009536,GO:0009842,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
k59_1176634_2	743836.AYNA01000081_gene3100	1.76e-54	178.0	COG0396@1|root,COG0396@2|Bacteria,1MUGK@1224|Proteobacteria,2TS8T@28211|Alphaproteobacteria,36X9K@31993|Methylocystaceae	28211|Alphaproteobacteria	O	ABC transporter	sufC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051186,GO:0071840	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
k59_1732492_1	246194.CHY_0587	1.21e-32	120.0	COG3945@1|root,COG3945@2|Bacteria,1V3TS@1239|Firmicutes	1239|Firmicutes	S	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
k59_676543_1	446465.Bfae_05830	8.94e-26	104.0	COG2197@1|root,COG2197@2|Bacteria,2GN3A@201174|Actinobacteria,4FBP3@85020|Dermabacteraceae	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_564833_1	1038859.AXAU01000003_gene6195	1.71e-65	218.0	COG3203@1|root,COG3203@2|Bacteria,1R49B@1224|Proteobacteria	1224|Proteobacteria	M	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF3573
k59_899109_1	1273125.Rrhod_2757	3.2e-57	198.0	COG0243@1|root,COG0243@2|Bacteria,2GJCK@201174|Actinobacteria,4FVTT@85025|Nocardiaceae	201174|Actinobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	bisC	-	1.8.5.3,1.97.1.9	ko:K07306,ko:K07309,ko:K07310,ko:K08351	ko00450,ko00780,ko00920,ko01100,map00450,map00780,map00920,map01100	-	R07229,R09501,R10127	RC02420,RC02555,RC03056	ko00000,ko00001,ko01000,ko02000	5.A.3.3,5.A.3.4	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal
k59_1233309_1	926569.ANT_07100	2.61e-100	305.0	COG1129@1|root,COG1129@2|Bacteria,2G7YP@200795|Chloroflexi	200795|Chloroflexi	P	ATPases associated with a variety of cellular activities	-	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
k59_342498_1	1121930.AQXG01000008_gene201	0.000702	49.3	COG0823@1|root,COG1228@1|root,COG0823@2|Bacteria,COG1228@2|Bacteria,4PM8I@976|Bacteroidetes,1IQP3@117747|Sphingobacteriia	976|Bacteroidetes	QU	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,PD40
k59_1176656_1	215803.DB30_2603	6.46e-09	60.5	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2YUB5@29|Myxococcales	28221|Deltaproteobacteria	T	response regulator	-	-	-	ko:K10943	ko02020,ko05111,map02020,map05111	M00515	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_231771_1	861299.J421_2272	9.78e-28	115.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_64718_1	1329516.JPST01000063_gene1787	3.71e-06	50.1	COG0052@1|root,COG0052@2|Bacteria,1TPNA@1239|Firmicutes,4H9N5@91061|Bacilli,27AV1@186824|Thermoactinomycetaceae	91061|Bacilli	J	Ribosomal protein S2	rpsB	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
k59_1249804_1	1120746.CCNL01000007_gene442	2.24e-26	111.0	COG1195@1|root,COG1195@2|Bacteria,2NPEJ@2323|unclassified Bacteria	2|Bacteria	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	GO:0000731,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0018130,GO:0019438,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901576	-	ko:K03629,ko:K07459	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	SMC_N
k59_473074_1	82654.Pse7367_1577	6.64e-38	146.0	COG0531@1|root,COG0531@2|Bacteria,1G248@1117|Cyanobacteria,1H8SD@1150|Oscillatoriales	1117|Cyanobacteria	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease,SLC12
k59_972704_1	1265507.KB899636_gene1815	3.06e-33	131.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,1RMU2@1236|Gammaproteobacteria,1Y3ZQ@135624|Aeromonadales	135624|Aeromonadales	C	fumarate reductase flavoprotein subunit	frdA	-	1.3.5.4	ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_1416598_1	1304865.JAGF01000001_gene3842	3.41e-19	87.8	COG0541@1|root,COG0541@2|Bacteria,2GK4R@201174|Actinobacteria,4F0U2@85016|Cellulomonadaceae	201174|Actinobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
k59_1416598_2	760192.Halhy_3879	5.5e-23	94.4	COG0228@1|root,COG0228@2|Bacteria,4NNY8@976|Bacteroidetes,1IRXR@117747|Sphingobacteriia	976|Bacteroidetes	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
k59_918155_1	1089547.KB913013_gene3119	2.03e-76	249.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,4NETS@976|Bacteroidetes,47KF8@768503|Cytophagia	976|Bacteroidetes	EU	Dipeptidyl peptidase IV (DPP IV) N-terminal region	dpp	-	3.4.14.5	ko:K01278	ko04974,map04974	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	DPPIV_N,Peptidase_S9
k59_248899_1	1120948.KB903247_gene4612	3.85e-78	248.0	COG4799@1|root,COG4799@2|Bacteria,2GIRU@201174|Actinobacteria,4DZ29@85010|Pseudonocardiales	201174|Actinobacteria	I	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)	-	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
k59_1416606_1	1521187.JPIM01000048_gene77	1.73e-64	211.0	COG3677@1|root,COG3677@2|Bacteria,2G6SJ@200795|Chloroflexi,3772U@32061|Chloroflexia	32061|Chloroflexia	L	PFAM Transposase IS66 family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_137535_1	44251.PDUR_07870	5.71e-40	150.0	COG0488@1|root,COG0488@2|Bacteria,1TPAX@1239|Firmicutes,4H9ZK@91061|Bacilli,26QSZ@186822|Paenibacillaceae	91061|Bacilli	S	ABC transporter, ATP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
k59_694765_1	1245471.PCA10_10790	7.58e-70	226.0	COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,1RN88@1236|Gammaproteobacteria,1YDS2@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	M	Belongs to the MurCDEF family	murC	GO:0000166,GO:0000270,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008763,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034645,GO:0035639,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0046872,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	iECP_1309.ECP_0093	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_1527849_1	639030.JHVA01000001_gene2359	9.87e-22	97.4	COG0577@1|root,COG0577@2|Bacteria,3Y76W@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_1527849_2	861299.J421_6359	4.78e-55	197.0	COG0577@1|root,COG0577@2|Bacteria	861299.J421_6359|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1637978_1	391626.OAN307_c03800	5.73e-152	437.0	COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,2TRVA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG2826 Transposase and inactivated derivatives, IS30 family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_38,rve
k59_1029078_1	886293.Sinac_2843	1.81e-51	183.0	COG1680@1|root,COG2173@1|root,COG1680@2|Bacteria,COG2173@2|Bacteria,2IWSU@203682|Planctomycetes	203682|Planctomycetes	MV	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,Peptidase_M15
k59_1251747_1	331869.BAL199_01584	6.23e-18	81.6	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TRH6@28211|Alphaproteobacteria,4BQ46@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	P	COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_1251747_2	1223521.BBJX01000004_gene2279	5.82e-33	127.0	COG0747@1|root,COG0747@2|Bacteria,1MWBH@1224|Proteobacteria,2VHY1@28216|Betaproteobacteria,4AC8X@80864|Comamonadaceae	28216|Betaproteobacteria	E	PFAM extracellular solute-binding protein, family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_416097_1	526225.Gobs_1216	4.07e-80	248.0	COG2801@1|root,COG2801@2|Bacteria,2GKDY@201174|Actinobacteria,4ESNN@85013|Frankiales	201174|Actinobacteria	L	PFAM Integrase catalytic region	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_2,rve_3
k59_416097_2	743718.Isova_2773	3.71e-10	57.0	COG2963@1|root,COG2963@2|Bacteria,2IHPH@201174|Actinobacteria,4F5JN@85017|Promicromonosporaceae	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
k59_137557_1	1499968.TCA2_4906	4.44e-11	65.1	COG1595@1|root,COG1595@2|Bacteria,1VANG@1239|Firmicutes,4HK62@91061|Bacilli,26THQ@186822|Paenibacillaceae	91061|Bacilli	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_360046_1	502025.Hoch_2000	5.34e-103	321.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,42MER@68525|delta/epsilon subdivisions,2WIYV@28221|Deltaproteobacteria,2YW7P@29|Myxococcales	28221|Deltaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2_2
k59_637523_1	1163617.SCD_n01945	8.66e-08	57.0	COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,1MU9M@1224|Proteobacteria,2VJUR@28216|Betaproteobacteria	28216|Betaproteobacteria	S	AAA domain	-	-	-	ko:K07028	-	-	-	-	ko00000	-	-	-	AAA_33,APH
k59_637523_2	926690.KE386573_gene263	3.95e-06	50.8	COG0784@1|root,arCOG02331@1|root,arCOG02331@2157|Archaea,arCOG02333@2157|Archaea,2XST7@28890|Euryarchaeota,23S1Y@183963|Halobacteria	183963|Halobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
k59_1472897_1	926569.ANT_11770	2.42e-97	301.0	COG0498@1|root,COG0784@1|root,COG0498@2|Bacteria,COG0784@2|Bacteria,2G5RK@200795|Chloroflexi	200795|Chloroflexi	E	PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_918207_1	1232410.KI421425_gene1565	4.54e-37	143.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42NEG@68525|delta/epsilon subdivisions,2WKHA@28221|Deltaproteobacteria,43TY6@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	actB	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_1139555_1	983545.Glaag_3796	9.66e-62	203.0	COG1914@1|root,COG1914@2|Bacteria,1MW6X@1224|Proteobacteria,1RNA2@1236|Gammaproteobacteria,464TF@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	COG1914 Mn2 and Fe2 transporters of the NRAMP family	mntH	-	-	-	-	-	-	-	-	-	-	-	Nramp
k59_972774_1	351607.Acel_1759	1.32e-63	219.0	COG0653@1|root,COG0653@2|Bacteria,2GIRT@201174|Actinobacteria,4ERM3@85013|Frankiales	201174|Actinobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_1583664_1	1379270.AUXF01000006_gene303	1.06e-53	189.0	COG4775@1|root,COG4775@2|Bacteria,1ZT6B@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Surface antigen	-	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
k59_360062_1	426355.Mrad2831_0491	5.07e-33	129.0	COG0150@1|root,COG0150@2|Bacteria,1MURG@1224|Proteobacteria,2TR6G@28211|Alphaproteobacteria,1JRKH@119045|Methylobacteriaceae	28211|Alphaproteobacteria	F	PFAM AIR synthase related protein	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
k59_1251770_1	1484460.JSWG01000006_gene2951	5.45e-87	280.0	COG1506@1|root,COG1506@2|Bacteria,4NDVD@976|Bacteroidetes,1HYH5@117743|Flavobacteriia	976|Bacteroidetes	E	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
k59_305327_1	251229.Chro_1874	1.04e-53	178.0	COG0106@1|root,COG0106@2|Bacteria,1G1S9@1117|Cyanobacteria,3VIJV@52604|Pleurocapsales	1117|Cyanobacteria	E	1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase	hisA	GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
k59_248960_1	391038.Bphy_4766	2.36e-58	195.0	COG0438@1|root,COG0438@2|Bacteria,1MWSZ@1224|Proteobacteria,2VN89@28216|Betaproteobacteria,1K6BI@119060|Burkholderiaceae	28216|Betaproteobacteria	M	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
k59_1139572_1	379066.GAU_0484	3.8e-113	350.0	COG0188@1|root,COG0188@2|Bacteria,1ZTFF@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_972789_2	502025.Hoch_5756	2.7e-49	172.0	COG2133@1|root,COG2133@2|Bacteria,1PG5V@1224|Proteobacteria,4389W@68525|delta/epsilon subdivisions,2XA3Y@28221|Deltaproteobacteria,2YWB0@29|Myxococcales	28221|Deltaproteobacteria	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
k59_1695549_1	398578.Daci_5631	2.36e-18	91.7	COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,2VITF@28216|Betaproteobacteria,4ABU5@80864|Comamonadaceae	28216|Betaproteobacteria	EQ	PFAM Hydantoinase B oxoprolinase	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
k59_248970_2	997884.HMPREF1068_00651	7.61e-43	154.0	COG4799@1|root,COG4799@2|Bacteria,4NEMJ@976|Bacteroidetes,2FQWG@200643|Bacteroidia,4AP51@815|Bacteroidaceae	976|Bacteroidetes	I	COG COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)	-	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_1527904_1	264732.Moth_2412	1.67e-38	140.0	COG2876@1|root,COG2876@2|Bacteria,1TP61@1239|Firmicutes,24812@186801|Clostridia,42EJY@68295|Thermoanaerobacterales	186801|Clostridia	E	DAHP synthetase I family	-	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
k59_749693_2	667632.KB890209_gene5441	7.5e-19	85.9	COG1079@1|root,COG1079@2|Bacteria,1MVDQ@1224|Proteobacteria,2VHBU@28216|Betaproteobacteria,1K2QE@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
k59_473182_1	317619.ANKN01000161_gene301	6.48e-22	97.1	COG0475@1|root,COG0475@2|Bacteria,1G03Z@1117|Cyanobacteria,1MM0K@1212|Prochloraceae	1117|Cyanobacteria	P	Na H antiporter	kefB	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
k59_473182_2	1265507.KB899636_gene1112	1.02e-50	176.0	COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,1MV3Z@1224|Proteobacteria,1RMAJ@1236|Gammaproteobacteria,1Y43R@135624|Aeromonadales	135624|Aeromonadales	H	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	hldE	-	2.7.1.167,2.7.7.70	ko:K03272	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_like,PfkB
k59_305355_1	765420.OSCT_2720	2.7e-104	333.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,2G5M1@200795|Chloroflexi,376VN@32061|Chloroflexia	32061|Chloroflexia	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	-	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_248982_2	452637.Oter_3675	1.44e-31	117.0	COG1150@1|root,COG1150@2|Bacteria	2|Bacteria	C	4Fe-4S dicluster domain	hdrC	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389,ko:K03390,ko:K16887,ko:K18930	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_3424	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17,Fer4_7,Fer4_8,Fer4_9
k59_527376_1	1128421.JAGA01000003_gene3421	2.7e-39	140.0	COG0325@1|root,COG0325@2|Bacteria,2NPEW@2323|unclassified Bacteria	2|Bacteria	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	yggS	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
k59_527376_2	931276.Cspa_c26380	0.000101	43.9	COG3599@1|root,COG3599@2|Bacteria,1V27M@1239|Firmicutes,24MM3@186801|Clostridia,36FZ8@31979|Clostridiaceae	186801|Clostridia	D	PFAM DivIVA family protein	divIVA	-	-	ko:K04074	-	-	-	-	ko00000,ko03036	-	-	-	DivIVA
k59_82651_1	251229.Chro_3613	1.44e-84	258.0	COG0580@1|root,COG0580@2|Bacteria,1G3MJ@1117|Cyanobacteria	1117|Cyanobacteria	U	Belongs to the MIP aquaporin (TC 1.A.8) family	-	-	-	ko:K06188	-	-	-	-	ko00000,ko02000	1.A.8	-	-	MIP
k59_1306124_1	68170.KL590504_gene10095	3.02e-16	80.1	COG1657@1|root,COG1657@2|Bacteria,2GM7H@201174|Actinobacteria,4E0JR@85010|Pseudonocardiales	201174|Actinobacteria	I	Squalene-hopene cyclase C-terminal domain	-	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009267,GO:0009605,GO:0009607,GO:0009975,GO:0009987,GO:0009991,GO:0010350,GO:0016101,GO:0016102,GO:0016114,GO:0016853,GO:0016872,GO:0019637,GO:0031667,GO:0031668,GO:0031669,GO:0033385,GO:0033554,GO:0035439,GO:0035440,GO:0042594,GO:0043167,GO:0043169,GO:0043207,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044403,GO:0044419,GO:0046872,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0071496,GO:0071704,GO:0075136,GO:1901576	5.5.1.16	ko:K17811	-	-	-	-	ko00000,ko01000	-	-	-	Prenyltrans,SQHop_cyclase_C
k59_1527938_1	1123367.C666_14905	3e-91	282.0	COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,2VI8D@28216|Betaproteobacteria,2KVNI@206389|Rhodocyclales	206389|Rhodocyclales	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
k59_473221_1	1449355.JQNR01000005_gene5475	2.72e-63	206.0	COG1793@1|root,COG1793@2|Bacteria,2I2EA@201174|Actinobacteria	201174|Actinobacteria	L	dna ligase	ligC	-	-	-	-	-	-	-	-	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M
k59_582170_2	935840.JAEQ01000003_gene24	8.01e-61	204.0	COG1053@1|root,COG1053@2|Bacteria	2|Bacteria	C	succinate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2,FMN_bind
k59_193528_1	1278073.MYSTI_02797	1.92e-11	68.9	COG0577@1|root,COG0577@2|Bacteria,1NREW@1224|Proteobacteria	1224|Proteobacteria	V	COG0577 ABC-type antimicrobial peptide transport system permease component	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_805418_1	861299.J421_2157	1.49e-12	70.5	COG3629@1|root,COG3899@1|root,COG3629@2|Bacteria,COG3899@2|Bacteria,1ZUXK@142182|Gemmatimonadetes	2|Bacteria	T	AAA ATPase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	AAA_16,BTAD,TPR_12,Trans_reg_C
k59_972851_1	1097668.BYI23_C009390	4.77e-32	127.0	COG0492@1|root,COG3437@1|root,COG0492@2|Bacteria,COG3437@2|Bacteria,1MVX2@1224|Proteobacteria,2VM3V@28216|Betaproteobacteria,1K4AE@119060|Burkholderiaceae	28216|Betaproteobacteria	C	FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Response_reg
k59_305405_1	909663.KI867150_gene1539	3.96e-61	206.0	COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,42ME5@68525|delta/epsilon subdivisions,2WKA2@28221|Deltaproteobacteria,2MQBJ@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
k59_82673_1	861299.J421_0897	3.05e-83	259.0	COG0031@1|root,COG0031@2|Bacteria,1ZTA6@142182|Gemmatimonadetes	142182|Gemmatimonadetes	EK	Domain in cystathionine beta-synthase and other proteins.	-	-	4.2.1.22	ko:K01697	ko00260,ko00270,ko01100,ko01130,ko01230,map00260,map00270,map01100,map01130,map01230	M00035,M00338	R00891,R01290,R04942	RC00056,RC00069,RC00256,RC00489,RC01246	ko00000,ko00001,ko00002,ko01000	-	-	-	CBS,PALP
k59_305409_1	1353528.DT23_12465	5.04e-56	187.0	COG2358@1|root,COG2358@2|Bacteria,1MXW1@1224|Proteobacteria,2TSK2@28211|Alphaproteobacteria,2XN33@285107|Thioclava	28211|Alphaproteobacteria	S	C4-dicarboxylate ABC transporter	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
k59_1139641_1	1410650.JHWL01000010_gene2717	7.03e-77	238.0	COG1209@1|root,COG1209@2|Bacteria,1V301@1239|Firmicutes,247XE@186801|Clostridia,4BXTP@830|Butyrivibrio	186801|Clostridia	M	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis	rfbA	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
k59_416212_1	927677.ALVU02000001_gene2962	4.39e-63	211.0	COG0531@1|root,COG0531@2|Bacteria,1G2GM@1117|Cyanobacteria	1117|Cyanobacteria	E	PFAM Amino acid permease	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
k59_1361542_1	1278309.KB907102_gene39	1.58e-54	183.0	COG1485@1|root,COG1485@2|Bacteria,1MUUW@1224|Proteobacteria,1RMTJ@1236|Gammaproteobacteria,1XHYN@135619|Oceanospirillales	135619|Oceanospirillales	D	Reduces the stability of FtsZ polymers in the presence of ATP	zapE	-	-	ko:K06916	-	-	-	-	ko00000,ko03036	-	-	-	AFG1_ATPase
k59_305418_1	926569.ANT_17250	4.1e-33	123.0	COG0492@1|root,COG0492@2|Bacteria,2G5Z5@200795|Chloroflexi	200795|Chloroflexi	C	FAD-dependent pyridine nucleotide-disulphide oxidoreductase	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_305418_2	391603.FBALC1_06988	3.36e-18	84.0	COG0766@1|root,COG0766@2|Bacteria,4NDV8@976|Bacteroidetes,1HWNU@117743|Flavobacteriia	976|Bacteroidetes	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
k59_637624_1	1110697.NCAST_34_03170	3.06e-17	87.4	COG2909@1|root,COG2909@2|Bacteria,2I999@201174|Actinobacteria,4G1JB@85025|Nocardiaceae	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
k59_1361556_1	998674.ATTE01000001_gene2517	1.15e-85	261.0	COG1702@1|root,COG1702@2|Bacteria,1MVDV@1224|Proteobacteria,1RP2Y@1236|Gammaproteobacteria,46094@72273|Thiotrichales	72273|Thiotrichales	T	PhoH-like protein	-	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
k59_82702_1	1499685.CCFJ01000043_gene2536	0.000105	50.4	COG1653@1|root,COG3227@1|root,COG3979@1|root,COG4257@1|root,COG5492@1|root,COG1653@2|Bacteria,COG3227@2|Bacteria,COG3979@2|Bacteria,COG4257@2|Bacteria,COG5492@2|Bacteria,1V1KV@1239|Firmicutes,4HUKW@91061|Bacilli,1ZJ5H@1386|Bacillus	91061|Bacilli	E	Domain of unknown function (DUF5011)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5011,FTP,PepSY,Peptidase_M4,Peptidase_M4_C
k59_1749721_3	926569.ANT_30000	9.34e-09	56.2	COG1193@1|root,COG1193@2|Bacteria,2G5R8@200795|Chloroflexi	200795|Chloroflexi	L	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_III,MutS_V,Smr
k59_1306176_1	227882.SAV_7375	3.14e-64	219.0	COG0068@1|root,COG0068@2|Bacteria,2GJYF@201174|Actinobacteria	201174|Actinobacteria	O	Belongs to the carbamoyltransferase HypF family	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
k59_918360_1	420324.KI912010_gene8957	4.46e-17	84.3	COG1028@1|root,COG1028@2|Bacteria,1MUFX@1224|Proteobacteria,2TRWN@28211|Alphaproteobacteria,1JU86@119045|Methylobacteriaceae	28211|Alphaproteobacteria	IQ	PFAM short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_137703_1	666685.R2APBS1_2038	7.22e-42	154.0	COG1538@1|root,COG1538@2|Bacteria,1RFMJ@1224|Proteobacteria,1S8HY@1236|Gammaproteobacteria,1X7RA@135614|Xanthomonadales	135614|Xanthomonadales	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_1695675_1	1005048.CFU_1915	3.74e-95	291.0	COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,2VID7@28216|Betaproteobacteria,472E5@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
k59_249087_1	768704.Desmer_1365	5.25e-49	163.0	COG0262@1|root,COG0262@2|Bacteria,1VAUA@1239|Firmicutes,24G7Y@186801|Clostridia,263EC@186807|Peptococcaceae	186801|Clostridia	H	Dihydrofolate reductase	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
k59_749801_1	177437.HRM2_38950	4.53e-42	155.0	COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,1MV6C@1224|Proteobacteria,42MF5@68525|delta/epsilon subdivisions,2WKC6@28221|Deltaproteobacteria,2MPY1@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Domain of unknown function (DUF4445)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
k59_1416805_1	83406.HDN1F_06540	8.53e-107	311.0	COG0723@1|root,COG0723@2|Bacteria,1RAA2@1224|Proteobacteria,1RP9H@1236|Gammaproteobacteria,1J50E@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	petA	-	1.10.2.2	ko:K00411	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske,UCR_Fe-S_N
k59_1416805_2	83406.HDN1F_06550	5.91e-31	118.0	COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,1RNCP@1236|Gammaproteobacteria,1J5A4@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	petB	-	-	ko:K00412	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko03029	-	-	-	Cytochrom_B_C,Cytochrom_C1,Cytochrome_B
k59_473323_1	671143.DAMO_2917	9.75e-80	263.0	COG0667@1|root,COG1331@1|root,COG0667@2|Bacteria,COG1331@2|Bacteria,2NP26@2323|unclassified Bacteria	2|Bacteria	O	Protein of unknown function, DUF255	yyaL	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,GlcNAc_2-epim,Thioredox_DsbH
k59_1749767_1	329726.AM1_5308	3.05e-89	295.0	COG0642@1|root,COG0784@1|root,COG2202@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,1G09B@1117|Cyanobacteria	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE4,GAF,GAF_3,HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg
k59_660513_1	221288.JH992901_gene5016	1.81e-168	496.0	COG3039@1|root,COG3039@2|Bacteria,1G3IA@1117|Cyanobacteria,1JJJQ@1189|Stigonemataceae	1117|Cyanobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_1550296_1	356851.JOAN01000029_gene4992	2.11e-24	103.0	COG1409@1|root,COG1409@2|Bacteria,2GIT1@201174|Actinobacteria,4DM0J@85008|Micromonosporales	201174|Actinobacteria	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
k59_271563_1	472759.Nhal_1247	2.12e-63	218.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,1RR36@1236|Gammaproteobacteria	1236|Gammaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	AAA_16,Guanylate_cyc,HEAT_2,PP2C_2,Pkinase
k59_271565_1	314285.KT71_12790	5.16e-75	251.0	COG4447@1|root,COG4447@2|Bacteria,1MVIT@1224|Proteobacteria,1RZK1@1236|Gammaproteobacteria,1J9EJ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Sortilin, neurotensin receptor 3,	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
k59_50491_1	1577887.JSYG01000008_gene224	2.45e-16	80.9	COG2271@1|root,COG2271@2|Bacteria,1QU9E@1224|Proteobacteria,1T2A0@1236|Gammaproteobacteria,2JDFT@204037|Dickeya	1236|Gammaproteobacteria	G	PFAM major facilitator superfamily MFS_1	-	-	-	ko:K08223	-	-	-	-	ko00000,ko02000	2.A.1.35	-	-	MFS_1
k59_332633_1	861299.J421_3780	1.2e-37	145.0	COG0178@1|root,COG0178@2|Bacteria,1ZT1W@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	-	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_1054333_1	1267535.KB906767_gene911	8.2e-20	95.9	COG0497@1|root,COG0497@2|Bacteria	2|Bacteria	L	DNA recombination	tcdA2	-	-	ko:K03497,ko:K13582	ko04112,map04112	-	-	-	ko00000,ko00001,ko03000,ko03036,ko04812	-	-	-	SLH,VRP1
k59_1333486_1	861299.J421_6230	1.62e-73	243.0	COG4953@1|root,COG4953@2|Bacteria	2|Bacteria	M	penicillin binding	pbpC	-	2.4.1.129	ko:K05367	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	BiPBP_C,Transgly,Transpeptidase
k59_886685_1	926569.ANT_16790	1.57e-69	223.0	COG0403@1|root,COG0403@2|Bacteria,2G5NI@200795|Chloroflexi	200795|Chloroflexi	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
k59_886685_2	926569.ANT_16800	4.75e-08	55.1	COG1003@1|root,COG1003@2|Bacteria,2G5MU@200795|Chloroflexi	200795|Chloroflexi	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00281,ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
k59_829816_1	316067.Geob_1470	2.92e-30	116.0	COG1497@1|root,COG1497@2|Bacteria,1QXN4@1224|Proteobacteria,43C48@68525|delta/epsilon subdivisions,2X7EN@28221|Deltaproteobacteria,43V1T@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	Winged helix-turn-helix DNA-binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
k59_1333499_1	1278073.MYSTI_02898	1.06e-24	107.0	COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,42M9I@68525|delta/epsilon subdivisions,2WK1H@28221|Deltaproteobacteria,2YUDZ@29|Myxococcales	28221|Deltaproteobacteria	NU	Type II and III secretion system protein	gspD	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Secretin,Secretin_N
k59_1499347_2	977880.RALTA_A2610	1.35e-36	130.0	COG3917@1|root,COG3917@2|Bacteria,1MWB9@1224|Proteobacteria,2VKX5@28216|Betaproteobacteria,1K749@119060|Burkholderiaceae	28216|Betaproteobacteria	Q	2-hydroxychromene-2-carboxylate isomerase	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
k59_829832_2	1047013.AQSP01000089_gene1175	1.06e-52	177.0	COG0626@1|root,COG0626@2|Bacteria,2NNNS@2323|unclassified Bacteria	2|Bacteria	E	Cys/Met metabolism PLP-dependent enzyme	metC	-	2.5.1.48,4.4.1.11,4.4.1.8	ko:K01739,ko:K01760,ko:K01761	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00654,R00782,R00999,R01286,R01288,R02408,R02508,R03217,R03260,R04770,R04941,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00196,RC00348,RC00382,RC00420,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
k59_1550333_1	404380.Gbem_1774	1.32e-61	199.0	COG0726@1|root,COG0726@2|Bacteria,1MWMZ@1224|Proteobacteria,42P7W@68525|delta/epsilon subdivisions,2WMHU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	TIGRFAM polysaccharide deactylase family protein, PEP-CTERM locus subfamily	-	-	-	-	-	-	-	-	-	-	-	-	DUF3473,Polysacc_deac_1
k59_829836_1	485913.Krac_9361	2.86e-79	244.0	COG2084@1|root,COG2084@2|Bacteria,2G8RG@200795|Chloroflexi	200795|Chloroflexi	C	PFAM 6-phosphogluconate dehydrogenase NAD-binding	-	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
k59_1108696_1	1380391.JIAS01000017_gene680	5.26e-40	147.0	COG0628@1|root,COG0628@2|Bacteria,1MW0B@1224|Proteobacteria,2TRD3@28211|Alphaproteobacteria,2JPVK@204441|Rhodospirillales	204441|Rhodospirillales	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
k59_1054384_1	351348.Maqu_0611	1.45e-110	341.0	COG2909@1|root,COG2909@2|Bacteria,1MVZZ@1224|Proteobacteria,1S1AA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	PFAM regulatory protein LuxR	-	-	-	ko:K21748	-	-	-	-	ko00000,ko03000	-	-	-	GerE
k59_829856_1	313603.FB2170_04510	1.94e-61	194.0	COG0251@1|root,COG0251@2|Bacteria,4NPF9@976|Bacteroidetes,1I1J9@117743|Flavobacteriia,2PHH9@252356|Maribacter	976|Bacteroidetes	J	YjgF/chorismate_mutase-like, putative endoribonuclease	-	-	-	-	-	-	-	-	-	-	-	-	YjgF_endoribonc
k59_772865_1	926550.CLDAP_32230	1.01e-94	305.0	COG0553@1|root,COG0553@2|Bacteria,2G7XH@200795|Chloroflexi	200795|Chloroflexi	KL	SNF2 family N-terminal domain	-	-	2.7.11.1	ko:K08282	-	-	-	-	ko00000,ko01000	-	-	-	Helicase_C,SNF2_N,SNF2_assoc
k59_1662241_1	700598.Niako_6589	1.95e-36	132.0	COG0517@1|root,COG0517@2|Bacteria,4NF8G@976|Bacteroidetes,1IRUD@117747|Sphingobacteriia	976|Bacteroidetes	S	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_1387902_1	1379698.RBG1_1C00001G1627	2.42e-09	58.5	COG0465@1|root,COG0465@2|Bacteria,2NNQ5@2323|unclassified Bacteria	2|Bacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	GO:0000166,GO:0003674,GO:0003824,GO:0004175,GO:0004176,GO:0004222,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009056,GO:0009057,GO:0010468,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019222,GO:0019538,GO:0030145,GO:0030163,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043273,GO:0044238,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_1387902_2	203119.Cthe_2581	6.92e-36	134.0	COG0294@1|root,COG0294@2|Bacteria,1TPKT@1239|Firmicutes,248BE@186801|Clostridia,3WHB5@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS03115	Pterin_bind
k59_1662244_1	926569.ANT_01210	5.85e-94	288.0	COG0402@1|root,COG0402@2|Bacteria,2G5X1@200795|Chloroflexi	200795|Chloroflexi	F	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_886762_1	1123279.ATUS01000003_gene527	1.05e-30	122.0	COG2831@1|root,COG2831@2|Bacteria,1QW38@1224|Proteobacteria,1T2R4@1236|Gammaproteobacteria,1J75U@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	U	Protein of unknown function (DUF3570)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3570
k59_1662248_1	574376.BAMA_05425	1.91e-12	68.2	COG2021@1|root,COG2021@2|Bacteria,1TQSV@1239|Firmicutes,4HBNC@91061|Bacilli,1ZEVF@1386|Bacillus	91061|Bacilli	E	Belongs to the AB hydrolase superfamily. MetX family	metX	-	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
k59_660625_1	1220534.B655_1659	5.97e-52	185.0	COG0474@1|root,arCOG01578@2157|Archaea,2XW9W@28890|Euryarchaeota	28890|Euryarchaeota	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k59_50582_1	760011.Spico_0509	6.67e-60	199.0	COG0541@1|root,COG0541@2|Bacteria,2J5MF@203691|Spirochaetes	203691|Spirochaetes	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
k59_1218217_1	1205680.CAKO01000002_gene2365	5.86e-46	167.0	COG4547@1|root,COG4547@2|Bacteria,1MX11@1224|Proteobacteria,2TS4N@28211|Alphaproteobacteria,2JQPT@204441|Rhodospirillales	204441|Rhodospirillales	H	COG4547 Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide 5, 6-dimethylbenzimidazole phosphoribosyltransferase)	cobT	-	6.6.1.2	ko:K09883	ko00860,ko01100,map00860,map01100	-	R05227	RC02000	ko00000,ko00001,ko01000	-	-	-	CobT,CobT_C
k59_1166081_1	1306990.BARG01000052_gene6125	3.24e-06	53.9	COG1402@1|root,COG1402@2|Bacteria,2HCRK@201174|Actinobacteria	201174|Actinobacteria	S	Creatininase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
k59_1608490_1	1210884.HG799471_gene14579	4.54e-12	66.2	COG0712@1|root,COG0712@2|Bacteria,2J09A@203682|Planctomycetes	203682|Planctomycetes	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
k59_1608490_2	1267535.KB906767_gene3120	8.25e-36	134.0	COG0056@1|root,COG0056@2|Bacteria,3Y2R6@57723|Acidobacteria,2JIEV@204432|Acidobacteriia	204432|Acidobacteriia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
k59_1774635_1	1038860.AXAP01000029_gene683	9.63e-91	281.0	COG0166@1|root,COG0166@2|Bacteria,1MUFP@1224|Proteobacteria,2TQKP@28211|Alphaproteobacteria,3JWSI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Phosphoglucose isomerase	pgi	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
k59_271664_1	671143.DAMO_0707	8.46e-84	263.0	COG1003@1|root,COG1003@2|Bacteria,2NNSG@2323|unclassified Bacteria	2|Bacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	Aminotran_5,GDC-P
k59_106824_1	1123226.KB899277_gene1433	2.21e-34	129.0	COG0276@1|root,COG0276@2|Bacteria,1TPKF@1239|Firmicutes,4HAYG@91061|Bacilli,26SGK@186822|Paenibacillaceae	91061|Bacilli	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	GO:0003674,GO:0003824,GO:0004325,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
k59_106824_2	1191523.MROS_1220	1.01e-22	94.4	COG1959@1|root,COG1959@2|Bacteria	2|Bacteria	K	2 iron, 2 sulfur cluster binding	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
k59_1166099_1	298386.PBPRA0960	3.33e-35	127.0	COG1595@1|root,COG1595@2|Bacteria,1R9ZN@1224|Proteobacteria,1S27W@1236|Gammaproteobacteria,1Y2D5@135623|Vibrionales	135623|Vibrionales	K	Belongs to the sigma-70 factor family. ECF subfamily	sigV	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_440730_1	1128421.JAGA01000003_gene2772	5.05e-50	178.0	COG1132@1|root,COG1132@2|Bacteria,2NNVD@2323|unclassified Bacteria	2|Bacteria	V	ABC transporter	msbA2	-	-	ko:K06147,ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_1662284_1	868131.MSWAN_2197	2.14e-12	64.7	COG0622@1|root,arCOG01141@2157|Archaea,2XX8V@28890|Euryarchaeota	28890|Euryarchaeota	S	Phosphoesterase	-	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	Metallophos_2
k59_1662284_2	1260251.SPISAL_03310	4.6e-17	79.7	COG2231@1|root,COG2231@2|Bacteria,1RDJ8@1224|Proteobacteria,1RUHP@1236|Gammaproteobacteria,1WXXG@135613|Chromatiales	135613|Chromatiales	L	PFAM HhH-GPD	-	-	-	ko:K07457	-	-	-	-	ko00000	-	-	-	HhH-GPD
k59_829938_1	1265756.AWZW01000008_gene1282	1.7e-98	305.0	COG1053@1|root,COG1053@2|Bacteria,1NZBR@1224|Proteobacteria,2TSN4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	succinate dehydrogenase fumarate reductase, flavoprotein subunit	MA20_14860	-	1.8.99.2	ko:K00394	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00596	R00860,R04927,R08553	RC00007,RC01239,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_944583_1	330214.NIDE0891	6.34e-124	361.0	COG0535@1|root,COG0535@2|Bacteria,3J0X6@40117|Nitrospirae	40117|Nitrospirae	S	Domain of unknown function (DUF3463)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3463,Radical_SAM
k59_1333629_2	1173028.ANKO01000112_gene4868	3.16e-07	52.4	2E7MG@1|root,3323C@2|Bacteria,1GCRI@1117|Cyanobacteria,1HFKH@1150|Oscillatoriales	1117|Cyanobacteria	S	Coenzyme PQQ synthesis protein D (PqqD)	-	-	-	-	-	-	-	-	-	-	-	-	PqqD
k59_1387979_1	1121405.dsmv_0941	9.25e-51	177.0	COG4974@1|root,COG4974@2|Bacteria,1QU6A@1224|Proteobacteria,42Q4U@68525|delta/epsilon subdivisions,2WJ08@28221|Deltaproteobacteria,2MI4K@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Belongs to the 'phage' integrase family. XerC subfamily	xerC	-	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_1550429_2	1173028.ANKO01000112_gene4868	6.28e-20	85.5	2E7MG@1|root,3323C@2|Bacteria,1GCRI@1117|Cyanobacteria,1HFKH@1150|Oscillatoriales	1117|Cyanobacteria	S	Coenzyme PQQ synthesis protein D (PqqD)	-	-	-	-	-	-	-	-	-	-	-	-	PqqD
k59_1387981_1	290315.Clim_2109	5.15e-35	124.0	COG3654@1|root,COG3654@2|Bacteria	2|Bacteria	-	-	doc	-	-	ko:K07341	-	-	-	-	ko00000,ko02048	-	-	-	Fic
k59_1387981_2	1541065.JRFE01000026_gene2283	1.48e-12	62.8	COG2336@1|root,COG2336@2|Bacteria,1G908@1117|Cyanobacteria,3VMZY@52604|Pleurocapsales	1117|Cyanobacteria	T	SpoVT / AbrB like domain	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin
k59_829960_1	526227.Mesil_0202	4.31e-68	220.0	COG0458@1|root,COG0458@2|Bacteria	2|Bacteria	F	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_4
k59_721491_1	1380393.JHVP01000005_gene3614	1.45e-70	226.0	COG3547@1|root,COG3547@2|Bacteria,2GS79@201174|Actinobacteria,4ERY8@85013|Frankiales	201174|Actinobacteria	L	PFAM transposase IS116 IS110 IS902 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_721493_1	1267533.KB906733_gene3096	1.51e-24	107.0	COG1215@1|root,COG1215@2|Bacteria,3Y31I@57723|Acidobacteria,2JIKW@204432|Acidobacteriia	204432|Acidobacteriia	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
k59_1441702_1	756272.Plabr_0708	6.65e-17	77.8	COG1595@1|root,COG1595@2|Bacteria,2IZAB@203682|Planctomycetes	203682|Planctomycetes	K	COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
k59_1441702_2	861299.J421_0628	1.83e-20	95.5	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,1ZUHA@142182|Gemmatimonadetes	861299.J421_0628|-	KLT	Tetratricopeptide repeat	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	-
k59_215282_1	1121957.ATVL01000011_gene3618	5.45e-58	202.0	COG0793@1|root,COG0793@2|Bacteria,4NEK8@976|Bacteroidetes,47MAF@768503|Cytophagia	976|Bacteroidetes	M	Peptidase family S41	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S41
k59_1441710_1	378806.STAUR_1028	8.13e-48	168.0	COG2301@1|root,COG2301@2|Bacteria,1R7U2@1224|Proteobacteria,437FH@68525|delta/epsilon subdivisions,2X2N4@28221|Deltaproteobacteria,2YTXN@29|Myxococcales	28221|Deltaproteobacteria	G	Belongs to the HpcH HpaI aldolase family	-	-	-	-	-	-	-	-	-	-	-	-	HpcH_HpaI
k59_215287_1	216594.MMAR_1607	4.42e-54	186.0	COG1012@1|root,COG1012@2|Bacteria,2GJ95@201174|Actinobacteria,2338K@1762|Mycobacteriaceae	201174|Actinobacteria	C	Belongs to the aldehyde dehydrogenase family	putA_2	-	1.2.99.10	ko:K22445	-	-	-	-	ko00000,ko01000	-	-	-	Aldedh
k59_1662337_1	1214101.BN159_0944	5.09e-09	58.2	COG4803@1|root,COG4803@2|Bacteria,2IIN1@201174|Actinobacteria	201174|Actinobacteria	S	membrane protein of uknown function UCP014873	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1662337_2	1869.MB27_35100	6.84e-05	44.7	2E35Q@1|root,32Y5M@2|Bacteria,2GS2Q@201174|Actinobacteria,4DG42@85008|Micromonosporales	201174|Actinobacteria	S	Short C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	SHOCT
k59_385700_1	543728.Vapar_3712	6.77e-12	68.2	COG2068@1|root,COG2068@2|Bacteria,1MW0X@1224|Proteobacteria,2VRAE@28216|Betaproteobacteria,4ADZR@80864|Comamonadaceae	28216|Betaproteobacteria	S	MobA-like NTP transferase domain	-	-	2.7.7.76	ko:K07141	ko00790,map00790	-	R11582	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
k59_215294_1	1469245.JFBG01000038_gene1838	1.25e-24	105.0	COG0534@1|root,COG0534@2|Bacteria,1MUAM@1224|Proteobacteria,1RP5M@1236|Gammaproteobacteria,1WY3K@135613|Chromatiales	135613|Chromatiales	V	MatE	-	-	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
k59_721527_1	926550.CLDAP_22390	4.97e-53	179.0	COG0162@1|root,COG0162@2|Bacteria,2G64J@200795|Chloroflexi	200795|Chloroflexi	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
k59_1499542_1	300852.55771852	1.17e-42	154.0	COG0601@1|root,COG0601@2|Bacteria,1WIP3@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_271741_1	234267.Acid_5856	1.13e-19	97.1	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria	57723|Acidobacteria	KLTU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
k59_50699_1	45285.XP_003645037.1	0.000142	50.4	KOG0271@1|root,KOG0271@2759|Eukaryota,38HMB@33154|Opisthokonta,3NV28@4751|Fungi,3QMRJ@4890|Ascomycota,3RSVW@4891|Saccharomycetes,3RYWC@4893|Saccharomycetaceae	4751|Fungi	S	to Saccharomyces cerevisiae RSA4 (YCR072C)	RSA4	GO:0000027,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005730,GO:0005737,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0031974,GO:0031981,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043933,GO:0044085,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0065003,GO:0070013,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K14855	-	-	-	-	ko00000,ko03009	-	-	-	NLE,WD40
k59_499760_2	991.IW20_13040	8.88e-37	142.0	COG1960@1|root,COG1960@2|Bacteria,4NF87@976|Bacteroidetes,1I0JI@117743|Flavobacteriia,2NT59@237|Flavobacterium	976|Bacteroidetes	I	acyl-CoA oxidase	-	-	1.3.3.6	ko:K00232	ko00071,ko00592,ko01040,ko01100,ko01110,ko01212,ko03320,ko04024,ko04146,map00071,map00592,map01040,map01100,map01110,map01212,map03320,map04024,map04146	M00087,M00113	R01175,R01279,R03777,R03857,R03990,R04751,R04754,R07888,R07892,R07896,R07934,R07950	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000	-	-	-	ACOX,Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_830045_1	1173026.Glo7428_1784	6.2e-116	355.0	COG3957@1|root,COG3957@2|Bacteria,1G0B2@1117|Cyanobacteria	1117|Cyanobacteria	G	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase	-	-	4.1.2.22,4.1.2.9	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120	-	R00761,R01621	RC00032,RC00226	ko00000,ko00001,ko01000	-	-	-	XFP,XFP_C,XFP_N
k59_997435_1	649831.L083_3531	6.66e-14	72.0	COG3227@1|root,COG3227@2|Bacteria,2GN0P@201174|Actinobacteria,4D9AK@85008|Micromonosporales	201174|Actinobacteria	E	Fungalysin metallopeptidase (M36)	-	-	-	-	-	-	-	-	-	-	-	-	FTP,Peptidase_M36
k59_833795_2	1009858.BUMPG002_CDS00170	9.57e-06	47.4	COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,1RNW3@1236|Gammaproteobacteria,37D0I@32199|Buchnera	1236|Gammaproteobacteria	F	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	GO:0000018,GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0008301,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030554,GO:0030983,GO:0031323,GO:0032136,GO:0032300,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043531,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1990391	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	iECW_1372.ECW_m2935,iWFL_1372.ECW_m2935	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
k59_1553473_1	1230476.C207_04320	1.03e-10	67.8	COG2159@1|root,COG2159@2|Bacteria,1N0C7@1224|Proteobacteria,2TRXY@28211|Alphaproteobacteria,3JQNV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
k59_776106_1	1459636.NTE_00994	5.7e-108	318.0	COG1454@1|root,arCOG00984@2157|Archaea,41SFC@651137|Thaumarchaeota	651137|Thaumarchaeota	C	PFAM Iron-containing alcohol dehydrogenase	-	-	-	ko:K18602	ko00720,ko01120,map00720,map01120	-	R09289	RC00087	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
k59_1612150_1	443254.Marpi_0069	6.27e-08	57.0	COG2203@1|root,COG2206@1|root,COG2203@2|Bacteria,COG2206@2|Bacteria,2GCKV@200918|Thermotogae	200918|Thermotogae	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HD
k59_512674_1	675635.Psed_0101	8.93e-18	87.4	COG2079@1|root,COG2079@2|Bacteria,2GKUR@201174|Actinobacteria,4E0R9@85010|Pseudonocardiales	201174|Actinobacteria	S	protein involved in propionate catabolism	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
k59_123200_1	1535422.ND16A_3571	8.5e-83	256.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,1RMAQ@1236|Gammaproteobacteria,2Q707@267889|Colwelliaceae	1236|Gammaproteobacteria	L	Transposase	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1680148_1	321332.CYB_1457	9.49e-13	72.0	COG0664@1|root,COG0664@2|Bacteria,1G02U@1117|Cyanobacteria,1H0HQ@1129|Synechococcus	1117|Cyanobacteria	K	Cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
k59_12585_1	1121937.AUHJ01000004_gene1013	1.84e-44	158.0	COG2801@1|root,COG2801@2|Bacteria,1MXKK@1224|Proteobacteria,1T7KM@1236|Gammaproteobacteria,46C37@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	PFAM Integrase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1513414_1	425104.Ssed_1747	5.77e-41	154.0	COG0366@1|root,COG1409@1|root,COG0366@2|Bacteria,COG1409@2|Bacteria,1PKTM@1224|Proteobacteria,1RWFT@1236|Gammaproteobacteria,2QDDA@267890|Shewanellaceae	1236|Gammaproteobacteria	G	Bacterial Ig-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,Metallophos,Pur_ac_phosph_N
k59_623640_1	720555.BATR1942_19985	1.89e-19	91.3	COG0520@1|root,COG0520@2|Bacteria,1TRDP@1239|Firmicutes,4HBP7@91061|Bacilli,1ZQ2U@1386|Bacillus	91061|Bacilli	E	Selenocysteine lyase	ycbU	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
k59_345643_1	309801.trd_0219	7.5e-22	96.3	COG0464@1|root,COG0464@2|Bacteria,2G642@200795|Chloroflexi,27XW8@189775|Thermomicrobia	189775|Thermomicrobia	O	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_345643_2	1382359.JIAL01000001_gene2218	7.12e-16	77.0	COG2812@1|root,COG2812@2|Bacteria,3Y3C4@57723|Acidobacteria,2JHPD@204432|Acidobacteriia	204432|Acidobacteriia	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
k59_290641_1	1410620.SHLA_91c000050	8.58e-10	65.5	COG3181@1|root,COG3181@2|Bacteria,1MWVK@1224|Proteobacteria,2TXW7@28211|Alphaproteobacteria,4B8R1@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_902527_1	1137281.D778_01497	1.44e-56	186.0	COG3064@1|root,COG3064@2|Bacteria,4NESI@976|Bacteroidetes,1HXS4@117743|Flavobacteriia	976|Bacteroidetes	M	membrane	-	-	-	-	-	-	-	-	-	-	-	-	PorP_SprF
k59_235043_1	1379270.AUXF01000003_gene3730	4.72e-43	152.0	COG0436@1|root,COG0436@2|Bacteria,1ZTCU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Aminotransferase class I and II	-	-	2.6.1.83	ko:K10206	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_623670_2	1489678.RDMS_12410	2.98e-36	129.0	29NZE@1|root,32WP7@2|Bacteria	2|Bacteria	S	Helix-turn-helix of DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_4
k59_512757_1	45351.EDO29435	0.000122	47.4	COG2267@1|root,KOG1455@2759|Eukaryota,38I1Q@33154|Opisthokonta,3BHGS@33208|Metazoa	33208|Metazoa	I	Monoglyceride lipase	MGLL	GO:0001558,GO:0001676,GO:0003008,GO:0003013,GO:0003018,GO:0003674,GO:0003824,GO:0004620,GO:0004622,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005783,GO:0005789,GO:0005811,GO:0005829,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006638,GO:0006639,GO:0006690,GO:0006950,GO:0006952,GO:0006954,GO:0007275,GO:0007399,GO:0008015,GO:0008150,GO:0008152,GO:0008277,GO:0008361,GO:0009056,GO:0009966,GO:0009987,GO:0010646,GO:0010648,GO:0010769,GO:0010975,GO:0012505,GO:0016020,GO:0016042,GO:0016043,GO:0016298,GO:0016787,GO:0016788,GO:0019369,GO:0019752,GO:0019898,GO:0022008,GO:0022603,GO:0022604,GO:0023051,GO:0023057,GO:0030154,GO:0030424,GO:0030516,GO:0031344,GO:0031347,GO:0031644,GO:0031974,GO:0031981,GO:0031984,GO:0032101,GO:0032501,GO:0032502,GO:0032535,GO:0032787,GO:0033267,GO:0033559,GO:0035150,GO:0035296,GO:0036155,GO:0040008,GO:0042175,GO:0042802,GO:0042803,GO:0042995,GO:0043005,GO:0043196,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043436,GO:0044057,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044304,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044432,GO:0044444,GO:0044446,GO:0044463,GO:0044464,GO:0045202,GO:0045595,GO:0045664,GO:0046461,GO:0046464,GO:0046486,GO:0046503,GO:0046983,GO:0047372,GO:0048167,GO:0048519,GO:0048523,GO:0048583,GO:0048638,GO:0048699,GO:0048731,GO:0048856,GO:0048869,GO:0050727,GO:0050767,GO:0050770,GO:0050789,GO:0050793,GO:0050794,GO:0050804,GO:0050805,GO:0050880,GO:0050896,GO:0051128,GO:0051239,GO:0051930,GO:0051931,GO:0051960,GO:0052689,GO:0060284,GO:0060292,GO:0061387,GO:0065007,GO:0065008,GO:0070013,GO:0071704,GO:0071840,GO:0071944,GO:0080134,GO:0090066,GO:0097458,GO:0097746,GO:0097756,GO:0098827,GO:0099177,GO:0120025,GO:0120035,GO:0120038,GO:1901568,GO:1901575,GO:2000026,GO:2000124	3.1.1.23	ko:K01054	ko00561,ko01100,ko04714,ko04723,ko04923,map00561,map01100,map04714,map04723,map04923	M00098	R01351	RC00020,RC00041	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	Hydrolase_4
k59_1735718_1	765910.MARPU_08105	3.36e-118	356.0	COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,1RMJN@1236|Gammaproteobacteria,1WVXY@135613|Chromatiales	135613|Chromatiales	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
k59_1513466_1	926569.ANT_03750	1.96e-58	193.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	ssuA	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
k59_902548_1	861299.J421_6317	6e-32	130.0	COG0577@1|root,COG0577@2|Bacteria	861299.J421_6317|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_290667_2	1185653.A1A1_06367	7.99e-06	51.6	COG0614@1|root,COG0614@2|Bacteria,1UNE3@1239|Firmicutes,4H9ZX@91061|Bacilli,26D2S@186818|Planococcaceae	91061|Bacilli	P	COG0614 ABC-type Fe3 -hydroxamate transport system, periplasmic component	yvrC	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
k59_457593_1	1121381.JNIV01000159_gene212	3.53e-58	201.0	COG1132@1|root,COG1132@2|Bacteria,1WJ5B@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	V	ABC-type multidrug transport system ATPase and permease	-	-	-	ko:K18889	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106.13,3.A.1.106.5	-	-	ABC_membrane,ABC_tran
k59_457599_1	886293.Sinac_3610	1.82e-16	83.6	COG0673@1|root,COG0673@2|Bacteria,2J1Q1@203682|Planctomycetes	203682|Planctomycetes	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_902559_2	498761.HM1_0755	2.44e-64	209.0	COG0313@1|root,COG0313@2|Bacteria,1TP6U@1239|Firmicutes,24864@186801|Clostridia	186801|Clostridia	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
k59_1180018_1	743718.Isova_0649	1.88e-40	138.0	COG0222@1|root,COG0222@2|Bacteria,2IKNW@201174|Actinobacteria,4F4R2@85017|Promicromonosporaceae	201174|Actinobacteria	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
k59_957498_1	488538.SAR116_1462	5.46e-06	50.1	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2TSA6@28211|Alphaproteobacteria,4BPP9@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	amino acid	MA20_22615	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
k59_957498_2	331869.BAL199_12926	7.13e-44	149.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2TQVU@28211|Alphaproteobacteria,4BPW5@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	MA20_18645	-	-	ko:K01995,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C,BPD_transp_2
k59_401684_1	1380358.JADJ01000001_gene1138	1.09e-22	90.9	COG0599@1|root,COG0599@2|Bacteria,1N2ZQ@1224|Proteobacteria,1SBZC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	carboxymuconolactone decarboxylase	-	-	-	-	-	-	-	-	-	-	-	-	CMD
k59_401684_2	330214.NIDE2455	1.04e-53	184.0	COG0493@1|root,COG0493@2|Bacteria	2|Bacteria	C	'glutamate synthase	preT	-	1.18.1.2,1.19.1.1,1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K00528,ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R10159,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_20,Fer4_7,GXGXG,Pyr_redox_2,Pyr_redox_3
k59_1346609_1	1121468.AUBR01000012_gene2593	7.16e-66	218.0	COG0365@1|root,COG0365@2|Bacteria,1UMN9@1239|Firmicutes,25GME@186801|Clostridia	186801|Clostridia	I	AMP-binding enzyme C-terminal domain	-	-	6.2.1.32	ko:K08295	ko00627,ko01120,map00627,map01120	-	R00982	RC00004,RC00174	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C
k59_957510_1	1541065.JRFE01000058_gene5496	3.76e-47	160.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,Methyltransf_31,Ubie_methyltran
k59_845992_1	1121127.JAFA01000090_gene3621	4.58e-81	255.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,2VNU5@28216|Betaproteobacteria,1K1AA@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_179053_1	1299327.I546_1634	6.44e-25	95.9	COG3415@1|root,COG3415@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	ko:K07494	-	-	-	-	ko00000	-	-	-	DDE_3,HTH_23,HTH_28,HTH_29,HTH_32,LZ_Tnp_IS481
k59_179053_2	749414.SBI_08694	6.07e-29	115.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,2GJQI@201174|Actinobacteria	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
k59_345711_1	1223410.KN050846_gene2188	2.11e-48	167.0	COG2020@1|root,COG2020@2|Bacteria,4NJCI@976|Bacteroidetes,1I1CA@117743|Flavobacteriia	976|Bacteroidetes	O	Protein of unknown function (DUF1295)	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
k59_345711_2	266117.Rxyl_2320	3.87e-17	78.6	COG0071@1|root,COG0071@2|Bacteria,2IHVJ@201174|Actinobacteria,4CQKQ@84995|Rubrobacteria	84995|Rubrobacteria	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
k59_735652_1	1236973.JCM9157_4271	3.52e-10	63.9	COG0266@1|root,COG0266@2|Bacteria,1V0IH@1239|Firmicutes,4HCNZ@91061|Bacilli,1ZDTY@1386|Bacillus	91061|Bacilli	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	-	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
k59_735652_2	309807.SRU_1862	7.08e-14	74.3	COG0151@1|root,COG0151@2|Bacteria,4NEUN@976|Bacteroidetes,1FIUW@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	F	Phosphoribosylglycinamide synthetase, C domain	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
k59_1125035_1	1293054.HSACCH_01667	2.03e-69	232.0	COG0188@1|root,COG0188@2|Bacteria,1TP2Z@1239|Firmicutes,2482G@186801|Clostridia,3WA5S@53433|Halanaerobiales	186801|Clostridia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_235113_1	408672.NBCG_04718	7.43e-31	120.0	COG5640@1|root,COG5640@2|Bacteria,2IB3X@201174|Actinobacteria,4DPTD@85009|Propionibacteriales	201174|Actinobacteria	O	Trypsin-like serine protease	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin
k59_1735781_1	1408428.JNJP01000045_gene1976	1.89e-10	66.6	COG3852@1|root,COG3852@2|Bacteria,1NTTH@1224|Proteobacteria,42MC9@68525|delta/epsilon subdivisions,2WIYS@28221|Deltaproteobacteria,2M8UQ@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM ATP-binding region ATPase domain protein	-	-	2.7.13.3	ko:K07709	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_8,sCache_3_2
k59_1068794_1	926569.ANT_31250	1.65e-71	239.0	COG0474@1|root,COG0474@2|Bacteria,2G5ZS@200795|Chloroflexi	200795|Chloroflexi	P	TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k59_1735788_1	945713.IALB_0319	3.93e-11	64.7	COG1579@1|root,COG1579@2|Bacteria	2|Bacteria	-	-	CP_0228	-	3.5.4.16	ko:K07164,ko:K22391	ko00790,ko01100,map00790,map01100	M00126	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	zf-RING_7
k59_68028_1	485913.Krac_4421	7.43e-51	176.0	COG0477@1|root,COG2814@2|Bacteria,2G7AV@200795|Chloroflexi	200795|Chloroflexi	EGP	PFAM major facilitator superfamily MFS_1	-	-	-	ko:K08162	-	-	-	-	ko00000,ko02000	2.A.1.2.21	-	-	MFS_1,MFS_1_like,Sugar_tr
k59_235127_2	1168034.FH5T_18125	6.45e-49	169.0	COG1520@1|root,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
k59_457667_1	94624.Bpet0852	1.23e-75	238.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VMYW@28216|Betaproteobacteria,3T3PZ@506|Alcaligenaceae	28216|Betaproteobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_457677_2	97138.C820_02820	2.19e-24	102.0	COG0587@1|root,COG0587@2|Bacteria,1TPYG@1239|Firmicutes,247U0@186801|Clostridia,36DHP@31979|Clostridiaceae	186801|Clostridia	L	DNA polymerase	dnaE	-	2.7.7.7	ko:K02337,ko:K14162	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_290770_1	1236689.MMALV_00650	2.59e-54	184.0	COG0281@1|root,arCOG00853@2157|Archaea,2XSTN@28890|Euryarchaeota,3F2IM@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	Malic enzyme, NAD binding domain	maeB	-	1.1.1.38,1.1.1.40	ko:K00027,ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,ko02020,map00620,map00710,map01100,map01120,map01200,map02020	M00169,M00172	R00214,R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,PTA_PTB,malic
k59_457679_1	743836.AYNA01000044_gene1182	3.82e-55	186.0	COG1194@1|root,COG1194@2|Bacteria,1MUD4@1224|Proteobacteria,2TQVX@28211|Alphaproteobacteria,36XFF@31993|Methylocystaceae	28211|Alphaproteobacteria	L	FES	mutY	GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD,NUDIX_4
k59_457680_1	700598.Niako_2969	8.29e-97	298.0	COG0649@1|root,COG0852@1|root,COG0649@2|Bacteria,COG0852@2|Bacteria,4NF02@976|Bacteroidetes	976|Bacteroidetes	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K13378	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa,Complex1_49kDa
k59_1458410_1	1403819.BATR01000052_gene1588	4.6e-53	189.0	COG0222@1|root,COG0222@2|Bacteria	2|Bacteria	J	mitochondrial gene expression	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1735820_1	42256.RradSPS_0401	1.91e-30	119.0	COG0320@1|root,COG0320@2|Bacteria,2GKD4@201174|Actinobacteria,4CPF1@84995|Rubrobacteria	84995|Rubrobacteria	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
k59_680153_1	1121859.KB890750_gene566	1.73e-26	112.0	COG4198@1|root,COG4198@2|Bacteria,4NEQC@976|Bacteroidetes,47JPV@768503|Cytophagia	976|Bacteroidetes	S	Starch-binding associating with outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	SusD-like_2
k59_568210_1	1002339.HMPREF9373_0561	1.65e-19	90.1	COG2267@1|root,COG2267@2|Bacteria,1MX0N@1224|Proteobacteria,1RQGP@1236|Gammaproteobacteria,3NPPI@468|Moraxellaceae	1236|Gammaproteobacteria	I	TAP-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4,SnoaL_2
k59_179109_1	1342302.JASC01000007_gene2497	5.33e-65	213.0	COG4409@1|root,COG4409@2|Bacteria,1MVUD@1224|Proteobacteria,2TRQQ@28211|Alphaproteobacteria,3ZV8B@60136|Sulfitobacter	28211|Alphaproteobacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2
k59_1291106_1	1382356.JQMP01000004_gene486	4.52e-103	327.0	COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,2G86T@200795|Chloroflexi,27XQK@189775|Thermomicrobia	189775|Thermomicrobia	G	Alpha-amylase domain	-	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	APH,Alpha-amylase,Malt_amylase_C
k59_12753_1	367299.JOEE01000001_gene1780	2.68e-15	77.4	COG2041@1|root,COG2041@2|Bacteria,2GMG2@201174|Actinobacteria,4FE2W@85021|Intrasporangiaceae	201174|Actinobacteria	S	Oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
k59_12753_2	1382306.JNIM01000001_gene3000	1.93e-20	89.4	COG2141@1|root,COG2141@2|Bacteria,2G873@200795|Chloroflexi	200795|Chloroflexi	C	COGs COG2141 Coenzyme F420-dependent N5 N10-methylene tetrahydromethanopterin reductase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_846055_1	1408473.JHXO01000011_gene2955	1.76e-58	196.0	COG4623@1|root,COG4623@2|Bacteria,4NHFW@976|Bacteroidetes,2FN2R@200643|Bacteroidia	976|Bacteroidetes	M	Transglycosylase SLT domain protein	mltF	-	-	ko:K18691	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	SBP_bac_3,SLT
k59_1013695_1	552398.HMPREF0866_01573	3.15e-32	127.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1TPKJ@1239|Firmicutes,248NG@186801|Clostridia,3WGRT@541000|Ruminococcaceae	186801|Clostridia	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_68073_1	1122214.AQWH01000006_gene2380	3.27e-57	185.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2TSCA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	amino acid	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
k59_68073_2	1207063.P24_01035	3.64e-07	51.2	COG3964@1|root,COG3964@2|Bacteria,1MVC7@1224|Proteobacteria,2TSUD@28211|Alphaproteobacteria,2JRGD@204441|Rhodospirillales	204441|Rhodospirillales	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,Amidohydro_3
k59_1291123_1	390989.JOEG01000013_gene2512	1.41e-34	133.0	COG1090@1|root,COG4276@1|root,COG1090@2|Bacteria,COG4276@2|Bacteria,2GJS0@201174|Actinobacteria,4DA5A@85008|Micromonosporales	201174|Actinobacteria	S	Domain of unknown function (DUF1731)	-	-	-	ko:K07071	-	-	-	-	ko00000	-	-	-	DUF1731,Epimerase
k59_1458439_1	1089550.ATTH01000001_gene1977	5.15e-88	274.0	COG4799@1|root,COG4799@2|Bacteria,4NEMJ@976|Bacteroidetes,1FJPX@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	I	Carboxyl transferase domain	pccB	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_1735848_1	1125863.JAFN01000001_gene835	1.44e-19	92.4	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,42N2G@68525|delta/epsilon subdivisions,2WIXB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	PFAM AMP-dependent synthetase and ligase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding
k59_1015603_1	330214.NIDE3449	3.47e-97	293.0	COG5008@1|root,COG5008@2|Bacteria	2|Bacteria	NU	twitching motility protein	pilU	-	-	ko:K02670	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
k59_1515475_1	1500894.JQNN01000001_gene2324	1.15e-76	241.0	COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,2VI2K@28216|Betaproteobacteria,475QE@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Cys/Met metabolism PLP-dependent enzyme	mdeA_1	-	2.5.1.48,2.5.1.49	ko:K01739,ko:K01740	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00999,R01287,R01288,R02508,R03217,R03260,R04859,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00420,RC02821,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
k59_1070693_1	99598.Cal7507_5132	1.51e-56	187.0	COG0350@1|root,COG2207@1|root,COG0350@2|Bacteria,COG2207@2|Bacteria,1G3BJ@1117|Cyanobacteria,1HP35@1161|Nostocales	1117|Cyanobacteria	L	methylated-DNA- protein -cysteine S-methyltransferase	-	-	2.1.1.63	ko:K10778	-	-	-	-	ko00000,ko01000,ko03000,ko03400	-	-	-	Ada_Zn_binding,DNA_binding_1,HTH_18,Methyltransf_1N
k59_403646_1	1136177.KCA1_0516	3.88e-18	84.0	COG4956@1|root,COG4956@2|Bacteria,1TP0P@1239|Firmicutes,4H9NQ@91061|Bacilli,3F46T@33958|Lactobacillaceae	91061|Bacilli	S	domain protein	yacL	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	TRAM
k59_403646_2	1521187.JPIM01000130_gene681	5.2e-45	159.0	COG0215@1|root,COG0215@2|Bacteria,2G5Z0@200795|Chloroflexi,3756I@32061|Chloroflexia	32061|Chloroflexia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	-	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
k59_1070701_1	349521.HCH_06568	3.4e-06	54.3	COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,1RQK3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Cytosine deaminase and related metal-dependent	mtaD	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_1292939_1	316067.Geob_2763	1.41e-44	165.0	COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,42MN5@68525|delta/epsilon subdivisions,2WINN@28221|Deltaproteobacteria,43SYQ@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism	glnD	-	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,DUF294,GlnD_UR_UTase,GlnE,HD,NTP_transf_2
k59_459840_1	519989.ECTPHS_00730	1.07e-10	66.2	COG0664@1|root,COG0664@2|Bacteria,1R5P7@1224|Proteobacteria,1S6X3@1236|Gammaproteobacteria,1WWFD@135613|Chromatiales	135613|Chromatiales	K	PFAM Cyclic nucleotide-binding	-	-	-	ko:K21563	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
k59_570022_1	296591.Bpro_3892	1.72e-50	172.0	COG1721@1|root,COG1721@2|Bacteria,1Q7RR@1224|Proteobacteria,2VJHU@28216|Betaproteobacteria,4A9S6@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
k59_867804_1	1454004.AW11_00516	8.1e-100	304.0	COG0114@1|root,COG0114@2|Bacteria,1MUQI@1224|Proteobacteria,2VHA5@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	-	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
k59_145305_1	1380387.JADM01000002_gene2011	1.55e-113	348.0	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,1RMH7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	TRAP transporter, 4TM 12TM fusion protein	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_34595_2	517418.Ctha_1786	2.18e-17	79.0	COG0217@1|root,COG0217@2|Bacteria,1FDKV@1090|Chlorobi	1090|Chlorobi	K	transcriptional regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
k59_1315004_1	443143.GM18_1937	1.36e-53	184.0	COG0618@1|root,COG0618@2|Bacteria,1N0JS@1224|Proteobacteria,42P1S@68525|delta/epsilon subdivisions,2WJV0@28221|Deltaproteobacteria,43SCM@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	DHH family	-	-	-	-	-	-	-	-	-	-	-	-	DHH,DHHA1
k59_1369641_1	29495.EA26_02010	4.75e-103	323.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,1RQVT@1236|Gammaproteobacteria,1XZHW@135623|Vibrionales	135623|Vibrionales	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_645036_1	861299.J421_3048	1.73e-19	90.5	COG0060@1|root,COG0060@2|Bacteria,1ZSKS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
k59_1424757_1	875328.JDM601_3121	4.22e-41	149.0	COG2801@1|root,COG2801@2|Bacteria,2I8Z0@201174|Actinobacteria,237X9@1762|Mycobacteriaceae	201174|Actinobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_1424759_2	309801.trd_A0376	1.58e-52	173.0	COG1611@1|root,COG1611@2|Bacteria,2G6P1@200795|Chloroflexi,27Z6I@189775|Thermomicrobia	189775|Thermomicrobia	S	Possible lysine decarboxylase	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
k59_424048_1	1449336.JQLO01000001_gene1139	0.0003	48.1	COG0568@1|root,COG0568@2|Bacteria,1TPD6@1239|Firmicutes,4HB1H@91061|Bacilli,27F9X@186828|Carnobacteriaceae	91061|Bacilli	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_1037904_1	1110697.NCAST_34_02830	1.03e-39	149.0	COG2755@1|root,COG2755@2|Bacteria,2ICJT@201174|Actinobacteria,4G8NA@85025|Nocardiaceae	201174|Actinobacteria	E	GDSL-like Lipase/Acylhydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2,RicinB_lectin_2
k59_867851_1	1267534.KB906759_gene1695	2.68e-34	134.0	COG4191@1|root,COG4191@2|Bacteria,3Y9CT@57723|Acidobacteria,2JP6N@204432|Acidobacteriia	204432|Acidobacteriia	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,cNMP_binding
k59_1369664_1	402881.Plav_1964	5.83e-108	347.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,2TRHQ@28211|Alphaproteobacteria,1JN5D@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	Glutamate synthase central domain	gltB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_1315048_1	1123392.AQWL01000004_gene2830	8.9e-86	266.0	COG2220@1|root,COG2220@2|Bacteria,1MV20@1224|Proteobacteria,2VKI0@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Zn-dependent hydrolases of the beta-lactamase fold	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
k59_813392_1	83406.HDN1F_19220	1.17e-73	227.0	COG2863@1|root,COG2863@2|Bacteria,1N2NB@1224|Proteobacteria,1RZFP@1236|Gammaproteobacteria,1J6DD@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	COG2863 Cytochrome c553	cc4	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
k59_424058_1	639283.Snov_1999	0.000205	50.1	COG0642@1|root,COG0745@1|root,COG0784@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2TYZQ@28211|Alphaproteobacteria,3F19F@335928|Xanthobacteraceae	28211|Alphaproteobacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_7,PAS_9,Response_reg
k59_1037927_1	485913.Krac_12095	7.01e-35	140.0	COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,2G699@200795|Chloroflexi	200795|Chloroflexi	T	adenylyl cyclase class-3 4 guanylyl cyclase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DZR,Guanylate_cyc
k59_1315054_1	1286106.MPL1_01667	1.12e-126	372.0	COG1805@1|root,COG1805@2|Bacteria,1QTUU@1224|Proteobacteria,1RMGH@1236|Gammaproteobacteria,4607P@72273|Thiotrichales	72273|Thiotrichales	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrB	-	1.6.5.8	ko:K00347	-	-	-	-	ko00000,ko01000	-	-	-	NQR2_RnfD_RnfE
k59_200555_1	1244083.CSUNSWCD_1740	0.000867	40.0	COG1828@1|root,COG1828@2|Bacteria,1N83G@1224|Proteobacteria,42V3S@68525|delta/epsilon subdivisions,2YQ9B@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purS	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	PurS
k59_1037931_1	1235457.C404_11165	2.25e-21	89.4	COG3232@1|root,COG3232@2|Bacteria,1RB8A@1224|Proteobacteria,2VUF8@28216|Betaproteobacteria,1K8A8@119060|Burkholderiaceae	28216|Betaproteobacteria	G	5-carboxymethyl-2-hydroxymuconate isomerase	hpaF	-	5.3.3.10	ko:K01826	ko00350,ko01120,ko01220,map00350,map01120,map01220	M00533	R04379,R04482	RC01141,RC01162	ko00000,ko00001,ko00002,ko01000	-	-	-	CHMI
k59_1037931_2	1122222.AXWR01000001_gene1949	7.92e-63	201.0	COG0346@1|root,COG0346@2|Bacteria,1WICV@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	1.13.11.2	ko:K00446	ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220	M00569	R00816,R04089,R05295,R05404,R05406,R07795	RC00387,RC00643,RC01075,RC01364,RC01914	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase
k59_145356_1	1121468.AUBR01000017_gene2370	4.95e-13	65.9	COG0721@1|root,COG0721@2|Bacteria,1VEK3@1239|Firmicutes,24RIE@186801|Clostridia,42GW8@68295|Thermoanaerobacterales	186801|Clostridia	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
k59_145356_2	1121920.AUAU01000017_gene1235	1.17e-52	173.0	COG0289@1|root,COG0289@2|Bacteria	2|Bacteria	E	4-hydroxy-tetrahydrodipicolinate reductase	dapB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
k59_90381_1	1125863.JAFN01000001_gene890	9.98e-102	307.0	COG0538@1|root,COG0538@2|Bacteria,1MW3J@1224|Proteobacteria,42M56@68525|delta/epsilon subdivisions,2WJ8W@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM isocitrate isopropylmalate dehydrogenase	icd	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
k59_482019_1	317936.Nos7107_0368	1.33e-05	52.4	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1G135@1117|Cyanobacteria,1HK1F@1161|Nostocales	1117|Cyanobacteria	S	PFAM Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_12,TPR_7,TPR_8
k59_1315099_1	338966.Ppro_1378	3.23e-32	125.0	COG3437@1|root,COG3437@2|Bacteria,1RGGM@1224|Proteobacteria,42RTT@68525|delta/epsilon subdivisions,2WNA8@28221|Deltaproteobacteria,43TJF@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Response receiver-modulated cyclic diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	HD,HD_5,Response_reg
k59_1535699_2	1460640.JCM19046_411	6.48e-17	80.9	COG1193@1|root,COG1193@2|Bacteria,1TP5W@1239|Firmicutes,4H9NZ@91061|Bacilli,1ZBJV@1386|Bacillus	91061|Bacilli	L	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity	mutS2	GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_V,Smr
k59_90394_1	309807.SRU_1351	2.32e-56	197.0	COG1165@1|root,COG1165@2|Bacteria,4NETZ@976|Bacteroidetes,1FJ02@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	H	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)	menD	-	2.2.1.9	ko:K02551	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R08165	RC02186	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M_2,TPP_enzyme_N
k59_145380_1	1219084.AP014508_gene132	2.71e-17	83.2	COG0517@1|root,COG0517@2|Bacteria	2|Bacteria	S	IMP dehydrogenase activity	-	-	-	ko:K04767	-	-	-	-	ko00000	-	-	-	CBS
k59_1592107_1	1449350.OCH239_12000	6.24e-110	345.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,2TTPX@28211|Alphaproteobacteria,4KMEG@93682|Roseivivax	28211|Alphaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_368147_1	861299.J421_3870	9.58e-88	270.0	COG0859@1|root,COG0859@2|Bacteria,1ZT3G@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	ko:K12982	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
k59_368147_2	1379270.AUXF01000003_gene3505	0.000652	42.4	COG0859@1|root,COG0859@2|Bacteria,1ZT3G@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	ko:K12982	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
k59_590327_1	1313421.JHBV01000008_gene4466	1.17e-38	144.0	COG1680@1|root,COG1680@2|Bacteria,4NI1Z@976|Bacteroidetes	976|Bacteroidetes	V	COG1680 Beta-lactamase class C and other penicillin binding	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,TPR_2
k59_482047_1	1379270.AUXF01000003_gene3395	2.42e-13	72.4	COG3166@1|root,COG3166@2|Bacteria,1ZTR8@142182|Gemmatimonadetes	142182|Gemmatimonadetes	NU	Fimbrial assembly protein (PilN)	-	-	-	-	-	-	-	-	-	-	-	-	PilN
k59_867960_1	861299.J421_4088	3.17e-69	234.0	COG3408@1|root,COG3408@2|Bacteria	2|Bacteria	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Bac_rhamnosid6H,GDE_C,SLH
k59_1202450_1	521011.Mpal_1764	2.87e-14	79.0	COG0614@1|root,COG3291@1|root,arCOG02508@2157|Archaea,arCOG03611@2157|Archaea	2157|Archaea	P	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,CBM_6,DUF3344,Lipase_GDSL_2,NHL,NosD,PKD,Peptidase_C1,Peptidase_S8
k59_1535718_1	768066.HELO_3149	3.76e-70	223.0	COG0075@1|root,COG0075@2|Bacteria,1QCKV@1224|Proteobacteria,1RQ1T@1236|Gammaproteobacteria,1XIT4@135619|Oceanospirillales	135619|Oceanospirillales	E	Aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
k59_1147953_1	797209.ZOD2009_15486	6.31e-109	322.0	COG0297@1|root,arCOG01420@2157|Archaea,2Y8BY@28890|Euryarchaeota,23UH1@183963|Halobacteria	183963|Halobacteria	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
k59_424129_1	880073.Calab_3046	1.09e-59	207.0	COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,2NNUW@2323|unclassified Bacteria	2|Bacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_20,Fer4_7,Pyr_redox_2,Pyr_redox_3
k59_813465_1	1238182.C882_3662	1.08e-17	84.7	COG0477@1|root,COG2814@2|Bacteria,1MVZI@1224|Proteobacteria,2U5H1@28211|Alphaproteobacteria,2JRQN@204441|Rhodospirillales	204441|Rhodospirillales	EGP	COG0477 Permeases of the major facilitator superfamily	-	-	-	ko:K05820	-	-	-	-	ko00000,ko02000	2.A.1.27	-	-	MFS_1_like
k59_813465_2	1504981.KO116_3428	0.000213	44.3	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1XH3T@135619|Oceanospirillales	135619|Oceanospirillales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1038078_1	1217720.ALOX01000099_gene574	1.92e-10	66.2	COG1566@1|root,COG1566@2|Bacteria,1MU7I@1224|Proteobacteria,2TS39@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	PFAM secretion protein HlyD family protein	-	-	-	ko:K03543	-	M00701	-	-	ko00000,ko00002,ko02000	8.A.1.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
k59_145432_1	1328313.DS2_18168	9.22e-84	278.0	COG3250@1|root,COG3250@2|Bacteria,1MVBN@1224|Proteobacteria,1RMER@1236|Gammaproteobacteria,4654R@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	Belongs to the glycosyl hydrolase 2 family	-	-	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	Bgal_small_N,DUF4981,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
k59_1315245_1	998674.ATTE01000001_gene1496	0.00013	44.3	COG0607@1|root,COG0607@2|Bacteria,1PH28@1224|Proteobacteria,1SWJ9@1236|Gammaproteobacteria,461CK@72273|Thiotrichales	72273|Thiotrichales	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_316099_1	671143.DAMO_2352	3.56e-42	150.0	COG0451@1|root,COG0451@2|Bacteria	2|Bacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	yeeZ	-	1.5.5.1	ko:K00311	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase,NAD_binding_10,RmlD_sub_bind
k59_1317240_1	1120983.KB894570_gene1383	3.85e-58	202.0	COG0591@1|root,COG0642@1|root,COG0591@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,2TR1M@28211|Alphaproteobacteria,1JNF1@119043|Rhodobiaceae	28211|Alphaproteobacteria	T	His Kinase A (phosphoacceptor) domain	resE	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_7,Response_reg,SSF
k59_983783_1	1054213.HMPREF9946_01432	2.08e-09	62.4	COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,2TSZ0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	COG0402 Cytosine deaminase and related metal-dependent hydrolases	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_870141_1	1237149.C900_03270	2.5e-08	56.2	COG0843@1|root,COG0843@2|Bacteria,4NEH8@976|Bacteroidetes,47JBQ@768503|Cytophagia	976|Bacteroidetes	C	Belongs to the heme-copper respiratory oxidase family	coxN	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_870141_2	314230.DSM3645_19533	2.47e-30	115.0	COG1622@1|root,COG1622@2|Bacteria,2IZBI@203682|Planctomycetes	203682|Planctomycetes	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM
k59_258302_1	420324.KI912035_gene2494	5.51e-70	216.0	COG3335@1|root,COG3335@2|Bacteria,1MW7X@1224|Proteobacteria,2TTH8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG3335 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
k59_1149779_1	378806.STAUR_4753	7.07e-78	243.0	COG1573@1|root,COG1573@2|Bacteria,1MWX1@1224|Proteobacteria,42QXV@68525|delta/epsilon subdivisions,2WMXB@28221|Deltaproteobacteria,2YUZZ@29|Myxococcales	28221|Deltaproteobacteria	L	Uracil-DNA glycosylase	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
k59_592246_1	861299.J421_2666	1.09e-98	306.0	COG0508@1|root,COG0508@2|Bacteria,1ZSYJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_1040092_1	81824.XP_001746840.1	9.42e-42	153.0	COG0133@1|root,COG0159@1|root,KOG1395@2759|Eukaryota,KOG4175@2759|Eukaryota,38GS5@33154|Opisthokonta	33154|Opisthokonta	E	tryptophan synthase	-	-	4.2.1.20	ko:K01694,ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,PRAI,Trp_syntA
k59_1040092_2	261292.Nit79A3_2469	3.73e-24	99.0	COG0159@1|root,COG0159@2|Bacteria,1MXJV@1224|Proteobacteria,2VI78@28216|Betaproteobacteria,3725B@32003|Nitrosomonadales	28216|Betaproteobacteria	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
k59_92231_1	324057.Pjdr2_2588	5.57e-92	282.0	COG0304@1|root,COG0304@2|Bacteria,1TPA7@1239|Firmicutes,4H9SD@91061|Bacilli,26QJA@186822|Paenibacillaceae	91061|Bacilli	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_705100_1	1444309.JAQG01000100_gene4694	2.16e-59	191.0	COG0346@1|root,COG2185@1|root,COG0346@2|Bacteria,COG2185@2|Bacteria,1V5GM@1239|Firmicutes,4HH66@91061|Bacilli,26S25@186822|Paenibacillaceae	91061|Bacilli	E	Lactoylglutathione lyase	-	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
k59_1149799_1	86106.I862_06140	1.77e-29	112.0	COG1905@1|root,COG1905@2|Bacteria,1MWS2@1224|Proteobacteria,2TSEJ@28211|Alphaproteobacteria,47F8V@766|Rickettsiales	766|Rickettsiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)	nuoE	-	1.6.5.3,1.6.99.3	ko:K00334,ko:K03943	ko00190,ko01100,ko04714,ko04723,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04714,map04723,map04932,map05010,map05012,map05016	M00143,M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1,3.D.1.6	-	-	2Fe-2S_thioredx
k59_929216_1	1194165.CAJF01000019_gene2858	3.93e-28	105.0	COG0596@1|root,COG0596@2|Bacteria,2GU04@201174|Actinobacteria	201174|Actinobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1262156_1	398767.Glov_1657	1.03e-73	237.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,43UCF@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	response regulator	pilR	-	-	ko:K02667	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_258343_1	1121945.ATXS01000001_gene2338	3.55e-12	71.6	COG0591@1|root,arCOG01316@2157|Archaea,2XU91@28890|Euryarchaeota,23TIG@183963|Halobacteria	183963|Halobacteria	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K11928	-	-	-	-	ko00000,ko02000	2.A.21.2	-	-	SSF
k59_36302_1	1304877.KI519399_gene4008	4.24e-20	89.4	COG0329@1|root,COG0329@2|Bacteria,1MV7E@1224|Proteobacteria,2TTT5@28211|Alphaproteobacteria,3JUG4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EM	Protein of unknown function (DUF993)	MA20_16880	-	-	-	-	-	-	-	-	-	-	-	DUF993
k59_36302_2	1217720.ALOX01000019_gene759	3.09e-67	214.0	COG0673@1|root,COG0673@2|Bacteria,1PYTN@1224|Proteobacteria,2TS0G@28211|Alphaproteobacteria,2JUXJ@204441|Rhodospirillales	204441|Rhodospirillales	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
k59_1706715_1	272943.RSP_2963	3.54e-05	49.7	COG0664@1|root,COG0664@2|Bacteria,1R6BV@1224|Proteobacteria,2TU8X@28211|Alphaproteobacteria,1FBS5@1060|Rhodobacter	28211|Alphaproteobacteria	K	PFAM Cyclic nucleotide-binding	-	-	-	ko:K01420,ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
k59_1647248_1	1266925.JHVX01000003_gene568	1.12e-56	188.0	COG2377@1|root,COG2377@2|Bacteria,1MV4E@1224|Proteobacteria,2VHCE@28216|Betaproteobacteria,372PY@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling	anmK	-	2.7.1.170	ko:K09001	-	-	-	-	ko00000,ko01000	-	-	-	AnmK
k59_1758736_1	192952.MM_2598	1.47e-05	52.4	COG0145@1|root,arCOG01517@2157|Archaea	2157|Archaea	EQ	5-oxoprolinase (ATP-hydrolyzing) activity	-	-	-	-	-	-	-	-	-	-	-	-	Hydant_A_N,Hydantoinase_A
k59_316177_1	469371.Tbis_0648	8.98e-37	138.0	COG1983@1|root,COG4585@1|root,COG1983@2|Bacteria,COG4585@2|Bacteria,2GJ4J@201174|Actinobacteria,4DXQC@85010|Pseudonocardiales	201174|Actinobacteria	T	Histidine kinase	tcsS3	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HATPase_c_2,PspC
k59_592298_2	926569.ANT_05250	3.7e-07	50.8	COG3346@1|root,COG3346@2|Bacteria	2|Bacteria	S	mitochondrial respiratory chain complex IV assembly	surf1	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704,GO:0071944	-	ko:K14998	-	-	-	-	ko00000,ko03029	3.D.4.8	-	-	SURF1
k59_1500042_2	1123228.AUIH01000024_gene3247	1.96e-23	92.0	COG0091@1|root,COG0091@2|Bacteria,1RH0W@1224|Proteobacteria,1S5XT@1236|Gammaproteobacteria,1XK4T@135619|Oceanospirillales	135619|Oceanospirillales	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
k59_51185_1	926569.ANT_00600	1.19e-34	119.0	COG0291@1|root,COG0291@2|Bacteria	2|Bacteria	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
k59_51185_2	926569.ANT_00590	2.7e-48	156.0	COG0292@1|root,COG0292@2|Bacteria,2G6V4@200795|Chloroflexi	200795|Chloroflexi	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
k59_1109341_1	1123368.AUIS01000024_gene950	0.000329	42.7	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,1SYDD@1236|Gammaproteobacteria,2NCJF@225057|Acidithiobacillales	225057|Acidithiobacillales	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
k59_1109341_2	1121920.AUAU01000004_gene687	7.63e-40	145.0	COG0842@1|root,COG0842@2|Bacteria,3Y4H7@57723|Acidobacteria	57723|Acidobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
k59_1218654_1	1423747.BAMJ01000049_gene2115	1.3e-18	84.3	COG4806@1|root,COG4806@2|Bacteria,1TS42@1239|Firmicutes,4HBQP@91061|Bacilli,3F5GK@33958|Lactobacillaceae	91061|Bacilli	G	L-rhamnose isomerase (RhaA)	rhaA	GO:0003674,GO:0003824,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0008740,GO:0009056,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019299,GO:0019301,GO:0019318,GO:0019320,GO:0019321,GO:0019324,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0071704,GO:1901575	2.7.1.5,5.3.1.14	ko:K00848,ko:K01813	ko00040,ko00051,ko01120,map00040,map00051,map01120	-	R01902,R02437,R03014	RC00002,RC00017,RC00434	ko00000,ko00001,ko01000	-	-	-	RhaA
k59_1218654_2	1303518.CCALI_01718	2.19e-61	196.0	COG0235@1|root,COG0235@2|Bacteria	2|Bacteria	G	Class ii aldolase	rhaD	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0008994,GO:0009056,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0019299,GO:0019301,GO:0019318,GO:0019320,GO:0019321,GO:0019323,GO:0042802,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0071704,GO:1901575	4.1.2.17,4.1.2.19	ko:K01628,ko:K01629	ko00040,ko00051,ko01120,map00040,map00051,map01120	-	R01785,R02262,R02263	RC00438,RC00599,RC00603,RC00604	ko00000,ko00001,ko01000	-	-	iECH74115_1262.ECH74115_5354,iECSP_1301.ECSP_4963,iECs_1301.ECs4829,iLF82_1304.LF82_1866,iNRG857_1313.NRG857_19475,iSFV_1184.SFV_3593,iSSON_1240.SSON_4072,iYL1228.KPN_04211,iZ_1308.Z5446,ic_1306.c4851	Aldolase_II
k59_1055095_1	1166018.FAES_0331	4.03e-97	290.0	COG3967@1|root,COG3967@2|Bacteria,4NJUM@976|Bacteroidetes,47MKC@768503|Cytophagia	976|Bacteroidetes	M	KR domain	-	-	-	ko:K14189	-	-	-	-	ko00000,ko01000	-	-	-	adh_short
k59_441400_1	1150626.PHAMO_40086	6.2e-51	171.0	COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,2TU5X@28211|Alphaproteobacteria,2JPK0@204441|Rhodospirillales	204441|Rhodospirillales	M	Belongs to the SIS family. GutQ KpsF subfamily	kpsF	-	5.3.1.13	ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CBS,SIS
k59_830584_1	671143.DAMO_2709	1.23e-29	114.0	COG1005@1|root,COG1005@2|Bacteria,2NQIK@2323|unclassified Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016491,GO:0016651,GO:0016655,GO:0044237,GO:0045333,GO:0050136,GO:0055114	1.6.5.3	ko:K00337,ko:K05572	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
k59_830584_2	999611.KI421504_gene2254	2.47e-18	85.1	COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,2TQZ0@28211|Alphaproteobacteria,2802A@191028|Leisingera	28211|Alphaproteobacteria	C	Respiratory-chain NADH dehydrogenase, 49 Kd subunit	nuoD	GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
k59_386103_1	1089552.KI911559_gene661	3.09e-59	189.0	COG0745@1|root,COG0745@2|Bacteria,1MVCB@1224|Proteobacteria,2TR43@28211|Alphaproteobacteria,2JQU8@204441|Rhodospirillales	204441|Rhodospirillales	T	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	chvI	-	-	ko:K14981	ko02020,map02020	M00520	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_1720283_1	479434.Sthe_3372	8.7e-07	53.9	COG2079@1|root,COG2079@2|Bacteria,2G8X4@200795|Chloroflexi,27Z98@189775|Thermomicrobia	189775|Thermomicrobia	S	MmgE/PrpD family	-	-	4.2.1.79	ko:K01720	ko00640,map00640	-	R04424	RC01152	ko00000,ko00001,ko01000	-	-	-	MmgE_PrpD
k59_272179_1	861299.J421_6359	9.62e-31	125.0	COG0577@1|root,COG0577@2|Bacteria	861299.J421_6359|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1500092_1	338966.Ppro_0646	5.14e-15	79.0	COG0457@1|root,COG0457@2|Bacteria,1NSRW@1224|Proteobacteria,42YBG@68525|delta/epsilon subdivisions,2WTZ6@28221|Deltaproteobacteria,43TDF@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19
k59_997778_1	558152.IQ37_10725	9.11e-30	111.0	COG0580@1|root,COG0580@2|Bacteria,4NEFK@976|Bacteroidetes,1HYTU@117743|Flavobacteriia,3ZNPT@59732|Chryseobacterium	976|Bacteroidetes	U	Belongs to the MIP aquaporin (TC 1.A.8) family	glpF	-	-	ko:K02440	-	-	-	-	ko00000,ko02000	1.A.8.1,1.A.8.2	-	-	MIP
k59_997778_2	1189620.AJXL01000027_gene3371	5.41e-41	148.0	COG0554@1|root,COG0554@2|Bacteria,4NFUH@976|Bacteroidetes,1HX3Z@117743|Flavobacteriia,2P04G@237|Flavobacterium	976|Bacteroidetes	C	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
k59_51247_1	1121346.KB899810_gene1510	3.52e-63	219.0	COG0587@1|root,COG0587@2|Bacteria,1TPYG@1239|Firmicutes,4H9T3@91061|Bacilli,26QTS@186822|Paenibacillaceae	91061|Bacilli	L	DNA polymerase	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_1218691_2	936574.HMPREF1508_1576	1.24e-09	63.5	COG0750@1|root,COG0750@2|Bacteria,1TPMC@1239|Firmicutes,247MT@186801|Clostridia	186801|Clostridia	M	zinc metalloprotease	rseP	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
k59_500307_1	1122134.KB893650_gene630	3.56e-18	88.6	COG2831@1|root,COG2831@2|Bacteria,1QUVE@1224|Proteobacteria,1T229@1236|Gammaproteobacteria,1XRZ6@135619|Oceanospirillales	135619|Oceanospirillales	U	hemolysin activation secretion protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_107342_1	370438.PTH_1452	1.91e-34	128.0	COG4965@1|root,COG4965@2|Bacteria,1UZ3V@1239|Firmicutes,25D46@186801|Clostridia,260VX@186807|Peptococcaceae	186801|Clostridia	U	PFAM type II secretion system	-	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
k59_1218704_1	997296.PB1_06477	3.49e-18	79.0	COG0103@1|root,COG0103@2|Bacteria,1V3MQ@1239|Firmicutes,4HH3B@91061|Bacilli,1ZG6R@1386|Bacillus	91061|Bacilli	J	Belongs to the universal ribosomal protein uS9 family	rpsI	GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
k59_1218704_2	871963.Desdi_0067	1.88e-08	57.4	COG1694@1|root,COG3956@2|Bacteria,1TPK1@1239|Firmicutes,247XM@186801|Clostridia,2613S@186807|Peptococcaceae	186801|Clostridia	S	TIGRFAM MazG family protein	mazG	-	3.6.1.66	ko:K02428,ko:K02499	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000,ko03036	-	-	-	MazG,TP_methylase
k59_1055165_2	344747.PM8797T_18624	0.000565	41.2	COG2835@1|root,COG2835@2|Bacteria	2|Bacteria	EG	tetraacyldisaccharide 4'-kinase activity	ycaR	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	2.7.1.130	ko:K00912,ko:K09791	ko00540,ko01100,map00540,map01100	M00060	R04657	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Trm112p
k59_830665_1	1370121.AUWS01000078_gene693	1.37e-05	51.2	COG3187@1|root,COG3187@2|Bacteria,2I9ND@201174|Actinobacteria,232P4@1762|Mycobacteriaceae	201174|Actinobacteria	O	META domain	hslJ	-	-	ko:K03668	-	-	-	-	ko00000	-	-	-	META
k59_386149_1	1189612.A33Q_0002	3.87e-21	95.9	COG1404@1|root,COG1404@2|Bacteria,4NFFV@976|Bacteroidetes,47JYC@768503|Cytophagia	976|Bacteroidetes	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
k59_1550943_1	870187.Thini_0858	1.77e-40	142.0	COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,1RQ1J@1236|Gammaproteobacteria,460UF@72273|Thiotrichales	72273|Thiotrichales	K	PFAM Response regulator receiver domain	-	-	-	ko:K07689	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	M00475	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
k59_1055186_1	314278.NB231_14438	3.98e-104	319.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,1RN7X@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	acyl-CoA dehydrogenase	aidB	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003995,GO:0005488,GO:0005515,GO:0006355,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008470,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016491,GO:0016627,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0033554,GO:0042802,GO:0043565,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0055114,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K09456	-	-	-	-	ko00000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M
k59_1218723_1	926550.CLDAP_06530	7.19e-42	149.0	COG0006@1|root,COG0006@2|Bacteria,2G5J8@200795|Chloroflexi	200795|Chloroflexi	E	PFAM peptidase M24	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M24
k59_500351_1	1105031.HMPREF1141_2647	5.71e-08	52.0	COG0636@1|root,COG0636@2|Bacteria,1VF4U@1239|Firmicutes,25CR4@186801|Clostridia,36WZH@31979|Clostridiaceae	186801|Clostridia	C	ATP synthase subunit C	ntpK	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
k59_500351_2	1123075.AUDP01000012_gene3552	6.72e-10	58.9	COG1436@1|root,COG1436@2|Bacteria,1VEN1@1239|Firmicutes,24K2E@186801|Clostridia,3WJWV@541000|Ruminococcaceae	186801|Clostridia	C	Archaeal vacuolar-type H -ATPase subunit F	-	-	-	ko:K02122	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_F
k59_1166804_1	314285.KT71_01255	2.02e-15	81.3	COG1521@1|root,COG1521@2|Bacteria,1MUYA@1224|Proteobacteria,1S99V@1236|Gammaproteobacteria,1J927@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Pan_kinase
k59_107381_1	1463856.JOHY01000013_gene6159	2.56e-21	93.2	COG2203@1|root,COG2203@2|Bacteria,2I97I@201174|Actinobacteria	201174|Actinobacteria	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2
k59_441522_1	1049564.TevJSym_ab01790	2.19e-67	219.0	COG0265@1|root,COG3016@1|root,COG0265@2|Bacteria,COG3016@2|Bacteria,1MX1I@1224|Proteobacteria,1RPWZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Iron-regulated protein	-	-	-	-	-	-	-	-	-	-	-	-	Cofac_haem_bdg,PDZ_2
k59_107389_1	861299.J421_2396	5.46e-42	155.0	COG0188@1|root,COG0188@2|Bacteria,1ZTFF@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_163420_1	1395571.TMS3_0106300	3.08e-13	65.5	COG4392@1|root,COG4392@2|Bacteria,1NH6U@1224|Proteobacteria,1SGUY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	branched-chain amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AzlD
k59_163420_2	526227.Mesil_1415	1.45e-27	108.0	COG1296@1|root,COG1296@2|Bacteria	2|Bacteria	E	L-valine transmembrane transporter activity	azlC	-	-	-	-	-	-	-	-	-	-	-	AzlC
k59_608019_1	314345.SPV1_09593	3.28e-36	127.0	2ETWY@1|root,32VZU@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_444027_1	926569.ANT_15160	1.06e-52	184.0	COG0515@1|root,COG1520@1|root,COG0515@2|Bacteria,COG1520@2|Bacteria,2G5NM@200795|Chloroflexi	200795|Chloroflexi	KLT	Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PQQ_3,Pkinase
k59_274325_1	716928.AJQT01000039_gene1468	2.45e-12	67.4	COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,2TSH9@28211|Alphaproteobacteria,4BAAI@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	ABC transporter	-	-	-	ko:K02049,ko:K15555,ko:K15578	ko00910,ko00920,ko02010,map00910,map00920,map02010	M00188,M00436,M00438	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.16,3.A.1.16.1,3.A.1.17,3.A.1.17.2	-	-	ABC_tran
k59_274325_2	706587.Desti_0199	8.75e-53	170.0	COG1513@1|root,COG1513@2|Bacteria,1R9X0@1224|Proteobacteria	1224|Proteobacteria	P	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide	cynS	-	4.2.1.104	ko:K01725	ko00910,map00910	-	R03546,R10079	RC00952	ko00000,ko00001,ko01000	-	-	-	Cyanate_lyase
k59_663788_1	314292.VAS14_03998	1.56e-06	52.0	COG3070@1|root,COG3070@2|Bacteria,1RDWD@1224|Proteobacteria,1S496@1236|Gammaproteobacteria,1XUVA@135623|Vibrionales	135623|Vibrionales	K	COG3070 Regulator of competence-specific genes	tfoX	GO:0006810,GO:0007154,GO:0008150,GO:0009290,GO:0009292,GO:0009294,GO:0009605,GO:0009987,GO:0009991,GO:0015931,GO:0030420,GO:0031668,GO:0044764,GO:0050657,GO:0050896,GO:0051027,GO:0051179,GO:0051234,GO:0051704,GO:0051716,GO:0071496,GO:0071702,GO:0071705,GO:0098657	-	ko:K07343	-	-	-	-	ko00000	-	-	-	TfoX_C,TfoX_N
k59_217756_2	598467.BrE312_2776	2.47e-114	343.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,1RQ9W@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	to Escherichia coli transposase for insertion sequence element IS21 IstA SW ISTA_ECOLI (P15025) (390 aa) fasta scores E() 3e-27, 33.1 id in 329 aa. Identical to the previously sequenced Yersinia pestis,Yersinia pseudotuberculosis and Escherichia coli pesticin plasmid insertion sequence transposase Y1055 TR P74993 (EMBL U59875) (340 aa) fasta scores E() 0, 100.0 id in 340 aa	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,rve
k59_833300_1	1121033.AUCF01000012_gene941	3.11e-78	244.0	COG0683@1|root,COG0683@2|Bacteria,1NNXR@1224|Proteobacteria,2VEZD@28211|Alphaproteobacteria,2JVTF@204441|Rhodospirillales	204441|Rhodospirillales	E	Receptor family ligand binding region	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
k59_165771_1	1131269.AQVV01000006_gene491	3.62e-39	142.0	COG0649@1|root,COG0649@2|Bacteria	2|Bacteria	C	NAD binding	nuoD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0044424,GO:0044464,GO:0071944	1.6.5.3	ko:K00333,ko:K13378	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa,Complex1_49kDa
k59_165771_2	1487923.DP73_07795	3.33e-19	82.4	COG0852@1|root,COG0852@2|Bacteria,1UFNI@1239|Firmicutes,24GTJ@186801|Clostridia,262SJ@186807|Peptococcaceae	186801|Clostridia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
k59_1553133_1	247490.KSU1_D0514	5.67e-05	52.0	COG3055@1|root,COG3204@1|root,COG3055@2|Bacteria,COG3204@2|Bacteria	2|Bacteria	L	pilus organization	-	-	-	ko:K02674,ko:K07004	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Big_5,Exo_endo_phos,He_PIG,HemolysinCabind,LTD,Laminin_G_3,Malectin,PA14
k59_217808_1	479434.Sthe_1253	1.33e-99	298.0	COG0057@1|root,COG0057@2|Bacteria,2G5MG@200795|Chloroflexi,27Y38@189775|Thermomicrobia	189775|Thermomicrobia	C	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	-	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
k59_165820_1	694440.JOMF01000005_gene342	5.87e-57	186.0	COG0177@1|root,arCOG00459@2157|Archaea,2XTY1@28890|Euryarchaeota,2N9S3@224756|Methanomicrobia	224756|Methanomicrobia	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
k59_553713_1	998088.B565_1296	2.8e-47	169.0	COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,1RPQG@1236|Gammaproteobacteria,1Y439@135624|Aeromonadales	135624|Aeromonadales	I	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	cls	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2,PLDc_N
k59_165822_1	1223523.H340_12350	1.03e-71	221.0	COG2353@1|root,COG2353@2|Bacteria,2IEYU@201174|Actinobacteria	201174|Actinobacteria	S	YceI-like domain	-	-	-	-	-	-	-	-	-	-	-	-	YceI
k59_1778303_1	1150474.JQJI01000025_gene1664	5.77e-28	109.0	COG1394@1|root,COG1394@2|Bacteria,2GD6P@200918|Thermotogae	200918|Thermotogae	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	-	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
k59_1665034_1	857087.Metme_1420	1.87e-85	278.0	COG2373@1|root,COG2373@2|Bacteria,1Q2SN@1224|Proteobacteria,1S1CA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	Animal haem peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	An_peroxidase
k59_1778310_1	46429.BV95_00704	4.09e-76	228.0	COG1943@1|root,COG1943@2|Bacteria,1MX19@1224|Proteobacteria,2UB1M@28211|Alphaproteobacteria,2K4EK@204457|Sphingomonadales	204457|Sphingomonadales	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
k59_1778310_2	1219049.SP5_098_00490	9.68e-19	79.7	COG1943@1|root,COG1943@2|Bacteria,1MX19@1224|Proteobacteria,2UB1M@28211|Alphaproteobacteria,2K4EK@204457|Sphingomonadales	204457|Sphingomonadales	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
k59_1444984_1	886293.Sinac_0736	2.6e-55	195.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,2IYAH@203682|Planctomycetes	203682|Planctomycetes	C	FAD linked oxidases, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17,Fer4_8
k59_388290_1	379066.GAU_0505	0.000522	43.9	COG0843@1|root,COG0843@2|Bacteria,1ZSMG@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_388290_2	1379270.AUXF01000002_gene1827	5.48e-29	111.0	COG1845@1|root,COG1845@2|Bacteria,1ZT8Q@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Cytochrome c oxidase subunit III	-	-	1.9.3.1	ko:K02276,ko:K02299	ko00190,ko01100,map00190,map01100	M00155,M00417	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.5,3.D.4.6	-	-	COX3
k59_1778335_1	1001585.MDS_3045	1.42e-48	177.0	COG2304@1|root,COG2931@1|root,COG2304@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,1S3Q4@1236|Gammaproteobacteria,1YG4I@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,DUF4114,HemolysinCabind,VWA_2
k59_999668_2	70601.3258002	2.46e-26	107.0	COG0309@1|root,arCOG00636@2157|Archaea,2XTX2@28890|Euryarchaeota,242XP@183968|Thermococci	183968|Thermococci	O	AIR synthase related protein, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AIRS,AIRS_C
k59_775744_1	335543.Sfum_0905	4.24e-59	199.0	COG4143@1|root,COG4143@2|Bacteria,1R4IE@1224|Proteobacteria,42QHK@68525|delta/epsilon subdivisions,2WUK2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	(ABC) transporter	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_999671_1	1121413.JMKT01000009_gene2096	1.2e-09	60.1	COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,42MR7@68525|delta/epsilon subdivisions,2WIKA@28221|Deltaproteobacteria,2M9JU@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	PFAM Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,Na_sulph_symp,TrkA_C
k59_999671_2	926569.ANT_00270	1.66e-39	143.0	COG0044@1|root,COG0044@2|Bacteria,2G5N4@200795|Chloroflexi	200795|Chloroflexi	F	Amidohydrolase family	-	-	3.5.2.2,3.5.2.5	ko:K01464,ko:K01466	ko00230,ko00240,ko00410,ko00770,ko00983,ko01100,ko01120,map00230,map00240,map00410,map00770,map00983,map01100,map01120	M00046,M00546	R02269,R02425,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Amidohydro_1
k59_444161_1	391937.NA2_00770	1.06e-07	53.5	COG0384@1|root,COG0384@2|Bacteria,1MUAS@1224|Proteobacteria,2U3ND@28211|Alphaproteobacteria,43HUF@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Phenazine biosynthesis protein PhzF	phzF	-	5.3.3.17	ko:K06998	ko00405,ko01130,ko02024,map00405,map01130,map02024	M00835	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	PhzC-PhzF
k59_444161_2	1246448.ANAZ01000027_gene3535	2.64e-53	177.0	COG2141@1|root,COG2141@2|Bacteria,2GJRF@201174|Actinobacteria,4EM0W@85012|Streptosporangiales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_833430_1	63737.Npun_R3027	3.06e-78	261.0	COG0001@1|root,COG0318@1|root,COG1020@1|root,COG3321@1|root,COG0001@2|Bacteria,COG0318@2|Bacteria,COG1020@2|Bacteria,COG3321@2|Bacteria,1FZXE@1117|Cyanobacteria,1HIST@1161|Nostocales	1117|Cyanobacteria	Q	acyl transferase domain	-	-	-	ko:K16129	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Aminotran_3,Bac_luciferase,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,ketoacyl-synt
k59_53752_1	1238182.C882_2918	5.55e-81	265.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,2USBB@28211|Alphaproteobacteria,2JQFN@204441|Rhodospirillales	204441|Rhodospirillales	M	penicillin-binding protein 1A	mrcA	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	PCB_OB,Transgly,Transpeptidase
k59_833436_1	1500257.JQNM01000014_gene2913	1.51e-92	286.0	COG0654@1|root,COG0654@2|Bacteria,1MUN4@1224|Proteobacteria,2TRHJ@28211|Alphaproteobacteria,4B8QN@82115|Rhizobiaceae	28211|Alphaproteobacteria	CH	FAD binding domain	MA20_44090	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
k59_775757_1	926569.ANT_28720	1.21e-97	288.0	COG0745@1|root,COG0745@2|Bacteria,2G5TG@200795|Chloroflexi	200795|Chloroflexi	K	Two component transcriptional regulator, winged helix family	-	-	-	ko:K07669	ko02020,map02020	M00460	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_444195_1	926566.Terro_2344	4.6e-18	85.1	COG0497@1|root,COG0497@2|Bacteria,3Y2J4@57723|Acidobacteria,2JI9C@204432|Acidobacteriia	204432|Acidobacteriia	L	May be involved in recombinational repair of damaged DNA	-	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	SMC_N
k59_344863_2	1415756.JQMY01000001_gene600	3.89e-21	91.3	COG0715@1|root,COG0715@2|Bacteria,1MVRA@1224|Proteobacteria,2TQPE@28211|Alphaproteobacteria,2PDDW@252301|Oceanicola	28211|Alphaproteobacteria	P	NMT1/THI5 like	-	-	-	ko:K15598	ko02010,map02010	M00442	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.17.3,3.A.1.17.6	-	-	NMT1
k59_344873_1	1297742.A176_04241	1.42e-22	101.0	COG0577@1|root,COG0577@2|Bacteria,1NREW@1224|Proteobacteria	1224|Proteobacteria	V	COG0577 ABC-type antimicrobial peptide transport system permease component	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_1290202_1	56780.SYN_02762	1.92e-26	112.0	COG1624@1|root,COG4856@1|root,COG1624@2|Bacteria,COG4856@2|Bacteria,1PEQT@1224|Proteobacteria,42P5A@68525|delta/epsilon subdivisions,2WKPP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria	dacA	-	-	-	-	-	-	-	-	-	-	-	DisA_N,YbbR
k59_234208_1	1288826.MSNKSG1_11728	1.98e-126	377.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RME8@1236|Gammaproteobacteria,464T9@72275|Alteromonadaceae	1236|Gammaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	GO:0000166,GO:0003674,GO:0003824,GO:0004175,GO:0004176,GO:0004222,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009056,GO:0009057,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030145,GO:0030163,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043273,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_456655_1	338969.Rfer_1460	0.000417	48.5	COG0715@1|root,COG0715@2|Bacteria,1MVZE@1224|Proteobacteria,2VJ88@28216|Betaproteobacteria,4A9W3@80864|Comamonadaceae	28216|Betaproteobacteria	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
k59_511879_1	1064535.MELS_1461	4.47e-37	141.0	COG0606@1|root,COG0606@2|Bacteria,1TPPB@1239|Firmicutes,4H1VZ@909932|Negativicutes	909932|Negativicutes	O	Mg chelatase-like protein	comM	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
k59_456666_2	1121129.KB903360_gene3626	8.69e-16	79.0	COG0438@1|root,COG0438@2|Bacteria,4NE6S@976|Bacteroidetes,2FS76@200643|Bacteroidia,22XPD@171551|Porphyromonadaceae	976|Bacteroidetes	M	glycosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4
k59_178235_1	518766.Rmar_1087	3.38e-16	80.9	2DBWZ@1|root,2ZBKJ@2|Bacteria,4NMS8@976|Bacteroidetes,1FK4J@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	HmuY protein	-	-	-	-	-	-	-	-	-	-	-	-	HmuY
k59_1401528_1	331113.SNE_A12280	2.81e-60	202.0	COG0531@1|root,COG0531@2|Bacteria,2JH4M@204428|Chlamydiae	204428|Chlamydiae	E	Catalyzes the exchange of L-arginine for agmatine. The arginine uptake by the bacterium in the macrophage may be a virulence factor against the host innate immune response	aaxC	-	-	ko:K03294,ko:K03758	-	-	-	-	ko00000,ko02000	2.A.3.2	-	-	AA_permease_2
k59_1179223_1	279714.FuraDRAFT_3188	3.75e-28	111.0	COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,2VKKS@28216|Betaproteobacteria,2KTTX@206351|Neisseriales	206351|Neisseriales	C	Cytochrome c oxidase subunit III	-	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
k59_1345780_1	880073.Calab_1196	2.16e-60	209.0	COG0841@1|root,COG0841@2|Bacteria,2NNUH@2323|unclassified Bacteria	2|Bacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_790265_1	765912.Thimo_1054	5.72e-61	208.0	COG2225@1|root,COG2225@2|Bacteria,1MVEV@1224|Proteobacteria,1RPVI@1236|Gammaproteobacteria,1WXV7@135613|Chromatiales	135613|Chromatiales	C	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA	glcB	-	2.3.3.9	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472	RC00004,RC00308,RC02747	ko00000,ko00001,ko00002,ko01000	-	-	-	Malate_synthase
k59_456710_1	861299.J421_6180	2.64e-28	118.0	COG0577@1|root,COG0577@2|Bacteria	861299.J421_6180|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1457533_1	1123376.AUIU01000015_gene488	1.37e-51	177.0	COG0612@1|root,COG0612@2|Bacteria,3J0I5@40117|Nitrospirae	40117|Nitrospirae	S	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_289862_1	309801.trd_A0200	1.4e-64	211.0	COG1350@1|root,COG1350@2|Bacteria,2G5YY@200795|Chloroflexi,27XSD@189775|Thermomicrobia	189775|Thermomicrobia	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	-	-	4.2.1.20	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_511943_1	1128421.JAGA01000002_gene1099	1.1e-21	93.6	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	M1-584	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
k59_122578_1	592031.GCWU000322_00520	2.08e-62	205.0	COG0541@1|root,COG0541@2|Bacteria,1TP06@1239|Firmicutes,248EU@186801|Clostridia,25V24@186806|Eubacteriaceae	186801|Clostridia	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
k59_567408_1	234267.Acid_4736	7.92e-57	196.0	COG0457@1|root,COG0457@2|Bacteria,3Y3RA@57723|Acidobacteria	57723|Acidobacteria	M	SMART Tetratricopeptide	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2,TPR_1,TPR_11,TPR_16,TPR_17,TPR_2,TPR_8
k59_1290290_1	309807.SRU_0982	1.19e-21	93.6	COG5505@1|root,COG5505@2|Bacteria,4NE2H@976|Bacteroidetes,1FJQG@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Protein of unknown function (DUF819)	-	-	-	-	-	-	-	-	-	-	-	-	DUF819
k59_234296_1	1089551.KE386572_gene1120	4.24e-85	255.0	COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,4BRE0@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	L	HTH-like domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
k59_845276_1	469371.Tbis_0583	1.02e-26	104.0	COG0563@1|root,COG0563@2|Bacteria,2GJ7T@201174|Actinobacteria,4DXX8@85010|Pseudonocardiales	201174|Actinobacteria	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
k59_845276_2	498761.HM1_1400	9.81e-85	259.0	COG0024@1|root,COG0024@2|Bacteria,1TQC1@1239|Firmicutes,248I8@186801|Clostridia	186801|Clostridia	E	Methionine aminopeptidase	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
k59_1457570_1	459495.SPLC1_S370990	7.44e-12	63.9	COG0745@1|root,COG0745@2|Bacteria,1FZWD@1117|Cyanobacteria,1HA1B@1150|Oscillatoriales	1117|Cyanobacteria	T	PFAM Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
k59_67259_1	1205680.CAKO01000038_gene1664	4.25e-78	241.0	COG0601@1|root,COG0601@2|Bacteria,1R6TQ@1224|Proteobacteria,2VFHW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
k59_790334_1	1267600.JFGT01000004_gene3405	5.8e-28	109.0	COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,1RPHK@1236|Gammaproteobacteria,3VZDX@53335|Pantoea	1236|Gammaproteobacteria	C	it plays a direct role in the translocation of protons across the membrane	atpB	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016021,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042777,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	iAPECO1_1312.APECO1_2725,iE2348C_1286.E2348C_4048,iEC042_1314.EC042_4125,iECABU_c1320.ECABU_c42230,iECED1_1282.ECED1_4428,iECIAI39_1322.ECIAI39_4342,iECNA114_1301.ECNA114_3887,iECOK1_1307.ECOK1_4187,iECP_1309.ECP_3937,iECS88_1305.ECS88_4160,iECSF_1327.ECSF_3586,iECUMN_1333.ECUMN_4268,iEcSMS35_1347.EcSMS35_4106,iLF82_1304.LF82_0192,iNRG857_1313.NRG857_18615,iUMN146_1321.UM146_18880,iUMNK88_1353.UMNK88_4550,iUTI89_1310.UTI89_C4293,ic_1306.c4666	ATP-synt_A
k59_790334_2	1042209.HK44_012900	1.33e-08	56.2	COG3312@1|root,COG3312@2|Bacteria,1N777@1224|Proteobacteria,1SD0Z@1236|Gammaproteobacteria,1YSCV@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	C	ATP synthase, subunit I	atpI	GO:0003674,GO:0003824,GO:0005215,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044769,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02116	-	-	-	-	ko00000,ko00194	3.A.2.1	-	-	ATP-synt_I
k59_1345846_1	1081644.IMCC13023_09920	1.56e-52	179.0	COG4597@1|root,COG4597@2|Bacteria	2|Bacteria	P	amino acid transport	bgtB	-	-	ko:K09970,ko:K09971	ko02010,map02010	M00232	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	BPD_transp_1
k59_344995_1	530564.Psta_3813	5.48e-26	111.0	COG0668@1|root,COG1196@1|root,COG0668@2|Bacteria,COG1196@2|Bacteria,2J2C2@203682|Planctomycetes	203682|Planctomycetes	M	Mechanosensitive ion channel	-	-	-	ko:K03442,ko:K22044	-	-	-	-	ko00000,ko02000	1.A.23.2,1.A.23.3	-	-	MS_channel
k59_1124243_1	1124780.ANNU01000043_gene345	8e-15	79.3	COG4324@1|root,COG4324@2|Bacteria,4NF0V@976|Bacteroidetes,47NVX@768503|Cytophagia	976|Bacteroidetes	I	Putative aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Aminopep
k59_178337_1	1267535.KB906767_gene20	4.09e-54	185.0	COG0162@1|root,COG0162@2|Bacteria,3Y2NC@57723|Acidobacteria,2JHYA@204432|Acidobacteriia	204432|Acidobacteriia	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
k59_956743_1	177439.DP1198	4.24e-73	231.0	COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,42NK7@68525|delta/epsilon subdivisions,2WKTV@28221|Deltaproteobacteria,2MMQF@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,ELFV_dehydrog,ELFV_dehydrog_N
k59_1679500_1	512565.AMIS_42300	2.04e-21	94.7	COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria,4D8HK@85008|Micromonosporales	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_1068087_1	1184267.A11Q_1676	2e-56	191.0	COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,42M84@68525|delta/epsilon subdivisions,2MSZP@213481|Bdellovibrionales,2WJ5V@28221|Deltaproteobacteria	213481|Bdellovibrionales	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
k59_1068088_1	742817.HMPREF9449_02474	4.64e-96	290.0	COG0205@1|root,COG0205@2|Bacteria,4NFPT@976|Bacteroidetes,2FMJ9@200643|Bacteroidia,22ZT1@171551|Porphyromonadaceae	976|Bacteroidetes	G	Phosphofructokinase	-	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
k59_1623536_1	1380394.JADL01000001_gene2992	7.64e-63	209.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TSB1@28211|Alphaproteobacteria,2JQBQ@204441|Rhodospirillales	204441|Rhodospirillales	EH	Belongs to the TPP enzyme family	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_1401616_1	103733.JNYO01000021_gene6765	2.19e-67	228.0	COG1048@1|root,COG1048@2|Bacteria,2GJD5@201174|Actinobacteria,4DY9U@85010|Pseudonocardiales	201174|Actinobacteria	C	aconitate hydratase	acnA	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0005506,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008198,GO:0009060,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0015980,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0030312,GO:0030350,GO:0032787,GO:0040007,GO:0042221,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046459,GO:0046872,GO:0046914,GO:0047456,GO:0048037,GO:0050896,GO:0051536,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:1901363	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k59_901849_1	926569.ANT_13220	2.72e-58	200.0	COG0018@1|root,COG0018@2|Bacteria,2G6DK@200795|Chloroflexi	200795|Chloroflexi	J	Arginyl-tRNA synthetase	argS	GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
k59_1238040_1	400682.PAC_15710332	9.78e-90	295.0	COG1132@1|root,KOG0055@2759|Eukaryota,39YRK@33154|Opisthokonta,3BN4Z@33208|Metazoa	33208|Metazoa	Q	atp-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,oligo_HPY
k59_847082_1	66377.JOBH01000012_gene4489	8.88e-17	85.1	COG1472@1|root,COG1472@2|Bacteria,2GJ5H@201174|Actinobacteria	201174|Actinobacteria	G	hydrolase, family 3	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	CBM_6,Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
k59_1681415_1	1502850.FG91_01009	1.96e-41	141.0	COG0251@1|root,COG0251@2|Bacteria,1RH61@1224|Proteobacteria,2UAE3@28211|Alphaproteobacteria,2K689@204457|Sphingomonadales	204457|Sphingomonadales	J	Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
k59_180166_1	693661.Arcve_0782	1.27e-26	105.0	COG2107@1|root,arCOG00654@2157|Archaea,2XWEB@28890|Euryarchaeota,245X4@183980|Archaeoglobi	183980|Archaeoglobi	H	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnD	-	-	ko:K11785	ko00130,ko01110,map00130,map01110	-	R08589	RC02330	ko00000,ko00001,ko01000	-	-	-	VitK2_biosynth
k59_180166_2	1051632.TPY_1473	6.95e-52	171.0	COG2220@1|root,COG2220@2|Bacteria,1TQR1@1239|Firmicutes,249X0@186801|Clostridia	186801|Clostridia	S	Belongs to the UPF0173 family	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2,Lactamase_B_3
k59_1570335_1	460265.Mnod_6639	1.54e-58	197.0	COG3666@1|root,COG3666@2|Bacteria,1QW5T@1224|Proteobacteria,2TWNW@28211|Alphaproteobacteria,1JTK7@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	PFAM transposase IS4 family protein	tnp*	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_1238058_1	1380347.JNII01000009_gene2022	3.63e-10	60.1	COG2318@1|root,COG2318@2|Bacteria,2II1I@201174|Actinobacteria,4ET39@85013|Frankiales	201174|Actinobacteria	S	Protein of unknown function (DUF664)	-	-	-	-	-	-	-	-	-	-	-	-	DUF664,DinB_2
k59_1292172_1	485913.Krac_10556	1.5e-57	199.0	COG4585@1|root,COG4585@2|Bacteria,2G88D@200795|Chloroflexi	200795|Chloroflexi	T	histidine kinase, dimerisation and phosphoacceptor region	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GAF_3,HATPase_c,HisKA_3
k59_681387_1	913865.DOT_4712	2.31e-25	95.9	2E9H4@1|root,333Q5@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_180181_1	404589.Anae109_1954	9.06e-77	234.0	COG1403@1|root,COG1403@2|Bacteria,1MWEQ@1224|Proteobacteria,437B2@68525|delta/epsilon subdivisions,2X2FR@28221|Deltaproteobacteria,2Z0QW@29|Myxococcales	28221|Deltaproteobacteria	L	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH_5
k59_1292189_1	1410620.SHLA_61c000240	1.14e-41	153.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,4B7AV@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	belongs to the aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_1126249_1	95619.PM1_0215950	3.24e-49	169.0	COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,1RNTY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
k59_291929_1	33876.JNXY01000013_gene4106	1.19e-09	62.4	COG4544@1|root,COG4544@2|Bacteria,2IIXE@201174|Actinobacteria,4DA6N@85008|Micromonosporales	201174|Actinobacteria	S	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division	-	GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360	-	-	-	-	-	-	-	-	-	-	-
k59_1347837_1	550540.Fbal_2167	5.33e-08	58.9	COG3764@1|root,COG3764@2|Bacteria,1N05G@1224|Proteobacteria,1SB22@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	COG3764 Sortase (surface protein transpeptidase)	-	-	-	-	-	-	-	-	-	-	-	-	Sortase
k59_1459548_1	1121015.N789_03460	8.38e-23	98.6	COG1596@1|root,COG1596@2|Bacteria,1N7GP@1224|Proteobacteria,1RQSM@1236|Gammaproteobacteria,1X7BN@135614|Xanthomonadales	135614|Xanthomonadales	M	Polysaccharide biosynthesis/export protein	-	-	-	-	-	-	-	-	-	-	-	-	Poly_export,SLBB
k59_1570375_1	1115512.EH105704_01_08470	7.38e-74	230.0	COG0408@1|root,COG0408@2|Bacteria,1MWMF@1224|Proteobacteria,1RMM8@1236|Gammaproteobacteria,3XMMV@561|Escherichia	1236|Gammaproteobacteria	H	Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX	hemF	GO:0003674,GO:0003824,GO:0004109,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0016634,GO:0018130,GO:0019438,GO:0030145,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046906,GO:0046914,GO:0046983,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	1.3.3.3	ko:K00228	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03220	RC00884	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b2436,iBWG_1329.BWG_2198,iECDH10B_1368.ECDH10B_2601,iECDH1ME8569_1439.ECDH1ME8569_2370,iETEC_1333.ETEC_2549,iEcDH1_1363.EcDH1_1225,iEcHS_1320.EcHS_A2573,iEcolC_1368.EcolC_1243,iJO1366.b2436,iJR904.b2436,iY75_1357.Y75_RS12760	Coprogen_oxidas
k59_1625418_2	339671.Asuc_1813	5.5e-18	83.2	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,1RMU2@1236|Gammaproteobacteria,1Y7RE@135625|Pasteurellales	135625|Pasteurellales	C	fumarate reductase, flavoprotein subunit	frdA	GO:0000104,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006091,GO:0006113,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016627,GO:0022900,GO:0032991,GO:0044237,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045273,GO:0045274,GO:0045283,GO:0045284,GO:0045333,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803	1.3.5.4	ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_13900_1	59538.XP_005968773.1	5.33e-11	62.8	COG0482@1|root,KOG2805@2759|Eukaryota,38BAG@33154|Opisthokonta,3BF95@33208|Metazoa,3CU33@33213|Bilateria,487JF@7711|Chordata,490P6@7742|Vertebrata,3JEYX@40674|Mammalia,4J559@91561|Cetartiodactyla	33208|Metazoa	J	mitochondrial tRNA-specific 2-thiouridylase	-	-	2.8.1.14	ko:K21027	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_Me_trans
k59_13900_2	1162668.LFE_2384	1.08e-19	85.5	COG1664@1|root,COG1664@2|Bacteria,3J1F5@40117|Nitrospirae	40117|Nitrospirae	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
k59_1570388_1	1117943.SFHH103_04113	1.33e-39	149.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4B9BA@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,TPR_8
k59_1238110_1	95619.PM1_0205680	5.11e-20	94.4	COG0665@1|root,COG0665@2|Bacteria,1MVIZ@1224|Proteobacteria	1224|Proteobacteria	E	D-Amino acid dehydrogenase	thiO	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016491,GO:0016638,GO:0016641,GO:0017144,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0036094,GO:0042364,GO:0042723,GO:0042724,GO:0043167,GO:0043168,GO:0043436,GO:0043799,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0071949,GO:0072527,GO:0072528,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	1.4.3.19,1.4.5.1	ko:K00285,ko:K03153	ko00360,ko00730,ko01100,map00360,map00730,map01100	-	R01374,R07463,R09493	RC00006,RC00025,RC01788	ko00000,ko00001,ko01000	-	-	-	DAO
k59_346890_2	1172186.KB911464_gene4877	7.25e-18	84.0	COG2141@1|root,COG2141@2|Bacteria,2GKPX@201174|Actinobacteria,2335G@1762|Mycobacteriaceae	201174|Actinobacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_681445_1	344747.PM8797T_12503	1.36e-88	276.0	COG0129@1|root,COG0129@2|Bacteria,2IWXV@203682|Planctomycetes	203682|Planctomycetes	H	Belongs to the IlvD Edd family	ilvD	GO:0003674,GO:0003824,GO:0004160,GO:0016829,GO:0016835,GO:0016836	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
k59_1069974_1	1304284.L21TH_2551	2.39e-32	125.0	COG0593@1|root,COG0593@2|Bacteria,1TPV7@1239|Firmicutes,2490S@186801|Clostridia,36DSQ@31979|Clostridiaceae	186801|Clostridia	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
k59_180235_1	381666.H16_A0037	3.55e-65	210.0	COG2175@1|root,COG2175@2|Bacteria,1MV5K@1224|Proteobacteria,2VKXH@28216|Betaproteobacteria,1K85I@119060|Burkholderiaceae	28216|Betaproteobacteria	Q	Taurine catabolism dioxygenase TauD, TfdA family	tauD	-	1.14.11.17	ko:K03119	ko00430,ko00920,map00430,map00920	-	R05320	RC01331	ko00000,ko00001,ko01000	-	-	-	TauD
k59_459017_1	1340493.JNIF01000003_gene4295	1.41e-07	55.8	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_736876_1	926550.CLDAP_31600	3.22e-55	184.0	COG1063@1|root,COG1063@2|Bacteria,2G6FN@200795|Chloroflexi	200795|Chloroflexi	E	PFAM Alcohol dehydrogenase zinc-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ADH_zinc_N
k59_681484_1	204773.HEAR2119	4.09e-53	182.0	COG0154@1|root,COG0154@2|Bacteria,1MWRI@1224|Proteobacteria,2VM0Y@28216|Betaproteobacteria,472N9@75682|Oxalobacteraceae	28216|Betaproteobacteria	J	Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
k59_1014922_1	1189612.A33Q_2982	1.53e-55	197.0	COG4447@1|root,COG4447@2|Bacteria,4NESU@976|Bacteroidetes,47U4M@768503|Cytophagia	976|Bacteroidetes	G	Sortilin, neurotensin receptor 3,	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
k59_1514811_1	400682.PAC_15725123	2.92e-38	143.0	COG1252@1|root,KOG2495@2759|Eukaryota,38G4F@33154|Opisthokonta,3BM0I@33208|Metazoa	33208|Metazoa	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.5.9	ko:K17871	-	-	-	-	ko00000,ko01000	-	-	-	Pyr_redox_2
k59_1737075_1	192952.MM_1893	2.44e-111	332.0	COG0641@1|root,arCOG00945@2157|Archaea,2Y0F7@28890|Euryarchaeota,2NAGD@224756|Methanomicrobia	224756|Methanomicrobia	K	SEC-C motif	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SEC-C,SPASM
k59_903926_1	1298880.AUEV01000002_gene1753	5.09e-28	114.0	COG1404@1|root,COG1404@2|Bacteria,2GJYH@201174|Actinobacteria	201174|Actinobacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Inhibitor_I9,P_proprotein,Peptidase_S8
k59_958844_1	1521187.JPIM01000073_gene2804	2.81e-117	354.0	COG0443@1|root,COG0443@2|Bacteria,2G5U5@200795|Chloroflexi,37538@32061|Chloroflexia	32061|Chloroflexia	O	Heat shock 70 kDa protein	-	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
k59_1403713_1	861299.J421_5847	6.87e-34	126.0	2E3HM@1|root,30MSF@2|Bacteria,1ZV6S@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_459069_2	3218.PP1S234_46V6.1	2.77e-32	125.0	COG0825@1|root,2QPRP@2759|Eukaryota,37MIP@33090|Viridiplantae,3G9IS@35493|Streptophyta	35493|Streptophyta	I	Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha	CAC3	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009526,GO:0009532,GO:0009536,GO:0009570,GO:0009941,GO:0016020,GO:0031967,GO:0031975,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464	2.1.3.15,6.4.1.2	ko:K01962	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	ACCA
k59_402988_1	644966.Tmar_1144	8.3e-59	202.0	COG1921@1|root,COG1921@2|Bacteria,1TQT8@1239|Firmicutes,2498U@186801|Clostridia,3WCCS@538999|Clostridiales incertae sedis	186801|Clostridia	J	Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis	selA	-	2.9.1.1	ko:K01042	ko00450,ko00970,map00450,map00970	-	R08219	RC01246	ko00000,ko00001,ko01000	-	-	-	Se-cys_synth_N,SelA
k59_1033692_1	720554.Clocl_1406	4.06e-26	113.0	COG1418@1|root,COG1418@2|Bacteria,1TP48@1239|Firmicutes,248G8@186801|Clostridia,3WGE5@541000|Ruminococcaceae	186801|Clostridia	D	Endoribonuclease that initiates mRNA decay	rny	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
k59_1310677_1	1173026.Glo7428_3652	1.06e-05	52.8	COG0666@1|root,COG0666@2|Bacteria,1G0E1@1117|Cyanobacteria	1117|Cyanobacteria	S	Ankyrin repeat	ank	-	-	ko:K06867	-	-	-	-	ko00000	-	-	-	Ank_2,Ank_3,Ank_4,Ank_5
k59_531303_1	459349.CLOAM0726	3.94e-73	228.0	COG0451@1|root,COG0451@2|Bacteria,2NQD6@2323|unclassified Bacteria	2|Bacteria	GM	RmlD substrate binding domain	ltd	-	4.2.1.45	ko:K01709	ko00520,map00520	-	R02426	RC00402	ko00000,ko00001,ko01000	-	-	-	Epimerase
k59_1531651_1	1038859.AXAU01000026_gene2332	1.5e-41	144.0	COG1173@1|root,COG1173@2|Bacteria,1MWMX@1224|Proteobacteria,2TRX5@28211|Alphaproteobacteria,3JRYA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
k59_1531651_2	1262915.BN574_01720	2.41e-05	44.7	COG5416@1|root,COG5416@2|Bacteria,1VK4W@1239|Firmicutes,4H67X@909932|Negativicutes	909932|Negativicutes	S	Pfam:DUF1049	-	-	-	-	-	-	-	-	-	-	-	-	LapA_dom
k59_477693_1	203119.Cthe_1840	2.51e-62	202.0	COG0031@1|root,COG0031@2|Bacteria,1TP30@1239|Firmicutes,2497G@186801|Clostridia,3WG9Z@541000|Ruminococcaceae	186801|Clostridia	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysK	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_197131_2	443218.AS9A_4549	7.15e-38	142.0	COG0025@1|root,COG0025@2|Bacteria,2GIUT@201174|Actinobacteria,234N8@1762|Mycobacteriaceae	201174|Actinobacteria	P	Sodium hydrogen exchanger	yjcE	GO:0003674,GO:0005215,GO:0005451,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0006814,GO:0006873,GO:0006885,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015079,GO:0015081,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015385,GO:0015386,GO:0015491,GO:0015672,GO:0016020,GO:0019725,GO:0022804,GO:0022821,GO:0022857,GO:0022890,GO:0030001,GO:0030003,GO:0030004,GO:0030641,GO:0034220,GO:0035725,GO:0042592,GO:0044464,GO:0046873,GO:0048878,GO:0050801,GO:0051179,GO:0051234,GO:0051453,GO:0055067,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071804,GO:0071805,GO:0071944,GO:0098655,GO:0098657,GO:0098659,GO:0098660,GO:0098662,GO:0098719,GO:0098739,GO:0098771,GO:0099516,GO:0099587,GO:1902600	-	ko:K03316	-	-	-	-	ko00000	2.A.36	-	-	Na_H_Exchanger
k59_699067_2	479433.Caci_1272	8.34e-09	59.3	COG0612@1|root,COG0612@2|Bacteria,2GJZ3@201174|Actinobacteria	201174|Actinobacteria	S	Belongs to the peptidase M16 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_30873_1	1380391.JIAS01000020_gene1434	1.77e-64	217.0	COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,2TQRQ@28211|Alphaproteobacteria,2JQSC@204441|Rhodospirillales	204441|Rhodospirillales	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parC	-	-	ko:K02621	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_977308_1	273068.TTE2092	4.17e-16	84.0	COG0739@1|root,COG0741@1|root,COG0739@2|Bacteria,COG0741@2|Bacteria,1TPK4@1239|Firmicutes,25KEP@186801|Clostridia,42I2X@68295|Thermoanaerobacterales	186801|Clostridia	M	Transglycosylase SLT domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23,SLT
k59_1143859_1	420324.KI912090_gene7165	7.65e-122	365.0	COG0514@1|root,COG0514@2|Bacteria,1MVGG@1224|Proteobacteria,2TS8B@28211|Alphaproteobacteria,1JR9X@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	TIGRFAM ATP-dependent DNA helicase, RecQ	recQ	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,Helicase_C,RQC,RecQ_Zn_bind
k59_1310693_1	269799.Gmet_0555	1.63e-64	214.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WKJX@28221|Deltaproteobacteria,43S25@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Domains REC, sigma54 interaction, HTH8	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1420719_1	324602.Caur_0806	1.03e-51	176.0	COG3185@1|root,COG3185@2|Bacteria,2G7XQ@200795|Chloroflexi,3765R@32061|Chloroflexia	32061|Chloroflexia	C	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	1.13.11.27	ko:K00457	ko00130,ko00350,ko00360,ko01100,map00130,map00350,map00360,map01100	M00044	R01372,R02521	RC00505,RC00738	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Glyoxalase
k59_1255887_1	401526.TcarDRAFT_1910	3.33e-17	85.9	COG4753@1|root,COG4963@1|root,COG4753@2|Bacteria,COG4963@2|Bacteria,1UF2S@1239|Firmicutes,4H306@909932|Negativicutes	909932|Negativicutes	KTU	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_31,Response_reg
k59_1587805_1	1121396.KB893046_gene3303	7.58e-56	190.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,42N0C@68525|delta/epsilon subdivisions,2WIUM@28221|Deltaproteobacteria,2MI28@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_922753_1	903818.KI912268_gene3024	8.01e-20	93.6	COG1132@1|root,COG1132@2|Bacteria,3Y32T@57723|Acidobacteria	57723|Acidobacteria	V	ABC transporter transmembrane	-	-	-	ko:K18889	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106.13,3.A.1.106.5	-	-	ABC_membrane,ABC_tran
k59_30894_1	1379270.AUXF01000006_gene255	1e-59	197.0	COG0304@1|root,COG0304@2|Bacteria,1ZSPM@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_1310725_1	588932.JHOF01000018_gene1311	6.98e-67	229.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,2KFKZ@204458|Caulobacterales	204458|Caulobacterales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_1143897_1	319225.Plut_0448	5.33e-14	72.8	COG0558@1|root,COG0558@2|Bacteria,1FDVM@1090|Chlorobi	1090|Chlorobi	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
k59_1143897_2	373903.Hore_11950	6.37e-05	45.1	COG1267@1|root,COG1267@2|Bacteria,1VHN4@1239|Firmicutes,24T29@186801|Clostridia,3WAXJ@53433|Halanaerobiales	186801|Clostridia	I	PFAM Phosphatidylglycerophosphatase A	-	-	3.1.3.27	ko:K01095	ko00564,ko01100,map00564,map01100	-	R02029	RC00017	ko00000,ko00001,ko01000	-	-	-	PgpA
k59_477740_1	999611.KI421504_gene424	2.41e-45	162.0	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,2TRW2@28211|Alphaproteobacteria,280GI@191028|Leisingera	28211|Alphaproteobacteria	M	Peptidase family S41	ctpA	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
k59_699121_1	83406.HDN1F_16520	1.19e-61	203.0	COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,1RNZE@1236|Gammaproteobacteria,1J4Y1@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006464,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0036211,GO:0042802,GO:0043021,GO:0043022,GO:0043170,GO:0043335,GO:0043412,GO:0044183,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0050896,GO:0051083,GO:0061077,GO:0071704,GO:0140096,GO:1901564	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
k59_531359_1	926569.ANT_04080	2.62e-69	226.0	COG0143@1|root,COG0143@2|Bacteria,2G5ZU@200795|Chloroflexi	200795|Chloroflexi	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g
k59_1087782_1	305900.GV64_20970	1.97e-40	150.0	COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,1RMXX@1236|Gammaproteobacteria,1XH8T@135619|Oceanospirillales	135619|Oceanospirillales	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
k59_863651_1	570967.JMLV01000001_gene2651	6.18e-70	236.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,2TSCN@28211|Alphaproteobacteria,2JP92@204441|Rhodospirillales	204441|Rhodospirillales	L	DNA polymerase	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_641465_1	671143.DAMO_2610	5.64e-20	88.2	COG0160@1|root,COG0160@2|Bacteria,2NNRV@2323|unclassified Bacteria	2|Bacteria	E	Aminotransferase class-III	gabT	-	2.6.1.19,2.6.1.22,2.6.1.33,2.6.1.36	ko:K03918,ko:K07250,ko:K20428	ko00250,ko00280,ko00410,ko00525,ko00640,ko00650,ko01100,ko01120,ko01130,map00250,map00280,map00410,map00525,map00640,map00650,map01100,map01120,map01130	M00027	R00457,R00908,R01648,R02773,R04188	RC00006,RC00062,RC00160,RC00781	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_641465_2	1122621.ATZA01000033_gene530	1.15e-35	134.0	COG0189@1|root,COG0189@2|Bacteria,4NJSZ@976|Bacteroidetes,1IVRS@117747|Sphingobacteriia	976|Bacteroidetes	HJ	ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1587850_1	525904.Tter_2663	8.19e-74	234.0	COG2059@1|root,COG2059@2|Bacteria,2NPUT@2323|unclassified Bacteria	2|Bacteria	P	Chromate transporter	chrA	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
k59_531369_1	926569.ANT_15110	1.21e-95	284.0	COG0745@1|root,COG0745@2|Bacteria,2G5ND@200795|Chloroflexi	200795|Chloroflexi	K	Two component transcriptional regulator, winged helix family	-	-	-	ko:K07667,ko:K07668	ko02020,ko02024,map02020,map02024	M00454,M00459	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_1200624_1	690585.JNNU01000024_gene3976	8.1e-09	60.8	COG3448@1|root,COG3448@2|Bacteria,1MXJG@1224|Proteobacteria,2U4U4@28211|Alphaproteobacteria,4BAR8@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	CBS-domain-containing membrane protein	-	-	-	ko:K07168	-	-	-	-	ko00000	-	-	-	CBS,HPP
k59_1312978_1	316067.Geob_2074	9.7e-56	177.0	COG1569@1|root,COG1569@2|Bacteria,1QSUM@1224|Proteobacteria,42WJR@68525|delta/epsilon subdivisions,2WRT9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN_3
k59_865828_1	479431.Namu_4298	1.83e-15	75.5	COG0082@1|root,COG0082@2|Bacteria,2GJJN@201174|Actinobacteria,4ES2K@85013|Frankiales	201174|Actinobacteria	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016491,GO:0016651,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2540c	Chorismate_synt
k59_865828_2	1382306.JNIM01000001_gene1219	1.01e-27	112.0	COG0436@1|root,COG0436@2|Bacteria,2G60K@200795|Chloroflexi	200795|Chloroflexi	E	Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate	dapL	-	2.6.1.83	ko:K10206	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_924999_1	876044.IMCC3088_991	2.35e-45	161.0	COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,1RMR4@1236|Gammaproteobacteria,1J5AS@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntB	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
k59_1200635_1	62928.azo2482	1.39e-10	67.0	COG0642@1|root,COG3829@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,COG3829@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,2KVVC@206389|Rhodocyclales	206389|Rhodocyclales	T	COG0642 Signal transduction histidine kinase	-	-	2.7.13.3	ko:K11527	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,Hpt,PAS_4,PAS_9,Response_reg
k59_1146120_1	671143.DAMO_1179	3.14e-123	385.0	COG0209@1|root,COG0209@2|Bacteria,2NNVF@2323|unclassified Bacteria	2|Bacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdZ	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN,TSCPD
k59_1755297_1	926569.ANT_10600	2.66e-115	343.0	COG0442@1|root,COG0442@2|Bacteria,2G636@200795|Chloroflexi	200795|Chloroflexi	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	GO:0003674,GO:0003824,GO:0004812,GO:0004827,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006433,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017101,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
k59_1643737_1	1379270.AUXF01000003_gene3691	1.47e-35	134.0	COG0524@1|root,COG0524@2|Bacteria,1ZTFD@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_88623_1	945713.IALB_0586	1.73e-18	89.7	COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria	2|Bacteria	M	membrane organization	-	-	-	ko:K03641,ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33,2.C.1.2	-	-	Bac_surface_Ag,PD40,POTRA,Peptidase_MA_2
k59_533584_1	588596.U9ULY8	5.05e-34	127.0	COG0450@1|root,KOG0852@2759|Eukaryota,38B9P@33154|Opisthokonta,3NY1W@4751|Fungi	4751|Fungi	O	to Saccharomyces cerevisiae TSA2 (YDR453C) and TSA1 (YML028W)	TSA1	GO:0000075,GO:0000077,GO:0000302,GO:0001302,GO:0003674,GO:0003824,GO:0004601,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005844,GO:0006109,GO:0006111,GO:0006139,GO:0006259,GO:0006355,GO:0006357,GO:0006457,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006979,GO:0007154,GO:0007568,GO:0007569,GO:0008150,GO:0008152,GO:0008379,GO:0009056,GO:0009605,GO:0009636,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010035,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0010675,GO:0010906,GO:0016209,GO:0016491,GO:0016684,GO:0016999,GO:0017001,GO:0017144,GO:0019207,GO:0019219,GO:0019220,GO:0019222,GO:0019725,GO:0030234,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031570,GO:0031668,GO:0032502,GO:0032991,GO:0033194,GO:0033554,GO:0034599,GO:0034614,GO:0034641,GO:0035690,GO:0036003,GO:0036091,GO:0042221,GO:0042262,GO:0042325,GO:0042493,GO:0042542,GO:0042592,GO:0042737,GO:0042743,GO:0042744,GO:0043021,GO:0043022,GO:0043170,GO:0043255,GO:0043433,GO:0043618,GO:0043619,GO:0043620,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045454,GO:0045786,GO:0045893,GO:0045935,GO:0045944,GO:0046483,GO:0046677,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048869,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051082,GO:0051090,GO:0051091,GO:0051093,GO:0051171,GO:0051173,GO:0051174,GO:0051186,GO:0051187,GO:0051252,GO:0051254,GO:0051716,GO:0051726,GO:0051920,GO:0055114,GO:0060255,GO:0061077,GO:0061687,GO:0061691,GO:0061692,GO:0062012,GO:0065007,GO:0065008,GO:0065009,GO:0070301,GO:0070887,GO:0071236,GO:0071496,GO:0071704,GO:0072593,GO:0080090,GO:0090304,GO:0090342,GO:0090344,GO:0097237,GO:0098754,GO:0098772,GO:0098869,GO:1901360,GO:1901522,GO:1901700,GO:1901701,GO:1902680,GO:1903506,GO:1903508,GO:1990748,GO:1990904,GO:2000112,GO:2001141	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	iMM904.YDR453C	1-cysPrx_C,AhpC-TSA
k59_755857_2	1122603.ATVI01000006_gene208	2.15e-18	84.3	COG3484@1|root,COG3484@2|Bacteria,1N057@1224|Proteobacteria,1RRR0@1236|Gammaproteobacteria,1X366@135614|Xanthomonadales	135614|Xanthomonadales	O	Proteasome subunit	-	-	-	ko:K07395	-	-	-	-	ko00000	-	-	-	Proteasome
k59_1643749_1	1121946.AUAX01000018_gene7007	1.28e-76	255.0	COG3292@1|root,COG3386@1|root,COG3292@2|Bacteria,COG3386@2|Bacteria,2IAXB@201174|Actinobacteria,4DBYV@85008|Micromonosporales	201174|Actinobacteria	GT	PFAM SMP-30 Gluconolaconase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_143614_1	926569.ANT_12980	5.02e-30	123.0	COG3391@1|root,COG4745@1|root,COG3391@2|Bacteria,COG4745@2|Bacteria,2G5PE@200795|Chloroflexi	200795|Chloroflexi	O	PFAM NHL repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	NHL,PMT_2
k59_979635_1	1437606.BBOH_0099	2.61e-09	56.2	COG1917@1|root,COG1917@2|Bacteria,2IFSF@201174|Actinobacteria,4D13U@85004|Bifidobacteriales	201174|Actinobacteria	S	Cupin domain	-	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD,Cupin_2
k59_979635_2	296591.Bpro_2862	4.79e-08	56.6	COG5285@1|root,COG5285@2|Bacteria,1R84J@1224|Proteobacteria	1224|Proteobacteria	Q	COG5285 Protein involved in biosynthesis of mitomycin antibiotics polyketide fumonisin	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
k59_811755_1	1095749.HMPREF1052_1657	1.01e-08	59.3	COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,1RNDC@1236|Gammaproteobacteria,1Y6YM@135625|Pasteurellales	135625|Pasteurellales	J	Tryptophanyl-tRNA synthetase	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
k59_811755_2	1280706.AUJE01000033_gene969	2.97e-23	99.8	COG0564@1|root,COG0564@2|Bacteria,1TPCM@1239|Firmicutes,4H2QQ@909932|Negativicutes	909932|Negativicutes	J	Responsible for synthesis of pseudouridine from uracil	rluD	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
k59_925047_1	379066.GAU_1731	3.1e-48	169.0	COG0015@1|root,COG0015@2|Bacteria,1ZSVW@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Adenylosuccinate lyase C-terminus	-	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
k59_1534003_1	345341.KUTG_07934	2.03e-16	81.6	COG1252@1|root,COG1252@2|Bacteria,2GJFE@201174|Actinobacteria,4DXU1@85010|Pseudonocardiales	201174|Actinobacteria	C	NADH dehydrogenase	-	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_643456_1	1379270.AUXF01000002_gene1585	2.05e-96	306.0	COG0515@1|root,COG0515@2|Bacteria,1ZUMJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
k59_199082_1	1248232.BANQ01000168_gene2840	2.38e-05	52.0	COG2304@1|root,COG4676@1|root,COG2304@2|Bacteria,COG4676@2|Bacteria,1PDQV@1224|Proteobacteria,1RPGD@1236|Gammaproteobacteria,1XYT2@135623|Vibrionales	135623|Vibrionales	S	Integrin alpha (beta-propellor repeats).	-	-	-	-	-	-	-	-	-	-	-	-	FG-GAP_2
k59_1146166_1	979556.MTES_2791	2.85e-55	177.0	COG2151@1|root,COG2151@2|Bacteria,2II4H@201174|Actinobacteria,4FNUZ@85023|Microbacteriaceae	201174|Actinobacteria	S	Iron-sulfur cluster assembly protein	paaJ	-	-	ko:K02612	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001	-	-	-	FeS_assembly_P
k59_1146166_2	287986.DV20_07395	6.28e-13	68.6	COG1018@1|root,COG3239@1|root,COG1018@2|Bacteria,COG3239@2|Bacteria,2GKGS@201174|Actinobacteria,4E9EK@85010|Pseudonocardiales	201174|Actinobacteria	C	Fatty acid desaturase	paaK	-	-	ko:K02613	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001	-	-	-	FAD_binding_6,FA_desaturase,Fer2,NAD_binding_1
k59_533616_1	518766.Rmar_1178	1.5e-42	163.0	COG3591@1|root,COG3591@2|Bacteria,4NEAK@976|Bacteroidetes,1FJT8@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	E	Peptidase S46	dpp7	GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005575,GO:0005576,GO:0005623,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008239,GO:0009056,GO:0009279,GO:0009986,GO:0009987,GO:0016020,GO:0016049,GO:0016787,GO:0017171,GO:0019538,GO:0019867,GO:0030154,GO:0030312,GO:0030313,GO:0031975,GO:0032502,GO:0033218,GO:0034641,GO:0040007,GO:0042277,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044462,GO:0044464,GO:0048468,GO:0048588,GO:0048589,GO:0048856,GO:0048869,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575	-	-	-	-	-	-	-	-	-	-	Peptidase_S46
k59_1643778_1	656519.Halsa_1544	7.21e-41	155.0	COG0539@1|root,COG0761@1|root,COG0539@2|Bacteria,COG0761@2|Bacteria,1TQ9N@1239|Firmicutes,247UK@186801|Clostridia,3WA6D@53433|Halanaerobiales	186801|Clostridia	J	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K02945,ko:K03527	ko00900,ko01100,ko01110,ko01130,ko03010,map00900,map01100,map01110,map01130,map03010	M00096,M00178	R05884,R08210	RC01137,RC01487	br01610,ko00000,ko00001,ko00002,ko01000,ko03011	-	-	-	LYTB,S1
k59_254982_1	1040982.AXAL01000001_gene2020	1.74e-53	179.0	COG1879@1|root,COG1879@2|Bacteria	2|Bacteria	G	ABC-type sugar transport system periplasmic component	-	-	-	ko:K02058,ko:K10439	ko02010,ko02030,map02010,map02030	M00212,M00221	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
k59_1367952_1	1283300.ATXB01000002_gene2659	2.37e-85	261.0	COG0482@1|root,COG0482@2|Bacteria,1QV6H@1224|Proteobacteria,1RQSV@1236|Gammaproteobacteria,1XH1D@135618|Methylococcales	135618|Methylococcales	J	Thiamine biosynthesis protein (ThiI)	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_312080_1	1229205.BUPH_05139	9.35e-08	51.6	COG2030@1|root,COG2030@2|Bacteria,1RIBV@1224|Proteobacteria,2VTGX@28216|Betaproteobacteria,1K782@119060|Burkholderiaceae	28216|Betaproteobacteria	I	PFAM MaoC domain protein dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
k59_312080_2	296591.Bpro_2524	1.59e-41	146.0	COG0824@1|root,COG2153@1|root,COG0824@2|Bacteria,COG2153@2|Bacteria,1MZ86@1224|Proteobacteria,2VMR6@28216|Betaproteobacteria,4A9NN@80864|Comamonadaceae	28216|Betaproteobacteria	S	Thioesterase superfamily protein	yjcF	-	-	-	-	-	-	-	-	-	-	-	4HBT,Acetyltransf_10
k59_755913_1	314264.ROS217_05094	9.52e-10	62.8	COG0438@1|root,COG0438@2|Bacteria,1MVKK@1224|Proteobacteria,2TUFG@28211|Alphaproteobacteria,46PI1@74030|Roseovarius	28211|Alphaproteobacteria	M	Glycosyl transferase, group 1 family protein	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
k59_422414_1	926569.ANT_05230	1.4e-99	308.0	COG0322@1|root,COG0322@2|Bacteria,2G651@200795|Chloroflexi	200795|Chloroflexi	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
k59_979689_1	1384056.N787_01660	1.61e-42	156.0	COG1129@1|root,COG1129@2|Bacteria,1QTT9@1224|Proteobacteria,1T1GD@1236|Gammaproteobacteria,1X3S2@135614|Xanthomonadales	135614|Xanthomonadales	V	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
k59_1755373_1	1430440.MGMSRv2_3763	6.09e-114	354.0	COG1061@1|root,COG4951@1|root,COG1061@2|Bacteria,COG4951@2|Bacteria,1QVE4@1224|Proteobacteria,2TUH9@28211|Alphaproteobacteria,2JW67@204441|Rhodospirillales	204441|Rhodospirillales	L	DEAD-like helicases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	ResIII
k59_701446_1	382464.ABSI01000014_gene1453	1.74e-45	166.0	COG2755@1|root,COG2755@2|Bacteria,46UYY@74201|Verrucomicrobia,2IVBQ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	GDSL-like Lipase/Acylhydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
k59_1146212_1	105559.Nwat_3131	4.74e-76	242.0	COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,1RP4V@1236|Gammaproteobacteria,1WVYR@135613|Chromatiales	135613|Chromatiales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
k59_1200723_1	861299.J421_0282	2.53e-19	92.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_480076_1	861299.J421_2200	1.35e-99	303.0	COG0673@1|root,COG0673@2|Bacteria,1ZSRB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
k59_755945_1	1197906.CAJQ02000006_gene2920	6.75e-63	196.0	COG3832@1|root,COG3832@2|Bacteria,1RD0P@1224|Proteobacteria,2U79U@28211|Alphaproteobacteria,3K0I0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
k59_979703_1	555088.DealDRAFT_1554	5.73e-35	135.0	COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,248JC@186801|Clostridia,42K9M@68298|Syntrophomonadaceae	186801|Clostridia	IQ	PFAM AMP-dependent synthetase and ligase	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C,AP_endonuc_2
k59_1423102_1	272563.CD630_35750	4.46e-14	77.0	COG0591@1|root,COG0591@2|Bacteria,1V0NB@1239|Firmicutes,24ENM@186801|Clostridia	186801|Clostridia	E	Sodium:solute symporter family	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
k59_701455_1	500640.CIT292_07603	1.59e-22	100.0	COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,1S087@1236|Gammaproteobacteria,3WZBR@544|Citrobacter	1236|Gammaproteobacteria	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
k59_1494682_1	83406.HDN1F_04400	1.49e-42	151.0	COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,1RMJA@1236|Gammaproteobacteria,1J4UD@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Belongs to the peptidase S11 family	dacA	GO:0000270,GO:0003674,GO:0003824,GO:0004175,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042493,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	iEC55989_1330.EC55989_2269,iSFV_1184.SFV_0694,iSbBS512_1146.SbBS512_E2506,iYL1228.KPN_00664	PBP5_C,Peptidase_S11
k59_158655_2	886293.Sinac_0625	1.14e-52	186.0	COG0612@1|root,COG0612@2|Bacteria,2IYKK@203682|Planctomycetes	2|Bacteria	S	PFAM Peptidase M16 inactive domain	pqqL	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_103450_1	1144307.PMI04_02558	3.8e-13	73.2	COG0457@1|root,COG3629@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,1MV0P@1224|Proteobacteria,2U2U5@28211|Alphaproteobacteria,2KCM2@204457|Sphingomonadales	204457|Sphingomonadales	K	DNA-binding transcriptional activator of the SARP family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_717278_1	1114964.L485_17130	3.97e-38	140.0	COG0526@1|root,COG0526@2|Bacteria,1RC8N@1224|Proteobacteria,2U7IW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1383193_1	671143.DAMO_1614	2.1e-95	280.0	COG0377@1|root,COG0377@2|Bacteria,2NPEF@2323|unclassified Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
k59_1547021_1	519989.ECTPHS_08963	1.34e-36	132.0	COG2878@1|root,COG2878@2|Bacteria,1NZIR@1224|Proteobacteria,1RPC4@1236|Gammaproteobacteria,1WWC5@135613|Chromatiales	135613|Chromatiales	C	Fe-S cluster	-	-	-	ko:K03616	-	-	-	-	ko00000	-	-	-	FeS,Fer4
k59_1547021_2	1379270.AUXF01000001_gene2161	4.86e-53	186.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,COG1146@2|Bacteria	2|Bacteria	C	4 iron, 4 sulfur cluster binding	nifJ	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4,Fer4_16,Fer4_6,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_940384_1	383372.Rcas_2335	1.41e-14	72.8	COG0240@1|root,COG0240@2|Bacteria,2G6HJ@200795|Chloroflexi,376MV@32061|Chloroflexia	32061|Chloroflexia	C	NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain	-	-	1.5.1.28	ko:K04940	-	-	-	-	ko00000,ko01000	-	-	-	NAD_Gly3P_dh_N,Octopine_DH
k59_940384_2	357808.RoseRS_2459	5.04e-52	181.0	COG5012@1|root,COG5012@2|Bacteria,2G66F@200795|Chloroflexi,376VS@32061|Chloroflexia	32061|Chloroflexia	S	cobalamin binding	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding
k59_717298_1	794903.OPIT5_26525	2.07e-65	217.0	COG0607@1|root,COG2897@1|root,COG0607@2|Bacteria,COG2897@2|Bacteria	2|Bacteria	P	thiosulfate sulfurtransferase activity	MA20_21580	-	-	-	-	-	-	-	-	-	-	-	Rhodanese,YceI
k59_1547025_1	35754.JNYJ01000026_gene8803	1.33e-16	79.3	COG1156@1|root,COG1156@2|Bacteria,2I44A@201174|Actinobacteria	201174|Actinobacteria	C	ATP synthase alpha/beta family, beta-barrel domain	-	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_1547025_2	711393.AYRX01000077_gene573	2.01e-65	218.0	COG1155@1|root,COG1155@2|Bacteria,2HESQ@201174|Actinobacteria	201174|Actinobacteria	C	ATPsynthase alpha/beta subunit N-term extension	-	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
k59_1104669_2	1278073.MYSTI_04701	1.75e-28	110.0	COG3088@1|root,COG3088@2|Bacteria,1MZZ5@1224|Proteobacteria,43DRS@68525|delta/epsilon subdivisions,2X8U4@28221|Deltaproteobacteria,2Z0DW@29|Myxococcales	28221|Deltaproteobacteria	P	subunit of a heme lyase	-	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	CcmH
k59_769456_1	926569.ANT_04980	4.92e-23	91.7	COG3677@1|root,COG3677@2|Bacteria,2G9MB@200795|Chloroflexi	200795|Chloroflexi	L	Putative ATPase subunit of terminase (gpP-like)	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23
k59_1658826_1	1379270.AUXF01000003_gene3673	3.77e-58	201.0	COG1132@1|root,COG1132@2|Bacteria,1ZSZC@142182|Gemmatimonadetes	142182|Gemmatimonadetes	V	ABC transporter transmembrane region	-	-	-	ko:K18890	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106.13,3.A.1.106.5	-	-	ABC_membrane,ABC_tran
k59_717327_1	713587.THITH_12015	7.84e-34	130.0	COG0247@1|root,COG0247@2|Bacteria,1NZIG@1224|Proteobacteria,1RYPW@1236|Gammaproteobacteria,1WXQI@135613|Chromatiales	135613|Chromatiales	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_17,Fer4_8
k59_495536_2	1206731.BAGB01000170_gene4463	5.42e-05	47.0	COG3427@1|root,COG3427@2|Bacteria,2GKTQ@201174|Actinobacteria,4FX9R@85025|Nocardiaceae	201174|Actinobacteria	S	Carbon monoxide dehydrogenase subunit G (CoxG)	-	-	-	ko:K09386	-	-	-	-	ko00000	-	-	-	COXG
k59_771100_1	748247.AZKH_4360	4.08e-43	151.0	COG0179@1|root,COG0179@2|Bacteria,1MV0V@1224|Proteobacteria,2VGZX@28216|Betaproteobacteria,2KXU8@206389|Rhodocyclales	206389|Rhodocyclales	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	3.7.1.2	ko:K16171	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R01364	RC00326,RC00446	ko00000,ko00001,ko00002,ko01000	-	-	-	FAA_hydrolase
k59_771100_2	1380394.JADL01000012_gene1024	3.48e-65	209.0	COG3508@1|root,COG3508@2|Bacteria,1MV9G@1224|Proteobacteria,2TRFI@28211|Alphaproteobacteria,2JPCP@204441|Rhodospirillales	204441|Rhodospirillales	Q	homogentisate 1,2-dioxygenase	-	-	1.13.11.5	ko:K00451	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R02519	RC00737	ko00000,ko00001,ko00002,ko01000	-	-	-	HgmA
k59_160688_1	926550.CLDAP_03270	1.84e-43	161.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,2G5QR@200795|Chloroflexi	200795|Chloroflexi	J	phenylalanyl-tRNA synthetase beta subunit	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
k59_884206_1	1123267.JONN01000002_gene82	3e-13	69.7	COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,2TR4H@28211|Alphaproteobacteria,2K185@204457|Sphingomonadales	204457|Sphingomonadales	E	argininosuccinate lyase	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
k59_884206_2	913865.DOT_2185	5.68e-34	128.0	COG0137@1|root,COG0137@2|Bacteria,1TP3X@1239|Firmicutes,247MF@186801|Clostridia,260N0@186807|Peptococcaceae	186801|Clostridia	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
k59_771111_1	431947.PGN_0704	2.25e-05	49.3	COG1629@1|root,COG4771@2|Bacteria,4NET0@976|Bacteroidetes,2FMGU@200643|Bacteroidia	976|Bacteroidetes	P	TonB-dependent receptor	-	-	-	ko:K16089	-	-	-	-	ko00000,ko02000	1.B.14.1,1.B.14.10	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
k59_497408_1	512565.AMIS_17520	3.4e-31	122.0	COG4447@1|root,COG4447@2|Bacteria,2GM8J@201174|Actinobacteria,4D9DS@85008|Micromonosporales	201174|Actinobacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR
k59_942192_1	1519464.HY22_04375	2.04e-57	202.0	COG5448@1|root,COG5448@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2460
k59_1660496_1	857087.Metme_0985	4.68e-52	181.0	COG3673@1|root,COG3673@2|Bacteria,1NFRW@1224|Proteobacteria,1RP20@1236|Gammaproteobacteria,1XG0U@135618|Methylococcales	135618|Methylococcales	S	Uncharacterized alpha/beta hydrolase domain (DUF2235)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2235
k59_160718_1	234267.Acid_1869	8.37e-48	166.0	COG0031@1|root,COG0031@2|Bacteria,3Y71B@57723|Acidobacteria	57723|Acidobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_771125_1	861299.J421_1876	3.15e-68	224.0	COG3386@1|root,COG3386@2|Bacteria	2|Bacteria	G	gluconolactonase activity	-	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	SGL
k59_942196_2	404380.Gbem_1055	2.16e-16	80.9	COG4962@1|root,COG4962@2|Bacteria,1R7EN@1224|Proteobacteria,42NAK@68525|delta/epsilon subdivisions,2WIYX@28221|Deltaproteobacteria,43SA4@69541|Desulfuromonadales	28221|Deltaproteobacteria	U	PFAM type II secretion system protein E	-	-	-	ko:K02283,ko:K03609	-	-	-	-	ko00000,ko02035,ko02044,ko03036,ko04812	-	-	-	CbiA,FHA,T2SSE
k59_160727_2	1382303.JPOM01000001_gene642	9.23e-09	57.0	COG0029@1|root,COG0157@1|root,COG0029@2|Bacteria,COG0157@2|Bacteria,1RBQW@1224|Proteobacteria,2TS0E@28211|Alphaproteobacteria,2KF91@204458|Caulobacterales	204458|Caulobacterales	H	PFAM fumarate reductase succinate dehydrogenase flavoprotein domain protein	nadB	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_827963_1	1394176.AWUO01000006_gene576	5.84e-15	73.9	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,4CZ24@85004|Bifidobacteriales	201174|Actinobacteria	P	E1-E2 ATPase	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	Cupredoxin_1,E1-E2_ATPase,HMA,Hydrolase,YHS
k59_160740_1	398767.Glov_1694	1.94e-13	71.6	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_160740_2	1304885.AUEY01000009_gene1951	9.84e-16	79.0	COG3829@1|root,COG3852@1|root,COG4191@1|root,COG3829@2|Bacteria,COG3852@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,2MI2B@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,dCache_1
k59_330188_1	338963.Pcar_2375	8.71e-66	207.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,42PYJ@68525|delta/epsilon subdivisions,2WKHY@28221|Deltaproteobacteria,43SDA@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_497456_2	639030.JHVA01000001_gene3457	6.25e-14	77.0	COG0354@1|root,COG0354@2|Bacteria,3Y2PI@57723|Acidobacteria,2JJ3H@204432|Acidobacteriia	204432|Acidobacteriia	S	Belongs to the GcvT family	-	-	-	ko:K06980	-	-	-	-	ko00000,ko03016	-	-	-	GCV_T,GCV_T_C
k59_1548648_1	266264.Rmet_3899	5.01e-87	267.0	COG1960@1|root,COG1960@2|Bacteria,1MVAH@1224|Proteobacteria,2VKD1@28216|Betaproteobacteria,1JZRA@119060|Burkholderiaceae	28216|Betaproteobacteria	C	acyl-CoA dehydrogenase	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_719266_1	402881.Plav_3169	5.4e-84	263.0	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,2TRWB@28211|Alphaproteobacteria,1JNFT@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	2.6.1.85,4.1.3.27	ko:K01657,ko:K01665	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716	RC00010,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
k59_1385691_1	1429851.X548_06615	4.42e-42	154.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,1RMI7@1236|Gammaproteobacteria,1X38S@135614|Xanthomonadales	135614|Xanthomonadales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K18298,ko:K19586	-	M00641,M00767	-	-	ko00000,ko00002,ko01504,ko02000	2.A.6.2.47,8.A.1	-	-	Biotin_lipoyl_2,HlyD_D23
k59_1772232_1	251221.35211041	4.31e-50	175.0	COG0492@1|root,COG3437@1|root,COG0492@2|Bacteria,COG3437@2|Bacteria,1FZX5@1117|Cyanobacteria	1117|Cyanobacteria	KOT	PFAM Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Response_reg
k59_1216639_1	234267.Acid_2094	7.69e-69	229.0	COG3534@1|root,COG3534@2|Bacteria,3Y2MY@57723|Acidobacteria	57723|Acidobacteria	G	alpha-L-arabinofuranosidase	-	-	3.2.1.55	ko:K01209	ko00520,map00520	-	R01762	-	ko00000,ko00001,ko01000	-	GH51	-	Alpha-L-AF_C
k59_1497228_2	266779.Meso_1067	2.54e-22	101.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,43I48@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
k59_269853_1	189753.AXAS01000034_gene2706	7.66e-93	298.0	COG0318@1|root,COG0318@2|Bacteria,1MUMC@1224|Proteobacteria,2TR96@28211|Alphaproteobacteria,3JR8T@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	6.2.1.48	ko:K02182	-	-	-	-	ko00000,ko01000	-	-	-	AMP-binding,AMP-binding_C
k59_1439734_1	370438.PTH_1010	1.61e-10	67.0	COG1484@1|root,COG1484@2|Bacteria,1TPKM@1239|Firmicutes,2483D@186801|Clostridia,2616T@186807|Peptococcaceae	186801|Clostridia	L	DNA replication protein	-	-	-	ko:K02315	-	-	-	-	ko00000,ko03032	-	-	-	IstB_IS21
k59_942299_1	1303518.CCALI_00518	1.25e-77	249.0	COG0056@1|root,COG0056@2|Bacteria	2|Bacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0040007,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	iIT341.HP1134,iSB619.SA_RS10975,iSbBS512_1146.SbBS512_E4187	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
k59_1385719_1	1123279.ATUS01000001_gene2161	6.98e-24	103.0	COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,1RQJ9@1236|Gammaproteobacteria,1J5UN@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
k59_1548706_1	477641.MODMU_1524	1.74e-49	175.0	COG0659@1|root,COG0659@2|Bacteria,2GJCB@201174|Actinobacteria	201174|Actinobacteria	P	Sulfate transporter	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
k59_160826_1	1331060.RLDS_16440	7.93e-32	124.0	COG3046@1|root,COG3046@2|Bacteria,1MUHX@1224|Proteobacteria,2TQP6@28211|Alphaproteobacteria,2K23F@204457|Sphingomonadales	204457|Sphingomonadales	S	Deoxyribodipyrimidine photo-lyase	-	-	-	ko:K06876	-	-	-	-	ko00000	-	-	-	DPRP
k59_160826_2	671143.DAMO_2352	1.37e-10	60.8	COG0451@1|root,COG0451@2|Bacteria	2|Bacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	yeeZ	-	1.5.5.1	ko:K00311	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase,NAD_binding_10,RmlD_sub_bind
k59_269877_1	697282.Mettu_4406	1.25e-117	357.0	COG2801@1|root,COG2801@2|Bacteria,1MWVQ@1224|Proteobacteria,1RN12@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_28,HTH_32,rve
k59_160843_1	551789.ATVJ01000001_gene1523	1.68e-53	174.0	COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,2TR4J@28211|Alphaproteobacteria,43WY8@69657|Hyphomonadaceae	28211|Alphaproteobacteria	C	Electron transfer flavoprotein	etfB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0022900,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0055114	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
k59_1606666_1	1379270.AUXF01000004_gene2952	3.89e-71	237.0	COG0209@1|root,COG0209@2|Bacteria,1ZSU9@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC,Ribonuc_red_lgN
k59_48772_1	1229780.BN381_410004	8.84e-53	181.0	COG1222@1|root,COG1222@2|Bacteria,2GMR1@201174|Actinobacteria,3UX32@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	O	Proteasomal ATPase OB/ID domain	arc	GO:0000302,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0010499,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0019941,GO:0022623,GO:0022624,GO:0030163,GO:0030312,GO:0032991,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042802,GO:0043170,GO:0043335,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0044877,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070628,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097366,GO:0140030,GO:0140035,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170,GO:1902494,GO:1905368,GO:1905369	-	ko:K13527	ko03050,map03050	M00342	-	-	ko00000,ko00001,ko00002,ko03051	-	-	-	AAA,Prot_ATP_ID_OB
k59_1331382_1	459495.SPLC1_S101860	2.04e-23	99.4	COG0404@1|root,COG0404@2|Bacteria,1G0GR@1117|Cyanobacteria,1H70I@1150|Oscillatoriales	1117|Cyanobacteria	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
k59_1331382_2	357809.Cphy_1481	4.53e-09	58.5	COG0521@1|root,COG2258@1|root,COG0521@2|Bacteria,COG2258@2|Bacteria,1V3XM@1239|Firmicutes,24HG2@186801|Clostridia,21Z3U@1506553|Lachnoclostridium	186801|Clostridia	H	Molybdenum cofactor synthesis domain protein	mog	-	-	-	-	-	-	-	-	-	-	-	MOSC,MoCF_biosynth
k59_1772331_1	1203605.HMPREF1531_00357	1.11e-37	135.0	COG0745@1|root,COG0745@2|Bacteria,2GKFS@201174|Actinobacteria,4DNN6@85009|Propionibacteriales	201174|Actinobacteria	T	Transcriptional regulatory protein, C terminal	regX3	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009405,GO:0009889,GO:0010468,GO:0010556,GO:0010565,GO:0019216,GO:0019217,GO:0019219,GO:0019220,GO:0019222,GO:0031323,GO:0031326,GO:0044419,GO:0048583,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051252,GO:0051704,GO:0060255,GO:0062012,GO:0065007,GO:0080090,GO:0080134,GO:0097159,GO:1901363,GO:1902882,GO:1903506,GO:2000112,GO:2001141	-	ko:K07776	ko02020,map02020	M00443	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_497590_1	379066.GAU_2347	6.9e-74	236.0	COG0541@1|root,COG0541@2|Bacteria,1ZSPG@142182|Gemmatimonadetes	142182|Gemmatimonadetes	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
k59_1052279_1	479434.Sthe_0521	1.85e-12	70.9	COG2064@1|root,COG2064@2|Bacteria,2G6CF@200795|Chloroflexi,27XSY@189775|Thermomicrobia	189775|Thermomicrobia	NU	Type II secretion system (T2SS), protein F	-	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
k59_1548767_1	390874.Tpet_1383	4.22e-31	122.0	COG0075@1|root,COG0075@2|Bacteria,2GCGI@200918|Thermotogae	200918|Thermotogae	E	PFAM aminotransferase class V	-	GO:0001505,GO:0003674,GO:0003824,GO:0004760,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006807,GO:0008150,GO:0008152,GO:0008453,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0019265,GO:0019752,GO:0042133,GO:0042136,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	-	-	-	-	-	-	-	-	-	-	Aminotran_5
k59_438782_1	1123371.ATXH01000013_gene1536	1e-83	264.0	COG0465@1|root,COG0465@2|Bacteria,2GHGM@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_497619_1	1380355.JNIJ01000008_gene1908	4.21e-52	174.0	COG2084@1|root,COG2084@2|Bacteria,1R889@1224|Proteobacteria,2TUEY@28211|Alphaproteobacteria,3JXK9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_11,NAD_binding_2
k59_65652_1	443152.MDG893_09035	1.28e-50	173.0	COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,1RMF9@1236|Gammaproteobacteria,464W8@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	COG3547 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_121068_2	1038858.AXBA01000058_gene4340	3.87e-59	191.0	COG1116@1|root,COG1116@2|Bacteria,1MUYG@1224|Proteobacteria,2TVQX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	ABC transporter	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
k59_900172_1	1211115.ALIQ01000139_gene1307	2.41e-39	141.0	COG0834@1|root,COG0834@2|Bacteria,1MXIA@1224|Proteobacteria,2VETI@28211|Alphaproteobacteria,3NAED@45404|Beijerinckiaceae	28211|Alphaproteobacteria	ET	Bacterial periplasmic substrate-binding proteins	MA20_22110	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
k59_900172_2	1122132.AQYH01000004_gene1697	1.22e-10	62.0	COG1384@1|root,COG1384@2|Bacteria,1MV32@1224|Proteobacteria,2TQYH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04566	ko00970,map00970	M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1f
k59_10338_1	1521187.JPIM01000017_gene318	1.71e-112	336.0	COG1158@1|root,COG1158@2|Bacteria,2G5UQ@200795|Chloroflexi,37547@32061|Chloroflexia	32061|Chloroflexia	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
k59_1234417_1	234267.Acid_3462	2.19e-29	120.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	DLH
k59_65668_1	479431.Namu_1071	7.99e-15	74.7	COG0803@1|root,COG0803@2|Bacteria,2GM1K@201174|Actinobacteria,4ET8X@85013|Frankiales	201174|Actinobacteria	P	Belongs to the bacterial solute-binding protein 9 family	mntC	-	-	ko:K02077,ko:K09815,ko:K09818	ko02010,map02010	M00242,M00243,M00244	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15,3.A.1.15.3,3.A.1.15.5	-	-	ZnuA
k59_65668_2	465515.Mlut_07780	9.86e-31	117.0	COG1108@1|root,COG1108@2|Bacteria,2GJ7H@201174|Actinobacteria,1W8TI@1268|Micrococcaceae	201174|Actinobacteria	P	ABC 3 transport family	mntB	-	-	ko:K02075,ko:K09819	-	M00243,M00244	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ABC-3
k59_1122623_1	237368.SCABRO_03209	6.59e-137	421.0	COG0243@1|root,COG1104@1|root,COG0243@2|Bacteria,COG1104@2|Bacteria,2J1TP@203682|Planctomycetes	203682|Planctomycetes	CE	Molybdopterin oxidoreductase Fe4S4 domain	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5,Molybdopterin,Molydop_binding
k59_1623788_2	110663.KI911558_gene2046	1.47e-16	79.3	COG0527@1|root,COG0527@2|Bacteria,1G095@1117|Cyanobacteria,1GYD7@1129|Synechococcus	1117|Cyanobacteria	E	Aspartate kinase	lysC	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	iJN678.lysC	AA_kinase,ACT,ACT_7
k59_1179577_1	637905.SVI_3754	1.21e-54	194.0	COG1524@1|root,COG1524@2|Bacteria,1NRIA@1224|Proteobacteria,1SJN3@1236|Gammaproteobacteria,2Q9BQ@267890|Shewanellaceae	1236|Gammaproteobacteria	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
k59_122871_1	930171.Asphe3_27250	1.98e-27	114.0	COG2197@1|root,COG2197@2|Bacteria,2GKXJ@201174|Actinobacteria	201174|Actinobacteria	K	PFAM regulatory protein LuxR	-	-	-	-	-	-	-	-	-	-	-	-	GerE
k59_1401883_1	1382306.JNIM01000001_gene2907	2.19e-83	275.0	COG0653@1|root,COG0653@2|Bacteria,2G603@200795|Chloroflexi	200795|Chloroflexi	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_623279_1	1448860.BBJO01000014_gene1291	3.71e-35	131.0	COG1024@1|root,arCOG00239@2157|Archaea,2XTF0@28890|Euryarchaeota,23SMM@183963|Halobacteria	183963|Halobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
k59_512315_1	1121335.Clst_1392	6.01e-09	56.2	COG0745@1|root,COG0745@2|Bacteria,1TS81@1239|Firmicutes,248XH@186801|Clostridia,3WIJY@541000|Ruminococcaceae	186801|Clostridia	K	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	arlR	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
k59_845558_2	1089551.KE386572_gene2974	1.54e-58	188.0	COG1235@1|root,COG1235@2|Bacteria,1NW4Z@1224|Proteobacteria,2U14Z@28211|Alphaproteobacteria,4BQFW@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
k59_178611_3	96561.Dole_2293	4.7e-29	112.0	COG3527@1|root,COG3527@2|Bacteria,1MWDZ@1224|Proteobacteria,42R9C@68525|delta/epsilon subdivisions,2WN1P@28221|Deltaproteobacteria,2MJJP@213118|Desulfobacterales	28221|Deltaproteobacteria	Q	PFAM alpha-acetolactate decarboxylase	-	-	4.1.1.5	ko:K01575	ko00650,ko00660,map00650,map00660	-	R02948	RC00812	ko00000,ko00001,ko01000	-	-	-	AAL_decarboxy
k59_122888_1	1394178.AWOO02000040_gene8590	1.71e-22	93.6	COG0310@1|root,COG0310@2|Bacteria,2GK2U@201174|Actinobacteria,4EH5Z@85012|Streptosporangiales	201174|Actinobacteria	P	Cobalt uptake substrate-specific transmembrane region	cbiM	-	-	ko:K02007	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiM,PDGLE
k59_122888_2	1254432.SCE1572_00290	3.09e-05	46.6	COG0517@1|root,COG0517@2|Bacteria,1QZT1@1224|Proteobacteria,43CN4@68525|delta/epsilon subdivisions,2X7VC@28221|Deltaproteobacteria,2Z3IG@29|Myxococcales	28221|Deltaproteobacteria	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_345298_1	1120950.KB892767_gene5175	0.000385	45.1	COG0154@1|root,COG0154@2|Bacteria,2GJK5@201174|Actinobacteria,4DN5B@85009|Propionibacteriales	201174|Actinobacteria	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	-	-	3.5.1.4,6.3.5.6,6.3.5.7	ko:K01426,ko:K02433	ko00330,ko00360,ko00380,ko00627,ko00643,ko00970,ko01100,ko01120,map00330,map00360,map00380,map00627,map00643,map00970,map01100,map01120	-	R02540,R03096,R03180,R03905,R03909,R04212,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
k59_345298_2	1123072.AUDH01000029_gene1065	4.24e-11	59.7	COG3502@1|root,COG3502@2|Bacteria,1MZEQ@1224|Proteobacteria,2UBR3@28211|Alphaproteobacteria,2JT8Z@204441|Rhodospirillales	204441|Rhodospirillales	S	Protein of unknown function (DUF952)	-	-	-	-	-	-	-	-	-	-	-	-	DUF952
k59_1068361_1	555079.Toce_1809	1.12e-40	146.0	COG1940@1|root,COG1940@2|Bacteria,1TPKW@1239|Firmicutes,248U9@186801|Clostridia,42FIY@68295|Thermoanaerobacterales	186801|Clostridia	G	PFAM ROK family protein	glcK	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS10220	ROK
k59_1013144_1	765913.ThidrDRAFT_3254	2.89e-65	219.0	COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,1RNA5@1236|Gammaproteobacteria,1WWMA@135613|Chromatiales	135613|Chromatiales	P	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity	katG	-	1.11.1.21	ko:K03782	ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110	-	R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906	RC00034,RC00213,RC00767,RC02141	ko00000,ko00001,ko01000	-	-	-	peroxidase
k59_1513082_1	395494.Galf_2722	1.73e-43	146.0	28WAT@1|root,2ZIB9@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1513082_2	909663.KI867150_gene4	7.19e-09	56.6	COG3462@1|root,COG3462@2|Bacteria,1Q55M@1224|Proteobacteria,42WZ8@68525|delta/epsilon subdivisions,2WSP8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Short C-terminal domain	-	-	-	ko:K08982	-	-	-	-	ko00000	-	-	-	SHOCT
k59_401269_1	98439.AJLL01000023_gene758	2.59e-72	231.0	COG0598@1|root,COG0598@2|Bacteria,1G1AG@1117|Cyanobacteria,1JJMP@1189|Stigonemataceae	1117|Cyanobacteria	P	CorA-like Mg2+ transporter protein	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
k59_679622_1	426117.M446_1683	1.39e-41	152.0	COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,2TUW3@28211|Alphaproteobacteria,1JRTP@119045|Methylobacteriaceae	28211|Alphaproteobacteria	I	PFAM phospholipase D Transphosphatidylase	cls	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2,PLDc_N
k59_679624_1	1121087.AUCK01000001_gene2979	4.67e-59	201.0	COG0133@1|root,COG0133@2|Bacteria,1TPI3@1239|Firmicutes,4H9WC@91061|Bacilli,1ZCBT@1386|Bacillus	91061|Bacilli	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.20,5.3.1.24	ko:K01696,ko:K01817	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722,R03509	RC00209,RC00210,RC00700,RC00701,RC00945,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU22640	PALP
k59_67580_2	1144310.PMI07_001609	4.72e-47	162.0	COG1402@1|root,COG1402@2|Bacteria,1R9VU@1224|Proteobacteria,2U6WG@28211|Alphaproteobacteria,4B847@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Creatinine amidohydrolase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
k59_902147_1	1048834.TC41_0173	1.21e-47	166.0	COG0208@1|root,COG0208@2|Bacteria,1UYGN@1239|Firmicutes,4HDT8@91061|Bacilli,2799R@186823|Alicyclobacillaceae	91061|Bacilli	F	Ribonucleotide reductase, small chain	-	-	1.17.4.1	ko:K00526	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_sm
k59_122921_2	1064537.AGSO01000009_gene2014	0.000327	42.7	COG3211@1|root,COG3211@2|Bacteria,2GM1T@201174|Actinobacteria,4FC1J@85020|Dermabacteraceae	201174|Actinobacteria	O	Bacterial protein of unknown function (DUF839)	-	-	-	ko:K07093	-	-	-	-	ko00000	-	-	-	DUF839
k59_122931_1	1122621.ATZA01000018_gene3886	3.12e-26	113.0	COG1331@1|root,COG1331@2|Bacteria,4NFE2@976|Bacteroidetes,1IQ72@117747|Sphingobacteriia	976|Bacteroidetes	O	COG1331 Highly conserved protein containing a thioredoxin domain	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
k59_1735381_1	258594.RPA2903	8.07e-15	72.4	COG1974@1|root,COG1974@2|Bacteria,1MW80@1224|Proteobacteria,2TT7W@28211|Alphaproteobacteria,3JS89@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031668,GO:0032991,GO:0032993,GO:0033554,GO:0043565,GO:0044212,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
k59_1013202_1	1123508.JH636440_gene2090	1.43e-13	70.5	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,2IXH6@203682|Planctomycetes	203682|Planctomycetes	C	Pyruvate ferredoxin oxidoreductase and related	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
k59_1013202_2	344747.PM8797T_13378	1.45e-53	177.0	COG1013@1|root,COG1013@2|Bacteria,2IY6Z@203682|Planctomycetes	203682|Planctomycetes	C	COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
k59_1236473_1	33876.JNXY01000036_gene614	1.58e-37	139.0	COG1386@1|root,COG1386@2|Bacteria,2GISY@201174|Actinobacteria,4DA0T@85008|Micromonosporales	201174|Actinobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
k59_512404_1	670307.HYPDE_36603	3.42e-62	207.0	COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,2TRMX@28211|Alphaproteobacteria,3N80X@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Peptidase M16 inactive domain	MA20_05660	-	-	ko:K07263,ko:K07623	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_1513145_1	1298593.TOL_0044	7.58e-16	77.4	COG4221@1|root,COG4221@2|Bacteria,1QVS5@1224|Proteobacteria,1T2IN@1236|Gammaproteobacteria,1XJRH@135619|Oceanospirillales	135619|Oceanospirillales	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_1513145_2	1234364.AMSF01000048_gene2030	9e-24	99.0	COG1960@1|root,COG1960@2|Bacteria,1MU2V@1224|Proteobacteria,1RNJH@1236|Gammaproteobacteria,1X4KZ@135614|Xanthomonadales	135614|Xanthomonadales	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_345367_1	331869.BAL199_16718	2.38e-87	270.0	COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,2TSZN@28211|Alphaproteobacteria,4BPHX@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	NAD(P) transhydrogenase, alpha subunit	pntAA	GO:0000166,GO:0003674,GO:0003824,GO:0003957,GO:0005215,GO:0005488,GO:0005515,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006740,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0008746,GO:0008750,GO:0009117,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015672,GO:0016491,GO:0016651,GO:0016652,GO:0019362,GO:0019637,GO:0022857,GO:0022890,GO:0034220,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046496,GO:0046983,GO:0048037,GO:0050662,GO:0051179,GO:0051186,GO:0051234,GO:0051287,GO:0055085,GO:0055086,GO:0055114,GO:0070403,GO:0070404,GO:0071704,GO:0072524,GO:0097159,GO:0098655,GO:0098660,GO:0098662,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1902600	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
k59_234721_1	379066.GAU_2853	1.53e-74	233.0	COG0506@1|root,COG0506@2|Bacteria,1ZT6A@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Proline dehydrogenase	-	-	-	ko:K00318	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	-	R10507	RC00083	ko00000,ko00001,ko01000	-	-	-	Pro_dh
k59_1679883_1	1449048.JQKU01000026_gene3767	8.21e-42	152.0	COG0277@1|root,COG0277@2|Bacteria,2GKQR@201174|Actinobacteria,2338V@1762|Mycobacteriaceae	201174|Actinobacteria	C	FAD linked oxidase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_4
k59_1013240_1	1056816.JAFQ01000004_gene2831	3.78e-58	207.0	COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,4FU2Y@85025|Nocardiaceae	201174|Actinobacteria	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	GO:0000731,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0018130,GO:0019438,GO:0019985,GO:0030312,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042276,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:1901360,GO:1901362,GO:1901576	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_1513169_1	933262.AXAM01000031_gene3014	1.91e-10	62.4	COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,42N4X@68525|delta/epsilon subdivisions,2WIPR@28221|Deltaproteobacteria,2MI69@213118|Desulfobacterales	28221|Deltaproteobacteria	D	DNA segregation ATPase, FtsK SpoIIIE family	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
k59_1513169_2	671143.DAMO_2623	2.81e-28	116.0	COG0595@1|root,COG0595@2|Bacteria,2NNMI@2323|unclassified Bacteria	2|Bacteria	S	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay	rnj	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004527,GO:0004532,GO:0004534,GO:0004540,GO:0005488,GO:0005515,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008409,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042802,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0090503,GO:0140098,GO:1901360	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,Lactamase_B_2,RMMBL
k59_957164_1	1379698.RBG1_1C00001G1604	6.61e-87	286.0	COG0086@1|root,COG0086@2|Bacteria,2NNPR@2323|unclassified Bacteria	2|Bacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_1068468_2	266117.Rxyl_0317	4.33e-40	147.0	COG1523@1|root,COG1523@2|Bacteria,2GJ00@201174|Actinobacteria,4CPMY@84995|Rubrobacteria	84995|Rubrobacteria	G	Carbohydrate-binding module 48 (Isoamylase N-terminal domain)	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
k59_623417_1	1521187.JPIM01000044_gene3295	1.65e-71	238.0	COG0209@1|root,COG0209@2|Bacteria,2G5PW@200795|Chloroflexi,37772@32061|Chloroflexia	32061|Chloroflexia	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC,Ribonuc_red_lgN
k59_1458022_1	643562.Daes_2340	2.74e-47	164.0	COG2233@1|root,COG2233@2|Bacteria,1MUN9@1224|Proteobacteria,42M4U@68525|delta/epsilon subdivisions,2WJJI@28221|Deltaproteobacteria,2M96A@213115|Desulfovibrionales	28221|Deltaproteobacteria	F	PFAM Xanthine uracil vitamin C permease	uraA	-	-	ko:K02824	-	-	-	-	ko00000,ko02000	2.A.40.1.1,2.A.40.1.2	-	-	Xan_ur_permease
k59_957183_1	671143.DAMO_2217	3.94e-37	134.0	COG2854@1|root,COG2854@2|Bacteria	2|Bacteria	Q	intermembrane phospholipid transfer	-	-	-	ko:K07323	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	MlaC
k59_845708_2	1117108.PAALTS15_00035	3.73e-32	120.0	COG3440@1|root,COG3440@2|Bacteria,1U1U1@1239|Firmicutes,4IBAG@91061|Bacilli,273YE@186822|Paenibacillaceae	91061|Bacilli	L	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1290752_2	1123037.AUDE01000006_gene1211	9.96e-21	90.9	COG3191@1|root,COG3191@2|Bacteria,4NGDT@976|Bacteroidetes,1HZRM@117743|Flavobacteriia	976|Bacteroidetes	EQ	Peptidase family S58	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S58
k59_623437_1	867845.KI911784_gene835	1.09e-61	199.0	COG2120@1|root,COG2120@2|Bacteria,2G6W3@200795|Chloroflexi,375I3@32061|Chloroflexia	32061|Chloroflexia	S	PFAM LmbE family protein	-	-	3.5.1.115	ko:K18455	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
k59_1679946_1	706587.Desti_4318	2.47e-14	77.8	COG2202@1|root,COG3829@1|root,COG2202@2|Bacteria,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42MFH@68525|delta/epsilon subdivisions,2WIRW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	KT	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS,GAF_2,HTH_8,PAS,PAS_3,PAS_4,PAS_8,Response_reg,Sigma54_activat
k59_178787_1	335541.Swol_0021	6.28e-50	175.0	COG0863@1|root,COG0863@2|Bacteria,1VC9K@1239|Firmicutes	1239|Firmicutes	L	Belongs to the N(4) N(6)-methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	N6_N4_Mtase,ParBc
k59_12422_1	309801.trd_0273	3.38e-06	54.3	COG0577@1|root,COG0577@2|Bacteria,2G6CK@200795|Chloroflexi,27Z42@189775|Thermomicrobia	189775|Thermomicrobia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
k59_1568982_2	649638.Trad_1577	2.57e-43	149.0	COG1403@1|root,COG1403@2|Bacteria,1WICD@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	L	PFAM HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH_5
k59_1179788_1	443144.GM21_3803	1.17e-28	113.0	COG2890@1|root,COG2890@2|Bacteria,1MXCQ@1224|Proteobacteria,42PKA@68525|delta/epsilon subdivisions,2WNH0@28221|Deltaproteobacteria,43TP7@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_31
k59_1179788_2	1242864.D187_001757	5.72e-07	50.8	COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,42MJT@68525|delta/epsilon subdivisions,2WJ7W@28221|Deltaproteobacteria,2YUNU@29|Myxococcales	28221|Deltaproteobacteria	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
k59_123059_2	246195.DNO_0442	4.39e-14	75.1	COG3033@1|root,COG3033@2|Bacteria,1NG5U@1224|Proteobacteria,1RS6E@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Belongs to the beta-eliminating lyase family	tpl	-	4.1.99.2	ko:K01668	ko00350,map00350	-	R00728	RC00355,RC00364	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
k59_1623996_1	511062.GU3_10535	6.56e-15	78.6	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1MW7X@1224|Proteobacteria,1RRF4@1236|Gammaproteobacteria,1Y3VF@135624|Aeromonadales	135624|Aeromonadales	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_23,HTH_32,HTH_33
k59_1623996_2	203124.Tery_4975	3.76e-12	68.9	COG3415@1|root,COG3415@2|Bacteria,1G0GB@1117|Cyanobacteria,1H89N@1150|Oscillatoriales	1117|Cyanobacteria	L	Winged helix-turn helix	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_23,HTH_32,HTH_33
k59_1568992_1	439375.Oant_0704	6.46e-17	80.9	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2TQKF@28211|Alphaproteobacteria,1J3G2@118882|Brucellaceae	28211|Alphaproteobacteria	L	Integrase core domain	istA	-	-	-	-	-	-	-	-	-	-	-	rve
k59_1568992_2	1502851.FG93_00150	1.72e-13	69.3	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TSGZ@28211|Alphaproteobacteria,3JUDN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	IS116 IS110 IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_679826_1	1217718.ALOU01000093_gene1742	7.49e-29	113.0	COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,2VH1Q@28216|Betaproteobacteria,1K10Z@119060|Burkholderiaceae	28216|Betaproteobacteria	C	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_679826_2	1095769.CAHF01000013_gene3185	6.61e-38	134.0	COG2220@1|root,COG2220@2|Bacteria,1PH47@1224|Proteobacteria,2WAZ6@28216|Betaproteobacteria,4786C@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_696245_1	935557.ATYB01000009_gene734	3.27e-31	126.0	COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,4BBZJ@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_7,PAS_9
k59_1419104_2	1188256.BASI01000005_gene1649	1.19e-24	103.0	COG0609@1|root,COG0609@2|Bacteria,1MV9W@1224|Proteobacteria,2TR9A@28211|Alphaproteobacteria,3FCN8@34008|Rhodovulum	28211|Alphaproteobacteria	U	FecCD transport family	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
k59_1530348_1	1267533.KB906736_gene1246	2.97e-15	84.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria,2JM7T@204432|Acidobacteriia	204432|Acidobacteriia	KLTU	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
k59_1254352_1	272942.RCAP_rcc01099	2.37e-13	66.2	COG3293@1|root,COG3293@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_2,DUF4096
k59_1254352_2	1530186.JQEY01000029_gene1894	1.01e-100	295.0	COG3335@1|root,COG3335@2|Bacteria,1P76X@1224|Proteobacteria,2U16U@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	ko:K07494	-	-	-	-	ko00000	-	-	-	DDE_3
k59_1254352_3	1381123.AYOD01000010_gene348	4.79e-46	153.0	COG3415@1|root,COG3415@2|Bacteria,1RJ69@1224|Proteobacteria,2UB2N@28211|Alphaproteobacteria,43KYZ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	L	Homeodomain-like domain	-	-	-	ko:K07499	-	-	-	-	ko00000	-	-	-	HTH_23,HTH_32,HTH_Tnp_IS630,PAX
k59_1197220_1	877455.Metbo_0513	1.24e-16	84.7	COG0730@1|root,arCOG02050@2157|Archaea,2XXQV@28890|Euryarchaeota,23PE9@183925|Methanobacteria	183925|Methanobacteria	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
k59_584697_1	1123405.AUMM01000035_gene1744	5.16e-61	205.0	COG2986@1|root,COG2986@2|Bacteria,1TPCW@1239|Firmicutes,4H9YS@91061|Bacilli,26PKU@186821|Sporolactobacillaceae	91061|Bacilli	E	Aromatic amino acid lyase	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU39350	Lyase_aromatic
k59_530050_2	909613.UO65_5149	9.75e-27	105.0	COG4122@1|root,COG4122@2|Bacteria,2GP7A@201174|Actinobacteria,4E2Z2@85010|Pseudonocardiales	201174|Actinobacteria	S	PFAM O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_3
k59_584700_1	97137.C821_00806	1.97e-32	127.0	COG1160@1|root,COG1160@2|Bacteria,1TPNM@1239|Firmicutes,4HAJ6@91061|Bacilli,3F4V0@33958|Lactobacillaceae	91061|Bacilli	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
k59_752142_1	748247.AZKH_1022	7.55e-108	321.0	COG0722@1|root,COG0722@2|Bacteria,1MU5Q@1224|Proteobacteria,2VH4W@28216|Betaproteobacteria,2KU9M@206389|Rhodocyclales	206389|Rhodocyclales	E	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)	aroG	-	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
k59_308062_1	1090320.KB900606_gene58	2.68e-91	275.0	COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,2K2F6@204457|Sphingomonadales	204457|Sphingomonadales	L	COG2801 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve,rve_3
k59_1419150_1	1122134.KB893650_gene443	5.94e-22	96.3	COG3137@1|root,COG3137@2|Bacteria,1MWI4@1224|Proteobacteria,1RN4J@1236|Gammaproteobacteria,1XM72@135619|Oceanospirillales	135619|Oceanospirillales	M	Salt-induced outer membrane protein	ydiY	-	-	ko:K07283	-	-	-	-	ko00000	-	-	-	DUF481
k59_530075_1	1069080.KB913028_gene1442	1.17e-38	142.0	COG1418@1|root,COG1418@2|Bacteria,1TP48@1239|Firmicutes,4H2T2@909932|Negativicutes	909932|Negativicutes	S	Endoribonuclease that initiates mRNA decay	rny	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
k59_530075_2	984262.SGRA_2361	1.32e-20	87.4	COG0491@1|root,COG0491@2|Bacteria,4NE2Y@976|Bacteroidetes,1J079@117747|Sphingobacteriia	976|Bacteroidetes	P	beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_807869_1	107636.JQNK01000009_gene3513	4.33e-58	195.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2TRXG@28211|Alphaproteobacteria,370BU@31993|Methylocystaceae	28211|Alphaproteobacteria	L	Transposase DDE domain	-	-	-	ko:K07487	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_1309046_1	931627.MycrhDRAFT_2964	1.91e-17	86.3	28JDP@1|root,2Z97Z@2|Bacteria,2I9EC@201174|Actinobacteria,237NJ@1762|Mycobacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1640596_1	570952.ATVH01000014_gene1829	2.22e-71	235.0	COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,1MV6C@1224|Proteobacteria,2TUJB@28211|Alphaproteobacteria,2JQGJ@204441|Rhodospirillales	204441|Rhodospirillales	C	Domain of unknown function (DUF4445)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
k59_752165_1	1168034.FH5T_17985	2.07e-14	78.2	COG2207@1|root,COG3063@1|root,COG5616@1|root,COG2207@2|Bacteria,COG3063@2|Bacteria,COG5616@2|Bacteria,4NFW7@976|Bacteroidetes	976|Bacteroidetes	K	COGs COG5616 integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,TPR_8
k59_921137_1	472759.Nhal_2137	3.02e-75	237.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,1RMUD@1236|Gammaproteobacteria,1WWH3@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	-	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
k59_1640604_1	383372.Rcas_1588	2.42e-75	244.0	COG1620@1|root,COG1620@2|Bacteria,2G6VR@200795|Chloroflexi	200795|Chloroflexi	C	L-lactate permease	-	-	-	ko:K03303	-	-	-	-	ko00000,ko02000	2.A.14	-	-	Lactate_perm
k59_29615_1	314275.MADE_1009710	2.27e-08	57.0	COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,1RQDA@1236|Gammaproteobacteria,465PG@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K08082	ko02020,map02020	M00493	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,His_kinase
k59_29615_2	485918.Cpin_5734	1.65e-26	105.0	COG3279@1|root,COG3279@2|Bacteria,4NJVD@976|Bacteroidetes,1IS40@117747|Sphingobacteriia	976|Bacteroidetes	K	LytTr DNA-binding domain	-	-	-	ko:K02477	-	-	-	-	ko00000,ko02022	-	-	-	LytTR,Response_reg
k59_1419175_1	596152.DesU5LDRAFT_2639	2.5e-74	248.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,42MER@68525|delta/epsilon subdivisions,2WIYV@28221|Deltaproteobacteria,2MAGR@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	xanthine dehydrogenase a b hammerhead	-	-	1.17.1.4	ko:K11177	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2_2
k59_1142240_2	986075.CathTA2_1660	1.22e-20	93.6	COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,4HBB9@91061|Bacilli	91061|Bacilli	EP	COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
k59_476108_1	1439940.BAY1663_03135	1.77e-35	132.0	COG3146@1|root,COG3146@2|Bacteria,1MU35@1224|Proteobacteria,1RNWI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	-	-	-	ko:K09919	-	-	-	-	ko00000	-	-	-	FemAB_like
k59_1698425_1	1173027.Mic7113_2350	7.25e-06	49.7	COG1071@1|root,COG1071@2|Bacteria,1G00Z@1117|Cyanobacteria,1H7WM@1150|Oscillatoriales	1117|Cyanobacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhA	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
k59_1698425_2	379066.GAU_0749	9.05e-58	188.0	COG0022@1|root,COG0022@2|Bacteria,1ZTA8@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Transketolase, pyrimidine binding domain	-	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
k59_1309072_1	264462.Bd3432	2.2e-84	266.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2MSND@213481|Bdellovibrionales,2WIT0@28221|Deltaproteobacteria	213481|Bdellovibrionales	T	two component, sigma54 specific, transcriptional regulator, Fis family	fgrM	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1086197_2	35754.JNYJ01000020_gene291	6.54e-50	164.0	COG1309@1|root,COG1309@2|Bacteria,2IHGM@201174|Actinobacteria,4DD7T@85008|Micromonosporales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_752185_1	796940.HMPREF9628_01695	0.000142	46.6	COG0332@1|root,COG0332@2|Bacteria,1TP0K@1239|Firmicutes,248V8@186801|Clostridia,25R9C@186804|Peptostreptococcaceae	186801|Clostridia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
k59_476117_1	1254432.SCE1572_32960	3.36e-83	256.0	COG3191@1|root,COG3191@2|Bacteria,1MWDP@1224|Proteobacteria,42YEF@68525|delta/epsilon subdivisions,2WU92@28221|Deltaproteobacteria,2YYRX@29|Myxococcales	28221|Deltaproteobacteria	E	Peptidase family S58	dmpA	-	3.4.11.19	ko:K01266	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S58
k59_1364149_1	861299.J421_6359	4.68e-26	111.0	COG0577@1|root,COG0577@2|Bacteria	861299.J421_6359|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_697527_1	518766.Rmar_1062	4.75e-65	214.0	COG0146@1|root,COG0146@2|Bacteria,4PM5E@976|Bacteroidetes,1FJR8@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	EQ	Hydantoinase B/oxoprolinase	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
k59_1530448_1	379066.GAU_2370	3.18e-25	101.0	COG0704@1|root,COG0704@2|Bacteria	2|Bacteria	P	negative regulation of phosphate transmembrane transport	phoU	GO:0000287,GO:0001558,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006873,GO:0006950,GO:0007154,GO:0008150,GO:0009266,GO:0009267,GO:0009268,GO:0009405,GO:0009408,GO:0009605,GO:0009628,GO:0009892,GO:0009987,GO:0009991,GO:0010468,GO:0010563,GO:0010605,GO:0010629,GO:0010966,GO:0016020,GO:0016036,GO:0019220,GO:0019222,GO:0019725,GO:0019897,GO:0019898,GO:0022898,GO:0030002,GO:0030145,GO:0030320,GO:0030643,GO:0031323,GO:0031324,GO:0031667,GO:0031668,GO:0031669,GO:0032409,GO:0032410,GO:0032412,GO:0032413,GO:0032879,GO:0033554,GO:0034605,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0040008,GO:0042221,GO:0042592,GO:0042594,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043269,GO:0043271,GO:0044070,GO:0044092,GO:0044419,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045936,GO:0046677,GO:0046872,GO:0046914,GO:0046983,GO:0048519,GO:0048523,GO:0048878,GO:0050789,GO:0050794,GO:0050801,GO:0050896,GO:0051049,GO:0051051,GO:0051128,GO:0051174,GO:0051704,GO:0051716,GO:0055062,GO:0055081,GO:0055082,GO:0055083,GO:0060255,GO:0065007,GO:0065008,GO:0065009,GO:0070887,GO:0071214,GO:0071236,GO:0071467,GO:0071496,GO:0071944,GO:0072501,GO:0072502,GO:0072505,GO:0072506,GO:0098771,GO:0104004,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
k59_1752184_1	1122604.JONR01000004_gene851	1.47e-32	130.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1T234@1236|Gammaproteobacteria,1X903@135614|Xanthomonadales	135614|Xanthomonadales	S	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
k59_1032130_1	411464.DESPIG_01724	2.97e-12	72.8	COG5616@1|root,COG5616@2|Bacteria,1RBBE@1224|Proteobacteria,42QR8@68525|delta/epsilon subdivisions,2WN1X@28221|Deltaproteobacteria,2M8NQ@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	CsgG,VCBS
k59_530129_1	1713.JOFV01000021_gene1297	1.94e-28	117.0	COG0659@1|root,COG0659@2|Bacteria,2GJCB@201174|Actinobacteria,4F1TN@85016|Cellulomonadaceae	201174|Actinobacteria	P	Sulfate permease family	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
k59_308135_2	1230460.C495_05412	7.3e-50	163.0	COG0652@1|root,arCOG04767@2157|Archaea,2XTHC@28890|Euryarchaeota,23V5W@183963|Halobacteria	183963|Halobacteria	O	COG0652 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family	ppiA	-	5.2.1.8	ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
k59_1032134_1	1379270.AUXF01000003_gene3394	1.61e-70	225.0	COG4972@1|root,COG4972@2|Bacteria,1ZSYA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	NU	Type IV pilus assembly protein PilM;	-	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
k59_476143_1	314225.ELI_02140	2.62e-134	398.0	COG1866@1|root,COG1866@2|Bacteria,1MWXN@1224|Proteobacteria,2TRC4@28211|Alphaproteobacteria,2JZZG@204457|Sphingomonadales	204457|Sphingomonadales	H	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA	pckA	-	4.1.1.49	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00170	R00341	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_ATP
k59_530143_1	1123072.AUDH01000020_gene2079	1.57e-23	103.0	COG0346@1|root,COG0346@2|Bacteria,1RDDN@1224|Proteobacteria,2U7MP@28211|Alphaproteobacteria,2JV0I@204441|Rhodospirillales	204441|Rhodospirillales	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase_3
k59_1197336_1	706587.Desti_1024	1.19e-23	97.8	COG2761@1|root,COG2761@2|Bacteria,1NXUB@1224|Proteobacteria,42TBH@68525|delta/epsilon subdivisions,2WPJ5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	DsbA oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
k59_1530471_1	1089545.KB913037_gene8249	7.62e-11	67.8	COG4447@1|root,COG4447@2|Bacteria,2H2V0@201174|Actinobacteria,4E90H@85010|Pseudonocardiales	201174|Actinobacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_251646_1	1284352.AOIG01000027_gene543	2.29e-38	142.0	COG2706@1|root,COG2706@2|Bacteria,1TQ3J@1239|Firmicutes,4HBHB@91061|Bacilli,26SEY@186822|Paenibacillaceae	91061|Bacilli	G	3-carboxymuconate cyclase	ykgB3	-	3.1.1.31	ko:K07404	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Lactonase
k59_530157_1	324602.Caur_1119	3.29e-112	329.0	COG1089@1|root,COG1089@2|Bacteria,2G5P2@200795|Chloroflexi,375CR@32061|Chloroflexia	32061|Chloroflexia	M	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose	gmd	-	4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R00888	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
k59_476169_1	113395.AXAI01000027_gene1980	4.09e-68	229.0	COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,2VF1V@28211|Alphaproteobacteria,3JQQ6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Molydopterin dinucleotide binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_6,Fer2,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NAD_binding_1
k59_1032173_1	62977.ACIAD1190	7.31e-29	113.0	COG0538@1|root,COG0538@2|Bacteria,1MW3J@1224|Proteobacteria,1RNMD@1236|Gammaproteobacteria,3NKE6@468|Moraxellaceae	1236|Gammaproteobacteria	C	Isocitrate/isopropylmalate dehydrogenase	icd	GO:0003674,GO:0003824,GO:0004448,GO:0004450,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0022900,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0055114	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	e_coli_core.b1136,iAF1260.b1136,iECDH1ME8569_1439.ECDH1ME8569_1071,iEcDH1_1363.EcDH1_2511,iJN746.PP_4011,iJO1366.b1136,iJR904.b1136,iY75_1357.Y75_RS05930,iYL1228.KPN_01144	Iso_dh
k59_1032173_2	1123288.SOV_4c07280	1.82e-26	107.0	COG0657@1|root,COG0657@2|Bacteria,1UZJD@1239|Firmicutes,4H3AT@909932|Negativicutes	909932|Negativicutes	I	Carboxylesterase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,Peptidase_S9
k59_85283_1	472759.Nhal_0667	6.24e-96	298.0	COG2766@1|root,COG2766@2|Bacteria,1MVW7@1224|Proteobacteria,1RNFJ@1236|Gammaproteobacteria,1WWXB@135613|Chromatiales	135613|Chromatiales	T	PFAM PrkA AAA	-	-	-	ko:K07180	-	-	-	-	ko00000	-	-	-	AAA_PrkA,PrkA
k59_1475635_1	627192.SLG_01130	6.6e-09	57.4	COG0454@1|root,COG0456@2|Bacteria,1PMA3@1224|Proteobacteria,2TUU2@28211|Alphaproteobacteria,2K0BS@204457|Sphingomonadales	204457|Sphingomonadales	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1475635_2	1121930.AQXG01000001_gene1093	8.12e-61	201.0	COG0156@1|root,COG0156@2|Bacteria,4NFBU@976|Bacteroidetes,1INN3@117747|Sphingobacteriia	976|Bacteroidetes	E	PFAM Aminotransferase class I and II	bioF	-	2.3.1.47	ko:K00652	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03210,R10124	RC00004,RC00039,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_1309156_1	1313172.YM304_04120	2.52e-60	209.0	COG1034@1|root,COG1034@2|Bacteria,2GJGX@201174|Actinobacteria,4CMPH@84992|Acidimicrobiia	84992|Acidimicrobiia	C	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region	-	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdop_Fe4S4,Molybdopterin,NADH-G_4Fe-4S_3
k59_1586448_1	243231.GSU1433	4.64e-14	77.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,42MFK@68525|delta/epsilon subdivisions,2WKBU@28221|Deltaproteobacteria,43U0I@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	PFAM extracellular solute-binding protein, family 5	-	-	-	ko:K02035,ko:K13893	ko02010,ko02024,map02010,map02024	M00239,M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.21,3.A.1.5.24	-	-	SBP_bac_5
k59_1419294_1	981384.AEYW01000013_gene538	9.62e-22	95.5	COG2114@1|root,COG2114@2|Bacteria,1NC69@1224|Proteobacteria,2VFPU@28211|Alphaproteobacteria	1224|Proteobacteria	T	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,SnoaL_3
k59_1752240_1	448385.sce6554	2.46e-35	134.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,42M81@68525|delta/epsilon subdivisions,2WIJ5@28221|Deltaproteobacteria,2Z30R@29|Myxococcales	28221|Deltaproteobacteria	C	fumarate reductase, flavoprotein subunit	frdA	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_1309191_1	996637.SGM_4435	3.14e-56	187.0	COG0476@1|root,COG0607@1|root,COG0476@2|Bacteria,COG0607@2|Bacteria,2GJB6@201174|Actinobacteria	201174|Actinobacteria	H	The proteins in this cluster have high sequence similarity to MoeB and are possibly involved in the synthesis of molybdopterin, but there has been no biochemical or physiological characterization. There is also no genetic linkage to other molybdopterin cofactor synthesis proteins. These proteins are	moeB	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006732,GO:0006777,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008146,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009108,GO:0009605,GO:0009607,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0016782,GO:0018130,GO:0019344,GO:0019538,GO:0019637,GO:0019720,GO:0019752,GO:0020012,GO:0030312,GO:0030682,GO:0042783,GO:0043170,GO:0043207,GO:0043436,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0051189,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051810,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0061605,GO:0070566,GO:0071704,GO:0071944,GO:0075136,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.7.80,2.8.1.11	ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	Rhodanese,ThiF
k59_1309191_2	1207063.P24_02291	7.97e-12	64.3	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2TS33@28211|Alphaproteobacteria,2JQG3@204441|Rhodospirillales	204441|Rhodospirillales	E	Cysteine synthase	cysK	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_1142367_1	1110502.TMO_3428	1e-43	151.0	COG4122@1|root,COG4122@2|Bacteria,1R9D7@1224|Proteobacteria,2U823@28211|Alphaproteobacteria,2JRYX@204441|Rhodospirillales	204441|Rhodospirillales	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_24
k59_1142367_2	1177928.TH2_05943	4.09e-16	79.3	COG2114@1|root,COG2114@2|Bacteria,1MV1V@1224|Proteobacteria,2TRUC@28211|Alphaproteobacteria,2JQP6@204441|Rhodospirillales	204441|Rhodospirillales	T	COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain)	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc
k59_975803_1	1286093.C266_23156	5.27e-08	52.4	COG4454@1|root,COG4454@2|Bacteria,1R91G@1224|Proteobacteria,2VSS8@28216|Betaproteobacteria,1K8EJ@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Copper binding proteins, plastocyanin/azurin family	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind
k59_975803_2	1125863.JAFN01000001_gene1072	5.44e-18	79.0	2DREH@1|root,33BDY@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_975803_3	443143.GM18_3141	2.37e-19	86.3	2DQBG@1|root,335T7@2|Bacteria,1R35T@1224|Proteobacteria,42ZVK@68525|delta/epsilon subdivisions,2WV6B@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Glycine/sarcosine/betaine reductase selenoprotein B (GRDB)	-	-	1.21.4.1	ko:K10794	ko00330,map00330	-	R02825	RC00790	ko00000,ko00001,ko01000	-	-	-	GRDB
k59_1254545_1	926550.CLDAP_38220	3.47e-07	54.7	COG0860@1|root,COG0860@2|Bacteria,2G7IE@200795|Chloroflexi	200795|Chloroflexi	M	PFAM cell wall hydrolase autolysin	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3
k59_196203_1	1122603.ATVI01000005_gene3860	9.65e-22	96.3	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1S1MS@1236|Gammaproteobacteria,1X9I0@135614|Xanthomonadales	135614|Xanthomonadales	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1475677_1	497964.CfE428DRAFT_3605	1.19e-24	103.0	COG0364@1|root,COG0364@2|Bacteria,46SHX@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
k59_752294_1	61647.LG71_05455	3.84e-43	156.0	COG3395@1|root,COG3395@2|Bacteria,1MW4G@1224|Proteobacteria,1RN8I@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	ygbK	-	2.7.1.217,2.7.1.219,2.7.1.220	ko:K21948,ko:K22129	-	-	R11706,R11707	-	ko00000,ko01000	-	-	-	DUF1357_C,DUF1537
k59_1530530_2	525904.Tter_1673	3.53e-58	184.0	COG2185@1|root,COG2185@2|Bacteria,2NPGA@2323|unclassified Bacteria	2|Bacteria	I	Cobalamin B12-binding	-	-	5.4.99.2	ko:K01849	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
k59_975816_1	1380391.JIAS01000001_gene2844	1.58e-57	198.0	COG4166@1|root,COG4166@2|Bacteria,1MUVU@1224|Proteobacteria,2TQJX@28211|Alphaproteobacteria,2JQ6J@204441|Rhodospirillales	204441|Rhodospirillales	E	COG4166 ABC-type oligopeptide transport system, periplasmic component	-	-	-	ko:K13893	ko02010,map02010	M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.21,3.A.1.5.24	-	-	SBP_bac_5
k59_476251_1	1123242.JH636435_gene953	4.33e-18	89.7	COG0784@1|root,COG3290@1|root,COG5002@1|root,COG0784@2|Bacteria,COG3290@2|Bacteria,COG5002@2|Bacteria,2J501@203682|Planctomycetes	203682|Planctomycetes	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,Response_reg
k59_584914_1	1517682.HW49_04060	4.09e-14	78.2	COG0457@1|root,COG0457@2|Bacteria,4NERG@976|Bacteroidetes,2FMK5@200643|Bacteroidia,22X3E@171551|Porphyromonadaceae	976|Bacteroidetes	S	Oxygen tolerance	batD	-	-	-	-	-	-	-	-	-	-	-	BatD,TPR_2
k59_1254571_2	457415.HMPREF1006_00512	1.25e-24	101.0	COG0172@1|root,COG0172@2|Bacteria,3T9VY@508458|Synergistetes	508458|Synergistetes	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
k59_808065_1	1144312.PMI09_01583	2.15e-17	83.2	COG2020@1|root,COG2020@2|Bacteria,1RECR@1224|Proteobacteria,2U6MH@28211|Alphaproteobacteria,4BA0U@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	Isoprenylcysteine carboxyl methyltransferase (ICMT) family	-	-	-	-	-	-	-	-	-	-	-	-	ICMT,PEMT
k59_1086372_2	1394178.AWOO02000046_gene6472	5.15e-23	100.0	COG1233@1|root,COG1233@2|Bacteria,2GJAV@201174|Actinobacteria,4EFHW@85012|Streptosporangiales	201174|Actinobacteria	Q	Flavin containing amine oxidoreductase	crtI	-	1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31	ko:K10027	ko00906,ko01100,ko01110,map00906,map01100,map01110	-	R04787,R04798,R04800,R09691,R09692	RC01214,RC02088,RC02605	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase
k59_1142434_1	136993.KB900626_gene1121	1.43e-39	143.0	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,2TTXT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
k59_1419373_1	1235797.C816_01579	2.11e-23	100.0	COG0617@1|root,COG0617@2|Bacteria,1TQ2A@1239|Firmicutes,247XC@186801|Clostridia,2N6XG@216572|Oscillospiraceae	186801|Clostridia	J	Probable RNA and SrmB- binding site of polymerase A	cca	-	2.7.7.19,2.7.7.72	ko:K00970,ko:K00974	ko03013,ko03018,map03013,map03018	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2
k59_1602957_1	1122132.AQYH01000004_gene1648	1.14e-39	143.0	COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,2TSGT@28211|Alphaproteobacteria,4B9G4@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	acetylornithine aminotransferase	argD	GO:0003674,GO:0005488,GO:0005515,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_434907_1	491205.JARQ01000001_gene955	2.97e-86	278.0	COG0178@1|root,COG0178@2|Bacteria,4NFQU@976|Bacteroidetes,1HXMR@117743|Flavobacteriia,3ZNZF@59732|Chryseobacterium	976|Bacteroidetes	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA2	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_266643_1	587753.EY04_17825	9.31e-53	180.0	COG0624@1|root,COG0624@2|Bacteria,1MVUX@1224|Proteobacteria,1RPPD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia	-	-	3.5.1.6,3.5.1.87	ko:K06016	ko00240,ko01100,map00240,map01100	M00046	R00905,R04666	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
k59_1048683_1	572480.Arnit_2809	2.75e-09	60.8	COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,42PY0@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	ko:K01138	-	-	-	-	ko00000,ko01000	-	-	-	Lactamase_B
k59_1602977_1	926569.ANT_15920	2.4e-18	82.8	COG1189@1|root,COG1189@2|Bacteria,2G6BX@200795|Chloroflexi	200795|Chloroflexi	J	Ribosomal RNA methyltransferase RrmJ FtsJ	-	-	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
k59_325574_1	530564.Psta_0200	4.5e-80	253.0	COG0493@1|root,COG0493@2|Bacteria,2IXFM@203682|Planctomycetes	203682|Planctomycetes	C	COG0493 NADPH-dependent glutamate synthase beta chain and	-	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
k59_1326542_1	266835.14023568	2.14e-27	108.0	COG0604@1|root,COG0604@2|Bacteria,1RKY8@1224|Proteobacteria,2UAWJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_zinc_N,ADH_zinc_N_2
k59_1102977_1	1238182.C882_3236	5.58e-12	66.6	COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,2TSTN@28211|Alphaproteobacteria,2JQ1M@204441|Rhodospirillales	204441|Rhodospirillales	K	Belongs to the ParB family	parB	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
k59_1102977_2	1238182.C882_3252	3.35e-38	139.0	COG1466@1|root,COG1466@2|Bacteria,1R8PA@1224|Proteobacteria,2U1KQ@28211|Alphaproteobacteria,2JQE9@204441|Rhodospirillales	204441|Rhodospirillales	L	DNA polymerase III, delta subunit	holA	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
k59_1048723_1	754476.Q7A_1167	1.36e-67	218.0	COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,1RMQU@1236|Gammaproteobacteria,45ZST@72273|Thiotrichales	72273|Thiotrichales	H	MoeA N-terminal region (domain I and II)	-	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MobB,MoeA_C,MoeA_N,NTP_transf_3
k59_379788_1	283942.IL1071	1.16e-31	123.0	COG2234@1|root,COG2234@2|Bacteria,1MWBX@1224|Proteobacteria,1RYHQ@1236|Gammaproteobacteria,2QF3Q@267893|Idiomarinaceae	1236|Gammaproteobacteria	S	Peptidase M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28,fn3
k59_546231_1	1122176.KB903576_gene5010	3.56e-66	220.0	COG2133@1|root,COG4886@1|root,COG2133@2|Bacteria,COG4886@2|Bacteria,4NF0B@976|Bacteroidetes,1IVY8@117747|Sphingobacteriia	976|Bacteroidetes	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6,GSDH
k59_600772_1	926569.ANT_11300	5.97e-83	265.0	COG0747@1|root,COG0747@2|Bacteria,2G5NC@200795|Chloroflexi	200795|Chloroflexi	E	PFAM extracellular solute-binding protein, family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_266705_1	240015.ACP_1714	7.91e-78	247.0	COG1239@1|root,COG1239@2|Bacteria,3Y3FM@57723|Acidobacteria,2JHY2@204432|Acidobacteriia	204432|Acidobacteriia	H	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX	-	-	6.6.1.1	ko:K03405	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	-	Sigma54_activat
k59_1545510_1	340177.Cag_0727	2.59e-30	114.0	COG1051@1|root,COG1051@2|Bacteria,1FE2C@1090|Chlorobi	1090|Chlorobi	F	Belongs to the Nudix hydrolase family	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
k59_434977_1	526227.Mesil_3294	1.22e-38	143.0	COG0683@1|root,COG0683@2|Bacteria,1WKAP@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_1656852_1	402881.Plav_2899	4.63e-74	233.0	COG1024@1|root,COG1024@2|Bacteria,1MU0B@1224|Proteobacteria,2TQW3@28211|Alphaproteobacteria,1JNC0@119043|Rhodobiaceae	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase/isomerase	hibch	-	3.1.2.4,4.2.1.17	ko:K01692,ko:K05605	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01200,map01212	M00013,M00032,M00087	R03026,R03045,R03158,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05064,R05595,R06411,R06412,R06942,R08093	RC00004,RC00014,RC00137,RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_2
k59_1326586_1	945713.IALB_2637	4.72e-40	143.0	COG0158@1|root,COG0158@2|Bacteria	2|Bacteria	G	fructose 1,6-bisphosphate 1-phosphatase activity	fbp	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005984,GO:0005985,GO:0005986,GO:0005996,GO:0006000,GO:0006002,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016043,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019318,GO:0019319,GO:0019637,GO:0022607,GO:0030388,GO:0034637,GO:0042132,GO:0042578,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046364,GO:0050308,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901135,GO:1901576	3.1.3.11	ko:K03841	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko04152,ko04910,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map04152,map04910	M00003,M00165,M00167,M00344	R00762,R04780	RC00017	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iUTI89_1310.UTI89_C4836,ic_1306.c5329	FBPase
k59_1326586_2	104355.XP_007863381.1	0.000129	43.9	COG0158@1|root,KOG1458@2759|Eukaryota,38D1X@33154|Opisthokonta,3NUA1@4751|Fungi,3UZ5J@5204|Basidiomycota,2264W@155619|Agaricomycetes,3H201@355688|Agaricomycetes incertae sedis	4751|Fungi	G	Fructose-1-6-bisphosphatase, N-terminal domain	FBP1	GO:0000166,GO:0001558,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005984,GO:0005985,GO:0005986,GO:0005996,GO:0006000,GO:0006002,GO:0006006,GO:0006094,GO:0006109,GO:0006110,GO:0006111,GO:0006140,GO:0006793,GO:0006796,GO:0006950,GO:0007154,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009267,GO:0009311,GO:0009312,GO:0009605,GO:0009889,GO:0009890,GO:0009892,GO:0009894,GO:0009895,GO:0009966,GO:0009968,GO:0009987,GO:0009991,GO:0010035,GO:0010038,GO:0010563,GO:0010646,GO:0010648,GO:0010675,GO:0010677,GO:0010906,GO:0016043,GO:0016051,GO:0016208,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0017076,GO:0019203,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019637,GO:0022607,GO:0023051,GO:0023057,GO:0030246,GO:0030308,GO:0030388,GO:0030554,GO:0030808,GO:0030809,GO:0030811,GO:0030812,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031329,GO:0031330,GO:0031667,GO:0031668,GO:0031669,GO:0032026,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034637,GO:0035690,GO:0036094,GO:0040008,GO:0042132,GO:0042149,GO:0042221,GO:0042325,GO:0042326,GO:0042493,GO:0042578,GO:0042594,GO:0042597,GO:0043167,GO:0043168,GO:0043169,GO:0043255,GO:0043467,GO:0043470,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045820,GO:0045912,GO:0045926,GO:0045934,GO:0045936,GO:0045980,GO:0046351,GO:0046364,GO:0046578,GO:0046580,GO:0046872,GO:0048029,GO:0048519,GO:0048523,GO:0048583,GO:0048585,GO:0050308,GO:0050789,GO:0050794,GO:0050896,GO:0051056,GO:0051058,GO:0051128,GO:0051171,GO:0051172,GO:0051174,GO:0051193,GO:0051195,GO:0051196,GO:0051198,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051716,GO:0062012,GO:0062014,GO:0065003,GO:0065007,GO:0070887,GO:0071241,GO:0071248,GO:0071286,GO:0071496,GO:0071704,GO:0071840,GO:0072593,GO:0080090,GO:0097159,GO:0097367,GO:1900371,GO:1900372,GO:1900542,GO:1900543,GO:1901135,GO:1901265,GO:1901363,GO:1901576,GO:1902531,GO:1902532,GO:1903578,GO:1903579,GO:2001169,GO:2001170	3.1.3.11	ko:K03841	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko04152,ko04910,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map04152,map04910	M00003,M00165,M00167,M00344	R00762,R04780	RC00017	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iMM904.YLR377C,iND750.YLR377C	FBPase
k59_715267_1	981369.JQMJ01000001_gene6694	2.05e-25	109.0	COG5002@1|root,COG5002@2|Bacteria,2GIX7@201174|Actinobacteria,2NFWC@228398|Streptacidiphilus	201174|Actinobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K07642	ko02020,map02020	M00450,M00645,M00646,M00648	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
k59_379824_1	1121924.ATWH01000003_gene1430	2.88e-69	227.0	COG0520@1|root,COG0520@2|Bacteria,2GP7W@201174|Actinobacteria	201174|Actinobacteria	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
k59_266725_1	1121904.ARBP01000015_gene188	1.71e-34	140.0	COG2192@1|root,COG2192@2|Bacteria,4NEV9@976|Bacteroidetes,47JR5@768503|Cytophagia	976|Bacteroidetes	O	PFAM Carbamoyltransferase	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
k59_600803_1	93220.LV28_23035	7.15e-92	280.0	COG0683@1|root,COG0683@2|Bacteria,1N76S@1224|Proteobacteria,2VKWN@28216|Betaproteobacteria,1KFE3@119060|Burkholderiaceae	28216|Betaproteobacteria	E	amino acid	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_1492797_1	1317124.DW2_12025	3.65e-24	102.0	COG4148@1|root,COG4148@2|Bacteria,1MU8K@1224|Proteobacteria,2TR1Z@28211|Alphaproteobacteria,2XMP6@285107|Thioclava	28211|Alphaproteobacteria	P	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system	modC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.3.29	ko:K02017	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran,TOBE
k59_1492797_2	99598.Cal7507_5195	2.95e-07	53.5	COG1118@1|root,COG4149@1|root,COG1118@2|Bacteria,COG4149@2|Bacteria,1G08P@1117|Cyanobacteria,1HKT5@1161|Nostocales	1117|Cyanobacteria	P	TIGRFAM molybdate ABC transporter, permease protein	modB	-	3.6.3.29	ko:K02017,ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran,BPD_transp_1
k59_715311_1	272134.KB731324_gene4640	9.46e-07	55.1	COG1295@1|root,COG1295@2|Bacteria,1G3Q3@1117|Cyanobacteria,1H96S@1150|Oscillatoriales	1117|Cyanobacteria	S	Virulence factor BrkB	rbn	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
k59_824379_1	1041146.ATZB01000023_gene2667	2.79e-90	273.0	COG0650@1|root,COG0650@2|Bacteria,1MXV5@1224|Proteobacteria,2U0GZ@28211|Alphaproteobacteria,4B9RM@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	NADH dehydrogenase	hycD	-	-	-	-	-	-	-	-	-	-	-	NADHdh
k59_379858_1	1089544.KB912942_gene1865	2.71e-11	64.7	COG0208@1|root,COG0208@2|Bacteria,2GKGZ@201174|Actinobacteria	201174|Actinobacteria	F	PFAM Fatty acid desaturase, type 2	-	-	1.14.19.11,1.14.19.2,1.14.19.26	ko:K03921	ko00061,ko01040,ko01212,map00061,map01040,map01212	-	R03370,R08161,R11108,R11109	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase_2
k59_45118_2	670487.Ocepr_0357	1.25e-07	51.2	COG0517@1|root,COG0517@2|Bacteria,1WNHR@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	COGs COG2905 signal-transduction protein containing cAMP-binding and CBS domains	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_266751_1	1185876.BN8_00694	3.94e-43	151.0	COG2017@1|root,COG2017@2|Bacteria,4NF5G@976|Bacteroidetes,47KAR@768503|Cytophagia	976|Bacteroidetes	G	Converts alpha-aldose to the beta-anomer	-	-	5.1.3.3	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	M00632	R01602,R10619	RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldose_epim
k59_266751_2	1191523.MROS_0031	1.17e-27	111.0	COG4146@1|root,COG4146@2|Bacteria	2|Bacteria	S	symporter activity	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
k59_1492817_2	1380350.JIAP01000003_gene5128	2.35e-23	92.4	COG3278@1|root,COG3278@2|Bacteria,1N9ZN@1224|Proteobacteria,2UH1E@28211|Alphaproteobacteria,43KSU@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	O	Belongs to the heme-copper respiratory oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_767895_1	46234.ANA_C13142	4.24e-50	174.0	COG3385@1|root,COG3385@2|Bacteria,1G2T1@1117|Cyanobacteria,1HMX0@1161|Nostocales	1117|Cyanobacteria	L	PFAM Transposase DDE domain	-	-	-	ko:K07495	-	-	-	-	ko00000	-	-	-	DDE_5,DDE_Tnp_1
k59_879685_1	421052.F945_00122	1.18e-37	142.0	COG2951@1|root,COG3409@1|root,COG2951@2|Bacteria,COG3409@2|Bacteria,1MUZ3@1224|Proteobacteria,1RMQ6@1236|Gammaproteobacteria,3NIM8@468|Moraxellaceae	1236|Gammaproteobacteria	M	Lytic murein transglycosylase	-	-	5.1.3.15	ko:K01792,ko:K08305	ko00010,ko01100,ko01110,ko01120,ko01130,map00010,map01100,map01110,map01120,map01130	-	R02739	RC00563	ko00000,ko00001,ko01000,ko01011	-	GH103	-	Aldose_epim,PG_binding_1,SLT_2
k59_210637_1	1429046.RR21198_3882	3.53e-49	167.0	2ANI9@1|root,31DH5@2|Bacteria,2GJE8@201174|Actinobacteria,4FZE9@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_546317_1	279714.FuraDRAFT_0067	9.3e-54	184.0	COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,2VIBV@28216|Betaproteobacteria,2KQ8N@206351|Neisseriales	206351|Neisseriales	T	Domain of unknown function (DUF3329)	phoR	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF3329,HATPase_c,HisKA,PAS_8
k59_992773_2	595537.Varpa_1505	1.16e-15	74.3	COG1733@1|root,COG1733@2|Bacteria,1RIZT@1224|Proteobacteria,2VT1N@28216|Betaproteobacteria,4AF9F@80864|Comamonadaceae	28216|Betaproteobacteria	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
k59_879709_1	497321.C664_17827	3.86e-12	71.6	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VP9Y@28216|Betaproteobacteria,2KVNY@206389|Rhodocyclales	206389|Rhodocyclales	T	Histidine kinase	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,sCache_3_3
k59_325710_1	1283300.ATXB01000002_gene3068	1.4e-104	315.0	COG2133@1|root,COG2133@2|Bacteria,1MV2E@1224|Proteobacteria,1RNGN@1236|Gammaproteobacteria,1XFWW@135618|Methylococcales	135618|Methylococcales	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
k59_824409_1	1472716.KBK24_0123535	1.14e-77	248.0	COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,2VJ2W@28216|Betaproteobacteria,1K2WR@119060|Burkholderiaceae	28216|Betaproteobacteria	S	transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
k59_157077_1	1469607.KK073768_gene4663	5.51e-29	114.0	COG3547@1|root,COG3547@2|Bacteria,1GA7N@1117|Cyanobacteria,1HTM7@1161|Nostocales	1117|Cyanobacteria	L	PFAM Transposase IS116 IS110 IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_493612_2	113395.AXAI01000005_gene3814	4.67e-38	142.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2TUKZ@28211|Alphaproteobacteria,3JST2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	Belongs to the amidase family	-	-	3.5.1.4,6.3.5.6,6.3.5.7	ko:K01426,ko:K02433	ko00330,ko00360,ko00380,ko00627,ko00643,ko00970,ko01100,ko01120,map00330,map00360,map00380,map00627,map00643,map00970,map01100,map01120	-	R02540,R03096,R03180,R03905,R03909,R04212,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
k59_938829_2	1143323.M787_0652	1.7e-40	145.0	COG0688@1|root,COG0688@2|Bacteria,2JFMN@204428|Chlamydiae	204428|Chlamydiae	I	Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)	psd	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
k59_210672_1	1192034.CAP_0946	7.4e-47	162.0	COG1024@1|root,COG1024@2|Bacteria,1MXHV@1224|Proteobacteria,42QU2@68525|delta/epsilon subdivisions,2WMSF@28221|Deltaproteobacteria,2YYYW@29|Myxococcales	28221|Deltaproteobacteria	I	enoyl-CoA hydratase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
k59_938832_1	1313172.YM304_00360	2.42e-65	224.0	COG1404@1|root,COG1404@2|Bacteria,2GK3D@201174|Actinobacteria	201174|Actinobacteria	O	Belongs to the peptidase S8 family	sbtB	-	-	-	-	-	-	-	-	-	-	-	Big_3_5,Inhibitor_I9,PA,Peptidase_S8
k59_715394_2	797209.ZOD2009_18884	3.87e-22	90.5	COG4392@1|root,arCOG06625@2157|Archaea,2XZ4G@28890|Euryarchaeota,23WTM@183963|Halobacteria	183963|Halobacteria	S	Branched-chain amino acid transport protein (AzlD)	-	-	-	-	-	-	-	-	-	-	-	-	AzlD
k59_715394_3	1215092.PA6_030_00020	1.02e-08	56.2	COG1296@1|root,COG1296@2|Bacteria,1MVGN@1224|Proteobacteria,1RZYJ@1236|Gammaproteobacteria,1YGFU@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	E	AzlC protein	azlC	-	-	-	-	-	-	-	-	-	-	-	AzlC
k59_938845_1	329726.AM1_6258	4.41e-47	165.0	COG3464@1|root,COG3464@2|Bacteria,1G42D@1117|Cyanobacteria	1117|Cyanobacteria	L	Helix-turn-helix domain of transposase family ISL3	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3
k59_1657004_1	1380394.JADL01000001_gene2883	2.5e-84	271.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2TS19@28211|Alphaproteobacteria,2JQ7S@204441|Rhodospirillales	204441|Rhodospirillales	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC,Ribonuc_red_lgN
k59_767959_1	401526.TcarDRAFT_1490	5.13e-19	91.7	COG1538@1|root,COG1538@2|Bacteria,1TRDS@1239|Firmicutes,4H2S7@909932|Negativicutes	909932|Negativicutes	MU	outer membrane efflux protein	tolC	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_600889_1	397287.C807_03488	6.56e-63	215.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1TPK8@1239|Firmicutes,247RW@186801|Clostridia,27UCH@186928|unclassified Lachnospiraceae	186801|Clostridia	G	PEP-utilising enzyme, mobile domain	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_715420_1	1132441.KI519454_gene52	4.64e-63	209.0	COG0477@1|root,COG2814@2|Bacteria,2I41G@201174|Actinobacteria,1WBJ8@1268|Micrococcaceae	201174|Actinobacteria	EGP	Sugar (and other) transporter	-	-	-	ko:K06610	-	-	-	-	ko00000,ko02000	2.A.1.1.27	-	-	MFS_1,Sugar_tr
k59_101877_1	580332.Slit_2404	1.25e-08	55.1	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2VJ55@28216|Betaproteobacteria,44V6P@713636|Nitrosomonadales	28216|Betaproteobacteria	H	PFAM thiamine pyrophosphate	ilvI	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_101877_2	1120999.JONM01000006_gene2416	1.11e-82	248.0	COG0440@1|root,COG0440@2|Bacteria,1RAGN@1224|Proteobacteria,2VH1H@28216|Betaproteobacteria,2KQ6A@206351|Neisseriales	206351|Neisseriales	E	Psort location Cytoplasmic, score 8.96	ilvN	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C
k59_655534_1	675635.Psed_5660	1.5e-46	163.0	COG2896@1|root,COG2896@2|Bacteria,2GN0V@201174|Actinobacteria,4DXVJ@85010|Pseudonocardiales	201174|Actinobacteria	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
k59_655536_2	1051632.TPY_3332	2.48e-32	122.0	COG0491@1|root,COG0491@2|Bacteria,1UKF6@1239|Firmicutes,24NP8@186801|Clostridia	1239|Firmicutes	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_1103162_1	472759.Nhal_3009	9.07e-29	110.0	COG2927@1|root,COG2927@2|Bacteria,1MZ3V@1224|Proteobacteria,1S94K@1236|Gammaproteobacteria,1WYQ1@135613|Chromatiales	135613|Chromatiales	L	DNA polymerase III, chi subunit	-	-	2.7.7.7	ko:K02339	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_chi
k59_824498_1	926569.ANT_23750	1.4e-68	221.0	COG0141@1|root,COG0141@2|Bacteria,2G5KP@200795|Chloroflexi	200795|Chloroflexi	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
k59_328454_2	1224318.DT73_12880	5.47e-07	55.1	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	(ABC) transporter	ybhF	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006855,GO:0008150,GO:0015562,GO:0015893,GO:0016020,GO:0022857,GO:0042221,GO:0042493,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1274919_1	1396141.BATP01000006_gene5468	6.77e-35	136.0	COG3033@1|root,COG3033@2|Bacteria,46X9C@74201|Verrucomicrobia,2IV3F@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	Beta-eliminating lyase	-	-	4.1.99.1	ko:K01667	ko00380,map00380	-	R00673	RC00209,RC00355	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
k59_1215535_1	102129.Lepto7375DRAFT_7541	2.58e-38	137.0	COG1484@1|root,COG1484@2|Bacteria,1GBSA@1117|Cyanobacteria	1117|Cyanobacteria	L	PFAM IstB-like ATP binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
k59_1438302_1	382464.ABSI01000012_gene2198	2.45e-31	127.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,TPR_11,TPR_16,TPR_7,TPR_8,Trans_reg_C
k59_676636_1	326424.FRAAL6153	2.6e-85	271.0	COG1249@1|root,COG1249@2|Bacteria,2GPG1@201174|Actinobacteria,4EU8T@85013|Frankiales	201174|Actinobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation	sthA	-	1.6.1.1	ko:K00322	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_342573_1	1210884.HG799463_gene10112	1.86e-06	55.1	COG0438@1|root,COG0438@2|Bacteria,2IWW3@203682|Planctomycetes	203682|Planctomycetes	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4
k59_842890_1	926569.ANT_30440	2.04e-28	114.0	COG1466@1|root,COG1466@2|Bacteria,2G6XX@200795|Chloroflexi	200795|Chloroflexi	L	TIGRFAM DNA polymerase III, delta' subunit	holA	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
k59_9474_1	580332.Slit_0259	6.74e-33	128.0	COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,2VH9S@28216|Betaproteobacteria,44VQA@713636|Nitrosomonadales	28216|Betaproteobacteria	T	Histidine kinase	algZ	-	2.7.13.3	ko:K08082	ko02020,map02020	M00493	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	His_kinase
k59_1010195_1	1037409.BJ6T_61780	5.06e-49	179.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2TRWM@28211|Alphaproteobacteria,3JVS5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1121604_1	1122135.KB893157_gene354	1.23e-59	203.0	COG0633@1|root,COG2114@1|root,COG0633@2|Bacteria,COG2114@2|Bacteria,1N5XC@1224|Proteobacteria,2TRGX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	CT	Adenylate Guanylate cyclase	cyaA	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2,Guanylate_cyc
k59_9486_1	1562701.BBOF01000044_gene1257	2.25e-31	132.0	COG0419@1|root,COG0419@2|Bacteria,1R4K4@1224|Proteobacteria,2VJVF@28216|Betaproteobacteria,1K5QE@119060|Burkholderiaceae	28216|Betaproteobacteria	L	AAA domain	recF	-	-	-	-	-	-	-	-	-	-	-	AAA_23
k59_1176767_1	1121396.KB893077_gene734	2.41e-33	128.0	COG2199@1|root,COG3706@2|Bacteria,1RERI@1224|Proteobacteria,42S3X@68525|delta/epsilon subdivisions,2WNF2@28221|Deltaproteobacteria,2MNCH@213118|Desulfobacterales	28221|Deltaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	iAF987.Gmet_2982	GGDEF
k59_1510359_2	1380394.JADL01000017_gene554	1.16e-25	103.0	COG0730@1|root,COG0730@2|Bacteria,1RACD@1224|Proteobacteria,2U9JT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
k59_1176781_1	697282.Mettu_3259	1.07e-115	344.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,1XEUM@135618|Methylococcales	135618|Methylococcales	P	PFAM Ammonium Transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_231898_1	926569.ANT_08060	1.02e-80	251.0	COG0449@1|root,COG0449@2|Bacteria,2G5V6@200795|Chloroflexi	200795|Chloroflexi	M	PFAM sugar isomerase (SIS)	-	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	SIS
k59_1287952_1	83406.HDN1F_19780	3e-16	75.9	COG1024@1|root,COG1024@2|Bacteria,1MVEC@1224|Proteobacteria,1RP85@1236|Gammaproteobacteria,1J4DN@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	COG1024 Enoyl-CoA hydratase carnithine racemase	liuC	-	4.2.1.18	ko:K13766	ko00280,ko01100,map00280,map01100	M00036	R02085	RC02416	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
k59_1287952_2	83406.HDN1F_19790	6.31e-79	255.0	COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,1RM95@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Acetyl propionyl-CoA carboxylase alpha subunit	-	-	6.4.1.4	ko:K01968	ko00280,ko01100,map00280,map01100	M00036	R04138	RC00367,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
k59_454330_2	926569.ANT_02020	2.13e-56	184.0	COG1788@1|root,COG1788@2|Bacteria,2G6IM@200795|Chloroflexi	200795|Chloroflexi	I	Coenzyme A transferase	-	-	2.8.3.12	ko:K01039	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
k59_899284_1	247490.KSU1_C0336	3.69e-20	89.7	COG1690@1|root,COG1690@2|Bacteria,2IWY4@203682|Planctomycetes	203682|Planctomycetes	S	Belongs to the RtcB family	rtcB	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
k59_1065597_1	289376.THEYE_A0408	1.57e-35	132.0	COG0671@1|root,COG0671@2|Bacteria	2|Bacteria	I	phosphatidate phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	PAP2_3
k59_899293_1	1346330.M472_07765	2.85e-17	86.7	COG0760@1|root,COG0760@2|Bacteria,4NDZZ@976|Bacteroidetes,1INT0@117747|Sphingobacteriia	976|Bacteroidetes	O	peptidylprolyl isomerase	ppiD	-	5.2.1.8	ko:K01802,ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_2,Rotamase_3,SurA_N_2
k59_1677133_1	493475.GARC_0327	6.23e-10	65.1	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,464UX@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	COG0474 Cation transport ATPase	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
k59_1399166_2	713586.KB900536_gene891	1.43e-22	90.9	COG2963@1|root,COG2963@2|Bacteria,1N3E0@1224|Proteobacteria,1S9T7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	COG2963 Transposase and inactivated derivatives	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_1399166_3	1118060.CAGZ01000031_gene1371	2.14e-11	64.3	COG2801@1|root,COG2801@2|Bacteria	2|Bacteria	L	transposition	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_2
k59_454348_1	179408.Osc7112_3493	3.05e-13	74.7	COG0665@1|root,COG0665@2|Bacteria,1GPXB@1117|Cyanobacteria,1HHVY@1150|Oscillatoriales	1117|Cyanobacteria	E	TIGRFAM glycine oxidase ThiO	thiO	-	1.4.3.19,2.8.1.10	ko:K03149,ko:K03153	ko00730,ko01100,map00730,map01100	-	R07463,R10247	RC01788,RC03096,RC03097,RC03461	ko00000,ko00001,ko01000	-	-	-	DAO
k59_732439_1	743722.Sph21_3376	4.57e-37	137.0	COG0667@1|root,COG0667@2|Bacteria,4NEDK@976|Bacteroidetes,1IP4A@117747|Sphingobacteriia	976|Bacteroidetes	C	PFAM aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_398504_1	1207063.P24_09936	4.47e-58	192.0	COG3552@1|root,COG3552@2|Bacteria,1MUHH@1224|Proteobacteria,2TSXR@28211|Alphaproteobacteria,2JR83@204441|Rhodospirillales	204441|Rhodospirillales	S	VWA domain containing CoxE-like protein	-	-	-	ko:K07161	-	-	-	-	ko00000	-	-	-	VWA_CoxE
k59_1065630_1	1459636.NTE_00528	1.27e-26	104.0	COG0589@1|root,arCOG02053@2157|Archaea	2157|Archaea	T	COG0589 Universal stress protein UspA and related nucleotide-binding proteins	-	-	-	ko:K03294,ko:K20989	-	-	-	-	ko00000,ko02000	2.A.21.6,2.A.3.2	-	-	Usp
k59_454366_1	693986.MOC_5451	5.73e-92	276.0	COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,1JTSW@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve,rve_3
k59_1677154_1	287.DR97_4207	6.95e-77	251.0	COG3225@1|root,COG3225@2|Bacteria,1MY63@1224|Proteobacteria,1RP5E@1236|Gammaproteobacteria,1YFFN@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	N	ABC-type uncharacterized transport system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux
k59_1677154_2	1384056.N787_00035	7.21e-19	84.0	COG1277@1|root,COG1277@2|Bacteria,1NZZ9@1224|Proteobacteria,1RP6C@1236|Gammaproteobacteria,1X35D@135614|Xanthomonadales	135614|Xanthomonadales	S	COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
k59_1065637_1	1120950.KB892707_gene4945	7.89e-54	186.0	COG1123@1|root,COG4172@2|Bacteria,2H2BQ@201174|Actinobacteria,4DWHF@85009|Propionibacteriales	201174|Actinobacteria	P	ATPases associated with a variety of cellular activities	ykoD	-	-	ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
k59_287484_2	984262.SGRA_1614	9.98e-37	132.0	COG1595@1|root,COG1595@2|Bacteria,4NEFR@976|Bacteroidetes,1IXQF@117747|Sphingobacteriia	976|Bacteroidetes	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_1566041_2	1122919.KB905624_gene87	1.14e-08	58.5	COG0477@1|root,COG2814@2|Bacteria,1TQHD@1239|Firmicutes,4HBCZ@91061|Bacilli,26QDE@186822|Paenibacillaceae	91061|Bacilli	EGP	major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,MFS_3,Sugar_tr
k59_1121719_1	1429916.X566_21445	5.66e-53	182.0	COG0008@1|root,COG0008@2|Bacteria,1MUC8@1224|Proteobacteria,2TRKX@28211|Alphaproteobacteria,3JUGQ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	glutaminyl-tRNA synthetase	glnS	-	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
k59_1677164_1	926569.ANT_27060	1.43e-53	175.0	COG1136@1|root,COG1136@2|Bacteria,2G69N@200795|Chloroflexi	200795|Chloroflexi	P	Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1566049_1	1077285.AGDG01000039_gene3974	1.06e-14	73.2	COG0558@1|root,COG0558@2|Bacteria,4NGNI@976|Bacteroidetes,2FM7W@200643|Bacteroidia,4ANUB@815|Bacteroidaceae	976|Bacteroidetes	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA1	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf,DUF4833
k59_1065651_1	981369.JQMJ01000004_gene340	9.03e-117	354.0	COG1129@1|root,COG1129@2|Bacteria,2GJ3F@201174|Actinobacteria,2NGR7@228398|Streptacidiphilus	201174|Actinobacteria	G	ATPases associated with a variety of cellular activities	rbsA	-	3.6.3.17	ko:K10562	ko02010,map02010	M00220	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.9	-	-	ABC_tran
k59_398537_1	234267.Acid_3586	4.43e-39	148.0	COG1404@1|root,COG1404@2|Bacteria,3Y2EZ@57723|Acidobacteria	57723|Acidobacteria	O	Beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	SBBP
k59_509691_1	296587.XP_002503795.1	2.9e-10	62.8	2E3GZ@1|root,2SAJB@2759|Eukaryota,381P2@33090|Viridiplantae,34NDB@3041|Chlorophyta	3041|Chlorophyta	S	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_7
k59_231990_1	215803.DB30_5552	1.04e-71	241.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,42M33@68525|delta/epsilon subdivisions,2WJGS@28221|Deltaproteobacteria,2YU96@29|Myxococcales	28221|Deltaproteobacteria	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	acnA	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k59_899367_1	96561.Dole_2382	3.66e-37	142.0	28J7E@1|root,2Z92U@2|Bacteria,1NAE1@1224|Proteobacteria,42P08@68525|delta/epsilon subdivisions,2WJXV@28221|Deltaproteobacteria,2MI0F@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4105)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4105
k59_1121751_1	1479235.KK366039_gene3098	1.61e-52	175.0	COG4106@1|root,COG4106@2|Bacteria,1Q2Y3@1224|Proteobacteria,1S2MJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_31
k59_64940_1	326424.FRAAL2285	8.08e-25	101.0	COG2062@1|root,COG2062@2|Bacteria,2GJ0I@201174|Actinobacteria,4ETFS@85013|Frankiales	201174|Actinobacteria	T	PFAM Phosphoglycerate mutase	sixA	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
k59_64942_1	1232410.KI421421_gene3520	7.37e-64	217.0	COG1449@1|root,COG1449@2|Bacteria,1PUYM@1224|Proteobacteria,42MQP@68525|delta/epsilon subdivisions,2WKP2@28221|Deltaproteobacteria,43SBY@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Domain of unknown function (DUF3536)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3536,Glyco_hydro_57
k59_1343558_2	1453500.AT05_05220	9.98e-06	50.4	COG0811@1|root,COG0811@2|Bacteria,4NEA2@976|Bacteroidetes,1HXZK@117743|Flavobacteriia	976|Bacteroidetes	U	Mota tolq exbb proton channel	exbB	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
k59_1455252_1	472759.Nhal_3186	5.01e-40	137.0	COG5502@1|root,COG5502@2|Bacteria,1NB8V@1224|Proteobacteria,1SETZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Uncharacterized conserved protein (DUF2267)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2267
k59_1233594_1	158500.BV97_00690	1.84e-64	201.0	COG1610@1|root,COG1610@2|Bacteria,1RGZS@1224|Proteobacteria,2U7DJ@28211|Alphaproteobacteria,2K3W5@204457|Sphingomonadales	204457|Sphingomonadales	S	Yqey-like protein	-	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
k59_787942_2	1089553.Tph_c08400	2.02e-47	159.0	COG0634@1|root,COG0634@2|Bacteria,1V1C9@1239|Firmicutes,24FR4@186801|Clostridia,42G9G@68295|Thermoanaerobacterales	186801|Clostridia	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	hpt	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
k59_899385_1	1089550.ATTH01000001_gene426	1.39e-22	101.0	COG1629@1|root,COG4771@2|Bacteria,4NDX3@976|Bacteroidetes,1FISC@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	P	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec
k59_620744_1	1267534.KB906754_gene3162	2e-30	124.0	COG0577@1|root,COG0577@2|Bacteria,3Y6DE@57723|Acidobacteria,2JM90@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_342748_1	1121272.KB903290_gene4600	7.42e-30	110.0	COG3797@1|root,COG3797@2|Bacteria,2GPDB@201174|Actinobacteria,4DIUT@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF1697)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1697
k59_1399255_1	1463857.JOFZ01000005_gene3353	4.58e-31	124.0	COG4819@1|root,COG4819@2|Bacteria,2IBCD@201174|Actinobacteria	201174|Actinobacteria	E	Ethanolamine utilisation protein EutA	-	-	-	ko:K04019	ko00564,ko01100,map00564,map01100	-	R00749	RC00370	ko00000,ko00001	-	-	-	EutA
k59_676834_1	1408473.JHXO01000007_gene777	4.89e-12	72.4	COG1597@1|root,COG1597@2|Bacteria,4NGPY@976|Bacteroidetes,2FP27@200643|Bacteroidia	976|Bacteroidetes	I	lipid kinase, YegS Rv2252 BmrU family	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
k59_1121786_1	1040989.AWZU01000008_gene3776	1.45e-105	319.0	COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,2U0D0@28211|Alphaproteobacteria,3JURI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Glucose-6-phosphate dehydrogenase, NAD binding domain	-	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
k59_64965_1	243231.GSU1866	6.73e-62	204.0	COG1875@1|root,COG1875@2|Bacteria,1MUX1@1224|Proteobacteria,42MK9@68525|delta/epsilon subdivisions,2WJ1C@28221|Deltaproteobacteria,43UHM@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	SMART Nucleotide binding protein, PINc	phoH1	-	-	ko:K07175	-	-	-	-	ko00000	-	-	-	PIN_4,PhoH
k59_342757_1	1469607.KK073768_gene4661	6.33e-74	238.0	COG0492@1|root,COG3437@1|root,COG0492@2|Bacteria,COG3437@2|Bacteria,1FZX5@1117|Cyanobacteria,1HMXM@1161|Nostocales	1117|Cyanobacteria	KOT	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Response_reg
k59_787960_1	319003.Bra1253DRAFT_07169	9.99e-32	128.0	COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,3JTQ7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DZR,Guanylate_cyc,SAM_1
k59_1176948_1	1449353.JQMQ01000005_gene876	5.09e-09	57.4	COG0341@1|root,COG0341@2|Bacteria,2GJRS@201174|Actinobacteria,2NF2R@228398|Streptacidiphilus	201174|Actinobacteria	U	Protein export membrane protein	secF	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03072,ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
k59_1176948_2	1249975.JQLP01000005_gene1288	8.66e-35	124.0	COG0503@1|root,COG0503@2|Bacteria,4NP7K@976|Bacteroidetes,1I29Z@117743|Flavobacteriia,2P6NA@244698|Gillisia	976|Bacteroidetes	F	Phosphoribosyl transferase domain	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
k59_1176950_1	926569.ANT_21060	2.94e-61	201.0	COG1058@1|root,COG1058@2|Bacteria,2G6DU@200795|Chloroflexi	200795|Chloroflexi	S	PFAM molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CinA,MoCF_biosynth
k59_1677241_1	926561.KB900620_gene2918	3.35e-50	171.0	COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,247IP@186801|Clostridia,3WBAI@53433|Halanaerobiales	186801|Clostridia	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_1568018_1	525897.Dbac_3057	7.59e-53	188.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MQ0@68525|delta/epsilon subdivisions,2WISW@28221|Deltaproteobacteria,2MA4J@213115|Desulfovibrionales	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1178825_1	1187851.A33M_4157	4.73e-59	197.0	COG1232@1|root,COG1232@2|Bacteria,1MX35@1224|Proteobacteria,2TU7I@28211|Alphaproteobacteria,3FDYA@34008|Rhodovulum	28211|Alphaproteobacteria	H	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
k59_1178825_2	1317118.ATO8_12731	4.16e-09	56.6	COG1087@1|root,COG1087@2|Bacteria,1MUHI@1224|Proteobacteria,2TTC7@28211|Alphaproteobacteria,4KKUS@93682|Roseivivax	28211|Alphaproteobacteria	M	Belongs to the NAD(P)-dependent epimerase dehydratase family	galE	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
k59_177870_1	686340.Metal_1012	4.41e-77	246.0	COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,1RN23@1236|Gammaproteobacteria,1XE4R@135618|Methylococcales	135618|Methylococcales	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntA	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N,PNTB_4TM
k59_1679023_1	1090320.KB900605_gene1352	1.25e-24	106.0	COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,2TRWK@28211|Alphaproteobacteria,2K0AK@204457|Sphingomonadales	204457|Sphingomonadales	P	Acts as a magnesium transporter	mgtE	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
k59_289446_1	15368.BRADI5G27490.1	7.05e-68	220.0	COG0154@1|root,KOG1211@2759|Eukaryota,37IP4@33090|Viridiplantae,3G9YA@35493|Streptophyta,3KSHG@4447|Liliopsida,3IBEF@38820|Poales	35493|Streptophyta	J	Amidase	AMI1	GO:0003674,GO:0003824,GO:0004040,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006082,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009683,GO:0009684,GO:0009850,GO:0009851,GO:0009987,GO:0010817,GO:0016053,GO:0016787,GO:0016810,GO:0016811,GO:0018130,GO:0019438,GO:0019752,GO:0031974,GO:0031981,GO:0032787,GO:0034641,GO:0034754,GO:0042430,GO:0042435,GO:0042445,GO:0042446,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043864,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0046483,GO:0065007,GO:0065008,GO:0070013,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
k59_344537_1	1089546.AQUI01000002_gene4240	2.33e-51	185.0	COG3250@1|root,COG3250@2|Bacteria,2GMAT@201174|Actinobacteria,408WF@622450|Actinopolysporales	201174|Actinobacteria	G	Beta galactosidase small chain	-	-	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	Bgal_small_N,DUF4981,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N,Laminin_G_3,NPCBM,NPCBM_assoc
k59_122181_1	795666.MW7_3334	3.56e-57	186.0	COG2085@1|root,COG2085@2|Bacteria,1MXS0@1224|Proteobacteria,2VRQ2@28216|Betaproteobacteria,1K9V6@119060|Burkholderiaceae	28216|Betaproteobacteria	S	NADP oxidoreductase coenzyme F420-dependent	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
k59_1289864_1	1123288.SOV_4c00070	0.00061	48.1	COG1480@1|root,COG1480@2|Bacteria,1TR1A@1239|Firmicutes,4H2Q1@909932|Negativicutes	909932|Negativicutes	S	metal-dependent phosphohydrolase, 7TM intracellular region	-	-	-	ko:K07037	-	-	-	-	ko00000	-	-	-	7TM-7TMR_HD,7TMR-HDED,HD
k59_1679028_1	1048834.TC41_0137	1.56e-34	127.0	COG0235@1|root,COG0235@2|Bacteria,1V8RY@1239|Firmicutes,4I3I8@91061|Bacilli,279GZ@186823|Alicyclobacillaceae	91061|Bacilli	G	PFAM class II aldolase adducin family protein	-	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
k59_622545_1	1382306.JNIM01000001_gene1523	6.52e-88	269.0	COG1136@1|root,COG1136@2|Bacteria,2G5S3@200795|Chloroflexi	200795|Chloroflexi	V	PFAM ABC transporter related	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran
k59_1679032_1	1449050.JNLE01000003_gene2380	0.000147	49.7	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia,36EGZ@31979|Clostridiaceae	186801|Clostridia	C	NADH flavin oxidoreductase NADH oxidase	-	-	-	-	-	-	-	-	-	-	-	-	ADC,Oxidored_FMN,Pyr_redox_2
k59_1178844_1	1151116.Q7S_12790	1.6e-42	154.0	COG0624@1|root,COG0624@2|Bacteria,1MW20@1224|Proteobacteria,1RY5V@1236|Gammaproteobacteria,3FGUV@34037|Rahnella	1236|Gammaproteobacteria	E	Peptidase dimerisation domain	cndP1	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
k59_177885_1	765420.OSCT_0571	6.04e-81	251.0	COG0240@1|root,COG0240@2|Bacteria,2G6HJ@200795|Chloroflexi,376MV@32061|Chloroflexia	32061|Chloroflexia	C	NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain	-	-	1.5.1.28	ko:K04940	-	-	-	-	ko00000,ko01000	-	-	-	NAD_Gly3P_dh_N,Octopine_DH
k59_1067635_1	1294142.CINTURNW_2639	2.97e-51	187.0	COG0383@1|root,COG1470@1|root,COG3291@1|root,COG4733@1|root,COG0383@2|Bacteria,COG1470@2|Bacteria,COG3291@2|Bacteria,COG4733@2|Bacteria,1TQEH@1239|Firmicutes,248VH@186801|Clostridia,36GKJ@31979|Clostridiaceae	186801|Clostridia	G	Glycosyl hydrolases family 38 C-terminal domain	-	-	3.2.1.24	ko:K01191	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04131	-	GH38	-	Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C
k59_1123801_1	861299.J421_0899	1.42e-26	113.0	COG5492@1|root,COG5492@2|Bacteria,1ZSW8@142182|Gemmatimonadetes	2|Bacteria	N	domain, Protein	-	-	3.2.1.4,3.4.17.14	ko:K01179,ko:K07260,ko:K13735	ko00500,ko00550,ko01100,ko01502,ko02020,ko05100,map00500,map00550,map01100,map01502,map02020,map05100	M00651	R06200,R11307,R11308	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	-	GH5,GH9	-	Big_1,Big_2,Glug,IAT_beta,Invasin_D3,LysM,Mfa_like_1,SLH
k59_413476_1	296591.Bpro_4334	1.8e-71	228.0	COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,2VI0E@28216|Betaproteobacteria,4ABVU@80864|Comamonadaceae	28216|Betaproteobacteria	L	Integrase, catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	HTH_38,rve
k59_413479_1	452637.Oter_3351	1.2e-61	209.0	COG1472@1|root,COG1472@2|Bacteria,46TQE@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Fibronectin type III-like domain	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
k59_1191888_1	861299.J421_6044	1.75e-94	293.0	COG2192@1|root,COG2192@2|Bacteria,1ZUTI@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Carbamoyltransferase C-terminus	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
k59_1303207_1	861299.J421_4471	1.17e-69	232.0	COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,1ZT89@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Transketolase, pyrimidine binding domain	-	-	1.2.4.4	ko:K11381	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
k59_134927_1	768671.ThimaDRAFT_4172	8.1e-123	359.0	COG1180@1|root,COG1180@2|Bacteria,1NQC1@1224|Proteobacteria,1T0C6@1236|Gammaproteobacteria,1WXH4@135613|Chromatiales	135613|Chromatiales	C	PFAM Radical SAM	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
k59_524719_1	589873.EP13_14875	1.22e-62	199.0	COG0279@1|root,COG0279@2|Bacteria,1NJ8X@1224|Proteobacteria,1RS1Y@1236|Gammaproteobacteria,466WU@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate	gmhA	-	5.3.1.28	ko:K03271,ko:K12961	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005,ko03036	-	-	-	SIS_2
k59_1249180_1	861299.J421_6359	3.08e-33	132.0	COG0577@1|root,COG0577@2|Bacteria	861299.J421_6359|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_302443_1	443143.GM18_1900	4.17e-73	234.0	COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,42MDB@68525|delta/epsilon subdivisions,2WITV@28221|Deltaproteobacteria,43UES@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
k59_302443_2	243231.GSU0081	2.3e-21	87.0	2CDR8@1|root,32ZSF@2|Bacteria,1NCBG@1224|Proteobacteria,42V4S@68525|delta/epsilon subdivisions,2WSDP@28221|Deltaproteobacteria,43VIE@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_524737_1	1286106.MPL1_01254	4.98e-06	51.2	COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,1RMCY@1236|Gammaproteobacteria,45ZPB@72273|Thiotrichales	72273|Thiotrichales	U	Involved in the TonB-independent uptake of proteins	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
k59_1747051_1	1463854.JOHT01000009_gene1788	2.65e-10	62.8	COG0654@1|root,COG0654@2|Bacteria,2I2TH@201174|Actinobacteria	201174|Actinobacteria	CH	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
k59_1747051_2	1218076.BAYB01000042_gene5660	3.34e-49	166.0	COG0500@1|root,COG2226@2|Bacteria,1RFPW@1224|Proteobacteria,2VRVY@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_1080497_1	1121935.AQXX01000144_gene4419	5.18e-05	45.4	COG0589@1|root,COG0589@2|Bacteria,1RI97@1224|Proteobacteria,1SBPE@1236|Gammaproteobacteria,1XMD7@135619|Oceanospirillales	135619|Oceanospirillales	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_1136873_1	1521187.JPIM01000045_gene1436	4.94e-23	99.4	COG0196@1|root,COG0196@2|Bacteria,2G6JF@200795|Chloroflexi,374TG@32061|Chloroflexia	32061|Chloroflexia	H	TIGRFAM riboflavin biosynthesis protein RibF	-	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
k59_357472_1	1449353.JQMQ01000004_gene6527	7.89e-39	134.0	2EKKQ@1|root,33EAI@2|Bacteria,2H1EK@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_802833_1	148814.JI66_01120	5.76e-33	126.0	COG1940@1|root,COG1940@2|Bacteria,1TPKW@1239|Firmicutes,4HBAU@91061|Bacilli,3F4F0@33958|Lactobacillaceae	91061|Bacilli	G	Glucokinase	glcK	GO:0003674,GO:0003824,GO:0004340,GO:0004396,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019637,GO:0044237,GO:0044238,GO:0044262,GO:0044424,GO:0044464,GO:0046835,GO:0051156,GO:0071704,GO:1901135	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS07790	ROK
k59_79769_1	103690.17135282	6.05e-44	164.0	COG0265@1|root,COG0457@1|root,COG1672@1|root,COG0265@2|Bacteria,COG0457@2|Bacteria,COG1672@2|Bacteria,1GCW9@1117|Cyanobacteria,1HRC5@1161|Nostocales	1117|Cyanobacteria	O	Trypsin-like peptidase domain	-	-	-	-	-	-	-	-	-	-	-	-	TPR_12,Trypsin_2
k59_1136889_1	502025.Hoch_5887	6.43e-32	128.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42RC9@68525|delta/epsilon subdivisions,2WN5U@28221|Deltaproteobacteria,2YWJ8@29|Myxococcales	28221|Deltaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	DUF4388,PEGA,Pkinase
k59_302488_1	1242864.D187_004771	4.24e-09	63.2	COG0613@1|root,COG0613@2|Bacteria	2|Bacteria	Q	PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
k59_1080529_1	1121877.JQKF01000019_gene2575	2.65e-13	69.3	COG1814@1|root,COG1814@2|Bacteria,2GIZ3@201174|Actinobacteria,4CMZV@84992|Acidimicrobiia	84992|Acidimicrobiia	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
k59_302509_2	1123508.JH636440_gene2231	8.01e-08	56.2	COG0394@1|root,COG0394@2|Bacteria,2IX5F@203682|Planctomycetes	203682|Planctomycetes	T	Belongs to the SUA5 family	-	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc,Sua5_yciO_yrdC
k59_1470211_1	479434.Sthe_2691	7.13e-100	311.0	COG1523@1|root,COG1523@2|Bacteria,2G86B@200795|Chloroflexi	200795|Chloroflexi	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
k59_79817_1	1205680.CAKO01000027_gene4745	1.38e-63	209.0	COG0415@1|root,COG0415@2|Bacteria,1RG4D@1224|Proteobacteria	1224|Proteobacteria	L	PFAM DNA photolyase, FAD-binding	phr	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
k59_1358870_1	1206741.BAFX01000104_gene1417	9.66e-53	176.0	COG1136@1|root,COG1136@2|Bacteria,2GJN6@201174|Actinobacteria,4FTWA@85025|Nocardiaceae	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	lolD	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1635463_1	1122604.JONR01000006_gene2654	1.09e-58	198.0	COG4166@1|root,COG4166@2|Bacteria,1P91R@1224|Proteobacteria,1RN57@1236|Gammaproteobacteria,1X48I@135614|Xanthomonadales	135614|Xanthomonadales	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
k59_302524_1	391596.PBAL39_00240	8.28e-40	151.0	COG3250@1|root,COG3250@2|Bacteria,4NF3W@976|Bacteroidetes,1INWH@117747|Sphingobacteriia	976|Bacteroidetes	G	Glycoside hydrolase, family 2, TIM barrel	-	-	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	Bgal_small_N,DUF4981,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N,RicinB_lectin_2
k59_634941_1	1187848.AJYQ01000156_gene3750	3.7e-27	112.0	COG0624@1|root,COG0624@2|Bacteria,1MUSU@1224|Proteobacteria,1RNIW@1236|Gammaproteobacteria,1XUGI@135623|Vibrionales	135623|Vibrionales	E	COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases	-	-	3.4.17.11	ko:K01295	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
k59_970112_1	5888.CAK67086	5.3e-09	61.2	COG0667@1|root,KOG1575@2759|Eukaryota,3ZB1V@5878|Ciliophora	5878|Ciliophora	C	Oxidoreductase, aldo keto reductase family protein	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_634946_2	929562.Emtol_2321	0.000838	41.6	COG0457@1|root,COG0457@2|Bacteria,4NRIH@976|Bacteroidetes,47QEH@768503|Cytophagia	976|Bacteroidetes	S	Protein of unknown function (DUF2911)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2911
k59_1026222_1	390989.JOEG01000016_gene5674	5.36e-09	60.8	COG4292@1|root,COG4292@2|Bacteria,2GJPB@201174|Actinobacteria,4DE0T@85008|Micromonosporales	201174|Actinobacteria	S	Bacterial low temperature requirement A protein (LtrA)	-	-	-	-	-	-	-	-	-	-	-	-	LtrA
k59_1026222_2	649831.L083_5310	8.14e-17	78.2	COG2141@1|root,COG2141@2|Bacteria,2GJRF@201174|Actinobacteria,4DB2G@85008|Micromonosporales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_634953_1	1122135.KB893146_gene1713	1.33e-92	292.0	COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,2TQUZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Belongs to the ClpA ClpB family	clpA	GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043335,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564	-	ko:K03694	-	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_1026242_1	211114.JOEF01000020_gene785	6.56e-15	79.7	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,2GMN4@201174|Actinobacteria,4E2DC@85010|Pseudonocardiales	201174|Actinobacteria	GT	PEP-utilising enzyme, mobile domain	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
k59_802904_1	1380390.JIAT01000016_gene5610	4.25e-19	86.3	COG0135@1|root,COG0135@2|Bacteria,2IHPP@201174|Actinobacteria,4CQBZ@84995|Rubrobacteria	84995|Rubrobacteria	E	Belongs to the TrpF family	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
k59_802904_2	1121935.AQXX01000129_gene1769	1.98e-12	67.4	COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,1RP4D@1236|Gammaproteobacteria,1XHIG@135619|Oceanospirillales	135619|Oceanospirillales	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_747313_1	883126.HMPREF9710_05086	9.26e-25	103.0	COG1028@1|root,COG1028@2|Bacteria,1MUEV@1224|Proteobacteria,2VH8R@28216|Betaproteobacteria,473C7@75682|Oxalobacteraceae	28216|Betaproteobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	phaB	-	1.1.1.36	ko:K00023	ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200	M00373	R01779,R01977	RC00103,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	adh_short,adh_short_C2
k59_470372_1	765420.OSCT_1743	6.37e-23	100.0	COG0845@1|root,COG1566@1|root,COG0845@2|Bacteria,COG1566@2|Bacteria,2G8X1@200795|Chloroflexi,376RT@32061|Chloroflexia	32061|Chloroflexia	M	PFAM secretion protein HlyD family protein	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3
k59_246516_1	3218.PP1S260_4V6.1	3.49e-14	76.6	KOG0118@1|root,KOG0118@2759|Eukaryota,37KEX@33090|Viridiplantae,3GES4@35493|Streptophyta	35493|Streptophyta	A	kDa ribonucleoprotein	-	-	-	ko:K11294	ko05130,map05130	-	-	-	ko00000,ko00001,ko03009,ko03036	-	-	-	RRM_1
k59_524860_1	477974.Daud_2046	3.95e-09	58.2	COG0295@1|root,COG0319@1|root,COG0295@2|Bacteria,COG0319@2|Bacteria,1V6BU@1239|Firmicutes,24MQZ@186801|Clostridia,2620D@186807|Peptococcaceae	186801|Clostridia	J	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	3.5.4.5	ko:K01489,ko:K07042	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000,ko03009	-	-	-	UPF0054
k59_524860_2	365046.Rta_31170	1.31e-17	81.6	COG2928@1|root,COG2928@2|Bacteria,1MWT5@1224|Proteobacteria,2VH65@28216|Betaproteobacteria,4AB4A@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF502)	-	-	-	-	-	-	-	-	-	-	-	-	DUF502
k59_302585_1	658655.HMPREF0988_02499	2.12e-151	431.0	COG1912@1|root,COG1912@2|Bacteria,1TSR3@1239|Firmicutes,24D3T@186801|Clostridia,27JTP@186928|unclassified Lachnospiraceae	186801|Clostridia	S	S-adenosyl-l-methionine hydroxide adenosyltransferase	-	-	-	ko:K22205	-	-	-	-	ko00000,ko01000	-	-	-	SAM_adeno_trans
k59_302585_2	1280680.AUJU01000004_gene1057	2.97e-18	83.2	COG0619@1|root,COG0619@2|Bacteria,1TPMV@1239|Firmicutes,24AYK@186801|Clostridia,4BX4Q@830|Butyrivibrio	186801|Clostridia	P	Cobalt transport protein	-	-	-	ko:K16785	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	CbiQ
k59_302589_1	207954.MED92_17728	2.79e-15	75.1	COG1622@1|root,COG1622@2|Bacteria,1MWHZ@1224|Proteobacteria,1RP4H@1236|Gammaproteobacteria,1XIU7@135619|Oceanospirillales	135619|Oceanospirillales	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	coxB	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrome_CBB3
k59_24656_1	1121933.AUHH01000003_gene1388	1.81e-41	146.0	COG0202@1|root,COG0202@2|Bacteria,2GJJ5@201174|Actinobacteria,4DNW6@85009|Propionibacteriales	201174|Actinobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030312,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
k59_24656_2	106370.Francci3_0609	3.43e-13	68.9	COG0522@1|root,COG0522@2|Bacteria,2GIRX@201174|Actinobacteria,4EREE@85013|Frankiales	201174|Actinobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0016020,GO:0019222,GO:0019843,GO:0030312,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
k59_1527079_2	953739.SVEN_3727	1.99e-73	229.0	COG1131@1|root,COG1131@2|Bacteria,2GK1W@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_359241_1	1313304.CALK_0105	8.57e-82	260.0	COG1048@1|root,COG1048@2|Bacteria	2|Bacteria	C	aconitate hydratase activity	dmdA	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2763	Aconitase,Aconitase_C
k59_636750_1	690850.Desaf_3349	3.84e-07	58.2	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2M8VA@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K02481,ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1028163_1	561175.KB894096_gene773	2.15e-135	402.0	COG0365@1|root,COG0365@2|Bacteria,2GP7N@201174|Actinobacteria,4EIBH@85012|Streptosporangiales	201174|Actinobacteria	I	Acetyl-coenzyme A synthetase N-terminus	prpE	-	6.2.1.17	ko:K01908	ko00640,ko01100,map00640,map01100	-	R00926,R01354	RC00004,RC00043,RC00070,RC02816	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_1193739_1	1532557.JL37_23315	3.26e-47	169.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2VH0Y@28216|Betaproteobacteria,3T2AW@506|Alcaligenaceae	28216|Betaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	1.1.1.35,4.2.1.17,5.1.2.3	ko:K01782,ko:K07516	ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04743,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
k59_1582882_1	4098.XP_009605210.1	1.74e-07	55.8	COG0160@1|root,KOG1404@2759|Eukaryota,37HV3@33090|Viridiplantae,3GGGM@35493|Streptophyta,44R6B@71274|asterids	35493|Streptophyta	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.40,2.6.1.44	ko:K00827	ko00250,ko00260,ko00270,ko00280,ko01100,ko01110,map00250,map00260,map00270,map00280,map01100,map01110	-	R00369,R00372,R02050,R10992	RC00006,RC00008,RC00018,RC00160	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_3
k59_136815_1	1128421.JAGA01000001_gene2056	2.31e-46	166.0	COG5002@1|root,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	lisK	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
k59_359282_1	1340434.AXVA01000005_gene4459	1.27e-26	110.0	COG1477@1|root,COG1477@2|Bacteria,1TR9C@1239|Firmicutes,4HHVC@91061|Bacilli,1ZIP6@1386|Bacillus	91061|Bacilli	H	ApbE family	apbE	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
k59_1415904_1	234267.Acid_7789	1.33e-21	100.0	COG1450@1|root,COG1450@2|Bacteria	2|Bacteria	NU	protein transport across the cell outer membrane	gspD	-	-	ko:K02453,ko:K03219	ko03070,ko05111,map03070,map05111	M00331,M00332,M00542	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15,3.A.6.1,3.A.6.3	-	-	Secretin,Secretin_N
k59_1082470_1	290397.Adeh_2160	3.82e-76	241.0	COG3642@1|root,COG3642@2|Bacteria,1R9NI@1224|Proteobacteria,43BZ9@68525|delta/epsilon subdivisions,2X7A0@28221|Deltaproteobacteria,2YYM9@29|Myxococcales	28221|Deltaproteobacteria	T	Domain of unknown function (DUF4032)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4032,Kdo
k59_415390_1	1286171.EAL2_c17510	4.17e-11	62.4	COG0459@1|root,COG0459@2|Bacteria,1TP1T@1239|Firmicutes,248BG@186801|Clostridia,25V1N@186806|Eubacteriaceae	186801|Clostridia	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
k59_415390_2	91464.S7335_4796	1.4e-34	121.0	COG0234@1|root,COG0234@2|Bacteria,1G6J1@1117|Cyanobacteria,1H0Y8@1129|Synechococcus	1117|Cyanobacteria	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
k59_636789_1	326427.Cagg_2869	1.82e-06	49.3	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	ko:K17285	-	-	-	-	ko00000,ko04147	-	-	-	SBP56
k59_636789_2	865938.Weevi_1119	5.7e-08	56.2	COG0370@1|root,COG0370@2|Bacteria,4NEII@976|Bacteroidetes,1HXDK@117743|Flavobacteriia	976|Bacteroidetes	P	transporter of a GTP-driven Fe(2 ) uptake system	feoB	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoA,FeoB_C,FeoB_N,Gate
k59_1527132_1	331869.BAL199_22702	9.25e-94	286.0	COG3385@1|root,COG3385@2|Bacteria,1QURV@1224|Proteobacteria,2TW56@28211|Alphaproteobacteria,4BSI7@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	L	COG2183 Transcriptional accessory protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k59_636813_1	1128421.JAGA01000003_gene3536	5.78e-57	192.0	COG5002@1|root,COG5002@2|Bacteria,2NS5D@2323|unclassified Bacteria	2|Bacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	2.7.13.3	ko:K02484,ko:K07642	ko02020,map02020	M00450,M00645,M00646,M00648	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
k59_1472161_1	391596.PBAL39_07255	1.31e-66	216.0	COG4952@1|root,COG4952@2|Bacteria,4NFWW@976|Bacteroidetes,1INU9@117747|Sphingobacteriia	976|Bacteroidetes	M	Sugar isomerase	-	-	5.3.1.14	ko:K01820	ko00040,ko00051,ko01120,map00040,map00051,map01120	-	R01906,R02437,R06589	RC00376,RC00434,RC00516	ko00000,ko00001,ko01000	-	-	-	-
k59_931812_2	671143.DAMO_0610	6.78e-64	199.0	COG0494@1|root,COG0494@2|Bacteria,2NPTC@2323|unclassified Bacteria	2|Bacteria	L	NUDIX domain	nudF	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
k59_1539564_1	251229.Chro_2996	1.21e-90	273.0	COG1741@1|root,COG1741@2|Bacteria,1G0UH@1117|Cyanobacteria,3VJ25@52604|Pleurocapsales	1117|Cyanobacteria	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin
k59_1485668_2	1385517.N800_00955	1.59e-67	214.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,1RN6J@1236|Gammaproteobacteria,1X393@135614|Xanthomonadales	135614|Xanthomonadales	E	Belongs to the cysteine synthase cystathionine beta- synthase family	-	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_817615_1	314287.GB2207_00170	2.62e-62	215.0	COG0404@1|root,COG0446@1|root,COG0404@2|Bacteria,COG0446@2|Bacteria,1MVEK@1224|Proteobacteria,1RQKR@1236|Gammaproteobacteria,1J939@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Sarcosine oxidase, gamma subunit family	-	-	1.5.3.1	ko:K00302	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	Fer2_4,GCV_T,GCV_T_C,Pyr_redox_2
k59_1761091_1	272123.Anacy_1299	1.02e-36	143.0	COG0318@1|root,COG3321@1|root,COG4221@1|root,COG0318@2|Bacteria,COG3321@2|Bacteria,COG4221@2|Bacteria,1FZXE@1117|Cyanobacteria,1HJCN@1161|Nostocales	1117|Cyanobacteria	IQ	Acyl transferase domain in polyketide synthase (PKS) enzymes.	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2,AMP-binding,Acyl_transf_1,Aminotran_1_2,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt
k59_38568_1	391037.Sare_0120	2.42e-66	225.0	COG0542@1|root,COG0542@2|Bacteria,2GJ73@201174|Actinobacteria,4DAJ3@85008|Micromonosporales	201174|Actinobacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695,ko:K03696	ko01100,ko04213,map01100,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_594727_1	931627.MycrhDRAFT_5437	1.64e-54	186.0	COG0451@1|root,COG0451@2|Bacteria,2GN2J@201174|Actinobacteria,2332V@1762|Mycobacteriaceae	201174|Actinobacteria	M	epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase,NAD_binding_10
k59_318686_1	926569.ANT_05520	1.86e-61	203.0	COG1363@1|root,COG1363@2|Bacteria,2G5WS@200795|Chloroflexi	200795|Chloroflexi	G	peptidase M42 family protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
k59_318699_1	1283300.ATXB01000001_gene385	2.51e-11	65.1	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,1RMHY@1236|Gammaproteobacteria,1XEIK@135618|Methylococcales	135618|Methylococcales	KT	PFAM RNA polymerase sigma factor 54, interaction	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS_4,Sigma54_activat
k59_1596729_1	391615.ABSJ01000055_gene1354	6.37e-76	239.0	COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,1RNEW@1236|Gammaproteobacteria,1J4X6@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046033,GO:0046040,GO:0046085,GO:0046086,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	iECNA114_1301.ECNA114_4393,iECSF_1327.ECSF_4063,iJN746.PP_4889	Adenylsucc_synt
k59_649061_1	366649.XFF4834R_chr42170	9.83e-50	182.0	COG2931@1|root,COG3468@1|root,COG4625@1|root,COG2931@2|Bacteria,COG3468@2|Bacteria,COG4625@2|Bacteria,1MU7T@1224|Proteobacteria,1T45Q@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	Domains in Na-Ca exchangers and integrin-beta4	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta
k59_1709111_1	56780.SYN_00266	1.26e-41	151.0	COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,42M5U@68525|delta/epsilon subdivisions,2WJ06@28221|Deltaproteobacteria,2MQ54@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	TIGRFAM molybdenum cofactor synthesis domain	-	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
k59_649072_1	330214.NIDE1131	3.43e-89	285.0	COG1452@1|root,COG1452@2|Bacteria	2|Bacteria	M	lipopolysaccharide transport	-	-	-	ko:K22110	-	-	-	-	ko00000,ko02000	1.B.35.1,1.B.35.2	-	-	Glyco_hydro_63
k59_1761135_1	290397.Adeh_2968	2.31e-86	285.0	COG4770@1|root,COG4799@1|root,COG4770@2|Bacteria,COG4799@2|Bacteria,1P6RE@1224|Proteobacteria,43A2M@68525|delta/epsilon subdivisions,2X1XW@28221|Deltaproteobacteria,2YX2T@29|Myxococcales	28221|Deltaproteobacteria	I	Acetyl-CoA carboxylase, central region	-	-	-	-	-	-	-	-	-	-	-	-	ACC_central,Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,Carboxyl_trans
k59_707859_1	1379270.AUXF01000001_gene1993	3.99e-26	107.0	COG4447@1|root,COG4447@2|Bacteria,1ZUES@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Sortilin, neurotensin receptor 3,	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
k59_539695_1	290397.Adeh_2406	1.21e-45	168.0	COG0493@1|root,COG1145@1|root,COG0493@2|Bacteria,COG1145@2|Bacteria,1MU2H@1224|Proteobacteria,42MGY@68525|delta/epsilon subdivisions,2WKB4@28221|Deltaproteobacteria,2YTUD@29|Myxococcales	28221|Deltaproteobacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4,Fer4_20,Pyr_redox_2
k59_649095_1	1535422.ND16A_3386	3.81e-59	187.0	COG3043@1|root,COG3043@2|Bacteria,1RHGD@1224|Proteobacteria,1S84V@1236|Gammaproteobacteria,2Q6XD@267889|Colwelliaceae	1236|Gammaproteobacteria	C	Electron transfer subunit of the periplasmic nitrate reductase complex NapAB	napB	GO:0006091,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0044237,GO:0045333,GO:0055114	-	ko:K02568	ko00910,ko01120,map00910,map01120	M00529,M00530	R00798	RC02812	ko00000,ko00001,ko00002	-	-	iAF1260.b2203,iBWG_1329.BWG_1976,iE2348C_1286.E2348C_2347,iECDH10B_1368.ECDH10B_2360,iECDH1ME8569_1439.ECDH1ME8569_2138,iECED1_1282.ECED1_2668,iECH74115_1262.ECH74115_3340,iECIAI39_1322.ECIAI39_2341,iECNA114_1301.ECNA114_2295,iECOK1_1307.ECOK1_2437,iECP_1309.ECP_2244,iECS88_1305.ECS88_2350,iECSF_1327.ECSF_2084,iECSP_1301.ECSP_3082,iECUMN_1333.ECUMN_2538,iETEC_1333.ETEC_2337,iEcDH1_1363.EcDH1_1456,iEcolC_1368.EcolC_1447,iG2583_1286.G2583_2744,iJO1366.b2203,iLF82_1304.LF82_1453,iNRG857_1313.NRG857_11180,iSFV_1184.SFV_2279,iSF_1195.SF2287,iSFxv_1172.SFxv_2521,iS_1188.S2417,iUMN146_1321.UM146_05790,iY75_1357.Y75_RS11525	NapB
k59_649095_2	1123366.TH3_09230	4.18e-34	122.0	COG3005@1|root,COG3005@2|Bacteria,1MWV2@1224|Proteobacteria,2TURW@28211|Alphaproteobacteria,2JPFC@204441|Rhodospirillales	204441|Rhodospirillales	C	Cytochrome c-type protein	-	-	-	ko:K02569	-	-	-	-	ko00000	-	-	-	Cytochrom_NNT
k59_1265003_1	926562.Oweho_1053	2.92e-68	224.0	COG1164@1|root,COG1164@2|Bacteria,4NJFW@976|Bacteroidetes,1I88A@117743|Flavobacteriia	976|Bacteroidetes	E	Angiotensin-converting enzyme	-	-	3.4.15.1	ko:K01283	ko04614,ko04924,ko05142,ko05410,map04614,map04924,map05142,map05410	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	Peptidase_M2
k59_1649803_1	1121035.AUCH01000002_gene1460	1.54e-23	99.0	COG2265@1|root,COG2265@2|Bacteria,1QV4X@1224|Proteobacteria,2WGYG@28216|Betaproteobacteria,2KX4K@206389|Rhodocyclales	206389|Rhodocyclales	J	Thiopurine S-methyltransferase (TPMT)	-	-	2.1.1.67	ko:K00569	ko00983,map00983	-	R08236,R08239,R08246	RC00003,RC00980,RC02277	ko00000,ko00001,ko01000	-	-	-	TPMT
k59_931912_1	29306.JOBE01000012_gene6478	6.7e-93	292.0	COG0444@1|root,COG1173@1|root,COG0444@2|Bacteria,COG1173@2|Bacteria,2GIXV@201174|Actinobacteria	201174|Actinobacteria	EP	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,BPD_transp_1,OppC_N,oligo_HPY
k59_1429295_1	42256.RradSPS_2735	2.4e-18	86.3	COG1164@1|root,COG1164@2|Bacteria,2HDPQ@201174|Actinobacteria,4CTTS@84995|Rubrobacteria	84995|Rubrobacteria	E	Oligoendopeptidase f	-	-	3.4.15.1	ko:K01283	ko04614,ko04924,ko05142,ko05410,map04614,map04924,map05142,map05410	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	Peptidase_M2
k59_872746_2	316274.Haur_4497	5.69e-26	102.0	COG0491@1|root,COG0491@2|Bacteria,2G8K6@200795|Chloroflexi,377BH@32061|Chloroflexia	32061|Chloroflexia	S	PFAM beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_1649824_1	1111454.HMPREF1250_1608	1.15e-11	70.1	COG0465@1|root,COG0465@2|Bacteria,1TPTV@1239|Firmicutes,4H2PQ@909932|Negativicutes	909932|Negativicutes	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_1429320_1	1286631.X805_36920	8.83e-107	324.0	COG1021@1|root,COG1021@2|Bacteria,1NSN8@1224|Proteobacteria,2WGU9@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
k59_94979_2	1137799.GZ78_26100	2.15e-29	121.0	COG0591@1|root,COG0591@2|Bacteria,1MUBI@1224|Proteobacteria,1T3SF@1236|Gammaproteobacteria,1XP4Q@135619|Oceanospirillales	135619|Oceanospirillales	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
k59_318791_1	1304878.AUGD01000001_gene195	1.41e-80	248.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,3K066@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110
k59_38672_1	91464.S7335_2253	1.19e-07	53.9	COG1073@1|root,COG1073@2|Bacteria,1G1YP@1117|Cyanobacteria,1H0WW@1129|Synechococcus	1117|Cyanobacteria	S	R COG1073 Hydrolases of the alpha beta superfamily	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4
k59_38672_2	15368.BRADI1G57470.1	2.54e-20	91.7	COG1957@1|root,KOG2938@2759|Eukaryota,37HXM@33090|Viridiplantae,3GC13@35493|Streptophyta,3KNC3@4447|Liliopsida,3ICAB@38820|Poales	35493|Streptophyta	F	Inosine-uridine preferring nucleoside hydrolase	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006148,GO:0006152,GO:0006725,GO:0006807,GO:0007275,GO:0007568,GO:0008150,GO:0008152,GO:0008194,GO:0008477,GO:0009056,GO:0009116,GO:0009119,GO:0009164,GO:0009987,GO:0010150,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0016798,GO:0016799,GO:0019439,GO:0032501,GO:0032502,GO:0034641,GO:0034655,GO:0034656,GO:0035251,GO:0042278,GO:0042454,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046102,GO:0046128,GO:0046130,GO:0046483,GO:0046527,GO:0046700,GO:0047724,GO:0048366,GO:0048367,GO:0048731,GO:0048827,GO:0048856,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0090693,GO:0099402,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901657,GO:1901658	3.2.2.3	ko:K01240	ko00240,ko00760,map00240,map00760	-	R01080,R01273,R10046	RC00033,RC00063,RC00318,RC00485	ko00000,ko00001,ko01000	-	-	-	IU_nuc_hydro
k59_1596824_1	1123517.JOMR01000001_gene1183	2.36e-40	152.0	COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,462HB@72273|Thiotrichales	72273|Thiotrichales	P	Sodium:sulfate symporter transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,TrkA_C
k59_931966_1	926569.ANT_02630	3.03e-65	208.0	COG0226@1|root,COG0226@2|Bacteria,2G7T2@200795|Chloroflexi	200795|Chloroflexi	P	TIGRFAM phosphate binding protein	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
k59_931966_2	518766.Rmar_1826	5.39e-05	45.1	COG1117@1|root,COG1117@2|Bacteria,4NFAB@976|Bacteroidetes,1FJ3J@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
k59_872779_1	1223545.GS4_08_02480	2.14e-36	133.0	COG0789@1|root,COG0789@2|Bacteria,2H5GI@201174|Actinobacteria,4GA4U@85026|Gordoniaceae	201174|Actinobacteria	K	TipAS antibiotic-recognition domain	tipA	-	-	ko:K21744	-	-	-	-	ko00000,ko03000	-	-	-	MerR,MerR-DNA-bind,MerR_1,TipAS
k59_539754_1	102129.Lepto7375DRAFT_4237	4.43e-55	176.0	COG3415@1|root,COG3415@2|Bacteria,1GFZ6@1117|Cyanobacteria	1117|Cyanobacteria	L	Winged helix-turn helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32
k59_372958_1	118161.KB235922_gene2208	6.24e-08	58.9	COG0001@1|root,COG0318@1|root,COG3321@1|root,COG0001@2|Bacteria,COG0318@2|Bacteria,COG3321@2|Bacteria,1FZXE@1117|Cyanobacteria,3VI4P@52604|Pleurocapsales	1117|Cyanobacteria	Q	Beta-ketoacyl synthase, C-terminal domain	-	-	-	ko:K16129	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,Acyl_transf_1,Aminotran_3,Bac_luciferase,Condensation,KAsynt_C_assoc,Ketoacyl-synt_C,Methyltransf_12,PP-binding,ketoacyl-synt
k59_539755_2	656024.FsymDg_3452	1.17e-37	139.0	COG2304@1|root,COG2304@2|Bacteria,2GJRP@201174|Actinobacteria	201174|Actinobacteria	S	tyrosinase	-	-	1.14.18.1	ko:K00505	ko00350,ko00950,ko00965,ko01100,ko01110,ko04916,map00350,map00950,map00965,map01100,map01110,map04916	M00042	R00731,R02078,R02363,R02383,R04693,R04884	RC00046,RC00150,RC00180	ko00000,ko00001,ko00002,ko01000	-	-	-	Tyrosinase
k59_38694_1	670487.Ocepr_2216	3.81e-74	242.0	COG3158@1|root,COG3158@2|Bacteria	2|Bacteria	P	potassium ion transmembrane transporter activity	kup	GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015672,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0098655,GO:0098660,GO:0098662	-	ko:K03549	-	-	-	-	ko00000,ko02000	2.A.72	-	-	K_trans
k59_649175_1	861299.J421_1048	6.48e-21	96.7	COG2091@1|root,COG2091@2|Bacteria	2|Bacteria	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
k59_1485827_1	1089545.KB913037_gene8249	2.28e-37	137.0	COG4447@1|root,COG4447@2|Bacteria,2H2V0@201174|Actinobacteria,4E90H@85010|Pseudonocardiales	201174|Actinobacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1374567_1	56780.SYN_02271	1.26e-74	234.0	COG1683@1|root,COG3272@1|root,COG1683@2|Bacteria,COG3272@2|Bacteria,1MXYZ@1224|Proteobacteria,42M4E@68525|delta/epsilon subdivisions,2WKFT@28221|Deltaproteobacteria,2MQ5J@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1722)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1722,DUF523
k59_1761234_1	47763.JNZA01000045_gene5609	7.01e-12	71.2	COG2909@1|root,COG2909@2|Bacteria,2GJIA@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE,TPR_12
k59_1320786_1	338963.Pcar_2794	1.09e-26	113.0	COG0038@1|root,COG0517@1|root,COG0038@2|Bacteria,COG0517@2|Bacteria,1MV4K@1224|Proteobacteria,42PJQ@68525|delta/epsilon subdivisions,2WKR4@28221|Deltaproteobacteria,43S1M@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Voltage gated chloride channel	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	iAF987.Gmet_3470	CBS,Voltage_CLC
k59_261750_1	66429.JOFL01000031_gene5373	8.67e-38	142.0	COG1249@1|root,COG1249@2|Bacteria,2GIXY@201174|Actinobacteria	201174|Actinobacteria	C	Dehydrogenase	pdhD	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_987332_1	1245469.S58_04020	1.1e-24	99.8	COG5429@1|root,COG5429@2|Bacteria,1MW6R@1224|Proteobacteria,2U33F@28211|Alphaproteobacteria,3JVYD@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1223)	MA20_43790	-	-	-	-	-	-	-	-	-	-	-	DUF1223
k59_987332_2	1120792.JAFV01000001_gene2566	1.97e-29	116.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,2TT3T@28211|Alphaproteobacteria,36X3R@31993|Methylocystaceae	28211|Alphaproteobacteria	C	Aconitase family (aconitate hydratase)	acnA	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0045333,GO:0046459,GO:0047456,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:1901363	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k59_933049_1	926569.ANT_07670	4.02e-30	122.0	COG0845@1|root,COG0845@2|Bacteria,2G6RK@200795|Chloroflexi	200795|Chloroflexi	M	PFAM secretion protein HlyD family protein	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
k59_1097447_2	1122135.KB893170_gene2733	4.31e-05	46.6	COG0733@1|root,COG0733@2|Bacteria,1MUZJ@1224|Proteobacteria,2TUE5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family	-	-	-	ko:K03308	-	-	-	-	ko00000	2.A.22.4,2.A.22.5	-	-	SNF
k59_374065_2	1380384.JADN01000007_gene1632	6.74e-60	205.0	COG1629@1|root,COG1629@2|Bacteria,4PM06@976|Bacteroidetes,1IJK3@117743|Flavobacteriia	976|Bacteroidetes	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
k59_709050_1	290400.Jann_1461	2.62e-05	45.4	COG0673@1|root,COG0673@2|Bacteria,1N0VK@1224|Proteobacteria,2TR13@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_709050_2	1123248.KB893318_gene4112	1.02e-25	105.0	COG0363@1|root,COG0363@2|Bacteria,4NPBJ@976|Bacteroidetes,1IWTJ@117747|Sphingobacteriia	976|Bacteroidetes	G	Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase	-	-	3.5.99.6	ko:K02080,ko:K02564	ko00052,ko00520,ko01100,map00052,map00520,map01100	-	R00765,R08365	RC00163	ko00000,ko00001,ko01000	-	-	-	Glucosamine_iso
k59_1597879_1	1151118.KB895789_gene987	1.61e-26	102.0	COG0346@1|root,COG0346@2|Bacteria,2IRQX@201174|Actinobacteria	201174|Actinobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
k59_650228_1	1121440.AUMA01000022_gene2037	5.45e-59	199.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,42M9N@68525|delta/epsilon subdivisions,2WIZR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	PFAM TRAP C4-dicarboxylate transport system permease DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_818850_1	1121403.AUCV01000015_gene4710	6.63e-13	69.3	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PVE@68525|delta/epsilon subdivisions,2WK31@28221|Deltaproteobacteria,2MPRN@213118|Desulfobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
k59_319896_1	1297742.A176_05941	1.64e-55	189.0	COG0160@1|root,COG0160@2|Bacteria,1MWY6@1224|Proteobacteria,42MB7@68525|delta/epsilon subdivisions,2WJVU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.19	ko:K00823	ko00250,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_650234_1	1150600.ADIARSV_3699	3.33e-78	254.0	COG1009@1|root,COG1009@2|Bacteria,4NEBM@976|Bacteroidetes,1IQ9D@117747|Sphingobacteriia	976|Bacteroidetes	CP	COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter MnhA subunit	nuoL	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_C,Proton_antipo_M,Proton_antipo_N
k59_818861_1	755732.Fluta_2380	7.38e-05	50.8	COG2972@1|root,COG3292@1|root,COG2972@2|Bacteria,COG3292@2|Bacteria,4NFZB@976|Bacteroidetes,1HX37@117743|Flavobacteriia,2PBHB@246874|Cryomorphaceae	976|Bacteroidetes	T	Y_Y_Y domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,His_kinase,Reg_prop,Y_Y_Y
k59_96113_1	926569.ANT_25090	1.09e-31	125.0	COG4942@1|root,COG4942@2|Bacteria,2G960@200795|Chloroflexi	200795|Chloroflexi	D	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_540753_1	500632.CLONEX_02914	1.02e-09	59.7	2CNEN@1|root,32SGY@2|Bacteria,1VDTI@1239|Firmicutes,24N78@186801|Clostridia	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	DUF2752
k59_374110_1	247490.KSU1_C0546	2.67e-37	144.0	COG1409@1|root,COG3204@1|root,COG1409@2|Bacteria,COG3204@2|Bacteria	2|Bacteria	L	pilus organization	-	-	-	ko:K02674,ko:K07004	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Exo_endo_phos,HemolysinCabind,LTD,Laminin_G_3,Metallophos,Pur_ac_phosph_N
k59_429516_1	1234364.AMSF01000065_gene2281	1.84e-07	56.6	COG1807@1|root,COG1807@2|Bacteria,1NMIZ@1224|Proteobacteria,1S48Z@1236|Gammaproteobacteria,1X3YW@135614|Xanthomonadales	135614|Xanthomonadales	M	COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
k59_540759_1	1380390.JIAT01000012_gene3300	1.24e-06	55.1	COG3547@1|root,COG3547@2|Bacteria	2|Bacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1266246_1	1117647.M5M_11955	4.06e-07	52.8	COG0784@1|root,COG3710@1|root,COG0784@2|Bacteria,COG3710@2|Bacteria,1QVVG@1224|Proteobacteria,1S4NY@1236|Gammaproteobacteria,1JATE@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	KT	COG3710 DNA-binding winged-HTH domains	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
k59_987402_1	945713.IALB_0608	7.12e-58	199.0	COG3591@1|root,COG3591@2|Bacteria	2|Bacteria	E	Belongs to the peptidase S1B family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S46
k59_487341_1	309807.SRU_2821	5.02e-13	72.4	COG4805@1|root,COG4805@2|Bacteria,4NFAK@976|Bacteroidetes,1FKD5@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
k59_1065745_2	573413.Spirs_1141	7.58e-09	55.8	COG1826@1|root,COG1826@2|Bacteria	2|Bacteria	U	protein secretion	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
k59_232070_1	224914.BMEI0890	1.69e-89	273.0	COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,2TR87@28211|Alphaproteobacteria,1J2PV@118882|Brucellaceae	28211|Alphaproteobacteria	F	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
k59_732567_1	926569.ANT_16350	6.62e-92	287.0	COG0449@1|root,COG0449@2|Bacteria,2G5T5@200795|Chloroflexi	200795|Chloroflexi	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
k59_1399308_1	1408428.JNJP01000074_gene739	2.06e-10	57.4	COG4577@1|root,COG4577@2|Bacteria,1RH1U@1224|Proteobacteria,42UCN@68525|delta/epsilon subdivisions,2WQ3V@28221|Deltaproteobacteria,2MFZE@213115|Desulfovibrionales	28221|Deltaproteobacteria	CQ	BMC domain	-	-	-	ko:K04027	-	-	-	-	ko00000	-	-	-	BMC
k59_1399308_2	118166.JH976537_gene3815	4.61e-39	137.0	COG4577@1|root,COG4577@2|Bacteria,1G0GA@1117|Cyanobacteria,1H73J@1150|Oscillatoriales	1117|Cyanobacteria	CQ	PFAM BMC domain	-	-	-	-	-	-	-	-	-	-	-	-	BMC
k59_342803_1	1267534.KB906754_gene2805	2.18e-25	109.0	COG0577@1|root,COG0577@2|Bacteria,3Y3Z1@57723|Acidobacteria,2JKRB@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_1343629_1	1173264.KI913949_gene1024	2.16e-48	177.0	COG0642@1|root,COG2202@1|root,COG2203@1|root,COG2905@1|root,COG2964@1|root,COG4251@1|root,COG5002@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG2905@2|Bacteria,COG2964@2|Bacteria,COG4251@2|Bacteria,COG5002@2|Bacteria,1G09B@1117|Cyanobacteria,1H71H@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	CBS,GAF,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
k59_232084_2	694430.Natoc_0734	6.26e-17	74.3	arCOG06266@1|root,arCOG06266@2157|Archaea,2Y0SP@28890|Euryarchaeota,23XG6@183963|Halobacteria	183963|Halobacteria	Q	enzyme of phenylacetate metabolism	-	-	-	-	-	-	-	-	-	-	-	-	PaaB
k59_1121845_1	91464.S7335_5197	2.73e-07	52.8	COG0451@1|root,COG0451@2|Bacteria,1G02N@1117|Cyanobacteria,1GZDS@1129|Synechococcus	1117|Cyanobacteria	GM	Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction	fcl	-	1.1.1.271	ko:K02377	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R05692	RC01014	ko00000,ko00001,ko01000	-	-	-	Epimerase
k59_1121845_2	118173.KB235914_gene1903	5.13e-53	185.0	COG1089@1|root,COG1089@2|Bacteria,1G0M4@1117|Cyanobacteria,1H6XT@1150|Oscillatoriales	1117|Cyanobacteria	M	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose	gmd	-	4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R00888	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
k59_954548_1	1150626.PHAMO_290062	2.6e-23	103.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,2JQ4H@204441|Rhodospirillales	204441|Rhodospirillales	T	signal transduction protein containing a membrane domain, an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_7,PAS_9,dCache_1,dCache_2
k59_1455354_1	926569.ANT_14030	1.32e-54	188.0	COG0480@1|root,COG0480@2|Bacteria,2G680@200795|Chloroflexi	200795|Chloroflexi	J	elongation factor Tu domain 2 protein	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_1621415_1	398527.Bphyt_1049	0.000103	50.1	COG0657@1|root,COG0657@2|Bacteria,1N2XW@1224|Proteobacteria,2VIBB@28216|Betaproteobacteria,1K23I@119060|Burkholderiaceae	28216|Betaproteobacteria	I	PFAM Alpha beta hydrolase fold-3 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
k59_176199_1	195253.Syn6312_1468	2.32e-32	126.0	COG0621@1|root,COG0621@2|Bacteria,1G0BT@1117|Cyanobacteria,1GZ86@1129|Synechococcus	1117|Cyanobacteria	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
k59_9728_1	1120792.JAFV01000001_gene2566	3.28e-80	263.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,2TT3T@28211|Alphaproteobacteria,36X3R@31993|Methylocystaceae	28211|Alphaproteobacteria	C	Aconitase family (aconitate hydratase)	acnA	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0045333,GO:0046459,GO:0047456,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:1901363	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k59_1621420_2	1121946.AUAX01000010_gene3773	1.8e-21	91.3	COG4270@1|root,COG4270@2|Bacteria,2IRGG@201174|Actinobacteria,4DEV2@85008|Micromonosporales	201174|Actinobacteria	S	DoxX-like family	-	-	-	-	-	-	-	-	-	-	-	-	DoxX,DoxX_2
k59_1732865_1	153721.MYP_2422	2.24e-31	124.0	COG0438@1|root,COG0438@2|Bacteria,4NDUY@976|Bacteroidetes	976|Bacteroidetes	M	Glycosyl transferases group 1	-	-	2.4.1.245	ko:K13057	ko00500,ko01100,map00500,map01100	-	R08946,R10525,R11306	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000	-	GT4	-	Glycos_transf_1
k59_1566216_1	469378.Ccur_07460	1.34e-71	231.0	COG1418@1|root,COG4372@1|root,COG1418@2|Bacteria,COG4372@2|Bacteria,2I9DW@201174|Actinobacteria,4CURU@84998|Coriobacteriia	84998|Coriobacteriia	NU	Endoribonuclease that initiates mRNA decay	rny	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
k59_9733_1	1189619.pgond44_14073	3.5e-17	86.7	COG0642@1|root,COG4191@1|root,COG2205@2|Bacteria,COG4191@2|Bacteria,4NEJX@976|Bacteroidetes,1I0JH@117743|Flavobacteriia	976|Bacteroidetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,HATPase_c,HisKA,TPR_12,TPR_7
k59_1233732_1	1144275.COCOR_01794	1.04e-19	93.2	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,2YXGU@29|Myxococcales	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_565229_1	1123278.KB893583_gene1187	3.92e-10	60.5	2DPXN@1|root,333U2@2|Bacteria,4NWCD@976|Bacteroidetes,47SBV@768503|Cytophagia	976|Bacteroidetes	S	2TM domain	-	-	-	-	-	-	-	-	-	-	-	-	2TM
k59_565229_2	468556.AQYG01000048_gene594	5.99e-29	105.0	COG5646@1|root,COG5646@2|Bacteria	2|Bacteria	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
k59_1510627_1	880073.Calab_2714	1.22e-161	489.0	COG0574@1|root,COG0784@1|root,COG0574@2|Bacteria,COG0784@2|Bacteria,2NQKM@2323|unclassified Bacteria	2|Bacteria	G	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PPDK_N,Response_reg,SpoIIE
k59_454559_1	861299.J421_4515	1.06e-25	105.0	COG3507@1|root,COG3507@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 43 family	-	-	3.2.1.37,3.2.1.55	ko:K01198,ko:K01209	ko00520,ko01100,map00520,map01100	-	R01433,R01762	RC00467	ko00000,ko00001,ko01000	-	GH43,GH51	-	Glyco_hydro_43
k59_454559_2	1408473.JHXO01000008_gene2886	6.2e-11	63.2	COG2091@1|root,COG2091@2|Bacteria,4NFQ6@976|Bacteroidetes,2FS4M@200643|Bacteroidia	976|Bacteroidetes	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
k59_1065842_1	488538.SAR116_0647	2.75e-12	65.5	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,2TSGS@28211|Alphaproteobacteria,4BPSU@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	Q	Permease MlaE	mlaE	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
k59_1065842_2	1528106.JRJE01000004_gene655	6.26e-89	268.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,2TR2I@28211|Alphaproteobacteria,2JQ66@204441|Rhodospirillales	204441|Rhodospirillales	Q	COG1127 ABC-type transport system involved in resistance to organic solvents, ATPase component	mkl	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
k59_1677341_1	1122925.KB895384_gene3128	7.35e-21	89.4	COG3415@1|root,COG3415@2|Bacteria,1VHRG@1239|Firmicutes,4I856@91061|Bacilli,26YXI@186822|Paenibacillaceae	91061|Bacilli	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32
k59_1677341_2	1122925.KB895384_gene3127	2.9e-22	88.2	COG3335@1|root,COG3335@2|Bacteria	2|Bacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_28,HTH_32
k59_1732891_1	266834.SMc00605	1.78e-17	82.4	COG0625@1|root,COG0625@2|Bacteria,1RGTA@1224|Proteobacteria,2U714@28211|Alphaproteobacteria,4BMJH@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	Glutathione S-transferase, N-terminal domain	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C_2,GST_N_3
k59_65091_1	196164.23491876	3.24e-31	124.0	COG3385@1|root,COG3385@2|Bacteria,2GKQB@201174|Actinobacteria,22QYT@1653|Corynebacteriaceae	201174|Actinobacteria	L	Insertion element 4 transposase N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,Nterm_IS4
k59_1177083_1	861299.J421_2994	1.25e-72	242.0	COG0525@1|root,COG0525@2|Bacteria,1ZSXQ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
k59_676990_1	1379270.AUXF01000005_gene680	0.000148	43.9	2DENK@1|root,2ZNKE@2|Bacteria,1ZV91@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_788102_2	935837.JAEK01000018_gene804	6.55e-10	58.9	COG2077@1|root,COG2077@2|Bacteria,1V474@1239|Firmicutes,4HFMW@91061|Bacilli,1ZARA@1386|Bacillus	91061|Bacilli	O	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides	tpx	-	1.11.1.15	ko:K11065	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA,Redoxin
k59_1399397_1	1123261.AXDW01000005_gene2521	3.51e-07	52.4	COG0429@1|root,COG0429@2|Bacteria,1MWV1@1224|Proteobacteria,1RN39@1236|Gammaproteobacteria,1X3GG@135614|Xanthomonadales	135614|Xanthomonadales	S	hydrolase of the alpha beta-hydrolase fold	-	-	-	ko:K07019	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
k59_287686_1	760192.Halhy_4084	7.4e-69	220.0	COG0604@1|root,COG0604@2|Bacteria,4NHHT@976|Bacteroidetes,1IT0D@117747|Sphingobacteriia	976|Bacteroidetes	C	COGs COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_N_2,ADH_zinc_N_2
k59_1343731_1	189753.AXAS01000041_gene2534	1.02e-48	167.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
k59_1010548_1	1472716.KBK24_0113765	6.59e-35	130.0	COG2890@1|root,COG2890@2|Bacteria,1MXCQ@1224|Proteobacteria,2VP72@28216|Betaproteobacteria,1K3M1@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_31
k59_1732918_2	243232.MJ_1587	4.15e-18	82.4	COG0613@1|root,arCOG00306@2157|Archaea,2Y7J7@28890|Euryarchaeota,23RVE@183939|Methanococci	183939|Methanococci	S	SMART phosphoesterase PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PHP_C
k59_342921_1	253839.SSNG_03525	1.13e-09	63.9	COG0515@1|root,COG0515@2|Bacteria,2GJQK@201174|Actinobacteria	201174|Actinobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
k59_1233802_1	930169.B5T_01662	8.08e-55	185.0	COG1960@1|root,COG1960@2|Bacteria,1MUBH@1224|Proteobacteria,1RPNI@1236|Gammaproteobacteria,1XNDN@135619|Oceanospirillales	135619|Oceanospirillales	I	COG1960 Acyl-CoA dehydrogenases	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_509899_1	337191.KTR9_4419	0.000204	47.4	COG1178@1|root,COG1178@2|Bacteria,2GKDH@201174|Actinobacteria,4GEVA@85026|Gordoniaceae	201174|Actinobacteria	U	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02011,ko:K02063	ko02010,map02010	M00190,M00191	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10,3.A.1.19	-	-	BPD_transp_1,SBP_bac_6
k59_120509_1	1229205.BUPH_01898	4.44e-121	374.0	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,2VK2H@28216|Betaproteobacteria,1K43X@119060|Burkholderiaceae	28216|Betaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N,IF2_assoc
k59_732700_1	1307759.JOMJ01000003_gene1878	1.28e-100	308.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,42M52@68525|delta/epsilon subdivisions,2WIRK@28221|Deltaproteobacteria,2M84Y@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
k59_1455457_1	158500.BV97_02576	4.02e-79	248.0	COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,2TSEY@28211|Alphaproteobacteria,2K0YF@204457|Sphingomonadales	204457|Sphingomonadales	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
k59_1677399_1	1454007.JAUG01000045_gene3790	3.35e-90	279.0	COG3344@1|root,COG3344@2|Bacteria,4NGGU@976|Bacteroidetes,1IVX8@117747|Sphingobacteriia	976|Bacteroidetes	L	Group II intron, maturase-specific domain	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,Intron_maturas2,RVT_1
k59_1510706_1	243231.GSU1888	8.02e-83	252.0	COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,42M4J@68525|delta/epsilon subdivisions,2WJM8@28221|Deltaproteobacteria,43T7P@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	PFAM ABC transporter related	lptB	-	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran,BCA_ABC_TP_C
k59_1621520_1	1123511.KB905846_gene2645	2.34e-27	114.0	COG3705@1|root,COG3705@2|Bacteria,1TPZZ@1239|Firmicutes,4H1WC@909932|Negativicutes	909932|Negativicutes	E	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine	hisZ	-	-	ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002	-	-	-	tRNA-synt_His
k59_342956_1	203122.Sde_0034	5.4e-11	66.6	COG3291@1|root,COG3420@1|root,COG3291@2|Bacteria,COG3420@2|Bacteria,1RBY7@1224|Proteobacteria,1SYWB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Chondroitinase B	-	-	-	-	-	-	-	-	-	-	-	-	Chondroitinas_B,F5_F8_type_C
k59_899618_2	335543.Sfum_3682	7.98e-35	125.0	COG2930@1|root,COG2930@2|Bacteria,1RHV6@1224|Proteobacteria,42TN0@68525|delta/epsilon subdivisions,2WQ75@28221|Deltaproteobacteria,2MQM3@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Las17-binding protein actin regulator	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
k59_120542_1	1121405.dsmv_0108	8.51e-20	89.4	COG1812@1|root,COG1812@2|Bacteria,1QPB9@1224|Proteobacteria,42YHC@68525|delta/epsilon subdivisions,2WTU3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM S-adenosylmethionine synthetase (MAT)	metK-2	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_Synthase
k59_1233841_1	479434.Sthe_1945	2.93e-85	265.0	COG3288@1|root,COG3288@2|Bacteria,2GB86@200795|Chloroflexi,27XYV@189775|Thermomicrobia	189775|Thermomicrobia	C	Alanine dehydrogenase/PNT, N-terminal domain	-	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
k59_1343793_1	504472.Slin_3379	3.49e-40	151.0	COG2866@1|root,COG2866@2|Bacteria,4P1T6@976|Bacteroidetes	976|Bacteroidetes	E	Zinc carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
k59_232251_1	1040989.AWZU01000007_gene690	1.19e-46	161.0	COG1319@1|root,COG1319@2|Bacteria,1MUDB@1224|Proteobacteria,2TTJF@28211|Alphaproteobacteria,3JUB1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	CO dehydrogenase flavoprotein C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	CO_deh_flav_C,FAD_binding_5
k59_788181_2	1379270.AUXF01000001_gene2809	4.34e-55	187.0	COG0006@1|root,COG0006@2|Bacteria,1ZSPF@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Metallopeptidase family M24	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M24
k59_176331_1	234267.Acid_0099	1.08e-47	164.0	2EBMM@1|root,335MT@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1233862_2	1123371.ATXH01000006_gene896	3.01e-17	82.8	COG0568@1|root,COG0568@2|Bacteria,2GH6K@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03089	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_1455509_1	469383.Cwoe_2935	7.23e-93	286.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,4CPPT@84995|Rubrobacteria	84995|Rubrobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE_2
k59_176342_1	395495.Lcho_1330	5.51e-14	75.5	COG1404@1|root,COG5492@1|root,COG1404@2|Bacteria,COG5492@2|Bacteria,1MU3S@1224|Proteobacteria,2VIXC@28216|Betaproteobacteria,1KJFV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Belongs to the peptidase S8 family	mprA	-	-	ko:K14645	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Big_3_2,Big_3_3,Peptidase_S8
k59_954706_1	754477.Q7C_2435	1.12e-40	145.0	COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,1RM8Z@1236|Gammaproteobacteria,460B4@72273|Thiotrichales	72273|Thiotrichales	O	HflC and HflK could regulate a protease	hflC	-	-	ko:K04087	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
k59_1732997_1	566461.SSFG_07829	6.99e-36	135.0	COG2141@1|root,COG2141@2|Bacteria	2|Bacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_9873_1	936573.HMPREF1147_0476	4.23e-66	212.0	COG1239@1|root,COG1239@2|Bacteria,1U356@1239|Firmicutes,4H2X9@909932|Negativicutes	909932|Negativicutes	H	Magnesium chelatase, subunit ChlI	chlI	-	6.6.1.1	ko:K03404,ko:K03405	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	-	AAA_5,Mg_chelatase
k59_1122063_1	330084.JNYZ01000051_gene8962	1.72e-30	123.0	COG0815@1|root,COG0815@2|Bacteria,2GP8X@201174|Actinobacteria,4EA3Z@85010|Pseudonocardiales	201174|Actinobacteria	M	Carbon-nitrogen hydrolase	-	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
k59_843305_1	1047013.AQSP01000122_gene2241	1.76e-69	222.0	COG2230@1|root,COG2230@2|Bacteria,2NQG3@2323|unclassified Bacteria	2|Bacteria	M	C-methyltransferase C-terminal domain	-	-	2.1.1.294,2.1.1.79,2.7.1.181	ko:K00574,ko:K18827	-	-	R10657,R10658	RC00002,RC00003,RC00078,RC03220	ko00000,ko01000,ko01005	-	-	-	MethyTransf_Reg,Methyltransf_14,Methyltransf_23,Methyltransf_25,Methyltransf_31
k59_788216_1	32057.KB217478_gene3915	3.29e-46	166.0	COG1086@1|root,COG1086@2|Bacteria,1G18C@1117|Cyanobacteria,1HJSC@1161|Nostocales	1117|Cyanobacteria	GM	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_3,EAL,Polysacc_synt_2
k59_843306_1	861299.J421_2719	1.34e-66	216.0	COG0213@1|root,COG0213@2|Bacteria,1ZTBE@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Pyrimidine nucleoside phosphorylase C-terminal domain	-	-	2.4.2.2	ko:K00756	ko00240,ko01100,map00240,map01100	-	R01570,R01876,R02296,R02484	RC00063	ko00000,ko00001,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
k59_1733010_1	555779.Dthio_PD0643	6.32e-61	208.0	COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,42MSS@68525|delta/epsilon subdivisions,2WIN2@28221|Deltaproteobacteria,2M99D@213115|Desulfovibrionales	28221|Deltaproteobacteria	EQ	Hydantoinaseoxoprolinase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1638,Hydant_A_N,Hydantoinase_A
k59_232292_1	1120956.JHZK01000010_gene2729	5.41e-69	225.0	COG0607@1|root,COG2897@1|root,COG0607@2|Bacteria,COG2897@2|Bacteria,1MU3V@1224|Proteobacteria,2TSGP@28211|Alphaproteobacteria,1JPPY@119043|Rhodobiaceae	28211|Alphaproteobacteria	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_1068093_1	1122138.AQUZ01000004_gene888	2.64e-164	476.0	COG1053@1|root,COG1053@2|Bacteria,2GJ45@201174|Actinobacteria,4DPTE@85009|Propionibacteriales	201174|Actinobacteria	C	PFAM fumarate reductase succinate dehydrogenase flavoprotein domain protein	frdA	GO:0000104,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006091,GO:0006113,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016627,GO:0022900,GO:0032991,GO:0044237,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045273,GO:0045274,GO:0045283,GO:0045284,GO:0045333,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803	1.3.5.1,1.3.5.4,1.4.3.16	ko:K00239,ko:K00244,ko:K00278	ko00020,ko00190,ko00250,ko00620,ko00650,ko00720,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,ko05134,map00020,map00190,map00250,map00620,map00650,map00720,map00760,map01100,map01110,map01120,map01130,map01200,map02020,map05134	M00009,M00011,M00115,M00149,M00150,M00173,M00374,M00376	R00357,R00481,R02164	RC00006,RC00045,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1552	FAD_binding_2,Succ_DH_flav_C
k59_122633_1	929556.Solca_1350	2.56e-34	130.0	COG0838@1|root,COG0838@2|Bacteria,4NQET@976|Bacteroidetes,1ISH2@117747|Sphingobacteriia	976|Bacteroidetes	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoA	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
k59_790366_1	572547.Amico_0701	4.49e-73	242.0	COG1185@1|root,COG1185@2|Bacteria,3T9RU@508458|Synergistetes	508458|Synergistetes	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
k59_67296_2	189753.AXAS01000004_gene1032	1.01e-44	157.0	COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,2TQSN@28211|Alphaproteobacteria,3JRV2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Aminotransferase class-V	MA20_43180	-	2.6.1.44,2.6.1.45,2.6.1.51	ko:K00830	ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	M00346,M00532	R00369,R00372,R00585,R00588	RC00006,RC00008,RC00018	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
k59_901852_1	936136.ARRT01000006_gene1421	1.44e-22	101.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4B9BA@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,TPR_16,TPR_8
k59_1367034_2	671143.DAMO_2181	1.08e-61	201.0	COG1219@1|root,COG1219@2|Bacteria,2NNN2@2323|unclassified Bacteria	2|Bacteria	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	GO:0000166,GO:0000502,GO:0002020,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009376,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019899,GO:0019904,GO:0030163,GO:0030164,GO:0030312,GO:0030554,GO:0031333,GO:0031597,GO:0032271,GO:0032272,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043254,GO:0043335,GO:0044087,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051301,GO:0051704,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0097718,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
k59_479114_1	5286.M7WY92	7.05e-25	106.0	COG0069@1|root,KOG0399@2759|Eukaryota,38E4E@33154|Opisthokonta,3NUMZ@4751|Fungi,3UZFM@5204|Basidiomycota,2YCHG@29000|Pucciniomycotina	4751|Fungi	E	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	GLT1	GO:0001505,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016040,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0017144,GO:0019676,GO:0019740,GO:0019752,GO:0030447,GO:0036267,GO:0040007,GO:0042133,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043648,GO:0043650,GO:0044182,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045181,GO:0046394,GO:0055114,GO:0065007,GO:0065008,GO:0070783,GO:0071704,GO:0097054,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.13,1.4.1.14	ko:K00264	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,GATase_2,GXGXG,Glu_syn_central,Glu_synthase,Pyr_redox_2
k59_479114_2	211114.JOEF01000005_gene2305	2.36e-60	199.0	COG2025@1|root,COG2025@2|Bacteria,2GJWH@201174|Actinobacteria,4DY2C@85010|Pseudonocardiales	201174|Actinobacteria	C	Electron transfer flavoprotein alpha subunit	etfA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
k59_924144_1	1122927.KB895412_gene1328	3.6e-55	187.0	COG0156@1|root,COG0156@2|Bacteria,1TPUX@1239|Firmicutes,4HAH3@91061|Bacilli,26SUT@186822|Paenibacillaceae	91061|Bacilli	E	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	bioF	GO:0003674,GO:0003824,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008710,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.3.1.29,2.3.1.47	ko:K00639,ko:K00652	ko00260,ko00780,ko01100,map00260,map00780,map01100	M00123,M00573,M00577	R00371,R03210,R10124	RC00004,RC00039,RC00394,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_1145286_1	1122915.AUGY01000081_gene3239	6.61e-62	206.0	COG0477@1|root,COG2814@2|Bacteria,1VSW8@1239|Firmicutes,4HUQC@91061|Bacilli,2773A@186822|Paenibacillaceae	91061|Bacilli	EGP	Belongs to the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
k59_1422166_1	765420.OSCT_1463	9.22e-73	231.0	COG0626@1|root,COG0626@2|Bacteria,2G7Q6@200795|Chloroflexi,3770M@32061|Chloroflexia	32061|Chloroflexia	H	PFAM Cys Met metabolism pyridoxal-phosphate-dependent	-	-	4.4.1.11	ko:K01761	ko00270,ko00450,map00270,map00450	-	R00654,R04770	RC00196,RC00348,RC01209,RC01210	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
k59_479127_2	1547437.LL06_25230	3.62e-74	226.0	COG0066@1|root,COG0066@2|Bacteria,1RBRQ@1224|Proteobacteria,2UA0M@28211|Alphaproteobacteria,43M74@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Aconitase C-terminal domain	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
k59_1367051_1	748727.CLJU_c18900	5.21e-78	254.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247T8@186801|Clostridia,36EMB@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_532689_1	158787.BSCA_2473	3.31e-16	80.9	COG1355@1|root,COG2078@1|root,COG1355@2|Bacteria,COG2078@2|Bacteria,2ISCW@201174|Actinobacteria,4D0HC@85004|Bifidobacteriales	201174|Actinobacteria	S	AMMECR1	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	AMMECR1,Memo
k59_754983_1	573370.DMR_41050	1.26e-57	189.0	COG0348@1|root,COG0348@2|Bacteria,1PQG0@1224|Proteobacteria,42PV1@68525|delta/epsilon subdivisions,2WK8H@28221|Deltaproteobacteria,2MF54@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5
k59_1089158_1	1280946.HY29_13125	3.83e-39	144.0	COG3108@1|root,COG3108@2|Bacteria,1RAMQ@1224|Proteobacteria,2UQDA@28211|Alphaproteobacteria,43WJZ@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	Peptidase M15	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M15_3
k59_311167_2	1292035.H476_1094	2.75e-28	113.0	COG0726@1|root,COG0726@2|Bacteria,1V6DN@1239|Firmicutes,24JSE@186801|Clostridia,25UFX@186804|Peptostreptococcaceae	186801|Clostridia	G	Polysaccharide deacetylase	-	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	Polysacc_deac_1
k59_865029_2	439235.Dalk_3629	0.000351	44.7	COG0712@1|root,COG0712@2|Bacteria,1MVRH@1224|Proteobacteria,42U68@68525|delta/epsilon subdivisions,2WQJS@28221|Deltaproteobacteria,2MJKI@213118|Desulfobacterales	28221|Deltaproteobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
k59_87810_1	1122179.KB890439_gene1635	5.99e-58	194.0	COG0673@1|root,COG0673@2|Bacteria,4NF96@976|Bacteroidetes,1IQ5B@117747|Sphingobacteriia	976|Bacteroidetes	S	Oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
k59_1589269_1	1000565.METUNv1_02416	6.19e-07	51.6	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VNYV@28216|Betaproteobacteria,2KV5E@206389|Rhodocyclales	206389|Rhodocyclales	T	Bacterial regulatory protein, Fis family	-	-	-	ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1589269_2	944480.ATUV01000001_gene1328	4.69e-27	111.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42NSM@68525|delta/epsilon subdivisions,2WJXQ@28221|Deltaproteobacteria,2M7K6@213113|Desulfurellales	28221|Deltaproteobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_532718_1	477184.KYC_14912	3.36e-41	137.0	COG2963@1|root,COG2963@2|Bacteria,1MZ3D@1224|Proteobacteria,2VTZ8@28216|Betaproteobacteria,3T7UX@506|Alcaligenaceae	28216|Betaproteobacteria	L	Transposase	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_532718_2	375451.RD1_3449	3.44e-15	75.1	COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,2P3AF@2433|Roseobacter	28211|Alphaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
k59_1089186_1	1380391.JIAS01000017_gene543	6.07e-89	276.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
k59_142813_1	1423321.AS29_13010	3.34e-12	72.0	COG0475@1|root,COG0569@1|root,COG0475@2|Bacteria,COG0569@2|Bacteria,1TS32@1239|Firmicutes,4H9Q5@91061|Bacilli,1ZBJR@1386|Bacillus	91061|Bacilli	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	yjbQ	-	-	ko:K03455,ko:K03499	-	-	-	-	ko00000,ko02000	2.A.37,2.A.38.1,2.A.38.4	-	-	Na_H_Exchanger,TrkA_C,TrkA_N
k59_1367082_1	158787.BSCA_1835	1.45e-09	59.7	COG1716@1|root,COG1716@2|Bacteria,2GK99@201174|Actinobacteria,4D0R3@85004|Bifidobacteriales	201174|Actinobacteria	T	Inner membrane component of T3SS, cytoplasmic domain	garA	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0006109,GO:0006110,GO:0006140,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009894,GO:0009895,GO:0009987,GO:0010563,GO:0010675,GO:0010677,GO:0016020,GO:0016310,GO:0019219,GO:0019220,GO:0019222,GO:0019538,GO:0030312,GO:0030808,GO:0030809,GO:0030811,GO:0030812,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031329,GO:0031330,GO:0036211,GO:0042325,GO:0042326,GO:0042802,GO:0043170,GO:0043412,GO:0043457,GO:0043467,GO:0043470,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045820,GO:0045912,GO:0045934,GO:0045936,GO:0045980,GO:0046777,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051174,GO:0051193,GO:0051195,GO:0051196,GO:0051198,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:1900371,GO:1900372,GO:1900542,GO:1900543,GO:1901564,GO:1903578,GO:1903579,GO:2001169,GO:2001170	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl,zinc_ribbon_2
k59_1367082_2	1329250.WOSG25_041010	0.000418	44.7	COG0631@1|root,COG0631@2|Bacteria,1V6K5@1239|Firmicutes,4HCDR@91061|Bacilli,4AX5B@81850|Leuconostocaceae	91061|Bacilli	T	Serine threonine protein phosphatase	stp	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
k59_365542_1	452637.Oter_2365	3.56e-31	116.0	COG0605@1|root,COG0605@2|Bacteria,46SQF@74201|Verrucomicrobia,3K7XS@414999|Opitutae	414999|Opitutae	P	Iron/manganese superoxide dismutases, alpha-hairpin domain	-	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
k59_365542_2	1382359.JIAL01000001_gene505	9.5e-57	189.0	COG2008@1|root,COG2008@2|Bacteria,3Y472@57723|Acidobacteria,2JIUS@204432|Acidobacteriia	204432|Acidobacteriia	E	PFAM aromatic amino acid beta-eliminating lyase threonine aldolase	-	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
k59_1312191_1	382464.ABSI01000012_gene2193	5.16e-13	72.0	COG5616@1|root,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,TPR_16
k59_1754611_1	436229.JOEH01000014_gene6129	7.8e-07	56.2	COG2319@1|root,COG2319@2|Bacteria,2GJN3@201174|Actinobacteria,2NEAZ@228398|Streptacidiphilus	201174|Actinobacteria	T	WD domain, G-beta repeat	-	-	-	-	-	-	-	-	-	-	-	-	WD40
k59_1478488_1	644282.Deba_2059	8.61e-33	125.0	COG0559@1|root,COG0559@2|Bacteria,1N5XH@1224|Proteobacteria,42PN7@68525|delta/epsilon subdivisions,2WIRP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_142833_2	926569.ANT_06070	5.35e-33	125.0	COG1181@1|root,COG1181@2|Bacteria,2G5RS@200795|Chloroflexi	200795|Chloroflexi	F	Belongs to the D-alanine--D-alanine ligase family	-	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
k59_1145360_1	985762.SAGN_00945	4.77e-71	224.0	COG0468@1|root,COG0468@2|Bacteria,1TPD5@1239|Firmicutes,4HAG5@91061|Bacilli,4GXFM@90964|Staphylococcaceae	91061|Bacilli	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009292,GO:0009294,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0030420,GO:0031668,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0044764,GO:0050896,GO:0051704,GO:0051716,GO:0071496	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
k59_1754627_2	517417.Cpar_0677	6.54e-55	185.0	COG0686@1|root,COG0686@2|Bacteria,1FEIP@1090|Chlorobi	1090|Chlorobi	C	Belongs to the AlaDH PNT family	-	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
k59_1089244_1	377629.TERTU_0105	4.25e-75	241.0	COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,1RN0R@1236|Gammaproteobacteria,2PN3I@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	S	Sodium:solute symporter family	actP	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	-	SSF
k59_1089244_2	1056512.D515_03870	1.15e-07	51.6	2DDDN@1|root,32U19@2|Bacteria,1N1UD@1224|Proteobacteria,1SAT8@1236|Gammaproteobacteria,1XUWT@135623|Vibrionales	135623|Vibrionales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1701641_1	189425.PGRAT_19655	1.27e-82	270.0	COG2909@1|root,COG2909@2|Bacteria,1UIMV@1239|Firmicutes,4HD7H@91061|Bacilli,26QDM@186822|Paenibacillaceae	91061|Bacilli	K	helix_turn_helix, Lux Regulon	-	-	-	ko:K03556	-	-	-	-	ko00000,ko03000	-	-	-	GerE
k59_642786_1	1175306.GWL_14050	1.9e-59	202.0	COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,2VHFD@28216|Betaproteobacteria,472DF@75682|Oxalobacteraceae	28216|Betaproteobacteria	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
k59_198441_1	861299.J421_0532	4.54e-126	364.0	COG1878@1|root,COG1878@2|Bacteria,1ZV5N@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
k59_924278_1	384765.SIAM614_22377	2.34e-101	301.0	COG3181@1|root,COG3181@2|Bacteria,1MXEX@1224|Proteobacteria,2TTSX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein conserved in bacteria	-	-	-	ko:K07795	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctC
k59_865138_1	1304865.JAGF01000001_gene723	8.49e-13	73.9	COG0642@1|root,COG2205@2|Bacteria,2I2QY@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4173,HAMP,HATPase_c,HisKA
k59_32272_1	990285.RGCCGE502_20275	1.28e-14	75.1	COG4221@1|root,COG4221@2|Bacteria,1MUF8@1224|Proteobacteria,2TUSA@28211|Alphaproteobacteria,4B809@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_532836_1	1267535.KB906767_gene2990	5.99e-22	101.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_1367196_1	443144.GM21_0071	3.63e-158	480.0	COG2132@1|root,COG4733@1|root,COG2132@2|Bacteria,COG4733@2|Bacteria,1R9AF@1224|Proteobacteria	1224|Proteobacteria	Q	Multicopper oxidase, type 2	ompB	-	-	-	-	-	-	-	-	-	-	-	ASH,Cu-oxidase_2,fn3
k59_1422323_1	644107.SL1157_0819	9.23e-102	321.0	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,2TQMY@28211|Alphaproteobacteria,4NBBN@97050|Ruegeria	28211|Alphaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc
k59_1367203_1	1235457.C404_09860	3.65e-11	69.7	COG0477@1|root,COG2814@2|Bacteria,1QTX0@1224|Proteobacteria,2W3XP@28216|Betaproteobacteria,1KG3Q@119060|Burkholderiaceae	28216|Betaproteobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
k59_1145456_1	1347369.CCAD010000065_gene3803	4.56e-17	83.2	COG2345@1|root,COG2345@2|Bacteria,1V5Q5@1239|Firmicutes,4HHMX@91061|Bacilli,1ZEGI@1386|Bacillus	91061|Bacilli	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,HTH_20,HTH_24,HTH_5,HTH_DeoR
k59_1035312_1	861299.J421_3849	3.57e-58	197.0	COG0265@1|root,COG0265@2|Bacteria,1ZTG6@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Trypsin	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
k59_1533302_1	483219.LILAB_10280	1.03e-52	181.0	COG0006@1|root,COG0006@2|Bacteria,1MVHD@1224|Proteobacteria	1224|Proteobacteria	E	Xaa-Pro aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M24
k59_1643152_1	1121033.AUCF01000005_gene5366	1.09e-63	207.0	COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,2TRDA@28211|Alphaproteobacteria,2JP8I@204441|Rhodospirillales	204441|Rhodospirillales	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	2.7.1.71,4.2.3.4	ko:K01735,ko:K13829	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R03083	RC00002,RC00078,RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase,SKI
k59_1754728_1	196367.JNFG01000041_gene7825	4.89e-19	91.7	COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,2VI8X@28216|Betaproteobacteria,1K1W4@119060|Burkholderiaceae	28216|Betaproteobacteria	L	DEAD DEAH box helicase domain protein	lhr	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
k59_421728_1	420324.KI911940_gene5145	1.85e-21	91.7	COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,2UFRX@28211|Alphaproteobacteria,1JURB@119045|Methylobacteriaceae	28211|Alphaproteobacteria	O	Hsp20/alpha crystallin family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
k59_421728_2	1284352.AOIG01000010_gene1960	2.73e-13	70.5	COG1131@1|root,COG1131@2|Bacteria,1TP4J@1239|Firmicutes,4HBGH@91061|Bacilli,26QWM@186822|Paenibacillaceae	91061|Bacilli	V	ABC transporter, ATP-binding protein	bcrA3	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1312344_1	1122918.KB907249_gene3898	4.08e-80	253.0	COG0281@1|root,COG0281@2|Bacteria,1TPJ3@1239|Firmicutes,4H9WR@91061|Bacilli,26QD2@186822|Paenibacillaceae	91061|Bacilli	C	Malic enzyme	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	Malic_M,malic
k59_1589462_1	1537994.JQFW01000056_gene798	1.18e-52	185.0	COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,1RQGQ@1236|Gammaproteobacteria,46CR9@72275|Alteromonadaceae	1236|Gammaproteobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_978970_1	1120705.FG95_02704	3.02e-20	94.7	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2TSSI@28211|Alphaproteobacteria,2K12J@204457|Sphingomonadales	204457|Sphingomonadales	I	synthetase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
k59_1312354_1	404589.Anae109_1110	4.16e-05	50.8	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,42MCN@68525|delta/epsilon subdivisions,2WIYA@28221|Deltaproteobacteria,2YV0J@29|Myxococcales	28221|Deltaproteobacteria	T	Signal transduction histidine kinase	ntrY	-	2.7.13.3	ko:K13598	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4
k59_1422379_1	926550.CLDAP_32670	8.04e-25	107.0	COG1574@1|root,COG1574@2|Bacteria,2G5YJ@200795|Chloroflexi	200795|Chloroflexi	S	PFAM Amidohydrolase 3	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_700728_1	1424334.W822_06930	6.02e-09	57.8	COG2267@1|root,COG2267@2|Bacteria,1MWHN@1224|Proteobacteria,2VI1B@28216|Betaproteobacteria	28216|Betaproteobacteria	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
k59_700728_2	196490.AUEZ01000021_gene783	1.4e-20	91.7	COG0596@1|root,COG0596@2|Bacteria,1QWWW@1224|Proteobacteria,2U88T@28211|Alphaproteobacteria,3K0PK@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
k59_254352_1	85643.Tmz1t_0492	1.55e-37	143.0	COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,1MU9M@1224|Proteobacteria,2VJUR@28216|Betaproteobacteria,2KX0V@206389|Rhodocyclales	206389|Rhodocyclales	S	AAA domain	-	-	-	ko:K07028	-	-	-	-	ko00000	-	-	-	AAA_33,APH
k59_532913_1	642492.Clole_3499	1.86e-109	325.0	COG3842@1|root,COG3842@2|Bacteria,1TP2M@1239|Firmicutes,247JR@186801|Clostridia	186801|Clostridia	P	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	ugpC_1	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE,TOBE_2
k59_532917_1	861299.J421_3475	1.21e-27	114.0	COG1463@1|root,COG1463@2|Bacteria	2|Bacteria	Q	ABC-type transport system involved in resistance to organic solvents, periplasmic component	ttg2C	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
k59_1754756_1	631454.N177_3415	1.03e-43	149.0	COG2872@1|root,COG2872@2|Bacteria,1MY0P@1224|Proteobacteria,2TRRW@28211|Alphaproteobacteria,1JNUN@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Threonyl and Alanyl tRNA synthetase second additional domain	alaS2	GO:0000049,GO:0002161,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0097159,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K07050	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA-synt_2c,tRNA_SAD
k59_1754756_2	402881.Plav_2990	1.72e-47	160.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2TR4W@28211|Alphaproteobacteria,1JNEK@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	Pyridoxal-phosphate dependent enzyme	cysB	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_644711_1	1216007.AOPM01000002_gene2518	4.19e-09	63.2	COG1913@1|root,COG1913@2|Bacteria,1MY52@1224|Proteobacteria,1RSIP@1236|Gammaproteobacteria,2Q0NK@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	S	Domain of unknown function (DUF5117)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4953,DUF5117
k59_1202036_1	448385.sce2560	7.79e-39	145.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2YU4Y@29|Myxococcales	28221|Deltaproteobacteria	T	Two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_757246_1	1121403.AUCV01000045_gene1130	7.82e-22	99.8	COG0642@1|root,COG2204@1|root,COG2204@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,43CHE@68525|delta/epsilon subdivisions,2X7SI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
k59_981099_1	316274.Haur_2134	7.14e-89	268.0	COG2041@1|root,COG2041@2|Bacteria,2G618@200795|Chloroflexi,375BB@32061|Chloroflexia	32061|Chloroflexia	C	Part of the MsrPQ system that repairs oxidized cell envelope proteins containing methionine sulfoxide residues (Met- O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated cell envelope proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide	msrP	-	-	ko:K07147	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_molyb
k59_200232_1	1379270.AUXF01000002_gene1199	2.08e-31	115.0	COG4968@1|root,COG4968@2|Bacteria,1ZTWU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	NU	Prokaryotic N-terminal methylation motif	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
k59_90009_1	1444711.CCJF01000003_gene91	2.11e-59	199.0	COG0058@1|root,COG0058@2|Bacteria,2JFEH@204428|Chlamydiae	204428|Chlamydiae	G	Carbohydrate phosphorylase	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
k59_1091411_1	1238182.C882_2022	1.03e-38	142.0	COG1565@1|root,COG1565@2|Bacteria,1N3CJ@1224|Proteobacteria,2TRHW@28211|Alphaproteobacteria,2JPV6@204441|Rhodospirillales	204441|Rhodospirillales	S	Putative S-adenosyl-L-methionine-dependent methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_28
k59_1091411_2	765698.Mesci_2166	2.45e-07	52.0	COG1496@1|root,COG1496@2|Bacteria,1MW2H@1224|Proteobacteria,2TTXU@28211|Alphaproteobacteria,43HNE@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Belongs to the multicopper oxidase YfiH RL5 family	yfiH	-	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
k59_313467_2	309803.CTN_1761	2.42e-07	54.3	COG1846@1|root,COG1846@2|Bacteria,2GD7T@200918|Thermotogae	200918|Thermotogae	K	Transcriptional regulator, MarR family	-	-	-	-	-	-	-	-	-	-	-	-	MarR
k59_981120_1	671143.DAMO_1566	7.63e-38	143.0	COG0037@1|root,COG0037@2|Bacteria,2NPAZ@2323|unclassified Bacteria	2|Bacteria	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	2.4.2.8,6.3.4.19	ko:K00760,ko:K04075	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245,R09597	RC00063,RC00122,RC02633,RC02634	ko00000,ko00001,ko01000,ko03016	-	-	-	ATP_bind_3,Pribosyltran,TilS,TilS_C
k59_1591691_1	187272.Mlg_2061	6.07e-33	129.0	COG0477@1|root,COG2814@2|Bacteria,1N2NP@1224|Proteobacteria,1RP1Y@1236|Gammaproteobacteria,1WWDI@135613|Chromatiales	135613|Chromatiales	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1259560_1	1129794.C427_0623	7.79e-15	71.2	2EEXG@1|root,338QU@2|Bacteria,1NBQ6@1224|Proteobacteria,1SG5N@1236|Gammaproteobacteria,46B7B@72275|Alteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_312376_1	1192034.CAP_6251	9e-58	192.0	COG2159@1|root,COG2159@2|Bacteria,1N0C7@1224|Proteobacteria,437UX@68525|delta/epsilon subdivisions,2X34D@28221|Deltaproteobacteria,2YU7H@29|Myxococcales	1224|Proteobacteria	S	Amidohydrolase	MA20_19310	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
k59_33253_1	1121403.AUCV01000020_gene3098	1.42e-77	242.0	COG0451@1|root,COG0451@2|Bacteria,1MX2J@1224|Proteobacteria,42TZR@68525|delta/epsilon subdivisions,2WQ4T@28221|Deltaproteobacteria,2MNMQ@213118|Desulfobacterales	28221|Deltaproteobacteria	M	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
k59_1036360_1	1267533.KB906735_gene4876	7.31e-26	112.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_33261_1	1408473.JHXO01000010_gene3781	5.67e-39	148.0	COG3250@1|root,COG3250@2|Bacteria,4NE7H@976|Bacteroidetes,2FNT8@200643|Bacteroidia	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 2 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
k59_1090354_1	388413.ALPR1_09123	4.97e-60	205.0	COG2866@1|root,COG2866@2|Bacteria,4NIJ0@976|Bacteroidetes,47K8F@768503|Cytophagia	976|Bacteroidetes	E	Zn_pept	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
k59_756240_1	493475.GARC_4530	5.95e-82	259.0	COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,1RRYB@1236|Gammaproteobacteria,46DNY@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
k59_1479666_1	370438.PTH_2540	1.73e-17	82.4	COG0151@1|root,COG0151@2|Bacteria,1UHN9@1239|Firmicutes,25E76@186801|Clostridia,2609N@186807|Peptococcaceae	186801|Clostridia	F	Belongs to the GARS family	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
k59_1479666_2	121225.PHUM474680-PA	0.000527	43.1	COG3590@1|root,KOG3624@2759|Eukaryota,38BNF@33154|Opisthokonta,3B9I2@33208|Metazoa,3CW8Q@33213|Bilateria,41XSV@6656|Arthropoda,3SIXK@50557|Insecta,3ECH5@33342|Paraneoptera	33208|Metazoa	E	Peptidase family M13	MMEL1	GO:0001501,GO:0001503,GO:0001655,GO:0001775,GO:0001822,GO:0001990,GO:0001991,GO:0002002,GO:0002003,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0003008,GO:0003013,GO:0003044,GO:0003073,GO:0003081,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005575,GO:0005576,GO:0005615,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005794,GO:0005886,GO:0005887,GO:0005903,GO:0006464,GO:0006508,GO:0006518,GO:0006793,GO:0006807,GO:0006810,GO:0006887,GO:0006955,GO:0007154,GO:0007267,GO:0007275,GO:0007568,GO:0007569,GO:0007600,GO:0008015,GO:0008021,GO:0008150,GO:0008152,GO:0008217,GO:0008233,GO:0008237,GO:0008238,GO:0008270,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009888,GO:0009987,GO:0010033,GO:0010224,GO:0010467,GO:0010817,GO:0012505,GO:0012506,GO:0016020,GO:0016021,GO:0016192,GO:0016485,GO:0016486,GO:0016528,GO:0016529,GO:0016787,GO:0019233,GO:0019538,GO:0019637,GO:0023052,GO:0030133,GO:0030141,GO:0030282,GO:0030424,GO:0030425,GO:0030659,GO:0030667,GO:0031090,GO:0031214,GO:0031224,GO:0031226,GO:0031410,GO:0031982,GO:0032501,GO:0032502,GO:0032940,GO:0033218,GO:0034097,GO:0034641,GO:0034644,GO:0036211,GO:0036230,GO:0036477,GO:0042119,GO:0042221,GO:0042277,GO:0042445,GO:0042995,GO:0043005,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043299,GO:0043312,GO:0043412,GO:0043603,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0044306,GO:0044421,GO:0044422,GO:0044424,GO:0044425,GO:0044433,GO:0044444,GO:0044446,GO:0044456,GO:0044459,GO:0044463,GO:0044464,GO:0045055,GO:0045202,GO:0045321,GO:0046449,GO:0046483,GO:0046872,GO:0046903,GO:0046914,GO:0048471,GO:0048513,GO:0048731,GO:0048856,GO:0048869,GO:0050435,GO:0050877,GO:0050886,GO:0050896,GO:0051179,GO:0051234,GO:0051604,GO:0051716,GO:0065007,GO:0065008,GO:0070011,GO:0070141,GO:0070382,GO:0070887,GO:0071214,GO:0071310,GO:0071345,GO:0071478,GO:0071482,GO:0071492,GO:0071493,GO:0071704,GO:0071944,GO:0072001,GO:0072338,GO:0090399,GO:0097242,GO:0097447,GO:0097458,GO:0097708,GO:0098588,GO:0098793,GO:0098805,GO:0098862,GO:0099503,GO:0104004,GO:0120025,GO:0120038,GO:0140096,GO:1901360,GO:1901564	3.4.24.11	ko:K01389,ko:K08635,ko:K08636	ko04614,ko04640,ko04974,ko05010,map04614,map04640,map04974,map05010	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	Peptidase_M13,Peptidase_M13_N
k59_1423395_1	323097.Nham_2691	1.09e-111	349.0	COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,2TR6F@28211|Alphaproteobacteria,3JR8U@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppc	GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase
k59_980016_1	1463917.JODC01000030_gene9526	1.15e-25	112.0	COG2319@1|root,COG2319@2|Bacteria,2GJN3@201174|Actinobacteria	201174|Actinobacteria	F	WD-40 repeat	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31,WD40
k59_643784_2	697282.Mettu_2130	1.53e-57	186.0	COG3217@1|root,COG3217@2|Bacteria,1QTF1@1224|Proteobacteria,1SVMA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	MOSC domain	-	-	-	-	-	-	-	-	-	-	-	-	MOSC
k59_925425_1	485913.Krac_10225	9.69e-42	147.0	COG5662@1|root,COG5662@2|Bacteria	2|Bacteria	K	AntiSigma factor	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
k59_701751_1	991905.SL003B_1479	3.83e-62	198.0	COG0351@1|root,COG0351@2|Bacteria,1MU9J@1224|Proteobacteria,2TUKR@28211|Alphaproteobacteria,4BQ0Z@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	H	Phosphomethylpyrimidine kinase	thiD	-	2.7.1.49,2.7.4.7	ko:K00941	ko00730,ko01100,map00730,map01100	M00127	R03471,R04509	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Phos_pyr_kin
k59_643800_1	472759.Nhal_0690	1.11e-46	166.0	COG0719@1|root,COG0719@2|Bacteria,1MVK0@1224|Proteobacteria,1RP2A@1236|Gammaproteobacteria,1WWK5@135613|Chromatiales	135613|Chromatiales	O	FeS assembly protein SufD	-	-	-	ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
k59_1036414_1	867903.ThesuDRAFT_01451	4e-49	171.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1TP4F@1239|Firmicutes,248MM@186801|Clostridia,3WCD3@538999|Clostridiales incertae sedis	186801|Clostridia	H	Riboflavin biosynthesis protein RibD	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
k59_756277_1	932678.THERU_07040	1.86e-47	169.0	COG3604@1|root,COG3604@2|Bacteria	2|Bacteria	KT	transcription factor binding	norR	GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0001130,GO:0001150,GO:0001151,GO:0001158,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016043,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0022607,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035326,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043254,GO:0043565,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0046872,GO:0046914,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0060255,GO:0065003,GO:0065007,GO:0070026,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2000142,GO:2000144,GO:2001141	-	ko:K02584,ko:K11914,ko:K12146,ko:K12266,ko:K15836	ko02020,ko05132,map02020,map05132	-	-	-	ko00000,ko00001,ko02044,ko03000	-	-	-	GAF,GAF_2,HTH_8,Sigma54_activat
k59_866271_1	861299.J421_3192	1.43e-27	116.0	COG0342@1|root,COG0342@2|Bacteria,1ZTBW@142182|Gemmatimonadetes	142182|Gemmatimonadetes	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
k59_1423424_1	234267.Acid_6898	5.96e-112	334.0	COG3464@1|root,COG3464@2|Bacteria,3Y89T@57723|Acidobacteria	57723|Acidobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3
k59_312447_1	497964.CfE428DRAFT_3867	5.93e-40	134.0	COG1977@1|root,COG1977@2|Bacteria	2|Bacteria	H	Mo-molybdopterin cofactor metabolic process	-	-	2.7.7.80,2.8.1.11	ko:K03636,ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiS
k59_312447_2	58123.JOFJ01000012_gene5398	1.89e-23	97.1	COG4447@1|root,COG4447@2|Bacteria,2GM8J@201174|Actinobacteria,4EH3D@85012|Streptosporangiales	201174|Actinobacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR
k59_1036423_1	1305737.JAFX01000001_gene2038	3.34e-06	52.4	COG0848@1|root,COG0848@2|Bacteria,4NHYQ@976|Bacteroidetes,47JBU@768503|Cytophagia	976|Bacteroidetes	U	Biopolymer transport protein ExbD/TolR	-	-	-	-	-	-	-	-	-	-	-	-	ExbD
k59_866279_1	414684.RC1_0698	7.62e-88	264.0	COG0081@1|root,COG0081@2|Bacteria,1MUE6@1224|Proteobacteria,2TRXP@28211|Alphaproteobacteria,2JQ7H@204441|Rhodospirillales	204441|Rhodospirillales	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
k59_588985_1	861299.J421_0282	2.31e-27	114.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_1313482_1	501479.ACNW01000122_gene2982	7.93e-09	58.5	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctA
k59_1368325_1	1125863.JAFN01000001_gene2919	1.5e-51	172.0	COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,42NR9@68525|delta/epsilon subdivisions,2WKX1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	it plays a direct role in the translocation of protons across the membrane	atpB	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016021,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042777,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
k59_1313504_1	6500.XP_005094129.1	2.37e-44	156.0	COG1804@1|root,KOG3957@2759|Eukaryota,38CWZ@33154|Opisthokonta,3BB7M@33208|Metazoa,3D0JC@33213|Bilateria	33208|Metazoa	I	succinate-hydroxymethylglutarate CoA-transferase activity	SUGCT	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0008410,GO:0016740,GO:0016782,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0047369	2.8.3.13	ko:K18703	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
k59_1479733_2	383407.XOC_0076	4.3e-27	110.0	COG1304@1|root,COG1304@2|Bacteria,1N6KI@1224|Proteobacteria,1RP1W@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)	fni	-	5.3.3.2	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123	RC00455	ko00000,ko00001,ko00002,ko01000	-	-	-	FMN_dh
k59_925483_1	580327.Tthe_0656	1.82e-79	251.0	COG3534@1|root,COG3534@2|Bacteria,1TR7B@1239|Firmicutes,248ZA@186801|Clostridia,42HXK@68295|Thermoanaerobacterales	186801|Clostridia	G	SMART Alpha-L-arabinofuranosidase	-	-	3.2.1.55	ko:K01209	ko00520,map00520	-	R01762	-	ko00000,ko00001,ko01000	-	GH51	-	Alpha-L-AF_C
k59_534050_1	926569.ANT_18970	2.83e-99	293.0	COG0081@1|root,COG0081@2|Bacteria,2G6AW@200795|Chloroflexi	200795|Chloroflexi	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
k59_812205_1	1230476.C207_06130	3.29e-23	90.9	2EIDG@1|root,33C4V@2|Bacteria,1N0P4@1224|Proteobacteria,2UC9K@28211|Alphaproteobacteria,3K073@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_812205_2	1449353.JQMQ01000005_gene4133	1.11e-11	67.0	COG1028@1|root,COG1028@2|Bacteria,2GMEH@201174|Actinobacteria	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
k59_366824_1	1089552.KI911559_gene1759	3.55e-56	197.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,2JPID@204441|Rhodospirillales	204441|Rhodospirillales	T	signal transduction histidine kinase	-	-	2.7.13.3	ko:K13587	ko02020,ko04112,map02020,map04112	M00512	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS_4,PAS_8,PAS_9,Response_reg
k59_1313521_1	365528.KB891252_gene5554	1.13e-32	120.0	COG0802@1|root,COG0802@2|Bacteria,2IKV2@201174|Actinobacteria,4ESZ5@85013|Frankiales	201174|Actinobacteria	S	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	tsaE	GO:0008150,GO:0040007	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
k59_1036460_1	671143.DAMO_3166	1.35e-30	123.0	COG0845@1|root,COG0845@2|Bacteria,2NPBH@2323|unclassified Bacteria	2|Bacteria	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	macA_1	-	-	ko:K02005,ko:K13888	-	M00709	-	-	ko00000,ko00002,ko02000	8.A.1	-	-	HlyD_D23
k59_257423_1	1380391.JIAS01000002_gene3128	9.3e-58	203.0	COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,2TSAJ@28211|Alphaproteobacteria,2JRE2@204441|Rhodospirillales	204441|Rhodospirillales	G	Glycosyl hydrolase 36 superfamily, catalytic domain	-	-	-	ko:K13688	-	-	-	-	ko00000,ko01000,ko01003	-	GH94,GT84	-	Glyco_hydro_36,Glyco_transf_36,Glycoamylase
k59_704032_1	518766.Rmar_0372	2.13e-81	255.0	COG1109@1|root,COG1109@2|Bacteria,4NFU7@976|Bacteroidetes,1FIXK@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III	-	-	-	-	-	-	-	-	-	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_1757795_1	751945.Theos_1247	1.37e-57	190.0	COG0180@1|root,COG0180@2|Bacteria,1WI8T@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	J	PFAM tRNA synthetases class I (W and Y)	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
k59_1039118_1	1392838.AWNM01000019_gene4006	1.45e-28	119.0	COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,2VITF@28216|Betaproteobacteria	28216|Betaproteobacteria	EQ	Hydantoinase B oxoprolinase	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
k59_814229_1	288000.BBta_5489	3.41e-62	199.0	28NKC@1|root,2ZBM7@2|Bacteria,1MWMY@1224|Proteobacteria,2TU05@28211|Alphaproteobacteria,3JS0Z@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	MA20_08580	-	-	-	-	-	-	-	-	-	-	-	Endostatin
k59_146198_1	742766.HMPREF9455_02537	5.46e-27	114.0	COG2866@1|root,COG2866@2|Bacteria,4NEJA@976|Bacteroidetes,2FR0S@200643|Bacteroidia,22Z0C@171551|Porphyromonadaceae	976|Bacteroidetes	E	Zinc carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
k59_1092762_1	1089548.KI783301_gene854	1.52e-11	71.2	COG0287@1|root,COG0287@2|Bacteria,1TPXG@1239|Firmicutes,4HBI4@91061|Bacilli	91061|Bacilli	E	prephenate dehydrogenase	tyrA	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006520,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008977,GO:0009058,GO:0009072,GO:0009073,GO:0009095,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019438,GO:0019752,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.3.1.12	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU22610	ACT,PDH
k59_425003_1	1408433.JHXV01000011_gene2081	4.19e-40	141.0	arCOG07533@1|root,31XFQ@2|Bacteria,4P9XQ@976|Bacteroidetes,1ICVA@117743|Flavobacteriia,2PBXP@246874|Cryomorphaceae	976|Bacteroidetes	S	Domain of unknown function (DUF4386)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4386
k59_257440_2	706587.Desti_1336	2.53e-46	154.0	COG2771@1|root,COG2771@2|Bacteria,1NAK1@1224|Proteobacteria,42VEJ@68525|delta/epsilon subdivisions,2WS0Q@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Protein of unknown function (DUF4019)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4019
k59_1705729_1	94624.Bpet2916	1.21e-57	197.0	COG0534@1|root,COG0534@2|Bacteria,1MUAM@1224|Proteobacteria,2W0EV@28216|Betaproteobacteria	28216|Betaproteobacteria	V	Mate efflux family protein	norM	-	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
k59_35415_1	765952.PUV_08450	2.35e-32	127.0	COG2170@1|root,COG2170@2|Bacteria,2JGVK@204428|Chlamydiae	204428|Chlamydiae	H	Glutamate-cysteine ligase family 2(GCS2)	-	-	-	-	-	-	-	-	-	-	-	-	GCS2
k59_1536503_1	926569.ANT_11800	1.41e-84	283.0	COG2203@1|root,COG3850@1|root,COG2203@2|Bacteria,COG3850@2|Bacteria	2|Bacteria	T	phosphorelay sensor kinase activity	-	-	2.7.13.3	ko:K07638,ko:K07673,ko:K21009	ko02020,ko02025,ko02026,map02020,map02025,map02026	M00445,M00471,M00742,M00743	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	AAA_16,GAF,GAF_2,GGDEF,HAMP,HATPase_c,HD,HisKA,PAS_3,PAS_9,PilJ,Pkinase,Response_reg,SpoIIE
k59_1370919_1	1385520.N802_18560	5.38e-21	91.3	COG0178@1|root,COG0178@2|Bacteria,2GJUV@201174|Actinobacteria,4FEX9@85021|Intrasporangiaceae	201174|Actinobacteria	L	ABC transporter	uvrA2	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
k59_1370919_2	1206744.BAGL01000003_gene3475	1.09e-81	243.0	COG0346@1|root,COG0346@2|Bacteria,2IHYP@201174|Actinobacteria,4G1AU@85025|Nocardiaceae	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
k59_1261108_1	1111479.AXAR01000004_gene2121	1.92e-15	81.3	COG4365@1|root,COG4365@2|Bacteria,1TQ2P@1239|Firmicutes,4HA2Z@91061|Bacilli,279YT@186823|Alicyclobacillaceae	91061|Bacilli	S	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH	bshC	-	-	ko:K22136	-	-	-	-	ko00000	-	-	-	BshC
k59_369263_1	1121448.DGI_2643	1.1e-104	317.0	COG1861@1|root,COG1861@2|Bacteria,1QU5J@1224|Proteobacteria,43EAS@68525|delta/epsilon subdivisions,2X7TI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Transposase DDE domain group 1	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k59_928191_1	1203605.HMPREF1531_01506	2.81e-15	73.6	COG0745@1|root,COG0745@2|Bacteria,2GK5S@201174|Actinobacteria,4DN7R@85009|Propionibacteriales	201174|Actinobacteria	T	Transcriptional regulatory protein, C terminal	resD	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
k59_91333_1	948106.AWZT01000001_gene4985	4.46e-30	123.0	COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2VH59@28216|Betaproteobacteria,1K2QQ@119060|Burkholderiaceae	28216|Betaproteobacteria	I	carboxylase	accA1	GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576	6.4.1.3,6.4.1.4	ko:K01965,ko:K01968	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00036,M00373,M00741	R01859,R04138	RC00097,RC00367,RC00609,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
k59_1536514_1	553385.JEMF01000081_gene2030	6.72e-27	111.0	COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,1RPRD@1236|Gammaproteobacteria,1XJ8F@135619|Oceanospirillales	135619|Oceanospirillales	C	Zinc-binding dehydrogenase	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
k59_1536514_2	1163407.UU7_12409	9.52e-32	125.0	COG4805@1|root,COG4805@2|Bacteria,1R5EP@1224|Proteobacteria,1RRS6@1236|Gammaproteobacteria,1X5GF@135614|Xanthomonadales	135614|Xanthomonadales	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
k59_35430_1	234621.RER_11700	9.12e-70	226.0	COG0501@1|root,COG0501@2|Bacteria,2GKJQ@201174|Actinobacteria,4FY5K@85025|Nocardiaceae	201174|Actinobacteria	O	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
k59_425033_1	1242864.D187_001974	3.11e-23	103.0	COG0030@1|root,COG0030@2|Bacteria,1QXTN@1224|Proteobacteria	1224|Proteobacteria	J	Nodulation protein S (NodS)	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,Methyltransf_23
k59_1646293_1	583345.Mmol_0170	9.94e-10	59.3	COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,2VH47@28216|Betaproteobacteria,2KMF6@206350|Nitrosomonadales	206350|Nitrosomonadales	E	TIGRFAM argininosuccinate lyase	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
k59_1646293_2	671143.DAMO_0085	1.56e-181	514.0	COG0137@1|root,COG0137@2|Bacteria,2NP01@2323|unclassified Bacteria	2|Bacteria	E	Arginosuccinate synthase	argG	GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iJN678.argG,iSB619.SA_RS04675	Arginosuc_synth
k59_146239_1	1185876.BN8_02100	3.69e-09	58.2	COG0730@1|root,COG0730@2|Bacteria,4PKBI@976|Bacteroidetes,47K77@768503|Cytophagia	976|Bacteroidetes	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
k59_146239_2	1236976.JCM16418_1017	1.47e-09	61.6	COG1030@1|root,COG1030@2|Bacteria,1TR54@1239|Firmicutes,4H9P9@91061|Bacilli,26T8S@186822|Paenibacillaceae	91061|Bacilli	O	serine protease	yqeZ	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	NfeD,SDH_sah
k59_1203439_1	1449063.JMLS01000023_gene2927	4.57e-10	65.9	COG3850@1|root,COG5002@1|root,COG3850@2|Bacteria,COG5002@2|Bacteria,1TPSK@1239|Firmicutes,4HD2N@91061|Bacilli,26R1F@186822|Paenibacillaceae	91061|Bacilli	T	Histidine kinase	lisK	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
k59_1536525_1	326427.Cagg_2702	5.36e-121	369.0	COG0205@1|root,COG0205@2|Bacteria,2G62R@200795|Chloroflexi,375FT@32061|Chloroflexia	32061|Chloroflexia	H	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	-	-	2.7.1.11	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
k59_1203445_1	1429046.RR21198_2644	2.82e-20	90.9	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,2GK8E@201174|Actinobacteria,4FWJH@85025|Nocardiaceae	201174|Actinobacteria	C	NADH:flavin oxidoreductase / NADH oxidase family	fadH	-	1.3.1.34	ko:K00219	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_FMN,Pyr_redox_2
k59_1203445_2	311402.Avi_0448	8.35e-31	116.0	COG1957@1|root,COG1957@2|Bacteria,1MUIW@1224|Proteobacteria,2TSXQ@28211|Alphaproteobacteria,4B7K7@82115|Rhizobiaceae	28211|Alphaproteobacteria	F	Nucleoside	rihA	GO:0003674,GO:0003824,GO:0006139,GO:0006152,GO:0006213,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008477,GO:0008655,GO:0009056,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009164,GO:0009165,GO:0009435,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0018130,GO:0019357,GO:0019358,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019439,GO:0019637,GO:0019674,GO:0034356,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0043094,GO:0043173,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0045437,GO:0046135,GO:0046483,GO:0046496,GO:0046497,GO:0046700,GO:0050263,GO:0051186,GO:0051188,GO:0055086,GO:0070635,GO:0070636,GO:0071704,GO:0072521,GO:0072523,GO:0072524,GO:0072525,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658	3.2.2.1	ko:K01239	ko00230,ko00760,ko01100,map00230,map00760,map01100	-	R01245,R01273,R01677,R01770,R02143	RC00033,RC00063,RC00122,RC00318,RC00485	ko00000,ko00001,ko01000	-	-	-	IU_nuc_hydro
k59_1536528_1	886293.Sinac_5243	5.07e-121	353.0	COG0115@1|root,COG0115@2|Bacteria,2J2GT@203682|Planctomycetes	203682|Planctomycetes	H	Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase	-	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
k59_35443_1	1121403.AUCV01000008_gene1495	6.32e-60	192.0	COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,42N7Q@68525|delta/epsilon subdivisions,2WJ1I@28221|Deltaproteobacteria,2MIE0@213118|Desulfobacterales	28221|Deltaproteobacteria	K	transcriptional regulatory protein	yebC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
k59_1148916_1	671143.DAMO_0332	4.42e-98	298.0	COG0014@1|root,COG0014@2|Bacteria,2NQM3@2323|unclassified Bacteria	2|Bacteria	E	Aldehyde dehydrogenase family	proA	GO:0003674,GO:0003824,GO:0004350,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0018130,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	iLJ478.TM0293,iYO844.BSU13130	Aldedh
k59_1148916_2	1034345.CAEM01000018_gene353	3.09e-16	78.6	COG1057@1|root,COG1713@1|root,COG1057@2|Bacteria,COG1713@2|Bacteria,2GMFZ@201174|Actinobacteria,4CVT0@84998|Coriobacteriia	84998|Coriobacteriia	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like,HD
k59_35450_1	1121930.AQXG01000011_gene1720	2.65e-60	203.0	COG2132@1|root,COG2132@2|Bacteria,4NE3N@976|Bacteroidetes	976|Bacteroidetes	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
k59_814305_1	926569.ANT_01770	9.56e-56	187.0	COG0438@1|root,COG0438@2|Bacteria,2G6KX@200795|Chloroflexi	200795|Chloroflexi	M	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4
k59_146273_1	309807.SRU_0982	6.45e-63	210.0	COG5505@1|root,COG5505@2|Bacteria,4NE2H@976|Bacteroidetes,1FJQG@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Protein of unknown function (DUF819)	-	-	-	-	-	-	-	-	-	-	-	-	DUF819
k59_1705810_1	671143.DAMO_1520	1.63e-52	173.0	COG0569@1|root,COG0569@2|Bacteria,2NPXT@2323|unclassified Bacteria	2|Bacteria	P	TrkA-N domain	ceoB	-	-	ko:K03499,ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6,2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
k59_869248_1	1122138.AQUZ01000004_gene888	4.53e-136	401.0	COG1053@1|root,COG1053@2|Bacteria,2GJ45@201174|Actinobacteria,4DPTE@85009|Propionibacteriales	201174|Actinobacteria	C	PFAM fumarate reductase succinate dehydrogenase flavoprotein domain protein	frdA	GO:0000104,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006091,GO:0006113,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016627,GO:0022900,GO:0032991,GO:0044237,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045273,GO:0045274,GO:0045283,GO:0045284,GO:0045333,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803	1.3.5.1,1.3.5.4,1.4.3.16	ko:K00239,ko:K00244,ko:K00278	ko00020,ko00190,ko00250,ko00620,ko00650,ko00720,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,ko05134,map00020,map00190,map00250,map00620,map00650,map00720,map00760,map01100,map01110,map01120,map01130,map01200,map02020,map05134	M00009,M00011,M00115,M00149,M00150,M00173,M00374,M00376	R00357,R00481,R02164	RC00006,RC00045,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1552	FAD_binding_2,Succ_DH_flav_C
k59_758565_1	1116472.MGMO_157c00100	4.57e-41	152.0	2EF1J@1|root,338UN@2|Bacteria,1P071@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1148928_1	1205680.CAKO01000038_gene1661	2.06e-88	268.0	COG4608@1|root,COG4608@2|Bacteria,1NU4K@1224|Proteobacteria,2TQTV@28211|Alphaproteobacteria,2JPRD@204441|Rhodospirillales	204441|Rhodospirillales	E	Belongs to the ABC transporter superfamily	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,oligo_HPY
k59_989806_1	1408445.JHXP01000020_gene1914	2.79e-19	87.0	arCOG09452@1|root,335JP@2|Bacteria,1RJGH@1224|Proteobacteria,1SEKG@1236|Gammaproteobacteria,1JEW2@118969|Legionellales	118969|Legionellales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_207726_1	472759.Nhal_1408	3.2e-35	137.0	COG0577@1|root,COG0577@2|Bacteria,1MVCT@1224|Proteobacteria,1RNP1@1236|Gammaproteobacteria,1WWFF@135613|Chromatiales	135613|Chromatiales	V	ABC-type transport system, involved in lipoprotein release, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_543102_1	477974.Daud_1191	6.5e-33	132.0	COG0147@1|root,COG0147@2|Bacteria,1TQAP@1239|Firmicutes,24946@186801|Clostridia,260ZU@186807|Peptococcaceae	186801|Clostridia	E	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	2.6.1.85,4.1.3.27	ko:K01657,ko:K01665	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716	RC00010,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
k59_42036_1	1382356.JQMP01000003_gene1449	9.72e-06	48.5	COG0577@1|root,COG0577@2|Bacteria,2G65B@200795|Chloroflexi	200795|Chloroflexi	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_42036_2	1496688.ER33_02160	3.23e-20	91.7	COG0577@1|root,COG0577@2|Bacteria,1G0A8@1117|Cyanobacteria,22THJ@167375|Cyanobium	1117|Cyanobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_207737_1	37919.EP51_38775	2.04e-55	182.0	COG0638@1|root,COG0638@2|Bacteria,2GKZ1@201174|Actinobacteria,4FU63@85025|Nocardiaceae	201174|Actinobacteria	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	prcA	GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005839,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010498,GO:0016020,GO:0016787,GO:0019538,GO:0019773,GO:0019941,GO:0030163,GO:0030312,GO:0032991,GO:0040007,GO:0043170,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0051603,GO:0051704,GO:0070003,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
k59_765007_2	378806.STAUR_6048	2.75e-31	116.0	COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,42NNS@68525|delta/epsilon subdivisions,2WMS3@28221|Deltaproteobacteria,2YVCJ@29|Myxococcales	28221|Deltaproteobacteria	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
k59_652431_1	1047013.AQSP01000142_gene193	3.64e-51	177.0	COG0534@1|root,COG0534@2|Bacteria,2NPFE@2323|unclassified Bacteria	2|Bacteria	V	Mate efflux family protein	-	-	-	-	-	-	-	-	-	-	-	-	ANKH,MatE
k59_1268769_1	1121447.JONL01000022_gene3718	1.24e-15	72.0	2B9ZZ@1|root,323DM@2|Bacteria,1MZ6J@1224|Proteobacteria,42WB2@68525|delta/epsilon subdivisions,2WWEJ@28221|Deltaproteobacteria,2MFC3@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	COG NOG15344 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_207748_1	381666.H16_A1410	3.8e-21	92.0	COG1024@1|root,COG1024@2|Bacteria,1N817@1224|Proteobacteria,2VKSK@28216|Betaproteobacteria,1KCIM@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Enoyl-CoA hydratase/isomerase	boxC	-	4.1.2.44	ko:K15513	ko00362,map00362	-	R09556	RC03426	ko00000,ko00001,ko01000	-	-	-	ECH_1
k59_207748_2	76114.ebA5278	3e-28	110.0	COG0703@1|root,COG1396@1|root,COG0703@2|Bacteria,COG1396@2|Bacteria,1MX66@1224|Proteobacteria,2VK91@28216|Betaproteobacteria,2KYFD@206389|Rhodocyclales	206389|Rhodocyclales	F	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	bzdR	-	-	ko:K15546	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3,SKI
k59_431915_1	1379270.AUXF01000006_gene109	8.69e-85	272.0	COG0539@1|root,COG2183@1|root,COG0539@2|Bacteria,COG2183@2|Bacteria,1ZSKI@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	-	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
k59_1046105_1	1158146.KB907123_gene712	5.28e-31	125.0	COG0438@1|root,COG0561@1|root,COG0438@2|Bacteria,COG0561@2|Bacteria,1MWVX@1224|Proteobacteria,1RSR5@1236|Gammaproteobacteria,1WWRD@135613|Chromatiales	135613|Chromatiales	M	HAD-superfamily hydrolase, subfamily IIB	-	-	2.4.1.14	ko:K00696	ko00500,ko01100,map00500,map01100	-	R00766	RC00005,RC00028,RC02748	ko00000,ko00001,ko01000	-	GT4	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1,S6PP,Sucrose_synth
k59_98614_1	706587.Desti_2503	1.17e-124	380.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,42PRE@68525|delta/epsilon subdivisions,2WJRD@28221|Deltaproteobacteria,2MRGT@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_207766_1	748658.KB907316_gene433	1.73e-15	81.3	COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,1RMTM@1236|Gammaproteobacteria,1WWYB@135613|Chromatiales	135613|Chromatiales	M	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
k59_1489609_1	1121430.JMLG01000026_gene26	6e-26	112.0	COG0550@1|root,COG0550@2|Bacteria,1TPUS@1239|Firmicutes,248MG@186801|Clostridia,260E9@186807|Peptococcaceae	186801|Clostridia	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
k59_1099953_1	269799.Gmet_2169	7.54e-41	149.0	COG0438@1|root,COG0438@2|Bacteria,1MUYN@1224|Proteobacteria,42S1I@68525|delta/epsilon subdivisions,2WQA1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Domain of unknown function (DUF1972)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1972
k59_1712712_1	485913.Krac_9271	3.15e-68	222.0	2DBVK@1|root,2ZBBH@2|Bacteria,2G7SF@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_207784_1	861299.J421_1876	1.72e-147	431.0	COG3386@1|root,COG3386@2|Bacteria	2|Bacteria	G	gluconolactonase activity	-	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	SGL
k59_1099961_1	1382304.JNIL01000001_gene2819	8.03e-07	55.8	COG0425@1|root,COG0607@1|root,COG0425@2|Bacteria,COG0607@2|Bacteria,1V1GU@1239|Firmicutes,4HFR8@91061|Bacilli	91061|Bacilli	OP	Belongs to the sulfur carrier protein TusA family	yrkF	-	-	-	-	-	-	-	-	-	-	-	Rhodanese,TusA
k59_652487_1	1122603.ATVI01000005_gene2872	6.55e-37	143.0	COG2199@1|root,COG3829@1|root,COG3706@2|Bacteria,COG3829@2|Bacteria,1MVCZ@1224|Proteobacteria,1RS2H@1236|Gammaproteobacteria,1X5TB@135614|Xanthomonadales	135614|Xanthomonadales	T	Diguanylate cyclase	-	-	2.7.7.65	ko:K13069	-	-	R08057	-	ko00000,ko01000	-	-	-	GGDEF,Protoglobin
k59_98649_1	880073.Calab_1874	1.52e-76	247.0	COG0481@1|root,COG0481@2|Bacteria,2NNXG@2323|unclassified Bacteria	2|Bacteria	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
k59_1542719_1	991905.SL003B_1768	4.44e-25	105.0	COG1028@1|root,COG1028@2|Bacteria,1MU2T@1224|Proteobacteria,2TSDG@28211|Alphaproteobacteria,4BQQW@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	1.1.1.100,1.1.1.36,1.1.1.401	ko:K00023,ko:K00059,ko:K07535,ko:K21883	ko00051,ko00061,ko00333,ko00362,ko00630,ko00650,ko00780,ko01040,ko01100,ko01120,ko01130,ko01200,ko01212,ko01220,map00051,map00061,map00333,map00362,map00630,map00650,map00780,map01040,map01100,map01120,map01130,map01200,map01212,map01220	M00083,M00373,M00540,M00572	R01779,R01977,R04533,R04534,R04536,R04543,R04566,R04953,R04964,R05582,R07759,R07763,R10116,R10120,R11339,R11671	RC00029,RC00089,RC00103,RC00117,RC00154	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
k59_489805_1	926550.CLDAP_28240	6.15e-91	271.0	COG0235@1|root,COG0235@2|Bacteria,2G63H@200795|Chloroflexi	200795|Chloroflexi	G	Class II Aldolase and Adducin N-terminal domain	-	-	5.1.3.4	ko:K03077	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	M00550	R05850	RC01479	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase_II
k59_207800_1	1379270.AUXF01000002_gene1819	1.11e-70	236.0	COG0188@1|root,COG0188@2|Bacteria,1ZTFF@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_42123_1	1469245.JFBG01000001_gene532	1.43e-38	136.0	COG1132@1|root,COG1132@2|Bacteria,1MX5V@1224|Proteobacteria,1RY02@1236|Gammaproteobacteria,1WXG2@135613|Chromatiales	135613|Chromatiales	V	(ABC) transporter	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_489818_2	744980.TRICHSKD4_2035	3.08e-13	68.6	COG1952@1|root,COG1952@2|Bacteria,1RI75@1224|Proteobacteria,2UBTB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	U	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA	secB	GO:0002790,GO:0006457,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705	-	ko:K03071	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03110	3.A.5	-	-	SecB
k59_598055_1	266835.14022958	8.56e-121	348.0	COG0450@1|root,COG0450@2|Bacteria,1MX2B@1224|Proteobacteria,2TT09@28211|Alphaproteobacteria,43R7H@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	O	C-terminal domain of 1-Cys peroxiredoxin	-	-	-	-	-	-	-	-	-	-	-	-	1-cysPrx_C,AhpC-TSA
k59_1100012_1	1144275.COCOR_07824	0.000333	45.8	COG0596@1|root,COG0596@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on ester bonds	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
k59_1100012_2	69014.TK1693	1.86e-22	92.8	COG2151@1|root,arCOG01845@2157|Archaea,2Y0P6@28890|Euryarchaeota,243HE@183968|Thermococci	183968|Thermococci	S	Pfam:DUF59	-	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
k59_711653_1	883.DvMF_2986	1.85e-16	84.0	COG0642@1|root,COG2202@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WIR4@28221|Deltaproteobacteria,2M7T3@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,Hpt,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
k59_42157_1	177437.HRM2_36880	3.45e-05	52.8	COG1344@1|root,COG1344@2|Bacteria,1MV1N@1224|Proteobacteria,42MX8@68525|delta/epsilon subdivisions,2WJRC@28221|Deltaproteobacteria,2MISQ@213118|Desulfobacterales	28221|Deltaproteobacteria	N	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella	-	-	-	ko:K02406	ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_IN,Flagellin_N
k59_821373_1	1382356.JQMP01000001_gene884	1.83e-18	83.6	COG0446@1|root,COG0446@2|Bacteria,2G6GM@200795|Chloroflexi,27XNV@189775|Thermomicrobia	200795|Chloroflexi	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_1100023_1	309800.C498_08495	2.16e-25	105.0	COG0604@1|root,arCOG01458@2157|Archaea,2XU0Q@28890|Euryarchaeota,23SPC@183963|Halobacteria	183963|Halobacteria	C	COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases	qor1	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_1542782_1	926550.CLDAP_10690	4.81e-85	265.0	COG3552@1|root,COG4372@1|root,COG3552@2|Bacteria,COG4372@2|Bacteria,2G60I@200795|Chloroflexi	200795|Chloroflexi	S	PFAM VWA containing CoxE family protein	-	-	-	ko:K07161	-	-	-	-	ko00000	-	-	-	VWA_CoxE
k59_1712784_1	929558.SMGD1_2606	4.37e-27	114.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,42N2G@68525|delta/epsilon subdivisions,2YP81@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	I	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
k59_1325633_2	489825.LYNGBM3L_14880	4.27e-06	50.8	COG5126@1|root,COG5126@2|Bacteria,1G7DT@1117|Cyanobacteria,1HBQS@1150|Oscillatoriales	1117|Cyanobacteria	DTZ	EF hand	-	-	-	-	-	-	-	-	-	-	-	-	EF-hand_5
k59_1491788_1	1123023.JIAI01000007_gene1963	1.41e-67	230.0	COG0404@1|root,COG0446@1|root,COG4583@1|root,COG0404@2|Bacteria,COG0446@2|Bacteria,COG4583@2|Bacteria,2GMBK@201174|Actinobacteria,4E081@85010|Pseudonocardiales	201174|Actinobacteria	E	Belongs to the GcvT family	-	-	1.5.3.1	ko:K00302	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	FAD_oxidored,Fer2_4,GCV_T,GCV_T_C,Pyr_redox_2
k59_324663_1	1133850.SHJG_1748	2.66e-07	58.2	COG2203@1|root,COG3162@1|root,COG3835@1|root,COG2203@2|Bacteria,COG3162@2|Bacteria,COG3835@2|Bacteria,2I3S0@201174|Actinobacteria	201174|Actinobacteria	T	Pfam GAF	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HTH_30
k59_44154_1	56110.Oscil6304_0325	1.85e-32	129.0	COG0606@1|root,COG0606@2|Bacteria,1G0K1@1117|Cyanobacteria,1H6YU@1150|Oscillatoriales	1117|Cyanobacteria	O	PFAM Magnesium chelatase, subunit ChlI	comM	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
k59_766987_1	1121904.ARBP01000044_gene2069	3.9e-27	110.0	COG0457@1|root,COG0457@2|Bacteria,4PP65@976|Bacteroidetes	976|Bacteroidetes	S	Peptidase family M49	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M49
k59_766987_2	929562.Emtol_3679	9.29e-28	111.0	COG3844@1|root,COG3844@2|Bacteria,4NECS@976|Bacteroidetes,47KPP@768503|Cytophagia	976|Bacteroidetes	E	Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively	kynU	-	3.7.1.3	ko:K01556	ko00380,ko01100,map00380,map01100	M00038	R00987,R02668,R03936	RC00284,RC00415	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5
k59_1544667_1	887898.HMPREF0551_0629	9.46e-16	81.6	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VI4Q@28216|Betaproteobacteria,1K1RF@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Belongs to the peptidase S1C family	mucD	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
k59_1434975_1	1382356.JQMP01000003_gene2064	1.13e-85	271.0	COG0154@1|root,COG0154@2|Bacteria,2G7KI@200795|Chloroflexi,27YVS@189775|Thermomicrobia	189775|Thermomicrobia	J	Amidase	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
k59_1047971_1	268739.Nmlp_1819	1.01e-08	61.2	COG0517@1|root,arCOG00607@2157|Archaea,2XTWV@28890|Euryarchaeota,23SM6@183963|Halobacteria	183963|Halobacteria	S	Belongs to the peptidase M50B family	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Peptidase_M50
k59_1380370_1	344747.PM8797T_17534	3.09e-45	168.0	COG5434@1|root,COG5434@2|Bacteria	2|Bacteria	M	polygalacturonase activity	MA20_15840	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Pectate_lyase_3
k59_1271022_1	1122194.AUHU01000016_gene1874	1.03e-127	379.0	COG3534@1|root,COG3534@2|Bacteria,1PPWJ@1224|Proteobacteria,1RQ0J@1236|Gammaproteobacteria,465P4@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	Alpha-L-arabinofuranosidase C-terminus	abfA	-	3.2.1.55	ko:K01209	ko00520,map00520	-	R01762	-	ko00000,ko00001,ko01000	-	GH51	-	Alpha-L-AF_C
k59_44192_1	886293.Sinac_1569	3.25e-106	321.0	COG0499@1|root,COG0499@2|Bacteria,2IXKQ@203682|Planctomycetes	203682|Planctomycetes	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
k59_1325684_1	298655.KI912267_gene6875	1.28e-06	52.4	COG0147@1|root,COG0147@2|Bacteria,2GN7D@201174|Actinobacteria,4ERUR@85013|Frankiales	201174|Actinobacteria	EH	PFAM chorismate	pabB	-	2.6.1.85,4.1.3.38	ko:K01665,ko:K03342	ko00790,map00790	-	R01716,R05553	RC00010,RC01418,RC01843,RC02148	ko00000,ko00001,ko01000,ko01007	-	-	-	Chorismate_bind
k59_1102120_1	383372.Rcas_2438	4.19e-26	105.0	COG4948@1|root,COG4948@2|Bacteria,2G704@200795|Chloroflexi,3771P@32061|Chloroflexia	32061|Chloroflexia	H	Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB)	menC	-	4.2.1.113	ko:K02549	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R04031	RC01053	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
k59_1102120_2	926569.ANT_14000	3.02e-21	90.1	COG1933@1|root,COG1933@2|Bacteria	2|Bacteria	L	exodeoxyribonuclease I activity	-	-	-	-	-	-	-	-	-	-	-	-	Band_7_1,DZR,PLDc_N,zf-ribbon_3,zinc_ribbon_2
k59_545354_1	316274.Haur_2640	1.57e-30	125.0	COG1196@1|root,COG1196@2|Bacteria,2G64A@200795|Chloroflexi,3758F@32061|Chloroflexia	32061|Chloroflexia	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
k59_156024_1	443152.MDG893_15140	8.49e-16	73.9	2C7PQ@1|root,2ZQ6K@2|Bacteria,1P6IB@1224|Proteobacteria,1SUT2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_156024_2	443152.MDG893_15120	2.41e-67	221.0	COG0028@1|root,COG0028@2|Bacteria,1MX3Q@1224|Proteobacteria,1RZ17@1236|Gammaproteobacteria	1236|Gammaproteobacteria	EH	COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_1102148_1	1191523.MROS_1839	0.000184	48.5	COG2020@1|root,COG2020@2|Bacteria	2|Bacteria	O	methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
k59_1544732_1	551275.KB899544_gene1596	1.03e-21	99.0	COG1075@1|root,COG1075@2|Bacteria,1R5PF@1224|Proteobacteria	1224|Proteobacteria	S	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_5,DUF413,DUF915,LCAT,PGAP1
k59_714205_1	331869.BAL199_11126	3.89e-23	93.2	COG1952@1|root,COG1952@2|Bacteria,1RI75@1224|Proteobacteria,2UBTB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	U	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA	secB	GO:0002790,GO:0006457,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705	-	ko:K03071	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03110	3.A.5	-	-	SecB
k59_714205_2	1054213.HMPREF9946_05051	2.91e-29	111.0	COG0847@1|root,COG0847@2|Bacteria,1MV8Z@1224|Proteobacteria,2TTFF@28211|Alphaproteobacteria,2JPQX@204441|Rhodospirillales	204441|Rhodospirillales	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease	dnaQ	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
k59_1655863_1	1206726.BAFV01000037_gene2434	9.53e-30	122.0	COG0604@1|root,COG3321@1|root,COG0604@2|Bacteria,COG3321@2|Bacteria,2H477@201174|Actinobacteria,4FU0A@85025|Nocardiaceae	201174|Actinobacteria	Q	Acyl transferase domain in polyketide synthase (PKS) enzymes.	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N,Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
k59_600048_1	478801.Ksed_01550	4.79e-24	105.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,2GKAX@201174|Actinobacteria,1ZVEQ@145357|Dermacoccaceae	201174|Actinobacteria	H	Riboflavin biosynthesis protein RibD	ribD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0016020,GO:0016070,GO:0034641,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
k59_1491884_1	935863.AWZR01000003_gene2764	1.03e-80	254.0	COG2723@1|root,COG2723@2|Bacteria,1MWG6@1224|Proteobacteria,1RMM2@1236|Gammaproteobacteria,1X3QG@135614|Xanthomonadales	135614|Xanthomonadales	G	COG2723 Beta-glucosidase 6-phospho-beta-glucosidase beta- galactosidase	-	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1
k59_1380441_1	999413.HMPREF1094_01045	3.5e-51	168.0	COG0041@1|root,COG0041@2|Bacteria,1V1MV@1239|Firmicutes,3VQ15@526524|Erysipelotrichia	526524|Erysipelotrichia	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	-	-	-	-	-	-	-	-	-	-	AIRC
k59_1380441_2	765912.Thimo_0760	3.87e-09	57.4	COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,1RNNY@1236|Gammaproteobacteria,1WVZH@135613|Chromatiales	135613|Chromatiales	F	SAICAR synthetase	purC	-	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
k59_1380446_1	639030.JHVA01000001_gene271	2.16e-61	198.0	COG0581@1|root,COG0581@2|Bacteria,3Y3JF@57723|Acidobacteria,2JHVP@204432|Acidobacteriia	204432|Acidobacteriia	P	Phosphate transport system permease protein PstA	-	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
k59_1380446_2	644966.Tmar_1646	2e-06	49.3	COG1117@1|root,COG1117@2|Bacteria,1TP1M@1239|Firmicutes,247RD@186801|Clostridia,3WCRK@538999|Clostridiales incertae sedis	186801|Clostridia	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
k59_1544765_1	315750.BPUM_3031	1.32e-35	139.0	COG0557@1|root,COG0557@2|Bacteria,1TQ1G@1239|Firmicutes,4HBBH@91061|Bacilli,1ZBDP@1386|Bacillus	91061|Bacilli	K	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
k59_767096_1	1255043.TVNIR_1301	2.33e-38	139.0	COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,1RZYT@1236|Gammaproteobacteria,1WY5J@135613|Chromatiales	135613|Chromatiales	O	Peptidase M48	-	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
k59_1158700_1	880072.Desac_1519	3.17e-46	168.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,42KZ9@68525|delta/epsilon subdivisions,2WJBC@28221|Deltaproteobacteria,2MR01@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_1767353_1	378806.STAUR_6994	4.8e-47	167.0	COG0402@1|root,COG0402@2|Bacteria,1MUFE@1224|Proteobacteria,43AI0@68525|delta/epsilon subdivisions,2X5Y7@28221|Deltaproteobacteria,2YURU@29|Myxococcales	28221|Deltaproteobacteria	F	Amidohydrolase family	hutF	-	3.5.3.13	ko:K05603	ko00340,map00340	-	R02286	RC00682	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
k59_654694_1	379066.GAU_3001	6.7e-28	114.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,1ZUC3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
k59_1396602_2	671143.DAMO_2334	3.03e-78	239.0	COG1403@1|root,COG1403@2|Bacteria,2NPJD@2323|unclassified Bacteria	2|Bacteria	L	HNH endonuclease	mcrA	-	-	-	-	-	-	-	-	-	-	-	HNH,HNH_4,HNH_5
k59_451712_1	571166.KI421509_gene3228	1.24e-21	99.8	COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,2TR2M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
k59_284829_1	1415166.NONO_c31680	1.34e-53	178.0	COG0726@1|root,COG0726@2|Bacteria,2HEQK@201174|Actinobacteria,4FWR1@85025|Nocardiaceae	201174|Actinobacteria	G	Polysaccharide deacetylase	-	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	Polysacc_deac_1
k59_785062_1	1446473.JHWH01000012_gene615	2.76e-13	72.0	COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,2TRPZ@28211|Alphaproteobacteria,2PWMS@265|Paracoccus	28211|Alphaproteobacteria	J	Poly A polymerase head domain	pcnB	-	2.7.7.19,2.7.7.72	ko:K00970,ko:K00974	ko03013,ko03018,map03013,map03018	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	PolyA_pol,PolyA_pol_RNAbd
k59_785062_2	639030.JHVA01000001_gene2944	4.72e-40	142.0	COG1028@1|root,COG1028@2|Bacteria,3Y3FQ@57723|Acidobacteria,2JHPU@204432|Acidobacteriia	204432|Acidobacteriia	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_1341035_1	1144275.COCOR_00703	5.07e-05	48.9	COG0428@1|root,COG0428@2|Bacteria,1R40E@1224|Proteobacteria	1224|Proteobacteria	P	PFAM zinc iron permease	zupT	-	-	ko:K16267	-	-	-	-	ko00000,ko02000	2.A.5.4.11	-	-	Zip
k59_618179_1	1260251.SPISAL_02690	4.83e-09	58.5	COG1600@1|root,COG1600@2|Bacteria,1MV1H@1224|Proteobacteria,1RMD9@1236|Gammaproteobacteria,1WWZ4@135613|Chromatiales	135613|Chromatiales	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	queG	-	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Fer4_16
k59_1618795_1	1469607.KK073768_gene1963	9.5e-28	117.0	COG2199@1|root,COG2202@1|root,COG2203@1|root,COG4251@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3706@2|Bacteria,COG4251@2|Bacteria,1G1Z5@1117|Cyanobacteria,1HKPJ@1161|Nostocales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS_3,Response_reg
k59_840486_1	266117.Rxyl_0743	4.03e-77	243.0	COG0476@1|root,COG0607@1|root,COG0476@2|Bacteria,COG0607@2|Bacteria,2GJB6@201174|Actinobacteria,4CPTD@84995|Rubrobacteria	84995|Rubrobacteria	HP	UBA THIF-type NAD FAD binding	-	-	2.7.7.80,2.8.1.11	ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	Rhodanese,ThiF
k59_451736_1	314230.DSM3645_12606	7.03e-28	117.0	COG2202@1|root,COG4251@1|root,COG2202@2|Bacteria,COG4251@2|Bacteria,2IZ70@203682|Planctomycetes	203682|Planctomycetes	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9
k59_1507849_1	1487923.DP73_07395	1.36e-39	150.0	COG0243@1|root,COG0243@2|Bacteria,1TPZG@1239|Firmicutes,247JV@186801|Clostridia,264KH@186807|Peptococcaceae	186801|Clostridia	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	ko:K00183	-	-	-	-	ko00000	5.A.3	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal
k59_1062988_1	1089550.ATTH01000001_gene950	7.01e-23	103.0	COG0405@1|root,COG0405@2|Bacteria,4NF2H@976|Bacteroidetes,1FJ35@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	E	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k59_340146_1	1184609.KILIM_075_00010	3.03e-05	51.2	COG0500@1|root,COG2226@2|Bacteria,2GP9N@201174|Actinobacteria,4F84P@85018|Dermatophilaceae	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
k59_340146_2	861299.J421_3228	4e-05	43.9	COG1576@1|root,COG1576@2|Bacteria,1ZTQJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA	rlmH	-	2.1.1.177	ko:K00783	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SPOUT_MTase
k59_1174219_1	765420.OSCT_0424	2.94e-56	182.0	COG0283@1|root,COG0283@2|Bacteria,2G6I5@200795|Chloroflexi,375JC@32061|Chloroflexia	32061|Chloroflexia	F	Belongs to the cytidylate kinase family. Type 1 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin
k59_674120_1	314264.ROS217_20047	1.92e-17	81.6	COG5016@1|root,COG5016@2|Bacteria,1QTTG@1224|Proteobacteria,2TXXG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Conserved carboxylase domain	-	-	-	-	-	-	-	-	-	-	-	-	HMGL-like,PYC_OADA
k59_674120_2	1380355.JNIJ01000022_gene3589	1.09e-28	110.0	COG3246@1|root,COG3246@2|Bacteria,1MZTP@1224|Proteobacteria,2TRG7@28211|Alphaproteobacteria,3JS2V@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	beta-keto acid cleavage enzyme	-	-	2.3.1.247	ko:K18013	ko00310,map00310	-	R10564	RC02728,RC03199	ko00000,ko00001,ko01000	-	-	-	BKACE
k59_62408_1	765420.OSCT_1022	9.28e-41	147.0	COG1475@1|root,COG1475@2|Bacteria,2G6EK@200795|Chloroflexi,375IS@32061|Chloroflexia	32061|Chloroflexia	K	PFAM ParB domain protein nuclease	-	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
k59_173571_1	1218074.BAXZ01000028_gene4809	2.12e-31	123.0	COG0477@1|root,COG2814@2|Bacteria,1NGB4@1224|Proteobacteria,2WEBU@28216|Betaproteobacteria,1K022@119060|Burkholderiaceae	28216|Betaproteobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_896555_1	365044.Pnap_0155	1.68e-12	70.9	2E0IF@1|root,32W44@2|Bacteria,1N0RW@1224|Proteobacteria,2VV5A@28216|Betaproteobacteria,4AF67@80864|Comamonadaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_229342_1	580332.Slit_0764	1.36e-57	195.0	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,2VI3Q@28216|Betaproteobacteria,44VFQ@713636|Nitrosomonadales	28216|Betaproteobacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_229342_2	1097668.BYI23_A024510	6.36e-31	112.0	COG0049@1|root,COG0049@2|Bacteria,1MXC8@1224|Proteobacteria,2VQ63@28216|Betaproteobacteria,1K1QQ@119060|Burkholderiaceae	28216|Betaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	-	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
k59_1507898_1	189753.AXAS01000078_gene6582	3.75e-77	241.0	COG2072@1|root,COG2072@2|Bacteria,1MWPJ@1224|Proteobacteria,2TSQA@28211|Alphaproteobacteria,3JT1R@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	ko:K07222	-	-	-	-	ko00000	-	-	-	Pyr_redox_3
k59_229348_1	1095769.CAHF01000021_gene883	1.16e-74	232.0	COG1319@1|root,COG1319@2|Bacteria,1MUDB@1224|Proteobacteria,2VHV8@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Dehydrogenase	coxM	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
k59_896571_1	573370.DMR_43810	5.57e-45	155.0	COG1309@1|root,COG1309@2|Bacteria,1N11B@1224|Proteobacteria,42ZYG@68525|delta/epsilon subdivisions,2WVGK@28221|Deltaproteobacteria,2MB4F@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_1285500_1	1157708.KB907461_gene1583	1.05e-11	66.2	COG3491@1|root,COG3491@2|Bacteria,1MUNT@1224|Proteobacteria,2VPPT@28216|Betaproteobacteria,4AEVR@80864|Comamonadaceae	28216|Betaproteobacteria	C	Belongs to the iron ascorbate-dependent oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy,DIOX_N
k59_1285500_2	1205680.CAKO01000002_gene2556	6.29e-21	90.9	COG0604@1|root,COG0604@2|Bacteria,1MXUX@1224|Proteobacteria,2TTWF@28211|Alphaproteobacteria,2JVF5@204441|Rhodospirillales	204441|Rhodospirillales	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
k59_1507910_2	180281.CPCC7001_2735	3.08e-22	94.7	COG5361@1|root,COG5361@2|Bacteria,1G49Q@1117|Cyanobacteria,22TNQ@167375|Cyanobium	1117|Cyanobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_1230677_1	565045.NOR51B_797	6.68e-23	101.0	COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,1RPJS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	NU	General Secretion Pathway protein	xpsD	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Secretin,Secretin_N
k59_618255_1	1379270.AUXF01000002_gene1345	1.58e-29	121.0	COG0412@1|root,COG0515@1|root,COG1262@1|root,COG0412@2|Bacteria,COG0515@2|Bacteria,COG1262@2|Bacteria,1ZUNU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Serine/Threonine protein kinases, catalytic domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
k59_952039_1	383372.Rcas_2373	8.56e-33	128.0	COG1366@1|root,COG2202@1|root,COG1366@2|Bacteria,COG2202@2|Bacteria,2GA9X@200795|Chloroflexi,376XC@32061|Chloroflexia	32061|Chloroflexia	T	PFAM Sulfate transporter antisigma-factor antagonist STAS	-	-	-	ko:K17763	-	-	-	-	ko00000,ko03021	-	-	-	PAS_3,PAS_4,STAS
k59_507252_2	288000.BBta_5736	4.23e-18	82.8	COG1024@1|root,COG1024@2|Bacteria,1MVEC@1224|Proteobacteria,2TT0I@28211|Alphaproteobacteria,3JUUI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase/isomerase	MA20_37995	-	-	-	-	-	-	-	-	-	-	-	ECH_1
k59_896580_2	883.DvMF_1002	2.38e-60	201.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,42MFC@68525|delta/epsilon subdivisions,2WJ4H@28221|Deltaproteobacteria,2MA1I@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor	bioA	-	2.6.1.62	ko:K00833	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03231	RC00006,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	AAA_26,Aminotran_3
k59_229368_1	1128421.JAGA01000002_gene1480	2.16e-74	233.0	COG1172@1|root,COG1172@2|Bacteria	2|Bacteria	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
k59_229371_1	981383.AEWH01000006_gene3051	1.53e-63	219.0	COG0567@1|root,COG0567@2|Bacteria,1TRDW@1239|Firmicutes,4HAUI@91061|Bacilli	91061|Bacilli	C	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3)	odhA	GO:0003674,GO:0003824,GO:0004591,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016624,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045333,GO:0055114,GO:0071704,GO:0072350,GO:1902494,GO:1990204,GO:1990234	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
k59_1618887_1	266265.Bxe_B1216	2.9e-10	62.8	COG0642@1|root,COG0745@1|root,COG0784@1|root,COG2203@1|root,COG5278@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG5278@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,1K3UA@119060|Burkholderiaceae	28216|Betaproteobacteria	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,CHASE3,GAF_2,HATPase_c,HisKA,PAS,Response_reg
k59_729882_2	552811.Dehly_0552	7.03e-18	78.6	COG0355@1|root,COG0355@2|Bacteria,2G70H@200795|Chloroflexi,34DAK@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	-	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE,ATP-synt_DE_N
k59_119193_1	1128421.JAGA01000001_gene2427	3.84e-20	92.8	COG0007@1|root,COG1587@1|root,COG0007@2|Bacteria,COG1587@2|Bacteria,2NPBQ@2323|unclassified Bacteria	2|Bacteria	H	Tetrapyrrole (Corrin/Porphyrin) Methylases	hemD	GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.1.107,2.5.1.61,4.2.1.75	ko:K01719,ko:K01749,ko:K02303,ko:K13542,ko:K13543	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084,R03165,R03194	RC00003,RC00871,RC01861,RC02317	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS15755,iJN678.hemD	HEM4,TP_methylase
k59_119193_2	59931.WH7805_12038	5.51e-08	54.7	COG0113@1|root,COG0113@2|Bacteria,1G0YH@1117|Cyanobacteria,1GYDI@1129|Synechococcus	1117|Cyanobacteria	H	Belongs to the ALAD family	hemB	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
k59_898158_1	572477.Alvin_1932	9.49e-51	182.0	28HYC@1|root,2Z83T@2|Bacteria,1QEBM@1224|Proteobacteria,1RRCK@1236|Gammaproteobacteria,1WX9U@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_508638_1	671143.DAMO_0170	0.000982	43.9	COG3391@1|root,COG3391@2|Bacteria,2NQ7V@2323|unclassified Bacteria	2|Bacteria	S	Lactonase, 7-bladed beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_D1,Lactonase,Phosphoesterase
k59_63865_1	909943.HIMB100_00006360	6.11e-24	96.7	COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,2TT6A@28211|Alphaproteobacteria,4BQBQ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
k59_63865_2	1229204.AMYY01000022_gene1654	6.06e-23	91.3	COG0099@1|root,COG0099@2|Bacteria,1RD1G@1224|Proteobacteria,2U73D@28211|Alphaproteobacteria,4BQCM@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
k59_119202_1	326427.Cagg_2667	1.87e-24	107.0	COG1366@1|root,COG2202@1|root,COG3829@1|root,COG1366@2|Bacteria,COG2202@2|Bacteria,COG3829@2|Bacteria,2G9FS@200795|Chloroflexi,376CB@32061|Chloroflexia	32061|Chloroflexia	T	PFAM Sulfate transporter antisigma-factor antagonist STAS	-	-	-	ko:K17763	-	-	-	-	ko00000,ko03021	-	-	-	PAS_4,STAS
k59_841974_1	331869.BAL199_12636	6.71e-141	409.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2TSA7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_898170_1	455436.DS989810_gene725	2.55e-09	63.2	COG0775@1|root,COG0775@2|Bacteria,1MY5S@1224|Proteobacteria,1RNSF@1236|Gammaproteobacteria,464F8@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively	mtnN	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008477,GO:0008652,GO:0008782,GO:0008930,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009116,GO:0009119,GO:0009987,GO:0016053,GO:0016787,GO:0016798,GO:0016799,GO:0017144,GO:0019284,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0042802,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046394,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071265,GO:0071267,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901657	3.2.2.9	ko:K01243	ko00270,ko01100,ko01230,map00270,map01100,map01230	M00034,M00609	R00194,R01401	RC00063,RC00318	ko00000,ko00001,ko00002,ko01000	-	-	iPC815.YPO3384,iSBO_1134.SBO_0148	PNP_UDP_1
k59_1454097_1	118161.KB235922_gene2360	1.84e-24	107.0	COG1680@1|root,COG1680@2|Bacteria,1G5M7@1117|Cyanobacteria	1117|Cyanobacteria	V	Beta-lactamase class C	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,DUF3471
k59_175036_1	1150469.RSPPHO_02514	5.56e-43	154.0	COG2317@1|root,COG2317@2|Bacteria,1MW7T@1224|Proteobacteria,2TSMY@28211|Alphaproteobacteria,2JP9Q@204441|Rhodospirillales	204441|Rhodospirillales	E	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues	-	-	3.4.17.19	ko:K01299	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M32
k59_1564939_1	378806.STAUR_8168	6.27e-43	160.0	COG1629@1|root,COG4771@2|Bacteria,1QX6X@1224|Proteobacteria,43BZN@68525|delta/epsilon subdivisions,2X7AF@28221|Deltaproteobacteria,2Z3EM@29|Myxococcales	28221|Deltaproteobacteria	M	CarboxypepD_reg-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Plug
k59_397436_1	644801.Psest_1032	7.5e-69	229.0	COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,1RNHV@1236|Gammaproteobacteria,1YZZJ@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	M	Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)	mrcB	-	2.4.1.129,3.4.16.4	ko:K05365	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase,UB2H
k59_898193_1	42256.RradSPS_0947	6.19e-13	73.2	COG0642@1|root,COG2202@1|root,COG2461@1|root,COG4191@1|root,COG5002@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,COG2461@2|Bacteria,COG4191@2|Bacteria,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	ETR1	-	2.1.1.80,2.7.13.3,3.1.1.61	ko:K02660,ko:K03406,ko:K07716,ko:K13924	ko02020,ko02025,ko02030,ko04112,map02020,map02025,map02030,map04112	M00506,M00511	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035,ko02044	-	-	-	GAF_2,GGDEF,HATPase_c,HisKA,HisKA_2,PAS,PAS_3,PAS_4,PAS_9,Response_reg,dCache_1
k59_898193_2	414684.RC1_1914	4.37e-17	78.6	COG1057@1|root,COG1057@2|Bacteria,1RD0J@1224|Proteobacteria,2U6ZC@28211|Alphaproteobacteria,2JSCY@204441|Rhodospirillales	204441|Rhodospirillales	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
k59_1175789_1	1009370.ALO_15647	2.56e-55	184.0	COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1TQ04@1239|Firmicutes,4H28I@909932|Negativicutes	909932|Negativicutes	M	Belongs to the SIS family. GutQ KpsF subfamily	kdsD	-	5.3.1.13	ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CBS,SIS
k59_508678_1	66875.JODY01000061_gene10	1.99e-11	65.1	COG0500@1|root,COG2226@2|Bacteria,2GRM0@201174|Actinobacteria	201174|Actinobacteria	Q	o-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Dimerisation2,Methyltransf_2
k59_508680_1	1185876.BN8_04256	3.54e-51	179.0	COG0296@1|root,COG1680@1|root,COG0296@2|Bacteria,COG1680@2|Bacteria,4NG6Z@976|Bacteroidetes,47PR8@768503|Cytophagia	976|Bacteroidetes	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	AMPK1_CBM,Beta-lactamase
k59_731393_1	1121004.ATVC01000001_gene347	5.93e-09	62.4	COG0438@1|root,COG0438@2|Bacteria,1NE3V@1224|Proteobacteria,2VJET@28216|Betaproteobacteria,2KQU0@206351|Neisseriales	206351|Neisseriales	M	Glycosyltransferase Family 4	-	-	-	ko:K02844	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT4	-	Glyco_transf_4,Glycos_transf_1
k59_397466_2	546273.VEIDISOL_01232	1.78e-40	140.0	COG0264@1|root,COG0264@2|Bacteria,1TPFJ@1239|Firmicutes,4H35I@909932|Negativicutes	909932|Negativicutes	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
k59_1232387_2	1341646.CBMO010000148_gene4156	1.67e-38	139.0	COG3673@1|root,COG3673@2|Bacteria,2ID7N@201174|Actinobacteria,235R3@1762|Mycobacteriaceae	201174|Actinobacteria	S	Uncharacterized alpha/beta hydrolase domain (DUF2235)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2235
k59_786781_1	867902.Ornrh_0416	4.9e-39	152.0	COG4206@1|root,COG4206@2|Bacteria,4P258@976|Bacteroidetes,1IJ92@117743|Flavobacteriia	976|Bacteroidetes	H	Outer membrane receptor	-	-	-	ko:K21573	-	-	-	-	ko00000,ko02000	1.B.14.6.1	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
k59_675715_1	745718.JADT01000021_gene2658	2.32e-42	159.0	COG2133@1|root,COG3291@1|root,COG5492@1|root,COG2133@2|Bacteria,COG3291@2|Bacteria,COG5492@2|Bacteria,4NEAB@976|Bacteroidetes,1HZEP@117743|Flavobacteriia	976|Bacteroidetes	N	Domain of unknown function (DUF5060)	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6,Collagen_bind_2,DUF5060
k59_1009239_1	1046714.AMRX01000004_gene3348	1.81e-38	131.0	COG0296@1|root,COG0296@2|Bacteria,1N8WX@1224|Proteobacteria,1S8R5@1236|Gammaproteobacteria,467S6@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	Belongs to the glycosyl hydrolase 13 family	-	-	-	-	-	-	-	-	-	-	-	-	AMPK1_CBM,CBM_48
k59_1232406_1	365528.KB891232_gene162	7.27e-94	283.0	COG0500@1|root,COG2226@2|Bacteria,2I3BB@201174|Actinobacteria,4ESXR@85013|Frankiales	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_175084_1	1187851.A33M_3198	5.23e-138	403.0	COG1924@1|root,COG1924@2|Bacteria,1R411@1224|Proteobacteria,2U1DN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Benzoyl-CoA reductase subunit	-	-	1.3.7.8	ko:K04114	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R02451	RC00002,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	BcrAD_BadFG
k59_1120662_1	1121403.AUCV01000032_gene2883	2.75e-15	74.3	COG0328@1|root,COG0328@2|Bacteria,1MZD1@1224|Proteobacteria,42UI6@68525|delta/epsilon subdivisions,2WQSU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Ribonuclease H	rnhA	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RVT_3
k59_23960_1	216142.LT40_04060	5.24e-43	153.0	COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,1RM7M@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
k59_134419_1	448385.sce5502	1.73e-18	90.1	COG0515@1|root,COG1262@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria,1MZ25@1224|Proteobacteria,42PUT@68525|delta/epsilon subdivisions,2WKN0@28221|Deltaproteobacteria,2YVT8@29|Myxococcales	28221|Deltaproteobacteria	KLT	Sulfatase-modifying factor enzyme 1	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	FGE-sulfatase,Pkinase
k59_579098_1	324602.Caur_1817	5.33e-29	110.0	COG0517@1|root,COG0517@2|Bacteria,2G6TI@200795|Chloroflexi,376YQ@32061|Chloroflexia	32061|Chloroflexia	S	amino acid-binding ACT domain protein	-	-	-	ko:K04767	-	-	-	-	ko00000	-	-	-	CBS
k59_1746574_1	272569.rrnAC3446	1.33e-20	92.8	COG1757@1|root,arCOG02009@2157|Archaea,2XTG4@28890|Euryarchaeota,23SPR@183963|Halobacteria	183963|Halobacteria	C	Na H antiporter	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_antiporter
k59_1746574_2	1479237.JMLY01000001_gene1046	3.3e-08	55.8	COG1752@1|root,COG4775@1|root,COG1752@2|Bacteria,COG4775@2|Bacteria,1MUM9@1224|Proteobacteria,1RRSK@1236|Gammaproteobacteria,468GY@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	esterase of the alpha-beta hydrolase superfamily	plpD	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Bac_surface_Ag,POTRA,Patatin
k59_634329_1	395964.KE386496_gene1149	4.43e-78	255.0	COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,2TRI9@28211|Alphaproteobacteria,3N9ZN@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	MMPL family	acrB	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL,cNMP_binding
k59_301936_1	690850.Desaf_3745	5.7e-34	134.0	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,42M5Q@68525|delta/epsilon subdivisions,2WIIX@28221|Deltaproteobacteria,2M88K@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
k59_1191423_1	1262914.BN533_02162	7.57e-64	216.0	COG0210@1|root,COG0210@2|Bacteria,1TPSU@1239|Firmicutes,4H28C@909932|Negativicutes	909932|Negativicutes	L	ATP-dependent DNA helicase	pcrA	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_1079977_1	65393.PCC7424_1974	3.34e-26	108.0	COG3221@1|root,COG3221@2|Bacteria,1G2AZ@1117|Cyanobacteria,3KI0K@43988|Cyanothece	1117|Cyanobacteria	P	ABC transporter, phosphonate, periplasmic substrate-binding protein	-	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	Phosphonate-bd
k59_413040_1	202956.BBNL01000013_gene673	1.46e-52	181.0	COG0696@1|root,COG0696@2|Bacteria,1MUQ1@1224|Proteobacteria,1RMJE@1236|Gammaproteobacteria,3NJ0F@468|Moraxellaceae	1236|Gammaproteobacteria	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmI	GO:0003674,GO:0003824,GO:0004619,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0030145,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046537,GO:0046700,GO:0046872,GO:0046914,GO:0046939,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	iECSE_1348.ECSE_3895,iJN746.PP_5056	Metalloenzyme,Phosphodiest,iPGM_N
k59_969526_2	1220534.B655_0708	9.02e-12	68.6	COG0679@1|root,arCOG04756@2157|Archaea,2XU4B@28890|Euryarchaeota,23P1C@183925|Methanobacteria	183925|Methanobacteria	S	auxin efflux carrier	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
k59_856580_1	391037.Sare_1061	2.88e-14	80.5	COG0043@1|root,COG0043@2|Bacteria,2GKSI@201174|Actinobacteria,4DJK6@85008|Micromonosporales	201174|Actinobacteria	H	3-octaprenyl-4-hydroxybenzoate carboxy-lyase	-	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
k59_579124_1	227377.CBU_0147	2.91e-30	124.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,1RM9M@1236|Gammaproteobacteria,1JD5Q@118969|Legionellales	118969|Legionellales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_469783_1	1499967.BAYZ01000103_gene3715	4.71e-63	205.0	COG5659@1|root,COG5659@2|Bacteria	2|Bacteria	L	transposition	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
k59_134457_1	323097.Nham_1471	9.6e-12	64.3	COG0346@1|root,COG0346@2|Bacteria,1N7R0@1224|Proteobacteria,2U4YP@28211|Alphaproteobacteria,3JWQ0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	MA20_25940	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
k59_134457_2	1038860.AXAP01000045_gene18	1.1e-22	97.4	COG2159@1|root,COG2159@2|Bacteria,1R5PG@1224|Proteobacteria,2U2G9@28211|Alphaproteobacteria,3JWBY@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
k59_1191457_1	1123242.JH636434_gene5469	7.64e-63	200.0	COG2818@1|root,COG2818@2|Bacteria,2IZYU@203682|Planctomycetes	203682|Planctomycetes	L	Methyladenine glycosylase	-	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
k59_301977_1	991905.SL003B_3826	1.27e-95	307.0	COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,2TSVH@28211|Alphaproteobacteria,4BPQH@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Putative amidoligase enzyme (DUF2126)	MA20_16195	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,DUF2126,Transglut_core
k59_746780_1	1231190.NA8A_24089	1.58e-10	60.5	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2TQKF@28211|Alphaproteobacteria,43I6H@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	L	COG4584 Transposase and inactivated derivatives	MA20_10900	-	-	-	-	-	-	-	-	-	-	-	HTH_23,rve
k59_746780_2	1231190.NA8A_24084	6.43e-79	240.0	COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,2TS16@28211|Alphaproteobacteria,43IV6@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	L	IstB-like ATP binding protein	MA20_10895	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
k59_356982_1	926569.ANT_18060	4.28e-83	271.0	COG0166@1|root,COG0176@1|root,COG0166@2|Bacteria,COG0176@2|Bacteria,2G67J@200795|Chloroflexi	200795|Chloroflexi	G	Belongs to the GPI family	pgi	-	2.2.1.2,5.3.1.9	ko:K01810,ko:K13810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00004,M00007,M00114	R01827,R02739,R02740,R03321	RC00376,RC00439,RC00563,RC00604	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI,TAL_FSA
k59_856612_1	309807.SRU_2710	5.06e-58	187.0	COG1225@1|root,COG1225@2|Bacteria	2|Bacteria	O	peroxiredoxin activity	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
k59_856612_2	478741.JAFS01000001_gene2172	1.05e-17	83.6	COG4232@1|root,COG4233@1|root,COG4232@2|Bacteria,COG4233@2|Bacteria,46S6T@74201|Verrucomicrobia,37GGH@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	CO	Disulphide bond corrector protein DsbC	-	-	1.8.1.8	ko:K04084	-	-	-	-	ko00000,ko01000,ko03110	5.A.1.1	-	-	DsbC,DsbD,Thioredoxin_7
k59_245962_1	927677.ALVU02000001_gene1822	6.39e-87	266.0	COG1064@1|root,COG1064@2|Bacteria,1G0B9@1117|Cyanobacteria,1H5JJ@1142|Synechocystis	1117|Cyanobacteria	C	Zinc-binding dehydrogenase	-	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_79260_1	686340.Metal_2972	1.98e-12	65.1	COG1610@1|root,COG1610@2|Bacteria,1RGZS@1224|Proteobacteria,1S61A@1236|Gammaproteobacteria,1XF5X@135618|Methylococcales	135618|Methylococcales	S	Yqey-like protein	-	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
k59_79260_2	500635.MITSMUL_03545	2.29e-05	48.5	COG1193@1|root,COG1193@2|Bacteria,1TP5W@1239|Firmicutes,4H2Z9@909932|Negativicutes	909932|Negativicutes	L	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_V,Smr
k59_691532_1	1121104.AQXH01000001_gene2012	6.18e-58	191.0	COG0492@1|root,COG0492@2|Bacteria,4NDVS@976|Bacteroidetes,1INU1@117747|Sphingobacteriia	976|Bacteroidetes	O	Pyridine nucleotide-disulphide oxidoreductase	ypdA	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_3
k59_79266_1	311403.Arad_7168	3.64e-46	166.0	COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,2TU0R@28211|Alphaproteobacteria,4B7Q4@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
k59_1025662_1	742818.HMPREF9451_01419	5.33e-10	60.8	COG1109@1|root,COG1109@2|Bacteria,2GN87@201174|Actinobacteria,4CUZQ@84998|Coriobacteriia	84998|Coriobacteriia	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_856629_1	1187851.A33M_0466	1.82e-99	298.0	COG0842@1|root,COG0842@2|Bacteria,1MUF4@1224|Proteobacteria,2TRTS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	Transport permease protein	MA20_23385	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
k59_1746646_2	1340493.JNIF01000003_gene3840	1.33e-24	105.0	COG1252@1|root,COG1252@2|Bacteria,3Y308@57723|Acidobacteria	2|Bacteria	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	CBS,Pyr_redox_2,cNMP_binding
k59_79283_1	977880.RALTA_B0370	2.41e-49	167.0	COG0500@1|root,COG2226@2|Bacteria,1REVA@1224|Proteobacteria,2WEYJ@28216|Betaproteobacteria,1KGHX@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Pfam:Methyltransf_26	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_1025674_1	3712.Bo8g105920.1	1.85e-44	164.0	COG0287@1|root,KOG2380@2759|Eukaryota,3893Y@33090|Viridiplantae,3GXZT@35493|Streptophyta	35493|Streptophyta	E	Prephenate dehydrogenase	-	-	3.6.1.1	ko:K01507	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	H_PPase,PDH
k59_357033_1	1528106.JRJE01000004_gene656	3.99e-52	180.0	COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,2TS6F@28211|Alphaproteobacteria,2JQ3D@204441|Rhodospirillales	204441|Rhodospirillales	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI
k59_856650_1	926569.ANT_19900	7.75e-63	206.0	COG0498@1|root,COG0498@2|Bacteria,2G5RK@200795|Chloroflexi	200795|Chloroflexi	E	PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_1080084_1	114615.BRADO0067	1.98e-16	81.3	COG0583@1|root,COG0583@2|Bacteria,1MU2E@1224|Proteobacteria,2TUNU@28211|Alphaproteobacteria,3JQPC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_1635010_1	570952.ATVH01000015_gene1370	1.25e-45	170.0	COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,2JQNY@204441|Rhodospirillales	204441|Rhodospirillales	T	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Guanylate_cyc,SAM_1
k59_190385_1	926569.ANT_10870	5.59e-26	111.0	COG0188@1|root,COG0188@2|Bacteria,2G5Q2@200795|Chloroflexi	200795|Chloroflexi	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_1302846_1	1038859.AXAU01000003_gene6201	2.13e-43	149.0	COG0411@1|root,COG0411@2|Bacteria,1NP6N@1224|Proteobacteria,2U27F@28211|Alphaproteobacteria,3K5XU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
k59_26003_1	1205680.CAKO01000002_gene2612	1.44e-20	95.1	COG0312@1|root,COG0312@2|Bacteria,1MUVW@1224|Proteobacteria,2TSAV@28211|Alphaproteobacteria,2JQGM@204441|Rhodospirillales	204441|Rhodospirillales	S	Zn-dependent proteases and their inactivated homologs	pmbA	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
k59_971656_1	748247.AZKH_1213	0.000137	45.4	2DNEG@1|root,32X40@2|Bacteria,1R7P4@1224|Proteobacteria,2VY6D@28216|Betaproteobacteria	28216|Betaproteobacteria	S	LTXXQ motif family protein	-	-	-	-	-	-	-	-	-	-	-	-	LTXXQ
k59_1471816_1	373994.Riv7116_0780	1.19e-79	258.0	COG1505@1|root,COG1505@2|Bacteria,1G1B7@1117|Cyanobacteria,1HJE5@1161|Nostocales	1117|Cyanobacteria	E	PFAM Prolyl oligopeptidase, N-terminal beta-propeller domain	-	-	3.4.21.26	ko:K01322	ko04614,map04614	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
k59_192264_2	1416752.AYME01000003_gene2298	3.04e-28	112.0	COG1104@1|root,COG1104@2|Bacteria,2GKUT@201174|Actinobacteria,4FMCX@85023|Microbacteriaceae	201174|Actinobacteria	E	Beta-eliminating lyase	iscS1	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
k59_804333_1	218284.CCDN010000005_gene3367	7.56e-23	104.0	COG5002@1|root,COG5002@2|Bacteria,1VUBP@1239|Firmicutes,4HUPW@91061|Bacilli,1ZS15@1386|Bacillus	91061|Bacilli	T	Histidine kinase	kinE	-	2.7.13.3	ko:K13533	ko02020,map02020	M00485	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9
k59_1748572_1	204669.Acid345_0297	6.04e-27	113.0	COG0577@1|root,COG0577@2|Bacteria,3Y6DE@57723|Acidobacteria,2JM90@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_81417_1	1227487.C474_17254	7.57e-72	228.0	COG0492@1|root,arCOG01296@2157|Archaea	2157|Archaea	C	Thioredoxin reductase	-	-	-	ko:K07222	-	-	-	-	ko00000	-	-	-	Pyr_redox_2,Pyr_redox_3
k59_192274_2	1521187.JPIM01000183_gene2471	7.19e-53	177.0	COG0665@1|root,COG0665@2|Bacteria,2G6HT@200795|Chloroflexi,374X0@32061|Chloroflexia	32061|Chloroflexia	E	FAD dependent oxidoreductase	-	-	1.5.3.1	ko:K00303	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO
k59_1582616_1	614083.AWQR01000052_gene3425	1.22e-57	197.0	COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2VJHH@28216|Betaproteobacteria,4AC5B@80864|Comamonadaceae	28216|Betaproteobacteria	I	Carbamoyl-phosphate synthase L chain, ATP-binding	-	-	6.4.1.5	ko:K13777	ko00281,map00281	-	R03494	RC00367,RC00942	ko00000,ko00001,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
k59_526293_1	1123226.KB899301_gene2839	4.08e-08	54.3	COG1048@1|root,COG1048@2|Bacteria,1VTMM@1239|Firmicutes,4HB5N@91061|Bacilli,26R9T@186822|Paenibacillaceae	91061|Bacilli	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	acnA	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k59_526293_2	1089553.Tph_c26220	1.84e-29	114.0	COG5322@1|root,COG5322@2|Bacteria,1TQ2E@1239|Firmicutes,24A1Y@186801|Clostridia,42EUN@68295|Thermoanaerobacterales	186801|Clostridia	S	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1138520_1	987059.RBXJA2T_15018	5.57e-74	234.0	COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,2VHAC@28216|Betaproteobacteria	28216|Betaproteobacteria	E	COG0626 Cystathionine beta-lyases cystathionine gamma-synthases	metC	-	2.5.1.48,4.4.1.1,4.4.1.11,4.4.1.8	ko:K01739,ko:K01758,ko:K01760,ko:K01761	ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017,M00338	R00654,R00782,R00999,R01001,R01286,R01288,R02408,R02508,R03217,R03260,R04770,R04930,R04941,R04944,R04945,R04946,R09366	RC00020,RC00056,RC00069,RC00196,RC00348,RC00382,RC00420,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Cys_Met_Meta_PP
k59_247933_2	1121468.AUBR01000034_gene1374	8.95e-24	102.0	COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,248JC@186801|Clostridia,42FN9@68295|Thermoanaerobacterales	186801|Clostridia	IQ	PFAM AMP-dependent synthetase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
k59_1138525_1	1382304.JNIL01000001_gene1259	2.86e-28	106.0	COG2080@1|root,COG2080@2|Bacteria,1V6HE@1239|Firmicutes,4HHHI@91061|Bacilli,279T5@186823|Alicyclobacillaceae	91061|Bacilli	C	[2Fe-2S] binding domain	pucE	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
k59_1138525_2	101510.RHA1_ro03489	1.19e-17	83.6	COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria,4FV5G@85025|Nocardiaceae	201174|Actinobacteria	C	Dehydrogenase	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_81446_1	1278073.MYSTI_06420	5.22e-79	251.0	COG2719@1|root,COG2719@2|Bacteria,1MW6U@1224|Proteobacteria,42MYY@68525|delta/epsilon subdivisions,2WJ6V@28221|Deltaproteobacteria,2YUGF@29|Myxococcales	28221|Deltaproteobacteria	S	SpoVR like protein	spoVR	-	-	ko:K06415	-	-	-	-	ko00000	-	-	-	SpoVR
k59_415130_1	1267534.KB906758_gene2268	5.42e-26	110.0	COG2272@1|root,COG2272@2|Bacteria,3Y6PV@57723|Acidobacteria,2JKXD@204432|Acidobacteriia	204432|Acidobacteriia	I	Carboxylesterase family	-	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase
k59_748714_2	1191523.MROS_2692	3.09e-05	46.6	COG0058@1|root,COG0058@2|Bacteria	2|Bacteria	G	glycogen phosphorylase activity	malP	-	2.4.1.1,2.4.1.8	ko:K00688,ko:K00691	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R01555,R02111	RC00049	ko00000,ko00001,ko01000	-	GH65,GT35	-	DUF3417,Phosphorylase
k59_748717_1	411464.DESPIG_02498	2.45e-28	112.0	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,42KZM@68525|delta/epsilon subdivisions,2WJGP@28221|Deltaproteobacteria,2M8Q4@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
k59_748717_2	1379270.AUXF01000006_gene61	1.07e-52	179.0	COG1420@1|root,COG1420@2|Bacteria,1ZTER@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA
k59_1082214_1	1157943.KB892705_gene2066	1.98e-40	152.0	COG0286@1|root,COG1002@1|root,COG0286@2|Bacteria,COG1002@2|Bacteria	2|Bacteria	V	DNA modification	-	-	-	-	-	-	-	-	-	-	-	-	N6_Mtase
k59_136593_1	1089550.ATTH01000001_gene1112	4.59e-63	210.0	COG2270@1|root,COG2270@2|Bacteria,4NEKI@976|Bacteroidetes,1FJQB@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	MFS/sugar transport protein	-	-	-	ko:K06902	ko04138,map04138	-	-	-	ko00000,ko00001,ko02000,ko04131	2.A.1.24,9.A.15.1	-	-	ATG22
k59_1193534_1	2002.JOEQ01000005_gene3526	1.05e-34	127.0	2CBRB@1|root,33SV2@2|Bacteria,2IJ64@201174|Actinobacteria,4EJ8Z@85012|Streptosporangiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_804388_1	357808.RoseRS_0964	7.95e-08	54.7	COG0665@1|root,COG0665@2|Bacteria,2G867@200795|Chloroflexi,376MJ@32061|Chloroflexia	32061|Chloroflexia	E	PFAM FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
k59_804388_2	1206737.BAGF01000006_gene415	2.43e-69	217.0	COG2343@1|root,COG2343@2|Bacteria,2IKUM@201174|Actinobacteria,4FX0U@85025|Nocardiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF427)	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_9
k59_472015_1	880072.Desac_2903	9.63e-63	200.0	COG0036@1|root,COG0036@2|Bacteria,1MUZM@1224|Proteobacteria,42NC0@68525|delta/epsilon subdivisions,2WJK9@28221|Deltaproteobacteria,2MQF1@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Ribulose-phosphate 3 epimerase family	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
k59_1193558_1	1114970.PSF113_3656	1e-29	122.0	COG0477@1|root,COG0477@2|Bacteria,1MWXZ@1224|Proteobacteria,1RW6N@1236|Gammaproteobacteria,1YTQ4@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	P	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_136616_2	113395.AXAI01000022_gene3537	2.68e-54	179.0	COG1802@1|root,COG1802@2|Bacteria,1N7GE@1224|Proteobacteria,2TRBH@28211|Alphaproteobacteria,3JUUF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	FCD	MA20_43175	-	-	ko:K11475	-	-	-	-	ko00000,ko03000	-	-	-	FCD,GntR
k59_192359_1	1214101.BN159_4248	3.01e-05	51.2	COG4733@1|root,COG4733@2|Bacteria,2HCWC@201174|Actinobacteria	201174|Actinobacteria	Q	PA14 domain	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,Malectin,PA14
k59_636589_1	1347086.CCBA010000031_gene806	1.24e-29	119.0	COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,1TQCU@1239|Firmicutes,4HB60@91061|Bacilli,1ZBI9@1386|Bacillus	91061|Bacilli	K	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
k59_748761_1	1336208.JADY01000001_gene1219	4.83e-27	114.0	COG0477@1|root,COG0477@2|Bacteria,1QTTP@1224|Proteobacteria,2TVY9@28211|Alphaproteobacteria,2JR3G@204441|Rhodospirillales	204441|Rhodospirillales	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_693747_1	33898.JRHJ01000075_gene2926	1.23e-06	50.1	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the ABC transporter superfamily	-	-	-	ko:K02052	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	ABC_tran,TOBE_2
k59_693747_2	570967.JMLV01000003_gene2102	1.63e-29	119.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQMJ@28211|Alphaproteobacteria,2JRK4@204441|Rhodospirillales	204441|Rhodospirillales	E	TOBE domain	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,TOBE_2
k59_693749_1	1459636.NTE_00079	1.85e-60	209.0	COG1933@1|root,arCOG04447@2157|Archaea,41SYW@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polC	-	2.7.7.7	ko:K02322	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	PolC_DP2
k59_1045639_1	1175306.GWL_08540	2.18e-93	301.0	COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,2VHJV@28216|Betaproteobacteria	28216|Betaproteobacteria	D	FtsK SpoIIIE	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
k59_431390_1	1089550.ATTH01000001_gene329	3.25e-65	207.0	COG0253@1|root,COG0253@2|Bacteria,4NF26@976|Bacteroidetes,1FJ8F@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
k59_489110_1	1122138.AQUZ01000041_gene7242	5.28e-11	66.6	COG1893@1|root,COG1893@2|Bacteria,2I3AM@201174|Actinobacteria,4DUY3@85009|Propionibacteriales	201174|Actinobacteria	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	panE	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
k59_98101_1	688269.Theth_1569	1.33e-68	225.0	COG1894@1|root,COG1894@2|Bacteria,2GCCH@200918|Thermotogae	200918|Thermotogae	C	PFAM Respiratory-chain NADH dehydrogenase domain, 51 kDa subunit	-	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
k59_1045668_1	408672.NBCG_05148	7.02e-25	104.0	28JCJ@1|root,2Z977@2|Bacteria,2HZXV@201174|Actinobacteria,4DUHT@85009|Propionibacteriales	201174|Actinobacteria	S	ABC-2 family transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_3
k59_764563_1	1089552.KI911559_gene1338	1.29e-07	55.5	28WQX@1|root,2ZIQM@2|Bacteria,1R2AP@1224|Proteobacteria,2UGXG@28211|Alphaproteobacteria,2JVXE@204441|Rhodospirillales	204441|Rhodospirillales	S	PilZ domain	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_3,PilZ
k59_764563_2	1121943.KB899990_gene3692	7.89e-17	86.3	COG1215@1|root,COG1215@2|Bacteria,1NQ1J@1224|Proteobacteria,1RYM8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	COG1215 Glycosyltransferases, probably involved in cell wall biogenesis	alg8	-	2.4.1.33	ko:K19290	ko00051,map00051	-	R08692	RC00005	ko00000,ko00001,ko01000,ko01003,ko02000	4.D.1.1.7,4.D.1.1.9	GT2	-	Glyco_tranf_2_3
k59_1432353_2	1565129.JSFF01000004_gene3173	2.89e-36	126.0	COG0278@1|root,COG0278@2|Bacteria,1MZ4V@1224|Proteobacteria,1S640@1236|Gammaproteobacteria,2QBVJ@267890|Shewanellaceae	1236|Gammaproteobacteria	C	Belongs to the glutaredoxin family. Monothiol subfamily	grxD	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0051536,GO:0051537,GO:0051540	-	ko:K07390	-	-	-	-	ko00000,ko03029,ko03110	-	-	iPC815.YPO2383,iYL1228.KPN_01992	Glutaredoxin
k59_1542224_1	986075.CathTA2_1460	4.99e-23	90.5	COG0694@1|root,COG0694@2|Bacteria,1VAAU@1239|Firmicutes,4HKQ8@91061|Bacilli	91061|Bacilli	O	Nitrogen fixation protein NifU	yutI	-	-	-	-	-	-	-	-	-	-	-	NifU
k59_98117_1	1463921.JODF01000003_gene2202	1.78e-39	150.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIRS@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator, SARP family	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,NB-ARC,TPR_12,Trans_reg_C
k59_875902_2	1547437.LL06_15620	4.46e-28	105.0	2E5W4@1|root,330K6@2|Bacteria,1N893@1224|Proteobacteria,2UGUZ@28211|Alphaproteobacteria,43M2X@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	NIPSNAP	-	-	-	-	-	-	-	-	-	-	-	-	NIPSNAP
k59_597575_1	986075.CathTA2_1980	1.14e-37	137.0	COG1489@1|root,COG1489@2|Bacteria,1V1GZ@1239|Firmicutes,4HCPN@91061|Bacilli	91061|Bacilli	S	Belongs to the SfsA family	sfsA	-	-	ko:K06206	-	-	-	-	ko00000	-	-	-	SfsA
k59_489187_1	983920.Y88_1004	3.54e-14	70.5	COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,2TQYF@28211|Alphaproteobacteria,2K0CN@204457|Sphingomonadales	204457|Sphingomonadales	C	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family	sdhB	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_17
k59_1155060_1	1227739.Hsw_1860	6.73e-18	86.3	COG1674@1|root,COG1674@2|Bacteria,4NE86@976|Bacteroidetes,47JI0@768503|Cytophagia	976|Bacteroidetes	D	DNA segregation ATPase FtsK SpoIIIE	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
k59_431456_1	369723.Strop_1654	3.44e-53	185.0	COG0699@1|root,COG0699@2|Bacteria,2GNGP@201174|Actinobacteria,4DB0Z@85008|Micromonosporales	201174|Actinobacteria	S	Dynamin family	-	-	-	-	-	-	-	-	-	-	-	-	Dynamin_N
k59_542689_1	638301.HMPREF0444_0367	1.69e-23	102.0	COG0635@1|root,COG0635@2|Bacteria,1TPES@1239|Firmicutes,4HA60@91061|Bacilli,27H4M@186828|Carnobacteriaceae	91061|Bacilli	H	Involved in the biosynthesis of porphyrin-containing compound	hemN	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
k59_207336_1	1185876.BN8_01977	1.93e-57	196.0	COG0405@1|root,COG0405@2|Bacteria,4NF2H@976|Bacteroidetes,47JRT@768503|Cytophagia	976|Bacteroidetes	E	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k59_1599897_1	1120949.KB903326_gene3097	6.74e-29	115.0	COG0789@1|root,COG4978@1|root,COG0789@2|Bacteria,COG4978@2|Bacteria,2GMG7@201174|Actinobacteria,4D96P@85008|Micromonosporales	201174|Actinobacteria	KT	Bacterial transcription activator, effector binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GyrI-like,MerR_1
k59_989441_1	344747.PM8797T_04830	4.12e-36	136.0	COG0614@1|root,COG0614@2|Bacteria,2J1IR@203682|Planctomycetes	203682|Planctomycetes	P	ABC-type Fe3 -hydroxamate transport system, periplasmic component	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
k59_1432413_1	1040987.AZUY01000013_gene2888	1.07e-08	62.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,2TT3Z@28211|Alphaproteobacteria,43NXW@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_322036_1	313606.M23134_05560	7.14e-94	292.0	COG1053@1|root,COG1053@2|Bacteria,4NFDU@976|Bacteroidetes,47JE5@768503|Cytophagia	976|Bacteroidetes	C	TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein subunit	sdhA	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_764624_1	1459636.NTE_00788	8.51e-78	242.0	COG1060@1|root,arCOG00656@2157|Archaea,41SCN@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnC	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
k59_1377736_2	1211813.CAPH01000017_gene784	8.29e-45	150.0	COG1490@1|root,COG1490@2|Bacteria,4NNFF@976|Bacteroidetes,2FNMW@200643|Bacteroidia,22UH7@171550|Rikenellaceae	976|Bacteroidetes	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	-	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
k59_1099485_1	398525.KB900701_gene6364	2.56e-62	203.0	COG2159@1|root,COG2159@2|Bacteria,1R5PG@1224|Proteobacteria,2U2G9@28211|Alphaproteobacteria,3JWBY@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
k59_324110_1	394.NGR_c35870	2.08e-90	280.0	COG1861@1|root,COG1861@2|Bacteria,1QU5J@1224|Proteobacteria,2U0ZH@28211|Alphaproteobacteria,4BJ1H@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Transposase DDE domain group 1	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k59_599467_1	1038867.AXAY01000015_gene6952	4.43e-13	72.4	COG0715@1|root,COG0715@2|Bacteria,1PKQN@1224|Proteobacteria,2TSRB@28211|Alphaproteobacteria,3JZWP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	4,5-dihydroxyphthalate decarboxylase	-	-	4.1.1.55	ko:K04102	ko00624,ko01100,ko01120,map00624,map01100,map01120	M00623	R01635,R05375	RC00390	ko00000,ko00001,ko00002,ko01000	-	-	-	NMT1
k59_599467_2	266265.Bxe_C0470	1.08e-21	96.3	COG0673@1|root,COG0673@2|Bacteria,1PXC6@1224|Proteobacteria,2WCTQ@28216|Betaproteobacteria,1K6U9@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
k59_1157803_1	1177594.MIC448_460019	5.89e-10	56.2	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE,PAS_9
k59_1655109_1	1317118.ATO8_12866	5.17e-10	61.2	COG4191@1|root,COG4191@2|Bacteria,1MVK7@1224|Proteobacteria,2TR44@28211|Alphaproteobacteria,4KM1M@93682|Roseivivax	28211|Alphaproteobacteria	T	His Kinase A (phosphoacceptor) domain	regM	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
k59_1655109_2	414684.RC1_2280	2.55e-13	69.3	COG0398@1|root,COG0398@2|Bacteria,1MVF3@1224|Proteobacteria,2U6DE@28211|Alphaproteobacteria,2JRU9@204441|Rhodospirillales	204441|Rhodospirillales	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
k59_433523_1	519989.ECTPHS_08823	1.39e-79	246.0	COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,1RNWJ@1236|Gammaproteobacteria,1WW4K@135613|Chromatiales	135613|Chromatiales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
k59_1047506_2	1280390.CBQR020000103_gene2772	7.54e-12	67.4	COG1475@1|root,COG1475@2|Bacteria,1TQ2B@1239|Firmicutes,4H9TB@91061|Bacilli,26RXG@186822|Paenibacillaceae	91061|Bacilli	K	Belongs to the ParB family	spo0J	GO:0005575,GO:0005622,GO:0005623,GO:0007059,GO:0008150,GO:0009295,GO:0009987,GO:0022603,GO:0042173,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0043937,GO:0043938,GO:0044424,GO:0044464,GO:0045595,GO:0045597,GO:0045881,GO:0048518,GO:0048522,GO:0050789,GO:0050793,GO:0050794,GO:0051094,GO:0065007	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	HTH_3,KorB,ParBc
k59_1101545_1	1255043.TVNIR_1329	9.89e-155	462.0	COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,1RMWN@1236|Gammaproteobacteria,1WW7D@135613|Chromatiales	135613|Chromatiales	C	Molybdopterin oxidoreductase Fe4S4 domain	napA	-	-	ko:K02567	ko00910,ko01120,map00910,map01120	M00529,M00530	R00798,R01106	RC02812	ko00000,ko00001,ko00002,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_1379811_2	344747.PM8797T_14716	2.76e-21	88.2	2DX6Z@1|root,343NZ@2|Bacteria	2|Bacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_3
k59_1325116_1	710687.KI912270_gene4329	6.6e-64	208.0	COG0309@1|root,COG0309@2|Bacteria,2GJ7N@201174|Actinobacteria,232GN@1762|Mycobacteriaceae	201174|Actinobacteria	O	hydrogenase expression formation protein HypE	hypE	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
k59_155382_1	1122939.ATUD01000001_gene310	1.13e-54	188.0	COG0138@1|root,COG0138@2|Bacteria,2GJWU@201174|Actinobacteria,4CPP3@84995|Rubrobacteria	84995|Rubrobacteria	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
k59_43667_1	85643.Tmz1t_0486	4.95e-24	105.0	COG5433@1|root,COG5433@2|Bacteria,1MXB5@1224|Proteobacteria,2VMZ8@28216|Betaproteobacteria,2KXIV@206389|Rhodocyclales	206389|Rhodocyclales	L	Transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
k59_1434473_1	42256.RradSPS_2936	5.11e-76	242.0	COG1156@1|root,COG1156@2|Bacteria,2I4C0@201174|Actinobacteria	201174|Actinobacteria	C	ATP synthase alpha/beta family, beta-barrel domain	-	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_433546_1	926550.CLDAP_27060	1.81e-90	295.0	COG0366@1|root,COG4733@1|root,COG0366@2|Bacteria,COG4733@2|Bacteria,2G7WY@200795|Chloroflexi	200795|Chloroflexi	G	Belongs to the glycosyl hydrolase 13 family	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,CBM_20,fn3
k59_1047528_1	671143.DAMO_0568	1.05e-38	144.0	COG0480@1|root,COG0480@2|Bacteria,2NNQD@2323|unclassified Bacteria	2|Bacteria	J	elongation factor G	fusA-1	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_1047528_2	1123371.ATXH01000025_gene206	3.89e-20	85.1	COG0779@1|root,COG0779@2|Bacteria,2GH5M@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Required for maturation of 30S ribosomal subunits	rimP	-	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
k59_155398_1	2002.JOEQ01000048_gene7447	8.92e-83	253.0	COG1117@1|root,COG1117@2|Bacteria,2GJQ3@201174|Actinobacteria,4EM3I@85012|Streptosporangiales	201174|Actinobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
k59_991352_1	1120950.KB892756_gene6692	4.98e-17	85.9	COG0301@1|root,COG0301@2|Bacteria,2GMFY@201174|Actinobacteria	201174|Actinobacteria	H	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	thiI	-	2.8.1.4	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07461	-	ko00000,ko00001,ko01000,ko03016	-	-	-	THUMP,ThiI
k59_544813_1	452637.Oter_3898	1.53e-07	58.9	COG1520@1|root,COG1520@2|Bacteria,46T0C@74201|Verrucomicrobia,3K9Y4@414999|Opitutae	414999|Opitutae	S	PFAM Pyrrolo-quinoline quinone	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_3
k59_544830_1	373994.Riv7116_2182	9.81e-29	120.0	COG1529@1|root,COG2080@1|root,COG1529@2|Bacteria,COG2080@2|Bacteria,1G35M@1117|Cyanobacteria,1HISS@1161|Nostocales	1117|Cyanobacteria	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	1.17.1.4	ko:K11177	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2
k59_155438_2	292415.Tbd_1072	1.96e-50	179.0	COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,2VS7B@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase_2
k59_822940_2	351607.Acel_0440	4.52e-12	67.0	COG2246@1|root,COG2246@2|Bacteria	2|Bacteria	S	polysaccharide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	GtrA
k59_43722_1	406552.NJ7G_2116	4.05e-125	368.0	COG1653@1|root,arCOG00151@2157|Archaea,2Y2AY@28890|Euryarchaeota,23Z4Y@183963|Halobacteria	183963|Halobacteria	G	COG1653 ABC-type sugar transport system, periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_209294_1	251229.Chro_1923	1.43e-34	132.0	COG2006@1|root,COG2006@2|Bacteria,1G1NA@1117|Cyanobacteria,3VIJ1@52604|Pleurocapsales	1117|Cyanobacteria	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
k59_654132_1	926550.CLDAP_25770	1.46e-13	66.2	COG2740@1|root,COG2740@2|Bacteria,2G72H@200795|Chloroflexi	200795|Chloroflexi	K	Protein of unknown function (DUF448)	-	-	-	ko:K07742	-	-	-	-	ko00000	-	-	-	DUF448
k59_43728_1	1282360.ABAC460_00655	7.22e-16	80.9	COG0823@1|root,COG0823@2|Bacteria,1R5P1@1224|Proteobacteria,2U0ZV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	U	Periplasmic component of the Tol biopolymer transport system	tolB2	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,PD40
k59_599566_1	1380394.JADL01000010_gene4243	1.03e-74	238.0	COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,2TRIJ@28211|Alphaproteobacteria,2JQBM@204441|Rhodospirillales	204441|Rhodospirillales	G	phosphomannomutase	exoC	-	5.4.2.8	ko:K01840	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01818	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_1157953_1	1380394.JADL01000002_gene1195	5.34e-60	210.0	COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,1MWDY@1224|Proteobacteria,2TTGI@28211|Alphaproteobacteria,2JQXB@204441|Rhodospirillales	204441|Rhodospirillales	I	Phosphate acyltransferases	-	-	2.3.1.40,6.2.1.20	ko:K05939	ko00071,ko00564,map00071,map00564	-	R01406,R04864	RC00014,RC00039,RC00041	ko00000,ko00001,ko01000	-	-	-	AMP-binding,Acyltransferase,MFS_1
k59_1047583_1	1288826.MSNKSG1_06113	4.77e-61	196.0	COG0500@1|root,COG2226@2|Bacteria,1RANW@1224|Proteobacteria,1S1F0@1236|Gammaproteobacteria,467F2@72275|Alteromonadaceae	1236|Gammaproteobacteria	Q	COG0500 SAM-dependent methyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23
k59_1655239_1	251221.35211453	2.18e-79	253.0	COG1174@1|root,COG1732@1|root,COG1174@2|Bacteria,COG1732@2|Bacteria,1G1ZS@1117|Cyanobacteria	1117|Cyanobacteria	M	Substrate binding domain of ABC-type glycine betaine transport system	-	-	-	ko:K05845,ko:K05846	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1,OpuAC
k59_324226_1	535289.Dtpsy_1684	5.62e-06	48.5	COG1309@1|root,COG1309@2|Bacteria,1MWF7@1224|Proteobacteria,2VMVD@28216|Betaproteobacteria,4ACY0@80864|Comamonadaceae	28216|Betaproteobacteria	K	regulatory protein TetR	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_4,TetR_N
k59_100352_1	290397.Adeh_2746	1.56e-63	210.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,42MUZ@68525|delta/epsilon subdivisions,2WJT6@28221|Deltaproteobacteria,2YXTZ@29|Myxococcales	28221|Deltaproteobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_1158008_1	479435.Kfla_2302	0.000183	48.5	COG0768@1|root,COG0768@2|Bacteria,2GJ61@201174|Actinobacteria,4DNKZ@85009|Propionibacteriales	201174|Actinobacteria	M	Penicillin-binding Protein dimerisation domain	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	FTSW_RODA_SPOVE,PBP_dimer,Transpeptidase
k59_100356_1	1280948.HY36_00935	3.09e-12	68.6	COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,2TSGT@28211|Alphaproteobacteria,43WIK@69657|Hyphomonadaceae	28211|Alphaproteobacteria	E	acetylornithine aminotransferase	argD	GO:0003674,GO:0005488,GO:0005515,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_100356_2	156889.Mmc1_3743	2.5e-61	199.0	COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,2TR81@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	-	2.1.3.3,2.1.3.6,2.1.3.9	ko:K00611,ko:K09065,ko:K13252	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01398,R07245	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_155523_1	1123500.ATUU01000002_gene797	1e-29	119.0	COG1732@1|root,COG1732@2|Bacteria,1TQ7D@1239|Firmicutes,4HBDR@91061|Bacilli,4AWKC@81850|Leuconostocaceae	91061|Bacilli	P	ABC-type proline glycine betaine transport systems, permease component	proWX	-	-	ko:K05845,ko:K05846	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1,OpuAC
k59_1491419_1	1454004.AW11_02357	1.89e-05	52.4	COG1807@1|root,COG1807@2|Bacteria,1NMIZ@1224|Proteobacteria,2VMHK@28216|Betaproteobacteria	28216|Betaproteobacteria	M	PFAM glycosyl transferase family 39	arnT	-	-	-	-	-	-	-	-	-	-	-	PMT_2
k59_713656_1	504472.Slin_6131	7.6e-08	58.9	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,4NHS5@976|Bacteroidetes,47MWY@768503|Cytophagia	976|Bacteroidetes	EU	Peptidase S9 prolyl oligopeptidase active site domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
k59_1766748_1	1196028.ALEF01000082_gene3447	3.27e-15	79.7	COG1196@1|root,COG1196@2|Bacteria,1UIE6@1239|Firmicutes,4IT31@91061|Bacilli	91061|Bacilli	D	Domain of unknown function (DUF4349)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4349
k59_491923_1	1449063.JMLS01000037_gene1747	7.94e-27	112.0	COG4733@1|root,COG4733@2|Bacteria,1UIP7@1239|Firmicutes,4IV3N@91061|Bacilli,277T9@186822|Paenibacillaceae	91061|Bacilli	S	Protein of unknown function (DUF2961)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2961
k59_654221_1	1206731.BAGB01000166_gene851	2.79e-27	112.0	COG1960@1|root,COG1960@2|Bacteria,2GKVN@201174|Actinobacteria,4FYUQ@85025|Nocardiaceae	201174|Actinobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_N
k59_378529_1	305700.B447_16824	1.17e-49	177.0	COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,2VHE8@28216|Betaproteobacteria,2KUCJ@206389|Rhodocyclales	206389|Rhodocyclales	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
k59_991485_1	1395571.TMS3_0102290	1.74e-26	109.0	COG2823@1|root,COG2823@2|Bacteria,1RHX0@1224|Proteobacteria,1S742@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	bacterial OsmY and nodulation domain	-	-	-	-	-	-	-	-	-	-	-	-	BON
k59_280556_2	468556.AQYG01000041_gene3538	1.56e-57	190.0	COG0183@1|root,COG0183@2|Bacteria,2GIY0@201174|Actinobacteria,4GB15@85026|Gordoniaceae	201174|Actinobacteria	I	Thiolase, C-terminal domain	-	-	2.3.1.16	ko:K00632	ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212	M00087,M00113	R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000	-	-	-	Thiolase_C,Thiolase_N
k59_558411_1	468059.AUHA01000003_gene1803	1.47e-13	75.1	COG1560@1|root,COG1560@2|Bacteria,4NGQU@976|Bacteroidetes,1IRHE@117747|Sphingobacteriia	976|Bacteroidetes	M	PFAM Bacterial lipid A biosynthesis acyltransferase	waaM	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
k59_669788_1	1469245.JFBG01000037_gene1851	1.55e-68	211.0	COG2030@1|root,COG2030@2|Bacteria,1MW4N@1224|Proteobacteria,1S43F@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	dehydratase	-	-	4.2.1.56	ko:K18290	ko00660,map00660	-	R02491	RC00730	ko00000,ko00001,ko01000	-	-	-	MaoC_dehydratas
k59_502968_1	45596.XP_006684564.1	9.78e-06	49.7	COG0694@1|root,KOG2358@2759|Eukaryota,38H60@33154|Opisthokonta,3NYHI@4751|Fungi,3QKKV@4890|Ascomycota,3RT2C@4891|Saccharomycetes,47B4P@766764|Debaryomycetaceae	4751|Fungi	O	Scaffold protein Nfu/NifU N terminal	NFU1	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006790,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0006880,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016226,GO:0019538,GO:0019725,GO:0022607,GO:0030003,GO:0031163,GO:0031974,GO:0042592,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044085,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046916,GO:0048878,GO:0050801,GO:0051179,GO:0051186,GO:0051235,GO:0051238,GO:0051604,GO:0051641,GO:0051651,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0070013,GO:0071704,GO:0071840,GO:0097428,GO:0097577,GO:0098771,GO:1901564	-	ko:K22074	-	-	-	-	ko00000,ko03029	-	-	-	Nfu_N,NifU
k59_502968_2	1349767.GJA_1732	8.58e-10	61.2	COG0160@1|root,COG0160@2|Bacteria,1MWY6@1224|Proteobacteria,2VZ8W@28216|Betaproteobacteria,4773V@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	Aminotransferase class-III	-	-	2.6.1.19,2.6.1.76	ko:K00823,ko:K00836	ko00250,ko00260,ko00410,ko00640,ko00650,ko01100,ko01120,ko01210,ko01230,map00250,map00260,map00410,map00640,map00650,map01100,map01120,map01210,map01230	M00027,M00033	R00908,R01648,R06977	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_1392292_1	105559.Nwat_2850	4.44e-25	102.0	COG1596@1|root,COG1596@2|Bacteria,1N7GP@1224|Proteobacteria,1RQSM@1236|Gammaproteobacteria,1WYMP@135613|Chromatiales	135613|Chromatiales	M	polysaccharide export protein	-	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
k59_836456_1	1278307.KB907057_gene2644	1.83e-62	202.0	COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,1RMF9@1236|Gammaproteobacteria,2QJ5B@267894|Psychromonadaceae	1236|Gammaproteobacteria	L	COG3547 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_502980_1	530564.Psta_1780	8.78e-87	267.0	COG3386@1|root,COG3386@2|Bacteria,2IXZT@203682|Planctomycetes	203682|Planctomycetes	G	gluconolactonase	-	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	SGL
k59_2714_2	289376.THEYE_A0594	4.77e-118	350.0	COG0156@1|root,COG0156@2|Bacteria,3J0XU@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	-	-	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_1725987_1	1121943.KB899993_gene235	3.2e-51	178.0	COG0637@1|root,COG1877@1|root,COG0637@2|Bacteria,COG1877@2|Bacteria,1RGY2@1224|Proteobacteria,1RNIQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Removes the phosphate from trehalose 6-phosphate to produce free trehalose	otsB	GO:0000287,GO:0003674,GO:0003824,GO:0004805,GO:0005488,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0009058,GO:0009266,GO:0009311,GO:0009312,GO:0009409,GO:0009628,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0033554,GO:0034637,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0046351,GO:0046872,GO:0050896,GO:0051716,GO:0070413,GO:0070415,GO:0070417,GO:0071704,GO:1901576	3.1.3.12	ko:K01087	ko00500,ko01100,map00500,map01100	-	R02778	RC00017	ko00000,ko00001,ko01000	-	-	iE2348C_1286.E2348C_2018,iECED1_1282.ECED1_2163,iECIAI39_1322.ECIAI39_1155,iECS88_1305.ECS88_1952,iLF82_1304.LF82_1582,iNRG857_1313.NRG857_09495	Trehalose_PPase
k59_2719_1	1501230.ET33_13240	4.8e-43	152.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	2.7.1.83	ko:K16328	ko00240,map00240	-	R03315	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25
k59_224959_1	406124.ACPC01000020_gene3931	1.57e-12	73.9	COG3266@1|root,COG3266@2|Bacteria,1VDA3@1239|Firmicutes,4ITGR@91061|Bacilli,1ZDHT@1386|Bacillus	91061|Bacilli	S	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Flg_new,TPR_19
k59_58249_1	164328.Phyra72693	9.82e-07	55.5	KOG4351@1|root,KOG4351@2759|Eukaryota,3Q8PI@4776|Peronosporales	4776|Peronosporales	S	Ig-like domain from next to BRCA1 gene	-	-	-	ko:K17987	ko04137,map04137	-	-	-	ko00000,ko00001,ko03029,ko04131	-	-	-	N_BRCA1_IG,PB1
k59_1448200_1	1504672.669785679	5.92e-26	106.0	COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,2VKD6@28216|Betaproteobacteria,4AF3N@80864|Comamonadaceae	28216|Betaproteobacteria	L	PFAM transposase, mutator type	-	-	-	ko:K07493	-	-	-	-	ko00000	-	-	-	Transposase_mut
k59_1228227_1	1424334.W822_16445	1.42e-58	194.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VJDW@28216|Betaproteobacteria,3T2J8@506|Alcaligenaceae	28216|Betaproteobacteria	C	carnitine dehydratase	-	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
k59_1672551_1	1379270.AUXF01000003_gene3644	7.74e-44	154.0	COG2885@1|root,COG2885@2|Bacteria,1ZTR2@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
k59_1060885_2	990285.RGCCGE502_15055	4.67e-56	182.0	COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,2TTKG@28211|Alphaproteobacteria,4B7U3@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	response regulator	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_1172123_1	216594.MMAR_4821	1.63e-15	81.6	COG2159@1|root,COG2159@2|Bacteria,2HG7W@201174|Actinobacteria,237SC@1762|Mycobacteriaceae	201174|Actinobacteria	S	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
k59_1728063_2	926550.CLDAP_09810	1.07e-56	190.0	COG0601@1|root,COG0601@2|Bacteria,2G6BV@200795|Chloroflexi	200795|Chloroflexi	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_671958_1	649747.HMPREF0083_00032	8.69e-45	166.0	COG0013@1|root,COG0013@2|Bacteria,1TPK6@1239|Firmicutes,4H9XC@91061|Bacilli,26RFD@186822|Paenibacillaceae	91061|Bacilli	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
k59_1505637_1	1122939.ATUD01000003_gene3613	7.55e-47	164.0	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,4CPCN@84995|Rubrobacteria	84995|Rubrobacteria	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_1172134_1	471852.Tcur_3805	1.34e-24	110.0	COG2972@1|root,COG2972@2|Bacteria,2I6J7@201174|Actinobacteria,4ER7Y@85012|Streptosporangiales	201174|Actinobacteria	T	Nitrate and nitrite sensing	-	-	-	-	-	-	-	-	-	-	-	-	NIT
k59_171513_1	999541.bgla_2g11140	5.21e-50	178.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VHB0@28216|Betaproteobacteria,1K17R@119060|Burkholderiaceae	28216|Betaproteobacteria	C	PFAM L-carnitine dehydratase bile acid-inducible protein F	-	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
k59_560472_2	1121468.AUBR01000045_gene1804	6.31e-07	49.3	COG3809@1|root,COG3809@2|Bacteria,1VIH3@1239|Firmicutes,24STF@186801|Clostridia,42IQE@68295|Thermoanaerobacterales	186801|Clostridia	S	Transcription factor zinc-finger	-	-	-	ko:K09981	-	-	-	-	ko00000	-	-	-	zf-TFIIB
k59_616201_1	1196324.A374_13760	2.91e-39	142.0	COG1131@1|root,COG1131@2|Bacteria,1TPMQ@1239|Firmicutes,4HA8K@91061|Bacilli	91061|Bacilli	V	abc transporter atp-binding protein	-	-	-	ko:K01990,ko:K11050	ko02010,map02010	M00254,M00298	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.130	-	-	ABC_tran
k59_838527_1	1128421.JAGA01000001_gene2136	4.85e-54	182.0	COG0683@1|root,COG0683@2|Bacteria	2|Bacteria	E	ABC-type branched-chain amino acid transport systems, periplasmic component	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_672017_1	98439.AJLL01000098_gene1920	2.5e-41	144.0	COG4627@1|root,COG4627@2|Bacteria,1GKUS@1117|Cyanobacteria,1JMS3@1189|Stigonemataceae	1117|Cyanobacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_505213_1	357808.RoseRS_3450	1.47e-05	48.5	COG1122@1|root,COG1122@2|Bacteria,2G5RY@200795|Chloroflexi,376ER@32061|Chloroflexia	32061|Chloroflexia	P	PFAM ABC transporter related	-	-	-	ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
k59_282868_1	767029.HMPREF9154_1966	2.23e-05	52.4	COG0028@1|root,COG0028@2|Bacteria,2GKU4@201174|Actinobacteria	201174|Actinobacteria	E	Acetolactate synthase	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_449668_1	679897.HMU01550	2.41e-06	55.1	COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,42M1C@68525|delta/epsilon subdivisions,2YMF3@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	E	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
k59_838539_1	595537.Varpa_2539	2.07e-64	219.0	COG2885@1|root,COG3808@1|root,COG2885@2|Bacteria,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,2VI3K@28216|Betaproteobacteria,4AA75@80864|Comamonadaceae	28216|Betaproteobacteria	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase,OmpA
k59_505226_1	1429046.RR21198_1601	8.35e-78	250.0	COG0332@1|root,COG0332@2|Bacteria,2IAG3@201174|Actinobacteria,4G038@85025|Nocardiaceae	201174|Actinobacteria	I	3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal	-	-	-	-	-	-	-	-	-	-	-	-	ACP_syn_III,ACP_syn_III_C
k59_1339044_1	1385935.N836_17710	1.14e-34	134.0	COG0659@1|root,COG0659@2|Bacteria,1G1F1@1117|Cyanobacteria,1H92U@1150|Oscillatoriales	1117|Cyanobacteria	P	Sulfate transporter	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
k59_505236_1	379066.GAU_1588	1.32e-57	192.0	COG0764@1|root,COG0774@1|root,COG0764@2|Bacteria,COG0774@2|Bacteria,1ZT4Z@142182|Gemmatimonadetes	142182|Gemmatimonadetes	IM	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis	fabZ	-	3.5.1.108,4.2.1.59	ko:K16363	ko00061,ko00540,ko01100,ko01212,map00061,map00540,map01100,map01212	M00060,M00083	R04428,R04535,R04537,R04544,R04568,R04587,R04954,R04965	RC00166,RC00300,RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004,ko01005	-	-	-	FabA,LpxC
k59_505236_2	880072.Desac_2715	1.29e-13	72.8	COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,42NPG@68525|delta/epsilon subdivisions,2WJVP@28221|Deltaproteobacteria,2MREM@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxA	-	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Acetyltransf_11,Hexapep
k59_727699_1	644107.SL1157_1377	3.71e-30	110.0	COG3795@1|root,COG3795@2|Bacteria,1RJJG@1224|Proteobacteria,2UCR2@28211|Alphaproteobacteria,4NCMU@97050|Ruegeria	28211|Alphaproteobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
k59_1505722_1	1173028.ANKO01000017_gene220	7.2e-69	229.0	COG0205@1|root,COG0205@2|Bacteria,1G0N7@1117|Cyanobacteria,1H82M@1150|Oscillatoriales	1117|Cyanobacteria	G	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	-	-	2.7.1.11	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
k59_838566_1	868131.MSWAN_2371	8.35e-10	63.2	COG0500@1|root,arCOG02702@2157|Archaea,2XZV2@28890|Euryarchaeota,23PHW@183925|Methanobacteria	183925|Methanobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
k59_1228357_1	1424334.W822_00505	5.62e-06	48.5	COG3826@1|root,COG3826@2|Bacteria,1MWVV@1224|Proteobacteria,2VHMX@28216|Betaproteobacteria,3T2DN@506|Alcaligenaceae	28216|Betaproteobacteria	S	Oxygenase, catalysing oxidative methylation of damaged DNA	-	-	-	ko:K09990	-	-	-	-	ko00000	-	-	-	Oxygenase-NA
k59_338161_1	1429916.X566_16440	2.37e-77	239.0	COG1024@1|root,COG1024@2|Bacteria,1PSRK@1224|Proteobacteria,2U22I@28211|Alphaproteobacteria,3JVPX@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
k59_894510_1	1121448.DGI_0743	1.94e-62	203.0	COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,42KZG@68525|delta/epsilon subdivisions,2WIQ5@28221|Deltaproteobacteria,2M84M@213115|Desulfovibrionales	28221|Deltaproteobacteria	F	Belongs to the CarA family	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
k59_115925_1	1492922.GY26_14660	3.86e-17	81.6	COG0405@1|root,COG0405@2|Bacteria,1MXXD@1224|Proteobacteria	1224|Proteobacteria	E	gamma-glutamyltransferase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k59_616270_1	639030.JHVA01000001_gene1853	1.22e-45	157.0	COG4447@1|root,COG4447@2|Bacteria,3Y3TM@57723|Acidobacteria,2JHSZ@204432|Acidobacteriia	204432|Acidobacteriia	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR
k59_616270_2	492774.JQMB01000014_gene1510	3.55e-36	125.0	COG0346@1|root,COG0346@2|Bacteria,1NZNJ@1224|Proteobacteria,2UTNS@28211|Alphaproteobacteria,4BEWN@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
k59_1339101_1	1381123.AYOD01000054_gene434	4.48e-61	204.0	COG0076@1|root,COG0076@2|Bacteria,1MWUX@1224|Proteobacteria,2TTUK@28211|Alphaproteobacteria,43IWV@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	PFAM Pyridoxal-dependent decarboxylase	-	-	-	-	-	-	-	-	-	-	-	-	Pyridoxal_deC
k59_449735_1	234267.Acid_3938	2.37e-09	60.8	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
k59_1228391_1	742727.HMPREF9447_05032	4.92e-17	85.5	COG3637@1|root,COG3637@2|Bacteria,4NIPZ@976|Bacteroidetes,2FQ2F@200643|Bacteroidia,4ANBF@815|Bacteroidaceae	976|Bacteroidetes	M	COG NOG32048 non supervised orthologous group	-	-	-	ko:K21572	-	-	-	-	ko00000,ko02000	8.A.46.1,8.A.46.3	-	-	SusD-like_3,SusD_RagB
k59_282944_1	234267.Acid_3938	7.61e-25	111.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
k59_894536_2	861299.J421_3630	7.51e-32	126.0	COG0243@1|root,COG0437@1|root,COG0243@2|Bacteria,COG0437@2|Bacteria,1ZSRY@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	4Fe-4S dicluster domain	-	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal
k59_783154_1	1267534.KB906754_gene2784	2.48e-29	122.0	COG0577@1|root,COG0577@2|Bacteria,3Y3KJ@57723|Acidobacteria,2JI3C@204432|Acidobacteriia	204432|Acidobacteriia	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_894547_1	118161.KB235922_gene2198	8.5e-12	64.7	COG3677@1|root,COG3677@2|Bacteria,1GA9U@1117|Cyanobacteria,3VN7A@52604|Pleurocapsales	1117|Cyanobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_1672712_1	1267535.KB906767_gene316	6.05e-86	273.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,3Y3NT@57723|Acidobacteria,2JIBK@204432|Acidobacteriia	204432|Acidobacteriia	EU	Dipeptidyl peptidase IV (DPP IV) N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	DPPIV_N,PD40,Peptidase_S9
k59_783178_1	1197906.CAJQ02000043_gene1927	9.74e-17	82.4	COG1868@1|root,COG1868@2|Bacteria,1MX01@1224|Proteobacteria,2TR4F@28211|Alphaproteobacteria,3JRPA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	N	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation	fliM	-	-	ko:K02416	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliM,FliMN_C
k59_783178_2	1380394.JADL01000014_gene255	2.31e-33	120.0	COG1580@1|root,COG1580@2|Bacteria,1RH5D@1224|Proteobacteria,2U9BF@28211|Alphaproteobacteria,2JST8@204441|Rhodospirillales	204441|Rhodospirillales	N	Controls the rotational direction of flagella during chemotaxis	fliL	-	-	ko:K02415	-	-	-	-	ko00000,ko02035	-	-	-	FliL
k59_115980_1	637389.Acaty_c2281	7.66e-99	308.0	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,1SYC8@1236|Gammaproteobacteria,2NE68@225057|Acidithiobacillales	225057|Acidithiobacillales	P	STAS domain	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
k59_1172297_1	298386.PBPRA2030	1.55e-103	323.0	COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,1RMWN@1236|Gammaproteobacteria,1XZWM@135623|Vibrionales	135623|Vibrionales	C	Molydopterin dinucleotide binding domain	-	-	-	ko:K02567	ko00910,ko01120,map00910,map01120	M00529,M00530	R00798,R01106	RC02812	ko00000,ko00001,ko00002,ko01000	-	-	-	Molybdopterin,Molydop_binding
k59_1450538_1	1033743.CAES01000080_gene3892	5.31e-35	134.0	COG0611@1|root,COG0611@2|Bacteria,1V0SM@1239|Firmicutes,4HG10@91061|Bacilli,26STN@186822|Paenibacillaceae	91061|Bacilli	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU05900	AIRS,AIRS_C
k59_171656_1	1123368.AUIS01000004_gene161	5.05e-05	45.4	COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,1RN3R@1236|Gammaproteobacteria,2NCBN@225057|Acidithiobacillales	225057|Acidithiobacillales	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	-	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
k59_1672740_2	1123023.JIAI01000001_gene7522	4.58e-69	220.0	COG0006@1|root,COG0006@2|Bacteria,2H45Q@201174|Actinobacteria,4ED6U@85010|Pseudonocardiales	201174|Actinobacteria	E	Creatinase/Prolidase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
k59_727801_1	1142394.PSMK_16050	9.63e-32	128.0	COG1363@1|root,COG1363@2|Bacteria	2|Bacteria	G	aminopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28,Peptidase_M42
k59_616346_1	760568.Desku_1748	1.31e-66	214.0	COG0451@1|root,COG0451@2|Bacteria,1VP6I@1239|Firmicutes,251A8@186801|Clostridia,264EF@186807|Peptococcaceae	186801|Clostridia	M	PFAM NAD dependent epimerase dehydratase family	capI	-	5.1.3.6	ko:K08679	ko00520,ko01100,map00520,map01100	-	R01385	RC00289	ko00000,ko00001,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
k59_1450546_1	710686.Mycsm_01832	3.59e-21	95.9	COG2358@1|root,COG2358@2|Bacteria,2I9QR@201174|Actinobacteria	201174|Actinobacteria	S	NMT1-like family	-	-	-	-	-	-	-	-	-	-	-	-	NMT1_3
k59_950068_1	1469245.JFBG01000027_gene1470	2.59e-79	251.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria	1224|Proteobacteria	E	ABC-Type Dipeptide Transport System Periplasmic Component	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_1172320_1	1254432.SCE1572_14990	8.08e-05	45.8	COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,42N97@68525|delta/epsilon subdivisions,2WKVE@28221|Deltaproteobacteria,2YV07@29|Myxococcales	28221|Deltaproteobacteria	S	Transporter associated domain	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
k59_1172320_2	309801.trd_0031	8.2e-32	124.0	COG1207@1|root,COG1207@2|Bacteria,2G5VC@200795|Chloroflexi,27Y0S@189775|Thermomicrobia	189775|Thermomicrobia	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transf_3
k59_1117035_1	1449063.JMLS01000013_gene6062	1.52e-17	87.8	COG0642@1|root,COG0745@1|root,COG3850@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,COG3850@2|Bacteria,1UEIC@1239|Firmicutes,4HDD8@91061|Bacilli,26RKT@186822|Paenibacillaceae	91061|Bacilli	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	4HB_MCP_1,GAF_2,HATPase_c,HisKA,Response_reg
k59_965781_2	991905.SL003B_1083	8.93e-32	122.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,2TRFK@28211|Alphaproteobacteria,4BRTY@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Transketolase, pyrimidine binding domain	-	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
k59_853445_1	1122919.KB905555_gene892	5.71e-09	63.2	COG3973@1|root,COG3973@2|Bacteria,1TP39@1239|Firmicutes,4H9Y5@91061|Bacilli,26SYX@186822|Paenibacillaceae	91061|Bacilli	L	DNA helicase	uvrD	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_19,UvrD-helicase,UvrD_C,UvrD_C_2
k59_1521360_1	1459636.NTE_01742	8.7e-62	199.0	COG2513@1|root,arCOG00581@2157|Archaea,41SEN@651137|Thaumarchaeota	651137|Thaumarchaeota	G	Phosphoenolpyruvate phosphomutase	-	-	-	-	-	-	-	-	-	-	-	-	PEP_mutase
k59_520990_1	864069.MicloDRAFT_00004650	1.04e-66	214.0	COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,2TRGY@28211|Alphaproteobacteria,1JZ15@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	PFAM IstB-like ATP binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
k59_799028_1	350054.Mflv_3121	2.7e-12	72.4	COG2267@1|root,COG3710@1|root,COG2267@2|Bacteria,COG3710@2|Bacteria,2I419@201174|Actinobacteria,234R8@1762|Mycobacteriaceae	201174|Actinobacteria	IK	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Trans_reg_C
k59_1187946_1	1268622.AVS7_03895	3.29e-52	187.0	COG3614@1|root,COG5001@1|root,COG3614@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,4A9PA@80864|Comamonadaceae	28216|Betaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,EAL,GAF_2,GGDEF,PAS,PAS_3,PAS_4,PAS_7,PAS_8,PAS_9
k59_1412560_1	1123253.AUBD01000005_gene136	4.91e-50	174.0	COG1972@1|root,COG1972@2|Bacteria,1MXXX@1224|Proteobacteria,1RMBX@1236|Gammaproteobacteria,1X3AE@135614|Xanthomonadales	135614|Xanthomonadales	F	Na dependent nucleoside transporter	yeiM	-	-	ko:K03317	-	-	-	-	ko00000	2.A.41	-	-	Gate,Nucleos_tra2_C,Nucleos_tra2_N
k59_913268_1	1279009.ADICEAN_03372	2.44e-34	135.0	COG2091@1|root,COG2091@2|Bacteria,4NFQ6@976|Bacteroidetes,47NT4@768503|Cytophagia	976|Bacteroidetes	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
k59_745557_1	926569.ANT_02400	8.05e-81	252.0	COG0381@1|root,COG0381@2|Bacteria,2G7S6@200795|Chloroflexi	200795|Chloroflexi	M	Belongs to the UDP-N-acetylglucosamine 2-epimerase family	-	-	5.1.3.14	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase_2
k59_78047_1	290397.Adeh_0547	9.84e-70	217.0	COG3576@1|root,COG3576@2|Bacteria,1NBWC@1224|Proteobacteria,42X9X@68525|delta/epsilon subdivisions,2X3AH@28221|Deltaproteobacteria,2YV4Q@29|Myxococcales	28221|Deltaproteobacteria	S	Pfam:Pyridox_oxidase	-	-	-	ko:K07006	-	-	-	-	ko00000	-	-	-	Putative_PNPOx
k59_1357166_1	926550.CLDAP_39020	3.07e-52	178.0	COG1804@1|root,COG1804@2|Bacteria,2G7MX@200795|Chloroflexi	200795|Chloroflexi	C	PFAM L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_1247559_2	132113.XP_003485224.1	1.89e-09	62.4	COG0388@1|root,KOG4315@1|root,KOG0806@2759|Eukaryota,KOG4315@2759|Eukaryota,38TQE@33154|Opisthokonta,3B9AV@33208|Metazoa,3CSJF@33213|Bilateria,41TCG@6656|Arthropoda,3SFRS@50557|Insecta,46HRD@7399|Hymenoptera	33208|Metazoa	E	Carbon-nitrogen hydrolase	NIT2	GO:0001775,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0003674,GO:0003824,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005813,GO:0005815,GO:0005829,GO:0005856,GO:0006082,GO:0006107,GO:0006520,GO:0006528,GO:0006541,GO:0006807,GO:0006810,GO:0006887,GO:0006955,GO:0008150,GO:0008152,GO:0009064,GO:0009066,GO:0009987,GO:0012505,GO:0015630,GO:0016192,GO:0016787,GO:0016810,GO:0016811,GO:0019752,GO:0030141,GO:0031410,GO:0031974,GO:0031982,GO:0031983,GO:0032787,GO:0032940,GO:0034641,GO:0034774,GO:0035580,GO:0036230,GO:0042119,GO:0042581,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043232,GO:0043233,GO:0043299,GO:0043312,GO:0043436,GO:0043603,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044430,GO:0044433,GO:0044444,GO:0044446,GO:0044464,GO:0045055,GO:0045321,GO:0046903,GO:0050152,GO:0050896,GO:0051179,GO:0051234,GO:0060205,GO:0070013,GO:0070820,GO:0071704,GO:0097708,GO:0099503,GO:1901564,GO:1901605,GO:1904724	3.5.1.3	ko:K13101,ko:K13566	ko00250,map00250	-	R00269,R00348	RC00010	ko00000,ko00001,ko01000,ko03041	-	-	-	CN_hydrolase
k59_690357_1	1521187.JPIM01000013_gene2749	5.62e-105	318.0	COG1027@1|root,COG1027@2|Bacteria,2G5IV@200795|Chloroflexi,37644@32061|Chloroflexia	32061|Chloroflexia	C	PFAM fumarate lyase	-	-	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
k59_968087_1	1047013.AQSP01000103_gene1160	2.22e-75	247.0	COG1770@1|root,COG1770@2|Bacteria,2NNMF@2323|unclassified Bacteria	2|Bacteria	E	Prolyl oligopeptidase, N-terminal beta-propeller domain	ptrB	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0070011,GO:0070012,GO:0071704,GO:0140096,GO:1901564	3.4.21.83	ko:K01354	ko05142,ko05143,map05142,map05143	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
k59_968090_1	1379270.AUXF01000002_gene1585	3.13e-61	213.0	COG0515@1|root,COG0515@2|Bacteria,1ZUMJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
k59_189169_1	883067.HMPREF9237_00047	1.64e-25	113.0	COG1615@1|root,COG1615@2|Bacteria,2GMP3@201174|Actinobacteria,4D3E2@85005|Actinomycetales	201174|Actinobacteria	S	UPF0182 protein	-	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
k59_855544_1	1392487.JIAD01000001_gene492	1.16e-46	172.0	COG0493@1|root,COG3383@1|root,COG0493@2|Bacteria,COG3383@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,25UR0@186806|Eubacteriaceae	186801|Clostridia	C	NADPH-dependent glutamate synthase beta chain and related oxidoreductases	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_20,Fer4_6,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Pyr_redox_2,Pyr_redox_3
k59_1078814_1	926569.ANT_22610	4.26e-31	118.0	COG2348@1|root,COG2348@2|Bacteria,2G6KK@200795|Chloroflexi	200795|Chloroflexi	V	PFAM Methicillin resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	FemAB
k59_690376_1	1279009.ADICEAN_02455	1.5e-07	57.4	COG0793@1|root,COG0793@2|Bacteria,4NEF4@976|Bacteroidetes,47K87@768503|Cytophagia	976|Bacteroidetes	M	PDZ DHR GLGF domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2,PDZ,PDZ_2
k59_1633904_1	1121104.AQXH01000003_gene337	2.68e-54	184.0	COG2270@1|root,COG2270@2|Bacteria,4NEKI@976|Bacteroidetes,1INX9@117747|Sphingobacteriia	976|Bacteroidetes	S	COGs COG2270 Permease of the major facilitator superfamily	-	-	-	ko:K06902	ko04138,map04138	-	-	-	ko00000,ko00001,ko02000,ko04131	2.A.1.24,9.A.15.1	-	-	ATG22
k59_523153_1	358681.BBR47_15350	9.2e-36	135.0	COG0477@1|root,COG2814@2|Bacteria,1TS6K@1239|Firmicutes,4HB1V@91061|Bacilli,26RFG@186822|Paenibacillaceae	91061|Bacilli	EGP	Permeases of the major facilitator superfamily	blt	-	-	ko:K08153	-	M00717	-	-	ko00000,ko00002,ko02000	2.A.1.2.8	-	-	MFS_1,MFS_1_like,Sugar_tr
k59_801263_2	316057.RPD_0881	3.83e-61	201.0	COG3396@1|root,COG3396@2|Bacteria,1MXUK@1224|Proteobacteria,2TTIG@28211|Alphaproteobacteria,3JSI1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	benzoyl-CoA oxygenase	boxB	-	1.14.13.208	ko:K15512	ko00362,map00362	-	R09555	RC01739	ko00000,ko00001,ko01000	-	-	-	-
k59_1523753_1	234267.Acid_5808	1.97e-100	301.0	COG0176@1|root,COG0176@2|Bacteria,3Y6V9@57723|Acidobacteria	57723|Acidobacteria	H	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	-	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
k59_468346_1	1403948.Q618_VCMC00001G0432	3.96e-71	233.0	COG0481@1|root,COG0481@2|Bacteria,2GJAB@201174|Actinobacteria,4D42B@85005|Actinomycetales	201174|Actinobacteria	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
k59_913345_1	1894.JOER01000002_gene3606	5.28e-52	179.0	COG0520@1|root,COG0520@2|Bacteria,2H9MG@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. EgtE subfamily	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
k59_690397_1	266779.Meso_1396	4.23e-119	368.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2TQK9@28211|Alphaproteobacteria,43J2Q@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_78122_1	1487923.DP73_11180	3.62e-72	232.0	COG0370@1|root,COG0370@2|Bacteria,1TP7E@1239|Firmicutes,24885@186801|Clostridia,2612J@186807|Peptococcaceae	186801|Clostridia	P	transporter of a GTP-driven Fe(2 ) uptake system	-	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
k59_78130_1	457421.CBFG_00418	4.67e-15	76.6	COG0287@1|root,COG0287@2|Bacteria,1TPXG@1239|Firmicutes,248KX@186801|Clostridia	186801|Clostridia	E	prephenate dehydrogenase	tyrA	-	1.3.1.12	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PDH
k59_78130_2	866895.HBHAL_3274	4.67e-19	87.0	COG0128@1|root,COG0128@2|Bacteria,1TPIH@1239|Firmicutes,4HBHZ@91061|Bacilli,3ND7Q@45667|Halobacillus	91061|Bacilli	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
k59_189224_1	1140.Synpcc7942_0651	0.000342	45.1	COG1198@1|root,COG1198@2|Bacteria,1G2IZ@1117|Cyanobacteria,1GZ4R@1129|Synechococcus	1117|Cyanobacteria	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C
k59_189224_2	414684.RC1_2244	5.86e-05	45.1	COG0712@1|root,COG0712@2|Bacteria,1MVRH@1224|Proteobacteria,2U5IC@28211|Alphaproteobacteria,2JS4B@204441|Rhodospirillales	204441|Rhodospirillales	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
k59_1468443_1	675816.VIA_002701	4.62e-12	65.5	2ER5N@1|root,33IR8@2|Bacteria,1NNIR@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1468443_2	1121422.AUMW01000020_gene1702	4.69e-07	52.4	COG2217@1|root,COG2217@2|Bacteria,1TP5S@1239|Firmicutes,247MW@186801|Clostridia,2608V@186807|Peptococcaceae	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	copA	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
k59_1357271_1	1121930.AQXG01000004_gene2806	1.08e-11	70.9	COG1503@1|root,COG1503@2|Bacteria,4NHJS@976|Bacteroidetes,1J13F@117747|Sphingobacteriia	976|Bacteroidetes	J	translation release factor activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_523216_1	285535.JOEY01000003_gene10401	2e-44	155.0	COG2141@1|root,COG2141@2|Bacteria,2H0K9@201174|Actinobacteria	201174|Actinobacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_133423_1	485913.Krac_10412	4.58e-14	74.7	COG1670@1|root,COG1670@2|Bacteria,2G73Y@200795|Chloroflexi	200795|Chloroflexi	J	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
k59_801324_1	269799.Gmet_0613	1.41e-11	60.5	COG0690@1|root,COG0690@2|Bacteria,1Q1BI@1224|Proteobacteria,42X4Z@68525|delta/epsilon subdivisions,2WSQ8@28221|Deltaproteobacteria,43VQU@69541|Desulfuromonadales	28221|Deltaproteobacteria	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	-	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
k59_801324_2	56780.SYN_00070	2.15e-71	220.0	COG0250@1|root,COG0250@2|Bacteria,1MU14@1224|Proteobacteria,42MPQ@68525|delta/epsilon subdivisions,2WMP6@28221|Deltaproteobacteria,2MQF6@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	Participates in transcription elongation, termination and antitermination	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
k59_801324_3	243231.GSU2867	1.79e-11	60.8	COG0080@1|root,COG0080@2|Bacteria,1RA2M@1224|Proteobacteria,42RE7@68525|delta/epsilon subdivisions,2WNAH@28221|Deltaproteobacteria,43UTJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
k59_1412699_2	565045.NOR51B_2190	7.07e-10	58.9	COG0582@1|root,COG0582@2|Bacteria,1P1R9@1224|Proteobacteria,1RRV0@1236|Gammaproteobacteria,1J9F0@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	Phage integrase	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
k59_1190353_2	214092.YPO1716	3.96e-58	194.0	COG1823@1|root,COG1823@2|Bacteria,1R3F8@1224|Proteobacteria,1RMHV@1236|Gammaproteobacteria,41EEV@629|Yersinia	1236|Gammaproteobacteria	U	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family	ydjN	GO:0000099,GO:0000101,GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006791,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015179,GO:0015184,GO:0015318,GO:0015711,GO:0015804,GO:0015807,GO:0015811,GO:0015849,GO:0016020,GO:0022857,GO:0034220,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072337,GO:0072348,GO:0072349,GO:0098656,GO:1901682,GO:1902475,GO:1903825,GO:1905039	-	ko:K06956	-	-	-	-	ko00000	-	-	-	SDF
k59_189287_1	1173264.KI913949_gene2152	5.8e-41	153.0	COG0577@1|root,COG0577@2|Bacteria,1G0Z7@1117|Cyanobacteria,1H9BF@1150|Oscillatoriales	1117|Cyanobacteria	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_355765_1	468059.AUHA01000002_gene563	3.11e-63	219.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,4NFW7@976|Bacteroidetes,1IR3J@117747|Sphingobacteriia	976|Bacteroidetes	K	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	ANAPC3,Guanylate_cyc,HTH_18,TPR_8
k59_1135246_1	404589.Anae109_4187	9.65e-86	277.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,42M9S@68525|delta/epsilon subdivisions,2WJSZ@28221|Deltaproteobacteria,2YUBF@29|Myxococcales	28221|Deltaproteobacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695,ko:K03696	ko01100,ko04213,map01100,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_1247686_1	1219585.HMPREF1631_04190	2.03e-09	57.8	COG1053@1|root,COG1053@2|Bacteria,2GJ45@201174|Actinobacteria,4D3ZZ@85005|Actinomycetales	201174|Actinobacteria	C	SdhA B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC D which are the membrane components and form cytochrome b556	sdhA	-	1.3.5.1,1.3.5.4,1.4.3.16	ko:K00239,ko:K00278	ko00020,ko00190,ko00250,ko00650,ko00720,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00250,map00650,map00720,map00760,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00115,M00149,M00173,M00374,M00376	R00357,R00481,R02164	RC00006,RC00045,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_1247686_2	1227739.Hsw_1189	5.98e-66	207.0	COG0479@1|root,COG0479@2|Bacteria,4NFR3@976|Bacteroidetes,47KHR@768503|Cytophagia	976|Bacteroidetes	C	TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein	frdB	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_7,Fer4_8
k59_1690768_1	43759.JNWK01000016_gene272	8.52e-66	215.0	COG1409@1|root,COG1409@2|Bacteria,2IM97@201174|Actinobacteria	201174|Actinobacteria	S	Calcineurin-like phosphoesterase	-	-	3.1.3.1	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	Metallophos
k59_1024319_1	240015.ACP_1259	1.71e-17	85.9	COG0745@1|root,COG0745@2|Bacteria,3Y2ZE@57723|Acidobacteria,2JINH@204432|Acidobacteriia	204432|Acidobacteriia	K	Two component transcriptional regulator, winged helix family	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
k59_745778_1	1123234.AUKI01000017_gene2506	1.32e-05	49.3	COG2367@1|root,COG2367@2|Bacteria,4NDYP@976|Bacteroidetes,1I5UQ@117743|Flavobacteriia	976|Bacteroidetes	V	Beta-lactamase enzyme family	-	-	3.5.2.6	ko:K17836	ko00311,ko01130,ko01501,map00311,map01130,map01501	M00627,M00628	R06363	RC01499	ko00000,ko00001,ko00002,ko01000,ko01504	-	-	-	Beta-lactamase2
k59_745778_2	313606.M23134_06996	1.52e-19	90.1	COG0308@1|root,COG0308@2|Bacteria,4NGUB@976|Bacteroidetes,47K4K@768503|Cytophagia	976|Bacteroidetes	E	Peptidase M1, membrane alanine aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
k59_968295_1	1123371.ATXH01000029_gene45	1.15e-64	218.0	COG0380@1|root,COG1877@1|root,COG0380@2|Bacteria,COG1877@2|Bacteria,2GH2W@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	G	Trehalose-phosphatase	-	-	2.4.1.15,3.1.3.12	ko:K16055	ko00500,ko01100,map00500,map01100	-	R02737,R02778	RC00005,RC00017,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT20	-	Glyco_transf_20,Trehalose_PPase
k59_1357342_2	585531.HMPREF0063_11206	1.34e-17	87.8	COG0611@1|root,COG0611@2|Bacteria,2GP6E@201174|Actinobacteria,4DNV9@85009|Propionibacteriales	201174|Actinobacteria	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	GO:0008150,GO:0040007	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2977c	AIRS,AIRS_C
k59_855694_1	375286.mma_3469	6.91e-44	162.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2VH16@28216|Betaproteobacteria,4730A@75682|Oxalobacteraceae	28216|Betaproteobacteria	F	DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation	deaD	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
k59_1247720_1	2340.JV46_18360	6.66e-83	253.0	COG0755@1|root,COG0755@2|Bacteria,1MU61@1224|Proteobacteria,1RP3R@1236|Gammaproteobacteria,1J54R@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	U	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	ccmC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008152,GO:0015886,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051181,GO:0051234,GO:0055114,GO:0071702,GO:0071705,GO:0071944,GO:1901678	-	ko:K02195	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	iECDH1ME8569_1439.ECDH1ME8569_2134,iSFV_1184.SFV_2275,iSFxv_1172.SFxv_2517,iUTI89_1310.UTI89_C2477,ic_1306.c2736	Cytochrom_C_asm
k59_1745736_3	748449.Halha_1257	1.28e-06	51.2	COG0007@1|root,COG1587@1|root,COG0007@2|Bacteria,COG1587@2|Bacteria,1TQNH@1239|Firmicutes,2487I@186801|Clostridia,3WB33@53433|Halanaerobiales	186801|Clostridia	H	Belongs to the precorrin methyltransferase family	cobA	-	1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4	ko:K02302,ko:K02303,ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03165,R03194,R03947	RC00003,RC00871,RC01012,RC01034,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS15755	HEM4,Porphobil_deam,Porphobil_deamC,TP_methylase
k59_355851_1	243090.RB950	1.69e-45	162.0	COG0531@1|root,COG0531@2|Bacteria,2IXT5@203682|Planctomycetes	203682|Planctomycetes	E	PFAM Amino acid permease	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
k59_1523934_1	639030.JHVA01000001_gene2224	2.43e-91	282.0	COG3285@1|root,COG3285@2|Bacteria,3Y715@57723|Acidobacteria,2JM5P@204432|Acidobacteriia	204432|Acidobacteriia	L	dna ligase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_300942_2	985665.HPL003_03185	5.34e-27	106.0	COG3638@1|root,COG3638@2|Bacteria,1TQG6@1239|Firmicutes,4HC3N@91061|Bacilli,26S0C@186822|Paenibacillaceae	91061|Bacilli	P	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system	phnC	GO:0006810,GO:0008150,GO:0015716,GO:0051179,GO:0051234,GO:0071702	3.6.3.28	ko:K02041	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.9	-	-	ABC_tran
k59_189364_1	196162.Noca_0247	0.000106	51.2	COG2203@1|root,COG4251@1|root,COG2203@2|Bacteria,COG4251@2|Bacteria,2I5BB@201174|Actinobacteria,4DWYM@85009|Propionibacteriales	201174|Actinobacteria	T	PFAM ATP-binding region, ATPase domain protein domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
k59_1523965_1	317619.ANKN01000143_gene3679	3.1e-83	275.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,1G2E2@1117|Cyanobacteria,1MMDC@1212|Prochloraceae	1117|Cyanobacteria	C	Pyruvate:ferredoxin oxidoreductase core domain II	nifJ	GO:0003674,GO:0003824,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0016491,GO:0050896,GO:0055114	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iJN678.nifJ	EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_1468631_1	760192.Halhy_0465	4.67e-100	300.0	COG0620@1|root,COG0620@2|Bacteria,4NJAH@976|Bacteroidetes,1IZXY@117747|Sphingobacteriia	976|Bacteroidetes	E	COGs COG0620 Methionine synthase II (cobalamin-independent)	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
k59_968401_1	1379270.AUXF01000003_gene3439	1.83e-63	216.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1ZSNX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	EU	Dipeptidyl peptidase IV (DPP IV) N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	DPPIV_N,PD40,Peptidase_S9
k59_1190506_1	404589.Anae109_1724	1.39e-82	275.0	COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,42Q75@68525|delta/epsilon subdivisions,2WMDY@28221|Deltaproteobacteria,2YU11@29|Myxococcales	28221|Deltaproteobacteria	L	DEAD DEAH box	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
k59_300970_1	1198232.CYCME_1141	1.6e-05	48.5	COG1075@1|root,COG1075@2|Bacteria,1N2W0@1224|Proteobacteria,1S2JW@1236|Gammaproteobacteria,463TN@72273|Thiotrichales	72273|Thiotrichales	S	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_23061_1	1380394.JADL01000001_gene2883	8.5e-177	516.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2TS19@28211|Alphaproteobacteria,2JQ7S@204441|Rhodospirillales	204441|Rhodospirillales	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC,Ribonuc_red_lgN
k59_1135354_1	861299.J421_4436	1.41e-66	226.0	COG2866@1|root,COG2866@2|Bacteria,1ZSMP@142182|Gemmatimonadetes	2|Bacteria	E	Zinc carboxypeptidase	-	-	-	ko:K14054	-	-	-	-	ko00000	-	-	-	AstE_AspA,Peptidase_M14
k59_1598775_2	880073.Calab_0983	1.4e-30	111.0	COG0011@1|root,COG0011@2|Bacteria,2NQ69@2323|unclassified Bacteria	2|Bacteria	S	Thiamine-binding protein	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	Thiamine_BP
k59_1487784_2	1120965.AUBV01000006_gene2303	7.15e-36	135.0	COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,4NFUJ@976|Bacteroidetes,47JSR@768503|Cytophagia	976|Bacteroidetes	C	Phosphate acetyl butaryl transferase	maeB	-	1.1.1.38,1.1.1.40	ko:K00027,ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,ko02020,map00620,map00710,map01100,map01120,map01200,map02020	M00169,M00172	R00214,R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,PTA_PTB,malic
k59_1541382_1	309801.trd_1490	1.43e-15	72.4	COG1917@1|root,COG1917@2|Bacteria,2G9S4@200795|Chloroflexi,27ZAD@189775|Thermomicrobia	189775|Thermomicrobia	S	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_1541382_2	756883.Halar_1275	2.92e-08	52.4	COG0607@1|root,arCOG02021@2157|Archaea	2157|Archaea	P	COG0607 Rhodanese-related sulfurtransferase	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
k59_96915_1	224325.AF_0767	7.13e-56	179.0	COG0105@1|root,arCOG04313@2157|Archaea,2XWSK@28890|Euryarchaeota,2465T@183980|Archaeoglobi	183980|Archaeoglobi	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
k59_320799_1	1056816.JAFQ01000004_gene4740	3.53e-17	87.4	COG0477@1|root,COG0477@2|Bacteria,2HPSS@201174|Actinobacteria	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1431291_1	246197.MXAN_3837	9.64e-08	59.3	COG0457@1|root,COG0664@1|root,COG0457@2|Bacteria,COG0664@2|Bacteria,1N1ZG@1224|Proteobacteria,4336W@68525|delta/epsilon subdivisions,2WYCK@28221|Deltaproteobacteria,2YXD4@29|Myxococcales	28221|Deltaproteobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
k59_651019_1	314278.NB231_00455	7.41e-49	170.0	COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,1RNAZ@1236|Gammaproteobacteria,1WWPS@135613|Chromatiales	135613|Chromatiales	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
k59_1044644_1	204669.Acid345_3130	1.43e-29	112.0	COG1392@1|root,COG1392@2|Bacteria,3Y58U@57723|Acidobacteria,2JK4H@204432|Acidobacteriia	204432|Acidobacteriia	P	Protein of unknown function DUF47	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
k59_1044644_2	997346.HMPREF9374_1953	6.33e-13	67.8	COG0306@1|root,COG0306@2|Bacteria,1TQ3D@1239|Firmicutes,4HAPD@91061|Bacilli,27BNU@186824|Thermoactinomycetaceae	91061|Bacilli	P	Phosphate transporter family	pit	GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
k59_151944_1	645465.ACUR01000524_gene2381	2.04e-33	124.0	COG1174@1|root,COG1174@2|Bacteria,2GYTC@201174|Actinobacteria	201174|Actinobacteria	E	ABC transporter (Permease)	proW	-	-	ko:K05846	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1
k59_1208673_1	1380370.JIBA01000019_gene1012	8.6e-07	54.3	COG1009@1|root,COG1009@2|Bacteria,2GIT4@201174|Actinobacteria,4FEJ4@85021|Intrasporangiaceae	201174|Actinobacteria	CP	NADH ubiquinone oxidoreductase subunit	nuoL	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
k59_1208673_2	717605.Theco_3847	1.62e-13	72.0	COG1008@1|root,COG1008@2|Bacteria,1UHSH@1239|Firmicutes,4IS87@91061|Bacilli,26TJ2@186822|Paenibacillaceae	91061|Bacilli	C	proton-translocating NADH-quinone oxidoreductase, chain M	nuoM	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
k59_819745_1	446468.Ndas_4532	3.22e-14	74.3	COG1123@1|root,COG4172@2|Bacteria,2H3HY@201174|Actinobacteria,4ER7C@85012|Streptosporangiales	201174|Actinobacteria	P	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,BPD_transp_1,oligo_HPY
k59_1208692_1	1207076.ALAT01000200_gene1273	1.09e-70	243.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1Z21A@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	T	signal transduction protein containing a membrane domain, an EAL and a GGDEF domain	morA	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_8,PAS_9,dCache_2
k59_1267122_1	1121918.ARWE01000001_gene937	2.64e-130	393.0	COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,42N1H@68525|delta/epsilon subdivisions,2WJ0R@28221|Deltaproteobacteria,43SBR@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Inorganic H+ pyrophosphatase	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
k59_1711204_2	3218.PP1S220_23V6.1	1.84e-26	109.0	COG0306@1|root,KOG2493@2759|Eukaryota,37MAB@33090|Viridiplantae,3GGPC@35493|Streptophyta	35493|Streptophyta	P	Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport	-	GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0008509,GO:0009507,GO:0009526,GO:0009536,GO:0009673,GO:0009941,GO:0015075,GO:0015103,GO:0015114,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0031967,GO:0031975,GO:0034220,GO:0035435,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044425,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661	-	ko:K14640	-	-	-	-	ko00000,ko02000	2.A.20.2	-	-	PHO4
k59_1651655_2	1122132.AQYH01000004_gene1546	1.11e-30	117.0	COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,2TQT3@28211|Alphaproteobacteria,4B82E@82115|Rhizobiaceae	28211|Alphaproteobacteria	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Radical_SAM
k59_1487862_1	469383.Cwoe_1850	3.89e-37	130.0	COG1310@1|root,COG1310@2|Bacteria,2IFB5@201174|Actinobacteria,4CQGR@84995|Rubrobacteria	84995|Rubrobacteria	S	JAB/MPN domain	-	-	3.13.1.6	ko:K21140	ko04122,map04122	-	R11524	RC00064,RC00090	ko00000,ko00001,ko01000	-	-	-	Prok-JAB
k59_1487862_2	1382306.JNIM01000001_gene3473	1.22e-65	208.0	COG2897@1|root,COG2897@2|Bacteria,2G5XI@200795|Chloroflexi	200795|Chloroflexi	P	PFAM Rhodanese domain protein	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
k59_1376552_1	1121904.ARBP01000001_gene5864	1.77e-104	315.0	COG3669@1|root,COG3669@2|Bacteria,4NE74@976|Bacteroidetes,47KQM@768503|Cytophagia	976|Bacteroidetes	G	Alpha-L-fucosidase	fucA	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos
k59_596731_1	204669.Acid345_3782	5.6e-50	171.0	COG1660@1|root,COG1660@2|Bacteria,3Y2HM@57723|Acidobacteria,2JHJM@204432|Acidobacteriia	204432|Acidobacteriia	S	Displays ATPase and GTPase activities	-	-	-	ko:K06958	-	-	-	-	ko00000,ko03019	-	-	-	ATP_bind_2
k59_488166_1	1192034.CAP_7995	9.1e-50	168.0	COG0332@1|root,COG0332@2|Bacteria,1NSH9@1224|Proteobacteria,42Z79@68525|delta/epsilon subdivisions,2WUD8@28221|Deltaproteobacteria,2YUSN@29|Myxococcales	28221|Deltaproteobacteria	I	3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
k59_541606_1	293826.Amet_1165	2.21e-20	94.0	COG2206@1|root,COG2206@2|Bacteria,1V1J0@1239|Firmicutes,24FUR@186801|Clostridia,36FET@31979|Clostridiaceae	186801|Clostridia	T	PFAM Metal-dependent phosphohydrolase, HD	-	-	-	-	-	-	-	-	-	-	-	-	HD,HD_5
k59_152010_1	2880.D8LJU0	3.89e-09	58.2	COG0461@1|root,KOG1377@2759|Eukaryota	2759|Eukaryota	F	'de novo' UMP biosynthetic process	URA5	GO:0003674,GO:0003824,GO:0004588,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006213,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019856,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046112,GO:0046131,GO:0046132,GO:0046134,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.1.1.202,2.4.2.10,4.1.1.23	ko:K00762,ko:K01591,ko:K13421,ko:K15334	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00051	R00965,R01870,R08231	RC00063,RC00409,RC00611	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	OMPdecase,Pribosyltran
k59_152010_2	5679.XP_010697582.1	6.8e-60	201.0	COG0461@1|root,KOG1377@2759|Eukaryota,3XSWC@5653|Kinetoplastida	5653|Kinetoplastida	F	Orotidine-5-phosphate decarboxylase orotate phosphoribosyltransferase	-	-	2.4.2.10,4.1.1.23	ko:K01591,ko:K13421	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00051	R00965,R01870,R08231	RC00063,RC00409,RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase,Pribosyltran
k59_541623_1	1283283.ATXA01000001_gene375	3.17e-23	94.0	COG3795@1|root,COG3795@2|Bacteria,2IKRD@201174|Actinobacteria,4ET7H@85013|Frankiales	201174|Actinobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
k59_1763075_2	266779.Meso_2288	6.01e-15	69.3	COG0607@1|root,32YCZ@2|Bacteria,1N6NN@1224|Proteobacteria,2UFC1@28211|Alphaproteobacteria,43M28@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	Sulfurtransferase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
k59_320898_1	653733.Selin_2168	2.5e-97	293.0	COG3221@1|root,COG3221@2|Bacteria	2|Bacteria	P	organic phosphonate transport	phnD	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	Phosphonate-bd
k59_874803_1	1379698.RBG1_1C00001G1654	1.14e-69	226.0	COG0606@1|root,COG0606@2|Bacteria,2NNW7@2323|unclassified Bacteria	2|Bacteria	O	Magnesium chelatase, subunit ChlI C-terminal	comM	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
k59_1098408_1	379066.GAU_3308	1.24e-66	217.0	COG2234@1|root,COG2234@2|Bacteria,1ZTDG@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
k59_541639_2	1122179.KB890458_gene789	1.06e-09	63.5	COG1028@1|root,COG1028@2|Bacteria,4NH6R@976|Bacteroidetes,1IP1M@117747|Sphingobacteriia	976|Bacteroidetes	IQ	Short-chain dehydrogenase reductase sdr	-	-	1.1.1.100	ko:K00059,ko:K18333	ko00051,ko00061,ko00333,ko00780,ko01040,ko01100,ko01120,ko01130,ko01212,map00051,map00061,map00333,map00780,map01040,map01100,map01120,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R08926,R10116,R10120,R11671	RC00029,RC00066,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_1044721_1	665029.EAMY_3430	8.24e-08	56.6	COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,1RN4I@1236|Gammaproteobacteria,3X58S@551|Erwinia	1236|Gammaproteobacteria	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	GO:0000166,GO:0003674,GO:0003824,GO:0003856,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0051287,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.2.3.4	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03083	RC00847	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b3389,iBWG_1329.BWG_3080,iECDH10B_1368.ECDH10B_3564,iECDH1ME8569_1439.ECDH1ME8569_3268,iECNA114_1301.ECNA114_3486,iEcDH1_1363.EcDH1_0324,iJO1366.b3389,iJR904.b3389,iY75_1357.Y75_RS20275	DHQ_synthase
k59_1044721_2	1196323.ALKF01000193_gene3321	3.66e-28	106.0	COG0757@1|root,COG0757@2|Bacteria,1V6E8@1239|Firmicutes,4HJ2V@91061|Bacilli,26XJ0@186822|Paenibacillaceae	91061|Bacilli	E	Catalyzes a trans-dehydration via an enolate intermediate	aroQ	-	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
k59_1376603_1	1379270.AUXF01000002_gene1168	0.000613	43.5	COG1595@1|root,COG1595@2|Bacteria,1ZT2V@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	ECF sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_1376603_2	404589.Anae109_1512	2.42e-22	92.4	2CFSQ@1|root,32S2E@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1376619_2	272560.BPSS0157	4.78e-26	101.0	COG4319@1|root,COG4319@2|Bacteria,1RF3P@1224|Proteobacteria,2VUDI@28216|Betaproteobacteria	28216|Betaproteobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
k59_1376619_3	348824.LPU83_3607	7.28e-27	99.0	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,2UF6W@28211|Alphaproteobacteria,4BG0X@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	Cold shock	cspA1	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
k59_651139_1	314278.NB231_12074	1.58e-65	221.0	COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,1RNRX@1236|Gammaproteobacteria,1WXQF@135613|Chromatiales	135613|Chromatiales	P	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
k59_320953_1	1395571.TMS3_0122465	1.4e-58	189.0	COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,1RN6F@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Electron transfer flavoprotein	etfB	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
k59_430452_1	1394178.AWOO02000029_gene4656	2.37e-73	236.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4EG29@85012|Streptosporangiales	201174|Actinobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_320967_1	1353531.AZNX01000006_gene5668	7.05e-23	104.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2TR2P@28211|Alphaproteobacteria,4B9EZ@82115|Rhizobiaceae	28211|Alphaproteobacteria	V	ABC transporter, ATP-binding protein	ybhF	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006855,GO:0008150,GO:0015562,GO:0015893,GO:0016020,GO:0022857,GO:0042221,GO:0042493,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1651789_2	765420.OSCT_2995	1.24e-52	174.0	COG0662@1|root,COG1396@1|root,COG0662@2|Bacteria,COG1396@2|Bacteria,2G7GS@200795|Chloroflexi	200795|Chloroflexi	K	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_3
k59_988478_2	253839.SSNG_00548	1.41e-50	168.0	COG0235@1|root,COG0235@2|Bacteria,2GNI6@201174|Actinobacteria	201174|Actinobacteria	G	PFAM class II aldolase adducin family protein	araD	-	5.1.3.4	ko:K03077	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	M00550	R05850	RC01479	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase_II
k59_206601_1	696747.NIES39_L03460	2.21e-43	157.0	COG0128@1|root,COG0128@2|Bacteria,1G1F9@1117|Cyanobacteria,1H72W@1150|Oscillatoriales	1117|Cyanobacteria	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
k59_40670_1	765420.OSCT_2174	1.07e-88	266.0	COG0455@1|root,COG0455@2|Bacteria,2G9ZU@200795|Chloroflexi,3772G@32061|Chloroflexia	32061|Chloroflexia	D	NUBPL iron-transfer P-loop NTPase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_31
k59_1044792_1	224325.AF_0176	8.36e-46	166.0	COG1153@1|root,COG5013@1|root,arCOG01497@2157|Archaea,arCOG02674@2157|Archaea,2XTNG@28890|Euryarchaeota,246NS@183980|Archaeoglobi	183980|Archaeoglobi	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_40673_1	547559.Nmag_2903	1.44e-15	83.6	COG4666@1|root,arCOG01906@2157|Archaea,2XT7X@28890|Euryarchaeota,23SN3@183963|Halobacteria	183963|Halobacteria	S	transport system, fused permease components	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_40673_2	1380394.JADL01000002_gene1729	2.78e-05	45.8	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2TQVK@28211|Alphaproteobacteria,2JUZD@204441|Rhodospirillales	204441|Rhodospirillales	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C2
k59_40689_1	543728.Vapar_2796	3.93e-49	169.0	COG0590@1|root,COG0596@1|root,COG0590@2|Bacteria,COG0596@2|Bacteria,1RGU0@1224|Proteobacteria,2VR60@28216|Betaproteobacteria,4A9VR@80864|Comamonadaceae	28216|Betaproteobacteria	FJ	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	-	3.5.4.33,3.8.1.5	ko:K01563,ko:K11991	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05284,R05367,R05368,R05369,R05370,R07669,R07670,R10223	RC00477,RC01317,RC01340,RC01341,RC02013	ko00000,ko00001,ko01000,ko03016	-	-	-	Abhydrolase_1,MafB19-deam,TfoX_C
k59_40689_2	1122925.KB895391_gene1553	3.37e-12	70.9	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1UZ1E@1239|Firmicutes,4HF6K@91061|Bacilli,26R0Y@186822|Paenibacillaceae	91061|Bacilli	T	AraC family transcriptional regulator	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,Response_reg
k59_1376700_2	398525.KB900701_gene7385	6.26e-69	222.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,3JUV3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Aldehyde dehydrogenase family	MA20_08220	-	-	ko:K22187	ko00040,map00040	-	R11768	RC00080	ko00000,ko00001,ko01000	-	-	-	Aldedh
k59_206628_1	749927.AMED_1943	1.62e-33	134.0	COG2844@1|root,COG2844@2|Bacteria,2GMKT@201174|Actinobacteria,4DXG4@85010|Pseudonocardiales	201174|Actinobacteria	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008773,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0030312,GO:0044464,GO:0070566,GO:0070569,GO:0071944,GO:0140096	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,GlnD_UR_UTase,HD,NTP_transf_2
k59_934170_1	1123279.ATUS01000001_gene1937	4.11e-09	62.8	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,1RMPS@1236|Gammaproteobacteria,1J54X@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	GO:0003674,GO:0003824,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0052855,GO:0052856,GO:0052857	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
k59_874934_1	375451.RD1_3781	3.17e-63	207.0	COG1679@1|root,COG1679@2|Bacteria,1NFH4@1224|Proteobacteria,2TTR6@28211|Alphaproteobacteria,2P4IC@2433|Roseobacter	28211|Alphaproteobacteria	S	Protein of unknown function (DUF521)	-	-	-	ko:K09123	-	-	-	-	ko00000	-	-	-	DUF521
k59_819932_1	1304885.AUEY01000003_gene474	1.16e-30	126.0	COG0515@1|root,COG0642@1|root,COG3899@1|root,COG5002@1|root,COG0515@2|Bacteria,COG0642@2|Bacteria,COG3899@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,42NK9@68525|delta/epsilon subdivisions	1224|Proteobacteria	T	Response regulator receiver	-	-	2.7.13.3	ko:K07678	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	M00475	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	AAA_16,GAF,HAMP,HATPase_c,HisKA,Hpt,PAS_3,PAS_4,PAS_8,PAS_9,Pkinase,Response_reg,SBP_bac_3
k59_97167_1	1120983.KB894571_gene2469	1.95e-12	68.9	COG0683@1|root,COG0683@2|Bacteria,1NHBN@1224|Proteobacteria,2TWTC@28211|Alphaproteobacteria,1JPE5@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	Periplasmic binding protein domain	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_40705_1	1120988.AXWV01000043_gene945	8.78e-56	194.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RME8@1236|Gammaproteobacteria,1Y3RQ@135624|Aeromonadales	135624|Aeromonadales	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_651214_1	861299.J421_3080	4.35e-101	304.0	COG0206@1|root,COG0206@2|Bacteria,1ZSNH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
k59_375264_1	443143.GM18_2768	1.74e-15	79.0	COG4584@1|root,COG4584@2|Bacteria,1MW5J@1224|Proteobacteria,42X93@68525|delta/epsilon subdivisions,2WSXR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_1713798_1	861299.J421_6188	1.57e-19	94.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_154978_1	530564.Psta_2436	2.07e-42	155.0	COG1530@1|root,COG1530@2|Bacteria,2IWSS@203682|Planctomycetes	203682|Planctomycetes	J	TIGRFAM ribonuclease, Rne Rng family	rne	-	3.1.26.12	ko:K08300	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
k59_1324750_1	388413.ALPR1_05285	1.48e-16	77.4	COG2153@1|root,COG2153@2|Bacteria,4NT5M@976|Bacteroidetes,47Q2T@768503|Cytophagia	976|Bacteroidetes	S	PFAM Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
k59_1324750_2	1123060.JONP01000046_gene5297	3.12e-21	89.4	COG1853@1|root,COG1853@2|Bacteria,1MUPP@1224|Proteobacteria,2TT7S@28211|Alphaproteobacteria,2JS18@204441|Rhodospirillales	204441|Rhodospirillales	S	COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
k59_1284084_1	1002672.SAR11G3_00407	1.66e-05	46.2	COG0118@1|root,COG0118@2|Bacteria,1MU4X@1224|Proteobacteria,2TTT4@28211|Alphaproteobacteria,4BQA9@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
k59_1284084_2	999541.bgla_1g03810	2.19e-48	164.0	COG0106@1|root,COG0106@2|Bacteria,1MW6S@1224|Proteobacteria,2VI38@28216|Betaproteobacteria,1K1DU@119060|Burkholderiaceae	28216|Betaproteobacteria	E	1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase	hisA	GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
k59_172182_1	526227.Mesil_0436	4.52e-30	120.0	COG0002@1|root,COG0002@2|Bacteria,1WIZ3@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Catalyzes the NADPH-dependent reduction of LysW - aminoadipate 6-phosphate to yield LysW -aminoadipate 6- semialdehyde	lysY	-	-	ko:K05829	ko00220,ko00300,ko01100,ko01110,ko01210,ko01230,map00220,map00300,map01100,map01110,map01210,map01230	M00031,M00763	R09777,R10931	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
k59_1229050_1	1121924.ATWH01000011_gene311	3.73e-56	186.0	COG0395@1|root,COG0395@2|Bacteria,2GNQW@201174|Actinobacteria,4FM4U@85023|Microbacteriaceae	201174|Actinobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K10119	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
k59_1229050_2	1120949.KB903328_gene8860	1.2e-07	52.4	COG1175@1|root,COG1175@2|Bacteria,2GKJI@201174|Actinobacteria,4DIFW@85008|Micromonosporales	201174|Actinobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K10118	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
k59_1172854_1	909613.UO65_5487	1.3e-10	67.4	COG2208@1|root,COG2208@2|Bacteria,2GNG4@201174|Actinobacteria,4E0KW@85010|Pseudonocardiales	201174|Actinobacteria	KT	PFAM Stage II sporulation protein E (SpoIIE)	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIE
k59_1229056_1	1521187.JPIM01000053_gene2947	1.62e-33	131.0	COG2304@1|root,COG2304@2|Bacteria,2G8H5@200795|Chloroflexi,374V6@32061|Chloroflexia	32061|Chloroflexia	S	PFAM von Willebrand factor type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA
k59_561155_1	997346.HMPREF9374_2960	3.77e-53	187.0	COG2183@1|root,COG2183@2|Bacteria,1TPFE@1239|Firmicutes,4HAGY@91061|Bacilli,27BN9@186824|Thermoactinomycetaceae	91061|Bacilli	K	Tex-like protein N-terminal domain	tex	-	-	ko:K06959	-	-	-	-	ko00000	-	-	-	HHH_3,S1,Tex_N,Tex_YqgF
k59_1284099_1	986075.CathTA2_3069	8.63e-59	193.0	COG0502@1|root,COG0502@2|Bacteria,1TPQ4@1239|Firmicutes,4HAGM@91061|Bacilli	91061|Bacilli	H	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism	bioB	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	BATS,Radical_SAM
k59_1284099_2	1123023.JIAI01000001_gene6131	4.76e-08	57.0	COG5485@1|root,COG5485@2|Bacteria	2|Bacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL,SnoaL_2
k59_394589_1	591159.ACEZ01000226_gene1023	6.28e-43	153.0	COG2851@1|root,COG2851@2|Bacteria,2GNWE@201174|Actinobacteria	201174|Actinobacteria	C	Citrate transporter	-	-	-	ko:K03300	-	-	-	-	ko00000	2.A.11	-	-	CitMHS
k59_394589_2	710687.KI912270_gene2188	6.54e-15	74.7	COG1804@1|root,COG1804@2|Bacteria,2GMIW@201174|Actinobacteria,234BA@1762|Mycobacteriaceae	201174|Actinobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_61069_1	511.JT27_08395	2.94e-64	210.0	COG4597@1|root,COG4597@2|Bacteria,1MV0S@1224|Proteobacteria,2VIDZ@28216|Betaproteobacteria,3T2AT@506|Alcaligenaceae	28216|Betaproteobacteria	P	COG4597 ABC-type amino acid transport system, permease component	aapQ	-	-	ko:K09970	ko02010,map02010	M00232	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	BPD_transp_1
k59_1506411_1	1379270.AUXF01000001_gene2615	3.02e-31	127.0	COG0587@1|root,COG0587@2|Bacteria,1ZU9R@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Helix-hairpin-helix motif	-	-	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_1673282_1	35754.JNYJ01000046_gene3102	6.72e-75	241.0	COG1520@1|root,COG1520@2|Bacteria,2I9S4@201174|Actinobacteria,4D97G@85008|Micromonosporales	201174|Actinobacteria	S	beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
k59_1006294_2	6500.XP_005090929.1	1.36e-24	100.0	COG0321@1|root,KOG0325@2759|Eukaryota,39TS9@33154|Opisthokonta,3BPH7@33208|Metazoa,3D23A@33213|Bilateria	33208|Metazoa	CH	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	LIPT2	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009893,GO:0009987,GO:0010467,GO:0016740,GO:0016746,GO:0016747,GO:0018065,GO:0018193,GO:0018205,GO:0019222,GO:0019538,GO:0031323,GO:0031325,GO:0031974,GO:0033819,GO:0034641,GO:0036211,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051604,GO:0065007,GO:0070013,GO:0071704,GO:1901564,GO:2000374,GO:2000376	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
k59_172213_1	1242864.D187_004067	3.14e-16	81.6	COG3055@1|root,COG3055@2|Bacteria,1MYQG@1224|Proteobacteria,42P3T@68525|delta/epsilon subdivisions,2WKUC@28221|Deltaproteobacteria,2YWZJ@29|Myxococcales	28221|Deltaproteobacteria	S	Kelch motif	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_1,Kelch_4
k59_1117621_2	1122134.KB893650_gene1181	4.34e-18	83.6	COG1446@1|root,COG1446@2|Bacteria,1MWFC@1224|Proteobacteria,1RNUR@1236|Gammaproteobacteria,1XJDY@135619|Oceanospirillales	135619|Oceanospirillales	E	Asparaginase	-	-	3.4.19.5	ko:K13051	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Asparaginase_2
k59_1506428_1	671143.DAMO_3012	8.85e-104	309.0	COG2805@1|root,COG2805@2|Bacteria,2NNR7@2323|unclassified Bacteria	2|Bacteria	NU	Type II/IV secretion system protein	pilT	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
k59_1229089_2	648757.Rvan_3065	2.02e-06	52.0	COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,2U0K2@28211|Alphaproteobacteria,3N6RA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Ami_3	amiC	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3
k59_1673303_2	926569.ANT_13990	2.77e-22	94.7	COG0524@1|root,COG0524@2|Bacteria,2G6PQ@200795|Chloroflexi	200795|Chloroflexi	G	PFAM PfkB domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
k59_227921_1	314285.KT71_06247	9.03e-55	194.0	COG5616@1|root,COG5616@2|Bacteria,1NSKC@1224|Proteobacteria,1S876@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1229096_1	550540.Fbal_3096	1.02e-05	52.4	COG3595@1|root,COG3595@2|Bacteria,1RI1P@1224|Proteobacteria,1RRZW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
k59_1673309_1	404589.Anae109_3715	2.78e-116	349.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,42M52@68525|delta/epsilon subdivisions,2WIRK@28221|Deltaproteobacteria,2YUQN@29|Myxococcales	28221|Deltaproteobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
k59_227925_1	861299.J421_2767	5.46e-79	264.0	COG0085@1|root,COG0085@2|Bacteria,1ZSQH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_505913_1	29306.JOBE01000011_gene7261	5.92e-16	84.3	COG3291@1|root,COG3291@2|Bacteria,2GJR2@201174|Actinobacteria	201174|Actinobacteria	S	Pkd domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBM_4_9
k59_338817_1	926569.ANT_12930	3.84e-43	152.0	COG0392@1|root,COG0392@2|Bacteria	2|Bacteria	M	lysyltransferase activity	mprF	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
k59_5682_1	1298858.AUEL01000013_gene5054	2.27e-45	163.0	COG4962@1|root,COG4962@2|Bacteria,1R7EN@1224|Proteobacteria,2TRNT@28211|Alphaproteobacteria,43H3N@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	U	pilus assembly protein ATPase CpaF	cpaF	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
k59_1617570_1	1121104.AQXH01000004_gene88	7.34e-12	71.6	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec
k59_1229143_1	1120960.ATXG01000028_gene2711	6.95e-35	131.0	COG0609@1|root,COG0609@2|Bacteria,2GK8Z@201174|Actinobacteria,4FMIS@85023|Microbacteriaceae	201174|Actinobacteria	P	FecCD transport family	znuB1	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
k59_1229143_2	335543.Sfum_2391	7.46e-09	58.5	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42MV1@68525|delta/epsilon subdivisions,2WK9W@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	PFAM ABC transporter	-	-	-	ko:K01990,ko:K01992,ko:K09695	ko02010,map02010	M00252,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.102	-	-	ABC2_membrane_3,ABC_tran
k59_1006355_1	1121935.AQXX01000138_gene3121	9.58e-43	155.0	COG0471@1|root,COG0569@1|root,COG0471@2|Bacteria,COG0569@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,1XHSW@135619|Oceanospirillales	135619|Oceanospirillales	P	COG0471 Di- and tricarboxylate transporters	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,TrkA_C
k59_1617593_1	671143.DAMO_3055	6.29e-44	164.0	COG0577@1|root,COG4591@1|root,COG0577@2|Bacteria,COG4591@2|Bacteria,2NQQA@2323|unclassified Bacteria	2|Bacteria	V	MacB-like periplasmic core domain	lolE-2	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_116591_1	591159.ACEZ01000014_gene790	1.71e-16	80.1	COG4941@1|root,COG4941@2|Bacteria,2GJ36@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_116591_2	1385521.N803_03905	1.41e-40	140.0	2AP53@1|root,32UTP@2|Bacteria,2I8BG@201174|Actinobacteria,4FG4B@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_895250_1	1267533.KB906735_gene4596	1.2e-37	137.0	COG0500@1|root,COG2226@2|Bacteria,3Y46W@57723|Acidobacteria,2JIFG@204432|Acidobacteriia	204432|Acidobacteriia	Q	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_1395329_1	309807.SRU_0542	1.26e-46	160.0	COG0115@1|root,COG0115@2|Bacteria,4NI83@976|Bacteroidetes	976|Bacteroidetes	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.21	ko:K00824	ko00310,ko00330,ko00360,ko00472,ko00473,ko01100,map00310,map00330,map00360,map00472,map00473,map01100	-	R01148,R01582,R02459,R02851,R02924,R05053	RC00006,RC00008,RC00025	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_4
k59_1395330_2	96561.Dole_0808	2.09e-36	134.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42PIB@68525|delta/epsilon subdivisions,2WKFC@28221|Deltaproteobacteria,2MMZK@213118|Desulfobacterales	28221|Deltaproteobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1451233_1	1121448.DGI_0382	1.93e-25	100.0	COG3324@1|root,COG3324@2|Bacteria,1R81W@1224|Proteobacteria,43B97@68525|delta/epsilon subdivisions,2X6NG@28221|Deltaproteobacteria,2MH4V@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	-
k59_1172964_1	309801.trd_A0017	3.85e-20	89.0	COG0606@1|root,COG0606@2|Bacteria,2G65P@200795|Chloroflexi,27Y2X@189775|Thermomicrobia	189775|Thermomicrobia	O	Magnesium chelatase, subunit ChlI	-	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
k59_1172964_2	765420.OSCT_0637	3.95e-15	75.9	COG0606@1|root,COG0606@2|Bacteria,2G65P@200795|Chloroflexi,37511@32061|Chloroflexia	32061|Chloroflexia	O	PFAM magnesium chelatase ChlI subunit	-	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
k59_1229188_1	379066.GAU_0856	1.77e-112	361.0	COG0086@1|root,COG0303@1|root,COG0086@2|Bacteria,COG0303@2|Bacteria,1ZSZQ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_895271_1	263358.VAB18032_12245	6.08e-68	225.0	COG0468@1|root,COG1372@1|root,COG0468@2|Bacteria,COG1372@2|Bacteria,2GJ4P@201174|Actinobacteria,4DAV3@85008|Micromonosporales	201174|Actinobacteria	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	GO:0000150,GO:0000166,GO:0000287,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009650,GO:0009987,GO:0009991,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030145,GO:0030554,GO:0031668,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042148,GO:0042221,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
k59_505996_1	927677.ALVU02000002_gene292	1.27e-105	314.0	COG3039@1|root,COG3039@2|Bacteria,1G1EK@1117|Cyanobacteria	1117|Cyanobacteria	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_3
k59_1061760_2	1469245.JFBG01000052_gene2167	1.17e-73	228.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,1RMK8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Branched-chain amino acid transport	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
k59_228030_1	861299.J421_2893	2.2e-22	99.8	2F044@1|root,33T7T@2|Bacteria	861299.J421_2893|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1451261_1	1123269.NX02_08705	2.01e-72	219.0	COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,2U5Q0@28211|Alphaproteobacteria,2K40G@204457|Sphingomonadales	204457|Sphingomonadales	O	COG0229 Conserved domain frequently associated with peptide methionine sulfoxide reductase	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
k59_1451261_2	1121918.ARWE01000001_gene3369	6.47e-91	268.0	COG0225@1|root,COG0225@2|Bacteria,1MVUS@1224|Proteobacteria,42SZG@68525|delta/epsilon subdivisions,2WPQX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	-	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
k59_1506566_1	765869.BDW_00010	3.75e-21	93.2	COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,42NQW@68525|delta/epsilon subdivisions,2MSVN@213481|Bdellovibrionales,2WJZM@28221|Deltaproteobacteria	213481|Bdellovibrionales	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
k59_1061788_1	378806.STAUR_1290	3.76e-16	83.2	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,42MKS@68525|delta/epsilon subdivisions,2WKIH@28221|Deltaproteobacteria,2YVAF@29|Myxococcales	28221|Deltaproteobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_1173005_1	383372.Rcas_3309	1.84e-24	107.0	COG5001@1|root,COG5001@2|Bacteria,2G7UT@200795|Chloroflexi,3762V@32061|Chloroflexia	32061|Chloroflexia	T	PFAM GGDEF domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_3,PAS_4,Response_reg
k59_1117761_1	1183438.GKIL_4354	3.06e-08	58.2	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_1339875_1	690850.Desaf_0722	1.37e-12	73.6	COG2204@1|root,COG2204@2|Bacteria,1NSFC@1224|Proteobacteria,42Y7Y@68525|delta/epsilon subdivisions,2WU6N@28221|Deltaproteobacteria,2M9NX@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Sigma54_activat
k59_1506580_1	1449353.JQMQ01000005_gene3375	2.74e-29	112.0	COG0637@1|root,COG0637@2|Bacteria,2GMIQ@201174|Actinobacteria,2NEMV@228398|Streptacidiphilus	201174|Actinobacteria	S	HAD-hyrolase-like	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
k59_1728958_1	926569.ANT_14300	1.11e-61	194.0	COG2197@1|root,COG2197@2|Bacteria,2G80G@200795|Chloroflexi	200795|Chloroflexi	K	Two component transcriptional regulator, LuxR family	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_1728958_2	1453500.AT05_01460	3.38e-43	147.0	COG0223@1|root,COG0223@2|Bacteria	2|Bacteria	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	-	GO:0003674,GO:0003824,GO:0004479,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009405,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0042802,GO:0042803,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044419,GO:0046483,GO:0046983,GO:0051704,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.1.2.2,2.1.2.9	ko:K00604,ko:K11175	ko00230,ko00670,ko00970,ko01100,ko01110,ko01130,map00230,map00670,map00970,map01100,map01110,map01130	M00048	R03940,R04325,R04326	RC00026,RC00165,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N
k59_895330_1	1184251.TCELL_1088	2.51e-19	89.7	COG1529@1|root,arCOG01167@2157|Archaea,2XPS6@28889|Crenarchaeota	28889|Crenarchaeota	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0016903,GO:0043546,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0055114,GO:0097159,GO:1901363	1.2.5.3,1.2.99.8	ko:K03520,ko:K18020	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R10324,R11168	RC00242,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_338956_1	317025.Tcr_0338	9.22e-96	291.0	COG1680@1|root,COG1680@2|Bacteria,1P3SQ@1224|Proteobacteria,1RRMI@1236|Gammaproteobacteria,462ZC@72273|Thiotrichales	72273|Thiotrichales	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_1061816_1	1144325.PMI22_04378	2.43e-15	83.6	COG0477@1|root,COG2814@2|Bacteria,1MXKN@1224|Proteobacteria,1S1A0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
k59_1173035_1	665571.STHERM_c17370	1.63e-37	142.0	COG0265@1|root,COG0265@2|Bacteria,2J5GT@203691|Spirochaetes	203691|Spirochaetes	O	periplasmic serine protease, Do	htrA	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
k59_783909_1	926569.ANT_14270	2.6e-28	110.0	COG0022@1|root,COG0022@2|Bacteria,2G60F@200795|Chloroflexi	200795|Chloroflexi	C	PFAM Transketolase central region	-	-	1.2.4.1,1.2.4.4	ko:K00162,ko:K11381,ko:K21417	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
k59_783909_2	882082.SaccyDRAFT_2213	3.03e-16	80.5	COG0508@1|root,COG0508@2|Bacteria,2GN5J@201174|Actinobacteria,4E13H@85010|Pseudonocardiales	201174|Actinobacteria	C	acetyltransferase component of pyruvate dehydrogenase complex	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_61269_1	1408813.AYMG01000012_gene1057	2.06e-88	283.0	COG3254@1|root,COG3420@1|root,COG3254@2|Bacteria,COG3420@2|Bacteria,4NF5Y@976|Bacteroidetes,1IQQQ@117747|Sphingobacteriia	976|Bacteroidetes	P	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,rhaM
k59_338972_1	1286106.MPL1_01672	1.71e-64	212.0	COG1726@1|root,COG1726@2|Bacteria,1MU36@1224|Proteobacteria,1RPU1@1236|Gammaproteobacteria,460CI@72273|Thiotrichales	72273|Thiotrichales	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrA	-	1.6.5.8	ko:K00346	-	-	-	-	ko00000,ko01000	-	-	-	NQRA,NQRA_SLBB
k59_228093_1	1463855.JOHV01000001_gene1697	3.07e-14	76.3	COG1063@1|root,COG1063@2|Bacteria,2GKBE@201174|Actinobacteria	201174|Actinobacteria	E	alcohol dehydrogenase	-	-	1.1.1.1,1.1.1.14	ko:K00001,ko:K00008	ko00010,ko00040,ko00051,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00040,map00051,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	M00014	R00623,R00754,R00875,R01896,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00085,RC00087,RC00088,RC00099,RC00102,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_1007958_1	1121033.AUCF01000001_gene2241	1.41e-96	297.0	COG0143@1|root,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,2TQKA@28211|Alphaproteobacteria,2JPGA@204441|Rhodospirillales	204441|Rhodospirillales	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g
k59_452051_1	926569.ANT_10850	3.57e-57	202.0	COG2203@1|root,COG2770@1|root,COG5002@1|root,COG2203@2|Bacteria,COG2770@2|Bacteria,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	phoR	GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0004721,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016021,GO:0016036,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0016787,GO:0016788,GO:0016791,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0031224,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0035556,GO:0036211,GO:0042578,GO:0042594,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071496,GO:0071704,GO:0071944,GO:0140096,GO:1901564	2.7.13.3	ko:K02484,ko:K07636,ko:K07642	ko02020,map02020	M00434,M00450,M00645,M00646,M00648	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF3329,HATPase_c,HisKA,PAS,PAS_8
k59_396227_1	322710.Avin_18860	2.91e-32	131.0	COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,1RQVZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Dehydrogenase	gdhB	-	1.4.1.2	ko:K15371	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	-	R00243	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	Bac_GDH,GDH_N
k59_452054_1	1509405.GV67_12630	1.29e-38	139.0	COG3181@1|root,COG3181@2|Bacteria,1N3HN@1224|Proteobacteria,2UDSB@28211|Alphaproteobacteria,4BAAR@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_452060_1	1382306.JNIM01000001_gene4224	9.91e-13	74.7	COG0617@1|root,COG0617@2|Bacteria,2G6B7@200795|Chloroflexi	200795|Chloroflexi	J	PFAM Polynucleotide adenylyltransferase region	-	-	2.7.7.19,2.7.7.72	ko:K00970,ko:K00974	ko03013,ko03018,map03013,map03018	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd
k59_187234_1	1459636.NTE_01667	1.91e-50	162.0	arCOG08684@1|root,arCOG08684@2157|Archaea,41T64@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1577415_1	251221.35214602	5.5e-48	174.0	COG0841@1|root,COG0841@2|Bacteria,1G0C2@1117|Cyanobacteria	1117|Cyanobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_1743867_1	882083.SacmaDRAFT_4023	4.26e-21	97.1	COG1028@1|root,COG1028@2|Bacteria,2IB9W@201174|Actinobacteria,4E06S@85010|Pseudonocardiales	201174|Actinobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_631530_1	1120949.KB903294_gene3639	1.43e-39	144.0	arCOG05230@1|root,33GXI@2|Bacteria,2ICB0@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_131451_1	591158.SSMG_03418	7.89e-45	159.0	COG0500@1|root,COG2226@2|Bacteria,2GNXF@201174|Actinobacteria	201174|Actinobacteria	Q	methyltransferase	-	-	2.1.1.288	ko:K15942,ko:K21172	ko01057,ko01059,ko01130,map01057,map01059,map01130	M00781,M00825	R06675,R06680	RC00003,RC00460	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_25
k59_1076989_1	1117379.BABA_16192	3.03e-14	72.4	COG0517@1|root,COG0517@2|Bacteria,1V9ZB@1239|Firmicutes,4ISB2@91061|Bacilli,1ZS4F@1386|Bacillus	91061|Bacilli	S	COG0517 FOG CBS domain	yhcV	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_853750_1	1049564.TevJSym_ax00490	2.79e-45	167.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1J5F8@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_688571_1	926569.ANT_18220	8.09e-72	222.0	COG1143@1|root,COG1143@2|Bacteria,2G6SE@200795|Chloroflexi	200795|Chloroflexi	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.6.5.3	ko:K00338,ko:K03615	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
k59_743794_1	373903.Hore_23470	1.26e-08	55.5	COG1664@1|root,COG1664@2|Bacteria,1VEVU@1239|Firmicutes,24QT5@186801|Clostridia,3WAX3@53433|Halanaerobiales	186801|Clostridia	M	Integral membrane protein CcmA involved in cell shape determination	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
k59_743794_2	498211.CJA_2920	6.82e-19	85.5	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,1RMIR@1236|Gammaproteobacteria,1FGS2@10|Cellvibrio	1236|Gammaproteobacteria	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_576283_1	485915.Dret_1160	1.54e-19	91.3	COG4965@1|root,COG4965@2|Bacteria,1MUXK@1224|Proteobacteria,42QS0@68525|delta/epsilon subdivisions,2WMU6@28221|Deltaproteobacteria,2M8XP@213115|Desulfovibrionales	28221|Deltaproteobacteria	U	PFAM Type II secretion system F	-	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
k59_688580_1	164757.Mjls_0790	8.25e-35	134.0	COG2114@1|root,COG2267@1|root,COG2114@2|Bacteria,COG2267@2|Bacteria,2IASU@201174|Actinobacteria,232Z7@1762|Mycobacteriaceae	201174|Actinobacteria	IT	PFAM Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Guanylate_cyc
k59_911384_1	1128421.JAGA01000003_gene2871	6.08e-97	295.0	COG5557@1|root,COG5557@2|Bacteria,2NNNQ@2323|unclassified Bacteria	2|Bacteria	C	Polysulphide reductase, NrfD	nrfD	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	DUF3341,NrfD
k59_298864_1	470145.BACCOP_00636	2.01e-25	106.0	COG3293@1|root,2ZJP3@2|Bacteria,4NS7F@976|Bacteroidetes,2G058@200643|Bacteroidia,4AWEJ@815|Bacteroidaceae	976|Bacteroidetes	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_4,HTH_Tnp_4
k59_743810_1	1235798.C817_04173	7.98e-05	48.9	COG1309@1|root,COG1309@2|Bacteria,1V8TI@1239|Firmicutes,24F39@186801|Clostridia	186801|Clostridia	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
k59_76301_1	1128421.JAGA01000002_gene232	1.2e-33	134.0	COG4191@1|root,COG4191@2|Bacteria,2NP93@2323|unclassified Bacteria	2|Bacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS_4,PAS_9,Response_reg
k59_1410831_1	935948.KE386493_gene2352	1.48e-09	58.9	COG1160@1|root,COG1160@2|Bacteria,1TPNM@1239|Firmicutes,2493T@186801|Clostridia,42F2X@68295|Thermoanaerobacterales	186801|Clostridia	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
k59_1410831_2	1449357.JQLK01000001_gene2028	2.35e-31	120.0	COG0344@1|root,COG0344@2|Bacteria,1WJ35@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
k59_1022228_1	502025.Hoch_3204	2.05e-110	347.0	COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,42MYQ@68525|delta/epsilon subdivisions,2WJM2@28221|Deltaproteobacteria,2YTST@29|Myxococcales	28221|Deltaproteobacteria	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	2.7.7.7	ko:K02337,ko:K14162	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_76316_1	338963.Pcar_2297	1.18e-36	140.0	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,42RY7@68525|delta/epsilon subdivisions,2WNY9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
k59_576330_1	1254432.SCE1572_10345	7.06e-36	140.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,2YXGU@29|Myxococcales	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_21038_1	671143.DAMO_1166	1.97e-10	60.1	COG1622@1|root,COG1622@2|Bacteria,2NNSH@2323|unclassified Bacteria	2|Bacteria	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	coxM	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009319,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034641,GO:0042773,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0055086,GO:0055114,GO:0070069,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrom_C
k59_21038_2	398525.KB900701_gene1252	5.96e-22	97.1	COG4638@1|root,COG4638@2|Bacteria,1MX47@1224|Proteobacteria,2TV03@28211|Alphaproteobacteria,3JTQC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Rieske [2Fe-2S] domain	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
k59_466503_1	36331.EPrPI00000015596	3.33e-14	79.7	COG0657@1|root,KOG1515@2759|Eukaryota	2759|Eukaryota	I	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,Peptidase_S9
k59_187305_1	1121106.JQKB01000120_gene3958	5.6e-21	87.8	COG3293@1|root,COG3293@2|Bacteria,1PVIT@1224|Proteobacteria,2TURP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
k59_187305_2	272568.GDI2986	3.05e-53	172.0	COG3293@1|root,COG3293@2|Bacteria,1RFRK@1224|Proteobacteria,2U8TH@28211|Alphaproteobacteria,2JTJP@204441|Rhodospirillales	204441|Rhodospirillales	L	Putative transposase of IS4/5 family (DUF4096)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4096
k59_131539_1	1203554.HMPREF1476_00876	0.000267	46.6	COG1042@1|root,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2VI9R@28216|Betaproteobacteria,4PQU3@995019|Sutterellaceae	28216|Betaproteobacteria	C	CoA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,Acetyltransf_4,CoA_binding_2,Succ_CoA_lig
k59_1410878_1	234267.Acid_7393	7.28e-27	113.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria	57723|Acidobacteria	KLTU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
k59_1022269_1	644282.Deba_0344	1.34e-30	121.0	COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,42NYT@68525|delta/epsilon subdivisions,2WIM3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
k59_1022269_2	370438.PTH_1585	2.74e-07	53.9	COG1640@1|root,COG1640@2|Bacteria,1W5VQ@1239|Firmicutes,25E46@186801|Clostridia,2610T@186807|Peptococcaceae	186801|Clostridia	G	PFAM glycoside hydrolase family 77	malQ	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
k59_187322_1	83406.HDN1F_30400	4.25e-87	277.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,1J7SB@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	3-hydroxyacyl-coa dehydrogenase	fadJ	-	1.1.1.35,4.2.1.17,5.1.2.3	ko:K01782	ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
k59_1245766_1	575540.Isop_2303	9.42e-13	74.7	COG0265@1|root,COG2234@1|root,COG0265@2|Bacteria,COG2234@2|Bacteria,2IX8E@203682|Planctomycetes	203682|Planctomycetes	O	PA domain	-	-	-	-	-	-	-	-	-	-	-	-	PA,PD40,PDZ_2,Peptidase_M28
k59_1466524_1	314260.PB2503_00410	2.55e-53	174.0	COG0309@1|root,COG0309@2|Bacteria,1QYQA@1224|Proteobacteria,2TXVP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_2
k59_1688811_1	1380394.JADL01000009_gene3286	1.71e-106	332.0	COG5426@1|root,COG5426@2|Bacteria,1MVWA@1224|Proteobacteria,2TQNQ@28211|Alphaproteobacteria,2JQ89@204441|Rhodospirillales	204441|Rhodospirillales	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_743888_1	864702.OsccyDRAFT_4062	8.06e-31	115.0	COG1611@1|root,COG1611@2|Bacteria,1GC1H@1117|Cyanobacteria,1HFBA@1150|Oscillatoriales	1117|Cyanobacteria	S	Possible lysine decarboxylase	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
k59_576385_1	743718.Isova_2482	1.8e-73	239.0	COG3387@1|root,COG3387@2|Bacteria,2GJAD@201174|Actinobacteria,4F3PP@85017|Promicromonosporaceae	201174|Actinobacteria	G	Glycosyl hydrolases family 15	-	GO:0003674,GO:0003824,GO:0004553,GO:0004555,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005984,GO:0005991,GO:0005993,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009987,GO:0015927,GO:0016020,GO:0016052,GO:0016787,GO:0016798,GO:0042301,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044464,GO:0046352,GO:0071704,GO:0071944,GO:1901575	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_15
k59_466554_1	225937.HP15_1281	8.18e-30	119.0	COG2035@1|root,COG2035@2|Bacteria,1MXVI@1224|Proteobacteria,1RN4B@1236|Gammaproteobacteria,466EX@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Domain of unknown function (DUF368)	-	-	-	ko:K08974	-	-	-	-	ko00000	-	-	-	DUF368
k59_466554_2	269800.Tfu_2582	1.77e-14	70.9	COG2197@1|root,COG2197@2|Bacteria,2GIVA@201174|Actinobacteria,4EHIU@85012|Streptosporangiales	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	tcsR3	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_1410905_2	1395587.P364_0109300	4.67e-17	79.3	COG0500@1|root,COG2226@2|Bacteria,1UIRD@1239|Firmicutes,4HIXX@91061|Bacilli,274IF@186822|Paenibacillaceae	91061|Bacilli	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_521427_1	1123242.JH636435_gene2578	7.22e-17	85.9	COG0210@1|root,COG0210@2|Bacteria,2IWT0@203682|Planctomycetes	203682|Planctomycetes	L	COG0210 Superfamily I DNA and RNA	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_1299614_1	1121378.KB899708_gene1165	1.58e-07	55.1	COG1574@1|root,COG1574@2|Bacteria,1WI3B@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	COGs COG1574 metal-dependent hydrolase with the TIM-barrel fold	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_131593_1	2340.JV46_27880	2.07e-221	617.0	COG2801@1|root,COG2801@2|Bacteria,1N207@1224|Proteobacteria,1S1FB@1236|Gammaproteobacteria,1J9CZ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	leucine-zipper of insertion element IS481	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_32,LZ_Tnp_IS481,rve,rve_3
k59_1410926_1	596152.DesU5LDRAFT_3244	1.71e-44	158.0	COG0436@1|root,COG0436@2|Bacteria,1MX43@1224|Proteobacteria,42Q5H@68525|delta/epsilon subdivisions,2WKW4@28221|Deltaproteobacteria,2M80H@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Aminotransferase, class I	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
k59_131601_1	388399.SSE37_03680	1.46e-06	55.5	COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2TRC2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Acetyl propionyl-CoA carboxylase alpha subunit	mccA	-	6.4.1.4	ko:K01968	ko00280,ko01100,map00280,map01100	M00036	R04138	RC00367,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
k59_466578_2	1380394.JADL01000003_gene5081	1.04e-56	195.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,2JR1T@204441|Rhodospirillales	204441|Rhodospirillales	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,TPR_19
k59_799499_1	1501230.ET33_13240	4.36e-60	195.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	2.7.1.83	ko:K16328	ko00240,map00240	-	R03315	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25
k59_1577587_1	263358.VAB18032_28891	8.92e-30	119.0	COG0624@1|root,COG0624@2|Bacteria,2GM84@201174|Actinobacteria,4D8NU@85008|Micromonosporales	201174|Actinobacteria	E	Peptidase dimerisation domain	argE	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
k59_1577587_2	42565.FP66_02095	5.8e-07	49.7	COG0219@1|root,COG0219@2|Bacteria,1RCY4@1224|Proteobacteria,1S3PI@1236|Gammaproteobacteria,1XJKM@135619|Oceanospirillales	135619|Oceanospirillales	J	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide	trmL	-	2.1.1.207	ko:K03216	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
k59_1188447_1	1173028.ANKO01000127_gene4150	4e-39	144.0	COG1972@1|root,COG1972@2|Bacteria,1G3CA@1117|Cyanobacteria,1H7FT@1150|Oscillatoriales	1117|Cyanobacteria	F	PFAM Na dependent nucleoside transporter	-	-	-	ko:K03317	-	-	-	-	ko00000	2.A.41	-	-	Gate,Nucleos_tra2_C,Nucleos_tra2_N
k59_1577596_1	596153.Alide_1018	4.23e-08	53.9	COG3292@1|root,COG3292@2|Bacteria,1QMJ4@1224|Proteobacteria,2VNHI@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Two component regulator propeller	-	-	-	-	-	-	-	-	-	-	-	-	Tail_P2_I
k59_1577596_2	1123392.AQWL01000008_gene1237	4.37e-38	147.0	COG3299@1|root,COG3299@2|Bacteria,1P3E0@1224|Proteobacteria,2VKDQ@28216|Betaproteobacteria	28216|Betaproteobacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	Baseplate_J,PA14
k59_1744039_1	1280950.HJO_13876	2.27e-32	116.0	COG0295@1|root,COG0295@2|Bacteria,1MY2R@1224|Proteobacteria,2U9FW@28211|Alphaproteobacteria,44099@69657|Hyphomonadaceae	28211|Alphaproteobacteria	F	This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis	cdd	-	3.5.4.5	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1,dCMP_cyt_deam_2
k59_1744039_2	349521.HCH_02312	4.81e-38	135.0	COG1079@1|root,COG1079@2|Bacteria,1MVDQ@1224|Proteobacteria,1RR75@1236|Gammaproteobacteria,1XH8B@135619|Oceanospirillales	135619|Oceanospirillales	P	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
k59_1355492_1	760117.JN27_16260	7.7e-18	82.8	COG2928@1|root,COG2928@2|Bacteria,1MWT5@1224|Proteobacteria,2VH65@28216|Betaproteobacteria,4761R@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF502)	-	-	-	-	-	-	-	-	-	-	-	-	DUF502
k59_1466623_1	1397527.Q670_06010	2.43e-07	60.5	COG3386@1|root,COG3386@2|Bacteria,1R8NE@1224|Proteobacteria,1S1N9@1236|Gammaproteobacteria,1XNUM@135619|Oceanospirillales	135619|Oceanospirillales	G	Protein of unknown function (DUF1573)	-	-	-	-	-	-	-	-	-	-	-	-	ASH
k59_21166_1	1177928.TH2_04433	0.000787	40.8	COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,2TT0D@28211|Alphaproteobacteria,2JPG8@204441|Rhodospirillales	204441|Rhodospirillales	E	Threonine synthase	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_synth_N
k59_1357415_1	644966.Tmar_0464	3.91e-80	249.0	COG1494@1|root,COG1494@2|Bacteria,1TP0D@1239|Firmicutes,249PW@186801|Clostridia,3WCSA@538999|Clostridiales incertae sedis	186801|Clostridia	G	Bacterial fructose-1,6-bisphosphatase, glpX-encoded	glpX	-	3.1.3.11	ko:K02446	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00165,M00167	R00762,R04780	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_glpX
k59_1247804_1	479434.Sthe_1718	1.98e-19	90.5	COG1560@1|root,COG1560@2|Bacteria,2G7BA@200795|Chloroflexi,27Y7M@189775|Thermomicrobia	189775|Thermomicrobia	M	Bacterial lipid A biosynthesis acyltransferase	-	-	2.3.1.241,2.3.1.265	ko:K02517,ko:K22311	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
k59_1190526_2	1519464.HY22_14410	1.47e-89	281.0	COG1249@1|root,COG1249@2|Bacteria,1FDB4@1090|Chlorobi	1090|Chlorobi	C	pyridine nucleotide-disulphide oxidoreductase dimerisation region	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_1190530_1	570967.JMLV01000009_gene1085	2.67e-74	235.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,2JQKF@204441|Rhodospirillales	204441|Rhodospirillales	C	III protein, CoA-transferase family	-	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
k59_301000_1	1541065.JRFE01000010_gene4297	1.68e-84	279.0	COG3540@1|root,COG4222@1|root,COG4247@1|root,COG3540@2|Bacteria,COG4222@2|Bacteria,COG4247@2|Bacteria,1G00S@1117|Cyanobacteria	1117|Cyanobacteria	C	PFAM Phytase	-	-	3.1.3.1,3.1.3.8,3.1.4.46	ko:K01083,ko:K01113,ko:K01126	ko00562,ko00564,ko00790,ko01100,ko02020,map00562,map00564,map00790,map01100,map02020	M00126	R01030,R01470,R03371,R04620	RC00017,RC00078,RC00425	ko00000,ko00001,ko00002,ko01000	-	-	-	Calx-beta,DUF4114,Exo_endo_phos,GDPD,HemolysinCabind,PhoD,PhoD_N,Phytase,Phytase-like,SurE
k59_1357434_1	56107.Cylst_1736	4.96e-69	224.0	COG0076@1|root,COG0076@2|Bacteria,1G3F8@1117|Cyanobacteria,1HP30@1161|Nostocales	1117|Cyanobacteria	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	4.1.1.105,4.1.1.15,4.1.1.28,4.1.1.86	ko:K01580,ko:K01593,ko:K13745	ko00250,ko00260,ko00350,ko00360,ko00380,ko00410,ko00430,ko00650,ko00901,ko00950,ko00965,ko01100,ko01110,ko01120,ko02024,ko04726,ko04727,ko04728,ko04940,ko05030,ko05031,ko05034,map00250,map00260,map00350,map00360,map00380,map00410,map00430,map00650,map00901,map00950,map00965,map01100,map01110,map01120,map02024,map04726,map04727,map04728,map04940,map05030,map05031,map05034	M00027,M00037,M00042	R00261,R00489,R00685,R00699,R00736,R01682,R02080,R02466,R02701,R04909,R07650	RC00299	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyridoxal_deC
k59_412121_1	575540.Isop_1192	1.07e-28	117.0	COG2204@1|root,COG2204@2|Bacteria,2IXMN@203682|Planctomycetes	203682|Planctomycetes	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	-	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_412121_2	911239.CF149_08292	2.99e-05	47.4	COG4251@1|root,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,1RYEF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Histidine kinase	bphP	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS_2,PHY,Response_reg
k59_23107_1	443143.GM18_2644	3e-22	101.0	COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,42PWS@68525|delta/epsilon subdivisions,2WKI5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	TonB-dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TPR_8,TonB_dep_Rec
k59_245098_1	1144310.PMI07_001928	3.97e-97	290.0	COG0329@1|root,COG0329@2|Bacteria	2|Bacteria	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
k59_1079128_1	326427.Cagg_1770	2e-15	81.6	COG1572@1|root,COG1572@2|Bacteria,2GAID@200795|Chloroflexi,376C4@32061|Chloroflexia	32061|Chloroflexia	NU	bacterial-type flagellum-dependent cell motility	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1301650_1	1234595.C725_1405	2.7e-87	282.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,2TT3T@28211|Alphaproteobacteria,4BPGQ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	acnA	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0045333,GO:0046459,GO:0047456,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:1901363	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k59_1135401_1	574966.KB898646_gene3345	1.24e-102	308.0	COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,1RMEC@1236|Gammaproteobacteria,1XHA8@135619|Oceanospirillales	135619|Oceanospirillales	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
k59_1524045_1	398767.Glov_3502	1.26e-71	228.0	COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,42N2A@68525|delta/epsilon subdivisions,2WIP6@28221|Deltaproteobacteria,43TMJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
k59_913654_1	1121015.N789_13770	2.5e-68	225.0	COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,1RMWS@1236|Gammaproteobacteria,1X3IH@135614|Xanthomonadales	135614|Xanthomonadales	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
k59_759468_1	670487.Ocepr_1613	1.28e-13	67.8	COG0097@1|root,COG0097@2|Bacteria,1WJXT@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
k59_759468_2	203119.Cthe_2919	8.64e-39	133.0	COG0256@1|root,COG0256@2|Bacteria,1V6DM@1239|Firmicutes,24JCS@186801|Clostridia,3WJ8R@541000|Ruminococcaceae	186801|Clostridia	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	-	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
k59_1483235_1	1173027.Mic7113_5799	6.9e-47	154.0	COG3339@1|root,COG3339@2|Bacteria,1G7DF@1117|Cyanobacteria,1HFS6@1150|Oscillatoriales	1117|Cyanobacteria	S	Protein of unknown function (DUF1232)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1232
k59_1594259_1	1284352.AOIG01000010_gene1975	7.64e-07	56.6	COG0515@1|root,COG2199@1|root,COG2203@1|root,COG3899@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG3706@2|Bacteria,COG3899@2|Bacteria,1UI4Q@1239|Firmicutes,4HP00@91061|Bacilli,274BV@186822|Paenibacillaceae	91061|Bacilli	KLT	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GAF,GGDEF,PAS_8,PAS_9,Pkinase
k59_370292_1	323261.Noc_1755	6.85e-05	44.7	COG0673@1|root,COG0673@2|Bacteria,1MV7C@1224|Proteobacteria,1SYTB@1236|Gammaproteobacteria,1WWFT@135613|Chromatiales	135613|Chromatiales	S	PFAM oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
k59_370292_2	1009370.ALO_15682	1.89e-44	154.0	COG3494@1|root,COG3494@2|Bacteria,1U1G6@1239|Firmicutes,4H2CZ@909932|Negativicutes	909932|Negativicutes	S	Psort location Cytoplasmic, score 8.96	-	-	-	ko:K09949	-	-	-	-	ko00000	-	-	-	DUF1009
k59_1706750_1	1121887.AUDK01000024_gene1091	4.44e-08	53.9	COG1472@1|root,COG1472@2|Bacteria,4NE90@976|Bacteroidetes,1HX27@117743|Flavobacteriia,2NSID@237|Flavobacterium	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 3 family	bglX	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
k59_1706750_2	391587.KAOT1_04115	4.71e-76	243.0	COG3119@1|root,COG3119@2|Bacteria,4NHH7@976|Bacteroidetes,1HX4R@117743|Flavobacteriia	976|Bacteroidetes	P	arylsulfatase a	atsA_1	-	-	ko:K01138	-	-	-	-	ko00000,ko01000	-	-	-	DUF4976,Sulfatase
k59_1537439_1	1121441.AUCX01000021_gene703	1.82e-37	145.0	COG2984@1|root,COG5002@1|root,COG2984@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,42NK9@68525|delta/epsilon subdivisions,2WMCQ@28221|Deltaproteobacteria,2MH9G@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	ABC_sub_bind,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
k59_1204421_1	903818.KI912269_gene16	1.09e-05	52.8	COG0318@1|root,COG0318@2|Bacteria	2|Bacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
k59_1093841_1	1057002.KB905370_gene3672	7e-67	230.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2TRWM@28211|Alphaproteobacteria,4BB6Z@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	cation efflux system protein (Heavy metal efflux pump)	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_870270_1	608538.HTH_1716	6.93e-130	377.0	COG1140@1|root,COG1140@2|Bacteria,2G4XI@200783|Aquificae	200783|Aquificae	C	4Fe-4S dicluster domain	-	-	1.7.5.1	ko:K00371,ko:K17051	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000,ko02000	5.A.3.1,5.A.3.8	-	-	Fer4_11
k59_1537456_1	177437.HRM2_p00180	5.95e-63	209.0	COG4584@1|root,COG4584@2|Bacteria	2|Bacteria	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	HTH_38,HTH_7,rve
k59_1204430_2	1121904.ARBP01000011_gene1456	3.11e-41	146.0	COG0668@1|root,COG0668@2|Bacteria,4NMNE@976|Bacteroidetes,47XHW@768503|Cytophagia	976|Bacteroidetes	M	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
k59_983924_1	861299.J421_2767	2.89e-85	283.0	COG0085@1|root,COG0085@2|Bacteria,1ZSQH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_426072_1	1117958.PE143B_0130865	1.29e-72	233.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,1RQVT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	COG3666 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_1262289_1	671143.DAMO_3156	2.24e-47	169.0	COG1538@1|root,COG1538@2|Bacteria,2NP5D@2323|unclassified Bacteria	2|Bacteria	MU	Outer membrane efflux protein	tolC	-	-	ko:K12340	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	1.B.17,2.A.6.2	-	-	OEP
k59_1262304_1	391625.PPSIR1_08911	1.16e-46	152.0	COG1145@1|root,COG1145@2|Bacteria,1MZ6H@1224|Proteobacteria,42U8W@68525|delta/epsilon subdivisions,2X3DV@28221|Deltaproteobacteria,2YVMF@29|Myxococcales	28221|Deltaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_7
k59_705251_1	1205680.CAKO01000010_gene3897	1.72e-27	112.0	COG2141@1|root,COG2141@2|Bacteria,1MUTJ@1224|Proteobacteria,2TTZI@28211|Alphaproteobacteria,2JXQN@204441|Rhodospirillales	204441|Rhodospirillales	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_370381_1	443144.GM21_2798	4.46e-138	414.0	COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,42MDI@68525|delta/epsilon subdivisions,2WIVY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	malic protein domain protein	maeB	-	1.1.1.40	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00169,M00172	R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1637	Malic_M,PTA_PTB,malic
k59_316291_1	1121946.AUAX01000028_gene5814	1.8e-137	399.0	COG2873@1|root,COG2873@2|Bacteria,2I2EB@201174|Actinobacteria,4DMJF@85008|Micromonosporales	201174|Actinobacteria	E	Cys/Met metabolism PLP-dependent enzyme	cysD	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
k59_484060_1	546271.Selsp_1734	2.34e-16	82.4	COG1566@1|root,COG1566@2|Bacteria,1UJ4C@1239|Firmicutes,4H2H7@909932|Negativicutes	909932|Negativicutes	V	Secretion protein	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_D23
k59_1372045_1	1089547.KB913013_gene326	2.17e-32	118.0	COG2391@1|root,COG2391@2|Bacteria,4NQ9C@976|Bacteroidetes,47P92@768503|Cytophagia	976|Bacteroidetes	S	PFAM YeeE YedE family (DUF395)	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
k59_1372045_2	649638.Trad_0802	4.83e-19	82.4	COG2391@1|root,COG2391@2|Bacteria,1WK5Y@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM YeeE YedE family (DUF395)	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
k59_1537502_2	323848.Nmul_A0212	4.21e-92	283.0	COG0403@1|root,COG0403@2|Bacteria,1MVC1@1224|Proteobacteria,2VKQB@28216|Betaproteobacteria,3720Y@32003|Nitrosomonadales	28216|Betaproteobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
k59_592410_1	861299.J421_0588	1.53e-57	202.0	COG4447@1|root,COG4447@2|Bacteria,1ZSRH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Sortilin, neurotensin receptor 3,	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
k59_705276_1	379066.GAU_1738	9.55e-79	249.0	COG0034@1|root,COG0034@2|Bacteria,1ZTD7@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6
k59_36442_1	1379270.AUXF01000007_gene885	6.2e-43	153.0	COG3202@1|root,COG3202@2|Bacteria,1ZURB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	TLC ATP/ADP transporter	-	-	-	ko:K03301	-	-	-	-	ko00000	2.A.12	-	-	TLC
k59_426111_2	633131.TR2A62_3544	0.000453	43.5	2EP1H@1|root,33GNC@2|Bacteria,1R18Z@1224|Proteobacteria,2TYYS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_2
k59_147328_1	247490.KSU1_C1691	3.55e-57	186.0	COG0602@1|root,COG0602@2|Bacteria,2IYXV@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	-	4.3.99.3	ko:K10026	ko00790,ko01100,map00790,map01100	-	R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	-	Fer4_14,Radical_SAM
k59_1093928_1	42256.RradSPS_1475	8.92e-20	88.2	COG0242@1|root,COG0242@2|Bacteria,2GJ87@201174|Actinobacteria,4CQ1V@84995|Rubrobacteria	84995|Rubrobacteria	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
k59_147345_1	709797.CSIRO_1877	6.38e-41	142.0	COG0625@1|root,COG0625@2|Bacteria,1N2Z1@1224|Proteobacteria,2U0AX@28211|Alphaproteobacteria,3JQT5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Glutathione S-transferase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	GST_C_2,GST_N
k59_1149984_1	926569.ANT_02250	1.07e-71	234.0	COG0532@1|root,COG0532@2|Bacteria,2G5UR@200795|Chloroflexi	200795|Chloroflexi	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
k59_92436_2	526227.Mesil_0100	5.8e-37	129.0	COG2905@1|root,COG2905@2|Bacteria,1WJV4@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	signal-transduction protein containing cAMP-binding and CBS domains	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_1594406_1	1278073.MYSTI_07864	7.84e-38	146.0	COG0577@1|root,COG0577@2|Bacteria,1NREW@1224|Proteobacteria	1224|Proteobacteria	V	COG0577 ABC-type antimicrobial peptide transport system permease component	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_984002_1	383372.Rcas_0129	1.06e-14	79.0	COG0531@1|root,COG0531@2|Bacteria,2G76Z@200795|Chloroflexi	200795|Chloroflexi	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease,AA_permease_2
k59_92444_1	765914.ThisiDRAFT_0340	7.62e-26	104.0	COG0237@1|root,COG0237@2|Bacteria,1RCXT@1224|Proteobacteria,1S3NR@1236|Gammaproteobacteria,1WY99@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	-	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE
k59_370442_1	1095743.HMPREF1054_0045	5.91e-27	108.0	COG0565@1|root,COG0565@2|Bacteria,1N47Y@1224|Proteobacteria,1RPD3@1236|Gammaproteobacteria,1Y6ZE@135625|Pasteurellales	135625|Pasteurellales	J	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA	trmJ	-	2.1.1.200	ko:K15396	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
k59_646915_1	493475.GARC_2156	1.26e-12	75.9	COG2885@1|root,COG2885@2|Bacteria,1QW22@1224|Proteobacteria,1T4AK@1236|Gammaproteobacteria,46ACU@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,OmpA
k59_202534_1	264198.Reut_C6311	2.37e-40	144.0	COG0715@1|root,COG0715@2|Bacteria,1NS24@1224|Proteobacteria	1224|Proteobacteria	P	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components	-	-	-	-	-	-	-	-	-	-	-	-	NMT1_2
k59_537473_1	1120985.AUMI01000014_gene733	7.44e-05	49.7	COG0356@1|root,COG0356@2|Bacteria,1TQIT@1239|Firmicutes,4H33W@909932|Negativicutes	909932|Negativicutes	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
k59_1372111_2	1125971.ASJB01000099_gene2461	3.39e-42	154.0	COG4805@1|root,COG4805@2|Bacteria,2GMUR@201174|Actinobacteria,4DZQU@85010|Pseudonocardiales	201174|Actinobacteria	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
k59_202540_1	1037409.BJ6T_48030	1.08e-39	142.0	COG1878@1|root,COG1878@2|Bacteria,1Q49R@1224|Proteobacteria,2UI8Z@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
k59_1483409_1	497964.CfE428DRAFT_5282	2.81e-84	260.0	COG0562@1|root,COG0562@2|Bacteria,46SKA@74201|Verrucomicrobia	74201|Verrucomicrobia	M	UDP-galactopyranose mutase	-	-	5.4.99.9	ko:K01854	ko00052,ko00520,map00052,map00520	-	R00505,R09009	RC00317,RC02396	ko00000,ko00001,ko01000	-	-	-	GLF,NAD_binding_8
k59_1040319_1	1280944.HY17_19430	3.53e-17	86.3	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,43Z60@69657|Hyphomonadaceae	28211|Alphaproteobacteria	L	Transposase	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1093967_1	1219035.NT2_09_00160	2.73e-07	55.1	COG1028@1|root,COG1028@2|Bacteria,1R413@1224|Proteobacteria,2TW0W@28211|Alphaproteobacteria,2KDTR@204457|Sphingomonadales	204457|Sphingomonadales	IQ	Short-chain dehydrogenase reductase sdr	-	-	-	ko:K15237	ko00361,ko01100,ko01120,map00361,map01100,map01120	-	R05243	RC01305	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
k59_1093969_1	65393.PCC7424_4132	1.31e-87	274.0	COG0033@1|root,COG0033@2|Bacteria,1G4TU@1117|Cyanobacteria,3KJFW@43988|Cyanothece	1117|Cyanobacteria	G	phosphoglucomutase phosphomannomutase alpha beta alpha domain I	-	-	5.4.2.2	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00549	R00959,R01057,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	iJN678.pgm	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_816717_2	1121352.JHZP01000001_gene301	8.29e-19	85.5	COG1778@1|root,COG1778@2|Bacteria,1RH85@1224|Proteobacteria,2VRQX@28216|Betaproteobacteria,2KR4K@206351|Neisseriales	206351|Neisseriales	S	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family	kdsC	-	3.1.3.45	ko:K03270	ko00540,ko01100,map00540,map01100	M00063	R03350	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase,Hydrolase_3
k59_1095298_1	1120972.AUMH01000002_gene2762	2.67e-25	108.0	COG4819@1|root,COG4819@2|Bacteria,1TQ6T@1239|Firmicutes,4HAEM@91061|Bacilli	91061|Bacilli	E	ethanolamine utilization protein	eutA	-	-	ko:K04019	ko00564,ko01100,map00564,map01100	-	R00749	RC00370	ko00000,ko00001	-	-	-	EutA
k59_930870_1	1274524.BSONL12_11741	3.1e-14	76.6	COG0022@1|root,COG0022@2|Bacteria,1TP3J@1239|Firmicutes,4HA4H@91061|Bacilli,1ZBJ1@1386|Bacillus	91061|Bacilli	C	COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit	pdhB	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS05355,iYO844.BSU14590	Transket_pyr,Transketolase_C
k59_427490_1	234267.Acid_7702	7.74e-82	254.0	COG0520@1|root,COG0520@2|Bacteria,3Y2SC@57723|Acidobacteria	57723|Acidobacteria	E	Aminotransferase class-V	-	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
k59_871767_1	34506.g2333	1.58e-24	103.0	COG0582@1|root,2S871@2759|Eukaryota,3AK9M@33154|Opisthokonta,3C03N@33208|Metazoa,3DG8M@33213|Bilateria,40PKU@6231|Nematoda,1M73W@119089|Chromadorea,415PP@6236|Rhabditida	33208|Metazoa	L	Arm DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Arm-DNA-bind_3,Phage_integrase
k59_259814_1	1379270.AUXF01000007_gene888	1.65e-73	235.0	COG2355@1|root,COG2355@2|Bacteria,1ZT5A@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Membrane dipeptidase (Peptidase family M19)	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
k59_985324_1	485913.Krac_10888	2.02e-05	50.8	COG3385@1|root,COG3385@2|Bacteria,2G7KG@200795|Chloroflexi	200795|Chloroflexi	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_1041643_1	1192034.CAP_7451	1.09e-16	84.7	COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,42MCE@68525|delta/epsilon subdivisions,2WIYP@28221|Deltaproteobacteria,2YYXE@29|Myxococcales	28221|Deltaproteobacteria	M	Glycosyltransferase like family 2	-	-	2.4.2.53	ko:K10012	ko00520,ko01503,map00520,map01503	M00721,M00761	R07661	RC00005,RC02954	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	4.D.2.1.8	GT2	-	Glycos_transf_2
k59_1595816_1	1121472.AQWN01000007_gene1129	1.31e-08	57.0	COG1071@1|root,COG1071@2|Bacteria,1TQDG@1239|Firmicutes,249HX@186801|Clostridia,2602A@186807|Peptococcaceae	186801|Clostridia	C	Dehydrogenase E1 component	pdhA	-	-	ko:K21416	-	-	-	-	ko00000,ko01000	-	-	-	E1_dh
k59_1595816_2	330214.NIDE2694	1.45e-46	156.0	COG2148@1|root,COG2148@2|Bacteria	2|Bacteria	M	undecaprenyl-phosphate glucose phosphotransferase activity	pglC	GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006464,GO:0006486,GO:0006487,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0018193,GO:0018196,GO:0018279,GO:0019538,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0070085,GO:0071704,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.7.8.36	ko:K15915,ko:K19428	-	-	R10184	RC00002	ko00000,ko01000	-	-	-	Bac_transf
k59_930906_1	706587.Desti_3549	2.05e-17	82.8	COG0421@1|root,COG0421@2|Bacteria,1P220@1224|Proteobacteria,42NG6@68525|delta/epsilon subdivisions,2WIRU@28221|Deltaproteobacteria,2MQH9@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_93944_2	883.DvMF_2738	6.54e-57	195.0	COG4962@1|root,COG4962@2|Bacteria,1R7EN@1224|Proteobacteria,42NAK@68525|delta/epsilon subdivisions,2WIYX@28221|Deltaproteobacteria,2M8UJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	U	PFAM Type II secretion system protein E	-	-	-	ko:K02283,ko:K03609	-	-	-	-	ko00000,ko02035,ko02044,ko03036,ko04812	-	-	-	CbiA,FHA,T2SSE
k59_1538805_1	317025.Tcr_1066	2.67e-74	236.0	COG0531@1|root,COG0531@2|Bacteria,1QXK2@1224|Proteobacteria,1S18B@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	amino acid	-	-	-	ko:K07076	-	-	-	-	ko00000	-	-	-	AA_permease_2
k59_317795_1	1071085.KK033114_gene736	2.13e-41	144.0	arCOG08934@1|root,arCOG08934@2157|Archaea,2XXBA@28890|Euryarchaeota	28890|Euryarchaeota	Q	carboxymuconolactone decarboxylase	-	-	-	-	-	-	-	-	-	-	-	-	CMD
k59_1760273_1	314287.GB2207_04244	4.37e-35	133.0	COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,1SK3R@1236|Gammaproteobacteria,1JC0T@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Reductase C-terminal	-	-	1.18.1.3,1.7.1.15	ko:K00362,ko:K00529	ko00071,ko00360,ko00910,ko01120,ko01220,map00071,map00360,map00910,map01120,map01220	M00530,M00545	R00787,R02000,R06782,R06783	RC00098,RC00176	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2,Reductase_C
k59_1538812_1	1379698.RBG1_1C00001G0508	1.67e-57	191.0	COG0183@1|root,COG0183@2|Bacteria,2NNU9@2323|unclassified Bacteria	2|Bacteria	I	Belongs to the thiolase family	bktB	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K07508	ko00062,ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00062,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00085,M00087,M00088,M00095,M00373,M00374,M00375	R00238,R00391,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747	RC00004,RC00326,RC00405,RC01702	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_1484809_1	1122197.ATWI01000011_gene293	4.11e-15	73.6	COG2022@1|root,COG2022@2|Bacteria,1N0N5@1224|Proteobacteria,1RMPD@1236|Gammaproteobacteria,465GP@72275|Alteromonadaceae	1236|Gammaproteobacteria	H	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S	thiG	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.8.1.10	ko:K03149	ko00730,ko01100,map00730,map01100	-	R10247	RC03096,RC03097,RC03461	ko00000,ko00001,ko01000	-	-	iECABU_c1320.ECABU_c45060,iECO26_1355.ECO26_5099,ic_1306.c4947	ThiG
k59_1484809_2	3067.XP_002948683.1	8.2e-24	103.0	COG0351@1|root,KOG2598@2759|Eukaryota,37JH3@33090|Viridiplantae,34H6W@3041|Chlorophyta	3041|Chlorophyta	HK	Thiamine monophosphate synthase	-	-	2.5.1.3,2.7.1.49,2.7.4.7	ko:K14153	ko00730,ko01100,map00730,map01100	M00127	R03223,R03471,R04509,R10712	RC00002,RC00017,RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	Phos_pyr_kin,TENA_THI-4,TMP-TENI
k59_203866_1	324602.Caur_3727	3.28e-64	222.0	COG0567@1|root,COG0567@2|Bacteria,2G638@200795|Chloroflexi,3763K@32061|Chloroflexia	32061|Chloroflexia	C	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3)	-	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
k59_706878_1	1304880.JAGB01000002_gene2099	5.87e-35	137.0	COG0507@1|root,COG0507@2|Bacteria,1TPZH@1239|Firmicutes,247R7@186801|Clostridia	186801|Clostridia	L	DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity	recD2	-	3.1.11.5	ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_30,HHH_4,HHH_5,UvrD_C_2
k59_1484820_2	1197906.CAJQ02000006_gene2919	8.55e-31	114.0	2C5R9@1|root,32VFY@2|Bacteria,1N0MI@1224|Proteobacteria,2UDWW@28211|Alphaproteobacteria,3K4DI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1318860_1	472759.Nhal_3516	0.000346	40.0	2EGMT@1|root,33ADY@2|Bacteria,1NH3I@1224|Proteobacteria,1SGAI@1236|Gammaproteobacteria,1WZTM@135613|Chromatiales	135613|Chromatiales	S	Phospholipase_D-nuclease N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_N
k59_1263986_1	379066.GAU_1902	4.55e-53	178.0	COG0536@1|root,COG0536@2|Bacteria,1ZSVS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GTP1_OBG,MMR_HSR1
k59_1760306_2	1334046.AYTB01000017_gene1270	6.98e-34	125.0	COG2071@1|root,COG2071@2|Bacteria,1V1KC@1239|Firmicutes,4HI59@91061|Bacilli,26DEC@186818|Planococcaceae	91061|Bacilli	S	Peptidase C26	-	-	-	ko:K07010	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_C26
k59_1648904_1	1267534.KB906754_gene3162	1.31e-28	119.0	COG0577@1|root,COG0577@2|Bacteria,3Y6DE@57723|Acidobacteria,2JM90@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_1041698_1	1403948.Q618_VCMC00001G0636	1.17e-10	64.3	COG1595@1|root,COG1595@2|Bacteria,2GJ02@201174|Actinobacteria,4D431@85005|Actinomycetales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	sigH	GO:0000988,GO:0000990,GO:0003674,GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016987,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0043254,GO:0044087,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051409,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2000142,GO:2001141	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_946107_2	1173027.Mic7113_4070	2.43e-28	110.0	COG4106@1|root,COG4106@2|Bacteria,1G3BF@1117|Cyanobacteria,1H9QD@1150|Oscillatoriales	1117|Cyanobacteria	S	Methyltransferase domain	-	-	2.1.1.144	ko:K00598	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31
k59_1557640_1	321327.CYA_2283	5.68e-31	120.0	COG1218@1|root,COG1218@2|Bacteria,1G1Z4@1117|Cyanobacteria,1H3WR@1129|Synechococcus	1117|Cyanobacteria	P	Inositol monophosphatase family	-	-	3.1.3.7	ko:K01082	ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	Inositol_P
k59_1668830_1	1122132.AQYH01000005_gene558	1.15e-74	240.0	COG5002@1|root,COG5002@2|Bacteria,1QU7C@1224|Proteobacteria,2TWBW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	signal transduction histidine kinase	chvG	-	2.7.13.3	ko:K14980	ko02020,map02020	M00520	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,Sensor_TM1,Stimulus_sens_1
k59_56614_1	1121272.KB903290_gene4616	1.52e-46	165.0	COG0025@1|root,COG0025@2|Bacteria,2I37Q@201174|Actinobacteria,4DM5R@85008|Micromonosporales	201174|Actinobacteria	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
k59_112188_1	457396.CSBG_02717	6.51e-25	105.0	COG4377@1|root,COG4377@2|Bacteria,1V3UF@1239|Firmicutes,24JI9@186801|Clostridia,36K76@31979|Clostridiaceae	186801|Clostridia	S	Putative membrane peptidase family (DUF2324)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2324
k59_1668841_1	1237149.C900_00542	1.48e-79	256.0	COG0507@1|root,COG1112@1|root,COG0507@2|Bacteria,COG1112@2|Bacteria,4NEK7@976|Bacteroidetes,47MJ9@768503|Cytophagia	976|Bacteroidetes	L	PFAM Type III restriction enzyme, res subunit	-	-	-	-	-	-	-	-	-	-	-	-	AAA_11,AAA_12
k59_890565_1	340177.Cag_0145	7.93e-23	104.0	COG0323@1|root,COG0323@2|Bacteria,1FDFS@1090|Chlorobi	1090|Chlorobi	J	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
k59_1168516_1	198467.NP92_04855	5.49e-07	54.7	COG0301@1|root,COG0301@2|Bacteria,1TPNW@1239|Firmicutes,4HAV9@91061|Bacilli,21V2X@150247|Anoxybacillus	91061|Bacilli	H	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	thiI	-	2.8.1.4	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07461	-	ko00000,ko00001,ko01000,ko03016	-	-	-	THUMP,ThiI
k59_668171_1	1449126.JQKL01000009_gene309	1.17e-10	64.3	COG1734@1|root,COG1734@2|Bacteria,1V6MF@1239|Firmicutes,24K3N@186801|Clostridia	186801|Clostridia	T	TIGRFAM Sporulation protein YteA	-	-	-	-	-	-	-	-	-	-	-	-	zf-dskA_traR
k59_1557671_1	1430440.MGMSRv2_0891	2.02e-59	207.0	COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,2TRY7@28211|Alphaproteobacteria,2JPFA@204441|Rhodospirillales	204441|Rhodospirillales	H	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	-	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
k59_890587_1	398511.BpOF4_14695	3.84e-39	138.0	COG3576@1|root,COG3576@2|Bacteria,1UZ02@1239|Firmicutes,4HEN8@91061|Bacilli,1ZC4B@1386|Bacillus	91061|Bacilli	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07006	-	-	-	-	ko00000	-	-	-	Putative_PNPOx
k59_1001761_1	930169.B5T_00266	1.68e-189	531.0	COG0191@1|root,COG0191@2|Bacteria,1MURX@1224|Proteobacteria,1RQUC@1236|Gammaproteobacteria,1XHC4@135619|Oceanospirillales	135619|Oceanospirillales	G	catalyzes the reversible aldol condensation of dihydroxyacetonephosphate and glyceraldehyde 3-phosphate in the Calvin cycle, glycolysis and gluconeogenesis	fbaA	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
k59_223384_1	204669.Acid345_2221	2.52e-69	222.0	COG0842@1|root,COG0842@2|Bacteria,3Y2S4@57723|Acidobacteria,2JISC@204432|Acidobacteriia	204432|Acidobacteriia	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
k59_223384_2	344747.PM8797T_04790	2.08e-88	271.0	COG1131@1|root,COG1131@2|Bacteria,2IYFJ@203682|Planctomycetes	203682|Planctomycetes	V	COG1131 ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_779368_1	266265.Bxe_C0490	1.5e-20	91.3	COG3547@1|root,COG3547@2|Bacteria,1MW0N@1224|Proteobacteria,2VWYN@28216|Betaproteobacteria,1K8UX@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Transposase IS116/IS110/IS902 family	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	Transposase_20
k59_779368_2	1038859.AXAU01000052_gene194	3.29e-16	78.2	COG3547@1|root,COG3547@2|Bacteria,1MW0N@1224|Proteobacteria,2TUGE@28211|Alphaproteobacteria,3JX5I@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	PFAM transposase IS116 IS110 IS902 family	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1390926_1	497964.CfE428DRAFT_5622	4.92e-57	180.0	COG3795@1|root,COG3795@2|Bacteria,46V6E@74201|Verrucomicrobia	74201|Verrucomicrobia	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
k59_1390926_2	1459636.NTE_03172	3.85e-07	50.8	COG3865@1|root,arCOG09469@2157|Archaea	2157|Archaea	S	PFAM 3-demethylubiquinone-9	-	-	-	ko:K04750	-	-	-	-	ko00000	-	-	-	3-dmu-9_3-mt
k59_56656_1	1541065.JRFE01000035_gene2789	1.01e-92	275.0	COG1335@1|root,COG1335@2|Bacteria,1G72E@1117|Cyanobacteria,3VMVU@52604|Pleurocapsales	1117|Cyanobacteria	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
k59_668197_1	525368.HMPREF0591_1854	5.77e-42	152.0	COG4974@1|root,COG4974@2|Bacteria,2I9ZX@201174|Actinobacteria,2374G@1762|Mycobacteriaceae	201174|Actinobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_1502102_1	1293048.CBMB010000003_gene1118	3.66e-24	106.0	COG0277@1|root,arCOG00337@2157|Archaea,2XT5C@28890|Euryarchaeota,23SCM@183963|Halobacteria	183963|Halobacteria	C	COG0277 FAD FMN-containing dehydrogenases	-	-	-	-	-	-	-	-	-	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17,Fer4_8
k59_723865_1	1122138.AQUZ01000019_gene8174	6.35e-77	256.0	COG0737@1|root,COG1524@1|root,COG3379@1|root,COG0737@2|Bacteria,COG1524@2|Bacteria,COG3379@2|Bacteria,2HFJ5@201174|Actinobacteria,4DVDK@85009|Propionibacteriales	201174|Actinobacteria	F	5'-nucleotidase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	5_nucleotid_C
k59_1224219_1	1121106.JQKB01000139_gene4053	1.52e-86	267.0	COG1960@1|root,COG1960@2|Bacteria,1MX17@1224|Proteobacteria,2TTRE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	COG1960 Acyl-CoA dehydrogenases	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_556977_2	1121271.AUCM01000015_gene2533	1.57e-13	71.6	COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,2U361@28211|Alphaproteobacteria	28211|Alphaproteobacteria	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	DUF971,ParA
k59_1446607_1	1144310.PMI07_001945	1.55e-57	187.0	COG3836@1|root,COG3836@2|Bacteria,1R9U6@1224|Proteobacteria,2TSTY@28211|Alphaproteobacteria,4B7QE@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Belongs to the HpcH HpaI aldolase family	-	-	-	-	-	-	-	-	-	-	-	-	HpcH_HpaI
k59_334604_1	1121033.AUCF01000003_gene3344	1.8e-75	245.0	COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,2TQRS@28211|Alphaproteobacteria,2JPFZ@204441|Rhodospirillales	204441|Rhodospirillales	O	Molecular chaperone. Has ATPase activity	htpG	-	-	ko:K04079	ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418	-	-	-	ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147	-	-	-	HATPase_c,HATPase_c_3,HSP90
k59_779401_1	1380394.JADL01000001_gene1989	3.06e-58	196.0	COG0477@1|root,COG2814@2|Bacteria,1R7QS@1224|Proteobacteria,2TUXM@28211|Alphaproteobacteria,2JS4J@204441|Rhodospirillales	204441|Rhodospirillales	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_723876_1	234267.Acid_4577	1.28e-80	256.0	COG4993@1|root,COG4993@2|Bacteria,3Y696@57723|Acidobacteria	57723|Acidobacteria	G	PQQ-like domain	-	-	1.1.2.8	ko:K00114	ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130	-	R05062,R05198,R05285	RC00087,RC00088,RC01039	ko00000,ko00001,ko01000	-	-	-	PQQ_2
k59_1224233_1	1128421.JAGA01000002_gene1845	6.34e-75	233.0	COG0623@1|root,COG0623@2|Bacteria	2|Bacteria	I	enoyl-[acyl-carrier-protein] reductase (NADH) activity	fabI	GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0030497,GO:0032787,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:1901576	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_1001817_1	1163389.OOM_1008	4.06e-19	84.0	COG0824@1|root,COG0824@2|Bacteria,1RI3X@1224|Proteobacteria,1S6W9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Thioesterase	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT_2,Acyl-ACP_TE
k59_1001817_2	536227.CcarbDRAFT_0131	8.01e-11	62.8	COG0745@1|root,COG0745@2|Bacteria,1TPRM@1239|Firmicutes,25B4D@186801|Clostridia,36DFT@31979|Clostridiaceae	186801|Clostridia	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
k59_223442_1	224914.BMEII0685	3.24e-80	257.0	COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,2TQPM@28211|Alphaproteobacteria,1J1TE@118882|Brucellaceae	28211|Alphaproteobacteria	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
k59_1224246_2	234267.Acid_4494	5.24e-15	73.2	COG1595@1|root,COG1595@2|Bacteria,3Y7YB@57723|Acidobacteria	2|Bacteria	K	RNA polymerase, sigma-24 subunit, ECF subfamily	-	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_ECF
k59_1224248_1	1040989.AWZU01000019_gene1851	1.11e-31	122.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,2TRBG@28211|Alphaproteobacteria,3JUJQ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	coxN	GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0022900,GO:0022904,GO:0034220,GO:0044237,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_1224248_2	1089551.KE386572_gene4252	2.13e-47	160.0	COG1622@1|root,COG1622@2|Bacteria,1MVYW@1224|Proteobacteria,2TT5C@28211|Alphaproteobacteria,4BRRM@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Cytochrome C oxidase subunit II, periplasmic domain	coxM	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009319,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034641,GO:0042773,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0055086,GO:0055114,GO:0070069,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2
k59_1279816_1	591158.SSMG_03101	1.67e-39	149.0	COG2936@1|root,COG2936@2|Bacteria,2GK8B@201174|Actinobacteria	201174|Actinobacteria	IQ	Peptidase S15	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
k59_167898_1	379066.GAU_1314	4.05e-95	310.0	COG3696@1|root,COG3696@2|Bacteria,1ZUB0@142182|Gemmatimonadetes	2|Bacteria	P	AcrB/AcrD/AcrF family	cusA	-	-	ko:K07787,ko:K15726	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.2,2.A.6.1.4	-	iAF987.Gmet_1547	ACR_tran
k59_1168611_2	1089548.KI783301_gene2347	3.36e-10	65.1	COG1525@1|root,COG1525@2|Bacteria,1V3MZ@1239|Firmicutes,4HHPS@91061|Bacilli,3WFNQ@539002|Bacillales incertae sedis	91061|Bacilli	L	Staphylococcal nuclease homologues	nucH	-	3.1.31.1	ko:K01174	-	-	-	-	ko00000,ko01000	-	-	-	SNase
k59_668271_1	1121335.Clst_2530	1.02e-45	155.0	COG0088@1|root,COG0088@2|Bacteria,1TPGW@1239|Firmicutes,248SY@186801|Clostridia,3WGQT@541000|Ruminococcaceae	186801|Clostridia	J	Forms part of the polypeptide exit tunnel	rplD	-	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
k59_779439_1	713586.KB900536_gene1289	5.55e-14	76.6	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1S720@1236|Gammaproteobacteria,1WYW3@135613|Chromatiales	135613|Chromatiales	O	Tetratricopeptide repeats	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_8,Trans_reg_C
k59_723919_1	710111.FraQA3DRAFT_1080	9.63e-73	241.0	COG4770@1|root,COG4770@2|Bacteria,2GIZP@201174|Actinobacteria,4ES90@85013|Frankiales	201174|Actinobacteria	I	Carbamoyl-phosphate synthase L chain	accA1	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	6.3.4.14,6.4.1.2,6.4.1.3,6.4.1.4	ko:K01968,ko:K11263	ko00061,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01212	M00036,M00082,M00741	R00742,R01859,R04138,R04385	RC00040,RC00097,RC00253,RC00367,RC00609,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2501c	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
k59_1169665_1	1207063.P24_03291	1.39e-86	268.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,2TT2J@28211|Alphaproteobacteria,2JPYA@204441|Rhodospirillales	204441|Rhodospirillales	P	COG0004 Ammonia permease	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp,MCPsignal
k59_502547_1	58123.JOFJ01000004_gene1624	1.16e-57	191.0	COG0012@1|root,COG0012@2|Bacteria,2GIXI@201174|Actinobacteria,4EH8N@85012|Streptosporangiales	201174|Actinobacteria	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
k59_447006_1	143224.JQMD01000002_gene2750	4.63e-09	56.2	COG1309@1|root,COG1309@2|Bacteria,4NPM1@976|Bacteroidetes,1I1Z1@117743|Flavobacteriia	976|Bacteroidetes	K	TetR family transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_447006_2	247156.NFA_38450	1.32e-26	107.0	COG3576@1|root,COG3576@2|Bacteria,2GP9M@201174|Actinobacteria,4FW1N@85025|Nocardiaceae	201174|Actinobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07006	-	-	-	-	ko00000	-	-	-	Putative_PNPOx
k59_335668_1	1247963.JPHU01000005_gene444	1.29e-15	77.0	COG3950@1|root,COG3950@2|Bacteria,1MUE0@1224|Proteobacteria,2U5YT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	protein involved in virulence	-	-	-	-	-	-	-	-	-	-	-	-	AAA_21,AAA_23
k59_391387_1	34007.IT40_19865	5.26e-34	131.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQMJ@28211|Alphaproteobacteria,2PWCI@265|Paracoccus	28211|Alphaproteobacteria	E	Belongs to the ABC transporter superfamily	-	-	-	ko:K02052	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	ABC_tran,TOBE_2
k59_891798_1	85643.Tmz1t_1268	1.44e-82	252.0	COG1346@1|root,COG1346@2|Bacteria,1MV81@1224|Proteobacteria,2VH4N@28216|Betaproteobacteria,2KVYR@206389|Rhodocyclales	206389|Rhodocyclales	M	of murein hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	LrgB
k59_113370_1	864051.BurJ1DRAFT_2685	3.26e-28	116.0	COG4117@1|root,COG4117@2|Bacteria,1R4HB@1224|Proteobacteria,2WFJG@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Cytochrome b/b6/petB	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
k59_113370_2	314285.KT71_18426	9.03e-42	149.0	28I8B@1|root,2Z8B5@2|Bacteria,1MUNM@1224|Proteobacteria,1RQ1H@1236|Gammaproteobacteria,1J4H2@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Cytochrome c bacterial	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Cytochrome_cB
k59_1336486_1	1342299.Z947_1192	1.05e-23	93.6	COG0640@1|root,COG0640@2|Bacteria,1MZAU@1224|Proteobacteria,2U9NV@28211|Alphaproteobacteria,3ZXMC@60136|Sulfitobacter	28211|Alphaproteobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	arsR	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20
k59_1336486_2	391937.NA2_19316	4.5e-51	171.0	COG0798@1|root,COG0798@2|Bacteria,1MUXY@1224|Proteobacteria,2TSVJ@28211|Alphaproteobacteria,43HFQ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	Sodium Bile acid symporter family	-	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
k59_1058463_1	179408.Osc7112_2555	7.72e-77	234.0	COG1335@1|root,COG1335@2|Bacteria,1G3QK@1117|Cyanobacteria,1HEG7@1150|Oscillatoriales	1117|Cyanobacteria	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
k59_558076_1	1218075.BAYA01000038_gene6373	0.000756	47.8	COG2199@1|root,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,2W094@28216|Betaproteobacteria,1KFC1@119060|Burkholderiaceae	28216|Betaproteobacteria	T	PFAM GGDEF domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS_4
k59_1503222_2	1121946.AUAX01000009_gene4520	1.64e-23	101.0	COG1555@1|root,COG1555@2|Bacteria,2IQDC@201174|Actinobacteria,4DDIY@85008|Micromonosporales	201174|Actinobacteria	L	competence protein ComEA helix-hairpin-helix repeat protein	comEA	-	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3,SLBB
k59_1447796_1	935548.KI912159_gene1319	3.07e-71	228.0	COG2072@1|root,COG2072@2|Bacteria,1MWPJ@1224|Proteobacteria,2TSQA@28211|Alphaproteobacteria,43QZP@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	L-lysine 6-monooxygenase (NADPH-requiring)	-	-	-	ko:K07222	-	-	-	-	ko00000	-	-	-	Pyr_redox_3
k59_1225489_1	926569.ANT_28860	4.18e-58	202.0	COG1198@1|root,COG1198@2|Bacteria,2G60J@200795|Chloroflexi	200795|Chloroflexi	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
k59_725081_1	1131814.JAFO01000001_gene3834	8.37e-23	95.9	2BKYI@1|root,32FF5@2|Bacteria,1MY1A@1224|Proteobacteria,2U1KI@28211|Alphaproteobacteria,3EZUF@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctB family	-	-	-	-	-	-	-	-	-	-	-	-	TctB
k59_947381_1	379066.GAU_0047	1.36e-68	214.0	COG2755@1|root,COG2755@2|Bacteria,1ZUS0@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	GDSL-like Lipase/Acylhydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
k59_1558871_1	416591.Tlet_1950	5.38e-75	237.0	COG0205@1|root,COG0205@2|Bacteria,2GC8H@200918|Thermotogae	200918|Thermotogae	F	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
k59_1114267_1	1150864.MILUP08_42621	0.000488	43.1	COG0283@1|root,COG0283@2|Bacteria,2H3SI@201174|Actinobacteria,4D918@85008|Micromonosporales	201174|Actinobacteria	F	Belongs to the cytidylate kinase family. Type 1 subfamily	cmk	GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0040007,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin
k59_1114267_2	1288494.EBAPG3_23300	8.92e-36	134.0	COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,2VI12@28216|Betaproteobacteria,372RZ@32003|Nitrosomonadales	28216|Betaproteobacteria	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
k59_1558876_1	1415774.U728_98	4.8e-09	60.1	COG1125@1|root,COG1125@2|Bacteria,1TPV8@1239|Firmicutes,248YZ@186801|Clostridia,36EGJ@31979|Clostridiaceae	186801|Clostridia	E	glycine, betaine	-	-	-	ko:K05847	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	ABC_tran
k59_1614390_1	1304874.JAFY01000002_gene169	1.66e-22	97.4	COG0500@1|root,COG2226@2|Bacteria,3TAMQ@508458|Synergistetes	508458|Synergistetes	Q	PFAM methyltransferase	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
k59_558110_1	342113.DM82_2988	1.33e-22	99.0	COG0412@1|root,COG0412@2|Bacteria,1MW88@1224|Proteobacteria,2VQD1@28216|Betaproteobacteria,1JZSD@119060|Burkholderiaceae	28216|Betaproteobacteria	Q	Carboxymethylenebutenolidase	clcD	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
k59_1114284_1	4577.GRMZM2G455809_P01	1.51e-14	74.7	COG1028@1|root,KOG0725@2759|Eukaryota,37S3J@33090|Viridiplantae,3GF7T@35493|Streptophyta,3KQT1@4447|Liliopsida,3IDG5@38820|Poales	35493|Streptophyta	Q	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	3.6.4.12	ko:K15255	-	-	-	-	ko00000,ko01000,ko03029,ko03032	-	-	-	adh_short_C2
k59_502616_1	1123242.JH636434_gene5621	2.34e-76	243.0	COG0702@1|root,COG0702@2|Bacteria,2IYQV@203682|Planctomycetes	203682|Planctomycetes	GM	PFAM NAD-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2867,NAD_binding_10
k59_1725639_1	686340.Metal_1558	1.11e-76	242.0	COG0538@1|root,COG0538@2|Bacteria,1MW3J@1224|Proteobacteria,1RNMD@1236|Gammaproteobacteria,1XEUJ@135618|Methylococcales	135618|Methylococcales	C	Isocitrate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Iso_dh
k59_280231_1	882083.SacmaDRAFT_0798	9.7e-57	199.0	COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,4DYKC@85010|Pseudonocardiales	201174|Actinobacteria	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	GO:0000731,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0018130,GO:0019438,GO:0019985,GO:0030312,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042276,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:1901360,GO:1901362,GO:1901576	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_669461_2	1122201.AUAZ01000005_gene625	1.55e-66	224.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,464J4@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	cusA	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	-	ACR_tran
k59_1558897_1	373903.Hore_02340	8.48e-07	50.1	COG0064@1|root,COG0064@2|Bacteria,1TPG3@1239|Firmicutes,247MS@186801|Clostridia,3WAGA@53433|Halanaerobiales	186801|Clostridia	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
k59_1558897_2	1196031.ALEG01000008_gene5027	2.51e-15	79.3	COG0438@1|root,COG0438@2|Bacteria,1V346@1239|Firmicutes,4HGT4@91061|Bacilli,1ZEK1@1386|Bacillus	91061|Bacilli	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
k59_1670128_1	313589.JNB_10069	7.2e-25	103.0	COG0491@1|root,COG0491@2|Bacteria,2GKP9@201174|Actinobacteria,4FEJY@85021|Intrasporangiaceae	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	pksB_1	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_947429_1	711393.AYRX01000010_gene2544	3.5e-65	207.0	COG1521@1|root,COG1521@2|Bacteria,2GMRQ@201174|Actinobacteria	201174|Actinobacteria	H	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Pan_kinase
k59_72955_1	83406.HDN1F_09860	8.59e-113	329.0	COG0664@1|root,COG0664@2|Bacteria,1MVGE@1224|Proteobacteria,1RPTB@1236|Gammaproteobacteria,1J54F@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	Catabolite gene activator and regulatory subunit of cAMP-dependent protein	anr	-	-	ko:K01420	-	-	-	-	ko00000,ko03000	-	-	-	Crp,HTH_Crp_2,cNMP_binding
k59_406779_1	344747.PM8797T_31810	1.32e-26	112.0	COG0515@1|root,COG0515@2|Bacteria,2IY6U@203682|Planctomycetes	203682|Planctomycetes	KLT	COG0515 Serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
k59_1463135_1	713586.KB900536_gene2289	1.77e-15	78.2	COG2801@1|root,COG2801@2|Bacteria,1MZ45@1224|Proteobacteria,1RSNX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	COG2801 Transposase and inactivated derivatives	ylbG	-	-	-	-	-	-	-	-	-	-	-	HTH_29,rve,rve_2,rve_3
k59_1463135_2	216432.CA2559_06995	2.03e-07	52.0	COG2323@1|root,COG2323@2|Bacteria,4NR3N@976|Bacteroidetes,1IIDW@117743|Flavobacteriia	976|Bacteroidetes	S	Protein of unknown function (DUF421)	-	-	-	-	-	-	-	-	-	-	-	-	DUF421
k59_1351709_1	926560.KE387023_gene1741	1.2e-06	52.8	COG0778@1|root,COG0778@2|Bacteria,1WKT5@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
k59_1351709_2	665959.HMPREF1013_03172	3.86e-05	45.8	COG0145@1|root,COG0145@2|Bacteria,1TQVB@1239|Firmicutes,4HB8X@91061|Bacilli,1ZAQW@1386|Bacillus	91061|Bacilli	EQ	COG0145 N-methylhydantoinase A acetone carboxylase, beta subunit	-	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
k59_850610_1	414684.RC1_1691	1.69e-21	92.8	COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,2TQUZ@28211|Alphaproteobacteria,2JPMS@204441|Rhodospirillales	204441|Rhodospirillales	O	Belongs to the ClpA ClpB family	clpA	-	-	ko:K03694	-	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_850610_2	1054213.HMPREF9946_03616	4.5e-54	172.0	COG2127@1|root,COG2127@2|Bacteria,1MZU8@1224|Proteobacteria,2U982@28211|Alphaproteobacteria,2JSWP@204441|Rhodospirillales	204441|Rhodospirillales	S	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation	clpS	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
k59_17744_1	331869.BAL199_27206	3.33e-75	232.0	COG0412@1|root,COG0412@2|Bacteria,1R9JT@1224|Proteobacteria,2U4J1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	BAAT / Acyl-CoA thioester hydrolase C terminal	-	-	-	-	-	-	-	-	-	-	-	-	DLH
k59_463096_1	926550.CLDAP_41140	4.64e-65	206.0	COG0020@1|root,COG0020@2|Bacteria,2G65C@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
k59_127886_1	861299.J421_4164	1.77e-50	173.0	COG0767@1|root,COG0767@2|Bacteria,1ZSUC@142182|Gemmatimonadetes	142182|Gemmatimonadetes	Q	Permease MlaE	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
k59_1685398_1	1267534.KB906760_gene1426	4.48e-95	298.0	COG1217@1|root,COG1217@2|Bacteria,3Y33Q@57723|Acidobacteria,2JIIC@204432|Acidobacteriia	204432|Acidobacteriia	T	GTP-binding protein TypA	-	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
k59_127889_1	536019.Mesop_1867	7.04e-82	253.0	COG3173@1|root,COG3173@2|Bacteria,1MWAK@1224|Proteobacteria,2TT2N@28211|Alphaproteobacteria,43IRA@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Aminoglycoside phosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	APH
k59_1685402_1	981085.XP_010092922.1	8.65e-57	197.0	COG0481@1|root,COG2801@1|root,KOG0017@2759|Eukaryota,KOG0462@2759|Eukaryota,37K2D@33090|Viridiplantae,3GBUJ@35493|Streptophyta,4JMDZ@91835|fabids	35493|Streptophyta	J	GTP-binding protein TypA	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009266,GO:0009409,GO:0009507,GO:0009536,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0031647,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050821,GO:0050896,GO:0065007,GO:0065008,GO:0071704,GO:0071840,GO:0090304,GO:1901360	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
k59_962811_1	390989.JOEG01000009_gene1127	2.38e-66	211.0	COG0667@1|root,COG0667@2|Bacteria,2GMNA@201174|Actinobacteria,4D93W@85008|Micromonosporales	201174|Actinobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_1018888_1	1122135.KB893134_gene3912	1.51e-85	261.0	COG2041@1|root,COG2041@2|Bacteria,1MUW0@1224|Proteobacteria,2TS40@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide	msrP	-	-	ko:K07147	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_molyb
k59_796132_1	1054213.HMPREF9946_02777	7.36e-33	117.0	2CIU6@1|root,32S8H@2|Bacteria,1MZTN@1224|Proteobacteria,2UCA8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_796132_2	1122214.AQWH01000008_gene1372	2.6e-11	64.3	COG3185@1|root,COG3185@2|Bacteria,1MVR0@1224|Proteobacteria,2TTAD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Acyclic terpene utilisation family protein AtuA	-	-	-	-	-	-	-	-	-	-	-	-	AtuA
k59_1351752_1	1231241.Mc24_01489	4.03e-106	316.0	COG0820@1|root,COG0820@2|Bacteria,2GC4T@200918|Thermotogae	200918|Thermotogae	J	PFAM Radical SAM domain protein	-	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	-
k59_1018899_1	760192.Halhy_2134	1.54e-73	234.0	COG1228@1|root,COG1228@2|Bacteria,4NFI3@976|Bacteroidetes,1IWRU@117747|Sphingobacteriia	976|Bacteroidetes	Q	COGs COG1228 Imidazolonepropionase and related amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_183984_1	324925.Ppha_0603	3.71e-48	169.0	COG5433@1|root,COG5433@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k59_1518438_2	926569.ANT_07440	3.37e-40	142.0	COG1355@1|root,COG1355@2|Bacteria,2G6V0@200795|Chloroflexi	200795|Chloroflexi	S	Belongs to the MEMO1 family	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	AMMECR1,Memo
k59_463158_1	1416752.AYME01000005_gene1829	5.63e-12	69.7	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4FKZR@85023|Microbacteriaceae	201174|Actinobacteria	IQ	AMP-binding enzyme C-terminal domain	fadD2	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
k59_962854_1	247490.KSU1_C0323	1.3e-41	147.0	COG1657@1|root,COG1657@2|Bacteria	2|Bacteria	I	PFAM Prenyltransferase squalene oxidase	-	-	-	-	-	-	-	-	-	-	-	-	A2M_comp,DUF4159,Prenyltrans
k59_1574153_1	1239962.C943_01963	6.87e-44	157.0	COG0028@1|root,COG0028@2|Bacteria,4NENG@976|Bacteroidetes,47KS8@768503|Cytophagia	976|Bacteroidetes	EH	TIGRFAM acetolactate synthase, large subunit, biosynthetic type	-	-	2.2.1.6,4.1.1.7	ko:K01576,ko:K01652	ko00290,ko00627,ko00650,ko00660,ko00770,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00290,map00627,map00650,map00660,map00770,map01100,map01110,map01120,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R01764,R02672,R03050,R04672,R04673,R08648	RC00027,RC00106,RC00595,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_572904_2	96561.Dole_0563	1.89e-64	202.0	2A4CF@1|root,30SY3@2|Bacteria,1RFXP@1224|Proteobacteria,42RIM@68525|delta/epsilon subdivisions,2WNS6@28221|Deltaproteobacteria,2MNMZ@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Yip1
k59_572904_3	1122611.KB903943_gene1482	1.11e-12	68.2	COG0029@1|root,COG0157@1|root,COG0029@2|Bacteria,COG0157@2|Bacteria,2I2IJ@201174|Actinobacteria,4EFXC@85012|Streptosporangiales	201174|Actinobacteria	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	nadB	-	1.4.3.16,2.4.2.19	ko:K00278,ko:K00767	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481,R03348	RC00006,RC02566,RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_1296058_1	1033734.CAET01000027_gene885	3.1e-05	52.4	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1TR2N@1239|Firmicutes,4H9RR@91061|Bacilli,1ZB2Q@1386|Bacillus	91061|Bacilli	EU	peptidase	yuxL	-	3.4.19.1	ko:K01303	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S9
k59_240130_2	584708.Apau_1883	2.54e-35	125.0	COG1848@1|root,COG1848@2|Bacteria	2|Bacteria	G	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN,PIN_3
k59_1685503_1	632518.Calow_0515	1.75e-18	89.4	COG0760@1|root,COG0760@2|Bacteria,1TX3R@1239|Firmicutes,24C7H@186801|Clostridia,42GQY@68295|Thermoanaerobacterales	186801|Clostridia	M	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins	prsA	-	5.2.1.8	ko:K03769,ko:K07533	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_2,SurA_N_3
k59_850730_1	1121374.KB891580_gene1793	1.99e-25	100.0	COG0801@1|root,COG0801@2|Bacteria,1MZH8@1224|Proteobacteria,1S63J@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	GO:0000287,GO:0003674,GO:0003824,GO:0003848,GO:0005488,GO:0016740,GO:0016772,GO:0016778,GO:0043167,GO:0043169,GO:0046872	2.7.6.3	ko:K00950	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	iECDH1ME8569_1439.ECDH1ME8569_0136,iEcDH1_1363.EcDH1_3460,iJN746.PP_4698,iSBO_1134.SBO_0131	HPPK
k59_850730_2	1177154.Y5S_01503	2.75e-17	82.4	COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,1RMBG@1236|Gammaproteobacteria,1XHIH@135619|Oceanospirillales	135619|Oceanospirillales	J	Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control	pcnB	-	2.7.7.19	ko:K00970	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PolyA_pol,PolyA_pol_RNAbd,PolyA_pol_arg_C
k59_850736_1	1381123.AYOD01000044_gene1759	4.62e-95	288.0	COG1363@1|root,COG1363@2|Bacteria,1MXEU@1224|Proteobacteria,2TSPX@28211|Alphaproteobacteria,43IWM@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	M42 glutamyl aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
k59_1185083_1	1894.JOER01000049_gene5085	2.29e-35	138.0	COG0076@1|root,COG0076@2|Bacteria	2|Bacteria	E	glutamate decarboxylase activity	tdc	-	4.1.1.25	ko:K22330	ko00350,map00350	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyridoxal_deC
k59_1186881_1	1192124.LIG30_2229	1.04e-26	100.0	COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,2VSEZ@28216|Betaproteobacteria,1K7MM@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Belongs to the P(II) protein family	glnK	-	-	ko:K04752	-	-	-	-	ko00000	-	-	-	P-II
k59_1186881_2	314278.NB231_09038	4.1e-28	113.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,1WWT4@135613|Chromatiales	135613|Chromatiales	U	Ammonium transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_1520323_1	998674.ATTE01000001_gene1643	1.41e-37	130.0	COG1285@1|root,COG1285@2|Bacteria,1MURJ@1224|Proteobacteria,1S65I@1236|Gammaproteobacteria,462YF@72273|Thiotrichales	72273|Thiotrichales	S	MgtC family	-	-	-	-	-	-	-	-	-	-	-	-	MgtC
k59_1520323_2	66377.JOBH01000006_gene35	2.85e-07	51.2	COG2141@1|root,COG2141@2|Bacteria,2GM94@201174|Actinobacteria	201174|Actinobacteria	C	Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone	fgd_1	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_798023_1	204773.HEAR0260	7.25e-51	174.0	COG3971@1|root,COG3971@2|Bacteria,1RGHI@1224|Proteobacteria,2VRTF@28216|Betaproteobacteria,473R4@75682|Oxalobacteraceae	28216|Betaproteobacteria	Q	2-keto-4-pentenoate hydratase	mhpD	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
k59_687261_1	224911.27355206	3.72e-28	116.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQPG@28211|Alphaproteobacteria,3JX63@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Regulator	hoxA	-	-	ko:K19641	ko02020,map02020	M00772	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1576052_1	266117.Rxyl_0453	8.47e-09	59.3	COG2380@1|root,COG2380@2|Bacteria	2|Bacteria	NU	COGs COG2380 conserved	-	-	-	ko:K09785	-	-	-	-	ko00000	-	-	-	NurA
k59_1298061_1	926569.ANT_15080	3.44e-29	120.0	COG1572@1|root,COG1572@2|Bacteria,2G9M8@200795|Chloroflexi	2|Bacteria	S	Ig-like domain from next to BRCA1 gene	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,N_BRCA1_IG
k59_909986_1	1122621.ATZA01000033_gene516	6.02e-06	51.2	COG2183@1|root,COG2183@2|Bacteria,4NETD@976|Bacteroidetes,1IPB3@117747|Sphingobacteriia	976|Bacteroidetes	K	Tex-like protein N-terminal domain	yhgF	-	-	ko:K06959	-	-	-	-	ko00000	-	-	-	HHH_3,S1,Tex_N,Tex_YqgF
k59_909986_2	1123373.ATXI01000007_gene1764	1.14e-20	90.5	COG0527@1|root,COG0527@2|Bacteria,2GGWG@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	E	Belongs to the aspartokinase family	-	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
k59_1186912_1	266779.Meso_3021	2.05e-49	172.0	COG2309@1|root,COG2309@2|Bacteria,1MW2Y@1224|Proteobacteria,2TSGB@28211|Alphaproteobacteria,43I54@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Leucyl aminopeptidase (Aminopeptidase T)	ampS	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
k59_1020852_1	208439.AJAP_20380	1.75e-28	113.0	COG4301@1|root,COG4301@2|Bacteria,2GJAX@201174|Actinobacteria,4DYPU@85010|Pseudonocardiales	201174|Actinobacteria	S	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine	egtD	-	2.1.1.44	ko:K18911	ko00340,map00340	-	R01169	RC00003,RC02308	ko00000,ko00001,ko01000	-	-	-	Methyltransf_33
k59_1520341_2	440512.C211_15655	4.37e-18	87.8	COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	mechanosensitive ion channel	kefA	GO:0005575,GO:0005623,GO:0005886,GO:0006884,GO:0008150,GO:0008361,GO:0009987,GO:0009992,GO:0016020,GO:0016043,GO:0019725,GO:0030104,GO:0032535,GO:0042592,GO:0044464,GO:0048878,GO:0055082,GO:0065007,GO:0065008,GO:0071840,GO:0071944,GO:0090066	-	ko:K05802,ko:K22051	-	-	-	-	ko00000,ko02000	1.A.23.1.1,1.A.23.1.2,1.A.23.1.3	-	-	MS_channel,MscS_TM,MscS_porin
k59_185923_1	570952.ATVH01000013_gene2874	3.21e-85	259.0	COG1250@1|root,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2TR8E@28211|Alphaproteobacteria,2JPY1@204441|Rhodospirillales	204441|Rhodospirillales	I	Dehydrogenase	hbdA	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
k59_1630893_1	118168.MC7420_5670	1.97e-38	140.0	COG3875@1|root,COG3875@2|Bacteria,1G82E@1117|Cyanobacteria,1HDBH@1150|Oscillatoriales	1117|Cyanobacteria	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
k59_909994_1	1123518.ARWI01000001_gene400	1.26e-64	218.0	COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,1RN49@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	COG0577 ABC-type antimicrobial peptide transport system permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_241884_1	671143.DAMO_0276	2.18e-102	306.0	COG0192@1|root,COG0192@2|Bacteria,2NNYF@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
k59_1742624_1	861299.J421_2659	2.31e-52	187.0	COG0612@1|root,COG0612@2|Bacteria,1ZT1M@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Insulinase (Peptidase family M16)	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_687287_1	381666.H16_A2060	3.7e-77	251.0	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,2VIDE@28216|Betaproteobacteria,1K0GW@119060|Burkholderiaceae	28216|Betaproteobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
k59_19701_1	1267535.KB906767_gene1242	7.57e-156	458.0	COG2159@1|root,COG3328@1|root,COG2159@2|Bacteria,COG3328@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	Amidohydro_2,DDE_Tnp_1_4,Transposase_mut
k59_130011_1	103733.JNYO01000005_gene8693	6.14e-39	144.0	COG3844@1|root,COG3844@2|Bacteria,2GMJQ@201174|Actinobacteria,4DXB9@85010|Pseudonocardiales	201174|Actinobacteria	E	Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively	kynU	-	3.7.1.3	ko:K01556	ko00380,ko01100,map00380,map01100	M00038	R00987,R02668,R03936	RC00284,RC00415	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5
k59_1186949_1	83406.HDN1F_14690	8.95e-116	341.0	COG1868@1|root,COG1868@2|Bacteria,1MX01@1224|Proteobacteria,1RQ8M@1236|Gammaproteobacteria,1J4Q8@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	N	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation	fliM	-	-	ko:K02416	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliM,FliMN_C
k59_19721_1	675635.Psed_1388	8.6e-15	72.8	COG1917@1|root,COG1917@2|Bacteria,2IP0F@201174|Actinobacteria,4E781@85010|Pseudonocardiales	201174|Actinobacteria	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_798085_1	1123368.AUIS01000005_gene433	3.22e-77	240.0	COG2116@1|root,COG2116@2|Bacteria,1N8YM@1224|Proteobacteria,1RPJ0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Formate nitrite	yfdC	GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006855,GO:0008028,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015238,GO:0015318,GO:0015499,GO:0015711,GO:0015718,GO:0015724,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0042891,GO:0042895,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098656,GO:1903825,GO:1905039	-	ko:K21990	-	-	-	-	ko00000	1.A.16.4	-	-	Form_Nir_trans
k59_1020898_1	880073.Calab_2187	1.19e-32	119.0	COG0432@1|root,COG0432@2|Bacteria,2NPR7@2323|unclassified Bacteria	2|Bacteria	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
k59_1465166_1	448385.sce1458	0.000144	49.7	COG2267@1|root,COG2267@2|Bacteria,1REM6@1224|Proteobacteria,42VM4@68525|delta/epsilon subdivisions,2WRYC@28221|Deltaproteobacteria,2Z398@29|Myxococcales	28221|Deltaproteobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
k59_1409536_2	1487921.DP68_02125	6.38e-08	54.3	2ENBK@1|root,33FZ7@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_241936_1	179408.Osc7112_0527	2.66e-11	69.3	COG2931@1|root,COG2931@2|Bacteria,1G0ZC@1117|Cyanobacteria,1H8KD@1150|Oscillatoriales	1117|Cyanobacteria	Q	PFAM Hemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Calx-beta,Chlam_PMP,DUF4347,HemolysinCabind
k59_19752_1	1449065.JMLL01000013_gene2644	1.24e-25	101.0	2ECJT@1|root,336HX@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_19752_2	1131462.DCF50_p1697	1.17e-26	100.0	COG5646@1|root,COG5646@2|Bacteria,1V6QB@1239|Firmicutes,24K4J@186801|Clostridia,262M5@186807|Peptococcaceae	186801|Clostridia	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801,OmdA
k59_852537_1	926550.CLDAP_13880	1.23e-37	144.0	COG0642@1|root,COG2199@1|root,COG2205@2|Bacteria,COG3706@2|Bacteria	2|Bacteria	T	GGDEF domain	-	-	4.6.1.1	ko:K01768,ko:K20977	ko00230,ko02020,ko02025,ko04113,ko04213,map00230,map02020,map02025,map04113,map04213	M00695,M00820	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko02022	-	-	-	GAF,HATPase_c,HATPase_c_2,HisKA,Response_reg,SpoIIE
k59_1630979_2	1244869.H261_01557	4.25e-16	71.6	2ERCE@1|root,33IY3@2|Bacteria,1NNN9@1224|Proteobacteria,2UXY5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_19766_1	226899.F0XSW0	3.04e-27	108.0	2D1C9@1|root,2SHJW@2759|Eukaryota,3A3AY@33154|Opisthokonta,3P306@4751|Fungi,3RBIM@4890|Ascomycota,21C4J@147550|Sordariomycetes	4751|Fungi	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
k59_1298167_1	1123354.AUDR01000018_gene1196	1.17e-30	123.0	COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,2VHJV@28216|Betaproteobacteria,1KRYW@119069|Hydrogenophilales	119069|Hydrogenophilales	D	Ftsk_gamma	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
k59_630391_1	1121861.KB899915_gene1931	2.79e-08	53.1	COG4957@1|root,COG4957@2|Bacteria,1RGUW@1224|Proteobacteria,2U99M@28211|Alphaproteobacteria,2JS61@204441|Rhodospirillales	204441|Rhodospirillales	K	ROS/MUCR transcriptional regulator protein	-	-	-	-	-	-	-	-	-	-	-	-	ROS_MUCR
k59_255024_1	502025.Hoch_4753	5.19e-61	204.0	COG2203@1|root,COG2204@1|root,COG2203@2|Bacteria,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria	1224|Proteobacteria	T	Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HTH_8,Pkinase,Sigma54_activat,TPR_12
k59_480087_1	671143.DAMO_1674	2.2e-29	117.0	COG2801@1|root,COG2801@2|Bacteria	2|Bacteria	L	transposition	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
k59_979715_2	886377.Murru_2401	3.56e-49	168.0	COG3394@1|root,COG3394@2|Bacteria,4NFY5@976|Bacteroidetes,1HZV4@117743|Flavobacteriia	976|Bacteroidetes	G	YdjC-like protein	-	-	3.5.1.105	ko:K03478	-	-	-	-	ko00000,ko01000	-	-	-	YdjC
k59_533681_1	1410620.SHLA_23c000470	6.13e-10	60.8	COG0010@1|root,COG0010@2|Bacteria,1MVFH@1224|Proteobacteria,2TT0P@28211|Alphaproteobacteria,4B7IA@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Arginase family	-	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
k59_533681_2	911045.PSE_2907	1.85e-12	69.3	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2TQY9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	transport system fused permease components	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_33019_1	1380391.JIAS01000015_gene264	1.37e-52	180.0	COG0403@1|root,COG0403@2|Bacteria,1MVC1@1224|Proteobacteria,2TR6C@28211|Alphaproteobacteria,2JPH3@204441|Rhodospirillales	204441|Rhodospirillales	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
k59_199144_1	861299.J421_2633	1.43e-45	170.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
k59_643551_1	1280673.AUJJ01000008_gene567	3.52e-28	115.0	COG1804@1|root,COG1804@2|Bacteria,1TP54@1239|Firmicutes,24AFB@186801|Clostridia,4BY37@830|Butyrivibrio	186801|Clostridia	C	CoA-transferase family III	-	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
k59_701494_1	338963.Pcar_3002	7.26e-43	153.0	COG0845@1|root,COG0845@2|Bacteria,1R443@1224|Proteobacteria,43A2V@68525|delta/epsilon subdivisions,2X238@28221|Deltaproteobacteria,43VF8@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Biotin-lipoyl like	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
k59_1258263_1	468059.AUHA01000003_gene1658	1.88e-07	58.2	COG0702@1|root,COG0702@2|Bacteria,4NEDB@976|Bacteroidetes,1INX2@117747|Sphingobacteriia	976|Bacteroidetes	GM	Ragb susd	-	-	-	ko:K21572	-	-	-	-	ko00000,ko02000	8.A.46.1,8.A.46.3	-	-	SusD-like_3,SusD_RagB
k59_1090121_1	477641.MODMU_4255	4.16e-45	160.0	COG1506@1|root,COG1506@2|Bacteria,2H90U@201174|Actinobacteria,4EVJW@85013|Frankiales	201174|Actinobacteria	E	Tannase and feruloyl esterase	-	-	-	-	-	-	-	-	-	-	-	-	Tannase
k59_533710_1	1379270.AUXF01000001_gene2824	1.08e-93	290.0	COG2804@1|root,COG2804@2|Bacteria,1ZSSN@142182|Gemmatimonadetes	142182|Gemmatimonadetes	NU	Type II secretion system (T2SS), protein E, N-terminal domain	-	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
k59_312170_1	1254432.SCE1572_34605	4.48e-80	258.0	COG3464@1|root,COG3464@2|Bacteria,1NPPU@1224|Proteobacteria,43BG7@68525|delta/epsilon subdivisions,2X6UI@28221|Deltaproteobacteria,2Z33P@29|Myxococcales	1224|Proteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1534128_1	1499967.BAYZ01000116_gene3144	0.000614	47.4	COG2114@1|root,COG2203@1|root,COG2114@2|Bacteria,COG2203@2|Bacteria,2NP16@2323|unclassified Bacteria	2|Bacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	BLUF,GAF_2,GAF_3,Guanylate_cyc,HAMP,HATPase_c,HisKA,Response_reg
k59_312183_1	1123060.JONP01000014_gene4073	9.84e-24	94.0	COG0186@1|root,COG0186@2|Bacteria,1MZIK@1224|Proteobacteria,2UBRF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
k59_312183_2	1335757.SPICUR_08245	2.26e-14	68.2	COG0255@1|root,COG0255@2|Bacteria,1N6PR@1224|Proteobacteria,1SCBN@1236|Gammaproteobacteria,1WZ6K@135613|Chromatiales	135613|Chromatiales	J	Belongs to the universal ribosomal protein uL29 family	rpmC	-	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
k59_1479440_1	1249627.D779_1480	2.74e-61	208.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RR0R@1236|Gammaproteobacteria,1WWF9@135613|Chromatiales	1236|Gammaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	-	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_1146300_1	388413.ALPR1_09805	2.41e-67	219.0	COG3119@1|root,COG3119@2|Bacteria,4NFRB@976|Bacteroidetes,47TC8@768503|Cytophagia	976|Bacteroidetes	P	C-terminal region of aryl-sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase,Sulfatase_C
k59_1643891_1	398525.KB900701_gene858	6.03e-100	308.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2TQJS@28211|Alphaproteobacteria,3JUYV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Acyl-CoA dehydrogenase N terminal	MA20_19860	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N
k59_756044_1	371042.NG99_13125	2.52e-14	74.3	COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,1RR3Z@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	caiD	GO:0003674,GO:0003824,GO:0004300,GO:0006082,GO:0006575,GO:0006577,GO:0006579,GO:0006629,GO:0006631,GO:0006635,GO:0006807,GO:0008150,GO:0008152,GO:0008809,GO:0009056,GO:0009062,GO:0009437,GO:0009987,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0016856,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0034641,GO:0042219,GO:0042413,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044270,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:0097164,GO:1901564,GO:1901565,GO:1901575	4.2.1.149	ko:K08299	-	-	R10675	RC01095	ko00000,ko01000	-	-	iAPECO1_1312.APECO1_1945,iEC042_1314.EC042_0038,iECABU_c1320.ECABU_c00410,iECB_1328.ECB_00040,iECD_1391.ECD_00040,iECO103_1326.ECO103_0038,iECP_1309.ECP_0036,iETEC_1333.ETEC_0036,iNRG857_1313.NRG857_00190,iUMN146_1321.UM146_22960,ic_1306.c0045	ECH_1
k59_1368094_1	1121364.ATVG01000003_gene1552	9.1e-20	84.0	COG0256@1|root,COG0256@2|Bacteria,2IKTX@201174|Actinobacteria,22N5D@1653|Corynebacteriaceae	201174|Actinobacteria	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0008150,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
k59_1368094_2	379066.GAU_0890	1.83e-67	214.0	COG0098@1|root,COG0098@2|Bacteria,1ZTHD@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	-	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
k59_200870_2	224324.aq_1898	4.01e-44	152.0	COG0190@1|root,COG0190@2|Bacteria,2G3VE@200783|Aquificae	200783|Aquificae	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
k59_314374_1	331869.BAL199_24984	1.84e-58	194.0	COG0765@1|root,COG0765@2|Bacteria,1MV3I@1224|Proteobacteria,2TR9C@28211|Alphaproteobacteria,4BPRV@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	P	TIGRFAM amine acid ABC transporter, permease protein, 3-TM region, His Glu Gln Arg opine family	-	-	-	ko:K09971	ko02010,map02010	M00232	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	BPD_transp_1
k59_314374_2	1207076.ALAT01000019_gene837	0.000527	42.7	COG1126@1|root,COG1126@2|Bacteria,1MU9Q@1224|Proteobacteria,1RMX1@1236|Gammaproteobacteria,1Z1UK@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	E	COG1126 ABC-type polar amino acid transport system, ATPase component	yhdZ	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363	3.6.3.21	ko:K02028,ko:K02029,ko:K09972	ko02010,map02010	M00232,M00236	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3,3.A.1.3.17,3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	iJN746.PP_1300	ABC_tran
k59_314375_1	926550.CLDAP_40150	2.39e-39	147.0	COG1164@1|root,COG1164@2|Bacteria,2G5UV@200795|Chloroflexi	200795|Chloroflexi	E	PFAM peptidase M3A and M3B, thimet oligopeptidase F	-	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
k59_1202843_2	1297742.A176_01978	4.1e-22	94.7	COG0596@1|root,COG0596@2|Bacteria,1R4N4@1224|Proteobacteria,434SV@68525|delta/epsilon subdivisions,2WZ3Y@28221|Deltaproteobacteria,2Z19T@29|Myxococcales	28221|Deltaproteobacteria	S	Hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
k59_1370128_1	926569.ANT_06290	4.29e-138	397.0	COG0451@1|root,COG0451@2|Bacteria,2G7M6@200795|Chloroflexi	200795|Chloroflexi	GM	Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction	fcl	-	1.1.1.271	ko:K02377	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R05692	RC01014	ko00000,ko00001,ko01000	-	-	-	Epimerase
k59_1536047_1	324602.Caur_1753	7.68e-31	124.0	COG1574@1|root,COG1574@2|Bacteria,2G5YJ@200795|Chloroflexi,375CQ@32061|Chloroflexia	32061|Chloroflexia	S	PFAM Amidohydrolase 3	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_1370140_1	243090.RB981	1.83e-17	86.3	COG1228@1|root,COG1228@2|Bacteria,2IYFS@203682|Planctomycetes	203682|Planctomycetes	Q	COG1228 Imidazolonepropionase and related	-	-	3.5.1.25	ko:K01443	ko00520,ko01130,map00520,map01130	-	R02059	RC00166,RC00300	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
k59_145746_1	177437.HRM2_36780	1.77e-73	239.0	COG1321@1|root,COG1321@2|Bacteria,1N8WG@1224|Proteobacteria	1224|Proteobacteria	K	iron dependent repressor	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_424492_1	1220582.RRU01S_07_03530	2.36e-33	133.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,4B72Y@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Diguanylate cyclase	-	GO:0000302,GO:0003674,GO:0003824,GO:0006950,GO:0006979,GO:0008081,GO:0008150,GO:0009987,GO:0010035,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042578,GO:0050896,GO:0051716,GO:0052621,GO:0070887,GO:0071111,GO:0071241,GO:0071731,GO:0071732,GO:0097366,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,MHYT,PAS,PAS_8,PAS_9
k59_1148338_1	1191523.MROS_2036	4.36e-88	279.0	COG0668@1|root,COG0668@2|Bacteria	2|Bacteria	M	transmembrane transport	mscM	-	-	-	-	-	-	-	-	-	-	-	MS_channel
k59_200912_1	926569.ANT_01020	7.45e-34	127.0	COG3464@1|root,COG3464@2|Bacteria,2G9B1@200795|Chloroflexi	200795|Chloroflexi	L	Transposase IS66 family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66
k59_703540_1	1366050.N234_18005	8.03e-47	156.0	COG0757@1|root,COG0757@2|Bacteria,1RDDT@1224|Proteobacteria,2VR4Y@28216|Betaproteobacteria,1K5S0@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Catalyzes a trans-dehydration via an enolate intermediate	aroQ	-	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
k59_927510_2	316274.Haur_2192	4.55e-10	62.0	COG5295@1|root,COG5295@2|Bacteria,2GB82@200795|Chloroflexi,377IZ@32061|Chloroflexia	32061|Chloroflexia	UW	Hep Hag repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Pectinesterase
k59_927515_1	1009370.ALO_11549	8.77e-14	71.2	COG0557@1|root,COG0557@2|Bacteria,1TQ1G@1239|Firmicutes,4H23F@909932|Negativicutes	909932|Negativicutes	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
k59_813790_1	1569209.BBPH01000032_gene2768	4.55e-42	149.0	COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,2TR5B@28211|Alphaproteobacteria,2PV3W@265|Paracoccus	28211|Alphaproteobacteria	S	Peptidase dimerisation domain	MA20_09240	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
k59_813790_2	1041146.ATZB01000009_gene3430	0.000142	43.5	2ACW2@1|root,312HB@2|Bacteria,1PQQQ@1224|Proteobacteria,2V32Y@28211|Alphaproteobacteria,4BK2F@82115|Rhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1592594_1	1198114.AciX9_3601	4.86e-11	66.6	2EKX6@1|root,33EKQ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1645762_1	981085.XP_010093308.1	2.07e-16	82.4	COG1814@1|root,KOG4473@2759|Eukaryota,37TBU@33090|Viridiplantae,3GF43@35493|Streptophyta,4JHFD@91835|fabids	35493|Streptophyta	S	Vacuolar iron transporter	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
k59_1592595_2	706587.Desti_0819	2.37e-28	119.0	COG5000@1|root,COG5000@2|Bacteria,1NU7E@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	zraS	-	2.7.13.3	ko:K02668,ko:K07709,ko:K07710	ko02020,map02020	M00499,M00500,M00501	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9,sCache_3_2
k59_1425258_1	675813.VIB_002946	6.93e-15	75.9	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,1RQP7@1236|Gammaproteobacteria,1XVS8@135623|Vibrionales	135623|Vibrionales	L	Group II intron, maturase-specific domain	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k59_1425258_2	1218084.BBJK01000003_gene475	3.27e-06	49.3	2E8II@1|root,332WK@2|Bacteria,1RAN8@1224|Proteobacteria,2W705@28216|Betaproteobacteria,1K7IB@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1315668_1	1239962.C943_00057	1.03e-14	75.1	COG4191@1|root,COG4191@2|Bacteria,4NEJX@976|Bacteroidetes,47U6P@768503|Cytophagia	976|Bacteroidetes	T	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,SnoaL_3
k59_145783_1	744979.R2A130_3197	6.05e-57	186.0	COG0220@1|root,COG0220@2|Bacteria,1MUWJ@1224|Proteobacteria,2TUU9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	trmB	GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234	2.1.1.33	ko:K03439	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_4
k59_35008_1	1047013.AQSP01000076_gene1477	5.61e-13	69.7	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_1425262_1	29581.BW37_01674	8.07e-70	223.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,2VIT6@28216|Betaproteobacteria,472YH@75682|Oxalobacteraceae	28216|Betaproteobacteria	IQ	Belongs to the beta-ketoacyl-ACP synthases family	fabF2	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_200933_1	1463887.KL590007_gene2460	2.76e-10	59.3	COG2114@1|root,COG2114@2|Bacteria,2IQEQ@201174|Actinobacteria	201174|Actinobacteria	T	Protein of unknown function (DUF4242)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4242
k59_145791_1	414684.RC1_2561	1.28e-88	272.0	COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,2TR87@28211|Alphaproteobacteria,2JPNV@204441|Rhodospirillales	204441|Rhodospirillales	J	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
k59_35011_1	886293.Sinac_5362	9.34e-30	122.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2IXQR@203682|Planctomycetes	203682|Planctomycetes	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_1370216_1	1379270.AUXF01000001_gene1869	1.28e-16	85.9	COG1629@1|root,COG1629@2|Bacteria,1ZTI4@142182|Gemmatimonadetes	142182|Gemmatimonadetes	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
k59_868507_1	316274.Haur_1208	1.89e-15	75.1	COG0179@1|root,COG0179@2|Bacteria,2G7MW@200795|Chloroflexi,375D5@32061|Chloroflexia	32061|Chloroflexia	Q	PFAM fumarylacetoacetate (FAA) hydrolase	-	-	3.7.1.2	ko:K16171	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R01364	RC00326,RC00446	ko00000,ko00001,ko00002,ko01000	-	-	-	FAA_hydrolase
k59_868507_2	373994.Riv7116_3109	2.14e-06	49.7	COG1225@1|root,COG1225@2|Bacteria,1G2SK@1117|Cyanobacteria,1HJ2Z@1161|Nostocales	1117|Cyanobacteria	O	PFAM AhpC TSA family	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
k59_1092254_1	552811.Dehly_0557	6.71e-72	233.0	COG0308@1|root,COG0308@2|Bacteria,2G6SD@200795|Chloroflexi,34D27@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Peptidase MA superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_MA_2
k59_35030_1	1037409.BJ6T_79160	7.03e-11	63.5	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQMJ@28211|Alphaproteobacteria,3JRKH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	-	-	3.6.3.30	ko:K02010,ko:K02049,ko:K02052,ko:K11080	ko02010,ko02024,map02010,map02024	M00188,M00190,M00193,M00301	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10,3.A.1.11,3.A.1.11.3,3.A.1.16,3.A.1.17	-	-	ABC_tran,TOBE_2
k59_35030_2	485913.Krac_7969	5.19e-23	99.0	COG4992@1|root,COG4992@2|Bacteria	2|Bacteria	E	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity	patA	-	2.6.1.11,2.6.1.17,2.6.1.82	ko:K00821,ko:K05830,ko:K09251	ko00220,ko00300,ko00330,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map00330,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00031,M00763,M00845	R01155,R02283,R04475,R09778,R10932	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_368666_1	1304874.JAFY01000002_gene135	1.15e-62	204.0	COG0601@1|root,COG0601@2|Bacteria,3TAG1@508458|Synergistetes	508458|Synergistetes	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_758125_1	179408.Osc7112_6205	7.18e-66	202.0	COG0229@1|root,COG0229@2|Bacteria,1G5S6@1117|Cyanobacteria,1HB1V@1150|Oscillatoriales	1117|Cyanobacteria	O	Belongs to the MsrB Met sulfoxide reductase family	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
k59_813829_1	1047013.AQSP01000139_gene2352	5.06e-16	83.2	COG2866@1|root,COG2866@2|Bacteria	2|Bacteria	E	metallocarboxypeptidase activity	-	-	-	ko:K14054	-	-	-	-	ko00000	-	-	-	AstE_AspA,Peptidase_M14
k59_35036_1	649747.HMPREF0083_01708	9.87e-13	75.1	2DBYN@1|root,2ZBWH@2|Bacteria,1VJIJ@1239|Firmicutes,4HPX6@91061|Bacilli,26S7M@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_200959_1	985054.JQEZ01000002_gene3492	4.29e-42	156.0	COG0464@1|root,COG0464@2|Bacteria,1MXFG@1224|Proteobacteria,2TTA9@28211|Alphaproteobacteria,4NA1M@97050|Ruegeria	28211|Alphaproteobacteria	O	ATPase with chaperone activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_813830_1	994479.GL877887_gene7093	6.07e-15	76.3	COG4585@1|root,COG4585@2|Bacteria,2GKV2@201174|Actinobacteria,4DZQM@85010|Pseudonocardiales	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
k59_813830_2	1172181.KB911699_gene1397	1.71e-45	154.0	COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria	201174|Actinobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_1038593_1	1177154.Y5S_00554	4.55e-56	187.0	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,1RPB4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	ABC-type multidrug transport system, permease component	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane,ABC2_membrane_3
k59_1370274_1	671143.DAMO_0966	3.75e-54	182.0	COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,2NPE1@2323|unclassified Bacteria	2|Bacteria	S	Peptidase family M50	spoIVFB	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K06212,ko:K06402	-	-	-	-	ko00000,ko01000,ko01002,ko02000	1.A.16.1.1,1.A.16.1.3	-	-	CBS,Form_Nir_trans,Peptidase_M50
k59_1606713_1	1340493.JNIF01000003_gene3814	5.18e-36	136.0	COG3391@1|root,COG3391@2|Bacteria,3Y99Z@57723|Acidobacteria	57723|Acidobacteria	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	TIG
k59_658873_1	203119.Cthe_1346	1.49e-46	170.0	COG0608@1|root,COG0608@2|Bacteria,1TPXE@1239|Firmicutes,247NU@186801|Clostridia,3WI09@541000|Ruminococcaceae	186801|Clostridia	L	exonuclease	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1,ssDNA-exonuc_C
k59_1106957_1	926569.ANT_03930	2.92e-26	105.0	COG1045@1|root,COG1045@2|Bacteria,2G6DI@200795|Chloroflexi	200795|Chloroflexi	E	TIGRFAM serine O-acetyltransferase	cysE	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
k59_942417_1	1096930.L284_11780	9.2e-42	157.0	COG3321@1|root,COG3321@2|Bacteria,1R89Z@1224|Proteobacteria,2UR2U@28211|Alphaproteobacteria,2K1SP@204457|Sphingomonadales	204457|Sphingomonadales	Q	Ketoacyl-synthetase C-terminal extension	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,Thioesterase,ketoacyl-synt
k59_884468_1	1232410.KI421428_gene970	1.02e-26	108.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,42MMK@68525|delta/epsilon subdivisions,2WJC1@28221|Deltaproteobacteria,43RZT@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	ABC transporter	yjjK	-	3.6.3.25	ko:K06020	-	-	-	-	ko00000,ko01000	-	-	-	ABC_tran,ABC_tran_Xtn
k59_884469_1	861299.J421_2529	6.98e-17	80.5	COG0568@1|root,COG0568@2|Bacteria,1ZSNB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_105231_1	1144310.PMI07_000822	2.08e-28	118.0	COG0419@1|root,COG0419@2|Bacteria,1RC5M@1224|Proteobacteria,2U63G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_23
k59_1772390_1	1232410.KI421421_gene3270	7.44e-35	133.0	COG1775@1|root,COG1775@2|Bacteria,1NNW9@1224|Proteobacteria,42RTN@68525|delta/epsilon subdivisions,2WNYI@28221|Deltaproteobacteria,43V0Q@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	2-hydroxyglutaryl-CoA dehydratase, D-component	-	-	1.3.7.8	ko:K04112	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R02451	RC00002,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	HGD-D
k59_1606734_1	269482.Bcep1808_0276	3.8e-48	169.0	COG3328@1|root,COG3328@2|Bacteria,1R81T@1224|Proteobacteria,2W75T@28216|Betaproteobacteria,1KDWC@119060|Burkholderiaceae	28216|Betaproteobacteria	L	PFAM transposase, mutator type	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_438815_1	518766.Rmar_0226	1.83e-27	115.0	COG5557@1|root,COG5557@2|Bacteria,4PKRP@976|Bacteroidetes,1FIRC@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	C	Quinol cytochrome C oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1106977_1	400682.PAC_15710332	2.91e-59	206.0	COG1132@1|root,KOG0055@2759|Eukaryota,39YRK@33154|Opisthokonta,3BN4Z@33208|Metazoa	33208|Metazoa	Q	atp-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,oligo_HPY
k59_1718592_1	1379270.AUXF01000004_gene2871	8.2e-08	59.3	COG5492@1|root,COG5492@2|Bacteria,1ZUE7@142182|Gemmatimonadetes	142182|Gemmatimonadetes	N	Bacterial Ig-like domain 2	-	-	-	-	-	-	-	-	-	-	-	-	Big_2
k59_828152_1	1469245.JFBG01000037_gene1849	1.04e-42	159.0	COG3276@1|root,COG3276@2|Bacteria,1MWXH@1224|Proteobacteria,1RQJI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Translation elongation factor	selB	GO:0000049,GO:0000166,GO:0001514,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006412,GO:0006414,GO:0006417,GO:0006451,GO:0006518,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009069,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016259,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031326,GO:0032268,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034248,GO:0034641,GO:0034645,GO:0035368,GO:0035639,GO:0036094,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:2000112	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3
k59_105256_1	1122221.JHVI01000001_gene1886	2.56e-64	212.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1WICK@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH,NMO
k59_1108882_1	1121272.KB903290_gene4687	6.33e-32	127.0	COG0842@1|root,COG0842@2|Bacteria,2IART@201174|Actinobacteria	201174|Actinobacteria	V	ABC-type multidrug transport system, permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_3
k59_215324_1	1499967.BAYZ01000029_gene1222	1.01e-40	151.0	COG1032@1|root,COG5011@1|root,COG1032@2|Bacteria,COG5011@2|Bacteria,2NNKI@2323|unclassified Bacteria	2|Bacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	DUF2344,Radical_SAM
k59_1608641_1	518766.Rmar_2616	3e-64	214.0	COG1472@1|root,COG1472@2|Bacteria,4NE90@976|Bacteroidetes,1FIS9@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	G	PFAM glycoside hydrolase family 3 domain protein	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
k59_1774796_1	314256.OG2516_00100	3.68e-58	202.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,1MVWY@1224|Proteobacteria,2TRSZ@28211|Alphaproteobacteria,2PCIX@252301|Oceanicola	28211|Alphaproteobacteria	L	COG1793 ATP-dependent DNA ligase	ligD	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
k59_1662381_1	1000565.METUNv1_03264	4.26e-65	209.0	COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,2VIG0@28216|Betaproteobacteria,2KU8M@206389|Rhodocyclales	206389|Rhodocyclales	K	Belongs to the ParB family	spoOJ	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
k59_1333755_1	865937.Gilli_1605	2.66e-14	75.1	COG1011@1|root,COG1011@2|Bacteria,4NM66@976|Bacteroidetes,1I188@117743|Flavobacteriia,2P5G7@244698|Gillisia	976|Bacteroidetes	S	HAD-hyrolase-like	yjjG	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
k59_1054612_1	1121920.AUAU01000016_gene1364	1.75e-41	142.0	COG1881@1|root,COG1881@2|Bacteria,3Y5UH@57723|Acidobacteria	57723|Acidobacteria	S	Phosphatidylethanolamine-binding protein	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
k59_162819_1	1123368.AUIS01000003_gene1728	4.63e-57	190.0	COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,1RPQ7@1236|Gammaproteobacteria,2NBTG@225057|Acidithiobacillales	225057|Acidithiobacillales	I	glycerol-3-phosphate metabolic process	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
k59_499813_1	648757.Rvan_2148	4.45e-09	63.5	COG0726@1|root,COG1215@1|root,COG3858@1|root,COG0726@2|Bacteria,COG1215@2|Bacteria,COG3858@2|Bacteria,1MXG7@1224|Proteobacteria,2TVZ5@28211|Alphaproteobacteria,3N8XE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Glycosyl transferase family group 2	-	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_hydro_18,Glyco_tranf_2_3,Polysacc_deac_1
k59_162831_1	234267.Acid_4508	1.36e-111	346.0	COG3408@1|root,COG3408@2|Bacteria	2|Bacteria	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_63
k59_830099_1	405948.SACE_7306	3.85e-08	53.5	COG0640@1|root,COG0640@2|Bacteria,2IKQY@201174|Actinobacteria,4E4CZ@85010|Pseudonocardiales	201174|Actinobacteria	K	transcriptional regulator, ArsR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
k59_830099_2	258533.BN977_04862	1.52e-26	103.0	COG3832@1|root,COG3832@2|Bacteria,2ISCU@201174|Actinobacteria,23992@1762|Mycobacteriaceae	201174|Actinobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
k59_1218353_1	1121272.KB903289_gene4129	9.98e-67	225.0	2DBMZ@1|root,2ZA12@2|Bacteria,2IIKK@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_215368_1	391625.PPSIR1_18075	4.6e-89	285.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,42MER@68525|delta/epsilon subdivisions,2WIYV@28221|Deltaproteobacteria,2YW7P@29|Myxococcales	28221|Deltaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_1608693_1	246197.MXAN_4895	1.92e-90	281.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,42M52@68525|delta/epsilon subdivisions,2WIRK@28221|Deltaproteobacteria,2YUQN@29|Myxococcales	28221|Deltaproteobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
k59_1166305_1	671143.DAMO_1933	3.71e-67	229.0	COG0841@1|root,COG0841@2|Bacteria,2NNUH@2323|unclassified Bacteria	2|Bacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_887040_1	1122951.ATUE01000007_gene613	4.64e-25	102.0	COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,1RQ1J@1236|Gammaproteobacteria,3NJJT@468|Moraxellaceae	1236|Gammaproteobacteria	K	response regulator	sirA	-	-	ko:K07689	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	M00475	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
k59_773065_1	1112204.GPOL_c15210	3.89e-07	59.3	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,2GMN4@201174|Actinobacteria,4GD0M@85026|Gordoniaceae	201174|Actinobacteria	GT	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
k59_499867_1	631454.N177_3446	1.86e-19	92.4	COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,2TTJZ@28211|Alphaproteobacteria,1JPYA@119043|Rhodobiaceae	28211|Alphaproteobacteria	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_721654_1	1280953.HOC_17030	4.95e-82	257.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2TQKF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG4584 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_660881_2	926569.ANT_29900	3.36e-16	79.0	COG4012@1|root,COG4012@2|Bacteria,2G6IF@200795|Chloroflexi	200795|Chloroflexi	S	Putative pyruvate format-lyase activating enzyme (DUF1786)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1786
k59_887087_1	96561.Dole_0673	6.53e-50	179.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,42KZ9@68525|delta/epsilon subdivisions,2WJBC@28221|Deltaproteobacteria,2MIKT@213118|Desulfobacterales	28221|Deltaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_721677_1	1121033.AUCF01000013_gene1609	6.01e-46	161.0	COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,2TRSR@28211|Alphaproteobacteria,2JPFJ@204441|Rhodospirillales	204441|Rhodospirillales	S	peptidase U62, modulator of DNA gyrase	tldD	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
k59_1662468_1	631362.Thi970DRAFT_04397	8.8e-68	223.0	COG0055@1|root,COG0055@2|Bacteria,1N6UZ@1224|Proteobacteria,1RNQW@1236|Gammaproteobacteria,1X06F@135613|Chromatiales	135613|Chromatiales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	-	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_1166370_1	1472716.KBK24_0134235	2.9e-71	226.0	COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,2VHJJ@28216|Betaproteobacteria,1K2ZR@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
k59_605679_1	1289387.AUKW01000003_gene2596	2.23e-18	86.3	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31
k59_830211_1	1122921.KB898186_gene5178	1.87e-59	197.0	COG1304@1|root,COG1304@2|Bacteria,1TQZ3@1239|Firmicutes,4HAMV@91061|Bacilli,26QKA@186822|Paenibacillaceae	91061|Bacilli	C	Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)	fni	GO:0003674,GO:0003824,GO:0004452,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016853,GO:0016860,GO:0016863,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0071704,GO:1901576	5.3.3.2	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123	RC00455	ko00000,ko00001,ko00002,ko01000	-	-	-	FMN_dh
k59_1608771_1	44060.JODL01000043_gene3966	2.22e-182	529.0	COG1028@1|root,COG3347@1|root,COG1028@2|Bacteria,COG3347@2|Bacteria,2GNEI@201174|Actinobacteria	201174|Actinobacteria	IQ	Rhamnulose-1-phosphate aldolase alcohol dehydrogenase	rhaD	-	1.1.1.1,1.1.1.140,4.1.2.19	ko:K00001,ko:K00068,ko:K01629	ko00010,ko00040,ko00051,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00040,map00051,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R01785,R02124,R02263,R04805,R04880,R05233,R05234,R05607,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00085,RC00087,RC00088,RC00099,RC00116,RC00438,RC00599,RC00603,RC00604,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	Aldolase_II,adh_short_C2
k59_773114_1	204669.Acid345_0466	2.7e-93	305.0	COG0508@1|root,COG4770@1|root,COG4799@1|root,COG0508@2|Bacteria,COG4770@2|Bacteria,COG4799@2|Bacteria	2|Bacteria	I	CoA carboxylase activity	-	-	2.1.3.1,2.1.3.15,2.3.1.12,3.2.1.1,6.4.1.3	ko:K00627,ko:K01176,ko:K01966,ko:K03646,ko:K17489	ko00010,ko00020,ko00280,ko00500,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04973,map00010,map00020,map00280,map00500,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map04973	M00307,M00373,M00741	R00209,R00353,R01859,R02108,R02112,R02569,R11262	RC00004,RC00040,RC00097,RC00609,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000,ko02000	2.C.1.2	GH13	-	ACC_central,Alpha-amylase,Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CBM_48,CPSase_L_D2,Carboxyl_trans,DUF349,Gram_pos_anchor,PUD,YSIRK_signal
k59_605683_1	644282.Deba_0241	5.04e-86	276.0	COG0369@1|root,COG1151@2|Bacteria,1NYH2@1224|Proteobacteria,42NE1@68525|delta/epsilon subdivisions,2WIVX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	TIGRFAM Carbon-monoxide dehydrogenase, catalytic subunit	-	-	1.2.7.4	ko:K00198	ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200	M00377	R07157,R08034	RC00250,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Prismane
k59_944860_1	545264.KB898746_gene912	6.48e-12	66.6	COG1622@1|root,COG1622@2|Bacteria,1RHZD@1224|Proteobacteria,1T0EG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Cytochrome C oxidase subunit II, periplasmic domain	-	-	-	-	-	-	-	-	-	-	-	-	COX2
k59_441030_1	1379270.AUXF01000006_gene286	8.7e-63	207.0	COG1160@1|root,COG1160@2|Bacteria,1ZSQY@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
k59_441048_1	381666.H16_B1740	1.03e-13	75.5	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VM40@28216|Betaproteobacteria,1KGIX@119060|Burkholderiaceae	28216|Betaproteobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_1333922_1	1385517.N800_00205	1.65e-23	105.0	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,1X3D1@135614|Xanthomonadales	135614|Xanthomonadales	E	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
k59_551368_1	107636.JQNK01000009_gene3513	2.87e-63	207.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2TRXG@28211|Alphaproteobacteria,370BU@31993|Methylocystaceae	28211|Alphaproteobacteria	L	Transposase DDE domain	-	-	-	ko:K07487	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_1774981_1	1295642.H839_14982	1.54e-20	93.6	COG1231@1|root,COG1231@2|Bacteria,1TRJC@1239|Firmicutes,4HBN4@91061|Bacilli,1WFVQ@129337|Geobacillus	91061|Bacilli	E	Flavin containing amine oxidoreductase	iaaM	-	1.4.3.4	ko:K00274	ko00260,ko00330,ko00340,ko00350,ko00360,ko00380,ko00950,ko00982,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00260,map00330,map00340,map00350,map00360,map00380,map00950,map00982,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00135	R02173,R02382,R02529,R02532,R02613,R02908,R02919,R04025,R04300,R04674,R04890,R04893,R04894,R04907,R04908,R08346,R08347,R08348,R11354	RC00062,RC00160,RC00225,RC00676,RC00807,RC00808,RC01808,RC02226,RC02713	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
k59_773141_1	861299.J421_2948	1.55e-23	100.0	COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria,1ZSUS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	MU	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag,PD40
k59_773141_2	377629.TERTU_0601	3.2e-27	104.0	COG0799@1|root,COG0799@2|Bacteria,1MZEF@1224|Proteobacteria,1S8W3@1236|Gammaproteobacteria,2PNVF@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	J	Ribosomal silencing factor during starvation	rsfS	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006417,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043023,GO:0044087,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:0090069,GO:0090071,GO:2000112,GO:2000113	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
k59_1550638_1	1528106.JRJE01000031_gene3353	7.49e-37	132.0	COG0730@1|root,COG0730@2|Bacteria,1MVY3@1224|Proteobacteria,2TU6M@28211|Alphaproteobacteria,2JRRQ@204441|Rhodospirillales	204441|Rhodospirillales	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
k59_660965_1	278963.ATWD01000001_gene4073	8.91e-32	122.0	COG0412@1|root,COG0412@2|Bacteria,3Y3UQ@57723|Acidobacteria,2JIIB@204432|Acidobacteriia	204432|Acidobacteriia	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
k59_997561_1	926550.CLDAP_00290	4.32e-108	326.0	COG1070@1|root,COG1070@2|Bacteria,2G5QX@200795|Chloroflexi	200795|Chloroflexi	G	PFAM carbohydrate kinase	xylB	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
k59_1550646_1	580340.Tlie_1891	2.49e-53	184.0	COG3328@1|root,COG3328@2|Bacteria,3TAQX@508458|Synergistetes	508458|Synergistetes	L	PFAM Transposase, Mutator family	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_1441977_1	1125863.JAFN01000001_gene1650	1.33e-110	334.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WJ88@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	two component, sigma54 specific, transcriptional regulator, Fis family	ntrX	-	-	ko:K13599	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_944925_1	266117.Rxyl_0053	1.46e-28	112.0	COG0363@1|root,COG0363@2|Bacteria,2GMQ2@201174|Actinobacteria,4CQA7@84995|Rubrobacteria	84995|Rubrobacteria	G	Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase	-	-	3.1.1.31	ko:K01057	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
k59_1775022_1	269799.Gmet_1810	7.89e-40	150.0	COG0243@1|root,COG0243@2|Bacteria,1R4RR@1224|Proteobacteria,42PA5@68525|delta/epsilon subdivisions,2WM0K@28221|Deltaproteobacteria,43W1I@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	qrcB	-	-	ko:K08357	ko00920,ko01120,ko02020,map00920,map01120,map02020	-	R10150	RC03109	ko00000,ko00001,ko02000	5.A.3.10	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_1166467_1	1232447.BAHW02000010_gene480	1.98e-25	112.0	COG0841@1|root,COG0841@2|Bacteria,1TQ03@1239|Firmicutes,2491S@186801|Clostridia,26893@186813|unclassified Clostridiales	186801|Clostridia	V	AcrB/AcrD/AcrF family	czcA	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_500013_1	663610.JQKO01000006_gene2541	2.06e-64	208.0	COG4973@1|root,COG4973@2|Bacteria,1MUJJ@1224|Proteobacteria,2TVZJ@28211|Alphaproteobacteria,3ND1D@45404|Beijerinckiaceae	28211|Alphaproteobacteria	L	Phage integrase, N-terminal SAM-like domain	xerC	-	-	ko:K03733	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_661017_1	391615.ABSJ01000043_gene2314	5.98e-23	102.0	COG0341@1|root,COG0342@1|root,COG0341@2|Bacteria,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,1RMIQ@1236|Gammaproteobacteria,1J4DW@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD-TM1,SecD_SecF,Sec_GG
k59_1218493_1	1379270.AUXF01000002_gene1195	2.55e-65	206.0	COG0461@1|root,COG0461@2|Bacteria,1ZTMR@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
k59_1608869_1	224911.27354662	1.52e-37	140.0	COG1414@1|root,COG1414@2|Bacteria,1RDS5@1224|Proteobacteria,2TVQ4@28211|Alphaproteobacteria,3JX49@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	Bacterial transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
k59_887231_1	869213.JCM21142_31341	8.42e-48	173.0	COG2146@1|root,COG2871@1|root,COG3239@1|root,COG2146@2|Bacteria,COG2871@2|Bacteria,COG3239@2|Bacteria,4NFKC@976|Bacteroidetes,47NPF@768503|Cytophagia	976|Bacteroidetes	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway	-	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase,NAD_binding_1,Rieske
k59_898110_1	1037409.BJ6T_61420	9.38e-31	120.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
k59_898128_1	1234595.C725_1658	2.56e-50	171.0	COG0498@1|root,COG0498@2|Bacteria,1R7X1@1224|Proteobacteria,2TUR3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Threonine synthase	MA20_41710	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_1342480_1	89187.ISM_08020	0.000225	42.7	COG0583@1|root,COG0583@2|Bacteria,1PX1B@1224|Proteobacteria,2TUE7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Transcriptional regulator, LysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_1342480_2	215803.DB30_6366	2.38e-38	140.0	COG0583@1|root,COG0583@2|Bacteria,1MWVB@1224|Proteobacteria,42U9X@68525|delta/epsilon subdivisions,2WQN5@28221|Deltaproteobacteria,2YXWV@29|Myxococcales	28221|Deltaproteobacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_508623_1	394221.Mmar10_0676	1.27e-17	80.5	COG2834@1|root,COG2834@2|Bacteria,1MXW0@1224|Proteobacteria,2U3UR@28211|Alphaproteobacteria,43ZDW@69657|Hyphomonadaceae	28211|Alphaproteobacteria	M	Outer membrane lipoprotein-sorting protein	-	-	-	-	-	-	-	-	-	-	-	-	LolA_like
k59_508623_2	1122137.AQXF01000005_gene1237	1.33e-36	137.0	28I6N@1|root,2Z89J@2|Bacteria,1MUVT@1224|Proteobacteria,2TUAV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1454070_1	638303.Thal_0931	4.49e-08	59.7	COG0330@1|root,COG0330@2|Bacteria,2G4JQ@200783|Aquificae	200783|Aquificae	O	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
k59_341622_1	402777.KB235904_gene3192	9.14e-59	205.0	COG0642@1|root,COG2199@1|root,COG3290@1|root,COG2205@2|Bacteria,COG3290@2|Bacteria,COG3706@2|Bacteria,1G13T@1117|Cyanobacteria,1H77Q@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_8,PAS_9,Response_reg
k59_176603_1	1380391.JIAS01000011_gene5348	4.63e-55	182.0	COG1354@1|root,COG1354@2|Bacteria,1MVCN@1224|Proteobacteria,2TS1V@28211|Alphaproteobacteria,2JR8P@204441|Rhodospirillales	204441|Rhodospirillales	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
k59_677382_1	991905.SL003B_4075	1.82e-46	162.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria	1224|Proteobacteria	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_38,HTH_7,rve
k59_1677704_1	926569.ANT_05670	7.53e-103	310.0	COG0074@1|root,COG0074@2|Bacteria,2G7UI@200795|Chloroflexi	200795|Chloroflexi	C	Protein of unknown function (DUF1116)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1116
k59_1344079_2	558173.CDOO_09285	7.57e-09	59.3	COG0620@1|root,COG0620@2|Bacteria,2H8H4@201174|Actinobacteria,22K3I@1653|Corynebacteriaceae	201174|Actinobacteria	E	Methionine synthase II (cobalamin-independent)	metE2	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
k59_1288572_1	1296990.H845_1202	1.45e-13	74.7	COG3191@1|root,COG3191@2|Bacteria,1MWDP@1224|Proteobacteria,2TRDC@28211|Alphaproteobacteria,2JQ8G@204441|Rhodospirillales	204441|Rhodospirillales	EQ	Peptidase family S58	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S58
k59_1288572_2	1123242.JH636434_gene5426	1.39e-09	59.3	COG0546@1|root,COG0546@2|Bacteria,2IZQM@203682|Planctomycetes	203682|Planctomycetes	S	haloacid dehalogenase-like hydrolase	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD,HAD_2
k59_1288577_1	439235.Dalk_1727	6.45e-15	79.7	COG2079@1|root,COG2079@2|Bacteria,1NECN@1224|Proteobacteria,43B26@68525|delta/epsilon subdivisions,2X6G6@28221|Deltaproteobacteria,2MKC2@213118|Desulfobacterales	28221|Deltaproteobacteria	S	MmgE/PrpD family	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
k59_565699_1	1410633.JHWR01000008_gene1712	4.65e-11	67.4	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1TNZE@1239|Firmicutes,2480H@186801|Clostridia,27J5F@186928|unclassified Lachnospiraceae	186801|Clostridia	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	ACPS,Carb_kinase,YjeF_N
k59_955010_1	1000565.METUNv1_02456	1.37e-51	180.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,2KURM@206389|Rhodocyclales	206389|Rhodocyclales	NU	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB	-	-	-	-	-	-	-	-	-	-	-	-	GAF,T2SSE,T2SSE_N
k59_955010_2	365046.Rta_37350	2.96e-27	109.0	COG2203@1|root,COG2804@1|root,COG2203@2|Bacteria,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,4ACRA@80864|Comamonadaceae	28216|Betaproteobacteria	NU	General secretory system II, protein E domain protein	-	-	-	ko:K02454,ko:K02652	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	GAF,T2SSE,T2SSE_N
k59_1399818_1	1301098.PKB_5289	1.72e-12	72.0	COG0235@1|root,COG0235@2|Bacteria,1MWP9@1224|Proteobacteria,1RQNI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II
k59_900007_1	909663.KI867150_gene946	4.48e-87	276.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1MU9U@1224|Proteobacteria,42N86@68525|delta/epsilon subdivisions,2WIV4@28221|Deltaproteobacteria,2MQXS@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.5.1	ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
k59_955020_1	1562701.BBOF01000087_gene648	1.58e-13	63.5	2EG3W@1|root,339VW@2|Bacteria,1NHIR@1224|Proteobacteria,2W5YQ@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1177534_1	1207063.P24_17382	1.01e-88	278.0	COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,2TR63@28211|Alphaproteobacteria,2JQ9U@204441|Rhodospirillales	204441|Rhodospirillales	T	GTP-binding protein TypA	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
k59_510268_1	1042377.AFPJ01000020_gene2080	9.87e-74	223.0	COG3631@1|root,COG3631@2|Bacteria	2|Bacteria	S	light absorption	-	-	2.5.1.18	ko:K00799,ko:K06893	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	Abhydrolase_1,Abhydrolase_4,Ank_2,Ank_4,ECH_1,FAD_binding_3,SnoaL_2,SnoaL_4
k59_1621852_1	1304275.C41B8_10615	6.43e-88	278.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	(ABC) transporter	ybhF	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006855,GO:0008150,GO:0015562,GO:0015893,GO:0016020,GO:0022857,GO:0042221,GO:0042493,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_65517_1	1267534.KB906758_gene2499	5.72e-174	499.0	COG0654@1|root,COG0654@2|Bacteria	2|Bacteria	CH	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases	-	-	1.14.13.127	ko:K05712	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06786,R06787	RC00236	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
k59_176672_1	694430.Natoc_3865	1.69e-05	53.1	COG1277@1|root,arCOG02438@2157|Archaea,2XVCX@28890|Euryarchaeota,23T94@183963|Halobacteria	183963|Halobacteria	S	ABC-type transport system involved in multi-copper enzyme maturation, permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
k59_1677767_1	530564.Psta_0724	1.31e-34	127.0	COG1994@1|root,COG1994@2|Bacteria,2J0CK@203682|Planctomycetes	203682|Planctomycetes	S	PFAM peptidase M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
k59_1677767_2	926569.ANT_16190	2.76e-94	285.0	COG0182@1|root,COG0182@2|Bacteria,2G5Z3@200795|Chloroflexi	200795|Chloroflexi	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
k59_1621863_1	272134.KB731324_gene4333	4.02e-14	73.2	COG0404@1|root,COG0404@2|Bacteria,1G0GR@1117|Cyanobacteria,1H70I@1150|Oscillatoriales	1117|Cyanobacteria	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
k59_1621863_2	1128421.JAGA01000002_gene1814	1.01e-34	124.0	COG0521@1|root,COG0521@2|Bacteria	2|Bacteria	H	Mo-molybdopterin cofactor metabolic process	mog	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019538,GO:0019637,GO:0019693,GO:0032324,GO:0034641,GO:0042278,GO:0042802,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0061598,GO:0070566,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657	2.7.7.75,2.8.1.12,4.99.1.12	ko:K03635,ko:K03831,ko:K09121	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395,R09726	RC00002,RC02507	ko00000,ko00001,ko01000	-	-	iAPECO1_1312.APECO1_1969,iECABU_c1320.ECABU_c00100,iECED1_1282.ECED1_0009,iECNA114_1301.ECNA114_4653,iECP_1309.ECP_0010,iECS88_1305.ECS88_0010,iECSF_1327.ECSF_0009,iECUMN_1333.ECUMN_0010,iEcSMS35_1347.EcSMS35_0008,iLF82_1304.LF82_1379,iNRG857_1313.NRG857_00050,iUMN146_1321.UM146_22820	MoCF_biosynth
k59_1566742_1	1385517.N800_00790	8.27e-35	121.0	2C19F@1|root,32TZS@2|Bacteria,1R3J6@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1733334_1	983544.Lacal_0500	7.54e-23	99.0	COG0500@1|root,COG2226@2|Bacteria,4NE6P@976|Bacteroidetes,1HXEZ@117743|Flavobacteriia	976|Bacteroidetes	Q	Methyltransferase	rebM	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_176690_1	1200792.AKYF01000027_gene336	2.67e-70	227.0	COG0141@1|root,COG0141@2|Bacteria,1TPAW@1239|Firmicutes,4H9XK@91061|Bacilli,26SZ9@186822|Paenibacillaceae	91061|Bacilli	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU34910	Histidinol_dh
k59_1399862_1	880073.Calab_0924	1.12e-06	55.8	COG1629@1|root,COG4771@2|Bacteria,2NP6Z@2323|unclassified Bacteria	2|Bacteria	P	COGs COG1629 Outer membrane receptor protein mostly Fe transport	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec
k59_1455870_1	1245469.S58_43130	6.88e-41	140.0	2CEM6@1|root,31A6G@2|Bacteria,1RA6S@1224|Proteobacteria,2U65M@28211|Alphaproteobacteria,3JY78@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1455870_2	765698.Mesci_0215	1.42e-09	58.9	COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,2TR28@28211|Alphaproteobacteria,43NDQ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ptsI	-	2.7.3.9	ko:K08483,ko:K11183	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	4.A.2.1,8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
k59_1122472_1	935557.ATYB01000009_gene734	3.39e-19	92.4	COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,4BBZJ@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_7,PAS_9
k59_1733343_1	1223542.GM1_011_00410	1.83e-17	84.7	COG3629@1|root,COG3899@1|root,COG3629@2|Bacteria,COG3899@2|Bacteria,2I2U4@201174|Actinobacteria,4GB84@85026|Gordoniaceae	201174|Actinobacteria	K	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,Trans_reg_C
k59_455032_1	459349.CLOAM0610	5.56e-21	97.1	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,2NP6Z@2323|unclassified Bacteria	2|Bacteria	P	COGs COG1629 Outer membrane receptor protein mostly Fe transport	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec
k59_621337_1	882378.RBRH_02086	2.92e-36	133.0	COG1024@1|root,COG1024@2|Bacteria,1Q67Q@1224|Proteobacteria,2VJC1@28216|Betaproteobacteria,1JZXT@119060|Burkholderiaceae	28216|Betaproteobacteria	I	enoyl-CoA hydratase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
k59_621337_2	1157637.KB892090_gene6579	3.4e-24	100.0	COG0596@1|root,COG0596@2|Bacteria,2GMMB@201174|Actinobacteria	201174|Actinobacteria	M	Alpha beta hydrolase	ephA	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
k59_900069_1	102107.XP_008239446.1	9.9e-65	213.0	COG0137@1|root,KOG1706@2759|Eukaryota,37QUX@33090|Viridiplantae,3G8Y6@35493|Streptophyta,4JEKX@91835|fabids	35493|Streptophyta	E	Argininosuccinate synthase	-	GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
k59_1344171_1	68219.JNXI01000002_gene3946	1.37e-74	242.0	COG0438@1|root,COG0438@2|Bacteria,2ICGI@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyl transferases group 1	-	-	2.4.1.245	ko:K13057	ko00500,ko01100,map00500,map01100	-	R08946,R10525,R11306	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000	-	GT4	-	Glycos_transf_1,YHS
k59_677515_1	255470.cbdbA547	5.91e-32	127.0	COG4166@1|root,COG4166@2|Bacteria,2G5TA@200795|Chloroflexi,34CV3@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
k59_343355_1	1379270.AUXF01000002_gene1585	5.47e-51	180.0	COG0515@1|root,COG0515@2|Bacteria,1ZUMJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
k59_1234313_1	62928.azo3324	3.23e-68	213.0	COG0512@1|root,COG0512@2|Bacteria,1MV5Y@1224|Proteobacteria,2VHGQ@28216|Betaproteobacteria,2KVJD@206389|Rhodocyclales	206389|Rhodocyclales	EH	anthranilate	trpG	-	4.1.3.27	ko:K01658	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
k59_955093_1	472759.Nhal_3785	2.6e-58	192.0	COG2008@1|root,COG2008@2|Bacteria,1MWCR@1224|Proteobacteria,1RNYX@1236|Gammaproteobacteria,1X0GH@135613|Chromatiales	135613|Chromatiales	E	Beta-eliminating lyase	-	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
k59_955093_2	765420.OSCT_2915	0.000234	48.5	COG0500@1|root,COG2226@2|Bacteria,2GA7Z@200795|Chloroflexi,375F2@32061|Chloroflexia	32061|Chloroflexia	Q	Methionine biosynthesis protein MetW	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
k59_343370_1	1270196.JCKI01000001_gene3788	3.63e-50	185.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,4NF70@976|Bacteroidetes,1IPE8@117747|Sphingobacteriia	976|Bacteroidetes	EU	Dipeptidyl peptidase IV (DPP IV) N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	DPPIV_N,PD40,Peptidase_S9
k59_1288699_1	349124.Hhal_1008	5.08e-75	247.0	COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,1RN9H@1236|Gammaproteobacteria,1WWAT@135613|Chromatiales	135613|Chromatiales	M	Catalyzes cross-linking of the peptidoglycan cell wall	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
k59_1621949_2	1403313.AXBR01000013_gene1424	1.3e-37	133.0	COG0822@1|root,COG0822@2|Bacteria,1V3H9@1239|Firmicutes,4HIJ0@91061|Bacilli,1ZFQ8@1386|Bacillus	91061|Bacilli	C	COG0822 NifU homolog involved in Fe-S cluster formation	nifU	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0010467,GO:0016740,GO:0016782,GO:0019538,GO:0019725,GO:0030003,GO:0036455,GO:0042592,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0046916,GO:0048037,GO:0048878,GO:0050801,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071704,GO:0097428,GO:0098771,GO:1901564	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
k59_900125_1	861299.J421_0812	1.63e-12	72.4	COG0612@1|root,COG0612@2|Bacteria,1ZT6X@142182|Gemmatimonadetes	2|Bacteria	S	Insulinase (Peptidase family M16)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_1177656_1	324057.Pjdr2_3406	3.19e-20	84.7	COG0858@1|root,COG0858@2|Bacteria,1VA0P@1239|Firmicutes,4HII1@91061|Bacilli,26YF0@186822|Paenibacillaceae	91061|Bacilli	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
k59_1177656_2	1158338.JNLJ01000001_gene108	8.95e-15	70.9	COG1550@1|root,COG1550@2|Bacteria,2G47V@200783|Aquificae	200783|Aquificae	S	Protein of unknown function (DUF503)	-	-	-	ko:K09764	-	-	-	-	ko00000	-	-	-	DUF503
k59_955146_1	926569.ANT_15740	8.96e-27	108.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_31
k59_1234364_2	1123278.KB893433_gene638	9.85e-75	232.0	COG0412@1|root,COG0412@2|Bacteria,4NEUX@976|Bacteroidetes,47JGG@768503|Cytophagia	976|Bacteroidetes	Q	dienelactone hydrolase	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
k59_510378_1	1217718.ALOU01000110_gene2928	8.28e-09	63.5	COG2801@1|root,COG2801@2|Bacteria,1N207@1224|Proteobacteria,2VRA9@28216|Betaproteobacteria,1K6DX@119060|Burkholderiaceae	28216|Betaproteobacteria	L	leucine-zipper of insertion element IS481	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,LZ_Tnp_IS481,rve,rve_3
k59_510378_2	1088721.NSU_4422	5.64e-05	46.2	COG2963@1|root,COG2963@2|Bacteria,1NJ26@1224|Proteobacteria,2UKCK@28211|Alphaproteobacteria,2K5Z4@204457|Sphingomonadales	204457|Sphingomonadales	L	Transposase	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_1066436_1	1549858.MC45_01020	1.58e-35	130.0	2C312@1|root,2Z7N1@2|Bacteria,1R9N9@1224|Proteobacteria,2URD6@28211|Alphaproteobacteria,2KA48@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1066438_1	525903.Taci_1204	6.81e-17	75.9	COG0851@1|root,COG0851@2|Bacteria,3TBIQ@508458|Synergistetes	508458|Synergistetes	D	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell	minE	-	-	ko:K03608	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	MinE
k59_1066438_2	642492.Clole_2099	2.19e-17	80.1	COG2894@1|root,COG2894@2|Bacteria,1TP6P@1239|Firmicutes,249BB@186801|Clostridia	186801|Clostridia	D	Belongs to the ParA family	minD	-	-	ko:K03609	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31,CbiA
k59_1288736_1	266835.14025786	2.39e-23	101.0	COG4584@1|root,COG4584@2|Bacteria,1MW5J@1224|Proteobacteria,2TRKA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG4584 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_1733427_1	748247.AZKH_0086	5.24e-93	282.0	COG0846@1|root,COG0846@2|Bacteria,1PYW1@1224|Proteobacteria,2WE0M@28216|Betaproteobacteria,2KYCP@206389|Rhodocyclales	206389|Rhodocyclales	K	SIR2-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SIR2_2
k59_1177674_1	1035308.AQYY01000002_gene632	2.79e-76	256.0	COG2132@1|root,COG2132@2|Bacteria,1TQSU@1239|Firmicutes,24CJP@186801|Clostridia,260KE@186807|Peptococcaceae	186801|Clostridia	Q	Multicopper oxidase	-	-	1.16.3.3	ko:K06324	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
k59_1122581_1	1131814.JAFO01000001_gene4235	1.97e-102	308.0	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2TTYC@28211|Alphaproteobacteria,3EZQG@335928|Xanthobacteraceae	28211|Alphaproteobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_621422_1	204773.HEAR3216	1.08e-114	340.0	COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,2VI0E@28216|Betaproteobacteria,475AE@75682|Oxalobacteraceae	28216|Betaproteobacteria	L	Homeodomain-like domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_38,rve
k59_747084_2	1095747.HMPREF1049_0232	0.000515	42.0	COG5496@1|root,COG5496@2|Bacteria,37A4J@32066|Fusobacteria	32066|Fusobacteria	S	Thioesterase	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
k59_969894_1	941639.BCO26_0001	5.61e-64	213.0	COG0593@1|root,COG0593@2|Bacteria,1TPV7@1239|Firmicutes,4H9MW@91061|Bacilli,1ZBKI@1386|Bacillus	91061|Bacilli	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0042802,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
k59_1080353_2	351348.Maqu_0995	1.03e-61	202.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,1RMAQ@1236|Gammaproteobacteria,465EU@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	COG3547 Transposase and inactivated derivatives	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_579469_1	1205908.AKXW01000109_gene1474	4.43e-96	298.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,1TFGC@1236|Gammaproteobacteria,1Y0A3@135623|Vibrionales	135623|Vibrionales	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_1415353_1	582744.Msip34_0470	2.2e-17	82.0	COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,2VIBZ@28216|Betaproteobacteria,2KMG6@206350|Nitrosomonadales	206350|Nitrosomonadales	GM	Saccharopine dehydrogenase NADP binding domain	-	-	1.6.5.3,1.6.99.3	ko:K00329,ko:K00356	ko00190,map00190	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	Epimerase
k59_1415353_2	323097.Nham_2428	7.36e-31	115.0	COG0625@1|root,COG0625@2|Bacteria,1PHM1@1224|Proteobacteria,2TTQZ@28211|Alphaproteobacteria,3JVI7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Glutathione S-transferase	gstch10	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C_2,GST_N_3
k59_1471547_1	1244869.H261_16296	4.89e-11	62.4	COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,2TS3N@28211|Alphaproteobacteria,2JPEI@204441|Rhodospirillales	204441|Rhodospirillales	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
k59_1471547_2	570952.ATVH01000013_gene2706	1.46e-10	58.2	COG5508@1|root,COG5508@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1674)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1674
k59_804075_1	398767.Glov_0077	2.9e-129	373.0	COG1878@1|root,COG1878@2|Bacteria,1MWWB@1224|Proteobacteria,42UUC@68525|delta/epsilon subdivisions,2WQ03@28221|Deltaproteobacteria,43VS7@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
k59_1748314_1	1267533.KB906740_gene214	4.24e-29	116.0	COG0058@1|root,COG0058@2|Bacteria,3Y65H@57723|Acidobacteria,2JM98@204432|Acidobacteriia	204432|Acidobacteriia	G	Carbohydrate phosphorylase	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
k59_81140_1	1183377.Py04_0863	1.46e-26	107.0	COG2403@1|root,arCOG01229@2157|Archaea,2XVYH@28890|Euryarchaeota,24343@183968|Thermococci	183968|Thermococci	S	CobW/HypB/UreG, nucleotide-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cobW
k59_81140_2	10228.TriadP21266	6.93e-19	86.3	COG1011@1|root,2S0RM@2759|Eukaryota,38EW7@33154|Opisthokonta	33154|Opisthokonta	S	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
k59_636252_1	195250.CM001776_gene3661	1.87e-07	48.9	COG1598@1|root,COG1598@2|Bacteria,1G94Z@1117|Cyanobacteria	1117|Cyanobacteria	S	HicB_like antitoxin of bacterial toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	HicB_lk_antitox
k59_636252_2	118161.KB235922_gene600	9.72e-31	109.0	COG1724@1|root,COG1724@2|Bacteria,1GFI8@1117|Cyanobacteria	1117|Cyanobacteria	N	HicA toxin of bacterial toxin-antitoxin,	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
k59_636252_3	272134.KB731326_gene335	4.35e-19	86.3	COG3666@1|root,COG3666@2|Bacteria,1GEUC@1117|Cyanobacteria	1117|Cyanobacteria	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_693378_1	349102.Rsph17025_1783	1.03e-73	241.0	COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,2TR5K@28211|Alphaproteobacteria,1FB32@1060|Rhodobacter	28211|Alphaproteobacteria	F	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
k59_1138256_1	886293.Sinac_7202	3.8e-07	57.8	COG2010@1|root,COG2010@2|Bacteria,2J547@203682|Planctomycetes	203682|Planctomycetes	C	PFAM Copper type II ascorbate-dependent monooxygenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Cu2_monoox_C
k59_971417_1	1121346.KB899812_gene2005	4.85e-29	115.0	COG4330@1|root,COG4330@2|Bacteria,1VEKF@1239|Firmicutes,4HPYW@91061|Bacilli,26RZG@186822|Paenibacillaceae	91061|Bacilli	S	Protein of unknown function (DUF1361)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1361
k59_1193228_1	1123368.AUIS01000006_gene566	6.7e-103	321.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,2NDJD@225057|Acidithiobacillales	225057|Acidithiobacillales	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF,PAS_4,Response_reg
k59_916713_1	388739.RSK20926_22789	1.4e-61	206.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2TQMR@28211|Alphaproteobacteria,2P1B8@2433|Roseobacter	28211|Alphaproteobacteria	P	COG1132 ABC-type multidrug transport system, ATPase and permease components	msbA2	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_1138259_1	1128421.JAGA01000001_gene2412	1.04e-50	177.0	COG1052@1|root,COG1052@2|Bacteria,2NS44@2323|unclassified Bacteria	2|Bacteria	E	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	serA	-	1.1.1.310,1.1.1.399,1.1.1.95	ko:K00058,ko:K16843	ko00260,ko00270,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513,R05693	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
k59_471677_1	1283283.ATXA01000001_gene817	1.58e-16	85.5	COG0815@1|root,COG0815@2|Bacteria,2GJ9F@201174|Actinobacteria,4ERH9@85013|Frankiales	201174|Actinobacteria	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
k59_1582377_1	1463887.KL589985_gene2856	1.08e-24	102.0	COG4315@1|root,COG4315@2|Bacteria,2GNDV@201174|Actinobacteria	201174|Actinobacteria	S	Secreted repeat of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	Lipoprotein_15
k59_1193241_1	1122612.AUBA01000004_gene446	3.99e-32	124.0	COG0657@1|root,COG0657@2|Bacteria,1R4AU@1224|Proteobacteria,2UGA3@28211|Alphaproteobacteria,2KA2J@204457|Sphingomonadales	204457|Sphingomonadales	I	Carboxylesterase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
k59_693405_1	498211.CJA_2554	2.62e-109	329.0	COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,1RPBY@1236|Gammaproteobacteria,1FFVU@10|Cellvibrio	1236|Gammaproteobacteria	L	MgsA AAA+ ATPase C terminal	rarA	GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0030894,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901576	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
k59_916739_1	1123320.KB889675_gene4064	4.56e-37	133.0	COG3467@1|root,COG3467@2|Bacteria,2GJ76@201174|Actinobacteria	201174|Actinobacteria	J	Flavin-nucleotide-binding protein	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Pyridox_ox_2
k59_1582390_2	671143.DAMO_0005	3.77e-54	183.0	COG0612@1|root,COG0612@2|Bacteria,2NP50@2323|unclassified Bacteria	2|Bacteria	S	Insulinase (Peptidase family M16)	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_81182_1	391735.Veis_0733	2.13e-37	143.0	COG3396@1|root,COG3396@2|Bacteria,1MXUK@1224|Proteobacteria,2VH89@28216|Betaproteobacteria,4ACAF@80864|Comamonadaceae	28216|Betaproteobacteria	S	benzoyl-CoA oxygenase	boxB	-	1.14.13.208	ko:K15512	ko00362,map00362	-	R09555	RC01739	ko00000,ko00001,ko01000	-	-	-	-
k59_414883_1	278963.ATWD01000001_gene3283	2.62e-17	82.8	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_580865_1	1121406.JAEX01000003_gene1513	5.57e-20	94.0	COG2206@1|root,COG3437@1|root,COG2206@2|Bacteria,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,42T7G@68525|delta/epsilon subdivisions,2WKC5@28221|Deltaproteobacteria,2M8BD@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	metal-dependent phosphohydrolase HD	-	-	-	-	-	-	-	-	-	-	-	-	HD,HD_5,Response_reg
k59_1636785_1	760192.Halhy_5840	6.96e-05	52.4	COG4733@1|root,COG4733@2|Bacteria,4NPYJ@976|Bacteroidetes,1IV35@117747|Sphingobacteriia	976|Bacteroidetes	S	Concanavalin A-like lectin/glucanases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3
k59_247725_1	1125973.JNLC01000018_gene2121	6.75e-38	136.0	COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,2TSKN@28211|Alphaproteobacteria,3JUS0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
k59_1027657_1	1120958.AULD01000010_gene2461	6.26e-50	171.0	COG0533@1|root,COG0533@2|Bacteria,2GJ98@201174|Actinobacteria,4FKR0@85023|Microbacteriaceae	201174|Actinobacteria	O	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Acetyltransf_1,Peptidase_M22
k59_1694216_1	765913.ThidrDRAFT_4488	5.72e-30	121.0	COG3293@1|root,COG3293@2|Bacteria,1N2NW@1224|Proteobacteria	1224|Proteobacteria	L	COG3293 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DUF4096
k59_1304696_1	1379270.AUXF01000005_gene526	7.13e-112	331.0	COG0462@1|root,COG0462@2|Bacteria,1ZT7Q@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
k59_636325_1	414684.RC1_3193	7.89e-78	259.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,2TRHQ@28211|Alphaproteobacteria,2JPK2@204441|Rhodospirillales	204441|Rhodospirillales	E	glutamate synthase	gltB	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_1526664_1	1379270.AUXF01000004_gene3238	8.53e-68	219.0	COG0162@1|root,COG0162@2|Bacteria,1ZT43@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
k59_858379_1	32057.KB217478_gene7447	3.51e-111	328.0	COG0667@1|root,COG0667@2|Bacteria,1G2QT@1117|Cyanobacteria,1HRA6@1161|Nostocales	1117|Cyanobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_1304710_1	1306406.ASHX01000002_gene5066	6.16e-39	140.0	COG0702@1|root,COG0702@2|Bacteria,2GM39@201174|Actinobacteria	201174|Actinobacteria	GM	NmrA family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase,NAD_binding_10,RmlD_sub_bind
k59_1250569_1	639283.Snov_0580	1.21e-64	204.0	COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,2TRYS@28211|Alphaproteobacteria,3EY7Y@335928|Xanthobacteraceae	28211|Alphaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	paaF	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
k59_1636805_1	671143.DAMO_2917	1.61e-82	272.0	COG0667@1|root,COG1331@1|root,COG0667@2|Bacteria,COG1331@2|Bacteria,2NP26@2323|unclassified Bacteria	2|Bacteria	O	Protein of unknown function, DUF255	yyaL	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,GlcNAc_2-epim,Thioredox_DsbH
k59_358834_1	671143.DAMO_2896	5.57e-61	212.0	COG0210@1|root,COG2887@1|root,COG0210@2|Bacteria,COG2887@2|Bacteria,2NNZG@2323|unclassified Bacteria	2|Bacteria	L	UvrD/REP helicase N-terminal domain	-	-	3.6.4.12	ko:K03657,ko:K07465	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
k59_81252_1	159087.Daro_4051	1.79e-05	46.6	COG1729@1|root,COG1729@2|Bacteria,1MUSV@1224|Proteobacteria,2VIPC@28216|Betaproteobacteria,2KW31@206389|Rhodocyclales	206389|Rhodocyclales	D	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division	cpoB	-	-	-	-	-	-	-	-	-	-	-	TPR_6,TolA_bind_tri
k59_81252_2	1163617.SCD_n00678	3.94e-10	63.2	COG1729@1|root,COG1729@2|Bacteria,1MUSV@1224|Proteobacteria,2VIPC@28216|Betaproteobacteria	28216|Betaproteobacteria	D	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division	cpoB	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6,TolA_bind_tri,YfiO
k59_1360229_1	575540.Isop_3231	4.4e-24	95.1	COG2146@1|root,COG2146@2|Bacteria,2J13Z@203682|Planctomycetes	203682|Planctomycetes	C	of nitrite reductase and ring-hydroxylating	-	-	-	ko:K05710	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002	-	-	-	Rieske
k59_1360229_2	935548.KI912159_gene1664	5.89e-07	52.4	COG1028@1|root,COG1028@2|Bacteria,1MXE0@1224|Proteobacteria,2U1P2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	Dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_1415486_1	1123368.AUIS01000007_gene2819	3.58e-48	164.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,1RN8W@1236|Gammaproteobacteria,2NCEM@225057|Acidithiobacillales	1236|Gammaproteobacteria	BQ	Histone deacetylase domain	-	-	-	ko:K04768	-	-	-	-	ko00000	-	-	-	Hist_deacetyl
k59_1526701_2	1177181.T9A_02004	2.33e-25	100.0	COG1418@1|root,COG1418@2|Bacteria,1RJ5U@1224|Proteobacteria,1SAZE@1236|Gammaproteobacteria,1XPKV@135619|Oceanospirillales	135619|Oceanospirillales	S	mRNA catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1360239_2	317025.Tcr_2171	1.1e-05	47.0	COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,1RPHK@1236|Gammaproteobacteria,460DM@72273|Thiotrichales	72273|Thiotrichales	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
k59_1582476_1	309801.trd_0142	1.88e-78	245.0	COG0095@1|root,COG0095@2|Bacteria	2|Bacteria	H	Lipoate-protein ligase	-	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB,Lip_prot_lig_C
k59_971535_1	671143.DAMO_2237	9.61e-56	181.0	COG0107@1|root,COG0107@2|Bacteria,2NNMK@2323|unclassified Bacteria	2|Bacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	GO:0000105,GO:0000107,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009382,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234	3.5.4.19,3.6.1.31	ko:K01663,ko:K02500,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037,R04558	RC00002,RC00010,RC01055,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	iECO111_1330.ECO111_2749,iEcolC_1368.EcolC_1617,iHN637.CLJU_RS05755,iLJ478.TM1036,iSB619.SA_RS14115,iYL1228.KPN_02481	His_biosynth
k59_971535_2	545264.KB898746_gene993	1.03e-06	51.2	COG0106@1|root,COG0106@2|Bacteria,1MW6S@1224|Proteobacteria,1RN3M@1236|Gammaproteobacteria,1WXHX@135613|Chromatiales	135613|Chromatiales	E	TIGRFAM phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase	hisA	-	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
k59_471806_1	1123237.Salmuc_03266	8.66e-25	98.2	COG1149@1|root,COG1149@2|Bacteria,1QZ2E@1224|Proteobacteria,2TYAR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	4Fe-4S dicluster domain	napF	-	-	ko:K02572	-	-	-	-	ko00000	-	-	-	Fer4_7
k59_471806_2	1305735.JAFT01000005_gene2303	9.74e-30	107.0	COG3062@1|root,COG3062@2|Bacteria,1N7J1@1224|Proteobacteria,2UIFA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	NapD protein	napD	-	-	ko:K02570	-	-	-	-	ko00000	-	-	-	NapD
k59_1582487_1	1120946.AUBF01000004_gene1663	7.34e-51	173.0	COG0540@1|root,COG0540@2|Bacteria,2GKNA@201174|Actinobacteria,4D3CJ@85005|Actinomycetales	201174|Actinobacteria	F	Belongs to the ATCase OTCase family	pyrB	GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_580947_1	1229780.BN381_250087	4.14e-45	162.0	COG0657@1|root,COG0657@2|Bacteria,2HXWT@201174|Actinobacteria,3UX8E@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	I	Carboxylesterase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
k59_192159_1	981383.AEWH01000004_gene3358	1.07e-11	62.4	COG0858@1|root,COG0858@2|Bacteria,1VA0P@1239|Firmicutes,4HII1@91061|Bacilli	91061|Bacilli	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
k59_192159_2	935948.KE386494_gene246	1.07e-39	148.0	COG0532@1|root,COG0532@2|Bacteria,1TPAI@1239|Firmicutes,248SJ@186801|Clostridia,42EP2@68295|Thermoanaerobacterales	186801|Clostridia	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
k59_247801_1	219305.MCAG_03350	1.39e-42	154.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,4D9SG@85008|Micromonosporales	201174|Actinobacteria	P	Heavy metal translocating P-type atpase	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
k59_247801_2	1158150.KB906243_gene1682	1.2e-06	50.4	COG2010@1|root,COG2010@2|Bacteria,1MZSK@1224|Proteobacteria,1SDUY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
k59_1748472_1	680198.SCAB_5971	2.84e-46	155.0	COG0491@1|root,COG0491@2|Bacteria,2GJ6X@201174|Actinobacteria	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_192169_1	555779.Dthio_PD3238	6.36e-53	185.0	COG0369@1|root,COG1151@2|Bacteria,1NYH2@1224|Proteobacteria,42NE1@68525|delta/epsilon subdivisions,2WIVX@28221|Deltaproteobacteria,2M9QY@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	TIGRFAM Carbon-monoxide dehydrogenase, catalytic subunit	-	-	1.2.7.4	ko:K00198	ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200	M00377	R07157,R08034	RC00250,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Prismane
k59_136460_1	518766.Rmar_0542	5.99e-31	127.0	COG3127@1|root,COG3127@2|Bacteria,4NF16@976|Bacteroidetes,1FIZR@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	Q	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_415005_1	861299.J421_2396	1.09e-66	225.0	COG0188@1|root,COG0188@2|Bacteria,1ZTFF@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_1748478_1	196367.JNFG01000047_gene1371	2.15e-24	97.1	COG0454@1|root,COG0456@2|Bacteria,1N9ZK@1224|Proteobacteria	1224|Proteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
k59_1582526_1	1122135.KB893166_gene2920	3.04e-87	273.0	COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	TRAP-type mannitol chloroaromatic compound transport system large permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_1526755_1	207559.Dde_0700	1.04e-44	161.0	COG0845@1|root,COG0845@2|Bacteria,1MUG6@1224|Proteobacteria,42NC1@68525|delta/epsilon subdivisions,2X5FJ@28221|Deltaproteobacteria,2MGQ8@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	PFAM secretion protein HlyD	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3
k59_1360295_1	420324.KI912061_gene6197	1.24e-113	360.0	COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,1JR57@119045|Methylobacteriaceae	28211|Alphaproteobacteria	T	Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Abhydrolase_1,Guanylate_cyc,TPR_4
k59_136483_1	215803.DB30_0881	7.64e-21	96.7	COG1404@1|root,COG4412@1|root,COG1404@2|Bacteria,COG4412@2|Bacteria,1REF1@1224|Proteobacteria,42Q4N@68525|delta/epsilon subdivisions,2WS51@28221|Deltaproteobacteria,2YWNR@29|Myxococcales	28221|Deltaproteobacteria	O	Fibronectin type 3 domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M6,Peptidase_S8
k59_1415561_1	1218084.BBJK01000135_gene7223	6.43e-85	267.0	COG0492@1|root,COG0492@2|Bacteria,1MVX2@1224|Proteobacteria,2VM3V@28216|Betaproteobacteria,1K4AE@119060|Burkholderiaceae	28216|Betaproteobacteria	C	FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,cNMP_binding
k59_81356_1	1382359.JIAL01000001_gene2763	7.01e-43	155.0	COG5000@1|root,COG5000@2|Bacteria,3Y2TD@57723|Acidobacteria,2JHXU@204432|Acidobacteriia	204432|Acidobacteriia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
k59_1304829_1	1121428.DESHY_70037___1	1.32e-124	373.0	COG0154@1|root,COG0154@2|Bacteria,1TP0C@1239|Firmicutes,24911@186801|Clostridia,2613E@186807|Peptococcaceae	186801|Clostridia	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
k59_1250676_1	179408.Osc7112_0353	1.31e-80	246.0	COG1174@1|root,COG1174@2|Bacteria,1G2ZA@1117|Cyanobacteria,1HAQ8@1150|Oscillatoriales	1117|Cyanobacteria	E	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K05846	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1
k59_916934_1	1401078.HMPREF2140_08070	2.6e-31	123.0	COG0793@1|root,COG0793@2|Bacteria,4NFEN@976|Bacteroidetes,2FMMP@200643|Bacteroidia	976|Bacteroidetes	M	peptidase S41	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S41,Tricorn_C1
k59_42776_2	926550.CLDAP_18550	1.06e-18	85.1	COG1001@1|root,COG1001@2|Bacteria,2G64P@200795|Chloroflexi	200795|Chloroflexi	F	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family	ade	-	3.5.4.2	ko:K01486	ko00230,ko01100,map00230,map01100	-	R01244	RC00477	ko00000,ko00001,ko01000	-	-	-	Adenine_deam_C,Amidohydro_1
k59_936398_1	316056.RPC_2115	2.52e-19	89.4	COG2128@1|root,COG2128@2|Bacteria,1MUDM@1224|Proteobacteria,2TTY5@28211|Alphaproteobacteria,3JSMD@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	MA20_26500	-	-	-	-	-	-	-	-	-	-	-	CMD
k59_264624_1	1120933.ATUY01000011_gene640	2.6e-38	137.0	COG0092@1|root,COG0092@2|Bacteria,2GKF1@201174|Actinobacteria,4D3HT@85005|Actinomycetales	201174|Actinobacteria	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
k59_264624_2	96561.Dole_0713	1.42e-08	53.1	COG0091@1|root,COG0091@2|Bacteria,1RH0W@1224|Proteobacteria,42TRE@68525|delta/epsilon subdivisions,2WQBH@28221|Deltaproteobacteria,2MKFE@213118|Desulfobacterales	28221|Deltaproteobacteria	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
k59_42789_2	272630.MexAM1_META1p0990	3.91e-79	251.0	COG0028@1|root,COG0028@2|Bacteria,1MXDW@1224|Proteobacteria,2TT9X@28211|Alphaproteobacteria,1JSHK@119045|Methylobacteriaceae	28211|Alphaproteobacteria	EH	Belongs to the TPP enzyme family	oxc	-	4.1.1.8	ko:K01577	ko00630,ko01100,map00630,map01100	-	R01908	RC00620	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_712425_1	1121946.AUAX01000052_gene8144	2.11e-05	52.4	COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,2GJRI@201174|Actinobacteria,4DBEY@85008|Micromonosporales	201174|Actinobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DZR,Guanylate_cyc
k59_1211070_1	633149.Bresu_0142	6.59e-33	120.0	COG0799@1|root,COG0799@2|Bacteria,1MZEF@1224|Proteobacteria,2UBSV@28211|Alphaproteobacteria,2KGTH@204458|Caulobacterales	204458|Caulobacterales	J	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
k59_1211070_2	1207063.P24_17518	9.61e-29	108.0	COG1576@1|root,COG1576@2|Bacteria,1R9Z2@1224|Proteobacteria,2U95Q@28211|Alphaproteobacteria,2JSBE@204441|Rhodospirillales	204441|Rhodospirillales	J	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA	rlmH	-	2.1.1.177	ko:K00783	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SPOUT_MTase
k59_1046761_1	1502724.FF80_02474	7.65e-48	172.0	COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,2TVQS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	ABC-type Fe3 transport system permease component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
k59_1433594_1	926569.ANT_22430	3.05e-29	107.0	COG0238@1|root,COG0238@2|Bacteria,2G756@200795|Chloroflexi	200795|Chloroflexi	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	-	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
k59_1433594_2	926569.ANT_22420	3.32e-32	115.0	COG0629@1|root,COG0629@2|Bacteria,2G6YE@200795|Chloroflexi	200795|Chloroflexi	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
k59_264640_1	649831.L083_8107	8.1e-51	170.0	COG3279@1|root,COG3279@2|Bacteria,2GKK5@201174|Actinobacteria,4D985@85008|Micromonosporales	201174|Actinobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	LytTR,Response_reg
k59_42805_1	1123052.AUDF01000003_gene297	2.97e-30	121.0	COG0021@1|root,COG0021@2|Bacteria,2GJ1K@201174|Actinobacteria,4FM21@85023|Microbacteriaceae	201174|Actinobacteria	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
k59_42805_2	1232452.BAIB02000020_gene2678	0.00048	41.6	COG0698@1|root,COG0698@2|Bacteria,1TTQV@1239|Firmicutes,25214@186801|Clostridia,26BZ1@186813|unclassified Clostridiales	2|Bacteria	G	Ribose/Galactose Isomerase	rpiB	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2621	LacAB_rpiB
k59_653189_1	1027273.GZ77_04515	5.42e-24	103.0	COG4536@1|root,COG4536@2|Bacteria,1NZ99@1224|Proteobacteria,1RNCE@1236|Gammaproteobacteria,1XH4G@135619|Oceanospirillales	135619|Oceanospirillales	P	Mg2 and Co2 transporter CorB	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
k59_1269575_1	471857.Svir_34370	3.78e-12	65.9	COG1801@1|root,COG1801@2|Bacteria,2GMSP@201174|Actinobacteria,4E0MV@85010|Pseudonocardiales	201174|Actinobacteria	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
k59_1100688_1	1123242.JH636435_gene2847	1.23e-22	103.0	COG0842@1|root,COG1129@1|root,COG0842@2|Bacteria,COG1129@2|Bacteria,2IWZA@203682|Planctomycetes	203682|Planctomycetes	V	ABC-type multidrug transport system ATPase component	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_3,ABC_tran
k59_1765566_1	1122919.KB905589_gene4112	1.23e-61	204.0	COG2133@1|root,COG2133@2|Bacteria,1TR38@1239|Firmicutes,4HBME@91061|Bacilli,26SSJ@186822|Paenibacillaceae	91061|Bacilli	G	Quinoprotein glucose dehydrogenase	gdhB	-	-	-	-	-	-	-	-	-	-	-	GSDH
k59_377478_1	443598.AUFA01000025_gene1837	6.7e-61	194.0	COG1057@1|root,COG1057@2|Bacteria,1RD0J@1224|Proteobacteria,2U6ZC@28211|Alphaproteobacteria,3JTPE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
k59_1543396_1	243924.LT42_20950	3.51e-73	234.0	COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,1RNVQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	found to be peripherally associated with the inner membrane in Escherichia coli	trkA	GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0015075,GO:0015672,GO:0016020,GO:0022857,GO:0030001,GO:0034220,GO:0051179,GO:0051234,GO:0055085,GO:0098655	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	iE2348C_1286.E2348C_3552	TrkA_C,TrkA_N
k59_1211100_1	1123278.KB893559_gene3006	1.15e-13	73.9	COG4464@1|root,COG4464@2|Bacteria,4NMUT@976|Bacteroidetes,47PBY@768503|Cytophagia	976|Bacteroidetes	GM	capsular polysaccharide biosynthesis protein	-	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	-
k59_99391_1	1382356.JQMP01000003_gene1989	7.11e-22	95.5	COG0166@1|root,COG0176@1|root,COG0166@2|Bacteria,COG0176@2|Bacteria,2G67J@200795|Chloroflexi,27XXA@189775|Thermomicrobia	189775|Thermomicrobia	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2,5.3.1.9	ko:K13810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00004,M00007,M00114	R01827,R02739,R02740,R03321	RC00376,RC00439,RC00563,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	PGI,TAL_FSA
k59_99391_2	97139.C824_04225	2.09e-26	103.0	COG0698@1|root,COG0698@2|Bacteria,1V3HE@1239|Firmicutes,24JWT@186801|Clostridia,36I0M@31979|Clostridiaceae	186801|Clostridia	G	Ribose 5-phosphate isomerase	rpiB	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
k59_1156738_1	203123.OEOE_0638	2.76e-15	75.1	COG0126@1|root,COG0126@2|Bacteria,1TP3H@1239|Firmicutes,4H9R3@91061|Bacilli,4AX5R@81850|Leuconostocaceae	91061|Bacilli	F	Belongs to the phosphoglycerate kinase family	pgk	GO:0001871,GO:0002020,GO:0003674,GO:0003824,GO:0004618,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009893,GO:0009986,GO:0009987,GO:0010468,GO:0010604,GO:0010628,GO:0010755,GO:0010756,GO:0010954,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019222,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0019899,GO:0030162,GO:0030193,GO:0030195,GO:0030246,GO:0030247,GO:0030312,GO:0031323,GO:0031325,GO:0032101,GO:0032102,GO:0032268,GO:0032270,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043532,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0045862,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0048518,GO:0048519,GO:0048522,GO:0048583,GO:0048585,GO:0050789,GO:0050794,GO:0050818,GO:0050819,GO:0050878,GO:0051171,GO:0051173,GO:0051186,GO:0051188,GO:0051239,GO:0051241,GO:0051246,GO:0051247,GO:0051917,GO:0051919,GO:0055086,GO:0060255,GO:0061041,GO:0061045,GO:0065007,GO:0065008,GO:0070613,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0080134,GO:0090407,GO:1900046,GO:1900047,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1903034,GO:1903035,GO:1903317,GO:1903319,GO:2001065	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iSB619.SA_RS04145	PGK
k59_1156738_2	1087481.AGFX01000038_gene1433	4.2e-58	192.0	COG0148@1|root,COG0148@2|Bacteria,1TP2S@1239|Firmicutes,4HAKI@91061|Bacilli,26REN@186822|Paenibacillaceae	91061|Bacilli	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	GO:0001968,GO:0003674,GO:0003824,GO:0004634,GO:0005488,GO:0005515,GO:0005518,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0019899,GO:0030312,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035375,GO:0042866,GO:0043236,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0044877,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0050840,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
k59_765757_1	42256.RradSPS_2408	2.38e-35	135.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,2GK2C@201174|Actinobacteria,4CQ32@84995|Rubrobacteria	84995|Rubrobacteria	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.5.1	ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
k59_1654153_1	1121028.ARQE01000016_gene2619	6.44e-133	381.0	COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,2PK0U@255475|Aurantimonadaceae	28211|Alphaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve,rve_3
k59_1654153_2	648885.KB316282_gene2129	1.6e-41	138.0	COG2963@1|root,COG2963@2|Bacteria,1RGZ5@1224|Proteobacteria,2UAIS@28211|Alphaproteobacteria,1JVU8@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
k59_264678_1	102232.GLO73106DRAFT_00031720	1.16e-13	73.2	28NSZ@1|root,2ZBRT@2|Bacteria,1G51D@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1543418_1	591157.SSLG_00116	5.02e-73	232.0	COG3328@1|root,COG3328@2|Bacteria,2GM8F@201174|Actinobacteria	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_99403_1	1089550.ATTH01000001_gene332	1.27e-17	85.9	COG0654@1|root,COG0654@2|Bacteria,4PM2V@976|Bacteroidetes,1FJWJ@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	CH	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3,Pyr_redox_2
k59_1269619_1	767817.Desgi_3200	7.39e-26	110.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1TPTQ@1239|Firmicutes,249CX@186801|Clostridia,264SK@186807|Peptococcaceae	186801|Clostridia	C	Acyl-CoA synthetase (NDP forming)	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
k59_264686_1	314285.KT71_03022	1.95e-74	236.0	COG0624@1|root,COG0624@2|Bacteria,1MVUX@1224|Proteobacteria,1RPPD@1236|Gammaproteobacteria,1J8J6@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Peptidase family M28	-	-	3.5.1.6,3.5.1.87	ko:K06016	ko00240,ko01100,map00240,map01100	M00046	R00905,R04666	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
k59_1269620_1	246197.MXAN_3431	2.57e-30	122.0	COG1538@1|root,COG1538@2|Bacteria,1MWB0@1224|Proteobacteria,42UCF@68525|delta/epsilon subdivisions,2WREI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	MU	Outer membrane efflux protein	-	-	-	ko:K15725	-	-	-	-	ko00000,ko02000	1.B.17.2.2	-	-	OEP
k59_1765614_1	1173023.KE650771_gene578	4.39e-39	145.0	COG4292@1|root,COG4292@2|Bacteria,1G40Y@1117|Cyanobacteria,1JHJK@1189|Stigonemataceae	1117|Cyanobacteria	S	Bacterial low temperature requirement A protein (LtrA)	-	-	-	-	-	-	-	-	-	-	-	-	LtrA
k59_1654174_2	1298867.AUES01000044_gene3386	5.05e-48	166.0	COG4638@1|root,COG4638@2|Bacteria,1MX47@1224|Proteobacteria,2TV03@28211|Alphaproteobacteria,3JTQC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Rieske [2Fe-2S] domain	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
k59_264691_1	1121377.KB906404_gene2871	2.17e-47	167.0	COG1680@1|root,COG1680@2|Bacteria,1WJK2@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_490736_1	761193.Runsl_2487	2.43e-17	84.7	COG4447@1|root,COG4447@2|Bacteria,4NESU@976|Bacteroidetes,47NMF@768503|Cytophagia	976|Bacteroidetes	G	Sortilin, neurotensin receptor 3,	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
k59_432737_1	869213.JCM21142_41833	5.42e-62	212.0	COG1472@1|root,COG1472@2|Bacteria,4NE90@976|Bacteroidetes	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 3 family	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C,PA14
k59_264699_1	667014.Thein_1112	1.22e-25	105.0	COG1269@1|root,COG1269@2|Bacteria,2GICC@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	Transmembrane exosortase (Exosortase_EpsH)	-	-	-	-	-	-	-	-	-	-	-	-	Exosortase_EpsH
k59_712527_1	502025.Hoch_2705	8.29e-75	241.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,42M18@68525|delta/epsilon subdivisions,2WJUK@28221|Deltaproteobacteria,2YU13@29|Myxococcales	28221|Deltaproteobacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	coxA	-	1.10.3.10,1.9.3.1	ko:K02274,ko:K02298	ko00190,ko01100,map00190,map01100	M00155,M00417	R00081,R11335	RC00016,RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.5,3.D.4.6	-	-	COX1
k59_99430_1	1278309.KB907101_gene667	4.04e-36	135.0	COG1073@1|root,COG1073@2|Bacteria,1RGSI@1224|Proteobacteria	1224|Proteobacteria	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_99430_2	1040983.AXAE01000028_gene3976	5.71e-11	60.8	2DMMP@1|root,32SHG@2|Bacteria,1RM15@1224|Proteobacteria,2UAH7@28211|Alphaproteobacteria,43Q54@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_490767_1	99598.Cal7507_3721	1.94e-64	211.0	COG3497@1|root,COG3497@2|Bacteria,1G41S@1117|Cyanobacteria,1HRKD@1161|Nostocales	1117|Cyanobacteria	S	Phage tail sheath C-terminal domain	-	-	-	ko:K06907	-	-	-	-	ko00000	-	-	-	Phage_sheath_1,Phage_sheath_1C
k59_490767_2	477184.KYC_19439	1.58e-40	137.0	2DB76@1|root,2Z7JZ@2|Bacteria,1R41X@1224|Proteobacteria,2VMX8@28216|Betaproteobacteria	28216|Betaproteobacteria	S	T4-like virus tail tube protein gp19	-	-	-	-	-	-	-	-	-	-	-	-	Phage_T4_gp19
k59_264720_1	113395.AXAI01000016_gene4943	4.76e-49	172.0	COG5276@1|root,COG5276@2|Bacteria,1MU72@1224|Proteobacteria,2TZVG@28211|Alphaproteobacteria,3JS0R@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	repeat protein	MA20_04930	-	-	-	-	-	-	-	-	-	-	-	-
k59_936519_2	666686.B1NLA3E_04935	1.14e-27	110.0	COG0247@1|root,COG0247@2|Bacteria,1TPFC@1239|Firmicutes,4HAKC@91061|Bacilli,1ZCUT@1386|Bacillus	91061|Bacilli	C	Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source	lutA	-	-	ko:K18928	-	-	-	-	ko00000	-	-	-	CCG
k59_42909_1	1150621.SMUL_3266	6.08e-49	157.0	2B9ZZ@1|root,323DM@2|Bacteria,1MZ6J@1224|Proteobacteria,42WB2@68525|delta/epsilon subdivisions,2YRYT@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	COG NOG15344 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_264734_1	675635.Psed_2514	2.9e-37	142.0	COG3848@1|root,COG3848@2|Bacteria,2I3FP@201174|Actinobacteria,4E9TT@85010|Pseudonocardiales	201174|Actinobacteria	T	PEP-utilising enzyme, mobile domain	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers
k59_208560_1	1278073.MYSTI_07864	1.54e-56	198.0	COG0577@1|root,COG0577@2|Bacteria,1NREW@1224|Proteobacteria	1224|Proteobacteria	V	COG0577 ABC-type antimicrobial peptide transport system permease component	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_598792_1	314230.DSM3645_24165	4.61e-68	223.0	COG0591@1|root,COG0591@2|Bacteria,2IWSN@203682|Planctomycetes	203682|Planctomycetes	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
k59_1269690_1	246200.SPO3455	4.83e-35	135.0	COG2114@1|root,COG2343@1|root,COG2114@2|Bacteria,COG2343@2|Bacteria,1MWHK@1224|Proteobacteria,2TR2J@28211|Alphaproteobacteria,4NAW3@97050|Ruegeria	28211|Alphaproteobacteria	T	Adenylate guanylate cyclase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,NTP_transf_9
k59_1156863_1	266835.14025743	1.07e-163	464.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_822136_1	1282876.BAOK01000001_gene1113	4.12e-134	394.0	COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,2TR2C@28211|Alphaproteobacteria,4BR8R@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Cytochrome C and Quinol oxidase polypeptide I	ccoN	GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0022900,GO:0022904,GO:0034220,GO:0044237,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600	1.9.3.1	ko:K00404	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	COX1
k59_99500_1	926550.CLDAP_08430	7.32e-35	132.0	COG0265@1|root,COG0265@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	degP	-	1.3.1.74	ko:K08070,ko:K08372	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Trypsin_2
k59_42949_1	1267535.KB906767_gene4612	9.44e-19	90.5	COG0577@1|root,COG0577@2|Bacteria	1267535.KB906767_gene4612|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1100823_1	1133850.SHJG_7330	7.64e-12	68.6	COG1960@1|root,COG1960@2|Bacteria,2IAYB@201174|Actinobacteria	201174|Actinobacteria	I	acyl-CoA dehydrogenase	-	-	1.14.13.235	ko:K22027	-	-	-	-	ko00000,ko01000	-	-	-	Acyl-CoA_dh_2,Acyl-CoA_dh_N
k59_1100823_2	1038869.AXAN01000050_gene5919	0.000696	44.7	COG0454@1|root,COG1846@1|root,COG0456@2|Bacteria,COG1846@2|Bacteria,1MWIC@1224|Proteobacteria,2VJPV@28216|Betaproteobacteria,1KH28@119060|Burkholderiaceae	28216|Betaproteobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,MarR_2
k59_544051_1	1500306.JQLA01000022_gene5802	1.06e-64	213.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TTJP@28211|Alphaproteobacteria,4B97D@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	gamma-aminobutyric acid catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
k59_1156885_1	536227.CcarbDRAFT_4214	1.23e-105	332.0	COG0525@1|root,COG0525@2|Bacteria,1TPN4@1239|Firmicutes,248VC@186801|Clostridia,36E1A@31979|Clostridiaceae	186801|Clostridia	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
k59_1324395_1	1123366.TH3_07437	1.25e-82	263.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2TR3X@28211|Alphaproteobacteria,2JPQA@204441|Rhodospirillales	204441|Rhodospirillales	S	COG0488 ATPase components of ABC transporters with duplicated ATPase domains	uup	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD
k59_1100827_1	485913.Krac_8704	1.31e-33	125.0	28I4Y@1|root,2Z88D@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1433751_1	1379698.RBG1_1C00001G0830	8.73e-66	222.0	COG0480@1|root,COG0480@2|Bacteria,2NNQD@2323|unclassified Bacteria	2|Bacteria	J	elongation factor G	fusA2	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0030312,GO:0044237,GO:0044464,GO:0071944	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_1211238_1	1122134.KB893650_gene587	4.94e-116	341.0	COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,1RMAW@1236|Gammaproteobacteria,1XHDH@135619|Oceanospirillales	135619|Oceanospirillales	F	carbamoyl-phosphate synthetase glutamine chain	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
k59_432824_1	469371.Tbis_2599	1.14e-108	327.0	COG1032@1|root,COG1032@2|Bacteria,2HW71@201174|Actinobacteria,4E7P4@85010|Pseudonocardiales	201174|Actinobacteria	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
k59_1765741_1	391612.CY0110_13831	7.68e-45	160.0	COG0515@1|root,COG0515@2|Bacteria,1G08U@1117|Cyanobacteria,3KH6Q@43988|Cyanothece	1117|Cyanobacteria	KLT	Serine Threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,TPR_1,TPR_2,TPR_8
k59_1765741_2	190486.XAC4116	8.81e-10	62.0	COG0515@1|root,COG1262@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria,1MWVZ@1224|Proteobacteria,1RQBQ@1236|Gammaproteobacteria,1X4P3@135614|Xanthomonadales	135614|Xanthomonadales	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08282	-	-	-	-	ko00000,ko01000	-	-	-	FGE-sulfatase,Pkinase
k59_1379095_1	411483.FAEPRAA2165_02630	2.16e-38	144.0	COG0513@1|root,COG0513@2|Bacteria,1TPAP@1239|Firmicutes,247IT@186801|Clostridia,3WGP7@541000|Ruminococcaceae	186801|Clostridia	L	Belongs to the DEAD box helicase family	rhlE	-	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
k59_1379095_2	768066.HELO_4278	6.13e-05	45.1	COG0545@1|root,COG0545@2|Bacteria,1RDA1@1224|Proteobacteria,1RPMP@1236|Gammaproteobacteria,1XJNV@135619|Oceanospirillales	135619|Oceanospirillales	M	Peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K03772,ko:K03773	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C,FKBP_N
k59_1543539_1	368407.Memar_1797	0.000525	44.7	COG0517@1|root,arCOG00600@2157|Archaea,2XXMJ@28890|Euryarchaeota,2N9JW@224756|Methanomicrobia	224756|Methanomicrobia	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	ko:K07182	-	-	-	-	ko00000	-	-	-	CBS
k59_1100856_1	694431.DESACE_05140	8.03e-20	91.3	COG0810@1|root,COG0810@2|Bacteria,1R330@1224|Proteobacteria,437DK@68525|delta/epsilon subdivisions,2WSN1@28221|Deltaproteobacteria,2M76S@213113|Desulfurellales	28221|Deltaproteobacteria	M	TonB C terminal	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
k59_822192_1	243231.GSU0719	8.29e-26	109.0	COG0412@1|root,COG0412@2|Bacteria,1QW3K@1224|Proteobacteria,43C4E@68525|delta/epsilon subdivisions,2X7EV@28221|Deltaproteobacteria,43S1I@69541|Desulfuromonadales	28221|Deltaproteobacteria	Q	Dienelactone hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_767749_1	671143.DAMO_2939	1.08e-71	221.0	COG0353@1|root,COG0353@2|Bacteria,2NP5N@2323|unclassified Bacteria	2|Bacteria	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	GO:0000731,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	HHH,RecR,Toprim_4
k59_767749_2	293826.Amet_4780	2.2e-11	60.5	COG0718@1|root,COG0718@2|Bacteria,1VA1S@1239|Firmicutes,24MXH@186801|Clostridia,36JG6@31979|Clostridiaceae	186801|Clostridia	S	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection	-	-	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
k59_337815_2	399795.CtesDRAFT_PD4046	4.12e-28	105.0	COG2146@1|root,COG2146@2|Bacteria,1N72F@1224|Proteobacteria,2VTX8@28216|Betaproteobacteria,4AER9@80864|Comamonadaceae	28216|Betaproteobacteria	P	PFAM Rieske 2Fe-2S domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
k59_949636_1	216596.RL4151	1.07e-73	233.0	COG3039@1|root,COG3039@2|Bacteria,1QQ9Q@1224|Proteobacteria,2UEEB@28211|Alphaproteobacteria,4BAW0@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	High confidence in function and specificity	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_894150_2	675806.VII_000603	3.64e-44	151.0	COG3717@1|root,COG3717@2|Bacteria,1MU9D@1224|Proteobacteria,1RPDB@1236|Gammaproteobacteria,1XSKN@135623|Vibrionales	135623|Vibrionales	G	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate	kduI	-	5.3.1.17	ko:K01815	ko00040,map00040	-	R04383	RC00541	ko00000,ko00001,ko01000	-	-	-	KduI
k59_838256_1	1123037.AUDE01000039_gene2702	3.6e-08	62.4	COG4916@1|root,COG4916@2|Bacteria	2|Bacteria	S	TIR domain	-	-	-	-	-	-	-	-	-	-	-	-	TIR_2
k59_393647_1	316273.XCV1748	4.1e-38	141.0	COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,1RMCI@1236|Gammaproteobacteria,1X3J8@135614|Xanthomonadales	135614|Xanthomonadales	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parE	-	-	ko:K02622	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_1616561_1	426716.JOAJ01000008_gene4926	4.77e-96	301.0	COG0556@1|root,COG0556@2|Bacteria,2GJ03@201174|Actinobacteria,4FX33@85025|Nocardiaceae	201174|Actinobacteria	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	GO:0002682,GO:0002684,GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0008150,GO:0009605,GO:0009607,GO:0016020,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0044464,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0071944,GO:0075136	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
k59_449393_1	671143.DAMO_0001	2.2e-101	306.0	COG0593@1|root,COG0593@2|Bacteria,2NNTK@2323|unclassified Bacteria	2|Bacteria	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006275,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010556,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1901576,GO:1990837,GO:2000112	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
k59_894173_1	929703.KE386491_gene2656	1.74e-12	72.4	COG4365@1|root,COG4365@2|Bacteria,4NGCF@976|Bacteroidetes,47JYH@768503|Cytophagia	976|Bacteroidetes	S	Belongs to the BshC family	bshC	-	-	ko:K22136	-	-	-	-	ko00000	-	-	-	BshC
k59_226907_1	1191523.MROS_0698	4.7e-86	267.0	COG3033@1|root,COG3033@2|Bacteria	2|Bacteria	E	tryptophanase activity	tnaA	-	4.1.99.1	ko:K01667	ko00380,map00380	-	R00673	RC00209,RC00355	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
k59_1394204_1	555088.DealDRAFT_0874	1.12e-24	103.0	COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,247RK@186801|Clostridia,42JIV@68298|Syntrophomonadaceae	186801|Clostridia	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
k59_226911_1	706587.Desti_3270	4.31e-41	154.0	COG2202@1|root,COG2203@1|root,COG2204@1|root,COG4191@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2204@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIU5@28221|Deltaproteobacteria,2MQZQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
k59_1060694_1	452637.Oter_1883	4.63e-16	79.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_504962_1	1121104.AQXH01000001_gene1386	1.01e-35	140.0	COG2091@1|root,COG2091@2|Bacteria,4NGXG@976|Bacteroidetes	976|Bacteroidetes	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
k59_1228032_1	1232683.ADIMK_1268	2.1e-87	270.0	COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,1RMR4@1236|Gammaproteobacteria,464HF@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntB	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
k59_1338781_1	1304880.JAGB01000002_gene1556	1.04e-30	128.0	COG3328@1|root,COG3328@2|Bacteria,1TP4C@1239|Firmicutes,248UI@186801|Clostridia	186801|Clostridia	L	PFAM transposase, mutator	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_449416_1	948106.AWZT01000036_gene1751	2.1e-109	325.0	COG0523@1|root,COG0523@2|Bacteria,1MVZV@1224|Proteobacteria,2VIHH@28216|Betaproteobacteria,1K1R3@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Cobalamin synthesis protein cobW C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	CobW_C,cobW
k59_1450152_1	671143.DAMO_0566	7.48e-87	265.0	COG0202@1|root,COG0202@2|Bacteria,2NNQQ@2323|unclassified Bacteria	2|Bacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	GO:0003674,GO:0003824,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
k59_1450152_2	502025.Hoch_3980	1.4e-93	279.0	COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,42M5X@68525|delta/epsilon subdivisions,2WJGN@28221|Deltaproteobacteria,2YU1D@29|Myxococcales	28221|Deltaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
k59_1450152_3	562970.Btus_0180	5.61e-30	108.0	COG0100@1|root,COG0100@2|Bacteria,1V3IK@1239|Firmicutes,4HH2T@91061|Bacilli,279QJ@186823|Alicyclobacillaceae	91061|Bacilli	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
k59_1228041_1	866895.HBHAL_1928	0.000909	47.0	COG1277@1|root,COG1277@2|Bacteria,1UYUR@1239|Firmicutes,4HEAP@91061|Bacilli,3NFQ9@45667|Halobacillus	91061|Bacilli	S	COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component	yxlG	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_5
k59_60152_1	323098.Nwi_1138	8.95e-10	64.7	COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,3JTUH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	His Kinase A (phosphoacceptor) domain	cckA	-	2.7.13.3	ko:K13587	ko02020,ko04112,map02020,map04112	M00512	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9,Response_reg
k59_727458_1	670292.JH26_10020	9.51e-164	464.0	COG2801@1|root,COG2801@2|Bacteria,1MWNX@1224|Proteobacteria,2TZ7M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	LZ_Tnp_IS481,rve,rve_3
k59_393723_1	1123276.KB893272_gene2436	3.34e-44	157.0	COG3385@1|root,COG3385@2|Bacteria,4P02Y@976|Bacteroidetes,47TUA@768503|Cytophagia	976|Bacteroidetes	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_616011_1	883066.HMPREF9233_00925	1.33e-06	49.7	COG3333@1|root,COG3333@2|Bacteria,2GJB2@201174|Actinobacteria	201174|Actinobacteria	S	Tripartite tricarboxylate transporter TctA	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
k59_671805_1	1183438.GKIL_0576	1.74e-09	64.7	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	dpp4	-	3.4.14.5	ko:K01278	ko04974,map04974	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	DPPIV_N,PD40,Peptidase_S9
k59_1171993_1	931626.Awo_c21360	3.92e-12	66.2	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1TPKJ@1239|Firmicutes,248NG@186801|Clostridia,25UTU@186806|Eubacteriaceae	186801|Clostridia	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_1171993_2	1047013.AQSP01000098_gene2562	3.8e-11	64.3	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_949727_1	247490.KSU1_B0268	4.81e-62	211.0	COG1271@1|root,COG1271@2|Bacteria	2|Bacteria	C	aerobic electron transport chain	-	-	1.10.3.14	ko:K00425,ko:K08738	ko00190,ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00190,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00153,M00595	R10151,R11325	RC00061,RC03151,RC03152	ko00000,ko00001,ko00002,ko01000	3.D.4.3,3.D.4.6	-	-	Cyt_bd_oxida_I,Cytochrome_CBB3
k59_505037_1	697282.Mettu_2842	2.84e-11	63.2	COG0650@1|root,COG0650@2|Bacteria,1MXV5@1224|Proteobacteria,1RPCY@1236|Gammaproteobacteria,1XE7T@135618|Methylococcales	135618|Methylococcales	C	NADH dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NADHdh
k59_505037_2	395493.BegalDRAFT_2143	9.43e-56	193.0	COG0651@1|root,COG0651@2|Bacteria,1QU5Z@1224|Proteobacteria,1T20X@1236|Gammaproteobacteria	1236|Gammaproteobacteria	CP	PFAM NADH Ubiquinone plastoquinone (complex I)	-	-	-	ko:K12137	-	-	-	-	ko00000,ko01000	-	-	-	Proton_antipo_M
k59_949747_1	929558.SMGD1_0248	2.45e-51	183.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2YNQF@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	P	COG0474 Cation transport ATPase	-	-	-	-	-	-	-	-	-	-	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
k59_894268_1	319795.Dgeo_1302	1.13e-26	113.0	COG5659@1|root,COG5659@2|Bacteria	2|Bacteria	L	transposition	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
k59_1172027_2	1298593.TOL_1522	1.65e-71	228.0	COG0006@1|root,COG0006@2|Bacteria,1MWUT@1224|Proteobacteria,1RZSD@1236|Gammaproteobacteria,1XHVN@135619|Oceanospirillales	135619|Oceanospirillales	E	Creatinase/Prolidase N-terminal domain	-	-	3.4.13.9	ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
k59_1505520_1	105425.BBPL01000019_gene198	4.77e-20	94.0	COG0446@1|root,COG0446@2|Bacteria,2GJM6@201174|Actinobacteria,2NEX0@228398|Streptacidiphilus	201174|Actinobacteria	S	BFD-like [2Fe-2S] binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer2_BFD,Pyr_redox_2
k59_4784_1	426355.Mrad2831_3228	4.45e-13	68.2	COG0625@1|root,COG0625@2|Bacteria,1RHSK@1224|Proteobacteria,2U5GF@28211|Alphaproteobacteria,1JRUM@119045|Methylobacteriaceae	28211|Alphaproteobacteria	O	PFAM Glutathione S-transferase domain	yibF	-	-	-	-	-	-	-	-	-	-	-	GST_C_2,GST_N_3
k59_115723_1	755732.Fluta_2169	4.77e-18	87.0	COG0438@1|root,COG0438@2|Bacteria,4NU4C@976|Bacteroidetes,1I610@117743|Flavobacteriia,2PC3C@246874|Cryomorphaceae	976|Bacteroidetes	M	Glycosyl transferase 4-like	remC	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_2,Glycos_transf_1
k59_782925_2	313596.RB2501_14839	7.63e-62	210.0	COG2091@1|root,COG2091@2|Bacteria,4NFQ6@976|Bacteroidetes,1HZHJ@117743|Flavobacteriia	976|Bacteroidetes	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
k59_1060818_1	187272.Mlg_2693	4.72e-49	162.0	COG5622@1|root,COG5622@2|Bacteria,1NPM6@1224|Proteobacteria	1224|Proteobacteria	N	Protein required for attachment to host cells	-	-	-	-	-	-	-	-	-	-	-	-	Host_attach
k59_1616706_1	266779.Meso_2971	2.31e-61	203.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,43GQI@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	CoA-transferase family III	MA20_38225	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
k59_1616706_2	1440053.JOEI01000019_gene709	5.43e-25	99.8	COG2030@1|root,COG2030@2|Bacteria,2IBNG@201174|Actinobacteria	201174|Actinobacteria	I	MaoC like domain	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
k59_1228159_1	1547437.LL06_01925	3.89e-17	75.9	COG2967@1|root,COG2967@2|Bacteria,1MZ2Z@1224|Proteobacteria,2U9JM@28211|Alphaproteobacteria,43K4K@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	protein affecting Mg2 Co2 transport	apaG	-	-	ko:K06195	-	-	-	-	ko00000	-	-	-	DUF525
k59_1228159_2	1244869.H261_08768	1.81e-73	226.0	COG0302@1|root,COG0302@2|Bacteria,1MY3N@1224|Proteobacteria,2TSZI@28211|Alphaproteobacteria,2JPKI@204441|Rhodospirillales	204441|Rhodospirillales	H	GTP cyclohydrolase	folE	-	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
k59_727548_1	96561.Dole_1610	3.39e-29	119.0	COG0365@1|root,COG0365@2|Bacteria,1MUX7@1224|Proteobacteria,42P5R@68525|delta/epsilon subdivisions,2WJDU@28221|Deltaproteobacteria,2MI4P@213118|Desulfobacterales	28221|Deltaproteobacteria	I	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.16	ko:K01907	ko00280,ko00650,map00280,map00650	-	R01357	RC00004,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_1616715_1	745718.JADT01000003_gene2272	4.23e-104	327.0	COG4447@1|root,COG4447@2|Bacteria,4NESU@976|Bacteroidetes,1HXIG@117743|Flavobacteriia	976|Bacteroidetes	G	BNR Asp-box repeat	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
k59_60264_1	591158.SSMG_04889	9.67e-06	52.0	COG0697@1|root,COG0697@2|Bacteria,2GKVT@201174|Actinobacteria	201174|Actinobacteria	EG	Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_1728005_1	562970.Btus_0472	7.74e-72	231.0	COG1541@1|root,COG1541@2|Bacteria,1TQA1@1239|Firmicutes	1239|Firmicutes	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
k59_1505566_1	926569.ANT_16840	2.53e-97	308.0	COG0013@1|root,COG0013@2|Bacteria,2G5KW@200795|Chloroflexi	200795|Chloroflexi	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
k59_560368_2	985255.APHJ01000040_gene357	1.04e-11	68.2	COG0563@1|root,COG0634@1|root,COG0563@2|Bacteria,COG0634@2|Bacteria,4NG7J@976|Bacteroidetes,1HWR5@117743|Flavobacteriia,2P62I@244698|Gillisia	976|Bacteroidetes	F	Adenylate kinase	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,Pribosyltran
k59_1116774_1	926569.ANT_10860	5.25e-70	237.0	COG0086@1|root,COG0086@2|Bacteria,2G632@200795|Chloroflexi	200795|Chloroflexi	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_449549_1	1385935.N836_24565	9.84e-10	58.2	COG2963@1|root,COG2963@2|Bacteria,1GAKB@1117|Cyanobacteria	1117|Cyanobacteria	L	IMG reference gene	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
k59_727557_1	177437.HRM2_44710	6.41e-185	531.0	COG1321@1|root,COG1321@2|Bacteria,1N8WG@1224|Proteobacteria	1224|Proteobacteria	K	iron dependent repressor	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_671919_2	1192034.CAP_0863	3.61e-15	79.0	COG1266@1|root,COG1266@2|Bacteria,1R5BW@1224|Proteobacteria,434JF@68525|delta/epsilon subdivisions,2WYWP@28221|Deltaproteobacteria,2Z0TD@29|Myxococcales	28221|Deltaproteobacteria	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
k59_449566_1	411474.COPEUT_01598	1.35e-35	131.0	COG0413@1|root,COG0413@2|Bacteria,1TPZA@1239|Firmicutes,248RR@186801|Clostridia	186801|Clostridia	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
k59_282768_1	926569.ANT_20830	5.67e-31	120.0	COG1893@1|root,COG1893@2|Bacteria,2G718@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
k59_1283360_1	525904.Tter_0950	2.51e-71	236.0	COG0173@1|root,COG0173@2|Bacteria,2NNP3@2323|unclassified Bacteria	2|Bacteria	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
k59_1172111_1	1120953.AUBH01000008_gene277	1.45e-61	198.0	COG3588@1|root,COG3588@2|Bacteria,1MVFK@1224|Proteobacteria,1RPMI@1236|Gammaproteobacteria,466BS@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	aldolase	fda	-	4.1.2.13	ko:K01623	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000,ko03036,ko04131,ko04147	-	-	-	Glycolytic
k59_1172118_1	349521.HCH_05018	2.37e-54	183.0	COG1020@1|root,COG1020@2|Bacteria,1N7HY@1224|Proteobacteria,1RQJX@1236|Gammaproteobacteria,1XN2U@135619|Oceanospirillales	135619|Oceanospirillales	Q	Protein of unknown function (DUF1298)	atfA1	-	2.3.1.20	ko:K00635	ko00561,ko01100,map00561,map01100	M00089	R02251	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1298,WES_acyltransf
k59_284460_1	566466.NOR53_3309	8.22e-46	165.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,1RNQM@1236|Gammaproteobacteria,1J4IR@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis	ubiB	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901576,GO:1901661,GO:1901663	-	ko:K03688	-	-	-	-	ko00000	-	-	iYL1228.KPN_04331	ABC1
k59_1507418_1	861299.J421_0087	2.26e-52	177.0	COG0387@1|root,COG0387@2|Bacteria	2|Bacteria	P	calcium:proton antiporter activity	cax	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006816,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015085,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015368,GO:0015369,GO:0015491,GO:0015672,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051139,GO:0051179,GO:0051234,GO:0055085,GO:0070588,GO:0070838,GO:0071944,GO:0072511,GO:0098655,GO:0098660,GO:0098662,GO:0099516,GO:1902600	-	ko:K07300	-	-	-	-	ko00000,ko02000	2.A.19	-	iJN678.slr1336	Na_Ca_ex
k59_673699_2	1232437.KL661966_gene3153	1.39e-14	71.6	COG1917@1|root,COG1917@2|Bacteria,1N2JS@1224|Proteobacteria,42TR3@68525|delta/epsilon subdivisions,2WQ4M@28221|Deltaproteobacteria,2MKQJ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_451337_1	861299.J421_2799	3.9e-84	258.0	COG0180@1|root,COG0180@2|Bacteria,1ZT3P@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	tRNA synthetases class I (W and Y)	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
k59_451337_2	1449355.JQNR01000004_gene1456	3.12e-08	56.6	COG0483@1|root,COG0483@2|Bacteria,2GP74@201174|Actinobacteria	201174|Actinobacteria	G	inositol monophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Inositol_P
k59_1396262_1	1521187.JPIM01000131_gene1453	2.61e-22	93.6	COG0824@1|root,COG0824@2|Bacteria,2G7HH@200795|Chloroflexi,377ME@32061|Chloroflexia	32061|Chloroflexia	S	PFAM thioesterase superfamily protein	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT_2
k59_62005_1	880073.Calab_0341	6.55e-93	286.0	COG2986@1|root,COG2986@2|Bacteria,2NQHF@2323|unclassified Bacteria	2|Bacteria	E	Aromatic amino acid lyase	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
k59_673721_1	471854.Dfer_2955	0.0004	48.5	COG0451@1|root,COG0451@2|Bacteria,4NFZH@976|Bacteroidetes,47M93@768503|Cytophagia	976|Bacteroidetes	M	PFAM NAD dependent epimerase dehydratase family	-	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase,NAD_binding_4
k59_729399_1	1121930.AQXG01000005_gene652	5.14e-33	127.0	COG0696@1|root,COG0696@2|Bacteria,4PND7@976|Bacteroidetes	976|Bacteroidetes	G	Metalloenzyme superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Metalloenzyme
k59_1575038_2	639030.JHVA01000001_gene1245	3.34e-10	64.3	COG0805@1|root,COG0805@2|Bacteria,3Y3UC@57723|Acidobacteria,2JISU@204432|Acidobacteriia	204432|Acidobacteriia	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
k59_1464145_1	296591.Bpro_4186	2.28e-19	87.8	COG4221@1|root,COG4221@2|Bacteria,1QYJ6@1224|Proteobacteria,2WHFZ@28216|Betaproteobacteria,4AJWZ@80864|Comamonadaceae	28216|Betaproteobacteria	S	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_296532_1	356851.JOAN01000001_gene3421	5.75e-12	70.9	COG0477@1|root,COG0477@2|Bacteria,2GJ09@201174|Actinobacteria,4D8TI@85008|Micromonosporales	201174|Actinobacteria	P	drug resistance transporter, EmrB QacA subfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_797081_1	1158146.KB907123_gene809	2.61e-06	52.4	COG1403@1|root,COG1403@2|Bacteria,1MWEQ@1224|Proteobacteria,1S2R0@1236|Gammaproteobacteria,1WWXG@135613|Chromatiales	135613|Chromatiales	L	PFAM HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH_5
k59_797081_2	926569.ANT_03310	3.36e-06	48.1	COG0065@1|root,COG0065@2|Bacteria,2G68G@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	-	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
k59_851568_1	228410.NE1321	6.43e-85	257.0	COG1183@1|root,COG1183@2|Bacteria,1MWD9@1224|Proteobacteria,2VIME@28216|Betaproteobacteria,3725D@32003|Nitrosomonadales	28216|Betaproteobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pssA	-	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_transf
k59_1243140_1	338963.Pcar_3003	1.65e-47	173.0	COG1538@1|root,COG1538@2|Bacteria,1MYXE@1224|Proteobacteria,42TA7@68525|delta/epsilon subdivisions,2WR7T@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_741534_1	1123073.KB899241_gene2498	8.76e-22	92.0	COG0204@1|root,COG0204@2|Bacteria,1RJMS@1224|Proteobacteria,1S71V@1236|Gammaproteobacteria,1X64J@135614|Xanthomonadales	135614|Xanthomonadales	I	Acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
k59_464134_1	29540.C481_01957	2.14e-11	63.9	COG2217@1|root,arCOG01576@2157|Archaea,2XT3T@28890|Euryarchaeota,23S6X@183963|Halobacteria	183963|Halobacteria	P	copper-translocating P-type ATPase	-	-	3.6.3.4	ko:K01533	-	-	R00086	RC00002	ko00000,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase
k59_351472_1	926569.ANT_14510	7.26e-42	154.0	COG1529@1|root,COG1529@2|Bacteria,2G5PH@200795|Chloroflexi	200795|Chloroflexi	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_629393_1	195105.CN97_15380	2.17e-13	74.7	2A1MP@1|root,30PVX@2|Bacteria,1R4FS@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_963808_1	530564.Psta_1731	5.38e-30	122.0	COG0577@1|root,COG0577@2|Bacteria,2IYHP@203682|Planctomycetes	203682|Planctomycetes	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_1408529_1	309801.trd_A0452	5.94e-47	164.0	COG0436@1|root,COG0436@2|Bacteria,2G5MC@200795|Chloroflexi,27YSW@189775|Thermomicrobia	189775|Thermomicrobia	E	Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
k59_851597_1	1266845.Q783_11040	7.75e-96	290.0	COG0050@1|root,COG0050@2|Bacteria,1TPKC@1239|Firmicutes,4HAEH@91061|Bacilli,27F8K@186828|Carnobacteriaceae	91061|Bacilli	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	iSB619.SA_RS02960	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
k59_1352850_1	439235.Dalk_2165	8.45e-15	79.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MRH@68525|delta/epsilon subdivisions,2WM8D@28221|Deltaproteobacteria,2MMH4@213118|Desulfobacterales	28221|Deltaproteobacteria	T	histidine kinase HAMP region domain protein	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,sCache_3_3
k59_407840_1	234267.Acid_4580	1.09e-56	193.0	COG1680@1|root,COG1680@2|Bacteria	2|Bacteria	V	peptidase activity	dap	-	3.4.11.19	ko:K01266	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Beta-lactamase,DAP_B
k59_1131119_1	357808.RoseRS_2049	8.09e-69	219.0	COG1980@1|root,COG1980@2|Bacteria,2G63P@200795|Chloroflexi	200795|Chloroflexi	G	Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P)	fbp	-	3.1.3.11,4.1.2.13	ko:K01622	ko00010,ko00030,ko00051,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00003	R00762,R01068,R01070,R02568,R04780	RC00017,RC00438,RC00439	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_3
k59_1741745_1	933262.AXAM01000163_gene2962	1.16e-11	67.8	COG1226@1|root,302MR@2|Bacteria,1N49G@1224|Proteobacteria,42X9E@68525|delta/epsilon subdivisions,2WTDX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
k59_241032_1	1379698.RBG1_1C00001G1548	7.83e-31	115.0	COG0454@1|root,COG0456@2|Bacteria,2NPTV@2323|unclassified Bacteria	2|Bacteria	K	This enzyme acetylates the N-terminal alanine of ribosomal protein S18	rimI	-	2.3.1.128	ko:K03789,ko:K14742	-	-	-	-	ko00000,ko01000,ko03009,ko03016	-	-	-	Acetyltransf_1,Acetyltransf_10
k59_1185985_1	1051632.TPY_1667	2.25e-30	118.0	COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,247UB@186801|Clostridia,3WCDK@538999|Clostridiales incertae sedis	186801|Clostridia	C	PFAM Acyl-CoA dehydrogenase, C-terminal domain	bcd	-	1.3.8.1	ko:K00248	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_1185985_2	861299.J421_3004	5.43e-30	115.0	COG0334@1|root,COG0334@2|Bacteria,1ZTBQ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase	-	-	1.4.1.9	ko:K00263	ko00280,ko00290,ko01100,ko01110,ko01130,map00280,map00290,map01100,map01110,map01130	-	R01088,R01434,R02196	RC00006,RC00036	ko00000,ko00001,ko01000	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
k59_741576_1	316274.Haur_3116	4.79e-49	168.0	COG1131@1|root,COG1131@2|Bacteria,2G890@200795|Chloroflexi,374U5@32061|Chloroflexia	32061|Chloroflexia	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1074673_1	113395.AXAI01000054_gene1971	1.4e-97	293.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1MW7X@1224|Proteobacteria,2U9ZP@28211|Alphaproteobacteria,3K0MT@41294|Bradyrhizobiaceae	1224|Proteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_28,HTH_32
k59_18797_2	479434.Sthe_1081	4.18e-96	293.0	COG1131@1|root,COG1131@2|Bacteria,2G6B8@200795|Chloroflexi	200795|Chloroflexi	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1074674_1	1111729.ATYV01000035_gene2404	0.00011	49.3	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,2GN50@201174|Actinobacteria,22M01@1653|Corynebacteriaceae	201174|Actinobacteria	P	Metallo-beta-lactamase superfamily	-	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B,Rhodanese
k59_1408583_1	1380394.JADL01000011_gene4035	7.66e-63	203.0	COG0119@1|root,COG0119@2|Bacteria,1MUMX@1224|Proteobacteria,2TT1R@28211|Alphaproteobacteria,2JVM1@204441|Rhodospirillales	204441|Rhodospirillales	E	HMGL-like	-	-	4.1.3.4	ko:K01640	ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146	M00036,M00088	R01360,R08090	RC00502,RC00503,RC01118,RC01946	ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
k59_1074675_1	1096546.WYO_2482	2.97e-39	149.0	COG0531@1|root,COG0531@2|Bacteria,1MXNJ@1224|Proteobacteria,2V1VM@28211|Alphaproteobacteria,1JXPE@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	Amino acid permease	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
k59_1019940_1	1340493.JNIF01000003_gene1450	1.44e-24	95.1	COG1695@1|root,COG1695@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	-	-	-	-	-	-	-	-	-	PadR
k59_1630034_1	190650.CC_3125	1.01e-37	142.0	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2U0BD@28211|Alphaproteobacteria,2KK0G@204458|Caulobacterales	204458|Caulobacterales	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_407886_1	1386969.AWTB01000093_gene4336	4.21e-06	51.2	COG2897@1|root,COG2897@2|Bacteria,2GMDR@201174|Actinobacteria,4GANW@85026|Gordoniaceae	201174|Actinobacteria	P	Rhodanese Homology Domain	sseB	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	ApbA,ApbA_C,Rhodanese
k59_963872_1	444157.Tneu_1020	6.39e-16	75.1	COG0494@1|root,arCOG01078@2157|Archaea	2157|Archaea	L	COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
k59_963872_2	1305737.JAFX01000001_gene2123	1.32e-14	73.6	COG0136@1|root,COG0136@2|Bacteria,4NE4V@976|Bacteroidetes,47JMK@768503|Cytophagia	976|Bacteroidetes	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
k59_1686488_1	420662.Mpe_A2227	2.8e-71	234.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2VHKU@28216|Betaproteobacteria,1KNDZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
k59_241069_1	1499683.CCFF01000013_gene324	3.3e-105	318.0	COG0252@1|root,COG0252@2|Bacteria,1TPP9@1239|Firmicutes,248F3@186801|Clostridia,36EB6@31979|Clostridiaceae	186801|Clostridia	EJ	L-asparaginase	-	-	3.5.1.1	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	-	R00485	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Asparaginase
k59_1575165_1	377629.TERTU_3372	9.01e-08	59.3	COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,1RNHR@1236|Gammaproteobacteria,2PQ0B@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	P	Outer membrane protein beta-barrel family	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k59_1686503_1	1449345.JHWC01000004_gene493	1.76e-20	92.4	COG0739@1|root,COG0739@2|Bacteria,1MY2X@1224|Proteobacteria,42U06@68525|delta/epsilon subdivisions,2YP2U@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	M	peptidase M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_241080_1	748247.AZKH_1450	9.64e-45	153.0	COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,2VM61@28216|Betaproteobacteria,2KW2G@206389|Rhodocyclales	206389|Rhodocyclales	K	LuxR family transcriptional regulator	-	-	-	ko:K13041	ko02020,map02020	M00514	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
k59_1519487_1	1265503.KB905161_gene3151	7.57e-58	201.0	COG3250@1|root,COG3250@2|Bacteria,1MVBN@1224|Proteobacteria,1RMER@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Belongs to the glycosyl hydrolase 2 family	-	-	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
k59_1519489_1	261292.Nit79A3_2626	5.99e-45	161.0	COG3225@1|root,COG3225@2|Bacteria,1MUXW@1224|Proteobacteria,2VMDE@28216|Betaproteobacteria,37263@32003|Nitrosomonadales	28216|Betaproteobacteria	N	ABC-type uncharacterized transport system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux
k59_963905_1	330214.NIDE2735	6.02e-51	176.0	COG1109@1|root,COG1109@2|Bacteria,3J0E7@40117|Nitrospirae	40117|Nitrospirae	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_296672_1	1278073.MYSTI_07864	1.2e-37	144.0	COG0577@1|root,COG0577@2|Bacteria,1NREW@1224|Proteobacteria	1224|Proteobacteria	V	COG0577 ABC-type antimicrobial peptide transport system permease component	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_185072_2	109760.SPPG_02967T0	3.66e-23	98.2	COG1999@1|root,KOG2792@2759|Eukaryota,38Q3U@33154|Opisthokonta,3NY20@4751|Fungi	4751|Fungi	C	Mitochondrial metallochaperone Sco1	SCO1	GO:0000041,GO:0003674,GO:0003824,GO:0004601,GO:0005488,GO:0005507,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006810,GO:0006811,GO:0006812,GO:0006825,GO:0006996,GO:0007005,GO:0008150,GO:0008152,GO:0008379,GO:0008535,GO:0009636,GO:0009987,GO:0016020,GO:0016043,GO:0016209,GO:0016491,GO:0016530,GO:0016531,GO:0016684,GO:0017004,GO:0019866,GO:0022607,GO:0030001,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0033108,GO:0033617,GO:0034622,GO:0042221,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043933,GO:0044085,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0051775,GO:0051920,GO:0055114,GO:0065003,GO:0070887,GO:0071840,GO:0097237,GO:0098754,GO:0098869,GO:0140104,GO:1990748	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC
k59_1464290_1	391038.Bphy_5324	3.87e-90	278.0	COG4962@1|root,COG4962@2|Bacteria,1R7EN@1224|Proteobacteria,2VJWJ@28216|Betaproteobacteria,1K2AA@119060|Burkholderiaceae	28216|Betaproteobacteria	U	type II secretion system protein E	cpaF1	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
k59_1630084_1	1123226.KB899311_gene1784	1.05e-12	72.0	COG1624@1|root,COG1624@2|Bacteria,1TPRW@1239|Firmicutes,4H9XZ@91061|Bacilli,26R2I@186822|Paenibacillaceae	91061|Bacilli	S	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria	dacA	GO:0003674,GO:0003824,GO:0004016,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0009975,GO:0016020,GO:0016021,GO:0016829,GO:0016849,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	2.7.7.85	ko:K18672	-	-	-	-	ko00000,ko01000	-	-	-	DisA_N
k59_963919_1	29495.EA26_00615	2.33e-41	154.0	COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,1RNR3@1236|Gammaproteobacteria,1XT5T@135623|Vibrionales	135623|Vibrionales	J	Glycyl-tRNA synthetase beta subunit	glyS	GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
k59_18857_1	930169.B5T_01667	2.12e-52	174.0	COG0235@1|root,COG0235@2|Bacteria,1MWP9@1224|Proteobacteria,1RQNI@1236|Gammaproteobacteria,1XHBZ@135619|Oceanospirillales	135619|Oceanospirillales	G	COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II
k59_296683_2	861299.J421_2404	4.04e-16	80.9	2DW4B@1|root,33YGG@2|Bacteria,1ZV12@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1464306_1	86416.Clopa_0157	9.84e-27	111.0	COG1149@1|root,COG1149@2|Bacteria,1UI75@1239|Firmicutes,25EC8@186801|Clostridia,36UK4@31979|Clostridiaceae	186801|Clostridia	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_7
k59_1519523_1	546269.HMPREF0389_00503	4.04e-60	202.0	COG1418@1|root,COG1418@2|Bacteria,1TP48@1239|Firmicutes,248G8@186801|Clostridia,25R0R@186804|Peptostreptococcaceae	186801|Clostridia	S	Endoribonuclease that initiates mRNA decay	rny	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
k59_129102_1	1121033.AUCF01000005_gene5149	1.38e-55	192.0	COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,2TQXN@28211|Alphaproteobacteria,2JQSS@204441|Rhodospirillales	204441|Rhodospirillales	E	aminopeptidase	pepP	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Creatinase_N_2,Peptidase_M24,Peptidase_M24_C
k59_18880_1	1449063.JMLS01000024_gene3674	6.54e-13	73.6	COG2358@1|root,COG2358@2|Bacteria,1TPXW@1239|Firmicutes,4HB7U@91061|Bacilli,26ZXE@186822|Paenibacillaceae	91061|Bacilli	S	NMT1-like family	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
k59_1186087_1	543632.JOJL01000084_gene1908	9.83e-56	198.0	COG2319@1|root,COG2319@2|Bacteria,2GJN3@201174|Actinobacteria,4D8IB@85008|Micromonosporales	201174|Actinobacteria	O	WD-40 repeat	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31,WD40
k59_574031_2	926550.CLDAP_00290	6.81e-28	111.0	COG1070@1|root,COG1070@2|Bacteria,2G5QX@200795|Chloroflexi	200795|Chloroflexi	G	PFAM carbohydrate kinase	xylB	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
k59_20670_1	67281.JNZZ01000013_gene1791	5.19e-36	138.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,2GKXV@201174|Actinobacteria,4197R@629295|Streptomyces griseus group	201174|Actinobacteria	C	Pyruvate:ferredoxin oxidoreductase core domain II	korA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
k59_20670_2	983920.Y88_0551	5.21e-11	62.4	COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,2TR4R@28211|Alphaproteobacteria,2K1JI@204457|Sphingomonadales	204457|Sphingomonadales	C	COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, beta subunit	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
k59_631237_1	1347087.CBYO010000007_gene1158	6.53e-59	194.0	COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,4HA4E@91061|Bacilli	91061|Bacilli	P	Belongs to the ABC transporter superfamily	dppD	-	-	ko:K16202	ko02010,map02010	M00566	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.2	-	-	ABC_tran,oligo_HPY
k59_1299163_1	1461693.ATO10_07932	3.1e-87	263.0	COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,2TSH9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
k59_20676_2	714961.BFZC1_10060	7.1e-12	66.6	COG0260@1|root,COG0260@2|Bacteria,1TPJZ@1239|Firmicutes,4HAPW@91061|Bacilli,3IWSJ@400634|Lysinibacillus	91061|Bacilli	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
k59_743495_1	1201292.DR75_2106	2.43e-05	52.4	COG0737@1|root,COG0737@2|Bacteria,1TPV2@1239|Firmicutes,4H9VJ@91061|Bacilli,4B1BN@81852|Enterococcaceae	91061|Bacilli	F	5'-nucleotidase, C-terminal domain	-	-	3.1.3.5,3.1.3.6,3.1.4.16	ko:K01081,ko:K01119	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01562,R01569,R01664,R01877,R01968,R02088,R02102,R02148,R02323,R02370,R02719,R03346,R03537,R03538,R03929,R05135	RC00017,RC00078,RC00296	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,Metallophos
k59_1021898_2	926569.ANT_04460	5.57e-35	125.0	COG1853@1|root,COG1853@2|Bacteria,2G6XG@200795|Chloroflexi	200795|Chloroflexi	S	PFAM flavin reductase domain protein, FMN-binding	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
k59_186962_1	1235803.C825_00297	2.12e-21	98.6	COG0673@1|root,COG0673@2|Bacteria,4NF4Q@976|Bacteroidetes,2FQ86@200643|Bacteroidia,22X9Z@171551|Porphyromonadaceae	976|Bacteroidetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_1076720_1	518766.Rmar_0598	3.43e-69	228.0	COG0449@1|root,COG0449@2|Bacteria,4NE8Q@976|Bacteroidetes,1FIV2@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
k59_242877_1	481448.Minf_1414	1.31e-44	160.0	COG0770@1|root,COG0770@2|Bacteria,46SDF@74201|Verrucomicrobia,37G31@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_298587_1	1116375.VEJY3_14640	8.61e-13	70.9	COG2264@1|root,COG2264@2|Bacteria,1MUPC@1224|Proteobacteria,1RNAR@1236|Gammaproteobacteria,1XTMC@135623|Vibrionales	135623|Vibrionales	J	Methylates ribosomal protein L11	prmA	-	-	ko:K02687	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PrmA
k59_575999_1	1125863.JAFN01000001_gene2902	1.16e-69	223.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,42NES@68525|delta/epsilon subdivisions,2WJ0V@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NU	Type II secretion system	pilC	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
k59_1299211_1	1123075.AUDP01000003_gene616	9.77e-06	46.2	COG1917@1|root,COG1917@2|Bacteria,1VGJQ@1239|Firmicutes,25EGC@186801|Clostridia,3WSQC@541000|Ruminococcaceae	186801|Clostridia	S	Cupin domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_1743633_1	379066.GAU_0457	5.54e-85	274.0	COG0480@1|root,COG0480@2|Bacteria,1ZTFA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Elongation factor G, domain IV	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU
k59_1589919_1	671065.MetMK1DRAFT_00015940	1.32e-41	154.0	COG0028@1|root,arCOG03657@2157|Archaea	2157|Archaea	EH	thiamine pyrophosphate binding	-	-	-	-	-	-	-	-	-	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_811526_1	1122622.ATWJ01000009_gene3142	2.68e-65	224.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,2GJKW@201174|Actinobacteria,4FIUY@85021|Intrasporangiaceae	201174|Actinobacteria	M	Peptidase family S41	tri1	GO:0003674,GO:0003824,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0043170,GO:0044238,GO:0070011,GO:0071704,GO:0140096,GO:1901564	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
k59_1312786_1	639283.Snov_0539	1.33e-31	122.0	COG1679@1|root,COG1679@2|Bacteria,1NFH4@1224|Proteobacteria,2TTR6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF521)	-	-	-	ko:K09123	-	-	-	-	ko00000	-	-	-	DUF521
k59_1312786_2	1267005.KB911257_gene1167	5.28e-16	73.9	COG1786@1|root,COG1786@2|Bacteria,1RFUH@1224|Proteobacteria,2USWD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function DUF126	-	-	-	ko:K09128	-	-	-	-	ko00000	-	-	-	DUF126
k59_311806_1	1259795.ARJK01000003_gene1121	6.92e-06	48.5	COG2703@1|root,COG2703@2|Bacteria,1VAI0@1239|Firmicutes,24MQU@186801|Clostridia	186801|Clostridia	P	Hemerythrin HHE cation binding domain	-	-	-	ko:K07216	-	-	-	-	ko00000	-	-	-	Hemerythrin
k59_311806_2	1380394.JADL01000002_gene1408	6.3e-66	217.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,2TS07@28211|Alphaproteobacteria,2JPIQ@204441|Rhodospirillales	28211|Alphaproteobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
k59_1643549_1	1128421.JAGA01000001_gene2048	6.57e-89	268.0	COG1611@1|root,COG1611@2|Bacteria,2NP7M@2323|unclassified Bacteria	2|Bacteria	S	Possible lysine decarboxylase	yvdD_2	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
k59_1312789_1	861299.J421_3441	7.65e-75	240.0	COG1418@1|root,COG1418@2|Bacteria,1ZT0I@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Endoribonuclease that initiates mRNA decay	rny	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
k59_811531_1	177437.HRM2_19220	3.71e-122	367.0	COG4584@1|root,COG4584@2|Bacteria	2|Bacteria	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	HTH_38,HTH_7,rve
k59_1035784_1	1068978.AMETH_3665	4.3e-22	100.0	COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	pdhB	GO:0003674,GO:0005488,GO:0005515,GO:0140030,GO:0140032	1.2.4.1	ko:K00161,ko:K00162,ko:K21417	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS05355,iYO844.BSU14590	E1_dh,Transket_pyr,Transketolase_C
k59_479777_1	1380394.JADL01000009_gene3408	8.93e-39	134.0	COG4032@1|root,COG4032@2|Bacteria,1P0HU@1224|Proteobacteria,2TRJ2@28211|Alphaproteobacteria,2JS9A@204441|Rhodospirillales	204441|Rhodospirillales	S	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain	-	-	-	-	-	-	-	-	-	-	-	-	TPP_enzyme_N
k59_588351_1	1479238.JQMZ01000001_gene490	5.94e-08	50.4	2EDFV@1|root,337C2@2|Bacteria,1NEHC@1224|Proteobacteria,2UGDN@28211|Alphaproteobacteria,4403D@69657|Hyphomonadaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1702223_1	671143.DAMO_3102	5.84e-78	246.0	COG0104@1|root,COG0104@2|Bacteria,2NNYU@2323|unclassified Bacteria	2|Bacteria	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046033,GO:0046040,GO:0046085,GO:0046086,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	iECNA114_1301.ECNA114_4393,iECSF_1327.ECSF_4063,iJN746.PP_4889	Adenylsucc_synt
k59_366152_2	1183438.GKIL_2935	5.89e-23	100.0	COG1680@1|root,COG1680@2|Bacteria,1G434@1117|Cyanobacteria	1117|Cyanobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_865654_1	323848.Nmul_A1018	2.9e-107	337.0	COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,2VJYV@28216|Betaproteobacteria,373XN@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdop_Fe4S4,Molybdopterin,NADH-G_4Fe-4S_3
k59_366158_1	555079.Toce_0558	3.56e-07	50.1	COG4576@1|root,COG4576@2|Bacteria,1VEI4@1239|Firmicutes,24QJA@186801|Clostridia,42HKJ@68295|Thermoanaerobacterales	186801|Clostridia	CQ	Ethanolamine utilisation protein EutN/carboxysome	ccmL	-	-	ko:K04028	-	-	-	-	ko00000	-	-	-	EutN_CcmL
k59_366158_2	1191523.MROS_0181	4.37e-28	104.0	COG4576@1|root,COG4576@2|Bacteria	2|Bacteria	CQ	ethanolamine utilization protein EutN carboxysome structural protein Ccml	eutN	-	-	ko:K04028	-	-	-	-	ko00000	-	-	-	EutN_CcmL
k59_32755_1	1123405.AUMM01000021_gene2977	6.04e-71	233.0	COG0129@1|root,COG0129@2|Bacteria,1TP1R@1239|Firmicutes,4H9ZG@91061|Bacilli,26NCF@186821|Sporolactobacillaceae	91061|Bacilli	EG	Dehydratase family	-	-	-	-	-	-	-	-	-	-	-	-	ILVD_EDD
k59_979432_1	211114.JOEF01000026_gene358	5.58e-21	89.0	2DBMA@1|root,2Z9Y3@2|Bacteria,2I9ER@201174|Actinobacteria,4E2VY@85010|Pseudonocardiales	201174|Actinobacteria	S	Domain of unknown function (DUF4389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4389
k59_254780_1	1323663.AROI01000015_gene548	3.89e-69	219.0	COG2801@1|root,COG2801@2|Bacteria,1MWNX@1224|Proteobacteria,1RQHG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,LZ_Tnp_IS481,rve
k59_1702266_1	1231391.AMZF01000010_gene1690	6.05e-26	100.0	COG0479@1|root,COG0479@2|Bacteria	2|Bacteria	C	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family	-	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer2_4
k59_1755155_1	1379270.AUXF01000006_gene130	7.81e-09	56.6	COG1185@1|root,COG1185@2|Bacteria,1ZT7C@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
k59_1755155_2	1246995.AFR_35905	1.32e-26	110.0	COG0612@1|root,COG0612@2|Bacteria,2GJZ3@201174|Actinobacteria,4D8I3@85008|Micromonosporales	201174|Actinobacteria	S	Belongs to the peptidase M16 family	pepR	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_979453_1	439235.Dalk_2209	3.37e-34	132.0	COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,42NUP@68525|delta/epsilon subdivisions,2WKSD@28221|Deltaproteobacteria,2MNKG@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Mechanosensitive ion channel	mscS-1	-	-	ko:K16052	-	-	-	-	ko00000,ko02000	1.A.23.4	-	-	MS_channel
k59_32783_1	1123024.AUII01000003_gene3293	2.34e-14	79.3	COG1331@1|root,COG1331@2|Bacteria,2GJ88@201174|Actinobacteria,4DYTK@85010|Pseudonocardiales	201174|Actinobacteria	O	Highly conserved protein containing a thioredoxin domain	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
k59_1257980_1	1121019.AUMN01000001_gene511	2.37e-28	112.0	COG0834@1|root,COG0834@2|Bacteria,2GJQW@201174|Actinobacteria	201174|Actinobacteria	ET	Belongs to the bacterial solute-binding protein 3 family	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
k59_979467_1	616991.JPOO01000003_gene2646	1.22e-101	302.0	COG0407@1|root,COG0407@2|Bacteria,4NEQ7@976|Bacteroidetes,1HY0P@117743|Flavobacteriia,23GGU@178469|Arenibacter	976|Bacteroidetes	H	Uroporphyrinogen decarboxylase (URO-D)	hemE	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
k59_88500_1	1035308.AQYY01000001_gene1943	5.3e-95	294.0	COG0365@1|root,COG0365@2|Bacteria,1TQTI@1239|Firmicutes,24BRX@186801|Clostridia,260H8@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_1200530_1	1121904.ARBP01000010_gene2226	2.35e-52	187.0	COG0841@1|root,COG0841@2|Bacteria,4NDZG@976|Bacteroidetes,47ME1@768503|Cytophagia	976|Bacteroidetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1479157_1	1121904.ARBP01000066_gene2202	1.21e-40	155.0	COG3464@1|root,COG3464@2|Bacteria,4NN8R@976|Bacteroidetes,47SSX@768503|Cytophagia	976|Bacteroidetes	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,zf-ISL3
k59_533451_1	1121422.AUMW01000020_gene1732	2.1e-72	231.0	COG1960@1|root,COG1960@2|Bacteria,1UYXJ@1239|Firmicutes,25BWS@186801|Clostridia,264HJ@186807|Peptococcaceae	186801|Clostridia	I	Acyl-CoA dehydrogenase, N-terminal domain	-	-	-	ko:K11731	ko00281,map00281	-	R08089	RC01893	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_811615_1	880073.Calab_3693	1.67e-59	206.0	COG1297@1|root,COG1297@2|Bacteria,2NPP0@2323|unclassified Bacteria	2|Bacteria	S	OPT oligopeptide transporter protein	oliA	GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0008150,GO:0016020,GO:0022857,GO:0051179,GO:0051234,GO:0055085	-	-	-	-	-	-	-	-	-	-	OPT
k59_1035872_1	96561.Dole_3250	4.4e-98	302.0	COG3039@1|root,COG3039@2|Bacteria,1QQ9Q@1224|Proteobacteria,42S7X@68525|delta/epsilon subdivisions,2WNJ2@28221|Deltaproteobacteria,2MJG4@213118|Desulfobacterales	28221|Deltaproteobacteria	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
k59_88516_2	1120970.AUBZ01000007_gene2980	1.19e-20	89.7	COG2231@1|root,COG2231@2|Bacteria,1RDJ8@1224|Proteobacteria,1RUHP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	HhH-GPD family	-	-	-	ko:K07457	-	-	-	-	ko00000	-	-	-	HhH-GPD
k59_1146020_1	358220.C380_17385	1.66e-79	245.0	COG0411@1|root,COG0411@2|Bacteria,1MVAU@1224|Proteobacteria,2VP5B@28216|Betaproteobacteria,4AAZV@80864|Comamonadaceae	28216|Betaproteobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
k59_1146020_2	1458275.AZ34_07625	1.59e-06	50.1	COG4177@1|root,COG4177@2|Bacteria,1NPII@1224|Proteobacteria,2VNRM@28216|Betaproteobacteria,4AAJ7@80864|Comamonadaceae	28216|Betaproteobacteria	P	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_422251_1	1131269.AQVV01000015_gene2005	2.56e-27	109.0	COG2802@1|root,COG2802@2|Bacteria	2|Bacteria	S	histone H2A-K13 ubiquitination	lonD	-	3.4.21.53	ko:K01338,ko:K07157	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	LON_substr_bdg
k59_924916_1	626887.J057_01124	1.92e-45	154.0	2E4B7@1|root,32Z6X@2|Bacteria,1N8XS@1224|Proteobacteria,1SENM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF2846)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2846
k59_865764_1	926569.ANT_00730	2.8e-10	67.4	COG1287@1|root,COG1287@2|Bacteria,2G9P1@200795|Chloroflexi	200795|Chloroflexi	S	oligosaccharyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
k59_1422937_1	926569.ANT_06390	1.44e-97	294.0	COG1216@1|root,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glycos_transf_2
k59_1367819_1	1121918.ARWE01000001_gene698	1.93e-43	157.0	COG0534@1|root,COG0534@2|Bacteria,1R3WH@1224|Proteobacteria,42Q54@68525|delta/epsilon subdivisions,2WM10@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	Mate efflux family protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1035926_1	1380394.JADL01000001_gene2045	3.99e-122	358.0	COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,2TUWG@28211|Alphaproteobacteria,2JQ92@204441|Rhodospirillales	204441|Rhodospirillales	EP	N-terminal TM domain of oligopeptide transport permease C	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
k59_422305_1	393305.YE3072	1.76e-52	179.0	COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,1RMU8@1236|Gammaproteobacteria,41DE0@629|Yersinia	1236|Gammaproteobacteria	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III	manB	-	5.4.2.8	ko:K01840	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01818	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_1258087_1	1206744.BAGL01000126_gene6190	1.02e-33	134.0	COG3055@1|root,COG3055@2|Bacteria,2GK14@201174|Actinobacteria,4FUXU@85025|Nocardiaceae	201174|Actinobacteria	Q	Domain of unknown function (DUF1929)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1929,FG-GAP,VCBS
k59_811693_1	379731.PST_2712	1.34e-46	162.0	COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria,1RNWH@1236|Gammaproteobacteria,1Z11G@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	T	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	cusR	GO:0000160,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0006355,GO:0007154,GO:0007165,GO:0008150,GO:0009889,GO:0009893,GO:0009987,GO:0010035,GO:0010038,GO:0010468,GO:0010556,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0023052,GO:0031323,GO:0031326,GO:0035556,GO:0042221,GO:0042802,GO:0046688,GO:0048518,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	ko:K07665	ko02020,map02020	M00452,M00745	-	-	ko00000,ko00001,ko00002,ko01504,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_1702411_1	479435.Kfla_3515	2.65e-60	211.0	COG3696@1|root,COG3696@2|Bacteria,2H303@201174|Actinobacteria,4DWUS@85009|Propionibacteriales	201174|Actinobacteria	P	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1755271_1	1121934.AUDX01000005_gene141	2.81e-35	139.0	COG4585@1|root,COG4585@2|Bacteria,2HDZV@201174|Actinobacteria,4FQ2J@85023|Microbacteriaceae	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
k59_422321_1	156889.Mmc1_1775	0.00088	40.8	COG0828@1|root,COG0828@2|Bacteria,1MZA1@1224|Proteobacteria,2UC58@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Belongs to the bacterial ribosomal protein bS21 family	rpsU	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904	-	ko:K02970	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S21
k59_701336_1	991905.SL003B_2852	6.33e-32	123.0	COG3618@1|root,COG3618@2|Bacteria,1N2QM@1224|Proteobacteria,2TTZK@28211|Alphaproteobacteria,4BQHN@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Amidohydrolase	ligI	-	3.1.1.57	ko:K10221	ko00362,ko00627,ko01120,map00362,map00627,map01120	-	R04277	RC03110	ko00000,ko00001,ko01000	-	-	-	Amidohydro_2
k59_90470_1	1437448.AZRT01000188_gene4157	2.68e-67	214.0	COG4663@1|root,COG4663@2|Bacteria,1MUA1@1224|Proteobacteria,2TQS2@28211|Alphaproteobacteria,1J3Y4@118882|Brucellaceae	28211|Alphaproteobacteria	Q	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_256738_2	32057.KB217478_gene2498	5.28e-05	48.1	COG0426@1|root,COG1853@1|root,COG0426@2|Bacteria,COG1853@2|Bacteria,1GBVN@1117|Cyanobacteria,1HM2G@1161|Nostocales	1117|Cyanobacteria	C	flavodoxin nitric oxide synthase	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct,Flavodoxin_1
k59_1260071_1	483219.LILAB_00295	2.4e-48	176.0	COG2937@1|root,COG3320@1|root,COG3774@1|root,COG2937@2|Bacteria,COG3320@2|Bacteria,COG3774@2|Bacteria	2|Bacteria	M	pathogenesis	plsB	-	2.3.1.15,6.2.1.3	ko:K00631,ko:K01897	ko00061,ko00071,ko00561,ko00564,ko01100,ko01110,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map00561,map00564,map01100,map01110,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086,M00089	R00851,R01280,R09380	RC00004,RC00014,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	Acyltransferase,NAD_binding_4,PS_pyruv_trans
k59_813499_2	749414.SBI_02970	6.74e-21	89.0	COG0842@1|root,COG0842@2|Bacteria,2GN6S@201174|Actinobacteria	201174|Actinobacteria	V	transport, permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
k59_1091864_2	1150399.AQYK01000002_gene2134	4.25e-62	197.0	COG2820@1|root,COG2820@2|Bacteria,2I5RQ@201174|Actinobacteria	201174|Actinobacteria	F	Phosphorylase superfamily	-	-	3.2.2.4	ko:K01241	ko00230,map00230	-	R00182	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
k59_424183_1	1211115.ALIQ01000244_gene3756	3.44e-46	153.0	COG2818@1|root,COG2818@2|Bacteria,1R9X5@1224|Proteobacteria,2TUP5@28211|Alphaproteobacteria,3NACR@45404|Beijerinckiaceae	28211|Alphaproteobacteria	L	Methyladenine glycosylase	tag	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
k59_424183_2	331869.BAL199_05369	4.21e-18	77.4	COG2350@1|root,COG2350@2|Bacteria,1PZSM@1224|Proteobacteria,2UGH8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	YCII
k59_1038157_1	1459636.NTE_02053	1.08e-71	226.0	COG1405@1|root,arCOG01981@2157|Archaea,41S8Y@651137|Thaumarchaeota	651137|Thaumarchaeota	K	factor TFIIB	-	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
k59_927194_1	1122221.JHVI01000020_gene1066	3.53e-138	405.0	COG0183@1|root,COG0183@2|Bacteria,1WIPU@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	Belongs to the thiolase family	-	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_1315307_1	1354722.JQLS01000001_gene4826	2.57e-22	96.7	COG0365@1|root,COG0654@1|root,COG0365@2|Bacteria,COG0654@2|Bacteria,1MUF5@1224|Proteobacteria,2TR3P@28211|Alphaproteobacteria,46RU9@74030|Roseovarius	28211|Alphaproteobacteria	I	AMP-binding enzyme C-terminal domain	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C,FAD_binding_3
k59_1315307_2	13616.ENSMODP00000019904	9.31e-19	89.0	COG0596@1|root,COG1011@1|root,KOG3085@2759|Eukaryota,KOG4178@2759|Eukaryota,39WAD@33154|Opisthokonta,3BACN@33208|Metazoa,3CVBC@33213|Bilateria,482KF@7711|Chordata,48X7C@7742|Vertebrata,3JCRV@40674|Mammalia,4K8JG@9263|Metatheria	33208|Metazoa	I	Haloacid dehalogenase-like hydrolase	EPHX2	GO:0000287,GO:0001676,GO:0002532,GO:0002538,GO:0002539,GO:0003008,GO:0003013,GO:0003018,GO:0003674,GO:0003824,GO:0004301,GO:0005102,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0005782,GO:0005829,GO:0006082,GO:0006605,GO:0006625,GO:0006629,GO:0006631,GO:0006633,GO:0006690,GO:0006725,GO:0006793,GO:0006796,GO:0006805,GO:0006810,GO:0006873,GO:0006874,GO:0006875,GO:0006886,GO:0006950,GO:0006952,GO:0006954,GO:0006996,GO:0007031,GO:0007600,GO:0008015,GO:0008104,GO:0008150,GO:0008152,GO:0008217,GO:0008610,GO:0009056,GO:0009058,GO:0009410,GO:0009636,GO:0009810,GO:0009893,GO:0009987,GO:0010468,GO:0010604,GO:0010628,GO:0015031,GO:0015643,GO:0015833,GO:0016043,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016801,GO:0016803,GO:0017144,GO:0018904,GO:0019216,GO:0019218,GO:0019222,GO:0019233,GO:0019369,GO:0019373,GO:0019439,GO:0019725,GO:0019752,GO:0030003,GO:0030258,GO:0031907,GO:0031974,GO:0032501,GO:0032787,GO:0033036,GO:0033365,GO:0033559,GO:0034613,GO:0035150,GO:0035296,GO:0042221,GO:0042577,GO:0042578,GO:0042579,GO:0042592,GO:0042632,GO:0042759,GO:0042802,GO:0042803,GO:0042886,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043574,GO:0043651,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044464,GO:0045184,GO:0045777,GO:0046272,GO:0046394,GO:0046483,GO:0046839,GO:0046872,GO:0046907,GO:0046983,GO:0048518,GO:0048878,GO:0050789,GO:0050801,GO:0050877,GO:0050880,GO:0050896,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0051716,GO:0055065,GO:0055074,GO:0055080,GO:0055082,GO:0055088,GO:0055092,GO:0060255,GO:0062012,GO:0065007,GO:0065008,GO:0070013,GO:0070727,GO:0070887,GO:0071466,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0072330,GO:0072503,GO:0072507,GO:0072593,GO:0072594,GO:0072662,GO:0072663,GO:0080090,GO:0090066,GO:0090181,GO:0097176,GO:0097746,GO:0097755,GO:0098771,GO:1900673,GO:1901360,GO:1901361,GO:1901568,GO:1901575,GO:1901576	3.1.3.76,3.3.2.10	ko:K08726,ko:K10089	ko00590,ko00625,ko01100,ko01120,ko04142,ko04145,ko04146,map00590,map00625,map01100,map01120,map04142,map04145,map04146	-	R05842,R07108,R07109,R07110,R07111	RC01477,RC01757	ko00000,ko00001,ko01000,ko01002,ko01009,ko04091,ko04147	-	-	-	Abhydrolase_1,HAD_2
k59_145489_1	298653.Franean1_0868	9.1e-19	87.8	COG1853@1|root,COG1853@2|Bacteria,2GMPH@201174|Actinobacteria	201174|Actinobacteria	K	PFAM flavin reductase domain protein, FMN-binding	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
k59_1038175_1	1521187.JPIM01000044_gene3305	1.25e-69	231.0	COG0205@1|root,COG0205@2|Bacteria,2G62R@200795|Chloroflexi,375FT@32061|Chloroflexia	32061|Chloroflexia	H	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	-	-	2.7.1.11	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
k59_1369836_1	253839.SSNG_05316	1.11e-52	179.0	COG2162@1|root,COG2162@2|Bacteria,2GP1R@201174|Actinobacteria	201174|Actinobacteria	Q	Belongs to the arylamine N-acetyltransferase family	-	-	2.3.1.118	ko:K00675	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_2
k59_424212_1	641524.ADICYQ_4692	1.11e-82	265.0	COG0793@1|root,COG0793@2|Bacteria,4NEK8@976|Bacteroidetes	976|Bacteroidetes	M	peptidase S41	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S41
k59_145498_1	1303518.CCALI_00140	1.02e-31	124.0	COG1619@1|root,COG1619@2|Bacteria	2|Bacteria	V	carboxypeptidase activity	ykfA	-	3.4.17.13	ko:K01297	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_S66
k59_314082_1	1095769.CAHF01000011_gene2629	6.27e-21	90.5	COG4662@1|root,COG4662@2|Bacteria,1MZVS@1224|Proteobacteria,2VNEC@28216|Betaproteobacteria,473P2@75682|Oxalobacteraceae	28216|Betaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	tupB	-	3.6.3.55	ko:K05773,ko:K06857	ko02010,map02010	M00186	R10531	RC00002	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	BPD_transp_1
k59_1481222_2	45351.EDO49390	2.17e-07	52.4	COG0647@1|root,KOG3040@2759|Eukaryota,38BE9@33154|Opisthokonta,3BAPU@33208|Metazoa	33208|Metazoa	G	Haloacid dehalogenase-like hydrolase	HDHD2	GO:0003674,GO:0003824,GO:0004427,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0010941,GO:0016311,GO:0016462,GO:0016787,GO:0016788,GO:0016791,GO:0016817,GO:0016818,GO:0019899,GO:0042578,GO:0042981,GO:0043067,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0065007,GO:2000269	-	-	-	-	-	-	-	-	-	-	Hydrolase_6,Hydrolase_like,Yos1
k59_314099_1	292459.STH3134	2.06e-16	82.8	COG3869@1|root,COG3869@2|Bacteria,1TPBA@1239|Firmicutes,247SS@186801|Clostridia	186801|Clostridia	H	Catalyzes the specific phosphorylation of arginine residues in proteins	mcsB	-	2.7.14.1	ko:K19405	-	-	R11090	RC00002,RC00203	ko00000,ko01000	-	-	-	ATP-gua_Ptrans
k59_1148068_1	1313172.YM304_18600	2.89e-08	56.2	COG0711@1|root,COG0711@2|Bacteria,2HG9T@201174|Actinobacteria,4CN89@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1148068_2	1385518.N798_04545	3.31e-28	106.0	COG0669@1|root,COG0669@2|Bacteria,2GN1S@201174|Actinobacteria,4FGNP@85021|Intrasporangiaceae	201174|Actinobacteria	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	GO:0003674,GO:0003824,GO:0004595,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016043,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0022607,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034214,GO:0034641,GO:0034654,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0055086,GO:0065003,GO:0070566,GO:0071704,GO:0071840,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
k59_1535820_2	384765.SIAM614_31266	4.35e-06	52.4	COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DZR,Guanylate_cyc,SAM_1,SAM_2
k59_314112_1	582744.Msip34_2231	8.23e-88	269.0	COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,2VIRX@28216|Betaproteobacteria,2KKC8@206350|Nitrosomonadales	206350|Nitrosomonadales	J	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
k59_880541_1	391625.PPSIR1_10990	4.81e-78	246.0	COG3464@1|root,COG3464@2|Bacteria,1MV5J@1224|Proteobacteria,42M93@68525|delta/epsilon subdivisions,2WK5I@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM Transposase, IS204 IS1001 IS1096 IS1165	-	-	-	ko:K07485	-	-	-	-	ko00000	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3
k59_1493639_1	1313421.JHBV01000043_gene3139	3.44e-93	295.0	COG4631@1|root,COG4631@2|Bacteria,4PMEG@976|Bacteroidetes,1IPUS@117747|Sphingobacteriia	976|Bacteroidetes	C	aldehyde oxidase and xanthine dehydrogenase a b hammerhead	-	-	1.17.1.4	ko:K13482	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_102579_1	1121927.GOHSU_17_00210	0.000153	49.3	COG1307@1|root,COG1307@2|Bacteria,2GIUV@201174|Actinobacteria,4GAKX@85026|Gordoniaceae	201174|Actinobacteria	S	Uncharacterised protein, DegV family COG1307	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DegV
k59_656089_1	1094980.Mpsy_0381	8.16e-49	176.0	COG5607@1|root,arCOG02827@1|root,arCOG02827@2157|Archaea,arCOG05139@2157|Archaea,2Y7EP@28890|Euryarchaeota,2NA8G@224756|Methanomicrobia	224756|Methanomicrobia	F	CHAD	-	-	-	-	-	-	-	-	-	-	-	-	CHAD,CYTH
k59_1160805_1	1121937.AUHJ01000006_gene2409	4.61e-80	259.0	28IUR@1|root,2Z8TE@2|Bacteria,1NW7C@1224|Proteobacteria,1RP4W@1236|Gammaproteobacteria,465G0@72275|Alteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_601492_1	469383.Cwoe_4146	1.56e-30	121.0	COG0624@1|root,COG0624@2|Bacteria,2GMH2@201174|Actinobacteria,4CQUX@84995|Rubrobacteria	84995|Rubrobacteria	E	Peptidase M20	-	-	3.4.17.11	ko:K01295	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
k59_1214234_1	1185652.USDA257_c56800	1.11e-95	290.0	COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,2TS83@28211|Alphaproteobacteria,4B70Z@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_825206_1	1380394.JADL01000009_gene3194	1.13e-89	276.0	COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,2TR8K@28211|Alphaproteobacteria,2JR9P@204441|Rhodospirillales	204441|Rhodospirillales	M	COG2230 Cyclopropane fatty acid synthase and related methyltransferases	-	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
k59_1716233_1	1238182.C882_4345	1.96e-47	169.0	COG0591@1|root,COG0591@2|Bacteria,1QUXM@1224|Proteobacteria,2TXK8@28211|Alphaproteobacteria,2JVHU@204441|Rhodospirillales	204441|Rhodospirillales	E	Sodium:solute symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
k59_267477_1	765698.Mesci_3862	1.64e-14	72.0	COG0861@1|root,COG0861@2|Bacteria,1PN8B@1224|Proteobacteria,2TUV5@28211|Alphaproteobacteria,43H27@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	PFAM Integral membrane protein TerC	terC	-	-	-	-	-	-	-	-	-	-	-	TerC
k59_267477_2	745014.OMB55_00020440	7.93e-08	55.5	COG2186@1|root,COG2186@2|Bacteria,1QZYM@1224|Proteobacteria,1T578@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Domain of unknown function (DUF5117)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4953,DUF5117
k59_1546373_1	671143.DAMO_2856	2.29e-93	302.0	COG0587@1|root,COG0587@2|Bacteria,2NNVY@2323|unclassified Bacteria	2|Bacteria	L	DNA polymerase	dnaE	GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032991,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0046483,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,RNase_T,tRNA_anti-codon
k59_716358_1	1123242.JH636435_gene1026	2.96e-08	59.3	COG2204@1|root,COG2204@2|Bacteria,2IYIG@203682|Planctomycetes	203682|Planctomycetes	T	CheY-like receiver AAA-type ATPase and DNA-binding domains	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_716361_1	1206743.BAGM01000095_gene2181	0.00025	46.2	COG1309@1|root,COG1309@2|Bacteria,2IM5N@201174|Actinobacteria,4G0PI@85025|Nocardiaceae	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_6,TetR_N
k59_1160904_1	999423.HMPREF9161_01611	9.81e-41	153.0	COG0326@1|root,COG0326@2|Bacteria,1TQEU@1239|Firmicutes,4H2HJ@909932|Negativicutes	909932|Negativicutes	O	Molecular chaperone. Has ATPase activity	htpG	-	-	ko:K04079	ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418	-	-	-	ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147	-	-	-	HATPase_c,HATPase_c_3,HSP90
k59_993558_1	243233.MCA0103	1.13e-74	243.0	COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,1RN9H@1236|Gammaproteobacteria,1XDPF@135618|Methylococcales	135618|Methylococcales	M	Catalyzes cross-linking of the peptidoglycan cell wall	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
k59_1273044_1	3880.AES92424	7.57e-05	46.2	2DSTA@1|root,2S6GN@2759|Eukaryota,37W7A@33090|Viridiplantae,3GK4J@35493|Streptophyta	35493|Streptophyta	S	Protein of unknown function (DUF2647)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2647
k59_825246_1	1238182.C882_4362	3.61e-50	164.0	COG0335@1|root,COG0335@2|Bacteria,1RH3A@1224|Proteobacteria,2U9DF@28211|Alphaproteobacteria,2JSS7@204441|Rhodospirillales	204441|Rhodospirillales	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	-	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
k59_825246_2	269796.Rru_A1189	2.06e-36	134.0	COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,2TR6K@28211|Alphaproteobacteria,2JQ8V@204441|Rhodospirillales	204441|Rhodospirillales	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
k59_1493807_1	95619.PM1_0211305	3.74e-56	198.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	methionine synthase	metH	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	iECO103_1326.ECO103_4764,iECUMN_1333.ECUMN_4545	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_1546419_1	379066.GAU_0737	5.47e-79	262.0	COG0587@1|root,COG0587@2|Bacteria,1ZT8N@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Helix-hairpin-helix motif	-	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP
k59_825269_1	349161.Dred_1181	0.000128	50.8	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,264GS@186807|Peptococcaceae	186801|Clostridia	NT	Methyl-accepting chemotaxis protein (MCP) signaling domain	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,dCache_1
k59_45988_1	204773.HEAR1546	1.94e-10	67.0	COG0672@1|root,COG2010@1|root,COG0672@2|Bacteria,COG2010@2|Bacteria,1MXHM@1224|Proteobacteria,2VIUK@28216|Betaproteobacteria,478DJ@75682|Oxalobacteraceae	28216|Betaproteobacteria	P	Iron permease FTR1 family	-	-	-	ko:K07243	-	-	-	-	ko00000,ko02000	2.A.108.1,2.A.108.2	-	-	Cytochrom_C,Cytochrome_CBB3,FTR1
k59_1049542_2	1089550.ATTH01000001_gene2180	1.52e-48	174.0	COG1196@1|root,COG1196@2|Bacteria,4NHWQ@976|Bacteroidetes,1FIP5@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
k59_267553_1	357808.RoseRS_0711	3.09e-27	103.0	COG0822@1|root,COG0822@2|Bacteria,2G71H@200795|Chloroflexi,37783@32061|Chloroflexia	32061|Chloroflexia	C	TIGRFAM SUF system FeS assembly protein, NifU family	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
k59_267553_2	1131266.ARWQ01000005_gene811	1.51e-56	188.0	COG0520@1|root,arCOG00065@2157|Archaea,41SCV@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	-	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
k59_1382337_1	1459636.NTE_03106	1.11e-60	196.0	COG0604@1|root,arCOG01458@2157|Archaea,41SZ9@651137|Thaumarchaeota	651137|Thaumarchaeota	C	PFAM Alcohol dehydrogenase GroES-like domain	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
k59_1382337_2	1459636.NTE_03105	9.77e-29	112.0	COG2301@1|root,arCOG00760@2157|Archaea,41S6F@651137|Thaumarchaeota	651137|Thaumarchaeota	G	HpcH/HpaI aldolase/citrate lyase family	-	-	4.1.3.34	ko:K01644	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
k59_1769413_1	420324.KI912060_gene5835	6.39e-34	125.0	COG2114@1|root,COG2114@2|Bacteria,1RG4J@1224|Proteobacteria,2U7PQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Adenylate cyclase	cyaJ	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc
k59_1273136_1	880070.Cycma_4788	3.38e-57	194.0	COG1228@1|root,COG1228@2|Bacteria,4NF27@976|Bacteroidetes,47JC0@768503|Cytophagia	976|Bacteroidetes	Q	PFAM amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,Amidohydro_3
k59_435916_1	1131813.AQVT01000001_gene2885	2.7e-80	246.0	COG1212@1|root,COG1212@2|Bacteria,1MUUU@1224|Proteobacteria,2TUQM@28211|Alphaproteobacteria,1JRV1@119045|Methylobacteriaceae	28211|Alphaproteobacteria	M	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria	kdsB	-	2.7.7.38	ko:K00979	ko00540,ko01100,map00540,map01100	M00063	R03351,R11396	RC00152,RC00910	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_3
k59_1214357_1	305900.GV64_07400	8.74e-118	368.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1XHXU@135619|Oceanospirillales	135619|Oceanospirillales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_46022_1	983545.Glaag_2146	5.66e-32	113.0	COG0236@1|root,COG0236@2|Bacteria,1MZ4P@1224|Proteobacteria,1S8X4@1236|Gammaproteobacteria,46B8P@72275|Alteromonadaceae	1236|Gammaproteobacteria	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0050896,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
k59_1657997_1	661478.OP10G_1178	1.53e-51	183.0	COG3420@1|root,COG3420@2|Bacteria	2|Bacteria	P	alginic acid biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,NosD
k59_494684_1	266117.Rxyl_0921	8.66e-46	159.0	COG1013@1|root,COG1013@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor	-	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016491,GO:0016625,GO:0016903,GO:0019752,GO:0033609,GO:0033611,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:1901575	1.2.7.1,1.2.7.10	ko:K00170,ko:K19071	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
k59_494684_2	985053.VMUT_1198	7.26e-13	68.9	COG0674@1|root,arCOG01608@2157|Archaea,2XQ5N@28889|Crenarchaeota	28889|Crenarchaeota	C	Pyruvate:ferredoxin oxidoreductase core domain II	-	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
k59_1436949_1	649638.Trad_0516	2.17e-07	53.5	COG3629@1|root,COG3629@2|Bacteria,1WKHY@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	PFAM Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,TPR_8
k59_716528_1	1469245.JFBG01000036_gene1966	1.67e-57	189.0	COG3180@1|root,COG3180@2|Bacteria,1MUFS@1224|Proteobacteria,1RPMJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Ammonia monooxygenase	abrB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K07120	-	-	-	-	ko00000	-	-	-	AbrB
k59_1104013_1	671143.DAMO_2491	1e-107	318.0	COG1028@1|root,COG1028@2|Bacteria,2NQBD@2323|unclassified Bacteria	2|Bacteria	IQ	NAD(P)H binding domain of trans-2-enoyl-CoA reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_211495_1	944479.JQLX01000016_gene324	9.15e-22	101.0	COG2199@1|root,COG2199@2|Bacteria,1MUV8@1224|Proteobacteria,4342D@68525|delta/epsilon subdivisions,2X4TR@28221|Deltaproteobacteria,2M6TF@213113|Desulfurellales	28221|Deltaproteobacteria	T	Cache domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS_9,dCache_2
k59_158048_1	1502850.FG91_00796	3.56e-08	60.8	COG0823@1|root,COG1228@1|root,COG0823@2|Bacteria,COG1228@2|Bacteria,1R5P1@1224|Proteobacteria,2U0ZV@28211|Alphaproteobacteria,2KEB5@204457|Sphingomonadales	204457|Sphingomonadales	QU	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,PD40
k59_1437001_1	204669.Acid345_2974	9.03e-62	203.0	COG0573@1|root,COG0573@2|Bacteria,3Y42Y@57723|Acidobacteria,2JIJN@204432|Acidobacteriia	204432|Acidobacteriia	P	probably responsible for the translocation of the substrate across the membrane	-	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
k59_1104038_1	1120956.JHZK01000017_gene2626	1.18e-94	291.0	COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,2TRI7@28211|Alphaproteobacteria,1JN91@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Circularly permuted ATP-grasp type 2	MA20_32420	-	-	-	-	-	-	-	-	-	-	-	CP_ATPgrasp_2
k59_603041_3	1178540.BA70_08125	5.59e-05	45.4	COG2259@1|root,COG2259@2|Bacteria,1VCS2@1239|Firmicutes,4HKRK@91061|Bacilli,1ZHVA@1386|Bacillus	91061|Bacilli	S	DoxX	-	-	-	-	-	-	-	-	-	-	-	-	DoxX
k59_1605727_1	388413.ALPR1_05670	3.13e-100	309.0	COG3653@1|root,COG3653@2|Bacteria,4NHDD@976|Bacteroidetes,47KC3@768503|Cytophagia	976|Bacteroidetes	Q	PFAM D-aminoacylase, C-terminal region	-	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
k59_603042_2	1177154.Y5S_02568	4.35e-37	131.0	COG2135@1|root,COG2135@2|Bacteria,1RCCC@1224|Proteobacteria,1S39B@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Belongs to the SOS response-associated peptidase family	-	-	-	-	-	-	-	-	-	-	-	-	SRAP
k59_159922_1	671143.DAMO_2288	7.46e-93	279.0	COG1414@1|root,COG1414@2|Bacteria,2NR17@2323|unclassified Bacteria	2|Bacteria	K	helix_turn_helix isocitrate lyase regulation	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
k59_1771163_1	926569.ANT_12110	1.93e-64	213.0	COG0739@1|root,COG1388@1|root,COG0739@2|Bacteria,COG1388@2|Bacteria	2|Bacteria	M	LysM domain	-	-	2.7.7.6	ko:K03046,ko:K03641,ko:K08642	ko00230,ko00240,ko01100,ko02024,ko03020,map00230,map00240,map01100,map02024,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko01002,ko02000,ko03021,ko03400	2.C.1.2	-	-	Glyco_hydro_18,LysM,OapA,PD40,Peptidase_M23
k59_1275534_1	1163617.SCD_n01727	3.09e-29	116.0	COG1053@1|root,COG1053@2|Bacteria,1NZBR@1224|Proteobacteria,2VHJ5@28216|Betaproteobacteria	28216|Betaproteobacteria	C	PFAM fumarate reductase succinate dehydrogenase flavoprotein domain protein	-	-	1.8.99.2	ko:K00394	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00596	R00860,R04927,R08553	RC00007,RC01239,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_1275534_2	1049564.TevJSym_aa01860	4.94e-10	58.9	COG1051@1|root,COG1051@2|Bacteria,1QTT4@1224|Proteobacteria,1RQ35@1236|Gammaproteobacteria,1J69Z@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	COG1051 ADP-ribose pyrophosphatase	nuhA	-	-	-	-	-	-	-	-	-	-	-	NUDIX
k59_1659788_1	1499967.BAYZ01000095_gene4241	3.84e-80	270.0	COG2304@1|root,COG2304@2|Bacteria	2|Bacteria	IU	oxidoreductase activity	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	GATase1_like,VWA,VWA_2,VWA_3
k59_1105964_1	639030.JHVA01000001_gene2646	3.26e-14	73.9	COG0577@1|root,COG0577@2|Bacteria,3Y34I@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_1105964_2	518766.Rmar_1154	4.03e-24	101.0	COG2303@1|root,COG2303@2|Bacteria,4NMEP@976|Bacteroidetes,1FJS3@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	E	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO,GMC_oxred_C
k59_159933_1	991905.SL003B_4075	3.02e-48	168.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria	1224|Proteobacteria	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_38,HTH_7,rve
k59_47870_1	986075.CathTA2_2530	4.72e-75	233.0	COG0090@1|root,COG0090@2|Bacteria,1TP9X@1239|Firmicutes,4HAE8@91061|Bacilli	91061|Bacilli	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
k59_883297_1	1121090.KB894696_gene108	1.3e-22	101.0	COG0471@1|root,COG0471@2|Bacteria,1UI5K@1239|Firmicutes,4HC1Q@91061|Bacilli,1ZEGQ@1386|Bacillus	91061|Bacilli	P	Sodium:sulfate symporter transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,Na_sulph_symp,TrkA_C
k59_1659821_1	1307759.JOMJ01000004_gene2910	2.83e-10	63.5	COG1579@1|root,COG1579@2|Bacteria,1R7GT@1224|Proteobacteria,42P3S@68525|delta/epsilon subdivisions,2WKVG@28221|Deltaproteobacteria,2M888@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	C4-type zinc ribbon domain	-	-	-	ko:K07164	-	-	-	-	ko00000	-	-	-	zf-RING_7
k59_883305_1	1445613.JALM01000001_gene3184	3.75e-12	71.2	COG0028@1|root,COG0028@2|Bacteria,2GKGX@201174|Actinobacteria,4DZZ5@85010|Pseudonocardiales	201174|Actinobacteria	EH	Belongs to the TPP enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_1162946_2	1502850.FG91_00780	9.61e-19	82.4	COG1917@1|root,COG1917@2|Bacteria,1QVVQ@1224|Proteobacteria,2TVET@28211|Alphaproteobacteria,2K5FZ@204457|Sphingomonadales	204457|Sphingomonadales	S	Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate	nbaC	-	1.13.11.6	ko:K00452	ko00380,ko01100,map00380,map01100	M00038	R02665	RC00387	ko00000,ko00001,ko00002,ko01000	-	-	-	3-HAO
k59_269049_1	1128421.JAGA01000002_gene1306	1.73e-60	191.0	COG2050@1|root,COG2050@2|Bacteria	2|Bacteria	Q	thiolester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
k59_995253_1	378806.STAUR_6894	4.1e-54	182.0	COG1878@1|root,COG1878@2|Bacteria,1MVWU@1224|Proteobacteria	1224|Proteobacteria	S	Metal-dependent hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
k59_159975_3	338966.Ppro_0858	3.35e-13	66.2	COG0599@1|root,COG0599@2|Bacteria	2|Bacteria	S	peroxiredoxin activity	-	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD
k59_1605800_1	714943.Mucpa_2476	1.1e-72	245.0	COG3533@1|root,COG3533@2|Bacteria,4NF8W@976|Bacteroidetes,1IP7E@117747|Sphingobacteriia	976|Bacteroidetes	S	COGs COG3533 conserved	-	-	-	ko:K09955	-	-	-	-	ko00000	-	-	-	DUF4986,Glyco_hydro_127
k59_1162971_1	1432055.GLUCORHAEAF1_00795	6.49e-15	79.3	COG1001@1|root,COG1001@2|Bacteria,1MVFP@1224|Proteobacteria,2TR1X@28211|Alphaproteobacteria,2JRAF@204441|Rhodospirillales	204441|Rhodospirillales	F	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family	-	-	3.5.4.2	ko:K01486	ko00230,ko01100,map00230,map01100	-	R01244	RC00477	ko00000,ko00001,ko01000	-	-	-	Adenine_deam_C,Amidohydro_1
k59_212805_1	1403819.BATR01000183_gene6312	9.99e-10	64.7	COG0845@1|root,COG0845@2|Bacteria,46UGE@74201|Verrucomicrobia,2IVKB@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	Biotin-lipoyl like	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_D23
k59_1275624_1	517418.Ctha_1737	1.79e-35	138.0	COG1629@1|root,COG4771@2|Bacteria,1FEFM@1090|Chlorobi	1090|Chlorobi	P	CarboxypepD_reg-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
k59_952415_58	1536597.A0A088F6J4_9CAUD	2.68e-144	421.0	4QAIK@10239|Viruses,4QPEB@28883|Caudovirales,4QP3P@10744|Podoviridae	10744|Podoviridae	S	phosphoprotein phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_952415_61	1177928.TH2_20096	1.12e-34	125.0	COG0741@1|root,COG0741@2|Bacteria,1N0U8@1224|Proteobacteria,2UICK@28211|Alphaproteobacteria,2JTZJ@204441|Rhodospirillales	204441|Rhodospirillales	M	lytic transglycosylase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1008303_1	706587.Desti_1505	1.4e-22	100.0	COG0477@1|root,COG2814@2|Bacteria,1MUZ8@1224|Proteobacteria,42YIF@68525|delta/epsilon subdivisions,2WU4S@28221|Deltaproteobacteria,2MQET@213462|Syntrophobacterales	28221|Deltaproteobacteria	EGP	PFAM Major Facilitator Superfamily	-	-	-	ko:K08218	ko01501,map01501	M00628	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.25	-	-	MFS_1
k59_1564037_3	344747.PM8797T_27949	3.64e-45	150.0	COG3436@1|root,COG3436@2|Bacteria	2|Bacteria	L	PFAM IS66 Orf2 family protein	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	TnpB_IS66
k59_1564037_4	234267.Acid_2941	7.43e-137	395.0	2DB88@1|root,2Z7QT@2|Bacteria,3Y61J@57723|Acidobacteria	2|Bacteria	S	Domain of unknown function (DUF4338)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4338
k59_1231342_1	861299.J421_4001	2.38e-39	144.0	COG3616@1|root,COG3616@2|Bacteria,1ZSM9@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Putative serine dehydratase domain	-	-	-	-	-	-	-	-	-	-	-	-	Ala_racemase_N,D-ser_dehydrat
k59_730451_1	1499967.BAYZ01000019_gene6271	1.62e-61	198.0	COG2120@1|root,COG2120@2|Bacteria	2|Bacteria	S	N-acetylglucosaminylinositol deacetylase activity	-	-	-	ko:K01463	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
k59_1675270_1	886293.Sinac_0821	1.11e-69	229.0	COG0589@1|root,COG1914@1|root,COG0589@2|Bacteria,COG1914@2|Bacteria,2J0SG@203682|Planctomycetes	203682|Planctomycetes	P	Natural resistance-associated macrophage protein	mntH	-	-	ko:K03322	-	-	-	-	ko00000,ko02000	2.A.55.2.6,2.A.55.3	-	-	Nramp
k59_507822_2	1382356.JQMP01000001_gene1157	1.83e-37	139.0	COG1060@1|root,COG1060@2|Bacteria,2GBD4@200795|Chloroflexi,27YV4@189775|Thermomicrobia	189775|Thermomicrobia	H	Elongator protein 3, MiaB family, Radical SAM	-	-	2.5.1.77	ko:K11779	ko00680,ko01120,map00680,map01120	M00378	R09396	RC01381,RC03002,RC03007	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
k59_1730779_2	219305.MCAG_01386	2.85e-38	142.0	COG5276@1|root,COG5276@2|Bacteria,2IAAZ@201174|Actinobacteria,4DBJS@85008|Micromonosporales	201174|Actinobacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD,P_proprotein
k59_1675274_1	1382306.JNIM01000001_gene2993	3.67e-85	260.0	COG0667@1|root,COG0667@2|Bacteria,2G5VT@200795|Chloroflexi	200795|Chloroflexi	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_7681_1	1101195.Meth11DRAFT_2494	1.58e-30	123.0	COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,2VI5J@28216|Betaproteobacteria,2KMI1@206350|Nitrosomonadales	206350|Nitrosomonadales	M	PFAM AsmA family	-	-	-	ko:K07289	-	-	-	-	ko00000	-	-	-	AsmA,AsmA_2
k59_7681_2	1159870.KB907784_gene670	2.37e-23	98.6	COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,2VM4Z@28216|Betaproteobacteria,3T8WW@506|Alcaligenaceae	28216|Betaproteobacteria	S	Metal-dependent amidase aminoacylase carboxypeptidase	yxeP_2	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
k59_1341699_1	1367847.JCM7686_1543	1.29e-45	155.0	COG0307@1|root,COG0307@2|Bacteria,1MUMB@1224|Proteobacteria,2U3RS@28211|Alphaproteobacteria,2PU1T@265|Paracoccus	28211|Alphaproteobacteria	H	Lumazine binding domain	ribE	GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
k59_63041_2	272943.RSP_2235	1.31e-05	48.1	COG1680@1|root,COG1680@2|Bacteria,1NHIY@1224|Proteobacteria,2U0A3@28211|Alphaproteobacteria,1FD4P@1060|Rhodobacter	28211|Alphaproteobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_396578_1	861299.J421_5846	8.37e-10	65.5	COG0457@1|root,COG3629@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	AAA_16,BTAD,TPR_12,Trans_reg_C
k59_63042_1	926569.ANT_25160	1.24e-87	273.0	COG0612@1|root,COG0612@2|Bacteria,2G68H@200795|Chloroflexi	200795|Chloroflexi	S	Insulinase (Peptidase family M16)	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_785817_1	1545915.JROG01000009_gene2803	6.1e-76	253.0	COG4447@1|root,COG4447@2|Bacteria,1MVIT@1224|Proteobacteria,2VEV5@28211|Alphaproteobacteria,2K7TR@204457|Sphingomonadales	204457|Sphingomonadales	S	K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
k59_1730803_1	1235792.C808_04909	1.67e-84	251.0	COG1943@1|root,COG1943@2|Bacteria,1TSQ0@1239|Firmicutes,25CMS@186801|Clostridia,27U60@186928|unclassified Lachnospiraceae	186801|Clostridia	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
k59_730493_1	1124780.ANNU01000006_gene2919	4.49e-81	258.0	COG1066@1|root,COG1066@2|Bacteria,4NEYA@976|Bacteroidetes,47K0I@768503|Cytophagia	976|Bacteroidetes	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI
k59_897258_1	1122138.AQUZ01000019_gene8174	7.42e-76	253.0	COG0737@1|root,COG1524@1|root,COG3379@1|root,COG0737@2|Bacteria,COG1524@2|Bacteria,COG3379@2|Bacteria,2HFJ5@201174|Actinobacteria,4DVDK@85009|Propionibacteriales	201174|Actinobacteria	F	5'-nucleotidase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	5_nucleotid_C
k59_1675331_1	926569.ANT_04140	6.42e-87	278.0	COG0542@1|root,COG0542@2|Bacteria,2G62D@200795|Chloroflexi	200795|Chloroflexi	O	ATPase associated with various cellular activities, AAA_5	-	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_340853_1	1502851.FG93_02159	1.52e-30	119.0	COG3221@1|root,COG3221@2|Bacteria,1MWFF@1224|Proteobacteria,2TUB4@28211|Alphaproteobacteria,3JYQH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	ABC transporter, phosphonate, periplasmic substrate-binding protein	phnD	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	Phosphonate-bd
k59_1231429_1	1305737.JAFX01000001_gene1824	1.31e-30	126.0	COG1629@1|root,COG4771@2|Bacteria,4NDU8@976|Bacteroidetes,47M35@768503|Cytophagia	976|Bacteroidetes	P	PFAM TonB-dependent Receptor Plug	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
k59_118455_1	1122222.AXWR01000009_gene751	7.41e-36	132.0	COG0232@1|root,COG0232@2|Bacteria,1WI39@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	F	Belongs to the dGTPase family. Type 2 subfamily	-	GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016787,GO:0016788,GO:0016793,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
k59_1675342_1	1117647.M5M_19115	6.16e-21	87.4	COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,1S8RS@1236|Gammaproteobacteria,1J6H1@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	U	Biopolymer transport protein	tolR	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0015833,GO:0015893,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032153,GO:0042221,GO:0042493,GO:0042886,GO:0042891,GO:0043213,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	ExbD
k59_507898_1	546271.Selsp_1049	4.54e-08	58.9	COG0136@1|root,COG0136@2|Bacteria,1TPC6@1239|Firmicutes,4H2D9@909932|Negativicutes	909932|Negativicutes	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
k59_1397374_1	861299.J421_6243	9.43e-11	68.2	COG4888@1|root,COG4888@2|Bacteria,1ZURG@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
k59_1174954_1	493475.GARC_2946	1.54e-45	163.0	COG0845@1|root,COG0845@2|Bacteria,1MVAS@1224|Proteobacteria,1RPBZ@1236|Gammaproteobacteria,464X2@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	cusB	-	-	ko:K07798	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4,8.A.1	-	-	CusF_Ec,HlyD_D23,HlyD_D4
k59_285617_1	1168034.FH5T_01630	1.47e-80	247.0	COG0437@1|root,COG0437@2|Bacteria,4NIEP@976|Bacteroidetes	976|Bacteroidetes	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_11,Fer4_4
k59_174258_1	1502851.FG93_04329	4.86e-27	105.0	COG1268@1|root,COG1268@2|Bacteria,1RH78@1224|Proteobacteria,2U9DN@28211|Alphaproteobacteria,3JRUX@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	BioY family	-	-	-	ko:K03523	ko02010,map02010	M00581,M00582	-	-	ko00000,ko00001,ko00002,ko02000	2.A.88.1,2.A.88.2	-	-	BioY
k59_396652_1	399795.CtesDRAFT_PD3411	2.59e-20	89.4	COG3193@1|root,COG3193@2|Bacteria,1REF5@1224|Proteobacteria,2VT55@28216|Betaproteobacteria,4AEYR@80864|Comamonadaceae	28216|Betaproteobacteria	S	Haem-degrading	-	-	-	-	-	-	-	-	-	-	-	-	Haem_degrading
k59_1397388_1	388413.ALPR1_03880	1.01e-33	133.0	COG2207@1|root,COG3063@1|root,COG5616@1|root,COG2207@2|Bacteria,COG3063@2|Bacteria,COG5616@2|Bacteria,4NFW7@976|Bacteroidetes,47RPJ@768503|Cytophagia	976|Bacteroidetes	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,TPR_8
k59_1008417_1	1121930.AQXG01000002_gene2392	2.19e-31	123.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Cu_amine_oxidN1,Phytase-like
k59_452523_1	485916.Dtox_2850	9.59e-11	67.8	COG5434@1|root,COG5434@2|Bacteria,1UJS5@1239|Firmicutes,24DNN@186801|Clostridia,26469@186807|Peptococcaceae	186801|Clostridia	M	Right handed beta helix region	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
k59_1619562_1	1007103.AFHW01000104_gene5152	1.87e-27	106.0	COG0781@1|root,COG0781@2|Bacteria,1VA9B@1239|Firmicutes,4HKMU@91061|Bacilli,26RGJ@186822|Paenibacillaceae	91061|Bacilli	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
k59_507933_1	518766.Rmar_0264	4.86e-51	169.0	COG5000@1|root,COG5000@2|Bacteria	2|Bacteria	T	phosphorelay sensor kinase activity	-	-	2.7.13.1	ko:K03406,ko:K05962	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	4HB_MCP_1,DUF3365,HAMP,HATPase_c,HisKA,MCPsignal,PAS,dCache_1
k59_618946_1	318996.AXAZ01000051_gene3938	3.16e-73	239.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,3JR8W@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc
k59_1508624_1	622637.KE124774_gene4122	4.87e-80	246.0	COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,2TRYS@28211|Alphaproteobacteria,36XEH@31993|Methylocystaceae	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase/isomerase	paaF	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
k59_118503_1	396588.Tgr7_1182	4.51e-44	157.0	COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,1RM92@1236|Gammaproteobacteria,1WWJ8@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
k59_118503_2	762982.HMPREF9442_00584	1.45e-06	49.3	COG0148@1|root,COG0148@2|Bacteria,4NF5M@976|Bacteroidetes,2FMNI@200643|Bacteroidia	976|Bacteroidetes	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
k59_952565_1	387631.Asulf_00452	9.41e-21	85.1	COG0826@1|root,arCOG03202@2157|Archaea	2157|Archaea	O	PFAM peptidase U32	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_U32
k59_507945_1	744980.TRICHSKD4_0236	2.94e-14	77.4	COG3385@1|root,COG3385@2|Bacteria,1QURV@1224|Proteobacteria,2TW56@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG2183 Transcriptional accessory protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k59_507947_1	292459.STH2612	7.46e-28	116.0	COG0642@1|root,COG2205@2|Bacteria,1TRAB@1239|Firmicutes,24DV3@186801|Clostridia	186801|Clostridia	T	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	DUF4173
k59_174312_1	926569.ANT_12050	1.47e-67	212.0	COG3634@1|root,COG3634@2|Bacteria,2G6SQ@200795|Chloroflexi	200795|Chloroflexi	O	TIGRFAM glutaredoxin-like domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_3
k59_952575_1	266835.14021729	2.6e-104	318.0	COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,2TQPS@28211|Alphaproteobacteria,43IJJ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042,ko:K11528	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transf_3
k59_1231516_1	31964.pCSL0064	8.82e-102	307.0	COG2801@1|root,COG2801@2|Bacteria,2GJ3V@201174|Actinobacteria,4FKT9@85023|Microbacteriaceae	201174|Actinobacteria	L	insertion element IS1121 transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,LZ_Tnp_IS481,rve,rve_3
k59_899425_1	1038866.KB902825_gene1151	7.55e-61	199.0	COG0582@1|root,COG0582@2|Bacteria,1NX90@1224|Proteobacteria,2TV8K@28211|Alphaproteobacteria,3JRYH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
k59_1121814_1	1416752.AYME01000008_gene3371	9.12e-10	57.4	COG0789@1|root,COG0789@2|Bacteria,2IMEG@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MerR,MerR-DNA-bind,MerR_1
k59_1288099_1	379066.GAU_0751	4.47e-82	254.0	COG0320@1|root,COG0320@2|Bacteria,1ZTA3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
k59_899429_1	1320556.AVBP01000001_gene4641	2.8e-11	63.2	COG5368@1|root,COG5368@2|Bacteria,1NX2K@1224|Proteobacteria,2U1B2@28211|Alphaproteobacteria,43RF4@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Putative glucoamylase	-	-	-	-	-	-	-	-	-	-	-	-	Glycoamylase
k59_899429_2	935863.AWZR01000003_gene2775	8.09e-159	464.0	COG5368@1|root,COG5368@2|Bacteria,1NX2K@1224|Proteobacteria,1RY8M@1236|Gammaproteobacteria,1X3JA@135614|Xanthomonadales	135614|Xanthomonadales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Glycoamylase
k59_1065745_1	1121935.AQXX01000132_gene2652	2.55e-05	47.0	COG1680@1|root,COG1680@2|Bacteria,1QD0J@1224|Proteobacteria,1RR1C@1236|Gammaproteobacteria,1XP2A@135619|Oceanospirillales	135619|Oceanospirillales	V	Beta-lactamase class C and other penicillin binding	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_21188_1	983917.RGE_13030	3.31e-18	80.5	COG0454@1|root,COG0454@2|Bacteria,1QUHE@1224|Proteobacteria,2VTMP@28216|Betaproteobacteria,1KNRR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	ko:K03829	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1
k59_21188_2	1177154.Y5S_02703	1.85e-12	67.0	COG1024@1|root,COG1024@2|Bacteria,1NDT7@1224|Proteobacteria,1RSCI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
k59_688779_1	1298880.AUEV01000016_gene2252	2.22e-55	195.0	COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,2GJ11@201174|Actinobacteria	201174|Actinobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvP	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	1.4.4.2	ko:K00281,ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
k59_1411019_1	570417.WP0972	2.31e-39	143.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,2U1Z0@28211|Alphaproteobacteria,47GRS@766|Rickettsiales	766|Rickettsiales	L	Group II intron, maturase-specific domain	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k59_187470_1	497965.Cyan7822_3673	6.55e-87	268.0	COG1104@1|root,COG1104@2|Bacteria,1G0D5@1117|Cyanobacteria,3KG9T@43988|Cyanothece	1117|Cyanobacteria	H	Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine	nifS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
k59_1411027_1	1448860.BBJO01000055_gene82	2.27e-43	157.0	COG1012@1|root,arCOG01252@2157|Archaea,2XVV5@28890|Euryarchaeota,23U7E@183963|Halobacteria	183963|Halobacteria	C	Aldehyde dehydrogenase family	-	-	1.2.1.88	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	-	R00245,R00707,R00708,R04444,R04445,R05051	RC00080,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000	-	-	-	Aldedh
k59_243384_1	751994.AGIG01000007_gene1306	1.28e-31	122.0	COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,1RMFQ@1236|Gammaproteobacteria,1J4R8@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006996,GO:0007059,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0022607,GO:0022611,GO:0022613,GO:0022618,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0042254,GO:0042255,GO:0043021,GO:0043023,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044087,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0065003,GO:0065007,GO:0070925,GO:0071826,GO:0071840,GO:0090069,GO:0090071,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GTP1_OBG,MMR_HSR1
k59_299105_1	485913.Krac_11000	7.89e-10	59.7	COG1609@1|root,COG1609@2|Bacteria	2|Bacteria	K	purine nucleotide biosynthetic process	-	-	5.3.1.12	ko:K01812,ko:K02529,ko:K16210	ko00040,ko01100,map00040,map01100	M00061,M00631	R01482,R01983	RC00376	ko00000,ko00001,ko00002,ko01000,ko02000,ko03000	2.A.2.5	-	-	DDE_Tnp_ISAZ013,Peripla_BP_3
k59_299105_2	485913.Krac_11000	1.2e-84	264.0	COG1609@1|root,COG1609@2|Bacteria	2|Bacteria	K	purine nucleotide biosynthetic process	-	-	5.3.1.12	ko:K01812,ko:K02529,ko:K16210	ko00040,ko01100,map00040,map01100	M00061,M00631	R01482,R01983	RC00376	ko00000,ko00001,ko00002,ko01000,ko02000,ko03000	2.A.2.5	-	-	DDE_Tnp_ISAZ013,Peripla_BP_3
k59_688804_1	706587.Desti_0562	9.13e-24	104.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WIWE@28221|Deltaproteobacteria,2MQU0@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	PDZ domain (Also known as DHR or GLGF)	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
k59_410305_1	5808.XP_002139339.1	1.98e-07	57.8	COG2114@1|root,KOG4171@2759|Eukaryota	2759|Eukaryota	T	guanylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc
k59_1299756_1	443143.GM18_3150	1.27e-62	196.0	2AZF8@1|root,31RP4@2|Bacteria,1RIZG@1224|Proteobacteria,42ZVQ@68525|delta/epsilon subdivisions,2WV5D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1577700_1	1305735.JAFT01000005_gene1232	1.3e-42	157.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TSB1@28211|Alphaproteobacteria,2PDR0@252301|Oceanicola	28211|Alphaproteobacteria	EH	Belongs to the TPP enzyme family	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_354042_1	1121935.AQXX01000131_gene2850	3.52e-110	328.0	COG0807@1|root,COG0807@2|Bacteria,1PCQR@1224|Proteobacteria,1SJVN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	GTP cyclohydrolase N terminal	-	-	-	-	-	-	-	-	-	-	-	-	GTP_CH_N,GTP_cyclohydro2
k59_576567_1	644966.Tmar_0683	8.11e-10	61.6	COG2021@1|root,COG2021@2|Bacteria,1UMHR@1239|Firmicutes,25GIJ@186801|Clostridia,3WDQ0@538999|Clostridiales incertae sedis	186801|Clostridia	E	TIGRFAM proline-specific peptidases, Bacillus coagulans-type subfamily	-	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1
k59_1689017_1	1121904.ARBP01000038_gene2558	2.1e-23	100.0	COG0726@1|root,COG0726@2|Bacteria,4PMVX@976|Bacteroidetes,47NMS@768503|Cytophagia	976|Bacteroidetes	G	Cellulase N-terminal ig-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CelD_N,Glyco_hydro_9
k59_354071_1	290512.Paes_2335	1.18e-51	183.0	COG0706@1|root,COG0706@2|Bacteria,1FDGH@1090|Chlorobi	1090|Chlorobi	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
k59_1466762_1	479434.Sthe_1092	1.48e-74	249.0	COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,2G86T@200795|Chloroflexi,27XQK@189775|Thermomicrobia	189775|Thermomicrobia	G	Alpha-amylase domain	-	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	APH,Alpha-amylase,Malt_amylase_C
k59_521626_1	396513.SCA_0432	6.53e-73	245.0	COG0557@1|root,COG0557@2|Bacteria,1TQ1G@1239|Firmicutes,4HBBH@91061|Bacilli,4GY4Y@90964|Staphylococcaceae	91061|Bacilli	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
k59_1411105_1	383372.Rcas_2335	4.88e-29	113.0	COG0240@1|root,COG0240@2|Bacteria,2G6HJ@200795|Chloroflexi,376MV@32061|Chloroflexia	32061|Chloroflexia	C	NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain	-	-	1.5.1.28	ko:K04940	-	-	-	-	ko00000,ko01000	-	-	-	NAD_Gly3P_dh_N,Octopine_DH
k59_1411105_2	926569.ANT_01060	1.14e-26	109.0	COG5012@1|root,COG5012@2|Bacteria,2G66F@200795|Chloroflexi	200795|Chloroflexi	D	cobalamin binding	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding
k59_354081_1	1415756.JQMY01000001_gene774	6.11e-33	129.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2TSSI@28211|Alphaproteobacteria,2PCGW@252301|Oceanicola	28211|Alphaproteobacteria	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
k59_1246027_1	118173.KB235914_gene646	8.73e-97	293.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5,DDE_Tnp_1
k59_76584_1	1283299.AUKG01000001_gene1281	3.01e-58	204.0	COG0508@1|root,COG0567@1|root,COG0508@2|Bacteria,COG0567@2|Bacteria,2GIU6@201174|Actinobacteria,4CPG1@84995|Rubrobacteria	84995|Rubrobacteria	C	2-oxoglutarate dehydrogenase C-terminal	-	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,2-oxogl_dehyd_N,Biotin_lipoyl,E1_dh,E3_binding,OxoGdeHyase_C,Transket_pyr
k59_576621_2	296591.Bpro_3023	5.6e-13	67.4	COG1024@1|root,COG1024@2|Bacteria,1MXBB@1224|Proteobacteria,2VICM@28216|Betaproteobacteria,4AD3D@80864|Comamonadaceae	28216|Betaproteobacteria	I	Enoyl-CoA hydratase carnithine racemase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
k59_1577760_1	745718.JADT01000001_gene1543	7.96e-08	59.3	COG2304@1|root,COG2931@1|root,COG3209@1|root,COG2304@2|Bacteria,COG2931@2|Bacteria,COG3209@2|Bacteria,4PKBQ@976|Bacteroidetes,1IJ7S@117743|Flavobacteriia	976|Bacteroidetes	M	SPTR CHU large protein	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,Calx-beta,DUF11,HYR,SprB
k59_1133683_1	926550.CLDAP_13210	8.59e-44	157.0	COG1207@1|root,COG1207@2|Bacteria,2G5VC@200795|Chloroflexi	200795|Chloroflexi	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transf_3
k59_1299850_1	1114972.AUAW01000016_gene896	2.79e-45	156.0	COG0053@1|root,COG0053@2|Bacteria,1V9B6@1239|Firmicutes,4HJTJ@91061|Bacilli,3F4M1@33958|Lactobacillaceae	91061|Bacilli	P	Cation efflux family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux
k59_744138_1	1120956.JHZK01000010_gene2791	6.36e-84	254.0	COG5012@1|root,COG5012@2|Bacteria,1RDEU@1224|Proteobacteria,2TVXN@28211|Alphaproteobacteria,1JNIM@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	B12 binding domain	mtbC	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2
k59_1522051_1	1121405.dsmv_1099	1.39e-86	264.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,42N06@68525|delta/epsilon subdivisions,2WK5N@28221|Deltaproteobacteria,2MMZ0@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Transketolase, pyrimidine binding domain	bkdB	-	1.2.4.1,1.2.4.4	ko:K00162,ko:K00167	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
k59_854092_1	760568.Desku_2099	9.17e-20	90.1	COG1216@1|root,COG1216@2|Bacteria,1VE3R@1239|Firmicutes	1239|Firmicutes	S	Glycosyl Transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_1188618_1	1121115.AXVN01000007_gene3515	2.8e-20	87.8	COG0454@1|root,COG0456@2|Bacteria,1V6CE@1239|Firmicutes,24K86@186801|Clostridia,3Y1JJ@572511|Blautia	186801|Clostridia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_131838_1	1144275.COCOR_02334	2.01e-62	208.0	COG2303@1|root,COG2303@2|Bacteria,1NV3A@1224|Proteobacteria,42NVR@68525|delta/epsilon subdivisions,2WM9A@28221|Deltaproteobacteria,2YU0T@29|Myxococcales	28221|Deltaproteobacteria	E	GMC oxidoreductase	-	-	1.1.3.6	ko:K03333	ko00984,ko01120,map00984,map01120	-	R01459	RC00146	ko00000,ko00001,ko01000	-	-	-	FAD_binding_2,GMC_oxred_C,GMC_oxred_N,NAD_binding_8
k59_299214_1	926569.ANT_03590	5.28e-62	214.0	COG0744@1|root,COG0744@2|Bacteria,2G5ZG@200795|Chloroflexi	200795|Chloroflexi	M	PFAM glycosyl transferase, family 51	-	-	-	-	-	-	-	-	-	-	-	-	Transgly,Transpeptidase
k59_521665_1	994479.GL877878_gene3102	1.37e-25	105.0	COG2086@1|root,COG2086@2|Bacteria,2GKV6@201174|Actinobacteria,4E0JQ@85010|Pseudonocardiales	201174|Actinobacteria	C	Electron transfer flavoprotein	etfB	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016020,GO:0016491,GO:0022900,GO:0030312,GO:0040007,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
k59_688911_1	1267535.KB906767_gene3530	3.34e-18	89.0	COG0577@1|root,COG0577@2|Bacteria,3Y3U3@57723|Acidobacteria,2JMJ0@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_576649_2	391037.Sare_0183	1.62e-54	183.0	COG1266@1|root,COG1266@2|Bacteria,2IGUR@201174|Actinobacteria,4DK0K@85008|Micromonosporales	201174|Actinobacteria	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
k59_1466816_2	1121875.KB907552_gene310	3.68e-44	153.0	COG0289@1|root,COG0289@2|Bacteria,4NEAS@976|Bacteroidetes,1I00U@117743|Flavobacteriia	976|Bacteroidetes	E	Belongs to the DapB family	-	-	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
k59_799718_1	387092.NIS_0181	4.35e-52	179.0	COG1215@1|root,COG1215@2|Bacteria,1MXG7@1224|Proteobacteria,42Q7W@68525|delta/epsilon subdivisions,2YQ1A@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	M	Glycosyl transferase family 21	-	-	-	ko:K11936	ko02026,map02026	-	-	-	ko00000,ko00001,ko01000,ko01003,ko02000	4.D.1.1.2,4.D.1.1.3	GT2	-	Glyco_tranf_2_3
k59_1355708_1	926569.ANT_04650	8.23e-133	389.0	COG0031@1|root,COG0031@2|Bacteria,2G8GE@200795|Chloroflexi	200795|Chloroflexi	E	Pyridoxal-phosphate dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	PALP
k59_1522087_1	309801.trd_A0913	8.35e-29	109.0	COG4911@1|root,COG4911@2|Bacteria,2G7A8@200795|Chloroflexi,27YIV@189775|Thermomicrobia	189775|Thermomicrobia	S	Uncharacterized conserved protein (DUF2203)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2203
k59_631898_1	743299.Acife_1720	1.82e-27	110.0	COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,1RMFM@1236|Gammaproteobacteria,2NDMV@225057|Acidithiobacillales	225057|Acidithiobacillales	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
k59_631898_2	330214.NIDE4326	4.7e-47	157.0	2CK1C@1|root,32SJA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_131864_1	1380384.JADN01000010_gene6	1.57e-13	72.0	COG2326@1|root,COG2326@2|Bacteria,4NFJ5@976|Bacteroidetes,1HWS5@117743|Flavobacteriia	976|Bacteroidetes	S	nucleotide phosphotransferase	-	-	2.7.4.1	ko:K22468	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PPK2
k59_76646_1	379066.GAU_3001	4.58e-11	62.8	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,1ZUC3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
k59_1022572_1	269796.Rru_A0566	8.79e-102	327.0	COG0493@1|root,COG0543@1|root,COG0493@2|Bacteria,COG0543@2|Bacteria,1Q44M@1224|Proteobacteria,2V6EC@28211|Alphaproteobacteria,2JQ16@204441|Rhodospirillales	204441|Rhodospirillales	CEH	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
k59_21368_1	671143.DAMO_0182	1.26e-51	181.0	COG1215@1|root,COG1215@2|Bacteria,2NPYF@2323|unclassified Bacteria	2|Bacteria	M	Glycosyl transferase family 21	bcsA	-	2.4.1.12	ko:K00694	ko00500,ko01100,ko02026,map00500,map01100,map02026	-	R02889	RC00005	ko00000,ko00001,ko01000,ko01003,ko02000	4.D.3.1.2,4.D.3.1.5,4.D.3.1.6	GT2	-	Cellulose_synt,Glyco_hydro_26,Glyco_tranf_2_3,Glyco_trans_2_3,Glyco_transf_21,Glycos_transf_2,PilZ
k59_1466846_1	35754.JNYJ01000075_gene8647	1.01e-90	283.0	COG0843@1|root,COG0843@2|Bacteria,2GJHX@201174|Actinobacteria	201174|Actinobacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.9.3.1	ko:K02274,ko:K15408	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1,Cyt_c_ox_IV
k59_911792_1	1430440.MGMSRv2_3789	1.32e-26	107.0	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,2TTXT@28211|Alphaproteobacteria,2JSFC@204441|Rhodospirillales	204441|Rhodospirillales	L	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
k59_1522109_1	926569.ANT_00490	8.69e-67	222.0	COG0433@1|root,COG0433@2|Bacteria,2G62A@200795|Chloroflexi	200795|Chloroflexi	S	Domain of unknown function DUF87	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87,HAS-barrel
k59_131884_1	1191523.MROS_0712	6.33e-100	323.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria	2|Bacteria	E	L-glutamate biosynthetic process	gltB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016020,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_521720_1	1265503.KB905173_gene4133	3.83e-35	135.0	COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,1S1PK@1236|Gammaproteobacteria,2Q8B4@267889|Colwelliaceae	1236|Gammaproteobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_1299935_1	225937.HP15_748	7.96e-111	332.0	COG0554@1|root,COG0554@2|Bacteria,1MUP7@1224|Proteobacteria,1RMAF@1236|Gammaproteobacteria,464DH@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
k59_76680_1	1894.JOER01000012_gene1832	9.89e-18	86.7	COG0204@1|root,COG0204@2|Bacteria,2GQVG@201174|Actinobacteria	201174|Actinobacteria	I	Acyltransferase	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
k59_631940_1	479435.Kfla_0679	2.17e-65	208.0	COG0451@1|root,COG0451@2|Bacteria,2I2EG@201174|Actinobacteria,4DP7C@85009|Propionibacteriales	201174|Actinobacteria	M	RmlD substrate binding domain	-	-	4.2.1.46,5.1.3.2	ko:K01710,ko:K01784	ko00052,ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00052,map00520,map00521,map00523,map00525,map01055,map01100,map01130	M00361,M00362,M00632,M00793	R00291,R02984,R06513	RC00289,RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
k59_631940_2	1232437.KL662077_gene1906	9.98e-19	80.9	COG1555@1|root,COG1555@2|Bacteria,1PU4P@1224|Proteobacteria,42VEG@68525|delta/epsilon subdivisions,2WSQJ@28221|Deltaproteobacteria,2MMC6@213118|Desulfobacterales	28221|Deltaproteobacteria	L	TIGRFAM competence protein ComEA helix-hairpin-helix repeat	-	-	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3
k59_299288_1	1123360.thalar_02390	2.97e-123	361.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2TU72@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve
k59_412356_1	497321.C664_14144	2.61e-78	244.0	COG0075@1|root,COG0075@2|Bacteria,1PM38@1224|Proteobacteria,2VHNM@28216|Betaproteobacteria,2KVAR@206389|Rhodocyclales	206389|Rhodocyclales	E	COG0075 Serine-pyruvate aminotransferase archaeal aspartate aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
k59_1301911_1	1168065.DOK_14974	6.66e-21	95.9	COG3203@1|root,COG3203@2|Bacteria,1R5I5@1224|Proteobacteria,1RM86@1236|Gammaproteobacteria,1J7SJ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	phosphate-selective porin O and P	-	-	-	-	-	-	-	-	-	-	-	-	Porin_4,Porin_O_P
k59_356231_1	348780.NP_2542A	3.78e-15	76.6	COG1071@1|root,arCOG01054@2157|Archaea,2XUWR@28890|Euryarchaeota,23TY6@183963|Halobacteria	183963|Halobacteria	C	COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit	oxdhA2	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
k59_356231_2	323261.Noc_2707	0.000522	43.1	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,1RN5I@1236|Gammaproteobacteria,1WZYZ@135613|Chromatiales	135613|Chromatiales	C	aconitate hydratase	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k59_578524_1	1089552.KI911559_gene2093	5.97e-08	53.5	COG0672@1|root,COG0672@2|Bacteria,1MX1M@1224|Proteobacteria,2TU8Z@28211|Alphaproteobacteria,2JRT0@204441|Rhodospirillales	204441|Rhodospirillales	P	Iron permease FTR1 family	-	-	-	ko:K07243	-	-	-	-	ko00000,ko02000	2.A.108.1,2.A.108.2	-	-	FTR1
k59_578524_2	1163617.SCD_n00303	3.31e-34	122.0	COG4633@1|root,COG4633@2|Bacteria,1N6VB@1224|Proteobacteria,2WHPH@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Cupredoxin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1
k59_968757_1	1449126.JQKL01000021_gene66	3.23e-08	59.7	COG2234@1|root,COG2234@2|Bacteria,1V13T@1239|Firmicutes,24A8F@186801|Clostridia	186801|Clostridia	S	PFAM Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
k59_690892_1	861299.J421_6229	2.78e-80	269.0	COG2373@1|root,COG2373@2|Bacteria	2|Bacteria	U	Large extracellular alpha-helical protein	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,Big_5,MG1,Thiol-ester_cl
k59_356241_1	991905.SL003B_0898	7.69e-43	152.0	COG1360@1|root,COG1360@2|Bacteria,1MU4S@1224|Proteobacteria,2TQKZ@28211|Alphaproteobacteria,4BQ31@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	N	OmpA family	MA20_18060	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	OmpA
k59_1248069_1	1207063.P24_03720	1.62e-80	253.0	COG2252@1|root,COG2252@2|Bacteria,1MUV0@1224|Proteobacteria,2TRC0@28211|Alphaproteobacteria,2JQGH@204441|Rhodospirillales	204441|Rhodospirillales	S	Permease family	-	-	-	ko:K06901	-	-	-	-	ko00000,ko02000	2.A.1.40	-	-	Xan_ur_permease
k59_1024797_1	626887.J057_09836	8.22e-41	151.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,1RN7X@1236|Gammaproteobacteria,4665Q@72275|Alteromonadaceae	1236|Gammaproteobacteria	I	COG1960 Acyl-CoA dehydrogenases	aidB	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003995,GO:0005488,GO:0005515,GO:0006355,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008470,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016491,GO:0016627,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0033554,GO:0042802,GO:0043565,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0055114,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K09456	-	-	-	-	ko00000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M
k59_1468971_1	472759.Nhal_2510	3.82e-59	194.0	COG0604@1|root,COG0604@2|Bacteria,1MV3W@1224|Proteobacteria,1RMHG@1236|Gammaproteobacteria,1WX3U@135613|Chromatiales	135613|Chromatiales	C	PFAM Alcohol dehydrogenase	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_1376171_1	379066.GAU_1915	7.62e-37	142.0	COG0013@1|root,COG0013@2|Bacteria,1ZT18@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
k59_262326_1	209285.XP_006695465.1	1e-50	177.0	COG1104@1|root,KOG1549@2759|Eukaryota,38E7D@33154|Opisthokonta,3NUA7@4751|Fungi,3QMGK@4890|Ascomycota,2165B@147550|Sordariomycetes,3U82E@5139|Sordariales,3HCKG@35718|Chaetomiaceae	4751|Fungi	E	Beta-eliminating lyase	NFS1	GO:0000959,GO:0000963,GO:0002097,GO:0002098,GO:0002143,GO:0003674,GO:0003824,GO:0004123,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006790,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016226,GO:0016740,GO:0016782,GO:0016783,GO:0016829,GO:0016846,GO:0019725,GO:0022607,GO:0030003,GO:0031071,GO:0031163,GO:0031974,GO:0032991,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0042592,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044571,GO:0046483,GO:0046916,GO:0048878,GO:0050801,GO:0051186,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0070013,GO:0070525,GO:0070900,GO:0070903,GO:0071704,GO:0071840,GO:0090304,GO:0090646,GO:0098771,GO:0140053,GO:1900864,GO:1901360,GO:1990221	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
k59_262331_3	639030.JHVA01000001_gene2784	1.96e-07	52.8	COG0577@1|root,COG0577@2|Bacteria,3Y44G@57723|Acidobacteria,2JHKI@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_541287_1	865861.AZSU01000002_gene2791	1.97e-17	85.9	COG1454@1|root,COG1454@2|Bacteria,1TPB4@1239|Firmicutes,247IQ@186801|Clostridia,36EAX@31979|Clostridiaceae	186801|Clostridia	C	alcohol dehydrogenase	-	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
k59_819461_1	926550.CLDAP_37920	1.53e-07	53.5	COG5598@1|root,COG5598@2|Bacteria	2|Bacteria	H	trimethylamine methyltransferase	mttB2	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
k59_1651426_1	926550.CLDAP_02330	1.08e-23	100.0	COG0173@1|root,COG0173@2|Bacteria,2G5RX@200795|Chloroflexi	200795|Chloroflexi	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
k59_1321499_1	290397.Adeh_2071	1.03e-147	431.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,42MAV@68525|delta/epsilon subdivisions,2WJC9@28221|Deltaproteobacteria,2YW7U@29|Myxococcales	28221|Deltaproteobacteria	H	Belongs to the alpha-IPM synthase homocitrate synthase family	cimA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
k59_1431059_1	223926.28806353	1.12e-44	162.0	COG0624@1|root,COG0624@2|Bacteria,1MWJS@1224|Proteobacteria,1RZXV@1236|Gammaproteobacteria,1XVZK@135623|Vibrionales	135623|Vibrionales	E	Peptidase dimerisation domain	-	-	-	ko:K13049	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
k59_151689_1	357808.RoseRS_4106	3.2e-65	204.0	COG0410@1|root,COG0410@2|Bacteria,2G69M@200795|Chloroflexi,374V9@32061|Chloroflexia	32061|Chloroflexia	E	PFAM ABC transporter related	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
k59_151689_2	357808.RoseRS_4107	5.86e-16	77.4	COG0559@1|root,COG0559@2|Bacteria,2GBUW@200795|Chloroflexi,376UV@32061|Chloroflexia	32061|Chloroflexia	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_541305_1	926569.ANT_16590	9.36e-45	150.0	29ATW@1|root,2ZXTA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_320561_1	485913.Krac_9360	2.63e-96	289.0	COG1071@1|root,COG1071@2|Bacteria,2G7RR@200795|Chloroflexi	200795|Chloroflexi	C	PFAM dehydrogenase E1 component	-	-	-	ko:K21416	-	-	-	-	ko00000,ko01000	-	-	-	E1_dh
k59_1762817_1	42565.FP66_03835	9.62e-23	102.0	COG0398@1|root,COG1249@1|root,COG0398@2|Bacteria,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RQTU@1236|Gammaproteobacteria,1XHNV@135619|Oceanospirillales	135619|Oceanospirillales	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim,SNARE_assoc
k59_206315_1	247490.KSU1_B0602	1.17e-42	159.0	COG1672@1|root,COG3064@1|root,COG1672@2|Bacteria,COG3064@2|Bacteria,2IXC3@203682|Planctomycetes	203682|Planctomycetes	M	PFAM Archaeal ATPase	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,WD40
k59_596551_1	448385.sce3029	5.99e-68	221.0	COG0436@1|root,COG0436@2|Bacteria,1QHKS@1224|Proteobacteria,42Z0T@68525|delta/epsilon subdivisions,2WU4I@28221|Deltaproteobacteria,2YTVA@29|Myxococcales	28221|Deltaproteobacteria	E	Aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
k59_933778_1	1248916.ANFY01000017_gene1386	3.72e-05	48.5	COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,2TR03@28211|Alphaproteobacteria,2K1NT@204457|Sphingomonadales	204457|Sphingomonadales	U	Involved in the TonB-independent uptake of proteins	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
k59_206317_1	1123060.JONP01000008_gene4498	1.44e-27	112.0	COG0596@1|root,COG0596@2|Bacteria,1QWWW@1224|Proteobacteria,2U88T@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
k59_1208467_1	340177.Cag_1766	3.72e-74	235.0	COG0601@1|root,COG0601@2|Bacteria,1FDDB@1090|Chlorobi	1090|Chlorobi	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_1376269_1	1379270.AUXF01000001_gene1880	2.38e-16	84.3	COG0823@1|root,COG3629@1|root,COG0823@2|Bacteria,COG3629@2|Bacteria,1ZTSR@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Bacterial transcriptional activator domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	BTAD
k59_374767_1	1121920.AUAU01000006_gene301	9.17e-33	120.0	2BYAB@1|root,32R2Z@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_709718_1	1128421.JAGA01000003_gene3247	2.5e-33	132.0	COG2304@1|root,COG2304@2|Bacteria,2NQHG@2323|unclassified Bacteria	2|Bacteria	S	Aerotolerance regulator N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	BatA,VWA_2
k59_1710976_1	357808.RoseRS_3403	4.23e-60	195.0	COG2120@1|root,COG2120@2|Bacteria,2G6FB@200795|Chloroflexi,375NK@32061|Chloroflexia	32061|Chloroflexia	S	PFAM LmbE family protein	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
k59_1487580_1	1048983.EL17_06760	2.46e-70	224.0	COG3507@1|root,COG3507@2|Bacteria,4NFU3@976|Bacteroidetes,47NII@768503|Cytophagia	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 43 family	-	-	3.2.1.99	ko:K06113	-	-	-	-	ko00000,ko01000	-	GH43	-	Glyco_hydro_43,RicinB_lectin_2
k59_650837_1	1173023.KE650771_gene2908	2.12e-20	93.6	COG1052@1|root,COG1052@2|Bacteria,1G2JB@1117|Cyanobacteria	1117|Cyanobacteria	CH	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.20.1.1	ko:K18916	-	-	-	-	ko00000,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_320626_1	1405.DJ92_304	7.58e-58	190.0	COG0604@1|root,COG0604@2|Bacteria,1TSWF@1239|Firmicutes,4HANV@91061|Bacilli,1ZPZP@1386|Bacillus	91061|Bacilli	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
k59_541382_2	926569.ANT_22320	2.25e-47	166.0	COG1559@1|root,COG1559@2|Bacteria,2G6G8@200795|Chloroflexi	200795|Chloroflexi	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
k59_763563_2	67332.FM21_13525	2.61e-06	52.4	COG0709@1|root,COG0709@2|Bacteria,2GNP4@201174|Actinobacteria	201174|Actinobacteria	E	Synthesizes selenophosphate from selenide and ATP	selD	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C
k59_262445_2	383372.Rcas_0210	7.53e-21	92.0	COG0714@1|root,COG0714@2|Bacteria,2G66D@200795|Chloroflexi,374V5@32061|Chloroflexia	32061|Chloroflexia	S	ATPase associated with various cellular activities, AAA_5	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
k59_1376352_1	492774.JQMB01000007_gene4175	3.53e-52	189.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4B9BA@82115|Rhizobiaceae	1224|Proteobacteria	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,TPR_2,TPR_8,Trans_reg_C
k59_874586_1	1205680.CAKO01000029_gene5244	7.33e-06	45.8	COG0757@1|root,COG0757@2|Bacteria,1NXE4@1224|Proteobacteria	1224|Proteobacteria	E	Dehydroquinase class II	-	-	-	-	-	-	-	-	-	-	-	-	DHquinase_II
k59_874586_2	1380394.JADL01000013_gene627	2.15e-16	79.7	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2U43D@28211|Alphaproteobacteria,2JW7C@204441|Rhodospirillales	204441|Rhodospirillales	IQ	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
k59_541423_1	1397666.RS24_01522	8.65e-114	337.0	COG1960@1|root,COG1960@2|Bacteria,1MX17@1224|Proteobacteria,2TTRE@28211|Alphaproteobacteria,4BRHN@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	ko:K18244	-	-	-	-	ko00000,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_1431175_2	1089551.KE386572_gene1162	1.28e-48	164.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	2.1.1.197	ko:K02169	ko00780,ko01100,map00780,map01100	M00572	R09543	RC00003,RC00460	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11
k59_1711098_1	111780.Sta7437_2617	4.96e-83	271.0	COG0045@1|root,COG1042@1|root,COG1670@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1670@2|Bacteria,1G2D3@1117|Cyanobacteria,3VIFN@52604|Pleurocapsales	1117|Cyanobacteria	CJ	TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain	-	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
k59_1098230_1	991905.SL003B_2331	9.82e-85	258.0	COG0785@1|root,COG0785@2|Bacteria,1RCP7@1224|Proteobacteria,2TSAI@28211|Alphaproteobacteria,4BQ9P@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	O	Cytochrome C biogenesis protein transmembrane region	ccdA	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	DsbD
k59_1651526_1	926550.CLDAP_11020	1.85e-77	243.0	COG1173@1|root,COG1173@2|Bacteria,2G841@200795|Chloroflexi	2|Bacteria	P	Binding-protein-dependent transport system inner membrane component	oppC	-	-	ko:K02034,ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1,OppC_N
k59_1376411_1	1174528.JH992893_gene6054	4.78e-40	150.0	COG0318@1|root,COG0318@2|Bacteria	2|Bacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
k59_1098237_2	985255.APHJ01000021_gene1614	4.2e-06	50.4	COG1011@1|root,COG1011@2|Bacteria,4NHRZ@976|Bacteroidetes,1HZUS@117743|Flavobacteriia,2P6WJ@244698|Gillisia	976|Bacteroidetes	S	Haloacid dehalogenase-like hydrolase	-	-	3.8.1.2	ko:K01560	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	HAD_2
k59_596631_2	587753.EY04_14365	2.04e-08	58.2	COG2079@1|root,COG2079@2|Bacteria,1R5UM@1224|Proteobacteria,1RS1P@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein involved in propionate catabolism	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
k59_1487724_1	694429.Pyrfu_1952	8.2e-22	94.7	COG0500@1|root,arCOG01631@2157|Archaea,2XR0B@28889|Crenarchaeota	28889|Crenarchaeota	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	DOT1
k59_96861_1	1828.JOKB01000062_gene5489	3.02e-30	114.0	COG0789@1|root,COG0789@2|Bacteria,2GM67@201174|Actinobacteria,4FWQN@85025|Nocardiaceae	201174|Actinobacteria	K	helix_turn_helix, mercury resistance	merR2	-	-	-	-	-	-	-	-	-	-	-	MerR_1
k59_596636_1	1282876.BAOK01000001_gene1616	4.75e-75	233.0	COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,2TRIH@28211|Alphaproteobacteria,4BQEZ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase/isomerase	MA20_16365	-	4.2.1.149	ko:K08299	-	-	R10675	RC01095	ko00000,ko01000	-	-	-	ECH_1
k59_1711118_1	1408422.JHYF01000011_gene3454	1.86e-18	90.9	COG1228@1|root,COG1228@2|Bacteria,1TPNQ@1239|Firmicutes,248UT@186801|Clostridia,36E56@31979|Clostridiaceae	186801|Clostridia	Q	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,Amidohydro_3
k59_1711130_1	395494.Galf_1617	4.66e-20	94.4	COG0492@1|root,COG0664@1|root,COG1142@1|root,COG0492@2|Bacteria,COG0664@2|Bacteria,COG1142@2|Bacteria,1PPH1@1224|Proteobacteria,2W9GU@28216|Betaproteobacteria,44WKA@713636|Nitrosomonadales	28216|Betaproteobacteria	C	FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_3
k59_1208614_1	1300143.CCAV010000001_gene1530	1.85e-08	57.8	COG1680@1|root,COG1680@2|Bacteria,4NGKK@976|Bacteroidetes,1HX0I@117743|Flavobacteriia,3ZSG5@59732|Chryseobacterium	976|Bacteroidetes	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_1762944_1	1499967.BAYZ01000028_gene1309	4.77e-63	199.0	COG0410@1|root,COG0410@2|Bacteria,2NNXF@2323|unclassified Bacteria	2|Bacteria	E	ABC transporter	livF	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
k59_206421_1	1089549.AZUQ01000001_gene1861	4.95e-26	106.0	COG0106@1|root,COG0106@2|Bacteria,2GJ4V@201174|Actinobacteria,4EY76@85014|Glycomycetales	201174|Actinobacteria	E	Histidine biosynthesis protein	hisA	GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.16,5.3.1.24	ko:K01814,ko:K01817	ko00340,ko00400,ko01100,ko01110,ko01130,ko01230,map00340,map00400,map01100,map01110,map01130,map01230	M00023,M00026	R03509,R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
k59_650979_1	1123299.AUKZ01000004_gene384	1.09e-07	53.1	COG0082@1|root,COG0082@2|Bacteria,1TQ40@1239|Firmicutes,4HA0H@91061|Bacilli	91061|Bacilli	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
k59_1046927_1	1089551.KE386572_gene601	4.56e-21	87.0	COG0695@1|root,COG0695@2|Bacteria,1N72P@1224|Proteobacteria,2UFM1@28211|Alphaproteobacteria,4BQSB@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	O	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins	grxC	-	-	ko:K03676	-	-	-	-	ko00000,ko03110	-	-	-	Glutaredoxin
k59_154651_1	861299.J421_5896	1.08e-34	136.0	COG0577@1|root,COG0577@2|Bacteria	861299.J421_5896|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1046928_1	105559.Nwat_1881	4.19e-09	58.5	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,1RNN0@1236|Gammaproteobacteria,1WX6R@135613|Chromatiales	135613|Chromatiales	E	PFAM Aminotransferase class I and II	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_43007_1	702113.PP1Y_AT11408	5.51e-11	68.2	COG2010@1|root,COG4993@1|root,COG2010@2|Bacteria,COG4993@2|Bacteria,1R7EM@1224|Proteobacteria,2UPM6@28211|Alphaproteobacteria,2K9IJ@204457|Sphingomonadales	204457|Sphingomonadales	C	PQQ-like domain	-	-	1.1.9.1	ko:K17760	-	-	-	-	ko00000,ko01000	-	-	-	Cytochrome_CBB3,PQQ
k59_1765800_1	309801.trd_0620	1.32e-22	99.4	COG1606@1|root,COG1606@2|Bacteria,2G6AU@200795|Chloroflexi	200795|Chloroflexi	L	tRNA processing	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	Asn_synthase,NAD_synthase
k59_1324474_2	1169143.KB911037_gene3980	3.37e-51	178.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,2W6VF@28216|Betaproteobacteria,1KCVK@119060|Burkholderiaceae	28216|Betaproteobacteria	H	3-octaprenyl-4-hydroxybenzoate carboxy-lyase	-	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
k59_877445_1	526225.Gobs_2142	1.75e-15	77.4	COG3391@1|root,COG4995@1|root,COG3391@2|Bacteria,COG4995@2|Bacteria,2HF98@201174|Actinobacteria,4EWDJ@85013|Frankiales	201174|Actinobacteria	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_99593_1	234267.Acid_5940	1.54e-30	127.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria	57723|Acidobacteria	KLTU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
k59_936663_1	926569.ANT_18530	8.18e-62	193.0	COG0691@1|root,COG0691@2|Bacteria,2G6NE@200795|Chloroflexi	200795|Chloroflexi	J	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
k59_1269833_1	797515.HMPREF9103_01946	1.27e-43	155.0	COG0337@1|root,COG0337@2|Bacteria,1TPKZ@1239|Firmicutes,4HAKN@91061|Bacilli,3F4JH@33958|Lactobacillaceae	91061|Bacilli	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	4.2.3.4	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03083	RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
k59_377739_1	1458357.BG58_11825	2.48e-12	71.6	COG2079@1|root,COG2079@2|Bacteria,1R5UM@1224|Proteobacteria,2VI2F@28216|Betaproteobacteria,1K5T8@119060|Burkholderiaceae	28216|Betaproteobacteria	S	MmgE PrpD family protein	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
k59_439631_1	1168034.FH5T_04795	2.24e-73	226.0	COG0207@1|root,COG0207@2|Bacteria,4NEC2@976|Bacteroidetes,2FM46@200643|Bacteroidia	976|Bacteroidetes	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	thyA	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
k59_439631_2	1523503.JPMY01000006_gene2154	2.45e-17	77.4	COG0262@1|root,COG0262@2|Bacteria,1RH0P@1224|Proteobacteria,1S5VH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis	folA	GO:0000166,GO:0003674,GO:0003824,GO:0004146,GO:0005488,GO:0005542,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008144,GO:0008150,GO:0008152,GO:0016491,GO:0016645,GO:0016646,GO:0019842,GO:0031406,GO:0033218,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043177,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050661,GO:0050662,GO:0050896,GO:0051870,GO:0051871,GO:0055114,GO:0070401,GO:0070402,GO:0072341,GO:0097159,GO:1901265,GO:1901363	1.5.1.3	ko:K00287,ko:K18590	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	M00126,M00840	R00936,R00937,R00939,R00940,R02235,R02236,R11765	RC00109,RC00110,RC00158	br01600,ko00000,ko00001,ko00002,ko01000,ko01504	-	-	iECBD_1354.ECBD_3567,iECDH1ME8569_1439.ECDH1ME8569_0047,iECNA114_1301.ECNA114_0036,iEcDH1_1363.EcDH1_3551,iEcSMS35_1347.EcSMS35_0050,iG2583_1286.G2583_0050,iJN746.PP_5132,iNRG857_1313.NRG857_00250,iUMN146_1321.UM146_23020	DHFR_1
k59_1277678_1	1121918.ARWE01000001_gene152	1.62e-10	68.9	COG0144@1|root,COG0144@2|Bacteria,1MWPE@1224|Proteobacteria,42P2T@68525|delta/epsilon subdivisions,2WJ9B@28221|Deltaproteobacteria,43S8A@69541|Desulfuromonadales	28221|Deltaproteobacteria	JK	16S rRNA methyltransferase RsmB/F	rsmB	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N,NusB
k59_1498279_1	1297742.A176_05625	3.11e-46	160.0	COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,42MIA@68525|delta/epsilon subdivisions,2WJJA@28221|Deltaproteobacteria,2YU86@29|Myxococcales	28221|Deltaproteobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696,ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_1498279_2	889378.Spiaf_2549	1.01e-05	47.8	COG0134@1|root,COG0135@1|root,COG0134@2|Bacteria,COG0135@2|Bacteria,2J5XH@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the	trpF	-	4.1.1.48,5.3.1.24	ko:K01609,ko:K13498	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508,R03509	RC00944,RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS,PRAI
k59_659652_1	713587.THITH_12925	1.77e-35	135.0	COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,1RPJB@1236|Gammaproteobacteria,1WW6G@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_828911_1	1386089.N865_16745	1.34e-70	236.0	COG2304@1|root,COG3591@1|root,COG2304@2|Bacteria,COG3591@2|Bacteria,2HFMP@201174|Actinobacteria,4FJNH@85021|Intrasporangiaceae	201174|Actinobacteria	E	von Willebrand factor type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2
k59_1773378_1	452637.Oter_1803	1.36e-77	251.0	COG4263@1|root,COG4263@2|Bacteria,46YT5@74201|Verrucomicrobia,3K7SZ@414999|Opitutae	414999|Opitutae	C	Cupredoxin-like domain	-	-	1.7.2.4	ko:K00376	ko00910,ko01120,map00910,map01120	M00529	R02804	RC02861	ko00000,ko00001,ko00002,ko01000	-	-	-	Cupredoxin_1
k59_772022_1	999611.KI421504_gene674	3.24e-25	103.0	COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,2TSJY@28211|Alphaproteobacteria,27ZPU@191028|Leisingera	28211|Alphaproteobacteria	H	S-adenosyl-L-homocysteine hydrolase, NAD binding domain	ahcY	GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
k59_772022_2	1038867.AXAY01000012_gene216	3.07e-44	152.0	COG1024@1|root,COG1024@2|Bacteria,1MWGT@1224|Proteobacteria,2TV7F@28211|Alphaproteobacteria,3JU1Q@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	MA20_40055	-	-	-	-	-	-	-	-	-	-	-	ECH_1
k59_550328_1	864051.BurJ1DRAFT_3478	1.71e-19	94.0	COG1174@1|root,COG1732@1|root,COG1174@2|Bacteria,COG1732@2|Bacteria,1QWXX@1224|Proteobacteria,2WHFU@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K05846	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1
k59_1217422_1	713587.THITH_14480	8.02e-90	278.0	COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,1RNIG@1236|Gammaproteobacteria,1WWBT@135613|Chromatiales	135613|Chromatiales	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
k59_105941_1	357808.RoseRS_3742	2.92e-18	87.4	COG1131@1|root,COG1131@2|Bacteria,2G7S9@200795|Chloroflexi,376VX@32061|Chloroflexia	32061|Chloroflexia	V	PFAM ABC transporter related	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
k59_49614_1	29540.C481_20726	4.32e-12	70.5	arCOG10131@1|root,arCOG10131@2157|Archaea,2XWNY@28890|Euryarchaeota,23V3W@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_105952_1	631454.N177_0505	4.94e-40	147.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TTM5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR). Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate	frc	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
k59_1773413_1	1150469.RSPPHO_01567	1.51e-94	292.0	COG0804@1|root,COG0804@2|Bacteria,1MU5P@1224|Proteobacteria,2TSXP@28211|Alphaproteobacteria,2JQBW@204441|Rhodospirillales	204441|Rhodospirillales	E	Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family	ureC	-	3.5.1.5	ko:K01428	ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120	-	R00131	RC02798,RC02806	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1,Urease_alpha
k59_331502_1	595460.RRSWK_05140	1.24e-22	100.0	28JVS@1|root,2Z9KP@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1277723_1	665956.HMPREF1032_00420	1e-24	102.0	COG1533@1|root,COG1533@2|Bacteria,1TSS2@1239|Firmicutes,248SB@186801|Clostridia,3WH7N@541000|Ruminococcaceae	186801|Clostridia	L	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
k59_1607539_1	240015.ACP_3466	2.88e-39	144.0	COG0028@1|root,COG0028@2|Bacteria,3Y3GJ@57723|Acidobacteria,2JI90@204432|Acidobacteriia	204432|Acidobacteriia	EH	Acetolactate synthase, large subunit	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_1607539_2	999419.HMPREF1077_02292	7.41e-08	54.7	COG0129@1|root,COG0129@2|Bacteria,4NFHP@976|Bacteroidetes,2FMCC@200643|Bacteroidia,22WXM@171551|Porphyromonadaceae	976|Bacteroidetes	EG	Belongs to the IlvD Edd family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
k59_550351_1	243090.RB13131	1.5e-95	296.0	COG2010@1|root,COG2133@1|root,COG2010@2|Bacteria,COG2133@2|Bacteria,2IXUJ@203682|Planctomycetes	203682|Planctomycetes	G	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
k59_604650_1	1033802.SSPSH_002378	8.93e-27	114.0	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,1RM9X@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019538,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034645,GO:0036094,GO:0043021,GO:0043024,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0097159,GO:0097216,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc
k59_1440682_1	1121434.AULY01000011_gene1816	2.82e-10	65.1	COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,42MPK@68525|delta/epsilon subdivisions,2WJM1@28221|Deltaproteobacteria,2M7YN@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	PFAM PpiC-type peptidyl-prolyl cis-trans isomerase	nifM	-	5.2.1.8	ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
k59_659706_1	485913.Krac_12092	3.61e-97	299.0	COG4799@1|root,COG4799@2|Bacteria,2G5IX@200795|Chloroflexi	200795|Chloroflexi	I	PFAM carboxyl transferase	-	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_1165009_1	261292.Nit79A3_0138	1.85e-137	400.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1MW7X@1224|Proteobacteria,2VMDX@28216|Betaproteobacteria	28216|Betaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_23,HTH_32
k59_1719195_1	671143.DAMO_2335	2.43e-44	156.0	COG0248@1|root,COG0248@2|Bacteria,2NPR1@2323|unclassified Bacteria	2|Bacteria	FP	Ppx/GppA phosphatase family	ppx	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006793,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0040007,GO:0044237,GO:0044464,GO:0071944	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
k59_1332482_1	1157638.KB892209_gene1102	1.51e-23	97.4	COG2141@1|root,COG2141@2|Bacteria,2GJRF@201174|Actinobacteria	201174|Actinobacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_1332482_2	1038858.AXBA01000014_gene2290	5.61e-17	82.4	COG0384@1|root,COG0384@2|Bacteria,1MUAS@1224|Proteobacteria,2U3ND@28211|Alphaproteobacteria,3EXXU@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	phenazine biosynthesis protein	phzF	-	5.3.3.17	ko:K06998	ko00405,ko01130,ko02024,map00405,map01130,map02024	M00835	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	PhzC-PhzF
k59_1661449_1	1313172.YM304_28350	8.31e-24	103.0	COG4585@1|root,COG4585@2|Bacteria,2GMMU@201174|Actinobacteria,4CP52@84992|Acidimicrobiia	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
k59_1386859_1	1121346.KB899811_gene1587	1.16e-57	191.0	COG0181@1|root,COG0181@2|Bacteria,1TPFQ@1239|Firmicutes,4H9TV@91061|Bacilli,26RBP@186822|Paenibacillaceae	91061|Bacilli	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
k59_1661459_2	324057.Pjdr2_3358	1.93e-17	79.0	2D7FD@1|root,32TNY@2|Bacteria,1VADP@1239|Firmicutes,4HKCW@91061|Bacilli,26YY4@186822|Paenibacillaceae	91061|Bacilli	S	Molecular chaperone DnaJ	ydhN1	-	-	-	-	-	-	-	-	-	-	-	DUF1992
k59_943457_1	641491.DND132_2594	5.77e-25	98.6	COG2885@1|root,COG2885@2|Bacteria,1MZKA@1224|Proteobacteria,42UAP@68525|delta/epsilon subdivisions,2WQWJ@28221|Deltaproteobacteria,2MCJW@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	PFAM OmpA MotB domain protein	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
k59_772093_1	861299.J421_3141	2.08e-75	231.0	COG2065@1|root,COG2065@2|Bacteria,1ZTHG@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant	pyrR	-	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000,ko03000	-	-	-	Pribosyltran
k59_1165053_1	69395.JQLZ01000003_gene122	9.71e-14	75.5	COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,2TRY7@28211|Alphaproteobacteria,2KG2V@204458|Caulobacterales	204458|Caulobacterales	H	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	-	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
k59_1389003_1	1469245.JFBG01000011_gene830	1.97e-75	230.0	COG0740@1|root,COG0740@2|Bacteria,1MV46@1224|Proteobacteria,1RNR6@1236|Gammaproteobacteria,1WW24@135613|Chromatiales	135613|Chromatiales	OU	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
k59_773702_2	543913.D521_0701	9.95e-28	112.0	COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,2VJ29@28216|Betaproteobacteria,1KPVU@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III	algC	GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005488,GO:0005975,GO:0005976,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009243,GO:0009244,GO:0009311,GO:0009312,GO:0009405,GO:0009987,GO:0016051,GO:0016053,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0042120,GO:0042121,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044419,GO:0046394,GO:0046401,GO:0046402,GO:0046872,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	5.4.2.2,5.4.2.8	ko:K01835,ko:K01840,ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114,M00549	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_773705_2	439481.Aboo_1012	1.12e-42	144.0	COG1096@1|root,arCOG00676@2157|Archaea	2157|Archaea	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs	csl4	-	-	ko:K07573	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	ECR1_N,EXOSC1
k59_1663097_1	383372.Rcas_3864	4.3e-10	65.9	COG5316@1|root,COG5316@2|Bacteria,2GBUR@200795|Chloroflexi,375C5@32061|Chloroflexia	32061|Chloroflexia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1663103_1	331869.BAL199_14432	5.48e-48	164.0	COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria	1224|Proteobacteria	T	Exporters of the RND superfamily	VP1286	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
k59_107662_1	1462527.CCDM010000006_gene4477	4.26e-86	261.0	COG0656@1|root,COG0656@2|Bacteria,1TPM1@1239|Firmicutes,4HARE@91061|Bacilli,23JC2@182709|Oceanobacillus	91061|Bacilli	S	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_1167217_1	1469613.JT55_12095	1.7e-33	124.0	COG3647@1|root,COG3647@2|Bacteria,1RGJN@1224|Proteobacteria,2U80P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_606297_1	1068980.ARVW01000001_gene1983	2e-28	119.0	COG1615@1|root,COG1615@2|Bacteria,2GMP3@201174|Actinobacteria,4E04T@85010|Pseudonocardiales	201174|Actinobacteria	S	PFAM Uncharacterised protein family UPF0182	-	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
k59_1442736_1	118163.Ple7327_1373	9.36e-98	296.0	COG2227@1|root,COG2227@2|Bacteria,1G06X@1117|Cyanobacteria,3VJGG@52604|Pleurocapsales	1117|Cyanobacteria	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_13,Methyltransf_14,Methyltransf_23
k59_272569_1	1122194.AUHU01000008_gene3384	1.24e-07	53.5	COG2303@1|root,COG2303@2|Bacteria,1MU3F@1224|Proteobacteria,1RPBQ@1236|Gammaproteobacteria,463YB@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	Oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
k59_272569_2	338969.Rfer_3509	7.32e-34	130.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2VJ55@28216|Betaproteobacteria,4AAYC@80864|Comamonadaceae	28216|Betaproteobacteria	H	TIGRFAM acetolactate synthase, large subunit, biosynthetic type	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_1389087_1	65393.PCC7424_4516	9.84e-68	217.0	COG1090@1|root,COG1090@2|Bacteria,1G1NR@1117|Cyanobacteria,3KGKQ@43988|Cyanothece	1117|Cyanobacteria	S	NAD-dependent epimerase dehydratase	-	-	-	ko:K07071	-	-	-	-	ko00000	-	-	-	DUF1731,Epimerase
k59_1109864_1	1173020.Cha6605_0948	5.73e-29	119.0	COG2203@1|root,COG5002@1|root,COG2203@2|Bacteria,COG5002@2|Bacteria,1G3VN@1117|Cyanobacteria	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS,PAS_9
k59_1219030_1	485913.Krac_8363	7.53e-49	165.0	COG1662@1|root,COG3677@1|root,COG1662@2|Bacteria,COG3677@2|Bacteria,2G9MB@200795|Chloroflexi	200795|Chloroflexi	L	Putative ATPase subunit of terminase (gpP-like)	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23
k59_1055657_1	1385512.N784_07115	1.66e-06	53.5	COG2201@1|root,COG2201@2|Bacteria,1TRHC@1239|Firmicutes,4HBJY@91061|Bacilli,2Y8XN@289201|Pontibacillus	91061|Bacilli	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	cheB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
k59_1775875_1	1280953.HOC_02291	2.09e-43	161.0	COG2091@1|root,COG2091@2|Bacteria,1MY8E@1224|Proteobacteria,2V4NX@28211|Alphaproteobacteria,43YZT@69657|Hyphomonadaceae	28211|Alphaproteobacteria	H	Carbohydrate family 9 binding domain-like	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
k59_272603_1	1122214.AQWH01000060_gene56	7.69e-68	222.0	COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,2TS8W@28211|Alphaproteobacteria,2PJFP@255475|Aurantimonadaceae	28211|Alphaproteobacteria	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
k59_831168_1	864051.BurJ1DRAFT_3207	7.47e-50	173.0	COG0399@1|root,COG0399@2|Bacteria,1MUMJ@1224|Proteobacteria,2VQRJ@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Putative transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
k59_1500647_1	626887.J057_12021	1.55e-31	125.0	COG0366@1|root,COG0366@2|Bacteria,1MVQA@1224|Proteobacteria,1RPA4@1236|Gammaproteobacteria,46654@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	COG0366 Glycosidases	-	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amyl_C2,Alpha-amylase,Alpha-amylase_C,CBM26,CBM_20,CBM_48,PKD
k59_386505_1	1121017.AUFG01000001_gene3012	5.59e-12	68.6	COG0454@1|root,COG0454@2|Bacteria,COG0456@2|Bacteria,2I0BW@201174|Actinobacteria,4FHU4@85021|Intrasporangiaceae	201174|Actinobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_1551319_1	1132855.KB913035_gene350	1.77e-96	294.0	COG0530@1|root,COG0530@2|Bacteria,1PMXR@1224|Proteobacteria,2VNME@28216|Betaproteobacteria,2KM61@206350|Nitrosomonadales	206350|Nitrosomonadales	P	PFAM sodium calcium exchanger	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
k59_1775935_1	1397284.AYMN01000055_gene2440	7.95e-14	75.1	COG0671@1|root,COG0671@2|Bacteria,1RF0K@1224|Proteobacteria,1S3VZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	PAP2 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PAP2_3
k59_1219077_1	1081644.IMCC13023_13440	4.57e-74	230.0	COG1173@1|root,COG1173@2|Bacteria,2GKAW@201174|Actinobacteria,4FMDF@85023|Microbacteriaceae	201174|Actinobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
k59_722700_1	83406.HDN1F_14270	1.39e-102	314.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,1RNV1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N
k59_888177_1	1207063.P24_12776	1.12e-52	172.0	COG0088@1|root,COG0088@2|Bacteria,1MXPF@1224|Proteobacteria,2TRUT@28211|Alphaproteobacteria,2JQ5X@204441|Rhodospirillales	204441|Rhodospirillales	J	Forms part of the polypeptide exit tunnel	rplD	-	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
k59_888177_2	1238182.C882_0614	1.87e-44	146.0	COG0089@1|root,COG0089@2|Bacteria,1MZXX@1224|Proteobacteria,2UBQ1@28211|Alphaproteobacteria,2JT6W@204441|Rhodospirillales	204441|Rhodospirillales	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	-	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
k59_888177_3	631454.N177_0734	8.33e-43	147.0	COG0090@1|root,COG0090@2|Bacteria,1MVTD@1224|Proteobacteria,2TTKD@28211|Alphaproteobacteria,1JNG3@119043|Rhodobiaceae	28211|Alphaproteobacteria	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
k59_888182_1	861299.J421_5759	7.9e-58	200.0	COG0515@1|root,COG5616@1|root,COG0515@2|Bacteria,COG5616@2|Bacteria,1ZUKV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
k59_442035_2	1215092.PA6_024_00760	1.94e-77	251.0	COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,1RQ4N@1236|Gammaproteobacteria,1YCZP@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	Q	Multicopper oxidase	copA2	-	-	-	-	-	-	-	-	-	-	-	CopB,Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
k59_831224_1	502025.Hoch_3168	3.52e-05	50.1	COG3264@1|root,COG3264@2|Bacteria,1QUBW@1224|Proteobacteria,43CNJ@68525|delta/epsilon subdivisions,2X7VW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Mechanosensitive ion channel	-	-	-	ko:K03442	-	-	-	-	ko00000,ko02000	1.A.23.2	-	-	MS_channel
k59_107777_1	1121468.AUBR01000054_gene1439	4.93e-87	270.0	COG3829@1|root,COG3829@2|Bacteria,1V0EF@1239|Firmicutes,24DXA@186801|Clostridia	186801|Clostridia	KT	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS_9,Sigma54_activat
k59_552047_2	1380387.JADM01000013_gene1411	5.81e-62	206.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,1RM8E@1236|Gammaproteobacteria,1XIET@135619|Oceanospirillales	135619|Oceanospirillales	G	C4-dicarboxylate ABC transporter permease	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_1389204_1	1380370.JIBA01000014_gene1737	1.05e-13	72.0	COG0484@1|root,COG0484@2|Bacteria,2GK69@201174|Actinobacteria,4FFAW@85021|Intrasporangiaceae	201174|Actinobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
k59_1389204_2	383372.Rcas_2163	1.08e-15	77.4	COG0631@1|root,COG0631@2|Bacteria,2G8RD@200795|Chloroflexi,375G5@32061|Chloroflexia	32061|Chloroflexia	T	protein phosphatase 2C domain protein	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
k59_1167359_1	1379270.AUXF01000002_gene1755	5.97e-69	225.0	COG1626@1|root,COG1626@2|Bacteria,1ZUQP@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Trehalase	-	-	3.2.1.28	ko:K01194	ko00500,ko01100,map00500,map01100	-	R00010	RC00049	ko00000,ko00001,ko00537,ko01000	-	GH37	-	Trehalase
k59_1663228_1	459495.SPLC1_S033910	0.000986	45.4	COG0438@1|root,COG1215@1|root,COG1216@1|root,COG0438@2|Bacteria,COG1215@2|Bacteria,COG1216@2|Bacteria,1G2A7@1117|Cyanobacteria,1H9SV@1150|Oscillatoriales	1117|Cyanobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1,Glycos_transf_2
k59_1167360_1	682795.AciX8_3558	2.26e-23	103.0	COG1506@1|root,COG1506@2|Bacteria,3Y6MJ@57723|Acidobacteria,2JMBK@204432|Acidobacteriia	204432|Acidobacteriia	E	Tannase and feruloyl esterase	-	-	-	-	-	-	-	-	-	-	-	-	Tannase
k59_1680471_2	935848.JAEN01000013_gene4025	5.7e-09	56.6	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TR1I@28211|Alphaproteobacteria,2PU94@265|Paracoccus	28211|Alphaproteobacteria	E	Thiamine pyrophosphate enzyme, central domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_12894_1	1144275.COCOR_02328	1.37e-37	140.0	COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,42M1W@68525|delta/epsilon subdivisions,2WPYW@28221|Deltaproteobacteria,2Z30A@29|Myxococcales	28221|Deltaproteobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_12894_2	1121013.P873_12755	2.39e-12	65.9	COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,1RN64@1236|Gammaproteobacteria,1X4CK@135614|Xanthomonadales	135614|Xanthomonadales	K	Belongs to the sigma-70 factor family. ECF subfamily	rpoE	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_623939_1	236097.ADG881_3053	6.32e-09	58.9	COG1047@1|root,COG1047@2|Bacteria,1RGXG@1224|Proteobacteria,1S6XS@1236|Gammaproteobacteria,1XJVV@135619|Oceanospirillales	135619|Oceanospirillales	G	Peptidyl-prolyl cis-trans	-	-	5.2.1.8	ko:K03775	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
k59_623939_2	246197.MXAN_2742	1.61e-27	112.0	COG1166@1|root,COG1166@2|Bacteria,1MU80@1224|Proteobacteria,42M2B@68525|delta/epsilon subdivisions,2WJDZ@28221|Deltaproteobacteria,2YTWQ@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the biosynthesis of agmatine from arginine	speA	-	4.1.1.19	ko:K01585	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N
k59_235334_1	234267.Acid_3874	1.15e-76	243.0	COG3185@1|root,COG3185@2|Bacteria,3Y2XN@57723|Acidobacteria	57723|Acidobacteria	E	Acyclic terpene utilisation family protein AtuA	-	-	-	-	-	-	-	-	-	-	-	-	AtuA
k59_735869_1	290398.Csal_2868	3.22e-17	80.9	COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,1RP1T@1236|Gammaproteobacteria,1XIP5@135619|Oceanospirillales	135619|Oceanospirillales	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
k59_735869_2	870187.Thini_2517	1.25e-44	150.0	COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,1S247@1236|Gammaproteobacteria,460SD@72273|Thiotrichales	72273|Thiotrichales	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
k59_735881_1	1313172.YM304_32450	1.92e-44	152.0	COG1285@1|root,COG1285@2|Bacteria,2GJF0@201174|Actinobacteria,4CP2B@84992|Acidimicrobiia	84992|Acidimicrobiia	S	MgtC family	-	-	-	ko:K07507	-	-	-	-	ko00000,ko02000	9.B.20	-	-	MgtC
k59_902862_1	351627.Csac_2283	0.000949	39.3	COG0185@1|root,COG0185@2|Bacteria,1V6CX@1239|Firmicutes,24JN3@186801|Clostridia,42GJK@68295|Thermoanaerobacterales	186801|Clostridia	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	-	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
k59_902862_2	886293.Sinac_0482	3.04e-67	213.0	COG0090@1|root,COG0090@2|Bacteria,2IXD9@203682|Planctomycetes	203682|Planctomycetes	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
k59_1680514_1	643473.KB235930_gene2340	7.53e-36	133.0	COG0310@1|root,COG0310@2|Bacteria,1G40K@1117|Cyanobacteria,1HIGH@1161|Nostocales	1117|Cyanobacteria	P	PFAM Cobalt uptake substrate-specific transmembrane region	cbiM	-	-	ko:K02007	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiM,PDGLE
k59_1680514_2	1120958.AULD01000001_gene10	9.91e-15	76.6	COG1062@1|root,COG1062@2|Bacteria,2GM8C@201174|Actinobacteria,4FM5F@85023|Microbacteriaceae	201174|Actinobacteria	C	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_1180291_1	760142.Hipma_0545	4.15e-57	192.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,42N8U@68525|delta/epsilon subdivisions,2WJAN@28221|Deltaproteobacteria,2M6K7@213113|Desulfurellales	28221|Deltaproteobacteria	C	Belongs to the citrate synthase family	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
k59_1291294_1	357808.RoseRS_1744	1.24e-41	154.0	COG1232@1|root,COG1232@2|Bacteria,2G687@200795|Chloroflexi,375MK@32061|Chloroflexia	32061|Chloroflexia	H	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX	-	-	1.3.3.15,1.3.3.4	ko:K00231	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03222,R04178	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
k59_291019_1	525904.Tter_0968	3.42e-72	230.0	COG0489@1|root,COG0489@2|Bacteria,2NNX1@2323|unclassified Bacteria	2|Bacteria	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	mrp	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
k59_1291308_1	110662.Syncc9605_0877	1.9e-34	132.0	COG0482@1|root,COG0482@2|Bacteria,1G21J@1117|Cyanobacteria,1GYQI@1129|Synechococcus	1117|Cyanobacteria	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
k59_1736030_1	1126627.BAWE01000004_gene4653	9.27e-99	304.0	COG0457@1|root,COG0457@2|Bacteria,1N0A9@1224|Proteobacteria,2TTMN@28211|Alphaproteobacteria,3JRNE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_2,TPR_8
k59_902889_1	1392502.JNIO01000002_gene140	5.44e-09	64.7	COG0841@1|root,COG0841@2|Bacteria,1TQ03@1239|Firmicutes,4H20U@909932|Negativicutes	909932|Negativicutes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_846265_1	1469607.KK073768_gene1009	3.48e-23	104.0	COG3039@1|root,COG3039@2|Bacteria,1G3YX@1117|Cyanobacteria	1117|Cyanobacteria	L	COG3039 Transposase and inactivated derivatives, IS5 family	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
k59_457947_1	1408473.JHXO01000001_gene2365	7.93e-39	152.0	COG0532@1|root,COG0532@2|Bacteria,4NGP3@976|Bacteroidetes,2FM01@200643|Bacteroidia	976|Bacteroidetes	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N
k59_1180325_1	1245469.S58_18740	3.29e-97	300.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2TS7G@28211|Alphaproteobacteria,3JSN6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter	chvD	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_Xtn
k59_1569512_1	1265505.ATUG01000001_gene4129	8.59e-07	53.9	COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,1MVI9@1224|Proteobacteria,42NB4@68525|delta/epsilon subdivisions,2WK9E@28221|Deltaproteobacteria,2MHUB@213118|Desulfobacterales	28221|Deltaproteobacteria	D	G-rich domain on putative tyrosine kinase	wzc2	-	-	ko:K16554	ko05111,map05111	-	-	-	ko00000,ko00001,ko02000	8.A.3.1	-	-	AAA_31,CbiA,GNVR,ParA,Wzz
k59_1680575_1	1192034.CAP_2018	2.3e-49	174.0	COG2159@1|root,COG2159@2|Bacteria,1N0C7@1224|Proteobacteria,437UX@68525|delta/epsilon subdivisions,2X34D@28221|Deltaproteobacteria,2YU7H@29|Myxococcales	28221|Deltaproteobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
k59_1624581_2	402777.KB235904_gene3449	4.93e-07	54.7	COG0438@1|root,COG1216@1|root,COG0438@2|Bacteria,COG1216@2|Bacteria,1G2A7@1117|Cyanobacteria,1H9SV@1150|Oscillatoriales	1117|Cyanobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1,Glycos_transf_2
k59_1736095_1	81985.XP_006287548.1	1.61e-30	120.0	COG0334@1|root,KOG2250@2759|Eukaryota,37Q3I@33090|Viridiplantae,3GC9F@35493|Streptophyta,3HRES@3699|Brassicales	35493|Streptophyta	E	Belongs to the Glu Leu Phe Val dehydrogenases family	-	GO:0000166,GO:0003674,GO:0003824,GO:0004352,GO:0004353,GO:0005488,GO:0005507,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005773,GO:0005774,GO:0006950,GO:0006970,GO:0006995,GO:0007154,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009267,GO:0009268,GO:0009605,GO:0009628,GO:0009651,GO:0009987,GO:0009991,GO:0010035,GO:0010038,GO:0010446,GO:0016020,GO:0016491,GO:0016638,GO:0016639,GO:0017076,GO:0030554,GO:0031090,GO:0031667,GO:0031668,GO:0031669,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0035639,GO:0036094,GO:0042221,GO:0042594,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043562,GO:0044422,GO:0044424,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0046686,GO:0046872,GO:0046914,GO:0050896,GO:0050897,GO:0051716,GO:0055114,GO:0071496,GO:0097159,GO:0097367,GO:0098588,GO:0098805,GO:1901265,GO:1901363	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
k59_1736095_2	1484460.JSWG01000001_gene2193	4.18e-24	98.6	COG0560@1|root,COG0560@2|Bacteria,4NIF2@976|Bacteroidetes,1HZ6P@117743|Flavobacteriia	976|Bacteroidetes	E	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
k59_568492_1	589865.DaAHT2_0901	3.78e-88	285.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,42MGK@68525|delta/epsilon subdivisions,2WJQH@28221|Deltaproteobacteria,2MHQD@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Carbamoyl-phosphate synthetase large chain oligomerisation	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_1237246_1	1089552.KI911559_gene1129	2.49e-36	138.0	COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,2TTV2@28211|Alphaproteobacteria,2JP90@204441|Rhodospirillales	204441|Rhodospirillales	S	Zn-dependent protease, contains TPR repeats	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48,TPR_16
k59_1346994_1	1035308.AQYY01000001_gene2064	9.3e-17	80.9	COG1123@1|root,COG4172@2|Bacteria,1UZK8@1239|Firmicutes,2511Z@186801|Clostridia,260WH@186807|Peptococcaceae	186801|Clostridia	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_1346994_2	768704.Desmer_2638	6.66e-31	118.0	COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,24C3R@186801|Clostridia,260CP@186807|Peptococcaceae	186801|Clostridia	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
k59_68385_1	926569.ANT_16440	5.23e-77	251.0	COG2414@1|root,COG2414@2|Bacteria,2G5XP@200795|Chloroflexi	200795|Chloroflexi	C	PFAM aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
k59_1347007_1	1038858.AXBA01000010_gene2714	6.74e-37	142.0	COG3276@1|root,COG3276@2|Bacteria,1MWXH@1224|Proteobacteria,2TUFY@28211|Alphaproteobacteria,3EZ5H@335928|Xanthobacteraceae	28211|Alphaproteobacteria	J	Elongation factor SelB, winged helix	-	-	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3
k59_1402732_1	877414.ATWA01000003_gene360	1.85e-35	130.0	COG0566@1|root,COG0566@2|Bacteria,1TP9G@1239|Firmicutes,247SC@186801|Clostridia,267IS@186813|unclassified Clostridiales	186801|Clostridia	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	yacO	-	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
k59_346087_1	1502851.FG93_03479	1.13e-106	313.0	COG2894@1|root,COG2894@2|Bacteria,1MUEU@1224|Proteobacteria,2TSAG@28211|Alphaproteobacteria,3JTQF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	D	Cellulose biosynthesis protein BcsQ	minD	-	-	ko:K03609	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31,CbiA
k59_624115_1	1117647.M5M_13590	1.46e-71	237.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,1RPDE@1236|Gammaproteobacteria,1J8XH@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	COG3119 Arylsulfatase A and related enzymes	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_1402739_1	1521187.JPIM01000056_gene2607	3.58e-65	217.0	COG1164@1|root,COG1164@2|Bacteria,2G5UV@200795|Chloroflexi,376XT@32061|Chloroflexia	32061|Chloroflexia	E	PFAM peptidase M3A and M3B, thimet oligopeptidase F	-	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
k59_346093_1	1392502.JNIO01000002_gene602	1.05e-27	114.0	COG0577@1|root,COG0577@2|Bacteria,1TPUU@1239|Firmicutes,4H2H6@909932|Negativicutes	909932|Negativicutes	V	Efflux ABC transporter permease protein	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_680533_1	1528106.JRJE01000031_gene3290	5.75e-73	238.0	COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2TQP0@28211|Alphaproteobacteria,2JPA1@204441|Rhodospirillales	204441|Rhodospirillales	P	COG1123 ATPase components of various ABC-type transport systems, contain duplicated ATPase	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_682871_1	926569.ANT_18230	5.49e-101	311.0	COG0649@1|root,COG0852@1|root,COG0649@2|Bacteria,COG0852@2|Bacteria,2G5JF@200795|Chloroflexi	200795|Chloroflexi	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	-	1.6.5.3	ko:K00333,ko:K13378	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa,Complex1_49kDa
k59_1571670_2	945713.IALB_1991	4.84e-23	96.7	COG0727@1|root,COG0727@2|Bacteria	2|Bacteria	S	metal cluster binding	-	-	-	-	-	-	-	-	-	-	-	-	CxxCxxCC
k59_1626669_1	118173.KB235914_gene4160	1.05e-44	163.0	COG0025@1|root,COG0569@1|root,COG0025@2|Bacteria,COG0569@2|Bacteria,1G21K@1117|Cyanobacteria,1H9AE@1150|Oscillatoriales	1117|Cyanobacteria	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	nhaP	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,TrkA_N
k59_1182561_2	1121360.AUAQ01000012_gene1800	5e-36	131.0	COG0190@1|root,COG0190@2|Bacteria,2GJZS@201174|Actinobacteria,22KKE@1653|Corynebacteriaceae	201174|Actinobacteria	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0040007,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
k59_848387_1	1321784.HMPREF1987_01485	6.47e-23	100.0	COG1307@1|root,COG1307@2|Bacteria,1TRM7@1239|Firmicutes,247ST@186801|Clostridia,25T8N@186804|Peptostreptococcaceae	186801|Clostridia	S	Uncharacterised protein, DegV family COG1307	-	-	-	-	-	-	-	-	-	-	-	-	DegV
k59_682905_2	926569.ANT_29550	1.71e-14	75.1	COG0631@1|root,COG0631@2|Bacteria,2G6R4@200795|Chloroflexi	200795|Chloroflexi	T	SMART protein phosphatase 2C domain protein	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
k59_1626696_2	926550.CLDAP_18190	2.74e-20	85.9	COG1146@1|root,COG1146@2|Bacteria,2G75G@200795|Chloroflexi	200795|Chloroflexi	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_4
k59_237706_1	1111454.HMPREF1250_2034	3.08e-99	303.0	COG0056@1|root,COG0056@2|Bacteria,1TNZ8@1239|Firmicutes,4H2EY@909932|Negativicutes	909932|Negativicutes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N,OSCP
k59_1239512_1	370438.PTH_1020	1.09e-15	78.2	COG0162@1|root,COG0162@2|Bacteria,1TPGN@1239|Firmicutes,247QC@186801|Clostridia,2601M@186807|Peptococcaceae	186801|Clostridia	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
k59_1239512_2	1379270.AUXF01000003_gene3432	1.03e-39	135.0	COG0662@1|root,COG0662@2|Bacteria,1ZTKY@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Mannose-6-phosphate isomerase	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_70537_1	479434.Sthe_3231	4.04e-13	69.3	COG0345@1|root,COG0345@2|Bacteria,2G5QD@200795|Chloroflexi,27Y1C@189775|Thermomicrobia	189775|Thermomicrobia	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
k59_70537_2	926569.ANT_28140	1.53e-26	106.0	COG0192@1|root,COG0192@2|Bacteria,2G5X0@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
k59_515560_1	314230.DSM3645_19538	8.61e-62	208.0	COG0843@1|root,COG0843@2|Bacteria,2IXCQ@203682|Planctomycetes	203682|Planctomycetes	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_1405074_1	95619.PM1_0210830	1.19e-67	221.0	COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,1RMEI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Belongs to the ABC transporter superfamily	yejF	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006857,GO:0008144,GO:0008150,GO:0015399,GO:0015405,GO:0015833,GO:0015893,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0035672,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0042626,GO:0042884,GO:0042886,GO:0042891,GO:0043167,GO:0043168,GO:0043492,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K13896	ko02010,map02010	M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.21,3.A.1.5.24	-	-	ABC_tran,oligo_HPY
k59_682932_1	234267.Acid_0808	4.69e-42	151.0	COG3858@1|root,COG3858@2|Bacteria,3Y46G@57723|Acidobacteria	57723|Acidobacteria	S	hydrolase, family 18	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_18
k59_237734_1	349124.Hhal_1477	1.92e-09	58.9	COG0576@1|root,COG0576@2|Bacteria,1RH8T@1224|Proteobacteria,1S5W5@1236|Gammaproteobacteria,1WY2F@135613|Chromatiales	135613|Chromatiales	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
k59_237734_2	1410620.SHLA_24c000090	1.77e-68	224.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,2TR5H@28211|Alphaproteobacteria,4B8XC@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
k59_1016208_1	1313172.YM304_11760	7.47e-60	197.0	COG4143@1|root,COG4143@2|Bacteria,2GMWD@201174|Actinobacteria	201174|Actinobacteria	H	ABC transporter, periplasmic binding protein, thiB subfamily	thiB	-	-	ko:K02064	ko02010,map02010	M00191	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.19	-	-	SBP_bac_6
k59_1682827_1	293826.Amet_2314	8.65e-78	254.0	COG0495@1|root,COG0495@2|Bacteria,1TP0Y@1239|Firmicutes,2484Y@186801|Clostridia,36DKN@31979|Clostridiaceae	186801|Clostridia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
k59_1293525_1	518766.Rmar_1896	1.2e-57	197.0	COG1164@1|root,COG1164@2|Bacteria,4NFYH@976|Bacteroidetes,1FIWW@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	E	Oligopeptidase F	pepF	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
k59_1182625_1	1089552.KI911559_gene2482	5.54e-93	284.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,2TS63@28211|Alphaproteobacteria,2JPW2@204441|Rhodospirillales	204441|Rhodospirillales	C	Belongs to the citrate synthase family	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
k59_125691_1	1038866.KB902806_gene2451	1.52e-59	195.0	COG2072@1|root,COG2072@2|Bacteria,1MWPJ@1224|Proteobacteria,2TSQA@28211|Alphaproteobacteria,3JT1R@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	ko:K07222	-	-	-	-	ko00000	-	-	-	Pyr_redox_3
k59_125691_2	1038866.KB902806_gene2452	3.93e-36	127.0	COG1765@1|root,COG1765@2|Bacteria,1RBJN@1224|Proteobacteria,2VF54@28211|Alphaproteobacteria,3K6E6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
k59_1738414_1	32057.KB217478_gene7481	2.95e-23	99.0	COG0469@1|root,COG0469@2|Bacteria,1G1IY@1117|Cyanobacteria,1HM87@1161|Nostocales	1117|Cyanobacteria	G	Belongs to the pyruvate kinase family	pykF	GO:0003674,GO:0003824,GO:0004743,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PEP-utilizers,PK,PK_C
k59_1182646_1	1299327.I546_4212	4.44e-06	53.9	COG1055@1|root,COG1055@2|Bacteria,2GMQJ@201174|Actinobacteria,236EE@1762|Mycobacteriaceae	201174|Actinobacteria	P	transport of arsenical compounds across the membrane (export) arsenic resistance by an export mechanism. responsible for the translocation of the substrate across the membrane	arsB1	-	-	ko:K03893	-	-	-	-	ko00000,ko02000	2.A.45.1,3.A.4.1	-	-	ArsB,CitMHS
k59_515621_1	1473546.CH76_08915	1.98e-33	132.0	COG0624@1|root,COG0624@2|Bacteria,1TP2D@1239|Firmicutes,4HB9G@91061|Bacilli,3IX6C@400634|Lysinibacillus	91061|Bacilli	E	Peptidase M20	dapE	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
k59_738219_1	351607.Acel_0150	9.09e-19	89.7	COG1575@1|root,COG1575@2|Bacteria,2GJBS@201174|Actinobacteria,4ESBC@85013|Frankiales	201174|Actinobacteria	H	Belongs to the MenA family. Type 1 subfamily	menA	GO:0003674,GO:0003824,GO:0004659,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006766,GO:0006775,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009233,GO:0009234,GO:0009987,GO:0016740,GO:0016765,GO:0032194,GO:0042180,GO:0042181,GO:0042362,GO:0042371,GO:0042373,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
k59_70602_1	448385.sce1960	0.000737	43.9	COG2227@1|root,COG2227@2|Bacteria,1PG06@1224|Proteobacteria,43EA8@68525|delta/epsilon subdivisions,2WRYS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Methyltransferase domain	-	-	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	-
k59_348264_1	234267.Acid_7550	1.78e-34	122.0	COG1695@1|root,COG1695@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	-	-	-	-	-	-	-	-	-	PadR
k59_1460961_1	401526.TcarDRAFT_1910	5.2e-25	108.0	COG4753@1|root,COG4963@1|root,COG4753@2|Bacteria,COG4963@2|Bacteria,1UF2S@1239|Firmicutes,4H306@909932|Negativicutes	909932|Negativicutes	KTU	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_31,Response_reg
k59_1405161_2	1380390.JIAT01000010_gene4305	2.24e-27	107.0	COG0558@1|root,COG0558@2|Bacteria,2GK5D@201174|Actinobacteria,4CQIK@84995|Rubrobacteria	84995|Rubrobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
k59_348279_1	1379270.AUXF01000003_gene3822	1.1e-87	286.0	COG0243@1|root,COG0437@1|root,COG0243@2|Bacteria,COG0437@2|Bacteria,1ZSRY@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	4Fe-4S dicluster domain	-	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal
k59_1405169_1	903818.KI912268_gene806	5.58e-83	275.0	COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,3Y2JQ@57723|Acidobacteria	57723|Acidobacteria	E	glutamate synthase alpha subunit	-	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_585173_1	420324.KI911999_gene8064	2.27e-60	206.0	28JZZ@1|root,2Z9PZ@2|Bacteria,1N3C6@1224|Proteobacteria,2TSCX@28211|Alphaproteobacteria,1JTZB@119045|Methylobacteriaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1475937_1	671143.DAMO_2996	2.31e-85	273.0	COG1032@1|root,COG1032@2|Bacteria,2NQU0@2323|unclassified Bacteria	2|Bacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
k59_140490_1	671143.DAMO_2398	3.73e-21	87.4	2CP7W@1|root,32MRP@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_140490_2	673860.AciM339_0447	1.36e-06	49.7	COG2426@1|root,arCOG01330@2157|Archaea,2XZ2Y@28890|Euryarchaeota,3F3AR@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Putative small multi-drug export protein	-	-	-	-	-	-	-	-	-	-	-	-	Sm_multidrug_ex
k59_1640906_1	580340.Tlie_0313	7.33e-10	65.1	COG4907@1|root,COG4907@2|Bacteria,3TA8F@508458|Synergistetes	508458|Synergistetes	S	membrane protein (DUF2207)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2207
k59_363031_1	234267.Acid_5940	4.89e-30	124.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria	57723|Acidobacteria	KLTU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
k59_976138_1	1385935.N836_03240	7.52e-11	62.8	2EM9G@1|root,33EYK@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_976138_2	670487.Ocepr_0607	2.07e-46	168.0	COG0366@1|root,COG0366@2|Bacteria,1WIC6@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	Alpha-amylase domain	-	-	3.2.1.133,3.2.1.135,3.2.1.54	ko:K01208	ko00500,ko01100,map00500,map01100	-	R02112,R03122,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	AMPK1_CBM,Alpha-amylase
k59_640499_1	411467.BACCAP_00109	5.31e-41	149.0	COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,24888@186801|Clostridia,267UR@186813|unclassified Clostridiales	186801|Clostridia	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
k59_921645_1	909663.KI867150_gene433	2.65e-56	191.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WIWE@28221|Deltaproteobacteria,2MQB7@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	Belongs to the peptidase S1C family	degP-2	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
k59_1698918_1	2340.JV46_07710	9.73e-35	136.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1J5F8@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_251919_1	1121930.AQXG01000002_gene1962	3.71e-40	148.0	COG0431@1|root,COG1878@1|root,COG0431@2|Bacteria,COG1878@2|Bacteria,4NNMA@976|Bacteroidetes,1IT25@117747|Sphingobacteriia	976|Bacteroidetes	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
k59_1254846_2	1318628.MARLIPOL_12739	2.41e-31	122.0	COG4964@1|root,COG4964@2|Bacteria,1MV8G@1224|Proteobacteria,1RQ4U@1236|Gammaproteobacteria,4683Q@72275|Alteromonadaceae	1236|Gammaproteobacteria	U	Belongs to the GSP D family	cpaC	-	-	ko:K02280	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	BON,Secretin,T2SS-T3SS_pil_N
k59_85552_1	1150626.PHAMO_10200	5.83e-48	167.0	COG2177@1|root,COG2177@2|Bacteria,1MXKQ@1224|Proteobacteria,2TSNT@28211|Alphaproteobacteria,2JS4N@204441|Rhodospirillales	204441|Rhodospirillales	D	Cell division protein	-	-	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	-
k59_29971_1	926569.ANT_09370	2.18e-66	218.0	COG0739@1|root,COG1388@1|root,COG0739@2|Bacteria,COG1388@2|Bacteria,2G6Q7@200795|Chloroflexi	200795|Chloroflexi	M	Peptidoglycan-binding LysM	-	-	-	-	-	-	-	-	-	-	-	-	LysM,Peptidase_M23,SH3_3
k59_1254847_1	861299.J421_1097	3.1e-46	155.0	COG2318@1|root,COG2318@2|Bacteria,1ZV4X@142182|Gemmatimonadetes	2|Bacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB,DinB_2
k59_29975_1	543728.Vapar_0190	1.51e-25	110.0	COG1529@1|root,COG2010@1|root,COG1529@2|Bacteria,COG2010@2|Bacteria,1MV6D@1224|Proteobacteria,2WHBT@28216|Betaproteobacteria,4AATP@80864|Comamonadaceae	28216|Betaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.17.2.1	ko:K18030	ko00760,ko01120,map00760,map01120	M00622	R09473	RC00589	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C2,Cytochrom_C,Cytochrome_CBB3
k59_29982_1	1366050.N234_28630	6e-36	135.0	COG5476@1|root,COG5476@2|Bacteria,1NS9S@1224|Proteobacteria,2W0JP@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Involved in peptidolytic degradation of cyclic heptapeptide hepatotoxin microcystin (MC)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1485,MlrC_C
k59_29982_2	391593.RCCS2_10430	3.84e-10	60.8	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TQQH@28211|Alphaproteobacteria,2P2J1@2433|Roseobacter	28211|Alphaproteobacteria	E	COG0747 ABC-type dipeptide transport system, periplasmic component	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_1419689_1	1122605.KB893637_gene3311	6.53e-44	162.0	COG3250@1|root,COG3250@2|Bacteria,4NGZH@976|Bacteroidetes,1IWQR@117747|Sphingobacteriia	976|Bacteroidetes	G	alpha-L-rhamnosidase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_106
k59_1752490_1	1123060.JONP01000001_gene1304	1.26e-29	116.0	COG4589@1|root,COG4589@2|Bacteria,1MX58@1224|Proteobacteria,2TT9I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Phosphatidate cytidylyltransferase	cdsA2	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
k59_363099_2	296591.Bpro_1648	2.58e-101	294.0	COG0346@1|root,COG0346@2|Bacteria,1RABI@1224|Proteobacteria,2VVN9@28216|Betaproteobacteria,4AI4B@80864|Comamonadaceae	28216|Betaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase_4
k59_1086691_1	388399.SSE37_02345	3.84e-84	260.0	COG3181@1|root,COG3181@2|Bacteria,1MWVK@1224|Proteobacteria,2TXW7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_585263_1	644966.Tmar_1596	3.27e-21	95.1	COG0843@1|root,COG0843@2|Bacteria,1TP2U@1239|Firmicutes,24YCV@186801|Clostridia	186801|Clostridia	C	Cytochrome C and Quinol oxidase polypeptide I	-	-	1.10.3.12,1.9.3.1	ko:K02274,ko:K02827	ko00190,ko01100,map00190,map01100	M00155,M00416	R00081,R09492	RC00016,RC00819	ko00000,ko00001,ko00002,ko01000	3.D.4.1,3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_585263_2	926569.ANT_05310	1.29e-24	104.0	COG1622@1|root,COG2010@1|root,COG2197@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,COG2197@2|Bacteria,2G6C0@200795|Chloroflexi	200795|Chloroflexi	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrom_C
k59_1640949_1	330214.NIDE0061	3.29e-28	105.0	COG0640@1|root,COG0640@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20,HTH_5
k59_1586830_1	1036674.A28LD_0085	1.56e-35	137.0	COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,1RNPZ@1236|Gammaproteobacteria,2QFHQ@267893|Idiomarinaceae	1236|Gammaproteobacteria	L	May be involved in recombinational repair of damaged DNA	recN	GO:0000724,GO:0000725,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:1901360	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SMC_N
k59_1419707_1	867845.KI911784_gene1154	2.1e-26	105.0	COG1595@1|root,COG1595@2|Bacteria,2G6MG@200795|Chloroflexi,375K5@32061|Chloroflexia	32061|Chloroflexia	K	PFAM sigma-70 region 2 domain protein	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_308579_1	1131266.ARWQ01000029_gene980	3.37e-18	89.0	COG4257@1|root,arCOG06267@1|root,arCOG03564@2157|Archaea,arCOG06267@2157|Archaea,41S5S@651137|Thaumarchaeota	651137|Thaumarchaeota	V	resistance protein	-	-	-	ko:K14166	-	-	-	-	ko00000,ko02000	-	-	-	CopC,CopD
k59_698056_1	113395.AXAI01000026_gene1887	1.55e-52	187.0	COG4191@1|root,COG5002@1|root,COG4191@2|Bacteria,COG5002@2|Bacteria,1RCM9@1224|Proteobacteria,2TTJ0@28211|Alphaproteobacteria,3K6MV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Cache domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,PAS_7,dCache_1
k59_1032715_1	1304874.JAFY01000002_gene335	3.25e-60	205.0	COG2943@1|root,COG2943@2|Bacteria,3TAHN@508458|Synergistetes	508458|Synergistetes	M	Glycosyl transferase family 21	-	-	-	ko:K03669	-	-	-	-	ko00000,ko01000,ko01003,ko02000	4.D.3.1.1	GT2	-	Glyco_trans_2_3,Glycos_transf_2
k59_251976_1	1051632.TPY_3150	1.24e-117	352.0	COG3328@1|root,COG3328@2|Bacteria,1TP4C@1239|Firmicutes,248UI@186801|Clostridia	186801|Clostridia	L	PFAM transposase, mutator	-	-	-	ko:K07493	-	-	-	-	ko00000	-	-	-	Transposase_mut
k59_808484_1	926569.ANT_02580	8.13e-10	58.9	COG0530@1|root,COG0530@2|Bacteria,2G7I2@200795|Chloroflexi	200795|Chloroflexi	P	PFAM sodium calcium exchanger membrane region	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
k59_808491_1	1532557.JL37_15960	9.73e-68	219.0	COG4638@1|root,COG4638@2|Bacteria,1N6MJ@1224|Proteobacteria,2VQ87@28216|Betaproteobacteria,3T2ZG@506|Alcaligenaceae	28216|Betaproteobacteria	P	Ring hydroxylating alpha subunit (catalytic domain)	hcaE	-	1.14.12.11,1.14.12.19,1.14.12.3	ko:K03268,ko:K05708	ko00360,ko00361,ko00362,ko00623,ko00625,ko01100,ko01120,ko01220,map00360,map00361,map00362,map00623,map00625,map01100,map01120,map01220	M00545,M00547	R03543,R03559,R05429,R06782,R06783,R06831,R06856,R09151,R09152	RC00098,RC00267,RC00951,RC03011,RC03012,RC03013	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske,Ring_hydroxyl_A
k59_1142887_1	392499.Swit_2067	9.8e-73	227.0	COG1024@1|root,COG1024@2|Bacteria,1R7VW@1224|Proteobacteria,2UP40@28211|Alphaproteobacteria,2K8U4@204457|Sphingomonadales	204457|Sphingomonadales	I	enoyl-CoA hydratase	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
k59_1699083_2	31954.BPSP_1447	2.44e-14	73.9	COG0164@1|root,COG0164@2|Bacteria,2GJFN@201174|Actinobacteria,4CZ1U@85004|Bifidobacteriales	201174|Actinobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
k59_1032777_1	47839.CCAU010000004_gene892	2.09e-20	90.9	COG2114@1|root,COG2114@2|Bacteria,2IC2V@201174|Actinobacteria,237XA@1762|Mycobacteriaceae	201174|Actinobacteria	T	guanylate cyclase catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc
k59_1311694_1	1121946.AUAX01000017_gene5107	2.03e-53	180.0	COG2267@1|root,COG2267@2|Bacteria,2I9JC@201174|Actinobacteria,4DC8R@85008|Micromonosporales	201174|Actinobacteria	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
k59_1701023_1	1173029.JH980292_gene4046	7.6e-92	274.0	COG4577@1|root,COG4577@2|Bacteria,1G0GA@1117|Cyanobacteria,1H73J@1150|Oscillatoriales	1117|Cyanobacteria	CQ	PFAM BMC domain	-	-	-	-	-	-	-	-	-	-	-	-	BMC
k59_478737_1	926550.CLDAP_34690	3.52e-95	290.0	COG0075@1|root,COG0075@2|Bacteria,2G5P3@200795|Chloroflexi	200795|Chloroflexi	E	PFAM aminotransferase class V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
k59_1478019_1	1163617.SCD_n02571	1.17e-56	193.0	COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,2VH1I@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
k59_31803_1	1120949.KB903294_gene3893	1.7e-78	239.0	2DBMA@1|root,2Z9Y3@2|Bacteria,2I9ER@201174|Actinobacteria,4DEM5@85008|Micromonosporales	201174|Actinobacteria	S	Domain of unknown function (DUF4389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4389
k59_1532725_1	338963.Pcar_2149	1.81e-75	243.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIPP@28221|Deltaproteobacteria,43TCZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	NU	General secretory system II, protein E domain protein	pilB	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N,cNMP_binding
k59_310766_1	1423815.BACR01000039_gene1925	6.69e-20	88.6	COG2738@1|root,COG2738@2|Bacteria,1TPD3@1239|Firmicutes,4HB8Z@91061|Bacilli,3F4E2@33958|Lactobacillaceae	91061|Bacilli	S	Putative neutral zinc metallopeptidase	yugP	-	-	ko:K06973	-	-	-	-	ko00000	-	-	-	Zn_peptidase_2
k59_253804_1	1121344.JHZO01000005_gene97	1.5e-84	267.0	COG1217@1|root,COG1217@2|Bacteria,1TQ5Y@1239|Firmicutes,248EB@186801|Clostridia,3WGEU@541000|Ruminococcaceae	186801|Clostridia	T	GTP-binding protein TypA	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2
k59_1532729_1	1122239.AULS01000003_gene2719	2.44e-05	46.2	COG4974@1|root,COG4974@2|Bacteria,2GNDP@201174|Actinobacteria,4FMIB@85023|Microbacteriaceae	201174|Actinobacteria	L	Phage integrase, N-terminal SAM-like domain	xerD	GO:0008150,GO:0040007	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_1532729_2	999423.HMPREF9161_00296	1.24e-29	119.0	COG1206@1|root,COG1206@2|Bacteria,1TP67@1239|Firmicutes,4H39S@909932|Negativicutes	909932|Negativicutes	J	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs	trmFO	-	2.1.1.74	ko:K04094	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	GIDA
k59_754599_1	926569.ANT_29790	1.2e-47	161.0	COG0739@1|root,COG0739@2|Bacteria	2|Bacteria	M	heme binding	-	-	-	ko:K21472	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
k59_365142_1	391612.CY0110_06344	5.4e-18	78.6	COG1917@1|root,COG1917@2|Bacteria,1G6ED@1117|Cyanobacteria	1117|Cyanobacteria	S	protein contains double-stranded beta-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_365142_2	234267.Acid_3302	2.88e-34	119.0	COG1942@1|root,COG1942@2|Bacteria	2|Bacteria	S	isomerase activity	-	-	5.3.2.6	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	M00569	R03966,R05389	RC01040,RC01355	ko00000,ko00001,ko00002,ko01000	-	-	-	Tautomerase
k59_365142_3	436229.JOEH01000051_gene6284	8.18e-08	52.8	COG1063@1|root,COG1063@2|Bacteria,2GISW@201174|Actinobacteria,2NKQQ@228398|Streptacidiphilus	201174|Actinobacteria	E	Alcohol dehydrogenase GroES-like domain	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
k59_978382_1	1121898.Q766_15630	6.68e-08	54.3	COG3118@1|root,COG3118@2|Bacteria,4NSE6@976|Bacteroidetes,1I47G@117743|Flavobacteriia,2NWTE@237|Flavobacterium	976|Bacteroidetes	O	general stress protein	ytxJ	-	-	-	-	-	-	-	-	-	-	-	DUF2847
k59_87437_1	472759.Nhal_2814	4.85e-27	105.0	COG0164@1|root,COG0164@2|Bacteria,1RA65@1224|Proteobacteria,1RQ4B@1236|Gammaproteobacteria,1WYG2@135613|Chromatiales	135613|Chromatiales	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	-	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
k59_87437_2	573370.DMR_34640	7.26e-24	95.9	COG0792@1|root,COG0792@2|Bacteria,1N6VN@1224|Proteobacteria,42VES@68525|delta/epsilon subdivisions,2WRSC@28221|Deltaproteobacteria,2MCFG@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	Belongs to the UPF0102 family	-	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
k59_1588845_1	631362.Thi970DRAFT_03646	8.16e-95	285.0	COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,1RP45@1236|Gammaproteobacteria,1WXIF@135613|Chromatiales	135613|Chromatiales	S	associated with various cellular activities	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
k59_1311793_1	1459636.NTE_02745	7.81e-90	267.0	COG0049@1|root,arCOG04254@2157|Archaea,41S6U@651137|Thaumarchaeota	651137|Thaumarchaeota	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center	rps7	-	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
k59_31863_2	644966.Tmar_0137	1.98e-30	121.0	COG2986@1|root,COG2986@2|Bacteria,1TPCW@1239|Firmicutes,247XP@186801|Clostridia,3WCEP@538999|Clostridiales incertae sedis	186801|Clostridia	E	Aromatic amino acid lyase	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
k59_532360_1	926569.ANT_25420	2.97e-93	284.0	COG0148@1|root,COG0148@2|Bacteria,2G5VB@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
k59_365196_1	324602.Caur_2513	6.65e-94	285.0	COG3508@1|root,COG3508@2|Bacteria,2G7RN@200795|Chloroflexi,3766I@32061|Chloroflexia	32061|Chloroflexia	Q	PFAM homogentisate 12-dioxygenase	-	-	1.13.11.5	ko:K00451	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R02519	RC00737	ko00000,ko00001,ko00002,ko01000	-	-	-	HgmA
k59_1366742_2	1379270.AUXF01000002_gene1585	6.44e-34	130.0	COG0515@1|root,COG0515@2|Bacteria,1ZUMJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
k59_31876_1	83406.HDN1F_07400	4.94e-103	315.0	COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,1RMJB@1236|Gammaproteobacteria,1J5FD@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	GTP-binding protein TypA	typA	GO:0000027,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006996,GO:0008150,GO:0009266,GO:0009408,GO:0009409,GO:0009628,GO:0009987,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071826,GO:0071840	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
k59_253882_1	1148.1001271	1.88e-62	213.0	COG0305@1|root,COG1372@1|root,COG0305@2|Bacteria,COG1372@2|Bacteria,1G0R8@1117|Cyanobacteria,1H50M@1142|Synechocystis	1117|Cyanobacteria	L	Participates in initiation and elongation during chromosome replication	dnaB	GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0032392,GO:0032508,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C,Intein_splicing,LAGLIDADG_3
k59_864734_1	743525.TSC_c09900	8.45e-17	84.0	COG0466@1|root,COG0466@2|Bacteria,1WISX@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon2	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_864734_2	1229172.JQFA01000002_gene3097	2.33e-05	45.4	COG0071@1|root,COG0071@2|Bacteria,1G5PX@1117|Cyanobacteria,1HAZK@1150|Oscillatoriales	1117|Cyanobacteria	O	Belongs to the small heat shock protein (HSP20) family	hspA	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
k59_478848_1	313606.M23134_03166	7.67e-88	290.0	COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,4NFHX@976|Bacteroidetes,47KS7@768503|Cytophagia	976|Bacteroidetes	EI	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly	icmF	-	5.4.99.13	ko:K11942	-	-	-	-	ko00000,ko01000	-	-	-	ArgK,B12-binding,MM_CoA_mutase
k59_810623_1	1089553.Tph_c08880	7.73e-15	72.0	COG0139@1|root,COG0140@1|root,COG0139@2|Bacteria,COG0140@2|Bacteria,1UYNA@1239|Firmicutes,247RS@186801|Clostridia,42F6A@68295|Thermoanaerobacterales	186801|Clostridia	E	Histidine biosynthesis bifunctional protein hisIE	hisI	-	3.5.4.19,3.6.1.31	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS05760	His_biosynth,PRA-CH,PRA-PH
k59_810623_2	795359.TOPB45_0492	3.77e-29	110.0	COG0107@1|root,COG0107@2|Bacteria,2GGYN@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	-	-	ko:K01663,ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase,His_biosynth
k59_864748_1	1449049.JONW01000009_gene4391	1.35e-15	79.3	2DWE0@1|root,33ZVR@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DoxX
k59_923881_1	247634.GPB2148_2171	1.78e-22	102.0	COG4773@1|root,COG4773@2|Bacteria,1QTXJ@1224|Proteobacteria,1T2K9@1236|Gammaproteobacteria,1JC13@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	COG1629 Outer membrane receptor proteins, mostly Fe transport	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k59_1163405_1	765420.OSCT_2041	5.14e-54	182.0	COG0438@1|root,COG0438@2|Bacteria,2G84C@200795|Chloroflexi,375HH@32061|Chloroflexia	32061|Chloroflexia	M	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1,Methyltransf_11
k59_213145_1	997346.HMPREF9374_2545	7.53e-15	79.7	COG0582@1|root,COG0582@2|Bacteria,1TTJI@1239|Firmicutes,4HDG6@91061|Bacilli,27C43@186824|Thermoactinomycetaceae	91061|Bacilli	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Arm-DNA-bind_4,Phage_int_SAM_3,Phage_int_SAM_5,Phage_integrase
k59_1548324_2	1380394.JADL01000007_gene4632	1.43e-86	259.0	COG5553@1|root,COG5553@2|Bacteria,1RD6A@1224|Proteobacteria,2U7HF@28211|Alphaproteobacteria,2JVV3@204441|Rhodospirillales	204441|Rhodospirillales	S	of the double-stranded beta helix	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1718205_2	926569.ANT_23430	3.8e-80	249.0	COG1181@1|root,COG1181@2|Bacteria,2G5RS@200795|Chloroflexi	200795|Chloroflexi	F	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
k59_1439324_1	671143.DAMO_1166	5.39e-37	132.0	COG1622@1|root,COG1622@2|Bacteria,2NNSH@2323|unclassified Bacteria	2|Bacteria	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	coxM	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009319,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034641,GO:0042773,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0055086,GO:0055114,GO:0070069,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrom_C
k59_1718213_2	1167006.UWK_02376	3.63e-13	71.2	COG0685@1|root,COG0685@2|Bacteria,1NB3G@1224|Proteobacteria,42P1W@68525|delta/epsilon subdivisions,2WKDD@28221|Deltaproteobacteria,2MJ0X@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Methylene-tetrahydrofolate reductase C terminal	-	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR,MTHFR_C
k59_1163440_1	1168289.AJKI01000002_gene2704	1.56e-19	95.1	28JBD@1|root,2Z964@2|Bacteria,4P5YC@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1439337_2	632292.Calhy_0101	2.1e-24	100.0	COG1801@1|root,COG1801@2|Bacteria,1TPX4@1239|Firmicutes,24IAX@186801|Clostridia,42GB4@68295|Thermoanaerobacterales	186801|Clostridia	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
k59_1163446_1	1869.MB27_39850	6.01e-38	145.0	COG3903@1|root,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,4DBPZ@85008|Micromonosporales	201174|Actinobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc
k59_1660221_1	485916.Dtox_3166	2.46e-07	52.8	COG0136@1|root,COG0136@2|Bacteria,1TPC6@1239|Firmicutes,248ZR@186801|Clostridia,260A6@186807|Peptococcaceae	186801|Clostridia	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
k59_1660221_2	1123023.JIAI01000010_gene8702	9.34e-05	48.1	COG0527@1|root,COG0527@2|Bacteria,2GN0G@201174|Actinobacteria,4DYQ8@85010|Pseudonocardiales	201174|Actinobacteria	E	Belongs to the aspartokinase family	-	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
k59_1385265_2	1219084.AP014508_gene1733	6.2e-14	75.9	COG4796@1|root,COG4796@2|Bacteria,2GC9B@200918|Thermotogae	200918|Thermotogae	U	Belongs to the GSP D family	-	-	-	-	-	-	-	-	-	-	-	-	Secretin
k59_1051747_1	403833.Pmob_1577	3.55e-49	170.0	COG1173@1|root,COG1173@2|Bacteria,2GCHA@200918|Thermotogae	200918|Thermotogae	EP	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
k59_550835_1	1082933.MEA186_19907	5.51e-89	272.0	COG0683@1|root,COG0683@2|Bacteria,1MUZU@1224|Proteobacteria,2TS7Z@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	ABC-type branched-chain amino acid transport	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_5,Peripla_BP_6
k59_1278437_1	1283287.KB822576_gene3524	1.29e-38	138.0	COG0491@1|root,COG0491@2|Bacteria,2GJU0@201174|Actinobacteria,4DNMS@85009|Propionibacteriales	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
k59_886330_2	160799.PBOR_29830	2.03e-16	80.5	COG0778@1|root,COG0778@2|Bacteria,1V2G8@1239|Firmicutes,4HGR2@91061|Bacilli,26U6J@186822|Paenibacillaceae	91061|Bacilli	C	FMN reductase	-	-	1.5.1.39	ko:K19286	ko00740,ko01100,map00740,map01100	-	R05705,R05706	RC00126	ko00000,ko00001,ko01000	-	-	-	Nitroreductase
k59_772572_1	990285.RGCCGE502_07566	2.3e-63	199.0	COG0200@1|root,COG0200@2|Bacteria,1RDC8@1224|Proteobacteria,2U79D@28211|Alphaproteobacteria,4BAAP@82115|Rhizobiaceae	28211|Alphaproteobacteria	J	Binds to the 23S rRNA	rplO	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
k59_772572_2	1287276.X752_15745	1.6e-31	120.0	COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,2TQMT@28211|Alphaproteobacteria,43H7P@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
k59_440321_1	926569.ANT_29410	1.85e-49	168.0	COG2309@1|root,COG2309@2|Bacteria,2G62B@200795|Chloroflexi	200795|Chloroflexi	E	peptidase M29 aminopeptidase II	-	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
k59_440321_2	243164.DET0911	3.52e-12	65.5	COG2309@1|root,COG2309@2|Bacteria,2G5TH@200795|Chloroflexi,34CT4@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Thermophilic metalloprotease (M29)	-	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
k59_1333168_1	1122137.AQXF01000003_gene1948	6e-50	177.0	COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,2TRI9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	exporters of the RND superfamily	MA20_16090	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
k59_886361_2	269797.Mbar_A3432	2.73e-57	191.0	COG0484@1|root,arCOG02846@2157|Archaea,2XV5D@28890|Euryarchaeota,2N95Q@224756|Methanomicrobia	224756|Methanomicrobia	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
k59_944143_1	926569.ANT_18490	4.42e-43	147.0	COG0785@1|root,COG0785@2|Bacteria,2G6V3@200795|Chloroflexi	200795|Chloroflexi	O	PFAM cytochrome c biogenesis protein, transmembrane region	ccdA	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	DsbD
k59_944143_2	926569.ANT_18500	8.18e-13	68.2	COG1376@1|root,COG1376@2|Bacteria	2|Bacteria	D	ErfK ybiS ycfS ynhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF5011,YkuD
k59_1608166_1	645512.GCWU000246_01691	5e-46	168.0	COG0568@1|root,COG0568@2|Bacteria,3TACS@508458|Synergistetes	508458|Synergistetes	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_1108405_1	1121430.JMLG01000029_gene1492	1.24e-28	116.0	COG3547@1|root,COG3547@2|Bacteria,1TRSB@1239|Firmicutes,249AC@186801|Clostridia,261BQ@186807|Peptococcaceae	186801|Clostridia	L	transposase IS116 IS110 IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_550882_1	502025.Hoch_3633	1.87e-20	89.7	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1MU9U@1224|Proteobacteria,42N86@68525|delta/epsilon subdivisions,2WIV4@28221|Deltaproteobacteria,2YTUK@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.5.1	ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
k59_550882_2	1116472.MGMO_35c00160	9.88e-28	105.0	COG3795@1|root,COG3795@2|Bacteria,1RK95@1224|Proteobacteria,1S6H7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
k59_550882_3	710111.FraQA3DRAFT_2172	9.24e-17	80.5	COG4941@1|root,COG4941@2|Bacteria,2GJ36@201174|Actinobacteria,4ERCP@85013|Frankiales	201174|Actinobacteria	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_1441321_1	926569.ANT_19970	1.75e-77	251.0	COG0556@1|root,COG0556@2|Bacteria,2G5SU@200795|Chloroflexi	200795|Chloroflexi	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
k59_1774238_1	1122135.KB893157_gene440	1.02e-71	225.0	COG2227@1|root,COG2227@2|Bacteria,1MU89@1224|Proteobacteria,2TRIK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway	ubiG	-	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_23
k59_1278539_1	717606.PaecuDRAFT_1224	3.34e-24	101.0	COG0564@1|root,COG0564@2|Bacteria,1TS1T@1239|Firmicutes,4HBRY@91061|Bacilli,26SA6@186822|Paenibacillaceae	91061|Bacilli	J	Responsible for synthesis of pseudouridine from uracil	rluD	-	5.4.99.23,5.4.99.28,5.4.99.29	ko:K06177,ko:K06180	-	-	-	-	ko00000,ko01000,ko03009,ko03016	-	-	-	PseudoU_synth_2
k59_50303_1	1002340.AFCF01000056_gene1983	1.11e-14	78.2	28KF5@1|root,2ZA1D@2|Bacteria,1NFS6@1224|Proteobacteria,2UXNF@28211|Alphaproteobacteria,34GHJ@302485|Phaeobacter	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1333256_2	1460634.JCM19037_2800	1.43e-11	66.2	COG1595@1|root,COG1595@2|Bacteria,1V4T2@1239|Firmicutes,4HHRP@91061|Bacilli	91061|Bacilli	K	binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription	sigX	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
k59_162386_1	1380394.JADL01000001_gene3041	9.59e-64	209.0	COG0683@1|root,COG0683@2|Bacteria,1MV3Y@1224|Proteobacteria,2TU2B@28211|Alphaproteobacteria,2JQHQ@204441|Rhodospirillales	204441|Rhodospirillales	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_886461_1	1173027.Mic7113_1369	4.27e-51	185.0	COG0457@1|root,COG0457@2|Bacteria,1G8AT@1117|Cyanobacteria,1HCX3@1150|Oscillatoriales	1117|Cyanobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF4071
k59_1218013_1	1150469.RSPPHO_00743	1.39e-125	367.0	COG2189@1|root,COG2189@2|Bacteria,1MX9M@1224|Proteobacteria,2TSW9@28211|Alphaproteobacteria,2JPYW@204441|Rhodospirillales	204441|Rhodospirillales	L	Belongs to the N(4) N(6)-methyltransferase family	ccrM	-	2.1.1.72	ko:K13581	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko02048	-	-	-	N6_N4_Mtase
k59_499353_1	1279019.ARQK01000021_gene401	2.66e-67	228.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,1WX4P@135613|Chromatiales	135613|Chromatiales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_385412_1	1532557.JL37_05285	4.93e-40	147.0	COG1929@1|root,COG1929@2|Bacteria,1MVG9@1224|Proteobacteria,2VK3Q@28216|Betaproteobacteria,3T2YY@506|Alcaligenaceae	28216|Betaproteobacteria	G	Belongs to the glycerate kinase type-1 family	glxK	-	2.7.1.165	ko:K00865	ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130	-	R08572	RC00002,RC00428	ko00000,ko00001,ko01000	-	-	-	Gly_kinase
k59_1278580_1	1333998.M2A_1796	2.89e-61	206.0	COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,2TSTJ@28211|Alphaproteobacteria,4BPS2@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	GO:0002790,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032940,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
k59_1165787_1	2074.JNYD01000024_gene2855	2.94e-61	205.0	COG2072@1|root,COG2072@2|Bacteria,2GK95@201174|Actinobacteria,4DYPV@85010|Pseudonocardiales	201174|Actinobacteria	P	Flavin-binding monooxygenase-like	-	-	-	ko:K07222	-	-	-	-	ko00000	-	-	-	FMO-like,Pyr_redox_3
k59_1165787_2	1121035.AUCH01000004_gene390	2.09e-93	281.0	COG3770@1|root,COG3770@2|Bacteria,1PXYG@1224|Proteobacteria,2VRMN@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Penicillin-insensitive murein endopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M74
k59_772676_1	1379270.AUXF01000002_gene1277	1.98e-52	182.0	COG2382@1|root,COG2382@2|Bacteria,1ZUJ9@142182|Gemmatimonadetes	142182|Gemmatimonadetes	P	esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
k59_944259_2	460265.Mnod_4841	3.09e-15	72.4	COG3829@1|root,COG3829@2|Bacteria,1QVJM@1224|Proteobacteria,2U9MQ@28211|Alphaproteobacteria,1JSRM@119045|Methylobacteriaceae	28211|Alphaproteobacteria	KT	SMART PAS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	PAS,PAS_4
k59_721159_1	518766.Rmar_1482	2.77e-84	277.0	COG1629@1|root,COG4206@1|root,COG1629@2|Bacteria,COG4206@2|Bacteria,4NDXS@976|Bacteroidetes	976|Bacteroidetes	P	TonB-linked outer membrane protein, SusC RagA family	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Plug,STN,TonB_dep_Rec
k59_1608256_1	926569.ANT_10890	1.18e-72	223.0	COG2316@1|root,COG2316@2|Bacteria,2G6T2@200795|Chloroflexi	200795|Chloroflexi	S	TIGRFAM metal dependent phophohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HD
k59_1108513_1	865861.AZSU01000002_gene2695	2.98e-36	137.0	COG1001@1|root,COG1001@2|Bacteria,1TP84@1239|Firmicutes,247KN@186801|Clostridia,36DDA@31979|Clostridiaceae	186801|Clostridia	F	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family	ade	-	3.5.4.2	ko:K01486	ko00230,ko01100,map00230,map01100	-	R01244	RC00477	ko00000,ko00001,ko01000	-	-	-	Adenine_deam_C,Amidohydro_1
k59_1333326_1	926569.ANT_00380	4.79e-49	166.0	2ANS9@1|root,31DS7@2|Bacteria,2G7CA@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_944281_1	204669.Acid345_3107	1.7e-05	48.9	COG0440@1|root,COG0440@2|Bacteria,3Y580@57723|Acidobacteria,2JJSH@204432|Acidobacteriia	204432|Acidobacteriia	E	Acetolactate synthase, small subunit	-	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ALS_ss_C
k59_162438_1	926569.ANT_10180	2e-05	44.7	COG0096@1|root,COG0096@2|Bacteria,2G6XS@200795|Chloroflexi	200795|Chloroflexi	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
k59_162438_2	290397.Adeh_1931	8.75e-31	115.0	COG0097@1|root,COG0097@2|Bacteria,1R9YZ@1224|Proteobacteria,42NSE@68525|delta/epsilon subdivisions,2WN9B@28221|Deltaproteobacteria,2YV6Z@29|Myxococcales	28221|Deltaproteobacteria	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
k59_1441423_1	1214101.BN159_6901	3.79e-05	45.4	COG1073@1|root,COG1073@2|Bacteria,2I345@201174|Actinobacteria	201174|Actinobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
k59_1441423_2	309801.trd_A0780	1.12e-28	116.0	COG3848@1|root,COG3848@2|Bacteria,2G8N4@200795|Chloroflexi,27YW7@189775|Thermomicrobia	189775|Thermomicrobia	T	PEP-utilising enzyme, mobile domain	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers
k59_1499201_1	1122951.ATUE01000005_gene1973	1.78e-112	352.0	COG1028@1|root,COG2030@1|root,COG1028@2|Bacteria,COG2030@2|Bacteria,1MXNQ@1224|Proteobacteria,1S0NX@1236|Gammaproteobacteria,3NR1V@468|Moraxellaceae	1236|Gammaproteobacteria	IQ	SCP-2 sterol transfer family	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas,SCP2,adh_short
k59_721199_2	143224.JQMD01000002_gene450	2.15e-56	180.0	COG0454@1|root,COG0454@2|Bacteria,4NPMJ@976|Bacteroidetes,1I2CX@117743|Flavobacteriia	976|Bacteroidetes	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_772716_1	34506.g1592	3.72e-22	94.0	COG0045@1|root,COG0074@1|root,KOG1255@2759|Eukaryota,KOG2799@2759|Eukaryota,38DG1@33154|Opisthokonta,3BA6W@33208|Metazoa,3CRD6@33213|Bilateria,40FSA@6231|Nematoda,1KYNA@119089|Chromadorea	33208|Metazoa	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits	-	-	6.2.1.4,6.2.1.5	ko:K01899	ko00020,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011	R00432,R00727	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
k59_772716_2	331869.BAL199_15703	6.28e-130	379.0	COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,2TRXK@28211|Alphaproteobacteria,4BPP4@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	GO:0003674,GO:0003824,GO:0004774,GO:0004775,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016874,GO:0016877,GO:0016878,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
k59_332501_1	446471.Xcel_2201	9.64e-11	67.4	COG2133@1|root,COG2133@2|Bacteria	2|Bacteria	G	pyrroloquinoline quinone binding	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1278642_1	344747.PM8797T_27954	3.28e-156	460.0	COG4974@1|root,COG4974@2|Bacteria	2|Bacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,PRiA4_ORF3,zf-IS66
k59_886540_2	1192034.CAP_7469	3.03e-23	101.0	COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,42MB1@68525|delta/epsilon subdivisions,2WJ76@28221|Deltaproteobacteria,2YUHH@29|Myxococcales	28221|Deltaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
k59_332508_1	864069.MicloDRAFT_00000710	3.52e-69	219.0	COG0157@1|root,COG0157@2|Bacteria,1MW0C@1224|Proteobacteria,2TS7C@28211|Alphaproteobacteria,1JT1I@119045|Methylobacteriaceae	28211|Alphaproteobacteria	H	Belongs to the NadC ModD family	nadC	-	2.4.2.19	ko:K00767,ko:K03813	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
k59_1662105_1	3218.PP1S240_28V6.1	8.93e-149	426.0	COG0214@1|root,KOG1606@2759|Eukaryota,37KWB@33090|Viridiplantae,3G7GA@35493|Streptophyta	35493|Streptophyta	H	Belongs to the PdxS SNZ family	-	-	4.3.3.6	ko:K06215	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SOR_SNZ
k59_64718_2	990073.ATHU01000001_gene683	3.92e-31	118.0	COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,42NNS@68525|delta/epsilon subdivisions,2YMQW@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
k59_787686_1	88036.EFJ14792	4.07e-44	155.0	COG1218@1|root,KOG1528@2759|Eukaryota,37MDE@33090|Viridiplantae,3G97P@35493|Streptophyta	35493|Streptophyta	FP	SAL1 phosphatase-like	-	-	3.1.3.57,3.1.3.7	ko:K15422	ko00562,ko00920,ko01100,ko01120,ko04070,map00562,map00920,map01100,map01120,map04070	M00131	R00188,R00508,R03393,R03427	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
k59_287295_1	28444.JODQ01000009_gene3728	2.6e-07	56.2	COG1716@1|root,COG1716@2|Bacteria,2GNU2@201174|Actinobacteria,4EFW3@85012|Streptosporangiales	201174|Actinobacteria	T	Protein of unknown function (DUF2662)	fhaA	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944,GO:0097159,GO:1901363	-	-	-	-	-	-	-	-	-	-	DUF3662,FHA,Yop-YscD_cpl
k59_1510263_1	99598.Cal7507_4821	6.72e-22	94.0	COG2197@1|root,COG2197@2|Bacteria,1G0N8@1117|Cyanobacteria,1HKG2@1161|Nostocales	1117|Cyanobacteria	K	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_1399025_1	172088.AUGA01000012_gene7173	1.64e-63	218.0	COG0506@1|root,COG4230@1|root,COG0506@2|Bacteria,COG4230@2|Bacteria,1MV93@1224|Proteobacteria,2TQPT@28211|Alphaproteobacteria,3JRB4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Oxidizes proline to glutamate for use as a carbon and nitrogen source	putA	-	1.2.1.88,1.5.5.2	ko:K13821	ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130	-	R00245,R00707,R00708,R01253,R04444,R04445,R05051	RC00080,RC00083,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000,ko03000	-	-	-	Aldedh,Pro_dh,Pro_dh-DNA_bdg
k59_509495_1	926569.ANT_28680	1.41e-77	240.0	COG2746@1|root,COG2746@2|Bacteria,2G6YM@200795|Chloroflexi	200795|Chloroflexi	V	Aminoglycoside 3-N-acetyltransferase	-	-	2.3.1.81	ko:K00662	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	Antibiotic_NAT
k59_509495_2	742767.HMPREF9456_01054	2.84e-06	53.1	COG1670@1|root,COG1670@2|Bacteria,4NQ4Z@976|Bacteroidetes,2FSTX@200643|Bacteroidia,22YCY@171551|Porphyromonadaceae	976|Bacteroidetes	J	Acetyltransferase (GNAT) domain	-	-	-	ko:K03817	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1,Acetyltransf_3
k59_1343353_1	616991.JPOO01000003_gene1728	4.15e-14	71.2	COG1529@1|root,COG1529@2|Bacteria,4NG6Q@976|Bacteroidetes,1IIS1@117743|Flavobacteriia	976|Bacteroidetes	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C2
k59_1343353_2	1202532.FF52_15752	5.47e-49	169.0	COG1807@1|root,COG1807@2|Bacteria,4NHXW@976|Bacteroidetes,1I0KK@117743|Flavobacteriia,2NU85@237|Flavobacterium	976|Bacteroidetes	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
k59_231785_1	1211115.ALIQ01000196_gene74	1.26e-70	231.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2TQMR@28211|Alphaproteobacteria,3NA1G@45404|Beijerinckiaceae	28211|Alphaproteobacteria	V	ABC transporter transmembrane region	msbA2	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_1621117_1	1336243.JAEA01000003_gene2163	6.97e-06	48.5	COG0044@1|root,COG0044@2|Bacteria,1MW10@1224|Proteobacteria,2TSQH@28211|Alphaproteobacteria,1JR0P@119045|Methylobacteriaceae	28211|Alphaproteobacteria	F	PFAM amidohydrolase	-	-	3.5.2.2	ko:K01464	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R02269,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Amidohydro_1,Urease_alpha
k59_1621117_2	266117.Rxyl_0369	2.62e-29	116.0	COG2141@1|root,COG2141@2|Bacteria,2H0K9@201174|Actinobacteria,4CTCQ@84995|Rubrobacteria	84995|Rubrobacteria	C	PFAM luciferase-like	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_1621120_1	1117314.PCIT_16340	1.45e-08	64.3	COG0823@1|root,COG1228@1|root,COG0823@2|Bacteria,COG1228@2|Bacteria,1MX3A@1224|Proteobacteria,1RMQZ@1236|Gammaproteobacteria,2Q039@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	QU	COG0823 Periplasmic component of the Tol biopolymer transport system	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,PD40
k59_398346_1	1122132.AQYH01000005_gene472	8.95e-138	395.0	COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,2TSWH@28211|Alphaproteobacteria,4B93X@82115|Rhizobiaceae	28211|Alphaproteobacteria	D	ATPases involved in chromosome partitioning	parA	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
k59_1621130_1	1380356.JNIK01000014_gene3447	6.56e-12	66.2	COG1278@1|root,COG1278@2|Bacteria,2IABV@201174|Actinobacteria	201174|Actinobacteria	K	cold-shock protein	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
k59_1400842_1	1068980.ARVW01000001_gene6258	4.95e-31	122.0	COG0477@1|root,COG2814@2|Bacteria,2GKHG@201174|Actinobacteria,4E0Y1@85010|Pseudonocardiales	201174|Actinobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
k59_1067326_1	385682.AFSL01000023_gene2163	2.26e-95	302.0	COG0188@1|root,COG0188@2|Bacteria,4NERI@976|Bacteroidetes,2FPAU@200643|Bacteroidia,3XJ07@558415|Marinilabiliaceae	976|Bacteroidetes	L	DNA Topoisomerase IV	parC	-	-	ko:K02621	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_topoisoIV
k59_1678734_1	1380391.JIAS01000004_gene2942	6.04e-85	255.0	COG1335@1|root,COG1335@2|Bacteria,1MV0W@1224|Proteobacteria,2TUNB@28211|Alphaproteobacteria,2JWCP@204441|Rhodospirillales	204441|Rhodospirillales	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
k59_1622779_1	671143.DAMO_2961	2.13e-12	64.7	COG0712@1|root,COG0712@2|Bacteria,2NPV0@2323|unclassified Bacteria	2|Bacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
k59_1622779_2	1340493.JNIF01000004_gene349	8.87e-63	207.0	COG0056@1|root,COG0056@2|Bacteria,3Y2R6@57723|Acidobacteria	57723|Acidobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
k59_1178564_1	1122138.AQUZ01000017_gene6577	6.41e-57	199.0	COG2909@1|root,COG2909@2|Bacteria,2I50W@201174|Actinobacteria,4DPMG@85009|Propionibacteriales	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	ko:K03556	-	-	-	-	ko00000,ko03000	-	-	-	AAA_16,GerE
k59_400210_1	1385517.N800_11340	1.99e-55	184.0	COG0491@1|root,COG0491@2|Bacteria,1RJ82@1224|Proteobacteria,1S8MG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	COG0491 Zn-dependent hydrolases, including glyoxylases	-	-	3.5.2.6	ko:K17837	ko01501,map01501	-	R06363	RC01499	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
k59_955975_1	765911.Thivi_0061	3.58e-07	55.8	COG0589@1|root,COG0730@1|root,COG0589@2|Bacteria,COG0730@2|Bacteria,1NBKV@1224|Proteobacteria,1SHMY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Universal stress protein family	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE,Usp
k59_1456881_1	391625.PPSIR1_34013	8.7e-09	58.2	COG1716@1|root,COG2114@1|root,COG2203@1|root,COG1716@2|Bacteria,COG2114@2|Bacteria,COG2203@2|Bacteria,1R45Z@1224|Proteobacteria,43AMH@68525|delta/epsilon subdivisions,2X61H@28221|Deltaproteobacteria,2Z38T@29|Myxococcales	28221|Deltaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	FHA,GAF,Guanylate_cyc
k59_177623_1	1234595.C725_2174	1.52e-16	85.5	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2TQVK@28211|Alphaproteobacteria,4BR9M@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_1289615_1	1232410.KI421418_gene2167	1.04e-51	181.0	COG2433@1|root,COG2433@2|Bacteria,1QW3W@1224|Proteobacteria,42RB0@68525|delta/epsilon subdivisions,2WN8G@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_177632_1	488538.SAR116_1189	3.03e-21	94.0	COG0697@1|root,COG0697@2|Bacteria,1PDMU@1224|Proteobacteria,2U0T9@28211|Alphaproteobacteria,4BQUA@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_121945_2	1340434.AXVA01000003_gene1556	1.01e-60	205.0	COG1123@1|root,COG4172@2|Bacteria,1UZK8@1239|Firmicutes,4HTUD@91061|Bacilli,1ZSDT@1386|Bacillus	91061|Bacilli	P	Oligopeptide/dipeptide transporter, C-terminal region	oppF	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_1178610_1	357808.RoseRS_4105	2.19e-42	145.0	COG0411@1|root,COG0411@2|Bacteria,2GABI@200795|Chloroflexi,376AR@32061|Chloroflexia	32061|Chloroflexia	E	PFAM ABC transporter related	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
k59_1178610_2	324602.Caur_3636	2.93e-19	84.0	COG0410@1|root,COG0410@2|Bacteria,2G69M@200795|Chloroflexi,374V9@32061|Chloroflexia	32061|Chloroflexia	E	PFAM ABC transporter related	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
k59_844618_1	909663.KI867150_gene2033	9.39e-07	53.9	COG0392@1|root,COG0392@2|Bacteria,1N7DR@1224|Proteobacteria,42N4R@68525|delta/epsilon subdivisions,2WS5Z@28221|Deltaproteobacteria,2MSHP@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
k59_844618_2	926569.ANT_15910	1.29e-53	184.0	COG0481@1|root,COG0481@2|Bacteria,2G5K2@200795|Chloroflexi	200795|Chloroflexi	J	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C
k59_566775_1	929558.SMGD1_1664	1.37e-09	63.9	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42UBD@68525|delta/epsilon subdivisions,2YRGP@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	T	7TM diverse intracellular signalling	-	-	-	ko:K20971	ko02025,map02025	-	-	-	ko00000,ko00001,ko01001,ko02022	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,HATPase_c
k59_844624_1	314278.NB231_11184	2.34e-111	337.0	COG0517@1|root,COG0538@1|root,COG0517@2|Bacteria,COG0538@2|Bacteria,1MW3J@1224|Proteobacteria,1RNMD@1236|Gammaproteobacteria,1WVYY@135613|Chromatiales	135613|Chromatiales	C	TIGRFAM isocitrate dehydrogenase, NADP-dependent	-	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	CBS,Iso_dh
k59_1289667_1	215803.DB30_4061	1.28e-21	97.4	COG0515@1|root,COG0515@2|Bacteria,1QX3Z@1224|Proteobacteria,430FI@68525|delta/epsilon subdivisions,2WVPS@28221|Deltaproteobacteria,2YWRZ@29|Myxococcales	28221|Deltaproteobacteria	T	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
k59_1178630_1	1550091.JROE01000005_gene1987	3.92e-05	45.8	COG0838@1|root,COG0838@2|Bacteria,4NQET@976|Bacteroidetes,1ISH2@117747|Sphingobacteriia	976|Bacteroidetes	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoA	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
k59_1400933_1	518766.Rmar_1079	3.37e-80	258.0	COG3661@1|root,COG3661@2|Bacteria,4NHE2@976|Bacteroidetes	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 67 family	-	-	3.2.1.139	ko:K01235	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_hydro_67C,Glyco_hydro_67M,Glyco_hydro_67N
k59_622338_1	1387197.AWGA01000033_gene1588	3e-09	58.5	COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,1RM8U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008784,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016853,GO:0016854,GO:0016855,GO:0019842,GO:0030170,GO:0030203,GO:0034645,GO:0036094,GO:0036361,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0047661,GO:0048037,GO:0050662,GO:0070279,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0097159,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	iPC815.YPO0321,iSBO_1134.SBO_4064,iSbBS512_1146.SbBS512_E4542,iYL1228.KPN_04440	Ala_racemase_C,Ala_racemase_N
k59_622338_2	1041138.KB890225_gene6170	1.7e-15	75.5	COG0454@1|root,COG0456@2|Bacteria,1N891@1224|Proteobacteria,2U9VU@28211|Alphaproteobacteria,4BMSV@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
k59_1178635_1	1123065.ATWL01000004_gene2984	4.1e-21	94.4	COG0483@1|root,COG0483@2|Bacteria,2GJQE@201174|Actinobacteria	201174|Actinobacteria	G	Inositol monophosphatase	suhB	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
k59_734232_1	1144343.PMI41_03926	7.88e-60	202.0	COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,2TU11@28211|Alphaproteobacteria,43H1T@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	DAO,DAO_C
k59_1456970_1	596154.Alide2_0568	1.26e-17	87.4	COG0617@1|root,COG0617@2|Bacteria,1MU2X@1224|Proteobacteria,2VIN5@28216|Betaproteobacteria,4AAWR@80864|Comamonadaceae	28216|Betaproteobacteria	J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'- nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases	cca	-	2.7.7.72	ko:K00974	ko03013,map03013	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd
k59_1456973_1	937777.Deipe_3128	7.69e-98	296.0	COG1082@1|root,COG1082@2|Bacteria,1WM56@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	Sugar phosphate isomerase epimerase	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
k59_956081_1	1140002.I570_02981	1.26e-25	104.0	COG2071@1|root,COG2071@2|Bacteria,1V1KC@1239|Firmicutes,4HI59@91061|Bacilli,4AZ7W@81852|Enterococcaceae	91061|Bacilli	S	Peptidase C26	-	-	-	ko:K07010	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_C26
k59_956081_2	5334.XP_003038246.1	1.6e-08	55.5	COG1028@1|root,KOG0725@2759|Eukaryota,38H5G@33154|Opisthokonta,3NWE0@4751|Fungi,3V039@5204|Basidiomycota,226S9@155619|Agaricomycetes,3W5QQ@5338|Agaricales	4751|Fungi	Q	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_1178661_1	1244869.H261_06776	1.25e-73	233.0	COG0683@1|root,COG0683@2|Bacteria,1MVV2@1224|Proteobacteria,2TRFU@28211|Alphaproteobacteria,2JWU0@204441|Rhodospirillales	204441|Rhodospirillales	E	COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
k59_511331_2	414684.RC1_2676	2.02e-30	112.0	COG0703@1|root,COG0703@2|Bacteria,1MUFJ@1224|Proteobacteria,2U76C@28211|Alphaproteobacteria,2JS5E@204441|Rhodospirillales	204441|Rhodospirillales	E	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	-	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
k59_177720_1	999423.HMPREF9161_00921	2.17e-87	282.0	COG0525@1|root,COG0525@2|Bacteria,1TPN4@1239|Firmicutes,4H21Q@909932|Negativicutes	909932|Negativicutes	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
k59_789705_1	686578.AFFX01000011_gene2686	9.81e-81	263.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,1RM9M@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006457,GO:0006605,GO:0006810,GO:0006886,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0032991,GO:0033036,GO:0033220,GO:0034613,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042802,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061077,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_1512217_2	58123.JOFJ01000001_gene3027	2.64e-12	67.4	COG1734@1|root,COG1734@2|Bacteria,2GJBE@201174|Actinobacteria,4EJJN@85012|Streptosporangiales	201174|Actinobacteria	T	Prokaryotic dksA/traR C4-type zinc finger	-	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
k59_1622916_1	479432.Sros_7286	1.08e-36	140.0	COG0285@1|root,COG0285@2|Bacteria,2GJP2@201174|Actinobacteria,4EIE3@85012|Streptosporangiales	201174|Actinobacteria	H	Mur ligase family, glutamate ligase domain	folC	GO:0003674,GO:0003824,GO:0004326,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006761,GO:0006807,GO:0008150,GO:0008152,GO:0008841,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046452,GO:0046483,GO:0046900,GO:0046901,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2447c	Mur_ligase_C,Mur_ligase_M
k59_789725_1	926569.ANT_25020	3.46e-101	301.0	COG0667@1|root,COG0667@2|Bacteria,2G5YU@200795|Chloroflexi	200795|Chloroflexi	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_734296_1	1121403.AUCV01000003_gene1742	5.86e-63	203.0	COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,42P5M@68525|delta/epsilon subdivisions,2WMFW@28221|Deltaproteobacteria,2MI2S@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_177749_1	234267.Acid_2146	2.88e-48	160.0	COG2318@1|root,COG2318@2|Bacteria	2|Bacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
k59_1289752_1	1121439.dsat_0641	3.33e-77	258.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,43BK2@68525|delta/epsilon subdivisions,2X6XX@28221|Deltaproteobacteria,2MH87@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Sigma-54 factor interaction domain-containing protein	-	-	-	ko:K02481,ko:K07712,ko:K07713	ko02020,map02020	M00497,M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,PAS_4,Response_reg,Sigma54_activat
k59_1235506_1	324057.Pjdr2_0047	5.1e-11	65.1	COG1929@1|root,COG1929@2|Bacteria,1TPSI@1239|Firmicutes,4HA91@91061|Bacilli,26R75@186822|Paenibacillaceae	91061|Bacilli	G	Belongs to the glycerate kinase type-1 family	glxK	-	2.7.1.165	ko:K00865	ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130	-	R08572	RC00002,RC00428	ko00000,ko00001,ko01000	-	-	-	Gly_kinase
k59_566898_1	234267.Acid_6688	8e-55	186.0	COG3547@1|root,COG3547@2|Bacteria,3Y52I@57723|Acidobacteria	57723|Acidobacteria	L	transposase IS116 IS110 IS902 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1289781_1	1379270.AUXF01000005_gene674	3.57e-20	89.4	COG0457@1|root,COG0457@2|Bacteria,1ZSPN@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Domain of unknown function (DUF4388)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4388,TPR_16,TPR_2
k59_1289781_2	1123267.JONN01000001_gene1386	2.1e-08	59.3	COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,2TT03@28211|Alphaproteobacteria,2JZZ0@204457|Sphingomonadales	204457|Sphingomonadales	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
k59_1235528_1	656519.Halsa_0338	9.99e-27	102.0	COG0353@1|root,COG0353@2|Bacteria,1TR87@1239|Firmicutes,2487H@186801|Clostridia,3WB9U@53433|Halanaerobiales	186801|Clostridia	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	HHH,RecR,Toprim_4
k59_1235528_2	679197.HMPREF9336_00619	4.58e-11	64.7	COG0558@1|root,COG0558@2|Bacteria,2GK5D@201174|Actinobacteria	201174|Actinobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0030312,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
k59_956182_2	1056820.KB900652_gene3254	0.000482	45.8	COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,1RMD6@1236|Gammaproteobacteria,2PN0S@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	M	Mur ligase family, catalytic domain	murE	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008765,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	iECO103_1326.ECO103_0087,iECO111_1330.ECO111_0088,iECW_1372.ECW_m0084,iEKO11_1354.EKO11_3829,iWFL_1372.ECW_m0084,ic_1306.c0103	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_1512277_1	338963.Pcar_2777	8.36e-24	95.9	COG0558@1|root,COG0558@2|Bacteria,1RE0I@1224|Proteobacteria,42WBZ@68525|delta/epsilon subdivisions,2WVT2@28221|Deltaproteobacteria,43V8C@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
k59_1512277_2	1035308.AQYY01000001_gene1240	1.97e-09	61.2	COG0204@1|root,COG0204@2|Bacteria,1UMJA@1239|Firmicutes,249AV@186801|Clostridia,25ZY4@186807|Peptococcaceae	186801|Clostridia	I	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family	plsC_1	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
k59_1012249_1	948106.AWZT01000074_gene5577	2.4e-08	58.5	COG2995@1|root,COG2995@2|Bacteria,1RAQ9@1224|Proteobacteria,2VRNW@28216|Betaproteobacteria,1K7FQ@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Paraquat-inducible protein A	-	-	-	ko:K03808	-	-	-	-	ko00000	-	-	-	PqiA
k59_1567968_1	366394.Smed_5761	2.11e-21	97.8	COG2114@1|root,COG2267@1|root,COG2114@2|Bacteria,COG2267@2|Bacteria,1QU5X@1224|Proteobacteria,2TW12@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Guanylate_cyc
k59_901286_1	1033810.HLPCO_002685	6.88e-62	212.0	COG2217@1|root,COG2217@2|Bacteria,2NNPJ@2323|unclassified Bacteria	2|Bacteria	P	E1-E2 ATPase	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
k59_1567974_1	869213.JCM21142_104417	7.64e-19	94.0	COG1672@1|root,COG1672@2|Bacteria,4NN64@976|Bacteroidetes,47UYI@768503|Cytophagia	976|Bacteroidetes	S	PFAM Archaeal ATPase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1235551_1	324602.Caur_3885	8e-49	167.0	COG1475@1|root,COG1475@2|Bacteria,2G735@200795|Chloroflexi,375G7@32061|Chloroflexia	32061|Chloroflexia	K	DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	DUF4032
k59_478388_1	1163408.UU9_01409	1.46e-17	84.7	COG3420@1|root,COG3420@2|Bacteria,1MVCD@1224|Proteobacteria,1RQ8F@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Nitrous oxidase accessory protein	nosD	-	-	ko:K07218	-	-	-	-	ko00000	-	-	-	NosD
k59_699753_1	1136138.JH604622_gene2494	5.66e-18	81.3	COG3193@1|root,COG3193@2|Bacteria,1N08N@1224|Proteobacteria,1S8SV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Glcg protein	glcG	-	-	-	-	-	-	-	-	-	-	-	Haem_degrading
k59_420809_1	102107.XP_008234847.1	9.88e-36	138.0	COG5505@1|root,2QQM4@2759|Eukaryota,37RG0@33090|Viridiplantae,3GC7K@35493|Streptophyta,4JM9I@91835|fabids	35493|Streptophyta	S	Protein of unknown function (DUF819)	-	-	-	-	-	-	-	-	-	-	-	-	DUF819
k59_1088417_1	1121930.AQXG01000006_gene878	4.46e-45	154.0	COG1595@1|root,COG1595@2|Bacteria,4NEFR@976|Bacteroidetes,1IXQF@117747|Sphingobacteriia	976|Bacteroidetes	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_253475_1	1048834.TC41_1382	1.2e-23	102.0	COG0612@1|root,COG0612@2|Bacteria,1TP5I@1239|Firmicutes,4HBBF@91061|Bacilli,279JD@186823|Alicyclobacillaceae	91061|Bacilli	S	Belongs to the peptidase M16 family	mlpA	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_1034395_1	265072.Mfla_2106	3.05e-108	322.0	COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,2VIWS@28216|Betaproteobacteria,2KKV0@206350|Nitrosomonadales	206350|Nitrosomonadales	NU	PFAM type II secretion system protein E	-	-	-	ko:K02670	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
k59_1256544_1	880070.Cycma_1980	5.87e-64	215.0	COG2010@1|root,COG2133@1|root,COG2010@2|Bacteria,COG2133@2|Bacteria,4NDV1@976|Bacteroidetes,47JGM@768503|Cytophagia	976|Bacteroidetes	G	COGs COG2133 Glucose sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3,GSDH
k59_531958_1	269799.Gmet_1728	1.18e-27	115.0	COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,42KZZ@68525|delta/epsilon subdivisions,2WJWV@28221|Deltaproteobacteria,43SQT@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	PFAM Glu Leu Phe Val dehydrogenase	-	-	1.4.1.2	ko:K15371	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	-	R00243	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	Bac_GDH,ELFV_dehydrog
k59_31508_1	100226.SCO5924	1.57e-08	60.8	COG1178@1|root,COG1178@2|Bacteria,2GKDH@201174|Actinobacteria	201174|Actinobacteria	P	ABC-type Fe3 transport system permease component	-	-	-	ko:K02011,ko:K02063	ko02010,map02010	M00190,M00191	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10,3.A.1.19	-	-	BPD_transp_1,SBP_bac_6
k59_1532396_1	331869.BAL199_19391	1.85e-27	109.0	COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,2TXA6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	CH	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_1532396_2	1121017.AUFG01000019_gene2362	2.34e-05	47.8	COG0684@1|root,COG0684@2|Bacteria,2I8VQ@201174|Actinobacteria	201174|Actinobacteria	H	Methyltransferase	-	-	4.1.3.17	ko:K10218	ko00362,ko00660,ko01120,map00362,map00660,map01120	-	R00008,R00350	RC00067,RC00502,RC01205	ko00000,ko00001,ko01000	-	-	-	RraA-like
k59_1532403_1	378806.STAUR_4474	5.43e-08	61.2	COG1716@1|root,COG1716@2|Bacteria,1MXT7@1224|Proteobacteria,438SD@68525|delta/epsilon subdivisions,2X3Z5@28221|Deltaproteobacteria,2YXNI@29|Myxococcales	28221|Deltaproteobacteria	T	Forkhead associated domain	-	-	-	-	-	-	-	-	-	-	-	-	Yop-YscD_cpl
k59_810185_1	1123229.AUBC01000040_gene3838	5.67e-17	85.5	COG4584@1|root,COG4584@2|Bacteria,1MU2G@1224|Proteobacteria,2TVA2@28211|Alphaproteobacteria,3JRH7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r4_2,rve
k59_587018_2	1123508.JH636440_gene2902	2.91e-34	133.0	COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,2IWUM@203682|Planctomycetes	203682|Planctomycetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
k59_1256586_2	252305.OB2597_16667	1.53e-103	311.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2TSA7@28211|Alphaproteobacteria,2PFZ3@252301|Oceanicola	28211|Alphaproteobacteria	L	Transposase domain (DUF772)	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_87132_1	1121875.KB907549_gene1913	7.03e-74	247.0	COG4447@1|root,COG4447@2|Bacteria,4NI14@976|Bacteroidetes,1I04K@117743|Flavobacteriia	976|Bacteroidetes	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
k59_197769_1	543632.JOJL01000064_gene1455	1.2e-19	90.9	COG0038@1|root,COG2524@1|root,COG0038@2|Bacteria,COG2524@2|Bacteria,2GPPN@201174|Actinobacteria,4DBG8@85008|Micromonosporales	201174|Actinobacteria	P	Voltage gated chloride channel	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,Voltage_CLC
k59_531998_2	1070319.CAGGBEG34_70007	2.94e-18	87.0	COG1354@1|root,COG1354@2|Bacteria,1MVCN@1224|Proteobacteria,2VKE7@28216|Betaproteobacteria,1K0D1@119060|Burkholderiaceae	28216|Betaproteobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
k59_1199205_1	323261.Noc_2817	5.55e-36	130.0	COG2020@1|root,COG2020@2|Bacteria,1RJNV@1224|Proteobacteria,1SGB2@1236|Gammaproteobacteria,1X1KG@135613|Chromatiales	135613|Chromatiales	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
k59_1199205_2	743720.Psefu_3230	3.04e-11	63.2	COG0500@1|root,COG2226@2|Bacteria,1MV4M@1224|Proteobacteria,1RMWY@1236|Gammaproteobacteria,1YUVM@136845|Pseudomonas putida group	1236|Gammaproteobacteria	J	Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM)	cmoA	GO:0002097,GO:0002098,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360	-	ko:K15256	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_25
k59_310466_1	926569.ANT_00490	1.85e-32	125.0	COG0433@1|root,COG0433@2|Bacteria,2G62A@200795|Chloroflexi	200795|Chloroflexi	S	Domain of unknown function DUF87	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87,HAS-barrel
k59_253543_1	1089551.KE386572_gene1743	3.45e-62	215.0	COG3291@1|root,COG3291@2|Bacteria,1R5MU@1224|Proteobacteria,2U12Y@28211|Alphaproteobacteria,4BRG6@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	PKD
k59_1199218_1	1047013.AQSP01000105_gene1436	8.13e-60	198.0	COG2421@1|root,COG2421@2|Bacteria,2NR72@2323|unclassified Bacteria	2|Bacteria	C	Acetamidase/Formamidase family	-	-	-	-	-	-	-	-	-	-	-	-	FmdA_AmdA
k59_978092_1	1463821.JOGR01000003_gene917	2.83e-74	229.0	2CEY7@1|root,2Z8CG@2|Bacteria,2GKI0@201174|Actinobacteria,4EYEJ@85014|Glycomycetales	201174|Actinobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1532462_1	1166948.JPZL01000002_gene1262	1.22e-28	118.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1XHGD@135619|Oceanospirillales	135619|Oceanospirillales	T	signal transduction protein containing a membrane domain, an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	CheR,EAL,GGDEF
k59_1144628_1	382464.ABSI01000020_gene125	5.82e-48	176.0	COG0471@1|root,COG0471@2|Bacteria,46UA9@74201|Verrucomicrobia,2ITKW@203494|Verrucomicrobiae	203494|Verrucomicrobiae	P	Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,Na_sulph_symp,TrkA_C
k59_1477791_1	204669.Acid345_0280	1.39e-61	214.0	COG0574@1|root,COG0784@1|root,COG0574@2|Bacteria,COG0784@2|Bacteria,3Y7G5@57723|Acidobacteria	57723|Acidobacteria	G	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PPDK_N
k59_1034499_1	1121904.ARBP01000039_gene2537	4.45e-54	184.0	COG2433@1|root,COG2433@2|Bacteria,4PMMU@976|Bacteroidetes	976|Bacteroidetes	S	COG3436 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
k59_1642440_2	592029.DDD_1936	1.03e-51	177.0	COG3067@1|root,COG3067@2|Bacteria,4NI67@976|Bacteroidetes,1HZZ9@117743|Flavobacteriia,3HJD2@363408|Nonlabens	976|Bacteroidetes	P	Bacterial Na+/H+ antiporter B (NhaB)	-	-	-	ko:K03314	-	-	-	-	ko00000,ko02000	2.A.34.1	-	-	NhaB
k59_197821_1	1249997.JHZW01000003_gene2483	8.97e-61	204.0	COG3119@1|root,COG3119@2|Bacteria,4NHH7@976|Bacteroidetes,1HX4R@117743|Flavobacteriia,2PIFD@252356|Maribacter	976|Bacteroidetes	P	Domain of unknown function (DUF4976)	atsA_1	-	-	ko:K01138	-	-	-	-	ko00000,ko01000	-	-	-	DUF4976,Sulfatase
k59_364899_1	986075.CathTA2_1034	4.04e-137	405.0	COG1884@1|root,COG1884@2|Bacteria,1TQAD@1239|Firmicutes,4H9QB@91061|Bacilli	91061|Bacilli	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
k59_1256662_1	1121106.JQKB01000008_gene1377	1.23e-09	63.2	COG0667@1|root,COG0667@2|Bacteria,1R5BH@1224|Proteobacteria,2TS0A@28211|Alphaproteobacteria,2JVHZ@204441|Rhodospirillales	204441|Rhodospirillales	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_1311531_1	243231.GSU2862	4.3e-122	383.0	COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,42NAW@68525|delta/epsilon subdivisions,2WISU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_699908_1	365528.KB891285_gene4946	1.36e-34	123.0	COG0853@1|root,COG0853@2|Bacteria,2IHTC@201174|Actinobacteria,4ESSN@85013|Frankiales	201174|Actinobacteria	H	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine	panD	-	4.1.1.11	ko:K01579	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R00489	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Asp_decarbox
k59_699908_2	1347086.CCBA010000031_gene808	2.69e-08	55.1	COG0414@1|root,COG0414@2|Bacteria,1TP7A@1239|Firmicutes,4HAIQ@91061|Bacilli,1ZAV5@1386|Bacillus	91061|Bacilli	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
k59_532093_1	646529.Desaci_2383	7.17e-32	125.0	COG0045@1|root,COG0045@2|Bacteria,1UYAU@1239|Firmicutes,24FES@186801|Clostridia,264FC@186807|Peptococcaceae	186801|Clostridia	C	Belongs to the succinate malate CoA ligase beta subunit family	-	-	6.2.1.18,6.2.1.5	ko:K01903,ko:K15232	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R01322,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Citrate_bind
k59_532093_2	439375.Oant_2226	3.37e-07	52.4	COG1028@1|root,COG1028@2|Bacteria,1N4J7@1224|Proteobacteria,2TSDX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_253624_1	622637.KE124774_gene3911	1.09e-57	193.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria,36X6J@31993|Methylocystaceae	28211|Alphaproteobacteria	I	Thiolase, C-terminal domain	phbA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_1700873_1	1123242.JH636434_gene4587	7.63e-46	166.0	COG0367@1|root,COG0367@2|Bacteria,2IXAI@203682|Planctomycetes	203682|Planctomycetes	E	Asparagine synthase, glutamine-hydrolyzing	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
k59_142247_1	143224.JQMD01000002_gene3270	2.59e-08	55.8	COG1253@1|root,COG1253@2|Bacteria,4NE7C@976|Bacteroidetes,1HYD7@117743|Flavobacteriia	976|Bacteroidetes	S	COGs COG1253 Hemolysins and related protein containing CBS domains	-	-	-	-	-	-	-	-	-	-	-	-	CBS,DUF21
k59_142247_2	309807.SRU_2390	2.08e-07	54.7	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Cu_amine_oxidN1,Phytase-like
k59_1642496_1	391038.Bphy_1987	3.26e-89	273.0	COG1960@1|root,COG1960@2|Bacteria,1MU2V@1224|Proteobacteria,2VI1V@28216|Betaproteobacteria,1K1EX@119060|Burkholderiaceae	28216|Betaproteobacteria	C	acyl-CoA dehydrogenase	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_1588627_1	443144.GM21_0962	1.66e-52	180.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WJ88@28221|Deltaproteobacteria,43TKB@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	response regulator	ntrX	-	-	ko:K13599	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1199318_1	62928.azo3052	4.99e-24	104.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VJJS@28216|Betaproteobacteria,2KY7V@206389|Rhodocyclales	206389|Rhodocyclales	I	AMP-binding enzyme C-terminal domain	-	-	6.2.1.25	ko:K04110	ko00362,ko00627,ko01100,ko01120,map00362,map00627,map01100,map01120	-	R01422	RC00004,RC00174	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C
k59_810346_1	1089551.KE386572_gene3104	1.01e-21	89.0	2DWFS@1|root,32V1J@2|Bacteria,1MZ9A@1224|Proteobacteria,2UDME@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Nitrile hydratase beta subunit	-	-	4.2.1.84	ko:K20807	ko00364,ko00380,ko00627,ko00643,ko01120,map00364,map00380,map00627,map00643,map01120	-	R04020,R05379,R05596,R07780,R07854	RC00483,RC01345,RC01432	ko00000,ko00001,ko01000	-	-	-	NHase_beta
k59_810346_2	1380394.JADL01000002_gene1249	1.42e-10	58.2	2DBV6@1|root,32TY6@2|Bacteria,1N0TC@1224|Proteobacteria,2UCAJ@28211|Alphaproteobacteria,2JXVR@204441|Rhodospirillales	204441|Rhodospirillales	S	Nitrile hydratase beta subunit	-	-	4.2.1.84	ko:K20807	ko00364,ko00380,ko00627,ko00643,ko01120,map00364,map00380,map00627,map00643,map01120	-	R04020,R05379,R05596,R07780,R07854	RC00483,RC01345,RC01432	ko00000,ko00001,ko01000	-	-	-	NHase_beta
k59_364961_1	670307.HYPDE_25893	1.83e-55	178.0	COG1917@1|root,COG1917@2|Bacteria,1MZFB@1224|Proteobacteria	1224|Proteobacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_364961_2	582899.Hden_0609	1.01e-10	62.4	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,2TW3X@28211|Alphaproteobacteria,3N7JR@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS,PAS_8,PAS_9,Sigma54_activat
k59_310617_2	1095769.CAHF01000025_gene675	3.05e-09	59.3	2EJZ3@1|root,33DPP@2|Bacteria,1NKIC@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1311604_1	290397.Adeh_1023	3.04e-52	177.0	COG0798@1|root,COG0798@2|Bacteria,1MUXY@1224|Proteobacteria,42M0Z@68525|delta/epsilon subdivisions,2WK36@28221|Deltaproteobacteria,2Z0TJ@29|Myxococcales	28221|Deltaproteobacteria	P	arsenical-resistance protein	arsB	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
k59_587196_1	234267.Acid_4465	7.63e-18	86.3	COG3547@1|root,COG3547@2|Bacteria,3Y5SI@57723|Acidobacteria	57723|Acidobacteria	L	transposase IS116 IS110 IS902 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_810374_1	1123393.KB891333_gene2646	1.68e-71	231.0	COG1355@1|root,COG2078@1|root,COG1355@2|Bacteria,COG2078@2|Bacteria,1MXK5@1224|Proteobacteria,2VKXP@28216|Betaproteobacteria,1KS3P@119069|Hydrogenophilales	119069|Hydrogenophilales	S	Memo-like protein	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	AMMECR1,Memo
k59_364997_1	1089550.ATTH01000001_gene1101	1.9e-22	98.2	COG0642@1|root,COG0745@1|root,COG3292@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,COG3292@2|Bacteria,4NDXU@976|Bacteroidetes	976|Bacteroidetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y
k59_253693_1	1392838.AWNM01000096_gene3058	1.03e-06	50.4	COG1846@1|root,COG1846@2|Bacteria,1PC1I@1224|Proteobacteria,2WB7W@28216|Betaproteobacteria,3T7ZW@506|Alcaligenaceae	28216|Betaproteobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	ko:K06075	-	-	-	-	ko00000,ko03000	-	-	-	-
k59_810400_2	861299.J421_1913	0.000164	43.1	COG0828@1|root,COG0828@2|Bacteria,1ZU81@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Ribosomal protein S21	-	-	-	ko:K02970	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S21
k59_1700976_1	1437824.BN940_16071	6.66e-09	60.8	COG3335@1|root,COG3335@2|Bacteria,1MW7X@1224|Proteobacteria,2VMDX@28216|Betaproteobacteria,3T7U9@506|Alcaligenaceae	28216|Betaproteobacteria	L	DDE superfamily endonuclease	-	-	-	ko:K07494	-	-	-	-	ko00000	-	-	-	DDE_3,HTH_23,HTH_29,HTH_32
k59_810441_1	259536.Psyc_1901	3.91e-28	114.0	COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,1RP4T@1236|Gammaproteobacteria,3NIR7@468|Moraxellaceae	1236|Gammaproteobacteria	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_365065_1	637390.AFOH01000120_gene544	1.53e-43	147.0	COG0328@1|root,COG0328@2|Bacteria,1RCZ1@1224|Proteobacteria,1S3YC@1236|Gammaproteobacteria,2NCW8@225057|Acidithiobacillales	225057|Acidithiobacillales	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhA	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_H
k59_700056_1	497321.C664_09305	2.86e-36	137.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VI3F@28216|Betaproteobacteria,2KUP6@206389|Rhodocyclales	206389|Rhodocyclales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_756961_1	118161.KB235922_gene5825	5.1e-56	186.0	COG5433@1|root,COG5433@2|Bacteria,1G0VN@1117|Cyanobacteria,3VJBK@52604|Pleurocapsales	1117|Cyanobacteria	L	DDE_Tnp_1-associated	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
k59_1051786_1	376686.Fjoh_3284	1.71e-126	379.0	COG5361@1|root,COG5361@2|Bacteria,4NE76@976|Bacteroidetes,1I8E2@117743|Flavobacteriia,2NS5X@237|Flavobacterium	976|Bacteroidetes	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_883918_1	591001.Acfer_1464	0.000263	49.7	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,4H77Z@909932|Negativicutes	909932|Negativicutes	V	ABC transporter transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	ABC_membrane,ABC_tran
k59_1051798_1	1244869.H261_06576	1.15e-27	111.0	COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,2TUIT@28211|Alphaproteobacteria,2JRZP@204441|Rhodospirillales	204441|Rhodospirillales	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
k59_1496857_2	1415166.NONO_c69910	2.14e-17	79.7	COG1950@1|root,COG1950@2|Bacteria,2IHP5@201174|Actinobacteria,4G28G@85025|Nocardiaceae	201174|Actinobacteria	S	Mycobacterial 4 TMS phage holin, superfamily IV	-	-	-	ko:K08972	-	-	-	-	ko00000	-	-	-	Phage_holin_4_2
k59_329841_1	349741.Amuc_0650	3.45e-45	162.0	COG0275@1|root,COG0275@2|Bacteria,46SPT@74201|Verrucomicrobia,2IU2A@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
k59_770909_1	203122.Sde_3939	4.07e-51	181.0	COG2199@1|root,COG3706@2|Bacteria,1MWHH@1224|Proteobacteria,1RRU7@1236|Gammaproteobacteria,464KE@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,GGDEF
k59_883935_1	746128.CADAFUBP00008914	1.83e-09	63.2	COG0500@1|root,KOG1269@2759|Eukaryota,38FGK@33154|Opisthokonta,3NYCG@4751|Fungi,3QV2V@4890|Ascomycota,20T2H@147545|Eurotiomycetes,3SF9R@5042|Eurotiales	4751|Fungi	H	UbiE COQ5 methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_31
k59_1771855_1	471852.Tcur_2810	3.23e-82	254.0	COG1064@1|root,COG1064@2|Bacteria,2GKNW@201174|Actinobacteria,4ENHR@85012|Streptosporangiales	201174|Actinobacteria	S	Zinc-binding dehydrogenase	sadh	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_1163531_1	1379270.AUXF01000002_gene1585	7.88e-65	221.0	COG0515@1|root,COG0515@2|Bacteria,1ZUMJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
k59_48413_1	1380387.JADM01000019_gene3279	1.88e-15	73.6	COG2716@1|root,COG2716@2|Bacteria,1R7W7@1224|Proteobacteria,1RSDP@1236|Gammaproteobacteria,1XJWK@135619|Oceanospirillales	135619|Oceanospirillales	E	glycine cleavage system	-	-	-	ko:K03567	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	ACT_6
k59_48413_2	998088.B565_3342	6.73e-26	104.0	COG0329@1|root,COG0329@2|Bacteria,1MUCM@1224|Proteobacteria,1RNH9@1236|Gammaproteobacteria,1Y55W@135624|Aeromonadales	135624|Aeromonadales	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
k59_1163535_1	414684.RC1_0977	1.15e-77	247.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,2TSK4@28211|Alphaproteobacteria,2JRCD@204441|Rhodospirillales	204441|Rhodospirillales	E	Belongs to the alpha-IPM synthase homocitrate synthase family	-	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
k59_1163535_2	1122201.AUAZ01000008_gene453	8.54e-09	56.2	COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,1RP5K@1236|Gammaproteobacteria,464RP@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iECUMN_1333.ECUMN_0566,iJN746.PP_2905	DALR_2,tRNA-synt_1e,tRNA-synt_1g
k59_438367_1	926569.ANT_03430	2.65e-53	181.0	COG1409@1|root,COG1409@2|Bacteria,2G88X@200795|Chloroflexi	200795|Chloroflexi	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
k59_497184_1	498761.HM1_1471	3.14e-70	224.0	COG0538@1|root,COG0538@2|Bacteria,1UHPE@1239|Firmicutes,25F02@186801|Clostridia	186801|Clostridia	C	Isocitrate/isopropylmalate dehydrogenase	icd	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
k59_1496898_1	391612.CY0110_00770	8.66e-87	269.0	COG1215@1|root,COG1215@2|Bacteria,1G44I@1117|Cyanobacteria,3KHF3@43988|Cyanothece	1117|Cyanobacteria	M	glycosyl transferase family 2	-	-	2.4.1.80	ko:K00720	ko00600,ko01100,map00600,map01100	M00066	R01497	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko02000	4.D.1.4	GT21	-	Glyco_transf_21
k59_883967_1	470704.XP_007759918.1	2.08e-44	159.0	COG0015@1|root,KOG2700@2759|Eukaryota,38BFX@33154|Opisthokonta,3NX87@4751|Fungi,3QRN3@4890|Ascomycota,20EI9@147545|Eurotiomycetes	4751|Fungi	F	Adenylosuccinate lyase C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	ADSL_C,Lyase_1
k59_658485_1	1185652.USDA257_c12650	4.43e-43	154.0	COG0329@1|root,COG0329@2|Bacteria,1MXM5@1224|Proteobacteria,2TUAG@28211|Alphaproteobacteria,4BBDG@82115|Rhizobiaceae	28211|Alphaproteobacteria	EM	Belongs to the DapA family	dapAb	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
k59_549318_1	483219.LILAB_26520	4.35e-37	142.0	COG3227@1|root,COG3227@2|Bacteria,1QXPY@1224|Proteobacteria,43E6J@68525|delta/epsilon subdivisions,2X7H9@28221|Deltaproteobacteria,2Z3GG@29|Myxococcales	28221|Deltaproteobacteria	E	Fungalysin metallopeptidase (M36)	-	-	-	ko:K01417	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	FTP,Peptidase_M36
k59_160524_1	1232410.KI421420_gene3227	5.39e-78	259.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,43U53@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	AcrB/AcrD/AcrF family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran,OEP
k59_1496914_1	118166.JH976537_gene4640	2.06e-79	253.0	COG0446@1|root,COG0607@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,1G40A@1117|Cyanobacteria,1HI0P@1150|Oscillatoriales	1117|Cyanobacteria	P	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim,Rhodanese
k59_104888_1	1030157.AFMP01000016_gene2484	1.93e-36	132.0	COG0566@1|root,COG0566@2|Bacteria,1MWCM@1224|Proteobacteria,2TUG7@28211|Alphaproteobacteria,2K163@204457|Sphingomonadales	204457|Sphingomonadales	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	-	-	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
k59_1330995_1	2754.EH55_12475	4.01e-19	87.0	COG0201@1|root,COG0201@2|Bacteria,3TA0Z@508458|Synergistetes	508458|Synergistetes	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
k59_1330995_2	1123376.AUIU01000005_gene1215	5.14e-26	100.0	COG0200@1|root,COG0200@2|Bacteria,3J0PY@40117|Nitrospirae	40117|Nitrospirae	J	binds to the 23S rRNA	rplO	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
k59_719020_1	518766.Rmar_1511	6.91e-67	215.0	COG2957@1|root,COG2957@2|Bacteria,4NGF8@976|Bacteroidetes	976|Bacteroidetes	E	Belongs to the agmatine deiminase family	aguA	-	3.5.3.12	ko:K10536	ko00330,ko01100,map00330,map01100	-	R01416	RC00177	ko00000,ko00001,ko01000	-	-	-	PAD_porph
k59_1771930_1	335543.Sfum_1498	2.9e-22	97.4	COG4962@1|root,COG4962@2|Bacteria,1R7EN@1224|Proteobacteria,42NAK@68525|delta/epsilon subdivisions,2WIYX@28221|Deltaproteobacteria,2MQ42@213462|Syntrophobacterales	28221|Deltaproteobacteria	U	PFAM Type II secretion system protein E	-	-	-	ko:K02283,ko:K03609	-	-	-	-	ko00000,ko02035,ko02044,ko03036,ko04812	-	-	-	CbiA,FHA,T2SSE
k59_1718316_1	207559.Dde_3214	2.77e-59	194.0	COG1683@1|root,COG3272@1|root,COG1683@2|Bacteria,COG3272@2|Bacteria,1MXYZ@1224|Proteobacteria,42M4E@68525|delta/epsilon subdivisions,2WKFT@28221|Deltaproteobacteria,2M938@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1722)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1722,DUF523
k59_1718316_2	1340493.JNIF01000004_gene1120	9.19e-22	90.1	COG4276@1|root,COG4276@2|Bacteria,3Y57N@57723|Acidobacteria	57723|Acidobacteria	S	Pfam Polyketide cyclase dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
k59_719037_1	667014.Thein_1301	6.37e-51	174.0	COG0124@1|root,COG0124@2|Bacteria,2GGZ4@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	J	Histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
k59_719037_2	404589.Anae109_1474	0.000615	42.0	COG2199@1|root,COG2204@1|root,COG2204@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,42Q9F@68525|delta/epsilon subdivisions,2WMM7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
k59_104919_1	1449069.JMLO01000001_gene1886	3.43e-34	122.0	COG2128@1|root,COG2128@2|Bacteria,2I829@201174|Actinobacteria,4FZ82@85025|Nocardiaceae	201174|Actinobacteria	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
k59_329963_1	485913.Krac_2547	5.06e-59	196.0	COG0492@1|root,COG0492@2|Bacteria,2G5Z5@200795|Chloroflexi	2|Bacteria	C	FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Glutaredoxin,Pyr_redox_2
k59_942029_2	1353529.M899_3206	1.83e-28	111.0	COG1073@1|root,COG1073@2|Bacteria,1MXAT@1224|Proteobacteria	1224|Proteobacteria	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
k59_383762_1	936455.KI421499_gene4167	8.12e-53	180.0	COG0028@1|root,COG0028@2|Bacteria,1MWC3@1224|Proteobacteria,2TTA2@28211|Alphaproteobacteria,3JS9T@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EH	Thiamine pyrophosphate enzyme, central domain	MA20_15555	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_884050_1	331869.BAL199_12036	1.52e-66	211.0	COG0607@1|root,COG4275@1|root,COG0607@2|Bacteria,COG4275@2|Bacteria,1MYDE@1224|Proteobacteria,2TRC3@28211|Alphaproteobacteria,4BQ5U@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	P	Chromate resistance exported protein	-	-	-	-	-	-	-	-	-	-	-	-	Chrome_Resist,Rhodanese
k59_48503_1	945713.IALB_2112	2.27e-96	296.0	COG1884@1|root,COG1884@2|Bacteria	2|Bacteria	I	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly	icmA	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
k59_884058_1	1048983.EL17_01495	3.59e-47	169.0	COG3930@1|root,COG3930@2|Bacteria,4NG5D@976|Bacteroidetes,47M5T@768503|Cytophagia	976|Bacteroidetes	S	DUF1704	-	-	-	-	-	-	-	-	-	-	-	-	DUF1704
k59_1331064_1	983920.Y88_0111	1.24e-108	320.0	COG0388@1|root,COG0388@2|Bacteria,1MXG5@1224|Proteobacteria,2TVCS@28211|Alphaproteobacteria,2K0V3@204457|Sphingomonadales	204457|Sphingomonadales	S	N-carbamoylputrescine amidase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
k59_1548503_2	1169143.KB911038_gene5992	2.23e-34	128.0	COG2391@1|root,COG2391@2|Bacteria,1PF9B@1224|Proteobacteria,2VKKD@28216|Betaproteobacteria,1K2C9@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Sulphur transport	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
k59_719080_1	1218074.BAXZ01000013_gene2953	4.96e-07	57.0	COG1807@1|root,COG1807@2|Bacteria,1NPGH@1224|Proteobacteria	1224|Proteobacteria	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_658569_1	926569.ANT_12650	6.21e-43	154.0	COG0173@1|root,COG0173@2|Bacteria,2G5RX@200795|Chloroflexi	200795|Chloroflexi	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
k59_1771995_1	1380347.JNII01000007_gene607	1.41e-15	78.6	COG1396@1|root,COG1396@2|Bacteria,2INQP@201174|Actinobacteria,4EVM8@85013|Frankiales	201174|Actinobacteria	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_3,HTH_31
k59_1106649_1	1128421.JAGA01000003_gene3720	5.19e-58	188.0	COG1573@1|root,COG1573@2|Bacteria,2NP99@2323|unclassified Bacteria	2|Bacteria	L	Uracil DNA glycosylase superfamily	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
k59_1216475_1	243230.DR_1164	2.62e-30	115.0	COG0414@1|root,COG0414@2|Bacteria,1WIB9@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
k59_213353_1	697281.Mahau_0309	7.64e-17	84.7	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,42F9E@68295|Thermoanaerobacterales	186801|Clostridia	V	ABC transporter, transmembrane region	-	-	-	ko:K18889	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106.13,3.A.1.106.5	-	-	ABC_membrane,ABC_tran
k59_330025_1	402881.Plav_0017	7.55e-30	119.0	COG4191@1|root,COG4191@2|Bacteria,1MWR3@1224|Proteobacteria,2TSS0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Histidine kinase	regB	-	2.7.13.3	ko:K15011	ko02020,map02020	M00523	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
k59_330025_2	269796.Rru_A0126	9.07e-33	122.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2TSC5@28211|Alphaproteobacteria,2JPQ5@204441|Rhodospirillales	204441|Rhodospirillales	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1385495_1	1437603.BMON_0116	2.53e-38	145.0	COG0480@1|root,COG0480@2|Bacteria,2GKB3@201174|Actinobacteria,4CYTB@85004|Bifidobacteriales	201174|Actinobacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_549410_1	498211.CJA_0176	2.08e-46	150.0	COG3288@1|root,COG3288@2|Bacteria,1MZ3E@1224|Proteobacteria,1S6HX@1236|Gammaproteobacteria,1FHFU@10|Cellvibrio	1236|Gammaproteobacteria	C	4TM region of pyridine nucleotide transhydrogenase, mitoch	pnaB	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB_4TM
k59_549410_2	377629.TERTU_0902	9.2e-21	91.7	COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,1RMR4@1236|Gammaproteobacteria,2PMK0@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	C	NAD(P) transhydrogenase beta subunit	pntB	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
k59_438500_1	861299.J421_2927	2.04e-59	200.0	COG0621@1|root,COG0621@2|Bacteria,1ZT70@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,UPF0004
k59_438500_2	941449.dsx2_0207	3.3e-05	47.4	COG2834@1|root,COG2834@2|Bacteria,1PDTV@1224|Proteobacteria,42TAB@68525|delta/epsilon subdivisions,2WPXY@28221|Deltaproteobacteria,2MA72@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	lolA	-	-	ko:K03634	-	-	-	-	ko00000	-	-	-	LolA
k59_1385513_2	1218076.BAYB01000019_gene3606	4.4e-15	77.0	COG4292@1|root,COG4292@2|Bacteria,1MW5F@1224|Proteobacteria,2VMW0@28216|Betaproteobacteria,1K4R6@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Bacterial low temperature requirement A protein (LtrA)	ltrA	-	-	-	-	-	-	-	-	-	-	-	LtrA
k59_330058_1	671143.DAMO_2528	4.47e-61	199.0	COG2177@1|root,COG2177@2|Bacteria,2NPIM@2323|unclassified Bacteria	2|Bacteria	D	Belongs to the ABC-4 integral membrane protein family. FtsX subfamily	ftsX	GO:0000910,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006928,GO:0007049,GO:0007154,GO:0007165,GO:0007166,GO:0008150,GO:0008356,GO:0009274,GO:0009276,GO:0009605,GO:0009607,GO:0009615,GO:0009966,GO:0009987,GO:0010033,GO:0010646,GO:0016020,GO:0016021,GO:0016043,GO:0019221,GO:0022402,GO:0022603,GO:0022607,GO:0023051,GO:0023052,GO:0030312,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0032153,GO:0032506,GO:0034097,GO:0040007,GO:0040011,GO:0042173,GO:0042221,GO:0043207,GO:0043937,GO:0043938,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0045595,GO:0045597,GO:0045881,GO:0048518,GO:0048522,GO:0048583,GO:0048870,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051094,GO:0051179,GO:0051301,GO:0051674,GO:0051704,GO:0051707,GO:0051716,GO:0065007,GO:0070098,GO:0070297,GO:0070887,GO:0071310,GO:0071345,GO:0071840,GO:0071944,GO:0071976,GO:0090529,GO:1902531	-	ko:K09811,ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	FtsX
k59_719142_1	83406.HDN1F_08650	1.06e-36	142.0	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,1RM9X@1236|Gammaproteobacteria,1J4HS@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019538,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034645,GO:0036094,GO:0043021,GO:0043024,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0097159,GO:0097216,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc
k59_1548561_1	1122179.KB890447_gene255	1.14e-88	292.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,4NGU2@976|Bacteroidetes,1IWHI@117747|Sphingobacteriia	976|Bacteroidetes	M	Tricorn protease PDZ domain	-	-	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
k59_1497070_1	589924.Ferp_0096	1.65e-74	246.0	COG1055@1|root,arCOG00238@2157|Archaea,2XTRK@28890|Euryarchaeota,245XT@183980|Archaeoglobi	183980|Archaeoglobi	P	Sodium:sulfate symporter transmembrane region	-	-	-	ko:K14445	-	-	-	-	ko00000,ko02000	2.A.47.1	-	-	Na_sulph_symp
k59_1331140_1	113395.AXAI01000004_gene4585	1.12e-81	258.0	COG2368@1|root,COG2368@2|Bacteria,1PEQG@1224|Proteobacteria,2TVQ7@28211|Alphaproteobacteria,3JWEV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	4-hydroxyphenylacetate 3-hydroxylase C terminal	-	-	-	-	-	-	-	-	-	-	-	-	HpaB,HpaB_N
k59_438545_1	324057.Pjdr2_3329	4.05e-20	92.8	COG1680@1|root,COG1680@2|Bacteria,1V3KP@1239|Firmicutes,4HJ26@91061|Bacilli,275GP@186822|Paenibacillaceae	91061|Bacilli	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_105026_1	1123037.AUDE01000027_gene2129	2.98e-117	350.0	COG0504@1|root,COG0504@2|Bacteria,4NEWT@976|Bacteroidetes,1HWP2@117743|Flavobacteriia	976|Bacteroidetes	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
k59_160686_1	864069.MicloDRAFT_00017780	8.67e-45	154.0	COG1451@1|root,COG1451@2|Bacteria,1MXZU@1224|Proteobacteria,2U1JG@28211|Alphaproteobacteria,1JR8H@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Protein of unknown function DUF45	MA20_23375	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF45
k59_160686_2	1121020.JIAG01000003_gene2588	8.46e-14	72.0	COG0477@1|root,COG2814@2|Bacteria,2GJK6@201174|Actinobacteria,1W8RH@1268|Micrococcaceae	201174|Actinobacteria	EGP	drug resistance transporter, Bcr CflA subfamily	-	-	-	ko:K07552	-	-	-	-	ko00000,ko02000	2.A.1.2	-	-	MFS_1
k59_1331165_1	1047013.AQSP01000099_gene1509	1.84e-34	134.0	COG2234@1|root,COG2234@2|Bacteria,2NRCG@2323|unclassified Bacteria	2|Bacteria	E	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
k59_829777_1	1198232.CYCME_1573	3.14e-12	66.6	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,1RP0K@1236|Gammaproteobacteria,4602D@72273|Thiotrichales	72273|Thiotrichales	L	DNA polymerase III alpha subunit	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_829777_2	272560.BPSL2145	1.25e-34	125.0	COG0164@1|root,COG0164@2|Bacteria,1RA65@1224|Proteobacteria,2VQ06@28216|Betaproteobacteria,1K02A@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	-	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
k59_605365_1	1041142.ATTP01000029_gene4845	2.33e-38	143.0	COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,2TTYY@28211|Alphaproteobacteria,4BAXH@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Zn-dependent alcohol dehydrogenases	adhA	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_1774483_1	861299.J421_0296	9.56e-23	97.8	COG3386@1|root,COG3386@2|Bacteria	2|Bacteria	G	gluconolactonase activity	-	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	SGL
k59_551045_1	861299.J421_2272	7.38e-21	92.8	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_551045_2	861299.J421_2271	3.59e-48	155.0	COG1695@1|root,COG1695@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	-	-	-	-	-	-	-	-	-	PadR
k59_789349_3	1382306.JNIM01000001_gene3774	7.56e-10	58.9	COG1181@1|root,COG1181@2|Bacteria,2G5RS@200795|Chloroflexi	200795|Chloroflexi	F	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
k59_288926_1	1121889.AUDM01000004_gene2537	4.38e-29	113.0	COG1853@1|root,COG1853@2|Bacteria,4NF4H@976|Bacteroidetes,1HWZA@117743|Flavobacteriia,2NTVI@237|Flavobacterium	976|Bacteroidetes	S	Flavin reductase like domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
k59_733914_1	1125863.JAFN01000001_gene1809	1.36e-142	430.0	COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,42MRQ@68525|delta/epsilon subdivisions,2WJ3E@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	iAF987.Gmet_2300	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
k59_1678526_1	861299.J421_3663	1.02e-94	291.0	COG1228@1|root,COG1228@2|Bacteria,1ZSU7@142182|Gemmatimonadetes	142182|Gemmatimonadetes	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_1734061_1	926569.ANT_06710	2.7e-55	191.0	COG1178@1|root,COG1178@2|Bacteria,2G63A@200795|Chloroflexi	200795|Chloroflexi	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02063	ko02010,map02010	M00191	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.19	-	-	BPD_transp_1
k59_1067125_1	1123073.KB899242_gene947	1.07e-42	148.0	COG1273@1|root,COG1273@2|Bacteria,1N4UX@1224|Proteobacteria,1RNJ7@1236|Gammaproteobacteria,1X3MS@135614|Xanthomonadales	135614|Xanthomonadales	L	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD	ku	-	-	ko:K10979	ko03450,map03450	-	-	-	ko00000,ko00001,ko03400	-	-	-	Ku
k59_1178360_1	864069.MicloDRAFT_00065930	4.14e-21	92.0	COG0673@1|root,COG0673@2|Bacteria,1MZIG@1224|Proteobacteria,2U06F@28211|Alphaproteobacteria,1JSQC@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	socC	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_1178360_2	1238182.C882_4426	1.32e-22	91.7	COG0071@1|root,COG0071@2|Bacteria,1R9Y1@1224|Proteobacteria,2UA1J@28211|Alphaproteobacteria,2JSTN@204441|Rhodospirillales	204441|Rhodospirillales	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	-	-	-	-	-	-	-	-	-	HSP20
k59_1289394_2	861299.J421_3278	2.31e-16	77.4	COG0074@1|root,COG0074@2|Bacteria,1ZT20@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
k59_622053_1	56780.SYN_02956	2.02e-63	214.0	COG2202@1|root,COG2203@1|root,COG3829@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42MEA@68525|delta/epsilon subdivisions,2WIW6@28221|Deltaproteobacteria,2MR33@213462|Syntrophobacterales	28221|Deltaproteobacteria	KT	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	GAF,HTH_8,PAS,PAS_3,PAS_4,PAS_9,Sigma54_activat
k59_1011830_1	1297570.MESS4_130016	6.8e-41	148.0	COG0111@1|root,COG0111@2|Bacteria,1MW1U@1224|Proteobacteria,2VFXC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EH	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_1400683_1	886293.Sinac_3820	1.25e-21	92.4	COG2141@1|root,COG2141@2|Bacteria,2J10P@203682|Planctomycetes	203682|Planctomycetes	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_1400683_2	886293.Sinac_3820	2.7e-43	151.0	COG2141@1|root,COG2141@2|Bacteria,2J10P@203682|Planctomycetes	203682|Planctomycetes	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_1235132_1	1293054.HSACCH_00677	5.06e-75	239.0	COG0004@1|root,COG0004@2|Bacteria,1TQYG@1239|Firmicutes,247W1@186801|Clostridia,3WBKG@53433|Halanaerobiales	186801|Clostridia	P	Ammonium Transporter Family	amt	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp,P-II
k59_844382_1	926569.ANT_29200	2.51e-67	225.0	COG4412@1|root,COG4412@2|Bacteria,2G622@200795|Chloroflexi	200795|Chloroflexi	S	Immune inhibitor A peptidase M6	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M6
k59_1567565_2	1415755.JQLV01000001_gene2289	7.86e-08	55.1	COG0664@1|root,COG0664@2|Bacteria,1PIN3@1224|Proteobacteria	1224|Proteobacteria	K	COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
k59_1622625_1	479434.Sthe_3401	2.25e-24	102.0	COG0664@1|root,COG0664@2|Bacteria,2G6WI@200795|Chloroflexi	200795|Chloroflexi	K	PFAM Cyclic nucleotide-binding	-	-	-	ko:K10914,ko:K21564	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
k59_1289436_1	83406.HDN1F_16020	2.23e-112	336.0	COG2301@1|root,COG2301@2|Bacteria,1R7U2@1224|Proteobacteria	1224|Proteobacteria	G	Belongs to the HpcH HpaI aldolase family	-	-	-	-	-	-	-	-	-	-	-	-	HpcH_HpaI
k59_1011861_2	1121930.AQXG01000002_gene1894	5.36e-17	86.3	COG2244@1|root,COG2244@2|Bacteria,4NFKD@976|Bacteroidetes,1IR3Z@117747|Sphingobacteriia	976|Bacteroidetes	S	Polysaccharide biosynthesis protein	wzxC	-	-	ko:K03328,ko:K16695	-	-	-	-	ko00000,ko02000	2.A.66.2,2.A.66.2.7	-	-	Polysacc_synt_3,Polysacc_synt_C
k59_11002_1	1499967.BAYZ01000158_gene436	1.02e-12	67.0	COG1664@1|root,COG1664@2|Bacteria,2NQ1N@2323|unclassified Bacteria	2|Bacteria	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
k59_11002_2	1392540.P256_01584	7.27e-21	89.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,1RMIR@1236|Gammaproteobacteria,3NKBI@468|Moraxellaceae	1236|Gammaproteobacteria	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_1567600_1	7176.CPIJ009805-PA	3.23e-14	70.1	COG1437@1|root,KOG2589@2759|Eukaryota,3A4QC@33154|Opisthokonta,3BRFI@33208|Metazoa,3D8WI@33213|Bilateria,420AD@6656|Arthropoda,3SZ4Y@50557|Insecta,458MR@7147|Diptera,45IKC@7148|Nematocera	33208|Metazoa	F	CYTH	-	-	-	-	-	-	-	-	-	-	-	-	CYTH
k59_177472_1	1229205.BUPH_08531	1.01e-86	280.0	COG4584@1|root,COG4584@2|Bacteria,1MW5J@1224|Proteobacteria,2VMZS@28216|Betaproteobacteria,1K35W@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Evidence 2b Function of strongly homologous gene	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_844423_1	215803.DB30_0881	7.7e-09	58.9	COG1404@1|root,COG4412@1|root,COG1404@2|Bacteria,COG4412@2|Bacteria,1REF1@1224|Proteobacteria,42Q4N@68525|delta/epsilon subdivisions,2WS51@28221|Deltaproteobacteria,2YWNR@29|Myxococcales	28221|Deltaproteobacteria	O	Fibronectin type 3 domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M6,Peptidase_S8
k59_789437_1	868131.MSWAN_1557	0.000152	47.8	COG0842@1|root,arCOG01463@2157|Archaea,2Y34U@28890|Euryarchaeota,23PDD@183925|Methanobacteria	183925|Methanobacteria	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
k59_1178437_1	1121948.AUAC01000008_gene823	3.04e-77	248.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria,43X4S@69657|Hyphomonadaceae	28211|Alphaproteobacteria	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
k59_400084_1	300852.55773097	6.29e-70	225.0	COG0668@1|root,COG0668@2|Bacteria,1WJII@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	mechanosensitive ion channel	-	-	-	ko:K22044	-	-	-	-	ko00000,ko02000	1.A.23.3	-	-	MS_channel
k59_1622670_1	1211112.ALJC01000120_gene584	1.05e-09	63.5	COG4137@1|root,COG4137@2|Bacteria,1R3YD@1224|Proteobacteria,1RPUQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	cytochrome C assembly protein	ypjD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
k59_789452_1	771875.Ferpe_1130	4.75e-27	114.0	COG1253@1|root,COG1253@2|Bacteria,2GCB4@200918|Thermotogae	200918|Thermotogae	S	PFAM CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
k59_1123376_1	1452718.JBOY01000142_gene1500	6.45e-46	157.0	COG1788@1|root,COG1788@2|Bacteria,1MVEI@1224|Proteobacteria,1RNXB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	COG1788 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit	scoA	-	2.8.3.5	ko:K01028	ko00072,ko00280,ko00650,map00072,map00280,map00650	-	R00410	RC00014	ko00000,ko00001,ko01000	-	-	iJN746.PP_3122	CoA_trans
k59_121788_2	1211115.ALIQ01000002_gene4358	1.97e-28	108.0	COG3707@1|root,COG3707@2|Bacteria,1MXDV@1224|Proteobacteria,2U220@28211|Alphaproteobacteria,3NB3Y@45404|Beijerinckiaceae	28211|Alphaproteobacteria	T	ANTAR	nasT	-	-	ko:K07183	-	-	-	-	ko00000,ko02022	-	-	-	ANTAR,Response_reg
k59_233486_1	903818.KI912268_gene2119	2.29e-40	146.0	COG0702@1|root,COG0702@2|Bacteria,3Y8PQ@57723|Acidobacteria	57723|Acidobacteria	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	NmrA
k59_1678631_1	671143.DAMO_2295	2.08e-34	127.0	COG0812@1|root,COG0812@2|Bacteria,2NPHQ@2323|unclassified Bacteria	2|Bacteria	M	Cell wall formation	murB	GO:0000166,GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008360,GO:0008762,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016043,GO:0016491,GO:0016614,GO:0016616,GO:0022603,GO:0022604,GO:0030203,GO:0034645,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045229,GO:0048037,GO:0050660,GO:0050662,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0055114,GO:0065007,GO:0065008,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576	1.3.1.98,6.3.2.4	ko:K00075,ko:K01921	ko00473,ko00520,ko00550,ko01100,ko01502,map00473,map00520,map00550,map01100,map01502	-	R01150,R03191,R03192	RC00064,RC00141,RC02639	ko00000,ko00001,ko01000,ko01011	-	-	iECED1_1282.ECED1_4683,iECUMN_1333.ECUMN_4498_AT6,iIT341.HP1418,iLF82_1304.LF82_1416,iNRG857_1313.NRG857_19845,iYO844.BSU15230	FAD_binding_4,MurB_C
k59_1456773_1	215803.DB30_1821	3.11e-36	137.0	COG0076@1|root,COG0076@2|Bacteria,1MWUX@1224|Proteobacteria,42MYA@68525|delta/epsilon subdivisions,2WKFB@28221|Deltaproteobacteria,2YUKP@29|Myxococcales	28221|Deltaproteobacteria	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	4.1.1.105,4.1.1.28	ko:K01593	ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00037,M00042	R00685,R00699,R00736,R02080,R02701,R04909	RC00299	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyridoxal_deC
k59_1678656_1	631454.N177_1014	2.47e-66	224.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria,1JPM8@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_455934_1	1123508.JH636440_gene2519	4.1e-40	147.0	COG0464@1|root,COG0464@2|Bacteria,2IXNW@203682|Planctomycetes	203682|Planctomycetes	O	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1400779_1	1210884.HG799465_gene12055	2.89e-69	224.0	COG2308@1|root,COG2308@2|Bacteria	2|Bacteria	S	glutamate-cysteine ligase activity	-	-	2.6.1.76	ko:K00836	ko00260,ko01100,ko01120,ko01210,ko01230,map00260,map01100,map01120,map01210,map01230	M00033	R06977	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	CP_ATPgrasp_2,GSP_synth
k59_233520_1	882082.SaccyDRAFT_1283	1.02e-25	110.0	COG2132@1|root,COG2132@2|Bacteria,2GMJ4@201174|Actinobacteria,4DXHW@85010|Pseudonocardiales	201174|Actinobacteria	Q	PFAM Multicopper oxidase	-	-	-	ko:K04753	-	-	-	-	ko00000	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
k59_1512039_1	2045.KR76_20920	3.03e-57	202.0	COG1506@1|root,COG1506@2|Bacteria,2GJ6A@201174|Actinobacteria,4DN13@85009|Propionibacteriales	201174|Actinobacteria	E	Dipeptidyl peptidase IV (DPP IV) N-terminal region	-	-	3.4.14.5	ko:K01278	ko04974,map04974	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	DPPIV_N,Peptidase_S9
k59_1400796_1	926569.ANT_15080	4.61e-35	134.0	COG1572@1|root,COG1572@2|Bacteria,2G9M8@200795|Chloroflexi	2|Bacteria	S	Ig-like domain from next to BRCA1 gene	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,N_BRCA1_IG
k59_511171_1	926569.ANT_18230	5.88e-71	231.0	COG0649@1|root,COG0852@1|root,COG0649@2|Bacteria,COG0852@2|Bacteria,2G5JF@200795|Chloroflexi	200795|Chloroflexi	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	-	1.6.5.3	ko:K00333,ko:K13378	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa,Complex1_49kDa
k59_11113_1	457421.CBFG_01101	1.19e-22	99.0	COG1319@1|root,COG1319@2|Bacteria,1TQA5@1239|Firmicutes,248WI@186801|Clostridia	186801|Clostridia	C	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
k59_1235259_1	877418.ATWV01000010_gene211	9.82e-29	120.0	COG0593@1|root,COG0593@2|Bacteria,2J5F6@203691|Spirochaetes	203691|Spirochaetes	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
k59_289108_1	448385.sce7486	3.74e-27	103.0	COG3682@1|root,COG3682@2|Bacteria,1N3MZ@1224|Proteobacteria	1224|Proteobacteria	K	Penicillinase repressor	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
k59_455971_1	1121346.KB899848_gene195	2.57e-55	192.0	COG1643@1|root,COG1643@2|Bacteria,1TPET@1239|Firmicutes,4HE8W@91061|Bacilli,26U7B@186822|Paenibacillaceae	91061|Bacilli	L	ATP-dependent helicase	hrpB	-	3.6.4.13	ko:K03579	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HA2,Helicase_C,HrpB_C
k59_734106_1	1502852.FG94_04453	1.31e-06	48.9	COG1266@1|root,COG1266@2|Bacteria,1RJZQ@1224|Proteobacteria,2VSUQ@28216|Betaproteobacteria,476YQ@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
k59_1123457_1	768671.ThimaDRAFT_3317	7.07e-70	222.0	COG0604@1|root,COG0604@2|Bacteria,1MV3W@1224|Proteobacteria,1RMHG@1236|Gammaproteobacteria,1WX3U@135613|Chromatiales	135613|Chromatiales	C	PFAM Alcohol dehydrogenase	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_1178532_1	414684.RC1_3063	5.41e-82	254.0	COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,2TSRZ@28211|Alphaproteobacteria,2JQAW@204441|Rhodospirillales	204441|Rhodospirillales	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
k59_1289571_1	1031711.RSPO_c02652	5.37e-20	90.5	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,2VH6S@28216|Betaproteobacteria,1K0U6@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribB	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
k59_177584_1	1120746.CCNL01000010_gene1161	4.54e-14	72.0	COG1063@1|root,COG1063@2|Bacteria	2|Bacteria	E	alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
k59_1123464_1	671143.DAMO_2292	1.74e-94	287.0	COG0206@1|root,COG0206@2|Bacteria,2NNSU@2323|unclassified Bacteria	2|Bacteria	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
k59_1123464_2	1144275.COCOR_06090	8.89e-54	182.0	COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,42MS2@68525|delta/epsilon subdivisions,2WIQ0@28221|Deltaproteobacteria,2YTZH@29|Myxococcales	28221|Deltaproteobacteria	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
k59_345553_1	269799.Gmet_0193	5.54e-57	186.0	COG1691@1|root,COG1691@2|Bacteria,1REQ7@1224|Proteobacteria,42MJG@68525|delta/epsilon subdivisions,2WN0G@28221|Deltaproteobacteria,43U0V@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	AIR carboxylase	-	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
k59_1013439_1	1234364.AMSF01000016_gene1691	6.14e-13	69.3	COG3134@1|root,COG3134@2|Bacteria,1MVWD@1224|Proteobacteria,1RQR9@1236|Gammaproteobacteria,1X4BG@135614|Xanthomonadales	135614|Xanthomonadales	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	Rick_17kDa_Anti
k59_457433_1	251229.Chro_4720	7.07e-20	94.4	COG2159@1|root,COG2159@2|Bacteria,1G3DV@1117|Cyanobacteria,3VKKA@52604|Pleurocapsales	1117|Cyanobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
k59_1569059_1	1197477.IA57_11075	1.91e-18	90.1	COG2885@1|root,COG3209@1|root,COG3227@1|root,COG3291@1|root,COG3391@1|root,COG5184@1|root,COG5563@1|root,COG2885@2|Bacteria,COG3209@2|Bacteria,COG3227@2|Bacteria,COG3291@2|Bacteria,COG3391@2|Bacteria,COG5184@2|Bacteria,COG5563@2|Bacteria,4PMAH@976|Bacteroidetes,1I2AU@117743|Flavobacteriia	976|Bacteroidetes	M	regulator of chromosome condensation, RCC1	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1290886_1	1121447.JONL01000001_gene1092	9.77e-35	133.0	COG0659@1|root,COG0659@2|Bacteria,1MX1U@1224|Proteobacteria,42Q8Y@68525|delta/epsilon subdivisions,2WK07@28221|Deltaproteobacteria,2M9WF@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	PFAM Sulphate transporter	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	MFS_MOT1
k59_1513344_1	485913.Krac_12358	2.21e-50	167.0	COG1666@1|root,COG1666@2|Bacteria,2G6TD@200795|Chloroflexi	200795|Chloroflexi	S	Belongs to the UPF0234 family	-	-	-	ko:K09767	-	-	-	-	ko00000	-	-	-	DUF520
k59_123154_1	330214.NIDE3406	2.15e-88	275.0	COG0129@1|root,COG0129@2|Bacteria,3J0ES@40117|Nitrospirae	40117|Nitrospirae	EG	Dehydratase family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
k59_1735612_1	1380394.JADL01000001_gene2324	1.14e-29	121.0	COG2911@1|root,COG2911@2|Bacteria,1N08J@1224|Proteobacteria,2UE2C@28211|Alphaproteobacteria,2JS6H@204441|Rhodospirillales	204441|Rhodospirillales	S	Dicarboxylate transport	-	-	-	-	-	-	-	-	-	-	-	-	DctA-YdbH
k59_1124868_1	504472.Slin_1254	1.44e-60	201.0	COG2382@1|root,COG2382@2|Bacteria,4NFVV@976|Bacteroidetes,47PFY@768503|Cytophagia	976|Bacteroidetes	P	Belongs to the glycosyl hydrolase 13 family	-	-	-	ko:K07214	-	-	-	-	ko00000	-	-	-	AMPK1_CBM,CBM_48,Esterase
k59_568017_1	1089553.Tph_c17650	1.62e-85	269.0	COG0008@1|root,COG1384@1|root,COG0008@2|Bacteria,COG1384@2|Bacteria,1TPJC@1239|Firmicutes,2482P@186801|Clostridia,42ETH@68295|Thermoanaerobacterales	186801|Clostridia	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
k59_1290910_1	1283299.AUKG01000004_gene1206	1.17e-70	226.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,4CPPT@84995|Rubrobacteria	84995|Rubrobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
k59_1124884_1	631362.Thi970DRAFT_02379	4.23e-12	70.9	COG2367@1|root,COG2367@2|Bacteria,1R7HB@1224|Proteobacteria,1S1BH@1236|Gammaproteobacteria,1WWWC@135613|Chromatiales	135613|Chromatiales	V	Beta-lactamase enzyme family	-	-	3.5.2.6	ko:K17836	ko00311,ko01130,ko01501,map00311,map01130,map01501	M00627,M00628	R06363	RC01499	ko00000,ko00001,ko00002,ko01000,ko01504	-	-	-	Beta-lactamase2
k59_1527655_1	1246459.KB898354_gene4610	1.07e-05	50.8	COG0438@1|root,COG1215@1|root,COG0438@2|Bacteria,COG1215@2|Bacteria,1NDPE@1224|Proteobacteria,2TSCT@28211|Alphaproteobacteria,4B7N8@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	Succinoglycan biosynthesis protein	exoA	-	-	ko:K16557	-	-	-	-	ko00000,ko01000,ko01003	-	GT2	-	Glycos_transf_2
k59_1527655_2	177439.DP1886	0.000783	42.4	COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,42NB5@68525|delta/epsilon subdivisions,2WJGX@28221|Deltaproteobacteria,2MI1J@213118|Desulfobacterales	28221|Deltaproteobacteria	T	histidine kinase HAMP region domain protein	phoR	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8,sCache_like
k59_26820_1	861299.J421_2768	8.29e-92	299.0	COG0086@1|root,COG0086@2|Bacteria,1ZSZQ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_805116_1	998088.B565_3805	1.67e-18	81.6	COG0041@1|root,COG0041@2|Bacteria,1RCWJ@1224|Proteobacteria,1S3VN@1236|Gammaproteobacteria,1Y48K@135624|Aeromonadales	135624|Aeromonadales	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	-	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
k59_805116_2	880073.Calab_1785	2.82e-13	69.3	COG0709@1|root,COG1104@1|root,COG0709@2|Bacteria,COG1104@2|Bacteria,2NNVR@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine	selD	-	2.7.9.3,2.8.1.7	ko:K01008,ko:K04487	ko00450,ko00730,ko01100,ko04122,map00450,map00730,map01100,map04122	-	R03595,R07460,R11528,R11529	RC00002,RC01789,RC02313,RC02878	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	AIRS,AIRS_C,Aminotran_5
k59_305076_1	521045.Kole_2088	2.02e-117	356.0	COG1001@1|root,COG1001@2|Bacteria,2GC3B@200918|Thermotogae	200918|Thermotogae	F	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family	ade	-	3.5.4.2	ko:K01486	ko00230,ko01100,map00230,map01100	-	R01244	RC00477	ko00000,ko00001,ko01000	-	-	-	Adenine_deam_C,Amidohydro_1
k59_972546_1	416591.Tlet_0348	1.65e-75	247.0	COG0143@1|root,COG0143@2|Bacteria,2GCDP@200918|Thermotogae	200918|Thermotogae	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	GO:0003674,GO:0003824,GO:0004812,GO:0004825,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006431,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
k59_859394_1	357808.RoseRS_3926	2.27e-69	224.0	COG0160@1|root,COG0160@2|Bacteria,2G5SK@200795|Chloroflexi,377Z7@32061|Chloroflexia	32061|Chloroflexia	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.19	ko:K00823	ko00250,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_972548_1	671143.DAMO_2345	2.46e-49	167.0	COG0451@1|root,COG0451@2|Bacteria,2NNT0@2323|unclassified Bacteria	2|Bacteria	M	Polysaccharide biosynthesis protein	lspL	-	5.1.3.6	ko:K08679	ko00520,ko01100,map00520,map01100	-	R01385	RC00289	ko00000,ko00001,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
k59_248732_1	240015.ACP_1793	8.56e-67	229.0	COG0210@1|root,COG0210@2|Bacteria,3Y2W8@57723|Acidobacteria,2JIDH@204432|Acidobacteriia	204432|Acidobacteriia	L	PFAM UvrD REP helicase	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_694579_1	1380394.JADL01000009_gene3273	5.02e-85	275.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,2TRGN@28211|Alphaproteobacteria,2JQAY@204441|Rhodospirillales	204441|Rhodospirillales	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom
k59_581901_1	649638.Trad_2243	5.27e-35	138.0	COG0204@1|root,COG2324@1|root,COG0204@2|Bacteria,COG2324@2|Bacteria,1WI4U@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	TIGRFAM lycopene cyclase domain	-	-	5.5.1.19	ko:K22502	ko00906,map00906	-	R03824,R05341	RC01004	ko00000,ko00001,ko01000	-	-	-	Caroten_synth
k59_1695305_1	1321778.HMPREF1982_01822	3.69e-28	116.0	COG3437@1|root,COG3829@1|root,COG3437@2|Bacteria,COG3829@2|Bacteria,1TQ0S@1239|Firmicutes,24800@186801|Clostridia	186801|Clostridia	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GGDEF,HD,HD_5,PAS,PAS_3,PAS_9
k59_637330_1	379066.GAU_0076	5.12e-125	366.0	COG1131@1|root,COG1131@2|Bacteria,1ZUJT@142182|Gemmatimonadetes	2|Bacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1361245_2	1028806.GGE_1755	1.69e-29	110.0	2DIKB@1|root,32UB7@2|Bacteria,1RJ8W@1224|Proteobacteria,1SR5J@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	TIR_2
k59_749479_1	313596.RB2501_00456	1.66e-78	246.0	COG2234@1|root,COG2234@2|Bacteria,4NENF@976|Bacteroidetes,1HX25@117743|Flavobacteriia	976|Bacteroidetes	S	Peptidase m28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28,fn3
k59_749479_2	313596.RB2501_00451	4.62e-11	61.2	COG3548@1|root,COG3548@2|Bacteria,4NW8Z@976|Bacteroidetes	976|Bacteroidetes	S	Protein of unknown function (DUF1211)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1211
k59_972568_1	1408444.JHYC01000021_gene27	1.89e-27	111.0	COG0508@1|root,COG0508@2|Bacteria,1MVDC@1224|Proteobacteria,1RQ9Y@1236|Gammaproteobacteria,1JCDN@118969|Legionellales	118969|Legionellales	C	e3 binding domain	odp	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_415939_1	234267.Acid_3236	9.64e-83	265.0	COG2010@1|root,COG4993@1|root,COG2010@2|Bacteria,COG4993@2|Bacteria	2|Bacteria	G	Dehydrogenase	-	-	1.1.5.2	ko:K00117	ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130	-	R06620	RC00066	ko00000,ko00001,ko01000	-	-	-	Cytochrome_CBB3,PQQ,PQQ_2
k59_82378_1	211586.SO_0055	7.42e-09	59.7	COG0457@1|root,COG0846@1|root,COG0457@2|Bacteria,COG0846@2|Bacteria,1N8F5@1224|Proteobacteria	1224|Proteobacteria	K	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1028918_1	1379270.AUXF01000007_gene934	1.03e-36	137.0	COG0021@1|root,COG0021@2|Bacteria,1ZTA2@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Transketolase, thiamine diphosphate binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
k59_1028918_2	518766.Rmar_0466	1.31e-09	58.5	COG1609@1|root,COG1609@2|Bacteria,4NDW6@976|Bacteroidetes,1FJY2@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	K	PFAM periplasmic binding protein LacI transcriptional regulator	-	-	-	ko:K02529,ko:K05499	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_1,Peripla_BP_3
k59_472963_1	991905.SL003B_2748	8.75e-82	259.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1MU9U@1224|Proteobacteria,2TRAU@28211|Alphaproteobacteria,4BPM2@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.1.5,6.3.5.1	ko:K01916,ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00189,R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
k59_1416498_2	667014.Thein_1327	2.34e-29	122.0	COG0768@1|root,COG0768@2|Bacteria,2GHBT@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	M	Penicillin-binding Protein dimerisation domain	-	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
k59_637368_1	945713.IALB_2173	3.39e-13	74.3	COG2374@1|root,COG2374@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,Gram_pos_anchor,LTD,SLH
k59_918051_1	1379270.AUXF01000004_gene3232	1.63e-23	100.0	COG2204@1|root,COG2204@2|Bacteria,1ZSW0@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1305876_2	472759.Nhal_1233	1.99e-47	158.0	COG0491@1|root,COG0491@2|Bacteria,1MU8Q@1224|Proteobacteria,1S22I@1236|Gammaproteobacteria,1WWHZ@135613|Chromatiales	135613|Chromatiales	S	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	gloB	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	HAGH_C,Lactamase_B
k59_972615_1	1459636.NTE_01631	5.02e-99	308.0	COG1042@1|root,arCOG01338@2157|Archaea,arCOG01340@2157|Archaea,41S7I@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Succinyl-CoA ligase like flavodoxin domain	-	-	-	ko:K18594	ko00720,ko01120,map00720,map01120	-	R03157	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
k59_749527_1	330214.NIDE1868	7.92e-111	350.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,3J0UH@40117|Nitrospirae	40117|Nitrospirae	H	Pterin binding enzyme	-	-	2.1.1.13,2.1.1.258	ko:K00548,ko:K15023	ko00270,ko00450,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01230,map00270,map00450,map00670,map00720,map01100,map01110,map01120,map01200,map01230	M00017,M00377	R00946,R02289,R09365,R10243	RC00004,RC00035,RC00113,RC01144,RC01241,RC02871,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Pterin_bind,S-methyl_trans
k59_26909_1	3055.EDO96374	1.94e-42	157.0	28K1M@1|root,2QSG2@2759|Eukaryota,382J6@33090|Viridiplantae,34NRG@3041|Chlorophyta	3041|Chlorophyta	F	D-ala D-ala ligase C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	Dala_Dala_lig_C
k59_1749476_1	691883.XP_009493824.1	1.53e-70	240.0	COG0265@1|root,KOG1421@2759|Eukaryota,39J7H@33154|Opisthokonta	33154|Opisthokonta	O	serine-type endopeptidase activity	nma111	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0006508,GO:0006629,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009987,GO:0016787,GO:0017171,GO:0019538,GO:0043170,GO:0044237,GO:0044238,GO:0044255,GO:0070011,GO:0071704,GO:0140096,GO:1901564	-	-	-	-	-	-	-	-	-	-	PDZ_1,PDZ_2,Trypsin_2
k59_1028963_1	1123242.JH636436_gene290	5.95e-44	169.0	COG0243@1|root,COG0437@1|root,COG0243@2|Bacteria,COG0437@2|Bacteria,2IXNQ@203682|Planctomycetes	203682|Planctomycetes	C	Molybdopterin oxidoreductase, iron-sulfur binding subunit	-	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_7,Molydop_binding
k59_694671_1	1123060.JONP01000036_gene3546	6.89e-84	271.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2TQVK@28211|Alphaproteobacteria,2JPB3@204441|Rhodospirillales	204441|Rhodospirillales	C	COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL homologs	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C2
k59_1305908_1	519989.ECTPHS_07067	2.29e-41	157.0	COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,1RMUH@1236|Gammaproteobacteria,1WWAH@135613|Chromatiales	135613|Chromatiales	C	TIGRFAM NADH-quinone oxidoreductase, chain G	-	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_473012_1	593907.Celgi_1873	4.62e-56	181.0	COG2141@1|root,COG2141@2|Bacteria,2GPA5@201174|Actinobacteria,4F27Z@85016|Cellulomonadaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_1527771_1	1535422.ND16A_3571	2.94e-91	278.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,1RMAQ@1236|Gammaproteobacteria,2Q707@267889|Colwelliaceae	1236|Gammaproteobacteria	L	Transposase	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_918109_1	1122214.AQWH01000004_gene1072	6.85e-28	116.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria,2PJNC@255475|Aurantimonadaceae	28211|Alphaproteobacteria	G	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_972666_2	591157.SSLG_05988	2.75e-17	74.7	COG3360@1|root,COG3360@2|Bacteria,2IQ6Z@201174|Actinobacteria	201174|Actinobacteria	S	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
k59_582017_1	1380394.JADL01000016_gene428	2.27e-83	260.0	COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,2TSEY@28211|Alphaproteobacteria,2JPY7@204441|Rhodospirillales	204441|Rhodospirillales	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
k59_1305944_1	316274.Haur_4105	1.22e-94	303.0	COG1048@1|root,COG1048@2|Bacteria,2G5NG@200795|Chloroflexi,374T1@32061|Chloroflexia	32061|Chloroflexia	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k59_1083233_1	134676.ACPL_4555	8.78e-14	70.9	COG3595@1|root,COG3595@2|Bacteria,2GJZC@201174|Actinobacteria,4DDXR@85008|Micromonosporales	201174|Actinobacteria	S	Putative adhesin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
k59_1083233_2	1464048.JNZS01000012_gene3418	2.62e-87	265.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4DB3C@85008|Micromonosporales	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_805264_1	745310.G432_00495	1.4e-92	282.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TR78@28211|Alphaproteobacteria,2K0AS@204457|Sphingomonadales	204457|Sphingomonadales	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.12	ko:K14448	ko00630,ko01120,ko01200,map00630,map01120,map01200	M00373	R09293	RC02483	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_1749530_1	518766.Rmar_1601	2.88e-58	199.0	COG1562@1|root,COG2324@1|root,COG1562@2|Bacteria,COG2324@2|Bacteria,4PERW@976|Bacteroidetes,1FJHM@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	I	Squalene/phytoene synthase	-	-	2.5.1.32,2.5.1.99	ko:K02291	ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110	M00097	R02065,R04218,R07270,R10177	RC00362,RC01101,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	SQS_PSY
k59_805269_1	258594.RPA1660	4.25e-15	75.9	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria,3JQNW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	actP	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase,YHS
k59_805269_2	999630.TUZN_1222	9.15e-09	61.2	COG0535@1|root,arCOG00938@2157|Archaea,2XPKT@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM Radical SAM domain protein	-	-	-	ko:K22227	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
k59_1583593_1	926550.CLDAP_32780	1.54e-25	102.0	COG1173@1|root,COG1173@2|Bacteria,2G6HB@200795|Chloroflexi	200795|Chloroflexi	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
k59_1583593_2	926550.CLDAP_32790	5.94e-44	160.0	COG0444@1|root,COG4608@1|root,COG0444@2|Bacteria,COG4608@2|Bacteria,2GBKB@200795|Chloroflexi	200795|Chloroflexi	P	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_749601_1	1274524.BSONL12_19716	4.33e-40	142.0	COG1051@1|root,COG1051@2|Bacteria,1U7WX@1239|Firmicutes,4HHQT@91061|Bacilli,1ZD9E@1386|Bacillus	91061|Bacilli	F	ADP-ribose pyrophosphatase	yjhB	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX,Nudix_N
k59_26975_1	1095750.HMPREF9970_2549	1.79e-28	112.0	COG1214@1|root,COG1214@2|Bacteria,1V4YX@1239|Firmicutes,24A0P@186801|Clostridia,1HVJT@1164882|Lachnoanaerobaculum	186801|Clostridia	O	Glycoprotease family	yeaZ	-	-	ko:K14742	-	-	-	-	ko00000,ko03016	-	-	-	Acetyltransf_1,Peptidase_M22
k59_639088_1	1386089.N865_02950	1.58e-72	234.0	COG1884@1|root,COG1884@2|Bacteria,2GM65@201174|Actinobacteria,4FK0I@85021|Intrasporangiaceae	201174|Actinobacteria	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
k59_1697151_1	626887.J057_13371	3.96e-108	341.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,46425@72275|Alteromonadaceae	1236|Gammaproteobacteria	V	Efflux pump	mexF	-	-	ko:K18138,ko:K18299,ko:K19585	ko01501,ko01503,map01501,map01503	M00641,M00647,M00699,M00718,M00767	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2,2.A.6.2.16,2.A.6.2.47	-	-	ACR_tran
k59_1253359_1	1348583.ATLH01000031_gene1885	1.03e-94	293.0	COG1404@1|root,COG1404@2|Bacteria,4NF1M@976|Bacteroidetes,1HXFD@117743|Flavobacteriia,1F7V0@104264|Cellulophaga	976|Bacteroidetes	M	PFAM Peptidase S8 S53, subtilisin kexin sedolisin	wprA	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
k59_1307857_1	472759.Nhal_1374	9.92e-77	247.0	COG4805@1|root,COG4805@2|Bacteria,1R5EP@1224|Proteobacteria,1RRS6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
k59_639095_2	1459636.NTE_03122	3.88e-52	168.0	COG5496@1|root,arCOG04331@2157|Archaea	2157|Archaea	S	thioesterase	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
k59_417722_1	113395.AXAI01000010_gene2218	0.00029	49.3	28MSC@1|root,2ZB0S@2|Bacteria,1NG2A@1224|Proteobacteria,2U8EJ@28211|Alphaproteobacteria,3K390@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_861154_2	59538.XP_005980120.1	3.08e-31	114.0	COG0251@1|root,KOG2317@2759|Eukaryota	2759|Eukaryota	J	endoribonuclease L-PSP	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	OTCace,OTCace_N,Ribonuc_L-PSP
k59_528932_1	266117.Rxyl_0520	3.91e-62	198.0	COG3415@1|root,COG3415@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_29,HTH_32
k59_1141208_1	83406.HDN1F_05030	2.55e-87	278.0	COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,1RN7H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Peptidase S15	cocE	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
k59_919967_1	379066.GAU_2170	8.97e-51	175.0	COG1078@1|root,COG1078@2|Bacteria,1ZT3F@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06885	-	-	-	-	ko00000	-	-	-	HD
k59_861162_1	1379270.AUXF01000006_gene137	8.12e-11	63.9	COG0772@1|root,COG0772@2|Bacteria,1ZSXM@142182|Gemmatimonadetes	142182|Gemmatimonadetes	D	Cell cycle protein	-	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
k59_861162_2	945713.IALB_1849	1.16e-30	126.0	COG0768@1|root,COG0768@2|Bacteria	2|Bacteria	M	penicillin binding	mrdA	GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042493,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0045229,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:0071972,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	iAF987.Gmet_0928,iEcE24377_1341.EcE24377A_0661,iPC815.YPO2604	PBP_dimer,Transpeptidase
k59_1307892_1	1240349.ANGC01000006_gene1475	1.55e-27	109.0	COG3832@1|root,COG3832@2|Bacteria,2IBWM@201174|Actinobacteria,4G90C@85025|Nocardiaceae	201174|Actinobacteria	J	glyoxalase III activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1085111_2	1298593.TOL_0562	1.53e-53	173.0	COG2010@1|root,COG2010@2|Bacteria,1MW1W@1224|Proteobacteria,1S1DG@1236|Gammaproteobacteria,1XJT3@135619|Oceanospirillales	135619|Oceanospirillales	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
k59_974482_1	379066.GAU_1584	3.94e-72	239.0	COG0542@1|root,COG0542@2|Bacteria,1ZTBV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Clp amino terminal domain, pathogenicity island component	-	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
k59_250537_1	926569.ANT_10890	6.79e-78	236.0	COG2316@1|root,COG2316@2|Bacteria,2G6T2@200795|Chloroflexi	200795|Chloroflexi	S	TIGRFAM metal dependent phophohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HD
k59_1474554_1	1120953.AUBH01000004_gene3093	1.58e-92	281.0	COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,1RNB8@1236|Gammaproteobacteria,464PM@72275|Alteromonadaceae	1236|Gammaproteobacteria	O	COG1404 Subtilisin-like serine proteases	-	-	-	ko:K14645	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	PKD,Peptidase_S8
k59_1639605_1	1235796.C815_01407	5.43e-13	67.8	COG1302@1|root,COG1302@2|Bacteria,1V731@1239|Firmicutes	1239|Firmicutes	S	Protein conserved in bacteria	yloU	-	-	-	-	-	-	-	-	-	-	-	Asp23
k59_1324010_1	335284.Pcryo_0171	5.67e-07	51.6	COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,1RM7N@1236|Gammaproteobacteria,3NJSW@468|Moraxellaceae	1236|Gammaproteobacteria	H	Glutamate-1-semialdehyde aminotransferase	hemL	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016853,GO:0016866,GO:0016869,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042286,GO:0042440,GO:0042802,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iUMNK88_1353.UMNK88_158	Aminotran_3
k59_1324010_2	1122221.JHVI01000010_gene2507	6.7e-16	81.6	COG0642@1|root,COG2205@2|Bacteria,1WM7D@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
k59_598475_1	926569.ANT_30130	3.09e-60	197.0	COG1376@1|root,COG1376@2|Bacteria	2|Bacteria	D	ErfK ybiS ycfS ynhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF5011,YkuD
k59_1046585_1	379066.GAU_1316	2.01e-36	137.0	COG1538@1|root,COG1538@2|Bacteria	2|Bacteria	MU	efflux transmembrane transporter activity	cebC	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_712199_1	452637.Oter_2913	5.8e-77	251.0	COG3420@1|root,COG3420@2|Bacteria,46TGV@74201|Verrucomicrobia,3K8EW@414999|Opitutae	414999|Opitutae	P	Right handed beta helix region	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
k59_1210878_1	316067.Geob_1283	2.89e-20	94.7	COG1361@1|root,COG1404@1|root,COG3210@1|root,COG4625@1|root,COG4886@1|root,COG1361@2|Bacteria,COG1404@2|Bacteria,COG3210@2|Bacteria,COG4625@2|Bacteria,COG4886@2|Bacteria,1QUXB@1224|Proteobacteria	1224|Proteobacteria	U	6-phosphogluconolactonase activity	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter,Cadherin_3,DUF11,DUF4347,He_PIG,PATR
k59_821829_1	518766.Rmar_0424	4.31e-61	211.0	COG0025@1|root,COG0569@1|root,COG1762@1|root,COG0025@2|Bacteria,COG0569@2|Bacteria,COG1762@2|Bacteria,4PKJ5@976|Bacteroidetes,1FIVS@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,TrkA_N
k59_42618_1	1110502.TMO_1843	1.2e-22	100.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2TQRZ@28211|Alphaproteobacteria,2JPRN@204441|Rhodospirillales	204441|Rhodospirillales	S	COG0488 ATPase components of ABC transporters with duplicated ATPase domains	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
k59_543714_1	232721.Ajs_2083	3.63e-43	159.0	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,2VIDE@28216|Betaproteobacteria,4AAN3@80864|Comamonadaceae	28216|Betaproteobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
k59_877016_1	526227.Mesil_2957	9.45e-77	242.0	COG0156@1|root,COG0156@2|Bacteria,1WIXA@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	-	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0008890,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.3.1.29,2.3.1.47	ko:K00639,ko:K00652	ko00260,ko00780,ko01100,map00260,map00780,map01100	M00123,M00573,M00577	R00371,R03210,R10124	RC00004,RC00039,RC00394,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_208277_1	240015.ACP_1268	1.67e-98	316.0	2CDRA@1|root,2Z7QN@2|Bacteria,3Y73N@57723|Acidobacteria,2JMK6@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1600822_1	273068.TTE1998	6.97e-72	234.0	COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia,42F02@68295|Thermoanaerobacterales	186801|Clostridia	K	transcriptional regulator	-	-	-	ko:K06714	-	-	-	-	ko00000,ko03000	-	-	-	FeS,Fe_hyd_lg_C,HTH_8,PAS,PAS_8,PAS_9,PTS-HPr,Sigma54_activat
k59_543735_1	690850.Desaf_1999	2.01e-24	107.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,2M7S1@213115|Desulfovibrionales	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_42649_1	1004785.AMBLS11_01730	6.81e-19	80.5	COG0089@1|root,COG0089@2|Bacteria,1MZXX@1224|Proteobacteria,1S8VX@1236|Gammaproteobacteria,467BY@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
k59_1713216_1	926569.ANT_06520	5.33e-12	64.7	COG1028@1|root,COG1028@2|Bacteria,2G6IK@200795|Chloroflexi	200795|Chloroflexi	IQ	PFAM short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_1713216_2	926569.ANT_06500	4.91e-55	181.0	COG0111@1|root,COG0111@2|Bacteria	2|Bacteria	EH	4-phosphoerythronate dehydrogenase activity	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_1210923_1	861299.J421_0317	9.82e-149	439.0	28JZZ@1|root,2Z9PZ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_490477_1	1121904.ARBP01000024_gene6653	4.68e-12	68.2	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,4NHS5@976|Bacteroidetes,47MWY@768503|Cytophagia	976|Bacteroidetes	EU	Peptidase S9 prolyl oligopeptidase active site domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
k59_1378788_1	1266925.JHVX01000012_gene1692	9.15e-71	235.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2VHAN@28216|Betaproteobacteria,371SH@32003|Nitrosomonadales	28216|Betaproteobacteria	V	ABC transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_877058_1	379066.GAU_0510	4.25e-05	48.5	2DW4B@1|root,33YGG@2|Bacteria,1ZV12@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1543241_1	926692.AZYG01000059_gene137	1.42e-17	87.4	COG0517@1|root,COG0617@1|root,COG0618@1|root,COG0517@2|Bacteria,COG0617@2|Bacteria,COG0618@2|Bacteria,1TQ2A@1239|Firmicutes,247XC@186801|Clostridia,3WARU@53433|Halanaerobiales	186801|Clostridia	J	Belongs to the tRNA nucleotidyltransferase poly(A) polymerase family	cca	-	2.7.7.19,2.7.7.72	ko:K00970,ko:K00974	ko03013,ko03018,map03013,map03018	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	CBS,DHH,DHHA1,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2
k59_821878_1	926569.ANT_27410	3.96e-82	266.0	COG0525@1|root,COG0525@2|Bacteria,2G5VS@200795|Chloroflexi	200795|Chloroflexi	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
k59_990424_1	1227349.C170_25357	3.15e-31	123.0	COG4585@1|root,COG4585@2|Bacteria,1UYVE@1239|Firmicutes,4HGNS@91061|Bacilli,26U39@186822|Paenibacillaceae	91061|Bacilli	T	signal transduction histidine kinase	ydfH	-	2.7.13.3	ko:K11623	ko02020,map02020	M00484	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA_3
k59_1378802_1	1002340.AFCF01000043_gene2045	9.6e-50	159.0	COG2963@1|root,COG2963@2|Bacteria,1RGZ5@1224|Proteobacteria,2UAIS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
k59_1378802_2	388739.RSK20926_15481	1.62e-130	375.0	COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,2P3AF@2433|Roseobacter	28211|Alphaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
k59_99236_1	316274.Haur_4591	3.56e-08	54.3	COG0436@1|root,COG0436@2|Bacteria,2G5MC@200795|Chloroflexi,374TY@32061|Chloroflexia	32061|Chloroflexia	E	aminotransferase class I and II	-	-	-	ko:K10907	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_1378806_1	756067.MicvaDRAFT_1008	2.81e-63	204.0	COG0400@1|root,COG0400@2|Bacteria,1G3RX@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM phospholipase Carboxylesterase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_2,Esterase
k59_543785_1	1122138.AQUZ01000008_gene3738	9.25e-10	61.2	COG0668@1|root,COG0668@2|Bacteria,2HD92@201174|Actinobacteria,4DRXH@85009|Propionibacteriales	201174|Actinobacteria	M	Conserved TM helix	-	-	-	-	-	-	-	-	-	-	-	-	TM_helix
k59_712313_1	1185652.USDA257_c58300	7.98e-158	449.0	COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,2TSRD@28211|Alphaproteobacteria,4B7QX@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
k59_1269460_1	1123366.TH3_10671	4.78e-05	49.7	COG3258@1|root,COG3258@2|Bacteria,1RI0Z@1224|Proteobacteria,2U95H@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG2010 Cytochrome c, mono- and diheme variants	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
k59_1324131_1	383372.Rcas_1195	8.41e-14	73.6	COG1366@1|root,COG2172@1|root,COG1366@2|Bacteria,COG2172@2|Bacteria,2G93H@200795|Chloroflexi,375J3@32061|Chloroflexia	32061|Chloroflexia	T	PFAM Sulfate transporter antisigma-factor antagonist STAS	-	-	2.7.11.1	ko:K04749,ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c_2,STAS
k59_1378842_1	1121405.dsmv_0026	7.23e-27	101.0	COG2050@1|root,COG2050@2|Bacteria,1RBPE@1224|Proteobacteria,42RKY@68525|delta/epsilon subdivisions,2WNSM@28221|Deltaproteobacteria,2MJZR@213118|Desulfobacterales	28221|Deltaproteobacteria	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
k59_1378842_2	1150600.ADIARSV_2874	1.6e-12	73.2	COG3975@1|root,COG3975@2|Bacteria,4NGTY@976|Bacteroidetes,1INM3@117747|Sphingobacteriia	976|Bacteroidetes	S	Peptidase M61	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Peptidase_M61
k59_1433519_1	485913.Krac_12289	9.29e-25	102.0	COG1408@1|root,COG1408@2|Bacteria,2G6VC@200795|Chloroflexi	200795|Chloroflexi	S	PFAM metallophosphoesterase	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos
k59_1433519_2	375451.RD1_3558	6.65e-16	77.8	2C3WA@1|root,2Z8P1@2|Bacteria,1R8VC@1224|Proteobacteria,2U8X3@28211|Alphaproteobacteria,2P4MK@2433|Roseobacter	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1713289_1	1321778.HMPREF1982_01422	8.34e-32	121.0	COG0596@1|root,COG0596@2|Bacteria,1U3PB@1239|Firmicutes,24DR6@186801|Clostridia	186801|Clostridia	S	Hydrolase, alpha beta domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
k59_1713290_1	1227453.C444_10259	4.3e-47	167.0	COG1653@1|root,arCOG00151@2157|Archaea,2Y2AY@28890|Euryarchaeota,23Z4Y@183963|Halobacteria	183963|Halobacteria	G	COG1653 ABC-type sugar transport system, periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_765670_1	926569.ANT_21060	4.94e-66	214.0	COG1058@1|root,COG1058@2|Bacteria,2G6DU@200795|Chloroflexi	200795|Chloroflexi	S	PFAM molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CinA,MoCF_biosynth
k59_1600904_1	1379698.RBG1_1C00001G1545	3.6e-36	138.0	COG0745@1|root,COG0745@2|Bacteria,2NNXK@2323|unclassified Bacteria	2|Bacteria	KT	PglZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PglZ,Response_reg
k59_990480_1	1234664.AMRO01000002_gene2181	1.06e-86	271.0	COG0520@1|root,COG0520@2|Bacteria,1TQWE@1239|Firmicutes,4HCHU@91061|Bacilli,1WEDX@129337|Geobacillus	91061|Bacilli	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
k59_938066_1	290317.Cpha266_0973	1.61e-62	209.0	COG0374@1|root,COG0374@2|Bacteria,1FDHI@1090|Chlorobi	1090|Chlorobi	C	Belongs to the NiFe NiFeSe hydrogenase large subunit family	-	-	1.12.99.6	ko:K06281	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
k59_1767502_2	85643.Tmz1t_2772	2.93e-26	103.0	COG1714@1|root,COG1714@2|Bacteria,1REEC@1224|Proteobacteria,2VRE0@28216|Betaproteobacteria,2KWXJ@206389|Rhodocyclales	206389|Rhodocyclales	S	membrane protein domain	-	-	-	-	-	-	-	-	-	-	-	-	RDD
k59_1212727_1	1203568.HMPREF1484_00875	2.54e-31	120.0	COG0500@1|root,COG2226@2|Bacteria,2HWAV@201174|Actinobacteria,4FBN2@85020|Dermabacteraceae	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_266127_1	391036.EHF_0250	8.57e-18	85.5	COG1612@1|root,COG1612@2|Bacteria,1MVJ4@1224|Proteobacteria,2TR0M@28211|Alphaproteobacteria,47F5S@766|Rickettsiales	766|Rickettsiales	H	Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group	ctaA	-	-	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07412	RC00769	ko00000,ko00001,ko00002,ko03029	3.D.4.4	-	-	COX15-CtaA
k59_1767511_1	391612.CY0110_14003	2.95e-19	86.7	2E3GU@1|root,32YFI@2|Bacteria,1G9HI@1117|Cyanobacteria,3KIKQ@43988|Cyanothece	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_266134_1	278963.ATWD01000001_gene4249	4.16e-05	51.6	COG0308@1|root,COG0308@2|Bacteria,3Y71N@57723|Acidobacteria	57723|Acidobacteria	E	Peptidase family M1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
k59_156256_1	1131814.JAFO01000001_gene3991	6.14e-20	82.0	COG2721@1|root,COG2721@2|Bacteria,1MZBN@1224|Proteobacteria,2UC3F@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	SAF	-	-	4.4.1.24	ko:K16845	ko00270,map00270	-	R07633	RC01785	ko00000,ko00001,ko01000	-	-	-	SAF
k59_156256_2	1231190.NA8A_14926	1.62e-68	218.0	COG2721@1|root,COG2721@2|Bacteria,1MU9V@1224|Proteobacteria,2TTDT@28211|Alphaproteobacteria,43KAZ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	D-galactarate dehydratase / Altronate hydrolase, C terminus	garD	-	4.2.1.7,4.4.1.24	ko:K16846,ko:K16850	ko00040,ko00270,ko01100,map00040,map00270,map01100	M00631	R01540,R07633	RC00543,RC01785	ko00000,ko00001,ko00002,ko01000	-	-	-	GD_AH_C
k59_492688_1	1379698.RBG1_1C00001G0460	1.12e-57	204.0	COG0587@1|root,COG0587@2|Bacteria,2NNVY@2323|unclassified Bacteria	2|Bacteria	L	DNA polymerase	dnaE	GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032991,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0046483,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,RNase_T,tRNA_anti-codon
k59_434340_1	1232410.KI421421_gene3557	3e-20	92.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,43RYA@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Bacterial regulatory protein, Fis family	gnfM	-	-	ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_434340_2	311424.DhcVS_688	1.07e-06	51.2	COG0352@1|root,COG0352@2|Bacteria,2G6P0@200795|Chloroflexi,34D0T@301297|Dehalococcoidia	301297|Dehalococcoidia	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	thiE	-	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
k59_1544915_1	1034769.KB910518_gene3376	1.64e-05	54.3	COG3250@1|root,COG3867@1|root,COG4733@1|root,COG5492@1|root,COG3250@2|Bacteria,COG3867@2|Bacteria,COG4733@2|Bacteria,COG5492@2|Bacteria,1UNMG@1239|Firmicutes,4IUI8@91061|Bacilli,277MP@186822|Paenibacillaceae	91061|Bacilli	GN	Bacterial Ig-like domain (group 2)	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,SLH
k59_714452_1	1183438.GKIL_0015	3.96e-65	218.0	COG0021@1|root,COG0021@2|Bacteria,1G0GC@1117|Cyanobacteria	1117|Cyanobacteria	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tktA	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
k59_1544925_1	1211777.BN77_2771	1.05e-18	90.5	COG4961@1|root,COG4961@2|Bacteria,1QV5Z@1224|Proteobacteria,2TWAQ@28211|Alphaproteobacteria,4BP1W@82115|Rhizobiaceae	28211|Alphaproteobacteria	U	Putative Flp pilus-assembly TadE/G-like	-	-	-	-	-	-	-	-	-	-	-	-	Tad
k59_209994_1	1286106.MPL1_11683	1.1e-33	132.0	COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,1RPFM@1236|Gammaproteobacteria,45ZVU@72273|Thiotrichales	72273|Thiotrichales	M	PFAM AsmA family	-	-	-	ko:K07289	-	-	-	-	ko00000	-	-	-	AsmA
k59_434355_1	1268303.RHODMAR_4157	5.35e-25	106.0	COG0248@1|root,COG0248@2|Bacteria,2GJBN@201174|Actinobacteria,4FW2F@85025|Nocardiaceae	201174|Actinobacteria	FP	Ppx/GppA phosphatase family	ppx2	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
k59_209995_1	1121931.AUHG01000012_gene2556	8.05e-24	102.0	COG3386@1|root,COG3386@2|Bacteria	2|Bacteria	G	gluconolactonase activity	-	-	-	-	-	-	-	-	-	-	-	-	SGL
k59_379191_1	1121918.ARWE01000001_gene3116	2e-116	349.0	COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,42M0J@68525|delta/epsilon subdivisions,2WK1D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
k59_714479_1	926569.ANT_17710	1.33e-76	238.0	COG1216@1|root,COG1216@2|Bacteria,2G961@200795|Chloroflexi	200795|Chloroflexi	H	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_101092_1	1379270.AUXF01000006_gene238	1.08e-26	106.0	COG0839@1|root,COG0839@2|Bacteria,1ZTSA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	NADH-ubiquinone/plastoquinone oxidoreductase chain 6	-	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
k59_101092_2	861299.J421_3287	1.41e-09	56.6	COG1143@1|root,COG1143@2|Bacteria,1ZTHB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4_7
k59_767280_2	1121405.dsmv_0569	3.28e-17	83.6	COG1893@1|root,COG1893@2|Bacteria,1P0AW@1224|Proteobacteria,42QZK@68525|delta/epsilon subdivisions,2WMZB@28221|Deltaproteobacteria,2MMMP@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
k59_492746_1	251229.Chro_2922	1.39e-40	147.0	28IMC@1|root,2Z8MV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_492746_2	370438.PTH_0220	2.04e-10	61.6	COG0413@1|root,COG0413@2|Bacteria,1TPZA@1239|Firmicutes,248RR@186801|Clostridia,260CY@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
k59_714501_1	1004149.AFOE01000006_gene2082	2.54e-74	246.0	COG0726@1|root,COG3250@1|root,COG0726@2|Bacteria,COG3250@2|Bacteria,4NEDP@976|Bacteroidetes,1IMPI@117743|Flavobacteriia	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 2 family	-	-	3.1.1.53	ko:K05970	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_hydro_2_N,SASA
k59_44497_1	1238182.C882_3714	4.66e-88	282.0	COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,2TRUM@28211|Alphaproteobacteria,2JR96@204441|Rhodospirillales	204441|Rhodospirillales	E	aminopeptidase N	pepN	-	3.4.11.2	ko:K01256	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3458,DUF3458_C,Peptidase_M1
k59_600283_1	118166.JH976537_gene398	9.72e-27	110.0	COG1408@1|root,COG1408@2|Bacteria,1GQUH@1117|Cyanobacteria,1HAMV@1150|Oscillatoriales	1117|Cyanobacteria	S	metallophosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1380729_1	1122179.KB890423_gene2365	2.92e-56	195.0	COG0296@1|root,COG1404@1|root,COG0296@2|Bacteria,COG1404@2|Bacteria,4NJ7Z@976|Bacteroidetes,1IZWQ@117747|Sphingobacteriia	976|Bacteroidetes	G	Glycogen recognition site of AMP-activated protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	AMPK1_CBM
k59_837838_1	644283.Micau_4827	8.16e-82	262.0	COG1960@1|root,COG1960@2|Bacteria,2GKK9@201174|Actinobacteria,4DB5R@85008|Micromonosporales	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, middle domain	fadE10	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,DUF1974
k59_226440_1	404589.Anae109_3703	1.45e-21	98.6	COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,42NJ0@68525|delta/epsilon subdivisions,2WJ7A@28221|Deltaproteobacteria,2YTYT@29|Myxococcales	28221|Deltaproteobacteria	M	Peptidase family M50	rseP	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
k59_1727413_1	926569.ANT_11800	9.87e-07	57.4	COG2203@1|root,COG3850@1|root,COG2203@2|Bacteria,COG3850@2|Bacteria	2|Bacteria	T	phosphorelay sensor kinase activity	-	-	2.7.13.3	ko:K07638,ko:K07673,ko:K21009	ko02020,ko02025,ko02026,map02020,map02025,map02026	M00445,M00471,M00742,M00743	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	AAA_16,GAF,GAF_2,GGDEF,HAMP,HATPase_c,HD,HisKA,PAS_3,PAS_9,PilJ,Pkinase,Response_reg,SpoIIE
k59_1616152_1	383407.XOC_1406	3.26e-35	139.0	COG0308@1|root,COG0308@2|Bacteria,1MUV3@1224|Proteobacteria,1RS0E@1236|Gammaproteobacteria,1X34X@135614|Xanthomonadales	135614|Xanthomonadales	E	aminopeptidase n	-	-	-	-	-	-	-	-	-	-	-	-	Big_4,Peptidase_M1
k59_782364_1	671143.DAMO_2062	1.14e-185	535.0	COG0498@1|root,COG0498@2|Bacteria,2NP42@2323|unclassified Bacteria	2|Bacteria	E	Threonine synthase	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	LeuA_dimer,PALP
k59_282141_1	1313172.YM304_39000	1.98e-106	332.0	COG0542@1|root,COG0542@2|Bacteria,2GJ73@201174|Actinobacteria,4CMTX@84992|Acidimicrobiia	84992|Acidimicrobiia	O	C-terminal, D2-small domain, of ClpB protein	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_115210_2	1120792.JAFV01000001_gene2323	2.3e-47	165.0	COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,2TQWH@28211|Alphaproteobacteria,36XPH@31993|Methylocystaceae	28211|Alphaproteobacteria	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_893721_1	1121957.ATVL01000010_gene355	1.01e-29	110.0	COG3631@1|root,COG3631@2|Bacteria,4NQGX@976|Bacteroidetes,47R4P@768503|Cytophagia	976|Bacteroidetes	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
k59_893721_2	1121091.AUMP01000023_gene3824	3.68e-18	82.0	COG1280@1|root,COG1280@2|Bacteria,1UB1Q@1239|Firmicutes,4HAM9@91061|Bacilli	91061|Bacilli	E	LysE type translocator	-	-	-	-	-	-	-	-	-	-	-	-	LysE
k59_1338354_1	1121033.AUCF01000005_gene5390	1.74e-69	223.0	COG0624@1|root,COG0624@2|Bacteria,1MW6G@1224|Proteobacteria,2TT0J@28211|Alphaproteobacteria,2JQ29@204441|Rhodospirillales	204441|Rhodospirillales	E	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls	dapE	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
k59_615532_1	526222.Desal_3743	8.1e-33	122.0	COG2203@1|root,COG2203@2|Bacteria,1RHTM@1224|Proteobacteria,42SY3@68525|delta/epsilon subdivisions,2WP4G@28221|Deltaproteobacteria,2MADU@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM GAF domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2
k59_1171507_1	526225.Gobs_2572	1.28e-16	84.3	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,4ETGG@85013|Frankiales	201174|Actinobacteria	K	transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,BTAD,Guanylate_cyc,NB-ARC,Trans_reg_C
k59_671308_1	1267535.KB906767_gene5178	1.41e-37	135.0	2C2MA@1|root,2Z87X@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_671308_2	314230.DSM3645_13318	4.65e-32	118.0	COG1845@1|root,COG1845@2|Bacteria	2|Bacteria	C	cytochrome c oxidase, subunit III	-	-	1.9.3.1	ko:K02276,ko:K02299	ko00190,ko01100,map00190,map01100	M00155,M00417	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.5,3.D.4.6	-	-	COX3
k59_282168_1	1123267.JONN01000001_gene900	9.67e-58	199.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,2TU21@28211|Alphaproteobacteria,2K2JW@204457|Sphingomonadales	204457|Sphingomonadales	C	COG1014 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, gamma subunit	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
k59_1671939_1	1123024.AUII01000006_gene4636	2.36e-59	207.0	COG3696@1|root,COG3696@2|Bacteria,2I53X@201174|Actinobacteria,4EE9U@85010|Pseudonocardiales	201174|Actinobacteria	P	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_726964_1	1122929.KB908236_gene386	5.15e-25	109.0	COG0318@1|root,COG0318@2|Bacteria,1MV6U@1224|Proteobacteria,2TT3F@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	AMP-binding enzyme	MA20_13015	-	-	-	-	-	-	-	-	-	-	-	AMP-binding
k59_782393_1	996637.SGM_0205	3.42e-50	173.0	COG0624@1|root,COG0624@2|Bacteria,2GMH2@201174|Actinobacteria	201174|Actinobacteria	E	peptidase	-	-	3.4.17.11	ko:K01295	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
k59_448977_1	1122132.AQYH01000006_gene3426	6.56e-12	72.8	COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2TVYB@28211|Alphaproteobacteria,4B9QH@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Histidine kinase	pdhS	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_8,PAS_9
k59_893751_1	1121334.KB911067_gene72	2.26e-52	176.0	COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia,3WGTC@541000|Ruminococcaceae	186801|Clostridia	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_1227582_1	316067.Geob_3098	2.82e-42	156.0	COG1480@1|root,COG1480@2|Bacteria,1NCY5@1224|Proteobacteria,42MI9@68525|delta/epsilon subdivisions,2WJI1@28221|Deltaproteobacteria,43UC4@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Metal-dependent phosphohydrolase	-	-	-	ko:K07037	-	-	-	-	ko00000	-	-	-	7TM-7TMR_HD,7TMR-HDED,HD
k59_1560683_1	945713.IALB_1070	5.78e-64	212.0	COG1012@1|root,COG1012@2|Bacteria	2|Bacteria	C	belongs to the aldehyde dehydrogenase family	pruA	-	1.2.1.88	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	-	R00245,R00707,R00708,R04444,R04445,R05051	RC00080,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000	-	-	-	Aldedh
k59_1449751_1	357808.RoseRS_2842	6.26e-32	132.0	COG2199@1|root,COG2203@1|root,COG2199@2|Bacteria,COG2203@2|Bacteria,2G8CK@200795|Chloroflexi,3776C@32061|Chloroflexia	32061|Chloroflexia	T	PFAM GGDEF domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF
k59_504576_2	1121861.KB899940_gene3753	4.47e-40	134.0	COG0184@1|root,COG0184@2|Bacteria,1MZ2W@1224|Proteobacteria,2UBRZ@28211|Alphaproteobacteria,2JT89@204441|Rhodospirillales	204441|Rhodospirillales	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
k59_504576_3	1382303.JPOM01000001_gene2426	5.18e-47	167.0	COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,2TRH3@28211|Alphaproteobacteria,2KF6S@204458|Caulobacterales	204458|Caulobacterales	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
k59_226517_1	292459.STH773	9.88e-19	90.5	COG1129@1|root,COG1879@1|root,COG1129@2|Bacteria,COG1879@2|Bacteria,1TP6I@1239|Firmicutes,247II@186801|Clostridia	186801|Clostridia	G	import. Responsible for energy coupling to the transport system	rbsA	-	3.6.3.17	ko:K10441,ko:K10542	ko02010,map02010	M00212,M00214	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.3	-	-	ABC_tran
k59_282211_2	713586.KB900536_gene1521	7e-26	99.4	COG2963@1|root,COG2963@2|Bacteria,1N3E0@1224|Proteobacteria,1S9T7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	COG2963 Transposase and inactivated derivatives	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_282211_3	1223544.GSI01S_10_02550	5.17e-14	73.6	COG2801@1|root,COG2801@2|Bacteria,2GKDY@201174|Actinobacteria,4GFMR@85026|Gordoniaceae	201174|Actinobacteria	L	HTH-like domain	tnp7109-46	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve
k59_1282827_1	266834.SM_b21056	2.93e-40	152.0	COG3291@1|root,COG3828@1|root,COG3291@2|Bacteria,COG3828@2|Bacteria	2|Bacteria	N	Trehalose utilisation	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,UnbV_ASPIC,VCBS
k59_4321_1	696747.NIES39_Q02600	6.83e-97	295.0	COG3288@1|root,COG3288@2|Bacteria,1G1D1@1117|Cyanobacteria,1H7A5@1150|Oscillatoriales	1117|Cyanobacteria	C	NAD NADP transhydrogenase alpha subunit	pntA	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N,PNTB_4TM
k59_1116259_1	582515.KR51_00016970	3.09e-26	110.0	COG1680@1|root,COG1680@2|Bacteria,1G5Z2@1117|Cyanobacteria	1117|Cyanobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_282264_1	1318628.MARLIPOL_06184	3.51e-41	147.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,1RMAQ@1236|Gammaproteobacteria,465EU@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	COG3547 Transposase and inactivated derivatives	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_782490_1	1245469.S58_55000	1.28e-63	217.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,2TR3C@28211|Alphaproteobacteria,3JSHW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	pyruvate phosphate dikinase	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_115328_1	981369.JQMJ01000004_gene2472	3.99e-36	137.0	COG0635@1|root,COG0635@2|Bacteria,2GJXX@201174|Actinobacteria,2NEEP@228398|Streptacidiphilus	201174|Actinobacteria	H	Elongator protein 3, MiaB family, Radical SAM	hemN	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	-	-	-	-	-	-	-	-	-	iNJ661.Rv2388c	HemN_C,Radical_SAM
k59_782499_1	1217714.F975_01329	4.34e-33	129.0	COG2114@1|root,COG2114@2|Bacteria,1MV1V@1224|Proteobacteria,1RYBQ@1236|Gammaproteobacteria,3NJJW@468|Moraxellaceae	1236|Gammaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	cyaB	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,MASE2
k59_115329_1	1123237.Salmuc_01626	4.96e-87	271.0	COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,2U3FU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase_2,Cu-oxidase_3
k59_837975_1	1120968.AUBX01000009_gene333	9.57e-60	204.0	COG2234@1|root,COG2234@2|Bacteria,4NI5W@976|Bacteroidetes,47MK3@768503|Cytophagia	976|Bacteroidetes	S	glutamate carboxypeptidase	-	-	3.4.17.21	ko:K01301	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PA,Peptidase_M28,TFR_dimer
k59_1616285_1	1125863.JAFN01000001_gene2764	1e-59	202.0	COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,1MU9M@1224|Proteobacteria,42NEZ@68525|delta/epsilon subdivisions,2WJ5R@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	AAA domain	-	-	-	ko:K07028	-	-	-	-	ko00000	-	-	-	AAA_33,APH
k59_1171626_1	234267.Acid_1765	4.34e-13	71.6	COG0577@1|root,COG0577@2|Bacteria	234267.Acid_1765|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1171626_2	1121104.AQXH01000001_gene1386	1.26e-05	47.8	COG2091@1|root,COG2091@2|Bacteria,4NGXG@976|Bacteroidetes	976|Bacteroidetes	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
k59_4373_1	344747.PM8797T_28489	2.33e-157	454.0	COG0367@1|root,COG0367@2|Bacteria,2IYMU@203682|Planctomycetes	203682|Planctomycetes	E	Asparagine synthase	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase
k59_559934_1	395493.BegalDRAFT_2300	1.45e-81	271.0	COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,45ZWV@72273|Thiotrichales	72273|Thiotrichales	E	Glutamate synthase	gltB	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_1449841_1	1125863.JAFN01000001_gene3399	2.94e-47	172.0	COG0749@1|root,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,42NAV@68525|delta/epsilon subdivisions,2WJ3W@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_4381_1	1122609.AUGT01000017_gene872	8.31e-21	83.2	COG0267@1|root,COG0267@2|Bacteria,2GQFG@201174|Actinobacteria	201174|Actinobacteria	J	Belongs to the bacterial ribosomal protein bL33 family	rpmG	-	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
k59_4381_2	935948.KE386495_gene1527	1.24e-52	176.0	COG0050@1|root,COG0050@2|Bacteria,1TPKC@1239|Firmicutes,2485I@186801|Clostridia,42EPJ@68295|Thermoanaerobacterales	186801|Clostridia	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
k59_115346_1	1000565.METUNv1_01810	7.36e-41	141.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,2VKVM@28216|Betaproteobacteria,2KUFD@206389|Rhodocyclales	206389|Rhodocyclales	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_11
k59_839660_1	926569.ANT_26930	3.66e-16	82.4	COG0370@1|root,COG0370@2|Bacteria	2|Bacteria	P	ferrous iron transmembrane transporter activity	feoB	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
k59_1229609_1	716544.wcw_1641	3.18e-19	87.4	COG1619@1|root,COG1619@2|Bacteria,2JG3B@204428|Chlamydiae	204428|Chlamydiae	V	LD-carboxypeptidase	ykfA	-	3.4.17.13	ko:K01297	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_S66
k59_1229609_2	1401078.HMPREF2140_05715	1.14e-18	89.0	COG1680@1|root,COG2755@1|root,COG1680@2|Bacteria,COG2755@2|Bacteria,4NIWV@976|Bacteroidetes,2G0A2@200643|Bacteroidia	976|Bacteroidetes	EV	beta-lactamase	estA	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,Lipase_GDSL,Lipase_GDSL_2
k59_1395748_2	443152.MDG893_07685	2.04e-51	171.0	COG0559@1|root,COG0559@2|Bacteria,1MVND@1224|Proteobacteria,1SZ2D@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
k59_1284584_1	1128427.KB904821_gene2004	1.16e-20	97.1	COG0642@1|root,COG0745@1|root,COG2202@1|root,COG5002@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1G09B@1117|Cyanobacteria,1H7M4@1150|Oscillatoriales	1117|Cyanobacteria	T	Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor domain	-	-	2.7.13.3	ko:K11527	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	CBS,GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
k59_61555_1	340099.Teth39_0902	8.99e-71	231.0	COG1884@1|root,COG1884@2|Bacteria,1TQAD@1239|Firmicutes,24BDK@186801|Clostridia,42FIA@68295|Thermoanaerobacterales	186801|Clostridia	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01847,ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
k59_450868_1	1267534.KB906757_gene956	3.2e-64	225.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Pkinase,Trans_reg_C,WD40
k59_395073_1	1123242.JH636435_gene1377	8.46e-27	109.0	COG1611@1|root,COG1611@2|Bacteria,2IXIR@203682|Planctomycetes	203682|Planctomycetes	S	Rossmann fold nucleotide-binding protein	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
k59_1118105_2	399550.Smar_0504	1.89e-25	101.0	COG1335@1|root,arCOG01943@2157|Archaea,2XQK1@28889|Crenarchaeota	28889|Crenarchaeota	Q	PFAM Isochorismatase	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
k59_784224_1	526225.Gobs_2273	2.82e-09	60.1	COG1247@1|root,COG1247@2|Bacteria,2IMVR@201174|Actinobacteria,4EWXB@85013|Frankiales	201174|Actinobacteria	M	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_895682_1	926569.ANT_28800	4.79e-58	193.0	COG0183@1|root,COG0183@2|Bacteria,2G63J@200795|Chloroflexi	200795|Chloroflexi	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_1340242_1	497965.Cyan7822_5348	1.09e-60	206.0	COG1134@1|root,COG1134@2|Bacteria,1G28R@1117|Cyanobacteria,3KHG3@43988|Cyanothece	1117|Cyanobacteria	GM	PFAM ABC transporter related	-	-	-	ko:K09691	ko02010,map02010	M00250	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.103	-	-	ABC_tran,Wzt_C
k59_1284632_1	102125.Xen7305DRAFT_00040470	2.88e-05	45.4	COG0003@1|root,COG0003@2|Bacteria,1G1UB@1117|Cyanobacteria,3VI0B@52604|Pleurocapsales	1117|Cyanobacteria	P	Arsenite-activated ATPase ArsA	-	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase
k59_1284632_2	40571.JOEA01000001_gene5274	1.32e-23	97.4	COG2867@1|root,COG2867@2|Bacteria,2IFH4@201174|Actinobacteria,4E3HW@85010|Pseudonocardiales	201174|Actinobacteria	I	PFAM Polyketide cyclase dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc,Polyketide_cyc2
k59_1395813_1	717231.Flexsi_1951	1.09e-07	58.9	COG4775@1|root,COG4775@2|Bacteria,2GFAK@200930|Deferribacteres	200930|Deferribacteres	M	surface antigen (D15)	-	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
k59_117018_1	1047013.AQSP01000140_gene2527	4.47e-21	97.8	COG1044@1|root,COG1044@2|Bacteria,2NQT1@2323|unclassified Bacteria	2|Bacteria	M	SpoIVB peptidase S55	-	-	2.7.7.24	ko:K00973,ko:K02414,ko:K21449	ko00521,ko00523,ko00525,ko01130,ko02040,map00521,map00523,map00525,map01130,map02040	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000,ko02000,ko02035	1.B.40.2	-	-	AMP-binding,APH,DUF4114,DUF4842,Hexapep,PP-binding,Peptidase_S55
k59_1562602_1	877455.Metbo_1377	1.83e-72	231.0	COG0183@1|root,arCOG01278@2157|Archaea,2XT38@28890|Euryarchaeota,23NRQ@183925|Methanobacteria	183925|Methanobacteria	I	Thiolase, N-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_1395816_1	349124.Hhal_0419	1.74e-132	389.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,1RRUS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	hmm pf01609	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
k59_839730_1	1122135.KB893135_gene1078	4.31e-51	171.0	COG4927@1|root,COG4927@2|Bacteria,1MY0W@1224|Proteobacteria,2TTM1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	choloylglycine hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	AAT
k59_839730_2	1122135.KB893135_gene1079	1.73e-36	135.0	COG0439@1|root,COG0439@2|Bacteria,1R5XW@1224|Proteobacteria,2TU28@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Biotin carboxylase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_6176_1	1121875.KB907552_gene313	1.47e-27	115.0	COG1082@1|root,COG1082@2|Bacteria,4NEWC@976|Bacteroidetes,1HY05@117743|Flavobacteriia	976|Bacteroidetes	G	Alpha-glucosidase	-	-	3.2.1.20,3.2.1.3	ko:K01187,ko:K21574	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R01790,R01791,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31,GH97	-	GH97_C,GH97_N,Glyco_hydro_97
k59_395135_2	1144310.PMI07_001937	2.69e-43	154.0	COG0715@1|root,COG0715@2|Bacteria,1QYYM@1224|Proteobacteria,2TY1N@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	NMT1/THI5 like	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
k59_228479_1	644966.Tmar_1145	1.17e-30	122.0	COG4974@1|root,COG4974@2|Bacteria,1TQRG@1239|Firmicutes,247QQ@186801|Clostridia,3WD2S@538999|Clostridiales incertae sedis	186801|Clostridia	L	Phage integrase, N-terminal SAM-like domain	xerD	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_1229715_1	450851.PHZ_c1673	8.27e-66	211.0	2CCCK@1|root,2Z7UH@2|Bacteria,1R3SV@1224|Proteobacteria,2UH90@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1395842_1	254397.B6ETC4_9CAUD	0.00032	46.2	4QNHR@10744|Podoviridae	10744|Podoviridae	S	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_784298_1	1045855.DSC_14445	0.000795	48.5	COG1640@1|root,COG1640@2|Bacteria,1QTVJ@1224|Proteobacteria,1RMJW@1236|Gammaproteobacteria,1X3KU@135614|Xanthomonadales	135614|Xanthomonadales	G	4-alpha-glucanotransferase	malQ	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
k59_1023017_2	1131730.BAVI_04984	1.62e-42	152.0	COG1172@1|root,COG1172@2|Bacteria,1TP72@1239|Firmicutes,4H9Y3@91061|Bacilli,1ZBAZ@1386|Bacillus	91061|Bacilli	G	Belongs to the binding-protein-dependent transport system permease family	rbsC	-	-	ko:K17214	ko02010,map02010	M00593	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
k59_912244_1	575540.Isop_0659	4.41e-26	113.0	COG1287@1|root,COG1287@2|Bacteria,2J0B8@203682|Planctomycetes	203682|Planctomycetes	S	oligosaccharyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_299686_1	445972.ANACOL_02827	5.01e-09	62.8	COG1529@1|root,COG1529@2|Bacteria,1TP7U@1239|Firmicutes,248BV@186801|Clostridia,3WHIV@541000|Ruminococcaceae	186801|Clostridia	C	Psort location CytoplasmicMembrane, score	mop	-	1.2.99.7	ko:K07469	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2
k59_1300371_1	1173026.Glo7428_3328	3.42e-10	65.1	COG2319@1|root,COG2319@2|Bacteria,1G208@1117|Cyanobacteria	1117|Cyanobacteria	S	Wd-40 repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_77087_1	1380394.JADL01000001_gene2042	1.14e-76	247.0	COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2TQP0@28211|Alphaproteobacteria,2JPA1@204441|Rhodospirillales	204441|Rhodospirillales	P	COG1123 ATPase components of various ABC-type transport systems, contain duplicated ATPase	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_1632964_1	991905.SL003B_4273	1.53e-117	348.0	COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,2TQSN@28211|Alphaproteobacteria,4BPFY@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Serine-pyruvate aminotransferase archaeal aspartate aminotransferase	MA20_39235	-	2.6.1.44,2.6.1.45,2.6.1.51	ko:K00830	ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	M00346,M00532	R00369,R00372,R00585,R00588	RC00006,RC00008,RC00018	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
k59_1578286_1	1045858.Bint_2105	1.4e-11	69.3	2E8ZQ@1|root,33397@2|Bacteria,2J942@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1134197_1	479434.Sthe_2526	1.17e-48	176.0	COG2197@1|root,COG3903@1|root,COG2197@2|Bacteria,COG3903@2|Bacteria,2G7W3@200795|Chloroflexi,27ZD0@189775|Thermomicrobia	200795|Chloroflexi	K	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	GerE,TPR_12
k59_21852_1	309807.SRU_1297	1.14e-15	79.3	COG4772@1|root,COG4772@2|Bacteria,4NE9I@976|Bacteroidetes,1FIQA@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	P	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
k59_1189181_1	666684.AfiDRAFT_2539	3.71e-137	411.0	COG2132@1|root,COG3474@1|root,COG4454@1|root,COG2132@2|Bacteria,COG3474@2|Bacteria,COG4454@2|Bacteria,1MV74@1224|Proteobacteria,2U1BK@28211|Alphaproteobacteria,3JV1C@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Copper binding proteins, plastocyanin/azurin family	-	-	1.7.2.1	ko:K00368	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Copper-bind,Cu-oxidase_2,Cu-oxidase_3,Cytochrom_C
k59_1023053_1	671143.DAMO_1343	1.78e-55	183.0	COG0101@1|root,COG0101@2|Bacteria,2NPEC@2323|unclassified Bacteria	2|Bacteria	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
k59_1467375_1	316274.Haur_0285	8.04e-32	120.0	COG2152@1|root,COG2152@2|Bacteria,2G6ZE@200795|Chloroflexi	200795|Chloroflexi	G	PFAM glycosidase PH1107-related	-	-	2.4.1.319,2.4.1.320,2.4.1.339,2.4.1.340	ko:K18785,ko:K20885	-	-	R10811,R10829,R11397,R11398	RC00049,RC02748	ko00000,ko01000	-	GH130	-	Glyco_hydro_130
k59_1411643_1	1123355.JHYO01000025_gene2152	6.07e-116	347.0	COG4108@1|root,COG4108@2|Bacteria,1MU7X@1224|Proteobacteria,2TRP5@28211|Alphaproteobacteria,36XHH@31993|Methylocystaceae	28211|Alphaproteobacteria	J	Class II release factor RF3, C-terminal domain	prfC	-	-	ko:K02837	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,RF3_C
k59_243987_1	1502850.FG91_02005	2.19e-12	70.5	COG1450@1|root,COG4796@1|root,COG1450@2|Bacteria,COG4796@2|Bacteria,1MUUA@1224|Proteobacteria,2TT8A@28211|Alphaproteobacteria,2K22S@204457|Sphingomonadales	204457|Sphingomonadales	NU	Type II secretion system protein D	gspD	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Secretin,Secretin_N
k59_1189195_1	1121403.AUCV01000029_gene2663	0.000224	47.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,42M1X@68525|delta/epsilon subdivisions,2WJA2@28221|Deltaproteobacteria,2MHZK@213118|Desulfobacterales	28221|Deltaproteobacteria	EH	TIGRFAM acetolactate synthase, large subunit, biosynthetic type	-	-	-	-	-	-	-	-	-	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_632341_1	1120942.AUBM01000006_gene1087	7.82e-64	221.0	COG0247@1|root,COG0247@2|Bacteria,2GJ7M@201174|Actinobacteria,4D30W@85005|Actinomycetales	201174|Actinobacteria	C	Cysteine-rich domain protein	fadF	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
k59_1077863_1	880073.Calab_2065	3.49e-21	98.6	COG1629@1|root,COG4771@2|Bacteria,2NP6Z@2323|unclassified Bacteria	2|Bacteria	P	COGs COG1629 Outer membrane receptor protein mostly Fe transport	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec
k59_577189_1	886293.Sinac_7060	2.84e-12	70.1	COG0304@1|root,COG0304@2|Bacteria,2IWRA@203682|Planctomycetes	2|Bacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_577189_2	1254432.SCE1572_31295	7.43e-22	89.0	COG4319@1|root,COG4319@2|Bacteria,1NKFM@1224|Proteobacteria	1224|Proteobacteria	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440,SnoaL_2,SnoaL_3
k59_1411654_2	1307761.L21SP2_1378	4.94e-11	62.8	COG1664@1|root,COG1664@2|Bacteria,2J85N@203691|Spirochaetes	203691|Spirochaetes	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
k59_1744711_1	1499967.BAYZ01000036_gene2438	3.03e-59	192.0	COG0330@1|root,COG0330@2|Bacteria,2NP2X@2323|unclassified Bacteria	2|Bacteria	O	HflC and HflK could regulate a protease	hflC	-	-	ko:K04087	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
k59_1744711_2	439235.Dalk_0720	2.24e-12	67.4	COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,42NUT@68525|delta/epsilon subdivisions,2WKQX@28221|Deltaproteobacteria,2MI5I@213118|Desulfobacterales	28221|Deltaproteobacteria	O	HflC and HflK could encode or regulate a protease	hflK	-	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
k59_1300431_2	861299.J421_3045	8.61e-20	91.7	COG0515@1|root,COG0515@2|Bacteria,1ZUBQ@142182|Gemmatimonadetes	861299.J421_3045|-	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	-
k59_467331_1	631454.N177_1694	3.41e-10	60.5	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TVI3@28211|Alphaproteobacteria,1JN67@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	-	-	-	-	-	-	-	-	-	TctA
k59_1467411_2	1123373.ATXI01000021_gene926	2.73e-58	197.0	COG0038@1|root,COG0038@2|Bacteria,2GHV5@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	P	Voltage gated chloride channel	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,Voltage_CLC
k59_1300444_1	65393.PCC7424_4937	3.27e-40	154.0	COG0457@1|root,COG0457@2|Bacteria,1G8AT@1117|Cyanobacteria	1117|Cyanobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF4071
k59_1411672_1	1175306.GWL_17810	1.23e-88	280.0	COG0399@1|root,COG0399@2|Bacteria,1MUMJ@1224|Proteobacteria,2VQRJ@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Putative transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
k59_800296_1	1267534.KB906761_gene1203	3.8e-68	223.0	COG2072@1|root,COG2072@2|Bacteria	2|Bacteria	P	N,N-dimethylaniline monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	FAD_oxidored,FMO-like,K_oxygenase
k59_132421_1	105559.Nwat_0159	1.95e-06	55.1	COG0672@1|root,COG2010@1|root,COG0672@2|Bacteria,COG2010@2|Bacteria,1MXHM@1224|Proteobacteria,1RMWB@1236|Gammaproteobacteria,1WXW1@135613|Chromatiales	135613|Chromatiales	P	Iron permease FTR1	-	-	-	ko:K07243	-	-	-	-	ko00000,ko02000	2.A.108.1,2.A.108.2	-	-	Cytochrome_CBB3,FTR1
k59_1300453_1	1045009.AFXQ01000001_gene2163	3.95e-45	167.0	COG0067@1|root,COG0069@1|root,COG0493@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0493@2|Bacteria,2GN09@201174|Actinobacteria,1W7MB@1268|Micrococcaceae	201174|Actinobacteria	E	Glutamate synthase	gltB	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_1190991_1	1480694.DC28_10220	1.69e-45	163.0	COG0512@1|root,COG0547@1|root,COG0512@2|Bacteria,COG0547@2|Bacteria,2J59H@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase,Glycos_trans_3N,Glycos_transf_3
k59_1524445_1	1340493.JNIF01000003_gene1701	8.13e-21	96.3	COG0154@1|root,COG0154@2|Bacteria,3Y3E5@57723|Acidobacteria	57723|Acidobacteria	J	PFAM Amidase	-	-	-	-	-	-	-	-	-	-	-	-	Amidase
k59_691061_1	945713.IALB_0020	5.72e-55	175.0	COG4747@1|root,COG4747@2|Bacteria	2|Bacteria	-	-	hom	-	1.1.1.3,1.1.1.399,1.1.1.95,1.3.1.12,4.3.1.19	ko:K00003,ko:K00058,ko:K01754,ko:K04517,ko:K04767	ko00260,ko00270,ko00290,ko00300,ko00400,ko00401,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00290,map00300,map00400,map00401,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00017,M00018,M00020,M00025,M00570	R00220,R00996,R01513,R01728,R01773,R01775	RC00031,RC00087,RC00125,RC00418,RC02600	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT,CBS,Homoserine_dh,Lactamase_B,NAD_binding_3
k59_1580092_1	264732.Moth_1961	4.44e-48	160.0	COG2080@1|root,COG2080@2|Bacteria,1V6HE@1239|Firmicutes,24J9B@186801|Clostridia,42I67@68295|Thermoanaerobacterales	186801|Clostridia	C	[2Fe-2S] binding domain	-	-	1.2.5.3	ko:K03518,ko:K13483	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103,R11168	RC00143,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2,Fer2_2
k59_523842_1	1379270.AUXF01000001_gene2466	7.51e-65	211.0	COG0183@1|root,COG0183@2|Bacteria,1ZSW1@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Thiolase, C-terminal domain	-	-	2.3.1.16	ko:K00632	ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212	M00087,M00113	R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000	-	-	-	Thiolase_C,Thiolase_N
k59_634009_1	1268622.AVS7_02675	1.86e-06	56.6	COG3637@1|root,COG5272@1|root,COG3637@2|Bacteria,COG5272@2|Bacteria,1QVUE@1224|Proteobacteria	1224|Proteobacteria	M	Protein involved in outer membrane biogenesis	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG,OMP_b-brl,fn3
k59_914296_2	1121875.KB907555_gene370	1.33e-103	309.0	COG1830@1|root,COG1830@2|Bacteria,4NEUM@976|Bacteroidetes,1HZ0Q@117743|Flavobacteriia	976|Bacteroidetes	G	PFAM DeoC LacD family aldolase	fbaB	-	4.1.2.13	ko:K11645	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
k59_1025142_1	671143.DAMO_1616	2.95e-56	194.0	COG1034@1|root,COG1034@2|Bacteria	2|Bacteria	C	ATP synthesis coupled electron transport	nuoG	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdop_Fe4S4,Molybdopterin,NADH-G_4Fe-4S_3
k59_78802_1	105559.Nwat_0972	1.98e-88	280.0	COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria,1WW27@135613|Chromatiales	135613|Chromatiales	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
k59_969121_1	1209984.BN978_06598	7.51e-68	216.0	COG0010@1|root,COG0010@2|Bacteria,2GJA6@201174|Actinobacteria,234A3@1762|Mycobacteriaceae	201174|Actinobacteria	E	Belongs to the arginase family	speB	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
k59_1634576_1	550540.Fbal_0267	2.79e-12	72.0	COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,1MVI9@1224|Proteobacteria,1RNB0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	D	protein involved in exopolysaccharide biosynthesis	-	-	-	ko:K16554	ko05111,map05111	-	-	-	ko00000,ko00001,ko02000	8.A.3.1	-	-	AAA_31,CBP_BcsQ,CbiA,GNVR,Wzz
k59_1025149_1	1123008.KB905697_gene3316	6.72e-67	225.0	COG1882@1|root,COG1882@2|Bacteria,4NDWW@976|Bacteroidetes,2FMC2@200643|Bacteroidia,22WNW@171551|Porphyromonadaceae	976|Bacteroidetes	C	Pyruvate formate lyase-like	-	-	2.3.1.54,4.1.1.83	ko:K00656,ko:K18427	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
k59_78806_1	1178825.ALIH01000018_gene1151	3.97e-06	53.5	COG0223@1|root,COG0223@2|Bacteria,4NNM5@976|Bacteroidetes,1I273@117743|Flavobacteriia	976|Bacteroidetes	J	Formyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Formyl_trans_N
k59_1691676_1	926559.JoomaDRAFT_2011	2.13e-74	231.0	COG0142@1|root,COG0142@2|Bacteria,4NET2@976|Bacteroidetes,1HWY7@117743|Flavobacteriia	976|Bacteroidetes	H	Belongs to the FPP GGPP synthase family	ispB	-	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110	-	R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
k59_1691680_1	1379698.RBG1_1C00001G1160	3.63e-05	45.4	COG1185@1|root,COG1185@2|Bacteria,2NNX7@2323|unclassified Bacteria	2|Bacteria	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016020,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030312,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
k59_1691680_2	1229205.BUPH_05164	2.07e-29	107.0	COG0184@1|root,COG0184@2|Bacteria,1MZ2W@1224|Proteobacteria,2VU1D@28216|Betaproteobacteria,1K8J9@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
k59_801926_1	1380380.JIAX01000007_gene29	2.42e-40	145.0	COG0628@1|root,COG0628@2|Bacteria,1MXXU@1224|Proteobacteria,2TVPN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	permease	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
k59_469345_1	1123354.AUDR01000017_gene75	7.43e-53	177.0	COG0159@1|root,COG0159@2|Bacteria,1MXJV@1224|Proteobacteria,2VI78@28216|Betaproteobacteria,1KSRE@119069|Hydrogenophilales	119069|Hydrogenophilales	E	Tryptophan synthase alpha chain	-	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
k59_469345_2	1473546.CH76_01090	8.68e-15	73.9	COG0133@1|root,COG0133@2|Bacteria,1TPI3@1239|Firmicutes,4H9WC@91061|Bacilli,3IWYM@400634|Lysinibacillus	91061|Bacilli	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.20,5.3.1.24	ko:K01696,ko:K01817	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722,R03509	RC00209,RC00210,RC00700,RC00701,RC00945,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU22640	PALP
k59_969145_1	861299.J421_5945	3.1e-30	120.0	COG1233@1|root,COG1233@2|Bacteria	2|Bacteria	Q	all-trans-retinol 13,14-reductase activity	-	-	1.5.99.6	ko:K00316	ko00330,ko00410,ko01100,map00330,map00410,map01100	-	R01914,R01915	RC00053,RC00225	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase,NAD_binding_8
k59_356502_1	472759.Nhal_2611	2.38e-08	54.7	COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,1RN9D@1236|Gammaproteobacteria,1X2EW@135613|Chromatiales	135613|Chromatiales	C	Cytochrome c oxidase subunit III	-	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
k59_356502_2	1231391.AMZF01000013_gene2540	0.000237	44.7	2DR0H@1|root,339NS@2|Bacteria,1NI23@1224|Proteobacteria	1224|Proteobacteria	S	TIGRFAM Caa(3)-type oxidase, subunit IV	-	-	1.9.3.1	ko:K02277	ko00190,ko01100,map00190,map01100	M00155	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.4	-	-	COX4_pro
k59_1413302_1	1206730.BAGA01000073_gene1903	4.54e-29	119.0	COG2079@1|root,COG2079@2|Bacteria,2GKUR@201174|Actinobacteria,4FX40@85025|Nocardiaceae	201174|Actinobacteria	S	MmgE/PrpD family	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
k59_1524480_1	439235.Dalk_3539	1.65e-66	209.0	COG0223@1|root,COG0223@2|Bacteria,1Q7FH@1224|Proteobacteria,430U1@68525|delta/epsilon subdivisions,2WVN7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	PFAM Formyl transferase	-	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_N
k59_914344_1	234267.Acid_2435	5.85e-09	59.3	COG0160@1|root,COG0160@2|Bacteria,3Y3P2@57723|Acidobacteria	57723|Acidobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.19,2.6.1.22	ko:K00823,ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_914344_2	861299.J421_4381	8.59e-33	116.0	COG2154@1|root,COG2154@2|Bacteria,1ZU5C@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Pterin 4 alpha carbinolamine dehydratase	-	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
k59_523887_1	1296416.JACB01000026_gene3930	1.76e-14	79.7	COG0457@1|root,COG1680@1|root,COG0457@2|Bacteria,COG1680@2|Bacteria,4NGKK@976|Bacteroidetes,1HX0I@117743|Flavobacteriia,2YKMC@290174|Aquimarina	976|Bacteroidetes	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,DUF3471,TPR_2
k59_189902_1	292415.Tbd_2587	5.96e-66	214.0	COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,2VI4X@28216|Betaproteobacteria,1KRF7@119069|Hydrogenophilales	119069|Hydrogenophilales	H	DNA / pantothenate metabolism flavoprotein	-	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
k59_412669_1	357804.Ping_1814	3.33e-55	180.0	COG1226@1|root,COG1226@2|Bacteria,1QYC1@1224|Proteobacteria	1224|Proteobacteria	P	COG1226 Kef-type K transport systems	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans,Ion_trans_2
k59_412669_2	1121939.L861_17625	1.07e-12	65.5	COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,1RMF7@1236|Gammaproteobacteria,1XIZH@135619|Oceanospirillales	135619|Oceanospirillales	O	Belongs to the GST superfamily	-	-	-	ko:K11209	-	-	-	-	ko00000,ko01000	-	-	-	GST_C,GST_N
k59_1413329_1	991905.SL003B_0630	5.79e-32	114.0	COG2963@1|root,COG2963@2|Bacteria,1MZ3D@1224|Proteobacteria,2UBSS@28211|Alphaproteobacteria,4BSEM@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_1413329_2	1166948.JPZL01000004_gene179	1.91e-72	226.0	COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,1RR8F@1236|Gammaproteobacteria,1XRIQ@135619|Oceanospirillales	135619|Oceanospirillales	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve_3
k59_856227_1	1044.EH31_07695	1.57e-54	185.0	COG2189@1|root,COG2189@2|Bacteria,1MX9M@1224|Proteobacteria,2TSW9@28211|Alphaproteobacteria,2K0RE@204457|Sphingomonadales	204457|Sphingomonadales	L	Belongs to the N(4) N(6)-methyltransferase family	-	-	2.1.1.72	ko:K13581	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko02048	-	-	-	N6_N4_Mtase
k59_1302405_1	926550.CLDAP_08510	1.15e-23	102.0	COG1744@1|root,COG1744@2|Bacteria,2G6UB@200795|Chloroflexi	200795|Chloroflexi	M	PFAM basic membrane lipoprotein	-	-	-	ko:K07335	-	-	-	-	ko00000	-	-	-	Bmp
k59_969231_1	861299.J421_2596	8.39e-32	127.0	2EW4E@1|root,33PHK@2|Bacteria,1ZT53@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_23635_1	595460.RRSWK_03499	8.13e-27	113.0	COG2928@1|root,COG2928@2|Bacteria,2IZGR@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF502)	-	-	-	-	-	-	-	-	-	-	-	-	DUF502
k59_1025277_1	502025.Hoch_4147	1.65e-109	341.0	COG1529@1|root,COG2080@1|root,COG1529@2|Bacteria,COG2080@2|Bacteria,1MUEA@1224|Proteobacteria,42MER@68525|delta/epsilon subdivisions,2WIYV@28221|Deltaproteobacteria,2YW7P@29|Myxococcales	28221|Deltaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2
k59_1248375_1	926569.ANT_25290	2.4e-40	154.0	COG0653@1|root,COG0653@2|Bacteria,2G603@200795|Chloroflexi	200795|Chloroflexi	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_760036_2	926550.CLDAP_38130	3.41e-30	117.0	COG0472@1|root,COG0472@2|Bacteria,2G5TJ@200795|Chloroflexi	200795|Chloroflexi	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
k59_92897_1	384676.PSEEN2585	5.7e-13	68.9	COG0235@1|root,COG0235@2|Bacteria,1RB5Z@1224|Proteobacteria	1224|Proteobacteria	G	class II Aldolase	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II
k59_1427346_1	192952.MM_2455	1.37e-57	191.0	COG1131@1|root,arCOG00194@2157|Archaea,2XUK9@28890|Euryarchaeota,2N95K@224756|Methanomicrobia	224756|Methanomicrobia	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
k59_1262859_1	1382305.AZUC01000009_gene1813	3.33e-06	50.1	arCOG08054@1|root,2Z8AD@2|Bacteria,1TQ1J@1239|Firmicutes,4HDNN@91061|Bacilli,26E9Z@186818|Planococcaceae	91061|Bacilli	S	Carbohydrate-binding domain-containing protein Cthe_2159	-	-	-	-	-	-	-	-	-	-	-	-	Cthe_2159
k59_1262859_2	1380370.JIBA01000015_gene301	2.44e-16	73.9	29JYD@1|root,306VN@2|Bacteria,2GWXT@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1594854_1	1121896.JMLU01000003_gene2063	7.87e-38	134.0	COG1607@1|root,COG1607@2|Bacteria,4NMK1@976|Bacteroidetes,1I199@117743|Flavobacteriia,2NUKV@237|Flavobacterium	976|Bacteroidetes	I	thioesterase	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
k59_147799_1	648996.Theam_0684	5.4e-49	173.0	COG1966@1|root,COG1966@2|Bacteria,2G4H1@200783|Aquificae	200783|Aquificae	T	PFAM Carbon starvation protein CstA	cstA	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007154,GO:0008150,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031667,GO:0031668,GO:0031669,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051716,GO:0071496,GO:0071944	-	ko:K06200	-	-	-	-	ko00000	-	-	-	CstA,CstA_5TM
k59_36863_1	1237149.C900_03921	1.63e-41	155.0	COG2091@1|root,COG2091@2|Bacteria,4NFQ6@976|Bacteroidetes,47MUU@768503|Cytophagia	976|Bacteroidetes	H	Carbohydrate family 9 binding domain-like	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
k59_202949_1	1183438.GKIL_3014	1.35e-102	310.0	COG0031@1|root,COG0031@2|Bacteria,1G0T4@1117|Cyanobacteria	1117|Cyanobacteria	E	cysteine synthase	-	-	4.2.1.22	ko:K01697	ko00260,ko00270,ko01100,ko01130,ko01230,map00260,map00270,map01100,map01130,map01230	M00035,M00338	R00891,R01290,R04942	RC00056,RC00069,RC00256,RC00489,RC01246	ko00000,ko00001,ko00002,ko01000	-	-	-	CBS,PALP
k59_1483850_1	450851.PHZ_c2609	1.1e-66	213.0	COG0157@1|root,COG0157@2|Bacteria,1MW0C@1224|Proteobacteria,2TS7C@28211|Alphaproteobacteria,2KFMV@204458|Caulobacterales	204458|Caulobacterales	H	Belongs to the NadC ModD family	nadC	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
k59_1483850_2	1226322.HMPREF1545_00666	5.65e-15	76.3	COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,1TQCU@1239|Firmicutes,248CK@186801|Clostridia,2N6JS@216572|Oscillospiraceae	186801|Clostridia	K	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
k59_929922_1	1089544.KB912942_gene25	9.27e-06	50.1	COG2141@1|root,COG2141@2|Bacteria,2H0K9@201174|Actinobacteria,4E3AX@85010|Pseudonocardiales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_929922_2	1206739.BAGJ01000113_gene2488	3.22e-13	69.3	COG0243@1|root,COG0243@2|Bacteria,2GJCK@201174|Actinobacteria,4FVTT@85025|Nocardiaceae	201174|Actinobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	bisC	-	1.8.5.3,1.97.1.9	ko:K07306,ko:K07309,ko:K07310,ko:K08351	ko00450,ko00780,ko00920,ko01100,map00450,map00780,map00920,map01100	-	R07229,R09501,R10127	RC02420,RC02555,RC03056	ko00000,ko00001,ko01000,ko02000	5.A.3.3,5.A.3.4	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal
k59_815832_1	236097.ADG881_108	8.59e-19	84.7	COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,1RMFQ@1236|Gammaproteobacteria,1XI2X@135619|Oceanospirillales	135619|Oceanospirillales	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obgE	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GTP1_OBG,MMR_HSR1
k59_815832_2	1232683.ADIMK_0969	2.79e-33	116.0	COG0211@1|root,COG0211@2|Bacteria,1MZGH@1224|Proteobacteria,1S8R2@1236|Gammaproteobacteria,467SE@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	GO:0000027,GO:0001558,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040008,GO:0042254,GO:0042255,GO:0042256,GO:0042273,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048518,GO:0050789,GO:0050794,GO:0051128,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090069,GO:0090070,GO:1901564,GO:1901566,GO:1901576,GO:1902626,GO:1990904	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
k59_760089_1	1236689.MMALV_16610	2.41e-28	114.0	COG0247@1|root,arCOG00333@2157|Archaea,2Y85G@28890|Euryarchaeota	28890|Euryarchaeota	C	reductase	hdrD	GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009058,GO:0009061,GO:0009987,GO:0015947,GO:0015948,GO:0015975,GO:0015980,GO:0016491,GO:0016667,GO:0043446,GO:0043447,GO:0044237,GO:0044249,GO:0045333,GO:0051912,GO:0055114,GO:0071704,GO:1901576	1.8.98.1	ko:K08264	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	-	R04540	RC00011	ko00000,ko00001,ko01000	-	-	-	CCG,Fer4_17,Fer4_8
k59_258976_2	929562.Emtol_2448	5.57e-08	56.2	COG1595@1|root,COG1595@2|Bacteria,4NQCY@976|Bacteroidetes,47QYA@768503|Cytophagia	976|Bacteroidetes	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_484560_2	159087.Daro_1044	7.48e-13	72.0	COG4772@1|root,COG4772@2|Bacteria,1MUIH@1224|Proteobacteria,2VKC9@28216|Betaproteobacteria,2KVU2@206389|Rhodocyclales	206389|Rhodocyclales	P	COG1629 Outer membrane receptor proteins, mostly Fe transport	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k59_1427398_1	1449058.JQKT01000007_gene1026	2.87e-05	51.2	COG3480@1|root,COG3480@2|Bacteria,2GJDD@201174|Actinobacteria,4FK7Z@85023|Microbacteriaceae	201174|Actinobacteria	T	Lon protease (S16) C-terminal proteolytic domain	ylbL	-	-	ko:K07177	ko02024,map02024	-	-	-	ko00000,ko00001,ko01002	-	-	-	Lon_C,PDZ_2
k59_1483890_1	1121878.AUGL01000031_gene3522	2.35e-85	269.0	COG1164@1|root,COG1164@2|Bacteria,1MWYN@1224|Proteobacteria,1RS2Q@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	PFAM peptidase M2, peptidyl-dipeptidase A	-	-	3.4.15.1	ko:K01283	ko04614,ko04924,ko05142,ko05410,map04614,map04924,map05142,map05410	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	Peptidase_M2
k59_1594903_1	1380390.JIAT01000009_gene2164	2.97e-42	152.0	COG4799@1|root,COG4799@2|Bacteria,2GIRU@201174|Actinobacteria,4CPHH@84995|Rubrobacteria	84995|Rubrobacteria	I	Carboxyl transferase domain	-	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_1594903_2	944479.JQLX01000013_gene1447	6.95e-17	79.7	COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,42M14@68525|delta/epsilon subdivisions,2WIN7@28221|Deltaproteobacteria,2M6KR@213113|Desulfurellales	28221|Deltaproteobacteria	I	Biotin carboxylase C-terminal domain	pccA	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
k59_36925_1	641107.CDLVIII_2336	5.04e-50	172.0	COG1914@1|root,COG1914@2|Bacteria,1TPT1@1239|Firmicutes,24ACU@186801|Clostridia,36E5S@31979|Clostridiaceae	186801|Clostridia	P	PFAM natural resistance-associated macrophage protein	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
k59_537949_1	886293.Sinac_7422	4.52e-88	273.0	COG3344@1|root,COG3344@2|Bacteria,2IZGP@203682|Planctomycetes	203682|Planctomycetes	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	2.7.7.49	ko:K00986	-	-	-	-	ko00000,ko01000	-	-	-	GIIM,RVT_1
k59_92992_2	1200557.JHWV01000005_gene1586	0.00047	42.4	COG3608@1|root,COG3608@2|Bacteria,1TRKT@1239|Firmicutes,4H2QT@909932|Negativicutes	909932|Negativicutes	S	Selenium-dependent molybdenum hydroxylase system protein, YqeB family	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	-
k59_815889_2	216142.LT40_07935	2.03e-06	50.4	COG4964@1|root,COG4964@2|Bacteria,1MV8G@1224|Proteobacteria,1RQ4U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	Belongs to the GSP D family	rcpA	-	-	ko:K02280	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	BON,Secretin,T2SS-T3SS_pil_N
k59_1594945_1	887929.HMP0721_1080	1.7e-42	155.0	COG2239@1|root,COG2239@2|Bacteria,1TP4V@1239|Firmicutes,2481R@186801|Clostridia,25VPU@186806|Eubacteriaceae	186801|Clostridia	P	Acts as a magnesium transporter	mgtE	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
k59_1152309_1	941449.dsx2_2317	1.87e-13	75.5	COG0642@1|root,COG2205@2|Bacteria,1MUZQ@1224|Proteobacteria,42NZF@68525|delta/epsilon subdivisions,2WJNR@28221|Deltaproteobacteria,2MAHW@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Osmosensitive K channel His kinase sensor	kdpD	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,GAF_3,HATPase_c,HisKA,KdpD,Usp
k59_1429370_1	926569.ANT_11950	6.31e-118	357.0	COG0646@1|root,COG0685@1|root,COG0646@2|Bacteria,COG0685@2|Bacteria,2G674@200795|Chloroflexi	200795|Chloroflexi	H	Homocysteine S-methyltransferase	-	-	1.5.1.20,2.1.1.10	ko:K00297,ko:K00547	ko00270,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01523,map00270,map00670,map00720,map01100,map01110,map01120,map01200,map01523	M00377	R00650,R01224,R07168	RC00003,RC00035,RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR,S-methyl_trans
k59_486364_2	1500897.JQNA01000002_gene2297	2.74e-48	165.0	COG2084@1|root,COG2084@2|Bacteria,1P0X0@1224|Proteobacteria,2VS06@28216|Betaproteobacteria,1K1QA@119060|Burkholderiaceae	28216|Betaproteobacteria	I	6-phosphogluconate dehydrogenase, NAD-binding	-	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
k59_1649880_1	379066.GAU_0925	3.93e-88	282.0	COG1198@1|root,COG1198@2|Bacteria,1ZTE9@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C
k59_1374574_1	1192868.CAIU01000009_gene1243	4.52e-65	217.0	COG3108@1|root,COG3108@2|Bacteria,1MWW2@1224|Proteobacteria,2TQZ1@28211|Alphaproteobacteria,43GYS@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	PFAM Bacterial protein of	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M15_2
k59_486387_1	319003.Bra1253DRAFT_01580	2.09e-53	185.0	COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,2TR28@28211|Alphaproteobacteria,3JUNN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ptsI	-	2.7.3.9	ko:K08483	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
k59_1596874_1	1121403.AUCV01000024_gene3444	2.02e-61	201.0	COG4260@1|root,COG4260@2|Bacteria,1MXTD@1224|Proteobacteria,42P7D@68525|delta/epsilon subdivisions,2WJ6S@28221|Deltaproteobacteria,2MIXK@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM SPFH domain Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7_1,DZR,SHOCT,zinc_ribbon_2
k59_1649908_1	190650.CC_3086	5.47e-14	76.6	COG1680@1|root,COG1680@2|Bacteria,1MVZN@1224|Proteobacteria,2V9NS@28211|Alphaproteobacteria,2KF0W@204458|Caulobacterales	204458|Caulobacterales	V	PFAM Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,DUF3471
k59_986374_2	68194.JNXR01000041_gene6458	1.16e-06	49.7	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_373024_1	1415755.JQLV01000001_gene3629	1.69e-16	79.3	COG0596@1|root,COG0596@2|Bacteria,1MVTG@1224|Proteobacteria,1RQ1B@1236|Gammaproteobacteria,1XM9K@135619|Oceanospirillales	135619|Oceanospirillales	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
k59_1709271_1	318586.Pden_1650	3.08e-16	78.2	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,2TQYV@28211|Alphaproteobacteria,2PVME@265|Paracoccus	28211|Alphaproteobacteria	IQ	catalyzes a condensation reaction in fatty acid biosynthesis addition of an acyl acceptor of two carbons from malonyl-ACP	fabB	GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.41	ko:K00647	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_1709271_2	393595.ABO_0835	1.66e-43	146.0	COG0764@1|root,COG0764@2|Bacteria,1MWV8@1224|Proteobacteria,1RP6W@1236|Gammaproteobacteria,1XHB3@135619|Oceanospirillales	135619|Oceanospirillales	I	Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length	fabA	-	4.2.1.59,5.3.3.14	ko:K01716	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00083	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07639	RC00831,RC01078,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
k59_1485881_1	926556.Echvi_1560	1.11e-65	224.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,4NGU2@976|Bacteroidetes,47KCJ@768503|Cytophagia	976|Bacteroidetes	M	Tricorn protease homolog	-	-	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
k59_1319863_1	438753.AZC_4431	6.67e-16	76.6	COG1595@1|root,COG1595@2|Bacteria,1RHYH@1224|Proteobacteria,2VFIS@28211|Alphaproteobacteria,3F1DJ@335928|Xanthobacteraceae	28211|Alphaproteobacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_318904_1	880073.Calab_3293	1.76e-55	189.0	COG3829@1|root,COG3829@2|Bacteria,2NQNU@2323|unclassified Bacteria	2|Bacteria	KT	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HTH_8,Sigma54_activat
k59_1429444_1	1487953.JMKF01000057_gene4392	1.06e-70	234.0	COG0480@1|root,COG0480@2|Bacteria,1G1KG@1117|Cyanobacteria,1H7SY@1150|Oscillatoriales	1117|Cyanobacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_1709294_1	314230.DSM3645_12706	2.53e-55	178.0	COG3576@1|root,COG3576@2|Bacteria,2IZI0@203682|Planctomycetes	203682|Planctomycetes	S	Pfam:Pyridox_oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
k59_1709294_2	870187.Thini_1466	1.15e-38	132.0	COG3791@1|root,COG3791@2|Bacteria,1REMP@1224|Proteobacteria,1SXS7@1236|Gammaproteobacteria,462ZE@72273|Thiotrichales	72273|Thiotrichales	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
k59_1539773_1	1379270.AUXF01000002_gene1182	9.65e-82	247.0	COG0035@1|root,COG0035@2|Bacteria,1ZT1C@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate	upp	-	2.4.2.9	ko:K00761	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000	-	-	-	UPRTase
k59_817857_1	861299.J421_3410	6.7e-84	254.0	COG0528@1|root,COG0528@2|Bacteria,1ZSY2@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
k59_594978_1	279238.Saro_2609	2.99e-76	245.0	COG0174@1|root,COG0174@2|Bacteria,1MU6V@1224|Proteobacteria,2U0Z2@28211|Alphaproteobacteria,2KCZZ@204457|Sphingomonadales	204457|Sphingomonadales	E	Glutamine synthetase, catalytic domain	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
k59_1042747_1	1333998.M2A_2935	2.37e-43	156.0	COG0520@1|root,COG0520@2|Bacteria,1QU0N@1224|Proteobacteria,2TW6K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	aminotransferase class V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
k59_1761328_1	1125863.JAFN01000001_gene2574	3.24e-16	80.1	COG0704@1|root,COG0704@2|Bacteria,1NRGK@1224|Proteobacteria	1224|Proteobacteria	P	PhoU domain	-	-	-	-	-	-	-	-	-	-	-	-	PhoU
k59_708079_1	926569.ANT_27630	4.74e-23	90.9	COG2920@1|root,COG2920@2|Bacteria,2G9BI@200795|Chloroflexi	200795|Chloroflexi	P	DsrC like protein	dsrC	-	-	ko:K11179	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DsrC
k59_649289_1	105422.BBPM01000048_gene1641	5.06e-55	176.0	COG1720@1|root,COG1720@2|Bacteria,2IKKT@201174|Actinobacteria,2NIXH@228398|Streptacidiphilus	201174|Actinobacteria	S	Uncharacterised protein family UPF0066	-	-	-	-	-	-	-	-	-	-	-	-	UPF0066
k59_1374678_1	521098.Aaci_1840	1.39e-42	154.0	COG0373@1|root,COG0373@2|Bacteria,1TQN9@1239|Firmicutes,4HAVC@91061|Bacilli,2788S@186823|Alicyclobacillaceae	91061|Bacilli	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS08420	GlutR_N,GlutR_dimer,Shikimate_DH
k59_649307_1	1408473.JHXO01000006_gene1123	2.35e-67	229.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,4NGU2@976|Bacteroidetes,2FPGA@200643|Bacteroidia	976|Bacteroidetes	M	Tricorn protease homolog	-	-	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
k59_1152423_1	1206737.BAGF01000081_gene5267	1.88e-15	74.3	2EGCD@1|root,33A46@2|Bacteria,2GR1I@201174|Actinobacteria,4G2WY@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4190
k59_986455_1	666684.AfiDRAFT_1567	1.08e-07	58.5	COG0642@1|root,COG2205@2|Bacteria,1N1Z2@1224|Proteobacteria,2U2VX@28211|Alphaproteobacteria,3K5XZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K07649	ko02020,map02020	M00457	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	2CSK_N,HATPase_c,HisKA
k59_1429497_1	570967.JMLV01000002_gene1560	4.3e-23	102.0	COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,2U35U@28211|Alphaproteobacteria,2JQXV@204441|Rhodospirillales	204441|Rhodospirillales	M	COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)	-	-	-	-	-	-	-	-	-	-	-	-	SLT
k59_318968_1	765910.MARPU_03780	7.55e-40	136.0	COG0094@1|root,COG0094@2|Bacteria,1MUU9@1224|Proteobacteria,1RPE1@1236|Gammaproteobacteria,1WW32@135613|Chromatiales	135613|Chromatiales	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	-	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
k59_318968_2	556269.ACDQ01000019_gene757	9.99e-31	111.0	COG0199@1|root,COG0199@2|Bacteria,1MZDT@1224|Proteobacteria,2VSVX@28216|Betaproteobacteria,474KT@75682|Oxalobacteraceae	28216|Betaproteobacteria	J	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site	rpsN	-	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
k59_373123_1	1121921.KB898706_gene3345	8.13e-22	89.7	COG0594@1|root,COG0594@2|Bacteria,1MZQE@1224|Proteobacteria,1S90M@1236|Gammaproteobacteria,2PNR1@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	J	Ribonuclease P	rnpA	GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005655,GO:0005730,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0030681,GO:0031974,GO:0031981,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044452,GO:0044464,GO:0046483,GO:0070013,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1902555,GO:1905348,GO:1990904	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
k59_318977_1	196162.Noca_2329	8.63e-51	186.0	COG1201@1|root,COG1201@2|Bacteria,2GJG3@201174|Actinobacteria,4DPDX@85009|Propionibacteriales	201174|Actinobacteria	L	DEAD/H associated	lhr	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,HTH_42,Helicase_C
k59_1042809_1	749927.AMED_5774	8.78e-11	67.8	COG3387@1|root,COG3387@2|Bacteria,2I774@201174|Actinobacteria,4EAE0@85010|Pseudonocardiales	201174|Actinobacteria	G	Bacterial alpha-L-rhamnosidase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Bac_rhamnosid6H,Bac_rhamnosid_C
k59_708154_1	1207063.P24_08719	1.6e-73	228.0	COG0778@1|root,COG0778@2|Bacteria,1PG8V@1224|Proteobacteria,2U59W@28211|Alphaproteobacteria,2JSC8@204441|Rhodospirillales	204441|Rhodospirillales	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
k59_708154_2	1297863.APJF01000030_gene825	1.35e-09	58.9	COG0583@1|root,COG0583@2|Bacteria,1MWY0@1224|Proteobacteria,2TSD9@28211|Alphaproteobacteria,3K2PW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	LysR substrate binding domain	-	-	-	ko:K03566	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_1,LysR_substrate
k59_1650059_1	983545.Glaag_3436	7.63e-34	130.0	COG0129@1|root,COG0129@2|Bacteria,1MU3T@1224|Proteobacteria,1RMNA@1236|Gammaproteobacteria,464QM@72275|Alteromonadaceae	1236|Gammaproteobacteria	EG	Belongs to the IlvD Edd family	edd	GO:0003674,GO:0003824,GO:0004456,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019520,GO:0019521,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0046176,GO:0046177,GO:0046395,GO:0071704,GO:0072329,GO:1901575	4.2.1.12	ko:K01690	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00008	R02036	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	iEcolC_1368.EcolC_1781,iJN746.PP_1010,iPC815.YPO2533,iYL1228.KPN_02366	ILVD_EDD
k59_1650059_2	667121.ET1_03_01150	8.36e-10	59.3	COG0800@1|root,COG0800@2|Bacteria,1MUVJ@1224|Proteobacteria,1RPDF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Aldolase	eda	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008675,GO:0008700,GO:0008948,GO:0016829,GO:0016830,GO:0016831,GO:0016832,GO:0016833,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0106009	4.1.2.14,4.1.3.42	ko:K01625	ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200	M00008,M00061,M00308,M00631	R00470,R05605	RC00307,RC00308,RC00435	ko00000,ko00001,ko00002,ko01000	-	-	iECOK1_1307.ECOK1_1968,iYL1228.KPN_02365	Aldolase
k59_1111786_1	926569.ANT_20420	1.99e-38	147.0	COG1197@1|root,COG1197@2|Bacteria,2G5UW@200795|Chloroflexi	200795|Chloroflexi	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_1778058_1	768710.DesyoDRAFT_4308	7.02e-49	177.0	COG0458@1|root,COG0458@2|Bacteria,1TPID@1239|Firmicutes,24819@186801|Clostridia,260WM@186807|Peptococcaceae	186801|Clostridia	EF	Belongs to the CarB family	carB2	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_1111797_1	936136.ARRT01000006_gene2184	7.31e-20	93.6	COG3710@1|root,COG3903@1|root,COG3710@2|Bacteria,COG3903@2|Bacteria,1MWPD@1224|Proteobacteria,2TQQR@28211|Alphaproteobacteria,4BAW7@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	NB-ARC,Trans_reg_C
k59_109434_1	105422.BBPM01000003_gene5688	7.17e-100	307.0	COG0520@1|root,COG0520@2|Bacteria,2IAKT@201174|Actinobacteria,2NGTH@228398|Streptacidiphilus	201174|Actinobacteria	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
k59_53534_1	886293.Sinac_5868	9.73e-28	113.0	COG3386@1|root,COG3386@2|Bacteria,2IXZT@203682|Planctomycetes	203682|Planctomycetes	G	gluconolactonase	-	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	SGL
k59_1220674_1	1536773.R70331_13305	3e-64	203.0	COG0176@1|root,COG0176@2|Bacteria,1TP4Q@1239|Firmicutes,4HA8G@91061|Bacilli,26RN0@186822|Paenibacillaceae	91061|Bacilli	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
k59_1220674_2	671143.DAMO_2288	4.68e-14	70.5	COG1414@1|root,COG1414@2|Bacteria,2NR17@2323|unclassified Bacteria	2|Bacteria	K	helix_turn_helix isocitrate lyase regulation	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
k59_1111844_1	1123229.AUBC01000005_gene591	1.97e-19	91.7	COG3181@1|root,COG3181@2|Bacteria,1MWVK@1224|Proteobacteria,2TXW7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_607996_1	1122927.KB895419_gene2506	1.23e-21	99.8	COG1680@1|root,COG1680@2|Bacteria,1UZZ5@1239|Firmicutes,4HA1I@91061|Bacilli,272U5@186822|Paenibacillaceae	91061|Bacilli	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_1444806_1	517417.Cpar_0427	4.02e-63	200.0	COG0528@1|root,COG0528@2|Bacteria,1FD6T@1090|Chlorobi	1090|Chlorobi	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
k59_1444806_2	1379270.AUXF01000006_gene122	2.98e-27	104.0	COG0233@1|root,COG0233@2|Bacteria,1ZTI2@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	-	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
k59_1611565_2	926550.CLDAP_30500	1.43e-23	92.4	COG0425@1|root,COG0425@2|Bacteria,2G7DF@200795|Chloroflexi	200795|Chloroflexi	O	Belongs to the sulfur carrier protein TusA family	-	-	-	-	-	-	-	-	-	-	-	-	TusA
k59_1611565_3	926550.CLDAP_30490	1.37e-29	112.0	COG2210@1|root,COG2210@2|Bacteria,2G77F@200795|Chloroflexi	200795|Chloroflexi	S	DsrE/DsrF/DrsH-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2
k59_217735_1	207559.Dde_2363	6.91e-87	272.0	COG4962@1|root,COG4962@2|Bacteria,1R7EN@1224|Proteobacteria,42NAK@68525|delta/epsilon subdivisions,2WIYX@28221|Deltaproteobacteria,2M8UJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	U	PFAM Type II secretion system protein E	-	-	-	ko:K02283,ko:K03609	-	-	-	-	ko00000,ko02035,ko02044,ko03036,ko04812	-	-	-	CbiA,FHA,T2SSE
k59_1113373_1	1123060.JONP01000033_gene1899	1.15e-56	191.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TRYI@28211|Alphaproteobacteria,2JPKJ@204441|Rhodospirillales	204441|Rhodospirillales	C	COG0277 FAD FMN-containing dehydrogenases	-	-	1.1.2.4	ko:K00102	ko00620,map00620	-	R00197	RC00044	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_1669212_1	290397.Adeh_1592	5.05e-123	387.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,43DMZ@68525|delta/epsilon subdivisions,2WIW5@28221|Deltaproteobacteria,2YUEA@29|Myxococcales	28221|Deltaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_1168887_1	1449126.JQKL01000023_gene191	2.09e-16	78.6	COG3707@1|root,COG3707@2|Bacteria,1U6TA@1239|Firmicutes,24G9P@186801|Clostridia,268M1@186813|unclassified Clostridiales	186801|Clostridia	T	ANTAR	-	-	-	ko:K22010	-	M00839	-	-	ko00000,ko00002,ko02022	-	-	-	ANTAR,Response_reg
k59_1168887_2	273063.STK_14710	1.31e-15	72.4	COG0537@1|root,arCOG00419@2157|Archaea,2XQZ7@28889|Crenarchaeota	28889|Crenarchaeota	F	PFAM histidine triad (HIT) protein	-	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
k59_57029_1	1236959.BAMT01000001_gene1431	1.14e-88	268.0	COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,2WGGJ@28216|Betaproteobacteria,2KM6H@206350|Nitrosomonadales	206350|Nitrosomonadales	E	Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide	metZ	-	-	ko:K10764	ko00270,ko00920,ko01100,map00270,map00920,map01100	-	R01288	RC00020,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
k59_112569_1	316067.Geob_1632	4.53e-25	110.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MRH@68525|delta/epsilon subdivisions,2WM8D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase HAMP	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,sCache_3_3
k59_668571_1	1379270.AUXF01000002_gene1585	5.75e-64	218.0	COG0515@1|root,COG0515@2|Bacteria,1ZUMJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
k59_57031_1	1502851.FG93_06058	1.19e-51	171.0	COG1126@1|root,COG1126@2|Bacteria,1MU9Q@1224|Proteobacteria,2TQX2@28211|Alphaproteobacteria,3JUA8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	ABC transporter	aapP	-	3.6.3.21	ko:K02028,ko:K09972	ko02010,map02010	M00232,M00236	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3,3.A.1.3.17,3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	ABC_tran
k59_57031_2	1156919.QWC_02963	2.82e-14	72.4	COG0765@1|root,COG0765@2|Bacteria,1MV3I@1224|Proteobacteria,2VIXA@28216|Betaproteobacteria,3T32V@506|Alcaligenaceae	28216|Betaproteobacteria	P	ABC-type amino acid transport system permease component	aapM	-	-	ko:K09971	ko02010,map02010	M00232	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	BPD_transp_1
k59_223753_1	1298858.AUEL01000016_gene2495	5.24e-57	188.0	COG0491@1|root,COG0491@2|Bacteria,1N1ZW@1224|Proteobacteria,2TUMN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_390600_1	604331.AUHY01000015_gene2647	4.69e-07	57.0	COG0308@1|root,COG0823@1|root,COG2831@1|root,COG0308@2|Bacteria,COG0823@2|Bacteria,COG2831@2|Bacteria	2|Bacteria	U	hemolysin activation secretion protein	hxuB	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,POTRA_2,ShlB
k59_1280122_1	485913.Krac_9327	4.34e-28	115.0	COG3547@1|root,COG3547@2|Bacteria	2|Bacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1168900_1	519989.ECTPHS_01134	1.27e-108	338.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,1WWWP@135613|Chromatiales	135613|Chromatiales	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topo_Zn_Ribbon,Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom
k59_1724814_1	1170562.Cal6303_3342	7.28e-123	360.0	COG3039@1|root,COG3039@2|Bacteria,1GJCG@1117|Cyanobacteria,1HRHR@1161|Nostocales	1117|Cyanobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_779735_1	1097668.BYI23_B010690	2.23e-13	69.7	COG1715@1|root,COG1715@2|Bacteria,1Q2VY@1224|Proteobacteria,2VPK0@28216|Betaproteobacteria,1K9HQ@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Mrr N-terminal domain	-	-	-	ko:K07448	-	-	-	-	ko00000,ko02048	-	-	-	Mrr_N,Mrr_cat
k59_1483_2	289377.HL41_05080	1.78e-10	63.2	COG0750@1|root,COG0750@2|Bacteria,2GGSW@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	M	Peptidase family M50	-	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_M50
k59_946557_2	357808.RoseRS_1075	2.93e-14	75.1	COG0577@1|root,COG0577@2|Bacteria,2G68F@200795|Chloroflexi,376ZY@32061|Chloroflexia	32061|Chloroflexia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_446228_1	926569.ANT_22630	1.42e-37	143.0	COG1086@1|root,COG2148@1|root,COG1086@2|Bacteria,COG2148@2|Bacteria,2G6DJ@200795|Chloroflexi	200795|Chloroflexi	M	Bacterial sugar transferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
k59_1280140_2	1123060.JONP01000028_gene3705	1.77e-80	249.0	COG1960@1|root,COG1960@2|Bacteria,1MX17@1224|Proteobacteria,2TTRE@28211|Alphaproteobacteria,2JV80@204441|Rhodospirillales	204441|Rhodospirillales	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_557325_1	1265505.ATUG01000003_gene541	5.7e-25	105.0	COG0702@1|root,COG0702@2|Bacteria,1PDTN@1224|Proteobacteria,42M8X@68525|delta/epsilon subdivisions,2WJ5J@28221|Deltaproteobacteria,2MHQP@213118|Desulfobacterales	28221|Deltaproteobacteria	GM	Protein of unknown function (DUF2867)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2867,NAD_binding_10
k59_557325_2	518766.Rmar_1606	5.02e-39	143.0	COG0702@1|root,COG0702@2|Bacteria,4NEJF@976|Bacteroidetes,1FIWH@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	GM	Protein of unknown function (DUF2867)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2867,Epimerase,NAD_binding_10
k59_279346_1	1267533.KB906736_gene1021	1.02e-12	73.2	COG0577@1|root,COG0577@2|Bacteria,3Y44G@57723|Acidobacteria,2JHKI@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_724254_1	1304878.AUGD01000002_gene1447	4.58e-18	82.8	COG0216@1|root,COG0216@2|Bacteria,1R347@1224|Proteobacteria,2TZXU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	RF-1 domain	-	-	-	-	-	-	-	-	-	-	-	-	RF-1
k59_1391332_1	926550.CLDAP_19780	1.72e-100	300.0	COG0685@1|root,COG0685@2|Bacteria,2G7NU@200795|Chloroflexi	200795|Chloroflexi	C	PFAM Methylenetetrahydrofolate reductase	-	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
k59_668626_1	1123355.JHYO01000014_gene986	1.57e-25	101.0	COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,2TRD9@28211|Alphaproteobacteria,36XAI@31993|Methylocystaceae	28211|Alphaproteobacteria	J	Ribosomal RNA adenine dimethylases	ksgA	GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
k59_668626_2	388399.SSE37_08188	5.39e-56	186.0	COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,2TSKF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)	pdxA	-	1.1.1.262	ko:K00097	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxA
k59_390644_1	861299.J421_4361	2.37e-12	67.4	COG1321@1|root,COG1918@1|root,COG1321@2|Bacteria,COG1918@2|Bacteria,1ZTHJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Helix-turn-helix diphteria tox regulatory element	-	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA
k59_390644_2	1117943.SFHH103_00583	1.09e-13	73.2	COG3175@1|root,COG3175@2|Bacteria,1RDTU@1224|Proteobacteria,2U6ZT@28211|Alphaproteobacteria,4BA7C@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I	ctaG	-	-	ko:K02258	ko00190,ko01100,ko04714,map00190,map01100,map04714	M00154	-	-	ko00000,ko00001,ko00002,ko03029	3.D.4.8	-	-	CtaG_Cox11
k59_1391342_1	479434.Sthe_1585	3.51e-15	71.2	2EKS3@1|root,33EFV@2|Bacteria,2GBBM@200795|Chloroflexi,27YP9@189775|Thermomicrobia	189775|Thermomicrobia	S	Prokaryotic Cytochrome C oxidase subunit IV	-	-	1.9.3.1	ko:K02277	ko00190,ko01100,map00190,map01100	M00155	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.4	-	-	COX4_pro
k59_1391342_2	926690.KE386573_gene116	1.41e-44	158.0	COG1232@1|root,arCOG01522@2157|Archaea,2XT3Z@28890|Euryarchaeota,23TW5@183963|Halobacteria	183963|Halobacteria	H	protoporphyrinogen oxidase	-	-	1.3.3.15,1.3.3.4	ko:K00231	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03222,R04178	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
k59_1057731_1	314285.KT71_11675	2.24e-107	335.0	COG3544@1|root,COG3544@2|Bacteria,1NTI3@1224|Proteobacteria,1T0HG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4142)	-	-	-	-	-	-	-	-	-	-	-	-	DUF305
k59_724271_1	1121904.ARBP01000013_gene459	2.41e-09	58.5	28NN4@1|root,2ZBNJ@2|Bacteria,4NMVI@976|Bacteroidetes,47PGF@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_501797_1	118163.Ple7327_0754	3.78e-70	224.0	COG3842@1|root,COG3842@2|Bacteria,1G1HQ@1117|Cyanobacteria,3VNJQ@52604|Pleurocapsales	1117|Cyanobacteria	E	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	potA	-	3.6.3.31	ko:K02052,ko:K11072	ko02010,ko02024,map02010,map02024	M00193,M00299	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.11,3.A.1.11.1	-	-	ABC_tran,TOBE_2
k59_1057737_1	448385.sce8624	1.09e-22	97.4	COG0318@1|root,COG0318@2|Bacteria,1QXPD@1224|Proteobacteria,43C59@68525|delta/epsilon subdivisions,2WRV5@28221|Deltaproteobacteria,2Z0SY@29|Myxococcales	28221|Deltaproteobacteria	IQ	Acyl-protein synthetase, LuxE	-	-	-	-	-	-	-	-	-	-	-	-	LuxE
k59_223812_1	1267533.KB906737_gene1705	4.48e-09	62.8	COG0348@1|root,COG3336@1|root,COG0348@2|Bacteria,COG3336@2|Bacteria,3Y3CM@57723|Acidobacteria,2JMJA@204432|Acidobacteriia	204432|Acidobacteriia	C	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG)	-	-	-	-	-	-	-	-	-	-	-	-	Caa3_CtaG
k59_613000_1	35754.JNYJ01000089_gene6366	1.42e-58	196.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,2GN50@201174|Actinobacteria,4DBXF@85008|Micromonosporales	201174|Actinobacteria	P	Rhodanese domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,Rhodanese
k59_1168972_2	1150469.RSPPHO_02402	4.17e-27	103.0	COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,2U591@28211|Alphaproteobacteria,2JRWJ@204441|Rhodospirillales	204441|Rhodospirillales	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	Pro_isomerase
k59_1502528_1	379066.GAU_2204	3.37e-49	179.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
k59_223834_1	1089552.KI911559_gene3479	8.37e-59	198.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TR1D@28211|Alphaproteobacteria,2JRBI@204441|Rhodospirillales	204441|Rhodospirillales	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_1391384_1	504472.Slin_1343	6.49e-72	236.0	COG2382@1|root,COG2382@2|Bacteria,4NGBK@976|Bacteroidetes,47K7D@768503|Cytophagia	976|Bacteroidetes	P	esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
k59_57124_1	1131814.JAFO01000001_gene27	1.72e-51	184.0	COG0045@1|root,COG0454@1|root,COG1042@1|root,COG0045@2|Bacteria,COG0456@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2TR24@28211|Alphaproteobacteria,3F0K6@335928|Xanthobacteraceae	28211|Alphaproteobacteria	CK	CoA-binding domain protein	yfiQ	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
k59_279409_1	357808.RoseRS_0488	5.59e-67	218.0	COG0499@1|root,COG0499@2|Bacteria,2G5X8@200795|Chloroflexi,3758U@32061|Chloroflexia	32061|Chloroflexia	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
k59_1391386_1	1121468.AUBR01000012_gene2593	4.38e-93	290.0	COG0365@1|root,COG0365@2|Bacteria,1UMN9@1239|Firmicutes,25GME@186801|Clostridia	186801|Clostridia	I	AMP-binding enzyme C-terminal domain	-	-	6.2.1.32	ko:K08295	ko00627,ko01120,map00627,map01120	-	R00982	RC00004,RC00174	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C
k59_1391395_2	745014.OMB55_00021400	1.38e-09	58.2	COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,1RR3Z@1236|Gammaproteobacteria,1J50U@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	paaF	-	-	-	-	-	-	-	-	-	-	-	ECH_1
k59_1335794_1	83406.HDN1F_25480	1.17e-07	58.5	COG2866@1|root,COG2866@2|Bacteria,1PE32@1224|Proteobacteria,1TBWG@1236|Gammaproteobacteria,1JBBW@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Zinc carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
k59_668690_1	1463857.JOFZ01000006_gene3491	4.24e-68	220.0	COG0114@1|root,COG0114@2|Bacteria,2GKWY@201174|Actinobacteria	201174|Actinobacteria	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	GO:0003674,GO:0003824,GO:0004333,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006106,GO:0006108,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019752,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0071944,GO:0072350	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
k59_501846_1	998674.ATTE01000001_gene4315	4.45e-19	92.0	COG2304@1|root,COG2304@2|Bacteria,1MW51@1224|Proteobacteria,1RMD3@1236|Gammaproteobacteria,460CJ@72273|Thiotrichales	72273|Thiotrichales	S	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	BatA,TPR_1,TPR_2,VWA_2
k59_335037_1	1122135.KB893142_gene25	1.7e-117	348.0	COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,2TQVF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase	rarA	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
k59_1558185_1	404589.Anae109_4238	3.38e-42	141.0	COG2030@1|root,COG2030@2|Bacteria,1RJN8@1224|Proteobacteria	1224|Proteobacteria	I	dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
k59_779850_1	1282360.ABAC460_10435	8.61e-15	80.9	COG3710@1|root,COG3710@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Abhydrolase_1,Trans_reg_C
k59_946670_1	926550.CLDAP_17390	7.88e-110	338.0	COG0008@1|root,COG0064@1|root,COG0008@2|Bacteria,COG0064@2|Bacteria,2G827@200795|Chloroflexi	200795|Chloroflexi	J	tRNA synthetases class I (E and Q), anti-codon binding domain	glnS	-	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
k59_1724929_1	1173020.Cha6605_3860	2.91e-08	59.7	COG2433@1|root,COG2433@2|Bacteria,1G2BH@1117|Cyanobacteria	1117|Cyanobacteria	P	PFAM transposase IS66	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,zf-IS66
k59_668714_1	1340493.JNIF01000003_gene3309	1.82e-38	141.0	COG1260@1|root,COG1260@2|Bacteria,3Y325@57723|Acidobacteria	57723|Acidobacteria	I	Myo-inositol-1-phosphate synthase, GAPDH domain protein	-	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth,NAD_binding_5
k59_292356_1	383372.Rcas_2852	5.5e-21	95.1	COG0010@1|root,COG0010@2|Bacteria,2G8DY@200795|Chloroflexi	200795|Chloroflexi	E	Belongs to the arginase family	-	-	3.5.3.1	ko:K01476	ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146	M00029,M00134	R00551	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
k59_403332_1	671143.DAMO_2989	5.08e-125	364.0	COG1702@1|root,COG1702@2|Bacteria,2NNZF@2323|unclassified Bacteria	2|Bacteria	T	PhoH-like protein	phoH	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
k59_1348302_1	1120956.JHZK01000034_gene2045	4.74e-59	196.0	COG2241@1|root,COG2242@1|root,COG2241@2|Bacteria,COG2242@2|Bacteria,1MVJX@1224|Proteobacteria,2TRR5@28211|Alphaproteobacteria,1JPUJ@119043|Rhodobiaceae	28211|Alphaproteobacteria	H	Tetrapyrrole (Corrin/Porphyrin) Methylases	cobL	-	2.1.1.132	ko:K00595	ko00860,ko01100,map00860,map01100	-	R05149	RC00003,RC01279	ko00000,ko00001,ko01000	-	-	-	PCMT,TP_methylase
k59_1681916_1	1304865.JAGF01000001_gene3492	2.47e-60	201.0	COG2132@1|root,COG2132@2|Bacteria,2IDXQ@201174|Actinobacteria	201174|Actinobacteria	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase_3
k59_180654_1	1321782.HMPREF1986_01793	4.41e-05	50.8	COG0515@1|root,COG0515@2|Bacteria,1TP3F@1239|Firmicutes,2492G@186801|Clostridia,2PRP0@265975|Oribacterium	186801|Clostridia	KLT	Kinase domain protein	prkC	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
k59_569735_1	1123355.JHYO01000007_gene444	3.12e-06	53.5	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,2TQZE@28211|Alphaproteobacteria,36YA9@31993|Methylocystaceae	28211|Alphaproteobacteria	M	Peptidase family M23	MA20_30780	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_14387_1	83406.HDN1F_37140	1.14e-77	244.0	COG0044@1|root,COG0044@2|Bacteria,1MVXY@1224|Proteobacteria,1T03U@1236|Gammaproteobacteria,1J8GA@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Amidohydrolase family	pyrC	-	3.5.2.3,3.5.2.5	ko:K01465,ko:K01466	ko00230,ko00240,ko01100,ko01120,map00230,map00240,map01100,map01120	M00051,M00546	R01993,R02425	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
k59_849371_1	555779.Dthio_PD0884	6.17e-65	214.0	COG0733@1|root,COG0733@2|Bacteria,1MUZJ@1224|Proteobacteria,42M3J@68525|delta/epsilon subdivisions,2WJZA@28221|Deltaproteobacteria,2M8NB@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Sodium:neurotransmitter symporter family	-	-	-	ko:K03308	-	-	-	-	ko00000	2.A.22.4,2.A.22.5	-	-	SNF
k59_1183635_1	438753.AZC_2815	2.31e-112	349.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,2TS9E@28211|Alphaproteobacteria,3EYP7@335928|Xanthobacteraceae	28211|Alphaproteobacteria	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
k59_684013_1	452637.Oter_2142	4.14e-25	103.0	COG0446@1|root,COG0446@2|Bacteria	2|Bacteria	Q	pyridine nucleotide-disulphide oxidoreductase	-	-	1.7.1.15	ko:K00362	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	AIF_C,Pyr_redox_2
k59_182498_1	42254.XP_004603831.1	9.5e-18	82.4	COG0104@1|root,KOG1922@1|root,KOG1355@2759|Eukaryota,KOG1922@2759|Eukaryota,38HVH@33154|Opisthokonta,3BCDJ@33208|Metazoa,3CTAB@33213|Bilateria,481SY@7711|Chordata,49H6C@7742|Vertebrata,3J5E3@40674|Mammalia	33208|Metazoa	F	adenylosuccinate synthase activity	ADSSL1	GO:0000166,GO:0001882,GO:0001883,GO:0002376,GO:0003674,GO:0003779,GO:0003824,GO:0003924,GO:0004019,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006520,GO:0006531,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0007275,GO:0007517,GO:0007519,GO:0008092,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009888,GO:0009987,GO:0014706,GO:0014902,GO:0014904,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016874,GO:0016879,GO:0017076,GO:0017111,GO:0017144,GO:0018130,GO:0019001,GO:0019438,GO:0019637,GO:0019693,GO:0019725,GO:0019752,GO:0030154,GO:0032501,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042301,GO:0042592,GO:0042692,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0046716,GO:0046983,GO:0048468,GO:0048513,GO:0048731,GO:0048741,GO:0048747,GO:0048856,GO:0048869,GO:0051015,GO:0051146,GO:0055001,GO:0055002,GO:0055086,GO:0060249,GO:0060537,GO:0060538,GO:0061061,GO:0065007,GO:0065008,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
k59_182498_2	272123.Anacy_0025	1.02e-17	86.3	COG1052@1|root,COG1052@2|Bacteria,1GCIT@1117|Cyanobacteria,1HIT3@1161|Nostocales	1117|Cyanobacteria	E	D-isomer specific 2-hydroxyacid dehydrogenase	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
k59_516596_1	370438.PTH_1275	1.29e-103	325.0	COG1185@1|root,COG1185@2|Bacteria,1TQDW@1239|Firmicutes,248RW@186801|Clostridia,260DE@186807|Peptococcaceae	186801|Clostridia	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
k59_1683845_1	926569.ANT_11210	9.48e-56	190.0	COG3404@1|root,COG3643@1|root,COG3404@2|Bacteria,COG3643@2|Bacteria,2G64T@200795|Chloroflexi	200795|Chloroflexi	E	Formiminotransferase domain, N-terminal subdomain	-	-	2.1.2.5,4.3.1.4	ko:K00603,ko:K13990	ko00340,ko00670,ko01100,map00340,map00670,map01100	-	R02287,R02302,R03189	RC00165,RC00221,RC00223,RC00688,RC00870	ko00000,ko00001,ko01000,ko03036,ko04147	-	-	-	FTCD,FTCD_C,FTCD_N
k59_1572743_1	1121422.AUMW01000021_gene1633	2.5e-17	80.1	COG0370@1|root,COG0370@2|Bacteria,1V1U0@1239|Firmicutes,24GXR@186801|Clostridia,2651J@186807|Peptococcaceae	186801|Clostridia	P	Ferrous iron transport protein B	-	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_N
k59_1572743_2	926569.ANT_26920	2.62e-36	130.0	COG0735@1|root,COG0735@2|Bacteria	2|Bacteria	P	belongs to the Fur family	-	-	-	ko:K02076,ko:K03711,ko:K09825	-	-	-	-	ko00000,ko03000	-	-	-	FUR
k59_1183642_1	1392501.JIAC01000001_gene2144	3.99e-10	62.0	COG1028@1|root,COG1028@2|Bacteria,1TR53@1239|Firmicutes,4H8W6@909932|Negativicutes	909932|Negativicutes	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_1572745_1	316274.Haur_4594	9.27e-17	80.5	COG0104@1|root,COG0104@2|Bacteria,2G602@200795|Chloroflexi,374RV@32061|Chloroflexia	32061|Chloroflexia	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
k59_1017266_1	751944.HALDL1_10600	3.22e-16	84.7	COG0609@1|root,arCOG01007@2157|Archaea,2XT1A@28890|Euryarchaeota,23SGP@183963|Halobacteria	183963|Halobacteria	P	ABC-type Fe3 -siderophore transport system, permease component	btuC	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
k59_906286_1	640081.Dsui_0657	1.64e-63	223.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VJBX@28216|Betaproteobacteria,2KU9U@206389|Rhodocyclales	206389|Rhodocyclales	NT	Methyl-accepting chemotaxis protein	pilJ	-	-	ko:K02660	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	MCPsignal,PilJ
k59_516623_1	1173023.KE650771_gene5279	1.71e-68	228.0	COG1452@1|root,COG1452@2|Bacteria,1G0TW@1117|Cyanobacteria	1117|Cyanobacteria	M	PFAM Mannosyl oligosaccharide glucosidase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_63
k59_516623_2	118173.KB235914_gene2349	2.32e-11	62.4	COG0431@1|root,COG0431@2|Bacteria,1G3AZ@1117|Cyanobacteria,1HAU3@1150|Oscillatoriales	1117|Cyanobacteria	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
k59_1183680_1	316274.Haur_2471	7.36e-25	104.0	COG1840@1|root,COG1840@2|Bacteria,2G65V@200795|Chloroflexi,376WG@32061|Chloroflexia	32061|Chloroflexia	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02055	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	SBP_bac_6
k59_684068_2	1054213.HMPREF9946_03767	6.26e-67	213.0	COG1028@1|root,COG1028@2|Bacteria,1MWJI@1224|Proteobacteria,2TRNJ@28211|Alphaproteobacteria,2JSDH@204441|Rhodospirillales	204441|Rhodospirillales	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_1294532_1	1038859.AXAU01000002_gene255	4.59e-57	194.0	COG1680@1|root,COG1680@2|Bacteria,1MY4Y@1224|Proteobacteria,2TYCG@28211|Alphaproteobacteria,3JTS9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	V	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_1461903_1	1227488.C477_01540	6.97e-12	65.5	COG0277@1|root,arCOG00340@2157|Archaea,2Y85H@28890|Euryarchaeota,24157@183963|Halobacteria	183963|Halobacteria	C	COG0277 FAD FMN-containing dehydrogenases	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
k59_1683896_1	864051.BurJ1DRAFT_2687	6.85e-75	239.0	COG2391@1|root,COG2391@2|Bacteria,1RIWE@1224|Proteobacteria,2VWMP@28216|Betaproteobacteria,1KNZM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Sulphur transport	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
k59_16395_1	1304874.JAFY01000005_gene1243	7.53e-10	60.8	COG1475@1|root,COG1475@2|Bacteria,3TAV9@508458|Synergistetes	508458|Synergistetes	K	Belongs to the ParB family	-	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
k59_16395_2	59538.XP_005978949.1	9.55e-60	208.0	COG0445@1|root,COG0486@1|root,KOG1191@2759|Eukaryota,KOG2311@2759|Eukaryota,38BWB@33154|Opisthokonta,3BFG6@33208|Metazoa,3CTUH@33213|Bilateria,482PJ@7711|Chordata,48ZK1@7742|Vertebrata,3J993@40674|Mammalia,4IZ2Z@91561|Cetartiodactyla	33154|Opisthokonta	J	Protein MTO1 homolog	MTO1	GO:0000166,GO:0000959,GO:0000963,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0030488,GO:0032259,GO:0032543,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043414,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0070525,GO:0070899,GO:0070900,GO:0071704,GO:0090304,GO:0090646,GO:0097159,GO:0140053,GO:1900864,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K03495,ko:K12479	ko04138,ko04144,map04138,map04144	-	R08701	RC00053,RC00209,RC00870	ko00000,ko00001,ko03016,ko03036,ko04131	-	-	-	GIDA,GIDA_assoc
k59_126689_1	1172179.AUKV01000008_gene4619	2.08e-81	256.0	COG0667@1|root,COG0667@2|Bacteria,2GKEP@201174|Actinobacteria	201174|Actinobacteria	C	Aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_1739496_1	1122927.KB895420_gene4153	9.24e-22	100.0	COG4188@1|root,COG4188@2|Bacteria,1UZMD@1239|Firmicutes,4HEFX@91061|Bacilli,26SNS@186822|Paenibacillaceae	91061|Bacilli	S	dienelactone hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	PAF-AH_p_II
k59_1406181_1	1158756.AQXQ01000009_gene1006	3.47e-34	140.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,1SZ84@1236|Gammaproteobacteria,1WXUW@135613|Chromatiales	135613|Chromatiales	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_1461934_1	634497.HAH_2699	2.58e-05	47.8	COG0444@1|root,COG4608@1|root,arCOG00181@2157|Archaea,arCOG00184@2157|Archaea,2XSTM@28890|Euryarchaeota,240TG@183963|Halobacteria	183963|Halobacteria	E	COG1123 ATPase components of various ABC-type transport systems, contain duplicated ATPase	dppF	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_1461934_2	649747.HMPREF0083_02023	3.43e-35	129.0	COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,4H9YB@91061|Bacilli,26QEH@186822|Paenibacillaceae	91061|Bacilli	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
k59_461618_1	247490.KSU1_D0961	8.31e-18	86.3	COG2202@1|root,COG4191@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,2IZWU@203682|Planctomycetes	203682|Planctomycetes	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
k59_1350367_1	1144275.COCOR_00260	1.22e-63	225.0	COG0577@1|root,COG0577@2|Bacteria,1NREW@1224|Proteobacteria	1224|Proteobacteria	V	COG0577 ABC-type antimicrobial peptide transport system permease component	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_182607_1	1122927.KB895420_gene4072	3.75e-33	130.0	COG1070@1|root,COG1070@2|Bacteria,1W6WP@1239|Firmicutes,4IH6F@91061|Bacilli,26W8K@186822|Paenibacillaceae	91061|Bacilli	G	FGGY family of carbohydrate kinases, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	FGGY_C,FGGY_N
k59_16438_1	1048339.KB913029_gene4130	6.79e-50	167.0	COG3384@1|root,COG3384@2|Bacteria,2GKTV@201174|Actinobacteria,4ESG8@85013|Frankiales	201174|Actinobacteria	S	Extradiol ring-cleavage dioxygenase class III protein subunit B	-	-	-	ko:K15777	ko00965,map00965	-	R08836	RC00387	ko00000,ko00001,ko01000	-	-	-	LigB
k59_1739531_1	340099.Teth39_1788	2.37e-27	109.0	COG1040@1|root,COG1040@2|Bacteria,1VF2G@1239|Firmicutes,24IG6@186801|Clostridia,42FNR@68295|Thermoanaerobacterales	186801|Clostridia	F	PFAM Phosphoribosyltransferase	comF	-	-	ko:K02242	-	M00429	-	-	ko00000,ko00002,ko02044	-	-	-	Pribosyltran
k59_627212_2	926569.ANT_28850	2.13e-63	196.0	COG1765@1|root,COG1765@2|Bacteria	2|Bacteria	O	OsmC-like protein	ycaO	-	-	ko:K09136	-	-	-	-	ko00000,ko03009	-	-	-	OsmC,YcaO
k59_182609_1	1282876.BAOK01000001_gene1027	5.03e-61	193.0	COG0242@1|root,COG0242@2|Bacteria,1R9XK@1224|Proteobacteria,2U7NP@28211|Alphaproteobacteria,4BSH6@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	-	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
k59_1350376_1	1089550.ATTH01000001_gene2443	1.36e-66	214.0	COG0372@1|root,COG0372@2|Bacteria,4NFXK@976|Bacteroidetes,1FIQ8@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	C	Belongs to the citrate synthase family	prpC	-	2.3.3.1,2.3.3.5	ko:K01647,ko:K01659	ko00020,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351,R00931	RC00004,RC00067,RC00406,RC02827	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
k59_349276_1	880072.Desac_1035	1.73e-166	500.0	COG0067@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0070@2|Bacteria,1NZ4D@1224|Proteobacteria,43B3T@68525|delta/epsilon subdivisions,2X6HR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	GXGXG motif	-	-	-	-	-	-	-	-	-	-	-	-	GATase_6,GXGXG
k59_794830_1	338963.Pcar_1347	4.11e-45	159.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,42M98@68525|delta/epsilon subdivisions,2WMKB@28221|Deltaproteobacteria,43TPY@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	Integrase core domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,HTH_Tnp_1,rve
k59_571726_1	448385.sce1753	9.44e-36	125.0	COG1592@1|root,COG1592@2|Bacteria,1R9WG@1224|Proteobacteria,42N9V@68525|delta/epsilon subdivisions,2WJWQ@28221|Deltaproteobacteria,2YV2V@29|Myxococcales	28221|Deltaproteobacteria	C	Rubrerythrin	rbr	GO:0003674,GO:0005488,GO:0005506,GO:0043167,GO:0043169,GO:0046872,GO:0046914	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
k59_1128853_1	414684.RC1_2799	3.7e-57	187.0	COG1806@1|root,COG1806@2|Bacteria,1MUHU@1224|Proteobacteria,2TT66@28211|Alphaproteobacteria,2JPUF@204441|Rhodospirillales	204441|Rhodospirillales	S	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation	-	-	2.7.11.33,2.7.4.28	ko:K09773	-	-	-	-	ko00000,ko01000	-	-	-	Kinase-PPPase
k59_182627_1	391625.PPSIR1_22471	3.76e-26	109.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,42NYP@68525|delta/epsilon subdivisions,2WIPJ@28221|Deltaproteobacteria,2YXKT@29|Myxococcales	28221|Deltaproteobacteria	S	Insulinase (Peptidase family M16)	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_71681_1	391603.FBALC1_03107	2.14e-54	189.0	COG0206@1|root,COG0206@2|Bacteria,4NF8N@976|Bacteroidetes,1HWTE@117743|Flavobacteriia	976|Bacteroidetes	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
k59_1294615_1	1382306.JNIM01000001_gene3986	2.62e-10	62.4	COG0619@1|root,COG0619@2|Bacteria,2G8RH@200795|Chloroflexi	200795|Chloroflexi	P	Cobalt transport protein	-	-	-	ko:K16785	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	CbiQ
k59_1294615_2	290397.Adeh_3396	1.89e-93	291.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,42MHP@68525|delta/epsilon subdivisions,2WIQG@28221|Deltaproteobacteria,2YUFQ@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_1572895_1	1068980.ARVW01000001_gene3088	8.62e-44	154.0	COG1125@1|root,COG1125@2|Bacteria,2GJHI@201174|Actinobacteria,4DY7Y@85010|Pseudonocardiales	201174|Actinobacteria	E	glycine betaine	opuBA	-	-	ko:K05847	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	ABC_tran,CBS
k59_516739_2	1469245.JFBG01000014_gene2025	2.77e-57	187.0	COG3181@1|root,COG3181@2|Bacteria,1MXEX@1224|Proteobacteria,1S9CF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_405459_1	575589.HMPREF0018_01085	1.95e-67	221.0	COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,1RMU9@1236|Gammaproteobacteria,3NIEX@468|Moraxellaceae	1236|Gammaproteobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ffh	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006605,GO:0006612,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032991,GO:0033036,GO:0034613,GO:0035639,GO:0036094,GO:0042886,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045184,GO:0046907,GO:0048500,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0071702,GO:0071705,GO:0072657,GO:0090150,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1990904	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
k59_739351_1	1380391.JIAS01000014_gene1982	5.97e-27	108.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,2TRFK@28211|Alphaproteobacteria,2JVE1@204441|Rhodospirillales	204441|Rhodospirillales	C	Transketolase, pyrimidine binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Transket_pyr,Transketolase_C
k59_906422_1	509190.Cseg_1442	6.16e-40	144.0	COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,2TUHH@28211|Alphaproteobacteria,2KF0U@204458|Caulobacterales	204458|Caulobacterales	M	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis	lpxC	-	3.5.1.108	ko:K02535	ko00540,ko01100,map00540,map01100	M00060	R04587	RC00166,RC00300	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxC
k59_1739580_1	861299.J421_2604	3.33e-56	192.0	COG0318@1|root,COG0318@2|Bacteria,1ZSXP@142182|Gemmatimonadetes	142182|Gemmatimonadetes	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_739361_1	1347368.HG964403_gene4007	1.05e-17	84.7	COG4758@1|root,COG4758@2|Bacteria,1V9SU@1239|Firmicutes,4HJWC@91061|Bacilli,1ZGU8@1386|Bacillus	91061|Bacilli	S	N-terminal domain of toast_rack, DUF2154	-	-	-	-	-	-	-	-	-	-	-	-	DUF2154,Toast_rack_N
k59_16507_1	1116369.KB890026_gene5456	1.08e-46	163.0	COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,2TR5B@28211|Alphaproteobacteria,43IN4@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	amidohydrolase	MA20_09240	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
k59_1240822_1	1123070.KB899247_gene1442	2.33e-72	226.0	COG3637@1|root,COG3637@2|Bacteria	2|Bacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_71738_2	29581.BW37_00080	4.01e-88	266.0	COG0625@1|root,COG0625@2|Bacteria,1MXHH@1224|Proteobacteria,2VH95@28216|Betaproteobacteria,472S2@75682|Oxalobacteraceae	28216|Betaproteobacteria	O	Glutathione S-transferase, C-terminal domain	gstA	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_3,GST_N,GST_N_3
k59_182680_1	187303.BN69_2831	8.01e-28	114.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria,36X3A@31993|Methylocystaceae	28211|Alphaproteobacteria	P	E1-E2 ATPase	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
k59_182680_2	1125699.HMPREF9194_00701	3.63e-07	52.0	COG1937@1|root,COG1937@2|Bacteria,2J86Q@203691|Spirochaetes	203691|Spirochaetes	S	Metal-sensitive transcriptional repressor	-	-	-	ko:K21600	-	-	-	-	ko00000,ko03000	-	-	-	Trns_repr_metal
k59_349347_1	1379270.AUXF01000004_gene3298	7.7e-54	194.0	COG4206@1|root,COG4206@2|Bacteria,1ZUAE@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	TonB-dependent Receptor Plug Domain	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug
k59_1572941_1	292.DM42_963	6.35e-74	235.0	COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,2VHG9@28216|Betaproteobacteria,1JZN1@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Belongs to the ATCase OTCase family	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_1627912_1	1442599.JAAN01000011_gene341	2.3e-73	226.0	COG1704@1|root,COG1704@2|Bacteria,1MVH0@1224|Proteobacteria,1RP1N@1236|Gammaproteobacteria,1X4P0@135614|Xanthomonadales	135614|Xanthomonadales	S	LemA family	-	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
k59_480795_2	1499967.BAYZ01000196_gene3073	1.98e-52	177.0	COG2379@1|root,COG2379@2|Bacteria,2NNQP@2323|unclassified Bacteria	2|Bacteria	G	MOFRL family	ttuD	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
k59_590945_1	1122605.KB893625_gene1665	3.74e-19	91.3	COG5476@1|root,COG5476@2|Bacteria,4NKYT@976|Bacteroidetes,1IV0Z@117747|Sphingobacteriia	976|Bacteroidetes	S	MlrC C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	DUF1485,MlrC_C
k59_868757_1	926569.ANT_22970	6.86e-83	266.0	COG0531@1|root,COG0531@2|Bacteria,2G5ZF@200795|Chloroflexi	200795|Chloroflexi	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
k59_424703_1	1089552.KI911559_gene1087	1.82e-56	189.0	COG0624@1|root,COG0624@2|Bacteria,1MVUX@1224|Proteobacteria,2TR5X@28211|Alphaproteobacteria,2JPJY@204441|Rhodospirillales	204441|Rhodospirillales	E	Peptidase family M20/M25/M40	-	-	3.5.1.6,3.5.1.87	ko:K06016	ko00240,ko01100,map00240,map01100	M00046	R00905,R04666	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
k59_1592840_1	1530186.JQEY01000012_gene2585	6.84e-82	247.0	COG0437@1|root,COG0437@2|Bacteria,1MU5T@1224|Proteobacteria,2VEY7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG0437 Fe-S-cluster-containing hydrogenase components 1	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_11,Fer4_3,Fer4_7
k59_314727_1	459495.SPLC1_S050830	4.23e-55	182.0	COG4974@1|root,COG4974@2|Bacteria,1G224@1117|Cyanobacteria,1H8SW@1150|Oscillatoriales	1117|Cyanobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
k59_1148581_1	313606.M23134_00340	5.01e-06	55.1	COG1262@1|root,COG1262@2|Bacteria,4NF01@976|Bacteroidetes,47JJI@768503|Cytophagia	976|Bacteroidetes	S	Sulfatase-modifying factor enzyme 1	egtB	-	-	-	-	-	-	-	-	-	-	-	DinB_2,FGE-sulfatase
k59_1645982_1	522306.CAP2UW1_4361	2.39e-70	221.0	COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,2VHNK@28216|Betaproteobacteria,1KQB2@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	D	4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family	parA	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
k59_758270_1	1237149.C900_00284	2.25e-07	57.4	COG0589@1|root,COG0589@2|Bacteria,4NFZ5@976|Bacteroidetes,47PIA@768503|Cytophagia	976|Bacteroidetes	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_645601_2	1279038.KB907343_gene2347	1.06e-74	238.0	COG1322@1|root,COG1322@2|Bacteria,1MWHV@1224|Proteobacteria,2TTX6@28211|Alphaproteobacteria,2JPI9@204441|Rhodospirillales	204441|Rhodospirillales	S	RmuC family	rmuC	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
k59_201105_1	1111728.ATYS01000016_gene4632	1.45e-05	45.1	2DT0U@1|root,33I6V@2|Bacteria,1NMHR@1224|Proteobacteria,1SGK7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_145976_1	1281779.H009_19569	1.93e-26	111.0	COG0477@1|root,COG2814@2|Bacteria,1QTX0@1224|Proteobacteria,2TUM5@28211|Alphaproteobacteria,4B84R@82115|Rhizobiaceae	28211|Alphaproteobacteria	EGP	Major facilitator superfamily	-	-	-	ko:K08225	-	-	-	-	ko00000,ko02000	2.A.1.38	-	-	MFS_1,MFS_3
k59_1148609_1	379066.GAU_2419	1.79e-28	115.0	COG0859@1|root,COG0859@2|Bacteria,1ZT3G@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	ko:K12982	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
k59_91067_1	765420.OSCT_2320	7.27e-40	154.0	COG0664@1|root,COG1994@1|root,COG2905@1|root,COG0664@2|Bacteria,COG1994@2|Bacteria,COG2905@2|Bacteria,2GBJH@200795|Chloroflexi,3761G@32061|Chloroflexia	32061|Chloroflexia	T	PFAM cyclic nucleotide-binding	-	-	-	ko:K16922	-	-	-	-	ko00000,ko01002	-	-	-	cNMP_binding
k59_868846_1	1313172.YM304_26890	2.24e-74	242.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,2GKXV@201174|Actinobacteria	201174|Actinobacteria	C	Ferredoxin oxidoreductase	porA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
k59_1592906_1	1177179.A11A3_07193	4.08e-43	151.0	COG1055@1|root,COG1055@2|Bacteria,1MUH8@1224|Proteobacteria,1RPSM@1236|Gammaproteobacteria,1XIRZ@135619|Oceanospirillales	135619|Oceanospirillales	P	Na H antiporter NhaD and related arsenite	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
k59_1757589_1	926550.CLDAP_13320	1.24e-43	155.0	COG1609@1|root,COG1609@2|Bacteria,2G7SU@200795|Chloroflexi	200795|Chloroflexi	K	helix_turn _helix lactose operon repressor	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
k59_868863_1	479434.Sthe_2949	1.13e-20	92.8	COG0247@1|root,COG1139@1|root,COG0247@2|Bacteria,COG1139@2|Bacteria,2G665@200795|Chloroflexi,27XZR@189775|Thermomicrobia	189775|Thermomicrobia	C	LUD domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8,LUD_dom
k59_868863_2	35754.JNYJ01000014_gene4853	1.1e-30	119.0	COG0500@1|root,COG0500@2|Bacteria,2I43G@201174|Actinobacteria,4DJ41@85008|Micromonosporales	201174|Actinobacteria	Q	Methyltransferase domain	-	-	2.1.1.235	ko:K13307	ko00523,ko01130,map00523,map01130	M00796	R06439	RC00003,RC01515	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_25
k59_1038865_1	751945.Theos_0291	2.58e-42	143.0	COG0096@1|root,COG0096@2|Bacteria,1WK0N@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
k59_1705450_1	861299.J421_6291	3.31e-93	286.0	COG0004@1|root,COG0004@2|Bacteria,1ZT74@142182|Gemmatimonadetes	142182|Gemmatimonadetes	U	Ammonium Transporter Family	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_814020_1	197221.22296018	4.5e-27	112.0	COG5505@1|root,COG5505@2|Bacteria,1G9X6@1117|Cyanobacteria	1117|Cyanobacteria	S	Protein of unknown function (DUF819)	-	-	-	-	-	-	-	-	-	-	-	-	DUF819
k59_1148646_2	1037409.BJ6T_61780	7.26e-39	147.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2TRWM@28211|Alphaproteobacteria,3JVS5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_536111_2	861299.J421_3281	3.5e-49	171.0	COG1109@1|root,COG1109@2|Bacteria,1ZSP6@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Phosphoglucomutase/phosphomannomutase, C-terminal domain	-	-	5.4.2.2,5.4.2.8	ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_703853_1	1121013.P873_05855	2.16e-40	153.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1X465@135614|Xanthomonadales	135614|Xanthomonadales	E	Glutamate synthase	gltB	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_536127_2	575589.HMPREF0018_01165	3.82e-06	51.6	COG0589@1|root,COG0589@2|Bacteria,1MZ3K@1224|Proteobacteria,1SF1R@1236|Gammaproteobacteria,3NP0V@468|Moraxellaceae	1236|Gammaproteobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_1536359_1	472759.Nhal_0669	1.93e-83	261.0	COG2719@1|root,COG2719@2|Bacteria,1MW6U@1224|Proteobacteria,1RPU2@1236|Gammaproteobacteria,1WWU8@135613|Chromatiales	135613|Chromatiales	S	SpoVR family	-	-	-	ko:K06415	-	-	-	-	ko00000	-	-	-	SpoVR
k59_1757650_1	983545.Glaag_2961	5.75e-28	103.0	COG0346@1|root,COG0346@2|Bacteria,1RH8Z@1224|Proteobacteria,1SAVZ@1236|Gammaproteobacteria,467S8@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
k59_369040_1	258594.RPA2625	9.24e-97	297.0	COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,2U0MX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Cys/Met metabolism PLP-dependent enzyme	-	-	2.5.1.48,4.4.1.11	ko:K01739,ko:K01761	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00654,R00999,R01288,R02508,R03217,R03260,R04770,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00196,RC00348,RC00420,RC01209,RC01210,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
k59_482832_1	631454.N177_1384	1.93e-37	134.0	COG4395@1|root,COG4395@2|Bacteria,1NCIX@1224|Proteobacteria,2TTDQ@28211|Alphaproteobacteria,1JNVN@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Tim44	MA20_24770	-	-	-	-	-	-	-	-	-	-	-	Tim44
k59_482832_2	266779.Meso_3484	2.28e-14	70.5	COG3030@1|root,COG3030@2|Bacteria,1MZJJ@1224|Proteobacteria,2UF72@28211|Alphaproteobacteria,43KI0@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	COG3030 Protein affecting phage T7 exclusion by the F plasmid	fxsA	-	-	ko:K07113	-	-	-	-	ko00000	-	-	-	FxsA
k59_1038934_1	2340.JV46_05690	6.78e-110	327.0	COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,1RN7B@1236|Gammaproteobacteria,1JBRQ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	L COG2826 Transposase and inactivated derivatives, IS30 family	insI	GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004803,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006310,GO:0006313,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0030983,GO:0032135,GO:0032196,GO:0032991,GO:0032993,GO:0034641,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363	-	ko:K07482	-	-	-	-	ko00000	-	-	-	HTH_38,rve
k59_868955_1	1347086.CCBA010000003_gene3873	2.1e-09	61.2	COG2055@1|root,COG2055@2|Bacteria,1TR0Z@1239|Firmicutes,4HB6X@91061|Bacilli,1ZB9H@1386|Bacillus	91061|Bacilli	C	Belongs to the LDH2 MDH2 oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Ldh_2
k59_982634_1	926569.ANT_13370	5.54e-120	356.0	COG0464@1|root,COG0464@2|Bacteria,2G642@200795|Chloroflexi	200795|Chloroflexi	O	SMART AAA ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AAA
k59_1482016_1	321332.CYB_1358	7.46e-16	76.6	COG0686@1|root,COG0686@2|Bacteria,1G11E@1117|Cyanobacteria,1GYTX@1129|Synechococcus	1117|Cyanobacteria	C	Belongs to the AlaDH PNT family	ald	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
k59_1482016_2	880073.Calab_0510	5.94e-39	141.0	COG4992@1|root,COG4992@2|Bacteria,2NS3R@2323|unclassified Bacteria	2|Bacteria	E	Aminotransferase class-III	rocD	GO:0003674,GO:0003824,GO:0004587,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016740,GO:0016769,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	2.6.1.11,2.6.1.13,2.6.1.17	ko:K00819,ko:K00821	ko00220,ko00300,ko00330,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map00330,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R00667,R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iYO844.BSU40340	Aminotran_3
k59_1148704_1	1232683.ADIMK_3763	1.33e-06	55.8	COG1361@1|root,COG1361@2|Bacteria,1R2T2@1224|Proteobacteria,1T5WX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Conserved repeat domain	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1425599_1	1283299.AUKG01000001_gene1412	3.86e-77	252.0	COG3119@1|root,COG3119@2|Bacteria,2GJ8H@201174|Actinobacteria	201174|Actinobacteria	P	Pfam Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_1148712_1	929713.NIASO_09575	1.23e-61	205.0	COG0612@1|root,COG0612@2|Bacteria,4NEPT@976|Bacteroidetes,1IQD7@117747|Sphingobacteriia	976|Bacteroidetes	S	Peptidase M16 inactive domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_424860_1	309807.SRU_2749	4.76e-80	266.0	COG5549@1|root,COG5549@2|Bacteria,4NEA0@976|Bacteroidetes,1FK0K@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	O	Domain of unknown function (DUF5118)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4953,DUF5117,DUF5118
k59_1536397_1	926569.ANT_25430	4.76e-59	204.0	COG2335@1|root,COG2335@2|Bacteria,2G7AJ@200795|Chloroflexi	200795|Chloroflexi	M	Four repeated domains in the Fasciclin I family of proteins, present in many other contexts.	-	-	-	-	-	-	-	-	-	-	-	-	Fasciclin
k59_1148727_1	671143.DAMO_2077	7.43e-83	252.0	COG0020@1|root,COG0020@2|Bacteria,2NP9M@2323|unclassified Bacteria	2|Bacteria	I	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617	2.5.1.31,2.5.1.68	ko:K00806,ko:K12503	ko00900,ko01110,map00900,map01110	-	R06447,R08528	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
k59_869028_1	926569.ANT_25450	4.02e-101	301.0	COG2896@1|root,COG2896@2|Bacteria,2G5JT@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Mob_synth_C,Radical_SAM
k59_91186_1	526222.Desal_3197	2.19e-63	204.0	COG1148@1|root,COG1148@2|Bacteria,1R0SK@1224|Proteobacteria,43EFN@68525|delta/epsilon subdivisions,2X89E@28221|Deltaproteobacteria,2MHDW@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
k59_1260947_2	1089546.AQUI01000002_gene3123	4.86e-13	72.4	COG3135@1|root,COG3135@2|Bacteria,2GNQX@201174|Actinobacteria	201174|Actinobacteria	Q	benzoate membrane transport protein	benE	-	-	ko:K05782	-	-	-	-	ko00000,ko02000	2.A.46.1	-	-	BenE
k59_814120_1	335543.Sfum_3271	3.86e-66	222.0	COG1061@1|root,COG4951@1|root,COG1061@2|Bacteria,COG4951@2|Bacteria,1Q4TM@1224|Proteobacteria,43A26@68525|delta/epsilon subdivisions,2X24Y@28221|Deltaproteobacteria,2MSDH@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	Type III restriction enzyme res subunit	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1370763_1	1206720.BAFQ01000130_gene3232	1.35e-13	67.8	COG2350@1|root,COG2350@2|Bacteria,2GQTW@201174|Actinobacteria,4G36T@85025|Nocardiaceae	201174|Actinobacteria	S	YCII-related domain	-	-	-	ko:K09780	-	-	-	-	ko00000	-	-	-	YCII
k59_1370763_2	266117.Rxyl_0695	2.68e-22	94.0	COG0483@1|root,COG0483@2|Bacteria,2GKZZ@201174|Actinobacteria	201174|Actinobacteria	G	inositol monophosphatase	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
k59_703945_1	326427.Cagg_1658	2.25e-91	282.0	COG2986@1|root,COG2986@2|Bacteria,2G66R@200795|Chloroflexi,3772R@32061|Chloroflexia	32061|Chloroflexia	E	PFAM phenylalanine histidine ammonia-lyase	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
k59_645727_1	1056820.KB900699_gene1300	5.91e-61	207.0	COG1409@1|root,COG1409@2|Bacteria,1N44U@1224|Proteobacteria,1RY17@1236|Gammaproteobacteria,2PPPB@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	S	SdrD B-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,MetallophosC,MetallophosN
k59_1482090_1	926569.ANT_04320	2.99e-90	272.0	COG0491@1|root,COG0491@2|Bacteria,2G8XN@200795|Chloroflexi	200795|Chloroflexi	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_1593104_1	426114.THI_2183	1.01e-67	220.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,2VHNG@28216|Betaproteobacteria,1KJNP@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
k59_1593104_2	987059.RBXJA2T_14696	3.38e-15	74.7	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,2VH9X@28216|Betaproteobacteria,1KIYR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH,NMO
k59_928053_2	1196324.A374_16543	0.000274	43.9	COG0657@1|root,COG0657@2|Bacteria,1TQHX@1239|Firmicutes,4HB91@91061|Bacilli	91061|Bacilli	I	Esterase	-	-	-	ko:K01066	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_3
k59_369150_1	742817.HMPREF9449_02474	1.41e-90	276.0	COG0205@1|root,COG0205@2|Bacteria,4NFPT@976|Bacteroidetes,2FMJ9@200643|Bacteroidia,22ZT1@171551|Porphyromonadaceae	976|Bacteroidetes	G	Phosphofructokinase	-	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
k59_257360_2	402777.KB235903_gene1520	3.1e-23	102.0	COG0477@1|root,COG2814@2|Bacteria,1GQ8C@1117|Cyanobacteria,1HH9P@1150|Oscillatoriales	1117|Cyanobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_591173_1	1120936.KB907209_gene1690	7.37e-15	79.0	COG0365@1|root,COG0365@2|Bacteria,2GJVK@201174|Actinobacteria,4EH74@85012|Streptosporangiales	201174|Actinobacteria	I	AMP-binding enzyme C-terminal domain	-	-	6.2.1.50	ko:K12424	-	-	R11608,R11872,R11873	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_869074_1	519989.ECTPHS_04304	0.000182	44.7	COG3156@1|root,COG3156@2|Bacteria,1RAQM@1224|Proteobacteria,1S2N8@1236|Gammaproteobacteria,1WZTA@135613|Chromatiales	135613|Chromatiales	U	General secretion pathway protein K	-	-	-	ko:K02460	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSK
k59_869074_2	1333856.L686_19370	4.01e-15	76.3	COG4795@1|root,COG4795@2|Bacteria,1RJAE@1224|Proteobacteria,1S5ZZ@1236|Gammaproteobacteria,1Z19U@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	U	General secretion pathway protein J	gspJ	GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0098776	-	ko:K02459	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSJ
k59_1148782_1	381666.H16_A1706	1.61e-57	199.0	COG1404@1|root,COG1404@2|Bacteria,1REVZ@1224|Proteobacteria,2WDV2@28216|Betaproteobacteria,1KB1U@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Subtilase family	-	-	-	ko:K17734	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S8
k59_146165_2	1121877.JQKF01000006_gene914	9.33e-15	75.5	COG0542@1|root,COG0542@2|Bacteria,2GJ73@201174|Actinobacteria,4CMTX@84992|Acidimicrobiia	84992|Acidimicrobiia	O	C-terminal, D2-small domain, of ClpB protein	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_869104_1	102129.Lepto7375DRAFT_2447	2.91e-05	45.4	COG0106@1|root,COG0106@2|Bacteria,1G1S9@1117|Cyanobacteria,1H7RU@1150|Oscillatoriales	1117|Cyanobacteria	E	1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase	hisA	GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
k59_869104_2	85643.Tmz1t_0907	6.32e-77	235.0	COG0118@1|root,COG0118@2|Bacteria,1MU4X@1224|Proteobacteria,2VJPI@28216|Betaproteobacteria,2KUCS@206389|Rhodocyclales	206389|Rhodocyclales	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
k59_424961_1	452637.Oter_0123	1.44e-36	142.0	COG4122@1|root,COG4122@2|Bacteria	2|Bacteria	E	O-methyltransferase activity	safC	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Methyltransf_24,Methyltransf_3
k59_928125_1	744980.TRICHSKD4_4392	6.63e-76	238.0	COG3768@1|root,COG3768@2|Bacteria,1MU8S@1224|Proteobacteria,2TU53@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	membrane	MA20_04555	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K08990	-	-	-	-	ko00000	-	-	-	DUF697
k59_591218_1	1123261.AXDW01000010_gene333	3.03e-54	181.0	2CIBN@1|root,2Z8JT@2|Bacteria,1R902@1224|Proteobacteria,1RXPM@1236|Gammaproteobacteria,1X5H4@135614|Xanthomonadales	135614|Xanthomonadales	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_424970_1	1048983.EL17_17955	2.91e-22	94.7	COG2220@1|root,COG2220@2|Bacteria,4NGD5@976|Bacteroidetes,47KU7@768503|Cytophagia	976|Bacteroidetes	S	Belongs to the UPF0173 family	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2,Lactamase_B_3
k59_424970_2	1396858.Q666_13575	3.03e-15	70.9	COG0509@1|root,COG0509@2|Bacteria,1RGV7@1224|Proteobacteria,1S656@1236|Gammaproteobacteria,46758@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
k59_606027_2	1449049.JONW01000012_gene276	1.88e-28	105.0	COG3549@1|root,COG3549@2|Bacteria,1MZKX@1224|Proteobacteria,2UBQF@28211|Alphaproteobacteria,2KJBX@204458|Caulobacterales	204458|Caulobacterales	S	RelE-like toxin of type II toxin-antitoxin system HigB	-	-	-	ko:K07334	-	-	-	-	ko00000,ko02048	-	-	-	HigB-like_toxin
k59_107416_1	391600.ABRU01000022_gene799	3.06e-16	82.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQPG@28211|Alphaproteobacteria,2KFDD@204458|Caulobacterales	204458|Caulobacterales	T	two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_107416_2	388413.ALPR1_02225	9.36e-10	61.2	COG3292@1|root,COG4191@1|root,COG3292@2|Bacteria,COG4191@2|Bacteria,4NEJX@976|Bacteroidetes,47N98@768503|Cytophagia	976|Bacteroidetes	T	Y_Y_Y domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Reg_prop,Y_Y_Y
k59_1388728_1	1380391.JIAS01000011_gene4773	8.06e-39	149.0	COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,2TS4D@28211|Alphaproteobacteria,2JPKU@204441|Rhodospirillales	204441|Rhodospirillales	S	Penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
k59_1218777_1	314282.PCNPT3_04535	9.51e-54	184.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,1RR2W@1236|Gammaproteobacteria,2QICJ@267894|Psychromonadaceae	1236|Gammaproteobacteria	L	COG3666 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_1662876_2	443255.SCLAV_0033	1.61e-13	71.6	COG3629@1|root,COG3629@2|Bacteria,2IC17@201174|Actinobacteria	201174|Actinobacteria	T	DNA-binding transcriptional activator of the SARP family	-	-	-	-	-	-	-	-	-	-	-	-	BTAD
k59_606045_2	379066.GAU_0638	2.69e-32	124.0	COG0745@1|root,COG0745@2|Bacteria,1ZTEW@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KT	PglZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PglZ,Response_reg
k59_830774_1	1430440.MGMSRv2_4248	4.69e-41	154.0	COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,2TSXA@28211|Alphaproteobacteria,2JPG2@204441|Rhodospirillales	204441|Rhodospirillales	OU	COG0616 Periplasmic serine proteases (ClpP class)	sppA	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
k59_1775493_1	95619.PM1_0204910	1.55e-59	191.0	COG0321@1|root,COG0321@2|Bacteria,1MU6A@1224|Proteobacteria,1RMXQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016053,GO:0016415,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0016874,GO:0016879,GO:0016979,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019222,GO:0019538,GO:0019752,GO:0032787,GO:0033819,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048519,GO:0050789,GO:0051186,GO:0051188,GO:0051604,GO:0060255,GO:0065007,GO:0071704,GO:0072330,GO:0140096,GO:1901360,GO:1901362,GO:1901564,GO:1901576	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	iECSF_1327.ECSF_0569,iSFV_1184.SFV_0696,iSFxv_1172.SFxv_0718	BPL_LplA_LipB
k59_1775493_2	1120977.JHUX01000003_gene726	1.44e-32	122.0	COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,1RMAT@1236|Gammaproteobacteria,3NJZS@468|Moraxellaceae	1236|Gammaproteobacteria	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	iAPECO1_1312.APECO1_1427,iB21_1397.B21_00586,iBWG_1329.BWG_0499,iE2348C_1286.E2348C_0528,iEC55989_1330.EC55989_0620,iECABU_c1320.ECABU_c06820,iECBD_1354.ECBD_3023,iECB_1328.ECB_00597,iECDH10B_1368.ECDH10B_0589,iECDH1ME8569_1439.ECDH1ME8569_0597,iECD_1391.ECD_00597,iECED1_1282.ECED1_0624,iECH74115_1262.ECH74115_0716,iECIAI1_1343.ECIAI1_0611,iECIAI39_1322.ECIAI39_0603,iECNA114_1301.ECNA114_0567,iECO103_1326.ECO103_0635,iECO111_1330.ECO111_0658,iECO26_1355.ECO26_0702,iECOK1_1307.ECOK1_0638,iECP_1309.ECP_0658,iECS88_1305.ECS88_0669,iECSE_1348.ECSE_0695,iECSF_1327.ECSF_0567,iECSP_1301.ECSP_0681,iECUMN_1333.ECUMN_0720,iECW_1372.ECW_m0682,iECs_1301.ECs0666,iEKO11_1354.EKO11_3238,iETEC_1333.ETEC_0656,iEcDH1_1363.EcDH1_2998,iEcE24377_1341.EcE24377A_0652,iEcHS_1320.EcHS_A0679,iEcSMS35_1347.EcSMS35_0648,iEcolC_1368.EcolC_3017,iG2583_1286.G2583_0791,iJO1366.b0628,iLF82_1304.LF82_1199,iNRG857_1313.NRG857_02855,iSBO_1134.SBO_0492,iSDY_1059.SDY_0550,iSF_1195.SF0653,iSFxv_1172.SFxv_0720,iSSON_1240.SSON_0582,iS_1188.S0675,iSbBS512_1146.SbBS512_E0542,iUMN146_1321.UM146_14375,iUMNK88_1353.UMNK88_663,iUTI89_1310.UTI89_C0631,iWFL_1372.ECW_m0682,iY75_1357.Y75_RS03275,ic_1306.c0718	LIAS_N,Radical_SAM
k59_1775496_1	457570.Nther_0312	1.09e-05	48.1	COG2362@1|root,COG2362@2|Bacteria,1TSUZ@1239|Firmicutes,24CY1@186801|Clostridia	186801|Clostridia	E	D-aminopeptidase	-	-	-	ko:K16203	-	-	-	-	ko00000,ko01000,ko01002	3.A.1.5.2	-	-	Peptidase_M55
k59_1775496_2	555779.Dthio_PD3478	2.28e-19	87.4	COG2006@1|root,COG2006@2|Bacteria,1NV7D@1224|Proteobacteria,42ZEV@68525|delta/epsilon subdivisions,2WV1N@28221|Deltaproteobacteria,2M8BU@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
k59_722225_1	671143.DAMO_2213	1.09e-102	314.0	COG1078@1|root,COG1078@2|Bacteria,2NPZN@2323|unclassified Bacteria	2|Bacteria	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06885	-	-	-	-	ko00000	-	-	-	HD
k59_661457_1	1254432.SCE1572_02795	8.7e-76	245.0	COG0515@1|root,COG0515@2|Bacteria,1P913@1224|Proteobacteria,4377Q@68525|delta/epsilon subdivisions,2X28Z@28221|Deltaproteobacteria,2YUDY@29|Myxococcales	28221|Deltaproteobacteria	KLT	Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
k59_1166913_1	1121091.AUMP01000005_gene1657	7.66e-93	284.0	COG0112@1|root,COG0112@2|Bacteria,1TQVM@1239|Firmicutes,4HA5K@91061|Bacilli	91061|Bacilli	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
k59_1609302_1	1283300.ATXB01000001_gene1628	4.14e-85	265.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,1RN8W@1236|Gammaproteobacteria,1XDX5@135618|Methylococcales	135618|Methylococcales	BQ	PFAM Histone deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
k59_661472_1	1122951.ATUE01000006_gene1387	1.06e-88	272.0	COG0332@1|root,COG0332@2|Bacteria,1PG6N@1224|Proteobacteria,1T9VU@1236|Gammaproteobacteria,3NQUF@468|Moraxellaceae	1236|Gammaproteobacteria	I	3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal	-	-	-	-	-	-	-	-	-	-	-	-	ACP_syn_III,ACP_syn_III_C
k59_1720401_1	861299.J421_3445	4.01e-96	290.0	COG0016@1|root,COG0016@2|Bacteria,1ZSQR@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Aminoacyl tRNA synthetase class II, N-terminal domain	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
k59_830830_1	755178.Cyan10605_1006	3.8e-64	198.0	COG0229@1|root,COG0229@2|Bacteria,1G5S6@1117|Cyanobacteria	1117|Cyanobacteria	O	Belongs to the MsrB Met sulfoxide reductase family	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
k59_1109585_1	1121033.AUCF01000001_gene2199	1.07e-55	184.0	COG2021@1|root,COG2021@2|Bacteria,1MVJV@1224|Proteobacteria,2TQYA@28211|Alphaproteobacteria,2JQPA@204441|Rhodospirillales	204441|Rhodospirillales	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	metXA	-	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
k59_51442_1	1229780.BN381_150112	7.97e-53	180.0	COG1283@1|root,COG1283@2|Bacteria,2IAMX@201174|Actinobacteria	201174|Actinobacteria	P	Na+/Pi-cotransporter	nptA	-	-	ko:K03324,ko:K14683	-	-	-	-	ko00000,ko02000,ko04147	2.A.58.1,2.A.58.2	-	-	Na_Pi_cotrans
k59_386272_1	243159.AFE_0934	9.25e-112	346.0	COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,1RMWZ@1236|Gammaproteobacteria,2NCER@225057|Acidithiobacillales	225057|Acidithiobacillales	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
k59_830859_2	1120956.JHZK01000010_gene2778	7.55e-18	83.2	COG5598@1|root,COG5598@2|Bacteria,1MWJN@1224|Proteobacteria,2TR0V@28211|Alphaproteobacteria,1JNQ6@119043|Rhodobiaceae	28211|Alphaproteobacteria	H	Trimethylamine methyltransferase (MTTB)	-	-	-	-	-	-	-	-	-	-	-	-	MTTB
k59_1500320_1	754035.Mesau_01519	0.00017	48.9	COG3181@1|root,COG3181@2|Bacteria,1N3HN@1224|Proteobacteria,2UDSB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_107489_1	1146883.BLASA_3316	6.34e-44	153.0	COG0500@1|root,COG2226@2|Bacteria,2HEKM@201174|Actinobacteria	201174|Actinobacteria	Q	Methyltransferase type 11	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
k59_1720425_1	1521187.JPIM01000094_gene1034	8.26e-28	104.0	COG0377@1|root,COG0377@2|Bacteria,2G6GB@200795|Chloroflexi,375GU@32061|Chloroflexia	32061|Chloroflexia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB1	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
k59_1720425_2	926569.ANT_08290	1.91e-41	139.0	COG0838@1|root,COG0838@2|Bacteria,2G78Y@200795|Chloroflexi	200795|Chloroflexi	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoA	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
k59_1109608_2	1123401.JHYQ01000007_gene542	3.47e-69	233.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,1RN6N@1236|Gammaproteobacteria,461JN@72273|Thiotrichales	72273|Thiotrichales	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_386280_1	1279017.AQYJ01000025_gene582	1.12e-19	86.7	COG2025@1|root,COG2025@2|Bacteria,1MUFI@1224|Proteobacteria,1RMK7@1236|Gammaproteobacteria,465NP@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	electron transfer flavoprotein, alpha subunit	etfA	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
k59_386280_2	1279017.AQYJ01000025_gene583	8.73e-71	219.0	COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,1RN6F@1236|Gammaproteobacteria,464UJ@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	Electron transfer flavoprotein	etfB	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
k59_441689_1	1122134.KB893650_gene893	5.22e-107	328.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,1RQ7D@1236|Gammaproteobacteria,1XJG7@135619|Oceanospirillales	135619|Oceanospirillales	E	Asparagine synthase	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
k59_887795_1	765910.MARPU_00500	8.34e-67	218.0	COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,1RPUZ@1236|Gammaproteobacteria,1WXUS@135613|Chromatiales	135613|Chromatiales	E	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
k59_441705_1	926569.ANT_02410	3.08e-77	244.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	pelF	-	-	ko:K21011,ko:K21012	ko02025,map02025	-	-	-	ko00000,ko00001,ko01003	-	GT4	-	DUF3492,Glyco_trans_1_4,Glycos_transf_1
k59_441705_2	121759.XP_010756353.1	5.55e-22	95.9	COG0520@1|root,KOG2142@2759|Eukaryota,38F30@33154|Opisthokonta,3NY5Z@4751|Fungi,3QREF@4890|Ascomycota,20FDX@147545|Eurotiomycetes,3B2AK@33183|Onygenales,3FQBE@34383|Onygenales incertae sedis	4751|Fungi	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
k59_606132_1	935548.KI912159_gene6126	3.01e-18	82.0	COG4454@1|root,COG4454@2|Bacteria,1N1PE@1224|Proteobacteria,2UCWF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	SoxE
k59_215899_2	1038859.AXAU01000034_gene170	2.68e-33	121.0	COG0250@1|root,COG0250@2|Bacteria,1N01W@1224|Proteobacteria,2U697@28211|Alphaproteobacteria,3JY91@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	In Spt5p, this domain may confer affinity for Spt4p. It possesses a RNP-like fold.	-	-	-	ko:K05785	-	-	-	-	ko00000,ko03000	-	-	-	NusG
k59_1055407_1	1122138.AQUZ01000022_gene8740	5.77e-06	49.7	COG0697@1|root,COG0697@2|Bacteria,2GNSA@201174|Actinobacteria,4DQG4@85009|Propionibacteriales	201174|Actinobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_1055407_2	715226.ABI_44280	8.5e-12	67.8	COG0627@1|root,COG0627@2|Bacteria,1QIRQ@1224|Proteobacteria,2U23Q@28211|Alphaproteobacteria,2KHJT@204458|Caulobacterales	204458|Caulobacterales	S	esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
k59_1720452_1	98439.AJLL01000077_gene3089	8.9e-64	207.0	COG1690@1|root,COG1690@2|Bacteria,1G0YE@1117|Cyanobacteria	1117|Cyanobacteria	L	family UPF0027	rtcB	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
k59_1775633_1	1242864.D187_005720	1.12e-24	98.6	COG1434@1|root,COG1434@2|Bacteria,1RJU2@1224|Proteobacteria	1224|Proteobacteria	S	DUF218 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
k59_1775637_2	1122135.KB893137_gene1196	3.29e-32	124.0	COG1653@1|root,COG1653@2|Bacteria,1MVMW@1224|Proteobacteria,2TTMX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	ABC-type sugar transport system periplasmic component	-	-	-	ko:K02027,ko:K05813	ko02010,map02010	M00198,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.3	-	-	SBP_bac_8
k59_1442559_1	443143.GM18_0464	3.71e-77	242.0	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,42NC3@68525|delta/epsilon subdivisions,2WIJJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	PFAM ABC-2 type transporter	ybhR	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
k59_1055423_1	1313172.YM304_38220	8.98e-61	201.0	COG1921@1|root,COG1921@2|Bacteria,2HFGK@201174|Actinobacteria	201174|Actinobacteria	E	Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis	selA	-	2.9.1.1	ko:K01042	ko00450,ko00970,map00450,map00970	-	R08219	RC01246	ko00000,ko00001,ko01000	-	-	-	Se-cys_synth_N,SelA
k59_51514_1	1235457.C404_06790	1.53e-27	103.0	COG2963@1|root,COG2963@2|Bacteria,1RIC2@1224|Proteobacteria,2VTGY@28216|Betaproteobacteria,1K9Z5@119060|Burkholderiaceae	28216|Betaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_606155_3	931627.MycrhDRAFT_2278	7.19e-11	62.0	COG0492@1|root,COG0492@2|Bacteria,2GKD2@201174|Actinobacteria,234E1@1762|Mycobacteriaceae	201174|Actinobacteria	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	GO:0000166,GO:0001666,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019725,GO:0036094,GO:0036293,GO:0040007,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070402,GO:0070482,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748	1.8.1.9	ko:K00384,ko:K03671	ko00450,ko04621,ko05418,map00450,map04621,map05418	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000,ko03110	-	-	iNJ661.Rv3913	Pyr_redox_2
k59_773614_1	368408.Tpen_1144	4.02e-05	46.6	COG0467@1|root,arCOG01171@2157|Archaea,2XPS8@28889|Crenarchaeota	28889|Crenarchaeota	T	Circadian clock protein KaiC	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
k59_1551129_1	1463821.JOGR01000013_gene3255	2.66e-33	130.0	COG0488@1|root,COG0488@2|Bacteria,2GKQ4@201174|Actinobacteria,4EY15@85014|Glycomycetales	201174|Actinobacteria	S	ABC transporter	ybiT	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_Xtn,DLIC
k59_1775659_1	635013.TherJR_1205	8.5e-48	176.0	COG0514@1|root,COG0608@1|root,COG0514@2|Bacteria,COG0608@2|Bacteria,1TPXE@1239|Firmicutes,247NU@186801|Clostridia,25ZYA@186807|Peptococcaceae	186801|Clostridia	L	TIGRFAM single-stranded-DNA-specific exonuclease RecJ	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1,Helicase_C
k59_51525_2	760192.Halhy_2193	3.12e-24	103.0	COG0577@1|root,COG0577@2|Bacteria,4NDUK@976|Bacteroidetes,1IW4Z@117747|Sphingobacteriia	976|Bacteroidetes	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_1551140_1	1459636.NTE_01355	2.72e-103	319.0	COG1215@1|root,arCOG01389@2157|Archaea,41SDD@651137|Thaumarchaeota	651137|Thaumarchaeota	M	Glycosyl transferase family group 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
k59_773632_1	1163408.UU9_04482	7.21e-34	129.0	COG0531@1|root,COG0531@2|Bacteria,1MXNJ@1224|Proteobacteria,1RY8P@1236|Gammaproteobacteria,1XBX9@135614|Xanthomonadales	135614|Xanthomonadales	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
k59_773646_1	1123518.ARWI01000001_gene2117	7.01e-45	160.0	COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,1RMXY@1236|Gammaproteobacteria,46048@72273|Thiotrichales	72273|Thiotrichales	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
k59_107580_1	384765.SIAM614_24577	2.34e-73	241.0	COG3605@1|root,COG3605@2|Bacteria,1QTTV@1224|Proteobacteria,2TR3Z@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Belongs to the PEP-utilizing enzyme family	ptsP	-	2.7.3.9	ko:K08484	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	GAF,GAF_2,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
k59_1388943_1	1405.DJ92_3266	6.3e-10	59.7	COG1226@1|root,COG1226@2|Bacteria,1VCJJ@1239|Firmicutes,4HM5T@91061|Bacilli,1ZHZW@1386|Bacillus	91061|Bacilli	P	Ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
k59_1720501_1	926550.CLDAP_31110	9.04e-56	184.0	COG1173@1|root,COG1173@2|Bacteria	2|Bacteria	P	ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	ko:K02034,ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1,OppC_N
k59_773664_1	998088.B565_0308	5.08e-08	53.9	COG1660@1|root,COG1660@2|Bacteria,1MVX6@1224|Proteobacteria,1RNJX@1236|Gammaproteobacteria,1Y3QS@135624|Aeromonadales	135624|Aeromonadales	S	Displays ATPase and GTPase activities	-	-	-	ko:K06958	-	-	-	-	ko00000,ko03019	-	-	-	ATP_bind_2
k59_773664_2	1243664.CAVL020000037_gene1033	4.33e-30	119.0	COG0391@1|root,COG0391@2|Bacteria,1TPNV@1239|Firmicutes,4HA0Z@91061|Bacilli,1ZB2R@1386|Bacillus	91061|Bacilli	S	Required for morphogenesis under gluconeogenic growth conditions	yvcK	-	-	-	-	-	-	-	-	-	-	-	UPF0052
k59_1442636_1	696369.KI912183_gene884	1.32e-18	82.0	COG1399@1|root,COG1399@2|Bacteria,1VEXU@1239|Firmicutes,24RKT@186801|Clostridia,26257@186807|Peptococcaceae	186801|Clostridia	S	metal-binding protein, possibly nucleic-acid binding protein	-	-	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF177
k59_1442636_2	1444306.JFZC01000004_gene1714	0.000155	43.9	COG0416@1|root,COG0416@2|Bacteria,1TPXS@1239|Firmicutes,4HA0R@91061|Bacilli,26NIV@186821|Sporolactobacillaceae	91061|Bacilli	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
k59_1388964_1	671143.DAMO_2491	3.47e-74	231.0	COG1028@1|root,COG1028@2|Bacteria,2NQBD@2323|unclassified Bacteria	2|Bacteria	IQ	NAD(P)H binding domain of trans-2-enoyl-CoA reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_661651_1	1121405.dsmv_0813	5.38e-90	279.0	COG4962@1|root,COG4962@2|Bacteria,1R7EN@1224|Proteobacteria,42NAK@68525|delta/epsilon subdivisions,2WIYX@28221|Deltaproteobacteria,2MI0I@213118|Desulfobacterales	28221|Deltaproteobacteria	U	PFAM Type II IV secretion system protein	-	-	-	ko:K02283,ko:K03609	-	-	-	-	ko00000,ko02035,ko02044,ko03036,ko04812	-	-	-	CbiA,FHA,T2SSE
k59_107608_1	251221.35212995	1.85e-31	127.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_551877_2	279238.Saro_3541	1.49e-13	68.9	COG2010@1|root,COG2010@2|Bacteria,1N7I9@1224|Proteobacteria,2V1R3@28211|Alphaproteobacteria,2KBX4@204457|Sphingomonadales	204457|Sphingomonadales	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_107628_1	313590.MED134_04654	5.19e-49	175.0	COG0855@1|root,COG0855@2|Bacteria,4NE3P@976|Bacteroidetes,1HX9T@117743|Flavobacteriia,37ERY@326319|Dokdonia	976|Bacteroidetes	P	Polyphosphate kinase middle domain	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
k59_163707_1	379066.GAU_1079	6.19e-39	144.0	COG1228@1|root,COG1228@2|Bacteria,1ZSME@142182|Gemmatimonadetes	142182|Gemmatimonadetes	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_163707_2	1123366.TH3_04979	2.04e-19	80.1	2EGMT@1|root,33ADY@2|Bacteria,1NH3I@1224|Proteobacteria,2UFRY@28211|Alphaproteobacteria,2JUKX@204441|Rhodospirillales	204441|Rhodospirillales	S	Phospholipase_D-nuclease N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_N
k59_110778_1	379066.GAU_1758	1.8e-48	172.0	COG0768@1|root,COG0768@2|Bacteria,1ZSX5@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Penicillin-binding Protein dimerisation domain	-	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
k59_1722920_2	1205680.CAKO01000029_gene5106	2.44e-65	208.0	COG2175@1|root,COG2175@2|Bacteria,1MV5K@1224|Proteobacteria,2TQTZ@28211|Alphaproteobacteria,2JSGW@204441|Rhodospirillales	204441|Rhodospirillales	Q	Taurine catabolism dioxygenase TauD, TfdA family	-	-	-	ko:K22303	-	-	-	-	ko00000,ko01000	-	-	-	TauD
k59_609108_1	435830.HMPREF0045_01800	1.47e-18	92.8	COG0489@1|root,COG3944@1|root,COG0489@2|Bacteria,COG3944@2|Bacteria,2GJ1Y@201174|Actinobacteria,4D49G@85005|Actinomycetales	201174|Actinobacteria	D	biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA_31,CbiA,ParA,Wzz
k59_55033_1	1379270.AUXF01000002_gene1793	8.99e-77	249.0	COG0480@1|root,COG0480@2|Bacteria,1ZTFA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Elongation factor G, domain IV	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU
k59_665270_1	983548.Krodi_0113	1.28e-25	113.0	COG1361@1|root,COG2304@1|root,COG3209@1|root,COG5384@1|root,COG1361@2|Bacteria,COG2304@2|Bacteria,COG3209@2|Bacteria,COG5384@2|Bacteria,4PKBQ@976|Bacteroidetes,1IJ7S@117743|Flavobacteriia,37E64@326319|Dokdonia	976|Bacteroidetes	M	SPTR CHU large protein	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,DUF11,HYR,SdrD_B,SprB
k59_55122_1	479434.Sthe_3347	8.35e-09	62.0	COG2203@1|root,COG4585@1|root,COG2203@2|Bacteria,COG4585@2|Bacteria,2G6ZM@200795|Chloroflexi	200795|Chloroflexi	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA_3
k59_1554430_1	861299.J421_4119	1.62e-19	87.8	COG0534@1|root,COG0534@2|Bacteria,1ZT8D@142182|Gemmatimonadetes	142182|Gemmatimonadetes	V	MatE	-	-	-	-	-	-	-	-	-	-	-	-	MatE
k59_237414_1	1380394.JADL01000002_gene1157	5.75e-91	278.0	COG0683@1|root,COG0683@2|Bacteria,1MV1Z@1224|Proteobacteria,2TRTD@28211|Alphaproteobacteria,2JT93@204441|Rhodospirillales	204441|Rhodospirillales	E	Periplasmic binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
k59_1070995_1	240015.ACP_0677	8.64e-78	249.0	COG2204@1|root,COG2204@2|Bacteria,3Y3HH@57723|Acidobacteria,2JI5D@204432|Acidobacteriia	204432|Acidobacteriia	T	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_737861_1	861299.J421_2767	4.32e-75	256.0	COG0085@1|root,COG0085@2|Bacteria,1ZSQH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_1015901_1	1469613.JT55_04700	2.78e-93	286.0	COG2223@1|root,COG2223@2|Bacteria,1QWUY@1224|Proteobacteria,2TX66@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	COG0477 Permeases of the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1404758_1	512565.AMIS_34430	2.55e-42	154.0	COG0154@1|root,COG0154@2|Bacteria,2GN7F@201174|Actinobacteria,4D8KJ@85008|Micromonosporales	201174|Actinobacteria	J	Amidase	-	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
k59_848123_1	981369.JQMJ01000003_gene7509	2.59e-15	77.0	COG0577@1|root,COG0577@2|Bacteria,2GIRW@201174|Actinobacteria,2NEYZ@228398|Streptacidiphilus	201174|Actinobacteria	V	MacB-like periplasmic core domain	yknZ	-	-	ko:K02004,ko:K05685	ko02010,map02010	M00258,M00709	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.122.1,3.A.1.122.12	-	-	FtsX,MacB_PCD
k59_848123_2	1234593.ANBY01000016_gene754	3.75e-09	58.2	COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,4HFUH@91061|Bacilli,4GXV8@90964|Staphylococcaceae	91061|Bacilli	V	ABC transporter, ATP-binding protein	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1071004_1	1185652.USDA257_c04260	3.41e-36	134.0	COG0582@1|root,COG0582@2|Bacteria,1RBMJ@1224|Proteobacteria,2U0ET@28211|Alphaproteobacteria,4BCUG@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_3,Phage_integrase
k59_237435_1	1379270.AUXF01000006_gene55	2.69e-48	166.0	COG0697@1|root,COG0697@2|Bacteria,1ZUKF@142182|Gemmatimonadetes	142182|Gemmatimonadetes	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_1348926_1	351016.RAZWK3B_15018	6.7e-84	259.0	COG2358@1|root,COG2358@2|Bacteria,1MXW1@1224|Proteobacteria,2TSK2@28211|Alphaproteobacteria,2P1R3@2433|Roseobacter	28211|Alphaproteobacteria	S	TRAP transporter solute receptor, TAXI family protein	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
k59_1015939_1	146922.JOFU01000021_gene2428	1.49e-10	67.0	COG1232@1|root,COG1232@2|Bacteria	2|Bacteria	H	protoporphyrinogen oxidase activity	-	-	1.3.3.15,1.3.3.4	ko:K00231	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03222,R04178	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
k59_70287_1	1532558.JL39_24305	9.59e-33	129.0	COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria,4B7WC@82115|Rhizobiaceae	28211|Alphaproteobacteria	EQ	N-methylhydantoinase A acetone carboxylase, beta subunit	-	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
k59_1571479_1	1120956.JHZK01000005_gene2278	6.24e-91	278.0	COG4177@1|root,COG4177@2|Bacteria,1MWP3@1224|Proteobacteria,2TR99@28211|Alphaproteobacteria,1JNSD@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_793443_1	1530085.A0A077K814_9CAUD	1.87e-41	149.0	4QBAD@10239|Viruses,4QPAI@28883|Caudovirales,4QK7N@10662|Myoviridae	10662|Myoviridae	S	Transposase domain (DUF772)	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_625912_1	1123487.KB892835_gene3636	1.55e-12	72.4	COG2197@1|root,COG2197@2|Bacteria,1P4TD@1224|Proteobacteria,2VMX4@28216|Betaproteobacteria,2KW82@206389|Rhodocyclales	206389|Rhodocyclales	K	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_515310_2	1122603.ATVI01000005_gene3042	8.83e-27	108.0	COG0668@1|root,COG0668@2|Bacteria,1N4UN@1224|Proteobacteria,1T9TX@1236|Gammaproteobacteria,1XBUR@135614|Xanthomonadales	135614|Xanthomonadales	M	Conserved TM helix	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel,TM_helix
k59_1626463_1	385682.AFSL01000102_gene55	4.66e-96	301.0	COG0370@1|root,COG0370@2|Bacteria,4NEII@976|Bacteroidetes,2FNKT@200643|Bacteroidia,3XJ70@558415|Marinilabiliaceae	976|Bacteroidetes	P	FeoA	-	-	-	-	-	-	-	-	-	-	-	-	FeoA,FeoB_C,FeoB_N,Gate
k59_793458_1	358681.BBR47_40420	2.2e-21	95.9	COG2984@1|root,COG2984@2|Bacteria,1TPB0@1239|Firmicutes,4HESK@91061|Bacilli,26RTJ@186822|Paenibacillaceae	91061|Bacilli	S	ABC transporter substrate-binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
k59_293012_1	1128421.JAGA01000002_gene60	2.47e-35	138.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,2NNKQ@2323|unclassified Bacteria	2|Bacteria	E	B12 binding domain	metH	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0030312,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0071944,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.1.13,2.1.1.245,2.1.1.258	ko:K00197,ko:K00548,ko:K15023	ko00270,ko00450,ko00670,ko00680,ko00720,ko01100,ko01110,ko01120,ko01200,ko01230,map00270,map00450,map00670,map00680,map00720,map01100,map01110,map01120,map01200,map01230	M00017,M00357,M00377,M00422	R00946,R02289,R09096,R09365,R10219,R10243	RC00004,RC00035,RC00113,RC01144,RC01241,RC02871,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	iECO103_1326.ECO103_4764,iECUMN_1333.ECUMN_4545	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_404042_1	338963.Pcar_1007	3.01e-79	252.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,42MAV@68525|delta/epsilon subdivisions,2WJC9@28221|Deltaproteobacteria,43TBU@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Belongs to the alpha-IPM synthase homocitrate synthase family	cimA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
k59_793480_2	1379698.RBG1_1C00001G0772	4.48e-30	116.0	COG0437@1|root,COG0437@2|Bacteria,2NPJ0@2323|unclassified Bacteria	2|Bacteria	C	4Fe-4S dicluster domain	hmcB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K00124	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Fer4_11,Fer4_4,Fer4_7
k59_1738161_1	671143.DAMO_2383	5.05e-112	334.0	COG0719@1|root,COG0719@2|Bacteria,2NNKT@2323|unclassified Bacteria	2|Bacteria	O	FeS assembly protein SufB	sufB	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006790,GO:0008150,GO:0008152,GO:0009536,GO:0009842,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0071840	-	ko:K07033,ko:K09014	-	-	-	-	ko00000	-	-	iAPECO1_1312.APECO1_760,iECH74115_1262.ECH74115_2397,iECSF_1327.ECSF_1543,iECSP_1301.ECSP_2250,iUTI89_1310.UTI89_C1875,ic_1306.c2078	UPF0051
k59_460275_1	519989.ECTPHS_09428	1.47e-23	104.0	COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,1RPFM@1236|Gammaproteobacteria,1WXRZ@135613|Chromatiales	135613|Chromatiales	M	PFAM AsmA family protein	-	-	-	ko:K07289	-	-	-	-	ko00000	-	-	-	AsmA
k59_1682628_2	1127673.GLIP_4358	5.23e-52	169.0	COG0225@1|root,COG0225@2|Bacteria,1MVUS@1224|Proteobacteria,1RNWU@1236|Gammaproteobacteria,467HQ@72275|Alteromonadaceae	1236|Gammaproteobacteria	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11,1.8.4.12	ko:K07304,ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR,SelR
k59_793493_1	1479238.JQMZ01000001_gene319	5.3e-23	102.0	COG0836@1|root,COG2942@1|root,COG0836@2|Bacteria,COG2942@2|Bacteria,1MV39@1224|Proteobacteria,2TT0R@28211|Alphaproteobacteria,43X1U@69657|Hyphomonadaceae	28211|Alphaproteobacteria	M	Belongs to the mannose-6-phosphate isomerase type 2 family	manC	-	2.7.7.13,5.3.1.8	ko:K00971,ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00361,M00362	R00885,R01819	RC00002,RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	GlcNAc_2-epim,MannoseP_isomer,NTP_transferase
k59_1127458_1	470.IX87_12725	9.47e-42	154.0	COG0399@1|root,COG0399@2|Bacteria,1MUMJ@1224|Proteobacteria,1RSDY@1236|Gammaproteobacteria,3NKKZ@468|Moraxellaceae	1236|Gammaproteobacteria	M	Putative transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
k59_1293324_1	926569.ANT_06710	1.07e-79	257.0	COG1178@1|root,COG1178@2|Bacteria,2G63A@200795|Chloroflexi	200795|Chloroflexi	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02063	ko02010,map02010	M00191	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.19	-	-	BPD_transp_1
k59_1682637_1	309801.trd_1557	4.08e-93	287.0	COG0174@1|root,COG0174@2|Bacteria,2G5U2@200795|Chloroflexi,27XSZ@189775|Thermomicrobia	189775|Thermomicrobia	E	glutamine synthetase	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
k59_1404876_1	545276.KB898724_gene1976	1.27e-51	176.0	COG0115@1|root,COG0115@2|Bacteria,1MVAT@1224|Proteobacteria,1RPU0@1236|Gammaproteobacteria,1WX40@135613|Chromatiales	135613|Chromatiales	EH	PFAM Aminotransferase, class IV	-	-	2.6.1.21	ko:K00824	ko00310,ko00330,ko00360,ko00472,ko00473,ko01100,map00310,map00330,map00360,map00472,map00473,map01100	-	R01148,R01582,R02459,R02851,R02924,R05053	RC00006,RC00008,RC00025	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_4
k59_15092_1	869210.Marky_0493	1.26e-10	65.5	COG0836@1|root,COG0836@2|Bacteria,1WJFI@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	Nucleotidyl transferase	-	-	2.7.7.13,5.3.1.8	ko:K00971,ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00361,M00362	R00885,R01819	RC00002,RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
k59_625972_1	930166.CD58_20895	1.29e-86	266.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNT1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Belongs to the citrate synthase family	prpC	GO:0003674,GO:0003824,GO:0004108,GO:0006082,GO:0006091,GO:0006113,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016740,GO:0016746,GO:0016829,GO:0016830,GO:0016833,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0036440,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0046459,GO:0046912,GO:0050440,GO:0055114,GO:0071704	2.3.3.5	ko:K01659	ko00640,map00640	-	R00931	RC00004,RC00406,RC02827	ko00000,ko00001,ko01000	-	-	iECED1_1282.ECED1_0365,iECIAI1_1343.ECIAI1_0334,iECIAI39_1322.ECIAI39_0347,iECP_1309.ECP_0408,iECSF_1327.ECSF_0308,iEcE24377_1341.EcE24377A_0357,iJN746.PP_2335,iLF82_1304.LF82_1740,iNRG857_1313.NRG857_01630	Citrate_synt
k59_15094_1	401053.AciPR4_1659	8.14e-14	70.5	COG1846@1|root,COG1846@2|Bacteria,3Y97P@57723|Acidobacteria,2JNFY@204432|Acidobacteriia	204432|Acidobacteriia	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR
k59_570447_1	926569.ANT_19020	1.09e-84	261.0	COG0050@1|root,COG0050@2|Bacteria,2G5KI@200795|Chloroflexi	200795|Chloroflexi	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
k59_625975_2	1211115.ALIQ01000108_gene1230	3.4e-18	89.0	COG3336@1|root,COG3336@2|Bacteria,1RD89@1224|Proteobacteria,2U5U6@28211|Alphaproteobacteria,3NBH9@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG)	-	-	-	ko:K02351	-	-	-	-	ko00000	-	-	-	Caa3_CtaG
k59_1016043_1	706587.Desti_2382	2.03e-48	170.0	COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,42M1C@68525|delta/epsilon subdivisions,2WIZQ@28221|Deltaproteobacteria,2MQZI@213462|Syntrophobacterales	28221|Deltaproteobacteria	EH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
k59_1016043_2	671143.DAMO_3099	1.53e-50	172.0	COG0075@1|root,COG0075@2|Bacteria,2NP52@2323|unclassified Bacteria	2|Bacteria	E	Aminotransferase class-V	-	GO:0001505,GO:0003674,GO:0003824,GO:0004760,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006807,GO:0008150,GO:0008152,GO:0008453,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0019265,GO:0019752,GO:0042133,GO:0042136,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	-	-	-	-	-	-	-	-	-	-	Aminotran_5
k59_181371_1	1242864.D187_001530	5.47e-08	54.7	COG3303@1|root,COG3303@2|Bacteria,1P8CP@1224|Proteobacteria,42MXS@68525|delta/epsilon subdivisions,2WKEK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Seven times multi-haem cytochrome CxxCH	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Multi-haem_cyto
k59_1404918_1	35841.BT1A1_2066	1.2e-22	97.1	COG0204@1|root,COG0204@2|Bacteria,1U8N2@1239|Firmicutes,4HDQR@91061|Bacilli,1ZE5P@1386|Bacillus	91061|Bacilli	I	1-acyl-sn-glycerol-3-phosphate acyltransferase	plsC	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
k59_1682678_1	768671.ThimaDRAFT_2118	7.7e-62	203.0	COG1262@1|root,COG1262@2|Bacteria,1MUNC@1224|Proteobacteria,1RQI4@1236|Gammaproteobacteria,1WVY9@135613|Chromatiales	135613|Chromatiales	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2,FGE-sulfatase
k59_1460757_1	1200792.AKYF01000005_gene3309	3.26e-77	251.0	COG0480@1|root,COG0480@2|Bacteria,1TPF9@1239|Firmicutes,4HAB8@91061|Bacilli,26RH1@186822|Paenibacillaceae	91061|Bacilli	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_293106_1	234267.Acid_3054	8.13e-09	62.4	COG0577@1|root,COG0577@2|Bacteria,3Y3XC@57723|Acidobacteria	2|Bacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_570492_1	1379270.AUXF01000001_gene2373	2.3e-66	215.0	COG2801@1|root,COG2801@2|Bacteria,1ZUZC@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Integrase core domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve_3
k59_1682695_1	880073.Calab_0802	4.28e-60	201.0	COG0591@1|root,COG0591@2|Bacteria,2NPAX@2323|unclassified Bacteria	2|Bacteria	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K11928	-	-	-	-	ko00000,ko02000	2.A.21.2	-	-	SSF
k59_1571607_1	314231.FP2506_01010	9.38e-92	289.0	COG4784@1|root,COG4784@2|Bacteria,1QTT7@1224|Proteobacteria,2TTU7@28211|Alphaproteobacteria,2PJ8T@255475|Aurantimonadaceae	28211|Alphaproteobacteria	S	Peptidase family M48	MA20_40030	-	-	-	-	-	-	-	-	-	-	-	LysM,Peptidase_M48
k59_1182484_1	555778.Hneap_0621	1.14e-45	167.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RN8P@1236|Gammaproteobacteria,1WXNN@135613|Chromatiales	135613|Chromatiales	F	PFAM glycosyl transferase family 35	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
k59_960077_1	504832.OCAR_7754	1.43e-31	115.0	COG0789@1|root,COG0789@2|Bacteria,1MZ3P@1224|Proteobacteria,2UC95@28211|Alphaproteobacteria,3JZWN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	helix_turn_helix, mercury resistance	-	-	-	ko:K08365	-	-	-	-	ko00000,ko03000	-	-	-	MerR,MerR-DNA-bind,MerR_1
k59_960077_2	258594.RPA0881	1.85e-16	78.6	COG0385@1|root,COG0385@2|Bacteria,1MVXH@1224|Proteobacteria,2TTE0@28211|Alphaproteobacteria,3JTHY@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Bile acid	-	-	-	ko:K03453	-	-	-	-	ko00000	2.A.28	-	-	SBF
k59_682834_1	986075.CathTA2_1728	1.57e-68	216.0	COG0819@1|root,COG0819@2|Bacteria,1TPK0@1239|Firmicutes,4HD73@91061|Bacilli	91061|Bacilli	K	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway	tenA	-	3.5.99.2	ko:K03707	ko00730,ko01100,map00730,map01100	-	R02133,R09993	RC00224,RC00652,RC02832	ko00000,ko00001,ko01000,ko03000	-	-	-	TENA_THI-4
k59_1293432_1	251221.35211983	3.33e-43	160.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_960094_1	32057.KB217483_gene10086	1.64e-36	142.0	COG5421@1|root,COG5421@2|Bacteria,1G02P@1117|Cyanobacteria,1HJTW@1161|Nostocales	1117|Cyanobacteria	L	COGs COG5421 Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4277
k59_960096_1	1379270.AUXF01000002_gene1585	7.74e-59	202.0	COG0515@1|root,COG0515@2|Bacteria,1ZUMJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
k59_1016132_1	379066.GAU_0001	5.98e-74	238.0	COG0593@1|root,COG0593@2|Bacteria,1ZSQ2@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
k59_793628_1	926569.ANT_03640	1.06e-49	168.0	COG0746@1|root,COG0746@2|Bacteria	2|Bacteria	H	molybdenum cofactor guanylyltransferase activity	mobA	GO:0003674,GO:0003824,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0071704,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.7.77	ko:K03752,ko:K13818	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
k59_793628_2	580327.Tthe_0377	1.77e-08	55.5	COG5322@1|root,COG5322@2|Bacteria,1TQ2E@1239|Firmicutes,24A1Y@186801|Clostridia,42EUN@68295|Thermoanaerobacterales	186801|Clostridia	S	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1016142_1	876269.ARWA01000001_gene3681	7.97e-82	267.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2TRZD@28211|Alphaproteobacteria,3NC0G@45404|Beijerinckiaceae	28211|Alphaproteobacteria	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.6	ko:K01535	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.3.3	-	-	Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k59_70495_1	1121904.ARBP01000004_gene1059	0.000743	44.3	COG0577@1|root,COG0577@2|Bacteria,4NDUK@976|Bacteroidetes,47NTJ@768503|Cytophagia	976|Bacteroidetes	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_1406556_1	861299.J421_2914	6.63e-32	120.0	COG1606@1|root,COG1606@2|Bacteria	2|Bacteria	L	tRNA processing	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	Asn_synthase,NAD_synthase
k59_795142_1	251229.Chro_0877	9.17e-15	77.4	COG1132@1|root,COG1132@2|Bacteria,1G1JY@1117|Cyanobacteria,3VINJ@52604|Pleurocapsales	1117|Cyanobacteria	V	ABC-type multidrug transport system ATPase and permease	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_684519_1	386415.NT01CX_1467	4.27e-18	83.6	COG1268@1|root,COG1268@2|Bacteria,1VAY6@1239|Firmicutes,24HU5@186801|Clostridia,36DWS@31979|Clostridiaceae	186801|Clostridia	S	hmm pf02632	bioY	-	-	ko:K03523	ko02010,map02010	M00581,M00582	-	-	ko00000,ko00001,ko00002,ko02000	2.A.88.1,2.A.88.2	-	-	BioY
k59_684519_2	525368.HMPREF0591_2258	1.76e-12	67.0	COG1804@1|root,COG1804@2|Bacteria,2GMIW@201174|Actinobacteria,23787@1762|Mycobacteriaceae	201174|Actinobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_795151_1	384765.SIAM614_06213	7.91e-41	142.0	COG1670@1|root,COG1670@2|Bacteria,1MVG4@1224|Proteobacteria,2TUIK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	rimJ	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
k59_1462298_1	1381751.JAJB01000033_gene738	5.22e-16	83.2	COG1105@1|root,COG1105@2|Bacteria,2GK7E@201174|Actinobacteria,4FB0Q@85019|Brevibacteriaceae	201174|Actinobacteria	G	pfkB family carbohydrate kinase	fruK	-	2.7.1.11,2.7.1.56	ko:K00882,ko:K16370	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00345	R00756,R02071,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
k59_405891_1	324602.Caur_0234	1.73e-32	127.0	COG0183@1|root,COG0183@2|Bacteria,2G63J@200795|Chloroflexi,3750U@32061|Chloroflexia	32061|Chloroflexia	I	Thiolase, N-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_N
k59_16917_1	749927.AMED_5528	8.34e-13	72.4	COG2141@1|root,COG2141@2|Bacteria,2GJI7@201174|Actinobacteria,4E9R4@85010|Pseudonocardiales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_627596_1	1128421.JAGA01000003_gene3444	2.4e-78	248.0	COG0165@1|root,COG0165@2|Bacteria,2NP70@2323|unclassified Bacteria	2|Bacteria	E	argininosuccinate lyase	argH	GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0030312,GO:0040007,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.1,4.3.2.1	ko:K01755,ko:K14681	ko00220,ko00250,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map01100,map01110,map01130,map01210,map01230	M00028,M00029,M00844,M00845	R00259,R01086	RC00004,RC00064,RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iJN678.argH	ASL_C2,Lyase_1
k59_1184108_1	1128421.JAGA01000003_gene2923	1.5e-22	96.3	COG1053@1|root,COG1053@2|Bacteria,2NQMR@2323|unclassified Bacteria	2|Bacteria	C	Fumarate reductase flavoprotein C-term	sdhA	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_1184108_2	1313172.YM304_07470	1.44e-38	138.0	28HIR@1|root,2Z7U4@2|Bacteria,2GN2S@201174|Actinobacteria	201174|Actinobacteria	S	succinate dehydrogenase	sdhC	-	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
k59_1406604_1	1211814.CAPG01000036_gene1815	9.37e-33	127.0	COG0128@1|root,COG0128@2|Bacteria,1TPIH@1239|Firmicutes,4HBHZ@91061|Bacilli,1ZBP0@1386|Bacillus	91061|Bacilli	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
k59_1072761_1	1122970.AUHC01000009_gene319	3.61e-05	50.4	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2TQVK@28211|Alphaproteobacteria,2K25R@204457|Sphingomonadales	204457|Sphingomonadales	C	aerobic-type carbon monoxide dehydrogenase, large subunit CoxL	-	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C2
k59_462127_1	1121377.KB906398_gene2693	1.35e-30	119.0	COG1028@1|root,COG1028@2|Bacteria,1WM8P@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_961825_1	1500897.JQNA01000002_gene4620	5.18e-08	56.6	COG3437@1|root,COG4585@1|root,COG3437@2|Bacteria,COG4585@2|Bacteria,1RGET@1224|Proteobacteria,2VPRS@28216|Betaproteobacteria,1KHSR@119060|Burkholderiaceae	28216|Betaproteobacteria	T	Multi-sensor signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA_3,PAS,PAS_4,PAS_9,Reg_prop,Response_reg,Y_Y_Y
k59_572075_1	264951.V5G545	3.27e-08	61.6	COG4581@1|root,KOG0947@2759|Eukaryota,KOG1991@2759|Eukaryota,38BTP@33154|Opisthokonta,3NUCU@4751|Fungi,3QJX6@4890|Ascomycota,20D68@147545|Eurotiomycetes,3S6SC@5042|Eurotiales	4751|Fungi	A	DEAD DEAH box RNA helicase (Ski2)	SKI2	GO:0000184,GO:0000288,GO:0000291,GO:0000956,GO:0003674,GO:0003676,GO:0003723,GO:0003724,GO:0003729,GO:0003824,GO:0004004,GO:0004386,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005730,GO:0005737,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0006986,GO:0007154,GO:0007165,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010033,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019222,GO:0019439,GO:0023052,GO:0030968,GO:0031974,GO:0031981,GO:0032991,GO:0033554,GO:0034427,GO:0034620,GO:0034641,GO:0034655,GO:0034976,GO:0035966,GO:0035967,GO:0042221,GO:0042623,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043928,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055087,GO:0060255,GO:0065007,GO:0070013,GO:0070035,GO:0070478,GO:0070481,GO:0070887,GO:0071310,GO:0071704,GO:0090304,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901363,GO:1901575	-	ko:K12599	ko03018,map03018	M00392	-	-	ko00000,ko00001,ko00002,ko01000,ko03019	-	-	-	DEAD,DSHCT,Helicase_C,rRNA_proc-arch
k59_517200_1	1004785.AMBLS11_16780	3.45e-23	96.7	COG2884@1|root,COG2884@2|Bacteria,1MVQ4@1224|Proteobacteria,1RMZA@1236|Gammaproteobacteria,464ZE@72275|Alteromonadaceae	1236|Gammaproteobacteria	D	ATPase involved in cell division	ftsE	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008144,GO:0008150,GO:0009898,GO:0009987,GO:0016020,GO:0017076,GO:0019897,GO:0019898,GO:0030554,GO:0031234,GO:0032153,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050896,GO:0051301,GO:0071944,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
k59_572081_1	663610.JQKO01000010_gene2194	6.03e-61	195.0	COG0566@1|root,COG0566@2|Bacteria,1MWCM@1224|Proteobacteria,2TUG7@28211|Alphaproteobacteria,3N9XP@45404|Beijerinckiaceae	28211|Alphaproteobacteria	J	RNA 2'-O ribose methyltransferase substrate binding	rlmB	-	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
k59_1017931_1	234267.Acid_7177	1.48e-30	124.0	COG0577@1|root,COG0577@2|Bacteria,3Y402@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_86543_2	926550.CLDAP_07690	8.78e-30	117.0	COG1131@1|root,COG1131@2|Bacteria,2G7U7@200795|Chloroflexi	200795|Chloroflexi	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_922885_2	756272.Plabr_3782	2.32e-05	48.9	COG0526@1|root,COG0526@2|Bacteria,2IXKJ@203682|Planctomycetes	203682|Planctomycetes	CO	EF hand	-	-	-	-	-	-	-	-	-	-	-	-	Cu2_monoox_C,EF-hand_5,Redoxin
k59_1641883_2	243230.DR_0918	1.07e-14	74.3	COG0714@1|root,COG0714@2|Bacteria,1WJ11@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
k59_1087875_2	107635.AZUO01000005_gene4355	5.03e-38	139.0	COG0457@1|root,COG4633@1|root,COG0457@2|Bacteria,COG4633@2|Bacteria,1N1UQ@1224|Proteobacteria,2UEDS@28211|Alphaproteobacteria,370RZ@31993|Methylocystaceae	28211|Alphaproteobacteria	S	Cupredoxin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1
k59_31014_1	1410625.JHWK01000003_gene1576	1.23e-21	95.5	COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,24888@186801|Clostridia,27IQK@186928|unclassified Lachnospiraceae	186801|Clostridia	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
k59_31014_2	1313172.YM304_12560	5.32e-56	187.0	COG0482@1|root,COG0482@2|Bacteria,2GIUQ@201174|Actinobacteria,4CMY8@84992|Acidimicrobiia	84992|Acidimicrobiia	J	tRNA methyl transferase	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
k59_1531821_1	765869.BDW_08815	2.24e-43	160.0	COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,42PCH@68525|delta/epsilon subdivisions,2MTEB@213481|Bdellovibrionales,2WMQM@28221|Deltaproteobacteria	213481|Bdellovibrionales	M	PFAM Three-deoxy-D-manno-octulosonic-acid transferase	kdtA	-	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30	-	Glycos_transf_N
k59_1753420_1	643562.Daes_2649	3.89e-38	147.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42MFH@68525|delta/epsilon subdivisions,2WIRW@28221|Deltaproteobacteria,2M7VS@213115|Desulfovibrionales	28221|Deltaproteobacteria	KT	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS,PAS_4,PAS_9,Response_reg,Sigma54_activat
k59_1531823_1	1121104.AQXH01000001_gene1545	5.14e-07	57.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,4NGU2@976|Bacteroidetes,1IWHI@117747|Sphingobacteriia	976|Bacteroidetes	M	Tricorn protease PDZ domain	-	-	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
k59_753670_1	118797.XP_007468251.1	7.29e-49	179.0	COG0085@1|root,KOG0214@2759|Eukaryota	2759|Eukaryota	K	DNA-directed 5'-3' RNA polymerase activity	rpoB	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009536,GO:0030880,GO:0032991,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03043,ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5,RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_141594_1	1278073.MYSTI_04098	8.18e-60	194.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42PIB@68525|delta/epsilon subdivisions,2WKFC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	ABC transporter	ybhF-N	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
k59_197278_2	861299.J421_2074	8.69e-16	82.4	COG1668@1|root,COG1668@2|Bacteria,1ZTID@142182|Gemmatimonadetes	142182|Gemmatimonadetes	CP	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
k59_586483_1	671143.DAMO_2838	7.96e-17	85.9	COG4191@1|root,COG4191@2|Bacteria,2NQ9P@2323|unclassified Bacteria	2|Bacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
k59_141609_1	1463900.JOIX01000001_gene6354	2.39e-59	204.0	COG1032@1|root,COG1032@2|Bacteria,2IC05@201174|Actinobacteria	201174|Actinobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
k59_531486_1	98439.AJLL01000057_gene304	7.06e-29	112.0	COG0194@1|root,COG0194@2|Bacteria,1G515@1117|Cyanobacteria,1JJ72@1189|Stigonemataceae	1117|Cyanobacteria	F	Guanylate kinase homologues.	gmk	GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
k59_253004_1	1255043.TVNIR_1670	7.51e-37	138.0	COG4257@1|root,COG4257@2|Bacteria,1QR8W@1224|Proteobacteria,1RQM4@1236|Gammaproteobacteria,1X0DH@135613|Chromatiales	135613|Chromatiales	V	Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid	-	-	-	ko:K18235	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	-
k59_1477201_1	498761.HM1_0721	2.91e-64	221.0	COG1197@1|root,COG1197@2|Bacteria,1TPF1@1239|Firmicutes,248D8@186801|Clostridia	186801|Clostridia	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_809661_2	1122134.KB893650_gene1119	1.62e-28	103.0	COG1476@1|root,COG1476@2|Bacteria,1N6SS@1224|Proteobacteria,1SCI8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Transcriptional	-	-	-	ko:K07729	-	-	-	-	ko00000,ko03000	-	-	-	HTH_19,HTH_3
k59_922939_1	1238182.C882_3169	2.61e-92	295.0	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,2TQMY@28211|Alphaproteobacteria,2JQK4@204441|Rhodospirillales	204441|Rhodospirillales	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc
k59_922946_1	570952.ATVH01000011_gene10	1.12e-11	67.8	COG2854@1|root,COG2854@2|Bacteria,1NKFA@1224|Proteobacteria,2UAPV@28211|Alphaproteobacteria,2JSSQ@204441|Rhodospirillales	204441|Rhodospirillales	Q	COG2854 ABC-type transport system involved in resistance to organic solvents, auxiliary component	-	-	-	ko:K07323	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	MlaC
k59_1753466_1	1298863.AUEP01000008_gene1246	5.9e-153	447.0	COG1233@1|root,COG1233@2|Bacteria,2GMUC@201174|Actinobacteria,4DTJJ@85009|Propionibacteriales	201174|Actinobacteria	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
k59_1753466_2	1122609.AUGT01000009_gene3349	6.06e-48	166.0	COG0404@1|root,COG0404@2|Bacteria,2I8C4@201174|Actinobacteria,4DTFF@85009|Propionibacteriales	201174|Actinobacteria	E	Glycine cleavage T-protein C-terminal barrel domain	-	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1989,GCV_T,GCV_T_C
k59_863823_1	1379270.AUXF01000004_gene3311	6.37e-103	313.0	COG4867@1|root,COG4867@2|Bacteria,1ZT0B@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2
k59_699292_1	485913.Krac_10556	1.56e-43	160.0	COG4585@1|root,COG4585@2|Bacteria,2G88D@200795|Chloroflexi	200795|Chloroflexi	T	histidine kinase, dimerisation and phosphoacceptor region	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GAF_3,HATPase_c,HisKA_3
k59_977537_1	661478.OP10G_4010	2.37e-51	184.0	COG3391@1|root,COG3511@1|root,COG3391@2|Bacteria,COG3511@2|Bacteria	2|Bacteria	M	phospholipase C	-	-	-	-	-	-	-	-	-	-	-	-	DUF1735,F5_F8_type_C,Lactonase,Phosphoesterase
k59_253045_2	702113.PP1Y_AT32980	5.15e-10	60.8	COG1506@1|root,COG1506@2|Bacteria,1R968@1224|Proteobacteria,2TXT1@28211|Alphaproteobacteria,2K2XT@204457|Sphingomonadales	204457|Sphingomonadales	E	Tannase and feruloyl esterase	-	-	-	-	-	-	-	-	-	-	-	-	Tannase
k59_1700260_1	926569.ANT_28990	6.45e-38	139.0	COG0448@1|root,COG0448@2|Bacteria,2G66Q@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
k59_420390_1	1096769.Pelub83DRAFT_0474	1.81e-71	232.0	COG2211@1|root,COG2211@2|Bacteria,1MWSH@1224|Proteobacteria,2U0DN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	COG0477 Permeases of the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	BT1
k59_1033968_1	273057.SSO2128	1.06e-43	155.0	COG1144@1|root,arCOG01604@2157|Archaea,2XRKM@28889|Crenarchaeota	28889|Crenarchaeota	C	Pyruvate synthase delta chain (Pyruvic-ferredoxin oxidoreductase delta chain) (PorD-like)	-	-	1.2.7.1	ko:K00171	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_21
k59_1420974_1	666686.B1NLA3E_10455	7.25e-08	53.9	COG0477@1|root,COG2814@2|Bacteria,1TS6K@1239|Firmicutes,4HB1V@91061|Bacilli,1ZB90@1386|Bacillus	91061|Bacilli	EGP	COG0477 Permeases of the major facilitator superfamily	tetA_3	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,Sugar_tr
k59_1420974_2	243230.DR_0217	3.1e-45	154.0	COG2897@1|root,COG2897@2|Bacteria,1WI0D@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	Sulfurtransferase	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
k59_809726_1	1379270.AUXF01000005_gene661	3.97e-81	268.0	COG0060@1|root,COG0060@2|Bacteria,1ZSKS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
k59_1144125_1	1089546.AQUI01000002_gene3445	5.77e-78	244.0	COG0604@1|root,COG0604@2|Bacteria,2GKHW@201174|Actinobacteria,408Z2@622450|Actinopolysporales	201174|Actinobacteria	C	Zinc-binding dehydrogenase	qor	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_586582_1	1172188.KB911824_gene3336	8.21e-17	81.3	COG3557@1|root,COG3557@2|Bacteria,2IQ8M@201174|Actinobacteria,4FHFG@85021|Intrasporangiaceae	201174|Actinobacteria	J	Protein of unknown function (DUF402)	-	-	-	ko:K07586	-	-	-	-	ko00000	-	-	-	DUF402
k59_1365903_2	926569.ANT_29910	4.48e-20	89.7	COG0746@1|root,COG0746@2|Bacteria,2G786@200795|Chloroflexi	200795|Chloroflexi	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3,NTPase_1
k59_1642008_2	935840.JAEQ01000006_gene2550	6.25e-28	105.0	COG1529@1|root,COG1529@2|Bacteria	2|Bacteria	C	xanthine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C2
k59_364386_1	1123322.KB904671_gene2867	4.19e-24	107.0	COG4585@1|root,COG4585@2|Bacteria,2GIXR@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_3
k59_641683_1	1122132.AQYH01000007_gene2245	4.73e-142	427.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,2TRKI@28211|Alphaproteobacteria,4B9AX@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_31163_1	40571.JOEA01000015_gene205	6.68e-15	76.3	COG4447@1|root,COG4447@2|Bacteria,2GM8J@201174|Actinobacteria,4DZ4D@85010|Pseudonocardiales	201174|Actinobacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR,BNR_6
k59_31163_2	935866.JAER01000032_gene2397	2.47e-12	70.9	COG0334@1|root,COG0334@2|Bacteria,2GKXG@201174|Actinobacteria,4DTPS@85009|Propionibacteriales	201174|Actinobacteria	E	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase	gdhA2	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
k59_364410_1	711393.AYRX01000111_gene5663	2.08e-07	57.0	COG0517@1|root,COG2823@1|root,COG0517@2|Bacteria,COG2823@2|Bacteria,2GKSH@201174|Actinobacteria	201174|Actinobacteria	C	Cbs domain	-	-	-	-	-	-	-	-	-	-	-	-	BON,CBS
k59_1642030_1	95619.PM1_0207670	1.05e-56	190.0	COG0001@1|root,COG0001@2|Bacteria,1NGKF@1224|Proteobacteria	1224|Proteobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_923057_1	716928.AJQT01000001_gene263	5.83e-20	86.3	2B3U0@1|root,31WHT@2|Bacteria,1RIS2@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_923057_2	1303518.CCALI_00365	0.000329	43.9	COG1249@1|root,COG1249@2|Bacteria	2|Bacteria	C	cell redox homeostasis	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_1200349_1	1123023.JIAI01000006_gene204	2.7e-15	78.6	2E0VD@1|root,32WCN@2|Bacteria,2ITDY@201174|Actinobacteria	201174|Actinobacteria	S	Vitamin K-dependent gamma-carboxylase	-	-	-	-	-	-	-	-	-	-	-	-	VKG_Carbox
k59_1145815_1	479432.Sros_5656	1.8e-08	55.8	COG2377@1|root,COG2377@2|Bacteria,2GNAM@201174|Actinobacteria,4EGF6@85012|Streptosporangiales	201174|Actinobacteria	O	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling	anmK	-	2.7.1.170	ko:K09001	-	-	-	-	ko00000,ko01000	-	-	-	AnmK
k59_1367575_1	1380394.JADL01000003_gene5040	1.54e-59	193.0	COG1024@1|root,COG1024@2|Bacteria,1PU1Q@1224|Proteobacteria,2TSW6@28211|Alphaproteobacteria,2JS2P@204441|Rhodospirillales	204441|Rhodospirillales	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
k59_1702102_1	316274.Haur_2801	3.12e-20	94.4	COG0628@1|root,COG0628@2|Bacteria	2|Bacteria	D	permease	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
k59_1200362_1	935261.JAGL01000008_gene2347	2.14e-54	190.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TVI3@28211|Alphaproteobacteria,43NB3@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	-	-	-	-	-	-	-	-	-	TctA
k59_1755039_1	1122222.AXWR01000015_gene1163	1.09e-28	120.0	COG1164@1|root,COG1164@2|Bacteria,1WIRX@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Oligoendopeptidase, pepF M3 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M3,Peptidase_M3_N
k59_1533664_1	471855.Shel_23630	7.85e-06	51.6	COG0265@1|root,COG0265@2|Bacteria,2GJ96@201174|Actinobacteria,4CV2A@84998|Coriobacteriia	84998|Coriobacteriia	O	PDZ DHR GLGF domain protein	-	-	-	ko:K08372	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Trypsin_2
k59_143308_1	1184267.A11Q_1618	1.49e-86	263.0	COG3677@1|root,COG3677@2|Bacteria,1NUJD@1224|Proteobacteria,42ZJP@68525|delta/epsilon subdivisions,2MTM1@213481|Bdellovibrionales,2WUVR@28221|Deltaproteobacteria	213481|Bdellovibrionales	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_366054_1	1120934.KB894407_gene5183	6.56e-07	57.0	COG0823@1|root,COG0823@2|Bacteria,2GMNT@201174|Actinobacteria,4DY93@85010|Pseudonocardiales	201174|Actinobacteria	U	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,PD40
k59_1312707_1	1056820.KB900629_gene1713	1.17e-14	78.6	COG2885@1|root,COG2885@2|Bacteria,1P1AB@1224|Proteobacteria,1RMCQ@1236|Gammaproteobacteria,2PQ00@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	M	OmpA family	oprF	-	-	-	-	-	-	-	-	-	-	-	OmpA
k59_701064_2	273068.TTE1633	2.61e-07	53.5	COG0745@1|root,COG0745@2|Bacteria,1TPWS@1239|Firmicutes,25AZ2@186801|Clostridia,42JDU@68295|Thermoanaerobacterales	186801|Clostridia	K	Response regulator receiver	phoP	-	-	ko:K02483,ko:K07658,ko:K07668	ko02020,map02020	M00434,M00459	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_1533687_1	414684.RC1_2134	0.000417	42.0	COG0661@1|root,COG0661@2|Bacteria,1MW1J@1224|Proteobacteria,2TSHG@28211|Alphaproteobacteria,2JPSK@204441|Rhodospirillales	204441|Rhodospirillales	S	ABC1 family	-	-	-	-	-	-	-	-	-	-	-	-	ABC1
k59_1533687_2	1231190.NA8A_01145	1.68e-35	135.0	COG0665@1|root,COG0665@2|Bacteria,1MVIZ@1224|Proteobacteria,2TSQI@28211|Alphaproteobacteria,43J2Z@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	FAD dependent oxidoreductase	-	-	1.4.5.1	ko:K00285	ko00360,map00360	-	R01374,R09493	RC00006,RC00025	ko00000,ko00001,ko01000	-	-	-	DAO
k59_1755065_1	1121422.AUMW01000011_gene147	7.76e-59	200.0	COG1171@1|root,COG1171@2|Bacteria,1TP22@1239|Firmicutes,248D5@186801|Clostridia,2615A@186807|Peptococcaceae	186801|Clostridia	E	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA	ilvA	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT_4,PALP
k59_1035721_1	1131814.JAFO01000001_gene3975	2.3e-35	137.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TSB1@28211|Alphaproteobacteria,3EY38@335928|Xanthobacteraceae	28211|Alphaproteobacteria	EH	Thiamine pyrophosphate enzyme, central domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_1257859_1	765420.OSCT_2486	1.39e-62	201.0	COG0357@1|root,COG0357@2|Bacteria,2G6HF@200795|Chloroflexi,375M8@32061|Chloroflexia	32061|Chloroflexia	J	Specifically methylates the N7 position of a guanine in 16S rRNA	rsmG	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
k59_1089717_1	1184267.A11Q_562	1.1e-13	73.9	COG0741@1|root,COG0741@2|Bacteria,1MWKE@1224|Proteobacteria,42M5C@68525|delta/epsilon subdivisions,2MTN7@213481|Bdellovibrionales,2WJ54@28221|Deltaproteobacteria	213481|Bdellovibrionales	M	Lytic transglycosylase catalytic	mltD2	-	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	LysM,SLT
k59_755591_2	1089546.AQUI01000002_gene523	0.000579	47.4	COG1680@1|root,COG1680@2|Bacteria,2GJQG@201174|Actinobacteria,408IK@622450|Actinopolysporales	201174|Actinobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,Peptidase_M6
k59_1035748_1	1089552.KI911559_gene1365	2.64e-46	160.0	COG1028@1|root,COG4334@1|root,COG1028@2|Bacteria,COG4334@2|Bacteria,1R413@1224|Proteobacteria,2TW0W@28211|Alphaproteobacteria,2JSVN@204441|Rhodospirillales	204441|Rhodospirillales	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_1035748_2	160799.PBOR_13460	5.58e-06	52.8	COG3250@1|root,COG3250@2|Bacteria,1TPDC@1239|Firmicutes,4HANW@91061|Bacilli,26QRR@186822|Paenibacillaceae	91061|Bacilli	G	beta-galactosidase	-	-	3.2.1.23	ko:K01190,ko:K12111	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	Bgal_small_N,DUF4981,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
k59_1755098_1	1116472.MGMO_55c00240	1.12e-06	54.3	COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,1RNB8@1236|Gammaproteobacteria,1XFQY@135618|Methylococcales	135618|Methylococcales	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
k59_1200432_1	926569.ANT_03540	1.67e-29	108.0	COG1839@1|root,COG1839@2|Bacteria,2G6BH@200795|Chloroflexi	200795|Chloroflexi	S	Adenosine specific kinase	-	-	-	ko:K09129	-	-	-	-	ko00000	-	-	-	Adenosine_kin
k59_1200432_2	713586.KB900536_gene2038	1.37e-06	51.2	COG0589@1|root,COG0589@2|Bacteria,1NBKV@1224|Proteobacteria,1SHMY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Universal stress protein family	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE,Usp
k59_588332_1	397945.Aave_2985	1.82e-30	125.0	COG1640@1|root,COG3280@1|root,COG1640@2|Bacteria,COG3280@2|Bacteria,1QTVJ@1224|Proteobacteria,2WGPV@28216|Betaproteobacteria,4AD3R@80864|Comamonadaceae	28216|Betaproteobacteria	G	SMART alpha amylase catalytic sub domain	treY	-	2.4.1.25,5.4.99.15	ko:K00705,ko:K06044	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01824,R05196,R09995	RC00049	ko00000,ko00001,ko00002,ko01000	-	GH13,GH77	-	Alpha-amylase,Glyco_hydro_77
k59_383268_1	1047013.AQSP01000111_gene1656	5.11e-32	128.0	COG1297@1|root,COG1297@2|Bacteria,2NPP0@2323|unclassified Bacteria	2|Bacteria	S	OPT oligopeptide transporter protein	oliA	GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0008150,GO:0016020,GO:0022857,GO:0051179,GO:0051234,GO:0055085	-	-	-	-	-	-	-	-	-	-	OPT
k59_548856_1	595460.RRSWK_02241	6.49e-14	71.6	COG4301@1|root,COG4301@2|Bacteria,2IXEH@203682|Planctomycetes	203682|Planctomycetes	S	Histidine-specific methyltransferase, SAM-dependent	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_33
k59_718445_1	1335757.SPICUR_01325	3.71e-34	122.0	2CJPW@1|root,32SAH@2|Bacteria,1NAJ3@1224|Proteobacteria,1SAPE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_269085_1	457570.Nther_1496	1.39e-53	189.0	COG0249@1|root,COG0249@2|Bacteria,1TPRJ@1239|Firmicutes,248GI@186801|Clostridia	186801|Clostridia	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
k59_1547986_1	446462.Amir_0490	1.28e-06	50.1	COG0477@1|root,COG2814@2|Bacteria,2I2EY@201174|Actinobacteria,4DY4V@85010|Pseudonocardiales	201174|Actinobacteria	EGP	Arabinose efflux permease family protein	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
k59_1547986_2	1064537.AGSO01000011_gene2763	1.88e-09	58.5	COG1846@1|root,COG1846@2|Bacteria,2HPHP@201174|Actinobacteria,4FCY3@85020|Dermabacteraceae	201174|Actinobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR
k59_329247_1	391603.FBALC1_00460	9.12e-80	245.0	COG1208@1|root,COG1208@2|Bacteria,4NE97@976|Bacteroidetes,1HYFQ@117743|Flavobacteriia	976|Bacteroidetes	JM	dTDP-glucose pyrophosphorylase	rffH	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
k59_1106087_1	566466.NOR53_3522	5.08e-84	270.0	COG0457@1|root,COG0457@2|Bacteria,1MYQU@1224|Proteobacteria,1RWMR@1236|Gammaproteobacteria,1JABK@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_12,TPR_7
k59_1215985_1	1089552.KI911559_gene1255	3.21e-15	76.3	COG4520@1|root,COG4520@2|Bacteria,1N0YF@1224|Proteobacteria,2UA8D@28211|Alphaproteobacteria,2JSUH@204441|Rhodospirillales	204441|Rhodospirillales	M	17 kDa outer membrane surface antigen	-	-	-	-	-	-	-	-	-	-	-	-	17kDa_Anti_2,Rick_17kDa_Anti
k59_1659886_1	1123368.AUIS01000003_gene1618	9.6e-40	138.0	COG0625@1|root,COG0625@2|Bacteria,1MXJD@1224|Proteobacteria,1RP12@1236|Gammaproteobacteria,2NC81@225057|Acidithiobacillales	225057|Acidithiobacillales	O	Glutathione S-transferase, C-terminal domain	-	-	-	ko:K03599	-	-	-	-	ko00000,ko02000,ko03021	1.A.12.3.1	-	-	GST_C,GST_C_2,GST_N_3
k59_1659886_2	1101195.Meth11DRAFT_0352	1.55e-23	95.9	COG2969@1|root,COG2969@2|Bacteria,1MZ2Q@1224|Proteobacteria,2VSGG@28216|Betaproteobacteria,2KMYV@206350|Nitrosomonadales	206350|Nitrosomonadales	S	PFAM Stringent starvation protein B	-	-	-	ko:K03600	-	-	-	-	ko00000,ko03021	-	-	-	SspB
k59_1659886_3	194439.CT2219	3.74e-51	166.0	COG2110@1|root,COG2110@2|Bacteria	2|Bacteria	P	phosphatase homologous to the C-terminal domain of histone macroH2A1	ymdB	-	-	-	-	-	-	-	-	-	-	-	Macro
k59_104437_1	1502724.FF80_01249	2.3e-75	244.0	COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,2TRDD@28211|Alphaproteobacteria,3N64P@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
k59_1275693_1	1134413.ANNK01000001_gene2129	8.72e-40	149.0	COG0445@1|root,COG0445@2|Bacteria,1TQ4B@1239|Firmicutes,4HA6S@91061|Bacilli,1ZB67@1386|Bacillus	91061|Bacilli	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
k59_770526_2	321327.CYA_2594	6.86e-32	113.0	COG0759@1|root,COG0759@2|Bacteria,1G90B@1117|Cyanobacteria,1H14U@1129|Synechococcus	1117|Cyanobacteria	S	Could be involved in insertion of integral membrane proteins into the membrane	-	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
k59_995327_1	290315.Clim_1987	5.8e-24	99.4	COG0546@1|root,COG0546@2|Bacteria,1FDVN@1090|Chlorobi	1090|Chlorobi	S	PFAM Haloacid dehalogenase domain protein hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
k59_1548030_1	1173028.ANKO01000042_gene858	1.66e-50	181.0	COG2366@1|root,COG2366@2|Bacteria,1G4M5@1117|Cyanobacteria	1117|Cyanobacteria	S	penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
k59_1605884_1	1293047.CBMA010000021_gene1164	1.22e-42	155.0	COG0733@1|root,arCOG04466@2157|Archaea,2XUK4@28890|Euryarchaeota,23UHD@183963|Halobacteria	183963|Halobacteria	P	COG0733 Na -dependent transporters of the SNF family	-	-	-	ko:K03308	-	-	-	-	ko00000	2.A.22.4,2.A.22.5	-	-	SNF
k59_1275715_1	1206729.BAFZ01000061_gene3867	3.4e-20	88.6	COG1309@1|root,COG1309@2|Bacteria,2ICTB@201174|Actinobacteria,4FX8G@85025|Nocardiaceae	201174|Actinobacteria	K	WHG domain	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
k59_718522_2	1242864.D187_008956	4.25e-08	58.5	COG3225@1|root,COG3225@2|Bacteria,1MY63@1224|Proteobacteria,42N95@68525|delta/epsilon subdivisions,2WJ0N@28221|Deltaproteobacteria,2Z1WX@29|Myxococcales	28221|Deltaproteobacteria	N	ABC-type uncharacterized transport system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux
k59_212885_1	1380386.JIAW01000030_gene3590	2.49e-36	139.0	COG1178@1|root,COG1178@2|Bacteria,2GKDH@201174|Actinobacteria,2392Z@1762|Mycobacteriaceae	201174|Actinobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02011,ko:K02063	ko02010,map02010	M00190,M00191	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10,3.A.1.19	-	-	BPD_transp_1,SBP_bac_6
k59_1051339_1	572477.Alvin_0642	4.1e-26	112.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
k59_1106142_1	388399.SSE37_01065	8.91e-13	73.2	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_329352_1	1500259.JQLD01000010_gene4824	5.44e-15	77.4	COG3181@1|root,COG3181@2|Bacteria,1N3HN@1224|Proteobacteria,2UDSB@28211|Alphaproteobacteria,4BAAR@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_1216036_1	1051632.TPY_0730	9.14e-67	214.0	COG2896@1|root,COG2896@2|Bacteria,1TP89@1239|Firmicutes,247PP@186801|Clostridia,3WCYS@538999|Clostridiales incertae sedis	186801|Clostridia	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
k59_104489_1	870187.Thini_1508	5.78e-50	162.0	COG0328@1|root,COG0328@2|Bacteria,1RCZ1@1224|Proteobacteria,1S3YC@1236|Gammaproteobacteria,460RH@72273|Thiotrichales	72273|Thiotrichales	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhA	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_H
k59_104489_2	83406.HDN1F_16680	6.81e-22	90.9	COG0847@1|root,COG0847@2|Bacteria,1MV8Z@1224|Proteobacteria,1RNHQ@1236|Gammaproteobacteria,1J4T2@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease	dnaQ	GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016787,GO:0016788,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0045004,GO:0045005,GO:0046483,GO:0050896,GO:0051716,GO:0061695,GO:0071704,GO:0090304,GO:0090305,GO:1901360,GO:1901576,GO:1902494,GO:1990234	2.7.7.7,3.1.26.4	ko:K02342,ko:K14159	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_H,RNase_T
k59_1659944_1	1453500.AT05_01460	2.54e-51	169.0	COG0223@1|root,COG0223@2|Bacteria	2|Bacteria	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	-	GO:0003674,GO:0003824,GO:0004479,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009405,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0042802,GO:0042803,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044419,GO:0046483,GO:0046983,GO:0051704,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.1.2.2,2.1.2.9	ko:K00604,ko:K11175	ko00230,ko00670,ko00970,ko01100,ko01110,ko01130,map00230,map00670,map00970,map01100,map01110,map01130	M00048	R03940,R04325,R04326	RC00026,RC00165,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N
k59_548949_1	83406.HDN1F_23210	2.87e-81	251.0	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,1RNHY@1236|Gammaproteobacteria,1J4DE@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	GO:0006457,GO:0008150,GO:0009987	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
k59_718550_1	379066.GAU_2518	2.12e-11	65.1	COG4972@1|root,COG4972@2|Bacteria,1ZSYA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	NU	Type IV pilus assembly protein PilM;	-	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
k59_658080_1	1519464.HY22_08035	2.27e-42	149.0	COG3483@1|root,COG3483@2|Bacteria	2|Bacteria	E	tryptophan 2,3-dioxygenase activity	kynA	GO:0003674,GO:0003824,GO:0004833,GO:0005488,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016043,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0019439,GO:0019441,GO:0019752,GO:0020037,GO:0022607,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043436,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046906,GO:0048037,GO:0051213,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0070189,GO:0071704,GO:0071840,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.13.11.11,4.1.1.45	ko:K00453,ko:K03392	ko00380,ko01100,map00380,map01100	M00038	R00678,R04323	RC00356,RC00779	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_dioxygenase
k59_718560_1	1207063.P24_04060	2.07e-37	137.0	COG0730@1|root,COG0730@2|Bacteria,1NAFA@1224|Proteobacteria,2U1B5@28211|Alphaproteobacteria,2JT8C@204441|Rhodospirillales	204441|Rhodospirillales	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
k59_941503_1	1203568.HMPREF1484_01125	1.95e-51	171.0	COG0745@1|root,COG0745@2|Bacteria,2H3IN@201174|Actinobacteria,4FCH7@85020|Dermabacteraceae	201174|Actinobacteria	KT	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
k59_104510_1	1347392.CCEZ01000043_gene99	6.84e-41	149.0	COG1228@1|root,COG1228@2|Bacteria,1TQQ0@1239|Firmicutes,24EHA@186801|Clostridia,36DKU@31979|Clostridiaceae	186801|Clostridia	Q	Psort location Cytoplasmic, score 7.50	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_1496445_1	1121459.AQXE01000010_gene1959	3.89e-14	79.0	COG1729@1|root,COG1729@2|Bacteria,1MUSV@1224|Proteobacteria,42P32@68525|delta/epsilon subdivisions,2WM9Q@28221|Deltaproteobacteria,2MC83@213115|Desulfovibrionales	28221|Deltaproteobacteria	D	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division	cpoB	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6
k59_883503_1	1089453.GOSPT_117_00420	5.92e-69	233.0	COG0653@1|root,COG0653@2|Bacteria,2GIRT@201174|Actinobacteria,4GAIX@85026|Gordoniaceae	201174|Actinobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030312,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_1718006_1	396588.Tgr7_2927	1.26e-32	122.0	COG0603@1|root,COG0603@2|Bacteria,1NPKF@1224|Proteobacteria,1SQ05@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Queuosine biosynthesis protein QueC	-	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	QueC
k59_1332533_1	118173.KB235914_gene1075	2.74e-13	66.2	COG3631@1|root,COG3631@2|Bacteria,1GABI@1117|Cyanobacteria	1117|Cyanobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
k59_1332533_2	395495.Lcho_3159	5.69e-20	90.1	COG3509@1|root,COG3509@2|Bacteria,1NTIV@1224|Proteobacteria,2VKDX@28216|Betaproteobacteria,1KNPQ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	depolymerase	-	-	3.1.1.75	ko:K05973	ko00650,map00650	-	R05118	-	ko00000,ko00001,ko01000	-	-	-	Esterase_phd
k59_331601_1	240015.ACP_1902	1.59e-51	176.0	COG0774@1|root,COG0774@2|Bacteria,3Y40I@57723|Acidobacteria,2JI1R@204432|Acidobacteriia	204432|Acidobacteriia	M	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis	lpxC	-	3.5.1.108	ko:K02535	ko00540,ko01100,map00540,map01100	M00060	R04587	RC00166,RC00300	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxC
k59_1498412_1	2340.JV46_04470	2.98e-31	123.0	COG3850@1|root,COG3850@2|Bacteria,1MWZT@1224|Proteobacteria,1RNPP@1236|Gammaproteobacteria,1J7D0@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07673	ko02020,map02020	M00471	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	GAF_2,HAMP,HATPase_c,HisKA_3
k59_1498412_2	867903.ThesuDRAFT_01767	3.12e-14	73.6	COG0745@1|root,COG0745@2|Bacteria,1TS81@1239|Firmicutes,248XH@186801|Clostridia,3WD8H@538999|Clostridiales incertae sedis	186801|Clostridia	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K02483,ko:K07669	ko02020,map02020	M00460	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_1277825_1	69279.BG36_13175	5.48e-16	81.3	COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,2TT9G@28211|Alphaproteobacteria,43JWR@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	apbE	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
k59_384882_1	1410612.JNKO01000002_gene2271	1.8e-10	67.4	COG1197@1|root,COG1197@2|Bacteria,1TPF1@1239|Firmicutes,248D8@186801|Clostridia,2PRVR@265975|Oribacterium	186801|Clostridia	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_943520_1	1121918.ARWE01000001_gene1451	1.65e-24	106.0	COG0457@1|root,COG0457@2|Bacteria,1QXGV@1224|Proteobacteria,42RIF@68525|delta/epsilon subdivisions,2WNC6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
k59_943521_1	479431.Namu_1481	1.21e-18	84.7	COG0406@1|root,COG0494@1|root,COG0406@2|Bacteria,COG0494@2|Bacteria,2GNRV@201174|Actinobacteria,4EXC2@85013|Frankiales	201174|Actinobacteria	GL	NUDIX domain	mutT	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	His_Phos_1,NUDIX
k59_659787_1	1347393.HG726019_gene7712	1.39e-31	127.0	COG1629@1|root,COG1629@2|Bacteria,4NDXS@976|Bacteroidetes,2FKYX@200643|Bacteroidia,4AK5Y@815|Bacteroidaceae	976|Bacteroidetes	P	TonB-linked outer membrane protein, SusC RagA family	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Plug,STN,TonB_dep_Rec
k59_885714_1	913325.N799_09595	6.29e-57	194.0	COG2234@1|root,COG2234@2|Bacteria,1MV86@1224|Proteobacteria,1RNNQ@1236|Gammaproteobacteria,1X4D8@135614|Xanthomonadales	135614|Xanthomonadales	S	aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
k59_270857_1	1123368.AUIS01000024_gene948	2.57e-97	292.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria,2NCCI@225057|Acidithiobacillales	225057|Acidithiobacillales	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
k59_1607657_2	626887.J057_19575	1.37e-48	172.0	COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,1RMUH@1236|Gammaproteobacteria,464RK@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	COG1034 NADH dehydrogenase NADH ubiquinone oxidoreductase 75 kD subunit (chain G)	nuoG	GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009060,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0046034,GO:0046483,GO:0048037,GO:0050136,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0055086,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:0098797,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1990204	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iECs_1301.ECs3167,iG2583_1286.G2583_2820,iZ_1308.Z3542	Fer2_4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_1661531_1	713586.KB900536_gene3074	6.93e-34	124.0	2E55J@1|root,32ZYF@2|Bacteria,1N9FR@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1277872_1	1238182.C882_1234	2.48e-123	370.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,2TU21@28211|Alphaproteobacteria,2JSY5@204441|Rhodospirillales	204441|Rhodospirillales	C	Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR,POR_N
k59_214497_1	394.NGR_c16990	1.53e-15	75.9	COG3200@1|root,COG3200@2|Bacteria,1MUWF@1224|Proteobacteria,2TR0E@28211|Alphaproteobacteria,4B74G@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	phospho-2-dehydro-3-deoxyheptonate aldolase	aroF	GO:0003674,GO:0003824,GO:0003849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009507,GO:0009536,GO:0009611,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019438,GO:0019752,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0050896,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_2
k59_214497_2	1469245.JFBG01000044_gene1864	4.07e-20	87.8	COG0846@1|root,COG0846@2|Bacteria,1MUK1@1224|Proteobacteria,1RMX5@1236|Gammaproteobacteria,1WYE1@135613|Chromatiales	135613|Chromatiales	K	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form	cobB	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
k59_1217558_1	795359.TOPB45_1518	5.77e-12	65.5	COG0182@1|root,COG0182@2|Bacteria,2GH81@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
k59_1217558_2	926569.ANT_16180	7.39e-62	199.0	COG0524@1|root,COG0524@2|Bacteria,2G7YR@200795|Chloroflexi	200795|Chloroflexi	G	PFAM PfkB domain protein	adoK	-	2.7.1.20	ko:K00856	ko00230,ko01100,map00230,map01100	-	R00185	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
k59_659829_1	716928.AJQT01000039_gene1476	9.04e-38	137.0	COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,2TTI9@28211|Alphaproteobacteria,4BCG0@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_659829_2	1444306.JFZC01000033_gene2564	1.35e-14	73.6	COG0495@1|root,COG0495@2|Bacteria,1TP0Y@1239|Firmicutes,4HAG1@91061|Bacilli,26NMV@186821|Sporolactobacillaceae	91061|Bacilli	J	Leucyl-tRNA synthetase, Domain 2	leuS	GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
k59_1165160_1	1144275.COCOR_07525	1.23e-14	76.6	COG4221@1|root,COG4221@2|Bacteria,1MUF8@1224|Proteobacteria,42KZX@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	cad	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_659834_1	1462527.CCDM010000008_gene214	5.59e-09	61.2	COG0697@1|root,COG0697@2|Bacteria,1V230@1239|Firmicutes,4HPYF@91061|Bacilli	91061|Bacilli	EG	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA,Multi_Drug_Res
k59_1549688_1	667014.Thein_0671	2e-41	151.0	COG2204@1|root,COG2204@2|Bacteria,2GH79@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	T	Two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_885786_1	767817.Desgi_0419	1.66e-84	274.0	COG1529@1|root,COG1529@2|Bacteria,1TP7U@1239|Firmicutes,248BV@186801|Clostridia	186801|Clostridia	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_996741_1	926550.CLDAP_25010	5.79e-71	233.0	COG0365@1|root,COG0365@2|Bacteria,2G830@200795|Chloroflexi	200795|Chloroflexi	I	Acetyl-coenzyme A synthetase N-terminus	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_1217584_1	626887.J057_16175	7.92e-18	85.9	COG2755@1|root,COG2755@2|Bacteria,1MXBN@1224|Proteobacteria,1RQJF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	GDSL-like Lipase/Acylhydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
k59_112983_2	671143.DAMO_1587	3.21e-18	81.6	COG0526@1|root,COG0526@2|Bacteria,2NPYK@2323|unclassified Bacteria	2|Bacteria	O	Thioredoxin-like	dsbE	-	-	ko:K02199,ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	AhpC-TSA,Redoxin,Thioredoxin
k59_1002559_1	1123514.KB905899_gene842	4.39e-87	280.0	COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,1RN49@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	COG0577 ABC-type antimicrobial peptide transport system permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_1613984_1	882083.SacmaDRAFT_1924	5.1e-53	174.0	2DPCA@1|root,331H2@2|Bacteria,2HCYY@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_335336_2	234267.Acid_6848	3.11e-21	93.2	COG0028@1|root,COG0028@2|Bacteria	2|Bacteria	EH	Belongs to the TPP enzyme family	mdlC	-	2.2.1.6,4.1.1.7	ko:K01576,ko:K01652	ko00290,ko00627,ko00650,ko00660,ko00770,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00290,map00627,map00650,map00660,map00770,map01100,map01110,map01120,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R01764,R02672,R03050,R04672,R04673,R08648	RC00027,RC00106,RC00595,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_669007_1	1267533.KB906733_gene3430	6.52e-48	159.0	COG0669@1|root,COG0669@2|Bacteria,3Y4B6@57723|Acidobacteria,2JJ6A@204432|Acidobacteriia	204432|Acidobacteriia	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
k59_669007_2	398767.Glov_1768	1.13e-64	211.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,42MKR@68525|delta/epsilon subdivisions,2WIS3@28221|Deltaproteobacteria,43TQ7@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	PFAM aminotransferase, class I and II	aspB	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_1169324_1	1461580.CCAS010000003_gene501	4.44e-06	53.1	COG1388@1|root,COG2340@1|root,COG1388@2|Bacteria,COG2340@2|Bacteria,1V6GZ@1239|Firmicutes,4HDFU@91061|Bacilli,1ZPV1@1386|Bacillus	91061|Bacilli	M	Cysteine-rich secretory protein family	-	-	-	-	-	-	-	-	-	-	-	-	CAP,LysM
k59_502189_1	234267.Acid_7645	1.06e-90	278.0	COG0517@1|root,COG0517@2|Bacteria,3Y7MI@57723|Acidobacteria	57723|Acidobacteria	S	Putative transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
k59_168634_1	1120950.KB892739_gene3990	6.34e-32	117.0	COG0346@1|root,COG0346@2|Bacteria,2IPGW@201174|Actinobacteria	201174|Actinobacteria	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase
k59_613338_1	1150398.JIBJ01000004_gene2908	2.48e-77	258.0	COG3696@1|root,COG3696@2|Bacteria,2I53X@201174|Actinobacteria,1WCG2@1268|Micrococcaceae	201174|Actinobacteria	P	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1002582_1	926569.ANT_01840	3.59e-85	262.0	COG0205@1|root,COG0205@2|Bacteria,2G62R@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfkA	-	2.7.1.11	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
k59_1336124_2	570952.ATVH01000015_gene1505	1.76e-27	109.0	COG1960@1|root,COG1960@2|Bacteria,1MX17@1224|Proteobacteria,2TTRE@28211|Alphaproteobacteria,2JRJN@204441|Rhodospirillales	204441|Rhodospirillales	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_1939_1	1101191.KI912577_gene307	8.6e-18	83.6	COG4232@1|root,COG4233@1|root,COG4232@2|Bacteria,COG4233@2|Bacteria,1MU8W@1224|Proteobacteria,2TTUM@28211|Alphaproteobacteria,1JSKK@119045|Methylobacteriaceae	28211|Alphaproteobacteria	CO	Disulphide bond corrector protein DsbC	dsbD	-	1.8.1.8	ko:K04084	-	-	-	-	ko00000,ko01000,ko03110	5.A.1.1	-	-	DsbC,DsbD,Thioredoxin_7
k59_1939_2	1054213.HMPREF9946_04566	1.73e-21	90.9	COG1225@1|root,COG1225@2|Bacteria,1RD2X@1224|Proteobacteria,2U7PM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	COG0526 Thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
k59_1391555_1	759914.BP951000_1928	4.33e-10	68.6	COG1674@1|root,COG1674@2|Bacteria,2J63D@203691|Spirochaetes	203691|Spirochaetes	D	Belongs to the FtsK SpoIIIE SftA family	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
k59_1391555_3	240016.ABIZ01000001_gene3699	5.63e-21	94.0	COG0847@1|root,COG0847@2|Bacteria	2|Bacteria	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease	-	-	-	-	-	-	-	-	-	-	-	-	RNase_T
k59_1391555_8	767817.Desgi_4403	1.17e-32	120.0	COG3747@1|root,COG3747@2|Bacteria,1V0EC@1239|Firmicutes,24GCB@186801|Clostridia	186801|Clostridia	L	phage terminase, small subunit	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_4
k59_1391555_9	1123269.NX02_29280	1.31e-87	290.0	COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria,2TTEX@28211|Alphaproteobacteria,2K385@204457|Sphingomonadales	204457|Sphingomonadales	S	Phage Terminase	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_1
k59_1391555_13	466088.CL42_02065	1.75e-94	287.0	COG0270@1|root,COG0270@2|Bacteria,1N0XD@1224|Proteobacteria,1T05A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	C-5 cytosine-specific DNA methylase	-	-	-	-	-	-	-	-	-	-	-	-	DNA_methylase
k59_1391555_14	1244869.H261_13384	3.31e-35	124.0	2CRRJ@1|root,32SPH@2|Bacteria,1NYMT@1224|Proteobacteria,2UTVD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3307)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3307
k59_1391555_16	1408311.JNJM01000048_gene89	3.49e-21	89.7	COG1611@1|root,COG1611@2|Bacteria,1V7HV@1239|Firmicutes,24JN5@186801|Clostridia,2PTJ9@265975|Oribacterium	186801|Clostridia	S	Belongs to the LOG family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1391555_19	1408422.JHYF01000021_gene982	3.39e-81	263.0	COG4695@1|root,COG4695@2|Bacteria,1TP8B@1239|Firmicutes,2497C@186801|Clostridia,36H1A@31979|Clostridiaceae	186801|Clostridia	S	Phage portal protein, HK97 family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_portal
k59_1391555_20	311402.Avi_1969	5.85e-41	145.0	COG3740@1|root,COG3740@2|Bacteria,1NHKT@1224|Proteobacteria,2U82W@28211|Alphaproteobacteria,4BDKN@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Caudovirus prohead serine protease	-	-	-	ko:K06904	-	-	-	-	ko00000	-	-	-	Peptidase_S78
k59_1391555_21	1125863.JAFN01000001_gene3549	3.3e-41	165.0	COG4653@1|root,COG4653@2|Bacteria,1MWMB@1224|Proteobacteria,42UPY@68525|delta/epsilon subdivisions,2WQZZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Phage capsid family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_capsid
k59_1391555_30	646529.Desaci_1303	3.34e-20	91.3	2CK39@1|root,32SBG@2|Bacteria,1V8KG@1239|Firmicutes	1239|Firmicutes	S	Phage gp6-like head-tail connector protein	-	-	-	-	-	-	-	-	-	-	-	-	Phage_connect_1
k59_1391555_31	794903.OPIT5_19655	1.75e-32	119.0	COG0629@1|root,COG0629@2|Bacteria,46VZR@74201|Verrucomicrobia,3K80H@414999|Opitutae	414999|Opitutae	L	Single-stranded DNA-binding protein	-	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
k59_1391555_32	1220582.RRU01S_15_00630	2.11e-13	68.2	COG5614@1|root,COG5614@2|Bacteria,1N7DY@1224|Proteobacteria,2UGEF@28211|Alphaproteobacteria,4BFEV@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Head-tail adaptor	-	-	-	-	-	-	-	-	-	-	-	-	Phage_H_T_join
k59_1391555_38	443152.MDG893_20559	1.4e-42	168.0	COG2911@1|root,COG2911@2|Bacteria,1QU6S@1224|Proteobacteria,1S7WY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	D	tail tape measure protein	-	-	-	-	-	-	-	-	-	-	-	-	SLT,Tape_meas_lam_C
k59_1391555_53	1441930.Z042_22925	7.74e-39	140.0	2CWYZ@1|root,32T0P@2|Bacteria,1MZEM@1224|Proteobacteria,1S9HP@1236|Gammaproteobacteria,4057M@613|Serratia	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_113036_1	388739.RSK20926_18162	3.16e-05	45.8	COG0599@1|root,COG0599@2|Bacteria,1MZ80@1224|Proteobacteria,2UDE8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
k59_113036_2	59538.XP_005973164.1	1.73e-51	169.0	COG1028@1|root,KOG0725@2759|Eukaryota,39N8C@33154|Opisthokonta,3CPTA@33208|Metazoa,3E5YA@33213|Bilateria,48SPG@7711|Chordata,49P76@7742|Vertebrata	33208|Metazoa	Q	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_1391566_1	1144275.COCOR_00333	3.89e-17	86.3	COG1080@1|root,COG1925@1|root,COG4668@1|root,COG1080@2|Bacteria,COG1925@2|Bacteria,COG4668@2|Bacteria,1MUT8@1224|Proteobacteria,42P77@68525|delta/epsilon subdivisions,2WJ6F@28221|Deltaproteobacteria,2YU1Z@29|Myxococcales	28221|Deltaproteobacteria	G	PTS HPr component phosphorylation site	-	-	2.7.1.202,2.7.3.9	ko:K02768,ko:K08483,ko:K11183	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1,8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C,PTS-HPr,PTS_EIIA_2
k59_1058132_1	1121033.AUCF01000004_gene4772	3.15e-44	158.0	COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,2TSGV@28211|Alphaproteobacteria,2JPP4@204441|Rhodospirillales	204441|Rhodospirillales	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	cheB	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
k59_613369_1	1366050.N234_01075	1.68e-53	175.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2VMEE@28216|Betaproteobacteria	28216|Betaproteobacteria	E	ABC-type branched-chain amino acid transport systems ATPase component	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
k59_613369_2	1089552.KI911559_gene2274	2.29e-20	89.0	COG4177@1|root,COG4177@2|Bacteria,1NPII@1224|Proteobacteria,2TVFT@28211|Alphaproteobacteria,2JTIS@204441|Rhodospirillales	204441|Rhodospirillales	E	Branched-chain amino acid transport system / permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
k59_1558522_1	1333998.M2A_2719	3.85e-81	256.0	COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria,2TR5C@28211|Alphaproteobacteria,4BRV7@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	PFAM Membrane dipeptidase (Peptidase family M19)	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
k59_1058137_1	1064535.MELS_0888	2.24e-47	174.0	COG0280@1|root,COG4624@1|root,COG0280@2|Bacteria,COG4624@2|Bacteria,1TP6C@1239|Firmicutes,4H23R@909932|Negativicutes	909932|Negativicutes	C	hydrogenase, Fe-only	-	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fe_hyd_SSU,Fe_hyd_lg_C,Fer4,Fer4_10,PTA_PTB
k59_335383_1	246194.CHY_1731	1.16e-59	201.0	COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,248JC@186801|Clostridia,42FN9@68295|Thermoanaerobacterales	186801|Clostridia	IQ	PFAM AMP-dependent synthetase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
k59_113059_2	1254432.SCE1572_33175	0.00017	47.8	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,42M2A@68525|delta/epsilon subdivisions,2WJ41@28221|Deltaproteobacteria,2YUJJ@29|Myxococcales	28221|Deltaproteobacteria	S	ABC transporter, ATP-binding protein	ybiT	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
k59_1447461_1	1313172.YM304_32120	9.26e-47	170.0	COG0477@1|root,COG0477@2|Bacteria,2GIUM@201174|Actinobacteria,4CNFR@84992|Acidimicrobiia	84992|Acidimicrobiia	U	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1391597_1	1056820.KB900638_gene112	1.44e-14	73.2	COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,1RR0T@1236|Gammaproteobacteria,2PPXR@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	L	Transposase DDE domain	insH6	GO:0000271,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004803,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006139,GO:0006259,GO:0006310,GO:0006313,GO:0006351,GO:0006355,GO:0006629,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009279,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016051,GO:0016070,GO:0016740,GO:0016757,GO:0016758,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019867,GO:0030312,GO:0030313,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031975,GO:0032196,GO:0032774,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044424,GO:0044444,GO:0044462,GO:0044464,GO:0045226,GO:0045893,GO:0045935,GO:0046379,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140097,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1903509,GO:2000112,GO:2001141	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
k59_724777_1	309801.trd_A0591	8.29e-61	199.0	COG4948@1|root,COG4948@2|Bacteria,2G69R@200795|Chloroflexi,27YSG@189775|Thermomicrobia	189775|Thermomicrobia	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	4.2.1.6	ko:K01684	ko00052,ko01100,ko01120,map00052,map01100,map01120	M00552	R03033	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
k59_669120_1	1380394.JADL01000003_gene5097	2.37e-23	102.0	COG1566@1|root,COG1566@2|Bacteria,1RJ6W@1224|Proteobacteria,2TWAT@28211|Alphaproteobacteria,2JZ3S@204441|Rhodospirillales	204441|Rhodospirillales	V	HlyD family secretion protein	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_3
k59_613431_1	331869.BAL199_10657	0.000124	43.5	COG0664@1|root,COG0664@2|Bacteria,1RI6M@1224|Proteobacteria,2U9WH@28211|Alphaproteobacteria,4BQJM@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	K	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
k59_613431_2	1089551.KE386572_gene1598	3.37e-19	89.7	COG1132@1|root,COG1132@2|Bacteria,1MWTY@1224|Proteobacteria,2TRSY@28211|Alphaproteobacteria,4BP58@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	V	ABC transporter transmembrane region	-	-	-	ko:K02021	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21	-	-	ABC_membrane,ABC_tran,cNMP_binding
k59_1725326_1	1071073.KI530534_gene779	4.4e-16	75.5	COG0360@1|root,COG0360@2|Bacteria,1VA18@1239|Firmicutes,4HKHD@91061|Bacilli,1ZGZ0@1386|Bacillus	91061|Bacilli	J	Binds together with S18 to 16S ribosomal RNA	rpsF	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0097159,GO:1901363,GO:1990904	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
k59_1627943_1	1122222.AXWR01000021_gene2301	1.1e-22	102.0	COG2203@1|root,COG3437@1|root,COG2203@2|Bacteria,COG3437@2|Bacteria,1WJ00@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	Metal dependent phosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HD,HD_5,PAS_3,PAS_4,PAS_8
k59_182721_1	1123267.JONN01000001_gene417	1.94e-22	97.1	2EYIJ@1|root,33RSC@2|Bacteria,1NQWX@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1406335_1	402777.KB235904_gene4743	4.09e-107	331.0	COG3957@1|root,COG3957@2|Bacteria,1G0B2@1117|Cyanobacteria,1H7CT@1150|Oscillatoriales	1117|Cyanobacteria	G	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase	-	-	4.1.2.22,4.1.2.9	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120	-	R00761,R01621	RC00032,RC00226	ko00000,ko00001,ko01000	-	-	-	XFP,XFP_C,XFP_N
k59_1572998_2	985255.APHJ01000026_gene2357	8.13e-19	79.0	COG0607@1|root,30IQR@2|Bacteria,4NVMW@976|Bacteroidetes,1I52X@117743|Flavobacteriia	976|Bacteroidetes	P	Protein of unknown function (DUF2892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
k59_1739680_1	710685.MycrhN_4597	1.07e-06	51.2	COG3707@1|root,COG3707@2|Bacteria,2GK7T@201174|Actinobacteria,235QN@1762|Mycobacteriaceae	201174|Actinobacteria	T	response regulator	pdtaR	GO:0000160,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0016020,GO:0023052,GO:0030312,GO:0035556,GO:0040007,GO:0043167,GO:0043168,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071944	-	ko:K22010	-	M00839	-	-	ko00000,ko00002,ko02022	-	-	-	ANTAR,Response_reg
k59_1739680_2	646529.Desaci_2639	3.32e-13	68.6	COG2197@1|root,COG2197@2|Bacteria,1TQ1U@1239|Firmicutes,24IAA@186801|Clostridia	186801|Clostridia	K	PFAM Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_1684144_1	1304878.AUGD01000050_gene3130	3.71e-52	164.0	COG2963@1|root,COG2963@2|Bacteria,1MZ3D@1224|Proteobacteria,2UBSS@28211|Alphaproteobacteria,3K65N@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Transposase	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_1684144_2	1304878.AUGD01000014_gene2984	3.49e-52	170.0	COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,3JURJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Integrase core domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
k59_1739682_2	1123073.KB899241_gene2709	6.23e-39	137.0	COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,1RMWT@1236|Gammaproteobacteria,1X2XT@135614|Xanthomonadales	135614|Xanthomonadales	KT	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	phoP	-	-	ko:K07660	ko01503,ko02020,map01503,map02020	M00444,M00709,M00721,M00723,M00724,M00744	-	-	ko00000,ko00001,ko00002,ko01504,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_1406349_1	1207063.P24_00730	3.64e-64	206.0	COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,2TR0J@28211|Alphaproteobacteria,2JQ5Z@204441|Rhodospirillales	204441|Rhodospirillales	EP	COG0444 ABC-type dipeptide oligopeptide nickel transport system, ATPase component	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_1406349_2	1502851.FG93_04061	1.08e-50	169.0	COG1173@1|root,COG1173@2|Bacteria,1MXGS@1224|Proteobacteria,2TTQ7@28211|Alphaproteobacteria,3JWG9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EP	N-terminal TM domain of oligopeptide transport permease C	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
k59_571847_1	1144275.COCOR_05386	1.27e-106	328.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIVD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NU	General secretory system II, protein E domain protein	pulE-3	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
k59_961528_1	319003.Bra1253DRAFT_07121	5.09e-65	214.0	COG2114@1|root,COG2267@1|root,COG2114@2|Bacteria,COG2267@2|Bacteria,1QXEH@1224|Proteobacteria,2TX96@28211|Alphaproteobacteria,3K6W1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IT	Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,FHA,Guanylate_cyc
k59_794947_1	404589.Anae109_1010	3.9e-45	159.0	COG0427@1|root,COG0427@2|Bacteria,1MUGE@1224|Proteobacteria,42MHC@68525|delta/epsilon subdivisions,2WINZ@28221|Deltaproteobacteria,2YW0C@29|Myxococcales	28221|Deltaproteobacteria	C	Acetyl-CoA hydrolase/transferase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro,Acetyltransf_1
k59_1072512_1	450851.PHZ_c3077	6.26e-05	51.6	28NHI@1|root,2ZBJA@2|Bacteria,1RCPZ@1224|Proteobacteria,2UKQP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_849633_1	316067.Geob_0473	6.18e-05	44.7	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,42KZE@68525|delta/epsilon subdivisions,2WIPT@28221|Deltaproteobacteria,43TW3@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein	nuoL-1	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_C,Proton_antipo_M,Proton_antipo_N
k59_849633_2	1211814.CAPG01000062_gene2977	3.25e-25	97.4	COG0713@1|root,COG0713@2|Bacteria,1V9Z8@1239|Firmicutes,4HJ9Q@91061|Bacilli,1ZGXH@1386|Bacillus	91061|Bacilli	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
k59_126856_1	930169.B5T_01426	6.95e-83	255.0	COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,1SY09@1236|Gammaproteobacteria,1XQ9J@135619|Oceanospirillales	135619|Oceanospirillales	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_1573033_1	395493.BegalDRAFT_2504	6.69e-99	299.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RM93@1236|Gammaproteobacteria,461J8@72273|Thiotrichales	72273|Thiotrichales	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_1350597_1	292564.Cyagr_0688	9.07e-13	73.9	COG0793@1|root,COG0793@2|Bacteria,1G1YJ@1117|Cyanobacteria,22S6K@167375|Cyanobium	1117|Cyanobacteria	M	Belongs to the peptidase S41A family	prc	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_S41,Tricorn_C1
k59_1462142_1	1120792.JAFV01000001_gene184	3.91e-45	153.0	2BKYI@1|root,32FF5@2|Bacteria,1MY1A@1224|Proteobacteria,2U1KI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctB family	-	-	-	-	-	-	-	-	-	-	-	-	TctB
k59_1517366_1	1122613.ATUP01000001_gene2128	7.81e-12	66.2	COG2121@1|root,COG2121@2|Bacteria,1MZID@1224|Proteobacteria,2TSGQ@28211|Alphaproteobacteria,43XS3@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	protein conserved in bacteria	MA20_05800	-	-	ko:K09778	-	-	-	-	ko00000	-	-	-	DUF374
k59_1517366_2	402881.Plav_0625	7.39e-21	92.4	COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,2TS37@28211|Alphaproteobacteria,1JNCG@119043|Rhodobiaceae	28211|Alphaproteobacteria	M	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase)	kdtA	-	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30	-	Glycos_transf_N
k59_71892_1	553204.CORAM0001_0340	2.75e-79	251.0	COG1740@1|root,COG1740@2|Bacteria,2GKF2@201174|Actinobacteria,22KF9@1653|Corynebacteriaceae	201174|Actinobacteria	C	small subunit	hoxK	-	1.12.99.6	ko:K06282	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFe_hyd_SSU_C,Oxidored_q6
k59_239046_1	1220534.B655_1695	1.71e-60	204.0	COG2055@1|root,arCOG04874@2157|Archaea,2XVBT@28890|Euryarchaeota,23PEF@183925|Methanobacteria	183925|Methanobacteria	C	Malate L-lactate dehydrogenase	comC	-	1.1.1.337	ko:K05884	ko00680,map00680	M00358	R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_2
k59_571911_1	1120972.AUMH01000001_gene1244	2.08e-81	261.0	COG0481@1|root,COG0481@2|Bacteria,1TP0G@1239|Firmicutes,4HASA@91061|Bacilli,2788E@186823|Alicyclobacillaceae	91061|Bacilli	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C
k59_849687_1	357808.RoseRS_3246	2.88e-91	285.0	COG0443@1|root,COG0443@2|Bacteria,2G5U5@200795|Chloroflexi,37538@32061|Chloroflexia	32061|Chloroflexia	O	Heat shock 70 kDa protein	-	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
k59_1406414_1	999423.HMPREF9161_01490	4.06e-18	82.4	COG0084@1|root,COG0084@2|Bacteria,1TNY1@1239|Firmicutes,4H2S5@909932|Negativicutes	909932|Negativicutes	L	hydrolase, TatD family	ycfH	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
k59_1406414_2	351160.RCIX291	1.24e-21	92.0	COG1392@1|root,arCOG02640@2157|Archaea,2XY03@28890|Euryarchaeota,2N9PU@224756|Methanomicrobia	224756|Methanomicrobia	P	Belongs to the Protein of	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
k59_16702_1	1203554.HMPREF1476_00285	3.59e-97	295.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,2VHYE@28216|Betaproteobacteria,4PQT9@995019|Sutterellaceae	28216|Betaproteobacteria	E	Glutamine synthetase, catalytic domain	glnA	GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016866,GO:0034022,GO:0042537,GO:0044237,GO:0050486,GO:0071704,GO:1901360	5.4.4.3,6.3.1.2	ko:K01915,ko:K20712	ko00220,ko00250,ko00627,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00627,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253,R06988,R09284	RC00010,RC01754,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
k59_1129055_1	443144.GM21_0435	4.91e-64	219.0	COG1361@1|root,COG3210@1|root,COG4932@1|root,COG1361@2|Bacteria,COG3210@2|Bacteria,COG4932@2|Bacteria,1R5G4@1224|Proteobacteria,42T0V@68525|delta/epsilon subdivisions,2WPRT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	TIGRFAM conserved repeat domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,SdrD_B
k59_1294811_1	574966.KB898652_gene1839	1.27e-07	55.5	COG1186@1|root,COG1186@2|Bacteria,1MUAW@1224|Proteobacteria,1RP9Z@1236|Gammaproteobacteria,1XHPA@135619|Oceanospirillales	135619|Oceanospirillales	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
k59_1294811_2	926569.ANT_16640	2.85e-42	146.0	COG0552@1|root,COG0552@2|Bacteria,2G63M@200795|Chloroflexi	200795|Chloroflexi	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
k59_1183968_1	1487953.JMKF01000002_gene523	5.28e-05	45.4	COG0665@1|root,COG0665@2|Bacteria,1G9ET@1117|Cyanobacteria	1117|Cyanobacteria	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
k59_1183968_2	412597.AEPN01000004_gene3200	1.98e-06	53.1	COG0665@1|root,COG0665@2|Bacteria,1MVM6@1224|Proteobacteria,2TRM7@28211|Alphaproteobacteria,2PU4G@265|Paracoccus	28211|Alphaproteobacteria	E	FAD dependent oxidoreductase	soxB3	-	1.5.3.1	ko:K00303	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO
k59_961623_1	326427.Cagg_1542	1.38e-106	317.0	COG0451@1|root,COG0451@2|Bacteria,2G7M6@200795|Chloroflexi	200795|Chloroflexi	GM	Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction	fcl	-	1.1.1.271	ko:K02377	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R05692	RC01014	ko00000,ko00001,ko01000	-	-	-	Epimerase
k59_906678_1	990285.RGCCGE502_01896	2.23e-37	141.0	COG0624@1|root,COG0624@2|Bacteria,1MVUX@1224|Proteobacteria,2TR5X@28211|Alphaproteobacteria,4B7CI@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia	amaB	-	3.5.1.6,3.5.1.87	ko:K06016	ko00240,ko01100,map00240,map01100	M00046	R00905,R04666	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
k59_1517410_1	671143.DAMO_1510	2.21e-16	73.2	COG0607@1|root,COG0607@2|Bacteria,2NRI8@2323|unclassified Bacteria	2|Bacteria	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_1517410_2	671143.DAMO_1612	5.71e-81	249.0	COG0492@1|root,COG0492@2|Bacteria,2NNS7@2323|unclassified Bacteria	2|Bacteria	O	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	GO:0000166,GO:0001666,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019725,GO:0036094,GO:0036293,GO:0040007,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070402,GO:0070482,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748	1.8.1.9,4.3.1.9	ko:K00384,ko:K03671,ko:K22345	ko00030,ko00450,ko04621,ko05418,map00030,map00450,map04621,map05418	-	R01544,R02016,R03596,R09372	RC00013,RC00544,RC02518,RC02873	ko00000,ko00001,ko01000,ko03110	-	-	iNJ661.Rv3913,iPC815.YPO1374	Pyr_redox_2
k59_849724_1	13349.G1WYQ2	7.31e-06	50.8	COG1785@1|root,KOG4126@2759|Eukaryota,38GD6@33154|Opisthokonta,3NUPA@4751|Fungi,3QNMU@4890|Ascomycota	4751|Fungi	P	alkaline phosphatase	PHO8	GO:0000322,GO:0000323,GO:0000324,GO:0000329,GO:0003674,GO:0003824,GO:0004035,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005773,GO:0005774,GO:0006139,GO:0006464,GO:0006470,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009987,GO:0016020,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019362,GO:0019538,GO:0019637,GO:0031090,GO:0034641,GO:0036211,GO:0042578,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0044422,GO:0044424,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:0098588,GO:0098805,GO:0098852,GO:1901360,GO:1901564	3.1.3.1	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	Alk_phosphatase
k59_849724_2	1449347.JQLN01000005_gene5308	4.48e-09	58.5	COG1171@1|root,COG1171@2|Bacteria,2GJAG@201174|Actinobacteria,2M25E@2063|Kitasatospora	201174|Actinobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_1241090_2	911045.PSE_0256	1.96e-47	164.0	COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,2TR4H@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	argininosuccinate lyase	argH	GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
k59_739602_1	1229780.BN381_210097	2.03e-89	290.0	COG2609@1|root,COG2609@2|Bacteria,2GJRE@201174|Actinobacteria,3UW8H@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	aceE	GO:0000287,GO:0003674,GO:0003824,GO:0004738,GO:0004739,GO:0005488,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016624,GO:0016903,GO:0030312,GO:0032991,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0045254,GO:0046872,GO:0055114,GO:0071944,GO:1902494,GO:1990204	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
k59_906724_1	314230.DSM3645_08942	5.07e-75	243.0	COG0405@1|root,COG0405@2|Bacteria,2IWWP@203682|Planctomycetes	203682|Planctomycetes	E	gamma-glutamyltransferase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k59_1294853_1	477641.MODMU_4429	2.91e-52	180.0	COG0004@1|root,COG0004@2|Bacteria,2GIZK@201174|Actinobacteria,4ERCB@85013|Frankiales	201174|Actinobacteria	P	Ammonium Transporter	amtB	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	iNJ661.Rv2920c	Ammonium_transp
k59_182878_1	682795.AciX8_2865	5.19e-22	100.0	COG0457@1|root,COG0515@1|root,COG1196@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG1196@2|Bacteria,3Y4IC@57723|Acidobacteria,2JJ7M@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
k59_126949_1	1382356.JQMP01000001_gene805	2.92e-61	207.0	COG0146@1|root,COG0146@2|Bacteria,2G644@200795|Chloroflexi,27XUU@189775|Thermomicrobia	189775|Thermomicrobia	EQ	PFAM Hydantoinase B oxoprolinase	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
k59_1739826_1	1449065.JMLL01000016_gene3024	1.44e-49	180.0	2DB7D@1|root,2Z7KR@2|Bacteria,1Q0FB@1224|Proteobacteria,2V1V2@28211|Alphaproteobacteria,43Q56@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1184020_1	485913.Krac_3007	2.99e-61	204.0	COG3464@1|root,COG3464@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	UPF0236
k59_739626_1	396595.TK90_0224	9.45e-15	69.3	COG3093@1|root,COG3093@2|Bacteria,1N76J@1224|Proteobacteria,1SCYV@1236|Gammaproteobacteria,1WYTT@135613|Chromatiales	135613|Chromatiales	K	TIGRFAM Addiction module antidote protein, HigA	-	-	-	ko:K21498	-	-	-	-	ko00000,ko02048	-	-	-	HTH_3
k59_684462_1	1071679.BG57_10455	8.41e-10	64.7	COG0745@1|root,COG5002@1|root,COG0745@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2VJ3Z@28216|Betaproteobacteria,1KIFW@119060|Burkholderiaceae	28216|Betaproteobacteria	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_9,Response_reg
k59_684465_1	1125973.JNLC01000001_gene89	1.41e-55	183.0	COG1305@1|root,COG1305@2|Bacteria,1MVAG@1224|Proteobacteria,2TSVH@28211|Alphaproteobacteria,3JU4J@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,Transglut_core
k59_906755_1	465515.Mlut_08500	2.42e-66	219.0	COG0129@1|root,COG0129@2|Bacteria,2GJIJ@201174|Actinobacteria,1W886@1268|Micrococcaceae	201174|Actinobacteria	E	Belongs to the IlvD Edd family	ilvD	GO:0003674,GO:0003824,GO:0004160,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
k59_1517455_1	518766.Rmar_1427	1.66e-83	266.0	COG0365@1|root,COG0365@2|Bacteria,4NEAD@976|Bacteroidetes,1FIMS@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	I	AMP-binding enzyme C-terminal domain	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_1350763_1	744980.TRICHSKD4_0980	8.56e-83	255.0	COG0834@1|root,COG0834@2|Bacteria,1MV5D@1224|Proteobacteria,2TSRF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	ET	COG0834 ABC-type amino acid transport signal transduction systems periplasmic component domain	aapJ	GO:0005575,GO:0005623,GO:0042597,GO:0044464	-	ko:K09969	ko02010,map02010	M00232	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	SBP_bac_3
k59_1241156_1	1536773.R70331_20380	3.85e-27	112.0	COG0337@1|root,COG0337@2|Bacteria,1TPKZ@1239|Firmicutes,4HAKN@91061|Bacilli,26RN4@186822|Paenibacillaceae	91061|Bacilli	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	4.2.3.4	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03083	RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
k59_961738_2	861299.J421_2380	3.28e-23	95.1	COG1595@1|root,COG1595@2|Bacteria,1ZSWF@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_1241182_1	1532558.JL39_03660	5.35e-10	63.2	COG1840@1|root,COG1840@2|Bacteria,1PDYC@1224|Proteobacteria,2TSWW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_1,SBP_bac_11,SBP_bac_6
k59_1462285_1	1189619.pgond44_14073	1.49e-62	217.0	COG0642@1|root,COG4191@1|root,COG2205@2|Bacteria,COG4191@2|Bacteria,4NEJX@976|Bacteroidetes,1I0JH@117743|Flavobacteriia	976|Bacteroidetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,HATPase_c,HisKA,TPR_12,TPR_7
k59_1129218_1	1194165.CAJF01000008_gene436	2.75e-82	257.0	COG4671@1|root,COG4671@2|Bacteria,2HT2Y@201174|Actinobacteria,4FRDV@85023|Microbacteriaceae	201174|Actinobacteria	I	Glycosyltransferase family 28 C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tran_28_C
k59_1294915_1	180332.JTGN01000005_gene2894	1.04e-31	124.0	COG1486@1|root,COG1486@2|Bacteria,1V6E5@1239|Firmicutes,24KU5@186801|Clostridia	186801|Clostridia	G	Family 4 glycosyl hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_4,Glyco_hydro_4C
k59_684512_1	1128421.JAGA01000004_gene2689	1.61e-55	194.0	COG1554@1|root,COG1554@2|Bacteria,2NQF1@2323|unclassified Bacteria	2|Bacteria	G	Glycosyl hydrolase family 65, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m
k59_296721_1	1226994.AMZB01000138_gene5564	9.13e-16	73.9	COG1393@1|root,COG1393@2|Bacteria,1MZ4Z@1224|Proteobacteria,1S8XH@1236|Gammaproteobacteria,1YGEY@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	P	arsenate reductase	arsC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	1.20.4.1	ko:K00537	-	-	-	-	ko00000,ko01000	-	-	-	ArsC
k59_296721_2	72664.XP_006392767.1	6.64e-17	78.6	COG0229@1|root,KOG0856@2759|Eukaryota,37I4S@33090|Viridiplantae,3GE85@35493|Streptophyta,3HTRG@3699|Brassicales	35493|Streptophyta	O	methionine sulfoxide reductase	MSRB1	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0016491,GO:0016667,GO:0016671,GO:0033743,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0050896,GO:0055114	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
k59_1352978_1	1120949.KB903294_gene4040	3.18e-15	78.2	COG1228@1|root,COG1228@2|Bacteria,2I98N@201174|Actinobacteria,4DBJX@85008|Micromonosporales	201174|Actinobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,Amidohydro_3
k59_574041_1	1157708.KB907452_gene3748	1.89e-18	84.0	COG1721@1|root,COG1721@2|Bacteria,1Q7RR@1224|Proteobacteria,2VJHU@28216|Betaproteobacteria,4A9S6@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
k59_574041_2	887062.HGR_15844	3.72e-18	85.5	COG2304@1|root,COG2304@2|Bacteria,1MXQ7@1224|Proteobacteria,2VHRY@28216|Betaproteobacteria,4ACKS@80864|Comamonadaceae	28216|Betaproteobacteria	S	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	BatA,VWA,VWA_2
k59_129138_1	323261.Noc_0233	3.24e-70	220.0	COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,1RMVK@1236|Gammaproteobacteria,1WW3W@135613|Chromatiales	135613|Chromatiales	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
k59_574054_1	926569.ANT_01260	3.58e-86	263.0	COG0549@1|root,COG0549@2|Bacteria,2G6C7@200795|Chloroflexi	200795|Chloroflexi	E	Amino acid kinase family	-	-	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	-	AA_kinase
k59_407990_1	267608.RSc1505	2.83e-10	60.8	COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,2VHZ4@28216|Betaproteobacteria,1K1RM@119060|Burkholderiaceae	28216|Betaproteobacteria	S	alcohol dehydrogenase	-	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N
k59_36075_2	1187851.A33M_3732	1.15e-58	196.0	COG0031@1|root,COG0031@2|Bacteria,1QQKZ@1224|Proteobacteria,2TUZQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	PALP
k59_1646995_1	1379270.AUXF01000005_gene385	1.15e-17	88.2	COG2812@1|root,COG2812@2|Bacteria,1ZTFV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
k59_483714_1	1249627.D779_0847	1.13e-24	102.0	COG1418@1|root,COG1418@2|Bacteria,1RH6M@1224|Proteobacteria,1S2H2@1236|Gammaproteobacteria,1X2VB@135613|Chromatiales	135613|Chromatiales	S	mRNA catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_983614_1	1336233.JAEH01000030_gene256	0.000142	51.2	COG2304@1|root,COG2931@1|root,COG2304@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,1RMZW@1236|Gammaproteobacteria,2QESR@267890|Shewanellaceae	1236|Gammaproteobacteria	Q	PFAM Hemolysin-type calcium-binding region	lapA	-	-	ko:K12549	-	-	-	-	ko00000	-	-	-	Big_3_2,Cadherin_3,Calx-beta,HemolysinCabind,VWA,VWA_2
k59_1204132_1	246197.MXAN_1695	9.36e-37	144.0	COG0577@1|root,COG0577@2|Bacteria,1PIKV@1224|Proteobacteria	1224|Proteobacteria	V	ABC-type antimicrobial peptide transport system, permease component	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_1482994_1	994573.T472_0205760	5.66e-38	133.0	COG2030@1|root,COG2030@2|Bacteria,1V6MY@1239|Firmicutes,24NB6@186801|Clostridia,36M8N@31979|Clostridiaceae	186801|Clostridia	I	PFAM MaoC domain protein dehydratase	-	-	4.2.1.55	ko:K17865	ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200	M00373	R03027	RC00831	ko00000,ko00001,ko00002,ko01000	-	-	-	MaoC_dehydratas
k59_704895_1	330214.NIDE1608	2.73e-15	75.9	COG0296@1|root,COG0296@2|Bacteria	2|Bacteria	G	1,4-alpha-glucan branching enzyme activity	-	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	AMPK1_CBM,Alpha-amylase,Alpha-amylase_C,CBM_48
k59_928996_2	472759.Nhal_2142	1.42e-48	158.0	COG0838@1|root,COG0838@2|Bacteria,1RGUT@1224|Proteobacteria,1S644@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoA	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016021,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0031224,GO:0031226,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	e_coli_core.b2288,iAF1260.b2288,iAPECO1_1312.APECO1_4277,iB21_1397.B21_02173,iBWG_1329.BWG_2062,iE2348C_1286.E2348C_2428,iEC042_1314.EC042_2529,iEC55989_1330.EC55989_2532,iECABU_c1320.ECABU_c26200,iECBD_1354.ECBD_1373,iECB_1328.ECB_02213,iECDH10B_1368.ECDH10B_2450,iECDH1ME8569_1439.ECDH1ME8569_2225,iECD_1391.ECD_02213,iECED1_1282.ECED1_2752,iECH74115_1262.ECH74115_3427,iECIAI1_1343.ECIAI1_2362,iECIAI39_1322.ECIAI39_2435,iECO103_1326.ECO103_2752,iECO26_1355.ECO26_3276,iECOK1_1307.ECOK1_2521,iECP_1309.ECP_2327,iECS88_1305.ECS88_2435,iECSE_1348.ECSE_2545,iECSP_1301.ECSP_3162,iECUMN_1333.ECUMN_2627,iECW_1372.ECW_m2476,iECs_1301.ECs3172,iEKO11_1354.EKO11_1479,iETEC_1333.ETEC_2423,iEcDH1_1363.EcDH1_1369,iEcE24377_1341.EcE24377A_2581,iEcHS_1320.EcHS_A2437,iEcSMS35_1347.EcSMS35_2442,iEcolC_1368.EcolC_1364,iG2583_1286.G2583_2825,iJN746.PP_4119,iJO1366.b2288,iJR904.b2288,iLF82_1304.LF82_1539,iNRG857_1313.NRG857_11585,iSBO_1134.SBO_2321,iSDY_1059.SDY_2484,iSFV_1184.SFV_2355,iSF_1195.SF2364,iSFxv_1172.SFxv_2608,iSSON_1240.SSON_2345,iS_1188.S2499,iSbBS512_1146.SbBS512_E2664,iUMN146_1321.UM146_05375,iUTI89_1310.UTI89_C2568,iWFL_1372.ECW_m2476,iY75_1357.Y75_RS11995,ic_1306.c2829	Oxidored_q4
k59_146961_1	255470.cbdbA1105	1.6e-60	198.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,2G5SW@200795|Chloroflexi,34CN3@301297|Dehalococcoidia	301297|Dehalococcoidia	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
k59_869972_1	66373.JOFQ01000007_gene3331	2.96e-10	61.6	COG0662@1|root,COG0662@2|Bacteria,2I4MK@201174|Actinobacteria	201174|Actinobacteria	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_1371691_2	1121957.ATVL01000008_gene4409	1.3e-22	99.0	COG1472@1|root,COG1472@2|Bacteria,4NE90@976|Bacteroidetes,47UBJ@768503|Cytophagia	976|Bacteroidetes	G	Fibronectin type III-like domain	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
k59_425774_1	926569.ANT_13300	1.96e-16	83.6	COG0642@1|root,COG2203@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria,2GA77@200795|Chloroflexi	200795|Chloroflexi	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS_9
k59_537089_1	588581.Cpap_2592	2.68e-05	50.4	COG1032@1|root,COG1032@2|Bacteria,1TRZA@1239|Firmicutes,24B00@186801|Clostridia	186801|Clostridia	C	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
k59_1594016_1	1232410.KI421417_gene2808	2.91e-18	88.6	COG2801@1|root,COG2801@2|Bacteria,1NUYG@1224|Proteobacteria,42ZK0@68525|delta/epsilon subdivisions,2WUUJ@28221|Deltaproteobacteria,43URT@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	Homeodomain-like domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,rve
k59_370061_1	431943.CKL_1451	1.83e-31	124.0	COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes,247NQ@186801|Clostridia,36DUZ@31979|Clostridiaceae	186801|Clostridia	E	Aminotransferase	aspB	-	2.6.1.1	ko:K00812,ko:K10907	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	iHN637.CLJU_RS06550	Aminotran_1_2
k59_1261946_1	13690.CP98_04531	3.16e-35	135.0	COG1216@1|root,COG1216@2|Bacteria,1QUUA@1224|Proteobacteria,2U1P5@28211|Alphaproteobacteria,2K69K@204457|Sphingomonadales	204457|Sphingomonadales	S	Glycosyl transferase family 21	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_370065_1	749927.AMED_4012	6.71e-11	68.9	COG0318@1|root,COG0318@2|Bacteria,2IB3B@201174|Actinobacteria,4E95Y@85010|Pseudonocardiales	201174|Actinobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	6.1.3.1	ko:K22319	-	-	-	-	ko00000,ko01000	-	-	-	AMP-binding,AMP-binding_C
k59_1371712_1	1110502.TMO_0012	7.03e-42	151.0	COG2159@1|root,COG2159@2|Bacteria,1N0C7@1224|Proteobacteria,2TRXY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	PFAM amidohydrolase	MA20_19310	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
k59_1261971_1	1379270.AUXF01000002_gene1585	7.23e-79	259.0	COG0515@1|root,COG0515@2|Bacteria,1ZUMJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
k59_315977_1	63577.G9NXE6	3.71e-18	83.6	2D4AX@1|root,2SUI3@2759|Eukaryota,3ANAS@33154|Opisthokonta,3PE3Q@4751|Fungi,3QZKJ@4890|Ascomycota,21F0A@147550|Sordariomycetes,3TMX5@5125|Hypocreales	4751|Fungi	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_315977_2	543632.JOJL01000010_gene7155	0.000104	45.1	COG2128@1|root,COG2128@2|Bacteria,2ICVV@201174|Actinobacteria,4DCWM@85008|Micromonosporales	201174|Actinobacteria	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
k59_370080_1	1122951.ATUE01000006_gene1247	2.14e-06	48.5	COG1932@1|root,COG1932@2|Bacteria,1MUB5@1224|Proteobacteria,1RMKU@1236|Gammaproteobacteria,3NKGT@468|Moraxellaceae	1236|Gammaproteobacteria	E	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	GO:0003674,GO:0003824,GO:0004648,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006520,GO:0006553,GO:0006563,GO:0006564,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009085,GO:0009089,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019752,GO:0019842,GO:0030170,GO:0033359,GO:0034641,GO:0036094,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046394,GO:0046451,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901615,GO:1901617	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iEcE24377_1341.EcE24377A_1004,iPC815.YPO1389,iYL1228.KPN_00935	Aminotran_5
k59_370080_2	1207076.ALAT01000115_gene3635	3.11e-52	186.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,1RN03@1236|Gammaproteobacteria,1YZWK@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0018130,GO:0019438,GO:0032774,GO:0034335,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042493,GO:0042623,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097659,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_646578_1	1379270.AUXF01000005_gene645	9.97e-13	69.3	COG2366@1|root,COG2366@2|Bacteria,1ZTBG@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
k59_646578_2	1034943.BN1094_01646	4.72e-19	87.8	COG1804@1|root,COG1804@2|Bacteria,1N7RG@1224|Proteobacteria,1RY6T@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	carnitine dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_1261983_1	1282876.BAOK01000001_gene2124	1.81e-99	308.0	COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,2TQJ7@28211|Alphaproteobacteria,4BPKE@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity	katG	-	1.11.1.21	ko:K03782	ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110	-	R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906	RC00034,RC00213,RC00767,RC02141	ko00000,ko00001,ko01000	-	-	-	peroxidase
k59_370093_1	1238182.C882_0490	5.83e-58	202.0	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2TQY9@28211|Alphaproteobacteria,2JQJ8@204441|Rhodospirillales	204441|Rhodospirillales	S	transport system, fused permease components	-	-	-	-	-	-	-	-	-	-	-	-	DUF3394,DctM
k59_1426575_1	1121448.DGI_0412	2.4e-65	211.0	COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,42MDM@68525|delta/epsilon subdivisions,2WJ5Y@28221|Deltaproteobacteria,2M9IV@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
k59_1483061_1	555088.DealDRAFT_3022	1.92e-05	44.3	2EHTG@1|root,33BJ4@2|Bacteria	2|Bacteria	S	Flp Fap pilin component	-	-	-	-	-	-	-	-	-	-	-	-	Flp_Fap
k59_704965_1	46429.BV95_01891	1.88e-47	169.0	COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2TQKQ@28211|Alphaproteobacteria,2K0FF@204457|Sphingomonadales	204457|Sphingomonadales	E	Belongs to the GMC oxidoreductase family	-	-	1.1.99.1	ko:K00108	ko00260,ko01100,map00260,map01100	M00555	R01025	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
k59_1483065_1	861299.J421_2290	1.04e-10	61.6	COG1600@1|root,COG1600@2|Bacteria,1ZU4X@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	-	-	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Fer4_16
k59_1706579_1	582744.Msip34_1308	6.34e-42	149.0	COG0789@1|root,COG5012@1|root,COG0789@2|Bacteria,COG5012@2|Bacteria,1R2NF@1224|Proteobacteria,2VJDG@28216|Betaproteobacteria	28216|Betaproteobacteria	K	PFAM regulatory protein, MerR	-	-	-	ko:K22491	-	-	-	-	ko00000,ko03000	-	-	-	B12-binding,B12-binding_2,MerR_1
k59_425839_1	161156.JQKW01000006_gene1264	1.27e-42	155.0	COG2204@1|root,COG2204@2|Bacteria,2GGZ6@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	T	AAA domain (Cdc48 subfamily)	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_316020_1	1397528.Q671_01775	1.39e-52	171.0	COG0245@1|root,COG0245@2|Bacteria,1MVHA@1224|Proteobacteria,1S3RQ@1236|Gammaproteobacteria,1XJPI@135619|Oceanospirillales	135619|Oceanospirillales	I	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	4.6.1.12	ko:K01770	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	YgbB
k59_36178_1	1120956.JHZK01000022_gene1553	6.99e-47	164.0	COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria,1JPR3@119043|Rhodobiaceae	28211|Alphaproteobacteria	Q	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_759315_1	1122175.ATXU01000005_gene2528	2.68e-31	119.0	COG0414@1|root,COG0414@2|Bacteria,2GJEQ@201174|Actinobacteria,4FN3G@85023|Microbacteriaceae	201174|Actinobacteria	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	-	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
k59_759315_2	1137271.AZUM01000002_gene2860	1.64e-08	55.8	COG5495@1|root,COG5495@2|Bacteria,2I2F6@201174|Actinobacteria,4DZM6@85010|Pseudonocardiales	201174|Actinobacteria	S	Domain of unknown function (DUF2520)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2520,Rossmann-like
k59_92134_1	1379270.AUXF01000002_gene1290	1.97e-36	144.0	COG0515@1|root,COG0515@2|Bacteria,1ZUFG@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
k59_1758626_1	867845.KI911784_gene3384	1.28e-27	115.0	COG0515@1|root,COG0515@2|Bacteria,2GBWC@200795|Chloroflexi,375DM@32061|Chloroflexia	32061|Chloroflexia	KLT	Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
k59_929095_1	1541959.KQ51_00837	4.09e-18	82.8	COG1164@1|root,COG1164@2|Bacteria,3WU9G@544448|Tenericutes	544448|Tenericutes	E	Oligopeptidase F	pepF1_1	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M3,Peptidase_M3_N
k59_929095_2	485913.Krac_2177	3.28e-06	49.3	COG1164@1|root,COG1164@2|Bacteria,2G5JB@200795|Chloroflexi	200795|Chloroflexi	E	PFAM peptidase M3A and M3B, thimet oligopeptidase F	-	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
k59_147052_2	1123278.KB893581_gene1044	2.58e-20	86.3	COG0693@1|root,COG0693@2|Bacteria,4NQI1@976|Bacteroidetes,47PAI@768503|Cytophagia	976|Bacteroidetes	S	Intracellular protease, PfpI family	-	-	3.5.1.124	ko:K05520	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DJ-1_PfpI
k59_36188_1	1123020.AUIE01000010_gene1146	1.59e-110	335.0	COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,1SZFR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	Multicopper oxidase	-	-	1.16.3.3	ko:K06324	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
k59_983722_1	743721.Psesu_0448	7.89e-48	169.0	COG3934@1|root,COG3934@2|Bacteria,1N159@1224|Proteobacteria,1RRC1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	3.2.1.78	ko:K19355	ko00051,map00051	-	R01332	RC00467	ko00000,ko00001,ko01000	-	-	-	Cellulase
k59_258244_1	1089553.Tph_c22350	8.33e-11	63.5	COG1228@1|root,COG1228@2|Bacteria,1TPNQ@1239|Firmicutes,248UT@186801|Clostridia,42EZJ@68295|Thermoanaerobacterales	186801|Clostridia	Q	PFAM amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,Amidohydro_3
k59_258244_2	234267.Acid_4721	7e-12	62.8	COG1695@1|root,COG1695@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	ko:K10947	-	-	-	-	ko00000,ko03000	-	-	-	PadR
k59_592170_1	765911.Thivi_2243	1.42e-66	217.0	COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,1RNE4@1236|Gammaproteobacteria,1WW0B@135613|Chromatiales	135613|Chromatiales	P	Acts as a magnesium transporter	-	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
k59_705009_1	592015.HMPREF1705_01943	5.12e-87	273.0	COG1884@1|root,COG1884@2|Bacteria,3T9QP@508458|Synergistetes	508458|Synergistetes	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
k59_1149722_1	118161.KB235922_gene2606	4.41e-58	198.0	COG5421@1|root,COG5421@2|Bacteria,1G3YW@1117|Cyanobacteria	1117|Cyanobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_1758658_1	452637.Oter_1368	1.39e-41	158.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_1426645_1	1094715.CM001373_gene2690	3.41e-23	100.0	COG3590@1|root,COG3590@2|Bacteria,1MVNQ@1224|Proteobacteria,1RNNA@1236|Gammaproteobacteria,1JDG7@118969|Legionellales	118969|Legionellales	O	Peptidase family M13	pepO	-	-	ko:K07386	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M13,Peptidase_M13_N
k59_1426645_2	1386089.N865_07300	7.13e-37	137.0	2B189@1|root,31TNP@2|Bacteria,2GSQX@201174|Actinobacteria,4FGMD@85021|Intrasporangiaceae	201174|Actinobacteria	S	Ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
k59_258285_1	404589.Anae109_0939	1.26e-75	249.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,1MVWY@1224|Proteobacteria,42U99@68525|delta/epsilon subdivisions,2WQ5W@28221|Deltaproteobacteria,2YWMR@29|Myxococcales	28221|Deltaproteobacteria	L	ATP dependent DNA ligase domain protein	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
k59_1537328_1	234267.Acid_5856	3.34e-23	100.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria	57723|Acidobacteria	KLTU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
k59_259999_1	1120956.JHZK01000012_gene3639	6.89e-86	276.0	COG1060@1|root,COG1060@2|Bacteria,1MX50@1224|Proteobacteria,2TRX7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	synthase	fbiC	-	2.5.1.77	ko:K11779	ko00680,ko01120,map00680,map01120	M00378	R09396	RC01381,RC03002,RC03007	ko00000,ko00001,ko00002,ko01000	-	-	-	CofC,Radical_SAM
k59_871966_1	1125863.JAFN01000001_gene3011	2.56e-09	58.5	COG2386@1|root,COG2386@2|Bacteria,1QF23@1224|Proteobacteria,42RAM@68525|delta/epsilon subdivisions,2WMS1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	ccmB	-	-	ko:K02194	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	CcmB
k59_871966_2	1424334.W822_08700	0.000212	46.2	COG1116@1|root,COG1116@2|Bacteria,1MUKI@1224|Proteobacteria,2W8XH@28216|Betaproteobacteria,3T7F6@506|Alcaligenaceae	28216|Betaproteobacteria	P	Part of the ABC transporter complex SsuABC involved in aliphatic sulfonates import. Responsible for energy coupling to the transport system	-	-	-	ko:K15555	ko00920,ko02010,map00920,map02010	M00436	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.17.2	-	-	ABC_tran
k59_931098_2	755178.Cyan10605_2109	8.61e-21	93.2	COG4301@1|root,COG4301@2|Bacteria,1G2JI@1117|Cyanobacteria	1117|Cyanobacteria	S	conserved protein (DUF2260)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_33
k59_1596025_1	861299.J421_3301	2.24e-74	232.0	COG0039@1|root,COG0039@2|Bacteria,1ZSV3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	-	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
k59_1319008_1	575540.Isop_0840	5e-79	259.0	COG1048@1|root,COG1048@2|Bacteria,2IY29@203682|Planctomycetes	203682|Planctomycetes	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k59_317995_2	1121931.AUHG01000016_gene1010	1.38e-43	159.0	COG0531@1|root,COG0531@2|Bacteria,4NFFX@976|Bacteroidetes,1HZT1@117743|Flavobacteriia	976|Bacteroidetes	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease,SLC12
k59_871992_1	1121904.ARBP01000001_gene5374	6.08e-16	77.8	COG0500@1|root,COG2226@2|Bacteria,4PM1K@976|Bacteroidetes,47YPA@768503|Cytophagia	976|Bacteroidetes	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23,Methyltransf_25,Methyltransf_31
k59_871992_2	1041522.MCOL_V213710	2.17e-20	91.3	COG1018@1|root,COG2258@1|root,COG1018@2|Bacteria,COG2258@2|Bacteria,2HMUS@201174|Actinobacteria,232VB@1762|Mycobacteriaceae	201174|Actinobacteria	C	3-alpha domain	-	-	-	-	-	-	-	-	-	-	-	-	3-alpha,FAD_binding_6,Fer2,MOSC,NAD_binding_1
k59_1319012_1	1168059.KB899087_gene3833	5.48e-66	214.0	COG3875@1|root,COG3875@2|Bacteria,1R79Y@1224|Proteobacteria,2U4VR@28211|Alphaproteobacteria,3F0QU@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
k59_1151516_1	1218084.BBJK01000075_gene5239	5.7e-36	140.0	COG2909@1|root,COG3629@1|root,COG2909@2|Bacteria,COG3629@2|Bacteria,1MVZZ@1224|Proteobacteria,2VXDK@28216|Betaproteobacteria,1K5E1@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	BTAD
k59_816965_1	1122176.KB903540_gene4	1.82e-46	160.0	COG0350@1|root,COG2169@1|root,COG0350@2|Bacteria,COG2169@2|Bacteria,4NFYC@976|Bacteroidetes,1IPQ6@117747|Sphingobacteriia	976|Bacteroidetes	FL	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	ogt	-	2.1.1.63	ko:K00567,ko:K10778	-	-	-	-	ko00000,ko01000,ko03000,ko03400	-	-	-	Ada_Zn_binding,DNA_binding_1,HTH_18,Methyltransf_1N
k59_816965_2	1121931.AUHG01000016_gene1010	2.33e-27	112.0	COG0531@1|root,COG0531@2|Bacteria,4NFFX@976|Bacteroidetes,1HZT1@117743|Flavobacteriia	976|Bacteroidetes	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease,SLC12
k59_1264174_1	1198114.AciX9_1802	1.14e-60	201.0	COG0535@1|root,COG0535@2|Bacteria,3Y5QY@57723|Acidobacteria,2JM3D@204432|Acidobacteriia	204432|Acidobacteriia	S	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM,SPASM
k59_317999_1	357808.RoseRS_1258	8.46e-42	155.0	COG0803@1|root,COG0803@2|Bacteria,2G8F6@200795|Chloroflexi,37738@32061|Chloroflexia	32061|Chloroflexia	P	Belongs to the bacterial solute-binding protein 9 family	-	-	-	ko:K02077,ko:K09818	-	M00243,M00244	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ZnuA
k59_1596039_1	414684.RC1_1907	9.03e-51	167.0	COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,2U5P0@28211|Alphaproteobacteria,2JSBM@204441|Rhodospirillales	204441|Rhodospirillales	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	-	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
k59_498999_1	110319.CF8_0950	8.68e-88	275.0	COG1884@1|root,COG1884@2|Bacteria,2GM65@201174|Actinobacteria,4DPNX@85009|Propionibacteriales	201174|Actinobacteria	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
k59_1661766_1	1131269.AQVV01000017_gene1978	2.91e-58	204.0	COG0587@1|root,COG0587@2|Bacteria	2|Bacteria	L	DNA-directed DNA polymerase activity	dnaE	GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032991,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0046483,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,RNase_T,tRNA_anti-codon
k59_829334_1	420324.KI911943_gene5259	1.76e-30	122.0	COG2866@1|root,COG2866@2|Bacteria,1MZYN@1224|Proteobacteria,2U7BT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Zn_pept	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
k59_214736_1	485914.Hmuk_2850	4.29e-10	61.6	COG0484@1|root,arCOG02846@2157|Archaea,2XV5D@28890|Euryarchaeota,23S61@183963|Halobacteria	183963|Halobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
k59_214736_2	1434325.AZQN01000001_gene468	1.75e-08	58.5	COG1385@1|root,COG1385@2|Bacteria,4NE2S@976|Bacteroidetes,47PRE@768503|Cytophagia	976|Bacteroidetes	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	rsmE	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
k59_440114_1	1123242.JH636436_gene323	1.02e-72	233.0	COG1363@1|root,COG1363@2|Bacteria,2IXMY@203682|Planctomycetes	203682|Planctomycetes	G	COG1363 Cellulase M and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
k59_886128_1	379066.GAU_1170	1.17e-60	196.0	COG0568@1|root,COG0568@2|Bacteria,1ZSR6@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_720828_1	1245471.PCA10_45370	6.36e-102	306.0	COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,1RPGJ@1236|Gammaproteobacteria,1YCZD@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	E	Alanine-glyoxylate amino-transferase	dapC	-	2.6.1.17	ko:K14261,ko:K14267	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04475	RC00006	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_1165466_1	583355.Caka_2045	8.6e-27	114.0	COG0771@1|root,COG2911@1|root,COG2931@1|root,COG0771@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	murD	-	3.4.21.10,6.3.2.13,6.3.2.9	ko:K01317,ko:K01925,ko:K01928,ko:K01932	ko00300,ko00471,ko00550,ko01100,map00300,map00471,map00550,map01100	-	R02783,R02788	RC00064,RC00090,RC00141	ko00000,ko00001,ko01000,ko01002,ko01011,ko04131	-	-	-	DUF1727,Mur_ligase_C,Mur_ligase_M
k59_385183_1	671143.DAMO_1697	2.04e-118	357.0	COG0004@1|root,COG0004@2|Bacteria,2NP8F@2323|unclassified Bacteria	2|Bacteria	P	Ammonium Transporter Family	nrgA	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_1661815_1	742726.HMPREF9448_01007	1.41e-43	150.0	COG0558@1|root,COG0558@2|Bacteria,4NHG2@976|Bacteroidetes,2FSDD@200643|Bacteroidia,231JF@171551|Porphyromonadaceae	976|Bacteroidetes	I	CDP-alcohol phosphatidyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	CDP-OH_P_transf
k59_1053839_1	1379270.AUXF01000007_gene858	1.17e-49	178.0	COG0515@1|root,COG0515@2|Bacteria,1ZUAC@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
k59_660118_1	765912.Thimo_2071	5.23e-48	162.0	COG1173@1|root,COG1173@2|Bacteria,1MW3R@1224|Proteobacteria,1SYJC@1236|Gammaproteobacteria,1WW83@135613|Chromatiales	135613|Chromatiales	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_106364_1	639030.JHVA01000001_gene3306	1.37e-19	93.6	COG1200@1|root,COG1200@2|Bacteria,3Y31Z@57723|Acidobacteria,2JHRS@204432|Acidobacteriia	204432|Acidobacteriia	L	ATP-dependent DNA helicase RecG	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
k59_1387341_1	278963.ATWD01000001_gene3376	2.85e-75	231.0	COG5405@1|root,COG5405@2|Bacteria,3Y42U@57723|Acidobacteria,2JIR7@204432|Acidobacteriia	204432|Acidobacteriia	O	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery	hslV	-	3.4.25.2	ko:K01419	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Proteasome
k59_1661828_1	392499.Swit_4130	7.08e-16	79.0	28JZZ@1|root,2Z9PZ@2|Bacteria,1N3C6@1224|Proteobacteria,2TSCX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_720866_1	879243.Poras_1656	8.7e-37	142.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,4NETS@976|Bacteroidetes,2FNBA@200643|Bacteroidia,22WW6@171551|Porphyromonadaceae	976|Bacteroidetes	EU	Peptidase, S9A B C family, catalytic domain protein	dpp	-	3.4.14.5	ko:K01278	ko04974,map04974	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	DPPIV_N,Peptidase_S9
k59_214785_1	1121481.AUAS01000013_gene4299	1.21e-35	134.0	COG4447@1|root,COG4447@2|Bacteria,4NGUK@976|Bacteroidetes,47NCA@768503|Cytophagia	976|Bacteroidetes	S	protein related to plant photosystem II stability assembly factor	-	-	-	-	-	-	-	-	-	-	-	-	BNR,PSII_BNR,Sortilin-Vps10
k59_772465_1	1279009.ADICEAN_02929	1.82e-36	135.0	COG2010@1|root,COG2010@2|Bacteria,4NHQV@976|Bacteroidetes,47PEN@768503|Cytophagia	976|Bacteroidetes	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
k59_1387355_1	671143.DAMO_1234	1.13e-58	184.0	COG1569@1|root,COG1569@2|Bacteria	2|Bacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN_3
k59_1387355_2	671143.DAMO_1235	2.59e-25	96.3	COG0864@1|root,COG0864@2|Bacteria	2|Bacteria	K	response to nickel cation	ndoAI	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K07723	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	RHH_1
k59_1332994_1	1379270.AUXF01000005_gene764	3.99e-68	227.0	COG2366@1|root,COG2366@2|Bacteria,1ZUMU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Penicillin amidase	-	-	3.5.1.97	ko:K07116	-	-	-	-	ko00000,ko01000	-	-	-	Penicil_amidase
k59_385217_1	661478.OP10G_1294	2.16e-45	166.0	COG3533@1|root,COG3533@2|Bacteria	2|Bacteria	S	Beta-L-arabinofuranosidase, GH127	-	-	-	ko:K09955	-	-	-	-	ko00000	-	-	-	F5_F8_type_C,Glyco_hydro_127
k59_385217_2	1079460.ATTQ01000001_gene5909	1.31e-05	46.2	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TRFN@28211|Alphaproteobacteria,4B8PD@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL	-	-	1.17.1.4	ko:K11177	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_106390_1	207954.MED92_16285	3.68e-92	301.0	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,1RMRN@1236|Gammaproteobacteria,1XH4B@135619|Oceanospirillales	135619|Oceanospirillales	F	Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS_C,GATase_5
k59_1053890_1	195105.CN97_15380	6.71e-12	70.9	2A1MP@1|root,30PVX@2|Bacteria,1R4FS@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1498908_1	868595.Desca_1359	3.18e-62	214.0	COG1615@1|root,COG1615@2|Bacteria,1TQHM@1239|Firmicutes,248PM@186801|Clostridia,260EY@186807|Peptococcaceae	186801|Clostridia	S	PFAM Uncharacterised protein family UPF0182	-	-	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
k59_499138_1	7159.AAEL000581-PA	9.11e-05	45.1	COG0145@1|root,KOG1939@2759|Eukaryota,38C8D@33154|Opisthokonta,3BHEN@33208|Metazoa,3CYN2@33213|Bilateria,41U6K@6656|Arthropoda,3SJ1Y@50557|Insecta,44YHP@7147|Diptera,45GJD@7148|Nematocera	33208|Metazoa	E	Hydantoinase B/oxoprolinase	OPLAH	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006518,GO:0006575,GO:0006749,GO:0006750,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0017168,GO:0019184,GO:0034641,GO:0042398,GO:0043043,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901564,GO:1901566,GO:1901576	3.5.2.9	ko:K01469	ko00480,map00480	-	R00251	RC00553	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A,Hydantoinase_B
k59_106411_1	1001240.GY21_01310	0.000114	45.4	COG0156@1|root,COG0156@2|Bacteria,2GISV@201174|Actinobacteria,4FKF5@85023|Microbacteriaceae	201174|Actinobacteria	H	Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2,KR,PP-binding,PS-DH
k59_1441178_1	1125863.JAFN01000001_gene1724	1.53e-05	46.6	COG2890@1|root,COG2890@2|Bacteria,1MXCQ@1224|Proteobacteria,42PKA@68525|delta/epsilon subdivisions,2WNH0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_31
k59_1441178_2	1246484.D479_00345	1.34e-49	169.0	COG0216@1|root,COG0216@2|Bacteria,1TQ7V@1239|Firmicutes,4H9MB@91061|Bacilli,3NDGI@45667|Halobacillus	91061|Bacilli	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
k59_660180_1	158500.BV97_04308	7.03e-53	178.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,2K2SD@204457|Sphingomonadales	204457|Sphingomonadales	L	Transposase	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1053916_1	319795.Dgeo_0312	1.51e-07	58.2	COG1361@1|root,COG1361@2|Bacteria,1WNF4@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	Domain of unknown function DUF11	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
k59_1550003_1	1124780.ANNU01000018_gene1669	5.7e-52	176.0	COG3328@1|root,COG3328@2|Bacteria,4NFQS@976|Bacteroidetes,47NSF@768503|Cytophagia	976|Bacteroidetes	L	Transposase, Mutator family	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_1498923_1	40571.JOEA01000016_gene134	3.85e-11	63.9	COG0596@1|root,COG0596@2|Bacteria,2H1QB@201174|Actinobacteria,4E4RR@85010|Pseudonocardiales	201174|Actinobacteria	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
k59_605086_1	1168067.JAGP01000001_gene270	9.88e-48	157.0	COG0096@1|root,COG0096@2|Bacteria,1RDG3@1224|Proteobacteria,1S452@1236|Gammaproteobacteria,460S8@72273|Thiotrichales	72273|Thiotrichales	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	-	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
k59_605086_2	1122185.N792_03400	9.4e-05	43.5	COG0097@1|root,COG0097@2|Bacteria,1R9YZ@1224|Proteobacteria,1S1Z1@1236|Gammaproteobacteria,1X3Q7@135614|Xanthomonadales	135614|Xanthomonadales	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
k59_944022_2	985665.HPL003_26545	2.44e-12	68.6	COG2896@1|root,COG2896@2|Bacteria,1TP89@1239|Firmicutes,4HAKQ@91061|Bacilli,26T0E@186822|Paenibacillaceae	91061|Bacilli	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
k59_499159_1	1379270.AUXF01000006_gene179	2.67e-16	79.3	COG1703@1|root,COG1703@2|Bacteria,1ZT8J@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	ArgK protein	-	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
k59_499159_2	1499967.BAYZ01000182_gene4426	1.01e-27	110.0	COG2233@1|root,COG2233@2|Bacteria,2NP6F@2323|unclassified Bacteria	2|Bacteria	F	Permease family	pyrP	-	-	ko:K02824	-	-	-	-	ko00000,ko02000	2.A.40.1.1,2.A.40.1.2	-	-	Xan_ur_permease
k59_944035_1	1317118.ATO8_20949	6.34e-18	83.6	COG1595@1|root,COG1595@2|Bacteria,1RBM4@1224|Proteobacteria,2U5KD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_944035_3	702113.PP1Y_AT23330	5.05e-25	94.4	COG2020@1|root,COG2020@2|Bacteria	2|Bacteria	O	methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
k59_605098_1	583345.Mmol_1288	1.85e-85	261.0	COG0825@1|root,COG0825@2|Bacteria,1MURN@1224|Proteobacteria,2VHS0@28216|Betaproteobacteria,2KKTB@206350|Nitrosomonadales	206350|Nitrosomonadales	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA	accA	-	2.1.3.15,6.4.1.2	ko:K01962	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	ACCA,MdcE
k59_550799_1	1123322.KB904675_gene3038	1.23e-15	81.3	COG0477@1|root,COG0477@2|Bacteria,2GK06@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
k59_886292_1	926569.ANT_29620	7.33e-71	225.0	COG1180@1|root,COG1180@2|Bacteria,2G6B2@200795|Chloroflexi	200795|Chloroflexi	C	PFAM Radical SAM domain protein	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
k59_214862_1	653733.Selin_1263	7.22e-66	211.0	COG0061@1|root,COG0061@2|Bacteria	2|Bacteria	H	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006766,GO:0006767,GO:0006769,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008976,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009820,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016776,GO:0017076,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	iEcSMS35_1347.EcSMS35_2767,iHN637.CLJU_RS05480,iLJ478.TM1733,iSB619.SA_RS04895	NAD_kinase
k59_944070_1	338966.Ppro_1798	3.75e-52	181.0	COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,42M6V@68525|delta/epsilon subdivisions,2WJCI@28221|Deltaproteobacteria,43SXP@69541|Desulfuromonadales	28221|Deltaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
k59_1661926_1	525146.Ddes_0533	2.95e-07	55.5	COG2854@1|root,COG2854@2|Bacteria,1NKFA@1224|Proteobacteria,42U8G@68525|delta/epsilon subdivisions,2WQPS@28221|Deltaproteobacteria,2MAXD@213115|Desulfovibrionales	28221|Deltaproteobacteria	Q	PFAM toluene tolerance family protein	-	-	-	ko:K07323	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	MlaC
k59_886308_1	1246448.ANAZ01000002_gene3860	1.96e-14	77.4	COG0412@1|root,COG0412@2|Bacteria,2GNWB@201174|Actinobacteria	201174|Actinobacteria	Q	Dienelactone hydrolase	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
k59_1498989_1	639283.Snov_3821	2.85e-48	157.0	COG1396@1|root,COG1396@2|Bacteria,1N1CT@1224|Proteobacteria,2UCMF@28211|Alphaproteobacteria,3EZQ3@335928|Xanthobacteraceae	28211|Alphaproteobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31
k59_1498989_2	1238182.C882_3205	7.3e-12	63.2	COG2840@1|root,COG2840@2|Bacteria,1RH34@1224|Proteobacteria,2UCM1@28211|Alphaproteobacteria,2JSTF@204441|Rhodospirillales	204441|Rhodospirillales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Smr
k59_605131_1	906968.Trebr_1155	2.7e-55	189.0	COG2204@1|root,COG2204@2|Bacteria,2J5NY@203691|Spirochaetes	203691|Spirochaetes	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	rrp-2	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_499213_1	3702.AT1G31220.1	5.7e-39	141.0	COG0299@1|root,KOG3076@2759|Eukaryota,37RA4@33090|Viridiplantae,3GD7R@35493|Streptophyta,3HSPH@3699|Brassicales	35493|Streptophyta	G	phosphoribosylglycinamide formyltransferase	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009536,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464	2.1.2.2	ko:K00601	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N
k59_829517_1	1120958.AULD01000006_gene192	4.95e-16	75.1	COG0792@1|root,COG0792@2|Bacteria,2IQ3X@201174|Actinobacteria,4FPTI@85023|Microbacteriaceae	201174|Actinobacteria	L	nucleic acid phosphodiester bond hydrolysis	yraN	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
k59_108255_1	861299.J421_2171	2.44e-43	160.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,1ZSS1@142182|Gemmatimonadetes	2|Bacteria	O	Tricorn protease homolog	-	-	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
k59_1721044_1	190650.CC_0401	4.73e-13	65.5	COG3070@1|root,COG3070@2|Bacteria,1N8X8@1224|Proteobacteria,2UFNC@28211|Alphaproteobacteria,2KJ5W@204458|Caulobacterales	204458|Caulobacterales	K	PFAM TfoX domain protein	-	-	-	ko:K07343	-	-	-	-	ko00000	-	-	-	TfoX_N
k59_1721044_2	1122603.ATVI01000005_gene3670	4.12e-15	78.6	COG1566@1|root,COG1566@2|Bacteria,1RJ3I@1224|Proteobacteria,1S7BS@1236|Gammaproteobacteria,1X4Y6@135614|Xanthomonadales	135614|Xanthomonadales	V	Protein of unknown function (DUF3667)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3667
k59_1721049_1	1128421.JAGA01000003_gene3481	1.38e-80	251.0	COG4586@1|root,COG4586@2|Bacteria,2NP49@2323|unclassified Bacteria	2|Bacteria	S	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_273142_1	930169.B5T_00269	8.31e-54	181.0	COG2267@1|root,COG2267@2|Bacteria,1RAQZ@1224|Proteobacteria,1S2YX@1236|Gammaproteobacteria,1XJ98@135619|Oceanospirillales	135619|Oceanospirillales	I	COG2267 Lysophospholipase	-	-	3.1.1.5	ko:K01048	ko00564,map00564	-	-	-	ko00000,ko00001,ko01000	-	-	-	Hydrolase_4
k59_888943_1	96561.Dole_1550	5.86e-42	154.0	COG1028@1|root,COG1545@1|root,COG3255@1|root,COG3425@1|root,COG1028@2|Bacteria,COG1545@2|Bacteria,COG3255@2|Bacteria,COG3425@2|Bacteria,1MXNQ@1224|Proteobacteria,42Q8V@68525|delta/epsilon subdivisions,2WJP0@28221|Deltaproteobacteria,2MHRA@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	PFAM short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	ACP_syn_III_C,DUF35_N,MaoC_dehydrat_N,MaoC_dehydratas,OB_aCoA_assoc,SCP2,adh_short
k59_888943_2	1231392.OCGS_2830	2.67e-08	53.9	COG0183@1|root,COG0183@2|Bacteria,1MU8C@1224|Proteobacteria,2TS6P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_108298_1	1469245.JFBG01000063_gene2351	4.35e-72	241.0	COG0112@1|root,COG0404@1|root,COG0112@2|Bacteria,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,1RN2A@1236|Gammaproteobacteria,1WWZ0@135613|Chromatiales	135613|Chromatiales	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
k59_662427_1	990285.RGCCGE502_03962	9.13e-19	86.7	COG0583@1|root,COG0583@2|Bacteria,1N0HM@1224|Proteobacteria,2U1WV@28211|Alphaproteobacteria,4B8AJ@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_662427_2	1207063.P24_06037	6.9e-13	68.2	COG1132@1|root,COG4988@1|root,COG1132@2|Bacteria,COG4988@2|Bacteria,1MUBM@1224|Proteobacteria,2U0IT@28211|Alphaproteobacteria,2JQVP@204441|Rhodospirillales	204441|Rhodospirillales	V	ABC transporter transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	ABC_membrane,ABC_tran
k59_1551851_1	768671.ThimaDRAFT_2784	9.86e-41	152.0	COG0834@1|root,COG1301@1|root,COG0834@2|Bacteria,COG1301@2|Bacteria,1P22C@1224|Proteobacteria,1RSGY@1236|Gammaproteobacteria,1WZZV@135613|Chromatiales	135613|Chromatiales	U	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_3,SDF
k59_888966_1	1227453.C444_03732	7.62e-12	68.9	arCOG08113@1|root,arCOG08113@2157|Archaea,2XV1B@28890|Euryarchaeota,23TAX@183963|Halobacteria	183963|Halobacteria	S	protein related to plant photosystem II stability assembly factor	-	-	-	-	-	-	-	-	-	-	-	-	BNR
k59_888969_1	1157708.KB907455_gene3167	5.27e-07	52.8	COG3845@1|root,COG3845@2|Bacteria,1NT0H@1224|Proteobacteria,2VN96@28216|Betaproteobacteria,4AC2H@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM ABC transporter related	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
k59_888969_2	479433.Caci_6564	7.32e-46	159.0	COG0842@1|root,COG0842@2|Bacteria,2GJ7Y@201174|Actinobacteria	201174|Actinobacteria	V	transport, permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC2_membrane_3
k59_216659_1	28072.Nos7524_4873	2.95e-11	62.4	COG0517@1|root,COG0517@2|Bacteria,1G5TQ@1117|Cyanobacteria,1HN52@1161|Nostocales	1117|Cyanobacteria	S	PFAM CBS domain	-	-	-	ko:K07182	-	-	-	-	ko00000	-	-	-	CBS
k59_216659_2	671143.DAMO_0980	1.62e-17	84.7	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,2NP1J@2323|unclassified Bacteria	2|Bacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	-	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_13,Fer4_6,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_1551864_1	1235796.C815_00229	9.05e-50	179.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes	1239|Firmicutes	P	P-type atpase	pmr1	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
k59_108334_1	1096930.L284_12485	9.11e-06	48.1	COG0543@1|root,COG0543@2|Bacteria,1RF43@1224|Proteobacteria,2U57Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Oxidoreductase, FAD-binding	-	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind,FAD_binding_6
k59_1110578_1	1095769.CAHF01000005_gene1441	1.07e-117	345.0	COG0037@1|root,COG0037@2|Bacteria,1MW5Q@1224|Proteobacteria,2VHWH@28216|Betaproteobacteria,473FX@75682|Oxalobacteraceae	28216|Betaproteobacteria	J	Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system	ttcA	-	-	ko:K14058	-	-	-	-	ko00000,ko03016	-	-	-	ATP_bind_3
k59_91392_2	1207063.P24_15524	1.44e-05	48.9	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2TRHH@28211|Alphaproteobacteria,2JQVJ@204441|Rhodospirillales	204441|Rhodospirillales	T	transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_7,PAS_9,Response_reg
k59_758574_1	1123236.KB899389_gene2141	4.07e-66	219.0	COG2234@1|root,COG2234@2|Bacteria,1MV86@1224|Proteobacteria,1RNNQ@1236|Gammaproteobacteria,464MC@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
k59_425091_1	545693.BMQ_1170	3.09e-09	56.2	COG1247@1|root,COG1247@2|Bacteria,1V4AZ@1239|Firmicutes,4HGZ3@91061|Bacilli,1ZFMB@1386|Bacillus	91061|Bacilli	M	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_1705830_1	1121943.KB900003_gene2855	1.26e-107	323.0	COG2079@1|root,COG2079@2|Bacteria,1NECN@1224|Proteobacteria,1SZV4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	MmgE PrpD family protein	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
k59_91401_1	1040989.AWZU01000005_gene184	5.85e-12	65.9	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria,3K3K1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_91401_2	631454.N177_0632	3.3e-46	153.0	COG2080@1|root,COG2080@2|Bacteria,1PGF7@1224|Proteobacteria,2V8HC@28211|Alphaproteobacteria,1JQ84@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	[2Fe-2S] binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer2,Fer2_2
k59_982957_2	1869.MB27_38625	1.04e-28	116.0	COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,2GJRI@201174|Actinobacteria,4D9YU@85008|Micromonosporales	201174|Actinobacteria	T	PFAM adenylyl cyclase class-3 4 guanylyl cyclase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Guanylate_cyc,TPR_12
k59_1705849_1	95619.PM1_0229070	8.89e-33	120.0	COG0712@1|root,COG0712@2|Bacteria,1MVRH@1224|Proteobacteria,1S8X2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	iSF_1195.SF3815,iSFxv_1172.SFxv_4157,iS_1188.S3953	OSCP
k59_1705849_2	1026882.MAMP_00732	3.68e-13	68.9	COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,1RP4V@1236|Gammaproteobacteria,460AE@72273|Thiotrichales	72273|Thiotrichales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
k59_1371025_1	1121920.AUAU01000025_gene2342	6.62e-43	157.0	COG0726@1|root,COG0726@2|Bacteria,3Y4FK@57723|Acidobacteria	57723|Acidobacteria	G	PFAM Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
k59_1092899_1	1122194.AUHU01000003_gene1985	1.08e-19	91.3	COG5653@1|root,COG5653@2|Bacteria,1QUMR@1224|Proteobacteria,1RN5W@1236|Gammaproteobacteria,464GN@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_6,Seryl_tRNA_N
k59_758600_1	1123392.AQWL01000008_gene1237	5.17e-14	78.2	COG3299@1|root,COG3299@2|Bacteria,1P3E0@1224|Proteobacteria,2VKDQ@28216|Betaproteobacteria	28216|Betaproteobacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	Baseplate_J,PA14
k59_1039279_1	1144275.COCOR_03761	1.82e-35	140.0	COG0577@1|root,COG0577@2|Bacteria,1NREW@1224|Proteobacteria	1224|Proteobacteria	V	COG0577 ABC-type antimicrobial peptide transport system permease component	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_928311_1	1227488.C477_01540	2.57e-67	219.0	COG0277@1|root,arCOG00340@2157|Archaea,2Y85H@28890|Euryarchaeota,24157@183963|Halobacteria	183963|Halobacteria	C	COG0277 FAD FMN-containing dehydrogenases	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
k59_483126_1	1538644.KO02_10405	0.000287	48.9	COG3637@1|root,COG3637@2|Bacteria,4NE4Y@976|Bacteroidetes	976|Bacteroidetes	M	RagB, SusD	-	-	-	ko:K21572	-	-	-	-	ko00000,ko02000	8.A.46.1,8.A.46.3	-	-	SusD-like_3,SusD_RagB
k59_982985_1	693977.Deipr_1497	1.63e-26	107.0	COG0286@1|root,COG0286@2|Bacteria,1WI3E@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	L	HsdM N-terminal domain	-	-	2.1.1.72	ko:K03427	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HsdM_N,N6_Mtase
k59_1425874_1	1121875.KB907547_gene3141	6.22e-124	354.0	COG0377@1|root,COG0377@2|Bacteria,4NFKT@976|Bacteroidetes,1I0R8@117743|Flavobacteriia	976|Bacteroidetes	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
k59_591403_2	1041930.Mtc_1428	2.03e-29	108.0	arCOG07749@1|root,arCOG07749@2157|Archaea,2Y5CW@28890|Euryarchaeota,2NB92@224756|Methanomicrobia	224756|Methanomicrobia	S	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
k59_591403_3	1158294.JOMI01000007_gene517	3.77e-08	52.4	COG0614@1|root,COG0614@2|Bacteria,4NQQ6@976|Bacteroidetes,2FTW1@200643|Bacteroidia	976|Bacteroidetes	P	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
k59_982992_2	1128421.JAGA01000002_gene905	2.73e-21	95.1	COG2230@1|root,COG2230@2|Bacteria	2|Bacteria	M	cyclopropane-fatty-acyl-phospholipid synthase	-	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	iAF987.Gmet_2187	CMAS
k59_1593373_1	1457250.BBMO01000002_gene2310	2.48e-05	51.6	COG0419@1|root,arCOG00368@2157|Archaea	2157|Archaea	L	Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50 Mre11 complex	-	-	-	-	-	-	-	-	-	-	-	-	MMPL,PQQ_2,Peptidase_S74,Pkinase
k59_201506_2	118163.Ple7327_2774	2.31e-25	97.8	COG2963@1|root,COG2963@2|Bacteria,1GAKB@1117|Cyanobacteria	1117|Cyanobacteria	L	IMG reference gene	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
k59_315291_1	1521187.JPIM01000008_gene2107	3.66e-79	257.0	COG1449@1|root,COG1449@2|Bacteria,2G5XB@200795|Chloroflexi,3768X@32061|Chloroflexia	32061|Chloroflexia	G	Belongs to the glycosyl hydrolase 57 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF3536,Glyco_hydro_57
k59_645945_1	479434.Sthe_1576	2.65e-37	137.0	COG5282@1|root,COG5282@2|Bacteria,2G800@200795|Chloroflexi,27XTJ@189775|Thermomicrobia	189775|Thermomicrobia	S	Zincin-like metallopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Zincin_2
k59_1425885_1	945713.IALB_3198	1.43e-109	329.0	COG0534@1|root,COG0534@2|Bacteria	2|Bacteria	V	drug transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	MatE
k59_483142_1	494419.ALPM01000089_gene558	2.09e-38	146.0	COG0702@1|root,COG0702@2|Bacteria,2GIZA@201174|Actinobacteria,1W815@1268|Micrococcaceae	201174|Actinobacteria	GM	Protein of unknown function (DUF2867)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2867,NAD_binding_10,TspO_MBR
k59_869346_1	886293.Sinac_2843	5.43e-65	220.0	COG1680@1|root,COG2173@1|root,COG1680@2|Bacteria,COG2173@2|Bacteria,2IWSU@203682|Planctomycetes	203682|Planctomycetes	MV	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,Peptidase_M15
k59_483166_1	1121035.AUCH01000004_gene310	7.75e-11	68.2	COG2114@1|root,COG3629@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3629@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria	1224|Proteobacteria	T	Adenylate Guanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,Guanylate_cyc
k59_1757992_1	1265505.ATUG01000001_gene3189	2.08e-95	292.0	COG5598@1|root,COG5598@2|Bacteria,1MWJN@1224|Proteobacteria,42Q8R@68525|delta/epsilon subdivisions,2WMDK@28221|Deltaproteobacteria,2MJEG@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Trimethylamine methyltransferase	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
k59_37237_1	1123237.Salmuc_04608	2.03e-55	189.0	COG0179@1|root,COG0179@2|Bacteria,1MVFA@1224|Proteobacteria,2TRTM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG0179 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)	-	-	3.7.1.20	ko:K16165	ko00350,ko01100,ko01120,map00350,map01100,map01120	-	R01085	RC00326,RC00446	ko00000,ko00001,ko01000	-	-	-	FAA_hydrolase
k59_1538306_1	926569.ANT_23610	5.6e-141	410.0	COG0172@1|root,COG0172@2|Bacteria,2G5PD@200795|Chloroflexi	200795|Chloroflexi	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
k59_1318299_1	316274.Haur_3212	1.22e-11	67.4	COG1008@1|root,COG1008@2|Bacteria,2G5VU@200795|Chloroflexi,3757Y@32061|Chloroflexia	32061|Chloroflexia	C	TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_1318299_2	1123367.C666_03415	2.93e-06	50.1	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,2VJ2J@28216|Betaproteobacteria,2KUJW@206389|Rhodocyclales	206389|Rhodocyclales	CP	COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit	nuoL	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
k59_1484251_1	1207063.P24_03650	1.35e-14	73.9	COG2318@1|root,COG2318@2|Bacteria,1RD3M@1224|Proteobacteria,2U8HG@28211|Alphaproteobacteria,2JT7M@204441|Rhodospirillales	204441|Rhodospirillales	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB
k59_1484259_1	639283.Snov_0193	3.85e-54	182.0	COG0673@1|root,COG0673@2|Bacteria,1PGGT@1224|Proteobacteria,2V8DP@28211|Alphaproteobacteria,3F24I@335928|Xanthobacteraceae	28211|Alphaproteobacteria	E	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_871249_1	379066.GAU_2382	8.63e-67	214.0	COG1013@1|root,COG1013@2|Bacteria,1ZSWT@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
k59_203347_1	1125863.JAFN01000001_gene418	6.84e-52	179.0	COG5598@1|root,COG5598@2|Bacteria,1MWJN@1224|Proteobacteria,42N1X@68525|delta/epsilon subdivisions,2WKMS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Trimethylamine methyltransferase MttB (TMA methyltransferase)	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
k59_1707730_1	1267535.KB906767_gene5529	1.9e-66	213.0	COG0079@1|root,COG0079@2|Bacteria,3Y3M6@57723|Acidobacteria,2JIS3@204432|Acidobacteriia	204432|Acidobacteriia	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_593331_1	644076.SCH4B_2104	8.88e-55	191.0	COG0457@1|root,COG0457@2|Bacteria,1N01S@1224|Proteobacteria,2TSR4@28211|Alphaproteobacteria,4NBIG@97050|Ruegeria	28211|Alphaproteobacteria	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1094811_1	997346.HMPREF9374_1651	6.83e-25	111.0	COG1074@1|root,COG1074@2|Bacteria,1TQ35@1239|Firmicutes,4HA64@91061|Bacilli,27CSD@186824|Thermoactinomycetaceae	91061|Bacilli	L	PD-(D/E)XK nuclease superfamily	-	-	3.6.4.12	ko:K16898	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
k59_1595303_1	696281.Desru_2646	2.37e-07	57.8	COG0277@1|root,COG0277@2|Bacteria,1TPBC@1239|Firmicutes,24A99@186801|Clostridia,260J4@186807|Peptococcaceae	186801|Clostridia	C	FAD linked oxidases, C-terminal domain	glcD	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_1427822_1	1459636.NTE_02637	1.88e-53	178.0	COG1405@1|root,arCOG01981@2157|Archaea,41SXZ@651137|Thaumarchaeota	2157|Archaea	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfb	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
k59_816261_1	65093.PCC7418_3612	7.14e-43	153.0	COG2821@1|root,COG2821@2|Bacteria,1G0DA@1117|Cyanobacteria	1117|Cyanobacteria	M	Membrane-bound lytic murein transglycosylase	mltA	-	-	ko:K08304	-	-	-	-	ko00000,ko01000,ko01011	-	GH102	-	3D,MltA
k59_484959_2	926569.ANT_09930	3.35e-36	135.0	COG1300@1|root,COG1668@1|root,COG1300@2|Bacteria,COG1668@2|Bacteria,2G8CN@200795|Chloroflexi	200795|Chloroflexi	CP	Stage II sporulation protein M	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane,ABC2_membrane_2,SpoIIM
k59_317286_1	1266998.ATUJ01000008_gene465	2.08e-72	223.0	COG0052@1|root,COG0052@2|Bacteria,1MU33@1224|Proteobacteria,2TRXE@28211|Alphaproteobacteria,2PUE1@265|Paracoccus	28211|Alphaproteobacteria	J	Belongs to the universal ribosomal protein uS2 family	rpsB	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
k59_1041195_1	1304885.AUEY01000045_gene251	6.54e-10	67.0	COG3322@1|root,COG4585@1|root,COG3322@2|Bacteria,COG4585@2|Bacteria,1MWPN@1224|Proteobacteria,42RUN@68525|delta/epsilon subdivisions,2WMXF@28221|Deltaproteobacteria,2MJMS@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	CHASE4,HATPase_c,HisKA_3
k59_930410_1	330214.NIDE3764	1.62e-101	301.0	28PNA@1|root,2ZCB3@2|Bacteria	2|Bacteria	S	Transglycosylase SLT domain	-	-	-	-	-	-	-	-	-	-	-	-	SLT
k59_706338_1	1238450.VIBNISOn1_1190004	3.96e-19	83.6	2C88J@1|root,33I1N@2|Bacteria,1NPA7@1224|Proteobacteria,1SSPB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Antitermination protein Q	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_484992_1	717785.HYPMC_1685	1.25e-09	61.2	COG2863@1|root,COG2863@2|Bacteria,1N7W9@1224|Proteobacteria	1224|Proteobacteria	C	cytochrome	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
k59_930428_2	706587.Desti_1048	5.29e-46	157.0	COG0861@1|root,COG0861@2|Bacteria,1MWC9@1224|Proteobacteria,42MZB@68525|delta/epsilon subdivisions,2WKV4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM Integral membrane protein TerC	-	-	-	-	-	-	-	-	-	-	-	-	TerC
k59_984930_1	1443111.JASG01000004_gene560	1.35e-29	117.0	COG4325@1|root,COG4325@2|Bacteria,1MXTM@1224|Proteobacteria,2TRWI@28211|Alphaproteobacteria,3ZX3M@60136|Sulfitobacter	28211|Alphaproteobacteria	S	Predicted membrane protein (DUF2254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2254
k59_706368_1	1123508.JH636447_gene7958	5.96e-11	64.3	COG4191@1|root,COG4191@2|Bacteria	1123508.JH636447_gene7958|-	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_706368_2	1128421.JAGA01000004_gene2489	5.75e-40	142.0	COG2141@1|root,COG2141@2|Bacteria,2NQKB@2323|unclassified Bacteria	2|Bacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_1759851_1	454957.IA64_17450	3.13e-43	145.0	COG0314@1|root,COG0314@2|Bacteria,1RGUX@1224|Proteobacteria,1SA8G@1236|Gammaproteobacteria,1XC86@135614|Xanthomonadales	135614|Xanthomonadales	H	Molybdopterin-converting factor chain 2	moaE	-	2.8.1.12	ko:K03635	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE
k59_706385_1	1463857.JOFZ01000011_gene2254	4.34e-34	132.0	COG2755@1|root,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
k59_1205467_1	1197477.IA57_08910	7.35e-103	318.0	COG3968@1|root,COG3968@2|Bacteria,4NG2B@976|Bacteroidetes,1HWKZ@117743|Flavobacteriia	976|Bacteroidetes	S	glutamine synthetase	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	GSIII_N,Gln-synt_C
k59_706386_1	1123368.AUIS01000007_gene2809	3.48e-68	222.0	COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,1RPZC@1236|Gammaproteobacteria,2NBT2@225057|Acidithiobacillales	225057|Acidithiobacillales	J	Beta-Casp domain	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,RMMBL
k59_1427916_2	331869.BAL199_08648	1.39e-07	52.0	COG0111@1|root,COG0111@2|Bacteria,1MW1U@1224|Proteobacteria,2TSUU@28211|Alphaproteobacteria,4BPZ3@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	EH	dehydrogenase and related dehydrogenases	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_259461_1	1134474.O59_003197	2.16e-63	208.0	COG3975@1|root,COG3975@2|Bacteria,1QX25@1224|Proteobacteria,1RWD8@1236|Gammaproteobacteria,1FGTQ@10|Cellvibrio	1236|Gammaproteobacteria	S	protease with the C-terminal PDZ domain	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_538408_1	665942.HMPREF1022_01949	2.46e-36	135.0	COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,42QM6@68525|delta/epsilon subdivisions,2WJ8G@28221|Deltaproteobacteria,2M7Y8@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Glycine cleavage system T protein	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
k59_1041266_1	1307759.JOMJ01000004_gene2877	1.02e-40	149.0	COG1252@1|root,COG1252@2|Bacteria,1MX96@1224|Proteobacteria,42PFG@68525|delta/epsilon subdivisions,2WKPM@28221|Deltaproteobacteria,2MA22@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	pyridine nucleotide-disulfide oxidoreductase	ndh2	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_1484386_1	502025.Hoch_1857	5.31e-14	76.6	COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,43BQE@68525|delta/epsilon subdivisions,2X71H@28221|Deltaproteobacteria,2YX6T@29|Myxococcales	28221|Deltaproteobacteria	I	Biotin carboxylase C-terminal domain	-	-	6.4.1.4,6.4.1.5	ko:K01968,ko:K13777	ko00280,ko00281,ko01100,map00280,map00281,map01100	M00036	R03494,R04138	RC00367,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
k59_930481_1	269797.Mbar_A3573	2.64e-17	80.5	COG1131@1|root,arCOG00194@2157|Archaea,2XUK9@28890|Euryarchaeota,2N95K@224756|Methanomicrobia	224756|Methanomicrobia	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
k59_390407_2	1121924.ATWH01000014_gene3439	1.53e-16	77.8	COG0824@1|root,COG0824@2|Bacteria,2IHBJ@201174|Actinobacteria,4FNDN@85023|Microbacteriaceae	201174|Actinobacteria	S	Thioesterase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT_2
k59_1057511_1	639283.Snov_3913	9.68e-23	99.0	COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,2TV4H@28211|Alphaproteobacteria,3EZ9H@335928|Xanthobacteraceae	28211|Alphaproteobacteria	M	HlyD family secretion protein	macA	-	-	ko:K02005,ko:K13888	-	M00709	-	-	ko00000,ko00002,ko02000	8.A.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
k59_1168711_1	1278073.MYSTI_06326	4.51e-29	120.0	COG1215@1|root,COG1215@2|Bacteria,1MX08@1224|Proteobacteria,42MS6@68525|delta/epsilon subdivisions,2WIYE@28221|Deltaproteobacteria,2YUMA@29|Myxococcales	28221|Deltaproteobacteria	M	Glycosyl transferase family 21	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
k59_724023_1	83406.HDN1F_09550	3.19e-34	130.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,1S0WV@1236|Gammaproteobacteria,1J5KF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases	korA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
k59_724023_2	420324.KI911965_gene410	2.34e-34	131.0	COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,2TSE2@28211|Alphaproteobacteria,1JRT6@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	TIGRFAM glutamate synthase, NADH NADPH, small subunit	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_20,Pyr_redox_2
k59_446025_1	857087.Metme_1869	2.8e-50	178.0	COG0577@1|root,COG1136@1|root,COG0577@2|Bacteria,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,1RNUJ@1236|Gammaproteobacteria,1XEX2@135618|Methylococcales	135618|Methylococcales	V	Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides	macB	-	-	ko:K05685	ko02010,map02010	M00709	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.122.1,3.A.1.122.12	-	-	ABC_tran,FtsX,MacB_PCD
k59_1391107_1	1150599.MPHLEI_16186	2.05e-10	65.5	COG2159@1|root,COG2159@2|Bacteria,2GKG2@201174|Actinobacteria,235UJ@1762|Mycobacteriaceae	201174|Actinobacteria	S	metal-dependent hydrolase of the TIM-barrel fold	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
k59_1391120_1	483219.LILAB_20260	2.93e-43	152.0	COG1475@1|root,COG1475@2|Bacteria,1Q2AH@1224|Proteobacteria,437X8@68525|delta/epsilon subdivisions,2X9QN@28221|Deltaproteobacteria,2YUMN@29|Myxococcales	28221|Deltaproteobacteria	K	ParB-like nuclease domain	-	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
k59_279168_1	1027273.GZ77_11570	7.26e-92	291.0	COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,1RP14@1236|Gammaproteobacteria,1XHWN@135619|Oceanospirillales	135619|Oceanospirillales	J	due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
k59_1113235_2	883114.HMPREF9709_00913	0.000962	45.1	COG1525@1|root,COG1525@2|Bacteria,1V3MZ@1239|Firmicutes,25BQY@186801|Clostridia	186801|Clostridia	L	Staphylococcal nuclease homologues	nucH	-	3.1.31.1	ko:K01174	-	-	-	-	ko00000,ko01000	-	-	-	SNase
k59_1669087_1	522772.Dacet_2392	1.45e-28	120.0	COG0210@1|root,COG0210@2|Bacteria,2GF1V@200930|Deferribacteres	200930|Deferribacteres	L	UvrD-like helicase C-terminal domain	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_112430_1	671143.DAMO_0673	3.38e-98	292.0	COG0528@1|root,COG0528@2|Bacteria,2NNRY@2323|unclassified Bacteria	2|Bacteria	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006225,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009163,GO:0009165,GO:0009185,GO:0009188,GO:0009193,GO:0009194,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0033862,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042455,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046048,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046872,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	iSB619.SA_RS06240	AA_kinase
k59_390444_1	344747.PM8797T_25281	1.04e-58	199.0	COG2072@1|root,COG2072@2|Bacteria	2|Bacteria	P	N,N-dimethylaniline monooxygenase activity	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4873,FMO-like,HI0933_like,Pyr_redox_2,Pyr_redox_3
k59_501588_1	290402.Cbei_1093	0.000608	46.2	COG3385@1|root,COG3385@2|Bacteria,1UNGW@1239|Firmicutes,24BMP@186801|Clostridia,36GYZ@31979|Clostridiaceae	186801|Clostridia	L	PFAM Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5,DDE_Tnp_1
k59_1446804_1	1379270.AUXF01000002_gene1717	6.64e-31	125.0	COG5001@1|root,COG5001@2|Bacteria,1ZT12@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS
k59_890826_1	269799.Gmet_2619	2.37e-22	99.8	COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,42M0J@68525|delta/epsilon subdivisions,2WK1D@28221|Deltaproteobacteria,43TGS@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
k59_1613464_1	1121440.AUMA01000003_gene3140	1.38e-48	170.0	COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,42N81@68525|delta/epsilon subdivisions,2WJB0@28221|Deltaproteobacteria,2M97P@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
k59_890832_1	926550.CLDAP_04870	5.42e-36	139.0	COG2133@1|root,COG2133@2|Bacteria,2G62S@200795|Chloroflexi	200795|Chloroflexi	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
k59_1613469_1	350688.Clos_1614	1.61e-09	57.4	COG1302@1|root,COG1302@2|Bacteria,1V4IC@1239|Firmicutes,24JNM@186801|Clostridia,36KNG@31979|Clostridiaceae	186801|Clostridia	S	Alkaline shock protein	asp	-	-	-	-	-	-	-	-	-	-	-	Asp23
k59_1613469_2	552811.Dehly_0304	6.54e-31	115.0	COG0781@1|root,COG0781@2|Bacteria,2G6XA@200795|Chloroflexi,34CUC@301297|Dehalococcoidia	301297|Dehalococcoidia	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
k59_1002015_1	1318628.MARLIPOL_15884	3e-38	136.0	COG1309@1|root,COG1309@2|Bacteria,1RBV0@1224|Proteobacteria	1224|Proteobacteria	K	COG1309 Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_1724697_1	926569.ANT_08370	1.81e-51	168.0	COG1143@1|root,COG1143@2|Bacteria,2G6P8@200795|Chloroflexi	200795|Chloroflexi	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	-	1.6.5.3	ko:K00338,ko:K05580	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
k59_446088_1	293826.Amet_0164	4.24e-22	95.5	COG1694@1|root,COG3956@2|Bacteria,1TPK1@1239|Firmicutes,247XM@186801|Clostridia,36E9N@31979|Clostridiaceae	186801|Clostridia	S	MazG family	mazG	-	3.6.1.66	ko:K02428,ko:K02499	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000,ko03036	-	-	-	MazG,TP_methylase
k59_1168781_1	1379698.RBG1_1C00001G0777	2.74e-49	177.0	COG2864@1|root,COG2864@2|Bacteria,2NQFM@2323|unclassified Bacteria	2|Bacteria	P	Prokaryotic cytochrome b561	cbcY	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_c3_2,Cytochrome_C7,Ni_hydr_CYTB,Paired_CXXCH_1,Rhodanese
k59_1724704_1	1244869.H261_17328	5.43e-61	202.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2TRN7@28211|Alphaproteobacteria,2JQ3A@204441|Rhodospirillales	204441|Rhodospirillales	C	COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes	lpd	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim
k59_1613494_1	296591.Bpro_0197	5.99e-63	205.0	COG1893@1|root,COG1893@2|Bacteria,1MVZ1@1224|Proteobacteria,2VJFW@28216|Betaproteobacteria,4A9R6@80864|Comamonadaceae	28216|Betaproteobacteria	H	Ketopantoate reductase	panE	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
k59_946443_2	1038869.AXAN01000015_gene3058	0.00023	45.1	COG2423@1|root,COG2423@2|Bacteria,1N3EI@1224|Proteobacteria,2VT4N@28216|Betaproteobacteria,1KGVW@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Ectoine utilization protein EutC	-	-	4.3.1.12	ko:K01750	ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230	-	R00671	RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
k59_1168804_1	926569.ANT_20890	1.16e-90	283.0	COG0465@1|root,COG0465@2|Bacteria,2G5J3@200795|Chloroflexi	200795|Chloroflexi	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_1113314_2	696281.Desru_3272	3.8e-22	99.0	COG0608@1|root,COG0608@2|Bacteria,1TPXE@1239|Firmicutes,247NU@186801|Clostridia,25ZYA@186807|Peptococcaceae	186801|Clostridia	L	TIGRFAM single-stranded-DNA-specific exonuclease RecJ	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1,Helicase_C
k59_279236_1	314230.DSM3645_17570	8.97e-23	99.8	COG0500@1|root,COG4797@1|root,COG0500@2|Bacteria,COG4797@2|Bacteria,2IX32@203682|Planctomycetes	203682|Planctomycetes	Q	Predicted methyltransferase regulatory domain	-	-	-	-	-	-	-	-	-	-	-	-	MethyTransf_Reg,Methyltransf_25,Methyltransf_31
k59_279236_2	1504672.669787505	7.52e-11	60.5	2CMCS@1|root,32SEB@2|Bacteria,1N3SA@1224|Proteobacteria,2VTVV@28216|Betaproteobacteria,4AFRC@80864|Comamonadaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1669156_1	402881.Plav_2531	1.17e-69	235.0	COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,2TRUB@28211|Alphaproteobacteria,1JNNX@119043|Rhodobiaceae	28211|Alphaproteobacteria	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	2.7.7.7	ko:K02337,ko:K14162	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_501667_1	1347368.HG964403_gene4517	8.23e-15	72.0	COG1670@1|root,COG1670@2|Bacteria,1VI3V@1239|Firmicutes,4HV5Y@91061|Bacilli,1ZS67@1386|Bacillus	91061|Bacilli	J	Acetyltransferase (GNAT) domain	-	-	2.3.1.57	ko:K00657	ko00330,ko01100,ko04216,map00330,map01100,map04216	M00135	R01154	RC00004,RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1
k59_1280041_1	1237149.C900_03986	1.93e-20	95.5	COG3292@1|root,COG4251@1|root,COG3292@2|Bacteria,COG4251@2|Bacteria,4NK8Q@976|Bacteroidetes	976|Bacteroidetes	T	Two component regulator propeller	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HTH_18,HisKA,HisKA_2,Reg_prop,Response_reg,SpoIIE,Y_Y_Y
k59_334864_1	323850.Shew_1958	3.91e-55	181.0	COG0284@1|root,COG0284@2|Bacteria,1MW2C@1224|Proteobacteria,1RNJR@1236|Gammaproteobacteria,2Q98N@267890|Shewanellaceae	1236|Gammaproteobacteria	F	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)	pyrF	GO:0003674,GO:0003824,GO:0004590,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	iECO103_1326.ECO103_1444,iECSF_1327.ECSF_1264,iSFV_1184.SFV_1294,iSF_1195.SF1285,iSFxv_1172.SFxv_1457,iS_1188.S1368,ic_1306.c1750	OMPdecase
k59_1613529_1	649747.HMPREF0083_02687	6.72e-71	227.0	COG0304@1|root,COG0304@2|Bacteria,1TPA7@1239|Firmicutes,4H9SD@91061|Bacilli,26QJA@186822|Paenibacillaceae	91061|Bacilli	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF3	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_1224532_1	1122132.AQYH01000010_gene4050	2.59e-32	129.0	2C14K@1|root,32R84@2|Bacteria,1MYN0@1224|Proteobacteria,2U03I@28211|Alphaproteobacteria,4BB5J@82115|Rhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1558008_1	1122216.AUHW01000013_gene974	1.07e-51	182.0	COG1200@1|root,COG1200@2|Bacteria,1TQ6I@1239|Firmicutes,4H27E@909932|Negativicutes	909932|Negativicutes	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
k59_835266_1	1151117.AJLF01000001_gene1678	1.38e-24	95.5	arCOG03655@1|root,arCOG03655@2157|Archaea,2Y3XR@28890|Euryarchaeota,244IA@183968|Thermococci	183968|Thermococci	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_835266_2	1121396.KB892902_gene2335	1.84e-18	85.5	COG0003@1|root,COG0003@2|Bacteria,1MUTX@1224|Proteobacteria,42V9Y@68525|delta/epsilon subdivisions,2WND5@28221|Deltaproteobacteria,2MQ2B@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Anion-transporting ATPase	arsA	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase
k59_1224538_1	498761.HM1_1293	4.35e-68	229.0	COG0556@1|root,COG0556@2|Bacteria,1TPKB@1239|Firmicutes,247P7@186801|Clostridia	186801|Clostridia	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
k59_1168846_1	882.DVU_1851	2.27e-55	188.0	COG0739@1|root,COG0739@2|Bacteria,1NESH@1224|Proteobacteria,42MGB@68525|delta/epsilon subdivisions,2WJ7F@28221|Deltaproteobacteria,2M7ZK@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	PFAM Peptidase M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_446161_1	1415756.JQMY01000005_gene97	2.02e-100	303.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TSGZ@28211|Alphaproteobacteria,2PFSQ@252301|Oceanicola	28211|Alphaproteobacteria	L	Transposase IS116/IS110/IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_890925_1	251229.Chro_2593	4.02e-76	236.0	COG1131@1|root,COG1131@2|Bacteria,1GDU7@1117|Cyanobacteria	1117|Cyanobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_781615_2	709797.CSIRO_3908	0.00047	41.6	COG0620@1|root,COG0620@2|Bacteria,1MV2Z@1224|Proteobacteria,2TSRH@28211|Alphaproteobacteria,3JTC4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Cobalamin-independent synthase, Catalytic domain	MA20_07800	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
k59_448162_1	671143.DAMO_1670	1.01e-96	290.0	COG1290@1|root,COG1290@2|Bacteria	2|Bacteria	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_B_C
k59_1059509_1	946077.W5A_03214	2.14e-99	317.0	COG1197@1|root,COG1197@2|Bacteria,4NEPA@976|Bacteroidetes,1HWS4@117743|Flavobacteriia	976|Bacteroidetes	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_392488_1	1229780.BN381_10199	5.28e-32	130.0	COG5617@1|root,COG5617@2|Bacteria,2H32H@201174|Actinobacteria	201174|Actinobacteria	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_726163_1	110319.CF8_2443	1.74e-85	280.0	COG3227@1|root,COG4412@1|root,COG3227@2|Bacteria,COG4412@2|Bacteria,2GJEW@201174|Actinobacteria	201174|Actinobacteria	E	Peptidase M4	-	-	-	-	-	-	-	-	-	-	-	-	FTP,PA,Peptidase_M4,Peptidase_M4_C
k59_448169_1	635013.TherJR_2208	3.24e-14	67.4	COG0695@1|root,COG0695@2|Bacteria,1VI6J@1239|Firmicutes,24QNT@186801|Clostridia,26396@186807|Peptococcaceae	186801|Clostridia	O	manually curated	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
k59_170096_1	1121033.AUCF01000001_gene2325	1.33e-55	186.0	COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,2TRQE@28211|Alphaproteobacteria,2JPC1@204441|Rhodospirillales	204441|Rhodospirillales	LU	Rossmann fold nucleotide-binding protein involved in DNA uptake	dprA	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
k59_1393017_1	1313301.AUGC01000001_gene1568	1.22e-23	106.0	COG3975@1|root,COG3975@2|Bacteria,4NGTY@976|Bacteroidetes	976|Bacteroidetes	S	protease with the C-terminal PDZ domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M61
k59_1726698_1	1122247.C731_3748	1.62e-21	96.3	COG0152@1|root,COG0152@2|Bacteria,2GK3H@201174|Actinobacteria,232AS@1762|Mycobacteriaceae	201174|Actinobacteria	F	Belongs to the SAICAR synthetase family	purC	GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.6,6.3.4.13	ko:K01923,ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144,R04591	RC00064,RC00090,RC00162,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
k59_726186_1	926569.ANT_12400	1.78e-113	335.0	COG0002@1|root,COG0002@2|Bacteria,2G5W0@200795|Chloroflexi	200795|Chloroflexi	E	Catalyzes the NADPH-dependent reduction of LysW - aminoadipate 6-phosphate to yield LysW -aminoadipate 6- semialdehyde	lysY	-	-	ko:K05829	ko00220,ko00300,ko01100,ko01110,ko01210,ko01230,map00220,map00300,map01100,map01110,map01210,map01230	M00031,M00763	R09777,R10931	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
k59_892959_1	1115632.JAFW01000001_gene2087	1.5e-65	209.0	COG0388@1|root,COG0388@2|Bacteria,2GP6F@201174|Actinobacteria,1WC5I@1268|Micrococcaceae	201174|Actinobacteria	S	Carbon-nitrogen hydrolase	-	-	3.5.1.49	ko:K01455	ko00460,ko00630,ko00910,ko01200,map00460,map00630,map00910,map01200	-	R00524	RC02432,RC02810	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
k59_1726711_2	479434.Sthe_0606	2.52e-73	227.0	COG2057@1|root,COG2057@2|Bacteria,2G6MS@200795|Chloroflexi	200795|Chloroflexi	I	Coenzyme A transferase	-	-	2.8.3.12	ko:K01040	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
k59_837154_1	983548.Krodi_0874	2.7e-45	163.0	COG0166@1|root,COG0166@2|Bacteria,4NDV0@976|Bacteroidetes,1HXFR@117743|Flavobacteriia,37EFC@326319|Dokdonia	976|Bacteroidetes	G	Phosphoglucose isomerase	pgi	-	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
k59_1282041_2	861299.J421_0599	9.75e-29	111.0	COG1273@1|root,COG1273@2|Bacteria	2|Bacteria	M	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD	ku	GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0097159,GO:1901363	-	ko:K10979	ko03450,map03450	-	-	-	ko00000,ko00001,ko03400	-	-	-	Ku
k59_1337618_1	351348.Maqu_1656	4.85e-56	185.0	COG0726@1|root,COG0726@2|Bacteria,1MWMZ@1224|Proteobacteria,1RREJ@1236|Gammaproteobacteria,4663C@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	xylanase chitin deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	DUF3473,Polysacc_deac_1
k59_1448944_1	479434.Sthe_1092	3.14e-100	319.0	COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,2G86T@200795|Chloroflexi,27XQK@189775|Thermomicrobia	189775|Thermomicrobia	G	Alpha-amylase domain	-	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	APH,Alpha-amylase,Malt_amylase_C
k59_1337626_1	314231.FP2506_18579	6.37e-24	101.0	COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,2TRTP@28211|Alphaproteobacteria,2PJ5W@255475|Aurantimonadaceae	28211|Alphaproteobacteria	O	HflC and HflK could encode or regulate a protease	hflK	-	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7,HflK_N
k59_1337626_2	555779.Dthio_PD1795	2.06e-06	50.1	COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,42N2V@68525|delta/epsilon subdivisions,2WIPS@28221|Deltaproteobacteria,2M7XX@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	HflC and HflK could regulate a protease	hflC	-	-	ko:K04087	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
k59_1726723_1	4096.XP_009757611.1	4.83e-05	45.4	COG0667@1|root,KOG1575@2759|Eukaryota,37JT5@33090|Viridiplantae,3GFD9@35493|Streptophyta,44FU8@71274|asterids	35493|Streptophyta	C	Aldo/keto reductase family	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009526,GO:0009532,GO:0009534,GO:0009535,GO:0009536,GO:0009570,GO:0009579,GO:0009941,GO:0010287,GO:0016020,GO:0031967,GO:0031975,GO:0031976,GO:0031984,GO:0034357,GO:0042651,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044436,GO:0044444,GO:0044446,GO:0044464,GO:0055035	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_3482_1	868864.Dester_0702	4.06e-32	126.0	COG4956@1|root,COG4956@2|Bacteria,2G4G6@200783|Aquificae	200783|Aquificae	S	SMART Nucleotide binding protein, PINc	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_670561_2	1122143.AUEG01000010_gene1157	9.54e-28	104.0	2DMDR@1|root,32QSY@2|Bacteria,1V941@1239|Firmicutes,4HJJU@91061|Bacilli,27GHV@186828|Carnobacteriaceae	91061|Bacilli	S	Protein of unknown function (DUF1475)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1475
k59_336752_1	502025.Hoch_3971	2.23e-08	57.8	COG2825@1|root,COG2825@2|Bacteria,1MZVJ@1224|Proteobacteria,42VH3@68525|delta/epsilon subdivisions,2WP6K@28221|Deltaproteobacteria,2YVZ7@29|Myxococcales	28221|Deltaproteobacteria	M	Outer membrane protein (OmpH-like)	-	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
k59_503768_1	1183438.GKIL_0852	1.98e-28	119.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	CsgG,TPR_16
k59_726229_1	357808.RoseRS_4613	1.99e-31	125.0	COG0318@1|root,COG0318@2|Bacteria,2G5K4@200795|Chloroflexi,3758A@32061|Chloroflexia	32061|Chloroflexia	IQ	PFAM AMP-dependent synthetase and ligase	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_1520160_1	1380394.JADL01000003_gene5228	7.41e-69	222.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,2TQYP@28211|Alphaproteobacteria,2JQRC@204441|Rhodospirillales	204441|Rhodospirillales	E	Cys/Met metabolism PLP-dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
k59_408566_1	479434.Sthe_0743	1.38e-05	53.1	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,2G5Q5@200795|Chloroflexi,27Y10@189775|Thermomicrobia	200795|Chloroflexi	EU	PFAM peptidase S9 prolyl oligopeptidase active site domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
k59_352244_1	477974.Daud_1728	4.17e-41	151.0	COG2202@1|root,COG2203@1|root,COG3437@1|root,COG3605@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3437@2|Bacteria,COG3605@2|Bacteria,1UQJH@1239|Firmicutes,248UM@186801|Clostridia,261WQ@186807|Peptococcaceae	186801|Clostridia	T	HD domain	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	GAF_2,HD,HD_5
k59_797871_1	1282360.ABAC460_07145	4.9e-42	154.0	28VPU@1|root,2ZHRS@2|Bacteria,1R7QU@1224|Proteobacteria,2U49X@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_742300_1	880073.Calab_1318	6.41e-46	162.0	COG0508@1|root,COG0508@2|Bacteria,2NP69@2323|unclassified Bacteria	2|Bacteria	C	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)	aceF	GO:0003674,GO:0003824,GO:0004742,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006139,GO:0006163,GO:0006164,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008289,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016407,GO:0016417,GO:0016418,GO:0016740,GO:0016746,GO:0016747,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030523,GO:0031405,GO:0031406,GO:0032787,GO:0032991,GO:0033293,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045254,GO:0046390,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681,GO:1902494,GO:1990204	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iETEC_1333.ETEC_0111,iSSON_1240.SSON_0123,iYL1228.KPN_00119	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_852330_1	290397.Adeh_2000	4.36e-05	51.6	COG0501@1|root,COG0501@2|Bacteria	2|Bacteria	O	metalloendopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48,Peptidase_M56
k59_742314_1	502558.EGYY_21810	2.19e-17	80.9	COG0736@1|root,COG0736@2|Bacteria,2HT7V@201174|Actinobacteria,4CVSA@84998|Coriobacteriia	84998|Coriobacteriia	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
k59_742314_2	762983.HMPREF9444_01142	5.4e-24	98.2	COG0854@1|root,COG0854@2|Bacteria,1MU9W@1224|Proteobacteria,1RMS5@1236|Gammaproteobacteria,1Y3DZ@135624|Aeromonadales	135624|Aeromonadales	H	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate	pdxJ	-	2.6.99.2	ko:K03474	ko00750,ko01100,map00750,map01100	M00124	R05838	RC01476	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxJ
k59_241735_1	1121104.AQXH01000001_gene1386	2.12e-43	160.0	COG2091@1|root,COG2091@2|Bacteria,4NGXG@976|Bacteroidetes	976|Bacteroidetes	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
k59_687125_1	1211579.PP4_31050	4.24e-71	236.0	COG0457@1|root,COG1413@1|root,COG0457@2|Bacteria,COG1413@2|Bacteria,1MX2U@1224|Proteobacteria,1RPD2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C552,Cytochrome_C554,HEAT_2,Paired_CXXCH_1,TPR_11,TPR_16,TPR_19,TPR_8
k59_185774_1	1267533.KB906738_gene2060	4.68e-21	91.7	COG4960@1|root,COG4960@2|Bacteria,3Y57D@57723|Acidobacteria,2JJT1@204432|Acidobacteriia	204432|Acidobacteriia	OU	Type IV leader peptidase family	-	-	3.4.23.43	ko:K02278	-	-	-	-	ko00000,ko01000,ko02035,ko02044	-	-	-	Peptidase_A24
k59_1186772_1	935840.JAEQ01000002_gene3306	3.5e-84	258.0	COG2857@1|root,COG2857@2|Bacteria,1QFU2@1224|Proteobacteria,2TUHX@28211|Alphaproteobacteria,43HNB@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	Cytochrome C1	petC	-	-	ko:K00413	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrom_C1
k59_797903_1	935836.JAEL01000140_gene636	5.93e-83	258.0	COG2224@1|root,COG2224@2|Bacteria,1TP1U@1239|Firmicutes,4HBBD@91061|Bacilli,1ZBPW@1386|Bacillus	91061|Bacilli	C	Isocitrate lyase	aceA	-	4.1.3.1	ko:K01637	ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200	M00012	R00479	RC00311,RC00313	ko00000,ko00001,ko00002,ko01000	-	-	-	ICL
k59_1244022_1	596154.Alide2_1844	3.96e-24	106.0	COG1960@1|root,COG1960@2|Bacteria,1MVJC@1224|Proteobacteria,2VMR3@28216|Betaproteobacteria,4AD85@80864|Comamonadaceae	28216|Betaproteobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_1244022_2	86049.XP_008723431.1	2.1e-05	45.8	COG1804@1|root,KOG3957@2759|Eukaryota,38CWZ@33154|Opisthokonta,3NU4P@4751|Fungi,3QSHV@4890|Ascomycota,20KNE@147545|Eurotiomycetes,3MVTD@451870|Chaetothyriomycetidae	4751|Fungi	I	CoA-transferase family III	-	-	2.8.3.13	ko:K18703	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
k59_1687236_1	439235.Dalk_0857	8.23e-24	106.0	COG5421@1|root,COG5421@2|Bacteria,1R6MI@1224|Proteobacteria,42U8I@68525|delta/epsilon subdivisions,2WQCY@28221|Deltaproteobacteria,2MNWM@213118|Desulfobacterales	28221|Deltaproteobacteria	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_1409342_1	671143.DAMO_3015	1.37e-17	86.7	COG2844@1|root,COG2844@2|Bacteria	2|Bacteria	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	-	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,GlnD_UR_UTase,GlnE,HD,NTP_transf_2
k59_74780_1	1121422.AUMW01000022_gene1554	3.9e-17	84.0	COG0115@1|root,COG0115@2|Bacteria,1TPY2@1239|Firmicutes,25CC4@186801|Clostridia,262GR@186807|Peptococcaceae	186801|Clostridia	EH	PFAM Aminotransferase, class IV	ilvE2	-	2.6.1.42,4.1.3.38	ko:K00826,ko:K02619	ko00270,ko00280,ko00290,ko00770,ko00790,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map00790,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R05553,R10991	RC00006,RC00036,RC01843,RC02148	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
k59_1186779_1	1120973.AQXL01000069_gene3	3.55e-60	201.0	COG4799@1|root,COG4799@2|Bacteria,1TQCV@1239|Firmicutes,4HC50@91061|Bacilli,2785C@186823|Alicyclobacillaceae	91061|Bacilli	I	Carboxyl transferase domain	yqjD	GO:0003674,GO:0003824,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016421,GO:0016874,GO:0016885,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0071704,GO:0072329,GO:1901575	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_1409357_1	1089548.KI783301_gene2348	1.48e-51	169.0	COG0521@1|root,COG0521@2|Bacteria,1V3XM@1239|Firmicutes,4HH5V@91061|Bacilli,3WFMW@539002|Bacillales incertae sedis	91061|Bacilli	H	May be involved in the biosynthesis of molybdopterin	moaB	-	2.7.7.75	ko:K03638	ko00790,ko01100,map00790,map01100	-	R09726	RC00002	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth
k59_408634_2	1121403.AUCV01000038_gene4238	6.89e-39	138.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42QN5@68525|delta/epsilon subdivisions,2WMD7@28221|Deltaproteobacteria,2MJC9@213118|Desulfobacterales	28221|Deltaproteobacteria	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1075519_1	314230.DSM3645_23821	2.51e-07	55.8	COG0515@1|root,COG0515@2|Bacteria,2IXG3@203682|Planctomycetes	203682|Planctomycetes	KLT	Serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
k59_574757_2	1121430.JMLG01000002_gene1131	1.24e-24	104.0	COG0500@1|root,COG0500@2|Bacteria	2|Bacteria	Q	methyltransferase activity	-	-	2.1.1.302	ko:K21377	-	-	-	-	ko00000,ko01000	-	-	-	Dimerisation2,Methyltransf_2
k59_909915_1	1167006.UWK_03127	1.13e-59	200.0	COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,42M2G@68525|delta/epsilon subdivisions,2WJ80@28221|Deltaproteobacteria,2MIFW@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
k59_852422_1	1382306.JNIM01000001_gene4011	1.06e-17	83.2	COG0541@1|root,COG0541@2|Bacteria,2G627@200795|Chloroflexi	200795|Chloroflexi	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
k59_852422_2	1154757.Q5C_10250	6.38e-35	123.0	COG0228@1|root,COG0228@2|Bacteria,1VA0X@1239|Firmicutes,4HKNN@91061|Bacilli,4AXVF@81850|Leuconostocaceae	91061|Bacilli	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
k59_1020802_2	1123368.AUIS01000008_gene2255	1.12e-34	125.0	COG0680@1|root,COG0680@2|Bacteria,1N3AS@1224|Proteobacteria,1SZPN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Hydrogenase maturation protease	-	-	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
k59_797994_1	927677.ALVU02000006_gene450	1.41e-18	89.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	ydjP	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
k59_852432_1	198467.NP92_04890	5.85e-10	60.5	COG0683@1|root,COG0683@2|Bacteria,1TPQ2@1239|Firmicutes,4I3GI@91061|Bacilli,21WI5@150247|Anoxybacillus	91061|Bacilli	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_852432_2	326427.Cagg_2426	2.65e-31	119.0	COG4177@1|root,COG4177@2|Bacteria,2G6HP@200795|Chloroflexi,376DG@32061|Chloroflexia	32061|Chloroflexia	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_185880_2	926569.ANT_22920	6.5e-46	149.0	COG0759@1|root,COG0759@2|Bacteria,2G76Q@200795|Chloroflexi	200795|Chloroflexi	S	Could be involved in insertion of integral membrane proteins into the membrane	-	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
k59_465062_1	296591.Bpro_4806	1.62e-61	198.0	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,2VNSH@28216|Betaproteobacteria,4AJ48@80864|Comamonadaceae	28216|Betaproteobacteria	L	Phage integrase, N-terminal SAM-like domain	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_4,Phage_integrase
k59_742435_1	861299.J421_3193	8.46e-50	170.0	COG0341@1|root,COG0341@2|Bacteria,1ZSSV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
k59_1299965_1	671143.DAMO_2311	4.98e-05	44.7	COG1428@1|root,COG1428@2|Bacteria,2NPEH@2323|unclassified Bacteria	2|Bacteria	F	Deoxynucleoside kinase	dgk	-	2.7.1.113	ko:K15518	ko00230,map00230	-	R01967	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	HPPK,dNK
k59_1299965_2	985665.HPL003_07835	1.05e-25	103.0	COG0801@1|root,COG0801@2|Bacteria,1V6PR@1239|Firmicutes,4HIMG@91061|Bacilli,26USM@186822|Paenibacillaceae	91061|Bacilli	H	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	-	2.7.6.3	ko:K00950	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HPPK
k59_1411232_2	457421.CBFG_00387	3.11e-12	65.9	COG0613@1|root,COG0613@2|Bacteria,1TPI5@1239|Firmicutes,248H2@186801|Clostridia,269V2@186813|unclassified Clostridiales	186801|Clostridia	S	DNA polymerase alpha chain like domain	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP
k59_1689182_1	1031288.AXAA01000033_gene1339	1.3e-65	213.0	COG2309@1|root,COG2309@2|Bacteria,1TP65@1239|Firmicutes,24AR8@186801|Clostridia,36E9B@31979|Clostridiaceae	186801|Clostridia	E	aminopeptidase	-	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
k59_187712_1	1191523.MROS_0276	2.98e-43	152.0	COG0356@1|root,COG0356@2|Bacteria	2|Bacteria	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
k59_799820_1	983545.Glaag_0181	4.97e-32	124.0	COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,1RMWS@1236|Gammaproteobacteria,4646Q@72275|Alteromonadaceae	1236|Gammaproteobacteria	F	COG0138 AICAR transformylase IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)	purH	GO:0003674,GO:0003824,GO:0004643,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016742,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iEcHS_1320.EcHS_A4240,iPC815.YPO3728	AICARFT_IMPCHas,MGS
k59_21436_1	1484460.JSWG01000001_gene2382	6.37e-07	56.2	COG1680@1|root,COG1680@2|Bacteria,4NI1Z@976|Bacteroidetes,1HYQF@117743|Flavobacteriia	976|Bacteroidetes	V	COG1680 Beta-lactamase class C and other penicillin binding proteins	pbpE	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3,Beta-lactamase,DUF3471
k59_799830_1	861299.J421_0488	5e-61	202.0	COG2223@1|root,COG2223@2|Bacteria,1ZT8I@142182|Gemmatimonadetes	142182|Gemmatimonadetes	P	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_854210_1	1095749.HMPREF1052_1267	1.48e-09	58.2	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,1Y7TM@135625|Pasteurellales	135625|Pasteurellales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_854210_2	1247024.JRLH01000016_gene1702	3.68e-31	114.0	COG0222@1|root,COG0222@2|Bacteria,1RGU4@1224|Proteobacteria,1S5V7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0042802,GO:0042803,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0046983,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
k59_521778_1	1051985.l11_03490	1.36e-34	135.0	COG2010@1|root,COG2132@1|root,COG2010@2|Bacteria,COG2132@2|Bacteria,1MV74@1224|Proteobacteria,2VK95@28216|Betaproteobacteria,2KQR4@206351|Neisseriales	206351|Neisseriales	C	Multicopper oxidase	aniA	-	1.7.2.1	ko:K00368	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Cu-oxidase_3,Cytochrom_C,Cytochrome_CBB3
k59_854218_1	936136.ARRT01000002_gene827	2.66e-16	78.2	COG0413@1|root,COG0413@2|Bacteria,1MU3B@1224|Proteobacteria,2TQT1@28211|Alphaproteobacteria,4BAC9@82115|Rhizobiaceae	28211|Alphaproteobacteria	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
k59_854218_2	309803.CTN_1492	2.53e-32	121.0	COG0414@1|root,COG0414@2|Bacteria,2GC24@200918|Thermotogae	200918|Thermotogae	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
k59_1744336_1	502025.Hoch_2840	5.79e-10	63.5	COG0500@1|root,COG2226@2|Bacteria,1PEJ8@1224|Proteobacteria,43148@68525|delta/epsilon subdivisions,2WX1D@28221|Deltaproteobacteria,2YV36@29|Myxococcales	28221|Deltaproteobacteria	Q	Nodulation protein S (NodS)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_631989_1	42256.RradSPS_0464	1.18e-26	110.0	COG2812@1|root,COG2812@2|Bacteria,2GJKA@201174|Actinobacteria,4CP73@84995|Rubrobacteria	84995|Rubrobacteria	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
k59_1188766_1	1040989.AWZU01000035_gene1778	1.27e-70	229.0	COG2079@1|root,COG2079@2|Bacteria,1R5CE@1224|Proteobacteria,2TUP7@28211|Alphaproteobacteria,3JW76@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	MmgE/PrpD family	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
k59_1522207_1	1210908.HSB1_47800	1.97e-74	245.0	COG2217@1|root,arCOG01576@2157|Archaea,2XT3T@28890|Euryarchaeota,23S6X@183963|Halobacteria	183963|Halobacteria	P	copper-translocating P-type ATPase	-	-	3.6.3.4	ko:K01533	-	-	R00086	RC00002	ko00000,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase
k59_131978_2	546414.Deide_22591	1.4e-05	48.5	COG0645@1|root,COG0645@2|Bacteria	2|Bacteria	S	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_33
k59_1632635_1	326427.Cagg_0870	7.42e-28	115.0	COG0415@1|root,COG0415@2|Bacteria,2G5WD@200795|Chloroflexi,375BT@32061|Chloroflexia	32061|Chloroflexia	L	PFAM DNA photolyase, FAD-binding	-	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
k59_1744344_1	1499967.BAYZ01000089_gene5013	1.87e-06	51.6	COG1519@1|root,COG1519@2|Bacteria,2NP5A@2323|unclassified Bacteria	2|Bacteria	M	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase)	waaA	GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234	2.1.1.33,2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527,ko:K03439	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005,ko03016	-	GT30	-	Glycos_transf_N
k59_21477_1	981369.JQMJ01000004_gene6083	8.31e-49	169.0	COG0114@1|root,COG0114@2|Bacteria,2GKWY@201174|Actinobacteria,2NG22@228398|Streptacidiphilus	201174|Actinobacteria	C	Fumarase C C-terminus	fumC	GO:0003674,GO:0003824,GO:0004333,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006106,GO:0006108,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019752,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0071944,GO:0072350	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
k59_410567_1	929712.KI912613_gene3317	7.45e-18	88.2	COG1985@1|root,COG1985@2|Bacteria,2GN2P@201174|Actinobacteria,4CQFX@84995|Rubrobacteria	84995|Rubrobacteria	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
k59_1632650_1	926550.CLDAP_26090	1.1e-31	115.0	COG3335@1|root,COG3335@2|Bacteria,2G9N4@200795|Chloroflexi	200795|Chloroflexi	L	IS630 family ISRj1-like transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
k59_1632650_2	926550.CLDAP_26100	6.83e-57	181.0	COG3415@1|root,COG3415@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_28,HTH_32,HTH_33
k59_187781_1	472759.Nhal_2490	4.08e-90	283.0	COG0366@1|root,COG0366@2|Bacteria,1MWBZ@1224|Proteobacteria,1RYKS@1236|Gammaproteobacteria,1WX35@135613|Chromatiales	135613|Chromatiales	G	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB	glgE	-	2.4.99.16	ko:K16147	ko00500,ko01100,map00500,map01100	-	R09994	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3416
k59_1689250_2	1123257.AUFV01000016_gene3459	2.08e-17	77.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,1RR2W@1236|Gammaproteobacteria,1X8XV@135614|Xanthomonadales	135614|Xanthomonadales	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_689068_1	1379270.AUXF01000006_gene312	2.12e-64	207.0	COG2199@1|root,COG2199@2|Bacteria,1ZT1F@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Diguanylate cyclase, GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
k59_187797_1	1297570.MESS4_370053	8.11e-28	114.0	COG0524@1|root,COG2771@1|root,COG0524@2|Bacteria,COG2771@2|Bacteria,1MXSY@1224|Proteobacteria,2TR08@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	COG0524 Sugar kinases, ribokinase family	psuK	-	2.7.1.83	ko:K16328	ko00240,map00240	-	R03315	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	HTH_24,PfkB
k59_799903_1	1502851.FG93_01511	5.18e-48	171.0	COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,2TSHQ@28211|Alphaproteobacteria,3JSUN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Penicillin-binding Protein	ftsI	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PBP_dimer,Transpeptidase
k59_354309_1	287986.DV20_18745	4.57e-39	144.0	COG0477@1|root,COG0477@2|Bacteria,2IIAH@201174|Actinobacteria,4EF98@85010|Pseudonocardiales	201174|Actinobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
k59_1411325_1	1170562.Cal6303_2402	6.32e-06	55.1	COG3501@1|root,COG3501@2|Bacteria,1G3M3@1117|Cyanobacteria,1HU9B@1161|Nostocales	1117|Cyanobacteria	S	Phage-related baseplate assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	Phage_GPD
k59_1246266_1	313606.M23134_05349	4.78e-61	211.0	COG4447@1|root,COG4447@2|Bacteria,4NESU@976|Bacteroidetes,47M5A@768503|Cytophagia	976|Bacteroidetes	S	Sortilin, neurotensin receptor 3,	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
k59_1744402_1	365046.Rta_06300	7.15e-08	59.7	COG0589@1|root,COG4977@1|root,COG0589@2|Bacteria,COG4977@2|Bacteria,1PE08@1224|Proteobacteria,2VNHV@28216|Betaproteobacteria,4AG0N@80864|Comamonadaceae	28216|Betaproteobacteria	K	Universal stress protein family	uspA	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_35691_1	1304883.KI912532_gene504	6.79e-46	157.0	COG0115@1|root,COG0115@2|Bacteria,1MVAT@1224|Proteobacteria,2VIVK@28216|Betaproteobacteria,2KVN6@206389|Rhodocyclales	206389|Rhodocyclales	EH	Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase	-	-	2.6.1.21	ko:K00824	ko00310,ko00330,ko00360,ko00472,ko00473,ko01100,map00310,map00330,map00360,map00472,map00473,map01100	-	R01148,R01582,R02459,R02851,R02924,R05053	RC00006,RC00008,RC00025	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_4
k59_35691_2	261292.Nit79A3_2239	4.45e-31	111.0	COG2921@1|root,COG2921@2|Bacteria,1RGV5@1224|Proteobacteria,2VTY5@28216|Betaproteobacteria,373HP@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Belongs to the UPF0250 family	ybeD	-	-	ko:K09158	-	-	-	-	ko00000	-	-	-	DUF493
k59_758800_1	639282.DEFDS_1067	5.4e-84	266.0	COG1012@1|root,COG1012@2|Bacteria,2GEJJ@200930|Deferribacteres	200930|Deferribacteres	C	Aldehyde dehydrogenase family	-	-	1.2.1.88	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	-	R00245,R00707,R00708,R04444,R04445,R05051	RC00080,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000	-	-	-	Aldedh
k59_928514_1	411467.BACCAP_02301	1.25e-69	236.0	COG0495@1|root,COG0495@2|Bacteria,1TP0Y@1239|Firmicutes,2484Y@186801|Clostridia,2687P@186813|unclassified Clostridiales	186801|Clostridia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
k59_536666_1	1380355.JNIJ01000008_gene1875	7.55e-31	119.0	COG0559@1|root,COG0559@2|Bacteria,1MVND@1224|Proteobacteria,2TSCF@28211|Alphaproteobacteria,3JQTN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_483325_1	946077.W5A_09209	1.1e-74	233.0	COG1028@1|root,COG1028@2|Bacteria,4NH6Y@976|Bacteroidetes,1HXA4@117743|Flavobacteriia	976|Bacteroidetes	IQ	short-chain dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_1536807_1	745776.DGo_CA2472	9.81e-103	310.0	COG0719@1|root,COG0719@2|Bacteria,1WIDC@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	O	ABC-type transport system involved in Fe-S cluster assembly, permease component	-	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
k59_983206_1	1089551.KE386572_gene1807	1.95e-37	142.0	COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,2TQWI@28211|Alphaproteobacteria,4BPFD@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
k59_1149213_1	1150864.MILUP08_44204	7.5e-21	97.1	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,4D96C@85008|Micromonosporales	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,BTAD,Trans_reg_C
k59_704448_1	991905.SL003B_0699	1.12e-50	164.0	COG3335@1|root,COG3335@2|Bacteria,1P76X@1224|Proteobacteria,2U16U@28211|Alphaproteobacteria,4BRN6@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
k59_704448_2	331869.BAL199_07738	3.82e-18	78.2	COG3415@1|root,COG3415@2|Bacteria,1N7CS@1224|Proteobacteria,2UFAY@28211|Alphaproteobacteria,4BR0R@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_32,HTH_33,HTH_Tnp_IS630
k59_869551_1	643473.KB235930_gene4445	4.52e-85	258.0	COG1125@1|root,COG1125@2|Bacteria,1G21Q@1117|Cyanobacteria,1HIQ3@1161|Nostocales	1117|Cyanobacteria	E	ABC-type proline glycine betaine transport	-	-	-	ko:K05847	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	ABC_tran,CBS
k59_1371274_1	1047013.AQSP01000105_gene1455	2.73e-102	310.0	COG1960@1|root,COG1960@2|Bacteria,2NNRN@2323|unclassified Bacteria	2|Bacteria	I	Dehydrogenase	-	-	1.3.8.1	ko:K00248	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_869560_1	936455.KI421499_gene314	7.63e-08	59.3	COG2079@1|root,COG2079@2|Bacteria,1R5CE@1224|Proteobacteria,2TUP7@28211|Alphaproteobacteria,3JW76@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	MmgE/PrpD family	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
k59_1646632_2	227882.SAV_1557	4.88e-13	65.1	COG0432@1|root,COG0432@2|Bacteria,2IHWS@201174|Actinobacteria	201174|Actinobacteria	S	Pfam Uncharacterised protein family UPF0047	-	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	UPF0047
k59_1149236_1	448385.sce0788	2.01e-26	115.0	COG0515@1|root,COG2114@1|root,COG3899@1|root,COG0515@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,42NXT@68525|delta/epsilon subdivisions,2WIZ3@28221|Deltaproteobacteria,2YU18@29|Myxococcales	28221|Deltaproteobacteria	KLT	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Guanylate_cyc,Pkinase
k59_483367_1	913848.AELK01000235_gene1146	1.37e-41	145.0	COG0092@1|root,COG0092@2|Bacteria,1TPCP@1239|Firmicutes,4HAUR@91061|Bacilli,3F3Q8@33958|Lactobacillaceae	91061|Bacilli	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
k59_483367_2	997346.HMPREF9374_2851	5.13e-27	102.0	COG0091@1|root,COG0091@2|Bacteria,1V6PU@1239|Firmicutes,4HIK2@91061|Bacilli,27C13@186824|Thermoactinomycetaceae	91061|Bacilli	J	Ribosomal protein L22p/L17e	rplV	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
k59_1758186_1	710696.Intca_2217	2.81e-51	181.0	COG4932@1|root,COG4932@2|Bacteria,2IFAA@201174|Actinobacteria	201174|Actinobacteria	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_814609_1	331869.BAL199_03344	5.54e-65	219.0	COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,2TSAP@28211|Alphaproteobacteria,4BPKG@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	ko:K08351	ko00780,ko01100,map00780,map01100	-	R10127	RC03056	ko00000,ko00001,ko01000,ko02000	5.A.3.4	-	-	Molybdopterin,Molydop_binding
k59_928580_1	269799.Gmet_2594	8.57e-56	186.0	COG3240@1|root,COG3240@2|Bacteria,1MWDI@1224|Proteobacteria,42WSP@68525|delta/epsilon subdivisions,2WS6D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	PFAM lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL
k59_1593626_1	983920.Y88_0560	1.28e-21	99.8	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,2TSCN@28211|Alphaproteobacteria,2K1R8@204457|Sphingomonadales	204457|Sphingomonadales	L	DNA polymerase	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP
k59_646189_1	477974.Daud_2088	1.63e-28	117.0	COG0728@1|root,COG0728@2|Bacteria,1TPFI@1239|Firmicutes,247N3@186801|Clostridia,2605U@186807|Peptococcaceae	186801|Clostridia	U	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
k59_704488_2	639282.DEFDS_1440	5.31e-13	74.3	COG0534@1|root,COG0534@2|Bacteria,2GES3@200930|Deferribacteres	200930|Deferribacteres	V	Mate efflux family protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1536851_1	568706.BN118_2378	4.07e-79	248.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,2VJJ1@28216|Betaproteobacteria,3T384@506|Alcaligenaceae	28216|Betaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	nuoF	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
k59_1706159_1	436308.Nmar_1678	5.49e-05	50.4	COG3794@1|root,arCOG02926@2157|Archaea	2157|Archaea	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind
k59_1482632_2	314345.SPV1_12687	6.21e-22	91.7	COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria	1224|Proteobacteria	KT	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_1536861_1	90814.KL370891_gene1173	1.26e-52	176.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,1RNJ1@1236|Gammaproteobacteria,45ZR0@72273|Thiotrichales	72273|Thiotrichales	EP	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033,ko:K15581	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1
k59_1371320_1	1227360.C176_09152	5.6e-15	74.3	COG1131@1|root,COG1131@2|Bacteria,1TPJE@1239|Firmicutes,4HB5U@91061|Bacilli,26IFF@186818|Planococcaceae	91061|Bacilli	V	COG1131 ABC-type multidrug transport system, ATPase component	drrA_1	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
k59_1428082_1	1430440.MGMSRv2_1082	1.6e-110	340.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2TQNY@28211|Alphaproteobacteria,2JPK1@204441|Rhodospirillales	204441|Rhodospirillales	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
k59_317526_2	747682.MALL_0313	1.5e-09	58.2	COG1692@1|root,COG1692@2|Bacteria,3WT0D@544448|Tenericutes	544448|Tenericutes	S	YmdB-like protein	ymdB	-	-	ko:K09769	-	-	-	-	ko00000	-	-	-	YmdB
k59_706579_2	323848.Nmul_A0534	2.76e-29	117.0	COG1404@1|root,COG1404@2|Bacteria,1R5Y1@1224|Proteobacteria,2VS1E@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
k59_1648620_1	395493.BegalDRAFT_1114	2.14e-47	166.0	COG1168@1|root,COG1168@2|Bacteria,1MY33@1224|Proteobacteria,1RP58@1236|Gammaproteobacteria,460EN@72273|Thiotrichales	72273|Thiotrichales	E	PFAM Aminotransferase class I and II	-	-	4.4.1.8	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	-	R00782,R01286,R02408,R04941	RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_760761_1	1089545.KB913037_gene6768	3.64e-16	80.9	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria,4DXBC@85010|Pseudonocardiales	201174|Actinobacteria	KLT	serine threonine protein kinase	pknL	GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018107,GO:0018193,GO:0018210,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0042304,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
k59_203635_1	485913.Krac_4386	2.92e-33	130.0	COG3039@1|root,COG3039@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_485208_1	518766.Rmar_0692	4.74e-91	279.0	COG4952@1|root,COG4952@2|Bacteria,4NFWW@976|Bacteroidetes	976|Bacteroidetes	M	sugar isomerase	-	-	5.3.1.14	ko:K01820	ko00040,ko00051,ko01120,map00040,map00051,map01120	-	R01906,R02437,R06589	RC00376,RC00434,RC00516	ko00000,ko00001,ko01000	-	-	-	-
k59_485208_2	411477.PARMER_01914	7.09e-05	46.2	COG1070@1|root,COG1070@2|Bacteria,4NIJC@976|Bacteroidetes,2FP4C@200643|Bacteroidia,22X3Q@171551|Porphyromonadaceae	976|Bacteroidetes	G	FGGY family of carbohydrate kinases, N-terminal domain	rhaB	GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0009056,GO:0016052,GO:0019299,GO:0019301,GO:0019318,GO:0019320,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0071704,GO:1901575	2.7.1.5,2.7.1.51	ko:K00848,ko:K00879	ko00040,ko00051,ko01120,map00040,map00051,map01120	-	R01902,R03014,R03241	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	FGGY_C,FGGY_N
k59_1095113_1	1078020.KEK_09907	8.82e-16	73.2	COG2261@1|root,COG2261@2|Bacteria,2IQGD@201174|Actinobacteria,23AQ3@1762|Mycobacteriaceae	201174|Actinobacteria	S	transglycosylase associated protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_538605_1	1121468.AUBR01000012_gene2591	3.83e-56	186.0	COG0826@1|root,COG0826@2|Bacteria	2|Bacteria	O	peptidase U32	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_U32
k59_593645_2	1123393.KB891316_gene1355	7.53e-40	146.0	COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,2VHY5@28216|Betaproteobacteria,1KSBC@119069|Hydrogenophilales	119069|Hydrogenophilales	J	Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control	pcnB	-	2.7.7.19	ko:K00970	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PolyA_pol,PolyA_pol_RNAbd,PolyA_pol_arg_C
k59_148567_1	1051632.TPY_0520	2.3e-31	124.0	COG3328@1|root,COG3328@2|Bacteria,1V116@1239|Firmicutes,24D8K@186801|Clostridia	186801|Clostridia	L	Transposase, Mutator family	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_1373304_1	1424334.W822_12200	2.47e-83	263.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2W94J@28216|Betaproteobacteria,3T62S@506|Alcaligenaceae	28216|Betaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K12507	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_485225_1	926566.Terro_0215	3.85e-72	242.0	COG1506@1|root,COG1506@2|Bacteria,3Y3EW@57723|Acidobacteria,2JNZU@204432|Acidobacteriia	204432|Acidobacteriia	E	Dipeptidyl peptidase IV (DPP IV) N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	DPPIV_N,Peptidase_S9
k59_1151118_1	1254432.SCE1572_47310	1.63e-74	234.0	COG1475@1|root,COG1475@2|Bacteria,1Q2AH@1224|Proteobacteria,437X8@68525|delta/epsilon subdivisions,2X9QN@28221|Deltaproteobacteria,2YUMN@29|Myxococcales	28221|Deltaproteobacteria	K	ParB-like nuclease domain	-	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
k59_1648657_2	379066.GAU_1887	7.96e-56	181.0	COG0669@1|root,COG0669@2|Bacteria,1ZTTQ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
k59_1205674_1	931626.Awo_c32790	1.07e-42	155.0	COG0403@1|root,COG0403@2|Bacteria,1TQGG@1239|Firmicutes,2492A@186801|Clostridia,25V3E@186806|Eubacteriaceae	186801|Clostridia	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
k59_706631_1	285514.JNWO01000001_gene4732	1.13e-78	243.0	COG1071@1|root,COG1071@2|Bacteria,2GK3W@201174|Actinobacteria	201174|Actinobacteria	C	Dehydrogenase E1 component	acoA	-	1.2.4.1	ko:K00161,ko:K21416	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
k59_593667_1	1219035.NT2_05_02760	0.000111	47.8	COG1902@1|root,COG1902@2|Bacteria,1MVIX@1224|Proteobacteria,2TT2F@28211|Alphaproteobacteria,2K1VZ@204457|Sphingomonadales	204457|Sphingomonadales	C	PFAM NADH flavin oxidoreductase NADH oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
k59_1595633_1	926567.TheveDRAFT_0628	4.6e-54	181.0	COG1978@1|root,COG1978@2|Bacteria,3TA3Z@508458|Synergistetes	508458|Synergistetes	S	Selenoprotein B, glycine betaine sarcosine D-proline reductase family	-	-	1.21.4.2	ko:K10672	-	-	-	-	ko00000,ko01000	-	-	-	GRDB
k59_985169_2	710685.MycrhN_1675	4.05e-06	53.5	COG0778@1|root,COG0778@2|Bacteria,2GM9M@201174|Actinobacteria,233N5@1762|Mycobacteriaceae	201174|Actinobacteria	C	nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
k59_760803_1	1324957.K933_08532	0.000109	50.8	COG3391@1|root,arCOG02562@2157|Archaea	2157|Archaea	Q	40-residue YVTN family beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	FG-GAP,FG-GAP_2
k59_1151132_2	1440774.Y900_024510	2.31e-07	55.1	COG0438@1|root,COG0438@2|Bacteria,2ID2E@201174|Actinobacteria,2377Z@1762|Mycobacteriaceae	201174|Actinobacteria	M	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
k59_371709_1	316057.RPD_0676	3.06e-15	80.5	COG1009@1|root,COG2111@1|root,COG1009@2|Bacteria,COG2111@2|Bacteria,1MW2M@1224|Proteobacteria,2TRIR@28211|Alphaproteobacteria,3JU45@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	CP	Na H antiporter MnhB subunit-related protein	phaAB	-	-	ko:K05559	-	-	-	-	ko00000,ko02000	2.A.63.1	-	-	DUF4040,MnhB,Proton_antipo_M,Proton_antipo_N
k59_1263734_1	639282.DEFDS_1053	5.67e-25	96.7	COG1925@1|root,COG1925@2|Bacteria,2GG2N@200930|Deferribacteres	200930|Deferribacteres	G	PTS HPr component phosphorylation site	-	-	-	ko:K11189	-	-	-	-	ko00000,ko02000	4.A.2.1	-	-	PTS-HPr
k59_317600_1	935839.JAGJ01000011_gene445	1.57e-22	99.0	COG0030@1|root,COG0030@2|Bacteria,2GKBT@201174|Actinobacteria,4F3NN@85017|Promicromonosporaceae	201174|Actinobacteria	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
k59_93755_1	1137269.AZWL01000015_gene583	6.36e-52	176.0	COG0451@1|root,COG0451@2|Bacteria,2I2SW@201174|Actinobacteria	201174|Actinobacteria	GM	PFAM NAD-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
k59_259687_1	314232.SKA53_05740	1.44e-37	140.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,2TR32@28211|Alphaproteobacteria,2P8MM@245186|Loktanella	28211|Alphaproteobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_148608_1	929712.KI912613_gene2315	3.34e-29	108.0	COG1975@1|root,COG1975@2|Bacteria,2IJ4H@201174|Actinobacteria,4CTVX@84995|Rubrobacteria	84995|Rubrobacteria	O	XdhC and CoxI family	-	-	-	-	-	-	-	-	-	-	-	-	XdhC_CoxI
k59_148608_2	485913.Krac_6952	5.75e-10	59.7	COG1975@1|root,COG3350@1|root,COG1975@2|Bacteria,COG3350@2|Bacteria,2G88Z@200795|Chloroflexi	200795|Chloroflexi	O	YHS domain	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI,YHS
k59_93771_1	1380390.JIAT01000009_gene593	5.07e-08	56.6	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,4CSH6@84995|Rubrobacteria	84995|Rubrobacteria	C	Aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
k59_93771_2	1449353.JQMQ01000005_gene5674	1.67e-05	48.1	COG0824@1|root,COG0824@2|Bacteria,2II60@201174|Actinobacteria	201174|Actinobacteria	S	Thioesterase	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
k59_1041523_1	330214.NIDE2074	1.07e-125	365.0	COG1697@1|root,COG1697@2|Bacteria	2|Bacteria	L	DNA topoisomerase VI subunit A	top6A	-	5.99.1.3	ko:K03166	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	DUF2220,DUF3322,TP6A_N
k59_485285_1	1380390.JIAT01000010_gene4306	2.17e-82	258.0	COG0451@1|root,COG0451@2|Bacteria,2GN90@201174|Actinobacteria,4CRU1@84995|Rubrobacteria	84995|Rubrobacteria	M	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
k59_1041531_2	383372.Rcas_3430	0.000237	46.2	COG2010@1|root,COG3391@1|root,COG2010@2|Bacteria,COG3391@2|Bacteria,2G80B@200795|Chloroflexi,377VY@32061|Chloroflexia	32061|Chloroflexia	C	Cytochrome c	-	-	1.7.2.1,1.7.99.1	ko:K15864	ko00910,ko01120,map00910,map01120	M00529	R00143,R00783,R00785	RC00086,RC02797	ko00000,ko00001,ko00002,ko01000	-	-	-	-
k59_1484660_1	526222.Desal_0993	5.07e-62	198.0	COG1121@1|root,COG1121@2|Bacteria,1MUDW@1224|Proteobacteria,42UDG@68525|delta/epsilon subdivisions,2WQAB@28221|Deltaproteobacteria,2MAG3@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K09817	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC_tran
k59_1444221_1	1121106.JQKB01000039_gene4505	2.39e-56	189.0	COG1252@1|root,COG1252@2|Bacteria,1MX96@1224|Proteobacteria,2TQT2@28211|Alphaproteobacteria,2JQWK@204441|Rhodospirillales	204441|Rhodospirillales	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_273805_1	909663.KI867150_gene2754	1.63e-32	114.0	COG2442@1|root,COG2442@2|Bacteria,1NH1S@1224|Proteobacteria,42X0V@68525|delta/epsilon subdivisions,2WRHP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Protein of unknown function (DUF433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
k59_273805_2	909663.KI867150_gene2755	2.21e-44	147.0	COG4634@1|root,COG4634@2|Bacteria,1RH7A@1224|Proteobacteria,42Y3E@68525|delta/epsilon subdivisions,2WSPC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Mut7-C
k59_1611006_1	1380394.JADL01000001_gene2614	3.31e-53	181.0	COG1960@1|root,COG1960@2|Bacteria,1MXMQ@1224|Proteobacteria,2U0CV@28211|Alphaproteobacteria,2JW09@204441|Rhodospirillales	204441|Rhodospirillales	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.14.13.235	ko:K22027	-	-	-	-	ko00000,ko01000	-	-	-	Acyl-CoA_dh_2,Acyl-CoA_dh_N
k59_1111321_1	641524.ADICYQ_2886	9.04e-27	109.0	COG4798@1|root,COG4798@2|Bacteria,4NII9@976|Bacteroidetes	976|Bacteroidetes	S	Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_12,Methyltransf_25,Methyltransf_31
k59_553117_1	1416752.AYME01000017_gene1989	4.44e-10	65.1	COG0667@1|root,COG0667@2|Bacteria,2H2ID@201174|Actinobacteria,4FR1S@85023|Microbacteriaceae	201174|Actinobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_1777546_1	123214.PERMA_0633	5.71e-30	119.0	COG0682@1|root,COG0682@2|Bacteria,2G41A@200783|Aquificae	200783|Aquificae	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
k59_553139_1	671143.DAMO_0416	2.26e-24	107.0	COG0784@1|root,COG3829@1|root,COG4191@1|root,COG0784@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,2NS4C@2323|unclassified Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CBS,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
k59_387678_1	7719.XP_002127161.1	2.19e-49	173.0	COG2021@1|root,2QR3J@2759|Eukaryota,38CHD@33154|Opisthokonta,3BKU1@33208|Metazoa,3D3SC@33213|Bilateria,48E2P@7711|Chordata	33208|Metazoa	H	alpha/beta hydrolase fold	-	-	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
k59_1611057_1	671143.DAMO_3119	1.96e-34	129.0	COG1893@1|root,COG1893@2|Bacteria,2NPMG@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	panE	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
k59_1777574_1	225849.swp_3730	3.95e-28	113.0	COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,1RN44@1236|Gammaproteobacteria,2QADP@267890|Shewanellaceae	1236|Gammaproteobacteria	H	Belongs to the ribF family	ribF	GO:0003674,GO:0003824,GO:0003919,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008531,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016779,GO:0044237,GO:0070566	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	iETEC_1333.ETEC_0025,iJN746.PP_0602	FAD_syn,Flavokinase
k59_1000708_1	314230.DSM3645_19213	2.52e-35	137.0	2EZGH@1|root,33SMP@2|Bacteria,2J26X@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1000719_1	13690.CP98_00582	7.12e-15	74.7	COG0565@1|root,COG2827@1|root,COG0565@2|Bacteria,COG2827@2|Bacteria,1N47Y@1224|Proteobacteria,2TS8J@28211|Alphaproteobacteria,2JZUG@204457|Sphingomonadales	204457|Sphingomonadales	J	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA	trmJ	-	-	ko:K02533	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	GIY-YIG,SpoU_methylase
k59_389183_2	697284.ERIC2_c06630	3.57e-16	76.6	COG4293@1|root,COG4293@2|Bacteria,1V7WR@1239|Firmicutes,4HJQG@91061|Bacilli,26XJ2@186822|Paenibacillaceae	91061|Bacilli	S	Domain of unknown function (DUF1802)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1802
k59_1612275_1	331869.BAL199_16573	6.57e-73	228.0	COG4598@1|root,COG4598@2|Bacteria,1QTS2@1224|Proteobacteria,2TVZC@28211|Alphaproteobacteria,4BQ09@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	3.6.3.21	ko:K02028,ko:K10025	ko02010,map02010	M00235,M00236	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3,3.A.1.3.11	-	-	ABC_tran
k59_1667876_1	1120956.JHZK01000004_gene1455	9.64e-74	238.0	COG1793@1|root,COG1793@2|Bacteria,1MV3S@1224|Proteobacteria,2TRQ9@28211|Alphaproteobacteria,1JNQU@119043|Rhodobiaceae	28211|Alphaproteobacteria	L	ATP dependent DNA ligase C terminal region	lig	-	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
k59_444807_1	1115512.EH105704_02_04160	4.63e-25	107.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,1RMY7@1236|Gammaproteobacteria,3XNDT@561|Escherichia	1236|Gammaproteobacteria	C	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor	gltD	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_11,Fer4_20,Pyr_redox_2
k59_555995_1	66377.JOBH01000002_gene568	4.22e-11	65.5	COG2909@1|root,COG2909@2|Bacteria,2GJXF@201174|Actinobacteria	201174|Actinobacteria	K	luxR family	-	-	-	ko:K03556,ko:K06886	-	-	-	-	ko00000,ko03000	-	-	-	AAA_16,GerE
k59_889567_1	932678.THERU_06120	1.13e-24	110.0	COG5009@1|root,COG5009@2|Bacteria,2G3MT@200783|Aquificae	200783|Aquificae	M	Penicillin-binding protein 1A	mrcA	GO:0003674,GO:0005488,GO:0005515,GO:0042802	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
k59_1612289_1	338966.Ppro_3460	8.36e-17	80.9	COG2909@1|root,COG3629@1|root,COG2909@2|Bacteria,COG3629@2|Bacteria,1MVZZ@1224|Proteobacteria,43AN8@68525|delta/epsilon subdivisions,2X62F@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	BTAD
k59_333639_2	1089551.KE386572_gene4166	2.74e-31	117.0	COG1058@1|root,COG1058@2|Bacteria,1MVG6@1224|Proteobacteria,2TU5C@28211|Alphaproteobacteria,4BQ7R@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	molybdopterin binding domain	cinA1	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
k59_389244_1	1071379.XP_004179616.1	0.000664	48.5	COG0475@1|root,KOG1650@2759|Eukaryota,38R7E@33154|Opisthokonta,3NV2B@4751|Fungi,3QK0F@4890|Ascomycota,3RRAK@4891|Saccharomycetes,3RXZS@4893|Saccharomycetaceae	4751|Fungi	P	to Saccharomyces cerevisiae KHA1 (YJL094C)	KHA1	GO:0003674,GO:0005215,GO:0005451,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005783,GO:0005794,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0006873,GO:0006875,GO:0008150,GO:0008324,GO:0009987,GO:0012505,GO:0015075,GO:0015077,GO:0015078,GO:0015079,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015386,GO:0015491,GO:0015672,GO:0016020,GO:0016021,GO:0019725,GO:0022804,GO:0022821,GO:0022857,GO:0022890,GO:0030001,GO:0030003,GO:0030004,GO:0030007,GO:0031224,GO:0034220,GO:0042592,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044425,GO:0044444,GO:0044464,GO:0046873,GO:0048878,GO:0050801,GO:0051179,GO:0051234,GO:0055065,GO:0055067,GO:0055075,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071804,GO:0071805,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:0099516,GO:1902600	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
k59_945200_1	1236541.BALL01000023_gene2817	1.16e-19	87.8	COG2885@1|root,COG2885@2|Bacteria,1MYBP@1224|Proteobacteria,1RVRF@1236|Gammaproteobacteria,2Q8YI@267890|Shewanellaceae	1236|Gammaproteobacteria	M	Belongs to the ompA family	yiaD	-	-	ko:K12216	-	-	-	-	ko00000,ko02044	3.A.7.9.1	-	-	Gly-zipper_Omp,Gly-zipper_YMGG,OmpA
k59_1445551_2	1286631.X805_19500	3.96e-18	84.3	COG1556@1|root,COG1556@2|Bacteria,1R4TE@1224|Proteobacteria,2VJCF@28216|Betaproteobacteria,1KP3M@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	LUD domain	-	-	-	ko:K00782	-	-	-	-	ko00000	-	-	-	LUD_dom
k59_1334358_1	926569.ANT_11200	4.92e-60	203.0	COG2843@1|root,COG2843@2|Bacteria,2G78I@200795|Chloroflexi	200795|Chloroflexi	M	Bacterial capsule synthesis protein PGA_cap	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
k59_889610_1	335283.Neut_2188	2e-71	236.0	COG1166@1|root,COG1166@2|Bacteria,1MU80@1224|Proteobacteria,2VNM0@28216|Betaproteobacteria,37405@32003|Nitrosomonadales	28216|Betaproteobacteria	H	PFAM Orn DAP Arg decarboxylase 2	speA	-	4.1.1.19	ko:K01585	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N
k59_278077_2	161156.JQKW01000010_gene337	1.1e-26	108.0	COG0319@1|root,COG0854@1|root,COG0319@2|Bacteria,COG0854@2|Bacteria,2GH7V@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	H	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate	pdxJ	-	2.6.99.2	ko:K03474	ko00750,ko01100,map00750,map01100	M00124	R05838	RC01476	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxJ,UPF0054
k59_444864_1	1120965.AUBV01000004_gene1040	3.28e-32	128.0	COG1228@1|root,COG1228@2|Bacteria,4NGGD@976|Bacteroidetes,47R4K@768503|Cytophagia	976|Bacteroidetes	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,SnoaL_2
k59_55709_1	1229780.BN381_20062	9.01e-27	106.0	COG1738@1|root,COG1738@2|Bacteria,2IFDB@201174|Actinobacteria,3UX0S@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	U	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage	-	-	-	ko:K09125	-	-	-	-	ko00000	-	-	-	Vut_1
k59_389274_1	595537.Varpa_3806	1.93e-24	102.0	COG4177@1|root,COG4177@2|Bacteria,1QF6I@1224|Proteobacteria,2VRRP@28216|Betaproteobacteria,4AHRQ@80864|Comamonadaceae	28216|Betaproteobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
k59_389274_2	1449357.JQLK01000005_gene2417	4.03e-38	137.0	COG0559@1|root,COG0559@2|Bacteria,1WK6Q@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	PFAM Branched-chain amino acid transport system permease component	-	-	-	ko:K01997,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_1334380_1	1379270.AUXF01000002_gene1544	7.64e-69	225.0	COG3653@1|root,COG3653@2|Bacteria	2|Bacteria	Q	N-Acyl-D-aspartate D-glutamate deacylase	-	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
k59_1612352_2	926550.CLDAP_18930	6.01e-54	182.0	COG0017@1|root,COG0017@2|Bacteria,2G6PN@200795|Chloroflexi	200795|Chloroflexi	J	tRNA synthetase, class II (D, K and N)	asnS	-	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
k59_722863_1	861299.J421_2622	4.36e-78	245.0	COG1158@1|root,COG1158@2|Bacteria,1ZSXH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	-	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
k59_139_1	861299.J421_4508	1.79e-95	303.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	3.2.1.14	ko:K01183	ko00520,ko01100,map00520,map01100	-	R01206,R02334	RC00467	ko00000,ko00001,ko01000	-	GH18	-	BNR_assoc_N,Big_2,DUF4465,Glyco_hydro_18,Glyco_hydro_9,LRR_5,PKD
k59_1389991_1	452637.Oter_1828	1.55e-20	98.6	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_55730_1	309801.trd_0232	3.64e-12	72.4	COG4166@1|root,COG4166@2|Bacteria,2G5TA@200795|Chloroflexi,27XQ9@189775|Thermomicrobia	189775|Thermomicrobia	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_1667967_1	926567.TheveDRAFT_1267	2.81e-87	275.0	COG0058@1|root,COG0058@2|Bacteria,3T9UV@508458|Synergistetes	508458|Synergistetes	G	alpha-glucan phosphorylase	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
k59_1278823_1	1191523.MROS_2611	1.59e-150	432.0	COG3345@1|root,COG3345@2|Bacteria	2|Bacteria	G	alpha-galactosidase	rafA	GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0004557,GO:0005975,GO:0005976,GO:0006080,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0015925,GO:0016052,GO:0016787,GO:0016798,GO:0043170,GO:0044238,GO:0051069,GO:0051682,GO:0071704,GO:1901575	3.2.1.22	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Dockerin_1,Glyco_hydro_36C,Glyco_hydro_36N,Melibiase,Melibiase_2,Melibiase_2_C
k59_1000844_1	1254432.SCE1572_26325	1.28e-10	61.6	COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,42M0J@68525|delta/epsilon subdivisions,2WK1D@28221|Deltaproteobacteria,2YUFW@29|Myxococcales	28221|Deltaproteobacteria	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
k59_1000844_2	1128427.KB904821_gene341	0.000115	46.6	COG0431@1|root,COG0431@2|Bacteria,1G0HA@1117|Cyanobacteria,1HAB8@1150|Oscillatoriales	1117|Cyanobacteria	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
k59_1556806_1	795666.MW7_1356	3.24e-63	201.0	COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,2VJVA@28216|Betaproteobacteria,1K3KP@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
k59_1556806_2	1123261.AXDW01000023_gene3571	5.21e-09	56.6	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1RMQ4@1236|Gammaproteobacteria,1X4ZP@135614|Xanthomonadales	135614|Xanthomonadales	IQ	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
k59_1334414_1	314270.RB2083_918	1.72e-42	150.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TSGZ@28211|Alphaproteobacteria,3ZI2P@58840|unclassified Rhodobacteraceae	28211|Alphaproteobacteria	L	L COG3547 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_500505_1	1336803.PHEL49_0890	3.25e-39	139.0	COG0589@1|root,COG0589@2|Bacteria,4NHXF@976|Bacteroidetes,1HY7W@117743|Flavobacteriia,3VVV0@52959|Polaribacter	976|Bacteroidetes	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_1556814_1	1007103.AFHW01000004_gene4417	6.13e-25	106.0	COG1063@1|root,COG1063@2|Bacteria,1TXY2@1239|Firmicutes,4I70X@91061|Bacilli,26VSE@186822|Paenibacillaceae	91061|Bacilli	E	Glucose dehydrogenase C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,Glu_dehyd_C
k59_222544_1	880073.Calab_1379	2.3e-76	239.0	COG1186@1|root,COG1186@2|Bacteria,2NNU3@2323|unclassified Bacteria	2|Bacteria	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016149,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
k59_1723591_1	1089550.ATTH01000001_gene237	1.97e-42	157.0	COG0308@1|root,COG0308@2|Bacteria,4NFNJ@976|Bacteroidetes	976|Bacteroidetes	E	Peptidase family M1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
k59_1501213_1	1123377.AUIV01000011_gene2031	7.05e-73	236.0	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,1X3D1@135614|Xanthomonadales	135614|Xanthomonadales	E	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
k59_1723592_1	945713.IALB_2674	1.89e-35	141.0	COG0454@1|root,COG1022@1|root,COG0456@2|Bacteria,COG1022@2|Bacteria	2|Bacteria	I	Amp-dependent synthetase and ligase	fadD	-	2.5.1.16,6.2.1.3	ko:K00797,ko:K01897	ko00061,ko00071,ko00270,ko00330,ko00410,ko00480,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map00270,map00330,map00410,map00480,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00034,M00086,M00133	R01280,R01920,R02869,R08359	RC00004,RC00014,RC00021,RC00053	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
k59_611714_2	3218.PP1S32_334V6.2	0.00027	47.8	COG0412@1|root,KOG3043@2759|Eukaryota,37IHG@33090|Viridiplantae,3GATA@35493|Streptophyta	35493|Streptophyta	Q	carboxymethylenebutenolidase homolog	-	GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005515,GO:0005516,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0071704,GO:0071944,GO:0140096,GO:1901564	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
k59_166958_1	56110.Oscil6304_2616	2.99e-60	206.0	COG3379@1|root,COG3379@2|Bacteria,1G1KP@1117|Cyanobacteria,1H87X@1150|Oscillatoriales	1117|Cyanobacteria	S	type I phosphodiesterase nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
k59_1612413_1	240292.Ava_C0101	6.1e-56	183.0	28HGI@1|root,2Z7SC@2|Bacteria,1FZZQ@1117|Cyanobacteria,1HQYP@1161|Nostocales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1278862_1	194867.ALBQ01000002_gene906	1.17e-65	213.0	COG2224@1|root,COG2224@2|Bacteria,1MWIF@1224|Proteobacteria,2TU0Q@28211|Alphaproteobacteria,2K0CD@204457|Sphingomonadales	204457|Sphingomonadales	C	Isocitrate lyase	aceA	-	4.1.3.1	ko:K01637	ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200	M00012	R00479	RC00311,RC00313	ko00000,ko00001,ko00002,ko01000	-	-	-	ICL
k59_556117_1	595537.Varpa_1521	3.08e-38	136.0	COG0546@1|root,COG0546@2|Bacteria,1RDA7@1224|Proteobacteria,2VIZ2@28216|Betaproteobacteria,4ABA7@80864|Comamonadaceae	28216|Betaproteobacteria	S	TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3	ppaX	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
k59_556117_2	1123487.KB892866_gene1784	3.17e-11	63.9	COG0564@1|root,COG0564@2|Bacteria,1MVDX@1224|Proteobacteria,2VI51@28216|Betaproteobacteria,2KUN8@206389|Rhodocyclales	206389|Rhodocyclales	J	Responsible for synthesis of pseudouridine from uracil	rluC	-	5.4.99.24	ko:K06179	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
k59_1612414_1	1121937.AUHJ01000013_gene866	4.47e-66	214.0	COG0560@1|root,COG0560@2|Bacteria,1MWA3@1224|Proteobacteria,1RNJE@1236|Gammaproteobacteria,4647E@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	phosphoserine phosphatase	serB	GO:0000287,GO:0001505,GO:0003674,GO:0003824,GO:0004647,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006563,GO:0006564,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0017144,GO:0019752,GO:0042133,GO:0042136,GO:0042578,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046872,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.1.3.3	ko:K01079	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R00582	RC00017	ko00000,ko00001,ko00002,ko01000,ko01009	-	-	iE2348C_1286.E2348C_4686,iEC042_1314.EC042_4885,iECO26_1355.ECO26_5594,iECSF_1327.ECSF_4321,iECUMN_1333.ECUMN_5012,iETEC_1333.ETEC_4743,iPC815.YPO0442,iUMNK88_1353.UMNK88_5307	ACT_6,HAD,Hydrolase
k59_166968_1	1382359.JIAL01000001_gene1322	2.61e-64	214.0	COG1225@1|root,COG1225@2|Bacteria	2|Bacteria	O	peroxiredoxin activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF4369,Redoxin,Thioredoxin_8,UnbV_ASPIC,VCBS
k59_1278868_1	1041146.ATZB01000017_gene1511	5.54e-50	169.0	COG1028@1|root,COG1028@2|Bacteria,1MUCH@1224|Proteobacteria,2TQRM@28211|Alphaproteobacteria,4B7EU@82115|Rhizobiaceae	28211|Alphaproteobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_945313_1	477184.KYC_18040	4.35e-08	59.7	COG2273@1|root,COG2304@1|root,COG2931@1|root,COG2273@2|Bacteria,COG2304@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2VKA9@28216|Betaproteobacteria,3T4YM@506|Alcaligenaceae	28216|Betaproteobacteria	Q	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,He_PIG,HemolysinCabind,VWA_2
k59_222580_2	1001240.GY21_15350	3.35e-10	66.2	COG2267@1|root,COG2267@2|Bacteria,2GM56@201174|Actinobacteria,4FM1J@85023|Microbacteriaceae	201174|Actinobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
k59_1112112_2	649639.Bcell_0815	1.08e-15	75.9	COG1309@1|root,COG1309@2|Bacteria,1TSUJ@1239|Firmicutes,4HJER@91061|Bacilli,1ZRHP@1386|Bacillus	91061|Bacilli	K	Transcriptional regulator C-terminal region	XK27_03525	-	-	-	-	-	-	-	-	-	-	-	TetR_C_8,TetR_N
k59_333767_1	74547.PMT_0930	7.43e-13	68.9	COG0730@1|root,COG0730@2|Bacteria	2|Bacteria	S	response to heat	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
k59_291848_1	631362.Thi970DRAFT_03186	2.32e-56	191.0	COG0399@1|root,COG0399@2|Bacteria,1MUMJ@1224|Proteobacteria,1RSDY@1236|Gammaproteobacteria,1X0B5@135613|Chromatiales	135613|Chromatiales	M	Transposase zinc-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
k59_958660_1	765913.ThidrDRAFT_3107	1.23e-71	226.0	COG0811@1|root,COG0811@2|Bacteria,1MX5J@1224|Proteobacteria,1S2ZN@1236|Gammaproteobacteria,1WXSX@135613|Chromatiales	135613|Chromatiales	U	MotA TolQ ExbB proton channel	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
k59_13809_1	285535.JOEY01000038_gene2761	1.2e-111	329.0	COG1071@1|root,COG1071@2|Bacteria,2GK3W@201174|Actinobacteria	201174|Actinobacteria	C	Dehydrogenase E1 component	acoA	-	1.2.4.1	ko:K00161,ko:K21416	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
k59_1681376_1	283942.IL0354	1.04e-38	144.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RMS9@1236|Gammaproteobacteria,2QFAJ@267893|Idiomarinaceae	1236|Gammaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009314,GO:0009380,GO:0009381,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_1625337_1	991905.SL003B_1383	3.58e-57	194.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2TQPZ@28211|Alphaproteobacteria,4BPCV@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	O	Belongs to the peptidase S1C family	degP	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ,PDZ_2,Trypsin_2
k59_13832_2	1002340.AFCF01000060_gene529	2.1e-05	49.3	COG2211@1|root,COG2211@2|Bacteria,1MWSH@1224|Proteobacteria,2U0DN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	COG0477 Permeases of the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	BT1
k59_1459494_1	251221.35211983	1.78e-48	178.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_461291_1	1454004.AW11_01056	2.49e-67	221.0	COG0843@1|root,COG0843@2|Bacteria,1R57U@1224|Proteobacteria,2VJ1N@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Cytochrome C oxidase subunit I	cbaA	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_683751_1	1206729.BAFZ01000041_gene4605	5.73e-42	155.0	COG2267@1|root,COG5607@1|root,COG2267@2|Bacteria,COG5607@2|Bacteria,2H83P@201174|Actinobacteria,4FUCM@85025|Nocardiaceae	201174|Actinobacteria	I	Serine aminopeptidase, S33	pip	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1,F420H2_quin_red
k59_571377_1	1292373.H640_05913	5.84e-14	73.2	COG0498@1|root,COG0498@2|Bacteria,2GJ5F@201174|Actinobacteria,4DNY8@85009|Propionibacteriales	201174|Actinobacteria	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	thrC	GO:0003674,GO:0003824,GO:0004795,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_571377_2	378806.STAUR_7837	1.39e-07	53.5	COG0451@1|root,COG0451@2|Bacteria,1RBSM@1224|Proteobacteria,42XUG@68525|delta/epsilon subdivisions,2WTSY@28221|Deltaproteobacteria,2YX8Q@29|Myxococcales	28221|Deltaproteobacteria	GM	NAD dependent epimerase/dehydratase family	-	-	1.3.1.45	ko:K05281	ko00943,ko01110,map00943,map01110	-	R06562,R06563,R07747,R07751	RC00805	ko00000,ko00001,ko01000	-	-	-	Epimerase
k59_1627502_2	2002.JOEQ01000010_gene6322	1.02e-50	179.0	COG2197@1|root,COG2206@1|root,COG2197@2|Bacteria,COG2206@2|Bacteria,2GJS8@201174|Actinobacteria	201174|Actinobacteria	T	metal-dependent phosphohydrolase, HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,HD_5
k59_1072046_1	880071.Fleli_2536	6.71e-17	81.3	COG1595@1|root,COG1595@2|Bacteria,4NQCH@976|Bacteroidetes,47PTY@768503|Cytophagia	976|Bacteroidetes	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_1572506_1	926569.ANT_07110	5.02e-22	94.4	COG1172@1|root,COG1172@2|Bacteria	2|Bacteria	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
k59_1572506_2	553973.CLOHYLEM_05660	4.06e-28	112.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,247II@186801|Clostridia,21XVN@1506553|Lachnoclostridium	186801|Clostridia	P	Part of an ABC transporter complex involved in carbohydrate import. Could be involved in ribose, galactose and or methyl galactoside import. Responsible for energy coupling to the transport system	-	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
k59_626902_1	926569.ANT_02520	1.52e-79	247.0	COG0609@1|root,COG0609@2|Bacteria,2G6E8@200795|Chloroflexi	200795|Chloroflexi	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
k59_794524_1	861299.J421_2948	5.79e-16	83.2	COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria,1ZSUS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	MU	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag,PD40
k59_238523_1	1207063.P24_00490	8.96e-92	280.0	COG2358@1|root,COG2358@2|Bacteria,1R3ZR@1224|Proteobacteria,2TSND@28211|Alphaproteobacteria,2JW2I@204441|Rhodospirillales	204441|Rhodospirillales	S	NMT1-like family	-	-	-	-	-	-	-	-	-	-	-	-	NMT1_3
k59_1350046_1	1479237.JMLY01000001_gene862	6.31e-99	296.0	COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,1RR0T@1236|Gammaproteobacteria,464Y9@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	PFAM transposase, IS4 family protein	insH6	GO:0000271,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004803,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006139,GO:0006259,GO:0006310,GO:0006313,GO:0006351,GO:0006355,GO:0006629,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009279,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016051,GO:0016070,GO:0016740,GO:0016757,GO:0016758,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019867,GO:0030312,GO:0030313,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031975,GO:0032196,GO:0032774,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044424,GO:0044444,GO:0044462,GO:0044464,GO:0045226,GO:0045893,GO:0045935,GO:0046379,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140097,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1903509,GO:2000112,GO:2001141	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
k59_626935_1	357808.RoseRS_0214	1.13e-70	230.0	COG1884@1|root,COG1884@2|Bacteria,2G62T@200795|Chloroflexi,374XE@32061|Chloroflexia	32061|Chloroflexia	I	TIGRFAM methylmalonyl-CoA mutase, large subunit	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
k59_739007_1	313596.RB2501_14839	7.73e-25	111.0	COG2091@1|root,COG2091@2|Bacteria,4NFQ6@976|Bacteroidetes,1HZHJ@117743|Flavobacteriia	976|Bacteroidetes	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
k59_1405950_2	1196029.ALIM01000030_gene930	1.15e-09	64.3	COG1804@1|root,COG1804@2|Bacteria,1TP54@1239|Firmicutes,4HABI@91061|Bacilli,1ZB0F@1386|Bacillus	91061|Bacilli	C	acyl-CoA transferases carnitine dehydratase	bbsF_2	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
k59_461370_1	1123373.ATXI01000010_gene1014	6.82e-103	310.0	COG0304@1|root,COG0304@2|Bacteria,2GH5C@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_1294331_1	1121440.AUMA01000010_gene371	8.03e-18	87.8	COG4963@1|root,COG4963@2|Bacteria,1MWNY@1224|Proteobacteria,42QEH@68525|delta/epsilon subdivisions,2WKVC@28221|Deltaproteobacteria,2MAS2@213115|Desulfovibrionales	28221|Deltaproteobacteria	U	AAA domain	-	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	AAA_31,CBP_BcsQ,ParA,Response_reg
k59_71392_1	861299.J421_2423	9.6e-37	138.0	COG0495@1|root,COG0495@2|Bacteria,1ZSXC@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Leucyl-tRNA synthetase, Domain 2	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
k59_182351_1	204669.Acid345_3471	1.37e-27	114.0	COG0577@1|root,COG0577@2|Bacteria,3Y41Z@57723|Acidobacteria,2JI5N@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_182351_2	479434.Sthe_3293	6.82e-32	122.0	COG0154@1|root,COG0154@2|Bacteria,2G7KI@200795|Chloroflexi,27YVS@189775|Thermomicrobia	189775|Thermomicrobia	J	Amidase	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
k59_71397_1	1535422.ND16A_2082	2.3e-43	156.0	COG2801@1|root,COG2801@2|Bacteria,1MXKK@1224|Proteobacteria,1RSMZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	PFAM Integrase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_683845_1	1209989.TepiRe1_0615	5e-81	261.0	COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,1TP0H@1239|Firmicutes,247S0@186801|Clostridia,42F3G@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
k59_1350111_1	926569.ANT_15300	3.14e-107	323.0	COG0466@1|root,COG0466@2|Bacteria	2|Bacteria	O	ATP-dependent peptidase activity	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_1461722_1	251229.Chro_2415	7.8e-68	229.0	COG0045@1|root,COG1042@1|root,COG1670@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1670@2|Bacteria,1G2D3@1117|Cyanobacteria,3VIFN@52604|Pleurocapsales	1117|Cyanobacteria	CJ	TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain	-	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
k59_1405976_2	926569.ANT_31670	3.91e-44	148.0	COG0802@1|root,COG0802@2|Bacteria,2G6YV@200795|Chloroflexi	200795|Chloroflexi	S	Threonylcarbamoyl adenosine biosynthesis protein TsaE	-	-	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
k59_1516958_1	1517681.HW45_09625	5.98e-55	187.0	COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,1RQJW@1236|Gammaproteobacteria,1XT8H@135623|Vibrionales	135623|Vibrionales	P	Probably acts as an electrical shunt for an outwardly- directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response	clcA	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	Voltage_CLC
k59_849263_1	1265502.KB905930_gene1481	8e-24	102.0	COG3228@1|root,COG3228@2|Bacteria,1RAHF@1224|Proteobacteria,2VJTJ@28216|Betaproteobacteria,4ACNB@80864|Comamonadaceae	28216|Betaproteobacteria	S	Belongs to the MtfA family	mtfA	-	-	ko:K09933	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_M90
k59_1461733_2	991905.SL003B_2382	1.67e-38	144.0	COG0628@1|root,COG0628@2|Bacteria,1MW0B@1224|Proteobacteria,2TRD3@28211|Alphaproteobacteria,4BRQN@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	AI-2E family transporter	perM	-	-	ko:K03548	-	-	-	-	ko00000,ko02000	2.A.86.1	-	-	AI-2E_transport
k59_126509_1	234267.Acid_3518	8.25e-33	130.0	COG2866@1|root,COG2866@2|Bacteria	2|Bacteria	E	metallocarboxypeptidase activity	-	-	-	ko:K14054	-	-	-	-	ko00000	-	-	-	AstE_AspA,Peptidase_M14
k59_1017101_1	216594.MMAR_0921	7.65e-15	75.5	COG0577@1|root,COG0577@2|Bacteria,2I5G9@201174|Actinobacteria,23906@1762|Mycobacteriaceae	201174|Actinobacteria	V	ABC-type transport system, involved in lipoprotein release, permease component	-	-	-	-	-	-	-	-	-	-	-	-	FtsX
k59_1017101_2	1206733.BAGC01000041_gene1871	9.95e-60	192.0	COG1136@1|root,COG1136@2|Bacteria,2GJQV@201174|Actinobacteria,4G0D9@85025|Nocardiaceae	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1572612_1	555778.Hneap_0971	2.78e-73	242.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1WX32@135613|Chromatiales	135613|Chromatiales	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.6	ko:K01535	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.3.3	-	-	Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k59_849275_1	471856.Jden_2235	1.33e-66	224.0	COG0855@1|root,COG0855@2|Bacteria,2GJ0B@201174|Actinobacteria	201174|Actinobacteria	P	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
k59_126514_1	926569.ANT_18310	1.64e-79	260.0	COG0466@1|root,COG0466@2|Bacteria,2G5TZ@200795|Chloroflexi	200795|Chloroflexi	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_1183532_1	56107.Cylst_1187	3.31e-66	214.0	COG0500@1|root,COG2226@2|Bacteria,1G0WT@1117|Cyanobacteria,1HMI2@1161|Nostocales	1117|Cyanobacteria	Q	Dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	Dimerisation2,Methyltransf_2
k59_1240510_1	926550.CLDAP_34020	1.38e-40	144.0	COG1957@1|root,COG1957@2|Bacteria,2G6R6@200795|Chloroflexi	200795|Chloroflexi	F	PFAM Inosine uridine-preferring nucleoside hydrolase	-	-	3.2.2.1	ko:K01239,ko:K01250	ko00230,ko00760,ko01100,map00230,map00760,map01100	-	R01245,R01273,R01677,R01770,R02143	RC00033,RC00063,RC00122,RC00318,RC00485	ko00000,ko00001,ko01000	-	-	-	IU_nuc_hydro
k59_294093_1	926569.ANT_04530	5.07e-80	261.0	COG0542@1|root,COG0542@2|Bacteria,2G5RA@200795|Chloroflexi	200795|Chloroflexi	O	ATPase AAA-2 domain protein	clpC	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,HTH_17,UVR
k59_461430_2	1191523.MROS_0285	1.42e-36	138.0	2E09V@1|root,32VXB@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_182402_1	379066.GAU_1717	5.68e-54	182.0	COG0820@1|root,COG0820@2|Bacteria,1ZTAJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Radical_SAM
k59_461442_1	323098.Nwi_2365	1.83e-37	139.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,2TSR0@28211|Alphaproteobacteria,3JUVV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Flavin containing amine oxidoreductase	MA20_01895	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
k59_461442_2	1385935.N836_17635	3.18e-35	124.0	2CD0I@1|root,32RWS@2|Bacteria,1G74B@1117|Cyanobacteria	1117|Cyanobacteria	S	Domain of unknown function (DUF4399)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4399
k59_571521_1	720555.BATR1942_01765	2.07e-16	75.9	COG2318@1|root,COG2318@2|Bacteria,1V2BI@1239|Firmicutes,4HF8B@91061|Bacilli,1ZG53@1386|Bacillus	91061|Bacilli	S	Belongs to the metal hydrolase YfiT family	yfiT	-	-	-	-	-	-	-	-	-	-	-	DinB_2
k59_461444_1	318586.Pden_3266	5.82e-46	162.0	COG3181@1|root,COG3181@2|Bacteria,1N3HN@1224|Proteobacteria,2UDSB@28211|Alphaproteobacteria,2PZAG@265|Paracoccus	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_516518_1	1279017.AQYJ01000027_gene1784	1.02e-14	79.0	COG1404@1|root,COG1404@2|Bacteria,1MVJE@1224|Proteobacteria,1RQ2M@1236|Gammaproteobacteria,4683H@72275|Alteromonadaceae	1236|Gammaproteobacteria	O	Peptidase inhibitor I9	-	-	-	-	-	-	-	-	-	-	-	-	Inhibitor_I9,PA,Peptidase_S8
k59_1739340_1	998088.B565_1676	7.5e-07	55.8	COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,1RME0@1236|Gammaproteobacteria,1Y3TN@135624|Aeromonadales	135624|Aeromonadales	C	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)	sucB	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_1683773_1	926569.ANT_18200	1.81e-87	267.0	COG0489@1|root,COG0489@2|Bacteria,2G60P@200795|Chloroflexi	200795|Chloroflexi	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
k59_405250_1	1296415.JACC01000101_gene2772	1.79e-125	365.0	COG3547@1|root,COG3547@2|Bacteria,4PJK5@976|Bacteroidetes,1IMVI@117743|Flavobacteriia,2YM04@290174|Aquimarina	976|Bacteroidetes	L	Transposase IS116/IS110/IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_20
k59_1572675_1	644801.Psest_1620	2.46e-19	91.3	COG3746@1|root,COG3746@2|Bacteria,1RIVS@1224|Proteobacteria,1T12V@1236|Gammaproteobacteria,1Z2QC@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	P	Outer membrane porin OprO	-	-	-	ko:K07221	-	-	-	-	ko00000,ko02000	1.B.5.1	-	-	Porin_O_P
k59_794667_1	67267.JNXT01000001_gene5904	3.08e-05	48.9	COG0477@1|root,COG0477@2|Bacteria,2GIUM@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator superfamily	pqrB	-	-	ko:K08167	-	M00713,M00714	-	-	ko00000,ko00002,ko01504,ko02000	2.A.1.3	-	-	MFS_1
k59_794667_2	1449353.JQMQ01000005_gene1797	9.65e-10	60.8	COG1309@1|root,COG1309@2|Bacteria,2GJXV@201174|Actinobacteria,2NIJ8@228398|Streptacidiphilus	201174|Actinobacteria	K	Bacterial transcriptional repressor C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_11,TetR_N
k59_1683786_1	300852.55771538	1.07e-18	81.3	COG1846@1|root,COG1846@2|Bacteria,1WKGK@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	K	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_34
k59_1294430_1	96561.Dole_0198	1.27e-54	180.0	COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,42MD6@68525|delta/epsilon subdivisions,2WMNX@28221|Deltaproteobacteria,2MNN7@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Cytochrome b(N-terminal)/b6/petB	pcmC	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_B_C,Cytochrome_B
k59_71486_1	675812.VHA_000799	1.75e-12	68.2	COG2001@1|root,COG2001@2|Bacteria,1RHCG@1224|Proteobacteria,1S63F@1236|Gammaproteobacteria,1XXKK@135623|Vibrionales	135623|Vibrionales	K	MraZ protein, putative antitoxin-like	mraZ	-	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
k59_16273_1	861299.J421_3395	2.56e-44	163.0	COG0768@1|root,COG0768@2|Bacteria,1ZSX5@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Penicillin-binding Protein dimerisation domain	-	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
k59_627056_1	1247963.JPHU01000008_gene2801	1.05e-21	95.5	COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,2TUEW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EGP	Major facilitator Superfamily	tetA	-	-	ko:K08151	-	M00668	-	-	ko00000,ko00002,ko01504,ko02000	2.A.1.2.38,2.A.1.2.39,2.A.1.2.4,2.A.1.2.41,2.A.1.2.68,2.A.1.2.75	-	-	MFS_1,Sugar_tr
k59_627056_2	392499.Swit_2746	6.24e-09	57.0	COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,2TQWI@28211|Alphaproteobacteria,2K14B@204457|Sphingomonadales	204457|Sphingomonadales	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
k59_571553_1	314254.OA2633_04636	1.68e-59	197.0	COG0498@1|root,COG0498@2|Bacteria,1R7X1@1224|Proteobacteria,2TUR3@28211|Alphaproteobacteria,43Z64@69657|Hyphomonadaceae	28211|Alphaproteobacteria	E	Pyridoxal-phosphate dependent enzyme	MA20_41710	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_1683795_1	1121939.L861_13180	7.61e-112	334.0	COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,1RN6U@1236|Gammaproteobacteria,1XIMC@135619|Oceanospirillales	135619|Oceanospirillales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_1183595_1	264732.Moth_2112	1.58e-77	253.0	COG2871@1|root,COG3894@1|root,COG2871@2|Bacteria,COG3894@2|Bacteria,1TP0H@1239|Firmicutes,247S0@186801|Clostridia,42F3G@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
k59_516553_1	1089552.KI911559_gene1631	2.74e-17	78.6	COG0817@1|root,COG0817@2|Bacteria,1MUJI@1224|Proteobacteria,2U70Z@28211|Alphaproteobacteria,2JS5T@204441|Rhodospirillales	204441|Rhodospirillales	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	-	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
k59_516553_2	570967.JMLV01000001_gene2454	6e-32	119.0	COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,2TRSK@28211|Alphaproteobacteria,2JPXP@204441|Rhodospirillales	204441|Rhodospirillales	K	transcriptional regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
k59_1128676_1	768679.TTX_0086	5.6e-30	116.0	COG0444@1|root,arCOG00181@2157|Archaea,2XPR3@28889|Crenarchaeota	28889|Crenarchaeota	E	TIGRFAM oligopeptide dipeptide ABC transporter, ATPase subunit	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_1128676_2	7213.XP_004528144.1	2.41e-16	80.1	COG1132@1|root,COG1446@1|root,KOG0055@2759|Eukaryota,KOG1592@2759|Eukaryota,38JIS@33154|Opisthokonta,3BB1E@33208|Metazoa,3CRC6@33213|Bilateria,41XIG@6656|Arthropoda,3SFKJ@50557|Insecta,452A6@7147|Diptera	33208|Metazoa	E	Hydrolase activity	-	-	3.4.19.5	ko:K13051	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Asparaginase_2
k59_1091107_1	1121918.ARWE01000001_gene2400	7.14e-07	50.8	COG0139@1|root,COG0140@1|root,COG0139@2|Bacteria,COG0140@2|Bacteria,1MW67@1224|Proteobacteria,42SGH@68525|delta/epsilon subdivisions,2X7RI@28221|Deltaproteobacteria,43VYJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Phosphoribosyl-AMP cyclohydrolase	hisI	-	3.5.4.19,3.6.1.31	ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-CH,PRA-PH
k59_1091107_2	671143.DAMO_2237	2.6e-51	170.0	COG0107@1|root,COG0107@2|Bacteria,2NNMK@2323|unclassified Bacteria	2|Bacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	GO:0000105,GO:0000107,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009382,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234	3.5.4.19,3.6.1.31	ko:K01663,ko:K02500,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037,R04558	RC00002,RC00010,RC01055,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	iECO111_1330.ECO111_2749,iEcolC_1368.EcolC_1617,iHN637.CLJU_RS05755,iLJ478.TM1036,iSB619.SA_RS14115,iYL1228.KPN_02481	His_biosynth
k59_199979_1	1288826.MSNKSG1_10293	7.34e-115	342.0	COG2072@1|root,COG2072@2|Bacteria,1MU71@1224|Proteobacteria,1RP8X@1236|Gammaproteobacteria,465CT@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	flavoprotein involved in K transport	ethA	-	-	-	-	-	-	-	-	-	-	-	FMO-like,NAD_binding_8,Pyr_redox_2,Pyr_redox_3
k59_367460_1	1147128.BAST_1517	2.41e-81	266.0	COG0542@1|root,COG0542@2|Bacteria,2GJ73@201174|Actinobacteria,4CZDY@85004|Bifidobacteriales	201174|Actinobacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695,ko:K03696	ko01100,ko04213,map01100,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_1147255_1	452637.Oter_2932	2.14e-14	76.6	COG3118@1|root,COG3118@2|Bacteria	2|Bacteria	O	belongs to the thioredoxin family	ybbN	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K03671,ko:K05838	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	TPR_19,TPR_20,Thioredoxin
k59_1037137_1	1434929.X946_1811	4.9e-76	242.0	COG4962@1|root,COG4962@2|Bacteria,1R7EN@1224|Proteobacteria,2VJWJ@28216|Betaproteobacteria,1K2AA@119060|Burkholderiaceae	28216|Betaproteobacteria	U	type II secretion system protein E	cpaF1	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
k59_367478_1	1028800.RG540_PA14400	4.2e-45	162.0	COG0747@1|root,COG0747@2|Bacteria,1MXHN@1224|Proteobacteria,2U1AT@28211|Alphaproteobacteria,4BBUN@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	ABC-type dipeptide transport system, periplasmic component	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_867044_1	1121451.DESAM_22017	1.9e-10	60.5	COG2252@1|root,COG2252@2|Bacteria,1MUV0@1224|Proteobacteria,42MAE@68525|delta/epsilon subdivisions,2WKFF@28221|Deltaproteobacteria,2M7ZE@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Permease family	pbuG	-	-	ko:K06901	-	-	-	-	ko00000,ko02000	2.A.1.40	-	-	Xan_ur_permease
k59_867044_2	797209.ZOD2009_13606	1.38e-17	80.1	COG4818@1|root,arCOG04344@2157|Archaea,2Y00G@28890|Euryarchaeota,23XT0@183963|Halobacteria	183963|Halobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF4870
k59_1703668_1	1121930.AQXG01000009_gene283	3.84e-116	358.0	COG5549@1|root,COG5549@2|Bacteria,4NEA0@976|Bacteroidetes,1IR6U@117747|Sphingobacteriia	976|Bacteroidetes	O	Domain of unknown function (DUF5118)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4953,DUF5117,DUF5118
k59_34050_1	269799.Gmet_1166	1.32e-32	116.0	COG0762@1|root,COG0762@2|Bacteria,1QDB9@1224|Proteobacteria,42VCU@68525|delta/epsilon subdivisions,2WRHX@28221|Deltaproteobacteria,43VQH@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	YGGT family	-	-	-	ko:K02221	-	-	-	-	ko00000,ko02044	-	-	-	YGGT
k59_34050_2	247490.KSU1_C1163	1.18e-24	100.0	COG0345@1|root,COG0345@2|Bacteria,2IY5U@203682|Planctomycetes	203682|Planctomycetes	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
k59_757013_1	867845.KI911784_gene1275	4.59e-85	259.0	COG0714@1|root,COG0714@2|Bacteria,2G66D@200795|Chloroflexi,374V5@32061|Chloroflexia	32061|Chloroflexia	S	ATPase associated with various cellular activities, AAA_5	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
k59_1037163_1	251221.35212674	2.34e-34	130.0	COG0265@1|root,COG0265@2|Bacteria,1G3M4@1117|Cyanobacteria	1117|Cyanobacteria	O	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
k59_1644809_1	926569.ANT_19020	2.39e-68	217.0	COG0050@1|root,COG0050@2|Bacteria,2G5KI@200795|Chloroflexi	200795|Chloroflexi	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
k59_1644809_2	926569.ANT_10030	7.58e-33	115.0	COG0051@1|root,COG0051@2|Bacteria,2G6RB@200795|Chloroflexi	200795|Chloroflexi	J	Involved in the binding of tRNA to the ribosomes	rpsJ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
k59_367509_1	926550.CLDAP_30340	5.13e-80	253.0	COG1721@1|root,COG1721@2|Bacteria,2G7PU@200795|Chloroflexi	200795|Chloroflexi	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
k59_980890_1	1245469.S58_21780	2.44e-111	336.0	COG1053@1|root,COG1053@2|Bacteria,1NZBR@1224|Proteobacteria,2TSN4@28211|Alphaproteobacteria,3JS97@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	MA20_14860	-	1.8.99.2	ko:K00394	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00596	R00860,R04927,R08553	RC00007,RC01239,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_1037197_1	926550.CLDAP_22560	2.88e-89	280.0	COG0534@1|root,COG0534@2|Bacteria,2G78S@200795|Chloroflexi	200795|Chloroflexi	V	PFAM multi antimicrobial extrusion protein MatE	-	-	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
k59_534787_1	264402.Cagra.0483s0039.1.p	1.53e-20	90.9	COG1011@1|root,KOG3109@2759|Eukaryota,37MSC@33090|Viridiplantae,3GFH9@35493|Streptophyta,3HSUW@3699|Brassicales	35493|Streptophyta	S	Haloacid dehalogenase-like hydrolase	-	-	-	ko:K07025,ko:K18551	ko00760,map00760	-	R02323,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2,Hydrolase_like
k59_144733_1	1082705.JIBP01000021_gene3064	1.31e-14	75.1	COG0796@1|root,COG0796@2|Bacteria,1NAI2@1224|Proteobacteria,1RPU9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008881,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016853,GO:0016854,GO:0016855,GO:0030203,GO:0034645,GO:0036361,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0047661,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	iAPECO1_1312.APECO1_2496,iEC042_1314.EC042_4342,iECOK1_1307.ECOK1_4443,iECS88_1305.ECS88_4426,iPC815.YPO3909,iUMN146_1321.UM146_20110,iUTI89_1310.UTI89_C4562	Asp_Glu_race
k59_144733_2	83406.HDN1F_14510	1.96e-34	129.0	COG2199@1|root,COG3706@2|Bacteria,1QVPW@1224|Proteobacteria,1T2GC@1236|Gammaproteobacteria,1JAKM@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
k59_980900_1	395495.Lcho_1330	4.42e-82	261.0	COG1404@1|root,COG5492@1|root,COG1404@2|Bacteria,COG5492@2|Bacteria,1MU3S@1224|Proteobacteria,2VIXC@28216|Betaproteobacteria,1KJFV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Belongs to the peptidase S8 family	mprA	-	-	ko:K14645	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Big_3_2,Big_3_3,Peptidase_S8
k59_481220_1	1126627.BAWE01000002_gene637	2.57e-16	80.5	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
k59_702572_1	1089550.ATTH01000001_gene2149	1.3e-54	180.0	COG2133@1|root,COG2133@2|Bacteria,4PKJE@976|Bacteroidetes,1FJG8@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	G	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
k59_1424234_1	1195246.AGRI_06835	5.27e-20	93.2	COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,1RMIX@1236|Gammaproteobacteria,46453@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	zinc metalloprotease	rseP	GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006355,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016021,GO:0016787,GO:0019219,GO:0019222,GO:0019538,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0043170,GO:0043856,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0045152,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:0140110,GO:1901564,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
k59_867125_1	1128421.JAGA01000003_gene3138	2.72e-59	191.0	COG1136@1|root,COG1136@2|Bacteria	2|Bacteria	V	lipoprotein transporter activity	-	GO:0008150,GO:0009405,GO:0009605,GO:0009607,GO:0043207,GO:0044403,GO:0044419,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0075136	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_926281_1	472759.Nhal_1097	6.28e-57	197.0	COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,1RQSK@1236|Gammaproteobacteria,1WWAD@135613|Chromatiales	135613|Chromatiales	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
k59_812914_2	502025.Hoch_6290	9.29e-24	99.4	COG0384@1|root,COG0384@2|Bacteria,1MUAS@1224|Proteobacteria,42RA9@68525|delta/epsilon subdivisions,2WQIZ@28221|Deltaproteobacteria,2Z0UK@29|Myxococcales	28221|Deltaproteobacteria	S	Phenazine biosynthesis-like protein	-	-	5.3.3.17	ko:K06998	ko00405,ko01130,ko02024,map00405,map01130,map02024	M00835	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	PhzC-PhzF
k59_1703750_1	946077.W5A_04973	2.08e-81	263.0	COG3250@1|root,COG3250@2|Bacteria,4NEWN@976|Bacteroidetes,1HXYF@117743|Flavobacteriia	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 2 family	-	-	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
k59_313278_1	635013.TherJR_0205	5.73e-117	354.0	COG0465@1|root,COG0465@2|Bacteria,1TPTV@1239|Firmicutes,247WQ@186801|Clostridia,260A4@186807|Peptococcaceae	186801|Clostridia	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_1644877_1	1385935.N836_03675	7.7e-10	65.1	COG3629@1|root,COG3629@2|Bacteria,1G5W7@1117|Cyanobacteria,1HEAR@1150|Oscillatoriales	1117|Cyanobacteria	K	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,TPR_12
k59_200098_1	46429.BV95_01884	4.41e-66	212.0	COG2175@1|root,COG2175@2|Bacteria,1MVI6@1224|Proteobacteria,2TVHF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	PFAM Taurine catabolism dioxygenase TauD, TfdA family	-	-	-	ko:K06912	ko00361,ko01120,ko01220,map00361,map01120,map01220	-	R05419,R05493	RC01371,RC01372	ko00000,ko00001,ko01000	-	-	-	TauD
k59_1424271_1	313596.RB2501_04215	3.77e-81	251.0	COG1960@1|root,COG1960@2|Bacteria,4NEKJ@976|Bacteroidetes,1HYD3@117743|Flavobacteriia	976|Bacteroidetes	I	acyl-CoA dehydrogenase	gcdH	-	1.3.8.6	ko:K00252	ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130	M00032	R02487,R02488,R10074	RC00052,RC00156	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_89855_1	880072.Desac_2171	7.87e-42	161.0	COG0417@1|root,COG0417@2|Bacteria	2|Bacteria	L	DNA replication proofreading	polB	-	2.7.7.7	ko:K02336,ko:K06877	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	CarbopepD_reg_2,DNA_pol_B,DNA_pol_B_exo1,RNase_H_2
k59_1644895_1	926560.KE387027_gene825	2.74e-06	50.1	COG1975@1|root,COG1975@2|Bacteria,1WIZE@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	O	XdhC Rossmann domain	-	-	-	-	-	-	-	-	-	-	-	-	XdhC_C,XdhC_CoxI
k59_1644895_2	1121940.AUDZ01000005_gene1833	8.07e-06	50.8	COG1975@1|root,COG1975@2|Bacteria,1R3RT@1224|Proteobacteria,1RQNB@1236|Gammaproteobacteria,1XJ7D@135619|Oceanospirillales	135619|Oceanospirillales	O	Xanthine dehydrogenase	xdhC	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
k59_1703791_1	877415.JNJQ01000038_gene719	2.48e-12	70.9	COG2815@1|root,COG2815@2|Bacteria,1W09V@1239|Firmicutes	1239|Firmicutes	S	TIR domain	-	-	-	-	-	-	-	-	-	-	-	-	TIR_2
k59_980970_1	1235990.HHS_03900	6.06e-12	70.5	COG1118@1|root,COG1118@2|Bacteria	2|Bacteria	P	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system	cysA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008144,GO:0008150,GO:0008272,GO:0008509,GO:0015075,GO:0015103,GO:0015116,GO:0015318,GO:0015399,GO:0015405,GO:0015419,GO:0015698,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034220,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043225,GO:0043492,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0072348,GO:0097159,GO:0097367,GO:0098656,GO:0098660,GO:0098661,GO:0099133,GO:1901265,GO:1901363,GO:1901682,GO:1902358	3.6.3.25,3.6.3.29	ko:K02017,ko:K02045,ko:K10112	ko00920,ko02010,map00920,map02010	M00185,M00189,M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.1,3.A.1.6.1,3.A.1.6.3,3.A.1.8	-	iE2348C_1286.E2348C_2607,iSSON_1240.SSON_2511	ABC_tran,TOBE,TOBE_3
k59_926332_2	506534.Rhein_1760	5.47e-47	157.0	29KMP@1|root,307IZ@2|Bacteria,1REJ6@1224|Proteobacteria,1S7K0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4287)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4287
k59_812959_2	996637.SGM_0111	1.21e-41	150.0	COG0033@1|root,COG0033@2|Bacteria,2H1PI@201174|Actinobacteria	201174|Actinobacteria	G	Phosphoglucomutase	pgm	-	5.4.2.2	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00549	R00959,R01057,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_1201936_1	566552.BIFCAT_00633	5.78e-20	92.0	COG1541@1|root,COG1541@2|Bacteria,2HZHX@201174|Actinobacteria,4D0HV@85004|Bifidobacteriales	201174|Actinobacteria	H	long-chain-fatty-acid--luciferin-component ligase, acyl-protein synthase	-	-	-	-	-	-	-	-	-	-	-	-	LuxE
k59_367606_1	1209072.ALBT01000032_gene2103	7.31e-19	89.4	COG2091@1|root,COG2091@2|Bacteria,1MY8E@1224|Proteobacteria,1RQAI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
k59_926334_1	926550.CLDAP_27210	5.17e-99	299.0	COG0133@1|root,COG0133@2|Bacteria,2G5Q3@200795|Chloroflexi	200795|Chloroflexi	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_757135_1	1349767.GJA_5411	5.54e-09	62.8	COG4206@1|root,COG4206@2|Bacteria,1R47X@1224|Proteobacteria,2WBDR@28216|Betaproteobacteria,475KM@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k59_256215_1	1032480.MLP_09180	4.65e-119	348.0	COG0667@1|root,COG0667@2|Bacteria,2ICZ6@201174|Actinobacteria,4DU0W@85009|Propionibacteriales	201174|Actinobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_867193_1	330214.NIDE2833	9.57e-107	320.0	COG3039@1|root,COG3039@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_1201942_1	1120950.KB892707_gene4780	2.1e-06	54.7	COG0454@1|root,COG0454@2|Bacteria,2H2PG@201174|Actinobacteria,4DNDQ@85009|Propionibacteriales	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
k59_1037287_1	56110.Oscil6304_3914	1.21e-49	164.0	COG2343@1|root,COG2343@2|Bacteria,1G50P@1117|Cyanobacteria,1HAMP@1150|Oscillatoriales	1117|Cyanobacteria	S	COGs COG2343 conserved	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_9
k59_867201_1	926569.ANT_13980	2.05e-81	249.0	COG1192@1|root,COG1192@2|Bacteria,2G62U@200795|Chloroflexi	200795|Chloroflexi	D	PFAM Cobyrinic acid a,c-diamide synthase	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
k59_367624_1	1408224.SAMCCGM7_c4429	2.46e-20	95.1	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4BCMT@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,TPR_8
k59_256233_1	479434.Sthe_1716	8.63e-67	214.0	COG1260@1|root,COG1260@2|Bacteria,2G5YH@200795|Chloroflexi,27Y0U@189775|Thermomicrobia	189775|Thermomicrobia	I	Myo-inositol-1-phosphate synthase	-	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth
k59_1314435_2	1120941.AUBL01000012_gene524	8.25e-05	44.7	COG1131@1|root,COG1131@2|Bacteria,2GN8P@201174|Actinobacteria,4D4EQ@85005|Actinomycetales	201174|Actinobacteria	V	ABC transporter, ATP-binding protein	-	-	-	ko:K20459	ko02010,map02010	M00813	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.124.3,3.A.1.124.4,3.A.1.124.5	-	-	ABC_tran
k59_423637_1	1379270.AUXF01000003_gene3408	1.45e-68	221.0	COG1220@1|root,COG1220@2|Bacteria,1ZSVP@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	-	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA_2,ClpB_D2-small
k59_34221_2	345341.KUTG_01899	3.2e-42	151.0	COG1172@1|root,COG1172@2|Bacteria,2GM2F@201174|Actinobacteria,4DX6R@85010|Pseudonocardiales	201174|Actinobacteria	G	Branched-chain amino acid transport system / permease component	rhaQ	-	-	ko:K10561	ko02010,map02010	M00220	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.9	-	-	BPD_transp_2
k59_1369203_1	555779.Dthio_PD2148	2.76e-85	259.0	COG2820@1|root,COG2820@2|Bacteria,1PMJ1@1224|Proteobacteria,43792@68525|delta/epsilon subdivisions,2X2CA@28221|Deltaproteobacteria,2MFMY@213115|Desulfovibrionales	28221|Deltaproteobacteria	F	Phosphorylase superfamily	-	-	2.4.2.3	ko:K00757	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01876,R02484,R08229	RC00063	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
k59_144861_2	471852.Tcur_4388	6.99e-15	70.9	COG0838@1|root,COG0838@2|Bacteria,2IFDT@201174|Actinobacteria,4EJ14@85012|Streptosporangiales	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	nuoA2	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
k59_200167_1	999425.HMPREF9186_01559	2.25e-26	108.0	COG0566@1|root,COG0566@2|Bacteria,1TP9G@1239|Firmicutes,4HBBI@91061|Bacilli	91061|Bacilli	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	trmH	GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070039,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
k59_1201991_1	861299.J421_3947	7.46e-29	114.0	COG0356@1|root,COG0356@2|Bacteria,1ZSQ5@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
k59_1756601_1	573063.Metin_0517	4.52e-46	166.0	COG0111@1|root,arCOG01754@2157|Archaea,2XU9V@28890|Euryarchaeota,23Q9F@183939|Methanococci	183939|Methanococci	E	D-isomer specific 2-hydroxyacid dehydrogenase catalytic region	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
k59_534939_1	648885.KB316283_gene3866	1.85e-32	130.0	COG1640@1|root,COG3280@1|root,COG1640@2|Bacteria,COG3280@2|Bacteria,1QTVJ@1224|Proteobacteria,2TW4K@28211|Alphaproteobacteria,1JQW8@119045|Methylobacteriaceae	28211|Alphaproteobacteria	G	SMART alpha amylase catalytic sub domain	malQ	-	2.4.1.25,5.4.99.15	ko:K00705,ko:K06044	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01824,R05196,R09995	RC00049	ko00000,ko00001,ko00002,ko01000	-	GH13,GH77	-	Alpha-amylase,Glyco_hydro_77
k59_1259499_1	754027.HMPREF9554_02227	1.11e-77	242.0	COG0444@1|root,COG0444@2|Bacteria,2J62R@203691|Spirochaetes	203691|Spirochaetes	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
k59_644697_1	1265505.ATUG01000001_gene2915	1.5e-06	55.1	COG1139@1|root,COG1139@2|Bacteria,1MV6J@1224|Proteobacteria,42MN2@68525|delta/epsilon subdivisions,2WIMJ@28221|Deltaproteobacteria,2MHYD@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Domain of unknown function (DUF3390)	-	-	-	ko:K18929	-	-	-	-	ko00000	-	-	-	DUF3390,Fer4_8,LUD_dom
k59_367707_2	555088.DealDRAFT_1137	5.04e-29	116.0	COG0507@1|root,COG0507@2|Bacteria,1TPZH@1239|Firmicutes,247R7@186801|Clostridia,42KG3@68298|Syntrophomonadaceae	186801|Clostridia	L	DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity	recD2	-	3.1.11.5	ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_30,HHH_4,HHH_5,UvrD_C_2
k59_1147511_1	991905.SL003B_3644	7.49e-79	242.0	COG2171@1|root,COG2171@2|Bacteria,1MU0Y@1224|Proteobacteria,2TS3H@28211|Alphaproteobacteria,4BP6K@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the transferase hexapeptide repeat family	dapD	-	2.3.1.117	ko:K00674	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04365	RC00004,RC01136	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2,THDPS_N_2
k59_1706166_1	765420.OSCT_2041	6.83e-74	235.0	COG0438@1|root,COG0438@2|Bacteria,2G84C@200795|Chloroflexi,375HH@32061|Chloroflexia	32061|Chloroflexia	M	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1,Methyltransf_11
k59_146599_1	671143.DAMO_0826	9.91e-92	292.0	COG3005@1|root,COG3005@2|Bacteria	2|Bacteria	C	denitrification pathway	-	-	-	ko:K02569,ko:K15876	ko00910,ko01120,map00910,map01120	M00530	R05712	RC00176	ko00000,ko00001,ko00002	-	-	-	Cytochrom_NNT,Cytochrome_C7
k59_1612150_2	1382306.JNIM01000001_gene2944	3.81e-06	47.8	COG1260@1|root,COG1260@2|Bacteria,2G5YH@200795|Chloroflexi	200795|Chloroflexi	I	Myo-inositol-1-phosphate synthase, GAPDH domain protein	-	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth
k59_54176_2	290397.Adeh_0272	4.82e-59	189.0	COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,42NNS@68525|delta/epsilon subdivisions,2WMS3@28221|Deltaproteobacteria,2YVCJ@29|Myxococcales	28221|Deltaproteobacteria	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
k59_166316_1	1123037.AUDE01000009_gene1279	3.26e-107	325.0	COG1574@1|root,COG1574@2|Bacteria,4NFMV@976|Bacteroidetes,1HYK7@117743|Flavobacteriia	976|Bacteroidetes	S	metal-dependent hydrolase with the TIM-barrel fold	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_274781_1	887062.HGR_02783	8.45e-36	135.0	COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,2VHFR@28216|Betaproteobacteria,4AAGK@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM cytochrome bd ubiquinol oxidase subunit I	cydA	-	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_I
k59_274781_2	887062.HGR_02778	1.44e-51	172.0	COG1294@1|root,COG1294@2|Bacteria,1MURP@1224|Proteobacteria,2VHSQ@28216|Betaproteobacteria,4AD1I@80864|Comamonadaceae	28216|Betaproteobacteria	C	cytochrome d ubiquinol oxidase, subunit II	cydB	-	1.10.3.14	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_II
k59_444628_1	706191.PANA_4185	1.36e-61	205.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria,3VZHH@53335|Pantoea	1236|Gammaproteobacteria	C	Dehydrogenase	yneI	GO:0001505,GO:0003674,GO:0003824,GO:0004777,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006576,GO:0006595,GO:0006598,GO:0006807,GO:0008150,GO:0008152,GO:0009013,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009308,GO:0009310,GO:0009445,GO:0009447,GO:0009448,GO:0009450,GO:0009987,GO:0016054,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0032787,GO:0034641,GO:0042133,GO:0042135,GO:0042402,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:0072329,GO:0097164,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.2.1.16,1.2.1.20,1.2.1.24,1.2.1.79	ko:K00135,ko:K08324	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	iECUMN_1333.ECUMN_1793	Aldedh
k59_999987_1	926692.AZYG01000045_gene686	2.79e-60	197.0	COG5322@1|root,COG5322@2|Bacteria,1TQ2E@1239|Firmicutes,24A1Y@186801|Clostridia,3WBHQ@53433|Halanaerobiales	186801|Clostridia	S	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_444638_1	861299.J421_4117	1.59e-43	147.0	COG2318@1|root,COG2318@2|Bacteria,1ZV1M@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB
k59_54223_1	768671.ThimaDRAFT_3983	8.53e-14	71.2	COG5642@1|root,COG5642@2|Bacteria,1QHRC@1224|Proteobacteria,1SGWX@1236|Gammaproteobacteria,1X276@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF2384)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2384
k59_54238_1	873533.HMPREF0663_12227	7.39e-71	235.0	COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,4NFUJ@976|Bacteroidetes,2FM2T@200643|Bacteroidia	976|Bacteroidetes	C	Psort location Cytoplasmic, score	maeB	-	1.1.1.38,1.1.1.40	ko:K00027,ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,ko02020,map00620,map00710,map01100,map01120,map01200,map02020	M00169,M00172	R00214,R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,PTA_PTB,malic
k59_664432_1	443144.GM21_2959	2.85e-74	247.0	COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,42MDI@68525|delta/epsilon subdivisions,2WIVY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	malic protein domain protein	mdh	-	1.1.1.40	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00169,M00172	R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,PTA_PTB,malic
k59_444669_1	670307.HYPDE_29063	1.95e-17	86.3	COG0658@1|root,COG0658@2|Bacteria,1MUKF@1224|Proteobacteria,2TRD5@28211|Alphaproteobacteria,3N62J@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4131)	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131
k59_166407_1	575540.Isop_1950	8.76e-70	230.0	COG1290@1|root,COG2010@1|root,COG1290@2|Bacteria,COG2010@2|Bacteria,2IX9E@203682|Planctomycetes	203682|Planctomycetes	C	Cytochrome b subunit of the bc complex	-	-	-	ko:K00412	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko03029	-	-	-	Cytochrom_B_C,Cytochrom_B_N_2,Cytochrom_C,Cytochrome_B
k59_1221241_1	1408433.JHXV01000024_gene1471	1.1e-98	295.0	COG0451@1|root,COG0451@2|Bacteria,4NEZX@976|Bacteroidetes,1HWT7@117743|Flavobacteriia,2PAAK@246874|Cryomorphaceae	976|Bacteroidetes	M	PFAM NAD dependent epimerase dehydratase family	-	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
k59_776191_1	580332.Slit_2078	1.55e-83	261.0	COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,2VIIH@28216|Betaproteobacteria,44V5Z@713636|Nitrosomonadales	28216|Betaproteobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_166420_1	1005048.CFU_3095	1.49e-26	110.0	COG0577@1|root,COG1136@1|root,COG0577@2|Bacteria,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,2VHZ2@28216|Betaproteobacteria,472VS@75682|Oxalobacteraceae	28216|Betaproteobacteria	V	Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides	macB	-	-	ko:K05685	ko02010,map02010	M00709	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.122.1,3.A.1.122.12	-	-	ABC_tran,FtsX,MacB_PCD
k59_166420_2	1379270.AUXF01000001_gene2651	3.98e-11	64.7	COG0577@1|root,COG0577@2|Bacteria,1ZURT@142182|Gemmatimonadetes	142182|Gemmatimonadetes	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_664501_1	1121943.KB900010_gene2731	6.84e-36	139.0	COG3391@1|root,COG5126@1|root,COG3391@2|Bacteria,COG5126@2|Bacteria,1RGAJ@1224|Proteobacteria,1S2QK@1236|Gammaproteobacteria,1XPCZ@135619|Oceanospirillales	135619|Oceanospirillales	DTZ	Ca2 -binding protein (EF-Hand superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_444737_1	1459636.NTE_02750	3.61e-95	305.0	COG0085@1|root,arCOG01762@2157|Archaea,41SF5@651137|Thaumarchaeota	651137|Thaumarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	-	-	2.7.7.6	ko:K13798	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_4,RNA_pol_Rpb2_5,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_1221255_1	519989.ECTPHS_12657	4.05e-88	290.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WWAU@135613|Chromatiales	135613|Chromatiales	U	Hydrophobe Amphiphile Efflux-1 (HAE1)	-	-	-	ko:K03296,ko:K18138,ko:K18299	ko01501,ko01503,map01501,map01503	M00641,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2,2.A.6.2.16	-	-	ACR_tran
k59_444758_1	1292020.H483_0118470	4.17e-51	173.0	COG3464@1|root,COG3464@2|Bacteria,2GJK7@201174|Actinobacteria	201174|Actinobacteria	L	Transposase	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K07485	-	-	-	-	ko00000	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3
k59_166460_2	1499967.BAYZ01000076_gene753	1.89e-12	67.8	COG0412@1|root,COG0412@2|Bacteria,2NPZG@2323|unclassified Bacteria	2|Bacteria	Q	Dienelactone hydrolase family	dlhH	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
k59_166472_1	203122.Sde_2082	1.31e-10	65.9	COG3170@1|root,COG3170@2|Bacteria,1MXV7@1224|Proteobacteria,1RMM5@1236|Gammaproteobacteria,4646P@72275|Alteromonadaceae	1236|Gammaproteobacteria	NU	COG3170 Tfp pilus assembly protein FimV	fimV	-	-	ko:K08086	-	-	-	-	ko00000	-	-	-	LysM,TPR_19
k59_166472_2	1122604.JONR01000026_gene2974	1.27e-14	70.5	COG0262@1|root,COG0262@2|Bacteria,1RH0P@1224|Proteobacteria,1S5VH@1236|Gammaproteobacteria,1X6FH@135614|Xanthomonadales	135614|Xanthomonadales	H	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis	-	-	1.5.1.3	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	M00126,M00840	R00936,R00937,R00939,R00940,R02235,R02236,R11765	RC00109,RC00110,RC00158	ko00000,ko00001,ko00002,ko01000	-	-	-	DHFR_1
k59_1221273_1	765914.ThisiDRAFT_0689	5.23e-27	114.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,1RYUH@1236|Gammaproteobacteria,1X2A1@135613|Chromatiales	135613|Chromatiales	T	SMART Adenylyl cyclase class-3 4 guanylyl cyclase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
k59_1722456_1	869210.Marky_2194	1.21e-71	234.0	COG1164@1|root,COG1164@2|Bacteria,1WIBY@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	TIGRFAM oligoendopeptidase, pepF M3 family	-	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
k59_166546_1	105559.Nwat_2283	2.7e-63	206.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RNGU@1236|Gammaproteobacteria,1WXJN@135613|Chromatiales	135613|Chromatiales	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_274883_1	926549.KI421517_gene2293	5.03e-12	70.1	COG0457@1|root,COG0457@2|Bacteria,4NH2F@976|Bacteroidetes,47N0J@768503|Cytophagia	976|Bacteroidetes	S	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
k59_776315_1	391009.Tmel_0564	1.07e-15	83.6	COG0747@1|root,COG0747@2|Bacteria,2GC1T@200918|Thermotogae	200918|Thermotogae	E	PFAM extracellular solute-binding protein, family 5	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_5
k59_776315_2	1125863.JAFN01000001_gene886	2.03e-11	65.1	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,42N1P@68525|delta/epsilon subdivisions,2WM2V@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM aminotransferase class I and II	-	-	-	ko:K10907	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_218301_1	1304275.C41B8_03761	7.59e-06	55.1	COG1879@1|root,COG1879@2|Bacteria,1MUAT@1224|Proteobacteria,1RXX7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Binds AI-2 and delivers it to the LsrC and LsrD permeases	-	-	-	ko:K10559	ko02010,map02010	M00220	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.9	-	-	Peripla_BP_4
k59_1722503_1	97139.C824_04890	2.51e-71	218.0	COG1943@1|root,COG1943@2|Bacteria,1V53Y@1239|Firmicutes,25CMQ@186801|Clostridia,36VU7@31979|Clostridiaceae	186801|Clostridia	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
k59_388861_1	742159.HMPREF0004_3178	1.44e-57	199.0	COG0277@1|root,COG3119@1|root,COG0277@2|Bacteria,COG3119@2|Bacteria,1MU6Y@1224|Proteobacteria,2VI09@28216|Betaproteobacteria,3T1ES@506|Alcaligenaceae	28216|Betaproteobacteria	C	FAD linked oxidases, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_664708_1	1121875.KB907546_gene2238	2.95e-73	230.0	COG1409@1|root,COG1409@2|Bacteria,4NFAP@976|Bacteroidetes,1I2DE@117743|Flavobacteriia	976|Bacteroidetes	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,PA14
k59_166669_1	42256.RradSPS_0648	1.53e-60	201.0	COG0423@1|root,COG0423@2|Bacteria,2GIT3@201174|Actinobacteria,4CP9U@84995|Rubrobacteria	84995|Rubrobacteria	J	Catalyzes the attachment of glycine to tRNA(Gly)	glyQS	-	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
k59_54545_1	324925.Ppha_1361	1.17e-28	116.0	COG1473@1|root,COG1473@2|Bacteria,1FDR4@1090|Chlorobi	1090|Chlorobi	S	peptidase dimerisation domain protein	-	-	-	ko:K01436	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
k59_1221383_1	765911.Thivi_2951	1.36e-66	208.0	COG3335@1|root,COG3335@2|Bacteria,1N5WI@1224|Proteobacteria,1S5TZ@1236|Gammaproteobacteria,1WZ05@135613|Chromatiales	135613|Chromatiales	L	COG3335 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
k59_218336_1	909663.KI867150_gene1794	7.05e-33	127.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,42MKU@68525|delta/epsilon subdivisions,2WJR3@28221|Deltaproteobacteria,2MQD2@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	PFAM UvrD REP helicase	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_218336_2	1123242.JH636434_gene3567	4.1e-18	83.6	COG1801@1|root,COG1801@2|Bacteria,2IYWM@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
k59_110277_1	580332.Slit_2212	2.59e-31	124.0	COG0457@1|root,COG0457@2|Bacteria,1P464@1224|Proteobacteria,2VMYZ@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF560)	-	-	-	-	-	-	-	-	-	-	-	-	DUF560,TPR_19
k59_554236_1	1156919.QWC_02723	3.53e-24	105.0	COG0642@1|root,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,2VIXT@28216|Betaproteobacteria,3T1D8@506|Alcaligenaceae	28216|Betaproteobacteria	T	COG0642 Signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
k59_1722541_1	1125863.JAFN01000001_gene2974	5.98e-96	290.0	COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,42M1J@68525|delta/epsilon subdivisions,2WIQR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	D	Cell shape determining protein MreB Mrl	mreB	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
k59_554292_1	1301098.PKB_4585	1.81e-33	128.0	COG1792@1|root,COG1792@2|Bacteria,1N8ZS@1224|Proteobacteria,1RMK4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Involved in formation and maintenance of cell shape	mreC	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007163,GO:0008150,GO:0008360,GO:0009987,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0043621,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944,GO:0071963	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
k59_776445_1	1408473.JHXO01000008_gene2832	9.26e-35	136.0	COG0815@1|root,COG0815@2|Bacteria,4NMJK@976|Bacteroidetes	976|Bacteroidetes	M	Carbon-nitrogen hydrolase	-	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
k59_1553856_1	1379270.AUXF01000005_gene684	1.24e-31	128.0	COG0768@1|root,COG0768@2|Bacteria,1ZSYD@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Penicillin binding protein transpeptidase domain	-	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PBP_dimer,Transpeptidase
k59_54673_1	1286106.MPL1_04562	1.07e-39	137.0	COG0597@1|root,COG0597@2|Bacteria,1RGV9@1224|Proteobacteria,1S60E@1236|Gammaproteobacteria,460TI@72273|Thiotrichales	72273|Thiotrichales	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
k59_554345_1	694429.Pyrfu_0868	3.65e-50	168.0	COG0846@1|root,arCOG04248@2157|Archaea,2XQBQ@28889|Crenarchaeota	28889|Crenarchaeota	K	form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription	cobB	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
k59_554374_1	867845.KI911784_gene2666	6.15e-39	148.0	COG2304@1|root,COG5426@1|root,COG2304@2|Bacteria,COG5426@2|Bacteria,2GBRR@200795|Chloroflexi,376B2@32061|Chloroflexia	32061|Chloroflexia	D	PFAM von Willebrand factor type A	-	-	-	-	-	-	-	-	-	-	-	-	GATase1_like,VWA,VWA_2
k59_110447_1	1210884.HG799462_gene8030	1.85e-46	164.0	COG2195@1|root,COG2195@2|Bacteria,2IXPR@203682|Planctomycetes	203682|Planctomycetes	E	Peptidase M20	-	-	3.4.11.4	ko:K01258	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
k59_389026_1	143224.JQMD01000002_gene1375	4.41e-77	251.0	COG4733@1|root,COG4733@2|Bacteria,4PKH9@976|Bacteroidetes,1IJ8W@117743|Flavobacteriia	976|Bacteroidetes	S	Concanavalin A-like lectin/glucanases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3
k59_54743_1	429009.Adeg_0321	1.09e-16	84.3	COG0438@1|root,COG0438@2|Bacteria,1TPY6@1239|Firmicutes,24834@186801|Clostridia,42FGD@68295|Thermoanaerobacterales	186801|Clostridia	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
k59_1221571_1	313603.FB2170_06440	1.16e-38	142.0	2CK9T@1|root,2Z7W9@2|Bacteria,4NH9E@976|Bacteroidetes,1I39H@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_608861_1	1068978.AMETH_5712	9.57e-61	201.0	COG0160@1|root,COG0160@2|Bacteria,2GIS9@201174|Actinobacteria,4DY9R@85010|Pseudonocardiales	201174|Actinobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	gabT2	-	2.6.1.19	ko:K00823	ko00250,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_389126_1	316067.Geob_2999	1.57e-13	73.2	COG0671@1|root,COG0671@2|Bacteria,1QUKE@1224|Proteobacteria,42XAW@68525|delta/epsilon subdivisions,2WT5A@28221|Deltaproteobacteria,43ST1@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	PFAM phosphoesterase, PA-phosphatase related	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
k59_1000392_1	991905.SL003B_2680	4.7e-24	96.3	COG0664@1|root,COG0664@2|Bacteria,1RI6M@1224|Proteobacteria,2U9WH@28211|Alphaproteobacteria,4BQJM@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	K	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
k59_1000392_2	414684.RC1_2792	8.67e-25	99.4	COG0708@1|root,COG0708@2|Bacteria,1MVMC@1224|Proteobacteria,2TRWQ@28211|Alphaproteobacteria,2JQET@204441|Rhodospirillales	204441|Rhodospirillales	L	COG0708 Exonuclease III	-	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
k59_1554072_1	414684.RC1_3203	2.24e-44	160.0	COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,2TS41@28211|Alphaproteobacteria,2JPA9@204441|Rhodospirillales	204441|Rhodospirillales	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	rpoN	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
k59_110584_1	518766.Rmar_2201	4.08e-18	86.7	COG1629@1|root,COG4771@2|Bacteria,4NDX3@976|Bacteroidetes,1FISC@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	P	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec
k59_110640_1	768671.ThimaDRAFT_4037	5.4e-93	288.0	COG3385@1|root,COG3385@2|Bacteria,1RA6A@1224|Proteobacteria,1SDJ1@1236|Gammaproteobacteria,1X0RY@135613|Chromatiales	135613|Chromatiales	L	PFAM Transposase, IS4-like	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1554152_1	1267534.KB906757_gene956	5.76e-10	65.1	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Pkinase,Trans_reg_C,WD40
k59_1000503_1	1379270.AUXF01000005_gene790	6.52e-92	284.0	COG0459@1|root,COG0459@2|Bacteria,1ZTC5@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	-	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
k59_1666075_1	1051632.TPY_1814	3.32e-58	194.0	COG1449@1|root,COG1449@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 57 family	-	-	3.2.1.1	ko:K01176,ko:K07405	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13,GH57	-	Glyco_hydro_57
k59_1000506_1	887898.HMPREF0551_0064	5.96e-49	171.0	COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,2VJ29@28216|Betaproteobacteria,1K10P@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Phosphoglucomutase phosphomannomutase, alpha beta alpha domain II	algC	GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005488,GO:0005975,GO:0005976,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009243,GO:0009244,GO:0009311,GO:0009312,GO:0009405,GO:0009987,GO:0016051,GO:0016053,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0042120,GO:0042121,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044419,GO:0046394,GO:0046401,GO:0046402,GO:0046872,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	5.4.2.2,5.4.2.8	ko:K01835,ko:K01840,ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114,M00549	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_609065_1	1408473.JHXO01000005_gene1675	3.24e-64	219.0	COG1472@1|root,COG1472@2|Bacteria,4NE90@976|Bacteroidetes,2FNZH@200643|Bacteroidia	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 3 family	bglB	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
k59_1666112_1	926569.ANT_15270	1.31e-71	238.0	COG1200@1|root,COG1200@2|Bacteria,2G5YM@200795|Chloroflexi	200795|Chloroflexi	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
k59_54997_1	1082933.MEA186_24120	0.000956	40.8	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,43NVJ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	T	COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain)	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,HEAT_2,Rhodanese,TPR_16,TPR_19,TPR_8,TolB_N
k59_947081_1	188626.HMPREF0321_2685	6.21e-44	157.0	COG2124@1|root,COG2124@2|Bacteria,2GKCG@201174|Actinobacteria	201174|Actinobacteria	Q	cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
k59_446753_1	331869.BAL199_19488	5.66e-31	123.0	COG1167@1|root,COG1167@2|Bacteria,1MUJE@1224|Proteobacteria,2TQZZ@28211|Alphaproteobacteria,4BR71@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	K	helix_turn_helix gluconate operon transcriptional repressor	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2,GntR
k59_1169428_1	136037.KDR18657	3.34e-13	75.9	KOG3567@1|root,KOG3567@2759|Eukaryota,38D77@33154|Opisthokonta,3BCSZ@33208|Metazoa,3D20Z@33213|Bilateria,41X27@6656|Arthropoda,3SJXR@50557|Insecta	33208|Metazoa	O	It is involved in the biological process described with peptide metabolic process	-	GO:0000003,GO:0002009,GO:0002165,GO:0003674,GO:0003824,GO:0004598,GO:0005575,GO:0005623,GO:0007275,GO:0007444,GO:0007472,GO:0007476,GO:0007552,GO:0007560,GO:0007610,GO:0007617,GO:0007618,GO:0007619,GO:0008150,GO:0009653,GO:0009791,GO:0009886,GO:0009887,GO:0009888,GO:0016829,GO:0016840,GO:0016842,GO:0019098,GO:0019953,GO:0022414,GO:0032501,GO:0032502,GO:0032504,GO:0035107,GO:0035114,GO:0035120,GO:0035220,GO:0035239,GO:0035295,GO:0036477,GO:0043025,GO:0044297,GO:0044464,GO:0044703,GO:0044719,GO:0048513,GO:0048563,GO:0048569,GO:0048609,GO:0048707,GO:0048729,GO:0048731,GO:0048736,GO:0048737,GO:0048856,GO:0051704,GO:0060429,GO:0060562,GO:0065007,GO:0065008,GO:0090066,GO:0097458,GO:0140096	1.14.17.3,4.3.2.5	ko:K00504,ko:K12597,ko:K18200	ko03018,map03018	M00393	-	-	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	Cu2_monoox_C,Cu2_monooxygen,NHL
k59_224291_1	573065.Astex_0873	1.65e-15	80.9	COG2885@1|root,COG3637@1|root,COG2885@2|Bacteria,COG3637@2|Bacteria,1N6EM@1224|Proteobacteria,2U17R@28211|Alphaproteobacteria,2KFB3@204458|Caulobacterales	204458|Caulobacterales	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl,OmpA
k59_1280662_1	1177928.TH2_19899	3.99e-42	141.0	COG3350@1|root,COG3350@2|Bacteria,1NI4P@1224|Proteobacteria,2UUZG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	YHS domain	-	-	-	-	-	-	-	-	-	-	-	-	YHS
k59_1280662_2	1504981.KO116_2263	1.28e-47	155.0	2E5JD@1|root,330AQ@2|Bacteria,1N86Q@1224|Proteobacteria,1SC9N@1236|Gammaproteobacteria,1XQHW@135619|Oceanospirillales	135619|Oceanospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1186400_1	1122147.AUEH01000004_gene1070	4.78e-09	61.2	COG0469@1|root,COG0469@2|Bacteria,1TPGG@1239|Firmicutes,4H9VY@91061|Bacilli,3F9ER@33958|Lactobacillaceae	91061|Bacilli	G	Pyruvate kinase, barrel domain	pyk	GO:0001871,GO:0003674,GO:0003824,GO:0004743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006116,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019674,GO:0019693,GO:0019752,GO:0030246,GO:0030247,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:2001065	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PEP-utilizers,PK,PK_C
k59_74422_2	1267533.KB906733_gene3362	2.16e-05	47.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,3Y7E7@57723|Acidobacteria,2JKGS@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
k59_464599_1	1454004.AW11_03176	1.04e-41	149.0	COG4198@1|root,COG4198@2|Bacteria,1NPPY@1224|Proteobacteria,2VM95@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF1015)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
k59_464599_2	349124.Hhal_2231	6.08e-12	65.1	COG0300@1|root,COG0300@2|Bacteria,1RGKZ@1224|Proteobacteria,1T1HV@1236|Gammaproteobacteria,1X2QM@135613|Chromatiales	135613|Chromatiales	S	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_1686873_1	857087.Metme_0419	7.94e-75	243.0	COG0472@1|root,COG0472@2|Bacteria,1MWYW@1224|Proteobacteria,1RNAP@1236|Gammaproteobacteria,1XGMG@135618|Methylococcales	135618|Methylococcales	M	Glycosyl transferase family 4	-	-	2.7.8.33,2.7.8.35	ko:K02851	-	-	R08856	RC00002	ko00000,ko01000,ko01003,ko01005	-	-	-	Glycos_transf_4
k59_1408979_1	616991.JPOO01000001_gene2849	1.54e-65	215.0	COG0591@1|root,COG0591@2|Bacteria,4NEN8@976|Bacteroidetes,1HYVB@117743|Flavobacteriia,23GJJ@178469|Arenibacter	976|Bacteroidetes	E	Sodium:solute symporter family	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
k59_797569_1	643648.Slip_2135	6.48e-75	243.0	COG0449@1|root,COG0449@2|Bacteria,1TPGU@1239|Firmicutes,248F8@186801|Clostridia,42JRY@68298|Syntrophomonadaceae	186801|Clostridia	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
k59_1243652_1	926569.ANT_06270	3.6e-154	443.0	COG0334@1|root,COG0334@2|Bacteria,2G5SR@200795|Chloroflexi	200795|Chloroflexi	C	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
k59_797577_1	234267.Acid_7161	2.53e-32	124.0	COG2159@1|root,COG2159@2|Bacteria,3Y5M2@57723|Acidobacteria	57723|Acidobacteria	E	PFAM Amidohydrolase 2	-	-	4.1.1.45	ko:K03392,ko:K07045	ko00380,ko01100,map00380,map01100	M00038	R04323	RC00779	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
k59_1408994_1	926550.CLDAP_19150	3.98e-37	140.0	COG1232@1|root,COG1232@2|Bacteria,2G687@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX	-	-	1.3.3.15,1.3.3.4	ko:K00231	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03222,R04178	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
k59_1575567_1	1380394.JADL01000001_gene2034	5.62e-35	137.0	COG1132@1|root,COG1132@2|Bacteria,1MWTY@1224|Proteobacteria,2TRSY@28211|Alphaproteobacteria,2JPPS@204441|Rhodospirillales	204441|Rhodospirillales	V	ABC transporter transmembrane region	-	-	-	ko:K02021	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21	-	-	ABC_membrane,ABC_tran,cNMP_binding
k59_964282_1	234267.Acid_6138	2.34e-47	171.0	COG0457@1|root,COG2010@1|root,COG0457@2|Bacteria,COG2010@2|Bacteria,3Y67F@57723|Acidobacteria	57723|Acidobacteria	C	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
k59_1297557_1	1403313.AXBR01000005_gene1968	3.55e-14	76.3	COG1216@1|root,COG1572@1|root,COG1216@2|Bacteria,COG1572@2|Bacteria,1V22N@1239|Firmicutes,4HKI5@91061|Bacilli,1ZF57@1386|Bacillus	91061|Bacilli	S	COG0463 Glycosyltransferases involved in cell wall biogenesis	wcaA	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_7C,Glycos_transf_2,Laminin_G_3
k59_629832_2	335283.Neut_1805	3.69e-40	140.0	COG3167@1|root,COG3167@2|Bacteria,1RBGW@1224|Proteobacteria,2VH68@28216|Betaproteobacteria,372ZW@32003|Nitrosomonadales	28216|Betaproteobacteria	NU	Pilus assembly protein, PilO	pilO	-	-	ko:K02664	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilO
k59_742000_1	572547.Amico_1243	1.18e-99	313.0	COG1554@1|root,COG1554@2|Bacteria,3TBY3@508458|Synergistetes	508458|Synergistetes	G	PFAM glycoside hydrolase family 65 central catalytic	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_65N,Glyco_hydro_65m
k59_1186437_1	396588.Tgr7_0735	8.43e-46	162.0	COG2801@1|root,COG2801@2|Bacteria,1N207@1224|Proteobacteria,1S1FB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_32,LZ_Tnp_IS481,rve,rve_3
k59_408299_1	349163.Acry_2060	2.46e-40	144.0	COG1723@1|root,COG1723@2|Bacteria,1MWYM@1224|Proteobacteria,2TU31@28211|Alphaproteobacteria,2JS0A@204441|Rhodospirillales	204441|Rhodospirillales	S	Uncharacterised ACR, YagE family COG1723	-	-	-	-	-	-	-	-	-	-	-	-	DUF155
k59_408301_2	861299.J421_2771	2.31e-61	207.0	COG0480@1|root,COG0480@2|Bacteria,1ZT9G@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_1519889_1	251229.Chro_5267	2.76e-10	67.0	COG0587@1|root,COG0587@2|Bacteria,1G0VY@1117|Cyanobacteria,3VIFR@52604|Pleurocapsales	1117|Cyanobacteria	L	PFAM OB-fold nucleic acid binding domain	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	HHH_6,tRNA_anti-codon
k59_408315_2	1185876.BN8_05815	2.35e-08	58.5	COG0662@1|root,COG0662@2|Bacteria,4NT7A@976|Bacteroidetes,47RUT@768503|Cytophagia	976|Bacteroidetes	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_1075160_1	861299.J421_3604	3.45e-49	174.0	COG1472@1|root,COG1472@2|Bacteria,1ZTD2@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Glycosyl hydrolase family 3 C-terminal domain	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3,Glyco_hydro_3_C
k59_408318_1	69279.BG36_10900	5.33e-24	94.4	COG0736@1|root,COG0736@2|Bacteria,1MZBF@1224|Proteobacteria,2U77S@28211|Alphaproteobacteria,43JYR@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
k59_408318_2	269796.Rru_A0027	7.78e-60	193.0	COG0744@1|root,COG0744@2|Bacteria,1RDAQ@1224|Proteobacteria,2U0NP@28211|Alphaproteobacteria,2JS5A@204441|Rhodospirillales	204441|Rhodospirillales	M	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors	mtgA	-	2.4.1.129	ko:K03814	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly
k59_1020414_1	526227.Mesil_2234	7.19e-08	53.1	COG0295@1|root,COG0295@2|Bacteria,1WKF5@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	F	This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis	-	-	3.5.4.5	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1
k59_1020414_2	649747.HMPREF0083_02005	3.33e-05	47.8	COG1381@1|root,COG1381@2|Bacteria,1UZ19@1239|Firmicutes,4HAHI@91061|Bacilli,26S90@186822|Paenibacillaceae	91061|Bacilli	L	Involved in DNA repair and RecF pathway recombination	recO	GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0033554,GO:0034641,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
k59_964334_1	29581.BW37_03724	2.61e-15	80.9	COG1463@1|root,COG3008@1|root,COG1463@2|Bacteria,COG3008@2|Bacteria,1MU1T@1224|Proteobacteria,2VJ44@28216|Betaproteobacteria,4725P@75682|Oxalobacteraceae	28216|Betaproteobacteria	Q	MlaD protein	pqiB	-	-	ko:K06192	-	-	-	-	ko00000	-	-	-	MlaD
k59_1464694_1	765420.OSCT_2349	1.31e-23	104.0	COG0642@1|root,COG2199@1|root,COG0642@2|Bacteria,COG3706@2|Bacteria	2|Bacteria	T	GGDEF domain	-	-	4.6.1.1	ko:K01768,ko:K20977	ko00230,ko02020,ko02025,ko04113,ko04213,map00230,map02020,map02025,map04113,map04213	M00695,M00820	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko02022	-	-	-	DUF3404,GAF,HATPase_c,HATPase_c_2,HisKA,Response_reg,SpoIIE
k59_19269_1	661478.OP10G_4014	1.92e-52	179.0	COG2873@1|root,COG2873@2|Bacteria	2|Bacteria	E	o-acetylhomoserine	metY	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
k59_686866_1	1380386.JIAW01000005_gene1572	2.47e-52	179.0	COG0010@1|root,COG0010@2|Bacteria,2GJA6@201174|Actinobacteria,234A3@1762|Mycobacteriaceae	201174|Actinobacteria	E	Belongs to the arginase family	speB	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
k59_352022_1	1123060.JONP01000022_gene1822	2.86e-25	103.0	COG0189@1|root,COG0189@2|Bacteria,1R5VK@1224|Proteobacteria,2U2DG@28211|Alphaproteobacteria,2JQMX@204441|Rhodospirillales	204441|Rhodospirillales	HJ	COG0189 Glutathione synthase Ribosomal protein S6 modification enzyme (glutaminyl transferase)	-	-	-	-	-	-	-	-	-	-	-	-	RimK
k59_352022_2	391735.Veis_4265	0.000791	44.7	COG1545@1|root,COG1545@2|Bacteria,1R44D@1224|Proteobacteria,2VV9U@28216|Betaproteobacteria,4AJFP@80864|Comamonadaceae	28216|Betaproteobacteria	S	Rubredoxin-like zinc ribbon domain (DUF35_N)	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
k59_352022_3	316056.RPC_1074	1.59e-11	63.9	COG0183@1|root,COG0183@2|Bacteria,1MUZV@1224|Proteobacteria,2TRHF@28211|Alphaproteobacteria,3JRM3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	acetyl-coa acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Thiolase_C
k59_1075201_1	224911.27348616	3.86e-40	147.0	COG2706@1|root,COG2706@2|Bacteria,1MWGS@1224|Proteobacteria,2VETU@28211|Alphaproteobacteria,3JRRP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Lactonase, 7-bladed beta-propeller	-	-	3.1.1.31	ko:K07404	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Lactonase
k59_574448_1	1237149.C900_01932	1.35e-27	109.0	2DBV7@1|root,2ZB9P@2|Bacteria,4NPQU@976|Bacteroidetes,47QI9@768503|Cytophagia	976|Bacteroidetes	S	Domain of unknown function (DUF4386)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4386
k59_74522_1	471855.Shel_05070	3.58e-38	134.0	COG0437@1|root,COG0437@2|Bacteria,2H0W0@201174|Actinobacteria	2|Bacteria	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_11,Fer4_4
k59_964369_2	395961.Cyan7425_1728	7e-18	84.0	COG1216@1|root,COG1216@2|Bacteria,1GQEZ@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_2,Glycos_transf_2
k59_408356_1	1089553.Tph_c20110	4.31e-83	261.0	COG3547@1|root,COG3547@2|Bacteria,1TQP6@1239|Firmicutes,248VD@186801|Clostridia,42FT8@68295|Thermoanaerobacterales	186801|Clostridia	L	Transposase IS116 IS110 IS902 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1243760_1	211165.AJLN01000085_gene1578	9.06e-15	74.7	COG0517@1|root,COG0517@2|Bacteria,1G5TQ@1117|Cyanobacteria,1JK44@1189|Stigonemataceae	1117|Cyanobacteria	S	CBS domain	-	-	-	ko:K07182	-	-	-	-	ko00000	-	-	-	CBS
k59_1243760_2	575564.HMPREF0014_04530	1.92e-08	52.8	COG1714@1|root,COG1714@2|Bacteria,1PRKM@1224|Proteobacteria,1SIDK@1236|Gammaproteobacteria,3NRYW@468|Moraxellaceae	1236|Gammaproteobacteria	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_909575_1	983545.Glaag_3586	2.69e-45	149.0	COG0509@1|root,COG0509@2|Bacteria,1RGV7@1224|Proteobacteria,1S656@1236|Gammaproteobacteria,466ZQ@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	GO:0001505,GO:0003674,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008289,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0017144,GO:0019464,GO:0019752,GO:0031405,GO:0031406,GO:0033293,GO:0036094,GO:0042133,GO:0042135,GO:0042737,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0048037,GO:0050662,GO:0065007,GO:0065008,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1901681	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	iE2348C_1286.E2348C_3156,iPC815.YPO0906	GCV_H
k59_797685_1	153721.MYP_3211	2.9e-28	117.0	COG0531@1|root,COG0531@2|Bacteria,4P19H@976|Bacteroidetes	976|Bacteroidetes	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
k59_1464751_1	204669.Acid345_4190	2.98e-06	54.7	COG1629@1|root,COG4771@2|Bacteria,3Y3P9@57723|Acidobacteria,2JHUB@204432|Acidobacteriia	204432|Acidobacteriia	P	PFAM TonB-dependent Receptor Plug	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
k59_519596_1	1121035.AUCH01000001_gene2013	1.39e-13	70.1	COG1024@1|root,COG1024@2|Bacteria,1MUJ7@1224|Proteobacteria,2VIP5@28216|Betaproteobacteria,2KVJJ@206389|Rhodocyclales	206389|Rhodocyclales	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
k59_519596_2	1033736.CAHK01000027_gene1609	1.34e-34	132.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4F8D6@85019|Brevibacteriaceae	201174|Actinobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_464741_1	1469245.JFBG01000012_gene893	1.97e-38	144.0	COG5598@1|root,COG5598@2|Bacteria,1N18H@1224|Proteobacteria,1SJKY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Trimethylamine methyltransferase (MTTB)	-	-	-	-	-	-	-	-	-	-	-	-	MTTB
k59_574503_1	1137271.AZUM01000002_gene2477	1.64e-33	130.0	COG1207@1|root,COG1207@2|Bacteria,2GJS1@201174|Actinobacteria,4DZZ7@85010|Pseudonocardiales	201174|Actinobacteria	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	GO:0000287,GO:0003674,GO:0003824,GO:0003977,GO:0005488,GO:0008080,GO:0008150,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0019134,GO:0022610,GO:0030260,GO:0035635,GO:0040007,GO:0043167,GO:0043169,GO:0044403,GO:0044406,GO:0044409,GO:0044419,GO:0044650,GO:0046872,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0070569	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transf_3,NTP_transferase
k59_74575_2	1150474.JQJI01000045_gene1618	1.84e-22	96.7	COG0312@1|root,COG0312@2|Bacteria,2GDC4@200918|Thermotogae	200918|Thermotogae	L	modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
k59_1243813_1	358681.BBR47_44190	2.04e-29	119.0	COG0477@1|root,COG0477@2|Bacteria,1UXX6@1239|Firmicutes,4HF8Y@91061|Bacilli,26TS2@186822|Paenibacillaceae	91061|Bacilli	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_742135_1	1123229.AUBC01000040_gene3836	1.06e-39	140.0	COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,2TS16@28211|Alphaproteobacteria,3JSGF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	IstB-like ATP binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
k59_742135_2	991905.SL003B_4075	2.02e-14	73.2	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria	1224|Proteobacteria	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_38,HTH_7,rve
k59_464769_1	443143.GM18_3946	5.5e-44	164.0	COG0243@1|root,COG0243@2|Bacteria,1R4RR@1224|Proteobacteria,42PA5@68525|delta/epsilon subdivisions,2WM0K@28221|Deltaproteobacteria,43W1I@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	qrcB	-	-	ko:K08357	ko00920,ko01120,ko02020,map00920,map01120,map02020	-	R10150	RC03109	ko00000,ko00001,ko02000	5.A.3.10	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_1353471_1	880072.Desac_1863	2.36e-65	223.0	COG0341@1|root,COG0342@1|root,COG0341@2|Bacteria,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,42M6V@68525|delta/epsilon subdivisions,2WJCI@28221|Deltaproteobacteria,2MR54@213462|Syntrophobacterales	28221|Deltaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
k59_74589_2	324602.Caur_3475	5.9e-28	110.0	COG0438@1|root,COG0438@2|Bacteria,2G84C@200795|Chloroflexi,375HH@32061|Chloroflexia	32061|Chloroflexia	M	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1,Methyltransf_11
k59_519632_1	994479.GL877883_gene7327	2.96e-83	260.0	COG0554@1|root,COG0554@2|Bacteria,2GM13@201174|Actinobacteria,4DX7A@85010|Pseudonocardiales	201174|Actinobacteria	C	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
k59_1353492_1	666685.R2APBS1_0857	3.38e-55	179.0	COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,1S3YV@1236|Gammaproteobacteria,1X41Z@135614|Xanthomonadales	135614|Xanthomonadales	K	Belongs to the UPF0301 (AlgH) family	algH	-	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
k59_629983_1	1095769.CAHF01000022_gene345	1.15e-13	75.1	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,2VINC@28216|Betaproteobacteria,47760@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
k59_629983_2	314230.DSM3645_08151	1.15e-13	73.6	COG0841@1|root,COG0841@2|Bacteria,2IYJA@203682|Planctomycetes	203682|Planctomycetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1076940_1	395495.Lcho_3543	7.67e-09	63.5	COG0642@1|root,COG0784@1|root,COG2198@1|root,COG2202@1|root,COG3829@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,COG3829@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,1KJCZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,HATPase_c,HisKA,Hpt,PAS_3,PAS_4,PAS_7,PAS_9,Response_reg
k59_1299419_1	555779.Dthio_PD0726	5.56e-42	142.0	2DMID@1|root,32RSF@2|Bacteria,1R0WM@1224|Proteobacteria,43D2G@68525|delta/epsilon subdivisions	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_76227_1	1276246.SCULI_v1c04900	6.08e-09	61.6	COG0124@1|root,COG0124@2|Bacteria,3WSVQ@544448|Tenericutes	544448|Tenericutes	J	histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
k59_1355256_1	585531.HMPREF0063_11089	1.72e-50	175.0	COG1290@1|root,COG1290@2|Bacteria,2GJ1E@201174|Actinobacteria,4DNCY@85009|Propionibacteriales	201174|Actinobacteria	C	Cytochrome b	qcrB	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K03891	ko00190,ko01100,map00190,map01100	M00151	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrom_B_N_2
k59_1355256_2	1713.JOFV01000016_gene74	3.36e-41	145.0	COG0723@1|root,COG0723@2|Bacteria,2GIX6@201174|Actinobacteria,4F0PQ@85016|Cellulomonadaceae	201174|Actinobacteria	C	PFAM Rieske 2Fe-2S iron-sulphur domain	qcrA	-	-	ko:K03890	ko00190,ko01100,map00190,map01100	M00151	-	-	ko00000,ko00001,ko00002	-	-	-	Rieske
k59_1355264_1	1121123.AUAO01000003_gene2224	2.91e-30	118.0	COG2010@1|root,COG2010@2|Bacteria,1NEUK@1224|Proteobacteria,2UIJ4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
k59_1299443_1	379066.GAU_2148	4.38e-78	260.0	COG1197@1|root,COG1197@2|Bacteria,1ZT88@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_1410771_1	1304865.JAGF01000001_gene1406	2.79e-22	94.0	COG2141@1|root,COG2141@2|Bacteria,2HGTQ@201174|Actinobacteria	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_1410771_2	1444310.JANV01000114_gene4540	4.27e-15	75.5	COG1108@1|root,COG1108@2|Bacteria,1TPZB@1239|Firmicutes,4HBD7@91061|Bacilli,1ZAY6@1386|Bacillus	91061|Bacilli	P	'COG1108 ABC-type Mn2 Zn2 transport systems, permease components'	mntD	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0010035,GO:0010038,GO:0010043,GO:0016020,GO:0042221,GO:0044464,GO:0050896,GO:0071944	-	ko:K11709,ko:K19976	ko02010,map02010	M00319,M00792	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15,3.A.1.15.15	-	-	ABC-3
k59_1743851_1	706587.Desti_3108	5.62e-56	188.0	COG3635@1|root,COG3635@2|Bacteria,1R4TM@1224|Proteobacteria,43DQP@68525|delta/epsilon subdivisions,2X6VW@28221|Deltaproteobacteria,2MR1H@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	2,3-bisphosphoglycerate-independent phosphoglycerate mutase	-	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
k59_410040_1	1183438.GKIL_0015	3.75e-70	231.0	COG0021@1|root,COG0021@2|Bacteria,1G0GC@1117|Cyanobacteria	1117|Cyanobacteria	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tktA	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
k59_298839_1	1232410.KI421421_gene3444	1.14e-85	260.0	COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,42M2W@68525|delta/epsilon subdivisions,2WJBV@28221|Deltaproteobacteria,43TQR@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,CoA_binding,Ligase_CoA
k59_640835_1	643562.Daes_0278	4.97e-29	117.0	28HAQ@1|root,2Z7N0@2|Bacteria,1N5R2@1224|Proteobacteria,42YEC@68525|delta/epsilon subdivisions,2WTJ4@28221|Deltaproteobacteria,2MB66@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2157
k59_252246_1	926569.ANT_27710	5.02e-62	209.0	COG2010@1|root,COG3391@1|root,COG2010@2|Bacteria,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	nirS	GO:0005575,GO:0005623,GO:0042597,GO:0044464	1.7.2.1,1.7.99.1	ko:K15864	ko00910,ko01120,map00910,map01120	M00529	R00143,R00783,R00785	RC00086,RC02797	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytochrom_C,Cytochrom_D1,Cytochrome_CBB3,GSDH
k59_252251_1	768671.ThimaDRAFT_3899	1.12e-17	82.4	COG1409@1|root,COG1409@2|Bacteria,1MWKX@1224|Proteobacteria,1RPA7@1236|Gammaproteobacteria,1WXST@135613|Chromatiales	135613|Chromatiales	S	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes	cpdA	-	3.1.4.53	ko:K03651	ko00230,ko02025,map00230,map02025	-	R00191	RC00296	ko00000,ko00001,ko01000	-	-	-	Metallophos
k59_252251_2	314278.NB231_01209	6.2e-29	114.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,1RMWP@1236|Gammaproteobacteria,1WVWH@135613|Chromatiales	135613|Chromatiales	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
k59_1476382_1	1123288.SOV_1c02140	8.65e-34	133.0	COG2233@1|root,COG2233@2|Bacteria,1TNZZ@1239|Firmicutes,4H7WA@909932|Negativicutes	909932|Negativicutes	F	Permease family	-	-	-	-	-	-	-	-	-	-	-	-	Xan_ur_permease
k59_1087114_1	926550.CLDAP_39000	3.4e-14	72.8	COG1595@1|root,COG1595@2|Bacteria,2G6X7@200795|Chloroflexi	200795|Chloroflexi	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4
k59_585672_2	69042.WH5701_09920	8.43e-60	194.0	COG3335@1|root,COG3335@2|Bacteria,1G60T@1117|Cyanobacteria,1H3RV@1129|Synechococcus	1117|Cyanobacteria	L	COG3335 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_23
k59_1310073_1	1121861.KB899940_gene3730	1.81e-71	233.0	COG5476@1|root,COG5476@2|Bacteria,1MX4P@1224|Proteobacteria,2TS1C@28211|Alphaproteobacteria,2JPFT@204441|Rhodospirillales	204441|Rhodospirillales	S	Involved in peptidolytic degradation of cyclic heptapeptide hepatotoxin microcystin (MC)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1485,MlrC_C
k59_1087130_1	55601.VANGNB10_cII0498	3.5e-48	166.0	COG2826@1|root,COG2826@2|Bacteria,1MWI0@1224|Proteobacteria,1RRSE@1236|Gammaproteobacteria,1XW0E@135623|Vibrionales	135623|Vibrionales	L	other refs with uncharged polar side chains (S Ser or T Thr), and there are a few more such examples along the aa-chain (ex R Arg changed with H His)	-	-	-	-	-	-	-	-	-	-	-	-	HTH_38,rve
k59_1310084_1	525897.Dbac_2170	1.85e-25	99.0	COG2823@1|root,COG2823@2|Bacteria,1N0SU@1224|Proteobacteria,42VD3@68525|delta/epsilon subdivisions,2WRQJ@28221|Deltaproteobacteria,2MDDZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	SMART Transport-associated and nodulation region	-	-	-	-	-	-	-	-	-	-	-	-	BON
k59_640879_1	1158292.JPOE01000002_gene1874	5.79e-22	97.4	COG0577@1|root,COG1136@1|root,COG0577@2|Bacteria,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,2VHZ2@28216|Betaproteobacteria,1KPMQ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	V	membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides	macB	-	-	ko:K02003,ko:K05685	ko02010,map02010	M00258,M00709	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.122.1,3.A.1.122.12	-	-	ABC_tran,FtsX,MacB_PCD
k59_1255285_1	1307761.L21SP2_1483	1.25e-104	310.0	COG3638@1|root,COG3638@2|Bacteria,2J6UW@203691|Spirochaetes	203691|Spirochaetes	P	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system	phnC	-	3.6.3.28	ko:K02041	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.9	-	-	ABC_tran
k59_922146_1	1095772.CAHH01000028_gene2564	3.06e-21	92.0	COG4559@1|root,COG4559@2|Bacteria,2GMUI@201174|Actinobacteria	201174|Actinobacteria	P	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system	hmuV	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
k59_1531057_1	385682.AFSL01000063_gene1514	1.67e-67	221.0	COG1660@1|root,COG3178@1|root,COG1660@2|Bacteria,COG3178@2|Bacteria,4NIT0@976|Bacteroidetes,2FMEM@200643|Bacteroidia,3XJI6@558415|Marinilabiliaceae	976|Bacteroidetes	S	P-loop ATPase protein family	-	-	-	-	-	-	-	-	-	-	-	-	APH,ATP_bind_2
k59_1197924_1	580340.Tlie_0056	1.62e-17	88.2	COG1615@1|root,COG1615@2|Bacteria,3TANI@508458|Synergistetes	508458|Synergistetes	S	UPF0182 protein	-	-	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
k59_252297_1	143224.JQMD01000002_gene2503	1.72e-59	207.0	COG4888@1|root,COG4888@2|Bacteria,4NEE8@976|Bacteroidetes,1HX4C@117743|Flavobacteriia	976|Bacteroidetes	S	PFAM ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
k59_976721_1	795666.MW7_3225	3.04e-54	171.0	COG0051@1|root,COG0051@2|Bacteria,1RGWF@1224|Proteobacteria,2VSDQ@28216|Betaproteobacteria,1K7MU@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Involved in the binding of tRNA to the ribosomes	rpsJ	-	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
k59_30338_1	443143.GM18_3946	4.74e-23	104.0	COG0243@1|root,COG0243@2|Bacteria,1R4RR@1224|Proteobacteria,42PA5@68525|delta/epsilon subdivisions,2WM0K@28221|Deltaproteobacteria,43W1I@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	qrcB	-	-	ko:K08357	ko00920,ko01120,ko02020,map00920,map01120,map02020	-	R10150	RC03109	ko00000,ko00001,ko02000	5.A.3.10	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_1531071_1	1380394.JADL01000017_gene479	2.15e-93	288.0	COG0154@1|root,COG0154@2|Bacteria,1MW3Z@1224|Proteobacteria,2TS56@28211|Alphaproteobacteria,2JR2A@204441|Rhodospirillales	204441|Rhodospirillales	J	Amidase	-	-	-	-	-	-	-	-	-	-	-	-	Amidase
k59_922164_1	1121934.AUDX01000001_gene2369	2.52e-31	128.0	COG0369@1|root,COG0493@1|root,COG2124@1|root,COG0369@2|Bacteria,COG0493@2|Bacteria,COG2124@2|Bacteria,2GKKN@201174|Actinobacteria,4FMCJ@85023|Microbacteriaceae	201174|Actinobacteria	EPQ	Flavodoxin	-	-	1.14.15.13	ko:K17474,ko:K21034	-	-	-	-	ko00000,ko00199,ko01000	-	-	-	Flavodoxin_1,Pyr_redox_2,p450
k59_698496_1	616991.JPOO01000001_gene3136	1.21e-25	105.0	COG1216@1|root,COG1216@2|Bacteria,4PMN7@976|Bacteroidetes,1IJVF@117743|Flavobacteriia	976|Bacteroidetes	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_1255317_1	1173028.ANKO01000154_gene4744	1.85e-55	179.0	COG0245@1|root,COG0245@2|Bacteria,1G4Z2@1117|Cyanobacteria,1HAMU@1150|Oscillatoriales	1117|Cyanobacteria	I	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	4.6.1.12	ko:K01770	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	YgbB
k59_640912_2	1203554.HMPREF1476_02207	4.76e-22	96.7	COG1947@1|root,COG1947@2|Bacteria,1MVU3@1224|Proteobacteria,2VHK3@28216|Betaproteobacteria,4PQUY@995019|Sutterellaceae	28216|Betaproteobacteria	F	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	-	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
k59_1420171_1	926569.ANT_04710	1.58e-79	253.0	COG3845@1|root,COG3845@2|Bacteria,2G68B@200795|Chloroflexi	200795|Chloroflexi	S	ATPases associated with a variety of cellular activities	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
k59_752935_1	1079460.ATTQ01000001_gene5759	1.7e-61	204.0	COG0633@1|root,COG2114@1|root,COG2146@1|root,COG0633@2|Bacteria,COG2114@2|Bacteria,COG2146@2|Bacteria,1N5XC@1224|Proteobacteria	1224|Proteobacteria	CT	Adenylyl cyclase class-3 4 guanylyl cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Fer2,Guanylate_cyc,Rieske
k59_1143334_1	1463920.JOGB01000073_gene1400	2.43e-11	69.3	COG0265@1|root,COG2319@1|root,COG0265@2|Bacteria,COG2319@2|Bacteria,2GJN3@201174|Actinobacteria	201174|Actinobacteria	F	WD-40 repeat	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin_2,WD40
k59_530822_2	589924.Ferp_1405	1.22e-32	118.0	COG1051@1|root,arCOG01075@2157|Archaea,2XXS4@28890|Euryarchaeota,2466W@183980|Archaeoglobi	183980|Archaeoglobi	L	PFAM NUDIX hydrolase	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
k59_30407_1	573.JG24_24485	1.72e-16	77.0	COG0454@1|root,COG0456@2|Bacteria,1MZQ5@1224|Proteobacteria,1S45R@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	acetyltransferase	yiaC	-	-	ko:K03826	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_10,Acetyltransf_7
k59_196713_1	926569.ANT_25050	6.94e-170	491.0	COG0443@1|root,COG0443@2|Bacteria,2G5U5@200795|Chloroflexi	200795|Chloroflexi	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
k59_1255402_1	926550.CLDAP_08640	1.39e-20	95.5	COG1388@1|root,COG1506@1|root,COG1388@2|Bacteria,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF2920,FecR,LysM,Peptidase_S9
k59_1087277_1	118168.MC7420_8322	1.15e-10	67.8	COG4252@1|root,COG4252@2|Bacteria,1GPUD@1117|Cyanobacteria,1H8M8@1150|Oscillatoriales	1117|Cyanobacteria	T	Transmembrane sensor domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE2,TIR_2
k59_419712_1	309807.SRU_1137	2.55e-110	335.0	COG1757@1|root,COG1757@2|Bacteria,4NHP9@976|Bacteroidetes,1FIXG@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	C	Na H antiporter	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_antiporter
k59_30451_1	1463887.KL589989_gene2193	1e-20	94.7	COG0477@1|root,COG2814@2|Bacteria,2ID9K@201174|Actinobacteria	201174|Actinobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1699558_1	1123366.TH3_09170	4.08e-108	323.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,2TRPK@28211|Alphaproteobacteria,2JQGR@204441|Rhodospirillales	204441|Rhodospirillales	E	Aminotransferase	aatA	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_141012_1	452637.Oter_2071	6.98e-91	286.0	COG0843@1|root,COG0843@2|Bacteria,46S4Q@74201|Verrucomicrobia,3K7EE@414999|Opitutae	414999|Opitutae	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_1476564_1	107635.AZUO01000005_gene4309	1.31e-94	292.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2TRXG@28211|Alphaproteobacteria,370BU@31993|Methylocystaceae	28211|Alphaproteobacteria	L	Transposase DDE domain	-	-	-	ko:K07487	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_363655_1	518766.Rmar_1087	7.9e-07	53.9	2DBWZ@1|root,2ZBKJ@2|Bacteria,4NMS8@976|Bacteroidetes,1FK4J@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	HmuY protein	-	-	-	-	-	-	-	-	-	-	-	-	HmuY
k59_1198070_1	1236542.BALM01000020_gene1634	6.2e-09	62.0	COG0318@1|root,COG0318@2|Bacteria,1MW0Y@1224|Proteobacteria,1RN35@1236|Gammaproteobacteria,2QAD1@267890|Shewanellaceae	1236|Gammaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	menE	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006732,GO:0008150,GO:0008152,GO:0008756,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016043,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0022607,GO:0042180,GO:0042181,GO:0042802,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901576,GO:1901661,GO:1901663	6.2.1.26	ko:K00666,ko:K01911	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R04030	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iECNA114_1301.ECNA114_2354,iECSF_1327.ECSF_2141,iEcE24377_1341.EcE24377A_2556,iEcHS_1320.EcHS_A2406,iLF82_1304.LF82_1314,iNRG857_1313.NRG857_11465	AMP-binding,AMP-binding_C
k59_309151_1	82654.Pse7367_1703	8.23e-39	150.0	COG2843@1|root,COG2843@2|Bacteria,1G0W8@1117|Cyanobacteria,1H82Y@1150|Oscillatoriales	1117|Cyanobacteria	M	of poly-gamma-glutamate biosynthesis (Capsule	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
k59_863176_1	395019.Bmul_0189	2.05e-32	126.0	COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,2VKD6@28216|Betaproteobacteria,1K2MR@119060|Burkholderiaceae	28216|Betaproteobacteria	L	PFAM transposase mutator type	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_86006_1	1121033.AUCF01000004_gene5068	5.63e-58	192.0	COG0223@1|root,COG0223@2|Bacteria,1N59R@1224|Proteobacteria,2UIHM@28211|Alphaproteobacteria,2JYNE@204441|Rhodospirillales	204441|Rhodospirillales	J	Formyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Formyl_trans_N
k59_1641366_1	861299.J421_6359	2.21e-46	172.0	COG0577@1|root,COG0577@2|Bacteria	861299.J421_6359|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1420319_1	747365.Thena_1785	1.72e-53	181.0	COG1566@1|root,COG1566@2|Bacteria,1V1F5@1239|Firmicutes,24DZ2@186801|Clostridia,42H8Z@68295|Thermoanaerobacterales	186801|Clostridia	V	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	ko:K03543	-	M00701	-	-	ko00000,ko00002,ko02000	8.A.1.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
k59_698657_1	187272.Mlg_0715	1.43e-83	255.0	COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,1RMN0@1236|Gammaproteobacteria,1WWI6@135613|Chromatiales	135613|Chromatiales	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
k59_1035365_1	349124.Hhal_0136	5.16e-69	219.0	COG0491@1|root,COG0491@2|Bacteria,1MXKX@1224|Proteobacteria,1RR31@1236|Gammaproteobacteria,1WXBJ@135613|Chromatiales	135613|Chromatiales	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_1754781_1	2754.EH55_10230	8.4e-48	169.0	COG3359@1|root,COG3359@2|Bacteria,3TATQ@508458|Synergistetes	508458|Synergistetes	L	RNase_H superfamily	-	-	-	ko:K07502	-	-	-	-	ko00000	-	-	-	RNase_H_2
k59_1035394_1	314345.SPV1_14164	1.08e-60	202.0	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria	1224|Proteobacteria	P	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
k59_32388_2	1131269.AQVV01000012_gene2570	1.23e-12	67.0	COG3267@1|root,COG3267@2|Bacteria	2|Bacteria	-	-	exeA	-	-	ko:K02450	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22,PG_binding_1
k59_1701816_1	243231.GSU2599	1.38e-152	439.0	COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,42NNQ@68525|delta/epsilon subdivisions,2WM2H@28221|Deltaproteobacteria,43TYM@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1257560_1	67275.JOAP01000013_gene5054	1.52e-43	159.0	COG1032@1|root,COG1032@2|Bacteria,2GZ25@201174|Actinobacteria	201174|Actinobacteria	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
k59_1200110_1	1238182.C882_1563	6.65e-30	116.0	COG2197@1|root,COG2197@2|Bacteria,1R7XB@1224|Proteobacteria,2U95M@28211|Alphaproteobacteria,2JSMT@204441|Rhodospirillales	204441|Rhodospirillales	T	helix_turn_helix, Lux Regulon	-	-	-	ko:K07684	ko02020,map02020	M00471	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
k59_979039_1	1536773.R70331_27660	1.73e-74	247.0	COG1554@1|root,COG1554@2|Bacteria,1TPKN@1239|Firmicutes,4HCCF@91061|Bacilli,26QVY@186822|Paenibacillaceae	91061|Bacilli	G	alpha-L-fucosidase	-	-	3.2.1.51	ko:K15923	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000	-	GH95	-	Glyco_hyd_65N_2
k59_1257570_1	926569.ANT_14120	9.66e-33	128.0	COG2271@1|root,COG2271@2|Bacteria	2|Bacteria	G	transmembrane transporter activity	-	-	-	ko:K05820	-	-	-	-	ko00000,ko02000	2.A.1.27	-	-	Acatn,MFS_1
k59_979046_1	867903.ThesuDRAFT_00468	2.8e-16	81.6	COG0593@1|root,COG0593@2|Bacteria,1TPV7@1239|Firmicutes,2490S@186801|Clostridia,3WCSH@538999|Clostridiales incertae sedis	186801|Clostridia	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
k59_1754808_1	552811.Dehly_0642	6.51e-40	146.0	COG0303@1|root,COG0303@2|Bacteria,2G6F6@200795|Chloroflexi	200795|Chloroflexi	H	MoeA domain protein domain I and II	-	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
k59_143060_1	1121481.AUAS01000005_gene2051	1.35e-28	118.0	COG3127@1|root,COG3127@2|Bacteria,4NF16@976|Bacteroidetes,47MB7@768503|Cytophagia	976|Bacteroidetes	Q	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_1533408_1	33876.JNXY01000016_gene6983	1.54e-12	70.1	COG2421@1|root,COG2421@2|Bacteria,2HQSF@201174|Actinobacteria,4DI5P@85008|Micromonosporales	201174|Actinobacteria	C	Acetamidase/Formamidase family	-	-	-	-	-	-	-	-	-	-	-	-	FmdA_AmdA
k59_700809_2	1307759.JOMJ01000003_gene1087	4.52e-77	241.0	COG1793@1|root,COG1793@2|Bacteria,1NTIR@1224|Proteobacteria	1224|Proteobacteria	L	DNA ligase	ligD	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
k59_1422468_1	546267.NEIPOLOT_01854	1.12e-35	126.0	COG2009@1|root,COG2009@2|Bacteria,1RIGZ@1224|Proteobacteria,2VSEG@28216|Betaproteobacteria,2KRHJ@206351|Neisseriales	206351|Neisseriales	C	Succinate dehydrogenase, cytochrome b556 subunit	sdhC	-	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
k59_1422468_2	365046.Rta_28090	3.08e-30	110.0	COG2142@1|root,COG2142@2|Bacteria,1MZR9@1224|Proteobacteria,2VSJN@28216|Betaproteobacteria,4AEP5@80864|Comamonadaceae	28216|Betaproteobacteria	C	TIGRFAM Succinate dehydrogenase, hydrophobic membrane anchor	sdhD	-	-	ko:K00242	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
k59_642946_1	1289387.AUKW01000003_gene2700	3.13e-16	79.7	COG0180@1|root,COG0180@2|Bacteria,2GJ9A@201174|Actinobacteria	201174|Actinobacteria	J	Tryptophanyl-tRNA synthetase	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
k59_924465_1	1101195.Meth11DRAFT_1563	3.62e-57	189.0	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,2VHUC@28216|Betaproteobacteria,2KKW1@206350|Nitrosomonadales	206350|Nitrosomonadales	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
k59_1159036_1	398720.MED217_01580	6.16e-38	142.0	COG5000@1|root,COG5000@2|Bacteria,4NEWF@976|Bacteroidetes,1HYPN@117743|Flavobacteriia,2XI7T@283735|Leeuwenhoekiella	976|Bacteroidetes	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
k59_101158_1	400668.Mmwyl1_1881	8.74e-87	280.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,1RN5I@1236|Gammaproteobacteria,1XHDB@135619|Oceanospirillales	135619|Oceanospirillales	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	acnA	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k59_1602553_1	1047013.AQSP01000044_gene248	2.58e-107	339.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
k59_1435362_1	1500301.JQMF01000007_gene1484	3.27e-13	77.0	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,2TRQG@28211|Alphaproteobacteria,4B7IS@82115|Rhizobiaceae	28211|Alphaproteobacteria	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N
k59_44552_1	1459636.NTE_01395	2.04e-102	306.0	COG2132@1|root,arCOG03914@2157|Archaea,41S77@651137|Thaumarchaeota	651137|Thaumarchaeota	Q	PFAM Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase_2,Cu-oxidase_3
k59_879077_1	1301098.PKB_3068	1.86e-23	105.0	COG1680@1|root,COG3876@1|root,COG1680@2|Bacteria,COG3876@2|Bacteria,1MVPR@1224|Proteobacteria,1RRTD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	COG1680 Beta-lactamase class C and other penicillin binding proteins	estB	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_434469_2	1123393.KB891316_gene2013	1.33e-48	155.0	COG0025@1|root,COG0025@2|Bacteria,1QTZ5@1224|Proteobacteria,2WGIC@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Zn-finger in ubiquitin-hydrolases and other protein	-	-	-	-	-	-	-	-	-	-	-	-	zf-UBP
k59_492862_1	240292.Ava_3819	2.3e-08	60.5	COG0642@1|root,COG0784@1|root,COG2202@1|root,COG3829@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,COG3829@2|Bacteria,1G09B@1117|Cyanobacteria,1HIN7@1161|Nostocales	1117|Cyanobacteria	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	DUF4118,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
k59_1159087_1	589865.DaAHT2_0795	1.82e-43	154.0	COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,42N69@68525|delta/epsilon subdivisions,2WIUJ@28221|Deltaproteobacteria,2MJ4T@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Fer4_14,Radical_SAM
k59_1380791_1	1415779.JOMH01000001_gene2583	5.58e-116	348.0	COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,1RMP2@1236|Gammaproteobacteria,1X4TP@135614|Xanthomonadales	135614|Xanthomonadales	E	Belongs to the IlvD Edd family	-	-	-	-	-	-	-	-	-	-	-	-	ILVD_EDD
k59_1656290_1	870187.Thini_3266	2.74e-48	163.0	COG0157@1|root,COG0157@2|Bacteria,1MW0C@1224|Proteobacteria,1RMBU@1236|Gammaproteobacteria,45ZNU@72273|Thiotrichales	72273|Thiotrichales	H	Belongs to the NadC ModD family	nadC	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
k59_266287_1	543728.Vapar_3471	4.63e-36	132.0	COG1802@1|root,COG1802@2|Bacteria,1MY2M@1224|Proteobacteria,2VK5T@28216|Betaproteobacteria,4ADUT@80864|Comamonadaceae	28216|Betaproteobacteria	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
k59_101230_1	570967.JMLV01000007_gene914	4.11e-56	190.0	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,2TRPX@28211|Alphaproteobacteria,2JPKV@204441|Rhodospirillales	204441|Rhodospirillales	P	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA	-	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
k59_600371_1	305900.GV64_21835	1.34e-55	188.0	COG1875@1|root,COG1875@2|Bacteria,1MUX1@1224|Proteobacteria,1RMQN@1236|Gammaproteobacteria,1XHDG@135619|Oceanospirillales	135619|Oceanospirillales	T	ATPase related to phosphate starvation-inducible protein PhoH	phoH1	-	-	ko:K07175	-	-	-	-	ko00000	-	-	-	PIN_4,PhoH
k59_156464_1	479432.Sros_4819	1.37e-30	123.0	COG2132@1|root,COG2132@2|Bacteria,2GMJ4@201174|Actinobacteria,4ENBU@85012|Streptosporangiales	201174|Actinobacteria	Q	Multicopper oxidase	-	-	1.3.3.5	ko:K08100	ko00860,ko01110,map00860,map01110	-	R02394	RC01983	ko00000,ko00001,ko01000	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
k59_492923_2	1121434.AULY01000007_gene1328	6.48e-18	85.5	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJN5@28221|Deltaproteobacteria,2MG2T@213115|Desulfovibrionales	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_44617_1	765912.Thimo_0251	4.44e-59	191.0	COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,1RZ7Y@1236|Gammaproteobacteria,1WXDP@135613|Chromatiales	135613|Chromatiales	C	PFAM thiamine pyrophosphate enzyme	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
k59_44617_2	765912.Thimo_0250	9.38e-10	59.3	COG0674@1|root,COG0674@2|Bacteria,1NBSJ@1224|Proteobacteria,1S0WV@1236|Gammaproteobacteria,1WXU8@135613|Chromatiales	135613|Chromatiales	C	oxidoreductase, alpha subunit	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR,POR_N,Transketolase_C
k59_210156_1	326427.Cagg_0382	6.08e-105	316.0	COG1883@1|root,COG1883@2|Bacteria,2G7ZJ@200795|Chloroflexi,3768I@32061|Chloroflexia	32061|Chloroflexia	C	PFAM Na transporting methylmalonyl-CoA oxaloacetate decarboxylase beta subunit	-	-	4.1.1.3	ko:K01572	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	OAD_beta
k59_1048371_2	1379698.RBG1_1C00001G0513	2.54e-13	69.7	COG0119@1|root,COG0119@2|Bacteria,2NNNZ@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA3	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
k59_767427_1	1396141.BATP01000016_gene2778	4.09e-25	110.0	COG0642@1|root,COG2203@1|root,COG4191@1|root,COG4585@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria,COG4191@2|Bacteria,COG4585@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K13040	ko02020,map02020	M00514	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	GAF,GAF_2,HATPase_c,HATPase_c_2,HisKA,HisKA_2,HisKA_3,PAS,PAS_3,PAS_4,PAS_9,Response_reg
k59_1656338_1	935866.JAER01000007_gene361	3.49e-129	379.0	COG0638@1|root,COG0638@2|Bacteria,2GMC6@201174|Actinobacteria,4DPF1@85009|Propionibacteriales	201174|Actinobacteria	O	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine	pafA	GO:0000166,GO:0000302,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006464,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0016020,GO:0016740,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019787,GO:0019941,GO:0030163,GO:0030312,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034599,GO:0034614,GO:0035639,GO:0035690,GO:0036094,GO:0036211,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044464,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070490,GO:0070647,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097159,GO:0097366,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170	6.3.1.19	ko:K13571	-	M00342	R11207	RC00090,RC00096	ko00000,ko00002,ko01000,ko03051	-	-	-	Pup_ligase
k59_1380848_1	933262.AXAM01000077_gene1703	1.56e-45	164.0	COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,42NWZ@68525|delta/epsilon subdivisions,2WJU7@28221|Deltaproteobacteria,2MJ2C@213118|Desulfobacterales	28221|Deltaproteobacteria	P	PFAM TrkA-N domain	trkA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
k59_823884_1	401526.TcarDRAFT_0814	1.02e-20	97.4	COG2199@1|root,COG3706@2|Bacteria,1VADD@1239|Firmicutes,4H8UN@909932|Negativicutes	909932|Negativicutes	T	PFAM GGDEF domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_3,GGDEF,MASE3
k59_545806_1	1286632.P278_21990	1.18e-18	85.9	COG3808@1|root,COG3808@2|Bacteria,4NF2I@976|Bacteroidetes,1HWN8@117743|Flavobacteriia	976|Bacteroidetes	C	Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase,OmpA
k59_545806_2	937777.Deipe_1215	3.57e-29	115.0	COG0624@1|root,COG0624@2|Bacteria,1WJ84@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	PFAM Peptidase family M20 M25 M40	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
k59_1380854_1	469383.Cwoe_2408	1.47e-36	138.0	COG0277@1|root,COG0277@2|Bacteria,2GK5U@201174|Actinobacteria,4CRYD@84995|Rubrobacteria	84995|Rubrobacteria	C	PFAM FAD linked oxidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
k59_101278_1	29581.BW37_01682	5.22e-83	260.0	COG2986@1|root,COG2986@2|Bacteria,1MU6K@1224|Proteobacteria,2VJB1@28216|Betaproteobacteria,4731V@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Aromatic amino acid lyase	hutH2	GO:0003674,GO:0003824,GO:0016829,GO:0016840,GO:0016841,GO:0016853,GO:0016866,GO:0016869,GO:0050368	4.3.1.23,4.3.1.3	ko:K01745,ko:K10774	ko00340,ko00350,ko01100,map00340,map00350,map01100	M00045	R00737,R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
k59_434557_1	1089547.KB913013_gene1063	1.1e-55	185.0	COG2321@1|root,COG2321@2|Bacteria,4NDTZ@976|Bacteroidetes,47KPT@768503|Cytophagia	976|Bacteroidetes	S	Putative neutral zinc metallopeptidase	ypfJ	-	-	ko:K07054	-	-	-	-	ko00000	-	-	-	Zn_peptidase
k59_938321_1	246197.MXAN_6299	3.54e-53	183.0	COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,42N30@68525|delta/epsilon subdivisions,2WJSW@28221|Deltaproteobacteria,2YUEU@29|Myxococcales	28221|Deltaproteobacteria	G	Belongs to the pyruvate kinase family	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
k59_1767795_1	941824.TCEL_00219	2.53e-05	47.0	COG3279@1|root,COG3279@2|Bacteria,1V14X@1239|Firmicutes,24BG9@186801|Clostridia,36E97@31979|Clostridiaceae	186801|Clostridia	KT	response regulator	-	-	-	ko:K02477,ko:K07705	ko02020,map02020	M00492	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	LytTR,Response_reg
k59_1380863_1	1380394.JADL01000005_gene5676	3.86e-57	187.0	COG2175@1|root,COG2175@2|Bacteria,1MVI6@1224|Proteobacteria,2TVHF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	PFAM Taurine catabolism dioxygenase TauD, TfdA family	-	-	-	-	-	-	-	-	-	-	-	-	TauD
k59_379391_1	330214.NIDE1172	4.02e-66	222.0	COG1805@1|root,COG4402@1|root,COG1805@2|Bacteria,COG4402@2|Bacteria	2|Bacteria	S	Uncharacterized protein conserved in bacteria (DUF2330)	nqrB	GO:0000166,GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008137,GO:0008144,GO:0008150,GO:0008152,GO:0010181,GO:0015672,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0019842,GO:0030001,GO:0030964,GO:0032553,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0044425,GO:0044464,GO:0048037,GO:0050136,GO:0050662,GO:0051179,GO:0051234,GO:0055114,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:1901265,GO:1901363,GO:1902444,GO:1902494	1.6.5.8	ko:K00347,ko:K21163	ko01059,ko01130,map01059,map01130	M00824	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF2330,NQR2_RnfD_RnfE
k59_1767809_1	1121447.JONL01000001_gene682	1.59e-65	223.0	COG0506@1|root,COG1012@1|root,COG0506@2|Bacteria,COG1012@2|Bacteria,1MV93@1224|Proteobacteria,42MQH@68525|delta/epsilon subdivisions,2WJPV@28221|Deltaproteobacteria,2M8WP@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Oxidizes proline to glutamate for use as a carbon and nitrogen source	putA	-	1.2.1.88,1.5.5.2	ko:K13821	ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130	-	R00245,R00707,R00708,R01253,R04444,R04445,R05051	RC00080,RC00083,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000,ko03000	-	-	iAF987.Gmet_3512	Aldedh,Pro_dh
k59_879198_1	525904.Tter_1614	3.21e-28	119.0	COG0768@1|root,COG0768@2|Bacteria,2NNWR@2323|unclassified Bacteria	2|Bacteria	M	Penicillin-binding Protein dimerisation domain	ftsI	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008144,GO:0008150,GO:0008658,GO:0008955,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0031224,GO:0031226,GO:0031406,GO:0032153,GO:0033218,GO:0033293,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043177,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051301,GO:0071944,GO:0097159,GO:1901363,GO:1901681	3.4.16.4	ko:K03587,ko:K08384	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	iSSON_1240.SSON_0092	PASTA,PBP_dimer,Transpeptidase
k59_1212999_2	1282876.BAOK01000002_gene892	9.93e-10	60.1	COG0477@1|root,COG0477@2|Bacteria,1R02N@1224|Proteobacteria,2TYHV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_379406_1	1249627.D779_3075	1e-122	361.0	COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,1RN6U@1236|Gammaproteobacteria,1WW2C@135613|Chromatiales	135613|Chromatiales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_714755_1	1370122.JHXQ01000017_gene787	0.000191	49.3	COG0747@1|root,COG0747@2|Bacteria,1MWR7@1224|Proteobacteria,2TS51@28211|Alphaproteobacteria,4BB0H@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	ABC-type dipeptide transport system, periplasmic component	dppAch2	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_1159252_1	517418.Ctha_0621	1.95e-20	95.9	COG0795@1|root,COG0795@2|Bacteria,1FDPG@1090|Chlorobi	1090|Chlorobi	S	PFAM permease YjgP YjgQ family protein	-	-	-	ko:K07091	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
k59_101324_1	936572.HMPREF1148_1580	4.59e-20	90.9	COG0111@1|root,COG2150@1|root,COG0111@2|Bacteria,COG2150@2|Bacteria,1V410@1239|Firmicutes,4H2KQ@909932|Negativicutes	909932|Negativicutes	E	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
k59_101324_2	379066.GAU_0192	2e-14	73.6	COG0075@1|root,COG0075@2|Bacteria,1ZTF3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
k59_1048428_1	251221.35211835	5.09e-19	91.3	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_103509_1	66897.DJ64_30790	8.31e-16	75.5	COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria	201174|Actinobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_103509_2	749927.AMED_0044	1.16e-11	69.3	COG4585@1|root,COG4585@2|Bacteria,2GMMU@201174|Actinobacteria,4DYS4@85010|Pseudonocardiales	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,Sensor
k59_1383278_1	580331.Thit_1010	2.96e-50	172.0	COG0343@1|root,COG0343@2|Bacteria,1TNZ4@1239|Firmicutes,247NJ@186801|Clostridia,42EMN@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
k59_1770222_1	926569.ANT_12610	3.5e-29	106.0	COG1937@1|root,COG1937@2|Bacteria,2G7H9@200795|Chloroflexi	200795|Chloroflexi	S	Metal-sensitive transcriptional repressor	-	-	-	ko:K21600	-	-	-	-	ko00000,ko03000	-	-	-	Trns_repr_metal
k59_1328723_1	1260251.SPISAL_00375	4.89e-47	173.0	COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,1RN8K@1236|Gammaproteobacteria,1WWM2@135613|Chromatiales	135613|Chromatiales	C	Dehydrogenase E1 component	sucA	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
k59_1547053_1	643562.Daes_2709	8.54e-54	193.0	COG0058@1|root,COG0438@1|root,COG0058@2|Bacteria,COG0438@2|Bacteria,1MW4J@1224|Proteobacteria,42MEQ@68525|delta/epsilon subdivisions,2WIPF@28221|Deltaproteobacteria,2M7US@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	Glycosyl transferase, family 35	glgP	-	2.4.1.1,2.4.1.11	ko:K00688,ko:K16153	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R00292,R02111	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT3,GT35	-	DUF3417,Glycogen_syn,Phosphorylase
k59_1770231_1	63737.Npun_R0619	1.73e-24	100.0	COG1028@1|root,COG1028@2|Bacteria,1G7G6@1117|Cyanobacteria,1HQIB@1161|Nostocales	1117|Cyanobacteria	C	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_1770231_2	706587.Desti_4721	2.92e-24	93.6	2DZFA@1|root,32V98@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1658868_1	1123013.AUIC01000003_gene658	7.18e-13	73.6	COG1316@1|root,COG1316@2|Bacteria,2GM55@201174|Actinobacteria,4FKR4@85023|Microbacteriaceae	201174|Actinobacteria	K	Cell envelope-related transcriptional attenuator domain	-	-	-	-	-	-	-	-	-	-	-	-	LytR_cpsA_psr
k59_881819_2	5911.EAR94018	7.33e-05	50.1	2CYMK@1|root,2S566@2759|Eukaryota	2759|Eukaryota	S	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_Tnp_Tc3_2
k59_1161923_2	713586.KB900536_gene2996	2.25e-17	75.5	COG0776@1|root,COG0776@2|Bacteria,1MZ5B@1224|Proteobacteria,1S8VH@1236|Gammaproteobacteria,1WYVU@135613|Chromatiales	135613|Chromatiales	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	-	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
k59_327694_1	1380391.JIAS01000017_gene456	4.39e-64	204.0	COG0300@1|root,COG0300@2|Bacteria,1PNDU@1224|Proteobacteria,2U8P8@28211|Alphaproteobacteria,2JP98@204441|Rhodospirillales	204441|Rhodospirillales	S	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_881836_1	313596.RB2501_02320	1.23e-118	358.0	COG0465@1|root,COG0465@2|Bacteria,4NF0E@976|Bacteroidetes,1HXSC@117743|Flavobacteriia	976|Bacteroidetes	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_1658881_1	243365.CV_0600	4.6e-55	189.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,2VHGU@28216|Betaproteobacteria,2KQHZ@206351|Neisseriales	206351|Neisseriales	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	coxA	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_381813_1	568706.BN118_3528	1.55e-76	242.0	COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,2VH54@28216|Betaproteobacteria,3T1X3@506|Alcaligenaceae	28216|Betaproteobacteria	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2,NTP_transf_3
k59_1274165_1	234267.Acid_2795	6.84e-28	105.0	2CHCP@1|root,32S5R@2|Bacteria	2|Bacteria	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
k59_1274165_2	1185876.BN8_01713	5.07e-09	56.6	COG0454@1|root,COG0662@1|root,COG0456@2|Bacteria,COG0662@2|Bacteria,4NTZN@976|Bacteroidetes,47RG8@768503|Cytophagia	976|Bacteroidetes	G	ARD/ARD' family	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_268212_1	926569.ANT_03360	8.45e-14	70.1	COG0077@1|root,COG0077@2|Bacteria,2G6AP@200795|Chloroflexi	200795|Chloroflexi	E	amino acid-binding ACT domain protein	pheA	-	4.2.1.51	ko:K04518	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024	R00691,R01373	RC00360	ko00000,ko00001,ko00002,ko01000	-	-	-	PDT
k59_268212_2	431943.CKL_0514	5.45e-05	48.9	COG0443@1|root,COG0443@2|Bacteria,1TP1J@1239|Firmicutes	1239|Firmicutes	O	Heat shock 70 kDa protein	-	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
k59_212051_1	861299.J421_1666	1.83e-15	81.3	COG0515@1|root,COG0515@2|Bacteria,1ZUM6@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
k59_1658898_1	686340.Metal_0415	3.67e-33	122.0	28NKC@1|root,2ZBM7@2|Bacteria,1MWMY@1224|Proteobacteria,1S4WY@1236|Gammaproteobacteria,1XGAR@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1383355_1	37659.JNLN01000001_gene1111	3.94e-16	78.2	COG0446@1|root,COG0446@2|Bacteria,1TPWW@1239|Firmicutes,2484C@186801|Clostridia,36EYM@31979|Clostridiaceae	186801|Clostridia	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim,Rhodanese
k59_1494869_1	861299.J421_2788	5.37e-09	54.3	COG0096@1|root,COG0096@2|Bacteria,1ZTMD@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	-	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
k59_1494869_2	59538.XP_005973177.1	6.24e-30	113.0	COG0094@1|root,KOG0398@2759|Eukaryota,38D2V@33154|Opisthokonta,3BZST@33208|Metazoa	33154|Opisthokonta	J	Ribosomal protein L5	mrpl7	GO:0000027,GO:0000313,GO:0000315,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005761,GO:0005762,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0031974,GO:0032543,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070013,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0098798,GO:0140053,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
k59_994324_1	179408.Osc7112_2732	1.7e-106	324.0	COG1249@1|root,COG1249@2|Bacteria,1G198@1117|Cyanobacteria,1H7PH@1150|Oscillatoriales	1117|Cyanobacteria	C	Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase	merA	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim,SNARE_assoc
k59_381831_1	1206725.BAFU01000007_gene4200	9.56e-32	126.0	COG1012@1|root,COG1012@2|Bacteria,2GJ95@201174|Actinobacteria,4FUME@85025|Nocardiaceae	201174|Actinobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.99.10	ko:K22445	-	-	-	-	ko00000,ko01000	-	-	-	Aldedh
k59_1494872_1	1504823.CCMM01000008_gene884	5.79e-28	112.0	COG1196@1|root,COG1196@2|Bacteria,2NNYZ@2323|unclassified Bacteria	2|Bacteria	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
k59_46744_1	492774.JQMB01000002_gene1177	5.76e-119	350.0	COG0654@1|root,COG0654@2|Bacteria,1MWWT@1224|Proteobacteria,2TRZP@28211|Alphaproteobacteria,4BDDR@82115|Rhizobiaceae	28211|Alphaproteobacteria	CH	FAD binding domain	-	-	1.14.13.1,1.14.13.114	ko:K00480,ko:K14974	ko00621,ko00624,ko00626,ko00760,ko01100,ko01120,ko01220,map00621,map00624,map00626,map00760,map01100,map01120,map01220	M00622	R00818,R05632,R06915,R06936,R06939,R08764	RC00115,RC00389	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3,NAD_binding_8
k59_952689_1	867903.ThesuDRAFT_02315	3.38e-69	222.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,1TPE2@1239|Firmicutes,25CRT@186801|Clostridia	186801|Clostridia	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,Rhodanese
k59_118629_1	1499680.CCFE01000030_gene3602	1.04e-32	128.0	COG1940@1|root,COG1940@2|Bacteria,1TQCE@1239|Firmicutes,4HDE3@91061|Bacilli,1ZC4Y@1386|Bacillus	91061|Bacilli	GK	ROK family	xylR	-	-	-	-	-	-	-	-	-	-	-	HTH_24,MarR_2,ROK
k59_1397562_2	243164.DET0083	0.000113	45.1	COG2963@1|root,COG2963@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	ko:K07483,ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,HTH_Tnp_1,rve_3
k59_396821_2	671143.DAMO_0610	3.72e-09	55.5	COG0494@1|root,COG0494@2|Bacteria,2NPTC@2323|unclassified Bacteria	2|Bacteria	L	NUDIX domain	nudF	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
k59_508083_1	880073.Calab_0924	1.25e-09	65.1	COG1629@1|root,COG4771@2|Bacteria,2NP6Z@2323|unclassified Bacteria	2|Bacteria	P	COGs COG1629 Outer membrane receptor protein mostly Fe transport	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec
k59_786109_1	189753.AXAS01000100_gene6801	7.86e-35	136.0	COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TTJ0@28211|Alphaproteobacteria,3JS5D@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,PAS_7,dCache_1
k59_1397590_1	379066.GAU_1314	5.69e-72	243.0	COG3696@1|root,COG3696@2|Bacteria,1ZUB0@142182|Gemmatimonadetes	2|Bacteria	P	AcrB/AcrD/AcrF family	cusA	-	-	ko:K07787,ko:K15726	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.2,2.A.6.1.4	-	iAF987.Gmet_1547	ACR_tran
k59_1619728_1	706587.Desti_3797	5.87e-31	124.0	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,42N83@68525|delta/epsilon subdivisions,2WJFF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
k59_285817_1	91464.S7335_4911	3.52e-06	57.0	COG0747@1|root,COG0747@2|Bacteria,1G0S3@1117|Cyanobacteria,1H02V@1129|Synechococcus	1117|Cyanobacteria	E	Extracellular solute-binding protein	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_730758_1	1380346.JNIH01000016_gene533	8.83e-67	217.0	COG4608@1|root,COG4608@2|Bacteria,2H4BW@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_1008603_1	344747.PM8797T_00327	7.8e-44	166.0	COG1228@1|root,COG1228@2|Bacteria,2IYFS@203682|Planctomycetes	203682|Planctomycetes	Q	COG1228 Imidazolonepropionase and related	-	-	3.5.1.25	ko:K01443	ko00520,ko01130,map00520,map01130	-	R02059	RC00166,RC00300	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
k59_63324_1	1125863.JAFN01000001_gene1650	4.14e-135	398.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WJ88@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	two component, sigma54 specific, transcriptional regulator, Fis family	ntrX	-	-	ko:K13599	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_563457_1	1097668.BYI23_B005320	5.4e-59	187.0	2CD0I@1|root,32RWS@2|Bacteria,1N0MC@1224|Proteobacteria,2WFYG@28216|Betaproteobacteria,1KI7K@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Domain of unknown function (DUF4399)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4399
k59_508112_1	926569.ANT_09470	5.61e-73	228.0	COG1624@1|root,COG1624@2|Bacteria,2G6J7@200795|Chloroflexi	200795|Chloroflexi	S	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria	dacA	-	2.7.7.85	ko:K18672	-	-	-	-	ko00000,ko01000	-	-	-	DisA_N
k59_1175188_2	391165.GbCGDNIH1_0317	5.16e-13	70.5	COG0260@1|root,COG0260@2|Bacteria,1MUIN@1224|Proteobacteria,2TSI6@28211|Alphaproteobacteria,2JUXA@204441|Rhodospirillales	204441|Rhodospirillales	E	Cytosol aminopeptidase family, catalytic domain	-	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17
k59_619146_1	1229172.JQFA01000002_gene3348	7.27e-05	48.5	COG4243@1|root,COG4243@2|Bacteria,1FZWT@1117|Cyanobacteria,1H90D@1150|Oscillatoriales	1117|Cyanobacteria	CO	Vitamin k epoxide reductase	-	-	-	-	-	-	-	-	-	-	-	-	VKOR
k59_63343_1	1122132.AQYH01000019_gene385	1.13e-27	101.0	2E4B6@1|root,32Z6W@2|Bacteria,1N7QS@1224|Proteobacteria,2UFNH@28211|Alphaproteobacteria,4BG0V@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3126)	MA20_32250	-	-	-	-	-	-	-	-	-	-	-	DUF3126
k59_1120035_1	1479235.KK366039_gene2914	6.96e-08	57.0	COG3167@1|root,COG3167@2|Bacteria,1RBGW@1224|Proteobacteria,1S3XQ@1236|Gammaproteobacteria,1XJVN@135619|Oceanospirillales	135619|Oceanospirillales	NU	Pilus assembly protein PilO	pilO	-	-	ko:K02664	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilO
k59_730796_1	76869.PputGB1_5271	3.49e-48	164.0	COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,1RPRD@1236|Gammaproteobacteria,1YV7U@136845|Pseudomonas putida group	1236|Gammaproteobacteria	C	alcohol dehydrogenase	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_730796_2	543728.Vapar_1558	1.36e-12	68.2	COG0665@1|root,COG0665@2|Bacteria,1MY0G@1224|Proteobacteria,2VM19@28216|Betaproteobacteria,4ABT0@80864|Comamonadaceae	28216|Betaproteobacteria	E	FAD dependent oxidoreductase	-	-	1.4.99.6	ko:K19746	ko00472,ko01100,map00472,map01100	-	R11018	RC00006	ko00000,ko00001,ko01000	-	-	-	DAO
k59_619155_2	402881.Plav_2951	4.39e-29	107.0	COG0346@1|root,COG0346@2|Bacteria,1RCYX@1224|Proteobacteria,2U7A8@28211|Alphaproteobacteria,1JNV5@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	gloA	GO:0003674,GO:0003824,GO:0004462,GO:0006518,GO:0006575,GO:0006749,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016846,GO:0034641,GO:0043603,GO:0044237,GO:0051186,GO:0071704,GO:1901564	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
k59_8000_2	1131269.AQVV01000028_gene45	6.84e-16	77.4	COG0535@1|root,COG0535@2|Bacteria	2|Bacteria	I	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,PCP_red,Radical_SAM,SPASM
k59_730798_1	861299.J421_6292	2.4e-55	176.0	COG0347@1|root,COG0347@2|Bacteria,1ZTTV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Nitrogen regulatory protein P-II	-	-	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
k59_730798_2	861299.J421_6291	1.01e-06	49.7	COG0004@1|root,COG0004@2|Bacteria,1ZT74@142182|Gemmatimonadetes	142182|Gemmatimonadetes	U	Ammonium Transporter Family	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_1731127_1	263358.VAB18032_12160	3.5e-26	114.0	COG1201@1|root,COG1201@2|Bacteria,2GJG3@201174|Actinobacteria,4D8IH@85008|Micromonosporales	201174|Actinobacteria	L	DEAD H associated domain protein	lhr	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,HTH_42,Helicase_C
k59_1731128_1	194867.ALBQ01000014_gene401	1.12e-15	76.6	COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,2TQNE@28211|Alphaproteobacteria,2K0JQ@204457|Sphingomonadales	204457|Sphingomonadales	H	Belongs to the prokaryotic GSH synthase family	gshB	-	6.3.2.3	ko:K01920	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00497,R10994	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	GSH-S_ATP,GSH-S_N
k59_1619793_1	378806.STAUR_8070	9.16e-19	90.9	COG0642@1|root,COG2205@2|Bacteria,1QX6V@1224|Proteobacteria,43BZK@68525|delta/epsilon subdivisions,2X7AC@28221|Deltaproteobacteria,2YYIJ@29|Myxococcales	28221|Deltaproteobacteria	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_4
k59_174542_1	1305737.JAFX01000001_gene1824	1.4e-45	170.0	COG1629@1|root,COG4771@2|Bacteria,4NDU8@976|Bacteroidetes,47M35@768503|Cytophagia	976|Bacteroidetes	P	PFAM TonB-dependent Receptor Plug	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
k59_730829_1	376733.IT41_19990	2.88e-101	296.0	COG3335@1|root,COG3335@2|Bacteria,1P76X@1224|Proteobacteria,2U16U@28211|Alphaproteobacteria,2PXYA@265|Paracoccus	28211|Alphaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
k59_952809_1	697303.Thewi_0963	4.92e-17	82.8	COG0741@1|root,COG0741@2|Bacteria,1V6K4@1239|Firmicutes,24JB5@186801|Clostridia,42GIF@68295|Thermoanaerobacterales	186801|Clostridia	M	PFAM Lytic transglycosylase catalytic	-	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT
k59_1675657_1	1197130.BAFM01000012_gene2204	6.99e-17	85.1	arCOG02903@1|root,arCOG03612@1|root,arCOG02903@2157|Archaea,arCOG03612@2157|Archaea	2157|Archaea	P	PhoD-like phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	ASH,Big_1,DUF1573,PKD,VWA
k59_730848_1	1122951.ATUE01000005_gene1595	1.66e-07	53.5	2E445@1|root,32Z0E@2|Bacteria,1N7FY@1224|Proteobacteria,1SDJE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_843307_1	234267.Acid_7843	9.24e-09	57.8	COG1793@1|root,COG1793@2|Bacteria,3Y2VV@57723|Acidobacteria	57723|Acidobacteria	L	DNA polymerase LigD, ligase domain	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
k59_843307_2	357808.RoseRS_0218	2.59e-18	83.2	COG0346@1|root,COG0346@2|Bacteria,2G8K0@200795|Chloroflexi,37776@32061|Chloroflexia	32061|Chloroflexia	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase_3
k59_1343846_1	290397.Adeh_3905	2.33e-101	316.0	COG2225@1|root,COG2225@2|Bacteria,1MVEV@1224|Proteobacteria,42P3R@68525|delta/epsilon subdivisions,2X349@28221|Deltaproteobacteria,2YU6W@29|Myxococcales	28221|Deltaproteobacteria	H	Malate synthase	-	-	2.3.3.9	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472	RC00004,RC00308,RC02747	ko00000,ko00001,ko00002,ko01000	-	-	-	Malate_synthase
k59_565400_1	411902.CLOBOL_04837	3.48e-16	82.4	COG0791@1|root,COG3772@1|root,COG0791@2|Bacteria,COG3772@2|Bacteria,1VG3D@1239|Firmicutes,25FTG@186801|Clostridia,223QR@1506553|Lachnoclostridium	186801|Clostridia	M	Phage lysozyme	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_621002_1	1211114.ALIP01000006_gene940	8.07e-20	94.0	COG0823@1|root,COG3710@1|root,COG0823@2|Bacteria,COG3710@2|Bacteria,1PYUK@1224|Proteobacteria,1S0VV@1236|Gammaproteobacteria,1X5W9@135614|Xanthomonadales	135614|Xanthomonadales	KU	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Trans_reg_C
k59_398868_1	926550.CLDAP_10730	8.45e-16	82.0	COG1572@1|root,COG1572@2|Bacteria,2G7MU@200795|Chloroflexi	200795|Chloroflexi	S	Peptidase family C25	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C25
k59_1455540_1	926550.CLDAP_30940	1e-198	563.0	COG0076@1|root,COG0076@2|Bacteria,2G7N6@200795|Chloroflexi	200795|Chloroflexi	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	4.1.1.105,4.1.1.28,4.1.2.27	ko:K01593,ko:K01634	ko00350,ko00360,ko00380,ko00600,ko00901,ko00950,ko00965,ko01100,ko01110,ko04071,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00600,map00901,map00950,map00965,map01100,map01110,map04071,map04726,map04728,map05030,map05031,map05034	M00037,M00042,M00100	R00685,R00699,R00736,R02080,R02464,R02701,R04909,R06516	RC00264,RC00299,RC00721,RC01266	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyridoxal_deC
k59_1621593_1	869210.Marky_1642	1.8e-64	209.0	COG3033@1|root,COG3033@2|Bacteria,1WM62@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	PFAM aromatic amino acid beta-eliminating lyase threonine aldolase	tnaA	-	4.1.99.1	ko:K01667	ko00380,map00380	-	R00673	RC00209,RC00355	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
k59_732814_1	1121899.Q764_09630	8.37e-69	229.0	COG0008@1|root,COG0008@2|Bacteria,4NFCC@976|Bacteroidetes,1HXAH@117743|Flavobacteriia,2NTPZ@237|Flavobacterium	976|Bacteroidetes	J	Catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA	glnS	-	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
k59_120634_1	1286631.X805_31000	2.93e-14	78.2	COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,2VI92@28216|Betaproteobacteria,1KKD0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA	recB	-	3.1.11.5,3.6.4.12	ko:K03582,ko:K16898	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
k59_677159_1	377629.TERTU_1374	1.83e-37	139.0	COG0835@1|root,COG0835@2|Bacteria,1MYHY@1224|Proteobacteria,1S2TC@1236|Gammaproteobacteria,2PNJ4@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	NT	Two component signalling adaptor domain	VP2226	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
k59_1288357_1	1121924.ATWH01000024_gene1059	4.8e-26	109.0	COG0477@1|root,COG0477@2|Bacteria,2GTXI@201174|Actinobacteria,4FMTQ@85023|Microbacteriaceae	201174|Actinobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
k59_1677500_2	1379270.AUXF01000003_gene3608	4.53e-89	295.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,1ZSS1@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Tricorn protease homolog	-	-	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
k59_65252_2	756272.Plabr_3464	6.51e-35	135.0	COG1523@1|root,COG1523@2|Bacteria,2IXJM@203682|Planctomycetes	203682|Planctomycetes	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
k59_565439_1	1142394.PSMK_19040	1.81e-34	136.0	COG0366@1|root,COG0366@2|Bacteria	2|Bacteria	G	hydrolase activity, hydrolyzing O-glycosyl compounds	-	-	3.2.1.133,3.2.1.135,3.2.1.54	ko:K01208	ko00500,ko01100,map00500,map01100	-	R02112,R03122,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	AMPK1_CBM,Alpha-amylase,Malt_amylase_C
k59_1733062_1	395493.BegalDRAFT_2280	3.09e-74	233.0	COG0451@1|root,COG0451@2|Bacteria,1MU7J@1224|Proteobacteria,1RPTA@1236|Gammaproteobacteria,461Y0@72273|Thiotrichales	72273|Thiotrichales	M	Polysaccharide biosynthesis protein	-	-	5.1.3.7	ko:K02473	ko00520,ko01100,map00520,map01100	-	R00418	RC00289	ko00000,ko00001,ko01000	-	-	-	Epimerase
k59_1621621_1	861299.J421_2774	2.54e-42	146.0	COG0087@1|root,COG0087@2|Bacteria,1ZSW4@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
k59_1233959_1	742159.HMPREF0004_5182	1.54e-28	118.0	COG4772@1|root,COG4772@2|Bacteria,1MUIH@1224|Proteobacteria,2VKC9@28216|Betaproteobacteria,3T1KS@506|Alcaligenaceae	28216|Betaproteobacteria	P	TonB-dependent receptor	yncD	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k59_1566453_1	1079460.ATTQ01000008_gene1214	2e-38	140.0	COG0392@1|root,COG0392@2|Bacteria,1MXH9@1224|Proteobacteria,2U1DX@28211|Alphaproteobacteria,4B8UY@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
k59_1566453_2	331869.BAL199_28370	1.33e-42	155.0	COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,2TU9Q@28211|Alphaproteobacteria,4BRFE@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	I	Phospholipase D. Active site motifs.	-	-	-	ko:K06132	ko00564,ko01100,map00564,map01100	-	R11062	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
k59_65264_1	1265502.KB905930_gene1414	1.7e-67	212.0	COG1285@1|root,COG1285@2|Bacteria,1MURJ@1224|Proteobacteria,2WA1J@28216|Betaproteobacteria,4AFHN@80864|Comamonadaceae	28216|Betaproteobacteria	S	MgtC family	-	-	-	ko:K07507	-	-	-	-	ko00000,ko02000	9.B.20	-	-	MgtC
k59_287866_2	443152.MDG893_15437	1.07e-56	186.0	COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,1RMNY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_120658_1	935261.JAGL01000002_gene1446	1.16e-74	238.0	COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria,43IFB@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	Q	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_120658_2	1411123.JQNH01000001_gene2709	1.13e-09	58.5	COG4665@1|root,COG4665@2|Bacteria,1RHBW@1224|Proteobacteria,2U4QB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	TRAP-type mannitol chloroaromatic compound transport system, small permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
k59_732847_1	1246995.AFR_16250	2.39e-13	75.1	COG2203@1|root,COG4585@1|root,COG2203@2|Bacteria,COG4585@2|Bacteria,2I8X1@201174|Actinobacteria,4DH0K@85008|Micromonosporales	201174|Actinobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GerE,HisKA_3
k59_510045_1	1449346.JQMO01000003_gene4188	2.68e-14	73.6	COG0444@1|root,COG0444@2|Bacteria,2GIXV@201174|Actinobacteria,2M20N@2063|Kitasatospora	201174|Actinobacteria	P	Oligopeptide/dipeptide transporter, C-terminal region	dppD	-	-	ko:K02031,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
k59_1510852_1	997346.HMPREF9374_3800	4.14e-67	223.0	COG3044@1|root,COG3044@2|Bacteria,1TPJ9@1239|Firmicutes,4HA35@91061|Bacilli,27AYF@186824|Thermoactinomycetaceae	91061|Bacilli	S	Predicted ATPase of the ABC class	-	-	-	-	-	-	-	-	-	-	-	-	ABC_ATPase
k59_1566474_1	518766.Rmar_1649	6e-92	287.0	COG1115@1|root,COG1115@2|Bacteria,4NDX7@976|Bacteroidetes,1FIXE@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	E	Sodium:alanine symporter family	-	-	-	ko:K03310	-	-	-	-	ko00000	2.A.25	-	-	Na_Ala_symp
k59_1122165_1	311402.Avi_5293	2.55e-13	70.5	COG4608@1|root,COG4608@2|Bacteria,1NQSU@1224|Proteobacteria,2UQPN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,oligo_HPY
k59_176440_2	338963.Pcar_2715	3.02e-27	108.0	COG0668@1|root,COG0668@2|Bacteria,1QATN@1224|Proteobacteria,42RFA@68525|delta/epsilon subdivisions,2WNFU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
k59_398942_1	861299.J421_0211	4.63e-30	123.0	COG0577@1|root,COG0577@2|Bacteria	861299.J421_0211|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1413376_1	1278073.MYSTI_00066	2.42e-70	238.0	COG0823@1|root,COG1228@1|root,COG0823@2|Bacteria,COG1228@2|Bacteria,1MX3A@1224|Proteobacteria,438QJ@68525|delta/epsilon subdivisions,2X3XW@28221|Deltaproteobacteria,2YXIE@29|Myxococcales	28221|Deltaproteobacteria	QU	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,PD40
k59_914454_1	765913.ThidrDRAFT_0624	1.16e-60	191.0	COG2110@1|root,COG2110@2|Bacteria,1RCWP@1224|Proteobacteria,1S3WJ@1236|Gammaproteobacteria,1WYF4@135613|Chromatiales	135613|Chromatiales	S	PFAM Appr-1-p processing domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Macro
k59_1524551_1	1122138.AQUZ01000002_gene2070	1.04e-74	239.0	COG0477@1|root,COG0477@2|Bacteria,2ID82@201174|Actinobacteria,4DPS5@85009|Propionibacteriales	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1191151_1	243231.GSU2599	2.87e-88	271.0	COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,42NNQ@68525|delta/epsilon subdivisions,2WM2H@28221|Deltaproteobacteria,43TYM@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1191156_1	483219.LILAB_13130	5.6e-19	90.1	COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,42MSJ@68525|delta/epsilon subdivisions,2WKHJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM Extracellular ligand-binding receptor	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_1079693_1	1048339.KB913029_gene4283	5.1e-49	173.0	2DNJB@1|root,32XT8@2|Bacteria,2H1A6@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_189993_1	105425.BBPL01000091_gene8127	4.58e-117	344.0	COG0667@1|root,COG0667@2|Bacteria,2GJ4R@201174|Actinobacteria,2NEZK@228398|Streptacidiphilus	201174|Actinobacteria	C	Aldo/keto reductase family	-	-	1.1.1.65	ko:K05275	ko00750,ko01100,ko01120,map00750,map01100,map01120	-	R01708	RC00116	ko00000,ko00001,ko01000	-	-	-	Aldo_ket_red
k59_245631_1	1121875.KB907547_gene2926	2.58e-27	103.0	COG1917@1|root,COG1917@2|Bacteria	2|Bacteria	L	Cupin 2, conserved barrel domain protein	-	-	5.3.1.15	ko:K09988	ko00040,map00040	-	R01898	RC00516	ko00000,ko00001,ko01000	-	-	-	Cupin_2,Cupin_7
k59_245631_2	204669.Acid345_1382	1.8e-09	57.0	2BM3X@1|root,33KY1@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1524571_2	223184.AS25_10680	9.95e-05	44.3	2E4NY@1|root,32ZHR@2|Bacteria,2GQPW@201174|Actinobacteria,1W9YX@1268|Micrococcaceae	201174|Actinobacteria	D	Involved in cell division	crgA	-	-	-	-	-	-	-	-	-	-	-	CrgA
k59_134177_1	864069.MicloDRAFT_00020450	8.24e-84	263.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,2TQXC@28211|Alphaproteobacteria,1JRME@119045|Methylobacteriaceae	28211|Alphaproteobacteria	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.1.1.205,1.7.1.7	ko:K00088,ko:K00364	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R01134,R08240	RC00143,RC00457,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH,NMO
k59_634118_2	1122917.KB899672_gene798	1.08e-56	186.0	COG0667@1|root,COG0667@2|Bacteria,1V300@1239|Firmicutes,4HERM@91061|Bacilli,26TBI@186822|Paenibacillaceae	91061|Bacilli	C	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_1248441_1	671143.DAMO_2476	2.13e-42	147.0	COG0637@1|root,COG0637@2|Bacteria	2|Bacteria	S	phosphonoacetaldehyde hydrolase activity	-	-	2.6.1.9,3.1.3.10,3.8.1.2	ko:K00817,ko:K01560,ko:K07025,ko:K20866	ko00010,ko00340,ko00350,ko00360,ko00361,ko00400,ko00401,ko00625,ko00960,ko01100,ko01110,ko01120,ko01130,ko01230,map00010,map00340,map00350,map00360,map00361,map00400,map00401,map00625,map00960,map01100,map01110,map01120,map01130,map01230	M00026	R00694,R00734,R00947,R03243,R05287	RC00006,RC00078,RC00697,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	HAD_2,Hydrolase
k59_23723_1	1370120.AUWR01000018_gene1319	1.82e-54	182.0	COG0075@1|root,COG0075@2|Bacteria,2H16A@201174|Actinobacteria,23CSV@1762|Mycobacteriaceae	201174|Actinobacteria	E	Aminotransferase class-V	agxT	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
k59_746498_1	1207063.P24_02301	3.02e-159	466.0	COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,2TRH3@28211|Alphaproteobacteria,2JPZ2@204441|Rhodospirillales	204441|Rhodospirillales	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
k59_1580295_1	350054.Mflv_1025	1.83e-19	88.2	COG1454@1|root,COG1454@2|Bacteria,2I2FD@201174|Actinobacteria,2369R@1762|Mycobacteriaceae	201174|Actinobacteria	C	alcohol dehydrogenase	adhfe	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
k59_1580295_2	159450.NH14_14250	3.18e-09	57.8	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VHGR@28216|Betaproteobacteria,1K02G@119060|Burkholderiaceae	28216|Betaproteobacteria	C	belongs to the aldehyde dehydrogenase family	gabD	-	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_190035_1	1206101.AZXC01000009_gene515	2.41e-63	211.0	COG0477@1|root,COG0477@2|Bacteria,2GITS@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1469344_1	1123037.AUDE01000001_gene1918	4.39e-96	292.0	COG0025@1|root,COG0025@2|Bacteria,4NF54@976|Bacteroidetes,1HYT6@117743|Flavobacteriia	976|Bacteroidetes	P	sodium proton antiporter	-	-	-	ko:K03316	-	-	-	-	ko00000	2.A.36	-	-	Na_H_Exchanger
k59_691238_1	1123239.KB898623_gene1640	4.28e-12	73.9	COG4632@1|root,COG4632@2|Bacteria,1TQBV@1239|Firmicutes,4H9WI@91061|Bacilli	91061|Bacilli	G	copper amine oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Cu_amine_oxidN1,NAGPA,SLH
k59_1746379_1	264732.Moth_1900	1.05e-80	252.0	COG1131@1|root,COG1131@2|Bacteria,1TQKM@1239|Firmicutes,25B35@186801|Clostridia,42FFN@68295|Thermoanaerobacterales	186801|Clostridia	V	pfam abc	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_802105_1	675635.Psed_4866	1.92e-39	147.0	COG0586@1|root,COG0671@1|root,COG0586@2|Bacteria,COG0671@2|Bacteria,2GKKC@201174|Actinobacteria,4E2BV@85010|Pseudonocardiales	201174|Actinobacteria	V	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
k59_1191227_2	397945.Aave_2081	1.34e-45	162.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VHGR@28216|Betaproteobacteria,4A9Q8@80864|Comamonadaceae	28216|Betaproteobacteria	C	belongs to the aldehyde dehydrogenase family	-	-	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_524057_1	484022.Fphi_0811	1.56e-09	61.2	COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,1RQ7F@1236|Gammaproteobacteria,4627Q@72273|Thiotrichales	72273|Thiotrichales	O	Redoxin	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
k59_1580347_1	671143.DAMO_1500	2.85e-117	357.0	COG3808@1|root,COG3808@2|Bacteria,2NNK9@2323|unclassified Bacteria	2|Bacteria	C	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
k59_802133_1	1280948.HY36_11210	1.02e-12	67.8	COG0524@1|root,COG0524@2|Bacteria,1MUUC@1224|Proteobacteria,2TS9D@28211|Alphaproteobacteria,43WJU@69657|Hyphomonadaceae	28211|Alphaproteobacteria	G	COG0524 Sugar kinases, ribokinase family	pfkB	-	2.7.1.20,2.7.1.4	ko:K00847,ko:K00856	ko00051,ko00230,ko00500,ko00520,ko01100,map00051,map00230,map00500,map00520,map01100	-	R00185,R00760,R00867,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
k59_802133_2	570967.JMLV01000002_gene1869	3.46e-74	239.0	COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,2TR63@28211|Alphaproteobacteria,2JQ9U@204441|Rhodospirillales	204441|Rhodospirillales	T	GTP-binding protein TypA	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
k59_1302557_1	930946.AEOP01000050_gene53	9.03e-05	47.0	COG0781@1|root,COG0781@2|Bacteria,1VA9B@1239|Firmicutes,4HKMU@91061|Bacilli,4AXRM@81850|Leuconostocaceae	91061|Bacilli	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
k59_1302557_2	199310.c0525	2.63e-05	45.4	COG0054@1|root,COG0054@2|Bacteria,1RD9J@1224|Proteobacteria,1S3WD@1236|Gammaproteobacteria,3XMBY@561|Escherichia	1236|Gammaproteobacteria	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	iSFV_1184.SFV_0380	DMRL_synthase
k59_190105_1	997350.HMPREF9129_0690	3.07e-47	166.0	COG0183@1|root,COG0183@2|Bacteria,1TP07@1239|Firmicutes,2482I@186801|Clostridia,22GK8@1570339|Peptoniphilaceae	186801|Clostridia	I	Belongs to the thiolase family	phbA	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_1136109_1	323098.Nwi_0283	2.46e-64	222.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,2TQTG@28211|Alphaproteobacteria,3JUU3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	B12 binding domain	metH	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_356754_1	582515.KR51_00005380	1.31e-35	135.0	COG0530@1|root,COG0530@2|Bacteria,1G1Y9@1117|Cyanobacteria	1117|Cyanobacteria	P	Sodium calcium exchanger	ecm27	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
k59_79031_1	1267533.KB906740_gene380	2.71e-47	166.0	COG0577@1|root,COG0577@2|Bacteria,3Y2MV@57723|Acidobacteria,2JI8C@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_1191270_1	225937.HP15_1131	1.02e-135	390.0	COG0189@1|root,COG0189@2|Bacteria,1MVDU@1224|Proteobacteria,1RR7D@1236|Gammaproteobacteria,464QG@72275|Alteromonadaceae	1236|Gammaproteobacteria	HJ	COG0189 Glutathione synthase Ribosomal protein S6 modification enzyme (glutaminyl transferase)	PA1766	-	-	-	-	-	-	-	-	-	-	-	ATPgrasp_ST
k59_916414_1	981384.AEYW01000013_gene799	9.64e-24	100.0	29681@1|root,2ZTI1@2|Bacteria,1RA8W@1224|Proteobacteria,2U6CU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Peptidase M50B-like	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50B
k59_580567_2	1380394.JADL01000001_gene2663	1.01e-17	85.1	COG1028@1|root,COG1028@2|Bacteria,1MU2T@1224|Proteobacteria,2TSDG@28211|Alphaproteobacteria,2JQMS@204441|Rhodospirillales	204441|Rhodospirillales	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_748210_1	1462527.CCDM010000001_gene2670	5.71e-32	125.0	COG0028@1|root,COG0028@2|Bacteria,1TQE8@1239|Firmicutes,4H9VR@91061|Bacilli,23JE7@182709|Oceanobacillus	91061|Bacilli	EH	Thiamine pyrophosphate enzyme, central domain	-	-	-	-	-	-	-	-	-	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_748210_2	314292.VAS14_06343	1.47e-14	75.1	COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,1RP6Z@1236|Gammaproteobacteria,1XUBQ@135623|Vibrionales	135623|Vibrionales	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
k59_471405_1	926550.CLDAP_17640	8.33e-05	43.9	COG2170@1|root,COG2170@2|Bacteria,2G5NR@200795|Chloroflexi	200795|Chloroflexi	H	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity	-	-	-	ko:K06048	-	-	-	-	ko00000,ko01000	-	-	-	GCS2
k59_471405_2	1089548.KI783301_gene1751	1.75e-43	151.0	COG0321@1|root,COG0321@2|Bacteria,1V44P@1239|Firmicutes,4HH4H@91061|Bacilli	91061|Bacilli	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	-	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
k59_1471323_1	1358423.N180_18845	1.23e-13	70.9	COG1595@1|root,COG1595@2|Bacteria,4NM40@976|Bacteroidetes,1IRKZ@117747|Sphingobacteriia	976|Bacteroidetes	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2
k59_1138019_1	991905.SL003B_4075	1.44e-52	181.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria	1224|Proteobacteria	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_38,HTH_7,rve
k59_471406_1	649831.L083_7062	5.01e-37	137.0	COG0224@1|root,COG0224@2|Bacteria,2GJ7Q@201174|Actinobacteria,4D8FX@85008|Micromonosporales	201174|Actinobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
k59_1081632_1	247490.KSU1_D0577	2.06e-80	265.0	COG0243@1|root,COG0243@2|Bacteria,2J2QN@203682|Planctomycetes	203682|Planctomycetes	C	Molybdopterin oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Molybdopterin
k59_971185_1	649831.L083_0270	2.93e-65	208.0	COG0714@1|root,COG0714@2|Bacteria,2GK07@201174|Actinobacteria,4DCFG@85008|Micromonosporales	201174|Actinobacteria	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
k59_1304384_1	215803.DB30_8760	8.32e-34	134.0	COG0457@1|root,COG0457@2|Bacteria,1Q3YA@1224|Proteobacteria,437VH@68525|delta/epsilon subdivisions,2X354@28221|Deltaproteobacteria,2YUAY@29|Myxococcales	28221|Deltaproteobacteria	S	Peptidase family M49	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M49
k59_1582160_1	225937.HP15_775	1.82e-06	51.2	COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,1RN64@1236|Gammaproteobacteria,465S4@72275|Alteromonadaceae	1236|Gammaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	rpoE	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0006950,GO:0006970,GO:0008150,GO:0009266,GO:0009628,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_1359920_1	1122917.KB899679_gene467	5.12e-47	171.0	COG1197@1|root,COG1197@2|Bacteria,1TPF1@1239|Firmicutes,4H9NB@91061|Bacilli,26QY4@186822|Paenibacillaceae	91061|Bacilli	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_580617_1	1120956.JHZK01000001_gene3321	2.13e-87	273.0	COG0519@1|root,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,2TRN0@28211|Alphaproteobacteria,1JN5R@119043|Rhodobiaceae	28211|Alphaproteobacteria	F	GMP synthase C terminal domain	guaA	GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
k59_693170_1	1187851.A33M_2275	9.35e-39	144.0	COG0665@1|root,COG0665@2|Bacteria,1MVG3@1224|Proteobacteria,2V8C9@28211|Alphaproteobacteria,3FEF9@34008|Rhodovulum	28211|Alphaproteobacteria	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
k59_1193033_1	272942.RCAP_rcc00579	5.73e-66	215.0	COG1850@1|root,COG1850@2|Bacteria,1MWEB@1224|Proteobacteria,2TSJV@28211|Alphaproteobacteria,1FCHA@1060|Rhodobacter	28211|Alphaproteobacteria	G	RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site	cbbL	-	4.1.1.39	ko:K01601	ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200	M00165,M00166,M00532	R00024,R03140	RC00172,RC00859	ko00000,ko00001,ko00002,ko01000	-	-	-	RuBisCO_large,RuBisCO_large_N
k59_525842_2	926569.ANT_20430	1.78e-51	168.0	COG0193@1|root,COG0193@2|Bacteria,2G6SW@200795|Chloroflexi	200795|Chloroflexi	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
k59_303645_1	1304874.JAFY01000005_gene1220	5.27e-88	267.0	COG1692@1|root,COG1692@2|Bacteria,3T9TA@508458|Synergistetes	508458|Synergistetes	S	Metallophosphoesterase	-	-	-	ko:K09769	-	-	-	-	ko00000	-	-	-	YmdB
k59_303645_2	997296.PB1_00715	3.83e-143	421.0	COG1418@1|root,COG1418@2|Bacteria,1TP48@1239|Firmicutes,4HC9J@91061|Bacilli,1ZBGP@1386|Bacillus	91061|Bacilli	S	Endoribonuclease that initiates mRNA decay	rny	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
k59_1081681_1	768706.Desor_1495	2.76e-31	119.0	COG0791@1|root,COG0791@2|Bacteria,1V9ZW@1239|Firmicutes,25AZU@186801|Clostridia,264VT@186807|Peptococcaceae	186801|Clostridia	M	Cell wall-associated hydrolase (invasion-associated protein)	spr	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	NLPC_P60,SH3_3
k59_471474_1	1380394.JADL01000001_gene2992	4.35e-38	144.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TSB1@28211|Alphaproteobacteria,2JQBQ@204441|Rhodospirillales	204441|Rhodospirillales	EH	Belongs to the TPP enzyme family	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_858130_1	861299.J421_2526	7.77e-16	79.3	COG2802@1|root,COG2802@2|Bacteria,1ZUZ8@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	ATP-dependent protease La (LON) substrate-binding domain	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	LON_substr_bdg
k59_247481_1	485913.Krac_9623	5.95e-49	166.0	COG0258@1|root,COG0258@2|Bacteria	2|Bacteria	L	nuclease activity	polA	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_1081691_1	1027371.GOALK_001_00010	2.5e-76	239.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,2GJQI@201174|Actinobacteria,4GCQ9@85026|Gordoniaceae	201174|Actinobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_28,HTH_29,HTH_32
k59_1304431_1	742823.HMPREF9465_00039	7.09e-15	78.6	COG0657@1|root,COG0657@2|Bacteria,1R4AU@1224|Proteobacteria,2W8EW@28216|Betaproteobacteria,4PQ6Q@995019|Sutterellaceae	28216|Betaproteobacteria	I	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
k59_636091_1	1144310.PMI07_005299	7.25e-12	67.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TVI3@28211|Alphaproteobacteria,4BCQJ@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	-	-	-	-	-	-	-	-	-	TctA,TctB
k59_247488_2	342610.Patl_4063	8.88e-52	169.0	COG0225@1|root,COG0225@2|Bacteria,1MVUS@1224|Proteobacteria,1RNWU@1236|Gammaproteobacteria,2Q23T@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11,1.8.4.12	ko:K07304,ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR,SelR
k59_25617_1	1499967.BAYZ01000171_gene5534	2.19e-70	235.0	COG0589@1|root,COG1475@1|root,COG0589@2|Bacteria,COG1475@2|Bacteria,2NS1X@2323|unclassified Bacteria	2|Bacteria	K	DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	DUF4032,ParBc,Usp
k59_916525_1	240016.ABIZ01000001_gene3472	1.31e-54	179.0	COG2818@1|root,COG2818@2|Bacteria,46SS9@74201|Verrucomicrobia,2IUGS@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	Methyladenine glycosylase	-	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
k59_748289_1	1538295.JY96_13150	0.00028	44.3	COG4726@1|root,COG4726@2|Bacteria,1N9CE@1224|Proteobacteria,2VWPP@28216|Betaproteobacteria,1KMT5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	NU	Pilus assembly protein PilX	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_748289_2	1387312.BAUS01000004_gene1634	3.28e-05	50.8	COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,2VHY8@28216|Betaproteobacteria,2KKXA@206350|Nitrosomonadales	206350|Nitrosomonadales	NU	Neisseria PilC beta-propeller domain	-	-	-	ko:K02674	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Neisseria_PilC
k59_1526450_1	1121405.dsmv_1437	7.69e-11	62.8	COG0709@1|root,COG0709@2|Bacteria,1MWFG@1224|Proteobacteria,42MC3@68525|delta/epsilon subdivisions,2WK3M@28221|Deltaproteobacteria,2MN2H@213118|Desulfobacterales	28221|Deltaproteobacteria	E	AIR synthase related protein, N-terminal domain	selD	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C
k59_136172_1	1223521.BBJX01000004_gene2388	4.92e-44	153.0	COG0745@1|root,COG0745@2|Bacteria,1MWZ5@1224|Proteobacteria,2VIM1@28216|Betaproteobacteria,4ADS4@80864|Comamonadaceae	28216|Betaproteobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_916558_1	1414720.CBYM010000007_gene1110	1.33e-16	80.9	COG1480@1|root,COG1480@2|Bacteria,1TR1A@1239|Firmicutes,249W0@186801|Clostridia,36E2C@31979|Clostridiaceae	186801|Clostridia	S	SMART Metal-dependent phosphohydrolase, HD region	-	-	-	ko:K07037	-	-	-	-	ko00000	-	-	-	7TM-7TMR_HD,7TMR-HDED,HD
k59_1265317_1	1267535.KB906767_gene1396	1.73e-05	53.5	COG0457@1|root,COG0457@2|Bacteria,3Y9FF@57723|Acidobacteria,2JP7Q@204432|Acidobacteriia	204432|Acidobacteriia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_708184_1	861299.J421_1297	3.54e-91	278.0	COG0821@1|root,COG0821@2|Bacteria,1ZST3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
k59_1650081_1	1485544.JQKP01000011_gene736	1.68e-18	87.8	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2VI0U@28216|Betaproteobacteria,44V2C@713636|Nitrosomonadales	28216|Betaproteobacteria	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
k59_1650081_2	675815.VOA_001134	7.95e-05	45.4	2CJ6B@1|root,32S9B@2|Bacteria,1N2I4@1224|Proteobacteria,1S8Z8@1236|Gammaproteobacteria,1XWS0@135623|Vibrionales	135623|Vibrionales	S	Thermostable hemolysin	-	-	-	-	-	-	-	-	-	-	-	-	T_hemolysin
k59_260973_1	1088721.NSU_3669	1.24e-16	85.9	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2U17W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS,PAS_4,PAS_7,PAS_9,Response_reg
k59_986540_1	414684.RC1_0132	1.02e-144	423.0	COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,2TRP9@28211|Alphaproteobacteria,2JQM7@204441|Rhodospirillales	204441|Rhodospirillales	P	Potassium transporter peripheral membrane component	trkA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
k59_1042862_2	861299.J421_3760	4.31e-43	154.0	COG2177@1|root,COG2177@2|Bacteria,1ZTDR@142182|Gemmatimonadetes	142182|Gemmatimonadetes	D	Part of the ABC transporter FtsEX involved in	-	-	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	-
k59_817991_1	1185653.A1A1_01738	9.62e-13	72.8	COG0760@1|root,COG0760@2|Bacteria,1TX3R@1239|Firmicutes,4HC85@91061|Bacilli,26DS6@186818|Planococcaceae	91061|Bacilli	M	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins	prsA	-	5.2.1.8	ko:K01802,ko:K07533	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_3,Trigger_C
k59_1207071_1	926569.ANT_27070	3.35e-40	152.0	COG0577@1|root,COG4591@1|root,COG0577@2|Bacteria,COG4591@2|Bacteria,2G6IW@200795|Chloroflexi	200795|Chloroflexi	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_205059_1	757424.Hsero_4345	2.86e-28	116.0	COG0477@1|root,COG2814@2|Bacteria,1MX2P@1224|Proteobacteria,2VIIJ@28216|Betaproteobacteria,4787F@75682|Oxalobacteraceae	28216|Betaproteobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_595132_1	1158608.I583_01220	3.15e-22	94.7	COG0082@1|root,COG0082@2|Bacteria,1TQ40@1239|Firmicutes,4HA0H@91061|Bacilli,4B0A6@81852|Enterococcaceae	91061|Bacilli	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
k59_595132_2	706587.Desti_1326	6.55e-12	69.7	COG0169@1|root,COG0169@2|Bacteria,1MVH4@1224|Proteobacteria,42N54@68525|delta/epsilon subdivisions,2WMGU@28221|Deltaproteobacteria,2MRP9@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
k59_1374826_1	314262.MED193_21951	1.02e-15	82.0	COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,2TXAW@28211|Alphaproteobacteria,2P3FT@2433|Roseobacter	28211|Alphaproteobacteria	S	metal-dependent hydrolase with the TIM-barrel fold	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_1152555_1	1121904.ARBP01000026_gene635	1.11e-56	197.0	COG0457@1|root,COG0457@2|Bacteria,4NDTY@976|Bacteroidetes	976|Bacteroidetes	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,HEAT_2,Paired_CXXCH_1,TPR_19,TPR_8
k59_95310_1	1484460.JSWG01000015_gene1164	1.02e-30	122.0	COG2072@1|root,COG2072@2|Bacteria,4NGC0@976|Bacteroidetes,1HYPQ@117743|Flavobacteriia	976|Bacteroidetes	P	flavoprotein involved in K transport	-	-	-	ko:K07222	-	-	-	-	ko00000	-	-	-	Pyr_redox_3
k59_1761501_1	1038858.AXBA01000010_gene2761	1.47e-25	109.0	COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria,3F0D9@335928|Xanthobacteraceae	28211|Alphaproteobacteria	EQ	Hydantoinase/oxoprolinase N-terminal region	-	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
k59_261027_1	269797.Mbar_A1866	5.65e-50	169.0	COG1712@1|root,arCOG00254@2157|Archaea,2XUNA@28890|Euryarchaeota,2NBJI@224756|Methanomicrobia	224756|Methanomicrobia	F	Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate	nadX	-	1.4.1.21	ko:K06989	ko00760,ko01100,map00760,map01100	-	R07407,R07410	RC02566	ko00000,ko00001,ko01000	-	-	-	DUF108,NAD_binding_3
k59_818047_1	1416759.AYMR01000018_gene2071	1.01e-28	119.0	COG0215@1|root,COG0215@2|Bacteria,2GJF2@201174|Actinobacteria,4FK3Z@85023|Microbacteriaceae	201174|Actinobacteria	J	cysteine-tRNA ligase activity	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
k59_319108_1	869210.Marky_1515	3.16e-26	107.0	COG0517@1|root,COG1125@1|root,COG0517@2|Bacteria,COG1125@2|Bacteria,1WJN3@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	COGs COG1125 ABC-type proline glycine betaine transport systems ATPase components	-	-	-	ko:K05847	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	ABC_tran,CBS
k59_818050_1	318996.AXAZ01000025_gene2362	3.36e-76	243.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2TQKF@28211|Alphaproteobacteria,3JT38@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	COG4584 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,rve
k59_1429652_1	1121403.AUCV01000062_gene3696	1.87e-52	187.0	COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,42N4X@68525|delta/epsilon subdivisions,2WIPR@28221|Deltaproteobacteria,2MI69@213118|Desulfobacterales	28221|Deltaproteobacteria	D	DNA segregation ATPase, FtsK SpoIIIE family	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
k59_762228_1	278957.ABEA03000070_gene2930	4.99e-21	90.5	COG1899@1|root,COG1899@2|Bacteria,46T9G@74201|Verrucomicrobia,3K7VQ@414999|Opitutae	414999|Opitutae	O	Deoxyhypusine synthase	-	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
k59_762228_2	290397.Adeh_1896	6.72e-39	145.0	COG1166@1|root,COG1166@2|Bacteria,1MU80@1224|Proteobacteria,42M2B@68525|delta/epsilon subdivisions,2WJDZ@28221|Deltaproteobacteria,2YTWQ@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the biosynthesis of agmatine from arginine	speA	-	4.1.1.19	ko:K01585	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N
k59_986614_1	383372.Rcas_2451	1.28e-69	222.0	COG0444@1|root,COG0444@2|Bacteria,2G893@200795|Chloroflexi	200795|Chloroflexi	P	TIGRFAM oligopeptide dipeptide ABC transporter, ATPase subunit	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_261043_1	861299.J421_3111	9.88e-24	99.0	COG0524@1|root,COG0524@2|Bacteria,1ZSUT@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
k59_261043_2	861299.J421_3112	4.55e-17	80.9	COG0150@1|root,COG0150@2|Bacteria,1ZSQJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	AIR synthase related protein, C-terminal domain	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
k59_708292_1	70601.3257043	2.4e-47	167.0	COG0215@1|root,arCOG00486@2157|Archaea,2XTRY@28890|Euryarchaeota,243CK@183968|Thermococci	183968|Thermococci	J	Cysteinyl-tRNA synthetase	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
k59_595195_1	309801.trd_0579	2.59e-37	146.0	COG1529@1|root,COG1529@2|Bacteria,2GBUE@200795|Chloroflexi,27Z0K@189775|Thermomicrobia	189775|Thermomicrobia	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_595204_1	1330700.JQNC01000003_gene51	5.26e-24	105.0	COG4585@1|root,COG4585@2|Bacteria,1WJNH@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GAF_3,HATPase_c,HisKA_3,PAS,PAS_4,PAS_8
k59_1208917_1	102129.Lepto7375DRAFT_2687	0.000144	47.4	COG2319@1|root,COG3629@1|root,COG2319@2|Bacteria,COG3629@2|Bacteria,1FZVW@1117|Cyanobacteria,1H7R4@1150|Oscillatoriales	1117|Cyanobacteria	K	Wd40 repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,NACHT,NB-ARC,Pentapeptide,WD40
k59_1208917_2	926569.ANT_09200	2.14e-31	121.0	COG0568@1|root,COG0568@2|Bacteria,2G5W3@200795|Chloroflexi	200795|Chloroflexi	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_819964_1	240015.ACP_0872	4.93e-31	127.0	COG0577@1|root,COG0577@2|Bacteria,3Y36E@57723|Acidobacteria,2JHJ3@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_710177_1	234267.Acid_6259	1.7e-66	220.0	COG1321@1|root,COG1321@2|Bacteria	2|Bacteria	K	iron dependent repressor	nagC	-	-	ko:K02003,ko:K02565,ko:K15545	-	M00258	-	-	ko00000,ko00002,ko02000,ko03000	3.A.1	-	-	HTH_IclR,MarR,ROK
k59_1599058_1	987059.RBXJA2T_13384	2.27e-75	253.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VI3F@28216|Betaproteobacteria,1KJIC@119065|unclassified Burkholderiales	28216|Betaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_206678_1	1121015.N789_05045	9.2e-115	340.0	COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,1RR68@1236|Gammaproteobacteria,1X46A@135614|Xanthomonadales	135614|Xanthomonadales	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Mob_synth_C,Radical_SAM
k59_1711434_1	679192.HMPREF9013_0463	1.81e-30	125.0	COG0744@1|root,COG0744@2|Bacteria,1TPM5@1239|Firmicutes,3VP75@526524|Erysipelotrichia	526524|Erysipelotrichia	M	Psort location Extracellular, score	ponA	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	FIVAR,Transgly,Transpeptidase
k59_1599075_1	518766.Rmar_2194	3.74e-73	235.0	COG0160@1|root,COG0160@2|Bacteria,4NGPB@976|Bacteroidetes,1FITF@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	lat	-	2.6.1.36	ko:K03918	ko01100,map01100	-	R00457	RC00006,RC00062	ko00000,ko01000,ko01007	-	-	-	Aminotran_3
k59_321116_1	41875.XP_007508232.1	1.28e-28	118.0	COG0107@1|root,KOG0623@2759|Eukaryota,37JTY@33090|Viridiplantae,34HH5@3041|Chlorophyta	3041|Chlorophyta	E	Belongs to the HisA HisF family	-	-	-	ko:K01663	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase,His_biosynth
k59_430593_1	485913.Krac_12473	2.14e-06	48.5	COG0183@1|root,COG0183@2|Bacteria,2G5YW@200795|Chloroflexi	200795|Chloroflexi	I	Belongs to the thiolase family	-	-	-	-	-	-	-	-	-	-	-	-	Thiolase_C,Thiolase_N
k59_430593_2	1196323.ALKF01000174_gene1791	3.78e-49	165.0	COG1250@1|root,COG1250@2|Bacteria,1TSZI@1239|Firmicutes,4HBK3@91061|Bacilli,26UKH@186822|Paenibacillaceae	91061|Bacilli	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
k59_488397_1	502025.Hoch_5216	2.19e-19	90.9	COG1589@1|root,COG1589@2|Bacteria,1RDX7@1224|Proteobacteria,42VCZ@68525|delta/epsilon subdivisions,2WRVM@28221|Deltaproteobacteria,2YVR5@29|Myxococcales	28221|Deltaproteobacteria	D	Cell division protein FtsQ	ftsQ	-	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
k59_988603_1	1265313.HRUBRA_00224	8.57e-45	162.0	28IUR@1|root,2Z8TE@2|Bacteria,1NW7C@1224|Proteobacteria,1RP4W@1236|Gammaproteobacteria,1J6EN@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_375342_1	861299.J421_0370	5.72e-80	244.0	COG1028@1|root,COG1028@2|Bacteria,1ZT4H@142182|Gemmatimonadetes	142182|Gemmatimonadetes	IQ	KR domain	-	-	1.1.1.127	ko:K00065	ko00040,map00040	-	R01542	RC00089	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
k59_488398_2	1313421.JHBV01000014_gene3803	5.26e-37	131.0	COG1611@1|root,COG1611@2|Bacteria,4NGWU@976|Bacteroidetes	976|Bacteroidetes	S	Belongs to the LOG family	yvdD	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
k59_97260_2	794903.OPIT5_07170	1.68e-12	65.1	COG1366@1|root,COG1366@2|Bacteria,46T72@74201|Verrucomicrobia	74201|Verrucomicrobia	T	STAS domain	-	-	-	-	-	-	-	-	-	-	-	-	STAS
k59_430603_1	565045.NOR51B_680	2.2e-94	294.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,1RMIT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Gamma-glutamyltransferase	ggt_1	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k59_1267415_1	1051646.VITU9109_14061	1.22e-34	134.0	COG0265@1|root,COG3291@1|root,COG0265@2|Bacteria,COG3291@2|Bacteria,1R6VW@1224|Proteobacteria,1SNEA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Pkd domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_206697_1	1193181.BN10_560059	4.6e-48	166.0	COG0462@1|root,COG0462@2|Bacteria,2GKR2@201174|Actinobacteria,4FFIH@85021|Intrasporangiaceae	201174|Actinobacteria	EF	Ribose-phosphate pyrophosphokinase	prs_1	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
k59_97282_1	414684.RC1_2306	3.04e-66	221.0	COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,2TRPB@28211|Alphaproteobacteria,2JPWI@204441|Rhodospirillales	204441|Rhodospirillales	H	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3,DUF3646
k59_820031_1	1541065.JRFE01000009_gene4548	9.92e-33	119.0	COG3415@1|root,COG3415@2|Bacteria,1GA2F@1117|Cyanobacteria	1117|Cyanobacteria	L	Homeodomain-like domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32
k59_820031_2	653733.Selin_2484	9.22e-25	101.0	COG3335@1|root,COG3335@2|Bacteria	2|Bacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
k59_1209007_1	1380390.JIAT01000013_gene123	4.32e-77	254.0	COG2267@1|root,COG4671@1|root,COG2267@2|Bacteria,COG4671@2|Bacteria	2|Bacteria	I	Glycosyl Transferase	yvaM	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Glyco_tran_28_C,Hydrolase_4
k59_1322137_1	1249627.D779_1468	5.74e-43	152.0	COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,1RP04@1236|Gammaproteobacteria,1WW77@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transferase
k59_430650_1	714961.BFZC1_09025	3.37e-09	62.8	COG4177@1|root,COG4177@2|Bacteria,1TPMZ@1239|Firmicutes,4HBB8@91061|Bacilli,3IX4X@400634|Lysinibacillus	91061|Bacilli	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_430650_2	1126627.BAWE01000006_gene6568	0.000182	44.3	COG0559@1|root,COG0559@2|Bacteria,1MXGK@1224|Proteobacteria,2TVKT@28211|Alphaproteobacteria,3JSJG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
k59_97316_1	1042376.AFPK01000074_gene2390	3.15e-53	179.0	COG2152@1|root,COG2152@2|Bacteria,4NG7B@976|Bacteroidetes,1IIR4@117743|Flavobacteriia	976|Bacteroidetes	G	beta-1,4-mannooligosaccharide phosphorylase	-	-	2.4.1.339,2.4.1.340	ko:K20885	-	-	R11397,R11398	RC00049,RC02748	ko00000,ko01000	-	GH130	-	Glyco_hydro_130
k59_1541697_1	1459636.NTE_01850	7.09e-63	211.0	COG1028@1|root,arCOG01259@2157|Archaea,41S7V@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_262874_1	1463820.JOGW01000022_gene358	5.99e-39	140.0	COG2041@1|root,COG2041@2|Bacteria,2GMG2@201174|Actinobacteria	201174|Actinobacteria	M	Oxidoreductase molybdopterin binding	-	-	-	-	-	-	-	-	-	-	-	-	Mo-co_dimer,Oxidored_molyb
k59_262874_2	1123229.AUBC01000008_gene518	5.76e-17	77.8	COG3703@1|root,COG3703@2|Bacteria,1QA7D@1224|Proteobacteria,2U7C6@28211|Alphaproteobacteria,3JSG9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides	chaC	-	-	ko:K07232	-	-	-	-	ko00000	-	-	-	ChaC
k59_1541705_1	1121890.AUDO01000001_gene859	2.15e-14	78.2	COG1629@1|root,COG4771@2|Bacteria,4NF66@976|Bacteroidetes,1HXWA@117743|Flavobacteriia,2NTUQ@237|Flavobacterium	976|Bacteroidetes	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
k59_596988_1	1032480.MLP_51790	6.9e-29	120.0	COG2909@1|root,COG2909@2|Bacteria,2I50W@201174|Actinobacteria,4DPMG@85009|Propionibacteriales	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	ko:K03556	-	-	-	-	ko00000,ko03000	-	-	-	AAA_16,GerE
k59_1541707_1	1089551.KE386572_gene1375	8.14e-21	97.8	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,4BPN0@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE4,EAL,GGDEF,PAS,PAS_4,PAS_9
k59_1209072_1	1267534.KB906756_gene652	7.72e-08	60.1	COG3852@1|root,COG3852@2|Bacteria,3Y3JR@57723|Acidobacteria,2JIY1@204432|Acidobacteriia	204432|Acidobacteriia	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
k59_934370_1	111105.HR09_02070	1.1e-19	92.8	COG0037@1|root,COG0037@2|Bacteria,4NEJS@976|Bacteroidetes,2FP2A@200643|Bacteroidia,22X8C@171551|Porphyromonadaceae	976|Bacteroidetes	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,B3_4,TilS_C
k59_541955_1	556269.ACDQ01000002_gene1017	1.15e-46	152.0	COG0292@1|root,COG0292@2|Bacteria,1RGU2@1224|Proteobacteria,2VRWF@28216|Betaproteobacteria,474B4@75682|Oxalobacteraceae	28216|Betaproteobacteria	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	-	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
k59_541955_2	322710.Avin_20460	4.75e-13	70.9	COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,1RN22@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iJN746.PP_2469	Phe_tRNA-synt_N,tRNA-synt_2d
k59_668714_2	1382306.JNIM01000001_gene4120	5.92e-14	73.6	COG0558@1|root,COG0558@2|Bacteria,2G6RT@200795|Chloroflexi	200795|Chloroflexi	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
k59_779857_1	1121926.AXWO01000013_gene2177	3.05e-97	311.0	COG3533@1|root,COG3533@2|Bacteria,2GM60@201174|Actinobacteria	201174|Actinobacteria	G	protein conserved in bacteria	-	-	-	ko:K09955	-	-	-	-	ko00000	-	-	-	DUF1793,DUF4964,DUF4965,DUF5127,Glyco_hydro_127,Laminin_G_3,RicinB_lectin_2
k59_1335822_1	1234364.AMSF01000080_gene3055	7.4e-27	109.0	COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,1RPQ7@1236|Gammaproteobacteria,1X2XQ@135614|Xanthomonadales	135614|Xanthomonadales	I	Glycerol-3-phosphate dehydrogenase	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
k59_168340_1	34506.g6252	2.08e-30	125.0	COG0768@1|root,2QR8J@2759|Eukaryota,39SBS@33154|Opisthokonta,3BIR4@33208|Metazoa,3DFVW@33213|Bilateria	33208|Metazoa	M	Penicillin-binding Protein dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	FTSW_RODA_SPOVE,PBP_dimer,SPOUT_MTase,Transpeptidase
k59_1280267_1	526227.Mesil_0256	1.13e-46	171.0	COG0457@1|root,COG1672@1|root,COG2114@1|root,COG0457@2|Bacteria,COG1672@2|Bacteria,COG2114@2|Bacteria	2|Bacteria	T	Pfam Adenylate and Guanylate cyclase catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_16,CHAT,Guanylate_cyc,TPR_10,TPR_12,TPR_8
k59_1169060_1	1249627.D779_2943	5.06e-34	132.0	COG1269@1|root,COG1269@2|Bacteria,1R6B8@1224|Proteobacteria,1RYT3@1236|Gammaproteobacteria,1WX8D@135613|Chromatiales	135613|Chromatiales	U	Belongs to the V-ATPase 116 kDa subunit family	-	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
k59_779884_1	483219.LILAB_02570	5.98e-13	74.3	COG3464@1|root,COG3464@2|Bacteria,1R8B7@1224|Proteobacteria,43BG6@68525|delta/epsilon subdivisions,2X6UH@28221|Deltaproteobacteria,2Z0N1@29|Myxococcales	28221|Deltaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_613085_1	194439.CT1391	1.39e-38	146.0	COG0038@1|root,COG2239@1|root,COG0038@2|Bacteria,COG2239@2|Bacteria,1FD6C@1090|Chlorobi	1090|Chlorobi	P	PFAM CBS domain containing protein	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,Voltage_CLC
k59_835477_1	867903.ThesuDRAFT_01894	2.55e-80	255.0	COG2987@1|root,COG2987@2|Bacteria,1TPZ9@1239|Firmicutes,247YS@186801|Clostridia,3WCXW@538999|Clostridiales incertae sedis	186801|Clostridia	E	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
k59_946713_1	861299.J421_2337	5.74e-78	246.0	COG0624@1|root,COG0624@2|Bacteria,1ZT2K@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
k59_891148_1	395493.BegalDRAFT_2635	9.5e-63	208.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMIW@1236|Gammaproteobacteria,45ZW6@72273|Thiotrichales	72273|Thiotrichales	J	ribonuclease, Rne Rng family	-	-	-	ko:K08301	-	-	-	-	ko00000,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
k59_1647_1	313603.FB2170_07289	2.6e-19	92.0	COG4097@1|root,COG4097@2|Bacteria,4NQ29@976|Bacteroidetes,1I334@117743|Flavobacteriia	976|Bacteroidetes	P	Ferric reductase like transmembrane component	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_8,Ferric_reduct,NAD_binding_1
k59_223913_1	859657.RPSI07_0963	2.7e-44	155.0	COG2321@1|root,COG2321@2|Bacteria,1MU4U@1224|Proteobacteria,2VH8U@28216|Betaproteobacteria,1K376@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Putative neutral zinc metallopeptidase	-	-	-	ko:K07054	-	-	-	-	ko00000	-	-	-	Zn_peptidase
k59_670004_2	1469245.JFBG01000076_gene136	2.48e-63	197.0	COG0822@1|root,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,1S3P1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters	nifU	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
k59_725679_1	1009370.ALO_00960	1.91e-06	54.7	COG1538@1|root,COG1538@2|Bacteria,1TRDS@1239|Firmicutes,4H2S7@909932|Negativicutes	909932|Negativicutes	MU	outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_280805_1	1146883.BLASA_1435	5.31e-55	188.0	COG2368@1|root,COG2368@2|Bacteria,2GKIQ@201174|Actinobacteria,4EV6W@85013|Frankiales	201174|Actinobacteria	Q	4-hydroxyphenylacetate 3-hydroxylase C terminal	-	-	1.14.14.9	ko:K00483	ko00350,ko01120,ko01220,map00350,map01120,map01220	-	R02698,R03299	RC00046	ko00000,ko00001,ko01000	-	-	-	HpaB,HpaB_N
k59_2924_1	345219.Bcoa_0445	1.27e-63	219.0	COG5433@1|root,COG5433@2|Bacteria,1TRZS@1239|Firmicutes,4HUF8@91061|Bacilli,1ZKXP@1386|Bacillus	91061|Bacilli	L	PFAM Transposase, IS4-like	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_4,DDE_Tnp_1_assoc
k59_558632_1	1121106.JQKB01000042_gene2460	1.51e-99	297.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2TU72@28211|Alphaproteobacteria,2JQ3I@204441|Rhodospirillales	204441|Rhodospirillales	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve,rve_3
k59_503215_1	861299.J421_1872	7.43e-135	399.0	COG2303@1|root,COG2303@2|Bacteria	2|Bacteria	E	choline dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2,GMC_oxred_C,GMC_oxred_N
k59_614329_2	1385510.N781_14050	9.04e-05	44.7	COG1115@1|root,COG1115@2|Bacteria,1TNZP@1239|Firmicutes,4H9SZ@91061|Bacilli,2Y95E@289201|Pontibacillus	91061|Bacilli	U	Transporter	agcS	-	-	ko:K03310	-	-	-	-	ko00000	2.A.25	-	-	Na_Ala_symp
k59_169636_1	1117379.BABA_03999	2.22e-21	96.7	COG0146@1|root,COG0146@2|Bacteria,1U1N7@1239|Firmicutes,4HBKB@91061|Bacilli,1ZDFI@1386|Bacillus	91061|Bacilli	EQ	COG0146 N-methylhydantoinase B acetone carboxylase, alpha subunit	-	-	3.5.2.14,6.4.1.6	ko:K01474,ko:K10854	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
k59_169636_2	359.CN09_33440	2.49e-16	79.0	COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria,4B7WC@82115|Rhizobiaceae	28211|Alphaproteobacteria	EQ	N-methylhydantoinase A acetone carboxylase, beta subunit	-	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
k59_1559448_1	356851.JOAN01000021_gene2363	8.4e-30	111.0	COG0346@1|root,COG0346@2|Bacteria,2IMDZ@201174|Actinobacteria,4DFP1@85008|Micromonosporales	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	ko:K07032	-	-	-	-	ko00000	-	-	-	Glyoxalase
k59_1559452_1	498211.CJA_2769	7.59e-64	211.0	COG3534@1|root,COG3534@2|Bacteria,1PPWJ@1224|Proteobacteria,1RQ0J@1236|Gammaproteobacteria,1FGEM@10|Cellvibrio	1236|Gammaproteobacteria	G	Alpha-L-arabinofuranosidase C-terminus	abfA	-	3.2.1.55	ko:K01209	ko00520,map00520	-	R01762	-	ko00000,ko00001,ko01000	-	GH51	-	Alpha-L-AF_C
k59_670038_1	1380394.JADL01000011_gene4019	5.18e-59	194.0	COG2175@1|root,COG2175@2|Bacteria,1MV5K@1224|Proteobacteria,2TQTZ@28211|Alphaproteobacteria,2JSGW@204441|Rhodospirillales	204441|Rhodospirillales	Q	Taurine catabolism dioxygenase TauD, TfdA family	tauD	-	1.14.11.17	ko:K03119,ko:K22303	ko00430,ko00920,map00430,map00920	-	R05320	RC01331	ko00000,ko00001,ko01000	-	-	-	TauD
k59_1448433_1	118161.KB235922_gene3053	3.41e-28	115.0	COG0523@1|root,COG1595@1|root,COG0523@2|Bacteria,COG1595@2|Bacteria,1GD8T@1117|Cyanobacteria	1117|Cyanobacteria	K	Contains a Cobalamin (vitamin B12) biosynthesis domain, cobW domain	-	-	-	-	-	-	-	-	-	-	-	-	CobW_C,cobW
k59_836686_1	1313172.YM304_35560	4.45e-93	288.0	COG1008@1|root,COG1008@2|Bacteria,2GKBN@201174|Actinobacteria,4CMUB@84992|Acidimicrobiia	201174|Actinobacteria	C	Protein synonym NADH dehydrogenase I subunit M	nuoM2	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_280847_1	1317118.ATO8_03641	1.84e-91	276.0	COG4927@1|root,COG4927@2|Bacteria,1MY0W@1224|Proteobacteria,2TTM1@28211|Alphaproteobacteria,4KM3H@93682|Roseivivax	28211|Alphaproteobacteria	S	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	AAT
k59_558658_2	1179773.BN6_20990	4.62e-52	170.0	COG0745@1|root,COG0745@2|Bacteria,2GMG9@201174|Actinobacteria,4E1D6@85010|Pseudonocardiales	201174|Actinobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
k59_392049_1	999425.HMPREF9186_01006	5.97e-25	107.0	COG1131@1|root,COG1131@2|Bacteria,1TPJE@1239|Firmicutes,4HB5U@91061|Bacilli	91061|Bacilli	V	ABC transporter	drrA	-	-	ko:K01990,ko:K11050	ko02010,map02010	M00254,M00298	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.130	-	-	ABC_tran,DUF4162
k59_2965_1	926569.ANT_14150	5.56e-54	181.0	COG0449@1|root,COG0449@2|Bacteria	2|Bacteria	M	glutamine-fructose-6-phosphate transaminase (isomerizing) activity	-	-	2.6.1.16,5.3.1.8,5.3.1.9	ko:K00820,ko:K15916	ko00010,ko00030,ko00051,ko00250,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko04931,map00010,map00030,map00051,map00250,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map04931	M00001,M00004,M00114	R00768,R01819,R02739,R02740,R03321	RC00010,RC00163,RC00376,RC00563,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	SIS
k59_1726237_1	73044.JNXP01000031_gene5482	9.29e-80	251.0	COG0044@1|root,COG0044@2|Bacteria,2GK4A@201174|Actinobacteria	201174|Actinobacteria	F	Dihydropyrimidinase	hyuA	-	3.5.2.2	ko:K01464	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R02269,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Amidohydro_1
k59_58507_1	439235.Dalk_3693	7.28e-31	123.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,42N5S@68525|delta/epsilon subdivisions,2WIUS@28221|Deltaproteobacteria,2MHQU@213118|Desulfobacterales	28221|Deltaproteobacteria	T	adenylyl cyclase class-3 4 guanylyl cyclase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
k59_336313_1	1380391.JIAS01000015_gene231	6.82e-14	69.7	COG3346@1|root,COG3346@2|Bacteria,1MWWG@1224|Proteobacteria,2U0N5@28211|Alphaproteobacteria,2JSD9@204441|Rhodospirillales	204441|Rhodospirillales	S	SURF1-like protein	-	-	-	ko:K14998	-	-	-	-	ko00000,ko03029	3.D.4.8	-	-	SURF1
k59_336313_2	1101191.KI912577_gene2428	8.59e-34	129.0	COG2317@1|root,COG2317@2|Bacteria,1MW7T@1224|Proteobacteria,2TSMY@28211|Alphaproteobacteria,1JS04@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues	-	-	3.4.17.19	ko:K01299	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M32
k59_1670722_1	1231391.AMZF01000063_gene1102	8.69e-38	145.0	COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,2VMRE@28216|Betaproteobacteria,3T2HR@506|Alcaligenaceae	28216|Betaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
k59_1337171_1	926569.ANT_00380	5.7e-30	117.0	2ANS9@1|root,31DS7@2|Bacteria,2G7CA@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_392088_1	1306174.JODP01000018_gene4374	3.52e-10	64.3	COG0366@1|root,COG0366@2|Bacteria,2GIV1@201174|Actinobacteria	201174|Actinobacteria	G	trehalose synthase	-	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Malt_amylase_C
k59_392088_2	272623.L117718	6.5e-10	60.1	COG1940@1|root,COG1940@2|Bacteria,1TQU4@1239|Firmicutes,4HA1C@91061|Bacilli,1YC3G@1357|Lactococcus	91061|Bacilli	GK	ROK family	scrK	-	2.7.1.4	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	-	R00760,R00867,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	ROK
k59_1615044_1	1121904.ARBP01000003_gene6372	1.11e-82	261.0	COG2382@1|root,COG2382@2|Bacteria,4NGBK@976|Bacteroidetes,47K7D@768503|Cytophagia	976|Bacteroidetes	P	esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
k59_58539_1	443144.GM21_3706	3.11e-21	98.6	COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,42PFN@68525|delta/epsilon subdivisions,2WJVD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	glycosyltransferase 36 associated	-	-	2.4.1.20	ko:K00702,ko:K13688	ko00500,ko01100,map00500,map01100	-	R00952	RC00049	ko00000,ko00001,ko01000,ko01003	-	GH94,GT36,GT84	-	Glyco_hydro_36,Glyco_transf_36,Glycoamylase
k59_58543_1	243090.RB12994	8.93e-30	123.0	COG1142@1|root,COG1142@2|Bacteria,2J1KZ@203682|Planctomycetes	203682|Planctomycetes	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_7
k59_1559519_1	1399774.JDWH01000001_gene2553	1.12e-47	165.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,1RVSD@1236|Gammaproteobacteria,3X0W9@547|Enterobacter	1236|Gammaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_1114960_1	935548.KI912159_gene5420	2.6e-57	194.0	COG2114@1|root,COG2267@1|root,COG2114@2|Bacteria,COG2267@2|Bacteria,1QU5X@1224|Proteobacteria,2TW12@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Guanylate_cyc
k59_447764_1	269800.Tfu_1407	9.6e-34	130.0	COG0568@1|root,COG0568@2|Bacteria,2ID1P@201174|Actinobacteria,4EGBU@85012|Streptosporangiales	201174|Actinobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_1448500_1	1458427.BAWN01000048_gene2135	2.68e-46	165.0	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,2VI2V@28216|Betaproteobacteria,4A9Q6@80864|Comamonadaceae	28216|Betaproteobacteria	E	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
k59_781248_1	1286093.C266_06434	2.16e-34	130.0	COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,2VI0E@28216|Betaproteobacteria,1K4KX@119060|Burkholderiaceae	28216|Betaproteobacteria	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	HTH_38,rve
k59_336350_1	234267.Acid_3204	2.07e-66	226.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR,Sortilin-Vps10
k59_392114_1	1192868.CAIU01000020_gene2882	1.48e-08	54.3	COG2057@1|root,COG2057@2|Bacteria,1MWW1@1224|Proteobacteria,2VGKV@28211|Alphaproteobacteria,43RPU@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	I	Coenzyme A transferase	pcaJ	-	2.8.3.6	ko:K01032	ko00362,ko01100,ko01120,map00362,map01100,map01120	-	R02990	RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_trans
k59_392114_2	762376.AXYL_05951	4.69e-55	179.0	COG1788@1|root,COG1788@2|Bacteria,1MVEI@1224|Proteobacteria,2VIR2@28216|Betaproteobacteria,3T2ZD@506|Alcaligenaceae	28216|Betaproteobacteria	I	3-oxoadipate CoA-transferase	pcaI	-	2.8.3.6	ko:K01031	ko00362,ko01100,ko01120,map00362,map01100,map01120	-	R02990	RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_trans
k59_1059156_1	666685.R2APBS1_1385	1.57e-23	101.0	COG1132@1|root,COG1132@2|Bacteria,1MXC2@1224|Proteobacteria,1RZQR@1236|Gammaproteobacteria,1XCEP@135614|Xanthomonadales	135614|Xanthomonadales	V	ABC-type multidrug transport system ATPase and permease	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_tran
k59_1559531_1	1190603.AJYD01000069_gene2335	9.02e-65	220.0	COG2304@1|root,COG2304@2|Bacteria,1QU09@1224|Proteobacteria	1224|Proteobacteria	M	regulator of chromosome condensation, RCC1	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_2,Cadherin,He_PIG,RHS_repeat
k59_558726_1	999630.TUZN_0370	4.21e-24	102.0	COG0500@1|root,arCOG01631@2157|Archaea,2XQ7P@28889|Crenarchaeota	28889|Crenarchaeota	Q	RNA methylase	-	GO:0003674,GO:0003824,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016278,GO:0016279,GO:0016740,GO:0016741,GO:0018022,GO:0018193,GO:0018205,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:0140096,GO:1901564	-	-	-	-	-	-	-	-	-	-	CMAS,DOT1,Methyltransf_25,Methyltransf_31,PrmA
k59_1003707_1	1150626.PHAMO_10168	3.58e-100	297.0	COG0090@1|root,COG0090@2|Bacteria,1MVTD@1224|Proteobacteria,2TTKD@28211|Alphaproteobacteria,2JQ27@204441|Rhodospirillales	204441|Rhodospirillales	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
k59_1003707_2	1238182.C882_0612	9.56e-59	181.0	COG0185@1|root,COG0185@2|Bacteria,1RGYX@1224|Proteobacteria,2U95S@28211|Alphaproteobacteria,2JSNF@204441|Rhodospirillales	204441|Rhodospirillales	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	-	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
k59_1003707_3	570967.JMLV01000010_gene1130	4.15e-09	54.7	COG0091@1|root,COG0091@2|Bacteria,1RH0W@1224|Proteobacteria,2U96X@28211|Alphaproteobacteria,2JSMQ@204441|Rhodospirillales	204441|Rhodospirillales	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
k59_3049_2	243233.MCA2053	1.45e-64	211.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,1RNXA@1236|Gammaproteobacteria,1XE62@135618|Methylococcales	135618|Methylococcales	E	PFAM Aminotransferase, class I	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
k59_280952_1	518766.Rmar_1441	1.9e-96	293.0	COG0577@1|root,COG0577@2|Bacteria,4NEBD@976|Bacteroidetes	976|Bacteroidetes	V	ABC-type antimicrobial peptide transport system, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_781281_1	1274.HX89_09600	3.68e-30	120.0	COG0436@1|root,COG0436@2|Bacteria,2GJ7R@201174|Actinobacteria,1ZVJH@145357|Dermacoccaceae	201174|Actinobacteria	E	Cys/Met metabolism PLP-dependent enzyme	dapC	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	2.6.1.1,2.6.1.17,2.6.1.2,2.6.1.66	ko:K00812,ko:K14260,ko:K14267	ko00220,ko00250,ko00270,ko00290,ko00300,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00290,map00300,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01120,map01130,map01210,map01230	M00016	R00258,R00355,R00694,R00734,R00896,R01215,R02433,R02619,R04475,R05052	RC00006,RC00008,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iNJ661.Rv0858c	Aminotran_1_2
k59_1726333_1	42256.RradSPS_0281	3.6e-28	114.0	COG1277@1|root,COG1277@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
k59_1392663_1	926569.ANT_22890	1.73e-09	62.8	COG1847@1|root,COG1847@2|Bacteria,2G6XH@200795|Chloroflexi	200795|Chloroflexi	S	PFAM single-stranded nucleic acid binding R3H domain protein	-	-	-	ko:K06346	-	-	-	-	ko00000	-	-	-	Jag_N,KH_4,R3H
k59_1003736_1	309807.SRU_0696	2.48e-38	147.0	COG3127@1|root,COG3127@2|Bacteria,4NF16@976|Bacteroidetes,1FIZR@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	Q	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_1670817_1	1382359.JIAL01000001_gene1321	1.74e-41	145.0	COG4658@1|root,COG4658@2|Bacteria	2|Bacteria	C	electron transport chain	-	-	1.6.5.8	ko:K00347,ko:K03614,ko:K21163	ko01059,ko01130,map01059,map01130	M00824	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Complex1_51K,NQR2_RnfD_RnfE,RnfC_N,UnbV_ASPIC,VCBS
k59_1670817_2	1303518.CCALI_01314	1.59e-10	61.6	COG1225@1|root,COG1225@2|Bacteria	2|Bacteria	O	peroxiredoxin activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF4369,Redoxin,Thioredoxin_8,UnbV_ASPIC,VCBS
k59_58598_1	926569.ANT_04700	2.3e-96	292.0	COG4603@1|root,COG4603@2|Bacteria,2G686@200795|Chloroflexi	200795|Chloroflexi	S	Branched-chain amino acid transport system / permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
k59_670166_1	1000569.HMPREF1040_0736	9.47e-43	153.0	COG0682@1|root,COG0682@2|Bacteria,1TPAK@1239|Firmicutes,4H2HB@909932|Negativicutes	909932|Negativicutes	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
k59_1003753_1	525146.Ddes_0613	2.07e-38	143.0	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,42MV0@68525|delta/epsilon subdivisions,2WITK@28221|Deltaproteobacteria,2M7ZM@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	TIGRFAM Lipoprotein releasing system, transmembrane protein, LolC E family	lolC	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
k59_58610_1	402626.Rpic_0564	4.81e-16	79.0	COG1995@1|root,COG3395@1|root,COG1995@2|Bacteria,COG3395@2|Bacteria,1MX5W@1224|Proteobacteria,2VJPJ@28216|Betaproteobacteria,1K05M@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Belongs to the PdxA family	pdxA1	-	1.1.1.262,1.1.1.408,1.1.1.409	ko:K00097,ko:K22024	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1357_C,DUF1537,PdxA
k59_614486_1	1144319.PMI16_01337	1.14e-44	160.0	COG0591@1|root,COG0591@2|Bacteria,1MUBI@1224|Proteobacteria,2VHA8@28216|Betaproteobacteria,475AU@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	putP	-	-	ko:K14392	-	-	-	-	ko00000,ko02000	2.A.21.1	-	-	SSF
k59_503391_2	314265.R2601_10299	2.46e-46	152.0	COG2963@1|root,COG2963@2|Bacteria,1RHKX@1224|Proteobacteria,2U9TV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG2963 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
k59_503391_3	999547.KI421503_gene73	3.15e-146	422.0	COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,1PBHA@1224|Proteobacteria,2TRQF@28211|Alphaproteobacteria,281ZM@191028|Leisingera	28211|Alphaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,rve,rve_3
k59_892623_1	401526.TcarDRAFT_1997	8.16e-60	209.0	COG0841@1|root,COG0841@2|Bacteria,1TQ03@1239|Firmicutes,4H20U@909932|Negativicutes	1239|Firmicutes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_405527_1	281687.CJA06987	1.54e-10	66.6	KOG4569@1|root,KOG4569@2759|Eukaryota,3A0Y5@33154|Opisthokonta,3BZX9@33208|Metazoa,3DG5W@33213|Bilateria,40G6N@6231|Nematoda,1KZ0P@119089|Chromadorea,40YS4@6236|Rhabditida	33208|Metazoa	G	Lipase (class 3)	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_3
k59_349362_1	251221.35211842	1.53e-57	201.0	COG1200@1|root,COG1200@2|Bacteria,1G17H@1117|Cyanobacteria	1117|Cyanobacteria	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
k59_1128929_1	75379.Tint_1127	2.57e-33	128.0	COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,2WEGC@28216|Betaproteobacteria,1KPGC@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07659	ko02020,ko02026,map02020,map02026	M00445,M00742,M00743	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_1739633_1	414684.RC1_0800	2.85e-30	121.0	COG0811@1|root,COG0811@2|Bacteria,1MX5J@1224|Proteobacteria,2TU50@28211|Alphaproteobacteria,2JSBB@204441|Rhodospirillales	204441|Rhodospirillales	U	MotA TolQ ExbB proton channel	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
k59_1739633_2	1298593.TOL_0898	3.24e-10	60.5	COG1196@1|root,COG1196@2|Bacteria,1NGHR@1224|Proteobacteria,1RQW7@1236|Gammaproteobacteria,1XKSV@135619|Oceanospirillales	135619|Oceanospirillales	D	Protein of unknown function (DUF3450)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3450
k59_1517286_1	63737.Npun_R6398	6.15e-49	175.0	COG0025@1|root,COG0025@2|Bacteria,1G1D4@1117|Cyanobacteria,1HJF0@1161|Nostocales	1117|Cyanobacteria	P	PFAM sodium hydrogen exchanger	-	-	-	ko:K03316	-	-	-	-	ko00000	2.A.36	-	-	Na_H_Exchanger
k59_182698_1	926569.ANT_22780	2.72e-53	174.0	COG1047@1|root,COG1047@2|Bacteria,2G744@200795|Chloroflexi	200795|Chloroflexi	G	FKBP-type peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K01802,ko:K03775	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
k59_685985_1	439235.Dalk_5076	1.66e-50	179.0	COG2268@1|root,COG2268@2|Bacteria,1P50K@1224|Proteobacteria,42PJG@68525|delta/epsilon subdivisions,2WQ9J@28221|Deltaproteobacteria,2MMDR@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Flotillin	-	-	-	ko:K07192	ko04910,map04910	-	-	-	ko00000,ko00001,ko03036,ko04131,ko04147	-	-	-	Band_7,Flot
k59_1686047_1	420324.KI912031_gene2811	1.23e-97	291.0	COG0077@1|root,COG0077@2|Bacteria,1MU60@1224|Proteobacteria,2TSUT@28211|Alphaproteobacteria,1JRS9@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	PFAM Prephenate dehydratase	pheA	-	4.2.1.51	ko:K04518	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024	R00691,R01373	RC00360	ko00000,ko00001,ko00002,ko01000	-	-	-	PDT
k59_1074246_1	1173028.ANKO01000195_gene5960	1.35e-19	93.2	COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,1G2UN@1117|Cyanobacteria,1H977@1150|Oscillatoriales	1117|Cyanobacteria	G	Alpha amylase, catalytic domain	-	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	APH,Alpha-amylase,Malt_amylase_C
k59_1741389_1	237368.SCABRO_03924	4.01e-25	108.0	COG1200@1|root,COG1200@2|Bacteria,2IX1Q@203682|Planctomycetes	203682|Planctomycetes	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
k59_128575_1	1434929.X946_3838	1.51e-09	59.7	COG1396@1|root,COG3837@1|root,COG1396@2|Bacteria,COG3837@2|Bacteria,1RBF3@1224|Proteobacteria,2WEAY@28216|Betaproteobacteria,1K4JJ@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_3,HTH_31
k59_1130740_1	1168034.FH5T_01630	2.47e-62	201.0	COG0437@1|root,COG0437@2|Bacteria,4NIEP@976|Bacteroidetes	976|Bacteroidetes	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_11,Fer4_4
k59_1019535_1	1185876.BN8_02773	8.22e-18	85.9	COG2204@1|root,COG2204@2|Bacteria,4NE89@976|Bacteroidetes,47JRM@768503|Cytophagia	976|Bacteroidetes	T	sigma54 specific, transcriptional regulator, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HTH_8,PAS_3,PAS_9,Response_reg,Sigma54_activat
k59_1019535_2	479433.Caci_8399	5.53e-16	78.2	COG0125@1|root,COG0477@1|root,COG0125@2|Bacteria,COG0477@2|Bacteria,2GNTI@201174|Actinobacteria	201174|Actinobacteria	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	MFS_3,Thymidylate_kin
k59_1574764_2	647113.Metok_1350	4.39e-37	147.0	COG0247@1|root,COG0479@1|root,arCOG00333@2157|Archaea,arCOG00963@2157|Archaea,2Y85M@28890|Euryarchaeota,23QEF@183939|Methanococci	183939|Methanococci	C	TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein	-	GO:0006091,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0022900,GO:0022904,GO:0044237,GO:0045333,GO:0055114	1.3.4.1	ko:K18210	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00620	R10660	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG,Fer2_3,Fer4_8
k59_184642_1	1380355.JNIJ01000001_gene3986	5.09e-25	100.0	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,2TSDS@28211|Alphaproteobacteria,3JX26@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_184642_2	1038859.AXAU01000003_gene6198	2.37e-50	170.0	COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,2TT0T@28211|Alphaproteobacteria,3JXYC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_573550_1	1499499.EV06_1047	9.98e-42	150.0	COG0473@1|root,COG0473@2|Bacteria,1G2E4@1117|Cyanobacteria,1MKMA@1212|Prochloraceae	1117|Cyanobacteria	CE	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
k59_1074290_1	504487.JCM19302_956	3.54e-88	281.0	COG1251@1|root,COG1251@2|Bacteria,4NE44@976|Bacteroidetes,1HZ81@117743|Flavobacteriia	976|Bacteroidetes	C	Nitrite reductase NAD(P)H , large subunit	-	-	1.7.1.15	ko:K00362	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2
k59_1686092_1	1463926.JOCA01000031_gene4862	3.44e-29	119.0	COG2409@1|root,COG2409@2|Bacteria,2GJ5A@201174|Actinobacteria	201174|Actinobacteria	F	Drug exporters of the RND superfamily	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	CarboxypepD_reg,MMPL
k59_686042_1	1298867.AUES01000006_gene345	1.04e-63	206.0	COG1319@1|root,COG1319@2|Bacteria,1MUDB@1224|Proteobacteria,2TTJF@28211|Alphaproteobacteria,3JUB1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	CO dehydrogenase flavoprotein C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	CO_deh_flav_C,FAD_binding_5
k59_1463886_1	1120998.AUFC01000011_gene2574	3.66e-06	54.3	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia	186801|Clostridia	NT	methyl-accepting chemotaxis protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,dCache_1,sCache_2,sCache_3_3
k59_1741453_1	997346.HMPREF9374_2799	8.19e-86	269.0	COG1066@1|root,COG1066@2|Bacteria,1TQ7Y@1239|Firmicutes,4H9YC@91061|Bacilli,27BBD@186824|Thermoactinomycetaceae	91061|Bacilli	L	KaiC	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI
k59_686054_1	1128421.JAGA01000002_gene1140	2.49e-99	305.0	COG4799@1|root,COG4799@2|Bacteria,2NQBT@2323|unclassified Bacteria	2|Bacteria	I	Carboxyl transferase domain	mccB	-	2.1.3.15,6.4.1.3,6.4.1.4	ko:K01969,ko:K15052	ko00280,ko00720,ko01100,ko01200,map00280,map00720,map01100,map01200	M00036,M00376	R01859,R04138	RC00097,RC00367,RC00609,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_1185668_1	391165.GbCGDNIH1_2216	1.59e-20	89.7	COG0359@1|root,COG0359@2|Bacteria,1RD0R@1224|Proteobacteria,2TSC9@28211|Alphaproteobacteria,2JS4S@204441|Rhodospirillales	204441|Rhodospirillales	J	binds to the 23S rRNA	rplI	-	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
k59_851311_1	521011.Mpal_2460	1.52e-31	127.0	COG2201@1|root,arCOG04921@2157|Archaea,2Y7RM@28890|Euryarchaeota,2N9F6@224756|Methanomicrobia	224756|Methanomicrobia	N	PAS domain	-	-	2.1.1.80,3.1.1.61	ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,CheR,CheR_N,PAS,PAS_10,PAS_4
k59_1296753_2	316067.Geob_1840	4.07e-19	84.3	COG1801@1|root,COG1801@2|Bacteria,1MU7F@1224|Proteobacteria,43BI9@68525|delta/epsilon subdivisions,2X6WN@28221|Deltaproteobacteria,43U6T@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
k59_796826_1	880073.Calab_1003	2.01e-73	233.0	COG1301@1|root,COG1301@2|Bacteria,2NP6X@2323|unclassified Bacteria	2|Bacteria	U	Sodium:dicarboxylate symporter family	gltP	-	-	ko:K03309	-	-	-	-	ko00000	2.A.23	-	-	SDF
k59_686061_1	1229780.BN381_60088	2.8e-67	226.0	COG0247@1|root,COG2181@1|root,COG0247@2|Bacteria,COG2181@2|Bacteria,2GJ7M@201174|Actinobacteria,3UX6A@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	4Fe-4S dicluster domain	fadF	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
k59_240745_1	1313172.YM304_06150	1.44e-34	132.0	COG4177@1|root,COG4177@2|Bacteria,2GMGD@201174|Actinobacteria,4CNYD@84992|Acidimicrobiia	84992|Acidimicrobiia	U	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_1242862_1	1395571.TMS3_0122970	1.53e-49	176.0	COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,1RMD2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate	betA	-	1.1.99.1	ko:K00108	ko00260,ko01100,map00260,map01100	M00555	R01025	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
k59_1296771_1	526227.Mesil_0962	6.58e-23	97.8	COG0517@1|root,COG0517@2|Bacteria,1WJ0F@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	CBS domain	-	-	-	ko:K04767	-	-	-	-	ko00000	-	-	-	ACT,CBS
k59_908633_1	1121289.JHVL01000007_gene2726	3.01e-24	97.8	2E7HQ@1|root,33207@2|Bacteria,1VT77@1239|Firmicutes,24FMI@186801|Clostridia,36PKH@31979|Clostridiaceae	186801|Clostridia	S	Protein of unknown function (DUF4231)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4231
k59_1741481_1	29306.JOBE01000029_gene1995	9.67e-12	68.2	COG1488@1|root,COG1488@2|Bacteria,2GJAT@201174|Actinobacteria	201174|Actinobacteria	H	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	-	GO:0001666,GO:0003674,GO:0003824,GO:0004516,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009605,GO:0009607,GO:0009628,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016763,GO:0016874,GO:0016879,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0034355,GO:0034641,GO:0034654,GO:0036293,GO:0043094,GO:0043173,GO:0043207,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044403,GO:0044419,GO:0044464,GO:0046483,GO:0046496,GO:0047280,GO:0050896,GO:0051186,GO:0051188,GO:0051701,GO:0051704,GO:0051707,GO:0055086,GO:0070482,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0075136,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	NAPRTase,QRPTase_C
k59_1019616_1	926569.ANT_00250	8.45e-87	263.0	COG1397@1|root,COG1397@2|Bacteria,2G7F9@200795|Chloroflexi	200795|Chloroflexi	O	PFAM ADP-ribosylation Crystallin J1	-	-	3.2.2.24	ko:K05521	-	-	-	-	ko00000,ko01000	-	-	-	ADP_ribosyl_GH
k59_573630_1	861299.J421_2535	4.7e-22	99.4	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_351255_1	1026882.MAMP_00769	1.08e-45	166.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,45ZWV@72273|Thiotrichales	72273|Thiotrichales	E	Glutamate synthase	gltB	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_1741510_2	926569.ANT_24750	4.04e-38	135.0	COG2010@1|root,COG2010@2|Bacteria,2G7FH@200795|Chloroflexi	200795|Chloroflexi	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
k59_741330_2	929712.KI912613_gene4570	7.85e-07	53.1	COG0235@1|root,COG0235@2|Bacteria,2IJ2Q@201174|Actinobacteria,4CTXV@84995|Rubrobacteria	84995|Rubrobacteria	G	Class II Aldolase and Adducin N-terminal domain	-	-	-	ko:K10622	ko00362,ko00622,ko01120,ko01220,map00362,map00622,map01120,map01220	M00539	R02763,R05377	RC00779	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase_II
k59_1574873_1	926569.ANT_17320	2.52e-50	169.0	29XJU@1|root,30JAW@2|Bacteria,2G9DS@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_629193_1	926569.ANT_04950	8.64e-95	289.0	COG0183@1|root,COG0183@2|Bacteria,2G5YW@200795|Chloroflexi	200795|Chloroflexi	I	Belongs to the thiolase family	-	-	-	-	-	-	-	-	-	-	-	-	Thiolase_C,Thiolase_N
k59_1074391_1	1174528.JH992893_gene5975	1.31e-65	223.0	COG0166@1|root,COG0176@1|root,COG0166@2|Bacteria,COG0176@2|Bacteria,1G15G@1117|Cyanobacteria,1JHXK@1189|Stigonemataceae	1117|Cyanobacteria	G	Transaldolase/Fructose-6-phosphate aldolase	-	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
k59_1296843_1	266117.Rxyl_0920	1.29e-104	314.0	COG0674@1|root,COG0674@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor	porA	GO:0003674,GO:0003824,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016491,GO:0016625,GO:0016903,GO:0019752,GO:0033609,GO:0033611,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:1901575	1.2.7.1,1.2.7.10	ko:K00169,ko:K19070	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
k59_1629794_1	1142394.PSMK_18670	3.41e-102	322.0	COG1048@1|root,COG1048@2|Bacteria,2IY29@203682|Planctomycetes	203682|Planctomycetes	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k59_128743_1	1121413.JMKT01000017_gene426	3.86e-20	93.6	COG1615@1|root,COG1615@2|Bacteria,1MZ5A@1224|Proteobacteria,42M4M@68525|delta/epsilon subdivisions,2WIPI@28221|Deltaproteobacteria,2MEAF@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Uncharacterised protein family (UPF0182)	-	-	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
k59_351282_1	1267533.KB906733_gene3355	4.95e-15	80.1	COG0577@1|root,COG0577@2|Bacteria,3Y3KJ@57723|Acidobacteria	57723|Acidobacteria	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_629209_1	1172186.KB911464_gene4697	2.93e-30	123.0	COG0348@1|root,COG1251@1|root,COG0348@2|Bacteria,COG1251@2|Bacteria,2GJ3U@201174|Actinobacteria,2389K@1762|Mycobacteriaceae	201174|Actinobacteria	C	Forkhead associated domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,Fer2,Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2
k59_240819_2	1242864.D187_007388	5.34e-18	85.9	COG3131@1|root,COG3131@2|Bacteria,1MUNX@1224|Proteobacteria,42QKA@68525|delta/epsilon subdivisions,2WK1I@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)	mdoG	-	-	ko:K03670	-	-	-	-	ko00000	-	-	-	MdoG
k59_1074413_1	999141.GME_13345	9.17e-67	208.0	COG0088@1|root,COG0088@2|Bacteria,1MXPF@1224|Proteobacteria,1RNNK@1236|Gammaproteobacteria,1XH61@135619|Oceanospirillales	135619|Oceanospirillales	J	Forms part of the polypeptide exit tunnel	rplD	-	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
k59_851404_1	272134.KB731324_gene4078	9.25e-68	218.0	COG0399@1|root,COG0399@2|Bacteria,1G3H0@1117|Cyanobacteria,1H8TM@1150|Oscillatoriales	1117|Cyanobacteria	M	Cys/Met metabolism PLP-dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
k59_73791_1	1499967.BAYZ01000028_gene1306	1.26e-91	276.0	COG0559@1|root,COG0559@2|Bacteria,2NP7Z@2323|unclassified Bacteria	2|Bacteria	E	Branched-chain amino acid transport system / permease component	livH	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_1074422_1	1379270.AUXF01000002_gene1585	1.75e-70	235.0	COG0515@1|root,COG0515@2|Bacteria,1ZUMJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
k59_463955_1	395493.BegalDRAFT_2703	1.13e-99	298.0	COG0388@1|root,COG0388@2|Bacteria,1MUUB@1224|Proteobacteria,1RNVZ@1236|Gammaproteobacteria,460VX@72273|Thiotrichales	72273|Thiotrichales	S	Carbon-nitrogen hydrolase	-	-	-	ko:K11206	-	-	-	-	ko00000,ko01000	-	-	-	CN_hydrolase
k59_73805_1	247634.GPB2148_828	1.49e-72	234.0	COG1757@1|root,COG1757@2|Bacteria,1MY5C@1224|Proteobacteria,1RP6I@1236|Gammaproteobacteria,1J53V@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	C4-dicarboxylate anaerobic carrier	mleN	-	-	-	-	-	-	-	-	-	-	-	Na_H_antiporter
k59_908736_1	1125863.JAFN01000001_gene3576	3.61e-38	139.0	COG1740@1|root,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,42MI0@68525|delta/epsilon subdivisions,2WIW4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	TIGRFAM hydrogenase (NiFe) small subunit (hydA)	hyaS	-	1.12.2.1,1.12.99.6	ko:K06282,ko:K18008	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_3332	NiFe_hyd_SSU_C,Oxidored_q6,TAT_signal
k59_741373_1	261292.Nit79A3_2503	8.66e-43	155.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2VK9J@28216|Betaproteobacteria	28216|Betaproteobacteria	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
k59_1185795_1	649831.L083_6622	1.08e-06	51.6	COG1595@1|root,COG1595@2|Bacteria,2GM3E@201174|Actinobacteria,4DB9B@85008|Micromonosporales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
k59_908755_1	926560.KE387023_gene3141	5.24e-22	92.4	2D78S@1|root,32TNJ@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4864)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4864
k59_908755_2	748247.AZKH_0630	0.000488	43.1	COG0741@1|root,COG0741@2|Bacteria,1RAP3@1224|Proteobacteria,2VQXG@28216|Betaproteobacteria,2KWVV@206389|Rhodocyclales	206389|Rhodocyclales	M	COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)	-	-	-	-	-	-	-	-	-	-	-	-	SLT
k59_1574950_1	292459.STH2289	2.05e-84	262.0	COG3328@1|root,COG3328@2|Bacteria,1TP4C@1239|Firmicutes,248UI@186801|Clostridia	186801|Clostridia	L	PFAM transposase, mutator	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_1296903_1	1177154.Y5S_02284	0.000697	47.4	COG3637@1|root,COG3637@2|Bacteria,1RDPZ@1224|Proteobacteria,1S4GQ@1236|Gammaproteobacteria,1XP8B@135619|Oceanospirillales	135619|Oceanospirillales	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl
k59_184840_1	313590.MED134_11756	3.31e-07	56.2	2C852@1|root,32YB2@2|Bacteria,4NM63@976|Bacteroidetes,1I1C4@117743|Flavobacteriia,37DV3@326319|Dokdonia	976|Bacteroidetes	S	Domain of unknown function (DUF4136)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4136
k59_908785_1	1161401.ASJA01000024_gene194	8.71e-51	176.0	COG0845@1|root,COG0845@2|Bacteria,1MW65@1224|Proteobacteria,2VET4@28211|Alphaproteobacteria,43WRW@69657|Hyphomonadaceae	28211|Alphaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_D23
k59_240884_1	686340.Metal_2275	8.11e-100	303.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,1XEUM@135618|Methylococcales	135618|Methylococcales	P	PFAM Ammonium Transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_629283_1	379066.GAU_0646	1.19e-80	245.0	COG1403@1|root,COG1403@2|Bacteria,1ZTF1@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	HNH nucleases	-	-	-	-	-	-	-	-	-	-	-	-	HNH_5
k59_1256524_2	113395.AXAI01000020_gene6304	7.69e-12	65.1	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,2TVGG@28211|Alphaproteobacteria,3JSIB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	AI-2E family transporter	MA20_41055	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
k59_480465_1	1234664.AMRO01000077_gene3330	2.33e-28	118.0	COG0028@1|root,COG0028@2|Bacteria,1TQE8@1239|Firmicutes,4H9VR@91061|Bacilli,1WFU1@129337|Geobacillus	91061|Bacilli	EH	Thiamine pyrophosphate enzyme, central domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_812219_2	1173028.ANKO01000041_gene3223	8.42e-25	102.0	COG0493@1|root,COG0493@2|Bacteria,1G0SD@1117|Cyanobacteria,1H8CN@1150|Oscillatoriales	1117|Cyanobacteria	E	TIGRFAM glutamate synthases, NADH NADPH, small subunit	gltD	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	iJN678.gltD	Fer4_20,Pyr_redox_2
k59_1479760_2	1229780.BN381_350143	8.84e-20	93.2	COG2304@1|root,COG5426@1|root,COG2304@2|Bacteria,COG5426@2|Bacteria	2|Bacteria	D	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	BatA,GATase1_like,VWA,VWA_2,VWA_3
k59_1479761_1	751945.Theos_1845	1.69e-36	135.0	COG4448@1|root,COG4448@2|Bacteria,1WIDX@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	L-asparaginase II	-	-	-	-	-	-	-	-	-	-	-	-	Asparaginase_II
k59_1755793_1	1121918.ARWE01000001_gene3112	3.12e-54	182.0	COG1940@1|root,COG1940@2|Bacteria,1MU94@1224|Proteobacteria,42RF4@68525|delta/epsilon subdivisions,2WPIV@28221|Deltaproteobacteria,43TWB@69541|Desulfuromonadales	28221|Deltaproteobacteria	GK	PFAM ROK family protein	glkA	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
k59_980158_1	861299.J421_2746	1.4e-07	53.9	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_1755803_1	926569.ANT_19910	1.41e-70	222.0	COG3407@1|root,COG3407@2|Bacteria,2G5SQ@200795|Chloroflexi	200795|Chloroflexi	I	GHMP kinases N terminal domain	mvaD	-	4.1.1.33	ko:K01597	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095	R01121	RC00453	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_N
k59_1146649_1	1380394.JADL01000016_gene433	1.18e-83	261.0	COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,2TQZB@28211|Alphaproteobacteria,2JQIH@204441|Rhodospirillales	204441|Rhodospirillales	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
k59_1313575_1	1278073.MYSTI_06233	6.55e-23	98.2	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,42M5E@68525|delta/epsilon subdivisions,2WIV6@28221|Deltaproteobacteria,2YTXT@29|Myxococcales	28221|Deltaproteobacteria	J	Ribonuclease E/G family	cafA	-	-	ko:K08301	-	-	-	-	ko00000,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
k59_1703018_1	1267533.KB906736_gene1071	1.15e-22	101.0	COG0577@1|root,COG0577@2|Bacteria,3Y6B8@57723|Acidobacteria,2JK7N@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_1036540_1	485913.Krac_9327	5.91e-30	120.0	COG3547@1|root,COG3547@2|Bacteria	2|Bacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_89152_1	1292020.H483_0115390	3.73e-07	51.6	COG4961@1|root,COG4961@2|Bacteria,2IS3K@201174|Actinobacteria	201174|Actinobacteria	U	TadE-like protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
k59_1258682_1	1033732.CAHI01000030_gene806	0.000105	43.9	COG0300@1|root,COG0300@2|Bacteria,4NK81@976|Bacteroidetes,2G2FB@200643|Bacteroidia	976|Bacteroidetes	S	Oxidoreductase, short chain dehydrogenase reductase family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_1258682_2	471874.PROSTU_03938	1.69e-13	74.3	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,3Z879@586|Providencia	1236|Gammaproteobacteria	F	DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation	deaD	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003724,GO:0003725,GO:0003727,GO:0003824,GO:0004004,GO:0004386,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006417,GO:0006725,GO:0006807,GO:0006950,GO:0006996,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009266,GO:0009314,GO:0009409,GO:0009628,GO:0009889,GO:0009891,GO:0009892,GO:0009893,GO:0009894,GO:0009895,GO:0009987,GO:0010468,GO:0010501,GO:0010556,GO:0010557,GO:0010604,GO:0010605,GO:0010608,GO:0010628,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0019439,GO:0022607,GO:0022613,GO:0022618,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031328,GO:0031329,GO:0031330,GO:0032268,GO:0032270,GO:0033554,GO:0033592,GO:0034248,GO:0034250,GO:0034622,GO:0034641,GO:0034655,GO:0042254,GO:0042255,GO:0042273,GO:0042623,GO:0043170,GO:0043487,GO:0043488,GO:0043489,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045934,GO:0046483,GO:0046700,GO:0048255,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051246,GO:0051247,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0061013,GO:0065003,GO:0065007,GO:0065008,GO:0070035,GO:0070417,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0097617,GO:0140098,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902369,GO:1902373,GO:1903311,GO:1903312,GO:2000112	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DEADboxA,DbpA,Helicase_C
k59_534152_1	2074.JNYD01000005_gene3238	3.18e-20	94.7	COG1524@1|root,COG1524@2|Bacteria,2HH0Q@201174|Actinobacteria	201174|Actinobacteria	S	PFAM type I phosphodiesterase nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phage_holin_4_2,Phosphodiest
k59_1201216_1	441620.Mpop_3940	1.69e-77	243.0	COG0668@1|root,COG0668@2|Bacteria,1MW7V@1224|Proteobacteria,2TT0A@28211|Alphaproteobacteria,1JSMN@119045|Methylobacteriaceae	28211|Alphaproteobacteria	M	MscS Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
k59_1703053_1	395961.Cyan7425_5120	1.6e-34	137.0	COG1169@1|root,COG1169@2|Bacteria,1G2H4@1117|Cyanobacteria,3KGQN@43988|Cyanothece	1117|Cyanobacteria	HQ	Isochorismate synthase	menF	-	5.4.4.2	ko:K02552	ko00130,ko01053,ko01100,ko01110,ko01130,map00130,map01053,map01100,map01110,map01130	M00116	R01717	RC00588	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_bind
k59_1368466_1	977880.RALTA_A0470	1.39e-23	99.8	COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,2VH15@28216|Betaproteobacteria,1K48F@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
k59_1368466_2	861299.J421_3453	1.32e-22	99.4	COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,1ZSPW@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KT	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	SpoIIE
k59_312620_1	1380391.JIAS01000014_gene2170	5.8e-05	45.4	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2TTBF@28211|Alphaproteobacteria,2JR68@204441|Rhodospirillales	204441|Rhodospirillales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_756461_2	767817.Desgi_3625	3.42e-18	85.5	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia,260MY@186807|Peptococcaceae	186801|Clostridia	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	phoR	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8,sCache_like
k59_199556_1	272630.MexAM1_META1p1682	6.82e-17	85.1	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2TR49@28211|Alphaproteobacteria,1JS8T@119045|Methylobacteriaceae	28211|Alphaproteobacteria	M	PFAM Gamma-glutamyltranspeptidase	ggt	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k59_1479882_1	1206720.BAFQ01000178_gene4593	3.9e-48	158.0	COG0748@1|root,COG0748@2|Bacteria,2I2RZ@201174|Actinobacteria,4G9GC@85025|Nocardiaceae	201174|Actinobacteria	P	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
k59_1258748_1	861299.J421_2150	7.02e-74	239.0	COG2303@1|root,COG2303@2|Bacteria,1ZUQ0@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	GMC oxidoreductase	-	-	1.1.5.9	ko:K19813	ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130	-	R00305	RC00066	ko00000,ko00001,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
k59_1755922_1	326427.Cagg_2749	3.57e-63	199.0	COG0512@1|root,COG0512@2|Bacteria,2G69G@200795|Chloroflexi,376BZ@32061|Chloroflexia	32061|Chloroflexia	EH	TIGRFAM glutamine amidotransferase of anthranilate synthase	-	-	4.1.3.27	ko:K01658	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
k59_1368533_1	1463900.JOIX01000035_gene3769	9.01e-19	86.7	COG1032@1|root,COG1032@2|Bacteria,2IC05@201174|Actinobacteria	201174|Actinobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
k59_1368533_2	1031711.RSPO_c01346	4.87e-14	70.5	COG1611@1|root,COG1611@2|Bacteria,1RD59@1224|Proteobacteria,2VRA6@28216|Betaproteobacteria,1K2M8@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Belongs to the LOG family	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
k59_255589_1	1462527.CCDM010000001_gene2610	2.4e-43	153.0	COG3275@1|root,COG3275@2|Bacteria,1V65C@1239|Firmicutes,4HH77@91061|Bacilli	91061|Bacilli	T	Psort location CytoplasmicMembrane, score	-	-	-	ko:K16923	-	M00582	-	-	ko00000,ko00002,ko02000	3.A.1.28	-	-	ECF_trnsprt
k59_422992_1	526225.Gobs_2208	1.13e-05	49.3	COG0438@1|root,COG0438@2|Bacteria,2GM53@201174|Actinobacteria,4EWAD@85013|Frankiales	201174|Actinobacteria	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
k59_866517_1	309807.SRU_2383	1.76e-52	187.0	COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria,4NERT@976|Bacteroidetes,1FJ3R@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	MU	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	BSP,Bac_surface_Ag,PD40
k59_1368565_1	639282.DEFDS_0906	9.02e-15	73.9	COG1225@1|root,COG1225@2|Bacteria	2|Bacteria	O	peroxiredoxin activity	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
k59_144226_1	1122604.JONR01000011_gene3716	7.08e-14	74.3	COG0642@1|root,COG2205@2|Bacteria,1MUZQ@1224|Proteobacteria,1RMZT@1236|Gammaproteobacteria,1X3FI@135614|Xanthomonadales	135614|Xanthomonadales	T	Histidine kinase	kdpD	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,GAF_3,HATPase_c,HisKA,KdpD,Usp
k59_144226_2	1123368.AUIS01000004_gene195	5.67e-13	65.9	2A8P7@1|root,30XRT@2|Bacteria,1QGKW@1224|Proteobacteria,1SJ7C@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF2934)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2934
k59_1146816_1	1232437.KL662013_gene1359	1.47e-13	75.5	COG4775@1|root,COG5616@1|root,COG4775@2|Bacteria,COG5616@2|Bacteria,1MU0D@1224|Proteobacteria,42MMA@68525|delta/epsilon subdivisions,2WIZB@28221|Deltaproteobacteria,2MIBK@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
k59_1644372_1	420662.Mpe_A0560	6.26e-103	317.0	COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,2VHVY@28216|Betaproteobacteria,1KJ3T@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
k59_1534696_1	562970.Btus_2011	3.34e-35	137.0	COG1529@1|root,COG1529@2|Bacteria,1TP7U@1239|Firmicutes,4HC1W@91061|Bacilli,278QK@186823|Alicyclobacillaceae	91061|Bacilli	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	pucD	-	1.17.1.4	ko:K00087	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU32480	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2
k59_144251_2	935548.KI912159_gene6396	7.5e-45	155.0	COG0454@1|root,COG1846@1|root,COG0454@2|Bacteria,COG1846@2|Bacteria,1MWIC@1224|Proteobacteria,2TRIA@28211|Alphaproteobacteria,43GRS@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,MarR_2
k59_1368597_1	379066.GAU_0394	6e-91	286.0	COG0591@1|root,COG0591@2|Bacteria,1ZT93@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Sodium:solute symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
k59_312752_1	702113.PP1Y_Mpl7012	5.6e-39	147.0	COG1520@1|root,COG2010@1|root,COG1520@2|Bacteria,COG2010@2|Bacteria,1PIDE@1224|Proteobacteria,2TTS3@28211|Alphaproteobacteria,2K3QU@204457|Sphingomonadales	204457|Sphingomonadales	C	PQQ-like domain	-	-	1.1.2.6	ko:K05889	-	-	R03136	-	ko00000,ko01000	-	-	-	Cytochrome_CBB3,PQQ,PQQ_2,PQQ_3
k59_1423725_1	525904.Tter_0474	7.79e-97	315.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,2NP08@2323|unclassified Bacteria	2|Bacteria	E	Glutamate synthase central domain	gltB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016020,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_1090707_1	1111121.HMPREF1247_1361	5.43e-31	124.0	COG0358@1|root,COG0358@2|Bacteria,2GJFX@201174|Actinobacteria,4CUGG@84998|Coriobacteriia	84998|Coriobacteriia	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
k59_1479993_1	1488328.JMCL01000141_gene1340	0.00074	42.7	COG1804@1|root,COG1804@2|Bacteria,1MU4A@1224|Proteobacteria,1RZ73@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	acyl-CoA transferases carnitine dehydratase	-	-	2.8.3.22	ko:K18289	ko00660,map00660	-	R02407,R03154	RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_transf_3
k59_1479993_2	2754.EH55_09265	3.49e-54	183.0	COG0183@1|root,COG0183@2|Bacteria,3TA5D@508458|Synergistetes	508458|Synergistetes	I	Belongs to the thiolase family	-	-	-	-	-	-	-	-	-	-	-	-	Thiolase_C,Thiolase_N
k59_367091_1	47839.CCAU010000005_gene499	1.08e-43	150.0	COG1917@1|root,COG1917@2|Bacteria,2I43Q@201174|Actinobacteria,23AR9@1762|Mycobacteriaceae	201174|Actinobacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_312772_1	1122185.N792_02575	6.74e-11	67.8	COG3725@1|root,COG3725@2|Bacteria,1MYFA@1224|Proteobacteria,1SE2J@1236|Gammaproteobacteria,1X4YH@135614|Xanthomonadales	135614|Xanthomonadales	V	Membrane protein required for beta-lactamase induction	ampE	-	-	ko:K03807	-	-	-	-	ko00000	-	-	-	CobD_Cbib
k59_1313828_1	926562.Oweho_3543	1.02e-31	117.0	COG1443@1|root,COG1443@2|Bacteria,4NFJV@976|Bacteroidetes,1HXIQ@117743|Flavobacteriia,2PAX6@246874|Cryomorphaceae	976|Bacteroidetes	I	NUDIX domain	idi	-	5.3.3.2	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123	RC00455	ko00000,ko00001,ko00002,ko01000	-	-	-	NUDIX
k59_312784_3	1298863.AUEP01000008_gene1247	1.06e-27	110.0	COG0404@1|root,COG0404@2|Bacteria,2I8C4@201174|Actinobacteria,4DTFF@85009|Propionibacteriales	201174|Actinobacteria	E	Glycine cleavage T-protein C-terminal barrel domain	-	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1989,GCV_T,GCV_T_C
k59_1313841_2	660470.Theba_0483	1.15e-24	101.0	COG1670@1|root,COG1670@2|Bacteria,2GCW5@200918|Thermotogae	200918|Thermotogae	J	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
k59_1090756_2	986075.CathTA2_3059	2.88e-32	123.0	COG3342@1|root,COG3342@2|Bacteria,1TS8U@1239|Firmicutes,4HBYK@91061|Bacilli	91061|Bacilli	S	Family of unknown function (DUF1028)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1028,PG_binding_2
k59_925805_1	314260.PB2503_13339	1.14e-86	267.0	COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,2TQZ0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
k59_980450_2	1173027.Mic7113_2371	4.45e-61	197.0	COG2141@1|root,COG2141@2|Bacteria,1G2KI@1117|Cyanobacteria,1HDJK@1150|Oscillatoriales	1117|Cyanobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_1703300_1	1123508.JH636446_gene6253	3.07e-42	148.0	COG1801@1|root,COG1801@2|Bacteria,2IYWM@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
k59_1274934_1	46234.ANA_C12084	1.55e-12	68.9	COG4916@1|root,COG4916@2|Bacteria	2|Bacteria	S	TIR domain	-	-	-	-	-	-	-	-	-	-	-	-	Mrr_cat,SIR2_2,TIR_2
k59_940940_1	370438.PTH_1746	7.7e-27	108.0	COG0416@1|root,COG0416@2|Bacteria,1TPXS@1239|Firmicutes,247KW@186801|Clostridia,2610G@186807|Peptococcaceae	186801|Clostridia	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
k59_1659421_1	498211.CJA_3054	4.08e-121	360.0	COG3497@1|root,COG3497@2|Bacteria,1MX89@1224|Proteobacteria,1RQUU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	tail sheath protein	-	-	-	ko:K06907	-	-	-	-	ko00000	-	-	-	Phage_sheath_1,Phage_sheath_1C
k59_496164_1	1379698.RBG1_1C00001G0857	1.38e-94	290.0	COG5557@1|root,COG5557@2|Bacteria,2NNNQ@2323|unclassified Bacteria	1379698.RBG1_1C00001G0857|-	C	Polysulphide reductase, NrfD	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_268683_1	1379270.AUXF01000002_gene1407	1.99e-08	57.4	COG0079@1|root,COG0079@2|Bacteria,1ZV8F@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	-	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	-
k59_268683_2	1117379.BABA_02030	1.91e-20	89.0	COG0118@1|root,COG0118@2|Bacteria,1TQT0@1239|Firmicutes,4HFXQ@91061|Bacilli,1ZBC4@1386|Bacillus	91061|Bacilli	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	GO:0000105,GO:0000107,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
k59_382607_1	204669.Acid345_4599	5.42e-35	135.0	COG0405@1|root,COG0405@2|Bacteria,3Y2N0@57723|Acidobacteria,2JHK2@204432|Acidobacteriia	204432|Acidobacteriia	E	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k59_437211_1	926569.ANT_05800	1.53e-78	250.0	COG4799@1|root,COG4799@2|Bacteria,2G5IX@200795|Chloroflexi	200795|Chloroflexi	I	PFAM carboxyl transferase	-	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_47368_1	10228.TriadP63003	2.28e-15	79.0	COG0823@1|root,2QPTW@2759|Eukaryota,3968E@33154|Opisthokonta,3BR8I@33208|Metazoa	33208|Metazoa	U	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40
k59_382621_1	1123371.ATXH01000010_gene735	2.06e-112	335.0	COG0538@1|root,COG0538@2|Bacteria,2GH2J@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	Isocitrate/isopropylmalate dehydrogenase	-	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
k59_1605264_2	1121272.KB903272_gene199	1.18e-07	52.8	COG2197@1|root,COG2197@2|Bacteria,2GN80@201174|Actinobacteria,4DDZI@85008|Micromonosporales	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_1384135_1	998674.ATTE01000001_gene508	4.6e-60	201.0	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,1RMN6@1236|Gammaproteobacteria,45ZP9@72273|Thiotrichales	72273|Thiotrichales	P	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
k59_1495650_1	402777.KB235904_gene3192	5.4e-48	175.0	COG0642@1|root,COG2199@1|root,COG3290@1|root,COG2205@2|Bacteria,COG3290@2|Bacteria,COG3706@2|Bacteria,1G13T@1117|Cyanobacteria,1H77Q@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_8,PAS_9,Response_reg
k59_159439_1	1189619.pgond44_09236	1.84e-40	142.0	COG1215@1|root,COG1215@2|Bacteria,4NFM1@976|Bacteroidetes,1HX0G@117743|Flavobacteriia,4C2TG@83612|Psychroflexus	976|Bacteroidetes	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_1329629_1	1046724.KB889897_gene3327	3.08e-47	159.0	COG4314@1|root,COG4314@2|Bacteria,1RCDR@1224|Proteobacteria,1S7G3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	NosL protein	nosL	-	-	ko:K19342	-	-	-	-	ko00000	-	-	-	NosL
k59_657390_1	1499685.CCFJ01000011_gene2046	0.000359	41.6	COG3870@1|root,COG3870@2|Bacteria,1V6NI@1239|Firmicutes,4HIHA@91061|Bacilli,1ZHEA@1386|Bacillus	91061|Bacilli	S	protein conserved in bacteria	yaaQ	-	-	-	-	-	-	-	-	-	-	-	CdAMP_rec
k59_657390_2	1163385.PNWB_v1c2710	1.05e-11	65.5	COG3870@1|root,COG3870@2|Bacteria	2|Bacteria	S	Cyclic-di-AMP receptor	-	-	-	-	-	-	-	-	-	-	-	-	CdAMP_rec
k59_1717468_1	926569.ANT_17590	1.96e-86	283.0	COG3459@1|root,COG3459@2|Bacteria,2G9NQ@200795|Chloroflexi	200795|Chloroflexi	G	Glycosyltransferase 36 associated	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1770815_1	500640.CIT292_10248	3.24e-29	111.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,1RMK8@1236|Gammaproteobacteria,3WXC7@544|Citrobacter	1236|Gammaproteobacteria	P	ATPases associated with a variety of cellular activities	livF	GO:0000166,GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005488,GO:0005524,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008144,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015175,GO:0015179,GO:0015188,GO:0015238,GO:0015318,GO:0015658,GO:0015711,GO:0015801,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015823,GO:0015829,GO:0015849,GO:0015893,GO:0017076,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034220,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0097159,GO:0097367,GO:0098655,GO:0098656,GO:1901265,GO:1901363,GO:1902475,GO:1903714,GO:1903785,GO:1903825,GO:1905039	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	iAPECO1_1312.APECO1_3005,iECs_1301.ECs4301,iSSON_1240.SSON_3692,iUTI89_1310.UTI89_C3961,iYL1228.KPN_03816,iZ_1308.Z4824	ABC_tran,BCA_ABC_TP_C
k59_826706_1	1232683.ADIMK_3344	2.91e-81	252.0	COG2114@1|root,COG2114@2|Bacteria,1QWNC@1224|Proteobacteria,1S3UK@1236|Gammaproteobacteria,468QZ@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1,4.6.1.2	ko:K01768,ko:K01769	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc
k59_994853_1	414684.RC1_1628	1.15e-29	112.0	COG1192@1|root,COG1192@2|Bacteria,1MWRE@1224|Proteobacteria,2TSJZ@28211|Alphaproteobacteria,2JRRK@204441|Rhodospirillales	204441|Rhodospirillales	D	VirC1 protein	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31,CbiA
k59_994853_2	498761.HM1_1518	1.19e-07	52.8	COG0473@1|root,COG0473@2|Bacteria,1TPEM@1239|Firmicutes,24A63@186801|Clostridia	186801|Clostridia	C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
k59_104019_1	251221.35212995	2.13e-20	95.5	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_1438375_1	864051.BurJ1DRAFT_4683	7.81e-33	119.0	COG2165@1|root,COG2165@2|Bacteria,1N1QJ@1224|Proteobacteria,2VTYJ@28216|Betaproteobacteria,1KNTA@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	type II secretion system protein G	-	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
k59_548498_2	1451189.CFAL_06960	1.62e-13	73.6	COG2905@1|root,COG2905@2|Bacteria,2I91C@201174|Actinobacteria,22KWJ@1653|Corynebacteriaceae	201174|Actinobacteria	T	signal-transduction protein containing cAMP-binding and CBS domains	-	-	-	ko:K07182	-	-	-	-	ko00000	-	-	-	CBS,DUF294,DUF294_C,cNMP_binding
k59_1717478_1	1279038.KB907340_gene1445	3.96e-15	79.7	COG0845@1|root,COG0845@2|Bacteria,1MUI8@1224|Proteobacteria,2TSP0@28211|Alphaproteobacteria,2JR7Q@204441|Rhodospirillales	204441|Rhodospirillales	M	COG0845 Membrane-fusion protein	-	-	-	ko:K12542	-	M00330	-	-	ko00000,ko00002,ko02000,ko02044	3.A.1.109.4,8.A.1	-	-	Biotin_lipoyl_2,HlyD,HlyD_3
k59_496203_2	745718.JADT01000025_gene615	0.000374	45.1	COG2304@1|root,COG2304@2|Bacteria,4NF7Y@976|Bacteroidetes,1HYES@117743|Flavobacteriia	976|Bacteroidetes	S	von Willebrand factor, type A	batB	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	BatA,VWA,VWA_2
k59_882730_1	1231391.AMZF01000094_gene122	4.44e-41	151.0	COG0028@1|root,COG0028@2|Bacteria,1MX3Q@1224|Proteobacteria,2VMUI@28216|Betaproteobacteria,3T2PP@506|Alcaligenaceae	28216|Betaproteobacteria	EH	Thiamine pyrophosphate enzyme, central domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_268715_1	1313172.YM304_00360	1.91e-85	283.0	COG1404@1|root,COG1404@2|Bacteria,2GK3D@201174|Actinobacteria	201174|Actinobacteria	O	Belongs to the peptidase S8 family	sbtB	-	-	-	-	-	-	-	-	-	-	-	Big_3_5,Inhibitor_I9,PA,Peptidase_S8
k59_328569_1	313603.FB2170_07984	5.1e-73	245.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,4NF4F@976|Bacteroidetes,1HXEG@117743|Flavobacteriia	976|Bacteroidetes	C	Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg	nifJ	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_1547584_1	1379270.AUXF01000006_gene243	3.27e-66	216.0	COG1109@1|root,COG1109@2|Bacteria,1ZSP6@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Phosphoglucomutase/phosphomannomutase, C-terminal domain	-	-	5.4.2.2,5.4.2.8	ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_496217_1	99598.Cal7507_3161	4.49e-89	280.0	COG0365@1|root,COG0365@2|Bacteria,1G0E7@1117|Cyanobacteria,1HM2H@1161|Nostocales	1117|Cyanobacteria	H	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_1659480_1	314225.ELI_05815	3.01e-41	145.0	COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,2TRAD@28211|Alphaproteobacteria,2K213@204457|Sphingomonadales	204457|Sphingomonadales	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
k59_657435_1	502025.Hoch_0349	1.84e-25	103.0	COG0406@1|root,COG0406@2|Bacteria	2|Bacteria	G	alpha-ribazole phosphatase activity	-	-	3.1.3.3,3.1.3.73,5.4.2.11,5.4.2.12	ko:K01834,ko:K02226,ko:K15634,ko:K22305	ko00010,ko00260,ko00680,ko00860,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map00860,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003,M00122	R00582,R01518,R04594,R11173	RC00017,RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
k59_548520_2	1232683.ADIMK_0317	2.02e-61	196.0	COG1385@1|root,COG1385@2|Bacteria,1MZBG@1224|Proteobacteria,1S0HM@1236|Gammaproteobacteria,464CI@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	-	-	-	-	-	-	-	-	-	-	-	-	Methyltrans_RNA
k59_826764_1	1192034.CAP_4260	2.09e-53	181.0	COG1319@1|root,COG1319@2|Bacteria,1PG5C@1224|Proteobacteria,43EJH@68525|delta/epsilon subdivisions,2X9UI@28221|Deltaproteobacteria,2Z2GS@29|Myxococcales	28221|Deltaproteobacteria	C	CO dehydrogenase flavoprotein C-terminal domain	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
k59_1717508_1	1122194.AUHU01000006_gene574	3.08e-08	59.7	COG4219@1|root,COG4219@2|Bacteria,1PJ0I@1224|Proteobacteria,1RYEX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	KT	BlaR1 peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	DUF3313,Peptidase_M56,TonB_C
k59_1050749_1	391735.Veis_4886	6.23e-54	182.0	COG3335@1|root,COG3335@2|Bacteria,1MW7X@1224|Proteobacteria,2VMDX@28216|Betaproteobacteria,4AAP5@80864|Comamonadaceae	28216|Betaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_23,HTH_29,HTH_32
k59_770104_1	744980.TRICHSKD4_0286	3.65e-71	224.0	COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,2TVQR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	esterase of the alpha-beta hydrolase superfamily	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
k59_1547613_1	1128421.JAGA01000002_gene236	2.55e-05	45.8	COG0180@1|root,COG0180@2|Bacteria,2NNQX@2323|unclassified Bacteria	2|Bacteria	J	tRNA synthetases class I (W and Y)	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
k59_1547613_2	880070.Cycma_4270	2.85e-16	80.9	COG0457@1|root,COG0457@2|Bacteria,4P246@976|Bacteroidetes,47PGN@768503|Cytophagia	976|Bacteroidetes	S	Protein of unknown function (DUF2911)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2911
k59_1438449_1	926550.CLDAP_08530	2.06e-54	186.0	COG1079@1|root,COG1079@2|Bacteria,2G6BT@200795|Chloroflexi	200795|Chloroflexi	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
k59_1438449_2	1064537.AGSO01000002_gene399	5.28e-14	74.7	COG4603@1|root,COG4603@2|Bacteria,2GKAZ@201174|Actinobacteria,4FCGY@85020|Dermabacteraceae	201174|Actinobacteria	S	Branched-chain amino acid transport system / permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
k59_826790_2	699246.HMPREF0868_1398	7.15e-44	158.0	COG3872@1|root,COG3872@2|Bacteria,1TPBU@1239|Firmicutes,25C8E@186801|Clostridia,2683Y@186813|unclassified Clostridiales	186801|Clostridia	S	Protein of unknown function (DUF1385)	prmC	-	-	-	-	-	-	-	-	-	-	-	DUF1385,MTS
k59_1659512_1	1121405.dsmv_2611	1.46e-91	293.0	COG0603@1|root,COG1402@1|root,COG0603@2|Bacteria,COG1402@2|Bacteria,1MXR9@1224|Proteobacteria,42QNA@68525|delta/epsilon subdivisions,2X9RQ@28221|Deltaproteobacteria,2MPA0@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Creatinine amidohydrolase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
k59_104059_1	521096.Tpau_1367	3.86e-30	119.0	COG1012@1|root,COG1012@2|Bacteria,2GJI2@201174|Actinobacteria	201174|Actinobacteria	C	Dehydrogenase	mmsA	-	1.2.1.18,1.2.1.27	ko:K00140	ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200	M00013	R00705,R00706,R00922,R00935	RC00004,RC02723,RC02817	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_104059_2	1449048.JQKU01000005_gene4730	2.83e-96	297.0	COG2801@1|root,COG2801@2|Bacteria,2GJ3V@201174|Actinobacteria,237J7@1762|Mycobacteriaceae	201174|Actinobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	LZ_Tnp_IS481,rve
k59_994914_1	926569.ANT_15720	2.6e-60	201.0	COG0535@1|root,COG0535@2|Bacteria,2G5XT@200795|Chloroflexi	200795|Chloroflexi	C	PFAM Radical SAM domain protein	-	-	-	ko:K22227	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
k59_1547621_1	4113.PGSC0003DMT400019412	2.35e-26	112.0	COG0458@1|root,KOG0370@2759|Eukaryota,37HYE@33090|Viridiplantae,3G8AS@35493|Streptophyta,44CV4@71274|asterids	35493|Streptophyta	EF	Carbamoyl-phosphate synthetase large chain, oligomerisation domain	CARB	GO:0000050,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005951,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009267,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016036,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0019627,GO:0019752,GO:0031667,GO:0031668,GO:0031669,GO:0032991,GO:0033554,GO:0034641,GO:0042594,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_1050778_1	1380394.JADL01000001_gene2484	2.61e-125	372.0	COG1053@1|root,COG1053@2|Bacteria,1MX5A@1224|Proteobacteria,2TV7T@28211|Alphaproteobacteria,2JQSB@204441|Rhodospirillales	28211|Alphaproteobacteria	C	FAD dependent oxidoreductase	-	-	-	ko:K13796	-	-	-	-	ko00000	-	-	-	FAD_binding_2
k59_1275111_1	690585.JNNU01000023_gene2015	5.67e-11	68.6	COG1804@1|root,COG1804@2|Bacteria,1NSWZ@1224|Proteobacteria,2U2UE@28211|Alphaproteobacteria,4BCJ9@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_994924_1	1230476.C207_04401	1.8e-36	134.0	COG0395@1|root,COG0395@2|Bacteria,1QW7F@1224|Proteobacteria,2TR3V@28211|Alphaproteobacteria,3JSTC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Binding-protein-dependent transport system inner membrane component	MA20_03695	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
k59_994924_2	1123023.JIAI01000001_gene7302	0.000236	43.9	COG1175@1|root,COG1175@2|Bacteria,2GJGB@201174|Actinobacteria,4E12E@85010|Pseudonocardiales	201174|Actinobacteria	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025,ko:K15771	ko02010,map02010	M00207,M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.16,3.A.1.1.2	-	-	BPD_transp_1
k59_1329749_1	219305.MCAG_03350	1.04e-83	270.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,4D9SG@85008|Micromonosporales	201174|Actinobacteria	P	Heavy metal translocating P-type atpase	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
k59_770132_1	1043205.AFYF01000045_gene2909	8.76e-41	152.0	COG0768@1|root,COG0768@2|Bacteria,2GJUQ@201174|Actinobacteria,4FE2U@85021|Intrasporangiaceae	201174|Actinobacteria	M	Cell division protein FtsI	pbpA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K05364	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01011	-	-	-	Transpeptidase
k59_437370_1	1144275.COCOR_04279	5.38e-76	242.0	COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,42MG0@68525|delta/epsilon subdivisions,2WJE1@28221|Deltaproteobacteria,2YTVY@29|Myxococcales	28221|Deltaproteobacteria	J	histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
k59_994933_1	1247963.JPHU01000005_gene341	0.000594	43.9	COG2214@1|root,COG2214@2|Bacteria,1PA8G@1224|Proteobacteria,2UWQC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	DnaJ molecular chaperone homology domain	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1384293_1	1121937.AUHJ01000011_gene2875	1.18e-38	144.0	COG2807@1|root,COG2807@2|Bacteria,1NXQ2@1224|Proteobacteria,1RXXM@1236|Gammaproteobacteria,46AA5@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1050797_1	1521187.JPIM01000008_gene2110	1.48e-79	263.0	COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,2G7K6@200795|Chloroflexi,374W8@32061|Chloroflexia	32061|Chloroflexia	G	SMART alpha amylase, catalytic sub domain	-	-	3.2.1.1,3.2.1.20,5.4.99.16	ko:K01187,ko:K05343	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R01557,R02108,R02112,R06087,R06088,R11262	RC00028,RC00049,RC00077,RC01816	ko00000,ko00001,ko01000	-	GH13,GH31	-	Alpha-amylase,Malt_amylase_C
k59_1050797_2	471854.Dfer_0153	1.69e-06	53.1	COG0366@1|root,COG0366@2|Bacteria,4NFMM@976|Bacteroidetes,47KUA@768503|Cytophagia	976|Bacteroidetes	G	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB	glgE	-	2.4.99.16	ko:K16147	ko00500,ko01100,map00500,map01100	-	R09994	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3416
k59_1605418_1	330214.NIDE0003	1.88e-51	183.0	COG0187@1|root,COG0187@2|Bacteria,3J0BB@40117|Nitrospirae	40117|Nitrospirae	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_1547653_1	1449069.JMLO01000045_gene347	1.12e-21	92.0	COG0596@1|root,COG0596@2|Bacteria,2GKJB@201174|Actinobacteria,4FXBS@85025|Nocardiaceae	201174|Actinobacteria	EGP	Alpha/beta hydrolase family	dhmA	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.8.1.5	ko:K01563	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05284,R05367,R05368,R05369,R05370,R07669,R07670	RC01317,RC01340,RC01341,RC02013	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
k59_1547653_2	1107311.Q767_00245	1.01e-16	77.8	COG0262@1|root,COG0262@2|Bacteria,4NPJF@976|Bacteroidetes,1I4ZF@117743|Flavobacteriia,2NXEV@237|Flavobacterium	976|Bacteroidetes	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
k59_1438519_1	395493.BegalDRAFT_2529	1.44e-36	144.0	COG0501@1|root,COG0501@2|Bacteria,1NA37@1224|Proteobacteria,1RY3D@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Zn-dependent protease with chaperone function	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
k59_1605438_2	266835.14021744	1.29e-50	176.0	COG0654@1|root,COG0654@2|Bacteria,1MUN4@1224|Proteobacteria,2TQT8@28211|Alphaproteobacteria,43MFX@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	CH	FAD binding domain	pcpB	-	1.14.13.127,1.14.13.50	ko:K03391,ko:K05712	ko00360,ko00361,ko00364,ko01100,ko01120,ko01220,map00360,map00361,map00364,map01100,map01120,map01220	M00545	R03982,R06786,R06787,R07779	RC00236,RC01932	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
k59_1606772_1	1045009.AFXQ01000017_gene261	2.79e-47	175.0	COG0404@1|root,COG0446@1|root,COG4583@1|root,COG0404@2|Bacteria,COG0446@2|Bacteria,COG4583@2|Bacteria,2IFA6@201174|Actinobacteria,1WASW@1268|Micrococcaceae	201174|Actinobacteria	E	2Fe-2S iron-sulfur cluster binding domain	-	-	1.5.3.1	ko:K00305	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	Fer2_4,GCV_T,GCV_T_C,Pyr_redox_2,SoxG
k59_1276790_1	502025.Hoch_2705	1.51e-100	308.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,42M18@68525|delta/epsilon subdivisions,2WJUK@28221|Deltaproteobacteria,2YU13@29|Myxococcales	28221|Deltaproteobacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	coxA	-	1.10.3.10,1.9.3.1	ko:K02274,ko:K02298	ko00190,ko01100,map00190,map01100	M00155,M00417	R00081,R11335	RC00016,RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.5,3.D.4.6	-	-	COX1
k59_719487_1	1254432.SCE1572_01305	6.66e-81	240.0	COG0346@1|root,COG0346@2|Bacteria,1N08M@1224|Proteobacteria,434NI@68525|delta/epsilon subdivisions,2WYZV@28221|Deltaproteobacteria,2Z10X@29|Myxococcales	28221|Deltaproteobacteria	E	COG0346 Lactoylglutathione lyase and related lyases	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
k59_719493_1	1301100.HG529431_gene1833	1.86e-07	57.8	COG0053@1|root,COG0053@2|Bacteria,1TSGY@1239|Firmicutes,2491V@186801|Clostridia,36ECU@31979|Clostridiaceae	186801|Clostridia	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	fieF	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
k59_1718626_1	479434.Sthe_2879	8.32e-52	174.0	COG2141@1|root,COG2141@2|Bacteria	2|Bacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_719494_1	472759.Nhal_0437	1.79e-70	233.0	COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,1RQ4N@1236|Gammaproteobacteria,1WZX0@135613|Chromatiales	135613|Chromatiales	Q	PFAM multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase_2,Cu-oxidase_3
k59_1107028_1	765913.ThidrDRAFT_2390	3.36e-08	54.3	COG1280@1|root,COG1280@2|Bacteria,1RF18@1224|Proteobacteria,1S4TM@1236|Gammaproteobacteria,1WYI1@135613|Chromatiales	135613|Chromatiales	E	PFAM Lysine exporter protein (LYSE YGGA)	-	-	-	-	-	-	-	-	-	-	-	-	LysE
k59_1064064_3	1332071.L581_1087	1.74e-28	112.0	COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,1RNEW@1236|Gammaproteobacteria,401RZ@613|Serratia	1236|Gammaproteobacteria	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046033,GO:0046040,GO:0046085,GO:0046086,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	iECNA114_1301.ECNA114_4393,iECSF_1327.ECSF_4063,iJN746.PP_4889	Adenylsucc_synt
k59_1120131_1	504472.Slin_4504	3.61e-75	247.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,4NETS@976|Bacteroidetes,47K8N@768503|Cytophagia	976|Bacteroidetes	EU	peptidase S9B dipeptidylpeptidase IV domain protein	-	-	3.4.14.5	ko:K01278	ko04974,map04974	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	DPPIV_N,Peptidase_S9
k59_1731202_1	1095769.CAHF01000011_gene2143	6.96e-93	285.0	COG2133@1|root,COG2133@2|Bacteria,1MVK5@1224|Proteobacteria,2VKWZ@28216|Betaproteobacteria,473HC@75682|Oxalobacteraceae	28216|Betaproteobacteria	G	Glucose / Sorbosone dehydrogenase	sndH	-	-	-	-	-	-	-	-	-	-	-	GSDH
k59_341213_1	570967.JMLV01000001_gene2971	9.6e-27	102.0	COG1551@1|root,COG1551@2|Bacteria,1Q20H@1224|Proteobacteria,2UHK1@28211|Alphaproteobacteria,2JU54@204441|Rhodospirillales	204441|Rhodospirillales	T	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding	csrA	-	-	ko:K03563	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03019	-	-	-	CsrA
k59_786272_1	309807.SRU_1984	1.71e-45	159.0	2CHNQ@1|root,2Z7KM@2|Bacteria,4NHAA@976|Bacteroidetes,1FK2S@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_786272_2	1121904.ARBP01000028_gene1676	1.17e-06	48.9	COG0332@1|root,COG0332@2|Bacteria,4NFIN@976|Bacteroidetes,47JAR@768503|Cytophagia	976|Bacteroidetes	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
k59_619260_1	335543.Sfum_1818	4.21e-18	77.4	COG3360@1|root,COG3360@2|Bacteria,1Q2I5@1224|Proteobacteria,42VRR@68525|delta/epsilon subdivisions,2WRD2@28221|Deltaproteobacteria,2MS5T@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
k59_1675707_1	671143.DAMO_2917	4.43e-93	302.0	COG0667@1|root,COG1331@1|root,COG0667@2|Bacteria,COG1331@2|Bacteria,2NP26@2323|unclassified Bacteria	2|Bacteria	O	Protein of unknown function, DUF255	yyaL	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,GlcNAc_2-epim,Thioredox_DsbH
k59_1453644_2	545693.BMQ_0404	1.71e-05	47.0	COG1028@1|root,COG1028@2|Bacteria,1TRVE@1239|Firmicutes,4HCFY@91061|Bacilli,1ZAXT@1386|Bacillus	91061|Bacilli	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	fabL	GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576	1.3.1.104	ko:K10780	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00083	R01404,R04430,R04725,R04956,R04959,R04962,R04967,R04970	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_1231874_1	525904.Tter_0023	3.16e-06	53.9	COG0644@1|root,COG0644@2|Bacteria,2NQ4F@2323|unclassified Bacteria	2|Bacteria	C	TIGRFAM geranylgeranyl reductase	fixC	-	1.3.99.38	ko:K21401	-	-	-	-	ko00000,ko01000	-	-	-	DAO,FAD_binding_3,Trp_halogenase
k59_174629_1	572547.Amico_1372	2.67e-61	204.0	COG0064@1|root,COG0064@2|Bacteria,3TA2M@508458|Synergistetes	508458|Synergistetes	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
k59_341236_1	886293.Sinac_6682	6.19e-76	241.0	COG0422@1|root,COG0422@2|Bacteria,2IWV7@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC_Rad_SAM
k59_63478_1	1379270.AUXF01000001_gene1941	2.5e-14	80.1	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,1ZUHA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Tetratricopeptide repeat	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_12
k59_730925_1	906968.Trebr_1075	2.88e-56	192.0	COG0504@1|root,COG0504@2|Bacteria,2J5AB@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
k59_286000_1	756272.Plabr_1364	1.23e-75	241.0	COG3119@1|root,COG3119@2|Bacteria,2J24P@203682|Planctomycetes	203682|Planctomycetes	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_730929_1	1123366.TH3_14964	1.7e-35	130.0	COG2121@1|root,COG2121@2|Bacteria,1MZID@1224|Proteobacteria,2TSGQ@28211|Alphaproteobacteria,2JS37@204441|Rhodospirillales	204441|Rhodospirillales	S	protein conserved in bacteria	-	-	-	ko:K09778	-	-	-	-	ko00000	-	-	-	DUF374
k59_730929_2	1282360.ABAC460_20045	2.45e-07	52.4	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2TQMR@28211|Alphaproteobacteria,2KFS9@204458|Caulobacterales	204458|Caulobacterales	V	TIGRFAM lipid A ABC exporter family, fused ATPase and inner membrane subunits	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_1342151_1	882083.SacmaDRAFT_2019	2.09e-40	144.0	COG0685@1|root,COG0685@2|Bacteria,2I92A@201174|Actinobacteria,4DYTG@85010|Pseudonocardiales	201174|Actinobacteria	E	Methylenetetrahydrofolate reductase	-	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
k59_1342152_1	290400.Jann_1163	7.07e-23	103.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TSN5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	FAD linked oxidase domain protein	MA20_43170	-	-	-	-	-	-	-	-	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_8
k59_1008798_1	1121104.AQXH01000001_gene2028	1.21e-73	248.0	COG0841@1|root,COG0841@2|Bacteria,4NDZG@976|Bacteroidetes,1IQYT@117747|Sphingobacteriia	976|Bacteroidetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_675283_2	1521187.JPIM01000078_gene1055	5.69e-14	75.9	COG2211@1|root,COG2211@2|Bacteria,2G6B9@200795|Chloroflexi,376JP@32061|Chloroflexia	32061|Chloroflexia	G	PFAM PUCC protein	-	-	-	ko:K08226	-	-	-	-	ko00000,ko02000	2.A.1.41	-	-	PUCC
k59_1342154_1	105422.BBPM01000012_gene6989	1.24e-14	75.1	COG1211@1|root,COG1211@2|Bacteria,2GNHP@201174|Actinobacteria,2NGV5@228398|Streptacidiphilus	201174|Actinobacteria	I	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	ispD	GO:0000166,GO:0000287,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016020,GO:0016114,GO:0016740,GO:0016772,GO:0016779,GO:0019103,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0032549,GO:0032551,GO:0032553,GO:0032557,GO:0032787,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044464,GO:0046490,GO:0046872,GO:0046914,GO:0050518,GO:0051483,GO:0051484,GO:0070567,GO:0071704,GO:0071944,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901576	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
k59_1342154_2	33898.JRHJ01000069_gene7389	2.76e-22	91.7	COG1247@1|root,COG1247@2|Bacteria,2GR9D@201174|Actinobacteria	201174|Actinobacteria	M	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_1175365_1	396588.Tgr7_2066	1.45e-67	223.0	COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,1RMIQ@1236|Gammaproteobacteria,1WX1G@135613|Chromatiales	135613|Chromatiales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD-TM1,SecD_SecF,Sec_GG
k59_897762_1	1034347.CAHJ01000013_gene2415	5.64e-17	83.6	COG1414@1|root,COG1414@2|Bacteria,1TQS2@1239|Firmicutes,4HBYR@91061|Bacilli,1ZDMV@1386|Bacillus	91061|Bacilli	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
k59_1342157_1	1265507.KB899636_gene2022	1.01e-19	89.4	29X52@1|root,30IU1@2|Bacteria,1N8YP@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1509017_1	335543.Sfum_2140	1.21e-13	73.9	COG0683@1|root,COG0683@2|Bacteria,1NHBN@1224|Proteobacteria,42RYV@68525|delta/epsilon subdivisions,2WNEF@28221|Deltaproteobacteria,2MRZ5@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Amino acid amide ABC transporter substrate-binding protein, HAAT family	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_1509017_2	1056816.JAFQ01000004_gene4102	5.5e-74	226.0	COG2030@1|root,COG2030@2|Bacteria,2GN4R@201174|Actinobacteria,4G8T2@85025|Nocardiaceae	201174|Actinobacteria	I	MaoC like domain	-	-	4.2.1.56	ko:K18290	ko00660,map00660	-	R02491	RC00730	ko00000,ko00001,ko01000	-	-	-	MaoC_dehydratas
k59_174677_1	1123376.AUIU01000012_gene1625	2.66e-141	409.0	COG0050@1|root,COG0050@2|Bacteria,3J0DG@40117|Nitrospirae	40117|Nitrospirae	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	-	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
k59_452932_1	5693.XP_813083.1	4.3e-50	169.0	COG2084@1|root,KOG0409@2759|Eukaryota,3XS8U@5653|Kinetoplastida	5653|Kinetoplastida	E	2-hydroxy-3-oxopropionate reductase	-	-	1.1.1.60	ko:K00042	ko00630,ko01100,map00630,map01100	-	R01745,R01747	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
k59_1286621_1	1265505.ATUG01000001_gene4482	5.37e-85	259.0	COG1173@1|root,COG1173@2|Bacteria,1MW3R@1224|Proteobacteria,43AQ5@68525|delta/epsilon subdivisions,2X63Y@28221|Deltaproteobacteria,2MPHJ@213118|Desulfobacterales	28221|Deltaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
k59_8188_1	1043205.AFYF01000026_gene325	9.37e-15	74.3	COG2267@1|root,COG2267@2|Bacteria,2GPA8@201174|Actinobacteria,4FF8K@85021|Intrasporangiaceae	201174|Actinobacteria	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
k59_8188_2	29495.EA26_17710	2.27e-20	92.8	COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,1RMGP@1236|Gammaproteobacteria,1XSTC@135623|Vibrionales	135623|Vibrionales	C	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family	glpD	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C
k59_1675790_2	926560.KE387023_gene3233	5.4e-43	144.0	COG0662@1|root,COG0662@2|Bacteria,1WMY9@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_675328_1	862908.BMS_0068	2.11e-44	159.0	COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,42MS2@68525|delta/epsilon subdivisions,2MSPD@213481|Bdellovibrionales,2WIQ0@28221|Deltaproteobacteria	213481|Bdellovibrionales	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
k59_1120245_1	395963.Bind_2777	2.22e-34	119.0	COG0636@1|root,COG0636@2|Bacteria,1NAIE@1224|Proteobacteria,2UBRD@28211|Alphaproteobacteria,3NBI5@45404|Beijerinckiaceae	28211|Alphaproteobacteria	C	ATP synthase subunit C	-	-	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
k59_1120245_2	1207055.C100_01870	4.61e-40	139.0	COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,2U06M@28211|Alphaproteobacteria,2K3A7@204457|Sphingomonadales	204457|Sphingomonadales	C	it plays a direct role in the translocation of protons across the membrane	atpB_1	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
k59_1342204_1	1382356.JQMP01000003_gene2367	5.67e-52	178.0	COG0624@1|root,COG0624@2|Bacteria,2G63E@200795|Chloroflexi,27Y1X@189775|Thermomicrobia	189775|Thermomicrobia	E	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
k59_118902_1	1304275.C41B8_14605	2.53e-20	91.3	COG4923@1|root,COG4923@2|Bacteria,1MY1R@1224|Proteobacteria,1SQHQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Protein of unknown function (DUF429)	-	-	-	-	-	-	-	-	-	-	-	-	DUF429
k59_1286653_1	96561.Dole_1886	1.21e-37	138.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,42M2M@68525|delta/epsilon subdivisions,2WJ5H@28221|Deltaproteobacteria,2MHSU@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH,NMO
k59_1619972_1	933262.AXAM01000008_gene1935	2.63e-55	189.0	COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,42MS8@68525|delta/epsilon subdivisions,2WJB6@28221|Deltaproteobacteria,2MJ96@213118|Desulfobacterales	28221|Deltaproteobacteria	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
k59_1619975_1	992406.RIA_1879	1.84e-22	95.1	COG1960@1|root,COG1960@2|Bacteria,4NEHA@976|Bacteroidetes,1HWV4@117743|Flavobacteriia	976|Bacteroidetes	I	acyl-CoA dehydrogenase	acdA	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_1619975_2	861299.J421_3338	8.11e-25	103.0	COG1530@1|root,COG1530@2|Bacteria,1ZSZS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Ribonuclease E/G family	-	-	-	ko:K08301	-	-	-	-	ko00000,ko01000,ko03009,ko03019	-	-	-	RNase_E_G
k59_731021_1	861299.J421_0279	1.76e-39	153.0	COG0577@1|root,COG0577@2|Bacteria	861299.J421_0279|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1342222_1	111780.Sta7437_2617	2.87e-87	283.0	COG0045@1|root,COG1042@1|root,COG1670@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1670@2|Bacteria,1G2D3@1117|Cyanobacteria,3VIFN@52604|Pleurocapsales	1117|Cyanobacteria	CJ	TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain	-	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
k59_1008880_2	886293.Sinac_7277	5.21e-28	112.0	COG0694@1|root,COG0694@2|Bacteria	2|Bacteria	O	iron-sulfur cluster assembly	nfuA	-	-	ko:K07400	-	-	-	-	ko00000	-	-	-	Nfu_N,NifU
k59_1064227_1	324602.Caur_3745	3.62e-80	255.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
k59_1564635_1	1423144.Gal_00772	9.81e-64	214.0	COG0644@1|root,COG0644@2|Bacteria,1R41S@1224|Proteobacteria,2TW03@28211|Alphaproteobacteria,34G0N@302485|Phaeobacter	28211|Alphaproteobacteria	C	Tryptophan halogenase	-	-	1.14.19.9	ko:K14266	ko00404,ko01130,map00404,map01130	M00789,M00790	R09570	RC00949	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_halogenase
k59_397139_1	1120983.KB894570_gene1677	3.8e-27	108.0	COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,2TVQR@28211|Alphaproteobacteria,1JNTT@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Patatin-like phospholipase	rssA	GO:0003674,GO:0003824,GO:0016787	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
k59_731044_1	1288826.MSNKSG1_15087	1.31e-107	318.0	COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,1RRF1@1236|Gammaproteobacteria,46A3T@72275|Alteromonadaceae	1236|Gammaproteobacteria	Q	Part of the tripartite ATP-independent periplasmic (TRAP) transport system	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_508377_1	1232437.KL661959_gene3100	6.58e-06	51.6	COG3745@1|root,COG3745@2|Bacteria,1MW75@1224|Proteobacteria,42S07@68525|delta/epsilon subdivisions,2WNR0@28221|Deltaproteobacteria,2MKBT@213118|Desulfobacterales	28221|Deltaproteobacteria	U	Flp pilus assembly protein RcpC/CpaB	-	-	-	ko:K02279	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	ChapFlgA,RcpC,SAF
k59_508377_2	1292020.H483_0115390	1.1e-06	52.4	COG4961@1|root,COG4961@2|Bacteria,2IS3K@201174|Actinobacteria	201174|Actinobacteria	U	TadE-like protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
k59_453025_1	444157.Tneu_0541	1.72e-20	92.0	COG1250@1|root,arCOG00249@2157|Archaea,2XPQ7@28889|Crenarchaeota	28889|Crenarchaeota	I	3-hydroxyacyl-CoA dehydrogenase	-	-	1.1.1.35,4.2.1.17	ko:K15016	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00374,M00375	R01975,R03026	RC00117,RC00831	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
k59_453025_2	1123288.SOV_2c00250	2.33e-12	70.1	COG0477@1|root,COG2814@2|Bacteria,1TQHD@1239|Firmicutes,4H2AI@909932|Negativicutes	909932|Negativicutes	EGP	Major Facilitator	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
k59_397154_1	1345023.M467_05080	2.31e-25	100.0	COG0563@1|root,COG0563@2|Bacteria,1V7AW@1239|Firmicutes,4HH8A@91061|Bacilli	91061|Bacilli	F	topology modulation protein	flaR	-	-	-	-	-	-	-	-	-	-	-	AAA_18,ABC_tran
k59_397154_2	981384.AEYW01000028_gene4265	3.22e-11	63.9	COG2267@1|root,COG2267@2|Bacteria,1RG43@1224|Proteobacteria,2U6MB@28211|Alphaproteobacteria,4NCZ2@97050|Ruegeria	28211|Alphaproteobacteria	I	Ndr family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
k59_1675866_1	647113.Metok_0663	5.68e-36	131.0	COG0543@1|root,arCOG02199@2157|Archaea,2XSY9@28890|Euryarchaeota,23QKQ@183939|Methanococci	183939|Methanococci	C	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(	pyrK	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind,NAD_binding_1
k59_675400_1	1408424.JHYI01000015_gene4797	1.27e-15	82.4	COG1216@1|root,COG1216@2|Bacteria,1VATJ@1239|Firmicutes,4HCW0@91061|Bacilli,1ZFI5@1386|Bacillus	91061|Bacilli	S	COG0463 Glycosyltransferases involved in cell wall biogenesis	epsJ	GO:0003674,GO:0003824,GO:0016740,GO:0016757	-	ko:K19425,ko:K19427	-	-	-	-	ko00000,ko01000,ko01003	-	GT2	-	Glycos_transf_2
k59_1286712_1	891968.Anamo_1078	1.07e-61	201.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	4.1.1.55	ko:K04102	ko00624,ko01100,ko01120,map00624,map01100,map01120	M00623	R01635,R05375	RC00390	ko00000,ko00001,ko00002,ko01000	-	-	-	NMT1
k59_1621132_1	102129.Lepto7375DRAFT_0257	1.01e-61	205.0	COG0367@1|root,COG0367@2|Bacteria,1FZZS@1117|Cyanobacteria,1HC0F@1150|Oscillatoriales	1117|Cyanobacteria	E	Asparagine synthase	asnB	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
k59_1510303_1	1380386.JIAW01000006_gene1201	2.75e-38	143.0	COG2114@1|root,COG3437@1|root,COG2114@2|Bacteria,COG3437@2|Bacteria,2GNPX@201174|Actinobacteria,23FH5@1762|Mycobacteriaceae	201174|Actinobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	osaB	-	-	-	-	-	-	-	-	-	-	-	Response_reg
k59_454232_1	316067.Geob_1777	1.39e-87	266.0	COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,42MEE@68525|delta/epsilon subdivisions,2WJYV@28221|Deltaproteobacteria,43T22@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
k59_1287874_2	1045855.DSC_05030	7.8e-05	47.8	COG0438@1|root,COG1216@1|root,COG0438@2|Bacteria,COG1216@2|Bacteria,1MVIM@1224|Proteobacteria,1RPB8@1236|Gammaproteobacteria,1X3GZ@135614|Xanthomonadales	135614|Xanthomonadales	M	Glycosyl transferase	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glyco_trans_1_4,Glycos_transf_2
k59_1121563_1	518766.Rmar_2417	2.1e-105	315.0	COG3191@1|root,COG3191@2|Bacteria,4NGDT@976|Bacteroidetes,1FJRD@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	EQ	Peptidase family S58	-	-	3.4.11.19	ko:K01266	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S58
k59_954258_1	28072.Nos7524_3266	4.95e-45	159.0	COG5433@1|root,COG5433@2|Bacteria,1G0VN@1117|Cyanobacteria,1HJR6@1161|Nostocales	1117|Cyanobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
k59_1176724_1	1037409.BJ6T_66550	0.000145	49.7	COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TTJ0@28211|Alphaproteobacteria,3JS5D@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,PAS_7,dCache_1
k59_1343395_1	999141.GME_13345	7.99e-69	214.0	COG0088@1|root,COG0088@2|Bacteria,1MXPF@1224|Proteobacteria,1RNNK@1236|Gammaproteobacteria,1XH61@135619|Oceanospirillales	135619|Oceanospirillales	J	Forms part of the polypeptide exit tunnel	rplD	-	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
k59_1121568_1	639030.JHVA01000001_gene401	6.49e-85	259.0	COG1961@1|root,COG1961@2|Bacteria	2|Bacteria	L	recombinase activity	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
k59_1343398_1	1232683.ADIMK_3174	1.99e-39	141.0	COG2853@1|root,COG2853@2|Bacteria,1MVX0@1224|Proteobacteria,1RNPS@1236|Gammaproteobacteria,466E2@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	Surface lipoprotein	vacJ	-	-	ko:K04754	-	-	-	-	ko00000	-	-	-	MlaA
k59_787752_1	1172188.KB911821_gene2078	3.98e-08	62.0	COG0642@1|root,COG2205@2|Bacteria,2I2M2@201174|Actinobacteria,4FFYD@85021|Intrasporangiaceae	201174|Actinobacteria	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365,GAF_2,HAMP,HATPase_c,HisKA,Response_reg
k59_1287892_1	1380394.JADL01000011_gene3790	1.68e-49	169.0	COG0657@1|root,COG0657@2|Bacteria,1PBWF@1224|Proteobacteria,2U6QV@28211|Alphaproteobacteria,2JX9A@204441|Rhodospirillales	204441|Rhodospirillales	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
k59_1577152_1	999550.KI421507_gene229	7.6e-09	54.7	COG1047@1|root,COG1047@2|Bacteria,1RD35@1224|Proteobacteria,2U79E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Peptidyl-prolyl cis-trans	slyD	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	FKBP_C
k59_1577152_2	935836.JAEL01000004_gene2507	3.08e-16	82.8	COG1960@1|root,COG1960@2|Bacteria,1TQC8@1239|Firmicutes,4HC6Y@91061|Bacilli,1ZCXT@1386|Bacillus	91061|Bacilli	I	Acyl-CoA dehydrogenase, middle domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M
k59_631287_1	1134413.ANNK01000089_gene350	2.65e-61	200.0	COG1063@1|root,COG1063@2|Bacteria,1TPWP@1239|Firmicutes,4IPQ3@91061|Bacilli	91061|Bacilli	E	Dehydrogenase	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_1076755_1	861299.J421_4087	5.93e-30	119.0	COG3408@1|root,COG3459@1|root,COG3408@2|Bacteria,COG3459@2|Bacteria	2|Bacteria	G	carbohydrate binding	cbpA	-	2.4.1.333	ko:K21298	-	-	-	-	ko00000,ko01000	-	GH94	-	BNR_2,F5_F8_type_C,Glyco_hydro_36,Glyco_transf_36,Trehalase
k59_353514_1	1283299.AUKG01000004_gene1220	1.66e-37	145.0	COG1252@1|root,COG1252@2|Bacteria,2GJFE@201174|Actinobacteria,4CPW0@84995|Rubrobacteria	84995|Rubrobacteria	C	FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_853528_1	1278073.MYSTI_07741	5.11e-28	119.0	COG0577@1|root,COG0577@2|Bacteria,1NREW@1224|Proteobacteria	1224|Proteobacteria	V	COG0577 ABC-type antimicrobial peptide transport system permease component	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_1688486_2	1117379.BABA_03824	8.44e-78	246.0	COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,4HBED@91061|Bacilli,1ZKX1@1386|Bacillus	91061|Bacilli	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_298624_1	1132509.C447_16004	6.38e-15	74.7	COG2050@1|root,arCOG00777@2157|Archaea,2XXD0@28890|Euryarchaeota,23VME@183963|Halobacteria	183963|Halobacteria	Q	protein, possibly involved in aromatic compounds catabolism	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
k59_466190_1	1283299.AUKG01000004_gene1167	2.08e-27	108.0	COG0560@1|root,COG0560@2|Bacteria,2GKRQ@201174|Actinobacteria	201174|Actinobacteria	E	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
k59_20754_1	1173021.ALWA01000019_gene410	3.62e-55	179.0	COG0107@1|root,COG0107@2|Bacteria,1G18S@1117|Cyanobacteria	1117|Cyanobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
k59_688353_1	511051.CSE_08740	4.7e-37	131.0	COG0693@1|root,COG0693@2|Bacteria	2|Bacteria	S	protein deglycation	pfpI	-	3.5.1.124	ko:K05520	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DJ-1_PfpI
k59_853540_1	1151117.AJLF01000001_gene1469	1.33e-12	72.4	COG0043@1|root,arCOG01671@2157|Archaea,2XUDW@28890|Euryarchaeota,242S6@183968|Thermococci	183968|Thermococci	H	3-octaprenyl-4-hydroxybenzoate carboxy-lyase	-	-	-	-	-	-	-	-	-	-	-	-	UbiD
k59_1299262_1	324057.Pjdr2_0523	1.82e-54	192.0	COG2303@1|root,COG2303@2|Bacteria,1TSGS@1239|Firmicutes,4HE6B@91061|Bacilli,26XXV@186822|Paenibacillaceae	91061|Bacilli	E	GMC oxidoreductase	-	-	1.1.99.3	ko:K06151	ko00030,ko01100,ko01120,map00030,map01100,map01120	-	R01741	RC00084	ko00000,ko00001,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N,Gluconate_2-dh3
k59_242958_1	82654.Pse7367_1577	2.58e-51	182.0	COG0531@1|root,COG0531@2|Bacteria,1G248@1117|Cyanobacteria,1H8SD@1150|Oscillatoriales	1117|Cyanobacteria	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease,SLC12
k59_1299270_1	1297742.A176_06444	8.36e-38	147.0	COG0577@1|root,COG0577@2|Bacteria,1NREW@1224|Proteobacteria,433ZM@68525|delta/epsilon subdivisions,2X48T@28221|Deltaproteobacteria,2YYI5@29|Myxococcales	28221|Deltaproteobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_688372_1	1379270.AUXF01000004_gene2921	2.65e-81	256.0	COG0514@1|root,COG0514@2|Bacteria,1ZUBS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	RecQ zinc-binding	-	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,Helicase_C,RecQ_Zn_bind
k59_1299277_1	1122176.KB903539_gene1307	4.59e-12	68.6	COG2834@1|root,COG2834@2|Bacteria,4NHV3@976|Bacteroidetes,1IZ7F@117747|Sphingobacteriia	976|Bacteroidetes	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4292,LolA_like
k59_187059_1	370438.PTH_0241	2.82e-57	188.0	COG2046@1|root,COG2046@2|Bacteria,1TR4C@1239|Firmicutes,249ZJ@186801|Clostridia,26026@186807|Peptococcaceae	186801|Clostridia	H	Belongs to the sulfate adenylyltransferase family	sat	-	2.7.7.4	ko:K00958	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-sulfurylase,PUA_2
k59_688384_1	1150864.MILUP08_46615	3.73e-11	67.0	COG1131@1|root,COG1131@2|Bacteria,2GN8P@201174|Actinobacteria,4DAX5@85008|Micromonosporales	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_688384_2	1278073.MYSTI_04687	4.81e-21	90.5	COG2386@1|root,COG2386@2|Bacteria,1QF23@1224|Proteobacteria,42RAM@68525|delta/epsilon subdivisions,2WMS1@28221|Deltaproteobacteria,2YVDV@29|Myxococcales	28221|Deltaproteobacteria	U	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	ccmB	-	-	ko:K02194	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	CcmB
k59_743610_1	765420.OSCT_2127	6.64e-14	76.6	2CVPW@1|root,32SXZ@2|Bacteria,2G7DV@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_853581_1	1151127.KB906325_gene4672	4.27e-05	51.2	COG2931@1|root,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_2,CHU_C,DUF4347,HemolysinCabind
k59_1076824_1	379066.GAU_2475	2.4e-102	311.0	COG0346@1|root,COG0346@2|Bacteria,1ZTUT@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	ko:K15975	-	-	-	-	ko00000	-	-	-	Glyoxalase
k59_1466253_1	1123258.AQXZ01000019_gene2939	1.2e-05	44.3	2EN3K@1|root,33FRP@2|Bacteria,2H7T0@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1466253_2	314278.NB231_15718	7.15e-36	124.0	COG2963@1|root,COG2963@2|Bacteria,1N8Y3@1224|Proteobacteria	1224|Proteobacteria	L	PFAM transposase IS3 IS911 family protein	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_1521519_1	215803.DB30_6358	3.9e-28	110.0	arCOG09511@1|root,2Z9DH@2|Bacteria,1MXRV@1224|Proteobacteria,42N0Y@68525|delta/epsilon subdivisions,2WK5S@28221|Deltaproteobacteria,2YY46@29|Myxococcales	28221|Deltaproteobacteria	S	FRG	-	-	-	-	-	-	-	-	-	-	-	-	FRG
k59_409894_1	1454010.JEOE01000001_gene675	4.18e-19	91.3	COG0815@1|root,COG0815@2|Bacteria,2GJ9F@201174|Actinobacteria,4F0G7@85016|Cellulomonadaceae	201174|Actinobacteria	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
k59_1410642_1	497964.CfE428DRAFT_3863	1.73e-65	218.0	COG3119@1|root,COG3119@2|Bacteria,46UNA@74201|Verrucomicrobia	74201|Verrucomicrobia	P	PFAM sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_911218_1	1193181.BN10_120037	1e-09	63.9	COG1752@1|root,COG1752@2|Bacteria,2GNBM@201174|Actinobacteria,4FETQ@85021|Intrasporangiaceae	201174|Actinobacteria	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
k59_20827_1	526222.Desal_3820	6.6e-49	174.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,42M5C@68525|delta/epsilon subdivisions,2WJ54@28221|Deltaproteobacteria,2M8IF@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	PFAM Lytic transglycosylase catalytic	-	-	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	LysM,SLT
k59_1466273_1	105420.BBPO01000029_gene6805	3.42e-41	147.0	COG0524@1|root,COG0524@2|Bacteria,2GKBG@201174|Actinobacteria,2NG52@228398|Streptacidiphilus	201174|Actinobacteria	G	pfkB family carbohydrate kinase	adoK	GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004001,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005975,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019200,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032550,GO:0032552,GO:0032553,GO:0032554,GO:0032555,GO:0032559,GO:0032560,GO:0032561,GO:0032567,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046390,GO:0046483,GO:0046835,GO:0046872,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.1.20	ko:K00856	ko00230,ko01100,map00230,map01100	-	R00185	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
k59_409908_1	1379698.RBG1_1C00001G0109	8.39e-38	137.0	COG1108@1|root,COG1108@2|Bacteria,2NQ6F@2323|unclassified Bacteria	2|Bacteria	U	ABC 3 transport family	znuB	-	-	ko:K02075,ko:K09816	ko02010,map02010	M00242,M00244	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15,3.A.1.15.3,3.A.1.15.5	-	-	ABC-3
k59_799193_1	1123325.JHUV01000013_gene1625	5.59e-33	131.0	COG0417@1|root,COG0417@2|Bacteria	2|Bacteria	L	DNA replication proofreading	polB	-	2.7.7.7	ko:K02336,ko:K06877	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	CarbopepD_reg_2,DNA_pol_B,DNA_pol_B_exo1,RNase_H_2
k59_1299323_2	671143.DAMO_0140	2.96e-33	115.0	COG1278@1|root,COG1278@2|Bacteria,2NPXP@2323|unclassified Bacteria	2|Bacteria	K	'Cold-shock' DNA-binding domain	cspA	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
k59_911241_1	1236542.BALM01000004_gene2456	1.4e-05	50.1	COG0125@1|root,COG0125@2|Bacteria,1MV9C@1224|Proteobacteria,1S26C@1236|Gammaproteobacteria,2Q8K2@267890|Shewanellaceae	1236|Gammaproteobacteria	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iECABU_c1320.ECABU_c13120,ic_1306.c1370	Thymidylate_kin
k59_1133224_1	1121937.AUHJ01000013_gene866	2.45e-108	325.0	COG0560@1|root,COG0560@2|Bacteria,1MWA3@1224|Proteobacteria,1RNJE@1236|Gammaproteobacteria,4647E@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	phosphoserine phosphatase	serB	GO:0000287,GO:0001505,GO:0003674,GO:0003824,GO:0004647,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006563,GO:0006564,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0017144,GO:0019752,GO:0042133,GO:0042136,GO:0042578,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046872,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.1.3.3	ko:K01079	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R00582	RC00017	ko00000,ko00001,ko00002,ko01000,ko01009	-	-	iE2348C_1286.E2348C_4686,iEC042_1314.EC042_4885,iECO26_1355.ECO26_5594,iECSF_1327.ECSF_4321,iECUMN_1333.ECUMN_5012,iETEC_1333.ETEC_4743,iPC815.YPO0442,iUMNK88_1353.UMNK88_5307	ACT_6,HAD,Hydrolase
k59_1299353_1	1451261.AS96_09055	4.5e-13	76.6	COG1409@1|root,COG3420@1|root,COG1409@2|Bacteria,COG3420@2|Bacteria,2I9HA@201174|Actinobacteria,4FMZU@85023|Microbacteriaceae	201174|Actinobacteria	P	Periplasmic copper-binding protein (NosD)	wcoB	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,DUF1565
k59_576158_1	330084.JNYZ01000005_gene903	1.95e-40	149.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,4DX8B@85010|Pseudonocardiales	201174|Actinobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
k59_409947_1	204669.Acid345_1052	1.31e-20	97.1	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,3Y2HR@57723|Acidobacteria,2JI02@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Tetratricopeptide repeats	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_11,TPR_16,TPR_2,Trans_reg_C
k59_799232_1	1122132.AQYH01000018_gene1145	1.35e-29	110.0	COG3184@1|root,COG3184@2|Bacteria,1NGBK@1224|Proteobacteria,2UC5I@28211|Alphaproteobacteria,4BBKS@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2059)	-	-	-	ko:K09924	-	-	-	-	ko00000	-	-	-	DUF2059
k59_799232_2	1040982.AXAL01000025_gene6753	4.07e-20	87.4	COG0120@1|root,COG0120@2|Bacteria,1MVGR@1224|Proteobacteria,2TU68@28211|Alphaproteobacteria,43HG1@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate	rpiA	-	5.3.1.6	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056	RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	Rib_5-P_isom_A
k59_521213_1	1123366.TH3_11750	1.97e-21	86.7	COG1551@1|root,COG1551@2|Bacteria,1Q20H@1224|Proteobacteria,2UHK1@28211|Alphaproteobacteria,2JU54@204441|Rhodospirillales	204441|Rhodospirillales	T	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding	csrA	-	-	ko:K03563	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03019	-	-	-	CsrA
k59_521213_2	1380394.JADL01000014_gene231	1.04e-13	67.8	COG1815@1|root,COG1815@2|Bacteria,1N1G1@1224|Proteobacteria,2UCJ4@28211|Alphaproteobacteria,2JTYT@204441|Rhodospirillales	204441|Rhodospirillales	N	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body	flgB	-	-	ko:K02387	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod
k59_1355202_1	1191523.MROS_1497	9.58e-41	150.0	COG0612@1|root,COG0612@2|Bacteria	2|Bacteria	L	Peptidase, M16	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_853687_1	1298920.KI911353_gene3100	1.8e-85	273.0	COG1123@1|root,COG4172@2|Bacteria,1UZK8@1239|Firmicutes,2511Z@186801|Clostridia,21YHK@1506553|Lachnoclostridium	186801|Clostridia	P	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_1632103_1	644107.SL1157_0992	2.72e-54	180.0	COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,1PBHA@1224|Proteobacteria,2TRQF@28211|Alphaproteobacteria,4NCIX@97050|Ruegeria	28211|Alphaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,rve,rve_3
k59_1632103_2	1231190.NA8A_22031	1.5e-61	191.0	COG2963@1|root,COG2963@2|Bacteria,1RHKX@1224|Proteobacteria,2U9TV@28211|Alphaproteobacteria,43KIH@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
k59_853692_1	1299327.I546_3492	2.44e-54	189.0	COG0111@1|root,COG0235@1|root,COG0111@2|Bacteria,COG0235@2|Bacteria,2GIZV@201174|Actinobacteria,23EW1@1762|Mycobacteriaceae	201174|Actinobacteria	EGH	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain	-	-	1.1.1.399,1.1.1.95,2.7.1.189	ko:K00058,ko:K11216	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,ko02024,map00260,map00680,map01100,map01120,map01130,map01200,map01230,map02024	M00020	R01513,R11183	RC00002,RC00017,RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,Aldolase_II,SCP2
k59_1188208_1	1463858.JOHR01000014_gene5330	6.07e-12	70.1	COG1893@1|root,COG1893@2|Bacteria	2|Bacteria	H	2-dehydropantoate 2-reductase activity	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA
k59_300096_1	196162.Noca_2335	1.04e-51	166.0	COG0251@1|root,COG0251@2|Bacteria,2IIB2@201174|Actinobacteria,4DSSJ@85009|Propionibacteriales	201174|Actinobacteria	J	Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
k59_1467755_1	1120972.AUMH01000001_gene1161	6.25e-23	96.7	COG0407@1|root,COG0407@2|Bacteria,1TR8Q@1239|Firmicutes,4HAXT@91061|Bacilli	91061|Bacilli	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
k59_1411994_1	1265313.HRUBRA_00224	1.41e-79	259.0	28IUR@1|root,2Z8TE@2|Bacteria,1NW7C@1224|Proteobacteria,1RP4W@1236|Gammaproteobacteria,1J6EN@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_577547_1	1306947.ARQD01000001_gene921	6.38e-42	152.0	COG1181@1|root,COG1181@2|Bacteria	2|Bacteria	F	Belongs to the D-alanine--D-alanine ligase family	-	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	ATP-grasp,ATP-grasp_4,CPSase_L_D2
k59_1246980_1	593105.S7A_03170	1.26e-05	47.8	COG0642@1|root,COG2205@2|Bacteria,1MUZQ@1224|Proteobacteria,1RMZT@1236|Gammaproteobacteria,3VZZ3@53335|Pantoea	1236|Gammaproteobacteria	T	Histidine kinase	kdpD	GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006970,GO:0007154,GO:0007165,GO:0008134,GO:0008150,GO:0008152,GO:0009593,GO:0009605,GO:0009628,GO:0009651,GO:0009987,GO:0009991,GO:0016020,GO:0016021,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0016787,GO:0016788,GO:0016791,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0031224,GO:0031226,GO:0031668,GO:0033554,GO:0035556,GO:0036211,GO:0042221,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051606,GO:0051716,GO:0065007,GO:0071214,GO:0071470,GO:0071472,GO:0071496,GO:0071704,GO:0071944,GO:0104004,GO:0140096,GO:1901564	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,GAF_3,HATPase_c,HisKA,KdpD,Usp
k59_1246980_2	83406.HDN1F_31650	1.46e-78	249.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1J4Q2@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	fleR	-	-	ko:K10943	ko02020,ko05111,map02020,map05111	M00515	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1189591_2	1203190.CAJP01000018_gene889	1.53e-06	48.1	COG3311@1|root,COG3311@2|Bacteria,2GQGV@201174|Actinobacteria,22P4W@1653|Corynebacteriaceae	201174|Actinobacteria	K	DNA binding domain, excisionase family	xis	-	-	-	-	-	-	-	-	-	-	-	HTH_17
k59_1189591_3	465515.Mlut_08330	7.96e-06	46.2	COG2127@1|root,COG2127@2|Bacteria,2IQ3Z@201174|Actinobacteria,1W9U2@1268|Micrococcaceae	201174|Actinobacteria	S	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation	clpS	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
k59_411311_1	352165.HMPREF7215_0234	3.11e-45	165.0	COG0751@1|root,COG0751@2|Bacteria,3T9US@508458|Synergistetes	508458|Synergistetes	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
k59_467686_1	379066.GAU_2747	2.42e-103	317.0	COG0520@1|root,COG0520@2|Bacteria,1ZT1P@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
k59_577566_1	666509.RCA23_c23340	4.7e-39	139.0	COG1879@1|root,COG1879@2|Bacteria,1MUAT@1224|Proteobacteria,2TQWT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	ABC transporter	-	-	-	ko:K10559	ko02010,map02010	M00220	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.9	-	-	Peripla_BP_4
k59_577566_2	298655.KI912266_gene2348	6.97e-08	53.5	COG1028@1|root,COG3347@1|root,COG1028@2|Bacteria,COG3347@2|Bacteria,2GNEI@201174|Actinobacteria	201174|Actinobacteria	IQ	Rhamnulose-1-phosphate aldolase alcohol dehydrogenase	srlD	-	1.1.1.140	ko:K00068	ko00051,map00051	-	R05607	RC00085	ko00000,ko00001,ko01000	-	-	-	Aldolase_II,adh_short,adh_short_C2
k59_632682_1	1449350.OCH239_20230	6.21e-82	254.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TSGZ@28211|Alphaproteobacteria,4KMUV@93682|Roseivivax	28211|Alphaproteobacteria	L	transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_300138_1	861299.J421_1009	1.83e-46	153.0	COG1846@1|root,COG1846@2|Bacteria,1ZU3J@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_34
k59_188570_1	1396141.BATP01000032_gene4356	3.23e-41	154.0	COG0514@1|root,COG0514@2|Bacteria,46S7V@74201|Verrucomicrobia,2IWN0@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	RQC	-	-	-	-	-	-	-	-	-	-	-	-	DEAD,HRDC,Helicase_C,RQC,RecQ_Zn_bind
k59_813544_1	1218074.BAXZ01000016_gene3384	2.4e-70	236.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,2VM0G@28216|Betaproteobacteria,1K22G@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.10.3.10,1.9.3.1	ko:K02274,ko:K02298,ko:K15408	ko00190,ko01100,map00190,map01100	M00155,M00417	R00081,R11335	RC00016,RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.5,3.D.4.6	-	-	COX1,COX3
k59_1148101_1	926569.ANT_26050	6.42e-62	196.0	COG5433@1|root,COG5433@2|Bacteria,2G91M@200795|Chloroflexi	200795|Chloroflexi	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
k59_1038236_1	1219035.NT2_06_02810	2.38e-131	383.0	COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,2TR04@28211|Alphaproteobacteria,2K00W@204457|Sphingomonadales	204457|Sphingomonadales	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
k59_1148106_2	1424334.W822_12875	1.66e-15	76.3	COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,2VHR2@28216|Betaproteobacteria,3T26D@506|Alcaligenaceae	28216|Betaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	rpoE	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_590497_1	1348657.M622_06775	4.84e-17	86.3	COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,2VHCS@28216|Betaproteobacteria,2KUNR@206389|Rhodocyclales	206389|Rhodocyclales	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	-	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP
k59_200708_1	1379270.AUXF01000003_gene3750	4.21e-43	159.0	COG1629@1|root,COG4219@1|root,COG1629@2|Bacteria,COG4219@2|Bacteria,1ZUHU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KPT	BlaR1 peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M56,Plug
k59_482303_1	671143.DAMO_2164	1.15e-70	219.0	COG0120@1|root,COG0120@2|Bacteria,2NPMQ@2323|unclassified Bacteria	2|Bacteria	G	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate	rpiA	GO:0003674,GO:0003824,GO:0004751,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006014,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009987,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564	2.7.1.12,2.7.1.15,5.3.1.6	ko:K00851,ko:K00852,ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01051,R01056,R01737,R02750	RC00002,RC00017,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	Rib_5-P_isom_A
k59_645221_1	596151.DesfrDRAFT_1012	1.33e-50	181.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,43CAN@68525|delta/epsilon subdivisions,2X7M5@28221|Deltaproteobacteria,2M855@213115|Desulfovibrionales	28221|Deltaproteobacteria	KT	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains	-	-	-	ko:K21405	-	-	-	-	ko00000,ko03000	-	-	-	GAF,HTH_8,PAS,PAS_8,Sigma54_activat
k59_1704824_2	204773.HEAR0405	2.31e-20	88.6	COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,2VHEP@28216|Betaproteobacteria,472FK@75682|Oxalobacteraceae	28216|Betaproteobacteria	F	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	-	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
k59_1757154_1	1205680.CAKO01000035_gene210	5.6e-90	279.0	COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2TQKQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate	-	-	1.1.99.1	ko:K00108	ko00260,ko01100,map00260,map01100	M00555	R01025	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
k59_368378_2	1379270.AUXF01000003_gene3854	4.35e-62	209.0	COG0363@1|root,COG2120@1|root,COG0363@2|Bacteria,COG2120@2|Bacteria,1ZSQV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase	-	-	3.5.99.6	ko:K02564	ko00520,ko01100,map00520,map01100	-	R00765	RC00163	ko00000,ko00001,ko01000	-	-	-	Glucosamine_iso,PIG-L
k59_590517_1	1267005.KB911261_gene2191	5.04e-69	217.0	COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,2TTKG@28211|Alphaproteobacteria,3N6V5@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Two component transcriptional regulator, winged helix family	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_1038266_1	663952.SDD27957_02155	2.1e-18	83.6	COG0517@1|root,COG0517@2|Bacteria,1V4CD@1239|Firmicutes,4HGX4@91061|Bacilli,1MA0M@119603|Streptococcus dysgalactiae group	91061|Bacilli	S	Domain in cystathionine beta-synthase and other proteins.	XK27_04065	-	-	ko:K04767	-	-	-	-	ko00000	-	-	-	ACT,CBS
k59_1091994_1	1267534.KB906754_gene3767	3.68e-11	68.9	COG0277@1|root,COG0277@2|Bacteria	2|Bacteria	C	FAD linked oxidase domain protein	glcE	-	-	ko:K11472	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_34807_1	383372.Rcas_3859	1.86e-118	347.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5,DDE_Tnp_1
k59_981962_1	990285.RGCCGE502_03697	2.77e-28	119.0	COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2TVYB@28211|Alphaproteobacteria,4B9QH@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Histidine kinase	pdhS	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_8,PAS_9
k59_1315440_1	1121912.AUHD01000004_gene2072	1.7e-63	206.0	COG2755@1|root,COG2755@2|Bacteria,4NHBT@976|Bacteroidetes,1HYY1@117743|Flavobacteriia	976|Bacteroidetes	E	COG2755 Lysophospholipase L1 and related	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
k59_645250_1	384765.SIAM614_06158	1.17e-16	79.3	COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,2TRD8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
k59_645250_2	1528106.JRJE01000005_gene1334	2.51e-46	162.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,2TQP1@28211|Alphaproteobacteria,2JPCV@204441|Rhodospirillales	204441|Rhodospirillales	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	ctaD	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_1369975_1	1173264.KI913949_gene3228	2.44e-06	52.4	COG3119@1|root,COG3119@2|Bacteria,1G35S@1117|Cyanobacteria	1117|Cyanobacteria	P	Arylsulfatase a	-	-	-	ko:K01138	-	-	-	-	ko00000,ko01000	-	-	-	Sulfatase,Sulfatase_C
k59_1369980_1	2340.JV46_09560	4.83e-40	147.0	COG0475@1|root,COG0475@2|Bacteria,1RB9F@1224|Proteobacteria,1S398@1236|Gammaproteobacteria,1J6EW@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	P COG0025 NhaP-type Na H and K H antiporters	-	-	-	ko:K11747	-	-	-	-	ko00000,ko02000	2.A.37.1.2	-	-	Na_H_Exchanger
k59_1757184_1	1150626.PHAMO_210251	1.22e-76	234.0	COG3820@1|root,COG3820@2|Bacteria,1MVR2@1224|Proteobacteria,2TT8Z@28211|Alphaproteobacteria,2JRSY@204441|Rhodospirillales	204441|Rhodospirillales	S	protein conserved in bacteria	-	-	-	ko:K09987	-	-	-	-	ko00000	-	-	-	DUF1013
k59_868254_1	926569.ANT_07730	6.44e-54	185.0	COG1361@1|root,COG1361@2|Bacteria	2|Bacteria	M	extracellular matrix structural constituent	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,DUF4114,DUF4157
k59_200765_1	926569.ANT_04980	5.87e-40	135.0	COG3677@1|root,COG3677@2|Bacteria,2G9MB@200795|Chloroflexi	200795|Chloroflexi	L	Putative ATPase subunit of terminase (gpP-like)	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23
k59_200765_2	926569.ANT_30020	2.83e-55	174.0	COG1662@1|root,COG1662@2|Bacteria	2|Bacteria	L	PFAM IS1 transposase	-	-	-	ko:K07480	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS1
k59_482361_1	469371.Tbis_0015	1.57e-33	130.0	COG1055@1|root,COG1055@2|Bacteria,2GMQJ@201174|Actinobacteria,4DZHF@85010|Pseudonocardiales	201174|Actinobacteria	P	Bacterial Na+/H+ antiporter B (NhaB)	-	-	-	ko:K03893	-	-	-	-	ko00000,ko02000	2.A.45.1,3.A.4.1	-	-	ArsB,CitMHS
k59_1757189_1	1487953.JMKF01000058_gene5010	3.38e-19	94.0	COG1165@1|root,COG1165@2|Bacteria,1G1FW@1117|Cyanobacteria,1H8TT@1150|Oscillatoriales	1117|Cyanobacteria	H	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)	menD	-	2.2.1.9	ko:K02551	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R08165	RC02186	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M_2,TPP_enzyme_N
k59_535651_1	1157635.KB892003_gene3660	9.21e-09	61.2	COG3420@1|root,COG3420@2|Bacteria,2GNYS@201174|Actinobacteria	201174|Actinobacteria	P	Periplasmic copper-binding protein (NosD)	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
k59_1425077_1	633.DJ40_2574	1.61e-33	129.0	COG1929@1|root,COG1929@2|Bacteria,1MVG9@1224|Proteobacteria,1RMC6@1236|Gammaproteobacteria,41EGY@629|Yersinia	1236|Gammaproteobacteria	G	Belongs to the glycerate kinase type-1 family	garK	-	2.7.1.165	ko:K00865	ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130	-	R08572	RC00002,RC00428	ko00000,ko00001,ko01000	-	-	-	Gly_kinase
k59_1315485_1	234267.Acid_6005	3.39e-43	150.0	COG0596@1|root,COG0596@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on ester bonds	-	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1,Abhydrolase_6
k59_1370017_2	395964.KE386496_gene1149	3.36e-24	101.0	COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,2TRI9@28211|Alphaproteobacteria,3N9ZN@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	MMPL family	acrB	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL,cNMP_binding
k59_482392_1	497321.C664_12965	7.62e-86	261.0	COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,2VIIY@28216|Betaproteobacteria,2KVGB@206389|Rhodocyclales	206389|Rhodocyclales	F	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	-	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
k59_145630_1	311424.DhcVS_570	2.22e-55	185.0	COG1181@1|root,COG1181@2|Bacteria,2G5RS@200795|Chloroflexi,34CTK@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Belongs to the D-alanine--D-alanine ligase family	-	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
k59_1148209_1	926560.KE387023_gene3344	1.81e-13	71.2	2DBC8@1|root,2Z8C9@2|Bacteria,1WKX1@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1148209_2	926550.CLDAP_20410	9.16e-13	69.3	COG2124@1|root,COG2124@2|Bacteria,2G623@200795|Chloroflexi	2|Bacteria	C	PFAM Cytochrome P450	cyp139A3	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006629,GO:0008150,GO:0008152,GO:0008202,GO:0016125,GO:0016491,GO:0030312,GO:0044238,GO:0044464,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901615	-	-	-	-	-	-	-	-	-	-	p450
k59_1315494_1	637905.SVI_3040	3e-38	147.0	COG0793@1|root,COG0793@2|Bacteria,1R5Y0@1224|Proteobacteria,1S121@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Peptidase family S41	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S41
k59_1535949_1	1423321.AS29_14580	7.78e-13	68.6	COG3910@1|root,COG3910@2|Bacteria,1TSWP@1239|Firmicutes,4HBQT@91061|Bacilli,1ZCVC@1386|Bacillus	91061|Bacilli	S	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_15,AAA_21,AAA_23
k59_145640_1	13035.Dacsa_0517	6.2e-09	58.2	COG0697@1|root,COG0697@2|Bacteria,1G24W@1117|Cyanobacteria	1117|Cyanobacteria	EG	PFAM EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_1704921_1	234267.Acid_4442	1.96e-08	61.2	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_757975_1	1121033.AUCF01000046_gene544	1.14e-48	160.0	COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,2TTX4@28211|Alphaproteobacteria,2JSB3@204441|Rhodospirillales	204441|Rhodospirillales	K	Belongs to the UPF0301 (AlgH) family	-	-	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
k59_757975_2	1382303.JPOM01000001_gene2045	6.91e-12	64.3	COG1670@1|root,COG1670@2|Bacteria,1MVG4@1224|Proteobacteria,2TUIK@28211|Alphaproteobacteria,2KGBF@204458|Caulobacterales	204458|Caulobacterales	J	Acetyltransferase (GNAT) domain	-	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
k59_1645635_1	562970.Btus_1769	1.15e-54	186.0	COG1160@1|root,COG1160@2|Bacteria,1TPNM@1239|Firmicutes,4HAJ6@91061|Bacilli,278SV@186823|Alicyclobacillaceae	91061|Bacilli	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
k59_868333_1	631454.N177_3075	1.29e-71	225.0	COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,2TRYS@28211|Alphaproteobacteria,1JNH3@119043|Rhodobiaceae	28211|Alphaproteobacteria	I	PFAM Enoyl-CoA hydratase isomerase	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
k59_200824_1	395961.Cyan7425_4614	4.16e-41	144.0	COG0400@1|root,COG0400@2|Bacteria,1G3RX@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM phospholipase Carboxylesterase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_2,Esterase
k59_1645642_1	349161.Dred_2097	6.13e-17	87.0	COG0857@1|root,COG1227@1|root,COG0857@2|Bacteria,COG1227@2|Bacteria,1TPH6@1239|Firmicutes,248RQ@186801|Clostridia,260EW@186807|Peptococcaceae	186801|Clostridia	C	DHHA2 domain	ppaC	-	3.6.1.1	ko:K15986	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	CBS,DHH,DHHA2,DRTGG
k59_590649_1	215803.DB30_3984	3.28e-15	81.3	COG0642@1|root,COG5002@1|root,COG2205@2|Bacteria,COG5002@2|Bacteria,1QX6W@1224|Proteobacteria,42ZK5@68525|delta/epsilon subdivisions,2WUSH@28221|Deltaproteobacteria,2YXKX@29|Myxococcales	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4
k59_645342_1	94624.Bpet3749	2.74e-08	60.1	COG4948@1|root,COG4948@2|Bacteria,1MU8R@1224|Proteobacteria,2VH1R@28216|Betaproteobacteria,3T2AA@506|Alcaligenaceae	28216|Betaproteobacteria	G	Belongs to the mandelate racemase muconate lactonizing enzyme family	menC	-	4.2.1.113,5.5.1.1,5.5.1.7	ko:K01856,ko:K01860,ko:K02549	ko00130,ko00361,ko00362,ko00364,ko00623,ko01100,ko01110,ko01120,ko01220,map00130,map00361,map00362,map00364,map00623,map01100,map01110,map01120,map01220	M00116,M00568	R04031,R04259,R05300,R05390,R05392,R06834,R06840,R06989,R08116,R08119,R09135,R09215,R09217,R09221,R09229	RC00903,RC01038,RC01053,RC01108,RC01321,RC01356,RC01358,RC01687,RC02117,RC02448,RC02464,RC02465	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
k59_34915_1	1408473.JHXO01000006_gene1219	5.38e-44	155.0	COG3291@1|root,COG3291@2|Bacteria,4NJR6@976|Bacteroidetes,2FX54@200643|Bacteroidia	976|Bacteroidetes	S	Pkd domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_90746_1	1122132.AQYH01000004_gene1712	7.41e-97	299.0	COG1793@1|root,COG1793@2|Bacteria,1MV3S@1224|Proteobacteria,2TRQ9@28211|Alphaproteobacteria,4B9WI@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	DNA ligase	lig	-	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
k59_982097_1	1211112.ALJC01000051_gene2075	1.86e-62	212.0	COG1368@1|root,COG1368@2|Bacteria,1MVCM@1224|Proteobacteria,1RNJ3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
k59_1536015_1	439235.Dalk_4107	1.38e-31	122.0	COG3769@1|root,COG3769@2|Bacteria,1NFV5@1224|Proteobacteria,42SQA@68525|delta/epsilon subdivisions,2WP3P@28221|Deltaproteobacteria,2MM4B@213118|Desulfobacterales	28221|Deltaproteobacteria	S	haloacid dehalogenase-like hydrolase	-	-	3.1.3.70	ko:K07026	ko00051,map00051	-	R05790	RC00017	ko00000,ko00001,ko01000	-	-	-	Hydrolase_3
k59_200870_1	555079.Toce_1208	1.32e-26	105.0	COG1692@1|root,COG1692@2|Bacteria,1TR9P@1239|Firmicutes,24967@186801|Clostridia,42EQD@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM Metallophosphoesterase	-	-	-	ko:K09769	-	-	-	-	ko00000	-	-	-	YmdB
k59_1706942_1	580332.Slit_0183	6.48e-36	137.0	COG2027@1|root,COG2027@2|Bacteria,1MW40@1224|Proteobacteria,2VH20@28216|Betaproteobacteria,44VJM@713636|Nitrosomonadales	28216|Betaproteobacteria	M	PFAM peptidase S13 D-Ala-D-Ala carboxypeptidase C	dacB	-	3.4.16.4	ko:K07259	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S13
k59_646957_1	1121904.ARBP01000003_gene6312	3.57e-06	54.3	COG0457@1|root,COG2207@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2207@2|Bacteria,COG5616@2|Bacteria,4NFW7@976|Bacteroidetes	976|Bacteroidetes	K	COGs COG5616 integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,TPR_8
k59_1150035_1	1163407.UU7_10955	2.51e-73	228.0	COG3483@1|root,COG3483@2|Bacteria,1MW68@1224|Proteobacteria,1RXYM@1236|Gammaproteobacteria,1X3GY@135614|Xanthomonadales	135614|Xanthomonadales	E	Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety	kynA	GO:0003674,GO:0003824,GO:0004833,GO:0005488,GO:0006082,GO:0006084,GO:0006139,GO:0006163,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009117,GO:0009150,GO:0009259,GO:0009308,GO:0009310,GO:0009987,GO:0016043,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0019439,GO:0019441,GO:0019442,GO:0019637,GO:0019693,GO:0019752,GO:0020037,GO:0022607,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043436,GO:0043603,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046906,GO:0048037,GO:0051186,GO:0051213,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0055114,GO:0065003,GO:0070189,GO:0071704,GO:0071840,GO:0072521,GO:0097159,GO:1901135,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.13.11.11	ko:K00453	ko00380,ko01100,map00380,map01100	M00038	R00678	RC00356	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_dioxygenase
k59_316405_1	1316936.K678_06537	7.51e-86	275.0	COG0480@1|root,COG0480@2|Bacteria,1MU2W@1224|Proteobacteria,2TYVK@28211|Alphaproteobacteria,2JPGT@204441|Rhodospirillales	204441|Rhodospirillales	J	COG0480 Translation elongation factors (GTPases)	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU
k59_1317528_1	1049564.TevJSym_ax00490	5.8e-62	214.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1J5F8@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_759680_1	1242864.D187_000296	8e-73	235.0	COG1274@1|root,COG1274@2|Bacteria,1MX3C@1224|Proteobacteria,42PRT@68525|delta/epsilon subdivisions,2WIWH@28221|Deltaproteobacteria,2YU1K@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	-	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2638	PEPCK_C,PEPCK_N
k59_1594487_1	357809.Cphy_0596	1.41e-15	81.3	COG3181@1|root,COG3181@2|Bacteria,1UJHR@1239|Firmicutes,24Z3N@186801|Clostridia,2241Y@1506553|Lachnoclostridium	186801|Clostridia	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_1094019_1	1304885.AUEY01000005_gene896	2.42e-24	106.0	COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WJCX@28221|Deltaproteobacteria,2MHXT@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,MASE2,PAS_4,PAS_9,Response_reg
k59_202612_1	991905.SL003B_1383	1.09e-82	259.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2TQPZ@28211|Alphaproteobacteria,4BPCV@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	O	Belongs to the peptidase S1C family	degP	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ,PDZ_2,Trypsin_2
k59_1262477_1	251221.35211187	2.34e-72	239.0	COG1505@1|root,COG1505@2|Bacteria,1G1B7@1117|Cyanobacteria	1117|Cyanobacteria	E	PFAM Prolyl oligopeptidase, N-terminal beta-propeller domain	-	-	3.4.21.26	ko:K01322	ko04614,map04614	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
k59_705428_1	1121939.L861_04720	7.72e-86	266.0	COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,1RN2A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	The glycine cleavage system catalyzes the degradation of glycine	-	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
k59_1150077_1	378806.STAUR_4681	1.4e-17	79.7	COG0131@1|root,COG0131@2|Bacteria,1MWBS@1224|Proteobacteria,42NIV@68525|delta/epsilon subdivisions,2WNA4@28221|Deltaproteobacteria,2YV6W@29|Myxococcales	28221|Deltaproteobacteria	E	Imidazoleglycerol-phosphate dehydratase	hisB	GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.19	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03457	RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPD
k59_1150077_2	1297742.A176_00298	3.51e-20	88.6	COG0106@1|root,COG0106@2|Bacteria,1MW6S@1224|Proteobacteria,42NGZ@68525|delta/epsilon subdivisions,2WKRM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Histidine biosynthesis protein	hisA	-	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
k59_36567_1	749927.AMED_1012	1.04e-15	79.3	COG0438@1|root,COG0438@2|Bacteria,2GMEW@201174|Actinobacteria,4DXDI@85010|Pseudonocardiales	201174|Actinobacteria	M	PFAM Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
k59_426247_1	515635.Dtur_0186	3.38e-42	154.0	COG0312@1|root,COG0312@2|Bacteria	2|Bacteria	S	metallopeptidase activity	tldD2	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
k59_258629_1	1455608.JDTH01000002_gene1084	5.36e-16	82.8	COG2234@1|root,arCOG02959@2157|Archaea,2XUB0@28890|Euryarchaeota,23T4N@183963|Halobacteria	183963|Halobacteria	S	Peptidase M28	ywaD1	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
k59_537579_1	755732.Fluta_3961	3.8e-76	243.0	COG3666@1|root,COG3666@2|Bacteria,4NEDD@976|Bacteroidetes,1HYXT@117743|Flavobacteriia,2PC3Q@246874|Cryomorphaceae	976|Bacteroidetes	L	COGs COG3666 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_1647570_1	46681.XP_001739762.1	2.01e-27	112.0	COG1028@1|root,KOG0725@2759|Eukaryota,3X95G@554915|Amoebozoa	554915|Amoebozoa	Q	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_484225_1	861299.J421_0211	7.14e-18	87.8	COG0577@1|root,COG0577@2|Bacteria	861299.J421_0211|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_604797_1	331869.BAL199_17798	4.7e-118	346.0	COG3638@1|root,COG3638@2|Bacteria,1MVE9@1224|Proteobacteria,2TRR3@28211|Alphaproteobacteria,4BPIS@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	P	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system	phnC	-	3.6.3.28	ko:K02041	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.9	-	-	ABC_tran
k59_1549703_1	1120956.JHZK01000029_gene79	4e-23	96.7	COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,2TQNG@28211|Alphaproteobacteria,1JN3K@119043|Rhodobiaceae	28211|Alphaproteobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
k59_1549703_2	991905.SL003B_0917	5.68e-54	176.0	COG0632@1|root,COG0632@2|Bacteria,1MWJR@1224|Proteobacteria,2TSKM@28211|Alphaproteobacteria,4BQE1@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
k59_1332663_1	1131269.AQVV01000012_gene2570	9.23e-29	117.0	COG3267@1|root,COG3267@2|Bacteria	2|Bacteria	-	-	exeA	-	-	ko:K02450	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22,PG_binding_1
k59_996749_2	1219035.NT2_02_05880	5.42e-14	74.3	COG1920@1|root,COG1920@2|Bacteria	2|Bacteria	S	nucleotidyltransferase activity	cofC	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0043814,GO:0044237,GO:0044249,GO:0051186,GO:0051188,GO:0070568	2.7.7.68	ko:K14941	ko00680,ko01120,map00680,map01120	M00378	R09397	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CofC,NTP_transf_3
k59_439870_1	246197.MXAN_5852	1.35e-44	165.0	COG0591@1|root,COG4191@1|root,COG0591@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,43C82@68525|delta/epsilon subdivisions,2X7IE@28221|Deltaproteobacteria,2Z3GR@29|Myxococcales	28221|Deltaproteobacteria	T	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS_4
k59_1440856_1	1379698.RBG1_1C00001G0995	5.66e-38	146.0	COG5617@1|root,COG5617@2|Bacteria,2NS5H@2323|unclassified Bacteria	2|Bacteria	E	Bacterial membrane protein YfhO	-	-	-	-	-	-	-	-	-	-	-	-	YfhO
k59_1387047_1	864069.MicloDRAFT_00049420	1.57e-46	166.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,1JSYN@119045|Methylobacteriaceae	28211|Alphaproteobacteria	T	PFAM Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,TPR_16
k59_1719330_1	83406.HDN1F_13830	8.85e-48	169.0	COG2272@1|root,COG2272@2|Bacteria,1MVQZ@1224|Proteobacteria,1RPFW@1236|Gammaproteobacteria,1J8TD@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	Belongs to the type-B carboxylesterase lipase family	estA1	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase
k59_1332690_1	880073.Calab_3570	6.53e-99	307.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,2NNR2@2323|unclassified Bacteria	2|Bacteria	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	GO:0003674,GO:0003824,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0052855,GO:0052856,GO:0052857	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
k59_1387067_1	378806.STAUR_5205	1.66e-71	233.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,42NY8@68525|delta/epsilon subdivisions,2WJNT@28221|Deltaproteobacteria,2YXXC@29|Myxococcales	28221|Deltaproteobacteria	E	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k59_331789_1	1120983.KB894574_gene1010	5.98e-60	196.0	COG0697@1|root,COG0697@2|Bacteria,1MWSU@1224|Proteobacteria,2TSWT@28211|Alphaproteobacteria,1JNSU@119043|Rhodobiaceae	28211|Alphaproteobacteria	EG	EamA-like transporter family	MA20_03510	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_214576_1	251221.35214577	1.53e-58	199.0	COG0249@1|root,COG0249@2|Bacteria	2|Bacteria	L	mismatched DNA binding	mutS1	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_III,MutS_V
k59_772254_1	76114.p2A133	2.58e-147	429.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,2W317@28216|Betaproteobacteria	28216|Betaproteobacteria	H	3-octaprenyl-4-hydroxybenzoate carboxy-lyase	-	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
k59_885873_1	436717.AOLE_16100	1.03e-82	259.0	COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,1RQAM@1236|Gammaproteobacteria,3NMIP@468|Moraxellaceae	1236|Gammaproteobacteria	S	Peptidase dimerisation domain	hipO	-	-	ko:K01436	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
k59_439929_2	1207055.C100_05545	9.46e-06	50.4	COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,2TTPH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Dienelactone hydrolase	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
k59_1387106_1	661087.HMPREF1008_01773	3.66e-26	110.0	COG0624@1|root,COG0624@2|Bacteria,2IS2G@201174|Actinobacteria,4CXDU@84998|Coriobacteriia	84998|Coriobacteriia	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
k59_1217640_1	326427.Cagg_1166	1.39e-82	262.0	COG2414@1|root,COG2414@2|Bacteria,2G5XP@200795|Chloroflexi,376PZ@32061|Chloroflexia	32061|Chloroflexia	C	PFAM aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
k59_270992_1	649764.HMPREF0762_00157	2.72e-07	57.0	COG1597@1|root,COG1597@2|Bacteria,2HH18@201174|Actinobacteria,4CUXW@84998|Coriobacteriia	84998|Coriobacteriia	I	diacylglycerol kinase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
k59_1165267_1	555088.DealDRAFT_2584	2.56e-16	81.3	COG1947@1|root,COG1947@2|Bacteria,1TPXV@1239|Firmicutes,24898@186801|Clostridia,42JVK@68298|Syntrophomonadaceae	186801|Clostridia	F	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	-	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
k59_1165267_2	1205680.CAKO01000010_gene4012	5.9e-05	45.1	COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,2TRD9@28211|Alphaproteobacteria,2JPC9@204441|Rhodospirillales	204441|Rhodospirillales	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
k59_604858_1	66869.JNXG01000003_gene3013	2.25e-35	136.0	COG0281@1|root,COG0281@2|Bacteria,2GJAJ@201174|Actinobacteria,417FE@629295|Streptomyces griseus group	201174|Actinobacteria	C	Malic enzyme, NAD binding domain	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	Malic_M,malic
k59_720664_1	526222.Desal_3312	6.24e-22	95.9	COG3437@1|root,COG3437@2|Bacteria,1QUN9@1224|Proteobacteria,42PB6@68525|delta/epsilon subdivisions,2WJJ9@28221|Deltaproteobacteria,2M8RX@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	SMART Metal-dependent phosphohydrolase, HD region	-	-	-	-	-	-	-	-	-	-	-	-	DUF3369,HD,HD_5,Response_reg
k59_604875_1	472759.Nhal_3328	6.08e-52	176.0	COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,1RPCE@1236|Gammaproteobacteria,1WXFS@135613|Chromatiales	1236|Gammaproteobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_1719378_1	1040989.AWZU01000008_gene3649	2.11e-12	69.3	COG0697@1|root,COG0697@2|Bacteria,1MXX1@1224|Proteobacteria,2VED8@28211|Alphaproteobacteria,3JWVQ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_659967_1	1201292.DR75_829	2.17e-55	182.0	COG0413@1|root,COG0413@2|Bacteria,1TPZA@1239|Firmicutes,4H9S8@91061|Bacilli,4B4UX@81852|Enterococcaceae	91061|Bacilli	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
k59_1773789_1	926569.ANT_18060	9.79e-59	205.0	COG0166@1|root,COG0176@1|root,COG0166@2|Bacteria,COG0176@2|Bacteria,2G67J@200795|Chloroflexi	200795|Chloroflexi	G	Belongs to the GPI family	pgi	-	2.2.1.2,5.3.1.9	ko:K01810,ko:K13810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00004,M00007,M00114	R01827,R02739,R02740,R03321	RC00376,RC00439,RC00563,RC00604	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI,TAL_FSA
k59_1387164_1	500153.JOEK01000004_gene723	1.08e-33	125.0	COG0500@1|root,COG2226@2|Bacteria,2I35J@201174|Actinobacteria	201174|Actinobacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
k59_550598_1	690597.JH730938_gene2092	1.3e-37	144.0	COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1YPZA@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	T	Histidine kinase	sagS	-	2.7.13.3	ko:K20973	ko02020,ko02025,map02020,map02025	M00820	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,Response_reg
k59_498923_2	935840.JAEQ01000002_gene3674	3.2e-85	253.0	COG0049@1|root,COG0049@2|Bacteria,1MXC8@1224|Proteobacteria,2TSI8@28211|Alphaproteobacteria,43GWQ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
k59_498923_3	744980.TRICHSKD4_4991	9.09e-23	90.9	COG0048@1|root,COG0048@2|Bacteria,1RCWY@1224|Proteobacteria,2U70K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit	rpsL	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
k59_659982_2	1316936.K678_14632	4.29e-59	204.0	COG0086@1|root,COG0739@1|root,COG0086@2|Bacteria,COG0739@2|Bacteria,1MU3M@1224|Proteobacteria,2TRHV@28211|Alphaproteobacteria,2JQ0E@204441|Rhodospirillales	204441|Rhodospirillales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_498939_1	640511.BC1002_3261	3.29e-22	99.8	COG2079@1|root,COG2079@2|Bacteria,1R5UM@1224|Proteobacteria,2VI2F@28216|Betaproteobacteria,1K5T8@119060|Burkholderiaceae	28216|Betaproteobacteria	S	MmgE PrpD family protein	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
k59_720713_1	349163.Acry_0378	1.09e-20	90.9	COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,2TR48@28211|Alphaproteobacteria,2JPF3@204441|Rhodospirillales	204441|Rhodospirillales	D	COG1674 DNA segregation ATPase FtsK SpoIIIE and related proteins	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
k59_720713_2	1122135.KB893134_gene3193	2.61e-25	103.0	COG2834@1|root,COG2834@2|Bacteria,1RA1S@1224|Proteobacteria,2U58W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	lolA	-	-	-	-	-	-	-	-	-	-	-	LolA
k59_885993_1	1318628.MARLIPOL_15924	1.37e-21	89.7	2E31J@1|root,32Y1Y@2|Bacteria,1N745@1224|Proteobacteria,1SCMM@1236|Gammaproteobacteria,46B7F@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	MAPEG family	-	-	-	-	-	-	-	-	-	-	-	-	MAPEG
k59_498947_1	545276.KB898729_gene1605	3.68e-21	90.1	COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,1RNWJ@1236|Gammaproteobacteria,1WW4K@135613|Chromatiales	135613|Chromatiales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
k59_498947_2	395493.BegalDRAFT_3131	2.21e-74	236.0	COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,1RN6U@1236|Gammaproteobacteria,46017@72273|Thiotrichales	72273|Thiotrichales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_331934_1	1380394.JADL01000014_gene225	1.75e-89	287.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,2JPID@204441|Rhodospirillales	204441|Rhodospirillales	T	signal transduction histidine kinase	-	-	2.7.13.3	ko:K13587	ko02020,ko04112,map02020,map04112	M00512	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS_4,PAS_8,PAS_9,Response_reg
k59_216334_1	1329516.JPST01000022_gene2589	1.03e-51	174.0	COG1175@1|root,COG1175@2|Bacteria,1UVVT@1239|Firmicutes,4HCKP@91061|Bacilli,27CQW@186824|Thermoactinomycetaceae	91061|Bacilli	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K17316	ko02010,map02010	M00605	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.24,3.A.1.1.30	-	-	BPD_transp_1
k59_662078_1	869210.Marky_1897	4.86e-36	138.0	COG0719@1|root,COG0719@2|Bacteria,1WJ1E@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	O	TIGRFAM FeS assembly protein SufD	-	-	-	ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
k59_662080_1	861299.J421_0477	1.06e-45	160.0	COG0859@1|root,COG0859@2|Bacteria,1ZT3G@142182|Gemmatimonadetes	2|Bacteria	M	Glycosyltransferase family 9 (heptosyltransferase)	opsX	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	-	ko:K02841,ko:K02843,ko:K02849,ko:K12982	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
k59_1389461_1	1869.MB27_24170	4.24e-46	163.0	COG0624@1|root,COG0624@2|Bacteria,2GM84@201174|Actinobacteria,4D8NU@85008|Micromonosporales	201174|Actinobacteria	E	Peptidase dimerisation domain	argE	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
k59_552232_1	1123229.AUBC01000001_gene1837	1.65e-24	100.0	2E61B@1|root,330QK@2|Bacteria,1N39M@1224|Proteobacteria,2U8C9@28211|Alphaproteobacteria,3JZ9V@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1219285_1	761193.Runsl_0369	4.39e-42	157.0	COG2866@1|root,COG2866@2|Bacteria,4NGIE@976|Bacteroidetes,47N2M@768503|Cytophagia	976|Bacteroidetes	E	Zinc carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
k59_386749_1	335543.Sfum_3546	4.88e-85	278.0	COG1216@1|root,COG3250@1|root,COG1216@2|Bacteria,COG3250@2|Bacteria,1R42U@1224|Proteobacteria,42UMM@68525|delta/epsilon subdivisions,2WQVW@28221|Deltaproteobacteria,2MS0N@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_2_C,Glycos_transf_2
k59_1776296_1	1211115.ALIQ01000161_gene3832	1.28e-19	92.4	COG2270@1|root,COG2270@2|Bacteria,1MWXB@1224|Proteobacteria,2TSCV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Major facilitator superfamily	MA20_25070	-	-	ko:K06902	ko04138,map04138	-	-	-	ko00000,ko00001,ko02000,ko04131	2.A.1.24,9.A.15.1	-	-	ATG22
k59_662127_1	877418.ATWV01000005_gene2590	8.31e-26	113.0	COG1293@1|root,COG1293@2|Bacteria,2J61Z@203691|Spirochaetes	203691|Spirochaetes	K	Fibrinogen-binding protein	FbpA	-	-	-	-	-	-	-	-	-	-	-	DUF814,FbpA
k59_1776302_1	56780.SYN_00924	1.73e-57	196.0	COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,42M90@68525|delta/epsilon subdivisions,2WJ9G@28221|Deltaproteobacteria,2MQW7@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
k59_552259_1	693661.Arcve_1522	3.09e-28	107.0	COG1413@1|root,arCOG01917@1|root,arCOG01917@2157|Archaea,arCOG02966@2157|Archaea,2Y47E@28890|Euryarchaeota,24778@183980|Archaeoglobi	183980|Archaeoglobi	T	HEAT repeats	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
k59_1663457_1	36875.HQ29_08935	1.73e-20	95.5	COG2071@1|root,COG2355@1|root,COG2071@2|Bacteria,COG2355@2|Bacteria,4NEBG@976|Bacteroidetes,2FMPY@200643|Bacteroidia,22X2P@171551|Porphyromonadaceae	976|Bacteroidetes	E	Membrane dipeptidase (Peptidase family M19)	-	-	3.4.13.19	ko:K01273,ko:K01274	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_C26,Peptidase_M19
k59_1609976_1	999423.HMPREF9161_00369	8.28e-80	258.0	COG0595@1|root,COG0595@2|Bacteria,1TQ9G@1239|Firmicutes,4H1Y7@909932|Negativicutes	909932|Negativicutes	S	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,RMMBL
k59_662138_1	649638.Trad_0840	1.33e-83	271.0	COG1012@1|root,COG1012@2|Bacteria,1WIGH@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_442361_1	1459636.NTE_03299	1.12e-39	136.0	arCOG08025@1|root,arCOG08025@2157|Archaea,41STV@651137|Thaumarchaeota	651137|Thaumarchaeota	S	zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	zinc_ribbon_2
k59_606618_2	882083.SacmaDRAFT_2255	4.76e-49	169.0	COG0568@1|root,COG0568@2|Bacteria,2GK3Z@201174|Actinobacteria,4DY5T@85010|Pseudonocardiales	201174|Actinobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	sigB	GO:0000988,GO:0000990,GO:0001666,GO:0002791,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009410,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010565,GO:0010604,GO:0010628,GO:0016020,GO:0016987,GO:0019216,GO:0019217,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032879,GO:0032880,GO:0036293,GO:0040007,GO:0042221,GO:0043175,GO:0043254,GO:0044087,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050708,GO:0050789,GO:0050794,GO:0050896,GO:0051046,GO:0051049,GO:0051128,GO:0051171,GO:0051173,GO:0051223,GO:0051252,GO:0051254,GO:0060255,GO:0062012,GO:0065007,GO:0070063,GO:0070201,GO:0070482,GO:0071944,GO:0080090,GO:0090087,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:1903530,GO:2000112,GO:2000142,GO:2001141	-	ko:K03086,ko:K03087	ko02026,ko05111,map02026,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_1219324_1	360910.BAV2831	8.09e-16	79.3	COG0657@1|root,COG0657@2|Bacteria,1NJ5J@1224|Proteobacteria,2WEXR@28216|Betaproteobacteria,3T73B@506|Alcaligenaceae	28216|Betaproteobacteria	I	alpha/beta hydrolase fold	-	-	3.5.1.9	ko:K01432	ko00380,ko00630,ko01100,map00380,map00630,map01100	M00038	R00988,R01959,R04911	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_3
k59_1219324_2	1122603.ATVI01000008_gene2213	1.73e-34	126.0	COG1305@1|root,COG1305@2|Bacteria,1R9XR@1224|Proteobacteria,1S4S3@1236|Gammaproteobacteria,1X66X@135614|Xanthomonadales	135614|Xanthomonadales	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
k59_1663475_1	1120999.JONM01000003_gene2564	7.25e-42	142.0	COG2259@1|root,COG2259@2|Bacteria,1N06A@1224|Proteobacteria,2VU8E@28216|Betaproteobacteria,2KRN7@206351|Neisseriales	206351|Neisseriales	S	DoxX	-	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
k59_831567_1	1307761.L21SP2_2698	9.11e-05	50.4	COG0642@1|root,COG3292@1|root,COG2205@2|Bacteria,COG3292@2|Bacteria	2|Bacteria	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF,HATPase_c,HisKA,HisKA_3,Hpt,Reg_prop,Response_reg,Y_Y_Y
k59_1056169_1	1267533.KB906736_gene1468	1.84e-86	263.0	COG0702@1|root,COG0702@2|Bacteria	2|Bacteria	GM	epimerase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10,NmrA
k59_1551615_1	1457250.BBMO01000001_gene1905	3.5e-52	182.0	COG1672@1|root,arCOG03166@2157|Archaea,2XTP2@28890|Euryarchaeota,23TEI@183963|Halobacteria	183963|Halobacteria	S	ATPase (AAA superfamily)	-	-	-	ko:K06921	-	-	-	-	ko00000	-	-	-	ATPase_2,DUF234
k59_831585_1	290397.Adeh_3502	1.22e-11	69.3	COG1073@1|root,COG1073@2|Bacteria,1MY4C@1224|Proteobacteria,42TB9@68525|delta/epsilon subdivisions,2WXEF@28221|Deltaproteobacteria,2YW3Y@29|Myxococcales	28221|Deltaproteobacteria	S	X-Pro dipeptidyl-peptidase (S15 family)	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4
k59_552287_1	1499968.TCA2_5028	4.97e-08	59.7	COG0855@1|root,COG0855@2|Bacteria,1TNZM@1239|Firmicutes,4HA88@91061|Bacilli,26SKK@186822|Paenibacillaceae	91061|Bacilli	P	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
k59_442399_1	1149133.ppKF707_6095	1.07e-99	302.0	COG3547@1|root,COG3547@2|Bacteria	2|Bacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_662182_1	324602.Caur_0535	6.97e-20	91.7	COG0392@1|root,COG0392@2|Bacteria,2G5KF@200795|Chloroflexi,374YY@32061|Chloroflexia	32061|Chloroflexia	S	PFAM conserved	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
k59_164219_1	94624.Bpet2987	3.16e-31	129.0	COG0045@1|root,COG1042@1|root,COG5361@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG5361@2|Bacteria,1MW98@1224|Proteobacteria,2VI9R@28216|Betaproteobacteria,3T1F4@506|Alcaligenaceae	28216|Betaproteobacteria	C	CoA binding domain	-	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
k59_1617719_1	1280686.AUKE01000002_gene1159	1.37e-63	211.0	COG0481@1|root,COG0481@2|Bacteria,1TP0G@1239|Firmicutes,247V8@186801|Clostridia,4BX9G@830|Butyrivibrio	186801|Clostridia	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
k59_506094_1	207954.MED92_17660	7.89e-93	282.0	COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,1RMAW@1236|Gammaproteobacteria,1XHDH@135619|Oceanospirillales	135619|Oceanospirillales	F	carbamoyl-phosphate synthetase glutamine chain	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
k59_172418_1	1040983.AXAE01000030_gene6202	1.8e-18	88.6	COG3745@1|root,COG3745@2|Bacteria,1MYVE@1224|Proteobacteria,2U7QC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	U	Pilus assembly protein CpaB	-	-	-	ko:K02279	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	RcpC,SAF
k59_1395478_1	438753.AZC_0947	2.48e-85	270.0	COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,2TQWI@28211|Alphaproteobacteria,3EY2P@335928|Xanthobacteraceae	28211|Alphaproteobacteria	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
k59_783953_2	1317124.DW2_00215	3.27e-08	55.1	COG3462@1|root,COG3462@2|Bacteria	2|Bacteria	S	membrane protein (DUF2078)	-	-	-	ko:K08982	-	-	-	-	ko00000	-	-	-	SHOCT
k59_839431_1	485913.Krac_9291	3.41e-50	179.0	COG3464@1|root,COG3464@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	UPF0236
k59_1395491_1	1169152.AXVD01000046_gene2908	2.23e-60	197.0	COG2141@1|root,COG2141@2|Bacteria,2H0K9@201174|Actinobacteria,4FXZ1@85025|Nocardiaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_1339968_1	1134474.O59_002065	1.78e-44	164.0	COG0116@1|root,COG1092@1|root,COG0116@2|Bacteria,COG1092@2|Bacteria,1MUQM@1224|Proteobacteria,1RNMH@1236|Gammaproteobacteria,1FGA7@10|Cellvibrio	1236|Gammaproteobacteria	J	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA	rlmL	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008990,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.173,2.1.1.264	ko:K12297	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM,THUMP,UPF0020
k59_1617750_1	368407.Memar_1051	9.76e-11	67.8	COG3187@1|root,arCOG03952@2157|Archaea,2Y55P@28890|Euryarchaeota,2NBFA@224756|Methanomicrobia	224756|Methanomicrobia	O	META domain	-	-	-	-	-	-	-	-	-	-	-	-	META
k59_228157_1	883069.HMPREF9238_00173	0.000879	44.3	COG0342@1|root,COG0342@2|Bacteria,2GJTT@201174|Actinobacteria,4D365@85005|Actinomycetales	201174|Actinobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
k59_228157_2	1123250.KB908388_gene166	7.69e-15	70.5	COG1862@1|root,COG1862@2|Bacteria	2|Bacteria	U	protein transport	yajC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031522,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
k59_728661_1	1056820.KB900632_gene2254	4.92e-20	85.5	2E80T@1|root,332F0@2|Bacteria,1N7RY@1224|Proteobacteria,1SCE8@1236|Gammaproteobacteria,2PNR9@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4389
k59_728661_2	663610.JQKO01000004_gene2882	3.85e-45	161.0	COG1850@1|root,COG1850@2|Bacteria,1MWEB@1224|Proteobacteria,2U466@28211|Alphaproteobacteria,3NC8P@45404|Beijerinckiaceae	28211|Alphaproteobacteria	G	Ribulose bisphosphate carboxylase large chain, catalytic domain	-	-	4.1.1.39	ko:K01601	ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200	M00165,M00166,M00532	R00024,R03140	RC00172,RC00859	ko00000,ko00001,ko00002,ko01000	-	-	-	RuBisCO_large
k59_172461_1	768671.ThimaDRAFT_1031	4.13e-30	116.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,1RMIR@1236|Gammaproteobacteria,1WWMP@135613|Chromatiales	135613|Chromatiales	M	PFAM peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_839465_1	159087.Daro_1867	8.48e-58	199.0	COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,2VHBQ@28216|Betaproteobacteria,2KUY6@206389|Rhodocyclales	206389|Rhodocyclales	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parE	-	-	ko:K02622	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_394858_1	56110.Oscil6304_5719	1.63e-39	151.0	COG0642@1|root,COG4251@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,COG4251@2|Bacteria,1G09B@1117|Cyanobacteria,1H82F@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	2.7.13.3	ko:K11527	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	GAF,GAF_3,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_9,Response_reg
k59_1506706_1	926569.ANT_16600	2.17e-27	112.0	COG0544@1|root,COG0544@2|Bacteria,2G6GA@200795|Chloroflexi	200795|Chloroflexi	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
k59_1451408_1	485915.Dret_1510	8.15e-32	128.0	COG2199@1|root,COG2203@1|root,COG2461@1|root,COG2203@2|Bacteria,COG2461@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,43CY0@68525|delta/epsilon subdivisions	1224|Proteobacteria	T	diguanylate cyclase	-	-	2.7.7.65	ko:K21020	ko02025,map02025	-	-	-	ko00000,ko00001,ko01000	-	-	-	GGDEF,PAS,PAS_3,PAS_4,PAS_9
k59_1451408_2	1313172.YM304_34760	3.17e-10	59.7	COG1669@1|root,COG1669@2|Bacteria,2HGH2@201174|Actinobacteria,4CNEF@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Nucleotidyltransferase domain	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	NTP_transf_2
k59_784021_1	1690.BPSG_1571	4.09e-28	113.0	COG1131@1|root,COG1131@2|Bacteria,2I2I7@201174|Actinobacteria,4CZE3@85004|Bifidobacteriales	201174|Actinobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1617791_1	1379270.AUXF01000001_gene2564	1.67e-111	332.0	COG0205@1|root,COG0205@2|Bacteria,1ZTAR@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfkA	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
k59_1284407_1	502025.Hoch_2000	3.07e-120	367.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,42MER@68525|delta/epsilon subdivisions,2WIYV@28221|Deltaproteobacteria,2YW7P@29|Myxococcales	28221|Deltaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2_2
k59_617181_1	683083.C414_000010013	2.45e-12	72.8	COG1495@1|root,COG1495@2|Bacteria,1R9CU@1224|Proteobacteria,42Q8M@68525|delta/epsilon subdivisions,2YN52@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	C	Disulfide bond formation protein DsbB	dsbI	-	-	ko:K03611	-	-	-	-	ko00000,ko03110	5.A.2.1	-	-	DsbB
k59_728705_1	631454.N177_1694	1.77e-53	184.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TVI3@28211|Alphaproteobacteria,1JN67@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	-	-	-	-	-	-	-	-	-	TctA
k59_61379_1	1122222.AXWR01000035_gene200	1.98e-23	102.0	COG0457@1|root,COG3271@1|root,COG0457@2|Bacteria,COG3271@2|Bacteria	2|Bacteria	S	peptidyl-tyrosine sulfation	exeA	-	-	ko:K02450	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22,DUF3335,PG_binding_1,Peptidase_C39_2,Peptidase_C70,VCBS
k59_673050_1	161156.JQKW01000008_gene600	5.1e-27	107.0	COG1189@1|root,COG1189@2|Bacteria,2GGSK@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	J	FtsJ-like methyltransferase	-	-	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
k59_1229428_1	266264.Rmet_0347	5.6e-31	125.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2VHFP@28216|Betaproteobacteria,1K0RB@119060|Burkholderiaceae	28216|Betaproteobacteria	M	TIGRFAM RND efflux system, outer membrane lipoprotein, NodT family	-	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_1061959_1	1120792.JAFV01000001_gene1803	5.66e-42	152.0	COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,2TR40@28211|Alphaproteobacteria,36XMQ@31993|Methylocystaceae	28211|Alphaproteobacteria	J	tRNA (Uracil-5-)-methyltransferase	rumA	-	2.1.1.190,2.1.1.35	ko:K00557,ko:K03215	-	-	-	-	ko00000,ko01000,ko03009,ko03016	-	-	-	tRNA_U5-meth_tr
k59_1395587_1	1121930.AQXG01000002_gene2155	1.86e-11	72.4	COG1629@1|root,COG1629@2|Bacteria,4PPDE@976|Bacteroidetes,1IYC1@117747|Sphingobacteriia	976|Bacteroidetes	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec
k59_728734_1	326427.Cagg_3315	2.62e-121	358.0	COG4806@1|root,COG4806@2|Bacteria,2GAHK@200795|Chloroflexi,37666@32061|Chloroflexia	32061|Chloroflexia	H	Belongs to the rhamnose isomerase family	rhaA	-	5.3.1.14	ko:K01813	ko00051,ko01120,map00051,map01120	-	R02437	RC00434	ko00000,ko00001,ko01000	-	-	-	RhaA
k59_673085_1	944435.AXAJ01000002_gene4569	7.64e-13	68.2	COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,2VPNX@28216|Betaproteobacteria,1K091@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Transcriptional regulator, LysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_673085_2	1547437.LL06_19690	1.98e-58	183.0	COG0662@1|root,COG0662@2|Bacteria,1R1DU@1224|Proteobacteria,2TZ1H@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Mannose-6-phosphate isomerase	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_172542_1	1142394.PSMK_18670	1.29e-67	228.0	COG1048@1|root,COG1048@2|Bacteria,2IY29@203682|Planctomycetes	203682|Planctomycetes	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k59_839538_1	1121374.KB891576_gene564	1.59e-14	78.2	COG0583@1|root,COG0583@2|Bacteria,1Q6E2@1224|Proteobacteria,1S4JH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	transcriptional regulator	gbpR	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_895528_1	1161401.ASJA01000023_gene172	9.46e-31	120.0	COG0457@1|root,COG0457@2|Bacteria,1NEP9@1224|Proteobacteria,2U5CT@28211|Alphaproteobacteria,440QS@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	Sulfotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_1,Sulfotransfer_3
k59_5990_1	356851.JOAN01000002_gene717	2.31e-28	107.0	COG3945@1|root,COG3945@2|Bacteria,2I92G@201174|Actinobacteria,4DDTU@85008|Micromonosporales	201174|Actinobacteria	S	Pfam:DUF385	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
k59_617237_1	479434.Sthe_1870	1.35e-52	177.0	COG2876@1|root,COG2876@2|Bacteria,2G643@200795|Chloroflexi,27XKF@189775|Thermomicrobia	189775|Thermomicrobia	E	NeuB family	-	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
k59_339148_1	706587.Desti_4746	8.67e-26	110.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,42MM9@68525|delta/epsilon subdivisions,2WJTT@28221|Deltaproteobacteria,2MQTZ@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
k59_673115_1	4113.PGSC0003DMT400027351	3.69e-15	82.8	COG1960@1|root,KOG0135@2759|Eukaryota,37M5X@33090|Viridiplantae,3GD9A@35493|Streptophyta,44H10@71274|asterids	35493|Streptophyta	IQ	Belongs to the acyl-CoA oxidase family	ACX6	GO:0000166,GO:0003674,GO:0003824,GO:0003995,GO:0003997,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0016627,GO:0016634,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050660,GO:0050662,GO:0051791,GO:0055114,GO:0071704,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901575	1.3.3.6	ko:K00232	ko00071,ko00592,ko01040,ko01100,ko01110,ko01212,ko03320,ko04024,ko04146,map00071,map00592,map01040,map01100,map01110,map01212,map03320,map04024,map04146	M00087,M00113	R01175,R01279,R03777,R03857,R03990,R04751,R04754,R07888,R07892,R07896,R07934,R07950	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000	-	-	-	ACOX,Acyl-CoA_dh_1,Acyl-CoA_dh_M
k59_1340103_1	656519.Halsa_1468	6.7e-28	117.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1TP98@1239|Firmicutes,248BJ@186801|Clostridia,3WAH1@53433|Halanaerobiales	186801|Clostridia	J	TIGRFAM phenylalanyl-tRNA synthetase, beta subunit	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA-synt_2d,tRNA_bind
k59_1284484_1	1379270.AUXF01000006_gene85	7.31e-80	248.0	COG0016@1|root,COG0016@2|Bacteria,1ZSQR@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Aminoacyl tRNA synthetase class II, N-terminal domain	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
k59_172580_1	288000.BBta_5249	3.31e-22	90.5	COG0640@1|root,COG0640@2|Bacteria,1RJ39@1224|Proteobacteria,2UA6C@28211|Alphaproteobacteria,3JZMH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
k59_61459_1	448385.sce0178	2.78e-27	114.0	COG1858@1|root,COG1858@2|Bacteria,1RC4D@1224|Proteobacteria	1224|Proteobacteria	C	cytochrome C peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1006695_1	383372.Rcas_3083	1.18e-118	352.0	COG0677@1|root,COG0677@2|Bacteria,2G5PP@200795|Chloroflexi,3756K@32061|Chloroflexia	32061|Chloroflexia	M	PFAM UDP-glucose GDP-mannose dehydrogenase	-	-	1.1.1.136	ko:K13015	ko00520,map00520	-	R00421	RC00291	ko00000,ko00001,ko01000,ko01005	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
k59_951051_1	671143.DAMO_0533	8.44e-208	616.0	COG0086@1|root,COG0086@2|Bacteria,2NNPR@2323|unclassified Bacteria	2|Bacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.6	ko:K03046,ko:K13797	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_1562482_1	351607.Acel_0445	4.95e-53	180.0	2B2J4@1|root,31V48@2|Bacteria,2IPFQ@201174|Actinobacteria,4EVJV@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_895603_1	861299.J421_3284	2.25e-44	163.0	COG1009@1|root,COG1009@2|Bacteria,1ZSZY@142182|Gemmatimonadetes	142182|Gemmatimonadetes	CP	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus	-	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
k59_6059_2	1435356.Y013_25170	2.89e-53	191.0	COG3328@1|root,COG3328@2|Bacteria,2GM8F@201174|Actinobacteria,4FX9W@85025|Nocardiaceae	201174|Actinobacteria	L	Transposase, Mutator family	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_283962_1	1123242.JH636434_gene3931	7.9e-13	68.9	COG1158@1|root,COG1158@2|Bacteria,2IXV3@203682|Planctomycetes	203682|Planctomycetes	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
k59_283962_2	452652.KSE_19060	9.35e-35	126.0	COG0778@1|root,COG0778@2|Bacteria,2GPB4@201174|Actinobacteria,2M1J0@2063|Kitasatospora	201174|Actinobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
k59_951073_1	243233.MCA1663	0.00027	45.4	COG1366@1|root,COG1366@2|Bacteria,1PTSM@1224|Proteobacteria,1SDRW@1236|Gammaproteobacteria,1XGUJ@135618|Methylococcales	135618|Methylococcales	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	-	-	-	-	-	-	-	-	-	STAS
k59_1506891_1	251221.35214577	3.2e-37	140.0	COG0249@1|root,COG0249@2|Bacteria	2|Bacteria	L	mismatched DNA binding	mutS1	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_III,MutS_V
k59_784168_2	670487.Ocepr_0084	4.29e-14	75.1	COG0554@1|root,COG0554@2|Bacteria,1WI6Q@1297|Deinococcus-Thermus	2|Bacteria	C	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	-	-	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
k59_673186_1	1123373.ATXI01000021_gene926	3.2e-78	247.0	COG0038@1|root,COG0038@2|Bacteria,2GHV5@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	P	Voltage gated chloride channel	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,Voltage_CLC
k59_673191_1	393595.ABO_0383	7.04e-113	333.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,1RMYX@1236|Gammaproteobacteria,1XH22@135619|Oceanospirillales	135619|Oceanospirillales	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
k59_1617939_1	745411.B3C1_11339	4.18e-39	143.0	COG0845@1|root,COG0845@2|Bacteria,1R4JA@1224|Proteobacteria,1RPS5@1236|Gammaproteobacteria,1J60K@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
k59_1062083_1	477974.Daud_1532	8.17e-32	117.0	COG0350@1|root,COG0350@2|Bacteria,1VA03@1239|Firmicutes,24JAA@186801|Clostridia,262N2@186807|Peptococcaceae	186801|Clostridia	L	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	ogt	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1
k59_574060_1	926569.ANT_28280	1.29e-38	130.0	COG0361@1|root,COG0361@2|Bacteria,2G7AQ@200795|Chloroflexi	200795|Chloroflexi	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	-	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
k59_519204_1	944547.ABLL_2479	9.51e-13	72.8	COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,42MCP@68525|delta/epsilon subdivisions,2YMQE@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
k59_1464367_1	1996.JOFO01000004_gene3444	1.33e-60	198.0	COG0384@1|root,COG0384@2|Bacteria,2GM1W@201174|Actinobacteria,4EIXN@85012|Streptosporangiales	201174|Actinobacteria	S	Phenazine biosynthesis-like protein	phzF	-	5.3.3.17	ko:K06998	ko00405,ko01130,ko02024,map00405,map01130,map02024	M00835	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	PhzC-PhzF
k59_797299_1	1297742.A176_02282	1.5e-46	157.0	2ESNI@1|root,33K73@2|Bacteria,1Q2MV@1224|Proteobacteria,4388I@68525|delta/epsilon subdivisions,2X3I7@28221|Deltaproteobacteria,2YW7A@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2378
k59_129164_1	1218084.BBJK01000037_gene3506	8.6e-11	67.4	COG2079@1|root,COG2079@2|Bacteria,1NECN@1224|Proteobacteria,2VN65@28216|Betaproteobacteria,1K3BE@119060|Burkholderiaceae	28216|Betaproteobacteria	S	MmgE/PrpD family	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
k59_1074828_2	1231190.NA8A_21396	6.01e-33	116.0	2CXUS@1|root,32T2P@2|Bacteria,1MZIZ@1224|Proteobacteria,2UBZF@28211|Alphaproteobacteria,43PP0@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	YGGT
k59_1464381_1	414684.RC1_2667	2.03e-93	299.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2TTBF@28211|Alphaproteobacteria,2JR68@204441|Rhodospirillales	204441|Rhodospirillales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_464351_1	1267533.KB906734_gene4287	2.29e-25	108.0	COG0823@1|root,COG3710@1|root,COG0823@2|Bacteria,COG3710@2|Bacteria,3Y3FE@57723|Acidobacteria	57723|Acidobacteria	KU	WD40 domain protein beta Propeller	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Trans_reg_C
k59_1464383_1	398767.Glov_3665	2.24e-82	254.0	COG2801@1|root,COG2801@2|Bacteria,1MVC8@1224|Proteobacteria,42NJR@68525|delta/epsilon subdivisions,2WKAM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,HTH_Tnp_1,rve,rve_3
k59_18951_1	861299.J421_5626	1.64e-67	227.0	COG3408@1|root,COG3408@2|Bacteria	2|Bacteria	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N
k59_574095_1	311403.Arad_7168	5.32e-53	184.0	COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,2TU0R@28211|Alphaproteobacteria,4B7Q4@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
k59_1131312_2	1227497.C491_14917	0.000596	43.5	COG1266@1|root,arCOG02768@2157|Archaea,2XZ3X@28890|Euryarchaeota,23WZT@183963|Halobacteria	183963|Halobacteria	S	metal-dependent membrane protease	-	-	-	-	-	-	-	-	-	-	-	-	Abi
k59_1020106_1	1123073.KB899242_gene926	2.23e-62	213.0	COG3320@1|root,COG4221@1|root,COG3320@2|Bacteria,COG4221@2|Bacteria,1QSHC@1224|Proteobacteria,1RQP8@1236|Gammaproteobacteria,1X3FH@135614|Xanthomonadales	135614|Xanthomonadales	Q	Male sterility protein	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_4,adh_short
k59_464370_1	1379270.AUXF01000004_gene3290	3.45e-40	152.0	COG0457@1|root,COG0457@2|Bacteria,1ZU8U@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
k59_1464404_2	1123242.JH636435_gene2014	6.74e-06	50.1	COG0063@1|root,COG0063@2|Bacteria,2IYWH@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase
k59_797342_2	1366050.N234_01105	6.84e-84	256.0	COG1175@1|root,COG1175@2|Bacteria,1MWB7@1224|Proteobacteria,2VHA0@28216|Betaproteobacteria,1KHRY@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025,ko:K10237	ko02010,map02010	M00204,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.17	-	-	BPD_transp_1
k59_1243425_1	1237149.C900_00552	1.04e-110	334.0	COG0591@1|root,COG0591@2|Bacteria,4PKHI@976|Bacteroidetes,47MV2@768503|Cytophagia	976|Bacteroidetes	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
k59_18981_1	1267533.KB906735_gene5000	3.46e-20	84.0	COG2128@1|root,COG2128@2|Bacteria,3Y8RP@57723|Acidobacteria,2JNQT@204432|Acidobacteriia	204432|Acidobacteriia	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1741939_1	1122137.AQXF01000001_gene3004	5.69e-62	216.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MWGR@1224|Proteobacteria,2TRTE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EU	COG1506 Dipeptidyl aminopeptidases acylaminoacyl-peptidases	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
k59_1686667_1	1267535.KB906767_gene1079	3.34e-09	57.4	COG0499@1|root,COG0499@2|Bacteria,3Y2J2@57723|Acidobacteria,2JIFV@204432|Acidobacteriia	204432|Acidobacteriia	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
k59_1686667_2	379066.GAU_3853	3.4e-60	196.0	COG0500@1|root,COG0640@1|root,COG0640@2|Bacteria,COG2226@2|Bacteria,1ZTKD@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KQ	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5,Methyltransf_11
k59_1408778_1	1207063.P24_04734	3.45e-56	183.0	COG1319@1|root,COG1319@2|Bacteria,1MUDB@1224|Proteobacteria,2TRA8@28211|Alphaproteobacteria,2JQRH@204441|Rhodospirillales	204441|Rhodospirillales	C	CO dehydrogenase flavoprotein C-terminal domain	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
k59_1575345_1	590409.Dd586_0416	1.37e-09	59.7	COG2199@1|root,COG3706@2|Bacteria,1N9PI@1224|Proteobacteria,1RPY9@1236|Gammaproteobacteria,2JC27@204037|Dickeya	1236|Gammaproteobacteria	T	SMART GGDEF domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,dCache_1
k59_1297330_1	861299.J421_4031	2.25e-51	181.0	COG4658@1|root,COG4658@2|Bacteria	2|Bacteria	C	electron transport chain	-	-	1.6.5.8	ko:K00347,ko:K03614	-	-	-	-	ko00000,ko01000	-	-	-	Complex1_51K,NQR2_RnfD_RnfE,RnfC_N
k59_1131353_1	479434.Sthe_1585	4.61e-20	84.7	2EKS3@1|root,33EFV@2|Bacteria,2GBBM@200795|Chloroflexi,27YP9@189775|Thermomicrobia	189775|Thermomicrobia	S	Prokaryotic Cytochrome C oxidase subunit IV	-	-	1.9.3.1	ko:K02277	ko00190,ko01100,map00190,map01100	M00155	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.4	-	-	COX4_pro
k59_519284_1	502025.Hoch_3548	1.2e-108	332.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,42M4Z@68525|delta/epsilon subdivisions,2WJ0D@28221|Deltaproteobacteria,2YUHW@29|Myxococcales	28221|Deltaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_741808_1	1173263.Syn7502_01452	2.14e-25	105.0	COG2234@1|root,COG2234@2|Bacteria,1G1QW@1117|Cyanobacteria,1H0JN@1129|Synechococcus	1117|Cyanobacteria	S	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
k59_741808_2	391615.ABSJ01000004_gene630	2.23e-49	168.0	COG0628@1|root,COG0628@2|Bacteria,1MXXU@1224|Proteobacteria,1RQCM@1236|Gammaproteobacteria,1J4EG@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	AI-2E family transporter	tqsA	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0009372,GO:0009987,GO:0015562,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0044764,GO:0051179,GO:0051234,GO:0051704,GO:0055085,GO:0071944	-	ko:K11744	-	-	-	-	ko00000	-	-	-	AI-2E_transport
k59_629657_1	861299.J421_0332	5.12e-25	112.0	COG0577@1|root,COG0577@2|Bacteria	861299.J421_0332|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_797398_1	1366050.N234_01095	2.02e-73	234.0	COG1653@1|root,COG1653@2|Bacteria,1MU64@1224|Proteobacteria,2VJYY@28216|Betaproteobacteria	28216|Betaproteobacteria	G	ABC-type sugar transport system, periplasmic component	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
k59_1353115_1	1150469.RSPPHO_00603	5.19e-24	97.1	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,2U8YK@28211|Alphaproteobacteria,2JT2R@204441|Rhodospirillales	204441|Rhodospirillales	K	Cold shock protein domain	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
k59_1020182_1	653733.Selin_1736	2.19e-36	134.0	COG0568@1|root,COG0568@2|Bacteria	2|Bacteria	K	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	rpoS	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_19041_1	1150469.RSPPHO_01186	1.92e-07	57.8	COG0658@1|root,COG0658@2|Bacteria,1MUKF@1224|Proteobacteria,2TRD5@28211|Alphaproteobacteria,2JR1J@204441|Rhodospirillales	204441|Rhodospirillales	S	Competence protein	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131
k59_1020188_1	215803.DB30_7235	1.68e-30	123.0	COG0577@1|root,COG0577@2|Bacteria,1NREW@1224|Proteobacteria,433ZM@68525|delta/epsilon subdivisions,2X48T@28221|Deltaproteobacteria,2YYI5@29|Myxococcales	1224|Proteobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_1297373_1	1380390.JIAT01000010_gene4038	4.48e-54	183.0	COG0520@1|root,COG0520@2|Bacteria,2GN15@201174|Actinobacteria,4CS3P@84995|Rubrobacteria	84995|Rubrobacteria	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1353129_1	1367847.JCM7686_pAMI4p081	2.41e-24	100.0	COG1794@1|root,COG1794@2|Bacteria,1MV03@1224|Proteobacteria,2U86Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	aspartate racemase	-	-	5.1.1.13	ko:K01779	ko00250,ko01054,map00250,map01054	-	R00491	RC00302	ko00000,ko00001,ko01000	-	-	-	Asp_Glu_race
k59_1353129_2	1144310.PMI07_001922	6.19e-06	46.2	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	MA20_40050	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_3,Glyoxalase_4
k59_1519715_1	517418.Ctha_0156	1.37e-16	78.6	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_6,TetR_N
k59_1353151_1	1125725.HMPREF1325_1214	2.42e-87	281.0	COG0525@1|root,COG0525@2|Bacteria,2J659@203691|Spirochaetes	203691|Spirochaetes	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
k59_519348_1	861299.J421_5794	1.1e-71	244.0	COG0515@1|root,COG0515@2|Bacteria,1ZUMJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
k59_519358_1	319003.Bra1253DRAFT_06693	2.56e-48	175.0	COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,3JTQ7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DZR,Guanylate_cyc,SAM_1
k59_1020233_1	511145.b3255	8.99e-30	111.0	COG0511@1|root,COG0511@2|Bacteria,1RCXA@1224|Proteobacteria,1S3YP@1236|Gammaproteobacteria,3XM9J@561|Escherichia	1236|Gammaproteobacteria	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA	accB	GO:0003674,GO:0003824,GO:0003989,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009305,GO:0009987,GO:0016049,GO:0016053,GO:0016421,GO:0016874,GO:0016885,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901564,GO:1901576	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	iYL1228.KPN_03664	Biotin_lipoyl
k59_1020233_2	1288494.EBAPG3_9450	3.84e-19	80.1	COG0757@1|root,COG0757@2|Bacteria,1RDDT@1224|Proteobacteria,2VR4Y@28216|Betaproteobacteria,3738V@32003|Nitrosomonadales	28216|Betaproteobacteria	E	Catalyzes a trans-dehydration via an enolate intermediate	aroQ	-	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
k59_1408884_1	106370.Francci3_2621	2.38e-83	269.0	COG0178@1|root,COG0178@2|Bacteria,2GJUV@201174|Actinobacteria	201174|Actinobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA2	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
k59_1686776_1	926569.ANT_06350	9.32e-60	196.0	COG1091@1|root,COG1091@2|Bacteria,2G9A2@200795|Chloroflexi	200795|Chloroflexi	M	PFAM NAD-dependent epimerase dehydratase	-	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
k59_185331_1	365528.KB891208_gene3044	4.53e-18	88.6	COG0210@1|root,COG2887@1|root,COG0210@2|Bacteria,COG2887@2|Bacteria,2GM2E@201174|Actinobacteria,4ES9T@85013|Frankiales	201174|Actinobacteria	L	Belongs to the helicase family. UvrD subfamily	uvrD2	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
k59_1020255_1	641491.DND132_0847	1.53e-08	59.7	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,43D7Y@68525|delta/epsilon subdivisions,2X8EK@28221|Deltaproteobacteria,2M94S@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS_9,Response_reg
k59_964181_1	420246.GTNG_2656	3.91e-71	222.0	COG0745@1|root,COG0745@2|Bacteria,1TPWS@1239|Firmicutes,4H9KP@91061|Bacilli,1WE3S@129337|Geobacillus	91061|Bacilli	T	Transcriptional regulatory protein, C terminal	phoP	-	-	ko:K07658	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_519384_1	671143.DAMO_1319	1.02e-24	108.0	COG0457@1|root,COG3712@1|root,COG4773@1|root,COG0457@2|Bacteria,COG3712@2|Bacteria,COG4773@2|Bacteria	2|Bacteria	P	Receptor	-	-	-	ko:K02014,ko:K16087	-	-	-	-	ko00000,ko02000	1.B.14,1.B.14.2	-	-	FecR,Plug,STN,TPR_16,TPR_8,TonB_dep_Rec
k59_1408899_1	1000565.METUNv1_00762	5.89e-15	74.3	COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,2VIG2@28216|Betaproteobacteria,2KUKU@206389|Rhodocyclales	206389|Rhodocyclales	O	HflC and HflK could encode or regulate a protease	-	-	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7,HflK_N
k59_1408899_2	556269.ACDQ01000002_gene1061	3.57e-46	160.0	COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,2VI86@28216|Betaproteobacteria,473MT@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
k59_1464551_1	1123229.AUBC01000004_gene3273	9.72e-48	171.0	COG0444@1|root,COG1173@1|root,COG0444@2|Bacteria,COG1173@2|Bacteria,1R4KB@1224|Proteobacteria,2TR0J@28211|Alphaproteobacteria,3K2WY@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EP	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02031,ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,BPD_transp_1,OppC_N,oligo_HPY
k59_629744_1	69042.WH5701_01595	2.15e-71	228.0	COG0304@1|root,COG0304@2|Bacteria,1G1J5@1117|Cyanobacteria,1GZS9@1129|Synechococcus	1117|Cyanobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_1686805_1	861299.J421_6317	1.03e-21	99.0	COG0577@1|root,COG0577@2|Bacteria	861299.J421_6317|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1020273_1	358681.BBR47_25720	5.91e-62	209.0	COG1164@1|root,COG1164@2|Bacteria,1TQ5W@1239|Firmicutes,4HAN9@91061|Bacilli,26S9J@186822|Paenibacillaceae	91061|Bacilli	E	oligoendopeptidase F	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M3,Peptidase_M3_N
k59_1075047_2	529884.Rhola_00008190	1.27e-30	117.0	COG2519@1|root,COG2519@2|Bacteria,2GJPD@201174|Actinobacteria,4FKMF@85023|Microbacteriaceae	201174|Actinobacteria	J	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA	trmI	GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016426,GO:0016429,GO:0016740,GO:0016741,GO:0030488,GO:0031515,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234	2.1.1.219,2.1.1.220	ko:K07442	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	GCD14,GCD14_N
k59_74382_1	1089552.KI911559_gene758	3.67e-154	444.0	COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,2TRGP@28211|Alphaproteobacteria,2JQ4B@204441|Rhodospirillales	204441|Rhodospirillales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_1297486_1	658086.HMPREF0994_04973	2.72e-11	61.6	COG1725@1|root,COG1725@2|Bacteria,1V9ZC@1239|Firmicutes,24NTW@186801|Clostridia	186801|Clostridia	K	Transcriptional regulator	-	-	-	ko:K07979	-	-	-	-	ko00000,ko03000	-	-	-	GntR
k59_21166_2	1510531.JQJJ01000012_gene1657	4.67e-73	234.0	COG2317@1|root,COG2317@2|Bacteria,1MW7T@1224|Proteobacteria,2TSMY@28211|Alphaproteobacteria,3K3CS@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Carboxypeptidase Taq (M32) metallopeptidase	-	-	3.4.17.19	ko:K01299	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M32
k59_1521904_2	1173028.ANKO01000023_gene4405	3.76e-12	65.9	COG0497@1|root,COG0497@2|Bacteria,1G0D4@1117|Cyanobacteria,1H7ME@1150|Oscillatoriales	1117|Cyanobacteria	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SMC_N
k59_1355542_1	935261.JAGL01000019_gene602	2.42e-76	236.0	COG1129@1|root,COG1129@2|Bacteria,1P3ZB@1224|Proteobacteria,2VET1@28211|Alphaproteobacteria,43I52@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	ABC transporter	xylG	-	3.6.3.17	ko:K10545	ko02010,map02010	M00215	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.4	-	-	ABC_tran
k59_1037442_1	713586.KB900536_gene2604	1.78e-48	169.0	COG1003@1|root,COG1003@2|Bacteria,1MUDP@1224|Proteobacteria,1RND3@1236|Gammaproteobacteria,1WXB2@135613|Chromatiales	135613|Chromatiales	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	Aminotran_5,GDC-P
k59_1424463_1	1305732.JAGG01000001_gene1157	5.91e-23	95.5	COG0020@1|root,COG0020@2|Bacteria,2GJCP@201174|Actinobacteria,4FKY2@85023|Microbacteriaceae	201174|Actinobacteria	I	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS1	GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016020,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0030145,GO:0033850,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:1901576,GO:1901615,GO:1901617	2.5.1.31,2.5.1.68	ko:K00806,ko:K12503	ko00900,ko01110,map00900,map01110	-	R06447,R08528	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
k59_1424463_2	177437.HRM2_17730	1.04e-31	122.0	COG1272@1|root,COG1272@2|Bacteria,1PGRH@1224|Proteobacteria,42QU8@68525|delta/epsilon subdivisions,2X5Q5@28221|Deltaproteobacteria,2MJTG@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Haemolysin-III related	-	-	-	ko:K11068	-	-	-	-	ko00000,ko02042	-	-	-	HlyIII
k59_1202094_1	379066.GAU_0733	8.76e-12	71.6	COG4726@1|root,COG4726@2|Bacteria,1ZUS8@142182|Gemmatimonadetes	142182|Gemmatimonadetes	NU	Pilus assembly protein PilX	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1147577_1	861299.J421_3964	6.3e-74	226.0	COG5405@1|root,COG5405@2|Bacteria,1ZSVH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery	hslV	-	3.4.25.2	ko:K01419	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Proteasome
k59_589997_1	1380394.JADL01000007_gene4450	1.42e-31	129.0	COG2159@1|root,COG2159@2|Bacteria,1Q4XY@1224|Proteobacteria,2U25S@28211|Alphaproteobacteria,2JYB7@204441|Rhodospirillales	204441|Rhodospirillales	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
k59_200281_1	926569.ANT_24980	1.88e-63	216.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,2G5QR@200795|Chloroflexi	200795|Chloroflexi	J	phenylalanyl-tRNA synthetase beta subunit	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
k59_1535429_1	926569.ANT_19870	1.08e-132	385.0	COG2255@1|root,COG2255@2|Bacteria,2G5QQ@200795|Chloroflexi	200795|Chloroflexi	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
k59_644802_1	357808.RoseRS_3660	5.26e-101	327.0	COG1197@1|root,COG1197@2|Bacteria,2G5UW@200795|Chloroflexi,375DR@32061|Chloroflexia	32061|Chloroflexia	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_1202139_2	483219.LILAB_18035	4.47e-20	86.7	COG1428@1|root,COG1428@2|Bacteria,1RC50@1224|Proteobacteria	1224|Proteobacteria	F	Deoxynucleoside kinase	dgk	-	-	-	-	-	-	-	-	-	-	-	dNK
k59_1314643_1	926550.CLDAP_14310	7.73e-23	97.8	COG1022@1|root,COG1022@2|Bacteria,2G5S9@200795|Chloroflexi	200795|Chloroflexi	I	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
k59_1314643_2	1429916.X566_18165	1.32e-16	80.5	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,2TSDS@28211|Alphaproteobacteria,3JTSI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Branched-chain amino acid transport system / permease component	MA20_19445	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_423802_1	491915.Aflv_2030	4.34e-42	159.0	COG0247@1|root,COG0247@2|Bacteria,1TR46@1239|Firmicutes,4HAY9@91061|Bacilli,21W48@150247|Anoxybacillus	91061|Bacilli	C	4Fe-4S dicluster domain	glcF	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_8
k59_1535457_1	593750.Metfor_1327	5.2e-09	58.5	COG1371@1|root,arCOG04055@2157|Archaea	2157|Archaea	S	Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently	-	GO:0000394,GO:0003674,GO:0005488,GO:0005509,GO:0006139,GO:0006388,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008380,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:1901360	-	-	-	-	-	-	-	-	-	-	Archease
k59_1369387_1	1089552.KI911559_gene887	2.39e-51	166.0	COG0314@1|root,COG0314@2|Bacteria,1RGUX@1224|Proteobacteria,2U73K@28211|Alphaproteobacteria,2JS7M@204441|Rhodospirillales	204441|Rhodospirillales	H	COG0314 Molybdopterin converting factor, large subunit	moaE	-	2.8.1.12	ko:K03635	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE
k59_1369387_2	1230476.C207_03992	1.22e-10	62.8	COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,2TSX8@28211|Alphaproteobacteria,3JUVR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Iron-containing alcohol dehydrogenase	MA20_22910	-	1.3.1.32	ko:K00217	ko00361,ko00362,ko00364,ko00623,ko01100,ko01120,ko01220,map00361,map00362,map00364,map00623,map01100,map01120,map01220	-	R02988,R02989,R05355,R06848,R07781,R09137,R09138,R09223,R09224	RC00107,RC01335,RC01689,RC02442	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
k59_644838_1	1007103.AFHW01000025_gene331	2.64e-69	234.0	COG0383@1|root,COG0383@2|Bacteria,1TQEH@1239|Firmicutes,4HB2V@91061|Bacilli,26SFU@186822|Paenibacillaceae	91061|Bacilli	G	Alpha-mannosidase	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C
k59_1202162_1	1051632.TPY_0246	1.57e-25	108.0	COG0247@1|root,COG0247@2|Bacteria,1TR46@1239|Firmicutes,24AIF@186801|Clostridia	186801|Clostridia	C	PFAM Cysteine-rich domain	glcF	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_7,Fer4_8
k59_423819_1	1118054.CAGW01000081_gene2596	6.45e-67	217.0	COG0183@1|root,COG0183@2|Bacteria,1TP07@1239|Firmicutes,4H9RJ@91061|Bacilli,26RP3@186822|Paenibacillaceae	91061|Bacilli	I	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation	-	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K07508	ko00062,ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00062,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00085,M00087,M00088,M00095,M00373,M00374,M00375	R00238,R00391,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747	RC00004,RC00326,RC00405,RC01702	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_1424542_1	234267.Acid_6847	3.32e-55	195.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
k59_757368_1	1123405.AUMM01000011_gene1342	8.68e-07	56.6	COG0535@1|root,COG0535@2|Bacteria,1TR52@1239|Firmicutes,4HAY2@91061|Bacilli,26NDW@186821|Sporolactobacillaceae	91061|Bacilli	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	ko:K22227	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
k59_423825_1	186497.PF1856	1.02e-14	76.3	COG0168@1|root,arCOG04145@2157|Archaea,2XT89@28890|Euryarchaeota,2431A@183968|Thermococci	183968|Thermococci	P	Cation transport protein	-	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
k59_423825_2	335659.S23_05400	1.66e-08	54.3	COG3747@1|root,COG3747@2|Bacteria,1RBBT@1224|Proteobacteria,2UEMW@28211|Alphaproteobacteria,3K0S6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Phage terminase, small subunit	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_4
k59_813189_1	273063.STK_00520	2.59e-64	214.0	COG0043@1|root,arCOG01671@2157|Archaea,2XPU8@28889|Crenarchaeota	28889|Crenarchaeota	H	TIGRFAM UbiD family	-	-	-	-	-	-	-	-	-	-	-	-	UbiD
k59_200352_1	985054.JQEZ01000003_gene1101	1.45e-58	199.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VFPZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
k59_867495_1	512565.AMIS_32900	3.06e-121	363.0	COG2303@1|root,COG2303@2|Bacteria,2I5YA@201174|Actinobacteria,4DEJ3@85008|Micromonosporales	201174|Actinobacteria	E	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
k59_1369429_1	675635.Psed_3032	2.13e-42	151.0	COG0439@1|root,COG0439@2|Bacteria,2I2S0@201174|Actinobacteria,4DXG8@85010|Pseudonocardiales	201174|Actinobacteria	I	Biotin carboxylase C-terminal domain	-	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
k59_1369429_2	1500890.JQNL01000001_gene1459	1.8e-13	70.9	COG0511@1|root,COG0511@2|Bacteria,1RCXA@1224|Proteobacteria,1S3YP@1236|Gammaproteobacteria,1X67R@135614|Xanthomonadales	135614|Xanthomonadales	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA	accB	-	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
k59_1424577_1	1128421.JAGA01000001_gene2229	2.31e-63	215.0	COG1529@1|root,COG1529@2|Bacteria,2NNTR@2323|unclassified Bacteria	2|Bacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	mop	-	1.2.99.7	ko:K07469	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2
k59_1147696_1	43354.JOIJ01000027_gene3357	4.46e-09	59.7	COG1414@1|root,COG1414@2|Bacteria,2GM23@201174|Actinobacteria,4E0VJ@85010|Pseudonocardiales	201174|Actinobacteria	K	transcriptional regulator	allR	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
k59_1202218_1	1033802.SSPSH_002210	1.02e-46	152.0	COG2963@1|root,COG2963@2|Bacteria,1N1AA@1224|Proteobacteria,1SAUG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Escherichia coli O157 H7 ortholog	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_200383_1	366602.Caul_5358	1.67e-19	89.4	COG3547@1|root,COG3547@2|Bacteria,1Q4TE@1224|Proteobacteria,2TT7C@28211|Alphaproteobacteria,2KIIT@204458|Caulobacterales	204458|Caulobacterales	L	Transposase IS116/IS110/IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_20
k59_981286_1	1279019.ARQK01000037_gene1677	7.89e-44	151.0	COG0500@1|root,COG2226@2|Bacteria,1MYPU@1224|Proteobacteria,1SZ13@1236|Gammaproteobacteria,1X22Q@135613|Chromatiales	135613|Chromatiales	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_90177_1	224911.27352347	9.51e-95	288.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,2TR32@28211|Alphaproteobacteria,3JU0T@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_1091575_1	1528106.JRJE01000032_gene2869	1.14e-81	261.0	COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,2TRJS@28211|Alphaproteobacteria,2JRDM@204441|Rhodospirillales	204441|Rhodospirillales	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	-	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
k59_90186_1	1382306.JNIM01000001_gene441	2.23e-83	263.0	COG1884@1|root,COG1884@2|Bacteria,2G62T@200795|Chloroflexi	200795|Chloroflexi	I	TIGRFAM methylmalonyl-CoA mutase, large subunit	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
k59_813244_1	204669.Acid345_0280	7.11e-49	176.0	COG0574@1|root,COG0784@1|root,COG0574@2|Bacteria,COG0784@2|Bacteria,3Y7G5@57723|Acidobacteria	57723|Acidobacteria	G	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PPDK_N
k59_200398_3	596152.DesU5LDRAFT_2640	3.17e-27	108.0	COG1319@1|root,COG1319@2|Bacteria,1MVJS@1224|Proteobacteria,42RX4@68525|delta/epsilon subdivisions,2WNBJ@28221|Deltaproteobacteria,2M9BS@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM Molybdopterin dehydrogenase, FAD-binding	-	-	1.17.1.4	ko:K11178	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
k59_1535544_1	1298920.KI911353_gene2371	4.49e-11	67.4	COG1162@1|root,COG1162@2|Bacteria,1TPSQ@1239|Firmicutes,248R5@186801|Clostridia,21XXS@1506553|Lachnoclostridium	186801|Clostridia	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase,RsgA_N
k59_1591887_1	1121033.AUCF01000010_gene4477	3.26e-98	305.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,2TQSS@28211|Alphaproteobacteria,2JPUQ@204441|Rhodospirillales	204441|Rhodospirillales	CP	COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit	nuoL	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADH5_C,Proton_antipo_M,Proton_antipo_N
k59_1480842_1	123214.PERMA_0298	5.31e-84	273.0	COG0243@1|root,COG0243@2|Bacteria,2G4F5@200783|Aquificae	200783|Aquificae	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.7.7.2	ko:K00367,ko:K02567	ko00910,ko01120,map00910,map01120	M00529,M00530,M00531	R00791,R00798,R01106	RC02812	ko00000,ko00001,ko00002,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal
k59_867563_1	880073.Calab_1818	3.67e-45	158.0	COG0803@1|root,COG0803@2|Bacteria,2NPH3@2323|unclassified Bacteria	2|Bacteria	P	Belongs to the bacterial solute-binding protein 9 family	znuA	-	-	ko:K02077,ko:K09815,ko:K09818	ko02010,map02010	M00242,M00243,M00244	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15,3.A.1.15.3,3.A.1.15.5	-	-	ZnuA
k59_590159_1	483219.LILAB_10280	7.9e-45	159.0	COG0006@1|root,COG0006@2|Bacteria,1MVHD@1224|Proteobacteria	1224|Proteobacteria	E	Xaa-Pro aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M24
k59_867580_1	994479.GL877880_gene4140	2.21e-22	96.3	COG4222@1|root,COG4222@2|Bacteria,2GJN8@201174|Actinobacteria,4DYT6@85010|Pseudonocardiales	201174|Actinobacteria	S	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
k59_1535559_1	84531.JMTZ01000079_gene2158	2.48e-14	76.6	COG0500@1|root,COG2226@2|Bacteria,1PA5F@1224|Proteobacteria,1RY7A@1236|Gammaproteobacteria,1X53I@135614|Xanthomonadales	135614|Xanthomonadales	H	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway	bioC	-	2.1.1.197	ko:K02169	ko00780,ko01100,map00780,map01100	M00572	R09543	RC00003,RC00460	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11
k59_1645239_1	404589.Anae109_0900	5.17e-54	187.0	COG0514@1|root,COG0514@2|Bacteria,1MVGG@1224|Proteobacteria,42MV3@68525|delta/epsilon subdivisions,2WJZB@28221|Deltaproteobacteria,2YX5W@29|Myxococcales	28221|Deltaproteobacteria	L	DNA helicase	recQ	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,HTH_40,Helicase_C,RQC,RecQ_Zn_bind
k59_1704255_1	1128421.JAGA01000003_gene3664	1.14e-33	128.0	COG0531@1|root,COG0531@2|Bacteria	2|Bacteria	E	amino acid	steT	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease,AA_permease_2
k59_1704255_2	309801.trd_A0796	5.74e-33	124.0	COG2129@1|root,COG2129@2|Bacteria	2|Bacteria	L	metallophosphoesterase	-	-	-	ko:K07096,ko:K07496	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2,Metallophos_3
k59_1424664_1	1442599.JAAN01000045_gene2785	1.53e-20	96.7	COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,1RQM3@1236|Gammaproteobacteria,1X4AK@135614|Xanthomonadales	135614|Xanthomonadales	I	Cardiolipin synthase	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_2
k59_1091633_1	1123360.thalar_00538	3.77e-10	61.2	COG5285@1|root,COG5285@2|Bacteria,1MWD5@1224|Proteobacteria,2TWPJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Protein involved in biosynthesis of mitomycin antibiotics polyketide fumonisin	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
k59_1091633_2	381666.H16_A2078	2.52e-13	69.7	COG1804@1|root,COG1804@2|Bacteria,1QNB4@1224|Proteobacteria,2VKAD@28216|Betaproteobacteria,1KCHN@119060|Burkholderiaceae	28216|Betaproteobacteria	H	carnitine dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_200434_1	1123253.AUBD01000001_gene1674	1.02e-37	139.0	COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,1RNKK@1236|Gammaproteobacteria,1X32I@135614|Xanthomonadales	135614|Xanthomonadales	E	Acetylglutamate kinase	argB	GO:0003674,GO:0003824,GO:0004042,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016597,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.1,2.7.2.8	ko:K22478	ko00220,ko01210,ko01230,map00220,map01210,map01230	M00028,M00845	R00259,R02649	RC00002,RC00004,RC00043,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,NAT
k59_926762_1	1089552.KI911559_gene3253	5.92e-68	215.0	COG2010@1|root,COG2010@2|Bacteria,1MUCW@1224|Proteobacteria,2TQW1@28211|Alphaproteobacteria,2JPRY@204441|Rhodospirillales	204441|Rhodospirillales	C	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex	-	-	-	ko:K00406	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	Cytochrome_CBB3,FixP_N
k59_869902_1	1040989.AWZU01000018_gene2766	5.58e-31	119.0	COG0637@1|root,COG0637@2|Bacteria,1NSPA@1224|Proteobacteria,2U0W3@28211|Alphaproteobacteria,3JT7R@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	HAD-hyrolase-like	MA20_23860	-	-	-	-	-	-	-	-	-	-	-	HAD_2
k59_1317026_3	1082931.KKY_1516	1.53e-06	52.0	COG1680@1|root,COG1680@2|Bacteria,1NHIY@1224|Proteobacteria,2U0A3@28211|Alphaproteobacteria,3N7MK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_425711_1	580331.Thit_0896	2.41e-39	142.0	COG2264@1|root,COG2264@2|Bacteria,1TPKI@1239|Firmicutes,247VY@186801|Clostridia,42FBX@68295|Thermoanaerobacterales	186801|Clostridia	J	Ribosomal protein L11 methyltransferase	prmA	-	-	ko:K02687	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PrmA
k59_759182_2	945713.IALB_3149	9.83e-55	184.0	COG1236@1|root,COG1236@2|Bacteria	2|Bacteria	J	nucleic acid phosphodiester bond hydrolysis	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_2,Lactamase_B_6,RMMBL
k59_869920_1	240016.ABIZ01000001_gene5712	9.75e-54	189.0	COG2114@1|root,COG3903@1|root,COG2114@2|Bacteria,COG3903@2|Bacteria,46TZ3@74201|Verrucomicrobia	74201|Verrucomicrobia	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,NB-ARC
k59_1426473_1	985665.HPL003_02005	7.12e-22	96.7	COG0566@1|root,COG0566@2|Bacteria,1V3JP@1239|Firmicutes,4HCF5@91061|Bacilli,26SHX@186822|Paenibacillaceae	91061|Bacilli	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	spoU	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase,SpoU_sub_bind
k59_370012_1	1121033.AUCF01000009_gene1013	6.58e-23	102.0	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2TQY9@28211|Alphaproteobacteria,2JRIJ@204441|Rhodospirillales	204441|Rhodospirillales	S	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_1149579_1	1041159.AZUW01000001_gene3410	1.93e-24	94.0	2E3KZ@1|root,32YJ8@2|Bacteria,1N7A7@1224|Proteobacteria,2UFMR@28211|Alphaproteobacteria,4BG6V@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Putative prokaryotic signal transducing protein	MA20_42240	-	-	-	-	-	-	-	-	-	-	-	DUF2007
k59_1149579_2	1401328.P856_187	4.59e-45	157.0	COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,2TSDZ@28211|Alphaproteobacteria,2JPBP@204441|Rhodospirillales	204441|Rhodospirillales	H	Belongs to the FPP GGPP synthase family	ispB	-	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110	-	R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
k59_36075_1	1123072.AUDH01000005_gene1567	6.01e-40	154.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TWGU@28211|Alphaproteobacteria,2JPGD@204441|Rhodospirillales	204441|Rhodospirillales	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2
k59_718168_1	391625.PPSIR1_12958	2.63e-28	117.0	COG2268@1|root,COG2268@2|Bacteria,1QIR4@1224|Proteobacteria,42Q0N@68525|delta/epsilon subdivisions,2WJDJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Band 7 protein	-	-	-	ko:K07192	ko04910,map04910	-	-	-	ko00000,ko00001,ko03036,ko04131,ko04147	-	-	-	Band_7,Flot
k59_1717665_1	1193181.BN10_580037	2.25e-31	122.0	COG3696@1|root,COG3696@2|Bacteria,2I53X@201174|Actinobacteria,4FK2M@85021|Intrasporangiaceae	201174|Actinobacteria	P	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_602901_1	1307761.L21SP2_2407	2.73e-41	152.0	COG2838@1|root,COG2838@2|Bacteria	2|Bacteria	C	Isocitrate dehydrogenase	icd	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	IDH
k59_941114_1	1304872.JAGC01000005_gene1868	1.22e-34	127.0	COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,42PKF@68525|delta/epsilon subdivisions,2WNQ4@28221|Deltaproteobacteria,2M86K@213115|Desulfovibrionales	28221|Deltaproteobacteria	U	PFAM MotA TolQ ExbB proton channel	tolQ	-	-	ko:K03561,ko:K03562	ko01120,map01120	-	-	-	ko00000,ko02000	1.A.30.2.1,1.A.30.2.2	-	-	MotA_ExbB
k59_827000_1	1121939.L861_10420	1.57e-83	259.0	COG2017@1|root,COG2017@2|Bacteria,1MVMN@1224|Proteobacteria,1RNZN@1236|Gammaproteobacteria,1XJKW@135619|Oceanospirillales	135619|Oceanospirillales	G	Converts alpha-aldose to the beta-anomer	galM	-	5.1.3.3	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	M00632	R01602,R10619	RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldose_epim
k59_883038_1	1133850.SHJG_5892	8.02e-05	47.4	COG1983@1|root,COG1983@2|Bacteria,2GIVS@201174|Actinobacteria	201174|Actinobacteria	KT	PspC domain protein	pspC	-	-	-	-	-	-	-	-	-	-	-	DUF2154,PspC
k59_1329986_1	880073.Calab_1368	5.77e-111	338.0	COG0465@1|root,COG0465@2|Bacteria,2NNQ5@2323|unclassified Bacteria	2|Bacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	GO:0000166,GO:0003674,GO:0003824,GO:0004175,GO:0004176,GO:0004222,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009056,GO:0009057,GO:0010468,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019222,GO:0019538,GO:0030145,GO:0030163,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043273,GO:0044238,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_159762_2	402881.Plav_2952	2.08e-13	69.7	COG0846@1|root,COG0846@2|Bacteria,1MUK1@1224|Proteobacteria,2TV1Q@28211|Alphaproteobacteria,1JNTA@119043|Rhodobiaceae	28211|Alphaproteobacteria	K	Sir2 family	MA20_30275	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
k59_1105769_1	797299.HALLA_08745	1.81e-58	191.0	COG0212@1|root,arCOG00474@2157|Archaea,2XTN7@28890|Euryarchaeota,23S39@183963|Halobacteria	183963|Halobacteria	H	5-formyltetrahydrofolate cycloligase	-	-	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
k59_496388_1	997350.HMPREF9129_1215	6.98e-48	173.0	COG0495@1|root,COG0495@2|Bacteria,1TP0Y@1239|Firmicutes,2484Y@186801|Clostridia,22GEM@1570339|Peptoniphilaceae	186801|Clostridia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
k59_1215747_1	926560.KE387027_gene845	2.96e-09	56.2	COG1051@1|root,COG1051@2|Bacteria,1WN7A@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
k59_1438688_1	1382359.JIAL01000001_gene680	9.22e-56	189.0	COG0719@1|root,COG0719@2|Bacteria,3Y4EK@57723|Acidobacteria	57723|Acidobacteria	O	Uncharacterized protein family (UPF0051)	-	-	-	ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
k59_883076_1	1064537.AGSO01000006_gene1857	1.14e-13	70.5	COG0446@1|root,COG0446@2|Bacteria,2GJKT@201174|Actinobacteria,4FDIP@85020|Dermabacteraceae	201174|Actinobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	AIF_C,Pyr_redox_2
k59_1659652_1	1120960.ATXG01000013_gene3419	2.76e-25	99.4	COG0572@1|root,COG0572@2|Bacteria,2I69G@201174|Actinobacteria,4FTPF@85023|Microbacteriaceae	201174|Actinobacteria	F	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
k59_1659652_2	649831.L083_0846	3.64e-12	68.2	COG0421@1|root,COG0421@2|Bacteria,2GN8I@201174|Actinobacteria,4DME6@85008|Micromonosporales	201174|Actinobacteria	E	spermidine synthase	speE	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11
k59_1050992_1	998674.ATTE01000001_gene2708	1.08e-56	186.0	COG0777@1|root,COG0777@2|Bacteria,1MW8G@1224|Proteobacteria,1RNDS@1236|Gammaproteobacteria,4600U@72273|Thiotrichales	72273|Thiotrichales	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	-	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_268901_1	1283283.ATXA01000006_gene1844	2.61e-58	193.0	COG3384@1|root,COG3384@2|Bacteria,2GJDG@201174|Actinobacteria	201174|Actinobacteria	S	PFAM Extradiol ring-cleavage dioxygenase, class III enzyme, subunit B	-	-	-	-	-	-	-	-	-	-	-	-	LigB
k59_383022_1	326427.Cagg_0119	1.14e-79	247.0	COG1087@1|root,COG1087@2|Bacteria,2G5QM@200795|Chloroflexi,3754S@32061|Chloroflexia	32061|Chloroflexia	M	Belongs to the NAD(P)-dependent epimerase dehydratase family	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
k59_548673_1	1165841.SULAR_10409	5.99e-24	98.6	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,42MWZ@68525|delta/epsilon subdivisions,2YMZW@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
k59_1547777_1	1500259.JQLD01000002_gene3008	3.89e-10	67.0	COG2202@1|root,COG2982@1|root,COG3209@1|root,COG3210@1|root,COG5295@1|root,COG2202@2|Bacteria,COG2982@2|Bacteria,COG3209@2|Bacteria,COG3210@2|Bacteria,COG5295@2|Bacteria,1QUXB@1224|Proteobacteria,2TWTY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	U	PFAM SMP-30 Gluconolaconase	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,DUF4347
k59_548696_1	3880.AES83108	4.99e-77	258.0	COG0466@1|root,KOG2004@2759|Eukaryota,37QRW@33090|Viridiplantae,3GCYG@35493|Streptophyta,4JJKB@91835|fabids	35493|Streptophyta	O	ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import	-	-	-	-	-	-	-	-	-	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_1438753_1	1354722.JQLS01000008_gene2021	2.73e-59	194.0	COG0079@1|root,COG0079@2|Bacteria,1MWPU@1224|Proteobacteria,2TRV5@28211|Alphaproteobacteria,46NKV@74030|Roseovarius	28211|Alphaproteobacteria	E	COG0079 Histidinol-phosphate aromatic aminotransferase and cobyric acid decarboxylase	hisC1	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_437643_2	485913.Krac_8652	4.77e-07	52.8	COG0275@1|root,COG0275@2|Bacteria,2G658@200795|Chloroflexi	200795|Chloroflexi	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
k59_770306_1	443144.GM21_1283	1.66e-62	221.0	COG0834@1|root,COG4191@1|root,COG0834@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4,PocR,Response_reg,SBP_bac_3
k59_329011_1	1380367.JIBC01000016_gene1106	1.58e-10	63.2	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TVI3@28211|Alphaproteobacteria,3ZWMD@60136|Sulfitobacter	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	-	-	-	-	-	-	-	-	-	TctA
k59_329011_2	566466.NOR53_2956	5.42e-34	125.0	COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,1RRPI@1236|Gammaproteobacteria,1J80Z@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	CE COG0473 Isocitrate isopropylmalate dehydrogenase	yeaU	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003862,GO:0005488,GO:0006082,GO:0006108,GO:0008150,GO:0008152,GO:0009027,GO:0009987,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0019752,GO:0036094,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044281,GO:0046553,GO:0046872,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363	1.1.1.83,1.1.1.93,4.1.1.73	ko:K07246	ko00630,ko00650,map00630,map00650	-	R00215,R01751,R02545,R06180	RC00084,RC00105,RC00594	ko00000,ko00001,ko01000	-	-	iSBO_1134.SBO_1288	Iso_dh
k59_602996_1	765420.OSCT_3226	4.56e-12	70.9	COG1630@1|root,COG1630@2|Bacteria,2G68Z@200795|Chloroflexi,374ZP@32061|Chloroflexia	32061|Chloroflexia	S	NurA	-	-	-	-	-	-	-	-	-	-	-	-	NurA
k59_548716_2	373994.Riv7116_1490	1.57e-14	73.9	COG4747@1|root,COG4747@2|Bacteria,1GEKW@1117|Cyanobacteria	1117|Cyanobacteria	S	ACT domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_657804_1	926569.ANT_30000	1.59e-15	77.0	COG1193@1|root,COG1193@2|Bacteria,2G5R8@200795|Chloroflexi	200795|Chloroflexi	L	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_III,MutS_V,Smr
k59_657804_2	710687.KI912270_gene6264	2.21e-05	48.5	COG4222@1|root,COG4222@2|Bacteria,2GNHR@201174|Actinobacteria,234JP@1762|Mycobacteriaceae	201174|Actinobacteria	S	Esterase-like activity of phytase	-	-	3.1.3.8	ko:K01083	ko00562,map00562	-	R03371	RC00078	ko00000,ko00001,ko01000	-	-	-	Phytase-like
k59_603015_1	1123255.JHYS01000002_gene2601	1.43e-26	110.0	COG0126@1|root,COG0126@2|Bacteria,1MUNU@1224|Proteobacteria,2VHJK@28216|Betaproteobacteria,4AB3S@80864|Comamonadaceae	28216|Betaproteobacteria	F	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
k59_883193_1	289377.HL41_02840	7.59e-33	125.0	COG0223@1|root,COG0223@2|Bacteria,2GGW2@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
k59_496490_1	1120950.KB892770_gene1390	6.6e-10	65.9	COG0044@1|root,COG0044@2|Bacteria,2GK4A@201174|Actinobacteria,4DP6H@85009|Propionibacteriales	201174|Actinobacteria	F	Amidohydrolase family	hydA	-	3.5.2.2	ko:K01464	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R02269,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Amidohydro_1
k59_1547854_1	1379270.AUXF01000007_gene936	3.9e-56	203.0	COG1629@1|root,COG4771@2|Bacteria,1ZUKQ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	P	Outer membrane protein beta-barrel family	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
k59_1717803_1	1089546.AQUI01000002_gene501	3.8e-07	52.0	COG0494@1|root,COG0494@2|Bacteria,2GN6D@201174|Actinobacteria,407I6@622450|Actinopolysporales	201174|Actinobacteria	L	NUDIX hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
k59_1717803_2	331869.BAL199_23774	5.92e-12	68.9	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,2TRW2@28211|Alphaproteobacteria,4BPF3@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_S41
k59_1547857_1	394221.Mmar10_0175	7.39e-59	187.0	COG3316@1|root,COG3316@2|Bacteria,1P9SM@1224|Proteobacteria,2TV17@28211|Alphaproteobacteria,43XZD@69657|Hyphomonadaceae	28211|Alphaproteobacteria	L	COG3316 Transposase and inactivated derivatives	-	-	-	ko:K07498	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS240
k59_268980_1	504728.K649_06125	1.32e-37	138.0	COG0077@1|root,COG0077@2|Bacteria,1WIGR@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Prephenate dehydratase	pheA	-	4.2.1.51,5.4.99.5	ko:K04518,ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R00691,R01373,R01715	RC00360,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PDT
k59_437700_1	608538.HTH_1717	1.25e-199	586.0	COG0243@1|root,COG0243@2|Bacteria,2G51K@200783|Aquificae	200783|Aquificae	C	Molybdopterin oxidoreductase	-	-	1.7.5.1	ko:K00370,ko:K17050	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000,ko02000	5.A.3.1,5.A.3.8	-	-	Molybdopterin,Molydop_binding
k59_1275500_1	208439.AJAP_29540	3.25e-58	189.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4E0JW@85010|Pseudonocardiales	201174|Actinobacteria	V	ABC transporter	nodI	-	-	ko:K09695	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC_tran
k59_1275500_2	35754.JNYJ01000086_gene2318	6.38e-12	65.9	COG0842@1|root,COG0842@2|Bacteria,2GVC2@201174|Actinobacteria	201174|Actinobacteria	V	transport, permease protein	-	-	-	ko:K09694	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC2_membrane
k59_1547866_1	330214.NIDE1362	0.000562	48.1	COG2844@1|root,COG2844@2|Bacteria	2|Bacteria	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	-	2.7.7.42,2.7.7.59,2.7.7.89	ko:K00982,ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,GlnD_UR_UTase,HD,NTP_transf_2
k59_268988_1	2340.JV46_03320	1.87e-16	77.8	COG2826@1|root,COG2826@2|Bacteria,1MWI0@1224|Proteobacteria,1RRSE@1236|Gammaproteobacteria,1J63G@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	IS30 family	ISPlu1B	-	-	ko:K07482	-	-	-	-	ko00000	-	-	-	HTH_38,rve
k59_268988_2	751945.Theos_1027	2.38e-35	134.0	COG2202@1|root,COG3437@1|root,COG3829@1|root,COG2202@2|Bacteria,COG3437@2|Bacteria,COG3829@2|Bacteria,1WJ3D@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	PFAM HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HD,HD_5,PAS,PAS_3,PAS_4,PAS_9
k59_212722_1	1307759.JOMJ01000003_gene222	1.37e-33	130.0	COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,42N9E@68525|delta/epsilon subdivisions,2WJAX@28221|Deltaproteobacteria,2M7YX@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	ko:K22226	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
k59_1771151_1	326427.Cagg_1684	3.33e-16	77.8	COG1668@1|root,COG1668@2|Bacteria,2G9RA@200795|Chloroflexi	200795|Chloroflexi	CP	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
k59_1771151_2	313612.L8106_01722	5.34e-06	51.6	COG1131@1|root,COG1131@2|Bacteria,1G11U@1117|Cyanobacteria,1H8ET@1150|Oscillatoriales	1117|Cyanobacteria	V	ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_603041_1	684949.ATTJ01000002_gene264	4.78e-29	115.0	COG0428@1|root,COG0428@2|Bacteria,1WM75@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	transporter	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_603041_2	1203550.HMPREF1475_00811	7.13e-22	93.2	COG1956@1|root,COG1956@2|Bacteria,4NM6D@976|Bacteroidetes,2FS26@200643|Bacteroidia	976|Bacteroidetes	T	GAF domain-containing protein	msrC	-	1.8.4.14	ko:K08968	ko00270,map00270	-	R02025	RC00639	ko00000,ko00001,ko01000	-	-	-	GAF,GAF_2
k59_604913_1	997296.PB1_08712	5.99e-21	96.7	COG1529@1|root,COG1529@2|Bacteria,1TP7U@1239|Firmicutes,4HC1W@91061|Bacilli,1ZC08@1386|Bacillus	91061|Bacilli	C	COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL homologs	pucD	-	1.17.1.4	ko:K00087	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU32480	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2
k59_720729_1	1459636.NTE_00007	9.73e-47	170.0	COG0417@1|root,arCOG00329@2157|Archaea	2157|Archaea	L	DNA polymerase elongation subunit (Family B)	polB2	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B
k59_1661723_1	319225.Plut_0520	1.43e-22	99.0	COG4232@1|root,COG4232@2|Bacteria	2|Bacteria	CO	protein-disulfide reductase activity	dsbD	GO:0003674,GO:0003756,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0008152,GO:0009266,GO:0009628,GO:0009898,GO:0009987,GO:0015035,GO:0015036,GO:0016020,GO:0016021,GO:0016043,GO:0016491,GO:0016667,GO:0016853,GO:0016860,GO:0016864,GO:0017004,GO:0019725,GO:0022607,GO:0031224,GO:0031226,GO:0034622,GO:0042221,GO:0042493,GO:0042592,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0045454,GO:0050789,GO:0050794,GO:0050896,GO:0055114,GO:0065003,GO:0065007,GO:0065008,GO:0071502,GO:0071840,GO:0071944,GO:0098552,GO:0098562,GO:0140096	1.8.1.8	ko:K04084	-	-	-	-	ko00000,ko01000,ko03110	5.A.1.1	-	iECSE_1348.ECSE_4435	DsbC,DsbD,Thioredoxin,Thioredoxin_2,Thioredoxin_7
k59_49971_1	795359.TOPB45_0241	1.75e-31	126.0	COG0475@1|root,COG0490@1|root,COG1226@1|root,COG0475@2|Bacteria,COG0490@2|Bacteria,COG1226@2|Bacteria,2GHHX@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	P	Sodium/hydrogen exchanger family	-	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger,TrkA_C,TrkA_N
k59_49973_1	1121939.L861_18905	1.29e-22	93.2	COG1628@1|root,COG1628@2|Bacteria,1RCX1@1224|Proteobacteria,1S7VS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function DUF99	-	-	-	ko:K09120	-	-	-	-	ko00000	-	-	-	DUF99
k59_1053727_1	996637.SGM_5725	5.16e-118	350.0	COG0714@1|root,COG0714@2|Bacteria,2GK07@201174|Actinobacteria	201174|Actinobacteria	S	associated with various cellular activities	yeaC	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
k59_1549852_1	349521.HCH_06318	3.1e-100	303.0	COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,1RMVU@1236|Gammaproteobacteria,1XIWQ@135619|Oceanospirillales	135619|Oceanospirillales	C	alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Fe-ADH
k59_1773861_1	1136417.AZWE01000003_gene3380	1.96e-34	131.0	COG0477@1|root,COG0477@2|Bacteria,2I377@201174|Actinobacteria,4DMPE@85008|Micromonosporales	201174|Actinobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1773861_2	1306990.BARG01000022_gene2195	7.33e-05	46.6	COG0640@1|root,COG0640@2|Bacteria,2II9U@201174|Actinobacteria	201174|Actinobacteria	K	regulatory protein, arsR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
k59_1217734_1	208444.JNYY01000009_gene3526	6.33e-17	84.7	COG0683@1|root,COG0683@2|Bacteria,2GMCF@201174|Actinobacteria,4DXT7@85010|Pseudonocardiales	201174|Actinobacteria	E	Periplasmic binding protein	bra	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
k59_498988_1	1380394.JADL01000002_gene1565	4.8e-84	266.0	COG0642@1|root,COG0642@2|Bacteria,1QU3Y@1224|Proteobacteria,2TVYH@28211|Alphaproteobacteria,2JYYW@204441|Rhodospirillales	204441|Rhodospirillales	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
k59_498988_2	414684.RC1_2542	6.07e-85	255.0	COG4567@1|root,COG4567@2|Bacteria,1RD7J@1224|Proteobacteria,2TSK7@28211|Alphaproteobacteria,2JRWP@204441|Rhodospirillales	204441|Rhodospirillales	T	Bacterial regulatory protein, Fis family	regA	-	-	ko:K15012	ko02020,map02020	M00523	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg
k59_783299_1	1121405.dsmv_2306	2.63e-124	377.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,42M4Z@68525|delta/epsilon subdivisions,2WJZ3@28221|Deltaproteobacteria,2MN0D@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Peptidase family M41	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_1117149_1	1249627.D779_1947	1.24e-63	209.0	COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,1RQ0H@1236|Gammaproteobacteria,1WWQC@135613|Chromatiales	135613|Chromatiales	E	TIGRFAM Threonine synthase	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_synth_N
k59_1672867_1	1123487.KB892834_gene2905	9.06e-06	45.1	COG0346@1|root,COG0346@2|Bacteria,1RCYX@1224|Proteobacteria,2VR7R@28216|Betaproteobacteria,2KWC1@206389|Rhodocyclales	206389|Rhodocyclales	E	Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
k59_1672867_2	95619.PM1_0208010	1.2e-95	290.0	COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,1RMEC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Belongs to the argininosuccinate synthase family. Type	argG	GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
k59_616461_1	1122605.KB893637_gene3149	1.35e-14	77.8	COG1131@1|root,COG1131@2|Bacteria,4NFW9@976|Bacteroidetes,1IQRB@117747|Sphingobacteriia	976|Bacteroidetes	V	PFAM ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1394766_1	479434.Sthe_2017	3.15e-14	70.9	COG1968@1|root,COG1968@2|Bacteria,2G6F7@200795|Chloroflexi,27Y0J@189775|Thermomicrobia	189775|Thermomicrobia	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
k59_1394766_2	671143.DAMO_0473	4.42e-23	97.4	COG1028@1|root,COG1028@2|Bacteria,2NPQY@2323|unclassified Bacteria	2|Bacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_449926_1	991905.SL003B_1053	7.88e-41	153.0	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2TQY9@28211|Alphaproteobacteria,4BR6A@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	TRAP transporter, 4TM 12TM fusion protein	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_1117155_2	656024.FsymDg_3050	2.04e-34	131.0	COG1233@1|root,COG1233@2|Bacteria,2GP0A@201174|Actinobacteria	201174|Actinobacteria	Q	Flavin containing amine oxidoreductase	-	-	5.2.1.13	ko:K09835	ko00906,ko01100,ko01110,map00906,map01100,map01110	M00097	R07512	RC01960	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
k59_783328_1	420324.KI911965_gene757	2.42e-85	276.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2TTBF@28211|Alphaproteobacteria,1JTJZ@119045|Methylobacteriaceae	28211|Alphaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015627,GO:0015628,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:0098776,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_283138_1	1123023.JIAI01000007_gene1963	7.74e-85	281.0	COG0404@1|root,COG0446@1|root,COG4583@1|root,COG0404@2|Bacteria,COG0446@2|Bacteria,COG4583@2|Bacteria,2GMBK@201174|Actinobacteria,4E081@85010|Pseudonocardiales	201174|Actinobacteria	E	Belongs to the GcvT family	-	-	1.5.3.1	ko:K00302	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	FAD_oxidored,Fer2_4,GCV_T,GCV_T_C,Pyr_redox_2
k59_1561618_1	996637.SGM_5515	3.02e-39	145.0	COG0306@1|root,COG0306@2|Bacteria,2GJHK@201174|Actinobacteria	201174|Actinobacteria	P	phosphate transporter	pitA	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
k59_1561618_2	641107.CDLVIII_3684	2.96e-12	64.7	COG1392@1|root,COG1392@2|Bacteria,1UYRI@1239|Firmicutes,24BCU@186801|Clostridia,36DGM@31979|Clostridiaceae	186801|Clostridia	P	phosphate transport regulator	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
k59_1005859_1	1173029.JH980292_gene904	2.51e-05	51.6	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,1FZWQ@1117|Cyanobacteria,1H6WA@1150|Oscillatoriales	1117|Cyanobacteria	KLT	PFAM Protein kinase domain	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_1,TPR_11,TPR_16,TPR_2,TPR_6,TPR_8
k59_1450697_2	420247.Msm_0559	4.18e-52	179.0	COG0674@1|root,arCOG01608@2157|Archaea,2XTB0@28890|Euryarchaeota,23NRM@183925|Methanobacteria	183925|Methanobacteria	C	ferredoxin oxidoreductase	porA	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
k59_1172463_1	1123250.KB908379_gene1020	5.58e-36	139.0	COG0608@1|root,COG0608@2|Bacteria,1TPXE@1239|Firmicutes,4H201@909932|Negativicutes	909932|Negativicutes	L	single-stranded-DNA-specific exonuclease RecJ	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
k59_449951_1	426114.THI_1811	1.83e-08	52.8	COG0236@1|root,COG0236@2|Bacteria,1NC80@1224|Proteobacteria	1224|Proteobacteria	IQ	Acyl carrier protein	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
k59_1617117_1	1108045.GORHZ_143_00030	3.5e-19	82.4	COG0640@1|root,COG0640@2|Bacteria,2IKPW@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator, arsR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
k59_1617117_2	710696.Intca_2822	2.85e-12	65.1	COG2210@1|root,COG2210@2|Bacteria,2IGW8@201174|Actinobacteria	201174|Actinobacteria	S	DsrE/DsrF/DrsH-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2
k59_1339332_1	269799.Gmet_1812	2.28e-64	211.0	COG5557@1|root,COG5557@2|Bacteria,1PFX4@1224|Proteobacteria,42PIE@68525|delta/epsilon subdivisions,2WM3C@28221|Deltaproteobacteria,43SBI@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Polysulphide reductase, NrfD	moz	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	DUF3341,NrfD
k59_1450715_1	402626.Rpic_2570	4.48e-22	100.0	COG1587@1|root,COG2959@1|root,COG1587@2|Bacteria,COG2959@2|Bacteria,1MWZD@1224|Proteobacteria,2VT8N@28216|Betaproteobacteria,1KGXK@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Uroporphyrinogen-III synthase HemD	hemD	-	2.1.1.107,4.2.1.75	ko:K01719,ko:K13543	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165,R03194	RC00003,RC00871,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4,HemX
k59_283162_1	487316.BBNM01000004_gene531	8.19e-13	69.3	COG1080@1|root,COG1925@1|root,COG1080@2|Bacteria,COG1925@2|Bacteria,1MUT8@1224|Proteobacteria,1RN6R@1236|Gammaproteobacteria,3NMAE@468|Moraxellaceae	1236|Gammaproteobacteria	G	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2	fruB	-	2.7.1.202,2.7.3.9	ko:K02768,ko:K08483,ko:K11183,ko:K11189	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1,8.A.7	-	-	EIIA-man,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C,PTS-HPr,PTS_EIIA_2
k59_283162_2	177437.HRM2_08660	4.32e-32	124.0	COG1063@1|root,COG1063@2|Bacteria,1QA80@1224|Proteobacteria	1224|Proteobacteria	E	L-sorbose 1-phosphate reductase	-	-	-	ko:K19956	ko00051,map00051	-	R03234	RC00089	ko00000,ko00001,ko01000	-	-	-	ADH_N
k59_1228640_1	331869.BAL199_06164	5.01e-86	275.0	COG0477@1|root,COG2814@2|Bacteria,1MUDA@1224|Proteobacteria,2TS0P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1617143_1	617140.AJZE01000020_gene1523	2.45e-05	51.2	COG0671@1|root,COG0671@2|Bacteria,1RJ1T@1224|Proteobacteria,1SAU1@1236|Gammaproteobacteria,1XWVF@135623|Vibrionales	135623|Vibrionales	I	COG0671 Membrane-associated phospholipid phosphatase	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
k59_894785_1	1116472.MGMO_41c00400	2.45e-22	89.0	COG0292@1|root,COG0292@2|Bacteria,1RGU2@1224|Proteobacteria,1S3P3@1236|Gammaproteobacteria,1XF6T@135618|Methylococcales	135618|Methylococcales	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	-	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
k59_894785_2	391615.ABSJ01000059_gene2182	2.89e-17	76.3	COG0291@1|root,COG0291@2|Bacteria	2|Bacteria	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
k59_728008_1	189753.AXAS01000006_gene2442	2.85e-59	201.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,3JR8W@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Adenylate cyclase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,TPR_8,TolB_N
k59_783386_1	309807.SRU_0716	6.12e-28	107.0	COG0629@1|root,COG0629@2|Bacteria,4NQBK@976|Bacteroidetes,1FJER@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
k59_1450756_1	1382306.JNIM01000001_gene139	3.97e-57	194.0	COG1160@1|root,COG1160@2|Bacteria,2G5M0@200795|Chloroflexi	200795|Chloroflexi	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
k59_60724_2	928724.SacglDRAFT_03631	1.36e-49	174.0	COG3525@1|root,COG3525@2|Bacteria,2H28J@201174|Actinobacteria,4DYKQ@85010|Pseudonocardiales	201174|Actinobacteria	G	Glycosyl hydrolase family 20, domain 2	hexA	-	3.2.1.52	ko:K12373	ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142	M00079	R00022,R06004,R11316	RC00049	ko00000,ko00001,ko00002,ko01000,ko03110	-	GH20	-	Glyco_hydro_20,Glyco_hydro_20b
k59_1506057_1	1123256.KB907926_gene797	1.28e-14	71.6	COG3151@1|root,COG3151@2|Bacteria,1MYG8@1224|Proteobacteria,1S7P6@1236|Gammaproteobacteria,1X7UD@135614|Xanthomonadales	135614|Xanthomonadales	S	Protein of unknown function (DUF1249)	-	-	-	ko:K09920	-	-	-	-	ko00000	-	-	-	DUF1249
k59_1172535_1	861299.J421_3747	1.35e-10	67.0	COG1197@1|root,COG1197@2|Bacteria,1ZT88@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_838877_1	566461.SSFG_02883	5.15e-07	58.5	COG2267@1|root,COG2267@2|Bacteria,2GMCK@201174|Actinobacteria	201174|Actinobacteria	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
k59_505558_1	1121930.AQXG01000018_gene756	1.42e-65	226.0	COG1506@1|root,COG1506@2|Bacteria,4NDVD@976|Bacteroidetes,1IR4H@117747|Sphingobacteriia	976|Bacteroidetes	E	peptidase S9 prolyl oligopeptidase active site domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9
k59_338472_1	383372.Rcas_1934	1.79e-68	228.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,2G7MP@200795|Chloroflexi,3760K@32061|Chloroflexia	32061|Chloroflexia	C	PFAM NADH flavin oxidoreductase NADH oxidase	-	-	1.5.8.1,1.5.8.2	ko:K00317	ko00680,ko01120,ko01200,map00680,map01120,map01200	-	R01588,R02511	RC00185,RC00556,RC00557,RC00732	ko00000,ko00001,ko01000	-	-	-	Oxidored_FMN,Pyr_redox_2
k59_1506082_2	643867.Ftrac_3675	1.23e-40	142.0	29KMP@1|root,307IZ@2|Bacteria,4PQ15@976|Bacteroidetes,47YT5@768503|Cytophagia	976|Bacteroidetes	S	Domain of unknown function (DUF4287)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4287
k59_1061329_1	1461580.CCAS010000001_gene89	6.23e-34	129.0	COG2423@1|root,COG2423@2|Bacteria,1TPHM@1239|Firmicutes,4HCUU@91061|Bacilli,1ZR18@1386|Bacillus	91061|Bacilli	E	Ornithine cyclodeaminase/mu-crystallin family	-	-	4.3.1.12	ko:K01750	ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230	-	R00671	RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
k59_283248_2	1034345.CAEM01000033_gene78	2.29e-23	102.0	COG0086@1|root,COG0086@2|Bacteria,2GKWF@201174|Actinobacteria,4CUED@84998|Coriobacteriia	84998|Coriobacteriia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_1172577_1	56107.Cylst_2409	2.35e-32	130.0	COG1529@1|root,COG2080@1|root,COG1529@2|Bacteria,COG2080@2|Bacteria,1G35M@1117|Cyanobacteria,1HISS@1161|Nostocales	1117|Cyanobacteria	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	1.17.1.4	ko:K11177	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2
k59_1506120_1	518766.Rmar_0089	1.82e-66	226.0	COG0612@1|root,COG0612@2|Bacteria,4NEDZ@976|Bacteroidetes,1FIP6@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Peptidase M16	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_450077_1	243230.DR_A0069	2.73e-19	92.0	COG1236@1|root,COG1236@2|Bacteria,1WISK@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	J	exonuclease of the beta-lactamase fold involved in RNA processing	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,RMMBL
k59_450085_1	671143.DAMO_2345	1.59e-53	177.0	COG0451@1|root,COG0451@2|Bacteria,2NNT0@2323|unclassified Bacteria	2|Bacteria	M	Polysaccharide biosynthesis protein	lspL	-	5.1.3.6	ko:K08679	ko00520,ko01100,map00520,map01100	-	R01385	RC00289	ko00000,ko00001,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
k59_1617245_1	313603.FB2170_15633	5.43e-69	224.0	COG1680@1|root,COG1680@2|Bacteria,4NFUI@976|Bacteroidetes,1HWMZ@117743|Flavobacteriia	976|Bacteroidetes	V	beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_1228785_1	671143.DAMO_2814	6.65e-71	219.0	COG0634@1|root,COG0634@2|Bacteria,2NPER@2323|unclassified Bacteria	2|Bacteria	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	hpt	GO:0000287,GO:0003674,GO:0003824,GO:0004422,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006166,GO:0006177,GO:0006188,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032261,GO:0032263,GO:0032264,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0043094,GO:0043101,GO:0043167,GO:0043169,GO:0043173,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046040,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
k59_783469_1	485913.Krac_8280	1.55e-46	166.0	COG1007@1|root,COG1007@2|Bacteria,2G5ZK@200795|Chloroflexi	200795|Chloroflexi	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
k59_950368_1	1173025.GEI7407_2986	1e-44	166.0	COG2114@1|root,COG2202@1|root,COG3605@1|root,COG3850@1|root,COG2114@2|Bacteria,COG2202@2|Bacteria,COG3605@2|Bacteria,COG3850@2|Bacteria,1FZXP@1117|Cyanobacteria,1H71W@1150|Oscillatoriales	1117|Cyanobacteria	T	Belongs to the adenylyl cyclase class-4 guanylyl cyclase family	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,PAS_9,Response_reg
k59_672464_1	379066.GAU_0638	2.95e-62	207.0	COG0745@1|root,COG0745@2|Bacteria,1ZTEW@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KT	PglZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PglZ,Response_reg
k59_840589_1	457570.Nther_1199	1.14e-64	221.0	COG1480@1|root,COG1480@2|Bacteria,1TR1A@1239|Firmicutes,249W0@186801|Clostridia	186801|Clostridia	O	metal-dependent phosphohydrolase 7TM intracellular region	-	-	-	ko:K07037	-	-	-	-	ko00000	-	-	-	7TM-7TMR_HD,7TMR-HDED,HD
k59_451845_1	1122603.ATVI01000007_gene1680	3.65e-84	265.0	COG0519@1|root,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,1RP81@1236|Gammaproteobacteria,1X2YI@135614|Xanthomonadales	135614|Xanthomonadales	F	Catalyzes the synthesis of GMP from XMP	guaA	GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
k59_62483_1	1379270.AUXF01000003_gene3803	3.42e-06	48.5	COG1228@1|root,COG1228@2|Bacteria,1ZSU7@142182|Gemmatimonadetes	142182|Gemmatimonadetes	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_62483_2	1198452.Jab_2c14800	4.12e-25	106.0	COG0308@1|root,COG0308@2|Bacteria,1MUV3@1224|Proteobacteria,2W2NZ@28216|Betaproteobacteria,476FA@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Peptidase family M1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
k59_229405_1	553175.POREN0001_0713	2.69e-19	87.4	COG0606@1|root,COG0606@2|Bacteria,4NE0G@976|Bacteroidetes,2FMHE@200643|Bacteroidia,22W0Y@171551|Porphyromonadaceae	976|Bacteroidetes	O	magnesium chelatase	comM	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
k59_562617_1	926569.ANT_27410	1.81e-57	201.0	COG0525@1|root,COG0525@2|Bacteria,2G5VS@200795|Chloroflexi	200795|Chloroflexi	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
k59_952092_1	1192034.CAP_3887	3.5e-80	261.0	COG0654@1|root,COG1902@1|root,COG0654@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,42PDA@68525|delta/epsilon subdivisions,2WK05@28221|Deltaproteobacteria,2YZMG@29|Myxococcales	28221|Deltaproteobacteria	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	1.14.13.40	ko:K09461	ko00627,ko01120,map00627,map01120	-	R03998,R03999	RC00244	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3,Oxidored_FMN
k59_1618917_1	944481.JAFP01000001_gene1493	1.55e-121	358.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,42MWZ@68525|delta/epsilon subdivisions,2WJ2B@28221|Deltaproteobacteria,2M6A0@213113|Desulfurellales	28221|Deltaproteobacteria	J	GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
k59_729911_1	1449976.KALB_3177	7.5e-10	64.7	COG5002@1|root,COG5002@2|Bacteria,2GIX7@201174|Actinobacteria,4E0BU@85010|Pseudonocardiales	201174|Actinobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K07642	ko02020,map02020	M00450,M00645,M00646,M00648	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
k59_674231_1	394.NGR_c05110	1.48e-17	82.4	COG1861@1|root,COG1861@2|Bacteria,1QU5J@1224|Proteobacteria,2U0ZH@28211|Alphaproteobacteria,4BJ1H@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Transposase DDE domain group 1	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k59_674231_2	1197477.IA57_04370	0.000176	44.3	2E1SY@1|root,32X2R@2|Bacteria,4P2JP@976|Bacteroidetes,1I8M6@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_729916_1	883126.HMPREF9710_01964	7.23e-21	96.7	COG0793@1|root,COG0793@2|Bacteria	2|Bacteria	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S41,Tricorn_C1
k59_674239_1	269796.Rru_A2695	2.55e-38	142.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,2TS7S@28211|Alphaproteobacteria,2JQ0Q@204441|Rhodospirillales	204441|Rhodospirillales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_674239_2	570967.JMLV01000022_gene2093	8.19e-45	160.0	COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,2TRHV@28211|Alphaproteobacteria,2JQ0E@204441|Rhodospirillales	204441|Rhodospirillales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_562642_1	861299.J421_1667	1.08e-16	85.1	COG0577@1|root,COG0577@2|Bacteria	861299.J421_1667|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1230760_2	331869.BAL199_12236	1.22e-28	112.0	COG4948@1|root,COG4948@2|Bacteria,1MW5B@1224|Proteobacteria,2UNXP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Belongs to the mandelate racemase muconate lactonizing enzyme family	MA20_01265	-	4.2.1.6	ko:K01684	ko00052,ko01100,ko01120,map00052,map01100,map01120	M00552	R03033	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
k59_674246_1	589865.DaAHT2_1482	1.45e-22	97.8	COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,42MJY@68525|delta/epsilon subdivisions,2WJAQ@28221|Deltaproteobacteria,2MHTV@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	AlaDh_PNT_C,FAD_binding_3,Mur_ligase_C,Mur_ligase_M,NAD_binding_8
k59_674246_2	273068.TTE1646	1.24e-10	62.8	COG0772@1|root,COG0772@2|Bacteria,1TPT7@1239|Firmicutes,24894@186801|Clostridia,42EPV@68295|Thermoanaerobacterales	186801|Clostridia	D	Belongs to the SEDS family	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
k59_451884_1	311403.Arad_7616	8.69e-39	144.0	COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,2TREV@28211|Alphaproteobacteria,4B7FQ@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	udg	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
k59_1730283_1	926569.ANT_19480	9.29e-137	410.0	COG1138@1|root,COG1138@2|Bacteria,2G5SZ@200795|Chloroflexi	200795|Chloroflexi	O	PFAM Cytochrome C assembly protein	ccmF	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
k59_785247_1	518766.Rmar_1178	5.93e-48	172.0	COG3591@1|root,COG3591@2|Bacteria,4NEAK@976|Bacteroidetes,1FJT8@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	E	Peptidase S46	dpp7	GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005575,GO:0005576,GO:0005623,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008239,GO:0009056,GO:0009279,GO:0009986,GO:0009987,GO:0016020,GO:0016049,GO:0016787,GO:0017171,GO:0019538,GO:0019867,GO:0030154,GO:0030312,GO:0030313,GO:0031975,GO:0032502,GO:0033218,GO:0034641,GO:0040007,GO:0042277,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044462,GO:0044464,GO:0048468,GO:0048588,GO:0048589,GO:0048856,GO:0048869,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575	-	-	-	-	-	-	-	-	-	-	Peptidase_S46
k59_7157_1	1380347.JNII01000006_gene1815	2.51e-24	104.0	COG4585@1|root,COG4585@2|Bacteria,2HDZV@201174|Actinobacteria,4EX5G@85013|Frankiales	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_3
k59_123748_1	443143.GM18_4037	1.84e-48	176.0	COG1361@1|root,COG4932@1|root,COG1361@2|Bacteria,COG4932@2|Bacteria,1R5G4@1224|Proteobacteria,42T0V@68525|delta/epsilon subdivisions,2WPRT@28221|Deltaproteobacteria,43TPS@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Domain of unknown function DUF11	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,SdrD_B
k59_846465_1	1038859.AXAU01000003_gene6186	6.85e-79	254.0	COG0577@1|root,COG1136@1|root,COG0577@2|Bacteria,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,2TS3W@28211|Alphaproteobacteria,3JTIG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	V	Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides	-	-	-	ko:K02003,ko:K05685	ko02010,map02010	M00258,M00709	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.122.1,3.A.1.122.12	-	-	ABC_tran,FtsX,MacB_PCD
k59_458195_1	452863.Achl_0457	1.41e-28	118.0	COG1082@1|root,COG1082@2|Bacteria,2I94Z@201174|Actinobacteria	201174|Actinobacteria	G	BNR repeat-containing family member	-	-	-	-	-	-	-	-	-	-	-	-	BNR_4
k59_458195_2	1392498.JQLH01000001_gene150	1.01e-20	89.0	2BZ6M@1|root,2Z7HW@2|Bacteria,4NDZE@976|Bacteroidetes,1HYEC@117743|Flavobacteriia,2PG5Q@252356|Maribacter	976|Bacteroidetes	S	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
k59_235623_1	379066.GAU_1170	5.17e-84	256.0	COG0568@1|root,COG0568@2|Bacteria,1ZSR6@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_1180528_1	558884.JRGM01000009_gene3307	1.59e-68	215.0	COG2102@1|root,COG2102@2|Bacteria,1MUU2@1224|Proteobacteria,1S3D2@1236|Gammaproteobacteria,1Y5C1@135624|Aeromonadales	135624|Aeromonadales	S	Diphthamide synthase	-	-	-	-	-	-	-	-	-	-	-	-	Diphthami_syn_2
k59_791672_1	639030.JHVA01000001_gene2429	1.22e-13	76.6	COG0577@1|root,COG0577@2|Bacteria,3Y6GH@57723|Acidobacteria,2JKMB@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_1458865_1	1397527.Q670_14790	1.09e-06	57.8	COG4942@1|root,COG4942@2|Bacteria,1MY3E@1224|Proteobacteria,1RPQP@1236|Gammaproteobacteria,1XJ9V@135619|Oceanospirillales	135619|Oceanospirillales	D	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_235637_1	357808.RoseRS_1747	3.22e-44	154.0	COG3253@1|root,COG3253@2|Bacteria,2G6WY@200795|Chloroflexi,376C9@32061|Chloroflexia	32061|Chloroflexia	S	PFAM Chlorite dismutase	-	-	-	-	-	-	-	-	-	-	-	-	Chlor_dismutase
k59_1569715_1	639030.JHVA01000001_gene3648	1.06e-15	82.4	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_458221_1	331869.BAL199_25224	6.87e-108	339.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2TQK9@28211|Alphaproteobacteria,4BP8W@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_68529_1	981383.AEWH01000006_gene3011	1.25e-68	223.0	COG2270@1|root,COG2270@2|Bacteria,1TRTH@1239|Firmicutes,4H9VB@91061|Bacilli	91061|Bacilli	S	COG2270 Permeases of the major facilitator superfamily	yxiO	-	-	ko:K06902	ko04138,map04138	-	-	-	ko00000,ko00001,ko02000,ko04131	2.A.1.24,9.A.15.1	-	-	ATG22
k59_346225_2	1172188.KB911820_gene2633	1.27e-41	154.0	COG2132@1|root,COG2132@2|Bacteria,2GMJ4@201174|Actinobacteria,4FG4H@85021|Intrasporangiaceae	201174|Actinobacteria	Q	Multicopper oxidase	-	-	1.3.3.5	ko:K08100	ko00860,ko01110,map00860,map01110	-	R02394	RC01983	ko00000,ko00001,ko01000	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
k59_736179_2	1719.CPTC_00096	2.04e-09	57.0	COG1451@1|root,COG1451@2|Bacteria,2GMP6@201174|Actinobacteria,22N63@1653|Corynebacteriaceae	201174|Actinobacteria	S	Metal-dependent hydrolase	-	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF45
k59_13226_2	1238182.C882_2152	2.02e-18	79.3	COG2350@1|root,COG2350@2|Bacteria,1MZ9Z@1224|Proteobacteria,2UF4X@28211|Alphaproteobacteria,2JTUA@204441|Rhodospirillales	204441|Rhodospirillales	S	Protein conserved in bacteria	-	-	-	ko:K09780	-	-	-	-	ko00000	-	-	-	YCII
k59_402260_1	429009.Adeg_0051	1.17e-71	233.0	COG0504@1|root,COG0504@2|Bacteria,1TP34@1239|Firmicutes,2482E@186801|Clostridia,42F21@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS01075	CTP_synth_N,GATase
k59_1291576_2	426117.M446_0777	2.99e-21	92.0	COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,2TQKG@28211|Alphaproteobacteria,1JXTM@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	Isocitrate/isopropylmalate dehydrogenase	-	-	1.1.1.41	ko:K00030	ko00020,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010	R00709	RC00114	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
k59_179591_2	1397528.Q671_03525	8.95e-35	131.0	COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,1RMCV@1236|Gammaproteobacteria,1XIWE@135619|Oceanospirillales	135619|Oceanospirillales	E	PFAM Cys Met metabolism	-	-	2.5.1.48,4.4.1.1	ko:K01739,ko:K01758	ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017,M00338	R00782,R00999,R01001,R01288,R02408,R02508,R03217,R03260,R04770,R04930,R04944,R04945,R04946,R09366	RC00020,RC00056,RC00069,RC00348,RC00382,RC00420,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Cys_Met_Meta_PP
k59_458261_2	1267535.KB906767_gene3834	1.38e-31	126.0	COG0577@1|root,COG0577@2|Bacteria,3Y31H@57723|Acidobacteria	57723|Acidobacteria	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_1125601_1	1499967.BAYZ01000016_gene6567	8.52e-76	238.0	COG1181@1|root,COG1181@2|Bacteria,2NPB2@2323|unclassified Bacteria	2|Bacteria	M	Belongs to the D-alanine--D-alanine ligase family	ddl	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008716,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016020,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0040007,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	iAF1260.b0381,iB21_1397.B21_00332,iBWG_1329.BWG_0265,iE2348C_1286.E2348C_0317,iEC042_1314.EC042_0413,iEC55989_1330.EC55989_0386,iECBD_1354.ECBD_3283,iECB_1328.ECB_00328,iECDH10B_1368.ECDH10B_0338,iECDH1ME8569_1439.ECDH1ME8569_0367,iECD_1391.ECD_00328,iECH74115_1262.ECH74115_0453,iECIAI1_1343.ECIAI1_0377,iECIAI39_1322.ECIAI39_0301,iECO103_1326.ECO103_0356,iECO111_1330.ECO111_0411,iECO26_1355.ECO26_0414,iECSE_1348.ECSE_0401,iECSP_1301.ECSP_0441,iECs_1301.ECs0431,iETEC_1333.ETEC_0434,iEcDH1_1363.EcDH1_3227,iEcE24377_1341.EcE24377A_0406,iEcHS_1320.EcHS_A0447,iEcSMS35_1347.EcSMS35_0410,iEcolC_1368.EcolC_3251,iJO1366.b0381,iJR904.b0381,iSF_1195.SF0232,iSFxv_1172.SFxv_0245,iS_1188.S0254,iUMNK88_1353.UMNK88_429,iY75_1357.Y75_RS01965,iZ_1308.Z0477	Dala_Dala_lig_C,Dala_Dala_lig_N
k59_13253_1	479433.Caci_8860	0.000102	51.2	COG0265@1|root,COG1286@1|root,COG0265@2|Bacteria,COG1286@2|Bacteria,2GJ92@201174|Actinobacteria	201174|Actinobacteria	O	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain	cvpA	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0009268,GO:0009405,GO:0009628,GO:0010447,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051704,GO:0071944	-	-	-	-	-	-	-	-	-	-	Colicin_V,Trypsin_2
k59_680721_1	1122604.JONR01000010_gene3890	0.000136	49.7	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1X3A2@135614|Xanthomonadales	135614|Xanthomonadales	P	COG0474 Cation transport ATPase	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k59_736210_1	635013.TherJR_2709	1.49e-13	69.7	COG0149@1|root,COG0149@2|Bacteria,1TP2F@1239|Firmicutes,248JN@186801|Clostridia,260CH@186807|Peptococcaceae	186801|Clostridia	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
k59_568694_1	240292.Ava_1029	1.84e-39	150.0	COG0642@1|root,COG0784@1|root,COG2198@1|root,COG2202@1|root,COG3452@1|root,COG3829@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,COG3452@2|Bacteria,COG3829@2|Bacteria,1G09B@1117|Cyanobacteria,1HRJ1@1161|Nostocales	1117|Cyanobacteria	T	Histidine Phosphotransfer domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,GAF,HATPase_c,HisKA,Hpt,PAS_3,PAS_9,Response_reg
k59_346261_1	1122132.AQYH01000004_gene1482	0.000678	46.2	COG1172@1|root,COG1172@2|Bacteria,1MWN4@1224|Proteobacteria,2TV3R@28211|Alphaproteobacteria,4B78S@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10560	ko02010,map02010	M00220	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.9	-	-	BPD_transp_2
k59_346261_2	981369.JQMJ01000004_gene340	7.25e-18	83.6	COG1129@1|root,COG1129@2|Bacteria,2GJ3F@201174|Actinobacteria,2NGR7@228398|Streptacidiphilus	201174|Actinobacteria	G	ATPases associated with a variety of cellular activities	rbsA	-	3.6.3.17	ko:K10562	ko02010,map02010	M00220	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.9	-	-	ABC_tran
k59_736216_1	248742.XP_005647238.1	7.6e-15	75.9	COG0605@1|root,KOG0876@2759|Eukaryota,37PY0@33090|Viridiplantae	33090|Viridiplantae	P	radicals which are normally produced within the cells and which are toxic to biological systems	-	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
k59_568700_2	1429916.X566_19680	4.93e-14	70.1	COG0396@1|root,COG0396@2|Bacteria,1MUGK@1224|Proteobacteria,2TS8T@28211|Alphaproteobacteria,3JTK7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	ATPases associated with a variety of cellular activities	sufC	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
k59_458289_1	1240349.ANGC01000001_gene2510	1e-86	268.0	COG1488@1|root,COG1488@2|Bacteria,2GJAT@201174|Actinobacteria,4G6J9@85025|Nocardiaceae	201174|Actinobacteria	F	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	-	GO:0001666,GO:0003674,GO:0003824,GO:0004516,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009605,GO:0009607,GO:0009628,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016763,GO:0016874,GO:0016879,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0034355,GO:0034641,GO:0034654,GO:0036293,GO:0043094,GO:0043173,GO:0043207,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044403,GO:0044419,GO:0044464,GO:0046483,GO:0046496,GO:0047280,GO:0050896,GO:0051186,GO:0051188,GO:0051701,GO:0051704,GO:0051707,GO:0055086,GO:0070482,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0075136,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	NAPRTase,QRPTase_C
k59_1680859_1	1279038.KB907337_gene700	6.63e-86	268.0	COG0044@1|root,COG0044@2|Bacteria,1MW10@1224|Proteobacteria,2TSQH@28211|Alphaproteobacteria,2JP9W@204441|Rhodospirillales	204441|Rhodospirillales	F	COG0044 Dihydroorotase and related cyclic amidohydrolases	allB	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Urease_alpha
k59_736229_1	1150864.MILUP08_30086	8.6e-45	158.0	COG3178@1|root,COG3178@2|Bacteria,2GNRB@201174|Actinobacteria,4DD76@85008|Micromonosporales	201174|Actinobacteria	S	'Phosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	APH
k59_458332_1	945713.IALB_1631	1.84e-117	353.0	COG1008@1|root,COG1008@2|Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoM2	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
k59_179662_1	443143.GM18_1206	8.46e-64	213.0	COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,42MZZ@68525|delta/epsilon subdivisions,2WIQI@28221|Deltaproteobacteria,43THW@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	MoeA domain protein domain I and II	moeA-1	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
k59_346327_1	379066.GAU_2666	1.14e-37	143.0	COG0823@1|root,COG1228@1|root,COG0823@2|Bacteria,COG1228@2|Bacteria,1ZUMT@142182|Gemmatimonadetes	142182|Gemmatimonadetes	QU	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,PD40
k59_1680911_1	543632.JOJL01000023_gene1812	2.43e-54	188.0	COG2132@1|root,COG2132@2|Bacteria,2IDXQ@201174|Actinobacteria	201174|Actinobacteria	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase_3
k59_123889_1	1122132.AQYH01000019_gene267	3.25e-46	158.0	COG0796@1|root,COG0796@2|Bacteria,1NAI2@1224|Proteobacteria,2TSR7@28211|Alphaproteobacteria,4B8M4@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	-	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	-	Asp_Glu_race
k59_624367_1	107635.AZUO01000005_gene4309	2.53e-145	424.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2TRXG@28211|Alphaproteobacteria,370BU@31993|Methylocystaceae	28211|Alphaproteobacteria	L	Transposase DDE domain	-	-	-	ko:K07487	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_1569850_1	882083.SacmaDRAFT_4868	1.2e-21	97.1	COG2423@1|root,COG2423@2|Bacteria,2H4D8@201174|Actinobacteria	201174|Actinobacteria	E	ornithine cyclodeaminase	ocd	-	1.5.1.51,4.3.1.12	ko:K01750,ko:K21721	ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230	-	R00671	RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
k59_68670_1	1173024.KI912152_gene398	1.35e-58	184.0	COG3393@1|root,COG3393@2|Bacteria,1GF6E@1117|Cyanobacteria	1117|Cyanobacteria	S	-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_7
k59_181769_1	316056.RPC_4476	3.18e-52	172.0	COG1028@1|root,COG1028@2|Bacteria,1MVT2@1224|Proteobacteria,2TQKU@28211|Alphaproteobacteria,3JT2S@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	fixR	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_181774_1	997346.HMPREF9374_3292	5.78e-61	196.0	COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,4HB73@91061|Bacilli,27BNS@186824|Thermoactinomycetaceae	91061|Bacilli	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
k59_1127949_1	1386089.N865_18460	5.16e-80	257.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,2GKXV@201174|Actinobacteria,4FEQG@85021|Intrasporangiaceae	201174|Actinobacteria	C	ferredoxin oxidoreductase	korA	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0030312,GO:0044464,GO:0050896,GO:0055114,GO:0071944	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
k59_460797_1	616991.JPOO01000003_gene652	1.12e-110	331.0	COG0370@1|root,COG0370@2|Bacteria,4NGRN@976|Bacteroidetes,1I03Y@117743|Flavobacteriia	976|Bacteroidetes	P	transporter of a GTP-driven Fe(2 ) uptake system	-	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
k59_70825_2	3067.XP_002954841.1	3.9e-29	114.0	COG0586@1|root,2RZX4@2759|Eukaryota,37VXG@33090|Viridiplantae,34HSP@3041|Chlorophyta	3041|Chlorophyta	S	SNARE associated Golgi protein	-	-	-	ko:K03975	-	-	-	-	ko00000	-	-	-	SNARE_assoc
k59_348465_1	861299.J421_0978	4.92e-82	245.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	3.2.2.1	ko:K01239	ko00230,ko00760,ko01100,map00230,map00760,map01100	-	R01245,R01273,R01677,R01770,R02143	RC00033,RC00063,RC00122,RC00318,RC00485	ko00000,ko00001,ko01000	-	-	-	Glyoxalase,Glyoxalase_4
k59_348465_2	1079986.JH164846_gene1937	6.26e-32	121.0	2C1EG@1|root,2Z7MZ@2|Bacteria,2GK4W@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1016467_1	702438.HMPREF9431_00314	1.35e-23	106.0	COG1287@1|root,COG1287@2|Bacteria,4NEB3@976|Bacteroidetes,2FMA3@200643|Bacteroidia	976|Bacteroidetes	S	Psort location CytoplasmicMembrane, score 10.00	-	-	-	-	-	-	-	-	-	-	-	-	DUF2723
k59_1738681_1	204669.Acid345_2858	3.35e-57	201.0	COG0204@1|root,COG1022@1|root,COG0204@2|Bacteria,COG1022@2|Bacteria,3Y3GW@57723|Acidobacteria,2JHKK@204432|Acidobacteriia	2|Bacteria	I	Phosphate acyltransferases	fadD	-	2.3.1.51,6.2.1.3	ko:K00655,ko:K01897	ko00061,ko00071,ko00561,ko00564,ko01100,ko01110,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map00561,map00564,map01100,map01110,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086,M00089	R01280,R02241,R09381	RC00004,RC00014,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C,Acyltransferase,PP-binding
k59_1461169_1	391625.PPSIR1_20374	3.68e-17	86.3	COG0475@1|root,COG0475@2|Bacteria,1R9PF@1224|Proteobacteria,42RF1@68525|delta/epsilon subdivisions,2WMJJ@28221|Deltaproteobacteria,2Z31T@29|Myxococcales	28221|Deltaproteobacteria	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,PTS_EIIA_2,TrkA_C,TrkA_N
k59_1572011_1	44056.XP_009041391.1	8.36e-07	55.8	28IFH@1|root,2QQSB@2759|Eukaryota	2759|Eukaryota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
k59_1516390_2	1380394.JADL01000002_gene1160	1.76e-115	336.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2U1BU@28211|Alphaproteobacteria,2JW92@204441|Rhodospirillales	204441|Rhodospirillales	E	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
k59_960493_1	204669.Acid345_0985	7.67e-67	212.0	COG0266@1|root,COG0266@2|Bacteria,3Y71J@57723|Acidobacteria,2JKGK@204432|Acidobacteriia	204432|Acidobacteriia	L	Formamidopyrimidine-DNA glycosylase H2TH domain	-	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
k59_1293806_1	1268635.Loa_00268	3.17e-25	101.0	COG3865@1|root,COG3865@2|Bacteria,1N7IY@1224|Proteobacteria,1S25M@1236|Gammaproteobacteria,1JF3J@118969|Legionellales	118969|Legionellales	S	3-demethylubiquinone-9 3-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	3-dmu-9_3-mt
k59_626448_1	886293.Sinac_5229	2.96e-21	87.4	COG3795@1|root,COG3795@2|Bacteria,2IZVT@203682|Planctomycetes	203682|Planctomycetes	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
k59_626448_2	1121939.L861_01560	5.83e-51	165.0	COG0454@1|root,COG0456@2|Bacteria,1RB0Q@1224|Proteobacteria	1224|Proteobacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
k59_905544_1	1379270.AUXF01000006_gene174	1.35e-38	144.0	COG0173@1|root,COG0173@2|Bacteria,1ZTFX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
k59_1293811_1	1206739.BAGJ01000267_gene2953	8.46e-11	67.4	COG1228@1|root,COG1228@2|Bacteria,2GMUS@201174|Actinobacteria,4G153@85025|Nocardiaceae	201174|Actinobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,Amidohydro_3
k59_1738720_2	1207063.P24_17772	1.64e-15	76.3	COG2847@1|root,COG2847@2|Bacteria,1MZ3M@1224|Proteobacteria,2UBUR@28211|Alphaproteobacteria,2JTEB@204441|Rhodospirillales	204441|Rhodospirillales	S	Pfam:DUF461	-	-	-	ko:K09796	-	-	-	-	ko00000,ko03110	-	-	-	PCuAC
k59_1770594_1	981369.JQMJ01000004_gene3141	2.11e-54	189.0	COG0449@1|root,COG0449@2|Bacteria,2GKH0@201174|Actinobacteria,2NFT8@228398|Streptacidiphilus	201174|Actinobacteria	M	Glutamine amidotransferase domain	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016020,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	iNJ661.Rv3436c	GATase_6,SIS
k59_268544_1	1122132.AQYH01000016_gene2844	2.06e-63	207.0	COG3964@1|root,COG3964@2|Bacteria,1MVC7@1224|Proteobacteria,2TSUD@28211|Alphaproteobacteria,4BBMF@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Dihydroorotase	-	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
k59_1105220_1	1538295.JY96_11895	1.43e-34	135.0	COG0515@1|root,COG0515@2|Bacteria,1MVEU@1224|Proteobacteria,2VIWE@28216|Betaproteobacteria,1KJXJ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
k59_496001_1	1161401.ASJA01000006_gene1982	2.07e-31	122.0	COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,2TQQ1@28211|Alphaproteobacteria,43WG1@69657|Hyphomonadaceae	28211|Alphaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
k59_496001_2	1226994.AMZB01000095_gene656	3.34e-05	45.8	COG1028@1|root,COG1028@2|Bacteria,1MU5Y@1224|Proteobacteria,1RP7D@1236|Gammaproteobacteria,1YEH4@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	IQ	KR domain	bdhA	-	1.1.1.30	ko:K00019	ko00072,ko00650,ko01100,map00072,map00650,map01100	M00088	R01361	RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	adh_short,adh_short_C2
k59_1329356_1	525897.Dbac_1642	5.44e-06	53.5	COG0642@1|root,COG2197@1|root,COG2202@1|root,COG2197@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WIR4@28221|Deltaproteobacteria,2M7T3@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365,HATPase_c,HisKA,PAS_3,PAS_4,Response_reg
k59_1659297_1	1157637.KB892111_gene4201	4.65e-66	212.0	COG2267@1|root,COG2267@2|Bacteria,2GU81@201174|Actinobacteria	201174|Actinobacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_496015_1	930169.B5T_01000	5.99e-52	174.0	COG0134@1|root,COG0134@2|Bacteria,1MW5K@1224|Proteobacteria,1RNYH@1236|Gammaproteobacteria,1XIIP@135619|Oceanospirillales	135619|Oceanospirillales	E	Belongs to the TrpC family	trpC	-	4.1.1.48,5.3.1.24	ko:K01609,ko:K13498	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508,R03509	RC00944,RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
k59_159240_1	1382356.JQMP01000004_gene645	2.82e-71	226.0	COG0444@1|root,COG0444@2|Bacteria,2G61B@200795|Chloroflexi,27XUE@189775|Thermomicrobia	189775|Thermomicrobia	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
k59_826500_1	1266925.JHVX01000011_gene1445	2.47e-44	154.0	COG1215@1|root,COG1215@2|Bacteria,1RA75@1224|Proteobacteria,2WA56@28216|Betaproteobacteria,372XS@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_1605085_1	518766.Rmar_0638	5.24e-88	275.0	COG0591@1|root,COG0591@2|Bacteria,4PKHI@976|Bacteroidetes,1FIMH@1100069|Bacteroidetes Order II. Incertae sedis	2|Bacteria	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
k59_826518_1	1122223.KB890696_gene138	3.73e-10	58.9	COG0684@1|root,COG0684@2|Bacteria,1WJWN@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	Pfam:Methyltransf_6	-	-	4.1.3.17	ko:K10218	ko00362,ko00660,ko01120,map00362,map00660,map01120	-	R00008,R00350	RC00067,RC00502,RC01205	ko00000,ko00001,ko01000	-	-	-	RraA-like
k59_826518_2	309801.trd_0904	1.09e-56	183.0	COG2120@1|root,COG2120@2|Bacteria,2G8FR@200795|Chloroflexi,27Y9R@189775|Thermomicrobia	189775|Thermomicrobia	S	GlcNAc-PI de-N-acetylase	-	-	4.2.1.83	ko:K16515	ko00362,map00362	-	R04478	RC00498	ko00000,ko00001,ko01000	-	-	-	PIG-L
k59_159257_2	1501230.ET33_12115	5.45e-08	58.9	COG1595@1|root,COG1595@2|Bacteria,1V9ZH@1239|Firmicutes,4HGNB@91061|Bacilli,26USU@186822|Paenibacillaceae	91061|Bacilli	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_1547430_1	479431.Namu_1732	6.72e-22	100.0	COG2936@1|root,COG2936@2|Bacteria,2GK8B@201174|Actinobacteria,4EVA0@85013|Frankiales	201174|Actinobacteria	S	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
k59_47243_1	383372.Rcas_3207	1.55e-19	93.6	COG1672@1|root,COG2319@1|root,COG1672@2|Bacteria,COG2319@2|Bacteria,2G8HW@200795|Chloroflexi,376W0@32061|Chloroflexia	32061|Chloroflexia	S	WD40 repeats	-	-	-	-	-	-	-	-	-	-	-	-	WD40
k59_159292_1	1105031.HMPREF1141_2353	2.47e-61	197.0	COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,247RK@186801|Clostridia,36EDS@31979|Clostridiaceae	186801|Clostridia	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.2.1.149	ko:K07546,ko:K08299	ko00623,ko01100,ko01120,ko01220,map00623,map01100,map01120,map01220	M00418	R05599,R10675	RC01095,RC01435	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
k59_717881_1	1192124.LIG30_2195	1.09e-30	120.0	COG0451@1|root,COG0451@2|Bacteria,1MX2J@1224|Proteobacteria,2VJHC@28216|Betaproteobacteria,1K1YK@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Nad-dependent epimerase dehydratase	wbiG	-	1.1.1.219,5.1.3.2	ko:K00091,ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
k59_994744_1	575540.Isop_3443	3.16e-08	61.6	COG0515@1|root,COG0515@2|Bacteria,2IX48@203682|Planctomycetes	575540.Isop_3443|-	KLT	COG0515 Serine threonine protein	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	-
k59_1438235_1	240015.ACP_3400	6.71e-41	155.0	COG2120@1|root,COG2120@2|Bacteria,3Y3BV@57723|Acidobacteria,2JIKG@204432|Acidobacteriia	204432|Acidobacteriia	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	NPCBM_assoc,PIG-L
k59_1717375_1	1519464.HY22_02930	3.44e-32	128.0	COG4191@1|root,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,cNMP_binding
k59_496091_2	926569.ANT_24770	2.81e-44	158.0	COG5557@1|root,COG5557@2|Bacteria,2G68D@200795|Chloroflexi	200795|Chloroflexi	C	PFAM Polysulphide reductase, NrfD	-	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	NrfD
k59_1770713_1	1121472.AQWN01000003_gene1550	8.02e-34	136.0	COG2132@1|root,COG2132@2|Bacteria,1V17J@1239|Firmicutes,24FAM@186801|Clostridia,264E3@186807|Peptococcaceae	186801|Clostridia	Q	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	SdrD_B
k59_1438256_1	485915.Dret_2002	2.27e-58	200.0	COG3464@1|root,COG3464@2|Bacteria,1R4DH@1224|Proteobacteria,43AQ4@68525|delta/epsilon subdivisions,2X63W@28221|Deltaproteobacteria,2MGXP@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	PFAM transposase IS204 IS1001 IS1096 IS1165 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,zf-ISL3
k59_769971_1	1379270.AUXF01000006_gene290	6.47e-63	212.0	COG0322@1|root,COG0322@2|Bacteria,1ZSXE@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_5,UVR,UvrC_HhH_N
k59_1105344_1	192952.MM_0503	1.58e-63	206.0	COG1266@1|root,arCOG02768@2157|Archaea,2XYFG@28890|Euryarchaeota	28890|Euryarchaeota	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
k59_1105345_1	46234.ANA_C13142	2.34e-65	214.0	COG3385@1|root,COG3385@2|Bacteria,1G2T1@1117|Cyanobacteria,1HMX0@1161|Nostocales	1117|Cyanobacteria	L	PFAM Transposase DDE domain	-	-	-	ko:K07495	-	-	-	-	ko00000	-	-	-	DDE_5,DDE_Tnp_1
k59_437147_1	926569.ANT_25290	3e-32	131.0	COG0653@1|root,COG0653@2|Bacteria,2G603@200795|Chloroflexi	200795|Chloroflexi	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_437147_2	926569.ANT_05570	2.18e-06	48.9	COG1816@1|root,COG1816@2|Bacteria,2G6AT@200795|Chloroflexi	200795|Chloroflexi	F	PFAM Adenosine AMP deaminase	-	-	3.5.4.4	ko:K01488	ko00230,ko01100,ko05340,map00230,map01100,map05340	-	R01560,R02556	RC00477	ko00000,ko00001,ko01000	-	-	-	A_deaminase
k59_1547492_1	1288494.EBAPG3_20620	3.09e-47	158.0	COG1544@1|root,COG1544@2|Bacteria,1RJ55@1224|Proteobacteria,2VR5Q@28216|Betaproteobacteria,372T2@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Sigma 54 modulation protein / S30EA ribosomal protein	-	-	-	-	-	-	-	-	-	-	-	-	CSD,Ribosomal_S30AE
k59_1274905_1	537007.BLAHAN_04724	3.84e-13	72.8	COG0682@1|root,COG0682@2|Bacteria,1TPAK@1239|Firmicutes,24BK7@186801|Clostridia,3XZV7@572511|Blautia	186801|Clostridia	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
k59_548439_1	1089552.KI911559_gene304	4.39e-68	221.0	COG2114@1|root,COG2114@2|Bacteria,1MV1V@1224|Proteobacteria,2TRUC@28211|Alphaproteobacteria,2JQP6@204441|Rhodospirillales	204441|Rhodospirillales	T	COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain)	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc
k59_328450_1	1499967.BAYZ01000184_gene4567	3.62e-37	143.0	COG0480@1|root,COG0480@2|Bacteria,2NNQD@2323|unclassified Bacteria	2|Bacteria	J	elongation factor G	fusA-1	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_1277516_1	1134474.O59_002469	9.63e-36	135.0	COG2730@1|root,COG2730@2|Bacteria,1R5GC@1224|Proteobacteria,1S10V@1236|Gammaproteobacteria,1FHUH@10|Cellvibrio	1236|Gammaproteobacteria	G	CBD_II	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	CBM_10,CBM_2,Cellulase
k59_550197_1	671143.DAMO_0507	3.23e-33	123.0	COG0462@1|root,COG0462@2|Bacteria,2NNP6@2323|unclassified Bacteria	2|Bacteria	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	GO:0003674,GO:0003824,GO:0004749,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016772,GO:0016778,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2848	Pribosyl_synth,Pribosyltran_N
k59_550197_2	330214.NIDE0782	5.54e-22	93.2	COG1825@1|root,COG1825@2|Bacteria,3J0NK@40117|Nitrospirae	40117|Nitrospirae	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
k59_885342_1	1510531.JQJJ01000010_gene2597	2.61e-65	209.0	COG0142@1|root,COG0142@2|Bacteria,1MWNG@1224|Proteobacteria,2TR79@28211|Alphaproteobacteria,3JTEJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	H	Belongs to the FPP GGPP synthase family	ispA	GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009536,GO:0009842,GO:0009987,GO:0016114,GO:0016740,GO:0016765,GO:0019637,GO:0033385,GO:0033386,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0090407,GO:1901576	2.5.1.1,2.5.1.10	ko:K00795	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364	R01658,R02003	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
k59_1217311_1	1163407.UU7_04737	1.84e-52	174.0	COG1834@1|root,COG1834@2|Bacteria,1MZ9U@1224|Proteobacteria,1RN0M@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Amidinotransferase	-	-	3.5.3.18	ko:K01482	-	-	-	-	ko00000,ko01000,ko04147	-	-	-	Amidinotransf
k59_105820_1	204669.Acid345_0942	2.84e-94	288.0	COG0334@1|root,COG0334@2|Bacteria,3Y3B4@57723|Acidobacteria,2JI4Q@204432|Acidobacteriia	2|Bacteria	E	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.4	ko:K00262	ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100	-	R00248	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
k59_659533_1	378806.STAUR_5560	3.83e-43	156.0	COG2870@1|root,COG2870@2|Bacteria,1MV3Z@1224|Proteobacteria,42MBC@68525|delta/epsilon subdivisions,2WIKU@28221|Deltaproteobacteria,2YYUP@29|Myxococcales	28221|Deltaproteobacteria	M	Phosphomethylpyrimidine kinase	hldE	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016757,GO:0016772,GO:0019200,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0046835,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.7.1.167,2.7.7.70	ko:K03272	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	iAF987.Gmet_0922	CTP_transf_like,PfkB
k59_1053137_1	1278073.MYSTI_02797	2.88e-13	75.1	COG0577@1|root,COG0577@2|Bacteria,1NREW@1224|Proteobacteria	1224|Proteobacteria	V	COG0577 ABC-type antimicrobial peptide transport system permease component	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_214245_1	1298858.AUEL01000005_gene1182	3.88e-08	57.8	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria,43HNC@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	heavy metal translocating P-type ATPase	actP	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase,YHS
k59_214245_2	1211777.BN77_2541	8.77e-13	67.8	COG2020@1|root,COG2020@2|Bacteria,1MUBZ@1224|Proteobacteria,2TQZQ@28211|Alphaproteobacteria,4BCXG@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	Isoprenylcysteine carboxyl methyltransferase (ICMT) family	-	-	-	-	-	-	-	-	-	-	-	-	ICMT,PEMT
k59_996503_1	1500259.JQLD01000010_gene4825	5.11e-45	164.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TVI3@28211|Alphaproteobacteria,4BCQJ@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	-	-	-	-	-	-	-	-	-	TctA
k59_604514_2	867845.KI911784_gene1819	2.8e-31	120.0	COG2041@1|root,COG2041@2|Bacteria,2G618@200795|Chloroflexi,375BB@32061|Chloroflexia	32061|Chloroflexia	C	Part of the MsrPQ system that repairs oxidized cell envelope proteins containing methionine sulfoxide residues (Met- O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated cell envelope proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide	msrP	-	-	ko:K07147	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_molyb
k59_1386650_1	1540221.JQNI01000002_gene595	3.51e-37	145.0	COG0514@1|root,COG1199@1|root,COG0514@2|Bacteria,COG1199@2|Bacteria,1WJC6@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	L	TIGRFAM ATP-dependent DNA helicase, RecQ	-	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,DEAD_2,Helicase_C,Helicase_C_2,RNase_T,RecQ_Zn_bind
k59_1386654_1	1203611.KB894544_gene2039	3.06e-07	52.0	COG1131@1|root,COG1131@2|Bacteria,4NFW9@976|Bacteroidetes,2G20C@200643|Bacteroidia,22UXQ@171550|Rikenellaceae	976|Bacteroidetes	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1386654_2	909663.KI867150_gene2870	2.33e-32	120.0	arCOG11509@1|root,31KIR@2|Bacteria,1RGVE@1224|Proteobacteria,42T74@68525|delta/epsilon subdivisions,2WPQ8@28221|Deltaproteobacteria,2MRR6@213462|Syntrophobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1498166_1	1123367.C666_14835	0.000623	42.4	COG1524@1|root,COG1524@2|Bacteria,1R2II@1224|Proteobacteria,2VMR9@28216|Betaproteobacteria,2KW7I@206389|Rhodocyclales	206389|Rhodocyclales	S	type I phosphodiesterase nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
k59_1498166_2	314278.NB231_16673	5.3e-59	187.0	29DT0@1|root,300QV@2|Bacteria,1RGE1@1224|Proteobacteria,1S7BN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Cytochrome P460	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_P460
k59_720194_1	926569.ANT_22380	4.35e-95	287.0	COG3250@1|root,COG3250@2|Bacteria	2|Bacteria	G	beta-galactosidase activity	-	-	3.2.1.23,3.2.1.97	ko:K01190,ko:K17624	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	GH101	-	DUF2804
k59_828821_1	713586.KB900536_gene384	3.37e-115	336.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,1RR3R@1236|Gammaproteobacteria,1WXTU@135613|Chromatiales	135613|Chromatiales	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1277573_1	383372.Rcas_0286	5.83e-14	70.5	COG1011@1|root,COG1011@2|Bacteria,2G916@200795|Chloroflexi,377HS@32061|Chloroflexia	32061|Chloroflexia	S	PFAM Haloacid dehalogenase domain protein hydrolase	-	-	3.8.1.2	ko:K01560,ko:K07025	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	HAD_2
k59_1277573_2	43151.ADAC002703-PA	7.14e-30	119.0	COG2896@1|root,KOG2876@2759|Eukaryota,38F0A@33154|Opisthokonta,3B9J0@33208|Metazoa,3D129@33213|Bilateria,41TPK@6656|Arthropoda,3SGTS@50557|Insecta,4502P@7147|Diptera,45BEM@7148|Nematocera	33208|Metazoa	H	MoaC family	MOCS1	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016829,GO:0016830,GO:0016849,GO:0018130,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0032324,GO:0034641,GO:0042278,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051189,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0061798,GO:0061799,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657	4.1.99.22,4.6.1.17	ko:K20967	ko00790,ko01100,map00790,map01100	-	R09394,R11372	RC03420,RC03425	ko00000,ko00001,ko01000	-	-	-	Fer4_12,MoaC,Mob_synth_C,Radical_SAM
k59_105857_1	1280679.ATVX01000006_gene1430	0.000555	47.8	COG3757@1|root,COG3757@2|Bacteria,1V3YK@1239|Firmicutes,25KMS@186801|Clostridia,4BYE8@830|Butyrivibrio	186801|Clostridia	M	Glycosyl hydrolases family 25	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_25
k59_439552_1	1211114.ALIP01000080_gene2545	4.77e-42	148.0	COG0491@1|root,COG0491@2|Bacteria,1MXKX@1224|Proteobacteria,1RR31@1236|Gammaproteobacteria,1X47R@135614|Xanthomonadales	135614|Xanthomonadales	S	Zn-dependent hydrolases including glyoxylases	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_498454_1	324602.Caur_0966	3.75e-20	91.3	COG2766@1|root,COG2766@2|Bacteria,2G65T@200795|Chloroflexi,3756U@32061|Chloroflexia	32061|Chloroflexia	T	PFAM PrkA serine kinase	-	-	-	ko:K07180	-	-	-	-	ko00000	-	-	-	AAA_PrkA,PrkA
k59_604547_1	379066.GAU_1737	3.45e-23	101.0	COG0046@1|root,COG0046@2|Bacteria,1ZT8W@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
k59_604547_2	671143.DAMO_1501	1.63e-07	52.8	COG0034@1|root,COG0034@2|Bacteria,2NNSY@2323|unclassified Bacteria	2|Bacteria	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009507,GO:0009536,GO:0040007,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	iSB619.SA_RS05225	GATase_6,GATase_7,Pribosyltran
k59_943282_1	1198452.Jab_1c07880	2.96e-09	63.2	COG0699@1|root,COG0699@2|Bacteria,1MXBK@1224|Proteobacteria,2VKA1@28216|Betaproteobacteria,4732I@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Dynamin family	-	-	-	-	-	-	-	-	-	-	-	-	Dynamin_N
k59_771960_1	1122179.KB890452_gene4628	2.36e-28	112.0	COG0626@1|root,COG0626@2|Bacteria,4NF0Q@976|Bacteroidetes,1INVN@117747|Sphingobacteriia	976|Bacteroidetes	E	PFAM Cys Met metabolism	metC	-	2.5.1.48,4.4.1.1,4.4.1.8	ko:K01739,ko:K01758,ko:K01760	ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017,M00338	R00782,R00999,R01001,R01286,R01288,R02408,R02508,R03217,R03260,R04770,R04930,R04941,R04944,R04945,R04946,R09366	RC00020,RC00056,RC00069,RC00348,RC00382,RC00420,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Cys_Met_Meta_PP
k59_161623_1	98439.AJLL01000033_gene3374	2.04e-72	236.0	COG3540@1|root,COG3540@2|Bacteria,1G0C9@1117|Cyanobacteria,1JKIQ@1189|Stigonemataceae	1117|Cyanobacteria	P	PhoD-like phosphatase, N-terminal domain	phoD	-	3.1.3.1	ko:K01113	ko00790,ko01100,ko02020,map00790,map01100,map02020	M00126	R04620	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PhoD,PhoD_N
k59_1332341_1	861299.J421_2794	1.2e-86	271.0	COG0201@1|root,COG0201@2|Bacteria,1ZSYZ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
k59_1332341_2	891968.Anamo_0493	2.18e-37	132.0	COG0200@1|root,COG0200@2|Bacteria,3TB6A@508458|Synergistetes	508458|Synergistetes	J	binds to the 23S rRNA	rplO	-	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
k59_1164890_1	1499967.BAYZ01000095_gene4126	7.47e-121	362.0	COG2192@1|root,COG2192@2|Bacteria,2NNRR@2323|unclassified Bacteria	2|Bacteria	O	Carbamoyltransferase C-terminus	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
k59_1107711_1	1499967.BAYZ01000095_gene4203	5.91e-30	122.0	COG0642@1|root,COG3292@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,COG3292@2|Bacteria,2NQMI@2323|unclassified Bacteria	2|Bacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HATPase_c,HisKA,Hpt,PAS_3,Reg_prop,Response_reg,Y_Y_Y
k59_1277648_1	485913.Krac_5082	3.71e-24	102.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	-	GO:0003674,GO:0003824,GO:0016787,GO:0016788,GO:0052689	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Abhydrolase_6,Cu_amine_oxidN1,DLH,DUF3887,Hydrolase_4,Peptidase_S9
k59_828882_1	471853.Bcav_3645	1.47e-25	103.0	COG1704@1|root,COG1704@2|Bacteria,2GPS4@201174|Actinobacteria	201174|Actinobacteria	J	LemA family	lemA	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
k59_1386745_2	1380394.JADL01000007_gene4680	8.99e-30	110.0	COG0346@1|root,COG0346@2|Bacteria,1RIUN@1224|Proteobacteria,2U9CD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
k59_1607483_1	357808.RoseRS_0017	3.4e-90	272.0	COG1309@1|root,COG1309@2|Bacteria,2GAFT@200795|Chloroflexi,375ZP@32061|Chloroflexia	32061|Chloroflexia	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_550298_1	926569.ANT_23510	2.95e-39	145.0	COG1470@1|root,COG1470@2|Bacteria,2G6XR@200795|Chloroflexi	200795|Chloroflexi	S	Protein of unknown function (DUF3048) C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3048,DUF3048_C
k59_1440607_1	1242864.D187_008934	1.19e-123	394.0	COG2132@1|root,COG2132@2|Bacteria,1N9H3@1224|Proteobacteria,42Z37@68525|delta/epsilon subdivisions,2WUNE@28221|Deltaproteobacteria,2YZFR@29|Myxococcales	28221|Deltaproteobacteria	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1719140_1	472759.Nhal_3413	1.76e-81	248.0	COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,1S032@1236|Gammaproteobacteria,1X250@135613|Chromatiales	135613|Chromatiales	S	Possible lysine decarboxylase	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
k59_105923_2	1123023.JIAI01000016_gene3393	2.61e-07	55.1	COG1294@1|root,COG1294@2|Bacteria,2GN42@201174|Actinobacteria,4E96Z@85010|Pseudonocardiales	201174|Actinobacteria	C	Cytochrome bd terminal oxidase subunit II	-	-	1.10.3.14	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_II
k59_1678022_1	1408322.JHYK01000003_gene1186	3.75e-17	87.0	COG0768@1|root,COG0768@2|Bacteria,1TQHY@1239|Firmicutes,2480Z@186801|Clostridia,27IKA@186928|unclassified Lachnospiraceae	186801|Clostridia	M	Penicillin-binding Protein dimerisation domain	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
k59_1344383_1	419610.Mext_1277	8.09e-09	55.8	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TQK7@28211|Alphaproteobacteria,1JS2U@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	PFAM extracellular solute-binding protein family 5	MA20_19390	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_1344383_2	1116369.KB890025_gene5010	1.69e-35	131.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TTTE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EP	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_455273_1	663610.JQKO01000007_gene2307	8e-77	239.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,2TRSS@28211|Alphaproteobacteria,3NACS@45404|Beijerinckiaceae	28211|Alphaproteobacteria	C	Dehydrogenase E1 component	acoA	-	1.2.4.1,1.2.4.4	ko:K00161,ko:K00166,ko:K21416	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,OxoDH_E1alpha_N
k59_843842_1	1121104.AQXH01000001_gene1120	1.97e-28	117.0	COG4399@1|root,COG4399@2|Bacteria	2|Bacteria	-	-	yheB	-	-	-	-	-	-	-	-	-	-	-	DUF445
k59_1234548_1	192222.Cj0783	3.54e-21	92.4	COG3043@1|root,COG3043@2|Bacteria,1NAZB@1224|Proteobacteria,42SN1@68525|delta/epsilon subdivisions,2YPF9@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	C	Electron transfer subunit of the periplasmic nitrate reductase complex NapAB	napB	-	-	ko:K02568	ko00910,ko01120,map00910,map01120	M00529,M00530	R00798	RC02812	ko00000,ko00001,ko00002	-	-	-	NapB
k59_10470_2	512565.AMIS_22690	5.31e-13	72.0	COG0477@1|root,COG2814@2|Bacteria,2I2EY@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
k59_455292_1	80637.XP_007772635.1	6.55e-14	75.9	COG1063@1|root,KOG0024@2759|Eukaryota,38I3Q@33154|Opisthokonta,3NZVH@4751|Fungi,3UZ4S@5204|Basidiomycota,226VF@155619|Agaricomycetes	4751|Fungi	Q	NADP -dependent D-mannitol dehydrogenase	-	-	1.1.1.287	ko:K17818	ko00040,ko01100,map00040,map01100	-	R07143,R07144	RC00102	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_1011305_2	1379270.AUXF01000006_gene133	1.51e-32	121.0	COG1077@1|root,COG1077@2|Bacteria,1ZT9B@142182|Gemmatimonadetes	142182|Gemmatimonadetes	D	Hsp70 protein	-	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
k59_232907_1	383381.EH30_13660	1.5e-16	85.1	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,2TVGG@28211|Alphaproteobacteria,2K0BX@204457|Sphingomonadales	204457|Sphingomonadales	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
k59_232909_1	1336208.JADY01000001_gene809	6.81e-57	192.0	COG2755@1|root,COG2755@2|Bacteria,1MXBN@1224|Proteobacteria,2U079@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	COG2755 Lysophospholipase L1 and related esterases	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
k59_343590_1	247490.KSU1_D0700	1.81e-38	145.0	COG0772@1|root,COG0772@2|Bacteria,2IZT9@203682|Planctomycetes	203682|Planctomycetes	D	Belongs to the SEDS family	-	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
k59_343590_2	935837.JAEK01000014_gene5092	2.54e-11	65.9	COG0707@1|root,COG0707@2|Bacteria,1TQFT@1239|Firmicutes,4HBAQ@91061|Bacilli,1ZBA5@1386|Bacillus	91061|Bacilli	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
k59_1622142_1	251229.Chro_3919	3.89e-22	99.4	2DBUW@1|root,2ZB85@2|Bacteria,1G01C@1117|Cyanobacteria,3VN1Y@52604|Pleurocapsales	1117|Cyanobacteria	S	IMG reference gene	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_677790_1	745718.JADT01000012_gene1012	4.72e-27	110.0	COG3547@1|root,COG3547@2|Bacteria,4NF2F@976|Bacteroidetes,1HXCM@117743|Flavobacteriia	976|Bacteroidetes	L	COG3547 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_343631_1	1411123.JQNH01000001_gene2516	0.000304	48.5	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,2TSR0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Phytoene dehydrogenase	MA20_01895	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
k59_621635_1	710111.FraQA3DRAFT_3001	2.24e-63	205.0	COG0451@1|root,COG0451@2|Bacteria,2I2EG@201174|Actinobacteria,4EUA3@85013|Frankiales	201174|Actinobacteria	GM	epimerase dehydratase	-	-	4.2.1.46,5.1.3.2	ko:K01710,ko:K01784	ko00052,ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00052,map00520,map00521,map00523,map00525,map01055,map01100,map01130	M00361,M00362,M00632,M00793	R00291,R02984,R06513	RC00289,RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
k59_1456210_1	1122179.KB890436_gene1362	5.05e-51	180.0	COG1757@1|root,COG1757@2|Bacteria,4NFF8@976|Bacteroidetes,1IXHV@117747|Sphingobacteriia	976|Bacteroidetes	C	Na+/H+ antiporter family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_antiporter
k59_1733676_1	1047013.AQSP01000108_gene2058	2.81e-55	196.0	COG2091@1|root,COG2091@2|Bacteria,2NQGR@2323|unclassified Bacteria	2|Bacteria	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
k59_455390_1	1454004.AW11_03574	9.63e-109	345.0	COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,2VH05@28216|Betaproteobacteria,1KQDH@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	EI	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly	icmF	GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0006139,GO:0006163,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016866,GO:0017076,GO:0017111,GO:0019001,GO:0019637,GO:0019693,GO:0019842,GO:0031419,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0034784,GO:0035383,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043603,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046872,GO:0046906,GO:0047727,GO:0048037,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564	5.4.99.13	ko:K11942	-	-	-	-	ko00000,ko01000	-	-	-	ArgK,B12-binding,MM_CoA_mutase
k59_1344488_1	991905.SL003B_3211	7.8e-98	290.0	COG2993@1|root,COG2993@2|Bacteria,1MXEY@1224|Proteobacteria,2TRGW@28211|Alphaproteobacteria,4BRCM@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Cytochrome C oxidase, mono-heme subunit/FixO	ccoO	-	-	ko:K00405	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	FixO
k59_177049_1	1122132.AQYH01000005_gene643	4.33e-68	220.0	COG0642@1|root,COG0642@2|Bacteria,1QU3Y@1224|Proteobacteria,2TVYH@28211|Alphaproteobacteria,4B7BU@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Histidine kinase	regB	-	2.7.13.3	ko:K15011	ko02020,map02020	M00523	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
k59_121316_1	1382359.JIAL01000001_gene2198	7.28e-39	140.0	COG1028@1|root,COG1028@2|Bacteria,3Y4CZ@57723|Acidobacteria,2JMNQ@204432|Acidobacteriia	204432|Acidobacteriia	IQ	KR domain	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_65891_1	264198.Reut_C6357	4.12e-16	79.3	COG2721@1|root,COG2721@2|Bacteria,1MU9V@1224|Proteobacteria	1224|Proteobacteria	G	Dehydratase	-	-	4.2.1.7,4.4.1.24	ko:K16846,ko:K16850	ko00040,ko00270,ko01100,map00040,map00270,map01100	M00631	R01540,R07633	RC00543,RC01785	ko00000,ko00001,ko00002,ko01000	-	-	-	GD_AH_C
k59_65891_2	715226.ABI_08160	5.84e-11	63.9	COG2721@1|root,COG2721@2|Bacteria,1MU9V@1224|Proteobacteria,2TTDT@28211|Alphaproteobacteria,2KFBT@204458|Caulobacterales	204458|Caulobacterales	G	PFAM D-galactarate dehydratase Altronate hydrolase	-	-	4.2.1.7	ko:K01685	ko00040,ko01100,map00040,map01100	M00631	R01540	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	GD_AH_C,SAF
k59_10579_1	861299.J421_3554	2.79e-34	129.0	COG0811@1|root,COG0811@2|Bacteria,1ZTBF@142182|Gemmatimonadetes	142182|Gemmatimonadetes	U	MotA/TolQ/ExbB proton channel family	-	-	-	ko:K03562	ko01120,map01120	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	MotA_ExbB
k59_10579_2	1120985.AUMI01000014_gene1199	1.68e-25	105.0	COG1087@1|root,COG1087@2|Bacteria,1TQ7N@1239|Firmicutes,4H26C@909932|Negativicutes	909932|Negativicutes	M	NAD dependent epimerase dehydratase family protein	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
k59_121317_1	1452536.JARE01000066_gene1203	1.71e-53	180.0	COG3119@1|root,COG3119@2|Bacteria,2GJ8H@201174|Actinobacteria	201174|Actinobacteria	P	Pfam Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase,Sulfatase_C
k59_343678_2	767434.Fraau_3079	3.81e-11	65.9	COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,1RPMB@1236|Gammaproteobacteria,1X3I7@135614|Xanthomonadales	135614|Xanthomonadales	S	peptidoglycan-binding protein, lysm	-	-	-	-	-	-	-	-	-	-	-	-	LysM
k59_1511523_1	1122929.KB908215_gene451	4.02e-76	238.0	COG0416@1|root,COG0416@2|Bacteria,1MVM3@1224|Proteobacteria,2TR53@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
k59_955439_1	1206725.BAFU01000218_gene4281	2.52e-52	181.0	COG1012@1|root,COG1012@2|Bacteria,2GJ95@201174|Actinobacteria,4FWXS@85025|Nocardiaceae	201174|Actinobacteria	C	Aldehyde dehydrogenase family	-	-	1.2.99.10	ko:K22445	-	-	-	-	ko00000,ko01000	-	-	-	Aldedh
k59_1234695_1	1167006.UWK_00703	1.83e-63	216.0	COG0038@1|root,COG0517@1|root,COG0569@1|root,COG0038@2|Bacteria,COG0517@2|Bacteria,COG0569@2|Bacteria,1MV4K@1224|Proteobacteria,42N93@68525|delta/epsilon subdivisions,2WJ9N@28221|Deltaproteobacteria,2MHX8@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Voltage gated chloride channel	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,TrkA_C,Voltage_CLC
k59_621690_1	1122128.AUEE01000003_gene803	4.71e-28	107.0	COG1335@1|root,COG1335@2|Bacteria,1V7MY@1239|Firmicutes,4HDR2@91061|Bacilli	91061|Bacilli	Q	isochorismatase	yddQ	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
k59_1289030_2	1123248.KB893315_gene3007	7.67e-22	95.1	COG2211@1|root,COG2211@2|Bacteria,4NE3F@976|Bacteroidetes,1IPIA@117747|Sphingobacteriia	976|Bacteroidetes	G	Major Facilitator	-	-	-	ko:K16211	-	-	-	-	ko00000,ko02000	2.A.2.6	-	-	MFS_1
k59_510673_1	264732.Moth_1981	7.22e-07	55.8	COG0715@1|root,COG0715@2|Bacteria,1TT2F@1239|Firmicutes,249M2@186801|Clostridia,42H3Q@68295|Thermoanaerobacterales	186801|Clostridia	P	TIGRFAM aliphatic sulfonates family ABC transporter, periplsmic ligand-binding protein	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1_2,Phosphonate-bd
k59_1567189_1	395492.Rleg2_4563	1.15e-27	116.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,TPR_8
k59_1567190_1	340177.Cag_0075	4.88e-10	61.2	COG0550@1|root,COG0550@2|Bacteria,1FD5Q@1090|Chlorobi	1090|Chlorobi	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
k59_510681_1	458817.Shal_2976	1.02e-22	96.7	COG0575@1|root,COG0575@2|Bacteria,1MWSV@1224|Proteobacteria,1RQ6M@1236|Gammaproteobacteria,2QA6F@267890|Shewanellaceae	1236|Gammaproteobacteria	M	Belongs to the CDS family	cdsA	GO:0003674,GO:0003824,GO:0004605,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016020,GO:0016024,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044281,GO:0044464,GO:0045017,GO:0046341,GO:0046471,GO:0046474,GO:0046483,GO:0046486,GO:0055086,GO:0070567,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iJN746.PP_1596,iSDY_1059.SDY_0191	CTP_transf_1
k59_510681_2	1111728.ATYS01000020_gene3917	3.05e-10	60.8	COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,1RNNW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	iAPECO1_1312.APECO1_1814,iECOK1_1307.ECOK1_0174,iECS88_1305.ECS88_0183,iUMN146_1321.UM146_23670,iUTI89_1310.UTI89_C0188	DXPR_C,DXP_redisom_C,DXP_reductoisom
k59_65934_1	1189612.A33Q_4381	9.85e-61	201.0	COG0438@1|root,COG0438@2|Bacteria,4NFPA@976|Bacteroidetes,47JT9@768503|Cytophagia	976|Bacteroidetes	M	PFAM Glycosyl transferases group 1	bshA	-	-	ko:K00754	-	-	-	-	ko00000,ko01000	-	GT4	-	Glyco_transf_4,Glycos_transf_1
k59_677932_1	671143.DAMO_2716	6.27e-64	204.0	COG0113@1|root,COG0113@2|Bacteria,2NNST@2323|unclassified Bacteria	2|Bacteria	H	Belongs to the ALAD family	hemB	GO:0000287,GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0030312,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iECABU_c1320.ECABU_c04500,iEcSMS35_1347.EcSMS35_0398,iJN746.PP_2913,ic_1306.c0477	ALAD
k59_1624334_1	1379270.AUXF01000006_gene42	3.07e-139	401.0	COG0468@1|root,COG0468@2|Bacteria,1ZT78@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
k59_512922_1	264198.Reut_C6324	1.78e-42	152.0	COG4638@1|root,COG4638@2|Bacteria,1MX47@1224|Proteobacteria,2W0QT@28216|Betaproteobacteria,1KDAD@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Rieske [2Fe-2S] domain	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
k59_957614_1	926554.KI912617_gene4815	3.35e-18	87.0	COG0612@1|root,COG0612@2|Bacteria,1WM19@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Belongs to the peptidase M16 family	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_957614_2	1123504.JQKD01000018_gene1980	1.3e-24	98.2	COG0782@1|root,COG0782@2|Bacteria,1RAP0@1224|Proteobacteria,2VQ09@28216|Betaproteobacteria,4ABEW@80864|Comamonadaceae	28216|Betaproteobacteria	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length	greB	-	-	ko:K04760	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
k59_568249_1	1207055.C100_01370	2.69e-10	59.3	COG0745@1|root,COG0745@2|Bacteria,1RD7E@1224|Proteobacteria,2U745@28211|Alphaproteobacteria,2K53C@204457|Sphingomonadales	204457|Sphingomonadales	T	response regulator	-	-	-	ko:K11443	ko02020,ko04112,map02020,map04112	M00511	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
k59_568249_2	502025.Hoch_2554	4.94e-23	100.0	COG0642@1|root,COG0784@1|root,COG2198@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WJCX@28221|Deltaproteobacteria,2YXI4@29|Myxococcales	68525|delta/epsilon subdivisions	T	PFAM ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,Hpt,PAS_9,Response_reg
k59_791271_1	1121033.AUCF01000001_gene2227	1.38e-35	133.0	COG0265@1|root,COG0265@2|Bacteria,1MURF@1224|Proteobacteria,2TUVW@28211|Alphaproteobacteria,2JRVV@204441|Rhodospirillales	204441|Rhodospirillales	O	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
k59_1180145_1	1187848.AJYQ01000066_gene3617	9.39e-05	47.0	COG0745@1|root,COG0745@2|Bacteria,1RHDD@1224|Proteobacteria,1S67R@1236|Gammaproteobacteria,1XY6H@135623|Vibrionales	135623|Vibrionales	T	cheY-homologous receiver domain	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
k59_457755_1	671143.DAMO_3125	1.6e-36	130.0	COG0494@1|root,COG0494@2|Bacteria,2NPTC@2323|unclassified Bacteria	2|Bacteria	L	NUDIX domain	nudF	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS05505,iSB619.SA_RS07540,iYO844.BSU23610	NUDIX
k59_1346739_1	502025.Hoch_6518	1.96e-51	182.0	COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,42QKW@68525|delta/epsilon subdivisions,2WKH1@28221|Deltaproteobacteria,2YWTQ@29|Myxococcales	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_1237000_1	751994.AGIG01000034_gene504	1.63e-26	107.0	COG1053@1|root,COG1053@2|Bacteria,1MX5A@1224|Proteobacteria,1RN0D@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	required for the utilization of tricarballylate as a carbon and energy source by S. enterica	cobZ	-	-	ko:K13796	-	-	-	-	ko00000	-	-	-	FAD_binding_2
k59_1237000_2	477184.KYC_22871	6.55e-46	163.0	COG1146@1|root,COG1146@2|Bacteria,1MU2I@1224|Proteobacteria,2VJHI@28216|Betaproteobacteria,3T21S@506|Alcaligenaceae	28216|Betaproteobacteria	C	utilization protein B	citB	-	-	ko:K13795	-	-	-	-	ko00000	-	-	-	-
k59_1624367_1	468059.AUHA01000004_gene2395	7.6e-08	53.9	2CESB@1|root,2Z8UZ@2|Bacteria,4NJSJ@976|Bacteroidetes,1IVD7@117747|Sphingobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1624367_2	1151126.AQYI01000007_gene1375	9.4e-13	69.7	COG1090@1|root,COG1090@2|Bacteria,2GU34@201174|Actinobacteria,4FM2H@85023|Microbacteriaceae	201174|Actinobacteria	S	Domain of unknown function (DUF1731)	-	-	-	ko:K07071	-	-	-	-	ko00000	-	-	-	DUF1731,Epimerase
k59_791288_1	331869.BAL199_10862	4.18e-83	276.0	COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,2TS89@28211|Alphaproteobacteria,4BPMR@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Bacterial NAD-glutamate dehydrogenase	gdhB	GO:0003674,GO:0003824,GO:0004352,GO:0004353,GO:0008150,GO:0008152,GO:0016491,GO:0016638,GO:0016639,GO:0055114	1.4.1.2	ko:K15371	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	-	R00243	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	Bac_GDH
k59_1680389_1	323261.Noc_2062	1.27e-47	167.0	COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,1RN76@1236|Gammaproteobacteria,1WW0E@135613|Chromatiales	135613|Chromatiales	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	-	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
k59_1680389_2	1095769.CAHF01000022_gene180	4.83e-15	74.3	COG0053@1|root,COG0053@2|Bacteria,1MVH8@1224|Proteobacteria,2VNZ1@28216|Betaproteobacteria,475PJ@75682|Oxalobacteraceae	28216|Betaproteobacteria	P	Cation efflux family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux
k59_123419_1	1190606.AJYG01000167_gene3957	4.24e-37	137.0	COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,1RS7J@1236|Gammaproteobacteria,1XUP2@135623|Vibrionales	135623|Vibrionales	EP	N-terminal TM domain of oligopeptide transport permease C	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
k59_1013770_1	177437.HRM2_44190	7.52e-26	112.0	COG5598@1|root,COG5598@2|Bacteria,1MWJN@1224|Proteobacteria,42Q8R@68525|delta/epsilon subdivisions,2WMDK@28221|Deltaproteobacteria,2MJEG@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Trimethylamine methyltransferase	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
k59_846126_1	379066.GAU_1150	1.02e-50	187.0	COG5000@1|root,COG5000@2|Bacteria,1ZSZU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
k59_1068913_1	1335757.SPICUR_03330	5.83e-28	116.0	COG2176@1|root,COG5002@1|root,COG2176@2|Bacteria,COG5002@2|Bacteria,1QZKC@1224|Proteobacteria	1224|Proteobacteria	L	EXOIII	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
k59_1624388_1	518766.Rmar_1442	3.74e-68	219.0	COG0577@1|root,COG0577@2|Bacteria,4NECN@976|Bacteroidetes,1FIY8@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_1735910_1	1120934.KB894451_gene2946	1.45e-75	244.0	COG0034@1|root,COG0034@2|Bacteria,2GK6I@201174|Actinobacteria,4DZFC@85010|Pseudonocardiales	201174|Actinobacteria	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	GO:0008150,GO:0040007	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
k59_235266_1	740709.A10D4_02237	3.13e-80	259.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPCU@1236|Gammaproteobacteria,2QF9H@267893|Idiomarinaceae	1236|Gammaproteobacteria	S	mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth	uup	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010528,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0031323,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0070894,GO:0071944,GO:0080090,GO:0097159,GO:1901363	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
k59_1735918_1	247490.KSU1_D0514	9.53e-30	124.0	COG3055@1|root,COG3204@1|root,COG3055@2|Bacteria,COG3204@2|Bacteria	2|Bacteria	L	pilus organization	-	-	-	ko:K02674,ko:K07004	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Big_5,Exo_endo_phos,He_PIG,HemolysinCabind,LTD,Laminin_G_3,Malectin,PA14
k59_1624408_1	1278073.MYSTI_05966	3.97e-44	160.0	COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,42R4U@68525|delta/epsilon subdivisions,2X799@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K08082	ko02020,map02020	M00493	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	His_kinase
k59_1402522_1	1123229.AUBC01000005_gene781	2.96e-05	51.6	COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,2TR2H@28211|Alphaproteobacteria,3JU46@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_846175_1	1123269.NX02_02175	1.4e-78	247.0	28JPA@1|root,2Z9FC@2|Bacteria,1PN1F@1224|Proteobacteria,2TSKX@28211|Alphaproteobacteria,2KC8M@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_401903_1	570967.JMLV01000002_gene1505	4.26e-86	260.0	COG1741@1|root,COG1741@2|Bacteria,1MVSW@1224|Proteobacteria,2TSR6@28211|Alphaproteobacteria,2JRVG@204441|Rhodospirillales	204441|Rhodospirillales	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin
k59_1068956_1	1144275.COCOR_01635	5.56e-41	144.0	COG3361@1|root,COG3361@2|Bacteria	2|Bacteria	S	conserved protein (COG2071)	-	-	-	ko:K09166	-	-	-	-	ko00000	-	-	-	DUF2071
k59_1068958_1	713586.KB900536_gene612	9.99e-99	311.0	COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,1RM9A@1236|Gammaproteobacteria,1WWP6@135613|Chromatiales	135613|Chromatiales	D	DNA segregation ATPase FtsK SpoIIIE	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
k59_1237088_1	500637.PROVRUST_07644	4.64e-08	57.8	COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,1S3YV@1236|Gammaproteobacteria,3Z8VE@586|Providencia	1236|Gammaproteobacteria	K	Belongs to the UPF0301 (AlgH) family	yqgE	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
k59_1680471_1	264198.Reut_A0834	5.54e-35	132.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VNZF@28216|Betaproteobacteria,1K34S@119060|Burkholderiaceae	28216|Betaproteobacteria	C	L-carnitine dehydratase bile acid-inducible protein F	caiB	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_1305012_1	1459636.NTE_02670	1.32e-28	116.0	arCOG09395@1|root,arCOG12828@1|root,arCOG09395@2157|Archaea,arCOG12828@2157|Archaea,41T04@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Protein of unknown function (DUF3179)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3179
k59_1193594_1	1238182.C882_3070	5.88e-47	167.0	COG4784@1|root,COG4784@2|Bacteria,1QTT7@1224|Proteobacteria,2TTU7@28211|Alphaproteobacteria,2JQHE@204441|Rhodospirillales	204441|Rhodospirillales	S	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	LysM,Peptidase_M48
k59_1305016_1	1208583.COMX_09884	1.39e-90	275.0	COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,2TQSV@28211|Alphaproteobacteria,2JQII@204441|Rhodospirillales	204441|Rhodospirillales	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
k59_359123_1	760192.Halhy_1321	2.29e-30	122.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,4NHS5@976|Bacteroidetes,1IVS2@117747|Sphingobacteriia	976|Bacteroidetes	EU	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
k59_1360505_1	234267.Acid_4328	9.45e-08	60.1	COG1361@1|root,COG1361@2|Bacteria	2|Bacteria	M	extracellular matrix structural constituent	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter,DUF11
k59_415223_1	2045.KR76_26615	3.65e-09	63.5	COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria,4DPSD@85009|Propionibacteriales	201174|Actinobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_1582734_1	886293.Sinac_1249	7.85e-61	214.0	COG3459@1|root,COG3459@2|Bacteria,2IYJ0@203682|Planctomycetes	203682|Planctomycetes	G	Putative glucoamylase	-	-	-	ko:K13688	-	-	-	-	ko00000,ko01000,ko01003	-	GH94,GT84	-	Glyco_hydro_36,Glyco_transf_36,Glycoamylase
k59_1193605_1	1131814.JAFO01000001_gene3477	5.09e-111	330.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQQJ@28211|Alphaproteobacteria,3EY3A@335928|Xanthobacteraceae	28211|Alphaproteobacteria	E	ATPases associated with a variety of cellular activities	-	-	3.6.3.20	ko:K05816,ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00198,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.1,3.A.1.1.3	-	-	ABC_tran,TOBE_2
k59_971801_1	66897.DJ64_04985	1.96e-60	199.0	COG0566@1|root,COG0566@2|Bacteria,2GJ7P@201174|Actinobacteria	201174|Actinobacteria	J	SpoU rRNA Methylase family	tsnR	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase
k59_1694555_1	1385519.N801_01225	8.99e-59	187.0	COG1670@1|root,COG1670@2|Bacteria	2|Bacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	yokL3	-	2.3.1.57	ko:K00657,ko:K07023	ko00330,ko01100,ko04216,map00330,map01100,map04216	M00135	R01154	RC00004,RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_3
k59_971802_1	1033802.SSPSH_000605	1.79e-38	142.0	COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,1RMM1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009451,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
k59_1694559_1	1128421.JAGA01000002_gene1080	7.78e-86	266.0	COG2133@1|root,COG2133@2|Bacteria,2NNSP@2323|unclassified Bacteria	2|Bacteria	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	CBM_2,GSDH
k59_1748712_1	413816.BBJP01000017_gene1209	0.000535	44.3	COG1917@1|root,arCOG03002@2157|Archaea,2XY21@28890|Euryarchaeota,23W3U@183963|Halobacteria	183963|Halobacteria	S	Cupin 2 conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_192428_1	1198232.CYCME_0083	1.31e-21	100.0	COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,1RPFM@1236|Gammaproteobacteria,45ZVU@72273|Thiotrichales	72273|Thiotrichales	M	PFAM AsmA family	-	-	-	ko:K07289	-	-	-	-	ko00000	-	-	-	AsmA
k59_804472_1	1189612.A33Q_1924	6.28e-71	223.0	2BZ6M@1|root,2Z7HW@2|Bacteria,4NDZE@976|Bacteroidetes,47M8V@768503|Cytophagia	976|Bacteroidetes	S	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
k59_192429_1	234267.Acid_4535	3.03e-41	155.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y6A7@57723|Acidobacteria	57723|Acidobacteria	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Pkinase
k59_1748713_1	1089544.KB912942_gene1537	8.83e-151	431.0	COG2801@1|root,COG2801@2|Bacteria	2|Bacteria	L	transposition	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_23,HTH_28,HTH_32,rve,rve_3
k59_693813_1	1283300.ATXB01000001_gene1637	5.62e-47	158.0	COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,1S1ZB@1236|Gammaproteobacteria,1XE78@135618|Methylococcales	135618|Methylococcales	O	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine	aat	-	2.3.2.6	ko:K00684	-	-	R03813,R11443,R11444	RC00055,RC00064	ko00000,ko01000	-	-	-	Leu_Phe_trans
k59_1250894_1	525904.Tter_1711	4.96e-101	301.0	COG1089@1|root,COG1089@2|Bacteria,2NNM2@2323|unclassified Bacteria	2|Bacteria	M	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose	gmd	-	4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R00888	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
k59_1305075_2	926569.ANT_23640	5.71e-13	71.2	COG2114@1|root,COG2203@1|root,COG5002@1|root,COG2114@2|Bacteria,COG2203@2|Bacteria,COG5002@2|Bacteria,2G6X8@200795|Chloroflexi	200795|Chloroflexi	T	adenylyl cyclase class-3 4 guanylyl cyclase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	FHA,GAF_2,GAF_3,Guanylate_cyc,PAS
k59_971845_1	237368.SCABRO_01666	3.5e-55	184.0	COG0189@1|root,COG0189@2|Bacteria,2J3TZ@203682|Planctomycetes	203682|Planctomycetes	H	Prokaryotic glutathione synthetase, N-terminal domain	-	-	6.3.2.3	ko:K01920	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00497,R10994	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	GSH-S_ATP,GSH-S_N
k59_748848_1	1347368.HG964406_gene6295	3.69e-52	177.0	COG0520@1|root,COG0520@2|Bacteria,1TQ1W@1239|Firmicutes,4HA6Z@91061|Bacilli,1ZB79@1386|Bacillus	91061|Bacilli	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	sufS	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
k59_804507_1	298653.Franean1_2114	2.58e-27	114.0	COG1253@1|root,COG1253@2|Bacteria,2GIWR@201174|Actinobacteria,4ERRK@85013|Frankiales	201174|Actinobacteria	S	CBS domain containing protein	corC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
k59_26210_1	1027292.HMPREF9372_0163	2.86e-46	172.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1TPTQ@1239|Firmicutes,4HCHN@91061|Bacilli,26EEA@186818|Planococcaceae	91061|Bacilli	C	CoA binding domain	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
k59_1472038_1	648996.Theam_0171	2.12e-108	329.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,2G3NT@200783|Aquificae	200783|Aquificae	F	Catalyzes the synthesis of GMP from XMP	guaA	GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
k59_1138700_1	926569.ANT_14470	1e-75	250.0	COG1529@1|root,COG2080@1|root,COG1529@2|Bacteria,COG2080@2|Bacteria,2G5NF@200795|Chloroflexi	200795|Chloroflexi	C	COGs COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs	xdh	-	-	ko:K12528	ko00450,map00450	-	R07229	RC02420	ko00000,ko00001	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2
k59_1138700_2	411468.CLOSCI_01172	2.98e-10	60.8	COG1227@1|root,COG1227@2|Bacteria,1TPH6@1239|Firmicutes,248RQ@186801|Clostridia,21XFF@1506553|Lachnoclostridium	186801|Clostridia	C	DRTGG domain protein	ppaC	-	3.6.1.1	ko:K15986	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	CBS,DHH,DHHA2,DRTGG
k59_693866_2	98439.AJLL01000023_gene758	2.58e-59	196.0	COG0598@1|root,COG0598@2|Bacteria,1G1AG@1117|Cyanobacteria,1JJMP@1189|Stigonemataceae	1117|Cyanobacteria	P	CorA-like Mg2+ transporter protein	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
k59_192495_1	42256.RradSPS_2217	6.7e-65	200.0	COG0229@1|root,COG0229@2|Bacteria,2IHV0@201174|Actinobacteria,4CQBG@84995|Rubrobacteria	84995|Rubrobacteria	O	Belongs to the MsrB Met sulfoxide reductase family	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
k59_26220_1	861299.J421_4436	1.42e-67	230.0	COG2866@1|root,COG2866@2|Bacteria,1ZSMP@142182|Gemmatimonadetes	2|Bacteria	E	Zinc carboxypeptidase	-	-	-	ko:K14054	-	-	-	-	ko00000	-	-	-	AstE_AspA,Peptidase_M14
k59_1415838_1	1131451.O1K_13641	5.69e-54	191.0	COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,1RSNV@1236|Gammaproteobacteria,1X46E@135614|Xanthomonadales	135614|Xanthomonadales	L	Helicase	lhr1	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
k59_748882_1	743299.Acife_2449	2.93e-07	56.2	COG0586@1|root,COG0586@2|Bacteria,1MX4M@1224|Proteobacteria,1RPB1@1236|Gammaproteobacteria,2NCA8@225057|Acidithiobacillales	225057|Acidithiobacillales	P	SNARE associated Golgi protein	-	-	-	ko:K03975	-	-	-	-	ko00000	-	-	-	SNARE_assoc
k59_248148_1	1232443.BAIA02000155_gene1758	5.37e-38	143.0	COG2233@1|root,COG2233@2|Bacteria,1TNZZ@1239|Firmicutes,25CEM@186801|Clostridia	186801|Clostridia	F	Psort location CytoplasmicMembrane, score 10.00	-	-	-	ko:K03458	-	-	-	-	ko00000	2.A.40	-	-	Xan_ur_permease
k59_526504_1	926569.ANT_15270	1.9e-53	188.0	COG1200@1|root,COG1200@2|Bacteria,2G5YM@200795|Chloroflexi	200795|Chloroflexi	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
k59_1140462_1	502025.Hoch_6092	1.23e-63	205.0	COG0005@1|root,COG0005@2|Bacteria,1MUWW@1224|Proteobacteria,42P3C@68525|delta/epsilon subdivisions,2WJW1@28221|Deltaproteobacteria,2YUUB@29|Myxococcales	28221|Deltaproteobacteria	F	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate	punA	-	2.4.2.1	ko:K03783	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
k59_1696457_1	1120948.KB903225_gene5521	9.02e-21	84.3	COG3383@1|root,COG3383@2|Bacteria,2GWFF@201174|Actinobacteria,4ECIK@85010|Pseudonocardiales	201174|Actinobacteria	C	Molybdopterin oxidoreductase	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdopterin
k59_1696457_2	1122611.KB903977_gene2806	4.79e-106	325.0	COG3383@1|root,COG3383@2|Bacteria,2HC9H@201174|Actinobacteria,4EGXK@85012|Streptosporangiales	201174|Actinobacteria	C	Molybdopterin oxidoreductase	fdnG	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdopterin,Molydop_binding
k59_474141_1	378806.STAUR_1721	1.4e-38	143.0	COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,42NGU@68525|delta/epsilon subdivisions,2WIM5@28221|Deltaproteobacteria,2YUZF@29|Myxococcales	28221|Deltaproteobacteria	H	Involved in the biosynthesis of porphyrin-containing compound	hemN	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
k59_1252644_1	330214.NIDE0686	2.63e-41	155.0	COG0784@1|root,COG2203@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,3J10H@40117|Nitrospirae	2|Bacteria	T	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,MEDS,PAS_4,PAS_9,Response_reg
k59_1584593_1	536019.Mesop_6550	1.07e-60	197.0	COG1260@1|root,COG1260@2|Bacteria,1N0D9@1224|Proteobacteria,2TSH8@28211|Alphaproteobacteria,43MYJ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	I	Myo-inositol-1-phosphate synthase	-	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth
k59_1473826_1	1189612.A33Q_0190	2.01e-66	226.0	COG4447@1|root,COG4447@2|Bacteria,4NESU@976|Bacteroidetes,47M5A@768503|Cytophagia	976|Bacteroidetes	S	Sortilin, neurotensin receptor 3,	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
k59_83494_1	1254432.SCE1572_39760	1.89e-06	48.9	COG1260@1|root,COG1260@2|Bacteria,1N0D9@1224|Proteobacteria,42NWK@68525|delta/epsilon subdivisions,2WM2T@28221|Deltaproteobacteria,2YYFZ@29|Myxococcales	28221|Deltaproteobacteria	I	synthase	-	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth,NAD_binding_5
k59_83494_2	742823.HMPREF9465_01983	2.45e-07	53.5	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2VH8J@28216|Betaproteobacteria,4PQ5Y@995019|Sutterellaceae	28216|Betaproteobacteria	P	Heavy-metal-associated domain	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase,YHS
k59_83494_3	388051.AUFE01000011_gene5398	6.14e-12	68.2	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2VH8J@28216|Betaproteobacteria,1K311@119060|Burkholderiaceae	28216|Betaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	copA	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
k59_1584596_1	68199.JNZO01000014_gene3678	8.07e-40	150.0	COG3387@1|root,COG3387@2|Bacteria,2GJAD@201174|Actinobacteria	201174|Actinobacteria	G	Glycoside hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_15
k59_1417550_1	1449347.JQLN01000007_gene2108	2.6e-54	183.0	COG0501@1|root,COG0501@2|Bacteria,2GKJQ@201174|Actinobacteria,2M0BB@2063|Kitasatospora	201174|Actinobacteria	O	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
k59_194444_1	1128421.JAGA01000001_gene2435	5.84e-37	137.0	COG1814@1|root,COG1814@2|Bacteria,2NPJP@2323|unclassified Bacteria	2|Bacteria	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin,VIT1
k59_919225_1	1394178.AWOO02000038_gene9068	5.43e-11	63.2	COG1136@1|root,COG1136@2|Bacteria,2GK3I@201174|Actinobacteria,4EMMN@85012|Streptosporangiales	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_919225_2	506534.Rhein_3508	3.11e-17	83.2	COG0577@1|root,COG0577@2|Bacteria,1QSVW@1224|Proteobacteria,1RPBM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	ABC-type antimicrobial peptide transport system, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_1252678_1	595460.RRSWK_05493	2.08e-28	113.0	COG1212@1|root,COG1212@2|Bacteria,2IYWF@203682|Planctomycetes	203682|Planctomycetes	H	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria	kdsB	-	2.7.7.38	ko:K00979	ko00540,ko01100,map00540,map01100	M00063	R03351,R11396	RC00152,RC00910	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_3
k59_1696498_1	1246995.AFR_40125	6.64e-79	253.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,2GKXV@201174|Actinobacteria,4D8SC@85008|Micromonosporales	201174|Actinobacteria	C	ferredoxin oxidoreductase	porA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
k59_249866_1	1250232.JQNJ01000001_gene3806	6.51e-58	203.0	COG0745@1|root,COG2114@1|root,COG5002@1|root,COG0745@2|Bacteria,COG2114@2|Bacteria,COG5002@2|Bacteria,4P0IA@976|Bacteroidetes,1I039@117743|Flavobacteriia	976|Bacteroidetes	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,Guanylate_cyc,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg,TPR_12
k59_1584617_1	2340.JV46_05690	1.41e-84	259.0	COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,1RN7B@1236|Gammaproteobacteria,1JBRQ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	L COG2826 Transposase and inactivated derivatives, IS30 family	insI	GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004803,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006310,GO:0006313,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0030983,GO:0032135,GO:0032196,GO:0032991,GO:0032993,GO:0034641,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363	-	ko:K07482	-	-	-	-	ko00000	-	-	-	HTH_38,rve
k59_1195521_1	1122132.AQYH01000010_gene4085	1.88e-62	218.0	COG3164@1|root,COG3164@2|Bacteria,1MVDY@1224|Proteobacteria,2TSGG@28211|Alphaproteobacteria,4B6YY@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function	MA20_30770	-	-	-	-	-	-	-	-	-	-	-	AsmA_2,DUF3971
k59_528276_1	479434.Sthe_2324	7.88e-95	288.0	COG0407@1|root,COG0407@2|Bacteria,2G5NU@200795|Chloroflexi,27XWH@189775|Thermomicrobia	189775|Thermomicrobia	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
k59_1362389_2	483219.LILAB_03780	5.95e-18	80.9	COG1145@1|root,32UJ7@2|Bacteria,1R36Z@1224|Proteobacteria	1224|Proteobacteria	C	Ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_417060_1	667014.Thein_0750	2.97e-32	121.0	COG0558@1|root,COG0558@2|Bacteria,2GH4T@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
k59_860527_2	502025.Hoch_5119	1.98e-20	93.2	COG0155@1|root,COG0155@2|Bacteria,1MVVB@1224|Proteobacteria,42Q77@68525|delta/epsilon subdivisions,2WK3N@28221|Deltaproteobacteria,2YU8G@29|Myxococcales	28221|Deltaproteobacteria	C	Sulfite reductase	-	-	1.7.7.1,1.8.1.2,1.8.7.1	ko:K00366,ko:K00381,ko:K00392	ko00910,ko00920,ko01100,ko01120,map00910,map00920,map01100,map01120	M00176,M00531	R00790,R00858,R00859,R03600	RC00065,RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
k59_361022_1	316274.Haur_0787	9.74e-43	159.0	COG1187@1|root,COG1187@2|Bacteria,2G6HU@200795|Chloroflexi,375DQ@32061|Chloroflexia	32061|Chloroflexia	J	Belongs to the pseudouridine synthase RsuA family	-	-	5.4.99.22	ko:K06178	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
k59_638479_1	941824.TCEL_02147	7.04e-35	133.0	COG1207@1|root,COG1207@2|Bacteria,1TP88@1239|Firmicutes,248Z3@186801|Clostridia,36EN8@31979|Clostridiaceae	186801|Clostridia	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2,NTP_transf_3,NTP_transferase
k59_1696523_1	1144275.COCOR_04467	4.05e-58	188.0	COG3335@1|root,COG3335@2|Bacteria	2|Bacteria	L	DDE superfamily endonuclease	-	-	-	ko:K07494	-	-	-	-	ko00000	-	-	-	DDE_3,HTH_23,HTH_32,HTH_33
k59_919261_2	1347087.CBYO010000009_gene1389	4.71e-20	85.9	COG1695@1|root,COG1695@2|Bacteria,1VANP@1239|Firmicutes,4HM54@91061|Bacilli	91061|Bacilli	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
k59_474222_2	1187851.A33M_2428	2.08e-11	66.6	COG1028@1|root,COG1028@2|Bacteria,1P9R4@1224|Proteobacteria,2TTJ5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10,adh_short
k59_750574_1	926566.Terro_1034	2.76e-94	281.0	COG1117@1|root,COG1117@2|Bacteria,3Y35A@57723|Acidobacteria,2JI8F@204432|Acidobacteriia	204432|Acidobacteriia	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
k59_750574_2	671143.DAMO_1099	1.7e-48	169.0	COG0704@1|root,COG1392@1|root,COG0704@2|Bacteria,COG1392@2|Bacteria,2NPPV@2323|unclassified Bacteria	2|Bacteria	P	Protein of unknown function DUF47	phoU	GO:0000287,GO:0001558,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006873,GO:0006950,GO:0007154,GO:0008150,GO:0009266,GO:0009267,GO:0009268,GO:0009405,GO:0009408,GO:0009605,GO:0009628,GO:0009892,GO:0009987,GO:0009991,GO:0010468,GO:0010563,GO:0010605,GO:0010629,GO:0010966,GO:0016020,GO:0016036,GO:0019220,GO:0019222,GO:0019725,GO:0019897,GO:0019898,GO:0022898,GO:0030002,GO:0030145,GO:0030320,GO:0030643,GO:0031323,GO:0031324,GO:0031667,GO:0031668,GO:0031669,GO:0032409,GO:0032410,GO:0032412,GO:0032413,GO:0032879,GO:0033554,GO:0034605,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0040008,GO:0042221,GO:0042592,GO:0042594,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043269,GO:0043271,GO:0044070,GO:0044092,GO:0044419,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045936,GO:0046677,GO:0046872,GO:0046914,GO:0046983,GO:0048519,GO:0048523,GO:0048878,GO:0050789,GO:0050794,GO:0050801,GO:0050896,GO:0051049,GO:0051051,GO:0051128,GO:0051174,GO:0051704,GO:0051716,GO:0055062,GO:0055081,GO:0055082,GO:0055083,GO:0060255,GO:0065007,GO:0065008,GO:0065009,GO:0070887,GO:0071214,GO:0071236,GO:0071467,GO:0071496,GO:0071944,GO:0072501,GO:0072502,GO:0072505,GO:0072506,GO:0098771,GO:0104004,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186	-	ko:K02039,ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU,PhoU_div
k59_361041_1	331869.BAL199_27356	9.52e-106	312.0	COG5285@1|root,COG5285@2|Bacteria,1R6VR@1224|Proteobacteria,2U42H@28211|Alphaproteobacteria,4BQR5@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	Q	Phytanoyl-CoA dioxygenase (PhyH)	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
k59_1750529_1	1121861.KB899949_gene2325	1.64e-57	191.0	COG2828@1|root,COG2828@2|Bacteria,1MXVV@1224|Proteobacteria,2TQMC@28211|Alphaproteobacteria,2JQ10@204441|Rhodospirillales	204441|Rhodospirillales	S	PrpF protein	-	-	-	-	-	-	-	-	-	-	-	-	PrpF
k59_1084438_1	1244869.H261_14395	3.07e-43	152.0	COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,2TVFA@28211|Alphaproteobacteria,2JQEE@204441|Rhodospirillales	204441|Rhodospirillales	S	COG1253 Hemolysins and related proteins containing CBS domains	-	-	-	ko:K06189	-	-	-	-	ko00000,ko02000	9.A.40.1.2	-	-	CBS,CorC_HlyC
k59_1084438_2	985867.AEWF01000002_gene1572	1.66e-18	81.3	COG0319@1|root,COG0319@2|Bacteria,1MZ67@1224|Proteobacteria,2UBXV@28211|Alphaproteobacteria,47FHA@766|Rickettsiales	766|Rickettsiales	J	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	UPF0054
k59_762656_2	331678.Cphamn1_0596	3.38e-09	55.1	COG1826@1|root,COG1826@2|Bacteria,1FE6Y@1090|Chlorobi	1090|Chlorobi	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
k59_873525_1	986075.CathTA2_0197	5.11e-85	268.0	COG0119@1|root,COG0119@2|Bacteria,1TRIK@1239|Firmicutes,4HA3U@91061|Bacilli	91061|Bacilli	E	Belongs to the alpha-IPM synthase homocitrate synthase family	leuA3	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
k59_1375300_1	991905.SL003B_3239	1.99e-09	63.5	COG0790@1|root,COG1196@1|root,COG3409@1|root,COG0790@2|Bacteria,COG1196@2|Bacteria,COG3409@2|Bacteria,1MWPA@1224|Proteobacteria,2TR2B@28211|Alphaproteobacteria,4BQJ8@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	DM	Putative peptidoglycan binding domain	-	-	-	ko:K07126,ko:K13582	ko04112,map04112	-	-	-	ko00000,ko00001	-	-	-	PG_binding_1,Sel1
k59_595638_1	1432050.IE4771_CH03231	1.95e-70	239.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,2TQZU@28211|Alphaproteobacteria,4B7S1@82115|Rhizobiaceae	28211|Alphaproteobacteria	EF	Belongs to the CarB family	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_1265894_1	1111732.AZOD01000013_gene1987	3.03e-20	92.0	COG0852@1|root,COG0852@2|Bacteria,1MX4B@1224|Proteobacteria,1S2ET@1236|Gammaproteobacteria,1X302@135614|Xanthomonadales	135614|Xanthomonadales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016491,GO:0016651,GO:0016655,GO:0044237,GO:0045333,GO:0050136,GO:0055114	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
k59_595640_1	768706.Desor_2730	5.76e-77	248.0	COG5598@1|root,COG5598@2|Bacteria,1TR30@1239|Firmicutes,24CK1@186801|Clostridia,25ZYG@186807|Peptococcaceae	186801|Clostridia	H	PFAM Trimethylamine methyltransferase (MTTB)	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
k59_1486570_1	713586.KB900536_gene819	1.89e-67	219.0	COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,1RMXH@1236|Gammaproteobacteria,1WW29@135613|Chromatiales	135613|Chromatiales	S	PFAM Uncharacterised protein family UPF0027	rtcB	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
k59_373797_2	649747.HMPREF0083_02050	2.27e-22	88.6	COG1278@1|root,COG1278@2|Bacteria,1VEE0@1239|Firmicutes,4HNJC@91061|Bacilli,26YYK@186822|Paenibacillaceae	91061|Bacilli	K	Cold-shock protein	cspD	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
k59_987059_1	314345.SPV1_13177	3.21e-98	299.0	COG0668@1|root,COG0668@2|Bacteria,1MXD2@1224|Proteobacteria	1224|Proteobacteria	M	mechanosensitive ion channel	ynaI	-	-	ko:K22044	-	-	-	-	ko00000,ko02000	1.A.23.3	-	-	MS_channel
k59_1486574_1	384765.SIAM614_04130	2e-43	151.0	COG2126@1|root,COG2126@2|Bacteria,1MXCS@1224|Proteobacteria,2TWZ9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Ion channel	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2
k59_150733_1	1485545.JQLW01000005_gene923	4.02e-24	100.0	COG1773@1|root,COG1773@2|Bacteria,1N813@1224|Proteobacteria	1224|Proteobacteria	C	hydrogenase	hybE	GO:0003674,GO:0005488,GO:0005515,GO:0006807,GO:0008150,GO:0008152,GO:0010467,GO:0019538,GO:0043170,GO:0044238,GO:0051604,GO:0070678,GO:0071704,GO:1901564	-	-	-	-	-	-	-	-	-	-	NiFe-hyd_HybE,Rubredoxin
k59_818570_1	1336208.JADY01000015_gene1332	1.55e-10	63.2	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,2TTE2@28211|Alphaproteobacteria,2JT2G@204441|Rhodospirillales	204441|Rhodospirillales	C	4Fe-4S dicluster domain	-	-	-	ko:K00124	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Fer4_11,Fer4_7,Form-deh_trans
k59_818570_2	366394.Smed_5489	7.57e-12	68.9	COG2864@1|root,COG2864@2|Bacteria,1MXFQ@1224|Proteobacteria,2TT30@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	formate dehydrogenase	fdnI	-	-	ko:K00127	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Ni_hydr_CYTB
k59_1153022_1	309800.C498_00510	8.66e-49	170.0	COG1914@1|root,arCOG04531@2157|Archaea,2XU6H@28890|Euryarchaeota,23UME@183963|Halobacteria	183963|Halobacteria	P	COG1914 Mn2 and Fe2 transporters of the NRAMP family	mntH2	-	-	ko:K03322	-	-	-	-	ko00000,ko02000	2.A.55.2.6,2.A.55.3	-	-	Nramp
k59_649954_1	926569.ANT_19230	8.7e-06	48.5	COG0681@1|root,COG0681@2|Bacteria,2G701@200795|Chloroflexi	200795|Chloroflexi	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
k59_649954_2	1238182.C882_3594	3.05e-07	53.1	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TRII@28211|Alphaproteobacteria,2JQE7@204441|Rhodospirillales	204441|Rhodospirillales	I	AMP-binding enzyme C-terminal domain	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_1375326_1	483219.LILAB_33840	1.23e-45	168.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_595668_1	1033743.CAES01000033_gene1025	7.42e-68	211.0	COG2818@1|root,COG2818@2|Bacteria,1UYWG@1239|Firmicutes,4HGWW@91061|Bacilli,26TEW@186822|Paenibacillaceae	91061|Bacilli	L	DNA-3-methyladenine glycosylase	tag	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
k59_1650619_1	1379270.AUXF01000002_gene1604	8.69e-13	68.6	294EW@1|root,2ZRUR@2|Bacteria,1ZV2S@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Protein of unknown function (DUF1569)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1569
k59_1265941_1	883126.HMPREF9710_03421	8.95e-46	163.0	COG1680@1|root,COG1680@2|Bacteria,1NHIY@1224|Proteobacteria,2WEEX@28216|Betaproteobacteria,478W4@75682|Oxalobacteraceae	28216|Betaproteobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_487067_1	68170.KL590510_gene7458	2.54e-06	55.8	COG0457@1|root,COG3899@1|root,COG0457@2|Bacteria,COG3899@2|Bacteria,2IBE2@201174|Actinobacteria	2|Bacteria	K	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
k59_319642_1	237368.SCABRO_03837	2.69e-05	47.4	29MQ2@1|root,308MT@2|Bacteria,2J179@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_762708_1	1300350.DSW25_02590	3.1e-20	94.7	COG0277@1|root,COG0277@2|Bacteria,1MVYV@1224|Proteobacteria,2TRA7@28211|Alphaproteobacteria,3ZVK2@60136|Sulfitobacter	28211|Alphaproteobacteria	C	FAD binding domain	glcE	-	-	ko:K11472	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_487077_2	398511.BpOF4_13585	0.00023	44.3	COG1024@1|root,COG1024@2|Bacteria,1TQ2V@1239|Firmicutes,4HBT0@91061|Bacilli,1ZE3C@1386|Bacillus	91061|Bacilli	I	Belongs to the enoyl-CoA hydratase isomerase family	phaB	GO:0003674,GO:0003824,GO:0004300,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006635,GO:0006636,GO:0008150,GO:0008152,GO:0008610,GO:0009056,GO:0009058,GO:0009062,GO:0009987,GO:0016042,GO:0016053,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016860,GO:0016863,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0033559,GO:0034017,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044281,GO:0044282,GO:0044283,GO:0046394,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:0072330,GO:1901575,GO:1901576	5.3.3.14,5.3.3.18	ko:K15866,ko:K18474	ko00061,ko00360,ko01120,map00061,map00360,map01120	-	R07639,R09837,R09839	RC00004,RC00326,RC01078,RC02689,RC03003	ko00000,ko00001,ko01000,ko01004	-	-	-	ECH_1
k59_150786_1	1121875.KB907546_gene2195	3.14e-15	77.4	COG3653@1|root,COG3653@2|Bacteria,4NHDD@976|Bacteroidetes,1I2RR@117743|Flavobacteriia	976|Bacteroidetes	Q	PFAM D-aminoacylase, C-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,Amidohydro_3
k59_1097233_1	857087.Metme_1539	4.91e-22	100.0	COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RQW8@1236|Gammaproteobacteria,1XGZI@135618|Methylococcales	135618|Methylococcales	M	Protein of unknown function (DUF3772)	-	-	-	ko:K05802	-	-	-	-	ko00000,ko02000	1.A.23.1.1	-	-	DUF3772,MS_channel
k59_873585_1	765420.OSCT_2976	5.76e-53	179.0	COG1239@1|root,COG1239@2|Bacteria,2G832@200795|Chloroflexi,3756V@32061|Chloroflexia	32061|Chloroflexia	H	SMART AAA ATPase	-	-	6.6.1.1	ko:K03405	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	-	Mg_chelatase
k59_540522_1	644282.Deba_1961	4.39e-44	160.0	COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,42M3C@68525|delta/epsilon subdivisions,2WJ21@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	rpoN	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
k59_1320591_1	880073.Calab_3508	1.37e-96	295.0	COG1446@1|root,COG1446@2|Bacteria,2NPFC@2323|unclassified Bacteria	2|Bacteria	E	Asparaginase	asnA2	GO:0005575,GO:0005623,GO:0042597,GO:0044464	3.4.19.5,3.5.1.1,3.5.1.26	ko:K01424,ko:K01444,ko:K13051	ko00250,ko00460,ko00511,ko01100,ko01110,ko04142,map00250,map00460,map00511,map01100,map01110,map04142	-	R00485	RC00010,RC02798	ko00000,ko00001,ko01000,ko01002	-	-	-	Asparaginase_2
k59_1153071_1	99598.Cal7507_0722	2.33e-52	178.0	COG4299@1|root,COG4299@2|Bacteria,1G087@1117|Cyanobacteria,1HK21@1161|Nostocales	1117|Cyanobacteria	S	COGs COG4299 conserved	-	-	-	-	-	-	-	-	-	-	-	-	DUF1624,DUF5009
k59_1045514_1	1144310.PMI07_001961	3.21e-33	122.0	COG3836@1|root,COG3836@2|Bacteria,1R9U6@1224|Proteobacteria,2TSTY@28211|Alphaproteobacteria,4B7QE@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Belongs to the HpcH HpaI aldolase family	-	-	-	-	-	-	-	-	-	-	-	-	HpcH_HpaI
k59_651773_1	880070.Cycma_1813	1.15e-75	229.0	COG0229@1|root,COG0229@2|Bacteria,4NQEY@976|Bacteroidetes,47PZ4@768503|Cytophagia	976|Bacteroidetes	O	peptide methionine sulfoxide reductase	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	PMSR,SelR
k59_207132_1	419947.MRA_3340	4e-62	212.0	COG3119@1|root,COG3119@2|Bacteria,2GJ8H@201174|Actinobacteria,233CA@1762|Mycobacteriaceae	201174|Actinobacteria	P	thought to play an important role in the mineralization of sulfates catalytic activity a phenol sulfate H2O a phenol sulfate	atsB	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	DUF1269,Sulfatase
k59_1045517_1	1511.CLOST_2587	3.95e-09	61.6	COG0706@1|root,COG0706@2|Bacteria,1TQ0J@1239|Firmicutes,247V9@186801|Clostridia,25RE0@186804|Peptostreptococcaceae	186801|Clostridia	U	60Kd inner membrane protein	oxaA	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP
k59_263330_2	266940.Krad_2011	1.14e-07	55.1	COG0457@1|root,COG2199@1|root,COG0457@2|Bacteria,COG2199@2|Bacteria,2I2TC@201174|Actinobacteria	201174|Actinobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
k59_820614_2	927658.AJUM01000010_gene1384	2.8e-10	63.5	COG0845@1|root,COG0845@2|Bacteria,4NHJH@976|Bacteroidetes,2FP9C@200643|Bacteroidia	976|Bacteroidetes	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
k59_1542076_1	1366050.N234_37785	4.68e-64	212.0	COG1273@1|root,COG1273@2|Bacteria,1N4UX@1224|Proteobacteria,2VNNN@28216|Betaproteobacteria,1K24Z@119060|Burkholderiaceae	28216|Betaproteobacteria	L	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD	-	-	-	ko:K10979	ko03450,map03450	-	-	-	ko00000,ko00001,ko03400	-	-	-	Ku
k59_1542076_2	1312959.KI914697_gene3142	1.01e-12	68.6	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,2GJPX@201174|Actinobacteria,1W81P@1268|Micrococcaceae	201174|Actinobacteria	L	DNA polymerase Ligase (LigD)	ligD	GO:0000166,GO:0000287,GO:0000726,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0003896,GO:0003899,GO:0003909,GO:0003910,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0004652,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006269,GO:0006281,GO:0006302,GO:0006303,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0008296,GO:0008297,GO:0008310,GO:0008408,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016874,GO:0016886,GO:0016895,GO:0017076,GO:0018130,GO:0019438,GO:0030145,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0033554,GO:0034061,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0070566,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0097747,GO:0140097,GO:0140098,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576	6.5.1.1,6.5.1.6,6.5.1.7	ko:K01971,ko:K10747	ko03030,ko03410,ko03420,ko03430,ko03450,map03030,map03410,map03420,map03430,map03450	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
k59_542492_1	1349822.NSB1T_10945	1.19e-26	107.0	COG1216@1|root,COG1216@2|Bacteria,4PM3U@976|Bacteroidetes,2FP08@200643|Bacteroidia,22X7W@171551|Porphyromonadaceae	976|Bacteroidetes	S	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_542492_2	460265.Mnod_6374	1.39e-27	103.0	COG3952@1|root,COG3952@2|Bacteria,1MZ60@1224|Proteobacteria,2UCCY@28211|Alphaproteobacteria,1JUVB@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	PFAM lipid A biosynthesis domain protein	-	-	-	-	-	-	-	-	-	-	-	-	LAB_N
k59_934934_1	1121940.AUDZ01000007_gene2181	2.55e-21	90.9	2EC16@1|root,3360E@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4373,HTH_36
k59_1599710_1	861299.J421_3522	4.46e-57	199.0	COG0013@1|root,COG0013@2|Bacteria,1ZT18@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
k59_820636_1	382464.ABSI01000012_gene2198	9.19e-18	83.2	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,TPR_11,TPR_16,TPR_7,TPR_8,Trans_reg_C
k59_488982_1	467200.ACFA01000913_gene3389	1.26e-27	111.0	COG1028@1|root,COG1028@2|Bacteria,2GK20@201174|Actinobacteria	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	1.1.1.127	ko:K00065	ko00040,map00040	-	R01542	RC00089	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
k59_207166_2	35754.JNYJ01000007_gene2931	2.94e-50	173.0	COG4177@1|root,COG4177@2|Bacteria,2GMGD@201174|Actinobacteria,4DEZ6@85008|Micromonosporales	201174|Actinobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_1377532_1	469381.Dpep_1804	8.43e-45	161.0	COG3845@1|root,COG3845@2|Bacteria,3TAF4@508458|Synergistetes	508458|Synergistetes	S	PFAM ABC transporter	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
k59_376057_1	570967.JMLV01000014_gene2033	1.43e-50	170.0	COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,2TR5I@28211|Alphaproteobacteria,2JQWN@204441|Rhodospirillales	204441|Rhodospirillales	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GTP1_OBG,MMR_HSR1
k59_376057_2	1112214.AHIS01000063_gene2731	4.63e-07	51.6	COG1670@1|root,COG1670@2|Bacteria,1N6Q1@1224|Proteobacteria,2UG72@28211|Alphaproteobacteria,2K4XG@204457|Sphingomonadales	204457|Sphingomonadales	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
k59_152930_1	1206725.BAFU01000091_gene4729	1.48e-13	75.9	COG0726@1|root,COG0726@2|Bacteria,2GM0X@201174|Actinobacteria,4FXHK@85025|Nocardiaceae	201174|Actinobacteria	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
k59_1377539_1	926569.ANT_15870	2.97e-85	275.0	COG1287@1|root,COG1287@2|Bacteria	2|Bacteria	S	oligosaccharyl transferase activity	-	-	2.4.99.18	ko:K07151	ko00510,ko00513,ko01100,ko04141,map00510,map00513,map01100,map04141	M00072	R04216,R05976	RC00005,RC00482	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT66	-	PMT_2
k59_1712117_2	1229780.BN381_180029	1.19e-13	72.0	COG0628@1|root,COG0628@2|Bacteria,2GN4Y@201174|Actinobacteria	201174|Actinobacteria	S	permease	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
k59_820666_1	63737.Npun_R0954	7.51e-38	145.0	COG2366@1|root,COG2366@2|Bacteria,1G4M5@1117|Cyanobacteria,1HU4F@1161|Nostocales	1117|Cyanobacteria	S	penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
k59_651838_1	572477.Alvin_2314	1.69e-42	152.0	COG0025@1|root,COG0025@2|Bacteria,1MW5T@1224|Proteobacteria,1RPH6@1236|Gammaproteobacteria,1WW2W@135613|Chromatiales	135613|Chromatiales	P	PFAM sodium hydrogen exchanger	-	-	-	ko:K03316	-	-	-	-	ko00000	2.A.36	-	-	Na_H_Exchanger
k59_820668_1	1169152.AXVD01000019_gene835	5.99e-39	144.0	COG0778@1|root,COG0778@2|Bacteria,2H3K6@201174|Actinobacteria	201174|Actinobacteria	C	Putative TM nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
k59_710821_1	1122132.AQYH01000005_gene567	1.46e-122	387.0	COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,2TQJZ@28211|Alphaproteobacteria,4BAHT@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Belongs to the helicase family. UvrD subfamily	addA	-	3.6.4.12	ko:K16898	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
k59_1488959_1	1380380.JIAX01000012_gene438	3.74e-32	121.0	COG0457@1|root,COG0457@2|Bacteria,1N0DE@1224|Proteobacteria,2UCGA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	COG0457 FOG TPR repeat	MA20_05980	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_6,TPR_8
k59_542555_1	1117943.SFHH103_02493	5.79e-13	75.1	COG0515@1|root,COG2203@1|root,COG3899@1|root,COG4191@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQX3@28211|Alphaproteobacteria,4BNVY@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Multi-sensor signal transduction multi-kinase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_8,PAS_9,Pkinase
k59_1542140_1	379066.GAU_1909	8.73e-65	212.0	COG2256@1|root,COG2256@2|Bacteria,1ZTCA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	MgsA AAA+ ATPase C terminal	-	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA_assoc_2,MgsA_C,RuvB_N
k59_152977_1	1121930.AQXG01000003_gene2586	5.46e-68	219.0	COG0282@1|root,COG0282@2|Bacteria,4NFI0@976|Bacteroidetes,1IPB9@117747|Sphingobacteriia	976|Bacteroidetes	C	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
k59_1542150_1	344747.PM8797T_16735	1.61e-53	188.0	COG0501@1|root,COG0501@2|Bacteria,2IXM0@203682|Planctomycetes	203682|Planctomycetes	O	Zn-dependent protease with chaperone function	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
k59_1377593_1	1122176.KB903554_gene3791	9.23e-12	70.9	COG0457@1|root,COG0457@2|Bacteria,4NKQV@976|Bacteroidetes	976|Bacteroidetes	T	Pfam Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1099344_1	484770.UFO1_1595	2.5e-51	175.0	COG3509@1|root,COG3509@2|Bacteria,1TT77@1239|Firmicutes,4H3TQ@909932|Negativicutes	909932|Negativicutes	Q	depolymerase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1542165_1	382464.ABSI01000012_gene2189	6.99e-21	97.4	COG0577@1|root,COG0577@2|Bacteria,46UZM@74201|Verrucomicrobia	74201|Verrucomicrobia	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_1045625_1	1123508.JH636447_gene7918	2.4e-26	105.0	COG0524@1|root,COG0524@2|Bacteria,2IY5G@203682|Planctomycetes	203682|Planctomycetes	G	pfkB family carbohydrate kinase	-	-	2.7.1.45	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00061,M00308,M00631	R01541	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
k59_820729_1	266117.Rxyl_1929	1.15e-54	191.0	COG1067@1|root,COG1067@2|Bacteria,2H2TE@201174|Actinobacteria	201174|Actinobacteria	O	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_32,Lon_C
k59_1045632_1	1123073.KB899241_gene2253	6.53e-55	180.0	COG0132@1|root,COG0132@2|Bacteria,1RDRK@1224|Proteobacteria,1RSHS@1236|Gammaproteobacteria,1X3VC@135614|Xanthomonadales	135614|Xanthomonadales	H	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring	bioD	GO:0003674,GO:0003824,GO:0004141,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.3.3	ko:K01935	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03182	RC00868	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26
k59_542609_2	999547.KI421503_gene73	2.5e-09	59.3	COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,1PBHA@1224|Proteobacteria,2TRQF@28211|Alphaproteobacteria,281ZM@191028|Leisingera	28211|Alphaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,rve,rve_3
k59_1268212_1	1278073.MYSTI_06116	6.92e-95	298.0	COG2993@1|root,COG3278@1|root,COG2993@2|Bacteria,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,42M5M@68525|delta/epsilon subdivisions,2WM27@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Belongs to the heme-copper respiratory oxidase family	-	-	1.9.3.1	ko:K00404,ko:K15862	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	COX1,FixO
k59_1056514_1	1120972.AUMH01000011_gene177	2.57e-44	158.0	COG0618@1|root,COG0618@2|Bacteria,1TPXX@1239|Firmicutes,4H9ZW@91061|Bacilli,2788W@186823|Alicyclobacillaceae	91061|Bacilli	S	DHH family	nrnA	-	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
k59_1056514_2	671143.DAMO_0578	5.83e-61	197.0	COG0130@1|root,COG0130@2|Bacteria,2NP9J@2323|unclassified Bacteria	2|Bacteria	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	GO:0000049,GO:0001522,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0031119,GO:0034337,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990481	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB-C_2,TruB_C_2,TruB_N
k59_945337_1	1298867.AUES01000067_gene5125	9.74e-15	79.3	COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TTJ0@28211|Alphaproteobacteria,3JS5D@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HAMP,HATPase_c,HisKA,PAS_7,dCache_1
k59_167008_1	247633.GP2143_15546	0.000241	48.5	COG2159@1|root,COG2159@2|Bacteria,1N0C7@1224|Proteobacteria,1SDRJ@1236|Gammaproteobacteria,1J73J@118884|unclassified Gammaproteobacteria	1224|Proteobacteria	S	metal-dependent hydrolase of the TIM-barrel fold	MA20_19310	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
k59_1501297_1	1502851.FG93_02747	8.71e-53	178.0	COG0726@1|root,COG0726@2|Bacteria,1MWMZ@1224|Proteobacteria,2TVFK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	DUF3473,Polysacc_deac_1
k59_945365_1	1127696.HMPREF9134_01475	6.11e-81	258.0	COG0402@1|root,COG0402@2|Bacteria,4NHV6@976|Bacteroidetes,2FQSE@200643|Bacteroidia,22XCF@171551|Porphyromonadaceae	976|Bacteroidetes	F	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine	mtaD	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
k59_778586_1	243090.RB2114	6.87e-38	142.0	COG1048@1|root,COG1048@2|Bacteria,2IY29@203682|Planctomycetes	203682|Planctomycetes	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k59_1445729_1	314278.NB231_16468	1.98e-98	306.0	COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,1RP6F@1236|Gammaproteobacteria,1WX62@135613|Chromatiales	135613|Chromatiales	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
k59_279_1	1380394.JADL01000013_gene597	8.69e-08	53.9	COG0028@1|root,COG0028@2|Bacteria,1MX3Q@1224|Proteobacteria,2U2RW@28211|Alphaproteobacteria,2JVNM@204441|Rhodospirillales	204441|Rhodospirillales	EH	Thiamine pyrophosphate enzyme, central domain	-	-	-	-	-	-	-	-	-	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_279_2	1463857.JOFZ01000007_gene163	5.05e-13	71.6	COG0043@1|root,COG0043@2|Bacteria,2GKSI@201174|Actinobacteria	201174|Actinobacteria	H	Belongs to the UbiD family	-	-	-	-	-	-	-	-	-	-	-	-	UbiD
k59_556195_1	1280671.AUJH01000032_gene22	2.22e-14	77.8	COG3250@1|root,COG3250@2|Bacteria,1TPK7@1239|Firmicutes,247VE@186801|Clostridia,4BWFE@830|Butyrivibrio	186801|Clostridia	G	Domain of unknown function (DUF4982)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
k59_1445739_1	161934.XP_010694245.1	9.61e-23	99.8	COG0237@1|root,KOG3220@2759|Eukaryota,37RNA@33090|Viridiplantae,3G96N@35493|Streptophyta	35493|Streptophyta	H	dephospho-CoA kinase	-	GO:0003674,GO:0003824,GO:0004140,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005773,GO:0005777,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009507,GO:0009536,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE
k59_222649_1	1403819.BATR01000027_gene881	1.87e-61	201.0	COG4948@1|root,COG4948@2|Bacteria,46VZI@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
k59_111479_1	644966.Tmar_1206	4.58e-17	81.3	COG2064@1|root,COG2064@2|Bacteria,1V2T1@1239|Firmicutes,24GQ4@186801|Clostridia,3WDAP@538999|Clostridiales incertae sedis	186801|Clostridia	NU	PFAM Bacterial type II secretion system protein F domain	tadC	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
k59_111479_2	194439.CT0431.1	0.00022	45.4	COG4961@1|root,COG4961@2|Bacteria,1FECW@1090|Chlorobi	1090|Chlorobi	U	Putative Flp pilus-assembly TadE/G-like	-	-	-	-	-	-	-	-	-	-	-	-	Tad_C
k59_1556921_1	1123229.AUBC01000025_gene4463	3.01e-60	196.0	COG0834@1|root,COG0834@2|Bacteria,1MV5D@1224|Proteobacteria,2TTXX@28211|Alphaproteobacteria,3JRKX@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	ET	Bacterial periplasmic substrate-binding proteins	gltI	-	-	ko:K02030,ko:K10001	ko02010,ko02020,map02010,map02020	M00230,M00236	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3,3.A.1.3.19,3.A.1.3.4	-	-	SBP_bac_3
k59_834195_1	1121930.AQXG01000002_gene2287	1.67e-12	67.4	COG1940@1|root,COG1940@2|Bacteria,4NJ71@976|Bacteroidetes,1IS5A@117747|Sphingobacteriia	976|Bacteroidetes	GK	ROK family	-	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
k59_1056788_1	1100720.ALKN01000034_gene543	9.31e-56	186.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2VM9J@28216|Betaproteobacteria,4AAZ2@80864|Comamonadaceae	28216|Betaproteobacteria	I	Thiolase, C-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_334039_1	1121864.OMO_00720	0.000209	43.9	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,4HAA6@91061|Bacilli,4B0JC@81852|Enterococcaceae	91061|Bacilli	IQ	Enoyl-(Acyl carrier protein) reductase	fabG	GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iYO844.BSU15910	adh_short_C2
k59_334039_2	1229204.AMYY01000002_gene2614	4.11e-18	87.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TSB1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EH	Belongs to the TPP enzyme family	MA20_27780	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_111712_1	1042375.AFPL01000034_gene3097	3.42e-61	207.0	COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,1RNGV@1236|Gammaproteobacteria,4644T@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009314,GO:0009380,GO:0009381,GO:0009628,GO:0009987,GO:0016787,GO:0016788,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH,HHH_2,HHH_5,UVR,UvrC_HhH_N
k59_56103_1	1307761.L21SP2_0743	3.88e-36	133.0	COG1840@1|root,COG1840@2|Bacteria	2|Bacteria	P	iron ion homeostasis	futA1	GO:0005575,GO:0005623,GO:0042597,GO:0044464	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	iJN678.sufA	SBP_bac_6,SBP_bac_8
k59_1723925_1	926569.ANT_19400	3.1e-85	258.0	COG2386@1|root,COG2386@2|Bacteria,2G6TN@200795|Chloroflexi	200795|Chloroflexi	O	PFAM cytochrome c-type biogenesis protein CcmB	ccmB	-	-	ko:K02194	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	CcmB
k59_1723925_2	926569.ANT_19410	5.37e-32	118.0	COG1131@1|root,COG1131@2|Bacteria,2G6IS@200795|Chloroflexi	200795|Chloroflexi	V	PFAM ABC transporter related	ccmA	-	3.6.3.41	ko:K02193	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.107	-	-	ABC_tran
k59_1223621_1	1300345.LF41_1080	2.98e-52	181.0	COG0457@1|root,COG0457@2|Bacteria,1N0A9@1224|Proteobacteria,1RZSZ@1236|Gammaproteobacteria,1XA6G@135614|Xanthomonadales	135614|Xanthomonadales	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1446005_1	281687.CJA15737	1.36e-09	58.5	COG0156@1|root,KOG1359@2759|Eukaryota,39JFM@33154|Opisthokonta,3BC5W@33208|Metazoa,3CRY7@33213|Bilateria,40CD1@6231|Nematoda,1KTYJ@119089|Chromadorea,40VS8@6236|Rhabditida	33208|Metazoa	E	Aminotransferase class I and II	GCAT	GO:0001653,GO:0003674,GO:0003824,GO:0004888,GO:0004930,GO:0004966,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005886,GO:0005887,GO:0005929,GO:0006082,GO:0006355,GO:0006357,GO:0006520,GO:0006807,GO:0007154,GO:0007165,GO:0007186,GO:0007187,GO:0007188,GO:0007200,GO:0007218,GO:0008150,GO:0008152,GO:0008188,GO:0008528,GO:0008890,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016021,GO:0016407,GO:0016408,GO:0016453,GO:0016604,GO:0016607,GO:0016740,GO:0016746,GO:0016747,GO:0017046,GO:0019219,GO:0019222,GO:0019752,GO:0019866,GO:0023052,GO:0031090,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0031981,GO:0033218,GO:0038023,GO:0042277,GO:0042562,GO:0042995,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044451,GO:0044459,GO:0044464,GO:0045893,GO:0045935,GO:0045944,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060089,GO:0060255,GO:0065007,GO:0070013,GO:0071704,GO:0071944,GO:0080090,GO:0090663,GO:0097730,GO:0120025,GO:1901564,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_1446005_2	448385.sce8189	1.88e-54	177.0	COG0036@1|root,COG0036@2|Bacteria,1MUZM@1224|Proteobacteria,42NC0@68525|delta/epsilon subdivisions,2WJK9@28221|Deltaproteobacteria,2YURC@29|Myxococcales	28221|Deltaproteobacteria	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
k59_1557170_1	991905.SL003B_0184	2.33e-31	116.0	COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,2TQYF@28211|Alphaproteobacteria,4BPBJ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family	sdhB	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_10,Fer4_17,Fer4_8
k59_1557170_2	1122604.JONR01000005_gene937	2.27e-13	66.6	COG2938@1|root,COG2938@2|Bacteria,1N7P4@1224|Proteobacteria,1SCKB@1236|Gammaproteobacteria,1X8R6@135614|Xanthomonadales	135614|Xanthomonadales	S	Flavinator of succinate dehydrogenase	-	-	-	ko:K09159	-	-	-	-	ko00000,ko02048	-	-	-	Sdh5
k59_1390388_1	765420.OSCT_2652	1e-36	135.0	COG0655@1|root,COG0655@2|Bacteria	2|Bacteria	S	NAD(P)H dehydrogenase (quinone) activity	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
k59_1390388_2	324925.Ppha_0758	1.65e-21	91.3	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	-	GO:0003674,GO:0003700,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2001141	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_1112471_1	521674.Plim_2958	1.07e-23	100.0	COG1622@1|root,COG1622@2|Bacteria,2IZBI@203682|Planctomycetes	203682|Planctomycetes	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM
k59_167318_1	1049564.TevJSym_ac00650	4.58e-07	56.6	COG0589@1|root,COG0589@2|Bacteria	2|Bacteria	T	AMP binding	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_500873_1	929562.Emtol_4237	8.28e-48	172.0	COG0308@1|root,COG0308@2|Bacteria,4NE13@976|Bacteroidetes,47K4C@768503|Cytophagia	976|Bacteroidetes	E	Peptidase family M1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
k59_1723957_1	1192034.CAP_1171	9.86e-66	224.0	COG0243@1|root,COG0437@1|root,COG0243@2|Bacteria,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42NEG@68525|delta/epsilon subdivisions,2WKHA@28221|Deltaproteobacteria,2YTUQ@29|Myxococcales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	actB	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_111762_1	319225.Plut_2078	9.52e-13	65.5	COG1917@1|root,COG1917@2|Bacteria	2|Bacteria	L	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,AraC_binding,Cupin_2
k59_111762_2	1227454.C446_17766	1.62e-32	127.0	COG0733@1|root,arCOG04466@2157|Archaea,2XUK4@28890|Euryarchaeota,23UHD@183963|Halobacteria	183963|Halobacteria	P	COG0733 Na -dependent transporters of the SNF family	-	-	-	ko:K03308	-	-	-	-	ko00000	2.A.22.4,2.A.22.5	-	-	SNF
k59_612095_1	1265505.ATUG01000001_gene3625	2.17e-71	222.0	COG0745@1|root,COG0745@2|Bacteria,1MU3A@1224|Proteobacteria,42S73@68525|delta/epsilon subdivisions,2WNPE@28221|Deltaproteobacteria,2MPTJ@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
k59_572_1	1009370.ALO_08138	3.7e-24	104.0	COG0683@1|root,COG0683@2|Bacteria,1V4XA@1239|Firmicutes	1239|Firmicutes	E	ABC-type branched-chain amino acid transport	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_445324_1	247633.GP2143_14606	2.61e-05	51.6	COG3245@1|root,COG4993@1|root,COG3245@2|Bacteria,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,1RN5D@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3,PQQ,PQQ_2
k59_278514_1	926549.KI421517_gene700	1.15e-87	293.0	COG4888@1|root,COG4888@2|Bacteria,4NEE8@976|Bacteroidetes,47JJ5@768503|Cytophagia	976|Bacteroidetes	S	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
k59_1612779_1	1117958.PE143B_0129240	4.91e-79	250.0	COG3567@1|root,COG3567@2|Bacteria,1QNPU@1224|Proteobacteria,1S4PU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1073)	-	-	-	ko:K09961	-	-	-	-	ko00000	-	-	-	DUF1073
k59_1612779_2	1127518.H9C105_9CAUD	4.91e-26	107.0	4QE7S@10239|Viruses,4QVMZ@35237|dsDNA viruses  no RNA stage,4QSDX@28883|Caudovirales,4QKF5@10662|Myoviridae	10662|Myoviridae	S	Phage terminase large subunit	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_778899_2	570967.JMLV01000002_gene1978	0.000279	42.4	COG3618@1|root,COG3618@2|Bacteria,1N2QM@1224|Proteobacteria,2TTZK@28211|Alphaproteobacteria,2JS33@204441|Rhodospirillales	204441|Rhodospirillales	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
k59_834499_1	1120950.KB892775_gene1183	7.66e-37	137.0	COG1055@1|root,COG1055@2|Bacteria,2GMQJ@201174|Actinobacteria,4DN5A@85009|Propionibacteriales	201174|Actinobacteria	P	Bacterial Na+/H+ antiporter B (NhaB)	arsA	-	-	ko:K03893	-	-	-	-	ko00000,ko02000	2.A.45.1,3.A.4.1	-	-	ArsB,CitMHS
k59_1168073_1	1121374.KB891583_gene2884	1.67e-112	338.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,1RR2W@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	COG3666 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_723356_1	580327.Tthe_0382	1.24e-69	220.0	COG0294@1|root,COG0294@2|Bacteria,1TPKT@1239|Firmicutes,248BE@186801|Clostridia,42FAT@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS03115	Pterin_bind
k59_1279268_1	398767.Glov_3268	8.8e-10	66.6	COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria	1224|Proteobacteria	C	protein containing LysM domain	lysM	-	-	-	-	-	-	-	-	-	-	-	LysM
k59_111794_2	521674.Plim_0173	4.29e-15	75.9	COG0712@1|root,COG0712@2|Bacteria,2J09A@203682|Planctomycetes	203682|Planctomycetes	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
k59_556515_1	1128421.JAGA01000002_gene79	4.88e-33	131.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,2NNXI@2323|unclassified Bacteria	2|Bacteria	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iG2583_1286.G2583_2160,iPC815.YPO2428	B3_4,B5,FDX-ACB,tRNA_bind
k59_1001317_1	1112217.PPL19_21621	8.48e-79	248.0	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,1RNHY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	GO:0006457,GO:0008150,GO:0009987	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
k59_1001334_1	314278.NB231_01239	2.28e-15	81.3	COG5659@1|root,COG5659@2|Bacteria,1MWAV@1224|Proteobacteria,1S12Y@1236|Gammaproteobacteria,1X271@135613|Chromatiales	135613|Chromatiales	L	COG5659 FOG Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
k59_445392_1	395965.Msil_2983	2.46e-23	102.0	COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,2TQSW@28211|Alphaproteobacteria,3NA1Z@45404|Beijerinckiaceae	28211|Alphaproteobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
k59_612168_2	114615.BRADO0033	1.35e-52	175.0	COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,2TQZX@28211|Alphaproteobacteria,3JT4N@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	Tryptophanyl-tRNA synthetase	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
k59_556561_1	700598.Niako_3170	1.02e-13	76.6	COG0577@1|root,COG0577@2|Bacteria,4NDUK@976|Bacteroidetes,1INSB@117747|Sphingobacteriia	976|Bacteroidetes	V	TIGRFAM Acidobacterial duplicated orphan permease	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_500978_1	311424.DhcVS_311	3.99e-86	258.0	COG0221@1|root,COG0221@2|Bacteria,2G6T4@200795|Chloroflexi,34CZD@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions	ppa	-	3.6.1.1	ko:K01507	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyrophosphatase
k59_834566_1	234267.Acid_3032	2.36e-36	132.0	COG1309@1|root,COG1309@2|Bacteria,3Y4KN@57723|Acidobacteria	57723|Acidobacteria	K	regulatory protein TetR	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_223007_2	526227.Mesil_2106	1.17e-06	50.4	COG0044@1|root,COG0044@2|Bacteria,1WMCK@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	F	Amidohydrolase family	-	-	3.5.2.2	ko:K01464	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R02269,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Amidohydro_1
k59_667792_1	4533.OB01G18320.1	6.16e-38	141.0	COG1052@1|root,KOG0069@2759|Eukaryota,37IZW@33090|Viridiplantae,3G9SJ@35493|Streptophyta,3KS89@4447|Liliopsida,3I8QH@38820|Poales	35493|Streptophyta	C	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	-	-	-	ko:K15919	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01388	RC00031	ko00000,ko00001,ko00002	-	-	-	2-Hacid_dh,2-Hacid_dh_C,NAD_binding_2
k59_834567_1	1385420.FRA_50c15300	1.41e-12	67.0	COG1873@1|root,COG1873@2|Bacteria,1QTWZ@1224|Proteobacteria,1SABC@1236|Gammaproteobacteria,4632Z@72273|Thiotrichales	72273|Thiotrichales	S	PRC-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	PRC
k59_1724070_1	102125.Xen7305DRAFT_00053330	7.9e-64	214.0	COG0028@1|root,COG2146@1|root,COG0028@2|Bacteria,COG2146@2|Bacteria,1G17K@1117|Cyanobacteria,3VHKJ@52604|Pleurocapsales	1117|Cyanobacteria	EH	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	-	-	-	-	-	-	-	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_778983_1	243090.RB10599	2.16e-25	108.0	COG3119@1|root,COG3119@2|Bacteria,2J1TM@203682|Planctomycetes	203682|Planctomycetes	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
k59_890207_2	1379270.AUXF01000006_gene67	3.07e-23	95.5	COG1610@1|root,COG1610@2|Bacteria,1ZTS3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Yqey-like protein	-	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
k59_1446165_1	1284708.HMPREF1634_08040	7.24e-08	58.2	COG2270@1|root,COG2270@2|Bacteria,1TRTH@1239|Firmicutes,24AYI@186801|Clostridia	186801|Clostridia	S	Major Facilitator	-	-	-	ko:K06902	ko04138,map04138	-	-	-	ko00000,ko00001,ko02000,ko04131	2.A.1.24,9.A.15.1	-	-	ATG22
k59_1056966_1	443152.MDG893_15050	9.96e-07	51.6	COG2423@1|root,COG2423@2|Bacteria,1N3EI@1224|Proteobacteria,1RR4Y@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Cyclodeaminase	ocd2	-	1.4.1.1,4.3.1.12	ko:K01750,ko:K19244	ko00250,ko00330,ko00430,ko01100,ko01110,ko01130,ko01230,map00250,map00330,map00430,map01100,map01110,map01130,map01230	-	R00396,R00671	RC00008,RC00354	ko00000,ko00001,ko01000	-	-	iJN746.PP_4431	OCD_Mu_crystall
k59_1056966_2	102232.GLO73106DRAFT_00020370	3.21e-67	210.0	COG0426@1|root,COG0426@2|Bacteria	2|Bacteria	C	nitric oxide reductase activity	-	-	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	Fer4,Lactamase_B
k59_1668509_1	111780.Sta7437_3987	3.79e-38	137.0	COG0412@1|root,COG0412@2|Bacteria,1G3JS@1117|Cyanobacteria,3VHRB@52604|Pleurocapsales	1117|Cyanobacteria	Q	Phospholipase/Carboxylesterase	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
k59_1629630_1	439235.Dalk_5087	6.61e-144	421.0	COG3385@1|root,COG3385@2|Bacteria,1PMXF@1224|Proteobacteria,43B8Z@68525|delta/epsilon subdivisions,2X6NB@28221|Deltaproteobacteria,2MPI8@213118|Desulfobacterales	1224|Proteobacteria	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4372
k59_1185589_1	553385.JEMF01000032_gene2586	1.49e-51	179.0	COG1174@1|root,COG1732@1|root,COG1174@2|Bacteria,COG1732@2|Bacteria,1MXA1@1224|Proteobacteria,1RQ1F@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	transport	yehZ	-	-	ko:K05845,ko:K05846	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1,OpuAC
k59_73615_1	536019.Mesop_2129	5.65e-160	460.0	COG0651@1|root,COG0651@2|Bacteria,1MVBA@1224|Proteobacteria,2TSRU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	CP	PFAM NADH Ubiquinone plastoquinone (complex I)	hyfF	-	-	ko:K12141	-	-	-	-	ko00000,ko01000	-	-	-	Proton_antipo_M
k59_1019515_2	357808.RoseRS_3975	5.36e-08	56.6	COG2348@1|root,COG2348@2|Bacteria,2G6KK@200795|Chloroflexi,375A7@32061|Chloroflexia	32061|Chloroflexia	V	PFAM Methicillin resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	FemAB
k59_908528_1	396588.Tgr7_1528	1.16e-26	111.0	COG1322@1|root,COG1322@2|Bacteria,1MWHV@1224|Proteobacteria,1RMB8@1236|Gammaproteobacteria,1WYRX@135613|Chromatiales	135613|Chromatiales	S	RmuC family	-	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
k59_351117_1	65393.PCC7424_3654	6.01e-63	217.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1G0XM@1117|Cyanobacteria,3KJ6U@43988|Cyanothece	1117|Cyanobacteria	C	glutamate synthase alpha subunit domain protein	gltB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.7.1	ko:K00284	ko00630,ko00910,ko01120,map00630,map00910,map01120	-	R00021,R10086	RC00006,RC00010	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_1187661_1	1123354.AUDR01000015_gene380	4.83e-45	166.0	COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,2VICG@28216|Betaproteobacteria,1KR9Y@119069|Hydrogenophilales	119069|Hydrogenophilales	J	Glycyl-tRNA synthetase beta subunit	-	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
k59_743201_2	318586.Pden_3846	1.16e-70	222.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2TU72@28211|Alphaproteobacteria,2PWHY@265|Paracoccus	28211|Alphaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve,rve_3
k59_1631603_1	67352.JODS01000010_gene4773	2.56e-63	211.0	COG4799@1|root,COG4799@2|Bacteria,2GIRU@201174|Actinobacteria	201174|Actinobacteria	I	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta	accD1	-	6.4.1.4	ko:K01969	ko00280,ko01100,map00280,map01100	M00036	R04138	RC00367,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_630988_1	1201288.M900_1977	7.2e-11	65.9	COG5184@1|root,COG5184@2|Bacteria,1R504@1224|Proteobacteria,42YUY@68525|delta/epsilon subdivisions,2WU6Z@28221|Deltaproteobacteria	28221|Deltaproteobacteria	DZ	Alpha-tubulin suppressor and related RCC1 domain-containing	-	-	-	-	-	-	-	-	-	-	-	-	DUF4215,RCC1_2
k59_75678_2	1234595.C725_1790	3.54e-11	64.3	COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,2TRWZ@28211|Alphaproteobacteria,4BS41@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_186681_1	357808.RoseRS_1640	1.35e-06	56.6	COG1572@1|root,COG1572@2|Bacteria,2G83M@200795|Chloroflexi,377MG@32061|Chloroflexia	32061|Chloroflexia	Q	CARDB	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,Chlam_PMP,DUF1573
k59_75690_1	1380391.JIAS01000018_gene838	3.31e-107	320.0	COG4671@1|root,COG4671@2|Bacteria,1N1PQ@1224|Proteobacteria,2TSTV@28211|Alphaproteobacteria,2JRG0@204441|Rhodospirillales	204441|Rhodospirillales	S	Glycosyltransferase family 28 C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tran_28_C
k59_1354676_1	479434.Sthe_3420	9.01e-27	110.0	COG1132@1|root,COG1132@2|Bacteria,2G5P7@200795|Chloroflexi,27XZA@189775|Thermomicrobia	189775|Thermomicrobia	V	ABC transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_1354676_2	525904.Tter_0837	1.21e-35	129.0	COG2120@1|root,COG2120@2|Bacteria,2NQ6H@2323|unclassified Bacteria	2|Bacteria	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
k59_1021635_1	1120949.KB903294_gene3478	1.46e-30	125.0	COG2203@1|root,COG4585@1|root,COG2203@2|Bacteria,COG4585@2|Bacteria,2GIXR@201174|Actinobacteria,4DHP1@85008|Micromonosporales	201174|Actinobacteria	T	CHASE3 domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,DUF4118,GAF,HAMP,HATPase_c,HisKA_3,PAS_4,PAS_9,Response_reg
k59_186701_1	1123511.KB905839_gene593	1.87e-12	74.7	COG1538@1|root,COG1538@2|Bacteria,1TQ0W@1239|Firmicutes,4H3MR@909932|Negativicutes	909932|Negativicutes	MU	outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_1021640_1	1200792.AKYF01000010_gene2278	1.54e-46	165.0	COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,4HA2G@91061|Bacilli,26R1I@186822|Paenibacillaceae	91061|Bacilli	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897,ko:K18661	ko00061,ko00071,ko00280,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map00280,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280,R03383	RC00004,RC00014,RC00137	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
k59_186702_1	1231185.BAMP01000034_gene512	9.19e-87	278.0	COG4631@1|root,COG4631@2|Bacteria,1NQSR@1224|Proteobacteria,2TTAB@28211|Alphaproteobacteria,43IBQ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	F	Aldehyde oxidase and xanthine dehydrogenase a b hammerhead	xdhB	-	1.17.1.4	ko:K13482	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_520761_1	96561.Dole_2335	1.75e-09	61.6	COG0745@1|root,COG0745@2|Bacteria,1NE8H@1224|Proteobacteria,42NEH@68525|delta/epsilon subdivisions,2WK1M@28221|Deltaproteobacteria,2MHU4@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Cytidylate_kin2,Response_reg
k59_910821_1	891968.Anamo_0367	1.1e-81	261.0	COG0018@1|root,COG0018@2|Bacteria,3TA5K@508458|Synergistetes	508458|Synergistetes	J	Arginyl-tRNA synthetase	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
k59_1021651_1	522772.Dacet_2980	5.38e-35	138.0	COG0747@1|root,COG0747@2|Bacteria,2GEIN@200930|Deferribacteres	200930|Deferribacteres	E	Peptide nickel ABC transporter, substrate-binding protein	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_1410275_1	913865.DOT_3820	9.91e-11	68.6	COG0768@1|root,COG0768@2|Bacteria,1TP93@1239|Firmicutes,248KB@186801|Clostridia,260BS@186807|Peptococcaceae	186801|Clostridia	M	TIGRFAM stage V sporulation protein D	spoVD	-	-	ko:K08384	ko00550,map00550	-	-	-	ko00000,ko00001,ko01011	-	-	-	PASTA,PBP_dimer,Transpeptidase
k59_575732_1	525904.Tter_1284	1.05e-29	120.0	COG0477@1|root,COG2814@2|Bacteria,2NQKR@2323|unclassified Bacteria	2|Bacteria	EGP	Transmembrane secretion effector	pimH	-	-	-	-	-	-	-	-	-	-	-	MFS_3
k59_1410289_1	1267535.KB906767_gene5174	1.02e-43	161.0	COG0348@1|root,COG3336@1|root,COG0348@2|Bacteria,COG3336@2|Bacteria,3Y3CM@57723|Acidobacteria	57723|Acidobacteria	C	PFAM Cytochrome c oxidase caa3-type, assembly factor CtaG-related	-	-	-	-	-	-	-	-	-	-	-	-	Caa3_CtaG
k59_743289_1	469371.Tbis_1865	3.44e-60	198.0	COG2224@1|root,COG2224@2|Bacteria,2GNAY@201174|Actinobacteria,4DZJ0@85010|Pseudonocardiales	201174|Actinobacteria	C	Isocitrate lyase	aceA	GO:0001101,GO:0001666,GO:0003674,GO:0003824,GO:0004451,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006081,GO:0006082,GO:0006097,GO:0006102,GO:0006950,GO:0008150,GO:0008152,GO:0009268,GO:0009405,GO:0009605,GO:0009607,GO:0009628,GO:0009987,GO:0010033,GO:0010034,GO:0010447,GO:0016020,GO:0016829,GO:0016830,GO:0016833,GO:0019752,GO:0019899,GO:0032787,GO:0033554,GO:0033993,GO:0035375,GO:0036293,GO:0036294,GO:0042221,GO:0043207,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046421,GO:0046487,GO:0046677,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0070482,GO:0070542,GO:0070887,GO:0071453,GO:0071456,GO:0071704,GO:0071944,GO:0072350,GO:0075136,GO:0075141,GO:1901700	4.1.3.1	ko:K01637	ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200	M00012	R00479	RC00311,RC00313	ko00000,ko00001,ko00002,ko01000	-	-	-	ICL
k59_743289_2	40571.JOEA01000017_gene576	6.21e-05	44.7	COG2225@1|root,COG2225@2|Bacteria,2GJGP@201174|Actinobacteria,4DY8N@85010|Pseudonocardiales	201174|Actinobacteria	C	Belongs to the malate synthase family	aceB	-	2.3.3.9	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472	RC00004,RC00308,RC02747	ko00000,ko00001,ko00002,ko01000	-	-	-	Malate_synthase
k59_242668_1	1049564.TevJSym_ab00170	9.3e-36	134.0	COG2270@1|root,COG2270@2|Bacteria,1MWXB@1224|Proteobacteria,1S03J@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Major facilitator superfamily	-	-	-	ko:K06902	ko04138,map04138	-	-	-	ko00000,ko00001,ko02000,ko04131	2.A.1.24,9.A.15.1	-	-	ATG22
k59_575754_1	1459636.NTE_02553	2.11e-22	90.9	COG0839@1|root,arCOG04654@2157|Archaea,41SM8@651137|Thaumarchaeota	651137|Thaumarchaeota	C	PFAM NADH-ubiquinone plastoquinone oxidoreductase chain 6	-	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
k59_575754_2	1459636.NTE_02554	3.79e-83	247.0	COG1143@1|root,arCOG01543@2157|Archaea,41SGW@651137|Thaumarchaeota	651137|Thaumarchaeota	C	4Fe-4S binding domain	-	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4,Fer4_4
k59_1521202_1	1267533.KB906734_gene3692	1.38e-51	181.0	COG2010@1|root,COG2010@2|Bacteria,3Y650@57723|Acidobacteria,2JKDC@204432|Acidobacteriia	204432|Acidobacteriia	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Cytochrome_CBB3,Paired_CXXCH_1
k59_688110_2	488538.SAR116_2097	5.37e-68	215.0	COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,2TRT1@28211|Alphaproteobacteria,4BT7W@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K02049,ko:K15555	ko00920,ko02010,map00920,map02010	M00188,M00436	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.16,3.A.1.17,3.A.1.17.2	-	-	ABC_tran
k59_688112_1	1384054.N790_01905	9.46e-15	71.6	COG0454@1|root,COG0454@2|Bacteria,1RDBA@1224|Proteobacteria,1S225@1236|Gammaproteobacteria,1X626@135614|Xanthomonadales	135614|Xanthomonadales	K	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_20518_1	1038859.AXAU01000014_gene1413	2.76e-27	109.0	COG4638@1|root,COG4638@2|Bacteria,1N6MJ@1224|Proteobacteria,2TVEE@28211|Alphaproteobacteria,3JWXQ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Ring hydroxylating alpha subunit (catalytic domain)	-	-	-	ko:K00479	-	-	-	-	ko00000	-	-	-	Rieske,Ring_hydroxyl_A
k59_20518_2	928724.SacglDRAFT_00776	8.87e-05	45.1	COG1414@1|root,COG1414@2|Bacteria,2GMEA@201174|Actinobacteria,4E5K1@85010|Pseudonocardiales	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
k59_130957_1	933262.AXAM01000222_gene924	2.28e-44	154.0	COG1989@1|root,COG1989@2|Bacteria,1MUZF@1224|Proteobacteria,42S2A@68525|delta/epsilon subdivisions,2WMQ8@28221|Deltaproteobacteria,2MJAD@213118|Desulfobacterales	28221|Deltaproteobacteria	NOU	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue	pilD	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
k59_186792_2	384765.SIAM614_03780	6.9e-38	139.0	COG0823@1|root,COG0823@2|Bacteria,1R5P1@1224|Proteobacteria,2U0ZV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	U	Periplasmic component of the Tol biopolymer transport system	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,Amidohydro_3,PD40
k59_1688273_1	234267.Acid_1779	2.18e-56	189.0	COG1304@1|root,COG1304@2|Bacteria	2|Bacteria	C	FMN binding	-	-	1.1.3.15,1.1.3.46	ko:K00104,ko:K16422	ko00261,ko00630,ko01055,ko01100,ko01110,ko01120,ko01130,map00261,map00630,map01055,map01100,map01110,map01120,map01130	-	R00475,R06633	RC00042,RC00240	ko00000,ko00001,ko01000	-	-	-	FMN_dh
k59_1631739_1	1122135.KB893146_gene1498	1.67e-46	164.0	COG0477@1|root,2Z82B@2|Bacteria,1R9GD@1224|Proteobacteria,2TTIS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EGP	COG0477 Permeases of the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_688132_1	1042376.AFPK01000029_gene1585	1.07e-24	102.0	COG1472@1|root,COG1472@2|Bacteria,4NE90@976|Bacteroidetes,1HX27@117743|Flavobacteriia,4062D@61432|unclassified Flavobacteriaceae	976|Bacteroidetes	G	Fibronectin type III-like domain	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
k59_688132_2	1122225.AULQ01000006_gene1035	8.73e-42	144.0	COG2273@1|root,COG2273@2|Bacteria,4NHP5@976|Bacteroidetes,1HZEJ@117743|Flavobacteriia	976|Bacteroidetes	G	Glycoside hydrolase family 16	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_16
k59_1187815_2	929556.Solca_3099	2.61e-107	313.0	COG0377@1|root,COG0377@2|Bacteria,4NZUK@976|Bacteroidetes,1IV9I@117747|Sphingobacteriia	976|Bacteroidetes	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
k59_1521238_1	323850.Shew_3808	4.33e-13	72.8	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,1RMSR@1236|Gammaproteobacteria,2Q961@267890|Shewanellaceae	1236|Gammaproteobacteria	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_S41
k59_1354817_1	1121930.AQXG01000002_gene2288	4.87e-49	167.0	COG0738@1|root,COG0738@2|Bacteria,4NEB2@976|Bacteroidetes,1IX2C@117747|Sphingobacteriia	976|Bacteroidetes	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_20553_1	511062.GU3_01905	1.19e-82	262.0	COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,1RMP2@1236|Gammaproteobacteria,1Y3Y3@135624|Aeromonadales	135624|Aeromonadales	E	Belongs to the IlvD Edd family	-	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
k59_186818_1	395019.Bmul_3607	6.32e-16	82.4	COG0523@1|root,COG0523@2|Bacteria,1MVZV@1224|Proteobacteria,2VQGK@28216|Betaproteobacteria,1K2U9@119060|Burkholderiaceae	28216|Betaproteobacteria	S	cobalamin synthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	CobW_C,cobW
k59_798917_1	1306174.JODP01000002_gene5711	6.55e-14	75.1	COG2154@1|root,COG2154@2|Bacteria,2I35Z@201174|Actinobacteria	201174|Actinobacteria	H	TIR domain	-	-	-	-	-	-	-	-	-	-	-	-	TIR_2
k59_631137_1	448385.sce1012	4.42e-40	144.0	COG2021@1|root,COG2021@2|Bacteria,1PG00@1224|Proteobacteria,439DK@68525|delta/epsilon subdivisions,2X4NG@28221|Deltaproteobacteria,2YZAN@29|Myxococcales	28221|Deltaproteobacteria	E	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
k59_1299044_1	1379270.AUXF01000005_gene656	2.55e-96	299.0	COG0465@1|root,COG0465@2|Bacteria,1ZSRI@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,Peptidase_M41
k59_1132928_1	1121335.Clst_2197	3.67e-101	296.0	COG4720@1|root,COG4720@2|Bacteria,1V1GT@1239|Firmicutes,24GT3@186801|Clostridia,3WPFI@541000|Ruminococcaceae	186801|Clostridia	S	Pfam:DUF3816	-	-	-	ko:K16924	-	M00582	-	-	ko00000,ko00002,ko02000	3.A.1.29	-	-	ECF-ribofla_trS
k59_20574_1	314345.SPV1_03943	3.92e-75	234.0	COG0437@1|root,COG0437@2|Bacteria	2|Bacteria	C	4 iron, 4 sulfur cluster binding	actB	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_7,Molybdop_Fe4S4,Molydop_binding
k59_575843_1	880073.Calab_2739	1.99e-32	118.0	COG2606@1|root,COG2606@2|Bacteria,2NPZ1@2323|unclassified Bacteria	2|Bacteria	S	Aminoacyl-tRNA editing domain	-	-	-	ko:K19055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
k59_743390_1	1192034.CAP_2385	1.75e-30	124.0	COG0659@1|root,COG0664@1|root,COG0659@2|Bacteria,COG0664@2|Bacteria,1MVWV@1224|Proteobacteria	1224|Proteobacteria	P	COG0659 Sulfate permease and related transporters (MFS superfamily	bicA	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp,cNMP_binding
k59_20588_1	42256.RradSPS_0358	2.62e-29	121.0	COG2909@1|root,COG2909@2|Bacteria,2HENR@201174|Actinobacteria,4CPC9@84995|Rubrobacteria	84995|Rubrobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	ko:K03556	-	-	-	-	ko00000,ko03000	-	-	-	AAA_16,AAA_22,GerE
k59_1631802_1	1229780.BN381_160026	6.17e-94	288.0	COG0649@1|root,COG0649@2|Bacteria,2GKEZ@201174|Actinobacteria,3UWKD@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	Belongs to the complex I 49 kDa subunit family	-	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
k59_1631802_2	1463926.JOCA01000010_gene2076	3.61e-12	67.0	COG0852@1|root,COG0852@2|Bacteria,2GNVP@201174|Actinobacteria	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	nuoC2	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
k59_298481_1	1126627.BAWE01000005_gene4806	1.22e-38	147.0	COG3206@1|root,COG3206@2|Bacteria,1RK0N@1224|Proteobacteria,2TSFQ@28211|Alphaproteobacteria,3JS8J@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Chain length determinant protein	-	-	-	-	-	-	-	-	-	-	-	-	GNVR,Wzz
k59_1076626_1	153721.MYP_3690	1.27e-58	203.0	COG0380@1|root,COG1877@1|root,COG0380@2|Bacteria,COG1877@2|Bacteria,4NGJ4@976|Bacteroidetes,47KIQ@768503|Cytophagia	976|Bacteroidetes	G	Trehalose-phosphatase	otsB	-	2.4.1.15,3.1.3.12	ko:K16055	ko00500,ko01100,map00500,map01100	-	R02737,R02778	RC00005,RC00017,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT20	-	Glyco_transf_20,Trehalose_PPase
k59_520937_1	1121930.AQXG01000002_gene2137	1.03e-10	68.6	COG4632@1|root,COG4632@2|Bacteria,4NR1M@976|Bacteroidetes	976|Bacteroidetes	G	COG4632 Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,NAGPA,fn3
k59_1187889_1	240015.ACP_3523	1.84e-81	259.0	COG1574@1|root,COG1574@2|Bacteria,3Y2UF@57723|Acidobacteria,2JIRH@204432|Acidobacteriia	204432|Acidobacteriia	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_1410435_1	326427.Cagg_0759	1.46e-78	243.0	COG0714@1|root,COG0714@2|Bacteria,2G5WI@200795|Chloroflexi,374WI@32061|Chloroflexia	32061|Chloroflexia	S	PFAM ATPase associated with various cellular activities, AAA_5	-	-	-	-	-	-	-	-	-	-	-	-	AAA_5
k59_1076633_2	563192.HMPREF0179_02340	9.01e-35	134.0	COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,42M28@68525|delta/epsilon subdivisions,2WJPF@28221|Deltaproteobacteria,2MA1S@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
k59_298488_1	929556.Solca_0050	9.31e-17	84.7	COG1470@1|root,COG3209@1|root,COG4932@1|root,COG1470@2|Bacteria,COG3209@2|Bacteria,COG4932@2|Bacteria,4PKBQ@976|Bacteroidetes,1J0N1@117747|Sphingobacteriia	976|Bacteroidetes	M	conserved repeat domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,Calx-beta,DUF11,SprB
k59_1187894_1	1195236.CTER_0541	1.66e-88	281.0	COG3808@1|root,COG3808@2|Bacteria,1TNZI@1239|Firmicutes,248KS@186801|Clostridia,3WHVU@541000|Ruminococcaceae	186801|Clostridia	C	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
k59_1521319_1	1121106.JQKB01000216_gene5175	7.18e-120	355.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TSGZ@28211|Alphaproteobacteria,2JQI5@204441|Rhodospirillales	204441|Rhodospirillales	L	Transposase IS116/IS110/IS902 family	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1187896_1	379066.GAU_0518	1.71e-188	552.0	COG0495@1|root,COG0495@2|Bacteria,1ZSXC@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Leucyl-tRNA synthetase, Domain 2	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
k59_1076646_1	512565.AMIS_8480	7.26e-10	58.9	COG0365@1|root,COG0365@2|Bacteria,2GM20@201174|Actinobacteria,4D8NB@85008|Micromonosporales	201174|Actinobacteria	I	Acetyl-coenzyme A synthetase N-terminus	-	-	6.2.1.16	ko:K01907	ko00280,ko00650,map00280,map00650	-	R01357	RC00004,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_1299121_1	1286632.P278_14720	1.98e-17	87.0	COG0457@1|root,COG2207@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2207@2|Bacteria,COG5616@2|Bacteria,4NFW7@976|Bacteroidetes,1HZQR@117743|Flavobacteriia	976|Bacteroidetes	K	COGs COG5616 integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	ANAPC3,Guanylate_cyc,HTH_18,TPR_8
k59_520962_1	1278309.KB907101_gene403	1.51e-16	80.5	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1XNAT@135619|Oceanospirillales	135619|Oceanospirillales	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF,GGDEF
k59_1577070_1	1316927.ATKI01000034_gene4683	2.02e-21	98.2	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1YT39@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF,PAS,PAS_3,PAS_4,PAS_9,Response_reg
k59_409714_1	1123355.JHYO01000014_gene1012	3.93e-53	188.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,36X41@31993|Methylocystaceae	28211|Alphaproteobacteria	V	AcrB/AcrD/AcrF family	-	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_853442_1	189753.AXAS01000084_gene6047	2.21e-31	127.0	COG1216@1|root,COG1216@2|Bacteria,1RAKR@1224|Proteobacteria,2U4HT@28211|Alphaproteobacteria,3K3B2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Glycosyltransferase family 87	-	-	-	-	-	-	-	-	-	-	-	-	GT87
k59_1354948_1	671143.DAMO_1019	1.55e-14	74.3	COG1488@1|root,COG1488@2|Bacteria,2NNUE@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	pncB	GO:0001666,GO:0003674,GO:0003824,GO:0004516,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009605,GO:0009607,GO:0009628,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016763,GO:0016874,GO:0016879,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0034355,GO:0034641,GO:0034654,GO:0036293,GO:0043094,GO:0043173,GO:0043207,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044403,GO:0044419,GO:0044464,GO:0046483,GO:0046496,GO:0047280,GO:0050896,GO:0051186,GO:0051188,GO:0051701,GO:0051704,GO:0051707,GO:0055086,GO:0070482,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0075136,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	iYO844.BSU31750	NAPRTase
k59_1354948_2	1439940.BAY1663_01731	5.44e-40	138.0	COG1335@1|root,COG1335@2|Bacteria,1MUGW@1224|Proteobacteria,1RZBF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	Nicotinamidase	pncA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006766,GO:0006767,GO:0006769,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008936,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009820,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0017144,GO:0018130,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0043094,GO:0043173,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	3.5.1.19	ko:K08281	ko00760,ko01100,map00760,map01100	-	R01268	RC00100	ko00000,ko00001,ko01000	-	-	iE2348C_1286.E2348C_1895,iECs_1301.ECs2475,iZ_1308.Z2802	Isochorismatase
k59_1151800_1	335659.S23_04500	8.79e-10	61.2	COG4566@1|root,COG4566@2|Bacteria,1PP24@1224|Proteobacteria,2TQN8@28211|Alphaproteobacteria,3JU3A@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	helix_turn_helix, Lux Regulon	MA20_39170	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_1151800_2	445970.ALIPUT_01903	3.49e-26	107.0	COG3404@1|root,COG3643@1|root,COG3404@2|Bacteria,COG3643@2|Bacteria,4NFE3@976|Bacteroidetes,2FMWT@200643|Bacteroidia,22U9H@171550|Rikenellaceae	976|Bacteroidetes	E	Formiminotransferase domain, N-terminal subdomain	ftcD	-	2.1.2.5,4.3.1.4	ko:K00603,ko:K13990	ko00340,ko00670,ko01100,map00340,map00670,map01100	-	R02287,R02302,R03189	RC00165,RC00221,RC00223,RC00688,RC00870	ko00000,ko00001,ko01000,ko03036,ko04147	-	-	-	FTCD,FTCD_C,FTCD_N
k59_149324_1	926569.ANT_10660	1.03e-97	306.0	COG0495@1|root,COG0495@2|Bacteria,2G5MX@200795|Chloroflexi	200795|Chloroflexi	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
k59_1042147_2	441768.ACL_0109	6.4e-25	103.0	COG0024@1|root,COG0024@2|Bacteria,3WT36@544448|Tenericutes	544448|Tenericutes	E	Methionine aminopeptidase	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
k59_485890_1	1303518.CCALI_01900	5.19e-88	268.0	COG1192@1|root,COG1192@2|Bacteria	2|Bacteria	D	plasmid maintenance	parA	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
k59_204343_1	748658.KB907314_gene125	1.48e-30	119.0	COG1226@1|root,2Z7ZD@2|Bacteria,1MXKM@1224|Proteobacteria,1RNMT@1236|Gammaproteobacteria,1WXIM@135613|Chromatiales	135613|Chromatiales	P	PFAM Ion transport	-	-	-	ko:K08714	-	-	-	-	ko00000,ko02000	1.A.1.14	-	-	Ion_trans
k59_1596341_1	591158.SSMG_02040	2.31e-41	146.0	COG2030@1|root,COG2030@2|Bacteria,2GJJI@201174|Actinobacteria	201174|Actinobacteria	I	dehydratase	hsd4B	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydrat_N,MaoC_dehydratas
k59_1095864_1	215803.DB30_5558	1.23e-31	127.0	COG3501@1|root,COG3501@2|Bacteria,1MU7Q@1224|Proteobacteria,42Q4M@68525|delta/epsilon subdivisions,2WKZN@28221|Deltaproteobacteria,2YZHX@29|Myxococcales	28221|Deltaproteobacteria	S	Phage late control gene D protein (GPD)	tssI	-	-	ko:K11904	ko03070,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	Gp5_C,Phage_GPD
k59_1206391_1	111781.Lepto7376_3673	9.29e-85	260.0	COG3039@1|root,COG3039@2|Bacteria,1G1EK@1117|Cyanobacteria,1HEKZ@1150|Oscillatoriales	1117|Cyanobacteria	L	SPTR Transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_3
k59_1428882_1	4577.GRMZM2G026117_P02	2.51e-13	71.2	COG0181@1|root,KOG2892@2759|Eukaryota,37MFR@33090|Viridiplantae,3GE8X@35493|Streptophyta,3KU3Q@4447|Liliopsida,3IEUF@38820|Poales	35493|Streptophyta	H	Porphobilinogen deaminase, dipyromethane cofactor binding domain	HEMC	GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0006950,GO:0006952,GO:0008150,GO:0008152,GO:0009058,GO:0009451,GO:0009507,GO:0009526,GO:0009532,GO:0009536,GO:0009570,GO:0009605,GO:0009607,GO:0009617,GO:0009941,GO:0009987,GO:0015994,GO:0015995,GO:0016070,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0031967,GO:0031975,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0042742,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046148,GO:0046483,GO:0048046,GO:0050896,GO:0051186,GO:0051188,GO:0051704,GO:0051707,GO:0071704,GO:0090304,GO:0098542,GO:1900865,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
k59_1428882_2	1040989.AWZU01000033_gene3553	1.75e-14	72.4	COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,2TSF7@28211|Alphaproteobacteria,3JRK2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360,GO:1901564	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
k59_1374103_1	1123073.KB899241_gene2266	1.59e-07	53.9	COG1565@1|root,COG1565@2|Bacteria,1N3CJ@1224|Proteobacteria,1RYCJ@1236|Gammaproteobacteria,1X3YI@135614|Xanthomonadales	135614|Xanthomonadales	S	Putative S-adenosyl-L-methionine-dependent methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_28
k59_1374103_2	1121374.KB891575_gene1013	1.33e-25	103.0	COG1028@1|root,COG1028@2|Bacteria,1MUUV@1224|Proteobacteria,1RMJU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	ycdF	-	1.5.1.33	ko:K03793	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
k59_648733_1	1121403.AUCV01000073_gene1309	0.000469	48.1	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
k59_38274_1	861299.J421_3288	5.87e-57	192.0	COG1005@1|root,COG1005@2|Bacteria,1ZTDY@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	-	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
k59_1596387_2	1501230.ET33_24190	0.000313	46.6	COG2010@1|root,COG2010@2|Bacteria,1VEEP@1239|Firmicutes,4HP6N@91061|Bacilli,26YFW@186822|Paenibacillaceae	91061|Bacilli	C	Cytochrome C oxidase, cbb3-type, subunit III	cccB	-	-	ko:K12263,ko:K13300	-	-	-	-	ko00000	-	-	-	Cytochrome_CBB3
k59_1374129_1	1192034.CAP_5994	4.25e-62	193.0	COG3832@1|root,COG3832@2|Bacteria,1RA7N@1224|Proteobacteria	1224|Proteobacteria	NT	Activator of Hsp90 ATPase	MA20_01005	-	-	-	-	-	-	-	-	-	-	-	AHSA1
k59_1374129_2	402626.Rpic_0076	1.88e-21	86.7	2E54V@1|root,32ZXS@2|Bacteria,1N6QG@1224|Proteobacteria,2VWQZ@28216|Betaproteobacteria,1KAMT@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_539364_1	585530.HMPREF0183_0343	4.42e-59	207.0	COG0508@1|root,COG0567@1|root,COG0508@2|Bacteria,COG0567@2|Bacteria,2GIU6@201174|Actinobacteria,4F8UV@85019|Brevibacteriaceae	201174|Actinobacteria	C	2-oxoglutarate dehydrogenase C-terminal	kgd	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006103,GO:0008150,GO:0008152,GO:0008683,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016740,GO:0016744,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0030312,GO:0032991,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0045333,GO:0046872,GO:0050439,GO:0051186,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:1902494,GO:1990204,GO:1990234	1.2.4.2,4.1.1.71	ko:K00164,ko:K01616	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1248c	2-oxoacid_dh,2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
k59_149401_1	765869.BDW_11695	1.74e-71	232.0	COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,42MHK@68525|delta/epsilon subdivisions,2MSTJ@213481|Bdellovibrionales,2WJAZ@28221|Deltaproteobacteria	213481|Bdellovibrionales	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
k59_1760834_1	941824.TCEL_02201	4.75e-08	51.2	COG0663@1|root,COG0663@2|Bacteria	2|Bacteria	G	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily	yrdA	-	-	-	-	-	-	-	-	-	-	-	Hexapep,Hexapep_2
k59_1760834_2	649831.L083_0138	7.55e-52	181.0	COG0034@1|root,COG0034@2|Bacteria,2GK6I@201174|Actinobacteria,4DB2D@85008|Micromonosporales	201174|Actinobacteria	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	GO:0008150,GO:0040007	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
k59_648769_1	991.IW20_02720	9.68e-15	82.0	COG3579@1|root,COG3579@2|Bacteria,4NE02@976|Bacteroidetes,1HXT9@117743|Flavobacteriia,2NTRT@237|Flavobacterium	976|Bacteroidetes	E	aminopeptidase	pepC	-	3.4.22.40	ko:K01372	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_C1,Peptidase_C1_2
k59_872398_1	667014.Thein_0706	5.57e-40	147.0	COG5653@1|root,COG5653@2|Bacteria,2GICA@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	M	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_6
k59_1649490_1	1247963.JPHU01000002_gene2674	3.67e-32	129.0	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,2TQMY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc
k59_1264653_1	485913.Krac_5203	7.97e-37	134.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1,Methyltransf_11,Methyltransf_23,Methyltransf_25
k59_648802_1	1192034.CAP_8968	6.18e-20	97.1	COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,42MN5@68525|delta/epsilon subdivisions,2WINN@28221|Deltaproteobacteria,2YU3A@29|Myxococcales	28221|Deltaproteobacteria	H	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	-	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,DUF294,GlnD_UR_UTase,GlnE,HD,NTP_transf_2
k59_707558_1	670487.Ocepr_1706	2.91e-43	153.0	COG0601@1|root,COG0601@2|Bacteria,1WIUD@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	EP	ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_594509_1	1122138.AQUZ01000010_gene5101	2.23e-81	272.0	COG1201@1|root,COG1201@2|Bacteria,2GJG3@201174|Actinobacteria,4DPDX@85009|Propionibacteriales	201174|Actinobacteria	L	DEAD/H associated	lhr	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,HTH_42,Helicase_C
k59_1151954_1	1121918.ARWE01000001_gene339	3.63e-16	84.7	COG2113@1|root,COG2113@2|Bacteria,1MWZU@1224|Proteobacteria,42PKK@68525|delta/epsilon subdivisions,2WM3E@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	of ABC-type glycine betaine transport system	-	-	-	ko:K02002	ko02010,map02010	M00208	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	OpuAC
k59_985976_1	927677.ALVU02000001_gene2961	4.37e-57	186.0	COG0116@1|root,COG0116@2|Bacteria,1GQF9@1117|Cyanobacteria	1117|Cyanobacteria	L	Histone methylation protein DOT1	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
k59_318466_1	749414.SBI_01426	1.4e-28	115.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria	201174|Actinobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.39	ko:K00146	ko00360,ko00643,ko01100,ko01120,map00360,map00643,map01100,map01120	-	R02536	RC00080	ko00000,ko00001,ko01000	-	-	-	Aldedh
k59_817420_1	857087.Metme_4114	5.96e-12	67.8	COG1587@1|root,COG1587@2|Bacteria,1MWZD@1224|Proteobacteria,1RM9K@1236|Gammaproteobacteria,1XEZI@135618|Methylococcales	135618|Methylococcales	H	Uroporphyrinogen-III synthase HemD	-	-	4.2.1.75	ko:K01719	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165	RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4
k59_872463_1	1041142.ATTP01000015_gene6730	6.4e-54	191.0	COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,2TQPK@28211|Alphaproteobacteria,4BDQB@82115|Rhizobiaceae	28211|Alphaproteobacteria	J	Anticodon-binding domain of tRNA	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
k59_1151975_1	1313172.YM304_42600	2.56e-62	207.0	COG0305@1|root,COG0305@2|Bacteria,2GKXQ@201174|Actinobacteria,4CMT1@84992|Acidimicrobiia	84992|Acidimicrobiia	L	Participates in initiation and elongation during chromosome replication	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
k59_1096016_1	313612.L8106_21312	3.21e-59	210.0	COG3899@1|root,COG5001@1|root,COG3899@2|Bacteria,COG5001@2|Bacteria,1GBKM@1117|Cyanobacteria,1H7D9@1150|Oscillatoriales	1117|Cyanobacteria	KLT	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GAF,GAF_2,GGDEF,Guanylate_cyc,HATPase_c,HisKA,PAS_3,PAS_4,Pkinase,Response_reg
k59_1539405_1	716928.AJQT01000079_gene991	2.24e-42	159.0	COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TW3C@28211|Alphaproteobacteria,4BI55@82115|Rhizobiaceae	28211|Alphaproteobacteria	IQ	Phosphopantetheine attachment site	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C_2,Acyltransferase,PP-binding
k59_761630_1	1112274.KI911560_gene152	7.44e-22	95.5	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,2VI4A@28216|Betaproteobacteria,2KKQ5@206350|Nitrosomonadales	206350|Nitrosomonadales	EF	PFAM Carbamoyl-phosphate synthase L chain	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_761630_2	398578.Daci_4930	3.19e-41	140.0	COG0782@1|root,COG0782@2|Bacteria,1RCXW@1224|Proteobacteria,2VQ16@28216|Betaproteobacteria,4ADKA@80864|Comamonadaceae	28216|Betaproteobacteria	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
k59_1429031_1	1150474.JQJI01000022_gene653	1.17e-11	65.9	COG0469@1|root,COG0469@2|Bacteria,2GBY7@200918|Thermotogae	200918|Thermotogae	G	Belongs to the pyruvate kinase family	-	GO:0003674,GO:0003824,GO:0004743,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
k59_1429031_2	1124982.MSI_07660	2.07e-30	116.0	COG1235@1|root,COG1235@2|Bacteria,2J7C5@203691|Spirochaetes	203691|Spirochaetes	S	COGs COG1235 Metal-dependent hydrolase of the beta-lactamase superfamily I	phnP	-	3.1.4.55	ko:K06167	ko00440,map00440	-	R10205	RC00296	ko00000,ko00001,ko01000	-	-	-	Lactamase_B_2
k59_1596516_1	379066.GAU_1135	6.59e-82	252.0	COG2120@1|root,COG2120@2|Bacteria,1ZTDK@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	GlcNAc-PI de-N-acetylase	-	-	-	ko:K01463	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
k59_1596516_2	926550.CLDAP_19400	8.18e-07	50.4	COG0577@1|root,COG0577@2|Bacteria,2G65B@200795|Chloroflexi	200795|Chloroflexi	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_986002_1	338963.Pcar_3001	2.15e-60	209.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MQ0@68525|delta/epsilon subdivisions,2WJ2A@28221|Deltaproteobacteria,43SE5@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_38399_1	1123258.AQXZ01000013_gene1945	2.33e-13	73.2	COG2207@1|root,COG2207@2|Bacteria,2GWDZ@201174|Actinobacteria,4FUA3@85025|Nocardiaceae	201174|Actinobacteria	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
k59_260490_1	1547437.LL06_00355	1.82e-10	61.6	COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,2TUVG@28211|Alphaproteobacteria,43NST@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	Zinc-binding dehydrogenase	-	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_260490_2	1205680.CAKO01000040_gene792	3.02e-56	179.0	COG2050@1|root,COG2050@2|Bacteria,1RDVV@1224|Proteobacteria,2UANF@28211|Alphaproteobacteria,2JX1W@204441|Rhodospirillales	204441|Rhodospirillales	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
k59_1096048_2	344747.PM8797T_07307	1.4e-37	136.0	COG0668@1|root,COG0668@2|Bacteria,2IZYX@203682|Planctomycetes	203682|Planctomycetes	M	COG0668 Small-conductance mechanosensitive channel	-	-	-	ko:K03442	-	-	-	-	ko00000,ko02000	1.A.23.2	-	-	MS_channel,TM_helix
k59_1319510_1	1110502.TMO_1372	5.02e-90	275.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TQKE@28211|Alphaproteobacteria,2JPPM@204441|Rhodospirillales	204441|Rhodospirillales	I	COG1960 Acyl-CoA dehydrogenases	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_1649582_1	105422.BBPM01000060_gene4257	2.02e-101	302.0	COG1071@1|root,COG1071@2|Bacteria,2GK3W@201174|Actinobacteria,2NNCT@228398|Streptacidiphilus	201174|Actinobacteria	C	Dehydrogenase E1 component	acoA	-	1.2.4.1	ko:K00161,ko:K21416	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
k59_594585_1	234267.Acid_1599	2.56e-55	193.0	COG0793@1|root,COG0793@2|Bacteria,3Y6R0@57723|Acidobacteria	57723|Acidobacteria	M	Peptidase family S41	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S41
k59_372667_1	518766.Rmar_1111	2.01e-86	276.0	COG1331@1|root,COG1331@2|Bacteria,4NFE2@976|Bacteroidetes,1FIJF@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
k59_149561_2	56780.SYN_00801	3.24e-43	148.0	COG2945@1|root,COG2945@2|Bacteria	2|Bacteria	-	-	-	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009111,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0017144,GO:0034641,GO:0042365,GO:0042737,GO:0042802,GO:0042803,GO:0042816,GO:0042820,GO:0044237,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046483,GO:0046700,GO:0046983,GO:0047411,GO:0071704,GO:0072524,GO:0072526,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575	3.5.1.29	ko:K07020,ko:K18614	ko00750,ko01120,map00750,map01120	-	R01649	RC00300,RC00575	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_5,Abhydrolase_6,LIP,UPF0227
k59_149561_3	266265.Bxe_C0775	1.63e-07	52.8	COG0665@1|root,COG0665@2|Bacteria,1MVGP@1224|Proteobacteria,2VIFN@28216|Betaproteobacteria,1JZZN@119060|Burkholderiaceae	28216|Betaproteobacteria	E	fad dependent oxidoreductase	ordL	-	-	-	-	-	-	-	-	-	-	-	DAO
k59_1429084_1	1198114.AciX9_0340	9.64e-10	60.1	COG1181@1|root,COG1181@2|Bacteria,3Y3HW@57723|Acidobacteria,2JI4N@204432|Acidobacteriia	204432|Acidobacteriia	M	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
k59_1651570_1	518766.Rmar_1080	7.07e-102	320.0	COG1472@1|root,COG1472@2|Bacteria,4NE90@976|Bacteroidetes,1FIS9@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	G	PFAM glycoside hydrolase family 3 domain protein	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C,NAGLU,NAGLU_C,NAGLU_N
k59_1321755_1	204536.SULAZ_0160	1.03e-45	159.0	COG1186@1|root,COG1186@2|Bacteria,2G3P3@200783|Aquificae	200783|Aquificae	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
k59_1598775_1	243231.GSU2308	2.39e-11	64.3	COG0281@1|root,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,42MDI@68525|delta/epsilon subdivisions,2WIVY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	malic protein domain protein	-	-	1.1.1.38,1.1.1.40	ko:K00027,ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,ko02020,map00620,map00710,map01100,map01120,map01200,map02020	M00169,M00172	R00214,R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,malic
k59_391143_2	1300345.LF41_2244	2.98e-36	134.0	COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,1RN2A@1236|Gammaproteobacteria,1X7MH@135614|Xanthomonadales	135614|Xanthomonadales	E	Glycine cleavage T-protein C-terminal barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	GCV_T,GCV_T_C
k59_1614123_1	485916.Dtox_3162	7.5e-28	116.0	COG0572@1|root,COG0572@2|Bacteria,1TQ4V@1239|Firmicutes,249IT@186801|Clostridia,26138@186807|Peptococcaceae	186801|Clostridia	F	PFAM Phosphoribulokinase uridine kinase	udk	-	2.7.1.48	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PRK
k59_1558614_1	1209989.TepiRe1_1096	4.51e-20	93.6	COG0614@1|root,COG0614@2|Bacteria,1UNE3@1239|Firmicutes,24AKE@186801|Clostridia,42FIR@68295|Thermoanaerobacterales	186801|Clostridia	P	PFAM periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
k59_1558621_1	296591.Bpro_2830	6.88e-23	96.3	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2VH7B@28216|Betaproteobacteria,4AC80@80864|Comamonadaceae	1224|Proteobacteria	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysK	-	2.5.1.47,4.2.1.22	ko:K01697,ko:K01738	ko00260,ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021,M00035,M00338	R00891,R00897,R01290,R03601,R04859,R04942	RC00020,RC00056,RC00069,RC00256,RC00489,RC01246,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	CBS,PALP
k59_1558621_2	391625.PPSIR1_05778	0.000781	42.7	COG2114@1|root,COG2114@2|Bacteria,1MV1V@1224|Proteobacteria,42N5S@68525|delta/epsilon subdivisions,2WIUS@28221|Deltaproteobacteria,2YYZ3@29|Myxococcales	28221|Deltaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
k59_2084_1	756272.Plabr_3349	2.63e-55	196.0	COG0841@1|root,COG0841@2|Bacteria,2IY6W@203682|Planctomycetes	203682|Planctomycetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_113161_1	1521187.JPIM01000011_gene2638	3.04e-20	83.6	COG1652@1|root,COG1652@2|Bacteria	2|Bacteria	S	positive regulation of growth rate	ygaU	GO:0003674,GO:0005488,GO:0008150,GO:0010035,GO:0010038,GO:0030955,GO:0031420,GO:0035864,GO:0042221,GO:0043167,GO:0043169,GO:0046872,GO:0050896	-	-	-	-	-	-	-	-	-	-	BON,LysM
k59_113161_2	32057.KB217483_gene9333	5.07e-33	126.0	COG3500@1|root,COG3500@2|Bacteria,1GBYP@1117|Cyanobacteria,1HQZI@1161|Nostocales	1117|Cyanobacteria	S	Late control gene D protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1669842_1	643867.Ftrac_3270	9.12e-38	145.0	COG1505@1|root,COG1505@2|Bacteria,4NFJS@976|Bacteroidetes,47JBG@768503|Cytophagia	976|Bacteroidetes	E	PFAM Prolyl oligopeptidase, N-terminal beta-propeller domain	pep	GO:0005575,GO:0005623,GO:0042597,GO:0044464	3.4.21.26	ko:K01322	ko04614,map04614	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
k59_669186_1	997296.PB1_01235	1.32e-54	186.0	COG0541@1|root,COG0541@2|Bacteria,1TP06@1239|Firmicutes,4H9T4@91061|Bacilli,1ZB4I@1386|Bacillus	91061|Bacilli	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
k59_669186_2	1302858.I871_03630	0.00061	39.7	COG0228@1|root,COG0228@2|Bacteria,2J8AD@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	-	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
k59_224344_1	861299.J421_0886	1.99e-30	113.0	COG1595@1|root,COG1595@2|Bacteria,1ZUWT@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
k59_502345_1	391616.OA238_c35150	1.33e-77	241.0	COG4977@1|root,COG4977@2|Bacteria,1MUDK@1224|Proteobacteria,2U1C5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI,HTH_18
k59_1447566_2	247633.GP2143_17796	1.99e-05	52.4	28NHI@1|root,2ZBJA@2|Bacteria,1RCPZ@1224|Proteobacteria,1ST6N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1114031_1	1089552.KI911559_gene1759	2.55e-76	251.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,2JPID@204441|Rhodospirillales	204441|Rhodospirillales	T	signal transduction histidine kinase	-	-	2.7.13.3	ko:K13587	ko02020,ko04112,map02020,map04112	M00512	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS_4,PAS_8,PAS_9,Response_reg
k59_446826_2	658655.HMPREF0988_01243	1.69e-21	92.4	COG0760@1|root,COG0760@2|Bacteria,1V5Q2@1239|Firmicutes,248JQ@186801|Clostridia,27IHM@186928|unclassified Lachnospiraceae	186801|Clostridia	O	PPIC-type PPIASE domain	prsA2	-	5.2.1.8	ko:K03769,ko:K07533	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3
k59_947171_2	1128398.Curi_c13140	3.97e-09	57.8	COG0745@1|root,COG0745@2|Bacteria,1TPWS@1239|Firmicutes,25AZ2@186801|Clostridia,2691N@186813|unclassified Clostridiales	186801|Clostridia	KT	Transcriptional regulatory protein, C terminal	phoP	-	-	ko:K02483,ko:K07658,ko:K07668	ko02020,map02020	M00434,M00459	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_279984_1	1379270.AUXF01000001_gene2419	4.05e-09	58.9	COG1529@1|root,COG1529@2|Bacteria,1ZSUN@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C2
k59_279984_2	1166018.FAES_1954	4.98e-31	114.0	COG2080@1|root,COG2080@2|Bacteria,4NM72@976|Bacteroidetes,47XN3@768503|Cytophagia	976|Bacteroidetes	C	[2Fe-2S] binding domain	-	-	1.3.99.16	ko:K07302	-	-	-	-	ko00000,ko01000	-	-	-	Fer2,Fer2_2
k59_168832_1	1028307.EAE_05260	1.06e-17	80.5	COG1028@1|root,COG1028@2|Bacteria,1MV44@1224|Proteobacteria,1RQMT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	-	ko:K18333	ko00051,ko01120,map00051,map01120	-	R08926	RC00066	ko00000,ko00001	-	-	-	adh_short_C2
k59_168832_2	886293.Sinac_4051	5.57e-17	83.2	COG0515@1|root,COG0515@2|Bacteria,2IXG3@203682|Planctomycetes	203682|Planctomycetes	KLT	Serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
k59_557914_1	667632.KB890217_gene4907	3.82e-113	342.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2WBXC@28216|Betaproteobacteria,1K1YX@119060|Burkholderiaceae	28216|Betaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
k59_1725441_2	1304275.C41B8_18186	2.87e-29	116.0	COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,1SYHR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin
k59_1503071_2	1317118.ATO8_00805	9.45e-26	103.0	COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,2TS3N@28211|Alphaproteobacteria,4KKBM@93682|Roseivivax	28211|Alphaproteobacteria	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
k59_1169544_1	40571.JOEA01000028_gene5552	3.03e-39	145.0	COG1668@1|root,COG1668@2|Bacteria,2I9MY@201174|Actinobacteria,4DYBQ@85010|Pseudonocardiales	201174|Actinobacteria	CP	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
k59_446882_1	187272.Mlg_0261	1.35e-40	154.0	COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,1RPTP@1236|Gammaproteobacteria,1WVV2@135613|Chromatiales	135613|Chromatiales	C	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppc	-	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase
k59_891671_1	1116232.AHBF01000077_gene8015	5.99e-14	73.6	COG3940@1|root,COG3940@2|Bacteria,2GJJP@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 43 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_43,RicinB_lectin_2
k59_280026_1	351348.Maqu_1721	1.12e-98	297.0	COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,1RNB3@1236|Gammaproteobacteria,46BCB@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	Transposase, Mutator family	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_1614224_1	1089550.ATTH01000001_gene1475	2.04e-24	108.0	COG2931@1|root,COG2931@2|Bacteria,4NFV5@976|Bacteroidetes,1FJUV@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	Q	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
k59_891683_1	883.DvMF_1520	2.6e-30	111.0	COG3260@1|root,COG3260@2|Bacteria,1QUBE@1224|Proteobacteria,42NH3@68525|delta/epsilon subdivisions,2WNT3@28221|Deltaproteobacteria,2MB7H@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Belongs to the complex I 20 kDa subunit family	-	-	-	ko:K14088	-	-	-	-	ko00000	-	-	-	Oxidored_q6
k59_891683_2	323259.Mhun_1742	1.86e-19	88.6	COG0650@1|root,arCOG01545@2157|Archaea,2XXQ2@28890|Euryarchaeota,2N9NC@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM respiratory-chain NADH dehydrogenase, subunit 1	echB	-	-	ko:K14087	-	-	-	-	ko00000	-	-	-	NADHdh
k59_1725475_1	1333998.M2A_0557	8.27e-71	231.0	COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,2TRQ2@28211|Alphaproteobacteria,4BPB8@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	CP	Proton-conducting membrane transporter	nuoN2	-	1.6.5.3	ko:K00343,ko:K05568	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko02000	2.A.63.1,2.A.63.2,3.D.1	-	-	Proton_antipo_M
k59_2185_1	1461577.CCMH01000018_gene378	9.73e-39	140.0	COG0714@1|root,COG0714@2|Bacteria,4NDVZ@976|Bacteroidetes,1HWNM@117743|Flavobacteriia	976|Bacteroidetes	S	ATPase family associated with various cellular activities (AAA)	moxR	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
k59_2185_2	945713.IALB_2057	2.49e-32	120.0	COG1721@1|root,COG1721@2|Bacteria	2|Bacteria	E	protein (some members contain a von Willebrand factor type A (vWA) domain	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF58
k59_1225339_1	1121106.JQKB01000008_gene1417	5.64e-45	160.0	COG0457@1|root,COG0457@2|Bacteria,1N01S@1224|Proteobacteria,2TSR4@28211|Alphaproteobacteria,2JQKI@204441|Rhodospirillales	204441|Rhodospirillales	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_57740_1	749927.AMED_3665	3.15e-07	52.8	COG1309@1|root,COG1309@2|Bacteria,2GMCG@201174|Actinobacteria,4DXQ4@85010|Pseudonocardiales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
k59_57740_2	1206729.BAFZ01000001_gene113	1.56e-15	77.4	COG0451@1|root,COG0451@2|Bacteria,2GNH5@201174|Actinobacteria,4FXYR@85025|Nocardiaceae	201174|Actinobacteria	GM	NAD dependent epimerase/dehydratase family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
k59_168898_1	177437.HRM2_32950	2.79e-14	77.4	COG0697@1|root,COG0697@2|Bacteria,1QWNP@1224|Proteobacteria,43BTP@68525|delta/epsilon subdivisions,2X74K@28221|Deltaproteobacteria,2MMA8@213118|Desulfobacterales	28221|Deltaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_502463_1	102129.Lepto7375DRAFT_7817	7.36e-25	108.0	COG1680@1|root,COG1680@2|Bacteria,1G5Z2@1117|Cyanobacteria,1HHDZ@1150|Oscillatoriales	1117|Cyanobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_2202_2	929703.KE386491_gene1068	2.99e-57	186.0	COG0179@1|root,COG0179@2|Bacteria,4NFMZ@976|Bacteroidetes,47N4F@768503|Cytophagia	976|Bacteroidetes	Q	PFAM fumarylacetoacetate (FAA) hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
k59_835993_2	324925.Ppha_2924	6.12e-08	50.4	COG0230@1|root,COG0230@2|Bacteria	2|Bacteria	J	Ribosomal protein L34	rpmH	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
k59_1725494_1	671143.DAMO_2129	7.26e-41	148.0	COG0501@1|root,COG0501@2|Bacteria,2NP9X@2323|unclassified Bacteria	2|Bacteria	O	CAAX prenyl protease N-terminal, five membrane helices	agmM	-	3.4.24.84	ko:K06013	ko00900,ko01130,map00900,map01130	-	R09845	RC00141	ko00000,ko00001,ko01000,ko01002,ko04147	-	-	-	Peptidase_M48,Peptidase_M48_N
k59_780436_1	383372.Rcas_1888	7.23e-69	223.0	COG1960@1|root,COG1960@2|Bacteria,2G6E5@200795|Chloroflexi,3763W@32061|Chloroflexia	32061|Chloroflexia	C	PFAM acyl-CoA dehydrogenase domain protein	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_1558756_1	1244869.H261_18797	1.18e-22	99.0	COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,2U0WS@28211|Alphaproteobacteria,2JQ4U@204441|Rhodospirillales	204441|Rhodospirillales	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
k59_1558756_2	1168059.KB899087_gene191	0.000113	44.7	COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,2TQSV@28211|Alphaproteobacteria,3EY8W@335928|Xanthobacteraceae	28211|Alphaproteobacteria	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
k59_224472_1	98439.AJLL01000006_gene4578	3.05e-91	295.0	COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,1G2UN@1117|Cyanobacteria,1JHZY@1189|Stigonemataceae	1117|Cyanobacteria	G	Maltogenic Amylase, C-terminal domain	-	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	APH,Alpha-amylase,Malt_amylase_C
k59_1503131_1	472759.Nhal_2009	8.73e-35	134.0	COG4783@1|root,COG4783@2|Bacteria,1RAJB@1224|Proteobacteria,1SA1F@1236|Gammaproteobacteria,1X0C0@135613|Chromatiales	135613|Chromatiales	S	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
k59_724979_1	983545.Glaag_3941	1.07e-72	239.0	COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,1RM95@1236|Gammaproteobacteria,465BW@72275|Alteromonadaceae	1236|Gammaproteobacteria	I	Acetyl propionyl-CoA carboxylase, alpha subunit	mccA	-	6.4.1.4,6.4.1.5	ko:K01968,ko:K13777	ko00280,ko00281,ko01100,map00280,map00281,map01100	M00036	R03494,R04138	RC00367,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
k59_335618_1	1499967.BAYZ01000020_gene5232	1.46e-06	49.7	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	ko:K17241	ko02010,map02010	M00600	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.39	-	-	SBP_bac_1,SBP_bac_8
k59_335618_2	649638.Trad_1444	7.09e-70	223.0	COG1175@1|root,COG1175@2|Bacteria,1WMCM@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K17242,ko:K17245	ko02010,map02010	M00600,M00601	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.39,3.A.1.1.40	-	-	BPD_transp_1
k59_1336419_1	1267005.KB911256_gene2122	4.76e-18	89.4	COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,2TT3G@28211|Alphaproteobacteria,3N882@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	TonB dependent receptor	-	-	-	ko:K16092	-	-	-	-	ko00000,ko02000	1.B.14.3	-	-	Plug,TonB_dep_Rec
k59_836042_1	1304885.AUEY01000013_gene3127	3.81e-107	322.0	COG1914@1|root,COG1914@2|Bacteria,1MW6X@1224|Proteobacteria,42PNI@68525|delta/epsilon subdivisions,2WJNF@28221|Deltaproteobacteria,2MQ1R@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Natural resistance-associated macrophage protein	mntH	-	-	ko:K03322	-	-	-	-	ko00000,ko02000	2.A.55.2.6,2.A.55.3	-	-	Nramp,Usp
k59_1725548_1	1120972.AUMH01000005_gene903	1.08e-05	53.1	COG4913@1|root,COG4913@2|Bacteria,1TPVZ@1239|Firmicutes,4HETE@91061|Bacilli	91061|Bacilli	S	Putative exonuclease SbcCD, C subunit	-	-	-	-	-	-	-	-	-	-	-	-	AAA_29,SbcCD_C
k59_1447741_1	523791.Kkor_0153	2.85e-74	229.0	COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,1RMIZ@1236|Gammaproteobacteria,1XH7Z@135619|Oceanospirillales	135619|Oceanospirillales	K	COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	Crp,HTH_Crp_2,cNMP_binding
k59_224522_1	1203622.HMPREF1290_01223	1.75e-46	158.0	COG1024@1|root,COG1024@2|Bacteria,2GJW5@201174|Actinobacteria,22KAX@1653|Corynebacteriaceae	201174|Actinobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	echA8	GO:0003674,GO:0003824,GO:0004300,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019752,GO:0030258,GO:0030312,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:1901575	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
k59_1058444_1	1206729.BAFZ01000004_gene976	6.28e-21	92.0	COG2128@1|root,COG2128@2|Bacteria,2ICVV@201174|Actinobacteria,4FZFJ@85025|Nocardiaceae	201174|Actinobacteria	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
k59_170515_2	1268635.Loa_01938	4.48e-06	48.5	COG0036@1|root,COG0036@2|Bacteria,1MUZM@1224|Proteobacteria,1RN3K@1236|Gammaproteobacteria,1JCQH@118969|Legionellales	118969|Legionellales	G	Ribulose-phosphate 3 epimerase family	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
k59_782073_2	926569.ANT_16350	1.15e-24	102.0	COG0449@1|root,COG0449@2|Bacteria,2G5T5@200795|Chloroflexi	200795|Chloroflexi	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
k59_1171190_1	1340493.JNIF01000004_gene715	1.97e-06	45.1	COG2801@1|root,COG2801@2|Bacteria	2|Bacteria	L	transposition	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1171190_2	987059.RBXJA2T_03536	1.05e-46	152.0	COG2963@1|root,COG2963@2|Bacteria,1N1AA@1224|Proteobacteria,2VU5U@28216|Betaproteobacteria,1KPJR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	COG2963 Transposase and inactivated derivatives	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_1227190_1	706587.Desti_1526	1.26e-60	200.0	COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,42MN3@68525|delta/epsilon subdivisions,2WMHC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
k59_739991_1	935840.JAEQ01000004_gene647	2.85e-80	248.0	COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,2TRXZ@28211|Alphaproteobacteria,43QYM@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	COG1116 ABC-type nitrate sulfonate bicarbonate transport system, ATPase component	MA20_38195	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
k59_627833_1	138119.DSY3124	1.13e-16	74.7	COG0537@1|root,COG0537@2|Bacteria,1V9ZJ@1239|Firmicutes,24JCW@186801|Clostridia,262CU@186807|Peptococcaceae	186801|Clostridia	FG	PFAM Histidine triad (HIT) protein	hinT	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
k59_627833_2	443144.GM21_3793	1.3e-26	98.6	COG0828@1|root,COG0828@2|Bacteria,1MZCC@1224|Proteobacteria,42V6T@68525|delta/epsilon subdivisions,2WRAX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Belongs to the bacterial ribosomal protein bS21 family	rpsU	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904	-	ko:K02970	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S21
k59_1072991_1	1121106.JQKB01000003_gene2590	7.94e-57	189.0	COG1304@1|root,COG1304@2|Bacteria,1MUEZ@1224|Proteobacteria,2TU4F@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	FMN-dependent dehydrogenase	MA20_37755	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FMN_dh
k59_962069_1	948106.AWZT01000020_gene4095	3.8e-58	200.0	COG0323@1|root,COG0323@2|Bacteria,1R57G@1224|Proteobacteria,2VP7W@28216|Betaproteobacteria,1K86N@119060|Burkholderiaceae	28216|Betaproteobacteria	L	DNA mismatch repair	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_3
k59_72383_1	525897.Dbac_0900	8.94e-40	140.0	COG4262@1|root,COG4262@2|Bacteria,1PC06@1224|Proteobacteria,42U5M@68525|delta/epsilon subdivisions,2WQRR@28221|Deltaproteobacteria,2MGK6@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	-	-	-	-	-	-	-	-	-	-	Spermine_synth
k59_183280_1	386456.JQKN01000001_gene2091	2.12e-46	154.0	COG3832@1|root,arCOG05261@2157|Archaea	2157|Archaea	H	Activator of Hsp90 ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
k59_183280_2	208444.JNYY01000011_gene3082	2.16e-10	57.8	COG0640@1|root,COG0640@2|Bacteria,2IHS2@201174|Actinobacteria,4E54D@85010|Pseudonocardiales	201174|Actinobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
k59_1573516_1	710686.Mycsm_01832	2.41e-42	152.0	COG2358@1|root,COG2358@2|Bacteria,2I9QR@201174|Actinobacteria	201174|Actinobacteria	S	NMT1-like family	-	-	-	-	-	-	-	-	-	-	-	-	NMT1_3
k59_684841_1	991905.SL003B_2301	7.22e-74	234.0	COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,2TRP9@28211|Alphaproteobacteria,4BPE6@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	P	TrkA-C domain	trkA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
k59_1684717_2	37919.EP51_32895	9.78e-143	425.0	COG3119@1|root,COG3119@2|Bacteria,2GJ8H@201174|Actinobacteria,4FURR@85025|Nocardiaceae	201174|Actinobacteria	P	Arylsulfatase	atsB	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	DUF1269,Sulfatase
k59_17231_1	856793.MICA_1	1.49e-108	326.0	COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,2TQQV@28211|Alphaproteobacteria,4BPHG@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
k59_17231_2	582402.Hbal_3150	6.12e-15	73.2	COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,2TSMS@28211|Alphaproteobacteria,43WGS@69657|Hyphomonadaceae	28211|Alphaproteobacteria	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
k59_127332_1	521674.Plim_1506	2.22e-22	94.7	COG4803@1|root,COG4803@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1269
k59_1351160_1	1122927.KB895415_gene4491	4.69e-88	268.0	COG2309@1|root,COG2309@2|Bacteria,1TP65@1239|Firmicutes,4HBUQ@91061|Bacilli,26SBU@186822|Paenibacillaceae	91061|Bacilli	E	aminopeptidase	ampS5	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
k59_1018231_1	1448389.BAVQ01000035_gene788	1.57e-64	218.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria	201174|Actinobacteria	P	Heavy metal translocating P-type atpase	copB	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase
k59_627883_1	34506.g2925	4.64e-33	131.0	COG0584@1|root,KOG2258@2759|Eukaryota	2759|Eukaryota	C	glycerophosphodiester phosphodiesterase activity	-	-	-	-	-	-	-	-	-	-	-	-	GDPD
k59_349966_1	1265505.ATUG01000002_gene1969	1.81e-21	93.2	COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,42N81@68525|delta/epsilon subdivisions,2WJB0@28221|Deltaproteobacteria,2MIV2@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
k59_349966_2	1379270.AUXF01000002_gene1585	7.95e-45	162.0	COG0515@1|root,COG0515@2|Bacteria,1ZUMJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
k59_72445_1	1189620.AJXL01000009_gene2212	7.77e-75	249.0	COG1629@1|root,COG4206@1|root,COG4206@2|Bacteria,COG4771@2|Bacteria,4NDU8@976|Bacteroidetes,1HXFM@117743|Flavobacteriia,2P0KH@237|Flavobacterium	976|Bacteroidetes	P	TonB-dependent outer membrane receptor, SusC RagA subfamily, signature region	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
k59_1684751_1	1121406.JAEX01000002_gene908	3.23e-08	60.1	COG4963@1|root,COG4963@2|Bacteria,1MWNY@1224|Proteobacteria,42QEH@68525|delta/epsilon subdivisions,2WKVC@28221|Deltaproteobacteria,2MAS2@213115|Desulfovibrionales	28221|Deltaproteobacteria	U	AAA domain	-	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	AAA_31,CBP_BcsQ,ParA,Response_reg
k59_462457_1	580332.Slit_0816	2.75e-25	100.0	COG3090@1|root,COG3090@2|Bacteria,1PJMD@1224|Proteobacteria,2VYB1@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
k59_462457_2	1049564.TevJSym_aa02510	2e-22	95.9	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,1RNAM@1236|Gammaproteobacteria,1J544@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	G	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_850165_2	926569.ANT_05280	1.3e-40	143.0	COG1845@1|root,COG1845@2|Bacteria,2G74U@200795|Chloroflexi	200795|Chloroflexi	C	PFAM cytochrome c oxidase, subunit III	-	-	1.9.3.1	ko:K02276,ko:K02299	ko00190,ko01100,map00190,map01100	M00155,M00417	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.5,3.D.4.6	-	-	COX3
k59_183342_1	1121448.DGI_2945	2.93e-43	155.0	COG0577@1|root,COG0577@2|Bacteria,1MWBK@1224|Proteobacteria,42PZC@68525|delta/epsilon subdivisions,2WK59@28221|Deltaproteobacteria,2M9AF@213115|Desulfovibrionales	28221|Deltaproteobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_627912_1	1226994.AMZB01000088_gene922	1.95e-24	98.6	COG4454@1|root,COG4454@2|Bacteria,1N7A1@1224|Proteobacteria,1SE2P@1236|Gammaproteobacteria,1YKJS@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	P	Copper binding proteins, plastocyanin/azurin family	cusF	-	-	-	-	-	-	-	-	-	-	-	Copper-bind
k59_517507_1	648996.Theam_0684	4.57e-36	139.0	COG1966@1|root,COG1966@2|Bacteria,2G4H1@200783|Aquificae	200783|Aquificae	T	PFAM Carbon starvation protein CstA	cstA	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007154,GO:0008150,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031667,GO:0031668,GO:0031669,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051716,GO:0071496,GO:0071944	-	ko:K06200	-	-	-	-	ko00000	-	-	-	CstA,CstA_5TM
k59_740092_1	322710.Avin_11870	2.19e-20	95.9	COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,1RPV3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	NU	Tfp pilus assembly protein tip-associated adhesin PilY1	pilY1	-	-	ko:K02674	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Neisseria_PilC,VWA_2
k59_1684784_1	1459636.NTE_01283	1.67e-93	300.0	COG0013@1|root,arCOG01255@2157|Archaea,41SBJ@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
k59_1018299_1	1232683.ADIMK_0681	2.49e-50	174.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,1RN6J@1236|Gammaproteobacteria,4641I@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysK	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	Glutaredoxin,PALP
k59_795592_1	1451261.AS96_06425	5.87e-11	68.2	COG0507@1|root,COG0507@2|Bacteria	2|Bacteria	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD	-	-	-	-	-	-	-	-	-	-	-	-	AAA_30,PDDEXK_1,TrwC,UvrD-helicase,UvrD_C
k59_795593_1	1278073.MYSTI_02101	0.000453	45.8	COG3576@1|root,COG3576@2|Bacteria,1MWG9@1224|Proteobacteria	1224|Proteobacteria	Q	flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase	-	-	-	ko:K07006	-	-	-	-	ko00000	-	-	-	Putative_PNPOx
k59_295093_2	316274.Haur_2123	3.43e-58	193.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	ko:K02529,ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022,ko03000	-	-	-	HTH_18,HTH_AraC,Response_reg
k59_239602_1	1416759.AYMR01000011_gene391	4.78e-14	74.7	COG0789@1|root,COG1225@1|root,COG0789@2|Bacteria,COG1225@2|Bacteria,2IIEZ@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MerR,MerR-DNA-bind,MerR_1,Redoxin
k59_239602_2	1229780.BN381_130164	4.04e-08	50.8	COG2608@1|root,COG2608@2|Bacteria	2|Bacteria	P	mercury ion transmembrane transporter activity	copZ	-	-	ko:K07213	ko04978,map04978	-	-	-	ko00000,ko00001	-	-	-	HMA
k59_1073108_2	1202768.JROF01000015_gene1111	2.36e-16	80.9	COG3119@1|root,arCOG02787@2157|Archaea,2XUWX@28890|Euryarchaeota,23S64@183963|Halobacteria	183963|Halobacteria	P	COG3119 Arylsulfatase A and related enzymes	-	-	3.1.6.1,3.1.6.6	ko:K01130,ko:K01133	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_684944_1	1382306.JNIM01000001_gene4155	5.09e-66	213.0	COG0057@1|root,COG0057@2|Bacteria,2G5MG@200795|Chloroflexi	200795|Chloroflexi	C	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gap	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
k59_1406999_1	1114959.SZMC14600_12822	9.65e-44	146.0	COG4977@1|root,COG4977@2|Bacteria,2I3BT@201174|Actinobacteria,4E409@85010|Pseudonocardiales	201174|Actinobacteria	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
k59_1406999_2	656024.FsymDg_3526	3.49e-63	196.0	COG0346@1|root,COG0346@2|Bacteria,2IG0S@201174|Actinobacteria,4EVCE@85013|Frankiales	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
k59_462522_1	1121017.AUFG01000023_gene2145	1.64e-23	107.0	COG1196@1|root,COG1196@2|Bacteria,2GK93@201174|Actinobacteria,4FFAB@85021|Intrasporangiaceae	201174|Actinobacteria	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
k59_517543_1	443144.GM21_1757	3.44e-27	117.0	COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,42M1S@68525|delta/epsilon subdivisions,2WJ02@28221|Deltaproteobacteria,43U7Y@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	PFAM penicillin-binding protein transpeptidase	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	iAF987.Gmet_0928	PBP_dimer,Transpeptidase
k59_295109_1	195253.Syn6312_1429	9.39e-47	167.0	COG3004@1|root,COG3004@2|Bacteria	2|Bacteria	P	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons	nhaA	-	-	ko:K03313	-	-	-	-	ko00000,ko02000	2.A.33.1	-	-	Na_H_antiport_1
k59_72515_2	351016.RAZWK3B_16695	6.05e-12	65.1	28Z71@1|root,2ZKZ8@2|Bacteria,1P4MH@1224|Proteobacteria,2UXS6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1351255_1	281090.Lxx15880	1.41e-31	120.0	COG1974@1|root,COG1974@2|Bacteria,2GMBN@201174|Actinobacteria,4FKD4@85023|Microbacteriaceae	201174|Actinobacteria	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
k59_1462721_1	1095769.CAHF01000005_gene1513	6.77e-08	55.1	COG0637@1|root,COG0637@2|Bacteria,1NSPA@1224|Proteobacteria,2VH6V@28216|Betaproteobacteria	28216|Betaproteobacteria	S	TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
k59_1462721_2	394.NGR_c27120	4.82e-27	107.0	COG0697@1|root,COG0697@2|Bacteria,1MVGC@1224|Proteobacteria,2TS6Y@28211|Alphaproteobacteria,4B9EV@82115|Rhizobiaceae	28211|Alphaproteobacteria	EG	of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_1241648_1	909663.KI867150_gene1759	8.14e-08	52.8	COG1550@1|root,COG1550@2|Bacteria,1NBXZ@1224|Proteobacteria,42W9E@68525|delta/epsilon subdivisions,2WRK0@28221|Deltaproteobacteria,2MQR4@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF503)	-	-	-	ko:K09764	-	-	-	-	ko00000	-	-	-	DUF503
k59_1241648_2	1121943.KB899997_gene1720	2.48e-22	94.4	COG1893@1|root,COG1893@2|Bacteria,1MX5M@1224|Proteobacteria,1SZ0M@1236|Gammaproteobacteria,1XKZK@135619|Oceanospirillales	135619|Oceanospirillales	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
k59_517570_1	452637.Oter_0068	1.14e-34	132.0	COG2972@1|root,COG2972@2|Bacteria,46XGC@74201|Verrucomicrobia,3K8E3@414999|Opitutae	414999|Opitutae	T	Signal transduction histidine kinase, LytS	-	-	2.7.13.3	ko:K02478	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HATPase_c,His_kinase
k59_517570_2	591167.Sfla_5828	6.36e-10	59.3	COG2197@1|root,COG2197@2|Bacteria,2GN80@201174|Actinobacteria	201174|Actinobacteria	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_1407042_1	266779.Meso_1074	2.27e-93	284.0	COG4948@1|root,COG4948@2|Bacteria,1MURK@1224|Proteobacteria,2U10C@28211|Alphaproteobacteria,43NJ7@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	M	mandelate racemase muconate lactonizing	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
k59_1295473_1	1894.JOER01000089_gene1754	1.55e-08	60.8	COG4292@1|root,COG4292@2|Bacteria,2GJPB@201174|Actinobacteria	201174|Actinobacteria	S	Low temperature requirement	-	-	-	-	-	-	-	-	-	-	-	-	LtrA
k59_1295473_2	861299.J421_0693	6.48e-26	100.0	COG0778@1|root,COG0778@2|Bacteria,1ZTKQ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
k59_795664_1	931277.C448_03921	4.26e-26	112.0	COG0661@1|root,arCOG01189@2157|Archaea,2XT2I@28890|Euryarchaeota,23S8M@183963|Halobacteria	183963|Halobacteria	S	unusual protein kinase	ubiB	-	-	-	-	-	-	-	-	-	-	-	ABC1
k59_795669_1	75379.Tint_0707	1.01e-33	121.0	COG2010@1|root,COG2010@2|Bacteria,1N0EF@1224|Proteobacteria,2VT6G@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Cytochrome c mono- and diheme variants	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
k59_962291_1	926569.ANT_09980	3.76e-79	262.0	COG0085@1|root,COG0085@2|Bacteria,2G5VH@200795|Chloroflexi	200795|Chloroflexi	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_17391_1	861299.J421_1876	1.41e-98	303.0	COG3386@1|root,COG3386@2|Bacteria	2|Bacteria	G	gluconolactonase activity	-	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	SGL
k59_1684912_2	886293.Sinac_3291	1.24e-22	94.0	COG4636@1|root,COG4636@2|Bacteria,2J0XX@203682|Planctomycetes	203682|Planctomycetes	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
k59_295169_1	296587.XP_002507415.1	9.73e-37	132.0	2EIJQ@1|root,2SNYZ@2759|Eukaryota	2759|Eukaryota	S	UreE urease accessory protein, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	UDG
k59_1407083_1	671143.DAMO_2607	3.86e-108	323.0	COG1260@1|root,COG1260@2|Bacteria,2NP2I@2323|unclassified Bacteria	2|Bacteria	I	Myo-inositol-1-phosphate synthase	ino1	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth,NAD_binding_5
k59_296980_1	335543.Sfum_1368	1.35e-21	93.2	COG1399@1|root,COG1399@2|Bacteria,1N7GQ@1224|Proteobacteria,42U2P@68525|delta/epsilon subdivisions,2WRMV@28221|Deltaproteobacteria,2MS4U@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Uncharacterized ACR, COG1399	-	-	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF177
k59_1297490_1	316274.Haur_3213	1.99e-64	220.0	COG1009@1|root,COG1009@2|Bacteria,2G5NJ@200795|Chloroflexi,3759P@32061|Chloroflexia	32061|Chloroflexia	C	PFAM NADH-Ubiquinone oxidoreductase (complex I), chain 5 L domain protein	-	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
k59_74386_1	864051.BurJ1DRAFT_3279	3.56e-88	271.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2VQF1@28216|Betaproteobacteria,1KPGZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve
k59_74386_2	1123236.KB899395_gene3150	2.79e-23	92.4	COG2963@1|root,COG2963@2|Bacteria,1N28U@1224|Proteobacteria,1S9BK@1236|Gammaproteobacteria,46B8H@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	Transposase	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_1686841_1	479434.Sthe_2945	3.49e-19	91.7	COG1914@1|root,COG1914@2|Bacteria,2GBWI@200795|Chloroflexi,27Z1D@189775|Thermomicrobia	189775|Thermomicrobia	P	H( )-stimulated, divalent metal cation uptake system	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_408238_1	1249627.D779_0453	4.35e-29	120.0	COG3437@1|root,COG3437@2|Bacteria,1R0ZH@1224|Proteobacteria,1S4GZ@1236|Gammaproteobacteria,1X0BF@135613|Chromatiales	135613|Chromatiales	KT	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD_5,PAS_4
k59_797541_1	342113.DM82_2288	2.37e-33	132.0	COG4584@1|root,COG4584@2|Bacteria,1MU2G@1224|Proteobacteria,2VMEU@28216|Betaproteobacteria,1K5F3@119060|Burkholderiaceae	28216|Betaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_241397_1	627192.SLG_03500	2.27e-39	139.0	COG0135@1|root,COG0135@2|Bacteria,1RA5Q@1224|Proteobacteria,2U5E8@28211|Alphaproteobacteria,2K4HX@204457|Sphingomonadales	204457|Sphingomonadales	E	N-(5'phosphoribosyl)anthranilate (PRA) isomerase	-	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
k59_241397_2	316056.RPC_4871	0.000883	41.6	COG0076@1|root,COG0076@2|Bacteria,1MWUX@1224|Proteobacteria,2TTUK@28211|Alphaproteobacteria,3JV5F@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Pyridoxal-dependent decarboxylase conserved domain	MA20_08345	-	4.1.1.105,4.1.1.28	ko:K01593	ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00037,M00042	R00685,R00699,R00736,R02080,R02701,R04909	RC00299	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyridoxal_deC
k59_1186395_1	314231.FP2506_05711	1.33e-53	185.0	COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,2TRPB@28211|Alphaproteobacteria,2PJFF@255475|Aurantimonadaceae	28211|Alphaproteobacteria	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3,DUF3646
k59_519456_1	457396.CSBG_01352	9e-22	96.7	COG1171@1|root,COG1171@2|Bacteria,1TP22@1239|Firmicutes,248D5@186801|Clostridia,36E9R@31979|Clostridiaceae	186801|Clostridia	E	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA	ilvA	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PALP
k59_797562_1	313596.RB2501_07440	2.41e-92	276.0	COG2908@1|root,COG2908@2|Bacteria,4NEF1@976|Bacteroidetes,1HWZZ@117743|Flavobacteriia	976|Bacteroidetes	S	UDP-2,3-diacylglucosamine hydrolase	lpxH	-	3.6.1.54	ko:K03269	ko00540,ko01100,map00540,map01100	M00060	R04549	RC00002	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Metallophos,Metallophos_2
k59_974488_1	518766.Rmar_0690	3.79e-57	191.0	COG1457@1|root,COG1457@2|Bacteria,4NHHC@976|Bacteroidetes	976|Bacteroidetes	F	Belongs to the purine-cytosine permease (2.A.39) family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_806958_1	272942.RCAP_rcc02982	1.98e-46	162.0	COG0287@1|root,COG0287@2|Bacteria,1QTZA@1224|Proteobacteria,2TS12@28211|Alphaproteobacteria,1FAT1@1060|Rhodobacter	28211|Alphaproteobacteria	E	PFAM Prephenate dehydrogenase	tyrC	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008977,GO:0009058,GO:0009072,GO:0009073,GO:0009095,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019438,GO:0019752,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046983,GO:0047794,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.3.1.12,1.3.1.43	ko:K00210,ko:K00220,ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025,M00040	R00732,R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	PDH
k59_639142_1	926550.CLDAP_24510	5.59e-60	209.0	COG2273@1|root,COG2273@2|Bacteria,2G7RY@200795|Chloroflexi	200795|Chloroflexi	G	Glycoside hydrolase family 16	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_16
k59_1585363_1	862751.SACTE_5619	6.76e-85	271.0	COG2838@1|root,COG2838@2|Bacteria,2GJ1C@201174|Actinobacteria	201174|Actinobacteria	C	Isocitrate dehydrogenase	icd	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	IDH
k59_250553_1	1410634.JHVD01000010_gene2420	1.45e-36	138.0	COG1929@1|root,COG1929@2|Bacteria,2GKHX@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the glycerate kinase type-1 family	glxK	-	2.7.1.165	ko:K00865	ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130	-	R08572	RC00002,RC00428	ko00000,ko00001,ko01000	-	-	-	Gly_kinase
k59_696574_2	1123024.AUII01000009_gene1950	3.38e-72	235.0	COG1024@1|root,COG1024@2|Bacteria,2GMNR@201174|Actinobacteria,4E08J@85010|Pseudonocardiales	201174|Actinobacteria	I	Enoyl-CoA hydratase/isomerase	boxC	-	4.1.2.44	ko:K15513	ko00362,map00362	-	R09556	RC03426	ko00000,ko00001,ko01000	-	-	-	ECH_1
k59_1418243_1	298655.KI912266_gene30	9.77e-98	290.0	COG0388@1|root,COG0388@2|Bacteria,2GKRJ@201174|Actinobacteria	201174|Actinobacteria	S	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	3.5.1.6	ko:K01431	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R00905,R04666,R08228	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase
k59_1529466_2	316274.Haur_4823	7.72e-58	195.0	COG1109@1|root,COG1109@2|Bacteria,2G5Y4@200795|Chloroflexi	200795|Chloroflexi	G	phosphoglucomutase phosphomannomutase alpha beta alpha domain I	-	-	5.4.2.8	ko:K01840	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01818	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_1307929_1	448385.sce8970	1.54e-45	161.0	COG1819@1|root,COG1819@2|Bacteria,1MVI7@1224|Proteobacteria,42UK8@68525|delta/epsilon subdivisions,2WQG7@28221|Deltaproteobacteria,2Z0U2@29|Myxococcales	28221|Deltaproteobacteria	CG	UDP-glucoronosyl and UDP-glucosyl transferase	-	-	2.4.1.310	ko:K16444	ko01055,map01055	-	-	-	ko00000,ko00001,ko01000	-	GT1	-	Glyco_transf_28,UDPGT
k59_639160_1	1040989.AWZU01000011_gene4004	2.55e-63	196.0	COG0517@1|root,COG0517@2|Bacteria,1Q3MP@1224|Proteobacteria,2UB19@28211|Alphaproteobacteria,3JY0D@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_1639636_1	1185876.BN8_02239	3.29e-38	146.0	COG1520@1|root,COG2010@1|root,COG1520@2|Bacteria,COG2010@2|Bacteria,4NPS4@976|Bacteroidetes,47R6K@768503|Cytophagia	976|Bacteroidetes	C	PQQ-like domain	-	-	1.1.2.6	ko:K05889	-	-	R03136	-	ko00000,ko01000	-	-	-	Cytochrome_CBB3,PQQ,PQQ_2,PQQ_3
k59_1085158_1	857087.Metme_2457	2.31e-52	174.0	COG1733@1|root,COG1733@2|Bacteria,1PGWN@1224|Proteobacteria,1SXVP@1236|Gammaproteobacteria,1XGTB@135618|Methylococcales	135618|Methylococcales	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
k59_920042_1	867902.Ornrh_1857	1.23e-51	177.0	COG0015@1|root,COG0015@2|Bacteria,4NFY8@976|Bacteroidetes,1HXVA@117743|Flavobacteriia	976|Bacteroidetes	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,ASL_C,Lyase_1
k59_1639657_1	1444310.JANV01000095_gene3175	2.19e-71	226.0	COG0673@1|root,COG0673@2|Bacteria,1TP83@1239|Firmicutes,4HAKY@91061|Bacilli,1ZBDM@1386|Bacillus	91061|Bacilli	S	Oxidoreductase family, NAD-binding Rossmann fold	idhA	-	1.1.1.18,1.1.1.369	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	-	R01183,R09951	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_1253463_1	861299.J421_3812	6.18e-94	298.0	COG0296@1|root,COG0296@2|Bacteria,1ZT8Y@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
k59_1585424_1	383372.Rcas_1860	3.79e-57	191.0	COG0303@1|root,COG0303@2|Bacteria,2G6F6@200795|Chloroflexi,376P1@32061|Chloroflexia	32061|Chloroflexia	H	MoeA domain protein domain I and II	-	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
k59_639202_1	1254432.SCE1572_13280	2e-57	189.0	COG3315@1|root,COG3315@2|Bacteria,1REBR@1224|Proteobacteria,42W2V@68525|delta/epsilon subdivisions,2WRPW@28221|Deltaproteobacteria,2YXRE@29|Myxococcales	28221|Deltaproteobacteria	H	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	LCM
k59_1639680_1	483219.LILAB_26565	1.51e-92	286.0	COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,42P6Z@68525|delta/epsilon subdivisions,2WK5W@28221|Deltaproteobacteria,2YUMK@29|Myxococcales	28221|Deltaproteobacteria	G	Maltogenic Amylase, C-terminal domain	treS	-	2.4.1.4,3.2.1.1,5.4.99.16	ko:K05341,ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R01823,R02108,R02112,R11262	RC00028,RC01816	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Malt_amylase_C
k59_1474640_1	485913.Krac_10670	8.88e-42	157.0	COG2197@1|root,COG3903@1|root,COG2197@2|Bacteria,COG3903@2|Bacteria,2G7W3@200795|Chloroflexi	200795|Chloroflexi	K	transcriptional regulator, LuxR family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,GerE,NB-ARC,TPR_12
k59_250626_1	1265505.ATUG01000001_gene3472	7.75e-38	143.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,42N7X@68525|delta/epsilon subdivisions,2WMM9@28221|Deltaproteobacteria,2MMU3@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_1141324_1	268407.PWYN_22775	4.11e-51	173.0	COG0604@1|root,COG0604@2|Bacteria,1TQ0M@1239|Firmicutes,4HA8M@91061|Bacilli,26TF8@186822|Paenibacillaceae	91061|Bacilli	C	NADPH quinone reductase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
k59_1141331_1	1379270.AUXF01000006_gene151	4.92e-41	151.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1ZU89@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	-	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_1141331_2	253839.SSNG_01824	7.27e-05	47.0	COG0737@1|root,COG0737@2|Bacteria,2GKC3@201174|Actinobacteria	201174|Actinobacteria	F	Belongs to the 5'-nucleotidase family	cpdB	-	3.1.3.5,3.1.3.6,3.1.4.16	ko:K01081,ko:K01119	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01562,R01569,R01664,R01877,R01968,R02088,R02102,R02148,R02323,R02370,R02719,R03346,R03537,R03538,R03929,R05135	RC00017,RC00078,RC00296	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,Metallophos
k59_475040_1	1352941.M877_37620	1.56e-35	138.0	COG2409@1|root,COG2409@2|Bacteria,2GJ5A@201174|Actinobacteria	201174|Actinobacteria	F	Drug exporters of the RND superfamily	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	MMPL
k59_1308001_1	172088.AUGA01000047_gene1327	5.01e-28	111.0	COG2079@1|root,COG2079@2|Bacteria,1R5CE@1224|Proteobacteria,2TUP7@28211|Alphaproteobacteria,3JW76@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	MmgE/PrpD family	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
k59_1308001_2	883080.HMPREF9697_03586	1.37e-85	269.0	COG2079@1|root,COG2079@2|Bacteria,1R5CE@1224|Proteobacteria,2TUP7@28211|Alphaproteobacteria,3JW76@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	MmgE/PrpD family	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
k59_807047_1	1287276.X752_05360	1.5e-18	81.3	2EVVN@1|root,33P9B@2|Bacteria,1NKC1@1224|Proteobacteria,2UJTN@28211|Alphaproteobacteria,43MB8@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1141347_1	1206729.BAFZ01000093_gene2214	1.61e-30	124.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4FU1J@85025|Nocardiaceae	201174|Actinobacteria	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_307199_1	234267.Acid_1624	2.3e-10	57.8	COG2963@1|root,COG2963@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	ko:K07483,ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_307199_2	234267.Acid_6069	8.01e-124	361.0	COG2801@1|root,COG2801@2|Bacteria	2|Bacteria	L	transposition	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve,rve_3
k59_361821_1	405948.SACE_0017	6.98e-05	47.8	COG3315@1|root,COG3315@2|Bacteria,2GN89@201174|Actinobacteria	201174|Actinobacteria	Q	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	LCM
k59_807073_1	187272.Mlg_2472	5.46e-49	166.0	COG0604@1|root,COG0604@2|Bacteria,1MWBD@1224|Proteobacteria,1RPCQ@1236|Gammaproteobacteria,1X2AC@135613|Chromatiales	135613|Chromatiales	C	N-terminal domain of oxidoreductase	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_1363225_1	349520.PPE_00731	4.99e-14	79.3	COG1316@1|root,COG1316@2|Bacteria,1TR1B@1239|Firmicutes,4HA09@91061|Bacilli,26RVC@186822|Paenibacillaceae	91061|Bacilli	K	Transcriptional regulator	lytR1	-	-	-	-	-	-	-	-	-	-	-	LytR_cpsA_psr
k59_920127_1	1415779.JOMH01000001_gene3264	3.76e-08	55.5	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,1RMSR@1236|Gammaproteobacteria,1X36C@135614|Xanthomonadales	135614|Xanthomonadales	M	Belongs to the peptidase S41A family	ctp	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
k59_920127_2	1049564.TevJSym_at00270	8.99e-57	192.0	COG4942@1|root,COG4942@2|Bacteria,1MY3E@1224|Proteobacteria,1RPQP@1236|Gammaproteobacteria,1J4S5@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	D	COG4942 Membrane-bound metallopeptidase	envC	GO:0000920,GO:0001896,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008219,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0012501,GO:0016020,GO:0016787,GO:0030288,GO:0030313,GO:0031975,GO:0032153,GO:0042221,GO:0042493,GO:0042546,GO:0042597,GO:0043085,GO:0044085,GO:0044093,GO:0044464,GO:0050790,GO:0050896,GO:0051301,GO:0051336,GO:0051345,GO:0065007,GO:0065009,GO:0071554,GO:0071840,GO:0071944	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_1196370_1	290400.Jann_3791	2.07e-28	116.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQNK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	COG1593 TRAP-type C4-dicarboxylate transport system, large permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_1196370_2	318167.Sfri_2035	2.77e-10	58.9	28M05@1|root,32SJ0@2|Bacteria,1N115@1224|Proteobacteria,1S9ED@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_807080_1	1246995.AFR_11935	5.38e-05	50.8	COG2909@1|root,COG2909@2|Bacteria,2GJXF@201174|Actinobacteria	201174|Actinobacteria	K	luxR family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
k59_361834_1	1380390.JIAT01000013_gene152	4.58e-150	444.0	COG3119@1|root,COG3119@2|Bacteria,2GJ8H@201174|Actinobacteria,4CRY0@84995|Rubrobacteria	84995|Rubrobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_84329_1	118161.KB235922_gene1156	1.21e-16	80.9	COG3854@1|root,COG3854@2|Bacteria,1G0U1@1117|Cyanobacteria,3VI5Y@52604|Pleurocapsales	1117|Cyanobacteria	S	PFAM ATPase family associated with various cellular activities (AAA)	ycf45	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_30,R3H
k59_529123_1	83406.HDN1F_17570	2.54e-105	315.0	COG0446@1|root,COG0446@2|Bacteria,1NR3M@1224|Proteobacteria,1RN6P@1236|Gammaproteobacteria,1J52G@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Reductase C-terminal	-	-	1.18.1.3	ko:K00529	ko00071,ko00360,ko01120,ko01220,map00071,map00360,map01120,map01220	M00545	R02000,R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Pyr_redox_2,Reductase_C
k59_639276_2	761193.Runsl_1887	4.32e-49	159.0	COG0614@1|root,COG0614@2|Bacteria,4NQQ6@976|Bacteroidetes,47R7B@768503|Cytophagia	976|Bacteroidetes	P	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
k59_974634_1	1123057.P872_02555	3.23e-42	156.0	COG1404@1|root,COG1404@2|Bacteria,4NFFV@976|Bacteroidetes,47JYC@768503|Cytophagia	976|Bacteroidetes	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
k59_1253547_1	991905.SL003B_4075	4.51e-46	162.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria	1224|Proteobacteria	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_38,HTH_7,rve
k59_1253547_2	1123229.AUBC01000040_gene3836	1.74e-40	142.0	COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,2TS16@28211|Alphaproteobacteria,3JSGF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	IstB-like ATP binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
k59_974641_1	314285.KT71_11159	5.92e-80	258.0	COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,1RN6Z@1236|Gammaproteobacteria,1J517@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009314,GO:0009380,GO:0009628,GO:0032991,GO:0042802,GO:0044424,GO:0044464,GO:0050896,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
k59_696714_2	926569.ANT_01450	0.000747	40.8	COG2236@1|root,COG2236@2|Bacteria,2G6Y5@200795|Chloroflexi	200795|Chloroflexi	F	Phosphoribosyl transferase domain	-	-	-	ko:K07101	-	-	-	-	ko00000	-	-	-	Pribosyltran
k59_1085297_1	378806.STAUR_5413	1.68e-12	71.6	COG0642@1|root,COG2199@1|root,COG2205@2|Bacteria,COG3706@2|Bacteria,1NRP8@1224|Proteobacteria,4304I@68525|delta/epsilon subdivisions,2WVDN@28221|Deltaproteobacteria,2YWX7@29|Myxococcales	28221|Deltaproteobacteria	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GGDEF,HATPase_c,HisKA,Response_reg
k59_475112_1	1089553.Tph_c18770	3.71e-34	136.0	COG2132@1|root,COG2132@2|Bacteria,1V17J@1239|Firmicutes,24FAM@186801|Clostridia	186801|Clostridia	Q	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	SdrD_B
k59_696727_1	379066.GAU_1116	1.9e-80	243.0	COG1100@1|root,COG1100@2|Bacteria,1ZSQI@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	ADP-ribosylation factor family	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	Arf
k59_1639786_1	999541.bgla_1g38380	4.81e-103	324.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,2VHUF@28216|Betaproteobacteria,1K0Y7@119060|Burkholderiaceae	28216|Betaproteobacteria	L	dna topoisomerase III	topB	-	5.99.1.2	ko:K03169	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	SWIB,Topoisom_bac,Toprim,Toprim_Crpt
k59_195356_2	235909.GK1303	7.75e-18	84.0	COG0621@1|root,COG0621@2|Bacteria,1TNYN@1239|Firmicutes,4HAAS@91061|Bacilli,1WFMP@129337|Geobacillus	91061|Bacilli	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0034470,GO:0034641,GO:0034660,GO:0035596,GO:0035597,GO:0035600,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0050497,GO:0071704,GO:0090304,GO:1901360	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
k59_84363_1	644966.Tmar_0238	6.63e-71	231.0	COG1109@1|root,COG1109@2|Bacteria,1TP1X@1239|Firmicutes,2499P@186801|Clostridia,3WCZC@538999|Clostridiales incertae sedis	186801|Clostridia	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_1585547_1	1280954.HPO_19237	1.21e-32	118.0	COG2963@1|root,COG2963@2|Bacteria,1NH66@1224|Proteobacteria,2UD9V@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Associated with IS66-like transposable element, conserved	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_920185_1	330214.NIDE0307	1.54e-18	89.4	COG4269@1|root,COG4269@2|Bacteria	2|Bacteria	T	membrane	yjgN	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF898
k59_1253585_1	1123401.JHYQ01000022_gene1143	9.16e-56	197.0	COG2010@1|root,COG3031@1|root,COG2010@2|Bacteria,COG3031@2|Bacteria,1NG71@1224|Proteobacteria,1RNZA@1236|Gammaproteobacteria,462PN@72273|Thiotrichales	72273|Thiotrichales	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1697406_1	1297742.A176_04241	4.88e-29	120.0	COG0577@1|root,COG0577@2|Bacteria,1NREW@1224|Proteobacteria	1224|Proteobacteria	V	COG0577 ABC-type antimicrobial peptide transport system permease component	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_1309976_1	926569.ANT_26050	1.92e-36	131.0	COG5433@1|root,COG5433@2|Bacteria,2G91M@200795|Chloroflexi	200795|Chloroflexi	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
k59_862880_1	1168067.JAGP01000001_gene672	1.31e-13	75.9	COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,1RP5S@1236|Gammaproteobacteria,460B5@72273|Thiotrichales	72273|Thiotrichales	S	Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48,TPR_19
k59_1699305_1	1437824.BN940_06796	9.08e-64	201.0	COG1670@1|root,COG1670@2|Bacteria,1MXEE@1224|Proteobacteria,2VKTD@28216|Betaproteobacteria,3T905@506|Alcaligenaceae	28216|Betaproteobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
k59_1087034_1	553385.JEMF01000020_gene3043	2.66e-50	181.0	COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,1RP9N@1236|Gammaproteobacteria,1XHKJ@135619|Oceanospirillales	135619|Oceanospirillales	OT	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	-	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
k59_1587102_1	68170.KL590489_gene10601	1.33e-14	75.5	COG2355@1|root,COG2355@2|Bacteria,2GN82@201174|Actinobacteria,4DX4Y@85010|Pseudonocardiales	201174|Actinobacteria	E	Membrane dipeptidase (Peptidase family M19)	Dpep	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
k59_1143157_1	471852.Tcur_4011	3.94e-39	150.0	COG2902@1|root,COG2902@2|Bacteria,2GK0C@201174|Actinobacteria,4EGYX@85012|Streptosporangiales	201174|Actinobacteria	E	Bacterial NAD-glutamate dehydrogenase	gdh	-	1.4.1.2	ko:K15371	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	-	R00243	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	Bac_GDH
k59_308875_1	706587.Desti_4599	1.83e-96	301.0	COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,42NYT@68525|delta/epsilon subdivisions,2WKSF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
k59_1476329_1	9986.ENSOCUP00000007991	1.64e-47	171.0	COG0165@1|root,KOG1316@2759|Eukaryota,38CSU@33154|Opisthokonta,3BCPR@33208|Metazoa,3CWDR@33213|Bilateria,47Z16@7711|Chordata,48WQS@7742|Vertebrata,3JAT4@40674|Mammalia,359JQ@314146|Euarchontoglires	33208|Metazoa	E	argininosuccinate lyase activity	ASL	GO:0000050,GO:0000053,GO:0001655,GO:0001666,GO:0001822,GO:0001889,GO:0002237,GO:0002376,GO:0003674,GO:0003824,GO:0004056,GO:0005198,GO:0005212,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005739,GO:0005740,GO:0005741,GO:0005783,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006536,GO:0006541,GO:0006575,GO:0006591,GO:0006807,GO:0006950,GO:0006952,GO:0006955,GO:0007275,GO:0007494,GO:0007517,GO:0007568,GO:0007584,GO:0007610,GO:0007626,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009410,GO:0009605,GO:0009607,GO:0009617,GO:0009628,GO:0009636,GO:0009719,GO:0009725,GO:0009791,GO:0009987,GO:0009991,GO:0010033,GO:0010035,GO:0010038,GO:0010043,GO:0010243,GO:0012505,GO:0014070,GO:0014074,GO:0014075,GO:0016020,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019627,GO:0019676,GO:0019740,GO:0019752,GO:0019867,GO:0031090,GO:0031667,GO:0031960,GO:0031966,GO:0031967,GO:0031968,GO:0031975,GO:0032496,GO:0032501,GO:0032502,GO:0032870,GO:0033554,GO:0033762,GO:0033993,GO:0034097,GO:0034341,GO:0034612,GO:0034641,GO:0035295,GO:0035690,GO:0036293,GO:0036294,GO:0036477,GO:0042221,GO:0042450,GO:0042493,GO:0042802,GO:0042995,GO:0043005,GO:0043025,GO:0043204,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043434,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044297,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045087,GO:0046394,GO:0046683,GO:0048471,GO:0048513,GO:0048545,GO:0048565,GO:0048731,GO:0048732,GO:0048856,GO:0050896,GO:0051384,GO:0051591,GO:0051704,GO:0051707,GO:0051716,GO:0055123,GO:0060359,GO:0060416,GO:0060538,GO:0060539,GO:0060541,GO:0061008,GO:0061061,GO:0070482,GO:0070852,GO:0070887,GO:0071242,GO:0071310,GO:0071320,GO:0071345,GO:0071346,GO:0071356,GO:0071375,GO:0071377,GO:0071383,GO:0071384,GO:0071385,GO:0071396,GO:0071407,GO:0071417,GO:0071453,GO:0071456,GO:0071466,GO:0071495,GO:0071548,GO:0071549,GO:0071704,GO:0071941,GO:0072001,GO:0072350,GO:0097327,GO:0097458,GO:0098588,GO:0098805,GO:0120025,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901652,GO:1901653,GO:1901654,GO:1901655,GO:1901698,GO:1901699,GO:1901700,GO:1901701	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
k59_752799_1	926569.ANT_26040	6.48e-37	134.0	COG5433@1|root,COG5433@2|Bacteria,2G91G@200795|Chloroflexi	200795|Chloroflexi	L	DDE_Tnp_1-associated	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_assoc
k59_1364933_1	1380394.JADL01000005_gene5676	6.46e-22	94.4	COG2175@1|root,COG2175@2|Bacteria,1MVI6@1224|Proteobacteria,2TVHF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	PFAM Taurine catabolism dioxygenase TauD, TfdA family	-	-	-	-	-	-	-	-	-	-	-	-	TauD
k59_85747_1	335543.Sfum_0610	9.23e-46	173.0	COG0243@1|root,COG0243@2|Bacteria,1R4RR@1224|Proteobacteria,42PA5@68525|delta/epsilon subdivisions,2WM0K@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	qrcB	-	-	ko:K08357	ko00920,ko01120,ko02020,map00920,map01120,map02020	-	R10150	RC03109	ko00000,ko00001,ko02000	5.A.3.10	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_530660_1	1004149.AFOE01000052_gene261	2.18e-95	300.0	COG1472@1|root,COG1472@2|Bacteria,4NE90@976|Bacteroidetes,1HWVV@117743|Flavobacteriia	976|Bacteroidetes	G	hydrolase, family 3	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Glyco_hydro_3,Glyco_hydro_3_C
k59_922076_2	1121121.KB894307_gene2049	5.01e-17	84.0	COG5379@1|root,COG5379@2|Bacteria,1V1UP@1239|Firmicutes,4HX2Z@91061|Bacilli	91061|Bacilli	I	Protein of unknown function (DUF3419)	-	-	-	ko:K13622	ko00564,map00564	-	R09072	RC00021,RC01091	ko00000,ko00001	-	-	-	DUF3419
k59_922079_1	861299.J421_3951	4.64e-64	207.0	COG0714@1|root,COG0714@2|Bacteria,1ZT5U@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
k59_808790_1	531844.FIC_02468	8.6e-36	137.0	COG0771@1|root,COG0771@2|Bacteria,4NEFF@976|Bacteroidetes,1HX80@117743|Flavobacteriia,4065G@61432|unclassified Flavobacteriaceae	976|Bacteroidetes	M	Mur ligase family, glutamate ligase domain	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
k59_1752682_1	488538.SAR116_1120	5.83e-41	144.0	COG1622@1|root,COG1622@2|Bacteria,1MWHZ@1224|Proteobacteria,2TRK6@28211|Alphaproteobacteria,4BPFA@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	coxB	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM
k59_308911_1	626887.J057_07631	3.59e-78	245.0	COG1653@1|root,COG1653@2|Bacteria,1MX9J@1224|Proteobacteria,1RPYT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	ABC transporter substrate-binding protein	thuE	-	-	ko:K10236	ko02010,map02010	M00204	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.17	-	-	SBP_bac_1,SBP_bac_8
k59_495619_1	649638.Trad_0504	1.91e-14	76.3	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
k59_1658914_1	1120792.JAFV01000001_gene47	3.79e-98	301.0	COG3666@1|root,COG3666@2|Bacteria,1QW5T@1224|Proteobacteria,2TWNW@28211|Alphaproteobacteria,36Y0Y@31993|Methylocystaceae	28211|Alphaproteobacteria	L	Transposase DDE domain	tnp*	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_548045_1	631362.Thi970DRAFT_02181	2.3e-81	258.0	COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,1RN5R@1236|Gammaproteobacteria,1WXRW@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
k59_495631_1	1038859.AXAU01000003_gene6186	1.23e-133	399.0	COG0577@1|root,COG1136@1|root,COG0577@2|Bacteria,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,2TS3W@28211|Alphaproteobacteria,3JTIG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	V	Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides	-	-	-	ko:K02003,ko:K05685	ko02010,map02010	M00258,M00709	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.122.1,3.A.1.122.12	-	-	ABC_tran,FtsX,MacB_PCD
k59_1604693_1	314285.KT71_03592	1.4e-54	179.0	COG1024@1|root,COG1024@2|Bacteria,1RAAV@1224|Proteobacteria,1SK2I@1236|Gammaproteobacteria,1J9RM@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
k59_717464_2	1459636.NTE_03505	4.8e-46	160.0	COG0475@1|root,arCOG01953@2157|Archaea,41T00@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Sodium hydrogen exchanger	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
k59_1162012_1	861299.J421_3563	6.02e-83	268.0	COG0317@1|root,COG0317@2|Bacteria,1ZT5M@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	-	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
k59_1328929_1	225937.HP15_3777	2.05e-46	155.0	COG1999@1|root,COG1999@2|Bacteria,1N6R6@1224|Proteobacteria,1SC88@1236|Gammaproteobacteria,46868@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	signal sequence binding	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1328929_2	351348.Maqu_0067	2.53e-24	98.2	COG3346@1|root,COG3346@2|Bacteria,1MZUH@1224|Proteobacteria,1S8S0@1236|Gammaproteobacteria,4684Q@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	SURF1-like protein	surf1	-	-	ko:K14998	-	-	-	-	ko00000,ko03029	3.D.4.8	-	-	SURF1
k59_1658990_2	420662.Mpe_A1223	2.02e-30	112.0	2B4XH@1|root,31XQC@2|Bacteria,1RHJF@1224|Proteobacteria,2W1BJ@28216|Betaproteobacteria,1KNAC@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1494989_1	1144275.COCOR_06701	2.09e-64	210.0	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,42MKS@68525|delta/epsilon subdivisions,2WKIH@28221|Deltaproteobacteria,2YYWU@29|Myxococcales	28221|Deltaproteobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_268294_1	1304875.JAFZ01000001_gene1136	1.21e-36	137.0	COG1217@1|root,COG1217@2|Bacteria,3T9TF@508458|Synergistetes	508458|Synergistetes	T	GTP-binding protein TypA	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
k59_1659006_1	1449065.JMLL01000018_gene1904	5.9e-70	221.0	COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,2TTNS@28211|Alphaproteobacteria,43GWY@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
k59_1659006_2	1207063.P24_11727	1.05e-16	78.6	COG1565@1|root,COG1565@2|Bacteria,1N3CJ@1224|Proteobacteria,2TRHW@28211|Alphaproteobacteria,2JPV6@204441|Rhodospirillales	204441|Rhodospirillales	S	Putative S-adenosyl-L-methionine-dependent methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_28
k59_327900_1	247490.KSU1_C0282	6.42e-43	163.0	COG3829@1|root,COG4191@1|root,COG3829@2|Bacteria,COG4191@2|Bacteria,2J2QC@203682|Planctomycetes	203682|Planctomycetes	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4
k59_656960_1	428125.CLOLEP_00746	1.37e-68	230.0	COG0209@1|root,COG0209@2|Bacteria,1TPFH@1239|Firmicutes,249EN@186801|Clostridia,3WGZ6@541000|Ruminococcaceae	186801|Clostridia	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdJ	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Intein_splicing,LAGLIDADG_3,Ribonuc_red_2_N,Ribonuc_red_lgC,Ribonuc_red_lgN,TSCPD
k59_826174_1	511.JT27_19810	4.49e-08	55.1	COG0454@1|root,COG0456@2|Bacteria,1RCYQ@1224|Proteobacteria,2WGJZ@28216|Betaproteobacteria,3T941@506|Alcaligenaceae	28216|Betaproteobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_826174_2	1173024.KI912151_gene1650	4.24e-19	88.2	COG1529@1|root,COG2080@1|root,COG1529@2|Bacteria,COG2080@2|Bacteria,1G35M@1117|Cyanobacteria,1JKA1@1189|Stigonemataceae	1117|Cyanobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2
k59_46880_1	243090.RB4846	2.76e-36	140.0	COG2864@1|root,COG2864@2|Bacteria	2|Bacteria	C	formate dehydrogenase	-	-	-	ko:K03620	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	Cytochrom_c3_2,Cytochrome_C554,Ni_hydr_CYTB
k59_212139_1	1236902.ANAS01000031_gene2783	2.85e-25	110.0	COG0654@1|root,COG0654@2|Bacteria,2I2TH@201174|Actinobacteria,4EJRD@85012|Streptosporangiales	201174|Actinobacteria	CH	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
k59_382057_1	1396141.BATP01000040_gene2167	1.36e-62	214.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,46TRH@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Tricorn protease PDZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
k59_1274419_1	1121406.JAEX01000001_gene321	1.45e-89	272.0	COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,42N17@68525|delta/epsilon subdivisions,2WJE8@28221|Deltaproteobacteria,2M85A@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	Belongs to the ALAD family	hemB	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
k59_1495092_1	1071679.BG57_09285	3.3e-60	198.0	COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,2VI13@28216|Betaproteobacteria,1K0VA@119060|Burkholderiaceae	28216|Betaproteobacteria	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	cheB	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
k59_1274429_1	1123368.AUIS01000007_gene2749	2.37e-78	260.0	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,1RMRN@1236|Gammaproteobacteria,2NBUJ@225057|Acidithiobacillales	225057|Acidithiobacillales	F	Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS_C,GATase_5
k59_994472_1	926569.ANT_25410	6.92e-95	293.0	COG0504@1|root,COG0504@2|Bacteria,2G5U0@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
k59_1329063_1	438753.AZC_1603	8.73e-50	175.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,2TT58@28211|Alphaproteobacteria,3EXWP@335928|Xanthobacteraceae	28211|Alphaproteobacteria	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	-	-	-	-	-	-	-	-	-	-	Carb_kinase,YjeF_N
k59_826209_1	1379270.AUXF01000001_gene1902	1.3e-26	113.0	COG4447@1|root,COG4447@2|Bacteria,1ZT1T@142182|Gemmatimonadetes	2|Bacteria	S	Sortilin, neurotensin receptor 3,	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
k59_1495100_1	639283.Snov_2771	1.85e-63	205.0	COG1703@1|root,COG1703@2|Bacteria,1MVI0@1224|Proteobacteria,2TS96@28211|Alphaproteobacteria,3F0BW@335928|Xanthobacteraceae	28211|Alphaproteobacteria	E	TIGRFAM LAO AO transport system ATPase	-	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
k59_1329069_1	518766.Rmar_1967	2.09e-26	105.0	COG1091@1|root,COG1091@2|Bacteria,4NE3K@976|Bacteroidetes,1FITS@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	M	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose	rfbD	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
k59_1604822_1	497964.CfE428DRAFT_0868	5.11e-44	150.0	COG2808@1|root,COG2808@2|Bacteria	2|Bacteria	K	Putative FMN-binding domain	paiB	-	-	ko:K07734	-	-	-	-	ko00000,ko03000	-	-	-	FMN_bind_2
k59_994486_1	448385.sce0411	5.85e-101	326.0	COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,42NAW@68525|delta/epsilon subdivisions,2WISU@28221|Deltaproteobacteria,2YUJI@29|Myxococcales	28221|Deltaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_1383611_1	398767.Glov_2401	7.15e-46	161.0	COG1775@1|root,COG1775@2|Bacteria,1NNW9@1224|Proteobacteria,42RTN@68525|delta/epsilon subdivisions,2WNYI@28221|Deltaproteobacteria,43V0Q@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	2-hydroxyglutaryl-CoA dehydratase, D-component	-	-	1.3.7.8	ko:K04112	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R02451	RC00002,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	HGD-D
k59_1770408_2	1278073.MYSTI_04455	3.33e-12	66.6	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,42N8U@68525|delta/epsilon subdivisions,2WJAN@28221|Deltaproteobacteria,2YYIW@29|Myxococcales	28221|Deltaproteobacteria	H	Belongs to the citrate synthase family	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
k59_382104_1	1229780.BN381_290116	3.63e-82	251.0	COG0189@1|root,COG0189@2|Bacteria,2HXBM@201174|Actinobacteria,3UX4W@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	F	Belongs to the RimK family	rimK	-	6.3.2.43	ko:K05827,ko:K05844	ko00300,ko01100,ko01210,ko01230,map00300,map01100,map01210,map01230	M00031	R09775	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000,ko03009	-	-	-	RimK,TrkA_C
k59_1383627_2	331869.BAL199_25224	1.25e-55	193.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2TQK9@28211|Alphaproteobacteria,4BP8W@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_1547187_1	1120959.ATXF01000007_gene2169	4.29e-27	114.0	2CA6S@1|root,2Z9P6@2|Bacteria,2IAT3@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_495797_1	670292.JH26_00425	1.04e-76	237.0	COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,1JTSW@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve,rve_3
k59_1437933_1	1384056.N787_01665	7.01e-36	135.0	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,1RPB4@1236|Gammaproteobacteria,1X64I@135614|Xanthomonadales	135614|Xanthomonadales	V	ABC-2 family transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_3
k59_1770429_1	926569.ANT_15280	1.61e-51	167.0	COG0669@1|root,COG0669@2|Bacteria,2G6NZ@200795|Chloroflexi	200795|Chloroflexi	F	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
k59_1770429_2	926569.ANT_15270	4.91e-19	86.7	COG1200@1|root,COG1200@2|Bacteria,2G5YM@200795|Chloroflexi	200795|Chloroflexi	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
k59_382133_1	1248916.ANFY01000003_gene498	7.44e-38	143.0	COG4805@1|root,COG4805@2|Bacteria,1R4HM@1224|Proteobacteria,2TTG9@28211|Alphaproteobacteria,2K3EP@204457|Sphingomonadales	204457|Sphingomonadales	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
k59_270263_1	864051.BurJ1DRAFT_2130	5.99e-58	192.0	COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,2VHPW@28216|Betaproteobacteria,1KJAV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	TIGRFAM chromate transporter, chromate ion transporter (CHR) family	-	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
k59_270263_2	1488328.JMCL01000083_gene1256	7.93e-14	67.8	COG4275@1|root,COG4275@2|Bacteria,1MYDE@1224|Proteobacteria	1224|Proteobacteria	P	Chromate resistance exported protein	-	-	-	-	-	-	-	-	-	-	-	-	Chrome_Resist,Rhodanese
k59_828453_1	1380394.JADL01000012_gene845	2.88e-57	185.0	COG2513@1|root,COG2513@2|Bacteria,1N4VT@1224|Proteobacteria,2TUUN@28211|Alphaproteobacteria,2JW6Z@204441|Rhodospirillales	204441|Rhodospirillales	G	Phosphoenolpyruvate phosphomutase	-	-	-	-	-	-	-	-	-	-	-	-	PEP_mutase
k59_828453_2	1549858.MC45_03600	2.98e-07	53.9	COG3568@1|root,COG3568@2|Bacteria,1MVN7@1224|Proteobacteria,2U1MH@28211|Alphaproteobacteria,2K0EG@204457|Sphingomonadales	204457|Sphingomonadales	L	endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
k59_1386234_1	861299.J421_0327	5.37e-16	75.9	COG4117@1|root,COG4117@2|Bacteria,1ZUUH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Prokaryotic cytochrome b561	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
k59_270280_1	1410665.JNKR01000001_gene476	2.62e-20	89.4	COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,4H22T@909932|Negativicutes	909932|Negativicutes	V	Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides	macB	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_996241_1	1123229.AUBC01000018_gene3708	1.05e-18	85.1	COG0134@1|root,COG0134@2|Bacteria,1MW5K@1224|Proteobacteria,2TSZE@28211|Alphaproteobacteria,3JQR7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Belongs to the TrpC family	trpC	GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831	4.1.1.48,5.3.1.24	ko:K01609,ko:K13498	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508,R03509	RC00944,RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
k59_1107296_1	926569.ANT_06750	2.57e-71	228.0	COG1207@1|root,COG1207@2|Bacteria,2G7KV@200795|Chloroflexi	200795|Chloroflexi	M	Hexapeptide repeat of succinyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
k59_884931_1	215803.DB30_0568	1.16e-09	64.3	COG0515@1|root,COG2319@1|root,COG0515@2|Bacteria,COG2319@2|Bacteria,1MWJA@1224|Proteobacteria,42P8D@68525|delta/epsilon subdivisions,2WMH1@28221|Deltaproteobacteria,2YWWP@29|Myxococcales	28221|Deltaproteobacteria	KLT	COG0515 Serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Pkinase,Pkinase_Tyr,WD40
k59_771624_1	631454.N177_1013	1.11e-152	446.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,2TTSQ@28211|Alphaproteobacteria,1JP5H@119043|Rhodobiaceae	28211|Alphaproteobacteria	H	3-octaprenyl-4-hydroxybenzoate carboxy-lyase	-	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
k59_884951_2	58123.JOFJ01000009_gene951	9.24e-19	89.0	COG0628@1|root,COG0628@2|Bacteria,2GN4Y@201174|Actinobacteria,4EFTZ@85012|Streptosporangiales	201174|Actinobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
k59_1718841_1	573569.F7308_1871	8.41e-21	95.9	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,1RNN0@1236|Gammaproteobacteria,45ZUP@72273|Thiotrichales	72273|Thiotrichales	E	Aminotransferase	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_49201_1	1034769.KB910518_gene1861	3.89e-48	171.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,4HA3S@91061|Bacilli,26S8D@186822|Paenibacillaceae	91061|Bacilli	V	ABC transporter	yheH	GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015399,GO:0015405,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0071702	-	ko:K18217,ko:K18890	ko02010,map02010	M00635,M00707	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	3.A.1,3.A.1.106.13,3.A.1.106.5	-	-	ABC_membrane,ABC_tran
k59_1386292_1	450851.PHZ_c3111	1.9e-14	76.6	COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,2TSGT@28211|Alphaproteobacteria,2KFAE@204458|Caulobacterales	28211|Alphaproteobacteria	E	acetylornithine	rocD	GO:0003674,GO:0005488,GO:0005515,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363	2.6.1.11,2.6.1.13,2.6.1.17	ko:K00819,ko:K00821	ko00220,ko00300,ko00330,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map00330,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R00667,R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_1164516_1	1267535.KB906767_gene751	4.88e-33	135.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_439237_2	1122134.KB893651_gene2268	2.48e-68	210.0	COG0717@1|root,COG0717@2|Bacteria,1MV2J@1224|Proteobacteria,1RMCD@1236|Gammaproteobacteria,1XI80@135619|Oceanospirillales	135619|Oceanospirillales	F	Belongs to the dCTP deaminase family	dcd	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	dUTPase
k59_1718879_1	1226325.HMPREF1548_05499	9.43e-65	212.0	COG3934@1|root,COG3934@2|Bacteria,1URPF@1239|Firmicutes,24XI3@186801|Clostridia	186801|Clostridia	G	Cellulase (glycosyl hydrolase family 5)	-	-	-	-	-	-	-	-	-	-	-	-	Cellulase
k59_1277243_1	1380355.JNIJ01000026_gene1348	1.44e-90	271.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,3K066@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110
k59_1107381_1	1123024.AUII01000025_gene2111	1.04e-100	303.0	COG1125@1|root,COG1125@2|Bacteria,2GJHI@201174|Actinobacteria,4DY7Y@85010|Pseudonocardiales	201174|Actinobacteria	E	glycine betaine	-	-	-	ko:K05847	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	ABC_tran,CBS
k59_105614_1	1124780.ANNU01000072_gene1068	5.8e-13	73.9	COG2866@1|root,COG2866@2|Bacteria,4NEJA@976|Bacteroidetes,47KZ0@768503|Cytophagia	976|Bacteroidetes	E	PFAM Zinc carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
k59_1440275_1	926569.ANT_06460	1.75e-96	294.0	COG1083@1|root,COG1778@1|root,COG1083@2|Bacteria,COG1778@2|Bacteria	2|Bacteria	S	3-deoxy-manno-octulosonate-8-phosphatase activity	neuA	-	2.7.7.43,3.1.3.45	ko:K00983,ko:K03270	ko00520,ko00540,ko01100,map00520,map00540,map01100	M00063	R01117,R03350,R04215	RC00017,RC00152	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_3,Hydrolase_3
k59_1164548_1	1541065.JRFE01000004_gene5325	2.31e-59	194.0	COG2207@1|root,COG2207@2|Bacteria,1G0B1@1117|Cyanobacteria	1117|Cyanobacteria	K	PFAM AraC-type transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AraC_N,HTH_18
k59_659307_1	113395.AXAI01000035_gene2	1.16e-35	138.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2TR49@28211|Alphaproteobacteria,3JRE0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Gamma-glutamyltranspeptidase	ggt	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006082,GO:0006508,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008242,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016787,GO:0019538,GO:0019752,GO:0030288,GO:0030313,GO:0031975,GO:0034722,GO:0036374,GO:0042597,GO:0043094,GO:0043102,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0070011,GO:0071704,GO:0097264,GO:0140096,GO:1901564,GO:1901566,GO:1901576	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k59_1497892_1	1313421.JHBV01000024_gene4946	9.78e-25	108.0	COG0612@1|root,COG0612@2|Bacteria,4NFY0@976|Bacteroidetes,1IP4P@117747|Sphingobacteriia	976|Bacteroidetes	S	Peptidase M16	pqqL	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_331010_1	1049564.TevJSym_bb00050	3.03e-24	102.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,1S0WV@1236|Gammaproteobacteria,1J5KF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases	korA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
k59_331010_2	665571.STHERM_c12570	7.08e-09	59.7	COG0493@1|root,COG0493@2|Bacteria,2J5FP@203691|Spirochaetes	203691|Spirochaetes	C	glutamate synthase (NADPH), homotetrameric	gltA	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2,Pyr_redox_3
k59_784298_2	379066.GAU_2710	4.44e-19	87.0	COG0296@1|root,COG0296@2|Bacteria,1ZT8Y@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
k59_339364_1	1267211.KI669560_gene2038	1.47e-09	64.7	COG0847@1|root,COG0847@2|Bacteria,4NE82@976|Bacteroidetes,1IPA8@117747|Sphingobacteriia	976|Bacteroidetes	L	DNA polymerase III	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
k59_228505_2	504728.K649_01740	1.28e-13	71.2	COG1250@1|root,COG1250@2|Bacteria,1WIN8@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	PFAM 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
k59_895761_1	1121378.KB899712_gene784	1.52e-27	105.0	COG2065@1|root,COG2065@2|Bacteria,1WJWR@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	F	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant	pyrR	-	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000,ko03000	-	-	-	Pribosyltran
k59_117068_1	1121878.AUGL01000026_gene1905	1.38e-33	134.0	COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,1RPV3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	NU	Tfp pilus assembly protein tip-associated adhesin PilY1	comC	-	-	ko:K02674	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Neisseria_PilC,VWA_2
k59_61688_1	330214.NIDE3406	2.07e-84	266.0	COG0129@1|root,COG0129@2|Bacteria,3J0ES@40117|Nitrospirae	40117|Nitrospirae	EG	Dehydratase family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
k59_1173492_1	1173263.Syn7502_03213	4.7e-103	314.0	COG2303@1|root,COG2303@2|Bacteria,1G2DQ@1117|Cyanobacteria,1GYJT@1129|Synechococcus	1117|Cyanobacteria	E	Dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
k59_1395898_1	1379270.AUXF01000002_gene1585	2.8e-81	265.0	COG0515@1|root,COG0515@2|Bacteria,1ZUMJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
k59_561799_1	177437.HRM2_20900	3.22e-64	218.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,42MPZ@68525|delta/epsilon subdivisions,2WIR9@28221|Deltaproteobacteria,2MHQG@213118|Desulfobacterales	28221|Deltaproteobacteria	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
k59_1618118_1	309801.trd_A0752	9.6e-90	279.0	COG0001@1|root,COG0001@2|Bacteria,2G67D@200795|Chloroflexi,27XJ3@189775|Thermomicrobia	189775|Thermomicrobia	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_839825_1	89187.ISM_05620	1.66e-69	225.0	COG0554@1|root,COG0554@2|Bacteria,1MUP7@1224|Proteobacteria,2TRD7@28211|Alphaproteobacteria,46NKE@74030|Roseovarius	28211|Alphaproteobacteria	H	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
k59_1340363_1	1429851.X548_12190	5.32e-66	208.0	COG2227@1|root,COG2227@2|Bacteria,1MU89@1224|Proteobacteria,1RMV7@1236|Gammaproteobacteria,1X4AM@135614|Xanthomonadales	135614|Xanthomonadales	H	O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway	ubiG	-	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_23
k59_1118268_1	1458357.BG58_13990	2.76e-84	258.0	COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,2VH4G@28216|Betaproteobacteria,1K00C@119060|Burkholderiaceae	28216|Betaproteobacteria	P	probably responsible for the translocation of the substrate across the membrane	pstC	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
k59_617520_1	1151116.Q7S_00555	3.82e-25	95.1	COG1942@1|root,COG1942@2|Bacteria,1N6WW@1224|Proteobacteria,1SC97@1236|Gammaproteobacteria,3FHSN@34037|Rahnella	1236|Gammaproteobacteria	G	4-oxalocrotonate tautomerase	dmpI	-	5.3.2.6	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	M00569	R03966,R05389	RC01040,RC01355	ko00000,ko00001,ko00002,ko01000	-	-	-	Tautomerase
k59_617520_2	1117318.PRUB_20434	1.62e-15	73.2	2DMPC@1|root,32SVH@2|Bacteria,1N06T@1224|Proteobacteria,1SA8W@1236|Gammaproteobacteria,2Q3NR@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	S	Putative lumazine-binding	-	-	-	-	-	-	-	-	-	-	-	-	Lumazine_bd_2
k59_839833_1	762903.Pedsa_2085	3.8e-38	141.0	COG0334@1|root,COG0334@2|Bacteria,4NF3I@976|Bacteroidetes,1IQ29@117747|Sphingobacteriia	976|Bacteroidetes	E	Belongs to the Glu Leu Phe Val dehydrogenases family	ldh	-	1.4.1.9	ko:K00263	ko00280,ko00290,ko01100,ko01110,ko01130,map00280,map00290,map01100,map01110,map01130	-	R01088,R01434,R02196	RC00006,RC00036	ko00000,ko00001,ko01000	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
k59_228581_1	991905.SL003B_0384	4.21e-10	63.9	COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2TRC2@28211|Alphaproteobacteria,4BP9X@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	I	Biotin carboxylase C-terminal domain	MA20_30205	-	6.4.1.4	ko:K01968	ko00280,ko01100,map00280,map01100	M00036	R04138	RC00367,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
k59_228581_2	1048339.KB913029_gene826	8.39e-21	86.3	COG2030@1|root,COG2030@2|Bacteria,2IK9K@201174|Actinobacteria,4EVCV@85013|Frankiales	201174|Actinobacteria	I	MaoC like domain	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
k59_561832_1	1151122.AQYD01000004_gene2600	5.43e-36	130.0	COG0428@1|root,COG0428@2|Bacteria,2GISJ@201174|Actinobacteria	201174|Actinobacteria	P	zinc transporter	-	-	-	ko:K07238	-	-	-	-	ko00000,ko02000	2.A.5.5	-	-	-
k59_561832_2	1283299.AUKG01000001_gene2762	2.88e-17	80.9	COG1960@1|root,COG1960@2|Bacteria,2GVSU@201174|Actinobacteria,4CPU5@84995|Rubrobacteria	84995|Rubrobacteria	I	Acyl-CoA dehydrogenase, middle domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_117134_1	114615.BRADO1325	2.42e-138	424.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,2TQZU@28211|Alphaproteobacteria,3JTPJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	F	Belongs to the CarB family	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_1507132_1	218851.Aquca_001_00394.1	7.44e-09	57.8	COG0678@1|root,KOG0541@2759|Eukaryota,37KHM@33090|Viridiplantae,3GDWK@35493|Streptophyta	35493|Streptophyta	O	peroxiredoxin activity	TPx1	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0009507,GO:0009536,GO:0010035,GO:0010038,GO:0016020,GO:0042221,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0046686,GO:0050896,GO:0071944	-	-	-	-	-	-	-	-	-	-	Redoxin
k59_1507132_2	1089552.KI911559_gene3712	9.59e-19	82.8	COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,2TTX4@28211|Alphaproteobacteria,2JSB3@204441|Rhodospirillales	204441|Rhodospirillales	K	Belongs to the UPF0301 (AlgH) family	-	-	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
k59_1451798_2	1057002.KB905370_gene4030	3.27e-112	329.0	COG4674@1|root,COG4674@2|Bacteria,1MUBR@1224|Proteobacteria,2TQVJ@28211|Alphaproteobacteria,4B8UN@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter, ATP-binding protein	urtD	-	-	ko:K11962	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	ABC_tran,BCA_ABC_TP_C
k59_339446_1	1123250.KB908395_gene1872	3.04e-33	125.0	COG0133@1|root,COG0133@2|Bacteria,1TPI3@1239|Firmicutes,4H2MH@909932|Negativicutes	909932|Negativicutes	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_339446_2	1382306.JNIM01000001_gene2652	4.83e-28	111.0	COG0159@1|root,COG0159@2|Bacteria,2G6AY@200795|Chloroflexi	200795|Chloroflexi	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
k59_1395947_1	765420.OSCT_1117	5.14e-11	64.3	COG5002@1|root,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS_4,Response_reg
k59_1395947_2	1492922.GY26_12500	2.29e-19	84.7	COG0163@1|root,COG0163@2|Bacteria,1RA0P@1224|Proteobacteria,1RPN1@1236|Gammaproteobacteria,1J5R4@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	ubiX	GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008694,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavoprotein
k59_784400_1	590998.Celf_0590	6.92e-73	227.0	COG0745@1|root,COG0745@2|Bacteria,2GKFS@201174|Actinobacteria,4F0T8@85016|Cellulomonadaceae	201174|Actinobacteria	T	Transcriptional regulatory protein, C terminal	regX3	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009405,GO:0009889,GO:0010468,GO:0010556,GO:0010565,GO:0019216,GO:0019217,GO:0019219,GO:0019220,GO:0019222,GO:0031323,GO:0031326,GO:0044419,GO:0048583,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051252,GO:0051704,GO:0060255,GO:0062012,GO:0065007,GO:0080090,GO:0080134,GO:0097159,GO:1901363,GO:1902882,GO:1903506,GO:2000112,GO:2001141	-	ko:K07776	ko02020,map02020	M00443	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_1673956_2	471852.Tcur_4795	5.02e-15	73.6	COG0637@1|root,COG0637@2|Bacteria	2|Bacteria	S	phosphonoacetaldehyde hydrolase activity	-	-	5.4.2.6	ko:K01838	ko00500,map00500	-	R02728,R11310	RC00408	ko00000,ko00001,ko01000	-	-	-	HAD_2,Hydrolase
k59_117152_1	1094508.Tsac_2010	1.34e-130	382.0	COG0133@1|root,COG0133@2|Bacteria,1TPI3@1239|Firmicutes,24881@186801|Clostridia,42EWK@68295|Thermoanaerobacterales	186801|Clostridia	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_1284789_1	1379270.AUXF01000004_gene3070	8.65e-61	196.0	COG1194@1|root,COG1194@2|Bacteria,1ZTNM@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	FES	-	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
k59_61765_1	1121918.ARWE01000001_gene3016	2.78e-77	246.0	COG0189@1|root,COG0189@2|Bacteria,1MX5X@1224|Proteobacteria,42MPG@68525|delta/epsilon subdivisions,2WKW8@28221|Deltaproteobacteria,43UK8@69541|Desulfuromonadales	28221|Deltaproteobacteria	HJ	RimK-like ATPgrasp N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Dala_Dala_lig_C,RLAN,RimK
k59_951333_1	1304865.JAGF01000001_gene3755	2.07e-48	164.0	COG0842@1|root,COG0842@2|Bacteria,2GMXR@201174|Actinobacteria	201174|Actinobacteria	V	transport, permease protein	-	-	-	ko:K09694	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC2_membrane
k59_951333_2	1304865.JAGF01000001_gene3756	0.000144	45.4	COG0842@1|root,COG0842@2|Bacteria,2GVC2@201174|Actinobacteria	201174|Actinobacteria	V	transport, permease protein	-	-	-	ko:K09694	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC2_membrane
k59_395295_1	864051.BurJ1DRAFT_4676	1.76e-93	290.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,1KN8W@119065|unclassified Burkholderiales	28216|Betaproteobacteria	NU	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB	-	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
k59_6356_1	670292.JH26_11550	0.000203	43.9	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,1JSYN@119045|Methylobacteriaceae	28211|Alphaproteobacteria	T	PFAM Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,Guanylate_cyc,TPR_14,TPR_16
k59_6356_2	261292.Nit79A3_0138	1.29e-113	335.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1MW7X@1224|Proteobacteria,2VMDX@28216|Betaproteobacteria	28216|Betaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_23,HTH_32
k59_507956_1	91464.S7335_963	1.1e-49	179.0	COG2909@1|root,COG2909@2|Bacteria,1G3UH@1117|Cyanobacteria	1117|Cyanobacteria	K	ATP-dependent transcriptional regulator	-	-	-	ko:K03556	-	-	-	-	ko00000,ko03000	-	-	-	GerE
k59_1008460_1	530564.Psta_3595	1.42e-37	144.0	COG1716@1|root,COG2203@1|root,COG2204@1|root,COG1716@2|Bacteria,COG2203@2|Bacteria,COG2204@2|Bacteria,2IY6A@203682|Planctomycetes	203682|Planctomycetes	T	Ornithine decarboxylase inhibitor-putative sigma54 transciptional regulator	-	-	-	ko:K02584	ko02020,map02020	-	-	-	ko00000,ko00001,ko03000	-	-	-	FHA,GAF,GAF_2,HTH_8,Sigma54_activat
k59_1008460_2	234267.Acid_1140	6.09e-05	44.7	COG4980@1|root,COG4980@2|Bacteria,3Y8W2@57723|Acidobacteria	57723|Acidobacteria	S	YtxH-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YtxH
k59_1730936_1	935948.KE386494_gene408	4.03e-29	118.0	COG0793@1|root,COG0793@2|Bacteria,1TPBI@1239|Firmicutes,248HZ@186801|Clostridia,42EZ3@68295|Thermoanaerobacterales	186801|Clostridia	M	Belongs to the peptidase S41A family	ctpA	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
k59_897394_1	1340493.JNIF01000003_gene2642	9.19e-49	183.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_1175054_1	1248916.ANFY01000004_gene1771	3.02e-63	213.0	COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TQMV@28211|Alphaproteobacteria,2KD4R@204457|Sphingomonadales	204457|Sphingomonadales	G	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ,PQQ_2
k59_118561_1	195250.CM001776_gene1050	1.33e-14	78.6	COG0668@1|root,COG0668@2|Bacteria,1G0ZM@1117|Cyanobacteria,1GZD1@1129|Synechococcus	1117|Cyanobacteria	M	Conserved TM helix	-	-	-	-	-	-	-	-	-	-	-	-	TM_helix
k59_563349_1	379066.GAU_2518	1.13e-70	227.0	COG4972@1|root,COG4972@2|Bacteria,1ZSYA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	NU	Type IV pilus assembly protein PilM;	-	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
k59_1008500_1	316279.Syncc9902_1301	1.33e-35	139.0	COG0587@1|root,COG0587@2|Bacteria,1G0US@1117|Cyanobacteria,1GZ5J@1129|Synechococcus	1117|Cyanobacteria	L	DNA polymerase	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_340979_1	1459636.NTE_00636	1.59e-68	218.0	COG0524@1|root,arCOG00014@2157|Archaea,41SX4@651137|Thaumarchaeota	651137|Thaumarchaeota	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
k59_1619637_1	1294273.roselon_02951	1.28e-45	155.0	2AFPW@1|root,32Z6T@2|Bacteria,1NC9H@1224|Proteobacteria,2UIAS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_230189_2	448385.sce7755	5.01e-16	79.3	COG3845@1|root,COG3845@2|Bacteria,1NT0H@1224|Proteobacteria,42NTY@68525|delta/epsilon subdivisions,2WK4F@28221|Deltaproteobacteria,2YUKQ@29|Myxococcales	28221|Deltaproteobacteria	S	ABC transporter	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
k59_841328_1	1247963.JPHU01000012_gene933	1.01e-73	231.0	COG1680@1|root,COG1680@2|Bacteria,1NHIY@1224|Proteobacteria,2U0A3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	Beta-lactamase class C and other penicillin binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_1119906_1	671143.DAMO_2769	1.33e-142	420.0	COG0443@1|root,COG0443@2|Bacteria,2NNU1@2323|unclassified Bacteria	2|Bacteria	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
k59_285734_1	1382306.JNIM01000001_gene1878	1.99e-25	110.0	COG0060@1|root,COG0060@2|Bacteria,2G5SN@200795|Chloroflexi	200795|Chloroflexi	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	-	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
k59_1008522_1	861299.J421_1167	1.1e-66	213.0	COG1475@1|root,COG1475@2|Bacteria,1ZSKT@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	ParB-like nuclease domain	-	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
k59_63240_1	234267.Acid_7630	1.79e-61	202.0	COG3335@1|root,COG3335@2|Bacteria	2|Bacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
k59_230205_2	1121364.ATVG01000002_gene1333	2.33e-11	66.2	COG1595@1|root,COG1595@2|Bacteria,2GK4C@201174|Actinobacteria,22KGP@1653|Corynebacteriaceae	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	sigE	GO:0000302,GO:0000988,GO:0000990,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009405,GO:0009408,GO:0009410,GO:0009605,GO:0009607,GO:0009628,GO:0009636,GO:0009889,GO:0010035,GO:0010468,GO:0010556,GO:0016987,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0040007,GO:0042221,GO:0042493,GO:0042542,GO:0043207,GO:0043254,GO:0044087,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0060255,GO:0065007,GO:0075136,GO:0080090,GO:0090034,GO:0097159,GO:0140110,GO:1901363,GO:1901700,GO:1903506,GO:2000112,GO:2000142,GO:2001141	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_952655_1	518766.Rmar_2576	1.66e-31	120.0	COG0446@1|root,COG0446@2|Bacteria,4NEK6@976|Bacteroidetes,1FJZ5@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_675025_2	941449.dsx2_1572	5.81e-07	55.1	COG0500@1|root,COG2226@2|Bacteria,1N73D@1224|Proteobacteria,42XDU@68525|delta/epsilon subdivisions,2WTBP@28221|Deltaproteobacteria,2MBEV@213115|Desulfovibrionales	28221|Deltaproteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_508044_1	1461693.ATO10_13019	1.67e-90	281.0	COG0747@1|root,COG0747@2|Bacteria,1MWR7@1224|Proteobacteria,2TS51@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	ABC-type dipeptide transport system periplasmic component	MA20_22710	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5,TAT_signal
k59_841369_1	1323663.AROI01000006_gene2833	1.4e-76	239.0	COG1840@1|root,COG1840@2|Bacteria,1MUEG@1224|Proteobacteria,1RQ6Z@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	ABC-type Fe3 transport system, periplasmic component	fbpA	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
k59_730713_1	525904.Tter_1452	8.1e-35	132.0	COG0303@1|root,COG0303@2|Bacteria,2NP4N@2323|unclassified Bacteria	2|Bacteria	H	MoeA N-terminal region (domain I and II)	moeA	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
k59_1231636_1	1196031.ALEG01000046_gene4509	1.38e-77	241.0	COG2043@1|root,COG2043@2|Bacteria,1TT5P@1239|Firmicutes,4HFED@91061|Bacilli,1ZAXA@1386|Bacillus	91061|Bacilli	S	Uncharacterised ArCR, COG2043	-	-	-	-	-	-	-	-	-	-	-	-	DUF169
k59_841379_1	485913.Krac_5027	1.23e-20	96.3	COG2909@1|root,COG3903@1|root,COG2909@2|Bacteria,COG3903@2|Bacteria,2G7SC@200795|Chloroflexi	200795|Chloroflexi	K	intracellular signal transduction	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,TPR_12
k59_563408_1	1430440.MGMSRv2_3547	1.45e-37	133.0	COG2214@1|root,COG2214@2|Bacteria,1RBI0@1224|Proteobacteria,2U6JH@28211|Alphaproteobacteria,2JSG4@204441|Rhodospirillales	204441|Rhodospirillales	O	DnaJ-class molecular chaperone	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_563408_2	323097.Nham_0073	2.42e-19	87.4	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1MWKS@1224|Proteobacteria,2TQV8@28211|Alphaproteobacteria,3JUGP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
k59_630391_2	219305.MCAG_04237	1.93e-06	52.0	COG0454@1|root,COG0456@2|Bacteria,2IFF2@201174|Actinobacteria,4DD0M@85008|Micromonosporales	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_1353942_1	1178825.ALIH01000010_gene398	6.55e-05	47.8	COG0457@1|root,COG0457@2|Bacteria,4NFIY@976|Bacteroidetes,1HYA6@117743|Flavobacteriia	976|Bacteroidetes	S	PFAM Peptidase family M49	-	-	3.4.14.4	ko:K01277	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M49
k59_1353942_2	1379270.AUXF01000001_gene2139	5.19e-15	75.9	COG1228@1|root,COG1228@2|Bacteria,1ZSU7@142182|Gemmatimonadetes	142182|Gemmatimonadetes	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_130117_1	1207063.P24_05204	5.49e-35	129.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,2TTGJ@28211|Alphaproteobacteria,2JQ2F@204441|Rhodospirillales	204441|Rhodospirillales	E	Aspartate tyrosine aromatic aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
k59_1687503_1	1238182.C882_0847	5.63e-18	83.2	COG4122@1|root,COG4122@2|Bacteria,1RB34@1224|Proteobacteria,2VGIH@28211|Alphaproteobacteria,2JS0H@204441|Rhodospirillales	204441|Rhodospirillales	S	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_3
k59_1132151_1	1382306.JNIM01000001_gene766	6.38e-20	93.6	COG0166@1|root,COG0166@2|Bacteria,2G67J@200795|Chloroflexi	200795|Chloroflexi	G	Belongs to the GPI family	pgi	-	2.2.1.2,5.3.1.9	ko:K01810,ko:K13810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00004,M00007,M00114	R01827,R02739,R02740,R03321	RC00376,RC00439,RC00563,RC00604	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI,TAL_FSA
k59_1631017_2	243365.CV_2102	1.61e-08	54.3	COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,2VIS0@28216|Betaproteobacteria,2KQ7J@206351|Neisseriales	206351|Neisseriales	S	Peptidase dimerisation domain	-	-	3.5.1.32	ko:K01451	ko00360,map00360	-	R01424	RC00096,RC00162	ko00000,ko00001,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
k59_1187050_1	2074.JNYD01000007_gene2172	2.54e-25	102.0	2ADQJ@1|root,313FX@2|Bacteria,2H0DG@201174|Actinobacteria,4E2J8@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_408886_1	1120956.JHZK01000004_gene1469	4.92e-93	294.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2TS8E@28211|Alphaproteobacteria,1JNC8@119043|Rhodobiaceae	28211|Alphaproteobacteria	I	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain	fadJ	-	1.1.1.35,4.2.1.17,5.1.2.3	ko:K01782	ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
k59_297668_1	981384.AEYW01000001_gene1535	1.14e-18	84.3	COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,2TTPH@28211|Alphaproteobacteria,4NCXC@97050|Ruegeria	28211|Alphaproteobacteria	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
k59_798194_1	1220535.IMCC14465_17900	6.59e-19	90.9	COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,2TRC1@28211|Alphaproteobacteria,4BPMP@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	GO:0000175,GO:0003674,GO:0003724,GO:0003824,GO:0004386,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008408,GO:0008997,GO:0009056,GO:0009057,GO:0009266,GO:0009409,GO:0009628,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016788,GO:0016796,GO:0016817,GO:0016818,GO:0016896,GO:0017111,GO:0019222,GO:0019439,GO:0034458,GO:0034470,GO:0034641,GO:0034655,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:1901360,GO:1901361,GO:1901575	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	RNB,S1
k59_19830_1	497321.C664_15358	3.25e-42	152.0	COG2706@1|root,COG2706@2|Bacteria,1MWGS@1224|Proteobacteria,2VKJU@28216|Betaproteobacteria,2KYCT@206389|Rhodocyclales	206389|Rhodocyclales	G	Lactonase, 7-bladed beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
k59_1075802_1	378753.KRH_10030	1.52e-31	119.0	COG0127@1|root,COG0127@2|Bacteria,2GM2B@201174|Actinobacteria,1W7MW@1268|Micrococcaceae	201174|Actinobacteria	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	rdgB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
k59_297686_1	768704.Desmer_2359	1.1e-12	74.3	COG0642@1|root,COG2202@1|root,COG4191@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,COG4191@2|Bacteria,1TQ8G@1239|Firmicutes,24IMT@186801|Clostridia,2651V@186807|Peptococcaceae	186801|Clostridia	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_9
k59_352606_1	1205908.AKXW01000004_gene3110	1.34e-40	146.0	COG5361@1|root,COG5361@2|Bacteria,1NBVB@1224|Proteobacteria,1SES6@1236|Gammaproteobacteria,1Y1IS@135623|Vibrionales	135623|Vibrionales	S	Neurotransmitter-gated ion-channel ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Neur_chan_LBD
k59_1132200_1	1197130.BAFM01000001_gene230	7.61e-12	66.2	COG1917@1|root,arCOG02994@2157|Archaea,2Y07C@28890|Euryarchaeota,23Y8S@183963|Halobacteria	183963|Halobacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_408929_1	561175.KB894094_gene1750	5e-15	79.7	COG2141@1|root,COG2141@2|Bacteria,2GKP1@201174|Actinobacteria,4EHH5@85012|Streptosporangiales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_465293_1	251221.35212044	1.83e-33	134.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_1075849_1	1122226.AUHX01000001_gene867	5.73e-30	123.0	COG1452@1|root,COG1452@2|Bacteria,4NFWD@976|Bacteroidetes,1HXS2@117743|Flavobacteriia	976|Bacteroidetes	M	Organic solvent tolerance protein OstA	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_964972_1	309801.trd_0160	1.43e-34	119.0	COG0425@1|root,COG0425@2|Bacteria,2G7DF@200795|Chloroflexi	200795|Chloroflexi	O	Belongs to the sulfur carrier protein TusA family	-	-	-	-	-	-	-	-	-	-	-	-	TusA
k59_964972_2	309801.trd_0159	1.68e-22	91.3	COG2210@1|root,COG2210@2|Bacteria,2G77F@200795|Chloroflexi	200795|Chloroflexi	S	DsrE/DsrF/DrsH-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2
k59_19882_1	1168059.KB899087_gene1279	3.14e-20	92.8	COG0154@1|root,COG0154@2|Bacteria,1MWRI@1224|Proteobacteria,2TTJU@28211|Alphaproteobacteria,3F11J@335928|Xanthobacteraceae	28211|Alphaproteobacteria	J	Amidase	-	-	-	-	-	-	-	-	-	-	-	-	Amidase
k59_242077_1	396588.Tgr7_2027	5.25e-64	197.0	COG0780@1|root,COG0780@2|Bacteria,1MW0M@1224|Proteobacteria,1TJD2@1236|Gammaproteobacteria,1WYEP@135613|Chromatiales	135613|Chromatiales	S	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)	queF	-	1.7.1.13	ko:K09457	ko00790,ko01100,map00790,map01100	-	R07605	RC01875	ko00000,ko00001,ko01000,ko03016	-	-	-	QueF
k59_242077_2	557598.LHK_02880	2.54e-17	80.5	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,2VJMF@28216|Betaproteobacteria,2KPDU@206351|Neisseriales	206351|Neisseriales	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
k59_910226_1	926554.KI912636_gene3108	0.000213	48.9	COG2885@1|root,COG4886@1|root,COG4932@1|root,COG2885@2|Bacteria,COG4886@2|Bacteria,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	-	ko:K16191,ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001,ko02000	1.B.6.1.3	-	-	Big_1,Flg_new,LRR_5,Mfa_like_1,RCC1
k59_352639_1	452863.Achl_3753	5.13e-85	261.0	2C1EG@1|root,2Z7MZ@2|Bacteria,2GK4W@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_352639_2	1150864.MILUP08_44194	0.000504	43.1	COG1247@1|root,COG1247@2|Bacteria,2I3CR@201174|Actinobacteria,4DDTD@85008|Micromonosporales	201174|Actinobacteria	M	GCN5 family acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_964980_1	880073.Calab_2588	3.66e-14	70.1	COG0217@1|root,COG0217@2|Bacteria,2NNSI@2323|unclassified Bacteria	2|Bacteria	K	Transcriptional regulatory protein	yebC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
k59_964980_2	398767.Glov_2678	8.67e-28	109.0	COG2876@1|root,COG2876@2|Bacteria,1QVAD@1224|Proteobacteria,42MU4@68525|delta/epsilon subdivisions,2WJ8Y@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM DAHP synthetase I KDSA	aroG-2	-	2.5.1.54,5.4.99.5	ko:K03856,ko:K04516	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022,M00024,M00025	R01715,R01826	RC00435,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_2,DAHP_synth_1
k59_1411453_1	472175.EL18_02738	2.6e-13	76.3	COG1866@1|root,COG1866@2|Bacteria,1MWXN@1224|Proteobacteria,2TRC4@28211|Alphaproteobacteria,43GSQ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA	pckA	GO:0003674,GO:0003824,GO:0004611,GO:0004612,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016829,GO:0016830,GO:0016831,GO:0019318,GO:0019319,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0071704,GO:1901576	4.1.1.49	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00170	R00341	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_ATP
k59_966830_1	400682.PAC_15704812	5.92e-30	119.0	COG0152@1|root,KOG2835@2759|Eukaryota	2759|Eukaryota	F	phosphoribosylaminoimidazole carboxylase activity	-	-	-	-	-	-	-	-	-	-	-	-	AIRC
k59_966830_2	396588.Tgr7_0360	1.29e-124	367.0	COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,1RNS4@1236|Gammaproteobacteria,1WW3A@135613|Chromatiales	135613|Chromatiales	F	Belongs to the GARS family	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
k59_76929_1	869213.JCM21142_72768	4.14e-19	87.4	COG3201@1|root,COG3201@2|Bacteria,4NFJI@976|Bacteroidetes,47R6S@768503|Cytophagia	976|Bacteroidetes	H	TIGRFAM Nicotinamide mononucleotide transporter PnuC	pnuC	-	-	ko:K03811	-	-	-	-	ko00000,ko02000	4.B.1.1	-	-	NMN_transporter
k59_1467175_1	1166018.FAES_3037	2.21e-14	78.2	COG0642@1|root,COG0745@1|root,COG2207@1|root,COG3292@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,COG2207@2|Bacteria,COG3292@2|Bacteria,4NDXU@976|Bacteroidetes,47JBS@768503|Cytophagia	976|Bacteroidetes	T	Two component regulator propeller	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y
k59_1411474_1	706587.Desti_0547	1.43e-97	297.0	COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,42M5D@68525|delta/epsilon subdivisions,2WJ59@28221|Deltaproteobacteria,2MQ8E@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
k59_1189002_1	1509405.GV67_09880	2.75e-21	97.4	COG2267@1|root,COG3629@1|root,COG2267@2|Bacteria,COG3629@2|Bacteria,1QU9N@1224|Proteobacteria,2TW44@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IT	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
k59_1134053_1	861299.J421_4450	3.27e-87	286.0	COG0466@1|root,COG0466@2|Bacteria,1ZTCH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_21697_1	118161.KB235922_gene2432	2.03e-36	140.0	COG3437@1|root,COG5002@1|root,COG3437@2|Bacteria,COG5002@2|Bacteria,1FZYQ@1117|Cyanobacteria,3VIWA@52604|Pleurocapsales	1117|Cyanobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
k59_689262_2	1485543.JMME01000001_gene1424	1.21e-06	51.6	COG0083@1|root,COG0083@2|Bacteria,1TRWS@1239|Firmicutes,4H272@909932|Negativicutes	909932|Negativicutes	E	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate	thrB	-	2.7.1.39	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
k59_1134087_1	365044.Pnap_1746	2.92e-19	92.4	COG3677@1|root,COG3677@2|Bacteria,1R999@1224|Proteobacteria	1224|Proteobacteria	L	Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1595,HTH_23,Zn_Tnp_IS1595
k59_744530_1	404589.Anae109_3003	4.69e-104	315.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,42MDU@68525|delta/epsilon subdivisions,2WM9V@28221|Deltaproteobacteria,2YUA7@29|Myxococcales	28221|Deltaproteobacteria	C	Aldehyde dehydrogenase family	gabD	-	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_354514_1	1231391.AMZF01000006_gene2762	3.97e-16	84.3	COG0007@1|root,COG1648@1|root,COG0007@2|Bacteria,COG1648@2|Bacteria,1MUI0@1224|Proteobacteria,2VICS@28216|Betaproteobacteria,3T1JA@506|Alcaligenaceae	28216|Betaproteobacteria	H	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme	cysG	-	1.3.1.76,2.1.1.107,4.99.1.4	ko:K02302,ko:K02303	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03194,R03947	RC00003,RC00871,RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	CysG_dimeriser,NAD_binding_7,Sirohm_synth_M,TP_methylase
k59_1300281_1	688245.CtCNB1_0219	2.19e-30	120.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VKW3@28216|Betaproteobacteria,4ABRG@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_912161_2	1255043.TVNIR_3057	1.98e-44	155.0	COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria	1224|Proteobacteria	GM	Epimerase dehydratase	-	-	1.6.5.3,1.6.99.3	ko:K00329,ko:K00356	ko00190,map00190	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	3Beta_HSD,Epimerase,NAD_binding_10,RmlD_sub_bind
k59_966912_1	273116.14325522	9.9e-31	119.0	COG0183@1|root,arCOG01280@2157|Archaea,2Y85P@28890|Euryarchaeota,241YR@183967|Thermoplasmata	183967|Thermoplasmata	I	Thiolase, N-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_21747_1	883.DvMF_0767	4.1e-32	122.0	COG4974@1|root,COG4974@2|Bacteria,1QU6A@1224|Proteobacteria,42Q4U@68525|delta/epsilon subdivisions,2WJ08@28221|Deltaproteobacteria,2M93X@213115|Desulfovibrionales	28221|Deltaproteobacteria	D	Belongs to the 'phage' integrase family. XerC subfamily	xerC	-	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_744555_1	381666.H16_B0948	2.13e-50	178.0	COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,2VIEA@28216|Betaproteobacteria,1KFF9@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family	nirB	-	1.18.1.1,1.7.1.15	ko:K00362,ko:K05297	ko00071,ko00910,ko01120,map00071,map00910,map01120	M00530	R00787,R02000	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2
k59_410815_2	1306990.BARG01000159_gene10575	1.64e-07	56.6	COG1595@1|root,COG1595@2|Bacteria,2ID45@201174|Actinobacteria	201174|Actinobacteria	K	Sigma-70 region 2	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_1134118_1	380394.Lferr_0119	7.05e-45	159.0	COG5433@1|root,COG5433@2|Bacteria,1RAHU@1224|Proteobacteria,1S1TZ@1236|Gammaproteobacteria,2NDWK@225057|Acidithiobacillales	1236|Gammaproteobacteria	L	DDE_Tnp_1-associated	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc,DUF4338
k59_1356142_1	1379270.AUXF01000006_gene150	2.91e-40	141.0	2DEWU@1|root,2ZPJP@2|Bacteria,1ZUFA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1356144_1	269799.Gmet_3052	9.87e-11	68.2	COG0265@1|root,COG0457@1|root,COG0265@2|Bacteria,COG0457@2|Bacteria,1NE6G@1224|Proteobacteria,4321S@68525|delta/epsilon subdivisions,2WWD7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Trypsin-like peptidase domain	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin_2
k59_912210_1	296591.Bpro_1646	4.11e-67	207.0	COG4319@1|root,COG4319@2|Bacteria,1NH3X@1224|Proteobacteria	1224|Proteobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440,SnoaL_3
k59_1522540_1	570967.JMLV01000009_gene1011	5.1e-115	349.0	COG4166@1|root,COG4166@2|Bacteria,1MUVU@1224|Proteobacteria,2TQJX@28211|Alphaproteobacteria,2JQ6J@204441|Rhodospirillales	204441|Rhodospirillales	E	COG4166 ABC-type oligopeptide transport system, periplasmic component	-	-	-	ko:K13893	ko02010,map02010	M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.21,3.A.1.5.24	-	-	SBP_bac_5
k59_188079_1	446462.Amir_6075	1.46e-89	285.0	COG0296@1|root,COG3170@1|root,COG0296@2|Bacteria,COG3170@2|Bacteria,2GJ5C@201174|Actinobacteria,4E0S6@85010|Pseudonocardiales	201174|Actinobacteria	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
k59_800185_1	1382304.JNIL01000001_gene2960	1.86e-67	230.0	COG0567@1|root,COG0567@2|Bacteria,1TRDW@1239|Firmicutes,4HAUI@91061|Bacilli,279I7@186823|Alicyclobacillaceae	91061|Bacilli	C	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3)	odhA	GO:0003674,GO:0003824,GO:0004591,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016624,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045333,GO:0055114,GO:0071704,GO:0072350,GO:1902494,GO:1990204,GO:1990234	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
k59_744590_1	316274.Haur_0037	9.59e-114	345.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,2G69H@200795|Chloroflexi,37507@32061|Chloroflexia	32061|Chloroflexia	C	pyruvate flavodoxin ferredoxin oxidoreductase domain protein	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
k59_632282_1	1125863.JAFN01000001_gene207	2.58e-95	286.0	COG1028@1|root,COG1028@2|Bacteria,1QXA0@1224|Proteobacteria,42UQH@68525|delta/epsilon subdivisions,2WQ5R@28221|Deltaproteobacteria	28221|Deltaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_1522549_2	1232410.KI421420_gene3171	9.01e-15	75.5	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria,43S1D@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC	ctpF	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
k59_467247_1	384765.SIAM614_22717	5.65e-134	394.0	COG3547@1|root,COG3547@2|Bacteria,1MW0N@1224|Proteobacteria,2TUGE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	PFAM transposase IS116 IS110 IS902 family	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1077804_1	2340.JV46_05690	4.92e-80	249.0	COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,1RN7B@1236|Gammaproteobacteria,1JBRQ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	L COG2826 Transposase and inactivated derivatives, IS30 family	insI	GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004803,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006310,GO:0006313,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0030983,GO:0032135,GO:0032196,GO:0032991,GO:0032993,GO:0034641,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363	-	ko:K07482	-	-	-	-	ko00000	-	-	-	HTH_38,rve
k59_689351_1	936375.HMPREF1152_1826	3.49e-25	107.0	COG2890@1|root,COG3872@1|root,COG2890@2|Bacteria,COG3872@2|Bacteria,1TPBU@1239|Firmicutes,25C8E@186801|Clostridia,3WD2N@538999|Clostridiales incertae sedis	186801|Clostridia	J	Protein of unknown function (DUF1385)	prmC	-	-	-	-	-	-	-	-	-	-	-	DUF1385,MTS
k59_299678_1	926569.ANT_03800	2.41e-25	103.0	COG0030@1|root,COG0030@2|Bacteria,2G6DA@200795|Chloroflexi	200795|Chloroflexi	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
k59_299678_2	926569.ANT_03790	4.92e-18	81.6	COG0463@1|root,COG0463@2|Bacteria,2GBP0@200795|Chloroflexi	200795|Chloroflexi	M	Glycosyltransferase like family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
k59_1522560_1	518766.Rmar_2597	1.48e-81	253.0	COG3345@1|root,COG3345@2|Bacteria,4NFSU@976|Bacteroidetes	976|Bacteroidetes	G	alpha-galactosidase	melA	-	3.2.1.22	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Melibiase_2,Melibiase_2_C
k59_314526_1	1123073.KB899241_gene2287	3.41e-39	143.0	COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,1RN2A@1236|Gammaproteobacteria,1X7MH@135614|Xanthomonadales	135614|Xanthomonadales	E	Glycine cleavage T-protein C-terminal barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	GCV_T,GCV_T_C
k59_645486_1	333138.LQ50_20095	1.59e-66	216.0	COG4638@1|root,COG4638@2|Bacteria,1UYZZ@1239|Firmicutes,4I68U@91061|Bacilli,1ZDPN@1386|Bacillus	91061|Bacilli	P	Rieske [2Fe-2S] domain	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
k59_200981_1	395494.Galf_1436	6e-80	258.0	COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,2VP2B@28216|Betaproteobacteria,44W71@713636|Nitrosomonadales	28216|Betaproteobacteria	P	ABC transporter transmembrane region	-	-	-	ko:K11004	ko02010,ko03070,ko05133,map02010,map03070,map05133	M00325,M00575	-	-	ko00000,ko00001,ko00002,ko02000,ko02044	3.A.1.109.1,3.A.1.109.2	-	-	ABC_membrane,ABC_tran
k59_927636_1	1211813.CAPH01000009_gene138	1.5e-61	213.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,4NFRF@976|Bacteroidetes,2FMI7@200643|Bacteroidia,22TZM@171550|Rikenellaceae	976|Bacteroidetes	E	B12 binding domain	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_1092321_1	313624.NSP_28080	1.25e-07	53.5	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1GQTV@1117|Cyanobacteria	1117|Cyanobacteria	C	CoA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
k59_1092321_2	1382356.JQMP01000003_gene1440	1.3e-20	92.4	COG0589@1|root,COG0589@2|Bacteria,2G768@200795|Chloroflexi,27Y8A@189775|Thermomicrobia	189775|Thermomicrobia	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_1536167_1	1234595.C725_2313	9.58e-12	64.3	COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,2TQMT@28211|Alphaproteobacteria,4BPF4@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
k59_1536167_2	652103.Rpdx1_2204	4.92e-64	206.0	COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,2TT6A@28211|Alphaproteobacteria,3JRQB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
k59_1260570_1	1150469.RSPPHO_01872	1.72e-81	254.0	COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,2TRKY@28211|Alphaproteobacteria,2JPN1@204441|Rhodospirillales	204441|Rhodospirillales	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
k59_257111_1	313596.RB2501_00441	1.83e-102	317.0	COG0380@1|root,COG1877@1|root,COG0380@2|Bacteria,COG1877@2|Bacteria,4NGJ4@976|Bacteroidetes,1HWRA@117743|Flavobacteriia	976|Bacteroidetes	G	COG0380 Trehalose-6-phosphate synthase	otsB	-	2.4.1.15,3.1.3.12	ko:K16055	ko00500,ko01100,map00500,map01100	-	R02737,R02778	RC00005,RC00017,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT20	-	Glyco_transf_20,Trehalose_PPase
k59_590877_1	1262449.CP6013_2218	2.44e-60	207.0	COG0358@1|root,COG0358@2|Bacteria,1TQ0X@1239|Firmicutes,2480W@186801|Clostridia,36FK8@31979|Clostridiaceae	186801|Clostridia	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
k59_982357_1	1229780.BN381_450096	9.27e-63	199.0	COG0088@1|root,COG0088@2|Bacteria,2GJYJ@201174|Actinobacteria,3UWGH@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	Forms part of the polypeptide exit tunnel	rplD	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0019538,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
k59_1592742_1	861299.J421_5716	1.6e-24	107.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_1092361_1	177437.HRM2_44510	2.82e-39	142.0	COG2801@1|root,COG2801@2|Bacteria,1P5SB@1224|Proteobacteria,42YNG@68525|delta/epsilon subdivisions,2WU6B@28221|Deltaproteobacteria,2MN61@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Integrase	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_1092361_2	379066.GAU_3508	1.81e-17	83.6	COG4584@1|root,COG4584@2|Bacteria,1ZV8R@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_1315841_1	177437.HRM2_48810	7.66e-45	164.0	COG1506@1|root,COG1506@2|Bacteria,1MUJ3@1224|Proteobacteria,42Q8W@68525|delta/epsilon subdivisions,2WJVN@28221|Deltaproteobacteria,2MN2K@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Acetyl xylan esterase (AXE1)	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
k59_482657_1	926569.ANT_08340	8.61e-36	132.0	COG1894@1|root,COG1894@2|Bacteria,2G5W1@200795|Chloroflexi	200795|Chloroflexi	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	nuoF	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
k59_482657_2	926569.ANT_08350	6.26e-29	115.0	COG0243@1|root,COG1034@1|root,COG0243@2|Bacteria,COG1034@2|Bacteria	2|Bacteria	C	ATP synthesis coupled electron transport	nuoG	GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009405,GO:0010941,GO:0016020,GO:0016491,GO:0016651,GO:0030312,GO:0033668,GO:0035821,GO:0042981,GO:0043067,GO:0043069,GO:0044003,GO:0044068,GO:0044403,GO:0044419,GO:0044464,GO:0044531,GO:0044532,GO:0048037,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051536,GO:0051540,GO:0051701,GO:0051704,GO:0051817,GO:0052040,GO:0052041,GO:0052150,GO:0052248,GO:0052433,GO:0052490,GO:0055114,GO:0060548,GO:0065007,GO:0071944	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_314625_1	523845.AQXV01000050_gene1025	5.37e-23	99.4	COG0648@1|root,arCOG01894@2157|Archaea,2XU62@28890|Euryarchaeota,23Q7X@183939|Methanococci	183939|Methanococci	G	PFAM Xylose isomerase domain protein TIM barrel	-	GO:0003674,GO:0003824,GO:0003906,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
k59_868692_1	1047013.AQSP01000102_gene979	3.97e-47	174.0	COG0841@1|root,COG0841@2|Bacteria,2NQF8@2323|unclassified Bacteria	2|Bacteria	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1705277_2	1236902.ANAS01000006_gene5175	2.25e-08	57.0	COG3675@1|root,COG3675@2|Bacteria,2GND0@201174|Actinobacteria	201174|Actinobacteria	I	Lamin Tail Domain	-	-	-	-	-	-	-	-	-	-	-	-	LTD
k59_535972_1	237368.SCABRO_01978	1.23e-39	143.0	COG1235@1|root,COG1235@2|Bacteria,2IXEB@203682|Planctomycetes	203682|Planctomycetes	S	of the beta-lactamase superfamily I	-	-	3.1.4.55	ko:K06167	ko00440,map00440	-	R10205	RC00296	ko00000,ko00001,ko01000	-	-	-	Lactamase_B_2
k59_90976_1	525904.Tter_2233	1.28e-42	159.0	COG1529@1|root,COG1529@2|Bacteria,2NNTR@2323|unclassified Bacteria	2|Bacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	coxL	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_1481772_1	1111479.AXAR01000007_gene1022	1.81e-05	45.1	COG0799@1|root,COG0799@2|Bacteria,1VA2Z@1239|Firmicutes,4HKEJ@91061|Bacilli,278I1@186823|Alicyclobacillaceae	91061|Bacilli	J	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	GO:0003674,GO:0005488,GO:0006417,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043023,GO:0044087,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:0090069,GO:0090071,GO:2000112,GO:2000113	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
k59_1481772_2	1401065.HMPREF2130_02850	6.46e-27	112.0	COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,2VHT1@28216|Betaproteobacteria,3T2G5@506|Alcaligenaceae	28216|Betaproteobacteria	J	Catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
k59_1645923_1	1146883.BLASA_0210	1.14e-91	284.0	COG0535@1|root,COG0775@1|root,COG0535@2|Bacteria,COG0775@2|Bacteria,2HTDD@201174|Actinobacteria,4ES4M@85013|Frankiales	201174|Actinobacteria	F	PFAM Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3463,Fer4_14,Radical_SAM
k59_1092403_1	936574.HMPREF1508_0672	3.01e-44	159.0	COG1774@1|root,COG1774@2|Bacteria,1TP1V@1239|Firmicutes,247Q6@186801|Clostridia	186801|Clostridia	K	domain protein	yaaT	-	-	-	-	-	-	-	-	-	-	-	PSP1
k59_535991_1	649831.L083_3003	5.08e-58	190.0	COG1028@1|root,COG1028@2|Bacteria,2GJU1@201174|Actinobacteria,4D8JK@85008|Micromonosporales	201174|Actinobacteria	IQ	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_927755_1	1392490.JHZX01000001_gene1677	1.29e-90	287.0	COG5009@1|root,COG5009@2|Bacteria,4NECJ@976|Bacteroidetes,1HXWX@117743|Flavobacteriia	976|Bacteroidetes	M	penicillin-binding protein	mrcA	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
k59_982430_1	666684.AfiDRAFT_1064	3.45e-80	247.0	COG1957@1|root,COG1957@2|Bacteria,1NF7X@1224|Proteobacteria,2UGA6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	Protein of unknown function, DUF547	-	-	-	-	-	-	-	-	-	-	-	-	DUF547
k59_1594732_1	1121104.AQXH01000002_gene717	4.28e-25	109.0	COG4447@1|root,COG4447@2|Bacteria,4NESU@976|Bacteroidetes,1IW7V@117747|Sphingobacteriia	976|Bacteroidetes	S	Sortilin, neurotensin receptor 3,	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
k59_537752_1	1121406.JAEX01000014_gene2329	6.22e-45	161.0	COG0143@1|root,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,42N1K@68525|delta/epsilon subdivisions,2WIT6@28221|Deltaproteobacteria,2M8FJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
k59_36773_1	1341679.P253_01390	7.23e-09	56.2	COG0288@1|root,COG0288@2|Bacteria,1NGFN@1224|Proteobacteria,1S237@1236|Gammaproteobacteria,3NIUD@468|Moraxellaceae	1236|Gammaproteobacteria	P	Reversible hydration of carbon dioxide	cynT	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
k59_36773_2	1304875.JAFZ01000002_gene336	1.68e-26	104.0	COG1752@1|root,COG1752@2|Bacteria,3TC9C@508458|Synergistetes	508458|Synergistetes	S	Patatin-like phospholipase	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
k59_1204843_1	218284.CCDN010000001_gene1968	1.82e-28	114.0	COG0673@1|root,COG0673@2|Bacteria,1TQ72@1239|Firmicutes,4HCS4@91061|Bacilli,1ZCPA@1386|Bacillus	91061|Bacilli	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_36778_1	1265503.KB905172_gene407	4.06e-47	168.0	COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,1S1PK@1236|Gammaproteobacteria,2Q8B4@267889|Colwelliaceae	1236|Gammaproteobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_1707235_1	485913.Krac_3408	1.83e-37	141.0	COG0477@1|root,COG2814@2|Bacteria,2G5SP@200795|Chloroflexi	200795|Chloroflexi	P	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
k59_705706_2	1385519.N801_04205	3.28e-31	120.0	COG3547@1|root,COG3547@2|Bacteria,2GS79@201174|Actinobacteria,4FFP0@85021|Intrasporangiaceae	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_92819_1	485915.Dret_0911	3.66e-108	328.0	COG3119@1|root,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,42U6J@68525|delta/epsilon subdivisions,2WKXY@28221|Deltaproteobacteria,2MATE@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Sulfatase	-	-	3.1.6.1,3.1.6.6	ko:K01130,ko:K01133	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Choline_sulf_C,DUF4976,Sulfatase
k59_92819_2	66692.ABC3582	2.97e-12	68.2	COG0644@1|root,COG0644@2|Bacteria,1TR0D@1239|Firmicutes,4HBWH@91061|Bacilli,1ZDCV@1386|Bacillus	91061|Bacilli	C	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_oxidored
k59_1040646_1	756272.Plabr_1087	5.6e-52	173.0	COG1063@1|root,COG1063@2|Bacteria,2IX2U@203682|Planctomycetes	203682|Planctomycetes	C	Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate	tdh	-	1.1.1.103	ko:K00060	ko00260,map00260	-	R01465	RC00525	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_1594793_1	1236689.MMALV_01830	5.33e-07	57.0	COG0644@1|root,arCOG00570@2157|Archaea,2XUI9@28890|Euryarchaeota,3F2N1@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	geranylgeranyl reductase	bchP	-	1.5.5.1	ko:K00311	-	-	-	-	ko00000,ko01000	-	-	-	FAD_binding_3,HI0933_like
k59_1759243_2	314271.RB2654_17946	9.52e-21	97.4	COG0500@1|root,COG2226@2|Bacteria,1MW7J@1224|Proteobacteria,2TSZC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	O-methyltransferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Dimerisation2,Methyltransf_2
k59_1262802_1	290397.Adeh_2998	8.58e-56	196.0	COG2224@1|root,COG2225@1|root,COG2224@2|Bacteria,COG2225@2|Bacteria,1MVEV@1224|Proteobacteria,42P3R@68525|delta/epsilon subdivisions,2X349@28221|Deltaproteobacteria,2YU6W@29|Myxococcales	28221|Deltaproteobacteria	H	Malate synthase	aceB	-	2.3.3.9	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472	RC00004,RC00308,RC02747	ko00000,ko00001,ko00002,ko01000	-	-	-	Hemerythrin,ICL,Malate_synthase
k59_1427298_1	657322.FPR_16880	2.42e-06	53.9	COG1266@1|root,COG1266@2|Bacteria,1V416@1239|Firmicutes,24MKP@186801|Clostridia,3WMQU@541000|Ruminococcaceae	186801|Clostridia	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
k59_815741_1	926549.KI421517_gene2420	4.48e-33	126.0	COG0577@1|root,COG0577@2|Bacteria,4NDUK@976|Bacteroidetes,47MUE@768503|Cytophagia	976|Bacteroidetes	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_36818_1	373994.Riv7116_5062	3.62e-65	216.0	COG3387@1|root,COG3387@2|Bacteria,1G3VS@1117|Cyanobacteria	1117|Cyanobacteria	G	COG3387 Glucoamylase and related glycosyl hydrolases	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_15
k59_1372481_1	1122221.JHVI01000007_gene2170	8.25e-36	125.0	COG4101@1|root,COG4101@2|Bacteria	2|Bacteria	G	3-hydroxyanthranilate 3,4-dioxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_1372481_2	861299.J421_0538	3.33e-24	100.0	COG0733@1|root,COG0733@2|Bacteria	2|Bacteria	S	neurotransmitter:sodium symporter activity	-	-	-	ko:K03308	-	-	-	-	ko00000	2.A.22.4,2.A.22.5	-	-	SNF
k59_929842_1	330214.NIDE3769	7.84e-53	173.0	COG0529@1|root,COG0529@2|Bacteria	2|Bacteria	P	adenylylsulfate kinase activity	cysC	-	2.7.1.25,2.7.7.4	ko:K00860,ko:K00955	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176	R00509,R00529,R04928,R04929	RC00002,RC00078,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase
k59_929842_2	192952.MM_2076	2.16e-17	81.6	COG1812@1|root,arCOG01678@2157|Archaea,2Y2VT@28890|Euryarchaeota,2NA91@224756|Methanomicrobia	224756|Methanomicrobia	E	S-adenosylmethionine synthetase (AdoMet synthetase)	-	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_Synthase
k59_1372484_1	1340493.JNIF01000003_gene2647	6.38e-33	132.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_370859_1	1173027.Mic7113_5447	9.72e-40	147.0	COG0277@1|root,COG0277@2|Bacteria,1G176@1117|Cyanobacteria,1H7RA@1150|Oscillatoriales	1117|Cyanobacteria	C	FAD linked oxidases, C-terminal domain	glcE	-	-	ko:K11472	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_1707281_1	215803.DB30_3707	2.36e-16	78.6	COG3568@1|root,COG3568@2|Bacteria,1N29G@1224|Proteobacteria,438Z7@68525|delta/epsilon subdivisions,2X8PT@28221|Deltaproteobacteria,2YY8K@29|Myxococcales	28221|Deltaproteobacteria	S	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
k59_537832_1	469383.Cwoe_3701	8.05e-20	100.0	COG1200@1|root,COG1200@2|Bacteria,2GKA3@201174|Actinobacteria,4CPM1@84995|Rubrobacteria	84995|Rubrobacteria	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
k59_1594827_1	398720.MED217_06631	1.23e-68	224.0	COG2272@1|root,COG2272@2|Bacteria,4NF5N@976|Bacteroidetes,1HZ06@117743|Flavobacteriia,2XK9G@283735|Leeuwenhoekiella	976|Bacteroidetes	I	Carboxylesterase family	-	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase
k59_1204911_1	1279009.ADICEAN_02653	2.5e-32	129.0	COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria,4NERT@976|Bacteroidetes,47JGX@768503|Cytophagia	976|Bacteroidetes	MU	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	BSP,PD40
k59_316769_1	1121405.dsmv_2002	5.35e-06	48.1	COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,42NJD@68525|delta/epsilon subdivisions,2WJFK@28221|Deltaproteobacteria,2MHNT@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Belongs to the peptidase S16 family	-	-	3.4.21.53	ko:K04076	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AAA_32,Lon_C,Mg_chelatase
k59_316769_2	323261.Noc_1573	6.78e-32	116.0	COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,1S7QZ@1236|Gammaproteobacteria,1WYRM@135613|Chromatiales	135613|Chromatiales	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
k59_36846_2	469371.Tbis_0512	2.98e-07	57.0	COG0310@1|root,COG0310@2|Bacteria,2GK2U@201174|Actinobacteria,4DZUB@85010|Pseudonocardiales	201174|Actinobacteria	P	Cobalt uptake substrate-specific transmembrane region	cbiM	-	-	ko:K02007	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiM,PDGLE
k59_870791_1	1121878.AUGL01000014_gene1714	5.57e-15	74.7	COG0777@1|root,COG0777@2|Bacteria,1MW8G@1224|Proteobacteria,1RNDS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	GO:0001676,GO:0003674,GO:0003676,GO:0003677,GO:0003723,GO:0003729,GO:0003824,GO:0003989,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006417,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008270,GO:0008610,GO:0009058,GO:0009317,GO:0009329,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016053,GO:0016421,GO:0016874,GO:0016885,GO:0017148,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032787,GO:0032991,GO:0034248,GO:0034249,GO:0042759,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:0097159,GO:1901363,GO:1901576,GO:1902494,GO:1990234,GO:2000112,GO:2000113	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	iPC815.YPO2768,iUTI89_1310.UTI89_C2601	Carboxyl_trans
k59_870791_2	452637.Oter_0292	1.52e-15	77.8	COG0772@1|root,COG0772@2|Bacteria,46SQT@74201|Verrucomicrobia,3K7H4@414999|Opitutae	414999|Opitutae	D	Belongs to the SEDS family	-	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
k59_147781_2	1232410.KI421426_gene1372	2.36e-23	99.4	COG1554@1|root,COG1554@2|Bacteria,1MWJE@1224|Proteobacteria,42Q4Z@68525|delta/epsilon subdivisions,2WM28@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	PFAM Glycoside hydrolase family 65, central catalytic	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m,HAD_2,Hydrolase
k59_484502_1	941449.dsx2_1281	9.47e-19	82.0	COG0599@1|root,COG0599@2|Bacteria,1N2ZQ@1224|Proteobacteria,42VDR@68525|delta/epsilon subdivisions,2WRKS@28221|Deltaproteobacteria,2MDBQ@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM Carboxymuconolactone decarboxylase	-	-	-	-	-	-	-	-	-	-	-	-	CMD
k59_592869_1	1071073.KI530536_gene926	7.09e-44	157.0	COG0010@1|root,COG0010@2|Bacteria,1TP2A@1239|Firmicutes,4HCKQ@91061|Bacilli,1ZBPI@1386|Bacillus	91061|Bacilli	E	Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide	hutG	-	3.5.3.8	ko:K01479	ko00340,ko01100,map00340,map01100	M00045	R02285	RC00221,RC00681	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
k59_1759284_1	1379270.AUXF01000003_gene3556	2.36e-119	360.0	COG0443@1|root,COG0443@2|Bacteria,1ZT75@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
k59_647299_1	926560.KE387027_gene540	5.67e-117	351.0	COG2939@1|root,COG2939@2|Bacteria,1WJMU@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Serine carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S10
k59_760036_1	357808.RoseRS_3781	5.47e-22	97.1	COG0770@1|root,COG0770@2|Bacteria,2G5PN@200795|Chloroflexi,374X6@32061|Chloroflexia	32061|Chloroflexia	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_163058_1	1125863.JAFN01000001_gene2149	0.000576	43.5	COG0705@1|root,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,42P0V@68525|delta/epsilon subdivisions,2WJGR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	PFAM Rhomboid family	-	-	-	ko:K07059	-	-	-	-	ko00000	-	-	-	DnaJ_C,Rhomboid
k59_163058_2	1267535.KB906767_gene733	5.58e-08	54.3	COG0492@1|root,COG3437@1|root,COG0492@2|Bacteria,COG3437@2|Bacteria,3Y3TK@57723|Acidobacteria	57723|Acidobacteria	KOT	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_3,Response_reg
k59_944978_1	36080.S2KF37	1.14e-19	92.8	COG0367@1|root,KOG0571@2759|Eukaryota,38H99@33154|Opisthokonta,3NVCE@4751|Fungi,1GW20@112252|Fungi incertae sedis	4751|Fungi	E	Aluminium induced protein	ASN1	GO:0003674,GO:0003824,GO:0004066,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006528,GO:0006529,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0032787,GO:0034641,GO:0042802,GO:0042803,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046983,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
k59_500051_1	196162.Noca_4031	2.6e-66	218.0	COG1012@1|root,COG1012@2|Bacteria,2GJI2@201174|Actinobacteria,4DQ06@85009|Propionibacteriales	201174|Actinobacteria	C	Aldehyde dehydrogenase family	-	-	1.2.1.10	ko:K00132	ko00620,ko00650,ko01100,ko01120,map00620,map00650,map01100,map01120	-	R00228,R01172	RC00004,RC00184,RC01195	ko00000,ko00001,ko01000	-	-	-	Aldedh
k59_721822_1	768679.TTX_0482	2.89e-06	54.7	COG0683@1|root,arCOG01020@2157|Archaea,2XQM1@28889|Crenarchaeota	28889|Crenarchaeota	E	Periplasmic binding protein	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_661062_1	225937.HP15_2995	5.01e-42	147.0	COG1028@1|root,COG1028@2|Bacteria,1MUUV@1224|Proteobacteria,1RMJU@1236|Gammaproteobacteria,466CG@72275|Alteromonadaceae	1236|Gammaproteobacteria	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	ycdF	-	1.5.1.33	ko:K03793	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
k59_887267_1	1168065.DOK_16933	3.23e-23	92.8	COG3063@1|root,COG3063@2|Bacteria,1N2T8@1224|Proteobacteria,1S9R8@1236|Gammaproteobacteria,1J72A@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	NU	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_14,TPR_16,TPR_19,TPR_2
k59_830382_1	1123248.KB893326_gene1351	1.38e-11	70.5	COG3278@1|root,COG3278@2|Bacteria,4NGGE@976|Bacteroidetes,1IRUF@117747|Sphingobacteriia	976|Bacteroidetes	O	Belongs to the heme-copper respiratory oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_945010_1	195253.Syn6312_2263	7.84e-07	51.2	COG0842@1|root,COG1131@1|root,COG1716@1|root,COG0842@2|Bacteria,COG1131@2|Bacteria,COG1716@2|Bacteria,1G102@1117|Cyanobacteria,1H2EK@1129|Synechococcus	1117|Cyanobacteria	TV	ABC-type multidrug transport system, ATPase component	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane,ABC_tran,FHA
k59_945010_2	997346.HMPREF9374_2085	3.4e-36	128.0	COG0457@1|root,COG0457@2|Bacteria,1V3U6@1239|Firmicutes,4HFWW@91061|Bacilli,27CYZ@186824|Thermoactinomycetaceae	91061|Bacilli	S	Tetratrico peptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_5,TPR_6,TPR_8
k59_605791_1	1232410.KI421424_gene1758	7.54e-93	283.0	COG5557@1|root,COG5557@2|Bacteria,1PFX4@1224|Proteobacteria,42NUN@68525|delta/epsilon subdivisions,2WJHN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Polysulphide reductase, NrfD	-	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	NrfD
k59_441193_1	1121930.AQXG01000012_gene3236	1.66e-08	57.4	COG2911@1|root,COG5295@1|root,COG2911@2|Bacteria,COG5295@2|Bacteria,4NMJW@976|Bacteroidetes	976|Bacteroidetes	UW	Hep Hag repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1566,Peptidase_S74
k59_773235_1	926569.ANT_02660	1.51e-53	175.0	COG1117@1|root,COG1117@2|Bacteria,2G646@200795|Chloroflexi	200795|Chloroflexi	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	GO:0003674,GO:0003824,GO:0005215,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015114,GO:0015318,GO:0015399,GO:0015405,GO:0015415,GO:0015698,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0034220,GO:0035435,GO:0042623,GO:0042626,GO:0043225,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0098656,GO:0098660,GO:0098661,GO:0099133	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
k59_333280_2	485913.Krac_4901	2.02e-08	58.5	COG2378@1|root,COG2378@2|Bacteria,2G8BW@200795|Chloroflexi	200795|Chloroflexi	K	Helix-turn-helix type 11 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,WYL
k59_605802_1	1121445.ATUZ01000015_gene1809	1.61e-83	264.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,42NY8@68525|delta/epsilon subdivisions,2WJNT@28221|Deltaproteobacteria,2M8JT@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k59_605802_2	273121.WS1822	7.72e-06	48.1	COG2823@1|root,COG2823@2|Bacteria,1N0SU@1224|Proteobacteria,42VD3@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	SMART Transport-associated and nodulation region	osmY_2	-	-	ko:K04065	-	-	-	-	ko00000	-	-	-	BON
k59_215560_1	1122603.ATVI01000011_gene2077	2.44e-128	383.0	COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,1RP1F@1236|Gammaproteobacteria,1X4N0@135614|Xanthomonadales	135614|Xanthomonadales	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC-associated,ThiC_Rad_SAM
k59_1111397_2	888050.HMPREF9004_1894	1.7e-11	67.4	COG0489@1|root,COG0489@2|Bacteria,2GJUZ@201174|Actinobacteria,4D45F@85005|Actinomycetales	201174|Actinobacteria	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	mrp	GO:0008150,GO:0040007	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
k59_1111404_1	794903.OPIT5_18985	6.31e-72	238.0	COG0370@1|root,COG0370@2|Bacteria,46SH4@74201|Verrucomicrobia,3K85F@414999|Opitutae	414999|Opitutae	P	transporter of a GTP-driven Fe(2 ) uptake system	-	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
k59_273881_1	926569.ANT_00090	9.61e-56	182.0	COG0330@1|root,COG0330@2|Bacteria,2G5SB@200795|Chloroflexi	2|Bacteria	O	PFAM band 7 protein	hflC	-	-	-	-	-	-	-	-	-	-	-	Band_7
k59_273881_2	192952.MM_0383	7.23e-07	50.8	COG5658@1|root,arCOG04484@2157|Archaea,2XVWE@28890|Euryarchaeota,2NB7Z@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF1648)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1648,SdpI
k59_1777632_1	926550.CLDAP_20690	5.49e-51	175.0	COG0577@1|root,COG0577@2|Bacteria,2G6RX@200795|Chloroflexi	200795|Chloroflexi	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	-
k59_553212_1	1121127.JAFA01000053_gene299	1.12e-19	88.6	COG3971@1|root,COG3971@2|Bacteria,1MVVV@1224|Proteobacteria,2VJEE@28216|Betaproteobacteria,1K1Q4@119060|Burkholderiaceae	28216|Betaproteobacteria	Q	hydratase	-	-	4.2.1.80	ko:K02554	ko00360,ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00360,map00362,map00621,map00622,map01100,map01120,map01220	M00545,M00569	R02601,R04781	RC00750,RC01213	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	FAA_hydrolase
k59_165285_1	31033.ENSTRUP00000025077	4.56e-05	50.4	KOG0271@1|root,KOG0271@2759|Eukaryota,39NRR@33154|Opisthokonta,3CQA8@33208|Metazoa,3E6FS@33213|Bilateria,48RYF@7711|Chordata,49ND3@7742|Vertebrata,4A8P5@7898|Actinopterygii	33208|Metazoa	S	WD repeat-containing protein	wdr17	-	-	-	-	-	-	-	-	-	-	-	WD40
k59_607614_1	572477.Alvin_1382	2.43e-13	74.7	COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,1RNPZ@1236|Gammaproteobacteria,1WW15@135613|Chromatiales	135613|Chromatiales	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	SMC_N
k59_999205_1	926569.ANT_20900	1.15e-66	219.0	COG0318@1|root,COG0318@2|Bacteria,2G5Q8@200795|Chloroflexi	200795|Chloroflexi	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
k59_663313_1	1191523.MROS_1373	2.64e-66	214.0	COG0436@1|root,COG0436@2|Bacteria	2|Bacteria	E	Aminotransferase	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_443576_1	907348.TresaDRAFT_0622	3.01e-49	174.0	COG1653@1|root,COG1653@2|Bacteria,2J66Q@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Bacterial extracellular solute-binding	-	-	-	ko:K17318	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	SBP_bac_1,SBP_bac_8
k59_1111470_1	497964.CfE428DRAFT_2900	1.53e-61	197.0	COG3547@1|root,COG3547@2|Bacteria	2|Bacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1552653_1	861299.J421_3231	1.44e-52	186.0	COG0322@1|root,COG0322@2|Bacteria,1ZSXE@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_5,UVR,UvrC_HhH_N
k59_109134_1	998674.ATTE01000001_gene1873	9.27e-30	122.0	COG0769@1|root,COG0769@2|Bacteria,1R52S@1224|Proteobacteria,1RVEK@1236|Gammaproteobacteria,460EQ@72273|Thiotrichales	72273|Thiotrichales	M	Mur ligase middle domain	-	-	-	-	-	-	-	-	-	-	-	-	Mur_ligase_C,Mur_ligase_M
k59_387799_1	323098.Nwi_0773	2.58e-38	140.0	COG2010@1|root,COG2010@2|Bacteria,1MYNE@1224|Proteobacteria,2V9Z1@28211|Alphaproteobacteria,3K5DU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
k59_1664567_1	926569.ANT_29860	1.05e-24	99.0	2A540@1|root,30TSN@2|Bacteria,2G9TT@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_663362_1	861299.J421_5718	1.77e-27	115.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_443632_1	861299.J421_6229	6.3e-47	172.0	COG2373@1|root,COG2373@2|Bacteria	2|Bacteria	U	Large extracellular alpha-helical protein	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,Big_5,MG1,Thiol-ester_cl
k59_217409_1	713586.KB900536_gene1501	3.15e-14	72.8	COG0500@1|root,COG1047@1|root,COG1047@2|Bacteria,COG2226@2|Bacteria,1PCH2@1224|Proteobacteria,1S09M@1236|Gammaproteobacteria,1X09N@135613|Chromatiales	135613|Chromatiales	OQ	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_217409_2	1217658.F987_02453	2.36e-15	79.3	COG0642@1|root,COG0834@1|root,COG0834@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1RQCU@1236|Gammaproteobacteria,3NT1A@468|Moraxellaceae	1236|Gammaproteobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	evgS	GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009268,GO:0009628,GO:0009927,GO:0009987,GO:0010447,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0035556,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007,GO:0071704,GO:0140096,GO:1901564	2.7.13.3	ko:K07677,ko:K07679	ko02020,ko02026,ko05133,map02020,map02026,map05133	M00474,M00477	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,Response_reg,SBP_bac_3
k59_109180_1	748247.AZKH_4006	5.18e-53	186.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,2VHF3@28216|Betaproteobacteria,2KV0Q@206389|Rhodocyclales	206389|Rhodocyclales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_1220402_2	765420.OSCT_0406	2.39e-37	135.0	COG0209@1|root,COG0209@2|Bacteria	2|Bacteria	F	ribonucleoside-diphosphate reductase activity	nrdZ	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN,TSCPD
k59_109186_1	1120956.JHZK01000025_gene2018	7.31e-79	250.0	COG0318@1|root,COG0318@2|Bacteria,1MUMC@1224|Proteobacteria,2TR96@28211|Alphaproteobacteria,1JNGP@119043|Rhodobiaceae	28211|Alphaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	MA20_29420	-	6.2.1.48	ko:K00666,ko:K02182	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_1552723_1	1336243.JAEA01000006_gene386	4.78e-45	159.0	COG1295@1|root,COG1295@2|Bacteria,1MXQA@1224|Proteobacteria,2TSFP@28211|Alphaproteobacteria,1JRP9@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	ribonuclease BN	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
k59_775285_1	379066.GAU_2144	4.5e-72	234.0	COG1217@1|root,COG1217@2|Bacteria,1ZT8A@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Elongation factor G C-terminus	-	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
k59_387846_1	861299.J421_0375	1.5e-116	348.0	COG2271@1|root,COG2271@2|Bacteria	2|Bacteria	G	transmembrane transporter activity	-	-	-	ko:K08191	-	-	-	-	ko00000,ko02000	2.A.1.14.2	-	-	MFS_1
k59_1552734_2	1304284.L21TH_2520	3.02e-23	95.5	COG0355@1|root,COG0355@2|Bacteria,1VA89@1239|Firmicutes,24ND7@186801|Clostridia,36MZ0@31979|Clostridiaceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	iHN637.CLJU_RS01195	ATP-synt_DE,ATP-synt_DE_N
k59_775297_1	671143.DAMO_1287	4.04e-50	173.0	COG2801@1|root,COG2801@2|Bacteria,2NQ4I@2323|unclassified Bacteria	2|Bacteria	L	Homeodomain-like domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_28,HTH_32,LZ_Tnp_IS481,rve,rve_3
k59_1611264_1	944479.JQLX01000013_gene1447	6.08e-80	253.0	COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,42M14@68525|delta/epsilon subdivisions,2WIN7@28221|Deltaproteobacteria,2M6KR@213113|Desulfurellales	28221|Deltaproteobacteria	I	Biotin carboxylase C-terminal domain	pccA	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
k59_443723_1	926569.ANT_20580	7.87e-73	229.0	COG0045@1|root,COG0045@2|Bacteria,2G68A@200795|Chloroflexi	200795|Chloroflexi	F	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
k59_1664664_1	324602.Caur_2083	3.51e-16	83.2	COG2211@1|root,COG2211@2|Bacteria,2G6RZ@200795|Chloroflexi,3764D@32061|Chloroflexia	32061|Chloroflexia	G	MFS/sugar transport protein	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
k59_1220467_1	1278073.MYSTI_04140	9.46e-63	217.0	COG0318@1|root,COG1020@1|root,COG3321@1|root,COG0318@2|Bacteria,COG1020@2|Bacteria,COG3321@2|Bacteria,1MU6G@1224|Proteobacteria	1224|Proteobacteria	IQ	COG0318, Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Bac_luciferase,Condensation,KAsynt_C_assoc,Ketoacyl-synt_C,Methyltransf_25,PP-binding,Thioesterase,ketoacyl-synt
k59_1111618_1	331113.SNE_A14260	1.47e-72	229.0	COG1575@1|root,COG1575@2|Bacteria,2JG47@204428|Chlamydiae	204428|Chlamydiae	H	Belongs to the MenA family. Type 1 subfamily	menA	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
k59_217497_1	324057.Pjdr2_0653	5.37e-73	232.0	COG0673@1|root,COG0673@2|Bacteria,1TPT5@1239|Firmicutes,4HAPJ@91061|Bacilli,26TP1@186822|Paenibacillaceae	91061|Bacilli	S	Oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_443742_1	224911.27354266	1.85e-15	79.3	COG0451@1|root,COG0451@2|Bacteria,1QUEV@1224|Proteobacteria,2TW46@28211|Alphaproteobacteria,3JUU7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Male sterility protein	-	-	4.2.1.46,5.1.3.2	ko:K01710,ko:K01784	ko00052,ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00052,map00520,map00521,map00523,map00525,map01055,map01100,map01130	M00361,M00362,M00632,M00793	R00291,R02984,R06513	RC00289,RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
k59_1664684_1	926569.ANT_08730	4.25e-97	310.0	COG0751@1|root,COG0752@1|root,COG0751@2|Bacteria,COG0752@2|Bacteria,2G7V0@200795|Chloroflexi	200795|Chloroflexi	J	Glycyl-tRNA synthetase alpha subunit	glyQS	-	6.1.1.14	ko:K14164	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	tRNA-synt_2e,tRNA_synt_2f
k59_217513_1	1288494.EBAPG3_18410	4.73e-63	216.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,2VHUF@28216|Betaproteobacteria,37271@32003|Nitrosomonadales	28216|Betaproteobacteria	L	DNA topoisomerase, type IA, central	topB	-	5.99.1.2	ko:K03169	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	SWIB,Topoisom_bac,Toprim,Toprim_Crpt
k59_775379_1	358823.DF19_37230	2.48e-26	108.0	COG0477@1|root,COG0477@2|Bacteria,2GK06@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
k59_775379_2	1235797.C816_00544	1.37e-26	108.0	COG0696@1|root,COG0696@2|Bacteria,1TPM4@1239|Firmicutes,247JG@186801|Clostridia,2N7Z2@216572|Oscillospiraceae	186801|Clostridia	G	BPG-independent PGAM N-terminus (iPGM_N)	gpmI	-	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,Phosphodiest,iPGM_N
k59_217525_1	1229780.BN381_20035	4.73e-43	152.0	COG0697@1|root,COG0697@2|Bacteria	2|Bacteria	EG	spore germination	-	-	-	ko:K15270	-	-	-	-	ko00000,ko02000	2.A.7.3.7	-	-	EamA
k59_387963_1	1122218.KB893653_gene1211	5.67e-18	83.6	COG2802@1|root,COG2802@2|Bacteria,1NV9N@1224|Proteobacteria,2TQZ4@28211|Alphaproteobacteria,1JTFK@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Peptidase S16, lon domain protein	lonD	-	3.4.21.53	ko:K01338,ko:K07157	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	LON_substr_bdg
k59_387963_2	570952.ATVH01000013_gene2813	1.85e-15	69.7	COG2835@1|root,COG2835@2|Bacteria,1N6Y2@1224|Proteobacteria,2UF4N@28211|Alphaproteobacteria,2JUCC@204441|Rhodospirillales	204441|Rhodospirillales	S	Belongs to the UPF0434 family	-	-	-	ko:K09791	-	-	-	-	ko00000	-	-	-	Trm112p
k59_1777946_1	96561.Dole_3131	7.94e-45	154.0	COG0714@1|root,COG0714@2|Bacteria,1MV5I@1224|Proteobacteria,42N5A@68525|delta/epsilon subdivisions,2WKKI@28221|Deltaproteobacteria,2MIZW@213118|Desulfobacterales	28221|Deltaproteobacteria	S	AAA ATPase domain	clpB1	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_5
k59_1777946_2	1128421.JAGA01000002_gene792	2.84e-21	87.0	arCOG11507@1|root,333W5@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_775468_1	935261.JAGL01000002_gene1375	8.36e-39	147.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,43I48@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
k59_1220598_1	323850.Shew_1558	4e-59	198.0	COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,1RN93@1236|Gammaproteobacteria,2Q8QB@267890|Shewanellaceae	1236|Gammaproteobacteria	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ASL_C,Lyase_1
k59_775472_1	62928.azo2926	8.24e-26	107.0	COG3103@1|root,COG3103@2|Bacteria,1QVCP@1224|Proteobacteria	1224|Proteobacteria	T	Sh3 type 3 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_217613_2	913865.DOT_3859	1.7e-41	146.0	COG0468@1|root,COG0468@2|Bacteria,1TPD5@1239|Firmicutes,247SF@186801|Clostridia,260U5@186807|Peptococcaceae	186801|Clostridia	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
k59_1611448_1	1237149.C900_01932	1.69e-35	130.0	2DBV7@1|root,2ZB9P@2|Bacteria,4NPQU@976|Bacteroidetes,47QI9@768503|Cytophagia	976|Bacteroidetes	S	Domain of unknown function (DUF4386)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4386
k59_274202_1	187272.Mlg_2623	1.22e-49	170.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RRXX@1236|Gammaproteobacteria,1WXC2@135613|Chromatiales	135613|Chromatiales	T	response regulator receiver	-	-	-	ko:K13599	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1721913_1	1408418.JNJH01000024_gene19	2.74e-05	49.7	COG2982@1|root,COG2982@2|Bacteria,1MUAN@1224|Proteobacteria,2U26R@28211|Alphaproteobacteria,2JPQ3@204441|Rhodospirillales	204441|Rhodospirillales	M	AsmA family	-	-	-	ko:K07289,ko:K07290	-	-	-	-	ko00000	9.B.121	-	-	AsmA,AsmA_2
k59_1721913_2	1126627.BAWE01000005_gene6232	2.86e-08	54.7	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TR2Z@28211|Alphaproteobacteria,3JS63@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	FAD linked oxidases, C-terminal domain	dld	GO:0003674,GO:0003824,GO:0004457,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008720,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0034641,GO:0034654,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046034,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.1.1.303,1.1.1.4,1.1.2.4	ko:K00004,ko:K00102	ko00620,ko00650,map00620,map00650	-	R00197,R02855,R02946,R10504	RC00044,RC00205,RC00525	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_999456_1	379066.GAU_0528	3.14e-45	153.0	COG2316@1|root,COG2316@2|Bacteria,1ZTH6@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	HD
k59_443907_1	861299.J421_3213	2.25e-35	136.0	COG4591@1|root,COG4591@2|Bacteria,1ZT1N@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	MacB-like periplasmic core domain	-	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
k59_443907_2	314607.KB13_349	1.95e-11	63.2	COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,2VH1A@28216|Betaproteobacteria,1KPV0@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
k59_1068542_1	465541.ATCJ01000005_gene4270	4.77e-11	68.2	COG0768@1|root,COG0768@2|Bacteria,2GJUQ@201174|Actinobacteria	201174|Actinobacteria	M	penicillin-binding protein	pbpA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K05364	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01011	-	-	-	Transpeptidase
k59_845767_1	797515.HMPREF9103_00418	2.09e-26	116.0	COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,4HAW9@91061|Bacilli,3F4TZ@33958|Lactobacillaceae	91061|Bacilli	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_290478_1	585543.HMPREF0969_02263	5.63e-71	238.0	COG3391@1|root,COG3391@2|Bacteria,4PMVP@976|Bacteroidetes,2G0IC@200643|Bacteroidia,4AR81@815|Bacteroidaceae	976|Bacteroidetes	S	candidate xyloglucanase, glycoside hydrolase family 74 protein K01238	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_234869_1	861299.J421_2847	2.34e-54	191.0	COG0209@1|root,COG0209@2|Bacteria,1ZSU9@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC,Ribonuc_red_lgN
k59_234872_2	316055.RPE_3950	2.09e-38	132.0	COG3415@1|root,COG3415@2|Bacteria,1RJ69@1224|Proteobacteria,2UCXQ@28211|Alphaproteobacteria,3K69N@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Transposase	-	-	-	ko:K07499	-	-	-	-	ko00000	-	-	-	HTH_23,HTH_28,HTH_32,HTH_Tnp_IS630,HTH_Tnp_Tc3_2
k59_12471_1	351348.Maqu_2422	7.92e-27	112.0	COG0664@1|root,COG1639@1|root,COG0664@2|Bacteria,COG1639@2|Bacteria,1N7EN@1224|Proteobacteria,1RT8G@1236|Gammaproteobacteria,466AI@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	Signal transduction protein	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	HDOD
k59_178836_1	469618.FVAG_00723	5.82e-23	98.6	COG1168@1|root,COG1168@2|Bacteria,37891@32066|Fusobacteria	32066|Fusobacteria	E	Psort location Cytoplasmic, score	-	-	4.4.1.8	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	-	R00782,R01286,R02408,R04941	RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_1013404_2	485913.Krac_12240	1e-35	138.0	COG0322@1|root,COG0322@2|Bacteria,2G651@200795|Chloroflexi	200795|Chloroflexi	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
k59_1238321_2	999611.KI421504_gene489	2.39e-41	155.0	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2TQY9@28211|Alphaproteobacteria,2819I@191028|Leisingera	28211|Alphaproteobacteria	S	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DUF3394,DctM
k59_1181458_2	679197.HMPREF9336_00716	1.4e-47	163.0	COG0604@1|root,COG0604@2|Bacteria,2GKHW@201174|Actinobacteria	201174|Actinobacteria	C	NADPH quinone reductase	qor	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_347095_1	566466.NOR53_23	8.69e-32	122.0	COG0475@1|root,COG0475@2|Bacteria	2|Bacteria	P	glutathione-regulated potassium exporter activity	napA	GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008150,GO:0008324,GO:0009847,GO:0015075,GO:0015077,GO:0015081,GO:0015291,GO:0015297,GO:0015318,GO:0015672,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0032502,GO:0034220,GO:0035725,GO:0044425,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0098655,GO:0098660,GO:0098662	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
k59_1681711_1	521045.Kole_0693	3.52e-30	122.0	COG1653@1|root,COG1653@2|Bacteria,2GCPM@200918|Thermotogae	200918|Thermotogae	G	Extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1
k59_292166_1	1487921.DP68_05615	3.77e-73	239.0	COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,248JC@186801|Clostridia,36FW3@31979|Clostridiaceae	186801|Clostridia	IQ	AMP-binding enzyme	fadD	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
k59_625106_1	1124780.ANNU01000036_gene34	3.83e-47	170.0	COG0531@1|root,COG0531@2|Bacteria,4NFFX@976|Bacteroidetes,47M9P@768503|Cytophagia	976|Bacteroidetes	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease
k59_569539_2	1379270.AUXF01000002_gene1608	2.2e-05	48.5	COG1131@1|root,COG1131@2|Bacteria,1ZUT7@142182|Gemmatimonadetes	142182|Gemmatimonadetes	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1737258_1	765914.ThisiDRAFT_2791	4.82e-42	153.0	COG0399@1|root,COG0399@2|Bacteria,1MUMJ@1224|Proteobacteria,1RSDY@1236|Gammaproteobacteria,1X0B5@135613|Chromatiales	135613|Chromatiales	M	Transposase zinc-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
k59_1459798_1	404589.Anae109_1549	2.71e-24	106.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,1MV1P@1224|Proteobacteria,42PPB@68525|delta/epsilon subdivisions,2X5YN@28221|Deltaproteobacteria,2YUEJ@29|Myxococcales	28221|Deltaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_10,TPR_12
k59_14169_1	1121272.KB903292_gene4002	9.41e-33	125.0	COG1105@1|root,COG1105@2|Bacteria,2HTUE@201174|Actinobacteria,4D8IF@85008|Micromonosporales	201174|Actinobacteria	G	pfkB family carbohydrate kinase	-	-	2.7.1.56	ko:K00882	ko00051,map00051	-	R02071	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
k59_347123_1	319236.JCM19294_2891	2.11e-67	218.0	COG0626@1|root,COG0626@2|Bacteria,4NIV1@976|Bacteroidetes,1HXIF@117743|Flavobacteriia,3HJYF@363408|Nonlabens	976|Bacteroidetes	E	Cys/Met metabolism PLP-dependent enzyme	-	-	4.4.1.11	ko:K01761	ko00270,ko00450,map00270,map00450	-	R00654,R04770	RC00196,RC00348,RC01209,RC01210	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
k59_792622_1	1121920.AUAU01000004_gene593	1.15e-35	125.0	COG3070@1|root,COG3070@2|Bacteria	2|Bacteria	K	positive regulation of type IV pilus biogenesis	-	-	-	ko:K07343	-	-	-	-	ko00000	-	-	-	TfoX_N
k59_1126535_1	717785.HYPMC_3549	5.3e-52	176.0	COG0391@1|root,COG0391@2|Bacteria,1NK78@1224|Proteobacteria,2TUUA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	LPPG Fo 2-phospho-L-lactate transferase	cofD	-	2.7.8.28	ko:K11212	ko00680,ko01120,map00680,map01120	M00378	R09398	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	UPF0052
k59_124638_1	68194.JNXR01000004_gene4561	5.04e-75	233.0	COG2197@1|root,COG2197@2|Bacteria,2IIDD@201174|Actinobacteria	201174|Actinobacteria	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_904134_1	1088721.NSU_3804	6.46e-71	225.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria,2K04I@204457|Sphingomonadales	204457|Sphingomonadales	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_1737298_1	382245.ASA_1949	1.59e-89	288.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,1RN03@1236|Gammaproteobacteria,1Y403@135624|Aeromonadales	135624|Aeromonadales	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_403184_1	1121434.AULY01000010_gene2550	1.52e-20	94.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,2M7S1@213115|Desulfovibrionales	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_403184_2	1415780.JPOG01000001_gene874	8.21e-07	52.0	COG0845@1|root,COG0845@2|Bacteria,1MX0G@1224|Proteobacteria,1RN0S@1236|Gammaproteobacteria,1X433@135614|Xanthomonadales	1236|Gammaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
k59_737109_1	1227499.C493_18836	5.16e-54	183.0	COG1960@1|root,arCOG01707@2157|Archaea,2Y2NE@28890|Euryarchaeota,23ZFQ@183963|Halobacteria	183963|Halobacteria	I	COG1960 Acyl-CoA dehydrogenases	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_1625693_1	187272.Mlg_0715	1.58e-42	147.0	COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,1RMN0@1236|Gammaproteobacteria,1WWI6@135613|Chromatiales	135613|Chromatiales	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
k59_1681775_1	671143.DAMO_3141	1.54e-114	339.0	COG0686@1|root,COG0686@2|Bacteria,2NP43@2323|unclassified Bacteria	2|Bacteria	E	Alanine dehydrogenase/PNT, C-terminal domain	ald	GO:0000286,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009653,GO:0009987,GO:0016054,GO:0016491,GO:0016638,GO:0019752,GO:0030154,GO:0030435,GO:0032502,GO:0043436,GO:0043934,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0048646,GO:0048856,GO:0048869,GO:0055114,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_1099	AlaDh_PNT_C,AlaDh_PNT_N
k59_569592_1	926569.ANT_18920	1.37e-67	218.0	COG0330@1|root,COG0330@2|Bacteria	2|Bacteria	O	stress-induced mitochondrial fusion	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
k59_1070258_1	926569.ANT_16000	3.08e-39	143.0	COG0836@1|root,COG0836@2|Bacteria,2G5WW@200795|Chloroflexi	200795|Chloroflexi	M	Nucleotidyl transferase	-	-	2.7.7.13	ko:K00971	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
k59_1459857_2	237368.SCABRO_03239	1.37e-15	80.1	COG4198@1|root,COG4198@2|Bacteria,2IX7C@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF1015)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
k59_847432_1	644966.Tmar_1319	2.82e-42	159.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,3WCV1@538999|Clostridiales incertae sedis	186801|Clostridia	V	ABC-type multidrug transport system ATPase and permease	-	-	-	ko:K18889	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106.13,3.A.1.106.5	-	-	ABC_membrane,ABC_tran
k59_347182_1	1121441.AUCX01000006_gene830	8.59e-35	131.0	COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,42M04@68525|delta/epsilon subdivisions,2WJJD@28221|Deltaproteobacteria,2M7T1@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
k59_347182_2	866895.HBHAL_1106	2.52e-25	105.0	COG0245@1|root,COG1211@1|root,COG0245@2|Bacteria,COG1211@2|Bacteria,1V3P0@1239|Firmicutes,4HG1X@91061|Bacilli,3NEHS@45667|Halobacillus	91061|Bacilli	I	(ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	2.7.7.60,4.6.1.12	ko:K01770,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	YgbB
k59_1015174_1	1430331.EP10_01455	7.14e-44	164.0	COG0620@1|root,COG0620@2|Bacteria,1TP2H@1239|Firmicutes,4H9QC@91061|Bacilli	91061|Bacilli	E	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation	metE	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003871,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019752,GO:0032259,GO:0042084,GO:0042085,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050667,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_1,Meth_synt_2
k59_236692_2	1159488.SEQMU2_13280	3.48e-05	48.9	COG1816@1|root,COG1816@2|Bacteria,1U44B@1239|Firmicutes,4HCES@91061|Bacilli,4GXUY@90964|Staphylococcaceae	91061|Bacilli	F	Adenosine/AMP deaminase	add	-	3.5.4.2,3.5.4.4	ko:K01488,ko:K02029,ko:K21053	ko00230,ko01100,ko05340,map00230,map01100,map05340	M00236	R01244,R01560,R02556	RC00477	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3	-	-	A_deaminase
k59_514467_1	1267535.KB906767_gene4612	2.25e-22	98.2	COG0577@1|root,COG0577@2|Bacteria	1267535.KB906767_gene4612|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_514467_2	234267.Acid_6524	1.75e-09	59.3	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_1737343_1	1192034.CAP_6261	3.9e-11	69.3	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,2YUPG@29|Myxococcales	28221|Deltaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_847438_1	861299.J421_6317	1.06e-24	108.0	COG0577@1|root,COG0577@2|Bacteria	861299.J421_6317|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_904194_2	1385935.N836_29975	2.09e-21	93.2	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	pelF	-	-	ko:K21011,ko:K21012	ko02025,map02025	-	-	-	ko00000,ko00001,ko01003	-	GT4	-	DUF3492,Glyco_trans_1_4,Glycos_transf_1
k59_1737353_1	1295642.H839_17463	1.69e-05	44.7	COG5336@1|root,COG5336@2|Bacteria,1VF5M@1239|Firmicutes,4HNYV@91061|Bacilli,1WGVJ@129337|Geobacillus	91061|Bacilli	S	Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter	-	-	-	-	-	-	-	-	-	-	-	-	ATPase_gene1
k59_1737353_2	880073.Calab_0240	1.73e-23	95.1	COG1664@1|root,COG1664@2|Bacteria,2NQ1N@2323|unclassified Bacteria	2|Bacteria	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
k59_514498_1	251221.35212995	1.09e-22	102.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_180574_1	1282876.BAOK01000001_gene2225	1.09e-88	266.0	COG4221@1|root,COG4221@2|Bacteria,1NTNU@1224|Proteobacteria,2TW2R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_847468_2	1267535.KB906767_gene4110	7.13e-21	92.8	COG3118@1|root,COG3118@2|Bacteria	2|Bacteria	O	belongs to the thioredoxin family	ybbN	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K05838	-	-	-	-	ko00000,ko03110	-	-	-	TPR_19,TPR_20,Thioredoxin
k59_1515108_1	1123325.JHUV01000015_gene245	3.97e-96	317.0	COG0587@1|root,COG0587@2|Bacteria,2G3PZ@200783|Aquificae	200783|Aquificae	L	TIGRFAM DNA polymerase III, alpha subunit	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,Intein_splicing,LAGLIDADG_3,PHP,tRNA_anti-codon
k59_1181607_1	1499967.BAYZ01000027_gene1815	2.13e-58	196.0	COG0407@1|root,COG0407@2|Bacteria	2|Bacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
k59_514519_1	465515.Mlut_16290	9.96e-10	59.3	COG0471@1|root,COG0471@2|Bacteria,2GVHZ@201174|Actinobacteria,1W8F3@1268|Micrococcaceae	201174|Actinobacteria	P	Sodium:sulfate symporter transmembrane region	sdcS	-	-	ko:K14445	-	-	-	-	ko00000,ko02000	2.A.47.1	-	-	Na_sulph_symp
k59_514519_2	1121033.AUCF01000016_gene5533	1.9e-69	216.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,2VEU2@28211|Alphaproteobacteria,2JRM1@204441|Rhodospirillales	204441|Rhodospirillales	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1348239_1	1123355.JHYO01000009_gene3078	4.96e-112	331.0	COG1840@1|root,COG1840@2|Bacteria,1MXZ8@1224|Proteobacteria,2TRY8@28211|Alphaproteobacteria,371GN@31993|Methylocystaceae	28211|Alphaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6
k59_959168_1	335283.Neut_1379	1.2e-21	99.0	COG0265@1|root,COG0308@1|root,COG2234@1|root,COG0265@2|Bacteria,COG0308@2|Bacteria,COG2234@2|Bacteria,1MV86@1224|Proteobacteria,2WEJA@28216|Betaproteobacteria,374P7@32003|Nitrosomonadales	28216|Betaproteobacteria	EO	pdz dhr glgf	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Peptidase_M1,Peptidase_M28
k59_1181623_1	378806.STAUR_1305	2.86e-100	300.0	COG0182@1|root,COG0182@2|Bacteria,1MUPM@1224|Proteobacteria,42MJ2@68525|delta/epsilon subdivisions,2WJQB@28221|Deltaproteobacteria,2YUJA@29|Myxococcales	28221|Deltaproteobacteria	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
k59_1015248_2	661478.OP10G_2021	1.04e-16	76.3	COG3682@1|root,COG3682@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
k59_1292581_1	1280681.AUJZ01000008_gene148	1.89e-07	54.3	COG1716@1|root,COG1716@2|Bacteria,1V550@1239|Firmicutes,24KXU@186801|Clostridia,4BX0R@830|Butyrivibrio	186801|Clostridia	T	Forkhead associated domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA
k59_1515126_1	443143.GM18_4034	3.98e-48	174.0	COG0457@1|root,COG0457@2|Bacteria,1MXSS@1224|Proteobacteria,42Z0Q@68525|delta/epsilon subdivisions,2WU0G@28221|Deltaproteobacteria,43T6R@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_737226_1	266265.Bxe_B1053	1.16e-85	275.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2VKEB@28216|Betaproteobacteria,1K5WS@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_959188_1	68194.JNXR01000029_gene2229	2.48e-09	59.7	COG3797@1|root,COG3797@2|Bacteria,2GPDB@201174|Actinobacteria	201174|Actinobacteria	I	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF1697
k59_1625800_1	909663.KI867149_gene3372	1.44e-22	91.7	COG2930@1|root,COG2930@2|Bacteria,1RAIB@1224|Proteobacteria,42S9D@68525|delta/epsilon subdivisions,2WN8Y@28221|Deltaproteobacteria,2MQJ7@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Las17-binding protein actin regulator	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
k59_1625800_2	65393.PCC7424_0474	4.4e-28	114.0	COG0530@1|root,COG0530@2|Bacteria,1G1Y9@1117|Cyanobacteria,3KHDA@43988|Cyanothece	1117|Cyanobacteria	P	Sodium/calcium exchanger protein	ecm27	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
k59_1238520_1	864051.BurJ1DRAFT_2685	2.62e-10	60.8	COG4117@1|root,COG4117@2|Bacteria,1R4HB@1224|Proteobacteria,2WFJG@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Cytochrome b/b6/petB	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
k59_1238520_2	864051.BurJ1DRAFT_2686	3.04e-68	211.0	COG2391@1|root,COG2391@2|Bacteria,1N3PQ@1224|Proteobacteria,2VXAQ@28216|Betaproteobacteria,1KP4P@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Sulphur transport	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
k59_737232_1	1157490.EL26_05100	9.82e-15	78.2	COG0724@1|root,COG2865@1|root,COG0724@2|Bacteria,COG2865@2|Bacteria,1TSPK@1239|Firmicutes,4HF0C@91061|Bacilli	91061|Bacilli	K	Putative ATP-dependent DNA helicase recG C-terminal	-	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AlbA_2,HATPase_c_4
k59_180630_1	383372.Rcas_1887	1.62e-51	184.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,2G65G@200795|Chloroflexi,374V3@32061|Chloroflexia	32061|Chloroflexia	I	PFAM Enoyl-CoA hydratase isomerase	-	-	1.1.1.35	ko:K07516	ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212	M00087	R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1,ECH_2
k59_569708_1	234267.Acid_2545	5.88e-25	108.0	COG0577@1|root,COG0577@2|Bacteria,3Y47F@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_136496_1	314278.NB231_11184	6.2e-83	265.0	COG0517@1|root,COG0538@1|root,COG0517@2|Bacteria,COG0538@2|Bacteria,1MW3J@1224|Proteobacteria,1RNMD@1236|Gammaproteobacteria,1WVYY@135613|Chromatiales	135613|Chromatiales	C	TIGRFAM isocitrate dehydrogenase, NADP-dependent	-	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	CBS,Iso_dh
k59_1694380_1	1122135.KB893134_gene3777	1.17e-48	174.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2TQMR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	ABC-type multidrug transport system ATPase and permease	msbA	-	-	ko:K02021,ko:K06147,ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_971646_1	861299.J421_2705	4.65e-25	100.0	COG4221@1|root,COG4221@2|Bacteria,1ZTPW@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_1195671_1	1111479.AXAR01000001_gene331	3.69e-87	269.0	COG0179@1|root,COG0179@2|Bacteria,1UY98@1239|Firmicutes,4HC89@91061|Bacilli,2788Y@186823|Alicyclobacillaceae	91061|Bacilli	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	3.7.1.2	ko:K16171	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R01364	RC00326,RC00446	ko00000,ko00001,ko00002,ko01000	-	-	-	FAA_hydrolase
k59_1528922_2	649638.Trad_2639	2.28e-11	62.8	COG0778@1|root,COG0778@2|Bacteria	2|Bacteria	C	coenzyme F420-1:gamma-L-glutamate ligase activity	tdsD	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
k59_194615_1	479434.Sthe_3271	4.03e-23	90.5	COG2002@1|root,COG2002@2|Bacteria	2|Bacteria	K	toxin-antitoxin pair type II binding	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin
k59_194615_2	547163.BN979_00725	4.21e-17	75.9	COG3945@1|root,COG3945@2|Bacteria,2I92G@201174|Actinobacteria,23938@1762|Mycobacteriaceae	201174|Actinobacteria	S	F420H(2)-dependent quinone reductase	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
k59_1084551_1	861299.J421_2767	3.95e-77	257.0	COG0085@1|root,COG0085@2|Bacteria,1ZSQH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_1639068_1	861299.J421_4297	4.5e-17	81.3	COG1020@1|root,COG1020@2|Bacteria	2|Bacteria	Q	D-alanine [D-alanyl carrier protein] ligase activity	-	-	2.3.1.20	ko:K00635	ko00561,ko01100,map00561,map01100	M00089	R02251	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1298,WES_acyltransf
k59_306530_1	945713.IALB_0020	3.43e-47	155.0	COG4747@1|root,COG4747@2|Bacteria	2|Bacteria	-	-	hom	-	1.1.1.3,1.1.1.399,1.1.1.95,1.3.1.12,4.3.1.19	ko:K00003,ko:K00058,ko:K01754,ko:K04517,ko:K04767	ko00260,ko00270,ko00290,ko00300,ko00400,ko00401,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00290,map00300,map00400,map00401,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00017,M00018,M00020,M00025,M00570	R00220,R00996,R01513,R01728,R01773,R01775	RC00031,RC00087,RC00125,RC00418,RC02600	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT,CBS,Homoserine_dh,Lactamase_B,NAD_binding_3
k59_1195686_1	1519464.HY22_01920	1.02e-11	68.9	COG0265@1|root,COG0265@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	MA20_17565	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
k59_1474012_1	1496688.ER33_02650	1.78e-05	52.4	COG0744@1|root,COG1716@1|root,COG0744@2|Bacteria,COG1716@2|Bacteria,1G25G@1117|Cyanobacteria,22TKY@167375|Cyanobium	1117|Cyanobacteria	MT	Forkhead associated domain	mrcB	-	-	-	-	-	-	-	-	-	-	-	FHA,Transgly,Transpeptidase,Yop-YscD_cpl
k59_528436_1	536019.Mesop_1809	1.02e-20	93.2	COG0154@1|root,COG0154@2|Bacteria,1MW3Z@1224|Proteobacteria,2TS56@28211|Alphaproteobacteria,43HUM@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	J	Belongs to the amidase family	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
k59_528436_2	1114970.PSF113_3073	0.000445	43.9	COG0583@1|root,COG0583@2|Bacteria,1MUNN@1224|Proteobacteria,1RMJ5@1236|Gammaproteobacteria,1YR47@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	K	Transcriptional regulator, LysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_919425_2	671143.DAMO_2712	7.87e-57	179.0	COG0838@1|root,COG0838@2|Bacteria,2NPTW@2323|unclassified Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoA	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0055114,GO:0098796,GO:1902494	1.6.5.3	ko:K00330,ko:K05574	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
k59_583234_1	246196.MSMEI_6411	4.46e-75	239.0	COG3335@1|root,COG3335@2|Bacteria,2GJQI@201174|Actinobacteria,234RT@1762|Mycobacteriaceae	201174|Actinobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_28,HTH_29,HTH_32
k59_1362565_1	1123251.ATWM01000010_gene2985	1.05e-30	124.0	COG1948@1|root,COG4880@2|Bacteria,2I8JU@201174|Actinobacteria,4FIJ4@85021|Intrasporangiaceae	201174|Actinobacteria	L	Beta propeller domain	-	-	-	-	-	-	-	-	-	-	-	-	Beta_propel
k59_1528943_1	686340.Metal_1563	5.4e-63	204.0	COG3039@1|root,COG3039@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_3
k59_696023_1	323259.Mhun_0191	4.5e-50	176.0	COG1132@1|root,arCOG02841@2157|Archaea,2XW9E@28890|Euryarchaeota	28890|Euryarchaeota	P	COG1132 ABC-type multidrug transport system, ATPase and permease components	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_1474032_1	1144310.PMI07_005437	4.09e-41	145.0	COG0235@1|root,COG0235@2|Bacteria,1RB5Z@1224|Proteobacteria,2U0PK@28211|Alphaproteobacteria,4BJMH@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Class II Aldolase and Adducin N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II
k59_919447_2	1128421.JAGA01000002_gene1057	2.62e-24	103.0	COG1721@1|root,COG1721@2|Bacteria	2|Bacteria	E	protein (some members contain a von Willebrand factor type A (vWA) domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,DUF58
k59_583252_1	644966.Tmar_1144	1.09e-53	185.0	COG1921@1|root,COG1921@2|Bacteria,1TQT8@1239|Firmicutes,2498U@186801|Clostridia,3WCCS@538999|Clostridiales incertae sedis	186801|Clostridia	J	Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis	selA	-	2.9.1.1	ko:K01042	ko00450,ko00970,map00450,map00970	-	R08219	RC01246	ko00000,ko00001,ko01000	-	-	-	Se-cys_synth_N,SelA
k59_528474_1	1123388.AQWU01000068_gene1064	2.27e-13	70.5	COG0223@1|root,COG0223@2|Bacteria,1WI0H@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
k59_528474_2	1121403.AUCV01000028_gene2449	2.35e-11	64.3	COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,42RFN@68525|delta/epsilon subdivisions,2WP25@28221|Deltaproteobacteria,2MJU0@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
k59_528476_1	1120985.AUMI01000016_gene1975	8.46e-05	49.3	COG1847@1|root,COG1847@2|Bacteria,1V3IN@1239|Firmicutes,4H41I@909932|Negativicutes	909932|Negativicutes	S	R3H domain protein	jag	-	-	ko:K06346	-	-	-	-	ko00000	-	-	-	Jag_N,KH_4,R3H
k59_919471_2	867845.KI911784_gene2385	2.78e-11	63.5	COG0484@1|root,COG0484@2|Bacteria,2G61V@200795|Chloroflexi,37696@32061|Chloroflexia	32061|Chloroflexia	O	PFAM heat shock protein DnaJ domain protein	-	-	-	ko:K05516	-	-	-	-	ko00000,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C
k59_1639126_1	314287.GB2207_05427	8.07e-93	289.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,1RMNZ@1236|Gammaproteobacteria,1J5CM@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_138661_1	189753.AXAS01000084_gene6056	2.67e-33	133.0	COG2114@1|root,COG3629@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3629@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,3JTQ7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,DZR,Guanylate_cyc,SAM_1,Trans_reg_C
k59_250073_1	477641.MODMU_2527	1.83e-78	242.0	COG0500@1|root,COG2226@2|Bacteria,2GNXF@201174|Actinobacteria	201174|Actinobacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
k59_138668_1	530564.Psta_2153	4.74e-23	101.0	COG1994@1|root,COG1994@2|Bacteria,2IZCZ@203682|Planctomycetes	203682|Planctomycetes	S	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
k59_974000_1	1267535.KB906767_gene347	2.86e-40	144.0	COG2159@1|root,COG2159@2|Bacteria,3Y6P0@57723|Acidobacteria	57723|Acidobacteria	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
k59_1417787_1	1313294.BPA_0077100	2.69e-13	73.2	COG0584@1|root,COG0584@2|Bacteria,2J9WQ@203691|Spirochaetes	203691|Spirochaetes	C	Glycerophosphoryl diester phosphodiesterase family	glpQ	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
k59_250086_2	222534.KB893766_gene2941	1.56e-57	197.0	COG1961@1|root,COG1961@2|Bacteria,2I8HV@201174|Actinobacteria	201174|Actinobacteria	L	COG1961 Site-specific recombinases, DNA invertase Pin homologs	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
k59_83736_1	710696.Intca_3543	0.000363	45.8	COG0599@1|root,COG0599@2|Bacteria,2IRPW@201174|Actinobacteria,4FJCM@85021|Intrasporangiaceae	201174|Actinobacteria	O	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
k59_974009_1	90814.KL370891_gene1898	4.72e-24	101.0	COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,1T02D@1236|Gammaproteobacteria,46181@72273|Thiotrichales	72273|Thiotrichales	F	Catalyzes the conversion of dihydroorotate to orotate	pyrD	-	1.3.1.14	ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
k59_974009_2	1415780.JPOG01000001_gene3061	7.63e-05	44.3	COG0284@1|root,COG0284@2|Bacteria,1MW2C@1224|Proteobacteria,1RNJR@1236|Gammaproteobacteria,1X4ID@135614|Xanthomonadales	135614|Xanthomonadales	F	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)	pyrF	GO:0003674,GO:0003824,GO:0004590,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
k59_83746_1	1120956.JHZK01000001_gene3372	1.93e-61	195.0	COG4665@1|root,COG4665@2|Bacteria,1RHBW@1224|Proteobacteria,2U4QB@28211|Alphaproteobacteria,1JPPQ@119043|Rhodobiaceae	28211|Alphaproteobacteria	Q	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
k59_361258_1	234267.Acid_4566	1.24e-30	125.0	COG0457@1|root,COG0457@2|Bacteria,3Y6HC@57723|Acidobacteria	57723|Acidobacteria	C	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1,TPR_16,TPR_4
k59_1084664_1	765914.ThisiDRAFT_0330	1.3e-58	199.0	COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,1RN3V@1236|Gammaproteobacteria,1WWTY@135613|Chromatiales	135613|Chromatiales	FP	Belongs to the GppA Ppx family	-	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
k59_1474103_1	180332.JTGN01000015_gene1162	0.000646	43.1	COG1847@1|root,COG1847@2|Bacteria,1V3IN@1239|Firmicutes,249EA@186801|Clostridia	186801|Clostridia	S	R3H domain protein	jag	-	-	ko:K06346	-	-	-	-	ko00000	-	-	-	Jag_N,KH_4,R3H
k59_1474103_2	1499967.BAYZ01000078_gene993	1.84e-16	80.1	COG0821@1|root,COG0821@2|Bacteria,2NNPV@2323|unclassified Bacteria	2|Bacteria	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009055,GO:0009058,GO:0009240,GO:0009987,GO:0016020,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0022900,GO:0030312,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046429,GO:0046490,GO:0046872,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0052592,GO:0055114,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901576	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b2515,iAPECO1_1312.APECO1_4009,iB21_1397.B21_02369,iBWG_1329.BWG_2279,iE2348C_1286.E2348C_2798,iEC55989_1330.EC55989_2800,iECABU_c1320.ECABU_c28200,iECBD_1354.ECBD_1171,iECB_1328.ECB_02407,iECDH10B_1368.ECDH10B_2681,iECDH1ME8569_1439.ECDH1ME8569_2442,iECDH1ME8569_1439.EcDH1_1153,iECD_1391.ECD_02407,iECED1_1282.ECED1_2946,iECH74115_1262.ECH74115_3740,iECIAI39_1322.ECIAI39_2716,iECNA114_1301.ECNA114_2593,iECO103_1326.ECO103_3032,iECO111_1330.ECO111_3239,iECO26_1355.ECO26_3562,iECOK1_1307.ECOK1_2863,iECP_1309.ECP_2520,iECS88_1305.ECS88_2691,iECSE_1348.ECSE_2801,iECSF_1327.ECSF_2359,iECSP_1301.ECSP_3455,iECW_1372.ECW_m2740,iECs_1301.ECs3377,iEKO11_1354.EKO11_1218,iETEC_1333.ETEC_2672,iEcDH1_1363.EcDH1_1153,iEcE24377_1341.EcE24377A_2799,iEcolC_1368.EcolC_1162,iHN637.CLJU_RS06430,iIT341.HP0625,iJN678.gcpE,iJO1366.b2515,iJR904.b2515,iLF82_1304.LF82_1130,iNRG857_1313.NRG857_12515,iUMN146_1321.UM146_04130,iUMNK88_1353.UMNK88_3165,iUTI89_1310.UTI89_C2836,iWFL_1372.ECW_m2740,iY75_1357.Y75_RS13130,iYL1228.KPN_02845,iZ_1308.Z3778,ic_1306.c3037	GcpE
k59_1140814_1	1207063.P24_14754	8.02e-67	223.0	COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,2TQQ8@28211|Alphaproteobacteria,2JQ4R@204441|Rhodospirillales	204441|Rhodospirillales	M	COG0744 Membrane carboxypeptidase (penicillin-binding protein)	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
k59_1639192_1	1229172.JQFA01000002_gene2860	1.26e-36	137.0	COG0654@1|root,COG0654@2|Bacteria,1G2G8@1117|Cyanobacteria,1HHEF@1150|Oscillatoriales	1117|Cyanobacteria	CH	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
k59_28257_1	404589.Anae109_2925	1.79e-31	127.0	COG1404@1|root,COG3940@1|root,COG1404@2|Bacteria,COG3940@2|Bacteria,1RCVP@1224|Proteobacteria	1224|Proteobacteria	O	pyrroloquinoline quinone binding	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta
k59_138743_1	864564.HMPREF0620_1265	6.2e-41	151.0	COG1129@1|root,COG1129@2|Bacteria,2GJ3F@201174|Actinobacteria,4CZ8Y@85004|Bifidobacteriales	201174|Actinobacteria	G	ATPases associated with a variety of cellular activities	rbsA	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
k59_1750790_1	981336.F944_03292	6.94e-63	215.0	COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,1RPTP@1236|Gammaproteobacteria,3NJ42@468|Moraxellaceae	1236|Gammaproteobacteria	H	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppc	GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0008964,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0072350	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	iSFV_1184.SFV_4025	PEPcase
k59_696157_1	204669.Acid345_4395	2.4e-21	98.6	COG0577@1|root,COG0577@2|Bacteria,3Y3Z1@57723|Acidobacteria,2JKRB@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_1639224_2	1279038.KB907346_gene3238	0.00018	41.2	COG0776@1|root,COG0776@2|Bacteria,1MZ7M@1224|Proteobacteria,2UBR5@28211|Alphaproteobacteria,2JT6X@204441|Rhodospirillales	204441|Rhodospirillales	K	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control	ihfB	-	-	ko:K05788	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
k59_1030501_1	314260.PB2503_03992	1.82e-08	56.6	COG1493@1|root,COG1493@2|Bacteria	2|Bacteria	T	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion	hprK	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K06023	-	-	-	-	ko00000,ko01000	-	-	-	Hpr_kinase_C,Hpr_kinase_N
k59_306695_2	6500.XP_005094129.1	2.63e-39	142.0	COG1804@1|root,KOG3957@2759|Eukaryota,38CWZ@33154|Opisthokonta,3BB7M@33208|Metazoa,3D0JC@33213|Bilateria	33208|Metazoa	I	succinate-hydroxymethylglutarate CoA-transferase activity	SUGCT	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0008410,GO:0016740,GO:0016782,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0047369	2.8.3.13	ko:K18703	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
k59_1030512_1	519989.ECTPHS_10114	4.34e-71	227.0	COG3146@1|root,COG3146@2|Bacteria,1MU35@1224|Proteobacteria,1RNWI@1236|Gammaproteobacteria,1WXHA@135613|Chromatiales	135613|Chromatiales	S	Peptidogalycan biosysnthesis/recognition	-	-	-	ko:K09919	-	-	-	-	ko00000	-	-	-	FemAB_like
k59_1195839_1	416591.Tlet_1392	2.48e-70	225.0	COG2403@1|root,COG2403@2|Bacteria,2GCJ5@200918|Thermotogae	200918|Thermotogae	S	cyclic 2,3-diphosphoglycerate synthetase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_583400_1	47763.JNZA01000033_gene3112	4.11e-102	313.0	COG1788@1|root,COG2057@1|root,COG1788@2|Bacteria,COG2057@2|Bacteria,2GMA1@201174|Actinobacteria	201174|Actinobacteria	I	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit	catJ	-	2.8.3.12	ko:K01040	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
k59_1474169_1	1123502.AQXD01000001_gene693	7.57e-07	49.7	COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,1RMAY@1236|Gammaproteobacteria,1X3E3@135614|Xanthomonadales	135614|Xanthomonadales	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_1474169_2	313606.M23134_01996	2.59e-52	177.0	COG0477@1|root,COG2814@2|Bacteria,4NEZT@976|Bacteroidetes,47M0X@768503|Cytophagia	976|Bacteroidetes	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_474579_1	1123072.AUDH01000001_gene3178	1.4e-37	140.0	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,2TRZ1@28211|Alphaproteobacteria,2JQ3U@204441|Rhodospirillales	204441|Rhodospirillales	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
k59_1474193_1	1049564.TevJSym_bb00050	5.36e-55	192.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,1S0WV@1236|Gammaproteobacteria,1J5KF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases	korA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
k59_1696881_1	1235797.C816_02778	6.07e-43	154.0	COG2301@1|root,COG2301@2|Bacteria,1TPDY@1239|Firmicutes,24AIH@186801|Clostridia,2N86P@216572|Oscillospiraceae	186801|Clostridia	G	HpcH/HpaI aldolase/citrate lyase family	-	-	4.1.3.34	ko:K01644	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS12480	HpcH_HpaI,Malate_synthase
k59_138804_1	1191523.MROS_1700	6.88e-19	85.1	COG0648@1|root,COG0648@2|Bacteria	2|Bacteria	L	deoxyribonuclease IV (phage-T4-induced) activity	nfo	GO:0000726,GO:0003674,GO:0003824,GO:0003906,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0008833,GO:0009987,GO:0016787,GO:0016788,GO:0016888,GO:0016893,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
k59_1307578_1	1125863.JAFN01000001_gene3575	1.05e-77	248.0	COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,42M4S@68525|delta/epsilon subdivisions,2WJQS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Belongs to the NiFe NiFeSe hydrogenase large subunit family	hyaL	-	1.12.99.6	ko:K06281	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
k59_860886_1	1177154.Y5S_01318	3.11e-65	201.0	2DSP5@1|root,33GW9@2|Bacteria,1NIK6@1224|Proteobacteria,1SISY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_321392_1	1194165.CAJF01000001_gene2024	1.54e-123	369.0	COG0624@1|root,COG0624@2|Bacteria,2GM84@201174|Actinobacteria,4FKZN@85023|Microbacteriaceae	201174|Actinobacteria	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
k59_988869_1	1479237.JMLY01000001_gene2086	1.39e-36	132.0	COG5549@1|root,COG5549@2|Bacteria,1RIJW@1224|Proteobacteria,1SIG8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Zinc-dependent metalloprotease	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M10
k59_152492_1	1173028.ANKO01000066_gene2450	1.36e-54	194.0	COG0841@1|root,COG0841@2|Bacteria,1G0C2@1117|Cyanobacteria,1H7C3@1150|Oscillatoriales	1117|Cyanobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_1488480_1	1430440.MGMSRv2_3923	4.29e-58	191.0	COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,2TT75@28211|Alphaproteobacteria,2JPAK@204441|Rhodospirillales	204441|Rhodospirillales	I	Glycerol-3-phosphate dehydrogenase	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
k59_1599376_1	981369.JQMJ01000004_gene2591	2.17e-48	177.0	COG3696@1|root,COG3696@2|Bacteria,2I53X@201174|Actinobacteria,2NFJQ@228398|Streptacidiphilus	201174|Actinobacteria	P	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_820272_1	1121939.L861_06870	4.01e-16	73.2	COG0713@1|root,COG0713@2|Bacteria,1N2E4@1224|Proteobacteria	1224|Proteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K05576	ko00190,ko01100,map00190,map01100	M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	-	-	-	Oxidored_q2
k59_1377116_1	1243664.CAVL020000031_gene519	4.18e-33	128.0	COG1820@1|root,COG1820@2|Bacteria,1TPFK@1239|Firmicutes,4HC6C@91061|Bacilli,1ZCM7@1386|Bacillus	91061|Bacilli	G	Belongs to the metallo-dependent hydrolases superfamily. NagA family	nagA	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005515,GO:0006040,GO:0006044,GO:0006046,GO:0008150,GO:0008152,GO:0008448,GO:0009056,GO:0016787,GO:0016810,GO:0016811,GO:0019213,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0046348,GO:0046872,GO:0046914,GO:0046983,GO:0071704,GO:1901071,GO:1901072,GO:1901135,GO:1901136,GO:1901575	3.5.1.25	ko:K01443	ko00520,ko01130,map00520,map01130	-	R02059	RC00166,RC00300	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
k59_651486_1	1001240.GY21_12500	2.53e-35	132.0	COG0451@1|root,COG0451@2|Bacteria,2IF2Z@201174|Actinobacteria,4FQ4C@85023|Microbacteriaceae	201174|Actinobacteria	GM	RmlD substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase,NAD_binding_10,RmlD_sub_bind
k59_1599396_1	953739.SVEN_1587	3.71e-69	234.0	COG0178@1|root,COG0178@2|Bacteria,2GJUV@201174|Actinobacteria	201174|Actinobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	GO:0000018,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0045910,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0071944,GO:0080090	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_1098903_1	375286.mma_2413	7.14e-46	153.0	COG2149@1|root,COG2149@2|Bacteria,1N8RW@1224|Proteobacteria,2VYKE@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Domain of unknown function (DUF202)	-	-	-	ko:K00389	-	-	-	-	ko00000	-	-	-	DUF202
k59_321461_1	1117319.PSPO_13317	1.3e-74	237.0	COG2021@1|root,COG2021@2|Bacteria,1MVJV@1224|Proteobacteria,1RQ2N@1236|Gammaproteobacteria,2PZWD@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	E	Belongs to the AB hydrolase superfamily. MetX family	metX	-	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
k59_1711769_1	861299.J421_2520	1.16e-27	113.0	COG0354@1|root,COG0354@2|Bacteria,1ZTMX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Glycine cleavage T-protein C-terminal barrel domain	-	-	-	ko:K06980	-	-	-	-	ko00000,ko03016	-	-	-	GCV_T,GCV_T_C
k59_41081_1	1246626.BleG1_3061	1.17e-06	55.5	COG0747@1|root,COG0747@2|Bacteria,1TQ0N@1239|Firmicutes,4HARF@91061|Bacilli,1ZC4E@1386|Bacillus	91061|Bacilli	E	COG0747 ABC-type dipeptide transport system, periplasmic component	oppA1	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_263043_1	1379270.AUXF01000002_gene1585	6.72e-92	299.0	COG0515@1|root,COG0515@2|Bacteria,1ZUMJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
k59_1377180_1	469383.Cwoe_5838	4.95e-38	145.0	COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,2GMFH@201174|Actinobacteria,4CPMF@84995|Rubrobacteria	84995|Rubrobacteria	L	DNA polymerase X	-	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_thumb,HHH_5,HHH_8,PHP
k59_321518_1	1294142.CINTURNW_4298	1.81e-13	73.2	COG0477@1|root,COG2814@2|Bacteria,1TQHD@1239|Firmicutes,24ANY@186801|Clostridia,36E4X@31979|Clostridiaceae	186801|Clostridia	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,MFS_3,Sugar_tr
k59_934659_1	326442.PSHAa0967	8.38e-25	108.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,2Q0U7@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	I	Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities	fadJ	GO:0003674,GO:0003824,GO:0003857,GO:0004300,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008692,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0016856,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575	1.1.1.35,4.2.1.17,5.1.2.3	ko:K01782	ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
k59_430977_1	1192034.CAP_0825	2.19e-79	263.0	COG2133@1|root,COG3055@1|root,COG2133@2|Bacteria,COG3055@2|Bacteria,1NRFC@1224|Proteobacteria,42YAV@68525|delta/epsilon subdivisions,2WTUF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1652161_1	1120983.KB894571_gene2089	3.1e-67	217.0	COG1638@1|root,COG1638@2|Bacteria,1NTFS@1224|Proteobacteria,2U1QM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	transport system periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_651549_1	385682.AFSL01000041_gene280	7.77e-21	91.3	COG2825@1|root,COG2825@2|Bacteria,4NH46@976|Bacteroidetes,2FQDW@200643|Bacteroidia,3XJZ6@558415|Marinilabiliaceae	976|Bacteroidetes	M	Outer membrane protein (OmpH-like)	ompH	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
k59_1098967_1	935567.JAES01000035_gene2328	5.38e-15	78.2	COG0515@1|root,COG0515@2|Bacteria,1MVEU@1224|Proteobacteria,1S0IU@1236|Gammaproteobacteria,1X4DU@135614|Xanthomonadales	135614|Xanthomonadales	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_10,TPR_12
k59_97690_1	1123242.JH636435_gene2582	1.63e-45	162.0	COG0138@1|root,COG0138@2|Bacteria,2IXB5@203682|Planctomycetes	203682|Planctomycetes	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
k59_1098974_1	1298867.AUES01000067_gene5125	4.01e-50	182.0	COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TTJ0@28211|Alphaproteobacteria,3JS5D@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HAMP,HATPase_c,HisKA,PAS_7,dCache_1
k59_431019_1	671143.DAMO_1596	1.62e-28	116.0	COG0508@1|root,COG0508@2|Bacteria,2NNYD@2323|unclassified Bacteria	2|Bacteria	C	2-oxoacid dehydrogenases acyltransferase (catalytic domain)	pdhC	-	1.2.4.1,2.3.1.12	ko:K00162,ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R02569,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02857,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_710512_1	644966.Tmar_0826	1.37e-53	175.0	COG0290@1|root,COG0290@2|Bacteria,1V1RC@1239|Firmicutes,24FUS@186801|Clostridia,3WCI3@538999|Clostridiales incertae sedis	186801|Clostridia	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	-	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
k59_710512_2	983545.Glaag_2549	6.91e-13	63.2	COG0291@1|root,COG0291@2|Bacteria,1N6V4@1224|Proteobacteria,1SCHI@1236|Gammaproteobacteria,468CG@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
k59_542279_1	1128421.JAGA01000002_gene90	3.54e-86	273.0	COG2766@1|root,COG2766@2|Bacteria	2|Bacteria	T	protein kinase activity	prkA	GO:0003674,GO:0003824,GO:0004672,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006995,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036211,GO:0042594,GO:0043170,GO:0043412,GO:0043562,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0140096,GO:1901564	-	ko:K07180	-	-	-	-	ko00000	-	-	-	AAA_PrkA,PrkA
k59_764219_1	1177154.Y5S_00335	1.86e-103	307.0	COG3000@1|root,COG3000@2|Bacteria,1R8P7@1224|Proteobacteria,1RRJW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	fatty acid hydroxylase	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
k59_820400_1	644966.Tmar_1634	1.46e-12	66.6	COG1335@1|root,COG1335@2|Bacteria,1VI3P@1239|Firmicutes,24RP8@186801|Clostridia	186801|Clostridia	Q	PFAM Isochorismatase	-	-	3.5.1.19	ko:K08281	ko00760,ko01100,map00760,map01100	-	R01268	RC00100	ko00000,ko00001,ko01000	-	-	-	Isochorismatase
k59_820400_2	330214.NIDE3777	1.54e-25	106.0	COG1488@1|root,COG1488@2|Bacteria	2|Bacteria	H	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	pncB	GO:0001666,GO:0003674,GO:0003824,GO:0004516,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009605,GO:0009607,GO:0009628,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016763,GO:0016874,GO:0016879,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0034355,GO:0034641,GO:0034654,GO:0036293,GO:0043094,GO:0043173,GO:0043207,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044403,GO:0044419,GO:0044464,GO:0046483,GO:0046496,GO:0047280,GO:0050896,GO:0051186,GO:0051188,GO:0051701,GO:0051704,GO:0051707,GO:0055086,GO:0070482,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0075136,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	iYO844.BSU31750	NAPRTase
k59_41168_2	861299.J421_4508	8.16e-37	138.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	3.2.1.14	ko:K01183	ko00520,ko01100,map00520,map01100	-	R01206,R02334	RC00467	ko00000,ko00001,ko01000	-	GH18	-	BNR_assoc_N,Big_2,DUF4465,Glyco_hydro_18,Glyco_hydro_9,LRR_5,PKD
k59_1267864_2	525904.Tter_1555	1.92e-05	48.9	COG1611@1|root,COG1611@2|Bacteria,2NP7M@2323|unclassified Bacteria	2|Bacteria	S	Possible lysine decarboxylase	yvdD_2	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
k59_1099008_1	1385935.N836_01310	4.31e-63	204.0	COG2801@1|root,COG2801@2|Bacteria,1G4NA@1117|Cyanobacteria,1HEWM@1150|Oscillatoriales	1117|Cyanobacteria	L	HTH-like domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve
k59_1377274_1	765911.Thivi_0644	5.81e-45	169.0	COG0642@1|root,COG0745@1|root,COG0784@1|root,COG0642@2|Bacteria,COG0745@2|Bacteria,COG0784@2|Bacteria,1NC9X@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
k59_710527_1	1123487.KB892840_gene35	1.95e-108	330.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,2VH14@28216|Betaproteobacteria,2KVAY@206389|Rhodocyclales	206389|Rhodocyclales	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
k59_41181_1	543632.JOJL01000051_gene6554	7.32e-26	107.0	COG0604@1|root,COG0604@2|Bacteria,2GN47@201174|Actinobacteria,4D8ZC@85008|Micromonosporales	201174|Actinobacteria	C	Zinc-binding dehydrogenase	qor	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
k59_1711886_1	985665.HPL003_25205	9.29e-30	120.0	COG0770@1|root,COG0770@2|Bacteria,1VT78@1239|Firmicutes,4HACR@91061|Bacilli,26S7E@186822|Paenibacillaceae	91061|Bacilli	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_97744_1	378806.STAUR_1723	4.33e-42	152.0	COG2273@1|root,COG2273@2|Bacteria,1R91A@1224|Proteobacteria,43AHP@68525|delta/epsilon subdivisions,2X5XV@28221|Deltaproteobacteria,2Z37I@29|Myxococcales	28221|Deltaproteobacteria	G	Beta-glucan synthesis-associated protein (SKN1)	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_16
k59_1322564_1	153721.MYP_1725	1.62e-44	162.0	COG1132@1|root,COG1132@2|Bacteria,4NHI1@976|Bacteroidetes,47JJQ@768503|Cytophagia	976|Bacteroidetes	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_597239_1	570952.ATVH01000016_gene2525	2.13e-59	193.0	COG1192@1|root,COG1192@2|Bacteria,1MVKR@1224|Proteobacteria,2TRZY@28211|Alphaproteobacteria,2JP8S@204441|Rhodospirillales	204441|Rhodospirillales	D	COG1192 ATPases involved in chromosome partitioning	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	MipZ
k59_431100_1	1121920.AUAU01000001_gene2206	1.94e-34	129.0	COG0500@1|root,COG2226@2|Bacteria,3Y4HC@57723|Acidobacteria	2|Bacteria	Q	Hypothetical methyltransferase	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
k59_1045395_1	1280950.HJO_03640	1.44e-16	84.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,43WK1@69657|Hyphomonadaceae	28211|Alphaproteobacteria	C	acyl-CoA transferases carnitine dehydratase	-	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
k59_651646_1	1278073.MYSTI_02176	2.3e-30	124.0	COG0577@1|root,COG0577@2|Bacteria,1NREW@1224|Proteobacteria	1224|Proteobacteria	V	COG0577 ABC-type antimicrobial peptide transport system permease component	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_152726_1	926550.CLDAP_19470	1.98e-18	91.3	COG0457@1|root,COG3629@1|root,COG3903@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,COG3903@2|Bacteria,2G7SC@200795|Chloroflexi	200795|Chloroflexi	K	intracellular signal transduction	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,TPR_12
k59_1432048_1	861299.J421_5649	4.99e-80	254.0	COG5434@1|root,COG5434@2|Bacteria	2|Bacteria	M	polygalacturonase activity	-	-	3.2.1.15	ko:K01184	ko00040,ko01100,map00040,map01100	M00081	R01982,R02360	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Beta_helix,Glyco_hydro_28,Pectate_lyase_3
k59_1322618_1	251221.35212347	6.96e-60	200.0	COG2244@1|root,COG2244@2|Bacteria,1G3GP@1117|Cyanobacteria	1117|Cyanobacteria	S	Membrane protein involved in the export of O-antigen and teichoic acid	-	-	-	ko:K03328	-	-	-	-	ko00000	2.A.66.2	-	-	Polysacc_synt_3,Polysacc_synt_C
k59_1045415_1	246196.MSMEI_4238	2.08e-06	55.1	COG2230@1|root,COG2230@2|Bacteria,2H060@201174|Actinobacteria,235MW@1762|Mycobacteriaceae	201174|Actinobacteria	M	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
k59_207022_1	383372.Rcas_3859	3.44e-99	296.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5,DDE_Tnp_1
k59_1267955_1	1336249.JADW01000018_gene162	1.24e-57	189.0	COG2313@1|root,COG2313@2|Bacteria,1MUQU@1224|Proteobacteria,2TUKT@28211|Alphaproteobacteria,4B8FZ@82115|Rhizobiaceae	28211|Alphaproteobacteria	Q	Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway	psuG	-	4.2.1.70	ko:K16329	ko00240,map00240	-	R01055	RC00432,RC00433	ko00000,ko00001,ko01000	-	-	-	Indigoidine_A
k59_1432078_1	324602.Caur_1107	7.86e-71	223.0	COG1175@1|root,COG1175@2|Bacteria,2G8BY@200795|Chloroflexi,3773P@32061|Chloroflexia	2|Bacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	lacF	-	-	ko:K02025,ko:K05814,ko:K10118,ko:K10233,ko:K15771,ko:K17245	ko02010,map02010	M00196,M00198,M00201,M00207,M00491,M00601	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.16,3.A.1.1.2,3.A.1.1.28,3.A.1.1.3,3.A.1.1.32,3.A.1.1.40,3.A.1.1.8	-	-	BPD_transp_1
k59_875601_2	1463825.JNXC01000023_gene4961	1.51e-19	90.5	COG0559@1|root,COG0559@2|Bacteria,2HDZ9@201174|Actinobacteria,4DZD5@85010|Pseudonocardiales	201174|Actinobacteria	U	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_1763784_2	264462.Bd3406	1.18e-75	228.0	COG1558@1|root,COG1558@2|Bacteria,1RHI3@1224|Proteobacteria,42TPI@68525|delta/epsilon subdivisions,2MT0U@213481|Bdellovibrionales,2WP1C@28221|Deltaproteobacteria	213481|Bdellovibrionales	N	Belongs to the flagella basal body rod proteins family	flgC	-	-	ko:K02388	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
k59_1599619_1	313606.M23134_04933	5.2e-53	188.0	COG0841@1|root,COG0841@2|Bacteria,4NDZG@976|Bacteroidetes,47N6C@768503|Cytophagia	976|Bacteroidetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_875651_2	335543.Sfum_0987	4.98e-21	87.4	COG0640@1|root,COG0640@2|Bacteria,1RGYC@1224|Proteobacteria,42X86@68525|delta/epsilon subdivisions,2WSJA@28221|Deltaproteobacteria,2MSBA@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
k59_820565_1	1519464.HY22_13665	3.4e-85	263.0	COG1158@1|root,COG1158@2|Bacteria,1FDA7@1090|Chlorobi	1090|Chlorobi	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
k59_263307_1	314262.MED193_05879	3.69e-43	151.0	COG2135@1|root,COG2135@2|Bacteria,1RER4@1224|Proteobacteria,2U0W2@28211|Alphaproteobacteria,2P1HE@2433|Roseobacter	28211|Alphaproteobacteria	S	Belongs to the SOS response-associated peptidase family	MA20_42060	-	-	-	-	-	-	-	-	-	-	-	SRAP
k59_321771_1	365046.Rta_04410	0.000981	48.5	COG0642@1|root,COG0745@1|root,COG1340@1|root,COG1352@1|root,COG2201@1|root,COG3829@1|root,COG0745@2|Bacteria,COG1340@2|Bacteria,COG1352@2|Bacteria,COG2201@2|Bacteria,COG2205@2|Bacteria,COG3829@2|Bacteria,1NRP8@1224|Proteobacteria,2VZTF@28216|Betaproteobacteria,4AC39@80864|Comamonadaceae	28216|Betaproteobacteria	T	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	-	-	2.1.1.80,3.1.1.61	ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,CheR,CheR_N,HATPase_c,HisKA,PAS,PAS_10,PAS_4,PAS_9,Response_reg
k59_712395_1	247490.KSU1_C0490	3.75e-40	150.0	COG0038@1|root,COG0517@1|root,COG0038@2|Bacteria,COG0517@2|Bacteria,2IY1G@203682|Planctomycetes	203682|Planctomycetes	P	COG0038 Chloride channel protein EriC	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,Voltage_CLC
k59_543864_1	1382306.JNIM01000001_gene2207	7.26e-83	261.0	COG0446@1|root,COG0446@2|Bacteria,2G6GM@200795|Chloroflexi	200795|Chloroflexi	S	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_543864_2	589924.Ferp_2460	1.15e-29	107.0	COG0425@1|root,arCOG02062@2157|Archaea,2XZUG@28890|Euryarchaeota,246G4@183980|Archaeoglobi	183980|Archaeoglobi	O	Sulfurtransferase TusA	-	-	-	-	-	-	-	-	-	-	-	-	TusA
k59_1226427_2	1123070.KB899252_gene821	1.56e-19	87.4	COG0738@1|root,COG0738@2|Bacteria,46VVQ@74201|Verrucomicrobia,2IU7A@203494|Verrucomicrobiae	203494|Verrucomicrobiae	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1115128_1	521045.Kole_2088	4.03e-23	99.8	COG1001@1|root,COG1001@2|Bacteria,2GC3B@200918|Thermotogae	200918|Thermotogae	F	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family	ade	-	3.5.4.2	ko:K01486	ko00230,ko01100,map00230,map01100	-	R01244	RC00477	ko00000,ko00001,ko01000	-	-	-	Adenine_deam_C,Amidohydro_1
k59_1115128_2	1123372.AUIT01000004_gene1185	6.22e-47	157.0	COG0634@1|root,COG0634@2|Bacteria,2GH72@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	-	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
k59_1392779_1	207954.MED92_15113	1.27e-109	335.0	COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,1RN6Z@1236|Gammaproteobacteria,1XIGC@135619|Oceanospirillales	135619|Oceanospirillales	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
k59_614576_1	1121904.ARBP01000022_gene3483	5.85e-35	135.0	COG3537@1|root,COG3537@2|Bacteria,4NDYB@976|Bacteroidetes,47KZ5@768503|Cytophagia	976|Bacteroidetes	G	PFAM Glycosyl Hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_92
k59_614576_2	1356852.N008_06530	0.000552	46.2	COG0501@1|root,COG0501@2|Bacteria	2|Bacteria	O	metalloendopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
k59_1448672_1	1151292.QEW_3225	1.85e-14	68.9	COG2020@1|root,COG2020@2|Bacteria,1UXZ3@1239|Firmicutes,24AR1@186801|Clostridia	186801|Clostridia	O	Isoprenylcysteine carboxyl methyltransferase (ICMT) family	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
k59_558875_1	926569.ANT_12430	7.98e-65	213.0	COG0165@1|root,COG0165@2|Bacteria,2G616@200795|Chloroflexi	200795|Chloroflexi	E	argininosuccinate lyase	argH	GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
k59_892728_1	935261.JAGL01000020_gene407	4.14e-83	251.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2TSA6@28211|Alphaproteobacteria,43JZ7@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	ATPases associated with a variety of cellular activities	MA20_22615	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
k59_892728_2	794846.AJQU01000070_gene1732	5.03e-13	67.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2TUQB@28211|Alphaproteobacteria,4BA11@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	COG0411 ABC-type branched-chain amino acid transport systems, ATPase component	MA20_22610	GO:0003333,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0015711,GO:0015803,GO:0015804,GO:0015807,GO:0015808,GO:0015818,GO:0015829,GO:0015849,GO:0015893,GO:0032328,GO:0034220,GO:0042221,GO:0042493,GO:0042940,GO:0042941,GO:0043090,GO:0046942,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098739,GO:1902475,GO:1903714,GO:1903785,GO:1903805,GO:1903806,GO:1903825,GO:1905039	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
k59_948239_1	391625.PPSIR1_03943	1.05e-45	160.0	COG1816@1|root,COG1816@2|Bacteria,1MWBV@1224|Proteobacteria,42UJZ@68525|delta/epsilon subdivisions,2WQCC@28221|Deltaproteobacteria,2YV77@29|Myxococcales	28221|Deltaproteobacteria	F	adenosine deaminase	add	-	3.5.4.4	ko:K01488	ko00230,ko01100,ko05340,map00230,map01100,map05340	-	R01560,R02556	RC00477	ko00000,ko00001,ko01000	-	-	-	A_deaminase
k59_225473_1	1453501.JELR01000001_gene1941	9.86e-59	204.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,1RMAP@1236|Gammaproteobacteria,464XP@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
k59_1170576_1	1121878.AUGL01000021_gene2816	6.8e-45	157.0	COG0760@1|root,COG0760@2|Bacteria,1R4ZR@1224|Proteobacteria,1SEDW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	PPIC-type PPIASE domain	-	-	-	-	-	-	-	-	-	-	-	-	Rotamase_2
k59_1337386_1	414684.RC1_2487	2.45e-65	215.0	COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,2TQPV@28211|Alphaproteobacteria,2JR06@204441|Rhodospirillales	204441|Rhodospirillales	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
k59_614611_2	1034347.CAHJ01000012_gene2392	5.93e-18	85.5	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	tlpA	-	-	-	-	-	-	-	-	-	-	-	Redoxin,Thioredoxin_8
k59_58753_1	1121129.KB903367_gene2689	3.89e-17	85.1	COG0526@1|root,COG0526@2|Bacteria,4NEX3@976|Bacteroidetes,2FN8N@200643|Bacteroidia	976|Bacteroidetes	CO	AhpC Tsa family	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,DUF4369,Redoxin,Thioredoxin_8
k59_1448714_1	746697.Aeqsu_2969	4.84e-40	140.0	COG3652@1|root,COG3652@2|Bacteria,4NP09@976|Bacteroidetes,1I2DD@117743|Flavobacteriia	976|Bacteroidetes	S	Domain of unknown function (DUF4142)	-	-	-	ko:K08995	-	-	-	-	ko00000	-	-	-	DUF4142
k59_1615265_2	29540.C481_01957	2.04e-76	251.0	COG2217@1|root,arCOG01576@2157|Archaea,2XT3T@28890|Euryarchaeota,23S6X@183963|Halobacteria	183963|Halobacteria	P	copper-translocating P-type ATPase	-	-	3.6.3.4	ko:K01533	-	-	R00086	RC00002	ko00000,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase
k59_1392829_1	1408424.JHYI01000017_gene2935	1.37e-09	61.6	COG3221@1|root,COG3221@2|Bacteria,1TR0H@1239|Firmicutes,4HBJQ@91061|Bacilli,1ZE0C@1386|Bacillus	91061|Bacilli	P	Phosphonate ABC transporter	phnD	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	Phosphonate-bd
k59_1115188_1	395493.BegalDRAFT_1174	1.24e-05	52.0	COG3023@1|root,COG3023@2|Bacteria,1RDHU@1224|Proteobacteria,1RMDN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	N-acetylmuramoyl-L-alanine amidase	amiD	GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008745,GO:0009056,GO:0009057,GO:0009253,GO:0009254,GO:0009392,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0019867,GO:0030203,GO:0043167,GO:0043169,GO:0043170,GO:0046872,GO:0046914,GO:0061783,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575	3.4.16.4,3.5.1.28	ko:K01447,ko:K11066,ko:K21469	ko00550,map00550	-	R04112	RC00064,RC00141	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Amidase_2,PG_binding_1
k59_836960_1	402881.Plav_1377	1.91e-221	617.0	COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,2TTGS@28211|Alphaproteobacteria,1JNAY@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	Arginosuccinate synthase	argG	GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
k59_1226508_1	1333998.M2A_2216	3.08e-70	221.0	COG0559@1|root,COG0559@2|Bacteria,1MVND@1224|Proteobacteria,2TRMA@28211|Alphaproteobacteria,4BREC@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_281155_1	102125.Xen7305DRAFT_00043960	2.39e-70	228.0	COG5361@1|root,COG5361@2|Bacteria,1GIK1@1117|Cyanobacteria,3VMQJ@52604|Pleurocapsales	1117|Cyanobacteria	S	Protein of unknown function (DUF1214)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_1448724_1	653733.Selin_0567	2.14e-39	148.0	COG0348@1|root,COG1622@1|root,COG0348@2|Bacteria,COG1622@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	vnfA	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	Cupredoxin_1,Fer4_5,Sigma54_activat,cNMP_binding
k59_1337415_1	215803.DB30_7808	2.6e-08	56.2	COG1651@1|root,COG1651@2|Bacteria,1MX2T@1224|Proteobacteria,42S4E@68525|delta/epsilon subdivisions,2WNJ8@28221|Deltaproteobacteria,2YXBC@29|Myxococcales	28221|Deltaproteobacteria	O	Thioredoxin	-	-	-	-	-	-	-	-	-	-	-	-	SurA_N_3,Thioredoxin_4
k59_1337415_2	338963.Pcar_0729	4.3e-12	64.7	COG0203@1|root,COG0203@2|Bacteria,1RCWN@1224|Proteobacteria,42SBD@68525|delta/epsilon subdivisions,2WP9P@28221|Deltaproteobacteria,43V08@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	PFAM ribosomal protein L17	rplQ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
k59_1170615_1	1131269.AQVV01000003_gene709	6.05e-19	90.9	COG0589@1|root,COG1592@1|root,COG0589@2|Bacteria,COG1592@2|Bacteria	2|Bacteria	C	Rubrerythrin	usp1	-	1.6.3.4	ko:K22405	-	-	-	-	ko00000,ko01000	-	-	-	DinB_2,Rubrerythrin,Usp
k59_114311_1	1129374.AJE_08220	4.19e-106	320.0	COG0399@1|root,COG0399@2|Bacteria,1MUMJ@1224|Proteobacteria,1RSDY@1236|Gammaproteobacteria,469FZ@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	Transposase zinc-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
k59_58770_1	570967.JMLV01000010_gene1193	2.18e-93	281.0	COG1028@1|root,COG1028@2|Bacteria,1MUUV@1224|Proteobacteria,2TR0A@28211|Alphaproteobacteria,2JPRF@204441|Rhodospirillales	204441|Rhodospirillales	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
k59_1170616_1	323848.Nmul_A0309	2.05e-89	270.0	COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,2VJBW@28216|Betaproteobacteria,371MG@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
k59_558928_1	1297570.MESS4_820056	1.56e-119	348.0	COG1079@1|root,COG1079@2|Bacteria,1MVDQ@1224|Proteobacteria,2TSGJ@28211|Alphaproteobacteria,43NN4@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Branched-chain amino acid transport system / permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
k59_892783_1	289376.THEYE_A0880	5.99e-33	119.0	COG1463@1|root,COG1463@2|Bacteria,3J191@40117|Nitrospirae	40117|Nitrospirae	Q	MlaD protein	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
k59_892783_2	247490.KSU1_C1261	2.2e-09	59.7	COG2854@1|root,COG2854@2|Bacteria,2J2VT@203682|Planctomycetes	203682|Planctomycetes	Q	MlaC protein	-	-	-	-	-	-	-	-	-	-	-	-	MlaC
k59_1559761_1	690585.JNNU01000016_gene2573	5e-22	102.0	COG0457@1|root,COG3629@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4B9US@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,Guanylate_cyc,TPR_14,TPR_16
k59_836973_1	218284.CCDN010000005_gene3402	3.66e-42	154.0	COG2206@1|root,COG2206@2|Bacteria,1TQIM@1239|Firmicutes,4HBV6@91061|Bacilli,1ZCMY@1386|Bacillus	91061|Bacilli	T	HD domain	cnpD3	-	-	-	-	-	-	-	-	-	-	-	HD,HD_5
k59_392340_1	930166.CD58_15765	7.15e-28	118.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria	1224|Proteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE4,EAL,GGDEF,PAS,PAS_4,PAS_9
k59_1170635_1	134676.ACPL_5170	1.49e-37	140.0	COG1960@1|root,COG1960@2|Bacteria,2GJHM@201174|Actinobacteria,4D9D4@85008|Micromonosporales	201174|Actinobacteria	I	acyl-CoA dehydrogenase	aidB	-	-	ko:K09456	-	-	-	-	ko00000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M
k59_503584_1	926569.ANT_23420	6.75e-64	207.0	COG0812@1|root,COG0812@2|Bacteria,2G6H3@200795|Chloroflexi	200795|Chloroflexi	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
k59_1170649_1	671143.DAMO_2710	2.58e-62	201.0	COG0649@1|root,COG0649@2|Bacteria,2NNXB@2323|unclassified Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	-	1.6.5.3	ko:K00333,ko:K13378	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
k59_503591_1	639283.Snov_1888	4.46e-76	239.0	COG1472@1|root,COG1472@2|Bacteria,1MVAJ@1224|Proteobacteria,2TRJK@28211|Alphaproteobacteria,3EZ0H@335928|Xanthobacteraceae	28211|Alphaproteobacteria	G	Glycosyl hydrolase family 3 N terminal domain	nagZ	-	3.2.1.21,3.2.1.52	ko:K01207,ko:K05349	ko00460,ko00500,ko00520,ko00531,ko00940,ko01100,ko01110,ko01501,map00460,map00500,map00520,map00531,map00940,map01100,map01110,map01501	M00628	R00022,R00026,R02558,R02887,R02985,R03527,R04949,R04998,R05963,R07809,R07810,R10035,R10039,R10040,R10831	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko00002,ko01000	-	GH3	-	Glyco_hydro_3
k59_392367_1	694427.Palpr_1342	7.46e-21	94.0	COG3507@1|root,COG3507@2|Bacteria,4NHV4@976|Bacteroidetes,2FSJ1@200643|Bacteroidia,22Y0Z@171551|Porphyromonadaceae	976|Bacteroidetes	G	Glycosyl hydrolases family 43	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_43
k59_114357_1	1218075.BAYA01000018_gene4746	7.04e-63	204.0	COG1893@1|root,COG1893@2|Bacteria,1P0AW@1224|Proteobacteria,2VKA6@28216|Betaproteobacteria,1KFDC@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
k59_1059404_1	342113.DM82_3991	3.7e-58	196.0	COG2072@1|root,COG2072@2|Bacteria,1MUQH@1224|Proteobacteria,2VH66@28216|Betaproteobacteria,1K7DJ@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Flavin-binding monooxygenase-like	-	-	-	-	-	-	-	-	-	-	-	-	FMO-like
k59_1615321_1	546274.EIKCOROL_00935	9.69e-23	102.0	COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,2VH37@28216|Betaproteobacteria,2KPZB@206351|Neisseriales	206351|Neisseriales	C	FAD dependent oxidoreductase	-	-	1.5.5.1	ko:K00311	-	-	-	-	ko00000,ko01000	-	-	-	ETF_QO,FAD_binding_2,NAD_binding_8
k59_1115250_1	926569.ANT_12290	1.69e-98	298.0	COG3464@1|root,COG3464@2|Bacteria,2G9B1@200795|Chloroflexi	200795|Chloroflexi	L	Transposase IS66 family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66
k59_281214_1	156889.Mmc1_1432	1.27e-39	149.0	COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,2TRFV@28211|Alphaproteobacteria	1224|Proteobacteria	G	Belongs to the pyruvate kinase family	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Fer4_9,PK,PK_C
k59_1226575_1	443143.GM18_3943	9.19e-109	334.0	COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,42MZ4@68525|delta/epsilon subdivisions,2WJPB@28221|Deltaproteobacteria,43T5J@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity	katG	GO:0000302,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016684,GO:0016999,GO:0017001,GO:0017144,GO:0020037,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042542,GO:0042737,GO:0042743,GO:0042744,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046906,GO:0048037,GO:0050896,GO:0051186,GO:0051187,GO:0051716,GO:0055114,GO:0070301,GO:0070887,GO:0071236,GO:0072593,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901363,GO:1901700,GO:1901701,GO:1990748	1.11.1.21	ko:K03782	ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110	-	R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906	RC00034,RC00213,RC00767,RC02141	ko00000,ko00001,ko01000	-	-	-	peroxidase
k59_503608_1	1411123.JQNH01000001_gene1380	8.24e-69	232.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2TQK9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_1281917_1	498761.HM1_1037	1.41e-66	228.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1TQ0B@1239|Firmicutes,248IB@186801|Clostridia	186801|Clostridia	E	'glutamate synthase	gltB	-	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_225582_1	1869.MB27_35120	1.76e-62	214.0	COG0474@1|root,COG0474@2|Bacteria,2GJJC@201174|Actinobacteria,4DBNX@85008|Micromonosporales	201174|Actinobacteria	P	E1-E2 ATPase	-	-	3.6.3.8	ko:K01537,ko:K12953	-	-	-	-	ko00000,ko01000	3.A.3,3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
k59_503622_1	68219.JNXI01000010_gene5607	3.49e-65	210.0	COG3285@1|root,COG3285@2|Bacteria,2GJPX@201174|Actinobacteria	201174|Actinobacteria	L	DNA polymerase LigD polymerase domain	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_primase_S
k59_1226610_1	1184609.KILIM_014_00060	1.03e-34	136.0	COG1502@1|root,COG1502@2|Bacteria,2GM0P@201174|Actinobacteria,4F61B@85018|Dermatophilaceae	201174|Actinobacteria	I	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	cls	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2,PLDc_N
k59_225604_1	313596.RB2501_03955	4.15e-80	248.0	COG3970@1|root,COG3970@2|Bacteria,4NGTH@976|Bacteroidetes,1I0WA@117743|Flavobacteriia	976|Bacteroidetes	S	Fumarylacetoacetate (FAA) hydrolase family	-	-	4.2.1.141	ko:K14259	ko00040,map00040	-	R09186	RC00429	ko00000,ko00001,ko01000	-	-	-	FAA_hydrolase
k59_225611_1	156578.ATW7_14661	4.43e-13	70.5	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,Response_reg
k59_225611_2	742726.HMPREF9448_00039	3.17e-15	77.8	COG0745@1|root,COG3292@1|root,COG5002@1|root,COG0745@2|Bacteria,COG3292@2|Bacteria,COG5002@2|Bacteria,4P0IA@976|Bacteroidetes,2FWSR@200643|Bacteroidia,231P1@171551|Porphyromonadaceae	976|Bacteroidetes	T	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y
k59_503663_1	856793.MICA_2025	2.94e-75	250.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,4BRPD@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	V	AcrB/AcrD/AcrF family	MA20_26850	-	-	ko:K18299,ko:K18902	-	M00641,M00698	-	-	ko00000,ko00002,ko01504,ko02000	2.A.6.2,2.A.6.2.16	-	-	ACR_tran
k59_781583_1	273057.SSO2130	2.74e-79	246.0	COG1013@1|root,arCOG01601@2157|Archaea,2XPVE@28889|Crenarchaeota	28889|Crenarchaeota	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
k59_1059472_1	1499967.BAYZ01000028_gene1276	2.86e-34	125.0	2CA4A@1|root,32RQK@2|Bacteria,2NPW6@2323|unclassified Bacteria	2|Bacteria	S	Domain of unknown function (DUF4416)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4416
k59_1226656_1	702113.PP1Y_AT36339	3.31e-17	83.2	COG1387@1|root,COG1387@2|Bacteria,1R4SE@1224|Proteobacteria,2U0Q5@28211|Alphaproteobacteria,2K2BP@204457|Sphingomonadales	204457|Sphingomonadales	E	Histidinol phosphatase and related hydrolases of the PHP family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_336678_1	767817.Desgi_1716	2.25e-64	211.0	COG0438@1|root,COG0438@2|Bacteria,1TS4X@1239|Firmicutes,24BYU@186801|Clostridia,261FH@186807|Peptococcaceae	186801|Clostridia	M	Glycosyl transferases group 1	-	-	2.4.1.245	ko:K13057	ko00500,ko01100,map00500,map01100	-	R08946,R10525,R11306	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000	-	GT4	-	Glycos_transf_1
k59_336681_1	349521.HCH_06289	2.04e-69	224.0	COG0006@1|root,COG0006@2|Bacteria,1MWUT@1224|Proteobacteria,1RZSD@1236|Gammaproteobacteria,1XNGP@135619|Oceanospirillales	135619|Oceanospirillales	E	Creatinase/Prolidase N-terminal domain	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016812,GO:0019752,GO:0032787,GO:0042399,GO:0042400,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046395,GO:0046483,GO:0046700,GO:0071704,GO:0072329,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575	3.4.13.9,3.5.4.44	ko:K01271,ko:K15783	ko00260,ko01100,map00260,map01100	-	R09800	RC02661	ko00000,ko00001,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
k59_281305_1	105559.Nwat_3075	2.62e-22	100.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,1RQ8B@1236|Gammaproteobacteria,1WXE6@135613|Chromatiales	135613|Chromatiales	T	signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS_4,PAS_8
k59_781615_1	224914.BMEI0553	1.23e-112	340.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2TS7G@28211|Alphaproteobacteria,1J2QN@118882|Brucellaceae	28211|Alphaproteobacteria	S	ABC transporter	chvD	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_Xtn
k59_1283127_1	414684.RC1_1521	5.13e-48	165.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,2JQKF@204441|Rhodospirillales	204441|Rhodospirillales	C	III protein, CoA-transferase family	-	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
k59_615902_3	290397.Adeh_0985	1.27e-11	65.9	COG4784@1|root,COG4784@2|Bacteria,1QTT7@1224|Proteobacteria,43C89@68525|delta/epsilon subdivisions,2X7IN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
k59_1561031_1	866895.HBHAL_1081	1.48e-20	96.3	COG0001@1|root,COG0001@2|Bacteria,1TRD7@1239|Firmicutes,4HA12@91061|Bacilli,3NEQX@45667|Halobacillus	91061|Bacilli	H	Aminotransferase class-III	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_838253_1	1379698.RBG1_1C00001G0172	1.7e-43	152.0	COG1825@1|root,COG1825@2|Bacteria,2NPVU@2323|unclassified Bacteria	2|Bacteria	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
k59_1338749_1	526225.Gobs_1069	1.54e-30	124.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,2GMN4@201174|Actinobacteria,4ES6Q@85013|Frankiales	201174|Actinobacteria	GT	PEP-utilising enzyme, mobile domain	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
k59_615925_1	700598.Niako_0406	5.46e-09	61.6	COG2866@1|root,COG2866@2|Bacteria,4NEJA@976|Bacteroidetes,1IQWN@117747|Sphingobacteriia	976|Bacteroidetes	E	PFAM Zinc carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux,Peptidase_M14
k59_337815_1	1198232.CYCME_1250	3.61e-09	59.3	COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,1RNYW@1236|Gammaproteobacteria,4609T@72273|Thiotrichales	72273|Thiotrichales	OU	signal peptide peptidase SppA, 36K type	sppA	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
k59_1573264_1	420324.KI912027_gene316	4.19e-113	340.0	COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,2TS6X@28211|Alphaproteobacteria,1JX9I@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Putative transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
k59_1406638_1	449447.MAE_54650	2.15e-98	303.0	COG0366@1|root,COG0366@2|Bacteria,1G0NX@1117|Cyanobacteria	1117|Cyanobacteria	G	PFAM alpha amylase, catalytic	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,CBM_20
k59_1684470_1	396588.Tgr7_1012	2e-105	318.0	COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,1RNAF@1236|Gammaproteobacteria,1WVZB@135613|Chromatiales	135613|Chromatiales	S	Circularly permuted ATP-grasp type 2	-	-	-	-	-	-	-	-	-	-	-	-	CP_ATPgrasp_2
k59_16968_1	572547.Amico_1041	2.31e-51	172.0	COG0177@1|root,COG0177@2|Bacteria,3TB1B@508458|Synergistetes	508458|Synergistetes	L	Base excision DNA repair protein	-	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
k59_906899_1	378806.STAUR_3085	1.07e-23	108.0	COG1404@1|root,COG4412@1|root,COG1404@2|Bacteria,COG4412@2|Bacteria,1REF1@1224|Proteobacteria,42Q4N@68525|delta/epsilon subdivisions,2WS51@28221|Deltaproteobacteria,2YWNR@29|Myxococcales	28221|Deltaproteobacteria	O	Fibronectin type 3 domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M6,Peptidase_S8
k59_462176_1	1502724.FF80_00623	1.28e-62	206.0	COG1252@1|root,COG1252@2|Bacteria,1MX96@1224|Proteobacteria,2TQT2@28211|Alphaproteobacteria,3N6XJ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	ndh	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,cNMP_binding
k59_795260_1	670307.HYPDE_38393	7.48e-61	203.0	COG0446@1|root,COG2146@1|root,COG0446@2|Bacteria,COG2146@2|Bacteria,1NR3M@1224|Proteobacteria,2TS0K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.18.1.1	ko:K05297	ko00071,map00071	-	R02000	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim,Reductase_C,Rieske
k59_961874_1	1278073.MYSTI_04422	1.51e-21	89.7	COG0792@1|root,COG0792@2|Bacteria,1N6VN@1224|Proteobacteria,42VES@68525|delta/epsilon subdivisions,2WRSC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Belongs to the UPF0102 family	-	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
k59_1184174_2	269799.Gmet_0448	5e-30	118.0	COG1449@1|root,COG1449@2|Bacteria,1R51R@1224|Proteobacteria,42P4W@68525|delta/epsilon subdivisions,2WK2R@28221|Deltaproteobacteria,43U1D@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Glycosyl hydrolase family 57	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_57
k59_795266_1	1177179.A11A3_02362	0.000169	44.3	COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,1RPHI@1236|Gammaproteobacteria,1XIK3@135619|Oceanospirillales	135619|Oceanospirillales	J	histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
k59_795266_2	640081.Dsui_3140	1.85e-38	137.0	COG2976@1|root,COG2976@2|Bacteria,1N117@1224|Proteobacteria,2VSHE@28216|Betaproteobacteria,2KWT1@206389|Rhodocyclales	206389|Rhodocyclales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TPR_21
k59_1129365_1	1287116.X734_28750	2.86e-19	94.4	COG2303@1|root,COG2303@2|Bacteria,1MU3F@1224|Proteobacteria,2TT3C@28211|Alphaproteobacteria,43IR6@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	GMC oxidoreductase	-	-	1.1.5.9,1.1.99.21	ko:K08261,ko:K19813	ko00030,ko00051,ko01100,ko01110,ko01130,map00030,map00051,map01100,map01110,map01130	-	R00305,R02925	RC00066,RC00102	ko00000,ko00001,ko01000	-	-	-	FAD_binding_2,FAD_binding_3,GMC_oxred_C,GMC_oxred_N,NAD_binding_8
k59_1628284_1	861299.J421_2768	3.12e-88	290.0	COG0086@1|root,COG0086@2|Bacteria,1ZSZQ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_517265_1	1366050.N234_32165	2.06e-79	261.0	COG0204@1|root,COG0236@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0236@2|Bacteria,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2WGHZ@28216|Betaproteobacteria,1KG5N@119060|Burkholderiaceae	28216|Betaproteobacteria	IQ	amp-dependent synthetase and ligase	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,Acyltransferase,PP-binding
k59_72210_1	2325.TKV_c07370	1.04e-46	163.0	COG0161@1|root,COG0161@2|Bacteria,1TP9N@1239|Firmicutes,25E7B@186801|Clostridia,42FK5@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor	bioA	-	2.6.1.62	ko:K00833	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03231	RC00006,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_406019_1	595460.RRSWK_02095	8.24e-34	129.0	COG4146@1|root,COG4146@2|Bacteria,2J29I@203682|Planctomycetes	203682|Planctomycetes	S	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
k59_1684519_1	1278073.MYSTI_04046	2.15e-11	69.3	COG0265@1|root,COG0823@1|root,COG2234@1|root,COG0265@2|Bacteria,COG0823@2|Bacteria,COG2234@2|Bacteria,1MV86@1224|Proteobacteria,42Z17@68525|delta/epsilon subdivisions,2WURE@28221|Deltaproteobacteria,2YUPJ@29|Myxococcales	28221|Deltaproteobacteria	O	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	PA,PD40,PDZ_2,Peptidase_M28
k59_127135_1	83406.HDN1F_19300	4.89e-62	199.0	COG3332@1|root,COG3332@2|Bacteria,1RDBS@1224|Proteobacteria,1S43Y@1236|Gammaproteobacteria,1J6C9@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Transport and Golgi organisation 2	-	-	-	-	-	-	-	-	-	-	-	-	TANGO2
k59_1241333_1	1120972.AUMH01000009_gene493	1.03e-79	246.0	COG1830@1|root,COG1830@2|Bacteria,1TR60@1239|Firmicutes,4HT90@91061|Bacilli	91061|Bacilli	G	DeoC/LacD family aldolase	-	-	4.1.2.13	ko:K11645	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
k59_517272_1	1231391.AMZF01000110_gene850	1.58e-40	147.0	COG1304@1|root,COG1304@2|Bacteria,1MUEZ@1224|Proteobacteria,2W0CR@28216|Betaproteobacteria,3T6NS@506|Alcaligenaceae	28216|Betaproteobacteria	C	FMN-dependent dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_dh
k59_627691_1	1121904.ARBP01000013_gene402	3.51e-99	309.0	COG1472@1|root,COG1472@2|Bacteria,4NE90@976|Bacteroidetes	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 3 family	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
k59_1018008_1	396588.Tgr7_0480	4.73e-33	125.0	COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,1RMZ5@1236|Gammaproteobacteria,1WVUX@135613|Chromatiales	135613|Chromatiales	M	Lipid A biosynthesis	lpxL	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
k59_462224_1	1043493.BBLU01000005_gene2015	1.24e-07	53.5	COG0624@1|root,COG0624@2|Bacteria,2GM84@201174|Actinobacteria	201174|Actinobacteria	E	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
k59_462224_2	1416759.AYMR01000013_gene2493	7.28e-74	239.0	COG2704@1|root,COG2704@2|Bacteria,2GKYB@201174|Actinobacteria,4FM9K@85023|Microbacteriaceae	201174|Actinobacteria	S	Anaerobic c4-dicarboxylate membrane transporter	dcuB	-	-	ko:K07792	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.13.1	-	-	DcuA_DcuB
k59_1628301_1	1437824.BN940_09056	7.63e-95	283.0	COG0396@1|root,COG0396@2|Bacteria,1MUGK@1224|Proteobacteria,2VNGT@28216|Betaproteobacteria,3T1QJ@506|Alcaligenaceae	28216|Betaproteobacteria	O	ATPases associated with a variety of cellular activities	sufC	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
k59_127148_1	640512.BC1003_6005	2.05e-101	310.0	COG3119@1|root,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,2VNBG@28216|Betaproteobacteria,1K297@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Pfam Sulfatase	-	-	3.1.6.6	ko:K01133	-	-	-	-	ko00000,ko01000	-	-	-	DUF4976,Sulfatase
k59_961926_1	1128421.JAGA01000002_gene1054	8.25e-15	72.8	COG1611@1|root,COG1611@2|Bacteria,2NPJB@2323|unclassified Bacteria	2|Bacteria	S	Belongs to the LOG family	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	DNA_processg_A,Lysine_decarbox
k59_572174_1	1229780.BN381_80228	0.00031	42.7	COG1960@1|root,COG1960@2|Bacteria,2GIX8@201174|Actinobacteria,3UX43@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_572174_2	1449350.OCH239_17405	8.93e-14	73.6	COG0583@1|root,COG0583@2|Bacteria,1PX1B@1224|Proteobacteria,2TUE7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Transcriptional regulator, LysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_127149_2	1329516.JPST01000012_gene119	1.47e-26	107.0	COG0362@1|root,COG0362@2|Bacteria,1TP4I@1239|Firmicutes,4H9NC@91061|Bacilli,27BMN@186824|Thermoactinomycetaceae	91061|Bacilli	G	6-phosphogluconate dehydrogenase, C-terminal domain	gnd	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
k59_1018027_1	768670.Calni_0366	2.08e-12	69.3	COG0772@1|root,COG0772@2|Bacteria,2GF50@200930|Deferribacteres	200930|Deferribacteres	M	Peptidoglycan polymerase that is essential for cell wall elongation	rodA	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
k59_1018027_2	936573.HMPREF1147_1373	1.7e-12	68.6	COG0768@1|root,COG0768@2|Bacteria,1TQHY@1239|Firmicutes,4H3C8@909932|Negativicutes	909932|Negativicutes	M	Penicillin-binding protein 2	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
k59_127159_1	767029.HMPREF9154_0470	5.43e-21	94.0	COG0524@1|root,COG0524@2|Bacteria,2I04R@201174|Actinobacteria,4DRJY@85009|Propionibacteriales	201174|Actinobacteria	H	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway	rbsK	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
k59_1684555_1	43354.JOIJ01000015_gene1235	3.22e-28	117.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,2GMMM@201174|Actinobacteria,4DZV3@85010|Pseudonocardiales	201174|Actinobacteria	EU	Dipeptidyl aminopeptidase acylaminoacyl peptidase	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
k59_739883_1	1121479.AUBS01000041_gene664	9.64e-15	76.6	COG0711@1|root,COG0711@2|Bacteria,1R6C0@1224|Proteobacteria,2U8BK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	-	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B,OSCP
k59_349798_1	1123366.TH3_20122	7.07e-92	287.0	COG2766@1|root,COG2766@2|Bacteria,1MVW7@1224|Proteobacteria,2TTW4@28211|Alphaproteobacteria,2JQY3@204441|Rhodospirillales	204441|Rhodospirillales	T	PrkA AAA domain	-	-	-	ko:K07180	-	-	-	-	ko00000	-	-	-	AAA_PrkA,PrkA
k59_349798_2	1002340.AFCF01000022_gene1454	2.93e-36	135.0	COG2718@1|root,COG2718@2|Bacteria,1MWQM@1224|Proteobacteria,2TTWI@28211|Alphaproteobacteria,34F3E@302485|Phaeobacter	28211|Alphaproteobacteria	S	Protein of unknown function (DUF444)	yhbH	-	-	ko:K09786	-	-	-	-	ko00000	-	-	-	DUF444
k59_1241377_1	237368.SCABRO_04027	4.54e-52	172.0	COG0644@1|root,COG0644@2|Bacteria	2|Bacteria	C	geranylgeranyl reductase activity	prnA	-	1.14.19.9	ko:K14266	ko00404,ko01130,map00404,map01130	M00789,M00790	R09570	RC00949	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_halogenase
k59_17069_2	861299.J421_2106	3.76e-41	137.0	COG1146@1|root,COG1146@2|Bacteria,1ZU19@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
k59_239367_2	1122605.KB893649_gene3763	5.64e-35	125.0	COG0262@1|root,COG0262@2|Bacteria	2|Bacteria	H	dihydrofolate reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
k59_961980_1	648996.Theam_0171	5.69e-60	201.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,2G3NT@200783|Aquificae	200783|Aquificae	F	Catalyzes the synthesis of GMP from XMP	guaA	GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
k59_72295_1	644966.Tmar_1896	3.24e-50	177.0	COG3547@1|root,COG3547@2|Bacteria,1VI3C@1239|Firmicutes,25AXZ@186801|Clostridia	186801|Clostridia	L	PFAM transposase IS116 IS110 IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_517344_1	243159.AFE_2069	2.57e-140	409.0	COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,1RP4D@1236|Gammaproteobacteria,2NCFD@225057|Acidithiobacillales	225057|Acidithiobacillales	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_517344_2	1121927.GOHSU_35_00440	8.01e-12	65.1	COG0135@1|root,COG0135@2|Bacteria,2IHPP@201174|Actinobacteria,4GDTC@85026|Gordoniaceae	201174|Actinobacteria	E	N-(5'phosphoribosyl)anthranilate (PRA) isomerase	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
k59_961990_1	177437.HRM2_21820	1.18e-07	54.7	COG0517@1|root,COG0618@1|root,COG0517@2|Bacteria,COG0618@2|Bacteria,1QW11@1224|Proteobacteria,42Q56@68525|delta/epsilon subdivisions,2WJXU@28221|Deltaproteobacteria,2MI8T@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS,DHH,DHHA1
k59_961990_2	1206743.BAGM01000199_gene983	6.52e-17	81.3	COG0038@1|root,COG0517@1|root,COG0038@2|Bacteria,COG0517@2|Bacteria,2GPPN@201174|Actinobacteria,4FZU3@85025|Nocardiaceae	201174|Actinobacteria	P	Voltage gated chloride channel	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,Voltage_CLC
k59_1462510_1	880073.Calab_2438	5.28e-110	335.0	COG0443@1|root,COG0443@2|Bacteria,2NNU1@2323|unclassified Bacteria	2|Bacteria	O	Heat shock 70 kDa protein	dnaK	GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0018995,GO:0019219,GO:0019222,GO:0020003,GO:0022607,GO:0030430,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0033643,GO:0033646,GO:0033655,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043230,GO:0043531,GO:0043656,GO:0043657,GO:0043933,GO:0044085,GO:0044183,GO:0044215,GO:0044216,GO:0044217,GO:0044421,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0065010,GO:0070887,GO:0071310,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
k59_1406786_2	926569.ANT_02850	6.79e-51	174.0	COG1236@1|root,COG1236@2|Bacteria,2G62G@200795|Chloroflexi	200795|Chloroflexi	J	Beta-Casp domain	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_6,RMMBL
k59_627782_1	379066.GAU_2584	1.66e-31	124.0	COG0006@1|root,COG0006@2|Bacteria,1ZSPF@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Metallopeptidase family M24	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M24
k59_1740121_1	671143.DAMO_1877	1.78e-62	210.0	COG5000@1|root,COG5000@2|Bacteria,2NQZA@2323|unclassified Bacteria	2|Bacteria	T	Multi-sensor signal transduction histidine kinase	ntrB	-	2.7.13.3	ko:K07710	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_8
k59_1517740_1	518766.Rmar_1750	6.53e-23	101.0	COG1629@1|root,COG4774@1|root,COG1629@2|Bacteria,COG4774@2|Bacteria,4P230@976|Bacteroidetes	2|Bacteria	P	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	CarbopepD_reg_2,CarboxypepD_reg,Plug,STN,TonB_dep_Rec
k59_1184323_1	1192034.CAP_8115	1.64e-55	188.0	COG2114@1|root,COG2114@2|Bacteria,1MV1V@1224|Proteobacteria,42N5S@68525|delta/epsilon subdivisions,2X5DN@28221|Deltaproteobacteria,2YUJ5@29|Myxococcales	28221|Deltaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc
k59_627792_1	485918.Cpin_4061	8.87e-12	71.2	COG1752@1|root,COG1752@2|Bacteria,4NIDR@976|Bacteroidetes,1IUTY@117747|Sphingobacteriia	976|Bacteroidetes	S	Esterase of the alpha-beta hydrolase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
k59_907061_2	311424.DhcVS_89	2.82e-34	120.0	COG2963@1|root,COG2963@2|Bacteria,2GAW0@200795|Chloroflexi,34DGC@301297|Dehalococcoidia	301297|Dehalococcoidia	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
k59_406142_1	373994.Riv7116_2277	5.37e-74	225.0	COG0139@1|root,COG0139@2|Bacteria,1G55P@1117|Cyanobacteria,1HQFQ@1161|Nostocales	1117|Cyanobacteria	E	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP	-	-	3.5.4.19	ko:K01496	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04037	RC01055	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-CH
k59_73894_2	1400525.JNIU01000001_gene483	2.04e-18	84.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria,4BPVK@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	G	C4-dicarboxylate anaerobic carrier	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_1131010_1	272134.KB731324_gene5169	1.95e-13	69.3	COG0438@1|root,COG0438@2|Bacteria,1G271@1117|Cyanobacteria,1H9H0@1150|Oscillatoriales	1117|Cyanobacteria	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
k59_1131010_2	1224136.AMFN01000003_gene2777	3.63e-50	174.0	COG0438@1|root,COG0438@2|Bacteria,1MVKK@1224|Proteobacteria,1RQ8J@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Glycosyl Transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_2,Glyco_transf_4,Glycos_transf_1
k59_1185882_1	384765.SIAM614_25197	1.88e-62	201.0	COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,2TSRD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
k59_741470_1	160799.PBOR_19970	1.89e-18	87.0	COG2220@1|root,COG2220@2|Bacteria,1TQR1@1239|Firmicutes,4HR40@91061|Bacilli,26X4K@186822|Paenibacillaceae	91061|Bacilli	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
k59_1296975_1	926569.ANT_05380	1e-79	246.0	COG1239@1|root,COG1239@2|Bacteria,2G5WJ@200795|Chloroflexi	200795|Chloroflexi	H	introduces a magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX	-	-	6.6.1.1	ko:K03404,ko:K03405	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	-	AAA_5,Mg_chelatase,VWA_2
k59_73921_1	402881.Plav_2877	1.25e-97	305.0	COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,2TQRQ@28211|Alphaproteobacteria,1JNET@119043|Rhodobiaceae	28211|Alphaproteobacteria	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parC	-	-	ko:K02621	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_1185893_1	479434.Sthe_1399	3.24e-78	256.0	COG1529@1|root,COG1529@2|Bacteria,2G608@200795|Chloroflexi,27XWN@189775|Thermomicrobia	189775|Thermomicrobia	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_573811_1	234267.Acid_5578	7.89e-21	94.4	COG0577@1|root,COG0577@2|Bacteria	234267.Acid_5578|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_573811_2	1267535.KB906767_gene5109	5.72e-07	49.3	COG1695@1|root,COG1695@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	-	-	-	-	-	-	-	-	-	PadR
k59_128897_1	379066.GAU_2204	8.4e-58	207.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
k59_1575027_1	525909.Afer_2015	1.91e-09	54.7	COG2963@1|root,COG2963@2|Bacteria,2IMG6@201174|Actinobacteria	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
k59_1575027_2	886293.Sinac_0715	2.27e-25	105.0	COG2801@1|root,COG2801@2|Bacteria,2IZI7@203682|Planctomycetes	203682|Planctomycetes	L	COG2801 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve_3
k59_1629929_1	986075.CathTA2_2353	3.54e-57	190.0	COG0372@1|root,COG0372@2|Bacteria,1TPPS@1239|Firmicutes,4H9YE@91061|Bacilli	91061|Bacilli	C	Belongs to the citrate synthase family	citZ	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
k59_128902_1	632245.CLP_1024	7.27e-38	141.0	COG0595@1|root,COG0595@2|Bacteria,1TQ9G@1239|Firmicutes,2488J@186801|Clostridia,36DE5@31979|Clostridiaceae	186801|Clostridia	S	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,RMMBL
k59_518974_1	566466.NOR53_579	1.81e-71	228.0	COG0624@1|root,COG0624@2|Bacteria,1MVUX@1224|Proteobacteria,1RPPD@1236|Gammaproteobacteria,1J8J6@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Peptidase family M28	-	-	3.5.1.6,3.5.1.87	ko:K06016	ko00240,ko01100,map00240,map01100	M00046	R00905,R04666	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
k59_1741669_1	671143.DAMO_2019	7.64e-81	248.0	COG2801@1|root,COG2801@2|Bacteria	2|Bacteria	L	transposition	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve,rve_3
k59_1629934_1	1122947.FR7_4108	2.21e-47	166.0	COG3876@1|root,COG3876@2|Bacteria,1VRMG@1239|Firmicutes,4H3RF@909932|Negativicutes	909932|Negativicutes	S	Protein of unknown function (DUF1343)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1343
k59_128904_1	1123501.KB902286_gene2048	5.44e-79	249.0	COG4225@1|root,COG4225@2|Bacteria,1NIRN@1224|Proteobacteria,2UE10@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	BNR repeat-containing family member	-	-	-	-	-	-	-	-	-	-	-	-	BNR_4
k59_28893_1	1449355.JQNR01000005_gene5901	6.95e-20	94.4	COG1721@1|root,COG1721@2|Bacteria,2I9E2@201174|Actinobacteria	201174|Actinobacteria	S	protein some members contain a von Willebrand factor type A vWA domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
k59_84432_1	46234.ANA_C13142	2.18e-79	253.0	COG3385@1|root,COG3385@2|Bacteria,1G2T1@1117|Cyanobacteria,1HMX0@1161|Nostocales	1117|Cyanobacteria	L	PFAM Transposase DDE domain	-	-	-	ko:K07495	-	-	-	-	ko00000	-	-	-	DDE_5,DDE_Tnp_1
k59_861418_1	768671.ThimaDRAFT_3148	3.65e-100	328.0	COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,1RSNV@1236|Gammaproteobacteria,1WXPZ@135613|Chromatiales	135613|Chromatiales	L	DEAD DEAH box	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,HTH_42,Helicase_C
k59_529245_1	926569.ANT_04500	6.1e-23	96.7	COG0674@1|root,COG0674@2|Bacteria,2G5UG@200795|Chloroflexi	200795|Chloroflexi	C	Pyruvate:ferredoxin oxidoreductase core domain II	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
k59_529245_2	926569.ANT_04510	5.4e-93	278.0	COG1013@1|root,COG1013@2|Bacteria,2G5VG@200795|Chloroflexi	200795|Chloroflexi	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
k59_920248_2	365044.Pnap_4500	1.22e-25	101.0	COG0546@1|root,COG0546@2|Bacteria,1QEY0@1224|Proteobacteria,2VJ8N@28216|Betaproteobacteria,4ACDT@80864|Comamonadaceae	28216|Betaproteobacteria	S	phosphoglycolate phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	HAD
k59_250817_2	290400.Jann_2942	6.68e-44	150.0	COG3090@1|root,COG3090@2|Bacteria,1QYHJ@1224|Proteobacteria,2UI8I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
k59_1085412_1	1121861.KB899926_gene2583	9.17e-29	110.0	COG0625@1|root,COG0625@2|Bacteria,1RK1K@1224|Proteobacteria	1224|Proteobacteria	O	Glutathione S-transferase, N-terminal domain	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_3,GST_N,GST_N_3
k59_1474831_1	926569.ANT_03780	2.45e-80	247.0	COG2199@1|root,COG3706@2|Bacteria,2G85T@200795|Chloroflexi	2|Bacteria	T	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF,HATPase_c,HisKA,PAS,Response_reg
k59_1474831_2	926569.ANT_03770	1.43e-42	145.0	COG1719@1|root,COG1719@2|Bacteria,2G8D0@200795|Chloroflexi	200795|Chloroflexi	S	4-vinyl reductase, 4VR	-	-	-	-	-	-	-	-	-	-	-	-	V4R
k59_1363373_1	1313172.YM304_36290	1.45e-70	226.0	COG0863@1|root,COG0863@2|Bacteria,2I9DJ@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the N(4) N(6)-methyltransferase family	-	-	2.1.1.113,2.1.1.72	ko:K00571,ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
k59_475233_1	926569.ANT_19820	1.43e-24	105.0	COG0457@1|root,COG0457@2|Bacteria,2G8PU@200795|Chloroflexi	200795|Chloroflexi	S	Peptidase_C39 like family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C39_2
k59_1085451_1	1122605.KB893631_gene3911	1.53e-81	255.0	COG0719@1|root,COG0719@2|Bacteria,4NFXH@976|Bacteroidetes,1IP4R@117747|Sphingobacteriia	976|Bacteroidetes	O	FeS assembly protein SufB	sufB	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
k59_1308225_1	1333998.M2A_2143	9.54e-38	131.0	COG0041@1|root,COG0041@2|Bacteria,1RCWJ@1224|Proteobacteria,2U58D@28211|Alphaproteobacteria,4BQ8N@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
k59_1751477_1	715451.ambt_20910	4.89e-71	243.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,464D1@72275|Alteromonadaceae	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_751529_2	857087.Metme_3746	4.01e-11	67.8	COG4773@1|root,COG4773@2|Bacteria,1QVK7@1224|Proteobacteria,1T53A@1236|Gammaproteobacteria,1XDUB@135618|Methylococcales	135618|Methylococcales	P	TonB-dependent Receptor Plug	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
k59_751534_1	335992.SAR11_0620	1.05e-86	265.0	COG0379@1|root,COG0379@2|Bacteria,1MWQU@1224|Proteobacteria,2TRPG@28211|Alphaproteobacteria,4BPDK@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
k59_1085480_1	1370120.AUWR01000055_gene3128	2.42e-33	128.0	COG0111@1|root,COG0111@2|Bacteria,2GP09@201174|Actinobacteria,236EU@1762|Mycobacteriaceae	201174|Actinobacteria	EH	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_139445_2	265072.Mfla_1365	1.83e-31	120.0	COG1280@1|root,COG1280@2|Bacteria,1RET0@1224|Proteobacteria,2VSM6@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Lysine exporter protein LysE YggA	-	-	-	-	-	-	-	-	-	-	-	-	LysE
k59_139445_3	864051.BurJ1DRAFT_2515	1.75e-10	65.1	COG0697@1|root,COG0697@2|Bacteria,1MZQM@1224|Proteobacteria,2VI5H@28216|Betaproteobacteria,1KJF2@119065|unclassified Burkholderiales	28216|Betaproteobacteria	EG	EamA-like transporter family	yijE_1	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_861495_1	572547.Amico_1041	7.74e-37	134.0	COG0177@1|root,COG0177@2|Bacteria,3TB1B@508458|Synergistetes	508458|Synergistetes	L	Base excision DNA repair protein	-	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
k59_1253744_1	697284.ERIC2_c02870	9.34e-24	91.7	COG1278@1|root,COG1278@2|Bacteria,1VEE0@1239|Firmicutes,4HNJC@91061|Bacilli,26YYK@186822|Paenibacillaceae	91061|Bacilli	K	Cold-shock protein	cspA	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
k59_1253744_2	690850.Desaf_1653	2.35e-28	106.0	COG1047@1|root,COG1047@2|Bacteria,1RD35@1224|Proteobacteria,42MCS@68525|delta/epsilon subdivisions,2WQGI@28221|Deltaproteobacteria,2MBXZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	Peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	FKBP_C
k59_807287_1	1304874.JAFY01000002_gene648	5.39e-74	231.0	COG3643@1|root,COG3643@2|Bacteria,3TA3X@508458|Synergistetes	508458|Synergistetes	E	Formiminotransferase domain, N-terminal subdomain	-	-	-	-	-	-	-	-	-	-	-	-	FTCD,FTCD_N
k59_1418565_1	1192759.AKIB01000043_gene424	9.26e-73	241.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,2TRKI@28211|Alphaproteobacteria,2K00X@204457|Sphingomonadales	204457|Sphingomonadales	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_1085501_1	987059.RBXJA2T_07583	2.11e-08	60.5	COG0577@1|root,COG0577@2|Bacteria,1MWBK@1224|Proteobacteria,2VNEP@28216|Betaproteobacteria,1KPE6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_696899_1	1453501.JELR01000001_gene2121	4.65e-115	351.0	COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,1RMXI@1236|Gammaproteobacteria,464BP@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	Peptidase family M3	dcp	-	3.4.15.5	ko:K01284	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
k59_418159_1	1082933.MEA186_09545	1.05e-81	254.0	COG2072@1|root,COG2072@2|Bacteria,1MWPJ@1224|Proteobacteria,2TSQA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Flavoprotein involved in K transport	-	-	-	ko:K07222	-	-	-	-	ko00000	-	-	-	Pyr_redox_3
k59_1474916_1	479434.Sthe_1119	1.31e-35	130.0	COG0346@1|root,COG0346@2|Bacteria,2G7QI@200795|Chloroflexi,27XQU@189775|Thermomicrobia	189775|Thermomicrobia	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	1.13.11.2	ko:K00446	ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220	M00569	R00816,R04089,R05295,R05404,R05406,R07795	RC00387,RC00643,RC01075,RC01364,RC01914	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase
k59_1474916_2	1121924.ATWH01000005_gene2643	1.6e-15	74.7	COG0684@1|root,COG0684@2|Bacteria,2I8VQ@201174|Actinobacteria,4FPCD@85023|Microbacteriaceae	201174|Actinobacteria	H	Aldolase/RraA	-	-	4.1.3.17	ko:K10218	ko00362,ko00660,ko01120,map00362,map00660,map01120	-	R00008,R00350	RC00067,RC00502,RC01205	ko00000,ko00001,ko01000	-	-	-	RraA-like
k59_362049_1	1042163.BRLA_c023910	6e-18	88.2	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1UYA0@1239|Firmicutes,4HA4F@91061|Bacilli,274Q0@186822|Paenibacillaceae	91061|Bacilli	GT	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
k59_1308269_2	1123392.AQWL01000005_gene3098	6.78e-58	191.0	COG0617@1|root,COG0617@2|Bacteria,1MU2X@1224|Proteobacteria,2VIN5@28216|Betaproteobacteria,1KRHG@119069|Hydrogenophilales	119069|Hydrogenophilales	J	Probable RNA and SrmB- binding site of polymerase A	-	-	2.7.7.72	ko:K00974	ko03013,map03013	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	Archease,HD,PolyA_pol,PolyA_pol_RNAbd
k59_84544_1	517417.Cpar_0052	2.98e-08	60.8	COG0477@1|root,COG2814@2|Bacteria,1FDXJ@1090|Chlorobi	1090|Chlorobi	EGP	major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
k59_1529810_1	765913.ThidrDRAFT_2654	1.11e-41	147.0	COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,1RN36@1236|Gammaproteobacteria,1WW3F@135613|Chromatiales	135613|Chromatiales	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
k59_1308277_1	1004149.AFOE01000042_gene2712	3.85e-42	154.0	COG0508@1|root,COG0508@2|Bacteria,4NFB9@976|Bacteroidetes,1HZ6M@117743|Flavobacteriia	976|Bacteroidetes	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhC	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_974866_1	1191523.MROS_0727	7.84e-65	224.0	COG0436@1|root,COG0436@2|Bacteria	2|Bacteria	E	Aminotransferase	-	-	-	ko:K21572	-	-	-	-	ko00000,ko02000	8.A.46.1,8.A.46.3	-	-	SusD-like_3,SusD_RagB
k59_195539_1	326427.Cagg_0040	1.06e-136	400.0	COG2224@1|root,COG2224@2|Bacteria,2G61J@200795|Chloroflexi,374VM@32061|Chloroflexia	32061|Chloroflexia	C	PFAM isocitrate lyase and phosphorylmutase	-	-	4.1.3.1	ko:K01637	ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200	M00012	R00479	RC00311,RC00313	ko00000,ko00001,ko00002,ko01000	-	-	-	ICL
k59_807316_2	1392490.JHZX01000001_gene2251	0.000436	42.0	COG3462@1|root,COG3462@2|Bacteria,4NVJQ@976|Bacteroidetes,1I42E@117743|Flavobacteriia	976|Bacteroidetes	S	Short C-terminal domain	-	-	-	ko:K08982	-	-	-	-	ko00000	-	-	-	SHOCT
k59_1418599_1	1121423.JONT01000013_gene309	1.33e-45	161.0	COG0162@1|root,COG0162@2|Bacteria,1TPGN@1239|Firmicutes,247QC@186801|Clostridia,2601M@186807|Peptococcaceae	186801|Clostridia	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
k59_1697618_1	349163.Acry_2441	5.38e-41	144.0	COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,2TRBW@28211|Alphaproteobacteria,2JPS7@204441|Rhodospirillales	204441|Rhodospirillales	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_1697618_2	882378.RBRH_01964	1.08e-08	55.8	COG1028@1|root,COG1028@2|Bacteria,1MUUV@1224|Proteobacteria,2VK0U@28216|Betaproteobacteria,1K19I@119060|Burkholderiaceae	28216|Betaproteobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_529395_1	604331.AUHY01000006_gene831	1.12e-125	374.0	COG0365@1|root,COG0365@2|Bacteria,1WNGH@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	AMP-binding enzyme C-terminal domain	-	-	6.2.1.32	ko:K08295	ko00627,ko01120,map00627,map01120	-	R00982	RC00004,RC00174	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C
k59_1474962_1	103733.JNYO01000001_gene205	1.38e-12	66.2	COG2197@1|root,COG2197@2|Bacteria,2IGCB@201174|Actinobacteria,4EEFJ@85010|Pseudonocardiales	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_1141645_1	1521187.JPIM01000103_gene1045	4.13e-07	57.0	COG4767@1|root,COG4767@2|Bacteria	2|Bacteria	V	VanZ like family	-	-	-	-	-	-	-	-	-	-	-	-	VanZ
k59_639533_1	661087.HMPREF1008_00594	1.63e-53	187.0	COG1190@1|root,COG1190@2|Bacteria,2GKE0@201174|Actinobacteria,4CUAX@84998|Coriobacteriia	84998|Coriobacteriia	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon,tRNA_bind
k59_418219_2	287.DR97_1971	5.89e-40	140.0	COG0796@1|root,COG0796@2|Bacteria,1NAI2@1224|Proteobacteria,1RPU9@1236|Gammaproteobacteria,1YDVI@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	-	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	-	Asp_Glu_race
k59_920411_1	1380391.JIAS01000011_gene5265	7.17e-84	268.0	COG1657@1|root,COG1657@2|Bacteria,1MUIP@1224|Proteobacteria,2TRF3@28211|Alphaproteobacteria,2JQUI@204441|Rhodospirillales	204441|Rhodospirillales	I	Squalene-hopene cyclase C-terminal domain	-	-	4.2.1.129,5.4.99.17	ko:K06045	ko00909,ko01110,map00909,map01110	-	R07322,R07323	RC01850,RC01851	ko00000,ko00001,ko01000	-	-	-	SQHop_cyclase_C,SQHop_cyclase_N
k59_1308326_1	324602.Caur_2901	4.2e-59	199.0	COG1894@1|root,COG1894@2|Bacteria,2G5W1@200795|Chloroflexi,374WU@32061|Chloroflexia	32061|Chloroflexia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	-	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
k59_751612_1	1240349.ANGC01000015_gene719	1.16e-52	174.0	COG2884@1|root,COG2884@2|Bacteria,2GJE1@201174|Actinobacteria,4FU0M@85025|Nocardiaceae	201174|Actinobacteria	D	cell division	ftsE	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030145,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
k59_1751582_1	349124.Hhal_0830	1.29e-99	298.0	COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,1RMAX@1236|Gammaproteobacteria,1WX8X@135613|Chromatiales	135613|Chromatiales	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	-	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
k59_1198562_1	926569.ANT_27120	7.24e-46	166.0	COG0574@1|root,COG0574@2|Bacteria	2|Bacteria	G	Belongs to the PEP-utilizing enzyme family	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PPDK_N
k59_1198562_2	926569.ANT_27130	2.7e-15	75.5	COG0592@1|root,COG0592@2|Bacteria,2G641@200795|Chloroflexi	200795|Chloroflexi	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
k59_1420803_1	69328.PVLB_16445	1.34e-25	111.0	COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,1RPAG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	COG1020 Non-ribosomal peptide synthetase modules and related proteins	pvdJ	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,TauD,Thioesterase
k59_1700120_1	1501230.ET33_23125	1.14e-21	97.1	COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,4HCH3@91061|Bacilli,26Y8E@186822|Paenibacillaceae	91061|Bacilli	I	Enoyl-CoA hydratase/isomerase	crt	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
k59_1531759_1	379066.GAU_2102	6.34e-31	125.0	COG1629@1|root,COG4219@1|root,COG1629@2|Bacteria,COG4219@2|Bacteria,1ZUHU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KPT	BlaR1 peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M56,Plug
k59_809548_1	1123274.KB899427_gene3354	3.75e-45	162.0	COG1155@1|root,COG1155@2|Bacteria,2J5EF@203691|Spirochaetes	203691|Spirochaetes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	-	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
k59_86505_1	1191523.MROS_2604	4.97e-19	91.7	COG5448@1|root,COG5448@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2460
k59_1753370_1	1449353.JQMQ01000005_gene4283	1.88e-62	206.0	COG0501@1|root,COG0501@2|Bacteria,2GKJQ@201174|Actinobacteria,2NF02@228398|Streptacidiphilus	201174|Actinobacteria	O	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
k59_141538_1	1379270.AUXF01000007_gene936	2.41e-45	166.0	COG1629@1|root,COG4771@2|Bacteria,1ZUKQ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	P	Outer membrane protein beta-barrel family	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
k59_1587897_1	502025.Hoch_0458	2.9e-65	223.0	COG0823@1|root,COG1228@1|root,COG0823@2|Bacteria,COG1228@2|Bacteria,1MX3A@1224|Proteobacteria,438QJ@68525|delta/epsilon subdivisions,2X3XW@28221|Deltaproteobacteria,2YXIE@29|Myxococcales	28221|Deltaproteobacteria	QU	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,PD40
k59_1310799_1	413816.BBJP01000023_gene1490	1.09e-41	149.0	COG1063@1|root,arCOG01621@2157|Archaea,2XTZT@28890|Euryarchaeota,23SIP@183963|Halobacteria	183963|Halobacteria	E	COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases	-	-	-	-	-	-	-	-	-	-	-	-	ADH_zinc_N
k59_1477131_2	290399.Arth_2933	1.42e-10	64.3	COG4962@1|root,COG4962@2|Bacteria,2GKKJ@201174|Actinobacteria,1WANZ@1268|Micrococcaceae	201174|Actinobacteria	U	Secretion system protein	flpF	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
k59_1587901_1	742823.HMPREF9465_01533	2.52e-21	98.6	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2VH4I@28216|Betaproteobacteria,4PQU7@995019|Sutterellaceae	28216|Betaproteobacteria	L	UvrD-like helicase C-terminal domain	uvrD	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_420270_1	562970.Btus_0326	5.54e-44	157.0	COG1055@1|root,COG1055@2|Bacteria,1TPNN@1239|Firmicutes,4HAIC@91061|Bacilli	91061|Bacilli	P	Membrane	-	-	-	ko:K03893	-	-	-	-	ko00000,ko02000	2.A.45.1,3.A.4.1	-	-	CitMHS
k59_1310815_2	390989.JOEG01000009_gene1127	2.79e-33	123.0	COG0667@1|root,COG0667@2|Bacteria,2GMNA@201174|Actinobacteria,4D93W@85008|Micromonosporales	201174|Actinobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_1477146_1	1463825.JNXC01000045_gene3036	1.11e-36	137.0	COG2040@1|root,COG2040@2|Bacteria,2HSC2@201174|Actinobacteria,4ED7T@85010|Pseudonocardiales	201174|Actinobacteria	E	Homocysteine S-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	S-methyl_trans
k59_1256007_1	525904.Tter_1913	5.42e-62	202.0	COG2234@1|root,COG2234@2|Bacteria,2NP7A@2323|unclassified Bacteria	2|Bacteria	S	Peptidase M28	ywaD	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
k59_1587922_1	861299.J421_2560	6.09e-46	160.0	COG0533@1|root,COG0533@2|Bacteria,1ZT0P@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
k59_1602058_1	1238182.C882_2003	3.01e-84	262.0	COG4091@1|root,COG4091@2|Bacteria,1MUZX@1224|Proteobacteria,2TRZ0@28211|Alphaproteobacteria,2JPX8@204441|Rhodospirillales	204441|Rhodospirillales	E	homoserine dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,NAD_binding_3,SAF
k59_654411_1	1094557.ME3_00899	2.82e-06	48.1	COG1862@1|root,COG1862@2|Bacteria,1MZT2@1224|Proteobacteria,2UBZ6@28211|Alphaproteobacteria,48TZU@772|Bartonellaceae	28211|Alphaproteobacteria	U	Preprotein translocase subunit	yajC	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
k59_654411_2	1047013.AQSP01000034_gene1654	2.23e-49	169.0	COG0343@1|root,COG0343@2|Bacteria,2NNQS@2323|unclassified Bacteria	2|Bacteria	J	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046116,GO:0046483,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
k59_433899_1	278963.ATWD01000003_gene138	5.58e-73	233.0	COG3039@1|root,COG3039@2|Bacteria,3Y8N9@57723|Acidobacteria,2JNID@204432|Acidobacteriia	204432|Acidobacteriia	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_878496_2	1187848.AJYQ01000121_gene3243	1.32e-15	79.3	COG0648@1|root,COG0648@2|Bacteria,1MX4Y@1224|Proteobacteria,1RQ60@1236|Gammaproteobacteria,1XSWK@135623|Vibrionales	135623|Vibrionales	L	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin	nfo	GO:0003674,GO:0003824,GO:0003906,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0008833,GO:0009987,GO:0016787,GO:0016788,GO:0016888,GO:0016893,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
k59_1380203_1	398525.KB900701_gene5932	3.3e-52	188.0	COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,3JTQ7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DZR,Guanylate_cyc,SAM_1
k59_1491650_2	290397.Adeh_2391	1.65e-05	47.0	COG0784@1|root,COG0784@2|Bacteria,1QYG7@1224|Proteobacteria,43E8C@68525|delta/epsilon subdivisions,2X7NA@28221|Deltaproteobacteria,2Z11B@29|Myxococcales	28221|Deltaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
k59_265760_1	1382306.JNIM01000001_gene1179	4.15e-95	296.0	COG0465@1|root,COG0465@2|Bacteria,2G5J3@200795|Chloroflexi	200795|Chloroflexi	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,Peptidase_M41
k59_1212322_2	1297863.APJF01000026_gene3668	5.11e-46	150.0	COG3461@1|root,COG3461@2|Bacteria,1MZZN@1224|Proteobacteria,2UED8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	ko:K09700	-	-	-	-	ko00000	-	-	-	Rubrerythrin
k59_766869_1	300852.55772555	8.41e-25	107.0	COG0168@1|root,COG0168@2|Bacteria,1WIWU@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	COG0168 Trk-type K transport systems, membrane components	-	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
k59_878516_1	331869.BAL199_09900	2.01e-76	235.0	COG1011@1|root,COG1011@2|Bacteria,1NYX7@1224|Proteobacteria,2TVNX@28211|Alphaproteobacteria,4BRS6@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase	-	-	3.8.1.2	ko:K01560	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	HAD_2
k59_433919_2	313596.RB2501_04000	5.16e-77	235.0	COG0426@1|root,COG0426@2|Bacteria	2|Bacteria	C	nitric oxide reductase activity	-	-	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	Fer4,Lactamase_B
k59_265776_1	715451.ambt_09125	7.6e-27	102.0	COG0296@1|root,COG0296@2|Bacteria,1N8WX@1224|Proteobacteria,1S8R5@1236|Gammaproteobacteria,467S6@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	Belongs to the glycosyl hydrolase 13 family	-	-	-	-	-	-	-	-	-	-	-	-	AMPK1_CBM,CBM_48
k59_599865_2	1197951.I6R109_9CAUD	7.37e-18	84.0	4QAYZ@10239|Viruses,4QVHQ@35237|dsDNA viruses  no RNA stage,4QTY8@28883|Caudovirales	28883|Caudovirales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_654453_1	243233.MCA2186	1.4e-38	140.0	COG1028@1|root,COG1028@2|Bacteria,1MUCH@1224|Proteobacteria,1RNAA@1236|Gammaproteobacteria,1XDTD@135618|Methylococcales	135618|Methylococcales	IQ	short-chain dehydrogenase reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_1544566_1	670487.Ocepr_2155	6.97e-11	63.2	COG2329@1|root,COG2329@2|Bacteria	2|Bacteria	S	heme oxygenase (decyclizing) activity	-	-	-	-	-	-	-	-	-	-	-	-	ABM
k59_1491697_1	1254432.SCE1572_04135	9.64e-50	167.0	COG2513@1|root,COG2513@2|Bacteria,1N4VT@1224|Proteobacteria,42NZ1@68525|delta/epsilon subdivisions,2WNX5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate	prpB	-	4.1.3.30	ko:K03417	ko00640,map00640	-	R00409	RC00286,RC00287	ko00000,ko00001,ko01000	-	-	-	PEP_mutase
k59_823299_1	861299.J421_6043	5.41e-24	96.3	2AUAW@1|root,31JYI@2|Bacteria,1ZV7R@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_823299_2	998674.ATTE01000001_gene3668	1.36e-16	72.4	2EGPU@1|root,33AFZ@2|Bacteria,1NH69@1224|Proteobacteria,1SHN2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_654469_1	627192.SLG_01700	6.41e-07	50.1	COG0036@1|root,COG0036@2|Bacteria,1MUZM@1224|Proteobacteria,2TQKR@28211|Alphaproteobacteria,2K1ZB@204457|Sphingomonadales	204457|Sphingomonadales	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
k59_654469_2	1205680.CAKO01000038_gene1950	5.79e-11	68.2	COG5360@1|root,COG5360@2|Bacteria,1MUJ4@1224|Proteobacteria,2TR5G@28211|Alphaproteobacteria,2JQ9J@204441|Rhodospirillales	204441|Rhodospirillales	S	Heparinase II/III-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Hepar_II_III,Hepar_II_III_N
k59_1325560_1	118173.KB235914_gene509	1.1e-15	83.6	COG0419@1|root,COG0419@2|Bacteria,1GD2P@1117|Cyanobacteria	1117|Cyanobacteria	L	PFAM RecF RecN SMC N terminal domain	-	-	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	SbcCD_C
k59_492229_1	991905.SL003B_2455	1.64e-54	190.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TRM1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	COG1593 TRAP-type C4-dicarboxylate transport system, large permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctM,DctQ
k59_324580_1	379066.GAU_1892	6.84e-64	218.0	COG1193@1|root,COG1193@2|Bacteria,1ZSWM@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_V,Smr
k59_1491708_1	1713.JOFV01000007_gene2895	1.48e-68	219.0	COG0714@1|root,COG0714@2|Bacteria,2GK07@201174|Actinobacteria,4F0EB@85016|Cellulomonadaceae	201174|Actinobacteria	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
k59_1047895_1	266117.Rxyl_2372	6.84e-72	223.0	COG0259@1|root,COG0259@2|Bacteria,2GJCR@201174|Actinobacteria,4CQ9H@84995|Rubrobacteria	84995|Rubrobacteria	H	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)	pdxH	-	1.4.3.5	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	M00124	R00277,R00278,R01710,R01711	RC00048,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_phzG_C,Putative_PNPOx
k59_100687_1	1300345.LF41_2593	3.98e-10	65.5	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1T234@1236|Gammaproteobacteria,1X903@135614|Xanthomonadales	135614|Xanthomonadales	S	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
k59_209664_1	1236959.BAMT01000006_gene274	5.69e-19	92.0	COG0457@1|root,COG0457@2|Bacteria,1MUZK@1224|Proteobacteria,2VHVG@28216|Betaproteobacteria,2KNGN@206350|Nitrosomonadales	206350|Nitrosomonadales	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9,TPR_1
k59_1158446_1	1379698.RBG1_1C00001G1752	8.9e-44	161.0	COG0728@1|root,COG0728@2|Bacteria,2NNX8@2323|unclassified Bacteria	2|Bacteria	U	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
k59_1270935_1	189753.AXAS01000075_gene6010	9e-143	419.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2TRXG@28211|Alphaproteobacteria,3JVHX@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Transposase	-	-	-	ko:K07487	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_1655696_2	1121422.AUMW01000033_gene3368	3.41e-15	74.7	COG0745@1|root,COG0745@2|Bacteria,1TPWS@1239|Firmicutes,25AZ2@186801|Clostridia,2605V@186807|Peptococcaceae	186801|Clostridia	K	PFAM response regulator receiver	phoP	-	-	ko:K02483,ko:K07658	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_937746_2	1219084.AP014508_gene1326	1.04e-23	100.0	COG2045@1|root,COG2045@2|Bacteria,2GD5S@200918|Thermotogae	200918|Thermotogae	H	Belongs to the ComB family	comB	GO:0003674,GO:0003824,GO:0016829,GO:0016830,GO:0016831,GO:0050545	3.1.3.71	ko:K05979	ko00680,ko01120,map00680,map01120	M00358	R05789	RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	2-ph_phosp
k59_324617_1	1095769.CAHF01000022_gene140	3e-48	164.0	COG0589@1|root,COG0589@2|Bacteria,1QD8E@1224|Proteobacteria,2VT0Q@28216|Betaproteobacteria,47495@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_654511_1	1380387.JADM01000007_gene806	2.04e-13	72.8	COG1028@1|root,COG1028@2|Bacteria,1N4J7@1224|Proteobacteria,1RQ0S@1236|Gammaproteobacteria	1236|Gammaproteobacteria	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_1158472_1	876044.IMCC3088_225	5.84e-19	93.2	COG4591@1|root,COG4591@2|Bacteria,1Q2BY@1224|Proteobacteria,1RY89@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
k59_878610_1	234267.Acid_3236	3.26e-84	269.0	COG2010@1|root,COG4993@1|root,COG2010@2|Bacteria,COG4993@2|Bacteria	2|Bacteria	G	Dehydrogenase	-	-	1.1.5.2	ko:K00117	ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130	-	R06620	RC00066	ko00000,ko00001,ko01000	-	-	-	Cytochrome_CBB3,PQQ,PQQ_2
k59_1102046_1	1121943.KB899990_gene3837	9.75e-96	288.0	COG0329@1|root,COG0329@2|Bacteria,1MXM5@1224|Proteobacteria	1224|Proteobacteria	EM	Belongs to the DapA family	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
k59_1102046_2	1123504.JQKD01000007_gene3336	2.54e-07	51.6	COG1304@1|root,COG1304@2|Bacteria,1MUEZ@1224|Proteobacteria,2VHZV@28216|Betaproteobacteria,4ADHI@80864|Comamonadaceae	28216|Betaproteobacteria	C	FMN-dependent dehydrogenase	mdlB	-	1.1.99.31	ko:K15054	ko00627,ko01120,map00627,map01120	-	R04160,R07664	RC00240	ko00000,ko00001,ko01000	-	-	-	FMN_dh
k59_1602171_1	324602.Caur_3141	2.47e-17	86.3	COG2909@1|root,COG2909@2|Bacteria	2|Bacteria	K	trisaccharide binding	-	-	-	ko:K03556	-	-	-	-	ko00000,ko03000	-	-	-	AAA_16,GerE,NACHT,TPR_12
k59_1767153_1	926569.ANT_14310	8.73e-55	180.0	COG0648@1|root,COG0648@2|Bacteria	2|Bacteria	L	deoxyribonuclease IV (phage-T4-induced) activity	-	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
k59_878624_1	231434.JQJH01000035_gene787	1.27e-60	200.0	COG2021@1|root,COG2021@2|Bacteria,1MVJV@1224|Proteobacteria,2TQYA@28211|Alphaproteobacteria,3NA8H@45404|Beijerinckiaceae	28211|Alphaproteobacteria	E	alpha/beta hydrolase fold	metXA	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
k59_766967_1	1123278.KB893427_gene1239	1.25e-54	189.0	COG0531@1|root,COG0531@2|Bacteria,4NHS2@976|Bacteroidetes,47MER@768503|Cytophagia	976|Bacteroidetes	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
k59_1047935_1	7165.AGAP000300-PA	4.96e-25	105.0	COG0458@1|root,KOG0370@2759|Eukaryota,38CAC@33154|Opisthokonta,3B9FF@33208|Metazoa,3CS9A@33213|Bilateria,41U31@6656|Arthropoda,3SJKC@50557|Insecta,44ZM5@7147|Diptera,45EVJ@7148|Nematocera	33208|Metazoa	F	Carbamoyl-phosphate synthase large chain	CAD	GO:0000050,GO:0000052,GO:0000166,GO:0001882,GO:0001884,GO:0002119,GO:0002134,GO:0002164,GO:0003674,GO:0003824,GO:0004070,GO:0004087,GO:0004088,GO:0004151,GO:0004672,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006082,GO:0006139,GO:0006206,GO:0006207,GO:0006213,GO:0006220,GO:0006221,GO:0006228,GO:0006464,GO:0006468,GO:0006520,GO:0006525,GO:0006526,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007275,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009605,GO:0009653,GO:0009719,GO:0009725,GO:0009791,GO:0009887,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0016053,GO:0016301,GO:0016310,GO:0016363,GO:0016597,GO:0016740,GO:0016741,GO:0016743,GO:0016772,GO:0016773,GO:0016787,GO:0016810,GO:0016812,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0017144,GO:0018107,GO:0018130,GO:0018193,GO:0018210,GO:0019103,GO:0019240,GO:0019438,GO:0019538,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0019899,GO:0022612,GO:0030424,GO:0030554,GO:0031406,GO:0031667,GO:0031974,GO:0031981,GO:0032501,GO:0032502,GO:0032549,GO:0032551,GO:0032553,GO:0032555,GO:0032557,GO:0032559,GO:0032868,GO:0032991,GO:0033267,GO:0034399,GO:0034404,GO:0034641,GO:0034654,GO:0035295,GO:0035639,GO:0036094,GO:0036211,GO:0036477,GO:0042221,GO:0042455,GO:0042594,GO:0042802,GO:0042995,GO:0043005,GO:0043025,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043195,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043434,GO:0043436,GO:0043603,GO:0043604,GO:0043679,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0044297,GO:0044306,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044456,GO:0044463,GO:0044464,GO:0045202,GO:0046051,GO:0046112,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046394,GO:0046483,GO:0046777,GO:0046872,GO:0046914,GO:0048513,GO:0048565,GO:0048731,GO:0048732,GO:0048856,GO:0050896,GO:0055086,GO:0055123,GO:0060465,GO:0070013,GO:0070335,GO:0070406,GO:0071704,GO:0071941,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:0097458,GO:0098793,GO:0120025,GO:0120038,GO:0140096,GO:0150034,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901652,GO:1901657,GO:1901659,GO:1901698,GO:1901700,GO:1905905	2.1.3.2,3.5.2.3,6.3.5.5	ko:K11540	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R01397,R01993,R10948,R10949	RC00002,RC00010,RC00043,RC00064,RC00632,RC02750,RC02798,RC02850,RC03314	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	Amidohydro_1,CPSase_L_D2,CPSase_L_D3,CPSase_sm_chain,GATase,MGS,OTCace,OTCace_N
k59_1047935_2	588596.U9U7K2	9.27e-06	48.1	COG0458@1|root,KOG0370@2759|Eukaryota,38CAC@33154|Opisthokonta,3NW85@4751|Fungi	4751|Fungi	F	Carbamoylphosphate	URA2	GO:0000050,GO:0003674,GO:0003824,GO:0003922,GO:0004070,GO:0004087,GO:0004088,GO:0004151,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006082,GO:0006139,GO:0006142,GO:0006206,GO:0006207,GO:0006520,GO:0006525,GO:0006526,GO:0006541,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009892,GO:0009987,GO:0016020,GO:0016021,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0016787,GO:0016810,GO:0016812,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019219,GO:0019222,GO:0019627,GO:0019752,GO:0019856,GO:0031224,GO:0031323,GO:0031324,GO:0034641,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044425,GO:0044444,GO:0044464,GO:0045934,GO:0045984,GO:0046112,GO:0046394,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0055086,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071941,GO:0072527,GO:0072528,GO:0080090,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.3.2,6.3.5.5	ko:K01954,ko:K11541	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R01397,R10948,R10949	RC00002,RC00010,RC00043,RC00064,RC02750,RC02798,RC02850,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,CPSase_sm_chain,GATase,MGS,OTCace,OTCace_N
k59_1434951_1	926569.ANT_14030	4.94e-89	283.0	COG0480@1|root,COG0480@2|Bacteria,2G680@200795|Chloroflexi	200795|Chloroflexi	J	elongation factor Tu domain 2 protein	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_1047940_1	631454.N177_3090	3.89e-90	280.0	COG3333@1|root,COG3333@2|Bacteria	2|Bacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	-	-	-	-	-	-	-	-	-	TctA
k59_1325633_1	1097668.BYI23_C008310	5.71e-11	60.8	COG1366@1|root,COG1366@2|Bacteria,1N7D9@1224|Proteobacteria,2VWJI@28216|Betaproteobacteria,1K963@119060|Burkholderiaceae	28216|Betaproteobacteria	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	ko:K06378	-	-	-	-	ko00000	-	-	-	STAS,STAS_2
k59_1214107_1	1121033.AUCF01000009_gene996	5.59e-65	221.0	COG0247@1|root,COG0277@1|root,COG0479@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,COG0479@2|Bacteria,1MU6Y@1224|Proteobacteria,2TSN5@28211|Alphaproteobacteria,2JRH7@204441|Rhodospirillales	204441|Rhodospirillales	C	4Fe-4S dicluster domain	-	-	-	ko:K18930	-	-	-	-	ko00000	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_7,Fer4_8
k59_656017_1	1033737.CAEV01000029_gene334	5.11e-12	68.2	COG0398@1|root,COG0398@2|Bacteria,1V3DJ@1239|Firmicutes,24G6T@186801|Clostridia,36J4F@31979|Clostridiaceae	186801|Clostridia	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
k59_656017_2	1045004.OKIT_1580	5.32e-06	48.5	COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,4H9PZ@91061|Bacilli,4AX4Y@81850|Leuconostocaceae	91061|Bacilli	P	COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components	oppC	-	-	ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1,OppC_N
k59_1436670_1	1123508.JH636440_gene2185	1.96e-19	87.4	COG0614@1|root,COG0614@2|Bacteria,2IXWX@203682|Planctomycetes	203682|Planctomycetes	P	PFAM periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
k59_1436670_2	360911.EAT1b_1361	9.47e-10	59.7	COG0247@1|root,COG2181@1|root,COG0247@2|Bacteria,COG2181@2|Bacteria,1TPG1@1239|Firmicutes,4HB2J@91061|Bacilli,3WFBW@539002|Bacillales incertae sedis	91061|Bacilli	C	4Fe-4S dicluster domain	ywjF	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
k59_939448_1	518766.Rmar_1649	4.48e-60	203.0	COG1115@1|root,COG1115@2|Bacteria,4NDX7@976|Bacteroidetes,1FIXE@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	E	Sodium:alanine symporter family	-	-	-	ko:K03310	-	-	-	-	ko00000	2.A.25	-	-	Na_Ala_symp
k59_1716116_1	1211115.ALIQ01000149_gene358	0.000473	48.5	COG1638@1|root,COG1638@2|Bacteria,1MUBS@1224|Proteobacteria,2TUKV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component	dctP5	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_326413_1	313598.MED152_07260	1.09e-44	163.0	COG1680@1|root,COG1680@2|Bacteria,4NEVS@976|Bacteroidetes,1HY9H@117743|Flavobacteriia,3VWMZ@52959|Polaribacter	976|Bacteroidetes	V	Beta-lactamase class C and other penicillin binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_1327424_1	103690.17134448	1.31e-08	61.2	COG0642@1|root,COG0745@1|root,COG4252@1|root,COG0642@2|Bacteria,COG0745@2|Bacteria,COG4252@2|Bacteria,1G3JA@1117|Cyanobacteria,1HJCM@1161|Nostocales	1117|Cyanobacteria	T	Integral membrane sensor hybrid histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE2,HATPase_c,HisKA,Response_reg
k59_1493579_1	926566.Terro_0575	2.31e-12	72.0	COG0497@1|root,COG0497@2|Bacteria,3Y6KC@57723|Acidobacteria,2JME0@204432|Acidobacteriia	204432|Acidobacteriia	L	DNA recombination	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_380570_1	1049564.TevJSym_ad00960	2.26e-57	192.0	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,1RMN6@1236|Gammaproteobacteria,1J4T7@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA	-	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
k59_211227_2	1140.Synpcc7942_0099	2.23e-34	121.0	COG1694@1|root,COG1694@2|Bacteria,1G25W@1117|Cyanobacteria,1H41T@1129|Synechococcus	1117|Cyanobacteria	S	MazG nucleotide pyrophosphohydrolase domain	-	-	-	-	-	-	-	-	-	-	-	-	MazG
k59_211227_3	1242864.D187_006668	6.34e-17	87.4	COG2885@1|root,COG2885@2|Bacteria,1R4WG@1224|Proteobacteria,42TD5@68525|delta/epsilon subdivisions,2WP3U@28221|Deltaproteobacteria,2YZG5@29|Myxococcales	28221|Deltaproteobacteria	M	OmpA family	-	-	-	ko:K03286	-	-	-	-	ko00000,ko02000	1.B.6	-	-	DUF5011,HYR,OMP_b-brl,OmpA,TSP_3
k59_1327436_2	488538.SAR116_0338	1.52e-40	140.0	COG4032@1|root,COG4032@2|Bacteria,1RFK9@1224|Proteobacteria,2U75B@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_547041_1	999411.HMPREF1092_00849	3.01e-18	82.4	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,247PV@186801|Clostridia,36EGR@31979|Clostridiaceae	186801|Clostridia	IQ	reductase	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_547041_2	517417.Cpar_0128	3.38e-17	75.9	COG0236@1|root,COG0236@2|Bacteria,1FE83@1090|Chlorobi	1090|Chlorobi	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
k59_939470_1	497964.CfE428DRAFT_3450	5.77e-05	47.4	COG2096@1|root,COG2096@2|Bacteria,46T1G@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Cobalamin adenosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Cob_adeno_trans
k59_939470_2	926569.ANT_11270	4.35e-28	107.0	COG1811@1|root,COG1811@2|Bacteria,2G6S2@200795|Chloroflexi	200795|Chloroflexi	S	Protein of unknown function (DUF554)	-	-	-	ko:K07150	-	-	-	-	ko00000	-	-	-	DUF554
k59_1272890_1	43989.cce_1403	4.59e-77	249.0	COG0591@1|root,COG0591@2|Bacteria,1G1JV@1117|Cyanobacteria,3KI6G@43988|Cyanothece	1117|Cyanobacteria	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	putP	-	-	-	-	-	-	-	-	-	-	-	SSF
k59_601434_1	83406.HDN1F_31680	2.29e-91	277.0	COG1536@1|root,COG1536@2|Bacteria,1MV9X@1224|Proteobacteria,1RM9B@1236|Gammaproteobacteria,1J56V@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	N	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation	fliG	GO:0005575,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464	-	ko:K02410	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliG_C,FliG_M,FliG_N
k59_380603_1	1089552.KI911559_gene439	6.44e-37	140.0	COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,2TRBQ@28211|Alphaproteobacteria,2JPTT@204441|Rhodospirillales	204441|Rhodospirillales	C	COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes	sucA	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
k59_1327476_1	502025.Hoch_6894	2.7e-42	152.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,42MM1@68525|delta/epsilon subdivisions,2WIU7@28221|Deltaproteobacteria,2YUQI@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	bioF	-	2.3.1.29,2.3.1.47	ko:K00639,ko:K00652	ko00260,ko00780,ko01100,map00260,map00780,map01100	M00123,M00573,M00577	R00371,R03210,R10124	RC00004,RC00039,RC00394,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_1282190_2	1035191.HMPREF0185_00801	2.34e-50	165.0	COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,2U758@28211|Alphaproteobacteria,2KGKV@204458|Caulobacterales	204458|Caulobacterales	M	Belongs to the ompA family	-	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	OmpA
k59_1337763_1	257313.BP1049	1.04e-90	276.0	COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,2VIRX@28216|Betaproteobacteria,3T20J@506|Alcaligenaceae	28216|Betaproteobacteria	F	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
k59_392666_1	323097.Nham_1183	1.52e-09	60.5	COG2010@1|root,COG2010@2|Bacteria,1MV6D@1224|Proteobacteria,2TVYT@28211|Alphaproteobacteria,3JT2A@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
k59_170269_1	309801.trd_A0454	4.83e-05	45.8	COG0843@1|root,COG0843@2|Bacteria	2|Bacteria	C	heme-copper terminal oxidase activity	coxA2	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_170269_2	309801.trd_A0453	3.66e-44	149.0	COG1622@1|root,COG1622@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,Cupredoxin_1
k59_1282194_1	1278073.MYSTI_01180	1.18e-56	190.0	COG1988@1|root,COG1988@2|Bacteria,1RA9E@1224|Proteobacteria,438D4@68525|delta/epsilon subdivisions,2X3NA@28221|Deltaproteobacteria,2YWMP@29|Myxococcales	28221|Deltaproteobacteria	S	LexA-binding, inner membrane-associated putative hydrolase	-	-	-	ko:K07038	-	-	-	-	ko00000	-	-	-	YdjM
k59_225876_1	246197.MXAN_4473	3.03e-128	375.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,42M98@68525|delta/epsilon subdivisions,2WMKB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM Integrase catalytic	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,HTH_Tnp_1,rve
k59_225876_2	640511.BC1002_6823	2.43e-39	133.0	COG2963@1|root,COG2963@2|Bacteria,1N8Y3@1224|Proteobacteria,2VY0M@28216|Betaproteobacteria,1KAA0@119060|Burkholderiaceae	28216|Betaproteobacteria	L	PFAM transposase IS3 IS911 family protein	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_1115563_1	1239962.C943_00789	7.69e-94	293.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,4NHS5@976|Bacteroidetes,47MWY@768503|Cytophagia	976|Bacteroidetes	EU	Peptidase S9 prolyl oligopeptidase active site domain protein	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,PD40,Peptidase_S9
k59_726357_1	107636.JQNK01000009_gene1841	4.01e-103	306.0	COG0451@1|root,COG0451@2|Bacteria,1MXKV@1224|Proteobacteria,2TRM0@28211|Alphaproteobacteria,36X8E@31993|Methylocystaceae	28211|Alphaproteobacteria	GM	3-beta hydroxysteroid dehydrogenase/isomerase family	-	-	4.1.1.35	ko:K08678	ko00520,ko01100,map00520,map01100	M00361	R01384	RC00508	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
k59_225883_1	671143.DAMO_0982	3.92e-41	148.0	COG0535@1|root,COG0535@2|Bacteria,2NQVH@2323|unclassified Bacteria	2|Bacteria	S	Elongator protein 3, MiaB family, Radical SAM	pqqE	-	-	ko:K22226,ko:K22227	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
k59_448374_1	517418.Ctha_0508	4.87e-34	128.0	COG2045@1|root,COG2045@2|Bacteria	2|Bacteria	H	2-phosphosulfolactate phosphatase activity	comB	GO:0003674,GO:0003824,GO:0016829,GO:0016830,GO:0016831,GO:0050545	3.1.3.71	ko:K05979	ko00680,ko01120,map00680,map01120	M00358	R05789	RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	2-ph_phosp
k59_614983_1	1297863.APJF01000006_gene1247	2.5e-08	60.5	COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,3JTQ7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Adenylate and Guanylate cyclase catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_16,Abhydrolase_1,DZR,Guanylate_cyc,TPR_4
k59_1449111_1	671143.DAMO_2962	4.24e-121	359.0	COG0056@1|root,COG0056@2|Bacteria,2NP0S@2323|unclassified Bacteria	2|Bacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016469,GO:0030312,GO:0032991,GO:0040007,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045259,GO:0045260,GO:0071944,GO:0098796,GO:0098797	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	iSB619.SA_RS10975	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
k59_1504428_1	1123354.AUDR01000013_gene712	8.92e-121	361.0	COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,2VGZ9@28216|Betaproteobacteria,1KS96@119069|Hydrogenophilales	119069|Hydrogenophilales	J	Aminoacyl-tRNA editing domain	-	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
k59_670728_1	1203568.HMPREF1484_01541	4.34e-13	74.3	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,2GJGR@201174|Actinobacteria,4FCA7@85020|Dermabacteraceae	201174|Actinobacteria	S	Competence protein	comEC	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
k59_559285_1	1122603.ATVI01000012_gene1146	1.93e-89	271.0	COG2070@1|root,COG2070@2|Bacteria,1MU0U@1224|Proteobacteria,1RTQR@1236|Gammaproteobacteria,1X9H0@135614|Xanthomonadales	135614|Xanthomonadales	S	Nitronate monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	NMO
k59_1449125_1	926554.KI912650_gene4185	4.94e-18	88.6	COG2133@1|root,COG2133@2|Bacteria,1WK3B@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	pyrroloquinoline quinone binding	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1560121_1	1448389.BAVQ01000013_gene3979	2.26e-28	118.0	COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria	201174|Actinobacteria	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	GO:0000731,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0018130,GO:0019438,GO:0019985,GO:0030312,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042276,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:1901360,GO:1901362,GO:1901576	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_1282221_1	1242864.D187_000513	4.19e-18	83.2	COG4221@1|root,COG4221@2|Bacteria,1QTXD@1224|Proteobacteria	1224|Proteobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	MA20_36825	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_614999_1	536019.Mesop_0936	2.77e-32	124.0	COG3118@1|root,COG3118@2|Bacteria,1MV0R@1224|Proteobacteria,2TS5X@28211|Alphaproteobacteria,43H9J@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	O	Thioredoxin	trxA2	-	-	ko:K03671,ko:K05838	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	TPR_19,TPR_20,Thioredoxin
k59_614999_2	395963.Bind_2793	7.76e-15	72.0	COG2802@1|root,COG2802@2|Bacteria,1NV9N@1224|Proteobacteria,2TQZ4@28211|Alphaproteobacteria,3NA1T@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	ATP-dependent protease La (LON) substrate-binding domain	lonD	-	3.4.21.53	ko:K01338,ko:K07157	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	LON_substr_bdg
k59_225913_1	236097.ADG881_2837	6.06e-51	173.0	COG1354@1|root,COG1354@2|Bacteria,1MVCN@1224|Proteobacteria,1RNBB@1236|Gammaproteobacteria,1XHG7@135619|Oceanospirillales	135619|Oceanospirillales	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
k59_615004_1	1208923.CKBE_00345	2.78e-87	270.0	COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,2VHSH@28216|Betaproteobacteria,1KPQC@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	H	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
k59_615004_2	768671.ThimaDRAFT_3667	1.63e-06	48.5	COG0066@1|root,COG0066@2|Bacteria,1MVXB@1224|Proteobacteria,1RNMK@1236|Gammaproteobacteria,1WW8F@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
k59_837347_1	880072.Desac_2831	2.08e-71	225.0	COG0223@1|root,COG0223@2|Bacteria,1MWH1@1224|Proteobacteria,42QSB@68525|delta/epsilon subdivisions,2WMWD@28221|Deltaproteobacteria,2MQSR@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Formyl transferase, C-terminal domain	arnG	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
k59_1560131_2	1123371.ATXH01000010_gene753	3.6e-59	195.0	COG1559@1|root,COG1559@2|Bacteria,2GHNN@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
k59_559300_1	1121335.Clst_2347	8.4e-94	287.0	COG1156@1|root,COG1156@2|Bacteria,1VSU1@1239|Firmicutes,2496H@186801|Clostridia,3WG8C@541000|Ruminococcaceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit	ntpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_948701_1	1089552.KI911559_gene410	4.65e-54	192.0	COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,2TS89@28211|Alphaproteobacteria,2JPCA@204441|Rhodospirillales	204441|Rhodospirillales	E	NAD-specific glutamate dehydrogenase	gdhA	-	1.4.1.2	ko:K15371	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	-	R00243	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	Bac_GDH
k59_225917_1	247634.GPB2148_190	2.26e-84	253.0	COG0346@1|root,COG0346@2|Bacteria,1MWCV@1224|Proteobacteria,1S1HV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
k59_670748_1	1382356.JQMP01000003_gene1683	7.61e-61	211.0	COG1529@1|root,COG1529@2|Bacteria,2G82V@200795|Chloroflexi,27XQT@189775|Thermomicrobia	189775|Thermomicrobia	C	Dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_114717_1	933262.AXAM01000005_gene2470	1.02e-85	267.0	COG0183@1|root,COG0183@2|Bacteria,1MU8C@1224|Proteobacteria,42N6X@68525|delta/epsilon subdivisions,2WJIE@28221|Deltaproteobacteria,2MK14@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Thiolase, C-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_1560152_1	553171.HMPREF0648_0838	2.5e-40	152.0	COG0532@1|root,COG0532@2|Bacteria,4NGP3@976|Bacteroidetes,2FM01@200643|Bacteroidia	976|Bacteroidetes	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N
k59_448439_1	866771.HMPREF9296_2217	1.97e-25	114.0	COG1629@1|root,COG4771@2|Bacteria,4NEIG@976|Bacteroidetes,2FM1K@200643|Bacteroidia	976|Bacteroidetes	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,CarboxypepD_reg,OMP_b-brl_3,Plug
k59_1171016_1	370438.PTH_2736	1.52e-14	74.3	COG0322@1|root,COG0322@2|Bacteria,1TP4B@1239|Firmicutes,247TQ@186801|Clostridia,260I5@186807|Peptococcaceae	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
k59_170350_1	1123269.NX02_19715	4.85e-80	251.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2TSA7@28211|Alphaproteobacteria,2K3IJ@204457|Sphingomonadales	204457|Sphingomonadales	L	Transposase domain (DUF772)	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
k59_837384_1	1121949.AQXT01000002_gene1026	1.34e-216	609.0	COG4372@1|root,COG4372@2|Bacteria,1MUCX@1224|Proteobacteria,2TR59@28211|Alphaproteobacteria,43Z37@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	COG3436 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
k59_781923_1	1380394.JADL01000009_gene3414	1.46e-62	202.0	COG0451@1|root,COG0451@2|Bacteria,1MWYB@1224|Proteobacteria,2TSDE@28211|Alphaproteobacteria,2JWE9@204441|Rhodospirillales	204441|Rhodospirillales	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
k59_170369_1	525904.Tter_0396	1.35e-75	235.0	COG2141@1|root,COG2141@2|Bacteria,2NQM2@2323|unclassified Bacteria	2|Bacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_170369_2	1268635.Loa_01459	4.01e-24	97.4	COG2094@1|root,COG2094@2|Bacteria,1RE0A@1224|Proteobacteria,1S9CM@1236|Gammaproteobacteria,1JD7P@118969|Legionellales	118969|Legionellales	L	Belongs to the DNA glycosylase MPG family	-	-	3.2.2.21	ko:K03652	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Pur_DNA_glyco
k59_392780_1	862908.BMS_0300	3.22e-09	60.5	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,42MFK@68525|delta/epsilon subdivisions,2MSMZ@213481|Bdellovibrionales,2WKBU@28221|Deltaproteobacteria	213481|Bdellovibrionales	E	extracellular solute-binding protein, family 5	-	-	-	ko:K02035,ko:K13893	ko02010,ko02024,map02010,map02024	M00239,M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.21,3.A.1.5.24	-	-	SBP_bac_5
k59_225979_1	215803.DB30_4648	3.95e-17	85.9	COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,42PGI@68525|delta/epsilon subdivisions,2WMBT@28221|Deltaproteobacteria,2YYDR@29|Myxococcales	28221|Deltaproteobacteria	S	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
k59_281663_1	926569.ANT_19480	9.91e-75	246.0	COG1138@1|root,COG1138@2|Bacteria,2G5SZ@200795|Chloroflexi	200795|Chloroflexi	O	PFAM Cytochrome C assembly protein	ccmF	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
k59_59236_1	485913.Krac_0317	7.62e-133	391.0	COG3547@1|root,COG3547@2|Bacteria	2|Bacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1393331_3	1120953.AUBH01000002_gene1457	1.01e-06	49.3	COG4660@1|root,COG4660@2|Bacteria,1MW6N@1224|Proteobacteria,1RMEH@1236|Gammaproteobacteria,464BB@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	Part of a membrane complex involved in electron transport	rnfE	-	-	ko:K03613	-	-	-	-	ko00000	-	-	-	Rnf-Nqr
k59_1671477_1	1121106.JQKB01000092_gene4142	3.71e-12	71.6	COG3385@1|root,COG3385@2|Bacteria,1PHKQ@1224|Proteobacteria,2VGVZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
k59_504059_1	1333998.M2A_2352	7.06e-30	116.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,4BP5J@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Aldehyde dehydrogenase family	gabD	GO:0000166,GO:0001505,GO:0003674,GO:0003824,GO:0004777,GO:0005488,GO:0005507,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006105,GO:0006520,GO:0006536,GO:0006538,GO:0006540,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009013,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009266,GO:0009314,GO:0009408,GO:0009416,GO:0009448,GO:0009450,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009628,GO:0009987,GO:0016054,GO:0016491,GO:0016620,GO:0016903,GO:0017144,GO:0019752,GO:0031974,GO:0032787,GO:0036094,GO:0042133,GO:0042135,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0050896,GO:0051287,GO:0055114,GO:0065007,GO:0065008,GO:0070013,GO:0071704,GO:0072329,GO:0072593,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_504059_2	762376.AXYL_02394	1.26e-52	178.0	COG1249@1|root,COG1249@2|Bacteria,1MU2Z@1224|Proteobacteria,2VHFA@28216|Betaproteobacteria,3T1C6@506|Alcaligenaceae	28216|Betaproteobacteria	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family	gor	GO:0003674,GO:0003824,GO:0004362,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006091,GO:0006139,GO:0006725,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009055,GO:0009636,GO:0009987,GO:0015036,GO:0015037,GO:0015038,GO:0015949,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0022900,GO:0031974,GO:0033554,GO:0034599,GO:0034641,GO:0042221,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0055114,GO:0070013,GO:0070887,GO:0071704,GO:0097237,GO:0098754,GO:0098869,GO:1901360,GO:1990748	1.8.1.7	ko:K00383	ko00480,ko04918,map00480,map04918	-	R00094,R00115	RC00011	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_615107_1	1286106.MPL1_02188	8.85e-41	154.0	COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,1RN3Z@1236|Gammaproteobacteria,46034@72273|Thiotrichales	72273|Thiotrichales	U	TIGRFAM type IV pilus secretin (or competence protein) PilQ	pilQ	-	-	ko:K02666	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	AMIN,STN,Secretin,Secretin_N
k59_1504557_1	880073.Calab_2811	1.44e-84	274.0	COG0038@1|root,COG0517@1|root,COG0038@2|Bacteria,COG0517@2|Bacteria,2NPC4@2323|unclassified Bacteria	2|Bacteria	P	Voltage gated chloride channel	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	iAF987.Gmet_3470	CBS,TrkA_C,Voltage_CLC
k59_1282340_1	935261.JAGL01000021_gene504	2.63e-87	267.0	COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,2TT0T@28211|Alphaproteobacteria,43I87@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	ABC-type branched-chain amino acid transport	livK	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_670872_1	2340.JV46_16140	8.66e-15	72.8	COG0244@1|root,COG0244@2|Bacteria,1RAN5@1224|Proteobacteria,1S286@1236|Gammaproteobacteria,1J5V2@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0017148,GO:0019222,GO:0019538,GO:0022625,GO:0022626,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
k59_670872_2	1415780.JPOG01000001_gene2173	2.02e-10	59.3	COG0222@1|root,COG0222@2|Bacteria,1RGU4@1224|Proteobacteria,1S5V7@1236|Gammaproteobacteria,1X721@135614|Xanthomonadales	135614|Xanthomonadales	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	-	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
k59_1393367_1	1123053.AUDG01000003_gene2760	2.98e-37	143.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,1RMAP@1236|Gammaproteobacteria,1WXD9@135613|Chromatiales	135613|Chromatiales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
k59_1504572_1	570967.JMLV01000009_gene1015	4.88e-65	209.0	COG0111@1|root,COG0111@2|Bacteria,1MW1U@1224|Proteobacteria,2TSUU@28211|Alphaproteobacteria,2JPHD@204441|Rhodospirillales	204441|Rhodospirillales	EH	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain	-	-	1.1.1.79,1.1.1.81	ko:K12972	ko00260,ko00620,ko00630,ko01100,ko01110,ko01120,map00260,map00620,map00630,map01100,map01110,map01120	-	R00465,R01388,R01392,R02527	RC00031,RC00042,RC00670	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh_C
k59_1004450_2	1196323.ALKF01000190_gene5455	2.52e-15	76.3	COG2264@1|root,COG2264@2|Bacteria,1TPKI@1239|Firmicutes,4HAMF@91061|Bacilli,26RIX@186822|Paenibacillaceae	91061|Bacilli	J	Methylates ribosomal protein L11	prmA	-	-	ko:K02687	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PrmA
k59_392853_2	378806.STAUR_7764	1.61e-10	63.9	COG1680@1|root,COG1680@2|Bacteria,1QUYZ@1224|Proteobacteria,42PUC@68525|delta/epsilon subdivisions,2WK0V@28221|Deltaproteobacteria,2YXDC@29|Myxococcales	28221|Deltaproteobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_559430_1	177439.DP0617	8.25e-38	138.0	COG1448@1|root,COG1448@2|Bacteria,1MUT0@1224|Proteobacteria	1224|Proteobacteria	E	aminotransferase	aspC	GO:0003674,GO:0003824,GO:0004069,GO:0004838,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006558,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009094,GO:0009095,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0019438,GO:0019752,GO:0019842,GO:0030170,GO:0033585,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0070279,GO:0070547,GO:0071704,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902221,GO:1902223	2.6.1.1,2.6.1.57	ko:K00813,ko:K00832	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	M00024,M00025,M00034,M00040	R00355,R00694,R00734,R00896,R01731,R02433,R02619,R05052,R07396,R10845	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iPC815.YPO1410,iSFxv_1172.SFxv_1000	Aminotran_1_2
k59_559430_2	477184.KYC_25568	1.39e-14	73.2	COG0625@1|root,COG0625@2|Bacteria,1RA4M@1224|Proteobacteria,2VQHN@28216|Betaproteobacteria,3T6KK@506|Alcaligenaceae	28216|Betaproteobacteria	O	Glutathione S-transferase	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_N,GST_N_3
k59_392861_1	378806.STAUR_7722	2.95e-122	370.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,42Y93@68525|delta/epsilon subdivisions,2WU1Y@28221|Deltaproteobacteria,2YWK2@29|Myxococcales	28221|Deltaproteobacteria	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_1227119_1	1120950.KB892772_gene1123	5.3e-29	120.0	COG0515@1|root,COG0515@2|Bacteria,2GJ1J@201174|Actinobacteria,4DNY6@85009|Propionibacteriales	201174|Actinobacteria	KLT	serine threonine protein kinase	pknB	GO:0000270,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008047,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0010698,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0022603,GO:0022604,GO:0030145,GO:0030203,GO:0030234,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032091,GO:0034645,GO:0036211,GO:0040007,GO:0042304,GO:0042546,GO:0042802,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043388,GO:0043393,GO:0043412,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046872,GO:0046890,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051055,GO:0051098,GO:0051099,GO:0051100,GO:0051101,GO:0051128,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0075136,GO:0080090,GO:0098772,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
k59_1393385_1	247634.GPB2148_14	8.26e-81	251.0	COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,1PBHA@1224|Proteobacteria	1224|Proteobacteria	L	Transposase and inactivated derivatives	-	-	2.7.7.49	ko:K00986,ko:K07497	-	-	-	-	ko00000,ko01000	-	-	-	HTH_32,rve,rve_3
k59_1615808_1	224911.27353697	3.1e-63	209.0	COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,1R7DJ@1224|Proteobacteria,2VF2S@28211|Alphaproteobacteria,3K6EG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IM	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	-	-	-	-	-	-	-	-	-	-	-	-	CTP_transf_like,PfkB
k59_226076_1	1232410.KI421424_gene1673	7.61e-56	196.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,42MGP@68525|delta/epsilon subdivisions,2WIZ2@28221|Deltaproteobacteria,43RZ4@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	Bacterial DNA polymerase III alpha subunit	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_1615814_1	930945.SiRe_1855	2.87e-17	85.1	COG0002@1|root,arCOG00495@2157|Archaea,2XQ3U@28889|Crenarchaeota	28889|Crenarchaeota	E	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily	lysY	-	-	ko:K05829	ko00220,ko00300,ko01100,ko01110,ko01210,ko01230,map00220,map00300,map01100,map01110,map01210,map01230	M00031,M00763	R09777,R10931	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
k59_114865_1	671143.DAMO_0706	2.4e-56	190.0	COG0403@1|root,COG0403@2|Bacteria,2NNP1@2323|unclassified Bacteria	2|Bacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	GO:0001505,GO:0003674,GO:0003824,GO:0004375,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006807,GO:0008150,GO:0008152,GO:0009069,GO:0009987,GO:0016491,GO:0016638,GO:0016642,GO:0017144,GO:0019752,GO:0032991,GO:0042133,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901605,GO:1902494,GO:1990204	1.4.4.2	ko:K00281,ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
k59_3852_1	1380355.JNIJ01000022_gene3589	2.8e-99	295.0	COG3246@1|root,COG3246@2|Bacteria,1MZTP@1224|Proteobacteria,2TRG7@28211|Alphaproteobacteria,3JS2V@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	beta-keto acid cleavage enzyme	-	-	2.3.1.247	ko:K18013	ko00310,map00310	-	R10564	RC02728,RC03199	ko00000,ko00001,ko01000	-	-	-	BKACE
k59_392882_2	926550.CLDAP_31100	1.57e-40	143.0	COG0601@1|root,COG0601@2|Bacteria,2G89D@200795|Chloroflexi	200795|Chloroflexi	U	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_1393409_1	1150626.PHAMO_210226	7.44e-83	257.0	COG0639@1|root,COG0639@2|Bacteria,1NPR1@1224|Proteobacteria,2U19D@28211|Alphaproteobacteria,2JPXQ@204441|Rhodospirillales	204441|Rhodospirillales	T	COG0639 Diadenosine tetraphosphatase and related serine threonine protein phosphatases	-	-	3.1.3.16	ko:K07313	-	-	-	-	ko00000,ko01000	-	-	-	-
k59_1727095_1	665571.STHERM_c03280	5e-23	101.0	COG0143@1|root,COG0143@2|Bacteria,2J699@203691|Spirochaetes	203691|Spirochaetes	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
k59_1115822_1	323848.Nmul_A1018	2.38e-87	283.0	COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,2VJYV@28216|Betaproteobacteria,373XN@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdop_Fe4S4,Molybdopterin,NADH-G_4Fe-4S_3
k59_895356_1	1121106.JQKB01000016_gene5355	1.15e-26	100.0	2AJ2R@1|root,319M2@2|Bacteria,1RJXB@1224|Proteobacteria,2UA6I@28211|Alphaproteobacteria,2JY06@204441|Rhodospirillales	204441|Rhodospirillales	S	Conserved hypothetical protein (Lin0512_fam)	-	-	-	-	-	-	-	-	-	-	-	-	Lin0512_fam
k59_895356_2	864069.MicloDRAFT_00055240	2.49e-51	168.0	COG0684@1|root,COG0684@2|Bacteria,1MUWV@1224|Proteobacteria,2TU1X@28211|Alphaproteobacteria,1JTAU@119045|Methylobacteriaceae	28211|Alphaproteobacteria	H	Aldolase/RraA	MA20_39210	-	-	-	-	-	-	-	-	-	-	-	RraA-like
k59_916151_1	1121033.AUCF01000012_gene850	1.16e-83	257.0	28I53@1|root,2Z88I@2|Bacteria,1NE5N@1224|Proteobacteria,2TTBB@28211|Alphaproteobacteria,2JSU5@204441|Rhodospirillales	204441|Rhodospirillales	S	Protein of unknown function (DUF3750)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3750
k59_80624_1	648757.Rvan_1571	1.66e-101	305.0	COG1305@1|root,COG1305@2|Bacteria,1MVMI@1224|Proteobacteria,2TRFC@28211|Alphaproteobacteria,3N6WJ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,Transglut_core
k59_471145_1	338966.Ppro_1578	3.2e-28	117.0	COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,42N50@68525|delta/epsilon subdivisions,2WJ23@28221|Deltaproteobacteria,43TM9@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SMC_N
k59_857852_1	1038867.AXAY01000028_gene4748	1.68e-92	284.0	COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria,3JTY7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_414382_1	1313172.YM304_22030	8.76e-42	150.0	COG0668@1|root,COG0668@2|Bacteria,2GMFK@201174|Actinobacteria	201174|Actinobacteria	M	mechanosensitive ion channel	mscS	-	-	ko:K22044	-	-	-	-	ko00000,ko02000	1.A.23.3	-	-	MS_channel
k59_1471104_1	1121441.AUCX01000009_gene2598	7.9e-21	94.0	COG4249@1|root,COG4249@2|Bacteria,1R3WZ@1224|Proteobacteria,43AG7@68525|delta/epsilon subdivisions,2X5W8@28221|Deltaproteobacteria,2MGYA@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Caspase domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14
k59_1359662_1	999423.HMPREF9161_00382	1.82e-27	112.0	COG1160@1|root,COG1160@2|Bacteria,1TPNM@1239|Firmicutes,4H2BC@909932|Negativicutes	909932|Negativicutes	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
k59_1359662_2	861299.J421_3236	2.6e-30	115.0	COG0344@1|root,COG0344@2|Bacteria,1ZTTW@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
k59_1414934_1	69279.BG36_05610	1.54e-13	72.4	COG5379@1|root,COG5379@2|Bacteria,1MWG8@1224|Proteobacteria,2TQKH@28211|Alphaproteobacteria,43I3I@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	I	S-adenosylmethionine diacylglycerol 3-amino-3-carboxypropyl transferase	btaA	-	-	ko:K13622	ko00564,map00564	-	R09072	RC00021,RC01091	ko00000,ko00001	-	-	-	DUF3419
k59_1414934_2	411470.RUMGNA_03910	1.22e-18	85.9	COG0688@1|root,COG0688@2|Bacteria,1TR34@1239|Firmicutes,248VU@186801|Clostridia,3XYYF@572511|Blautia	186801|Clostridia	I	Phosphatidylserine decarboxylase	psd	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
k59_191553_1	1045855.DSC_14095	8.44e-42	153.0	COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,1RNB8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
k59_857870_1	1237149.C900_05603	1.42e-30	118.0	COG0500@1|root,COG2226@2|Bacteria,4NE6P@976|Bacteroidetes,47K6K@768503|Cytophagia	976|Bacteroidetes	Q	Methyltransferase domain	rebM	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_303348_1	1492738.FEM21_26900	1.55e-28	113.0	COG0657@1|root,COG3940@1|root,COG0657@2|Bacteria,COG3940@2|Bacteria,4NH62@976|Bacteroidetes,1HYAU@117743|Flavobacteriia,2NUG1@237|Flavobacterium	976|Bacteroidetes	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,Glyco_hydro_43,Peptidase_S9
k59_303348_2	143224.JQMD01000002_gene400	2.25e-19	85.9	COG0451@1|root,COG0451@2|Bacteria,4NGJ6@976|Bacteroidetes,1HZK8@117743|Flavobacteriia	976|Bacteroidetes	GM	NAD dependent epimerase/dehydratase family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
k59_803662_1	926559.JoomaDRAFT_3456	1.83e-83	255.0	COG1028@1|root,COG1028@2|Bacteria,4NH6Y@976|Bacteroidetes,1HXA4@117743|Flavobacteriia	976|Bacteroidetes	IQ	short-chain dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_1636287_1	515635.Dtur_0805	3.22e-71	226.0	COG0216@1|root,COG0216@2|Bacteria	2|Bacteria	J	translation release factor activity	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
k59_1581913_1	63737.Npun_F1222	1.8e-64	222.0	COG1672@1|root,COG2319@1|root,COG1672@2|Bacteria,COG2319@2|Bacteria,1FZVW@1117|Cyanobacteria,1HINJ@1161|Nostocales	1117|Cyanobacteria	L	PFAM WD domain, G-beta repeat	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14,WD40
k59_247223_1	489825.LYNGBM3L_21190	1.41e-81	253.0	COG0438@1|root,COG0438@2|Bacteria,1GC2Y@1117|Cyanobacteria	1117|Cyanobacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1137831_1	931277.C448_02908	3.14e-27	109.0	COG1028@1|root,arCOG01259@2157|Archaea,2XV6B@28890|Euryarchaeota,23SBJ@183963|Halobacteria	183963|Halobacteria	I	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_25369_1	861299.J421_1843	3.91e-97	299.0	COG1233@1|root,COG1233@2|Bacteria,1ZSTQ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	Q	Flavin containing amine oxidoreductase	-	-	1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31	ko:K10027	ko00906,ko01100,ko01110,map00906,map01100,map01110	-	R04787,R04798,R04800,R09691,R09692	RC01214,RC02088,RC02605	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase
k59_25369_2	316057.RPD_3271	2.48e-09	56.6	COG0517@1|root,COG0517@2|Bacteria,1N0H3@1224|Proteobacteria,2UC0F@28211|Alphaproteobacteria,3JY3F@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Domain in cystathionine beta-synthase and other proteins.	MA20_31615	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_1081409_1	1123072.AUDH01000047_gene1767	3.98e-07	51.2	COG1366@1|root,COG1366@2|Bacteria	2|Bacteria	T	antisigma factor binding	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS,STAS_2
k59_1081409_2	99598.Cal7507_6086	2.95e-19	84.0	COG3548@1|root,COG3548@2|Bacteria,1GKP7@1117|Cyanobacteria,1HRK3@1161|Nostocales	1117|Cyanobacteria	S	Protein of unknown function (DUF1211)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1211
k59_580414_2	1293047.CBMA010000012_gene786	2.2e-35	132.0	COG2141@1|root,arCOG02410@2157|Archaea,2XV1C@28890|Euryarchaeota,23UXX@183963|Halobacteria	183963|Halobacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	1.14.14.35	ko:K17228	ko00920,map00920	-	R10203	RC02556,RC03080	ko00000,ko00001,ko01000	-	-	-	Bac_luciferase
k59_303391_2	290633.GOX1901	8.27e-42	139.0	COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,2U9AQ@28211|Alphaproteobacteria,2JSPE@204441|Rhodospirillales	204441|Rhodospirillales	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
k59_303391_3	1244869.H261_02186	5.39e-24	99.8	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,2TS07@28211|Alphaproteobacteria,2JPIQ@204441|Rhodospirillales	204441|Rhodospirillales	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
k59_1192822_1	314278.NB231_10398	2.58e-62	204.0	COG2718@1|root,COG2718@2|Bacteria,1MWQM@1224|Proteobacteria,1RQWC@1236|Gammaproteobacteria,1WWH8@135613|Chromatiales	135613|Chromatiales	S	Belongs to the UPF0229 family	-	-	-	ko:K09786	-	-	-	-	ko00000	-	-	-	DUF444
k59_1137853_1	1532558.JL39_24075	3.27e-10	67.4	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,2TSR0@28211|Alphaproteobacteria,4B8Z0@82115|Rhizobiaceae	28211|Alphaproteobacteria	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
k59_1250095_1	379066.GAU_2568	2.98e-84	262.0	COG1459@1|root,COG1459@2|Bacteria,1ZT63@142182|Gemmatimonadetes	142182|Gemmatimonadetes	U	Type II secretion system (T2SS), protein F	-	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
k59_1359721_1	1333998.M2A_3001	1.33e-45	163.0	COG0475@1|root,COG0475@2|Bacteria,1QTSD@1224|Proteobacteria,2TW8J@28211|Alphaproteobacteria,4BTG0@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	P	Sodium/hydrogen exchanger family	-	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger,TrkA_N
k59_525637_1	631454.N177_4103	2.95e-92	278.0	COG2358@1|root,COG2358@2|Bacteria,1MXW1@1224|Proteobacteria,2UEZT@28211|Alphaproteobacteria,1JPP3@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	NMT1-like family	-	-	-	-	-	-	-	-	-	-	-	-	NMT1_3
k59_1304191_1	1238425.J07HQW2_01370	6.84e-26	108.0	COG0141@1|root,arCOG04352@2157|Archaea,2XT6M@28890|Euryarchaeota,23SH9@183963|Halobacteria	183963|Halobacteria	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
k59_748078_1	375286.mma_1977	1.95e-93	284.0	COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,2VHW4@28216|Betaproteobacteria,4725J@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
k59_803733_1	935837.JAEK01000050_gene943	6.68e-28	115.0	COG2265@1|root,COG2265@2|Bacteria,1TP4H@1239|Firmicutes,4HA6M@91061|Bacilli,1ZB9G@1386|Bacillus	91061|Bacilli	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	rlmCD	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070041,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
k59_580455_1	1089550.ATTH01000001_gene269	7.29e-60	199.0	COG0508@1|root,COG0508@2|Bacteria,4NFB9@976|Bacteroidetes,1FIKE@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhC	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_1581992_1	1380370.JIBA01000013_gene1291	1.07e-36	140.0	COG0514@1|root,COG0514@2|Bacteria,2GJSS@201174|Actinobacteria,4FGIU@85021|Intrasporangiaceae	201174|Actinobacteria	L	RecQ zinc-binding	-	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,DUF3553,Helicase_C,RecQ_Zn_bind
k59_1747984_1	234267.Acid_4623	8.21e-30	119.0	COG4447@1|root,COG4447@2|Bacteria,3Y2SN@57723|Acidobacteria	57723|Acidobacteria	S	Sortilin, neurotensin receptor 3,	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
k59_525694_1	1122939.ATUD01000005_gene2655	1.45e-43	154.0	COG4974@1|root,COG4974@2|Bacteria,2GNDP@201174|Actinobacteria,4CQMQ@84995|Rubrobacteria	84995|Rubrobacteria	L	Phage integrase, N-terminal SAM-like domain	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_748125_1	263820.PTO1075	1.44e-27	116.0	COG0028@1|root,arCOG01998@2157|Archaea,2XT5F@28890|Euryarchaeota,24201@183967|Thermoplasmata	183967|Thermoplasmata	E	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_580487_2	1121935.AQXX01000089_gene4656	7.39e-126	362.0	COG0655@1|root,COG0655@2|Bacteria,1N5Q7@1224|Proteobacteria,1RY1K@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	COG0655 Multimeric flavodoxin WrbA	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
k59_803772_1	311403.Arad_0768	4.68e-20	95.9	COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,2TQU1@28211|Alphaproteobacteria,4B823@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	probably responsible for the translocation of the substrate across the membrane	pstC	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1,DUF3708
k59_971092_1	269084.syc2336_d	1.11e-97	303.0	COG0591@1|root,COG0591@2|Bacteria,1G1JV@1117|Cyanobacteria,1GZ33@1129|Synechococcus	1117|Cyanobacteria	P	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	putP	-	-	-	-	-	-	-	-	-	-	-	SSF
k59_1582044_1	1160718.SU9_33003	1.39e-54	184.0	COG0436@1|root,COG0436@2|Bacteria,2I8Z8@201174|Actinobacteria	201174|Actinobacteria	E	aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
k59_136012_1	880073.Calab_1189	3.75e-86	263.0	COG0468@1|root,COG0468@2|Bacteria,2NNYW@2323|unclassified Bacteria	2|Bacteria	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009292,GO:0009294,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0030420,GO:0031668,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0044764,GO:0046483,GO:0050896,GO:0051704,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:1901360	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
k59_803801_1	608538.HTH_1717	5.14e-107	338.0	COG0243@1|root,COG0243@2|Bacteria,2G51K@200783|Aquificae	200783|Aquificae	C	Molybdopterin oxidoreductase	-	-	1.7.5.1	ko:K00370,ko:K17050	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000,ko02000	5.A.3.1,5.A.3.8	-	-	Molybdopterin,Molydop_binding
k59_916379_2	926569.ANT_07040	1.32e-63	205.0	COG1363@1|root,COG1363@2|Bacteria	2|Bacteria	G	aminopeptidase activity	yhfE	-	3.2.1.4	ko:K01179,ko:K01269	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Peptidase_M42
k59_1415096_1	357808.RoseRS_1548	6.87e-37	139.0	COG1012@1|root,COG1012@2|Bacteria,2G61H@200795|Chloroflexi,374XS@32061|Chloroflexia	32061|Chloroflexia	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.88	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	-	R00245,R00707,R00708,R04444,R04445,R05051	RC00080,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000	-	-	-	Aldedh
k59_1192941_1	1121272.KB903250_gene3134	5.37e-16	83.2	COG0477@1|root,COG2814@2|Bacteria,2GJU2@201174|Actinobacteria,4D9HH@85008|Micromonosporales	201174|Actinobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
k59_471358_1	1121271.AUCM01000024_gene2685	1.86e-115	338.0	COG2358@1|root,COG2358@2|Bacteria,1MXW1@1224|Proteobacteria,2TSK2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	TRAP transporter solute receptor TAXI family	imp	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
k59_303537_1	61273.S3BXA8	1.88e-07	58.2	2CNHS@1|root,2QWE4@2759|Eukaryota,38GY7@33154|Opisthokonta,3NY50@4751|Fungi,3QNF0@4890|Ascomycota,216QA@147550|Sordariomycetes,3UUVX@5151|Ophiostomatales	4751|Fungi	G	Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain	-	-	-	-	-	-	-	-	-	-	-	-	Bac_rhamnosid6H,Bac_rhamnosid_C
k59_1359842_1	395493.BegalDRAFT_2059	2.66e-65	221.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,1RM7J@1236|Gammaproteobacteria,45ZWK@72273|Thiotrichales	72273|Thiotrichales	M	TIGRFAM penicillin-binding protein, 1A	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	PCB_OB,Transgly,Transpeptidase
k59_693075_1	1245469.S58_69210	2.72e-108	323.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2TSA7@28211|Alphaproteobacteria,3JTRC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_1748067_1	861299.J421_4185	1.24e-88	274.0	COG0304@1|root,COG0304@2|Bacteria,1ZTE1@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_971137_1	56107.Cylst_5868	1.52e-25	108.0	COG1357@1|root,COG1357@2|Bacteria,1GHTS@1117|Cyanobacteria,1HMT8@1161|Nostocales	1117|Cyanobacteria	S	PFAM Pentapeptide	-	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide
k59_803832_1	1121101.HMPREF1532_01505	1.68e-24	103.0	COG0793@1|root,COG0793@2|Bacteria,4NFEN@976|Bacteroidetes,2FMMP@200643|Bacteroidia,4AKWW@815|Bacteroidaceae	976|Bacteroidetes	M	peptidase S41	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S41,Tricorn_C1
k59_858050_1	351348.Maqu_1721	2.17e-96	291.0	COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,1RNB3@1236|Gammaproteobacteria,46BCB@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	Transposase, Mutator family	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_193637_1	330214.NIDE0993	2.39e-57	188.0	COG0501@1|root,COG0501@2|Bacteria	2|Bacteria	O	metalloendopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
k59_1695708_1	1317118.ATO8_21461	6e-86	265.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,4KNPA@93682|Roseivivax	28211|Alphaproteobacteria	L	Transposase IS116/IS110/IS902 family	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1029314_1	1294265.JCM21738_3419	5.11e-55	184.0	COG0334@1|root,COG0334@2|Bacteria,1TQU2@1239|Firmicutes,4HAB2@91061|Bacilli,1ZB55@1386|Bacillus	91061|Bacilli	E	Belongs to the Glu Leu Phe Val dehydrogenases family	ldh	-	1.4.1.9	ko:K00263	ko00280,ko00290,ko01100,ko01110,ko01130,map00280,map00290,map01100,map01110,map01130	-	R01088,R01434,R02196	RC00006,RC00036	ko00000,ko00001,ko01000	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
k59_1029314_2	986075.CathTA2_2820	9.17e-59	193.0	COG0112@1|root,COG0112@2|Bacteria,1TQVM@1239|Firmicutes,4HA5K@91061|Bacilli	91061|Bacilli	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
k59_972970_1	1124780.ANNU01000008_gene2767	1.14e-05	55.5	COG0642@1|root,COG3829@1|root,COG5002@1|root,COG2205@2|Bacteria,COG3829@2|Bacteria,COG5002@2|Bacteria,4NDXU@976|Bacteroidetes,47JK3@768503|Cytophagia	976|Bacteroidetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
k59_527539_1	797114.C475_00295	6.81e-05	49.3	28I5K@1|root,2N5U5@2157|Archaea,2XX25@28890|Euryarchaeota,23VXZ@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_972981_1	1333998.M2A_2719	5.52e-92	286.0	COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria,2TR5C@28211|Alphaproteobacteria,4BRV7@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	PFAM Membrane dipeptidase (Peptidase family M19)	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
k59_137772_1	316274.Haur_2046	1.47e-62	204.0	COG0517@1|root,COG0517@2|Bacteria	2|Bacteria	S	IMP dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
k59_137772_2	1349822.NSB1T_00175	3.04e-13	69.7	COG4974@1|root,COG4974@2|Bacteria,4NE0E@976|Bacteroidetes,2FP3B@200643|Bacteroidia,22WQE@171551|Porphyromonadaceae	976|Bacteroidetes	D	Belongs to the 'phage' integrase family. XerC subfamily	xerC	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_859830_1	868595.Desca_0165	1.35e-70	223.0	COG1521@1|root,COG1521@2|Bacteria,1TR0X@1239|Firmicutes,248PX@186801|Clostridia,260RP@186807|Peptococcaceae	186801|Clostridia	F	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Pan_kinase
k59_712772_2	765420.OSCT_1682	4.72e-58	187.0	COG3222@1|root,COG3222@2|Bacteria	2|Bacteria	S	Uncharacterized protein conserved in bacteria (DUF2064)	-	-	-	ko:K09931	-	-	-	-	ko00000	-	-	-	DUF2064
k59_43079_1	1284352.AOIG01000008_gene2441	1.99e-06	55.1	COG0747@1|root,COG0747@2|Bacteria,1TQ0N@1239|Firmicutes,4HARF@91061|Bacilli,26QIY@186822|Paenibacillaceae	91061|Bacilli	E	ABC transporter substrate-binding protein	oppA1	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_1379220_2	1033734.CAET01000082_gene3395	2.16e-58	191.0	COG0084@1|root,COG0084@2|Bacteria,1TNY1@1239|Firmicutes,4HA74@91061|Bacilli,1ZB78@1386|Bacillus	91061|Bacilli	L	hydrolase, TatD	tatD	GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
k59_1157078_1	1333998.M2A_2883	7.2e-12	68.6	COG3509@1|root,COG3509@2|Bacteria,1N6M6@1224|Proteobacteria,2U39G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Esterase PHB depolymerase	-	-	-	ko:K03932	-	-	-	-	ko00000	-	CE1	-	Abhydrolase_2,Esterase_phd
k59_990807_1	485913.Krac_6264	2.42e-38	142.0	COG3547@1|root,COG3547@2|Bacteria,2G92P@200795|Chloroflexi	200795|Chloroflexi	L	PFAM transposase IS116 IS110 IS902 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_544217_1	450851.PHZ_c0019	0.000425	48.1	COG3118@1|root,COG3118@2|Bacteria,1MV0R@1224|Proteobacteria,2TS5X@28211|Alphaproteobacteria,2KF1N@204458|Caulobacterales	204458|Caulobacterales	O	Thioredoxin	-	-	-	ko:K05838	-	-	-	-	ko00000,ko03110	-	-	-	TPR_19,TPR_20,Thioredoxin
k59_1601257_1	1122604.JONR01000032_gene66	7.21e-50	161.0	COG2164@1|root,COG2164@2|Bacteria,1N81P@1224|Proteobacteria,1SU9C@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Cyclophilin-like	-	-	-	ko:K09143	-	-	-	-	ko00000	-	-	-	Cyclophil_like
k59_43120_1	1173264.KI913949_gene2050	3.87e-27	110.0	2DBFF@1|root,2Z8YA@2|Bacteria,1G2KB@1117|Cyanobacteria	1117|Cyanobacteria	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_4,HTH_Tnp_4
k59_1047040_1	304371.MCP_1475	6.99e-33	120.0	COG1611@1|root,arCOG02431@2157|Archaea,2XXME@28890|Euryarchaeota	28890|Euryarchaeota	S	Possible lysine decarboxylase	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
k59_432994_2	366394.Smed_5146	1.27e-06	50.4	COG0484@1|root,COG0484@2|Bacteria,1MUZ4@1224|Proteobacteria,2TR01@28211|Alphaproteobacteria,4B8Z7@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	DnaJ C terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ,DnaJ_C
k59_1324578_1	762376.AXYL_03971	1.36e-37	133.0	COG0740@1|root,COG0740@2|Bacteria,1MV46@1224|Proteobacteria,2VHAZ@28216|Betaproteobacteria,3T1MR@506|Alcaligenaceae	28216|Betaproteobacteria	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
k59_1324578_2	861299.J421_3856	2.24e-83	258.0	COG1219@1|root,COG1219@2|Bacteria,1ZT8F@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
k59_323610_1	926569.ANT_23780	1.69e-123	367.0	COG1388@1|root,COG2340@1|root,COG1388@2|Bacteria,COG2340@2|Bacteria,2G9SX@200795|Chloroflexi	200795|Chloroflexi	M	Cysteine-rich secretory protein family	-	-	-	-	-	-	-	-	-	-	-	-	CAP,LysM
k59_154817_1	1089552.KI911559_gene190	1.43e-70	231.0	COG4191@1|root,COG4191@2|Bacteria,1MVK7@1224|Proteobacteria,2TR44@28211|Alphaproteobacteria,2JQ26@204441|Rhodospirillales	204441|Rhodospirillales	T	Signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
k59_712858_1	1379698.RBG1_1C00001G0288	7.78e-18	77.0	COG0234@1|root,COG0234@2|Bacteria,2NPW2@2323|unclassified Bacteria	2|Bacteria	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010033,GO:0016032,GO:0016465,GO:0019058,GO:0019068,GO:0032991,GO:0035966,GO:0042221,GO:0042802,GO:0043167,GO:0043169,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051704,GO:0061077,GO:0101031,GO:1990220	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
k59_712858_2	1307759.JOMJ01000003_gene1878	6.11e-39	143.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,42M52@68525|delta/epsilon subdivisions,2WIRK@28221|Deltaproteobacteria,2M84Y@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
k59_154819_1	102125.Xen7305DRAFT_00028620	2.68e-19	88.2	COG3547@1|root,COG3547@2|Bacteria,1G077@1117|Cyanobacteria,3VNMH@52604|Pleurocapsales	1117|Cyanobacteria	L	Transposase IS116/IS110/IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1047060_1	357808.RoseRS_1604	1.07e-38	141.0	COG3570@1|root,COG3570@2|Bacteria,2G7VJ@200795|Chloroflexi	200795|Chloroflexi	H	PFAM aminoglycoside hydroxyurea antibiotic resistance kinase	-	-	2.7.1.72	ko:K04343	-	M00766	R02225	RC00002,RC00078	br01600,ko00000,ko00002,ko01000,ko01504	-	-	-	APH_6_hur
k59_99708_1	555079.Toce_1845	9.39e-11	67.0	COG2204@1|root,COG2204@2|Bacteria,1VSKG@1239|Firmicutes,24ZP4@186801|Clostridia,42J66@68295|Thermoanaerobacterales	186801|Clostridia	T	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	ko:K02481,ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1324610_1	1283283.ATXA01000002_gene2800	5.73e-18	86.7	COG1597@1|root,COG1597@2|Bacteria,2GJ3K@201174|Actinobacteria,4ET26@85013|Frankiales	201174|Actinobacteria	I	PFAM Diacylglycerol kinase, catalytic	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
k59_1433964_1	1379698.RBG1_1C00001G0508	1.5e-38	140.0	COG0183@1|root,COG0183@2|Bacteria,2NNU9@2323|unclassified Bacteria	2|Bacteria	I	Belongs to the thiolase family	bktB	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K07508	ko00062,ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00062,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00085,M00087,M00088,M00095,M00373,M00374,M00375	R00238,R00391,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747	RC00004,RC00326,RC00405,RC01702	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_491113_1	682795.AciX8_1452	2.9e-12	70.1	COG4675@1|root,COG4675@2|Bacteria,3Y4U8@57723|Acidobacteria,2JJF5@204432|Acidobacteriia	204432|Acidobacteriia	S	Tail Collar	-	-	-	-	-	-	-	-	-	-	-	-	Collar
k59_936799_1	352165.HMPREF7215_2591	2.68e-06	56.2	COG5410@1|root,COG5410@2|Bacteria	2|Bacteria	K	chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_6,Terminase_6C
k59_1324629_1	1313172.YM304_11970	8.19e-57	194.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4CNI7@84992|Acidimicrobiia	84992|Acidimicrobiia	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_323652_1	1089552.KI911559_gene234	6.59e-99	299.0	COG3572@1|root,COG3572@2|Bacteria,1MU47@1224|Proteobacteria,2TRPT@28211|Alphaproteobacteria,2JPAV@204441|Rhodospirillales	204441|Rhodospirillales	H	glutamate--cysteine ligase	gshA	-	6.3.2.2	ko:K01919	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00894,R10993	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	GCS2
k59_766081_1	886293.Sinac_0821	2.38e-29	121.0	COG0589@1|root,COG1914@1|root,COG0589@2|Bacteria,COG1914@2|Bacteria,2J0SG@203682|Planctomycetes	203682|Planctomycetes	P	Natural resistance-associated macrophage protein	mntH	-	-	ko:K03322	-	-	-	-	ko00000,ko02000	2.A.55.2.6,2.A.55.3	-	-	Nramp
k59_936810_1	767817.Desgi_4251	1.25e-60	211.0	COG0574@1|root,COG0587@1|root,COG3848@1|root,COG0574@2|Bacteria,COG0587@2|Bacteria,COG3848@2|Bacteria,1UIEA@1239|Firmicutes,25EJM@186801|Clostridia,260AR@186807|Peptococcaceae	186801|Clostridia	GT	Pyruvate phosphate dikinase, PEP	ppdK	-	2.7.9.1,2.7.9.2	ko:K01006,ko:K01007	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173,M00374	R00199,R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_377870_1	1123373.ATXI01000015_gene1222	1.47e-08	58.2	2DMB6@1|root,32FKI@2|Bacteria,2GI5C@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Nucleotidyl transferase AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii
k59_264989_1	211165.AJLN01000056_gene2903	1.54e-30	117.0	COG0842@1|root,COG0842@2|Bacteria,1G1BS@1117|Cyanobacteria,1JIEV@1189|Stigonemataceae	1117|Cyanobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
k59_990903_1	1254432.SCE1572_46550	5.27e-51	172.0	COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,42MV9@68525|delta/epsilon subdivisions,2WJZK@28221|Deltaproteobacteria,2YTSB@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_0016	URO-D
k59_1101094_1	1173029.JH980292_gene2741	0.000318	50.1	COG0642@1|root,COG2205@2|Bacteria,1G0M5@1117|Cyanobacteria,1H7J8@1150|Oscillatoriales	1117|Cyanobacteria	T	May be involved in signal transduction. Participates in the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria, via its interaction with KaiC. Required for robustness of the circadian rhythm of gene expression and is involved in clock outputs	sasA	GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0035556,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071704,GO:0140096,GO:1901564	2.7.13.3	ko:K08479	ko02020,map02020	M00467	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,KaiB
k59_208839_1	1177181.T9A_00077	5.79e-103	314.0	COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,1RMYA@1236|Gammaproteobacteria,1XHAH@135619|Oceanospirillales	135619|Oceanospirillales	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,Pribosyltran
k59_990911_1	671143.DAMO_1500	1.88e-16	78.6	COG3808@1|root,COG3808@2|Bacteria,2NNK9@2323|unclassified Bacteria	2|Bacteria	C	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
k59_990911_2	1254432.SCE1572_41165	2.22e-39	140.0	COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,42S9C@68525|delta/epsilon subdivisions,2WM4G@28221|Deltaproteobacteria,2YU8Y@29|Myxococcales	28221|Deltaproteobacteria	Q	Dienelactone hydrolase family	dlhH2	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
k59_377908_1	1219049.SP5_043_00940	3.78e-17	85.5	COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,2TRXK@28211|Alphaproteobacteria,2K12N@204457|Sphingomonadales	204457|Sphingomonadales	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
k59_712977_1	671143.DAMO_0533	1.1e-84	280.0	COG0086@1|root,COG0086@2|Bacteria,2NNPR@2323|unclassified Bacteria	2|Bacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.6	ko:K03046,ko:K13797	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_877683_1	1278078.G419_11417	2.82e-10	65.5	COG2120@1|root,COG2120@2|Bacteria,2GKUM@201174|Actinobacteria,4FUV2@85025|Nocardiaceae	201174|Actinobacteria	S	Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway	mshB	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006790,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0010125,GO:0010126,GO:0016020,GO:0016137,GO:0016138,GO:0016787,GO:0016810,GO:0016811,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044272,GO:0044464,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659	3.5.1.103	ko:K15525	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
k59_1766071_1	378806.STAUR_7567	4.76e-16	79.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria	1224|Proteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
k59_208870_2	926550.CLDAP_06850	1.53e-30	113.0	COG5319@1|root,COG5319@2|Bacteria,2GA9G@200795|Chloroflexi	200795|Chloroflexi	S	Putative regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
k59_1270027_1	305700.B447_06020	3.23e-21	96.3	COG0797@1|root,COG3087@1|root,COG0797@2|Bacteria,COG3087@2|Bacteria,1MZ8S@1224|Proteobacteria,2VJAN@28216|Betaproteobacteria,2KUPW@206389|Rhodocyclales	206389|Rhodocyclales	DM	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	rlpA	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1,SPOR
k59_99830_1	926550.CLDAP_10720	6.32e-49	176.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,2G65G@200795|Chloroflexi	200795|Chloroflexi	I	3-hydroxyacyl-CoA dehydrogenase domain protein	-	-	1.1.1.35	ko:K07516	ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212	M00087	R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1,ECH_2
k59_1601390_1	936455.KI421499_gene3206	8.89e-13	73.9	COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,3JTQ7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DZR,Guanylate_cyc,SAM_1
k59_433143_1	565034.BHWA1_02134	6.92e-24	93.2	COG0093@1|root,COG0093@2|Bacteria,2J7N1@203691|Spirochaetes	203691|Spirochaetes	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	-	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
k59_433143_2	926569.ANT_10150	5.15e-51	163.0	COG0198@1|root,COG0198@2|Bacteria,2G750@200795|Chloroflexi	200795|Chloroflexi	J	One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplX	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
k59_154959_1	1167006.UWK_02689	6.07e-07	56.6	COG1716@1|root,COG1716@2|Bacteria	2|Bacteria	T	histone H2A K63-linked ubiquitination	-	-	-	-	-	-	-	-	-	-	-	-	EAL,FHA,GerE,Yop-YscD_cpl
k59_208892_2	402881.Plav_0574	8.85e-09	55.5	2EGDK@1|root,31BUJ@2|Bacteria,1Q7SS@1224|Proteobacteria,2UUEB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_99850_1	679200.HMPREF9333_01321	4.71e-07	52.4	COG4965@1|root,COG4965@2|Bacteria,1UZ3V@1239|Firmicutes,25D46@186801|Clostridia	186801|Clostridia	U	type II secretion system	-	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
k59_822499_1	454957.IA64_17605	3.35e-83	254.0	COG4760@1|root,COG4760@2|Bacteria,1REUF@1224|Proteobacteria,1S3R1@1236|Gammaproteobacteria,1XD47@135614|Xanthomonadales	135614|Xanthomonadales	S	Inhibitor of apoptosis-promoting Bax1	-	-	-	-	-	-	-	-	-	-	-	-	BaxI_1
k59_1766119_1	1211115.ALIQ01000043_gene2966	4.34e-77	238.0	COG2998@1|root,COG2998@2|Bacteria,1MVSF@1224|Proteobacteria,2TU33@28211|Alphaproteobacteria,3NAEA@45404|Beijerinckiaceae	28211|Alphaproteobacteria	H	PBP superfamily domain	tupA	-	-	ko:K05772	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	PBP_like_2
k59_938900_1	1043205.AFYF01000065_gene2151	2.42e-50	166.0	COG3467@1|root,COG3467@2|Bacteria,2HGVK@201174|Actinobacteria,4FGIE@85021|Intrasporangiaceae	201174|Actinobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
k59_1492943_1	33876.JNXY01000005_gene8773	1.4e-08	59.3	COG1011@1|root,COG1011@2|Bacteria	2|Bacteria	S	phosphatase activity	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
k59_435159_2	1410630.JNKP01000001_gene2445	4.8e-38	143.0	COG0480@1|root,COG0480@2|Bacteria,1TPF9@1239|Firmicutes,247VN@186801|Clostridia,27IQF@186928|unclassified Lachnospiraceae	186801|Clostridia	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_546460_1	713586.KB900536_gene1690	1.5e-31	127.0	COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1WWZQ@135613|Chromatiales	135613|Chromatiales	T	response regulator receiver	-	-	-	ko:K02487,ko:K06596	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg
k59_380010_1	1231391.AMZF01000067_gene3428	1.76e-60	205.0	COG0318@1|root,COG0318@2|Bacteria,1MUQZ@1224|Proteobacteria,2VIB6@28216|Betaproteobacteria	28216|Betaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.34	ko:K12508	-	-	-	-	ko00000,ko01000	-	-	-	AMP-binding
k59_1657105_1	887929.HMP0721_0046	1.85e-29	114.0	COG3938@1|root,COG3938@2|Bacteria,1TQ61@1239|Firmicutes,2487S@186801|Clostridia,25Y7Y@186806|Eubacteriaceae	186801|Clostridia	E	Proline racemase	-	-	5.1.1.4	ko:K01777	ko00330,ko01100,map00330,map01100	-	R01255	RC00479	ko00000,ko00001,ko01000	-	-	-	Pro_racemase
k59_1160038_1	1283299.AUKG01000002_gene5220	5.81e-12	67.8	COG1595@1|root,COG1595@2|Bacteria,2GMRK@201174|Actinobacteria,4CRR4@84995|Rubrobacteria	84995|Rubrobacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	NTF2,Sigma70_r2,Sigma70_r4_2,SnoaL_2
k59_210768_1	204669.Acid345_0596	9.41e-32	127.0	COG0497@1|root,COG0497@2|Bacteria,3Y2J4@57723|Acidobacteria,2JI9C@204432|Acidobacteriia	204432|Acidobacteriia	L	May be involved in recombinational repair of damaged DNA	-	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	SMC_N
k59_655584_1	518766.Rmar_1266	1.39e-30	119.0	COG1024@1|root,COG1024@2|Bacteria,4NI32@976|Bacteroidetes,1FIVI@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.2.1.18	ko:K13766	ko00280,ko01100,map00280,map01100	M00036	R02085	RC02416	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
k59_210769_2	1519464.HY22_11525	6.13e-25	103.0	COG0477@1|root,COG2814@2|Bacteria,1FD9X@1090|Chlorobi	1090|Chlorobi	EGP	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_2,Sugar_tr
k59_938942_1	715226.ABI_04170	1.47e-22	97.1	COG2740@1|root,COG2740@2|Bacteria,1RHPR@1224|Proteobacteria,2U9RY@28211|Alphaproteobacteria,2KGI2@204458|Caulobacterales	204458|Caulobacterales	K	Protein of unknown function (DUF448)	-	-	-	ko:K07742	-	-	-	-	ko00000	-	-	-	DUF448,Ribosomal_L7Ae
k59_1272231_1	246197.MXAN_3555	1.21e-57	194.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2YU4Y@29|Myxococcales	28221|Deltaproteobacteria	T	Two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_938952_1	313625.BL107_13000	9.49e-57	200.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1G0PS@1117|Cyanobacteria,1GZKK@1129|Synechococcus	1117|Cyanobacteria	H	Methionine synthase	metH	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019752,GO:0032259,GO:0042084,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_1160073_1	290399.Arth_0510	1.66e-77	241.0	COG1071@1|root,COG1071@2|Bacteria,2IBRC@201174|Actinobacteria,1WAV4@1268|Micrococcaceae	201174|Actinobacteria	C	Dehydrogenase E1 component	pdhA	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
k59_1160073_2	43759.JNWK01000009_gene5023	4.84e-24	99.0	COG0022@1|root,COG0022@2|Bacteria,2GKFE@201174|Actinobacteria	201174|Actinobacteria	C	Pyruvate 2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit	-	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
k59_1668601_1	685778.AORL01000021_gene434	1.2e-29	117.0	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2U4WG@28211|Alphaproteobacteria,2K1X8@204457|Sphingomonadales	204457|Sphingomonadales	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_111961_1	765914.ThisiDRAFT_0946	1.48e-48	158.0	COG0080@1|root,COG0080@2|Bacteria,1RA2M@1224|Proteobacteria,1S22R@1236|Gammaproteobacteria,1WXZD@135613|Chromatiales	135613|Chromatiales	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	-	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
k59_111961_2	519989.ECTPHS_13238	4.23e-25	99.8	COG0081@1|root,COG0081@2|Bacteria,1MUE6@1224|Proteobacteria,1RMDW@1236|Gammaproteobacteria,1WW17@135613|Chromatiales	135613|Chromatiales	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
k59_445541_1	1125863.JAFN01000001_gene1632	5.38e-25	106.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,42Z38@68525|delta/epsilon subdivisions,2X5H0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_445541_2	592015.HMPREF1705_02010	0.000235	44.3	COG0601@1|root,COG0601@2|Bacteria,3TAD4@508458|Synergistetes	508458|Synergistetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_445544_1	344747.PM8797T_03690	1.01e-98	298.0	COG0189@1|root,COG0189@2|Bacteria,2IYT1@203682|Planctomycetes	203682|Planctomycetes	HJ	COG0189 Glutathione synthase Ribosomal protein S6 modification	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016874,GO:0016879,GO:0016881,GO:0018169,GO:0018410,GO:0019538,GO:0031668,GO:0033554,GO:0036211,GO:0043170,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0070739,GO:0071496,GO:0071704,GO:0140096,GO:1901564	-	ko:K05844	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	RimK,TrkA_C
k59_723556_1	756067.MicvaDRAFT_0393	1.8e-69	220.0	COG1215@1|root,COG1215@2|Bacteria,1GQXM@1117|Cyanobacteria,1HI49@1150|Oscillatoriales	1117|Cyanobacteria	M	Glycosyl transferase family 21	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_223126_1	1121472.AQWN01000004_gene720	1.37e-45	155.0	COG1250@1|root,COG1250@2|Bacteria,1TPA4@1239|Firmicutes,24DBH@186801|Clostridia,263NE@186807|Peptococcaceae	186801|Clostridia	I	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
k59_223126_2	1121938.AUDY01000009_gene2384	5.04e-12	65.5	COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,4HBW0@91061|Bacilli,3NEF0@45667|Halobacillus	91061|Bacilli	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
k59_1501832_1	1333856.L686_04500	9.1e-98	320.0	COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,1RSNV@1236|Gammaproteobacteria,1Z0YX@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	L	helicase	lhr	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,HTH_42,Helicase_C
k59_1335053_2	1158292.JPOE01000005_gene1018	1.89e-16	75.5	COG2030@1|root,COG2030@2|Bacteria,1RIBV@1224|Proteobacteria,2VTGX@28216|Betaproteobacteria,1KKWK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
k59_1057068_1	391619.PGA1_c23130	4.25e-67	219.0	COG0006@1|root,COG0006@2|Bacteria,1MVX5@1224|Proteobacteria,2TRMK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Xaa-Pro aminopeptidase	-	-	3.4.13.9	ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
k59_1223904_1	1042377.AFPJ01000051_gene75	1.8e-75	238.0	COG4927@1|root,COG4927@2|Bacteria,1NBGP@1224|Proteobacteria	1224|Proteobacteria	S	Acyl-coenzyme A 6-aminopenicillanic acid acyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_556704_1	502025.Hoch_4684	1.43e-44	165.0	COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,42Q75@68525|delta/epsilon subdivisions,2WMDY@28221|Deltaproteobacteria,2YU11@29|Myxococcales	28221|Deltaproteobacteria	L	DEAD DEAH box	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
k59_278736_1	402777.KB235904_gene4743	9.69e-134	402.0	COG3957@1|root,COG3957@2|Bacteria,1G0B2@1117|Cyanobacteria,1H7CT@1150|Oscillatoriales	1117|Cyanobacteria	G	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase	-	-	4.1.2.22,4.1.2.9	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120	-	R00761,R01621	RC00032,RC00226	ko00000,ko00001,ko01000	-	-	-	XFP,XFP_C,XFP_N
k59_1501849_1	1173021.ALWA01000031_gene2772	1.89e-19	88.2	COG1608@1|root,COG1608@2|Bacteria,1GBP5@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM aspartate glutamate uridylate kinase	-	-	-	-	-	-	-	-	-	-	-	-	AA_kinase
k59_167600_1	153721.MYP_3027	9.28e-81	268.0	COG1201@1|root,COG1201@2|Bacteria,4NGQ0@976|Bacteroidetes,47NAU@768503|Cytophagia	976|Bacteroidetes	L	DEAD DEAH box helicase	lhr	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
k59_667958_1	410358.Mlab_0129	4.18e-10	66.2	COG1690@1|root,arCOG04246@2157|Archaea,2XTIC@28890|Euryarchaeota,2N90W@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the RtcB family	rtcB	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
k59_1724228_1	1089544.KB912942_gene5082	9.92e-29	120.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria	2|Bacteria	K	ADP binding	-	GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016999,GO:0017000,GO:0017144,GO:0044237,GO:0044249	-	-	-	-	-	-	-	-	-	-	AAA_22,BTAD,NB-ARC,TPR_12,Trans_reg_C
k59_1112778_1	749414.SBI_01427	7.58e-13	72.4	COG1402@1|root,COG1402@2|Bacteria,2HCRK@201174|Actinobacteria	201174|Actinobacteria	S	Creatininase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
k59_723608_1	446471.Xcel_0466	5.72e-25	108.0	COG1169@1|root,COG1169@2|Bacteria,2GKE8@201174|Actinobacteria,4F44G@85017|Promicromonosporaceae	201174|Actinobacteria	HQ	chorismate binding enzyme	menF	-	5.4.4.2	ko:K02552	ko00130,ko01053,ko01100,ko01110,ko01130,map00130,map01053,map01100,map01110,map01130	M00116	R01717	RC00588	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_bind
k59_334352_1	314231.FP2506_13359	2.79e-55	183.0	COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,2TRZE@28211|Alphaproteobacteria,2PM1W@255475|Aurantimonadaceae	28211|Alphaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	ko:K21395	-	-	-	-	ko00000,ko02000	2.A.56.1	-	-	DctP
k59_834747_2	1304284.L21TH_0607	7.23e-40	138.0	COG2001@1|root,COG2001@2|Bacteria,1V3JD@1239|Firmicutes,24HB9@186801|Clostridia,36I1C@31979|Clostridiaceae	186801|Clostridia	K	Belongs to the MraZ family	mraZ	-	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
k59_1501876_1	754035.Mesau_01338	4.98e-82	256.0	COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,2TQWH@28211|Alphaproteobacteria,43HB0@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_56436_1	644966.Tmar_2185	9.62e-34	128.0	COG0443@1|root,COG0443@2|Bacteria,1TP1J@1239|Firmicutes,248QV@186801|Clostridia,3WCEV@538999|Clostridiales incertae sedis	186801|Clostridia	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
k59_56436_2	765420.OSCT_0150	8.94e-41	143.0	COG0576@1|root,COG0576@2|Bacteria,2G77I@200795|Chloroflexi,375MV@32061|Chloroflexia	32061|Chloroflexia	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
k59_56436_3	1380356.JNIK01000001_gene2236	5.48e-06	48.9	COG1420@1|root,COG1420@2|Bacteria,2GKF5@201174|Actinobacteria,4ERW7@85013|Frankiales	201174|Actinobacteria	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HTH_DeoR,HrcA
k59_1335101_1	768706.Desor_0989	4.44e-49	175.0	COG2804@1|root,COG2804@2|Bacteria,1TPGE@1239|Firmicutes,247KA@186801|Clostridia,2603X@186807|Peptococcaceae	186801|Clostridia	NU	PFAM Type II secretion system protein E	-	-	-	ko:K02454,ko:K02652	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSE,T2SSE_N
k59_945957_2	269797.Mbar_A1823	1.05e-11	68.2	COG0038@1|root,arCOG02569@2157|Archaea,2XW6N@28890|Euryarchaeota,2N9N7@224756|Methanomicrobia	224756|Methanomicrobia	P	Cl- channel, voltage-gated family protein	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,Voltage_CLC
k59_1279542_1	391596.PBAL39_02437	8.12e-06	48.5	COG4181@1|root,COG4181@2|Bacteria,4NEVZ@976|Bacteroidetes,1IP20@117747|Sphingobacteriia	976|Bacteroidetes	Q	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1279542_2	504472.Slin_6498	6.37e-14	74.7	COG3127@1|root,COG3127@2|Bacteria,4NF16@976|Bacteroidetes,47MB7@768503|Cytophagia	976|Bacteroidetes	Q	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_167655_1	883080.HMPREF9697_03533	1.17e-81	255.0	COG1679@1|root,COG1679@2|Bacteria,1NFH4@1224|Proteobacteria,2TTR6@28211|Alphaproteobacteria,3K4FK@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF521)	-	-	-	ko:K09123	-	-	-	-	ko00000	-	-	-	DUF521
k59_1001590_1	760192.Halhy_1977	2.04e-130	386.0	COG2382@1|root,COG2382@2|Bacteria,4NGBK@976|Bacteroidetes,1IY44@117747|Sphingobacteriia	976|Bacteroidetes	P	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
k59_56463_1	350688.Clos_0969	1.26e-30	117.0	COG0057@1|root,COG0057@2|Bacteria,1TNYU@1239|Firmicutes,247IZ@186801|Clostridia,36DD0@31979|Clostridiaceae	186801|Clostridia	G	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gap	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
k59_56463_2	1173027.Mic7113_4370	1.14e-09	59.7	COG0126@1|root,COG0126@2|Bacteria,1G2FM@1117|Cyanobacteria,1H76C@1150|Oscillatoriales	1117|Cyanobacteria	G	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
k59_112054_1	1118054.CAGW01000061_gene2394	0.000379	46.6	COG1595@1|root,COG1595@2|Bacteria,1V9ZH@1239|Firmicutes,4HGNB@91061|Bacilli,26USU@186822|Paenibacillaceae	91061|Bacilli	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_779189_1	1173023.KE650771_gene5472	1.21e-32	121.0	COG0451@1|root,COG0451@2|Bacteria,1G559@1117|Cyanobacteria,1JKQ5@1189|Stigonemataceae	1117|Cyanobacteria	GM	NADP oxidoreductase coenzyme F420-dependent	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
k59_779189_2	221288.JH992900_gene381	5.75e-54	176.0	COG0702@1|root,COG0702@2|Bacteria,1GC7V@1117|Cyanobacteria	1117|Cyanobacteria	GM	NAD(P)H-binding	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10
k59_390033_1	330214.NIDE3191	2.1e-31	125.0	COG3408@1|root,COG3408@2|Bacteria,3J0Z8@40117|Nitrospirae	40117|Nitrospirae	G	Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N_bis
k59_390033_2	640511.BC1002_6364	1.17e-16	79.7	COG0438@1|root,COG0438@2|Bacteria,1MWSZ@1224|Proteobacteria,2VMD3@28216|Betaproteobacteria,1K4RT@119060|Burkholderiaceae	28216|Betaproteobacteria	M	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
k59_612408_1	1123371.ATXH01000008_gene232	4.93e-50	168.0	COG0212@1|root,COG0212@2|Bacteria,2GIAY@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	H	5-formyltetrahydrofolate cyclo-ligase family	-	-	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
k59_1446396_1	439292.Bsel_1354	9.07e-81	252.0	COG0538@1|root,COG0538@2|Bacteria,1UHPE@1239|Firmicutes,4H9US@91061|Bacilli,26NM2@186821|Sporolactobacillaceae	91061|Bacilli	C	Isocitrate/isopropylmalate dehydrogenase	icd	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
k59_612414_1	1082933.MEA186_34099	1.41e-15	80.9	COG0477@1|root,COG2814@2|Bacteria,1MW6T@1224|Proteobacteria,2U1KC@28211|Alphaproteobacteria,43HVX@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	EGP	Uncharacterised MFS-type transporter YbfB	-	-	-	-	-	-	-	-	-	-	-	-	MFS_4
k59_1613098_1	261292.Nit79A3_3381	1.51e-98	319.0	COG0493@1|root,COG0543@1|root,COG0493@2|Bacteria,COG0543@2|Bacteria,1PV5D@1224|Proteobacteria,2WB3J@28216|Betaproteobacteria,37281@32003|Nitrosomonadales	28216|Betaproteobacteria	CEH	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
k59_1112855_2	1336208.JADY01000002_gene253	1.62e-58	193.0	COG3705@1|root,COG3705@2|Bacteria,1MWIG@1224|Proteobacteria,2TSVG@28211|Alphaproteobacteria,2JQ2B@204441|Rhodospirillales	204441|Rhodospirillales	E	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine	hisZ	-	-	ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002	-	-	-	tRNA-synt_His
k59_1501945_1	1210884.HG799465_gene12109	1.49e-60	207.0	COG0714@1|root,COG0714@2|Bacteria,2J4WP@203682|Planctomycetes	203682|Planctomycetes	S	Associated with various cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1670468_1	1379270.AUXF01000005_gene582	1.35e-39	151.0	COG0697@1|root,COG2976@1|root,COG0697@2|Bacteria,COG2976@2|Bacteria,1ZT9A@142182|Gemmatimonadetes	142182|Gemmatimonadetes	EG	Protein of unknown function (DUF2723)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2723
k59_614119_1	1349767.GJA_418	1.16e-14	73.6	COG1462@1|root,COG1462@2|Bacteria,1NDU8@1224|Proteobacteria,2VZST@28216|Betaproteobacteria,478QI@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Curli production assembly/transport component CsgG	-	-	-	-	-	-	-	-	-	-	-	-	CsgG
k59_725488_1	326427.Cagg_1628	3.18e-09	63.5	COG0649@1|root,COG0649@2|Bacteria,2G5JF@200795|Chloroflexi,37504@32061|Chloroflexia	32061|Chloroflexia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD2	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
k59_947775_1	710687.KI912270_gene5742	2.34e-52	177.0	COG5361@1|root,COG5361@2|Bacteria,2GKTA@201174|Actinobacteria,2379R@1762|Mycobacteriaceae	201174|Actinobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_669832_1	331869.BAL199_25059	5.73e-84	265.0	COG5476@1|root,COG5476@2|Bacteria,1MX4P@1224|Proteobacteria,2TS1C@28211|Alphaproteobacteria,4BRRD@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Involved in peptidolytic degradation of cyclic heptapeptide hepatotoxin microcystin (MC)	MA20_32350	-	-	-	-	-	-	-	-	-	-	-	DUF1485,MlrC_C
k59_1225949_1	1121930.AQXG01000017_gene3126	1.02e-57	194.0	COG3547@1|root,COG3547@2|Bacteria	2|Bacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_947781_2	717785.HYPMC_2956	2.78e-21	93.6	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,2TSX9@28211|Alphaproteobacteria,3N6CA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	BQ	histone deacetylase	acuC	-	-	ko:K04768	-	-	-	-	ko00000	-	-	-	Hist_deacetyl
k59_169446_1	552811.Dehly_0344	3.84e-29	108.0	COG0222@1|root,COG0222@2|Bacteria,2G700@200795|Chloroflexi,34DD0@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	-	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
k59_169446_2	1227454.C446_10915	3.62e-06	50.4	COG0589@1|root,arCOG00449@2157|Archaea,2XVAF@28890|Euryarchaeota,23UZU@183963|Halobacteria	183963|Halobacteria	T	COG0589 Universal stress protein UspA and related nucleotide-binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_1336927_2	1347368.HG964403_gene4558	2.61e-06	48.9	COG1522@1|root,COG1522@2|Bacteria,1V319@1239|Firmicutes,4HFNU@91061|Bacilli,1ZD2Z@1386|Bacillus	91061|Bacilli	K	helix_turn_helix ASNC type	bkdR	GO:0001101,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0042221,GO:0043200,GO:0043565,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1901698,GO:1901700,GO:1903506,GO:2000112,GO:2001141	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
k59_1448223_1	1278073.MYSTI_07864	5.57e-28	117.0	COG0577@1|root,COG0577@2|Bacteria,1NREW@1224|Proteobacteria	1224|Proteobacteria	V	COG0577 ABC-type antimicrobial peptide transport system permease component	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_947797_1	443152.MDG893_15387	6.93e-73	240.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,1RQPW@1236|Gammaproteobacteria,469ZW@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	-	-	-	-	-	-	-	-	-	TctA
k59_1058901_1	1121022.ABENE_21950	1.17e-62	203.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TSGZ@28211|Alphaproteobacteria,2KHQT@204458|Caulobacterales	204458|Caulobacterales	L	PFAM transposase IS116 IS110 IS902 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1614804_1	330084.JNYZ01000005_gene906	1.12e-28	117.0	COG0624@1|root,COG0624@2|Bacteria,2GKKW@201174|Actinobacteria	201174|Actinobacteria	E	COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
k59_1114703_1	1057002.KB905370_gene3457	1.38e-61	206.0	COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,2TS6X@28211|Alphaproteobacteria,4B8QI@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Putative transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
k59_1114703_2	398511.BpOF4_16060	6.85e-08	57.0	COG4974@1|root,COG4974@2|Bacteria,1URNQ@1239|Firmicutes,4HEPI@91061|Bacilli,1ZRM1@1386|Bacillus	91061|Bacilli	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
k59_1559276_1	1532557.JL37_08880	1.34e-126	393.0	COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,2VI7M@28216|Betaproteobacteria,3T1UC@506|Alcaligenaceae	28216|Betaproteobacteria	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_1225985_1	1121930.AQXG01000008_gene175	1.52e-62	207.0	COG4826@1|root,COG4826@2|Bacteria,4NG1G@976|Bacteroidetes,1IRRU@117747|Sphingobacteriia	976|Bacteroidetes	O	Belongs to the serpin family	-	-	-	ko:K13963	ko05146,map05146	-	-	-	ko00000,ko00001	-	-	-	Serpin
k59_113836_2	1123511.KB905872_gene1845	4.97e-207	586.0	COG3344@1|root,COG3344@2|Bacteria,1TP9A@1239|Firmicutes,4H53T@909932|Negativicutes	909932|Negativicutes	L	RNA-directed DNA polymerase	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k59_453636_2	1185652.USDA257_c52530	8.72e-15	70.5	COG0257@1|root,COG0257@2|Bacteria,1NGBJ@1224|Proteobacteria,2UJAG@28211|Alphaproteobacteria,4BHII@82115|Rhizobiaceae	28211|Alphaproteobacteria	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	-	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
k59_1009504_2	234267.Acid_6867	3.04e-72	221.0	COG3415@1|root,COG3415@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_29,HTH_32
k59_842303_1	926569.ANT_18700	1.22e-25	106.0	COG0457@1|root,COG0457@2|Bacteria,2G70Z@200795|Chloroflexi	200795|Chloroflexi	O	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r1_1,TPR_16,TPR_19,TPR_8
k59_842303_2	1286171.EAL2_c15600	2.62e-12	68.2	COG0213@1|root,COG0213@2|Bacteria,1TPCH@1239|Firmicutes,24848@186801|Clostridia,25VRI@186806|Eubacteriaceae	186801|Clostridia	F	Pyrimidine nucleoside phosphorylase C-terminal domain	pdp	-	2.4.2.2,2.4.2.4	ko:K00756,ko:K00758	ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219	-	R01570,R01876,R02296,R02484,R08222,R08230	RC00063	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS08925	Glycos_trans_3N,Glycos_transf_3,PYNP_C
k59_731704_1	1120973.AQXL01000109_gene1922	6.43e-62	213.0	COG0046@1|root,COG0046@2|Bacteria,1TPAS@1239|Firmicutes,4HB3N@91061|Bacilli,2783J@186823|Alicyclobacillaceae	91061|Bacilli	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
k59_119535_1	1211114.ALIP01000152_gene2674	7.05e-46	158.0	COG0106@1|root,COG0106@2|Bacteria,1MW6S@1224|Proteobacteria,1RN3M@1236|Gammaproteobacteria,1X3ZJ@135614|Xanthomonadales	135614|Xanthomonadales	E	1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase	hisA	GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
k59_898549_1	349521.HCH_01952	7.21e-80	255.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,1RR36@1236|Gammaproteobacteria	1236|Gammaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	CHASE2,Pkinase
k59_1620610_1	926569.ANT_10540	1.07e-47	163.0	COG0711@1|root,COG0712@1|root,COG0711@2|Bacteria,COG0712@2|Bacteria,2G76T@200795|Chloroflexi	200795|Chloroflexi	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpF	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
k59_620022_1	938289.CAJN020000002_gene663	6.55e-08	55.8	COG0597@1|root,COG0597@2|Bacteria,1VA9R@1239|Firmicutes,24QPP@186801|Clostridia	186801|Clostridia	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
k59_620022_2	1089553.Tph_c12940	4.1e-09	57.8	COG1734@1|root,COG1734@2|Bacteria,1V6MF@1239|Firmicutes,24K3N@186801|Clostridia,42FT9@68295|Thermoanaerobacterales	186801|Clostridia	K	TIGRFAM sporulation protein, yteA	-	-	-	-	-	-	-	-	-	-	-	-	zf-dskA_traR
k59_8892_1	926569.ANT_25170	1.53e-75	240.0	COG0612@1|root,COG0612@2|Bacteria,2G5N3@200795|Chloroflexi	200795|Chloroflexi	S	Peptidase M16 domain protein	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_1232755_1	118173.KB235914_gene2162	1.32e-42	145.0	COG1443@1|root,COG1443@2|Bacteria,1GDFS@1117|Cyanobacteria	1117|Cyanobacteria	I	NUDIX domain	-	-	5.3.3.2	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123	RC00455	ko00000,ko00001,ko00002,ko01000	-	-	-	NUDIX
k59_1232755_2	1097668.BYI23_A006200	1.77e-83	249.0	COG0717@1|root,COG0717@2|Bacteria,1MV2J@1224|Proteobacteria,2VIJ0@28216|Betaproteobacteria,1K38F@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Belongs to the dCTP deaminase family	dcd	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	dUTPase
k59_1620622_1	313628.LNTAR_24818	3.38e-88	273.0	COG3328@1|root,COG3328@2|Bacteria	2|Bacteria	L	transposase activity	tnp	-	-	ko:K07493	-	-	-	-	ko00000	-	-	-	Transposase_mut
k59_1064872_1	331869.BAL199_06314	1.11e-10	67.8	COG1807@1|root,COG1807@2|Bacteria,1QRMT@1224|Proteobacteria,2TU25@28211|Alphaproteobacteria,4BQW6@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008378,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	-	-	-	-	-	-	-	-	-	-	PMT_2
k59_119554_1	1205680.CAKO01000037_gene1315	1.13e-67	217.0	COG2141@1|root,COG2141@2|Bacteria,1MX64@1224|Proteobacteria,2TV8M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_1232760_1	1038862.KB893806_gene3303	1.08e-29	117.0	COG1215@1|root,COG1215@2|Bacteria,1R26S@1224|Proteobacteria,2TZBX@28211|Alphaproteobacteria,3K3FB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_509006_2	861299.J421_4404	1.72e-33	130.0	COG1450@1|root,COG1450@2|Bacteria,1ZT9Y@142182|Gemmatimonadetes	142182|Gemmatimonadetes	NU	Bacterial type II and III secretion system protein	-	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Secretin,Secretin_N
k59_1509738_1	98439.AJLL01000107_gene4294	1.26e-28	118.0	COG0147@1|root,COG0147@2|Bacteria,1G0KZ@1117|Cyanobacteria,1JJ8P@1189|Stigonemataceae	1117|Cyanobacteria	EH	Anthranilate synthase component I, N terminal region	trpE	GO:0000162,GO:0003674,GO:0003824,GO:0004049,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016833,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
k59_620036_1	1379698.RBG1_1C00001G0757	2.24e-10	63.5	COG3832@1|root,COG3832@2|Bacteria	2|Bacteria	J	glyoxalase III activity	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1,Polyketide_cyc2
k59_1342878_1	485913.Krac_4924	2.54e-23	102.0	COG1721@1|root,COG1721@2|Bacteria,2G6Y7@200795|Chloroflexi	200795|Chloroflexi	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
k59_1342886_1	1128421.JAGA01000002_gene906	7.91e-86	279.0	COG0525@1|root,COG0525@2|Bacteria,2NNKR@2323|unclassified Bacteria	2|Bacteria	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
k59_342025_1	1128421.JAGA01000002_gene375	1.55e-09	57.8	COG2003@1|root,COG2003@2|Bacteria,2NPI9@2323|unclassified Bacteria	2|Bacteria	E	Belongs to the UPF0758 family	radC	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
k59_342025_2	927704.SELR_15320	5.37e-11	61.2	COG1254@1|root,COG1254@2|Bacteria,1U4H0@1239|Firmicutes,4H5P8@909932|Negativicutes	909932|Negativicutes	C	Acylphosphatase	acyP	-	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
k59_509024_1	1173028.ANKO01000041_gene3223	5.42e-145	424.0	COG0493@1|root,COG0493@2|Bacteria,1G0SD@1117|Cyanobacteria,1H8CN@1150|Oscillatoriales	1117|Cyanobacteria	E	TIGRFAM glutamate synthases, NADH NADPH, small subunit	gltD	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	iJN678.gltD	Fer4_20,Pyr_redox_2
k59_842359_1	1173024.KI912148_gene3094	6.33e-59	201.0	COG1249@1|root,COG1249@2|Bacteria,1G198@1117|Cyanobacteria,1JKU8@1189|Stigonemataceae	1117|Cyanobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	merA	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim,SNARE_assoc
k59_119593_1	309801.trd_A0514	1.25e-56	196.0	COG0145@1|root,COG0145@2|Bacteria,2G5KZ@200795|Chloroflexi,27XUM@189775|Thermomicrobia	189775|Thermomicrobia	EQ	Hydantoinaseoxoprolinase domain protein	-	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
k59_397833_1	379066.GAU_3347	4.63e-59	192.0	COG2362@1|root,COG2362@2|Bacteria	2|Bacteria	E	D-aminopeptidase	dppA	-	-	ko:K16203	-	-	-	-	ko00000,ko01000,ko01002	3.A.1.5.2	-	-	Peptidase_M55
k59_1398592_1	204669.Acid345_3471	9.81e-16	79.7	COG0577@1|root,COG0577@2|Bacteria,3Y41Z@57723|Acidobacteria,2JI5N@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_1620669_2	1499967.BAYZ01000045_gene2655	2.78e-16	77.8	COG0484@1|root,COG0484@2|Bacteria	2|Bacteria	O	heat shock protein binding	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
k59_1565360_2	207559.Dde_1506	5.7e-78	236.0	COG2236@1|root,COG2236@2|Bacteria,1MWNE@1224|Proteobacteria,42RSU@68525|delta/epsilon subdivisions,2WMYZ@28221|Deltaproteobacteria,2MB60@213115|Desulfovibrionales	28221|Deltaproteobacteria	F	Acts on guanine, xanthine and to a lesser extent hypoxanthine	gpt	-	2.4.2.22	ko:K00769	ko00230,ko01100,ko01110,map00230,map01100,map01110	-	R01229,R02142	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
k59_64282_1	1382356.JQMP01000003_gene1325	3.25e-142	419.0	COG1012@1|root,COG1012@2|Bacteria,2G5JZ@200795|Chloroflexi,27Y57@189775|Thermomicrobia	189775|Thermomicrobia	C	Belongs to the aldehyde dehydrogenase family	-	-	-	ko:K22187	ko00040,map00040	-	R11768	RC00080	ko00000,ko00001,ko01000	-	-	-	Aldedh
k59_1342912_1	404589.Anae109_0814	1.25e-31	118.0	COG0847@1|root,COG0847@2|Bacteria,1RAF1@1224|Proteobacteria,43AQH@68525|delta/epsilon subdivisions,2X64E@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM Exonuclease, RNase T and DNA polymerase III	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
k59_1342912_2	526227.Mesil_1584	1.07e-35	135.0	COG2905@1|root,COG2905@2|Bacteria,1WIBT@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	signal-transduction protein containing cAMP-binding and CBS domains	-	-	-	ko:K07182	-	-	-	-	ko00000	-	-	-	CBS,DUF294,DUF294_C,cNMP_binding
k59_342054_1	420662.Mpe_A0078	0.000553	43.5	COG1752@1|root,COG1752@2|Bacteria,1MVHW@1224|Proteobacteria,2VH3I@28216|Betaproteobacteria,1KJ59@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
k59_898646_1	1122132.AQYH01000010_gene3974	1.06e-94	296.0	COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,2TT32@28211|Alphaproteobacteria,4B8BF@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009380,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0071496,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
k59_397851_1	675813.VIB_001591	0.000264	43.5	COG0697@1|root,COG0697@2|Bacteria,1MZQM@1224|Proteobacteria,1SZQ8@1236|Gammaproteobacteria,1Y2WQ@135623|Vibrionales	135623|Vibrionales	EG	of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_397851_2	195105.CN97_16315	5.46e-21	92.4	COG3173@1|root,COG3173@2|Bacteria,1MWAK@1224|Proteobacteria,2TT2N@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Aminoglycoside phosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	APH
k59_1342937_1	1185876.BN8_03383	2.7e-40	152.0	COG4447@1|root,COG4447@2|Bacteria,4NESU@976|Bacteroidetes,47NMF@768503|Cytophagia	976|Bacteroidetes	G	Sortilin, neurotensin receptor 3,	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
k59_231350_1	373903.Hore_04850	2.16e-83	269.0	COG2217@1|root,COG2217@2|Bacteria,1TP5S@1239|Firmicutes,247MW@186801|Clostridia,3WB5V@53433|Halanaerobiales	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	copA	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
k59_64318_1	234267.Acid_7338	2.51e-10	65.1	COG1228@1|root,COG1228@2|Bacteria,3Y39J@57723|Acidobacteria	57723|Acidobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_566167_1	575540.Isop_0659	2.03e-32	128.0	COG1287@1|root,COG1287@2|Bacteria,2J0B8@203682|Planctomycetes	203682|Planctomycetes	S	oligosaccharyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1011489_1	1125971.ASJB01000097_gene567	4.72e-48	167.0	COG3214@1|root,COG3214@2|Bacteria,2GK0T@201174|Actinobacteria,4DZPY@85010|Pseudonocardiales	201174|Actinobacteria	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
k59_399687_1	661367.LLO_0442	7.46e-05	46.6	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,1RPB4@1236|Gammaproteobacteria,1JCBM@118969|Legionellales	118969|Legionellales	V	ABC transporter, permease	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
k59_399687_2	706587.Desti_5235	6.38e-58	191.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42MV1@68525|delta/epsilon subdivisions,2WK9W@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	PFAM ABC transporter	ybhF-C	-	-	ko:K01990,ko:K09695	ko02010,map02010	M00252,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.102	-	-	ABC_tran,DUF4162
k59_10661_2	545693.BMQ_2501	2.53e-07	54.7	COG0431@1|root,COG0431@2|Bacteria,1V3WV@1239|Firmicutes,4HHT9@91061|Bacilli,1ZGEI@1386|Bacillus	91061|Bacilli	S	NADPH-dependent FMN reductase	azr	-	1.7.1.6	ko:K03206	-	-	-	-	ko00000,ko01000	-	-	-	FMN_red
k59_233088_1	195250.CM001776_gene605	5.99e-56	196.0	COG0068@1|root,COG0068@2|Bacteria,1G063@1117|Cyanobacteria,1GZUM@1129|Synechococcus	1117|Cyanobacteria	O	Belongs to the carbamoyltransferase HypF family	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
k59_900537_1	379066.GAU_1285	6.74e-108	331.0	COG0441@1|root,COG0441@2|Bacteria,1ZT2I@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
k59_1511599_2	926569.ANT_28990	2.79e-38	138.0	COG0448@1|root,COG0448@2|Bacteria,2G66Q@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
k59_789081_2	556269.ACDQ01000009_gene2002	0.000985	40.0	COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,2VSVW@28216|Betaproteobacteria,478RR@75682|Oxalobacteraceae	28216|Betaproteobacteria	U	Biopolymer transport protein ExbD/TolR	exbD1	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
k59_1622316_1	1150864.MILUP08_41479	0.000923	47.0	COG0142@1|root,COG0644@1|root,COG0142@2|Bacteria,COG0644@2|Bacteria,2GKGH@201174|Actinobacteria,4DAZF@85008|Micromonosporales	201174|Actinobacteria	C	geranylgeranyl reductase	-	-	1.3.99.38	ko:K21401	-	-	-	-	ko00000,ko01000	-	-	-	FAD_binding_3
k59_1234788_1	1121124.JNIX01000011_gene1656	2.83e-104	323.0	COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,2TRUM@28211|Alphaproteobacteria,2KI6R@204458|Caulobacterales	204458|Caulobacterales	E	leukotriene A-4 hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Leuk-A4-hydro_C,Peptidase_M1
k59_1122983_1	1121106.JQKB01000010_gene512	1.27e-25	108.0	COG0477@1|root,COG2814@2|Bacteria,1P3S4@1224|Proteobacteria,2TVAQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
k59_789092_1	562970.Btus_2140	1.44e-13	70.1	COG0696@1|root,COG0696@2|Bacteria,1TPM4@1239|Firmicutes,4HBTQ@91061|Bacilli,2784V@186823|Alicyclobacillaceae	91061|Bacilli	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmI	GO:0003674,GO:0003824,GO:0004619,GO:0005488,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0030145,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043167,GO:0043169,GO:0043436,GO:0043937,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046537,GO:0046700,GO:0046872,GO:0046914,GO:0046939,GO:0050789,GO:0050793,GO:0051186,GO:0051188,GO:0055086,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,Phosphodiest,iPGM_N
k59_789092_2	709986.Deima_2651	4.55e-19	87.0	COG0237@1|root,COG0237@2|Bacteria,1WK2X@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	F	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE
k59_1567275_1	501479.ACNW01000076_gene1755	3.32e-10	65.1	COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,2TV4H@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	macA	-	-	ko:K02005,ko:K13888	-	M00709	-	-	ko00000,ko00002,ko02000	8.A.1	-	-	HlyD_D23
k59_678009_1	981369.JQMJ01000004_gene1283	2.24e-12	72.0	COG0515@1|root,COG0515@2|Bacteria,2GJ1J@201174|Actinobacteria,2NGUG@228398|Streptacidiphilus	201174|Actinobacteria	KLT	PASTA domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
k59_1678276_1	1192124.LIG30_4279	1.85e-103	310.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,2VI6I@28216|Betaproteobacteria,1K0WZ@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	-	-	-	ko:K00646	-	-	-	-	ko00000,ko01008	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_1234821_1	459495.SPLC1_S541300	6.68e-20	90.5	COG4221@1|root,COG4221@2|Bacteria,1G1CB@1117|Cyanobacteria,1H8AJ@1150|Oscillatoriales	1117|Cyanobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_844099_1	335543.Sfum_0701	5.27e-106	312.0	COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,42MWA@68525|delta/epsilon subdivisions,2WJEX@28221|Deltaproteobacteria,2MR99@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
k59_1344630_1	324602.Caur_1924	1.43e-131	384.0	COG4213@1|root,COG4213@2|Bacteria,2G6C4@200795|Chloroflexi,377C5@32061|Chloroflexia	32061|Chloroflexia	G	Periplasmic binding protein domain	-	-	-	ko:K10546	ko02010,map02010	M00216	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.5	-	-	Peripla_BP_4
k59_1178098_1	215803.DB30_1619	3.86e-47	168.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
k59_1400400_1	926550.CLDAP_02330	6.12e-70	229.0	COG0173@1|root,COG0173@2|Bacteria,2G5RX@200795|Chloroflexi	200795|Chloroflexi	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
k59_1456413_1	1033802.SSPSH_002382	1.05e-43	160.0	COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
k59_1123031_1	1116472.MGMO_20c00060	1.46e-51	166.0	2D8VC@1|root,32TS1@2|Bacteria,1MZWT@1224|Proteobacteria,1T747@1236|Gammaproteobacteria,1XGP9@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1123031_2	439497.RR11_3408	2.74e-07	51.2	COG1309@1|root,COG1309@2|Bacteria,1QIJW@1224|Proteobacteria,2TWD8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	transcriptional regulator	-	-	-	ko:K16137	-	-	-	-	ko00000,ko03000	-	-	-	TetR_C_13,TetR_N
k59_1567314_1	926569.ANT_27790	2.49e-67	213.0	COG0375@1|root,COG0500@1|root,COG0375@2|Bacteria,COG2226@2|Bacteria,2G8EN@200795|Chloroflexi	200795|Chloroflexi	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_848732_1	349102.Rsph17025_2189	7.31e-79	252.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,2TS07@28211|Alphaproteobacteria,1FAT3@1060|Rhodobacter	28211|Alphaproteobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
k59_738484_1	1122132.AQYH01000008_gene2356	4.71e-129	375.0	COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,2TRUG@28211|Alphaproteobacteria,4B84D@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
k59_738484_2	348824.LPU83_2736	9.36e-13	67.8	COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,2TTE8@28211|Alphaproteobacteria,4B6ZF@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
k59_181831_1	1283300.ATXB01000001_gene79	1.91e-23	97.8	COG4967@1|root,COG4967@2|Bacteria,1N6TG@1224|Proteobacteria,1SC9Z@1236|Gammaproteobacteria,1XFI4@135618|Methylococcales	135618|Methylococcales	NU	TIGRFAM Pilus modification type IV, PilV	-	-	-	ko:K02671	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	N_methyl
k59_70880_1	479431.Namu_2557	0.000504	42.0	COG1765@1|root,COG1765@2|Bacteria,2IFY4@201174|Actinobacteria,4ET1W@85013|Frankiales	201174|Actinobacteria	O	PFAM OsmC family protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
k59_70880_2	714943.Mucpa_1075	1.87e-36	134.0	COG3266@1|root,COG3266@2|Bacteria,4NFRK@976|Bacteroidetes,1IPA7@117747|Sphingobacteriia	976|Bacteroidetes	S	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_960533_1	926569.ANT_11790	4.38e-35	130.0	COG1192@1|root,COG1192@2|Bacteria,2G62U@200795|Chloroflexi	200795|Chloroflexi	D	PFAM Cobyrinic acid a,c-diamide synthase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_31
k59_1016545_1	1550073.JROH01000035_gene2610	1.71e-72	231.0	COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,2TQT3@28211|Alphaproteobacteria,2K0CT@204457|Sphingomonadales	204457|Sphingomonadales	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Radical_SAM
k59_238086_1	395961.Cyan7425_4616	7.15e-05	51.2	COG0642@1|root,COG0745@1|root,COG0784@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG2205@2|Bacteria,1G09B@1117|Cyanobacteria,3KH7X@43988|Cyanothece	1117|Cyanobacteria	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
k59_1516440_1	580332.Slit_0536	6.9e-25	103.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,44VNC@713636|Nitrosomonadales	28216|Betaproteobacteria	NU	General secretory system II protein E domain protein	-	-	-	ko:K02454,ko:K02652,ko:K12276	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	GAF,T2SSE,T2SSE_N
k59_1516440_2	640081.Dsui_1456	6.46e-52	180.0	COG2203@1|root,COG2206@1|root,COG2203@2|Bacteria,COG2206@2|Bacteria,1MV37@1224|Proteobacteria,2VJ21@28216|Betaproteobacteria,2KVJ8@206389|Rhodocyclales	206389|Rhodocyclales	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	3.1.4.17	ko:K01120	ko00230,map00230	-	R00191,R01234	RC00296	ko00000,ko00001,ko01000	-	-	-	FHA,GAF,HD,HD_5
k59_460901_1	460265.Mnod_2242	7.02e-57	192.0	COG0477@1|root,COG2814@2|Bacteria,1MX4G@1224|Proteobacteria,2TTT7@28211|Alphaproteobacteria,1JUCD@119045|Methylobacteriaceae	28211|Alphaproteobacteria	EGP	COG0477 Permeases of the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_626512_1	224324.aq_1971	3.59e-08	60.1	COG2804@1|root,COG2804@2|Bacteria,2G3UR@200783|Aquificae	200783|Aquificae	NU	PFAM Type II secretion system protein E	-	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
k59_293600_1	595536.ADVE02000001_gene2492	5.53e-75	236.0	COG4034@1|root,COG4034@2|Bacteria,1RCEU@1224|Proteobacteria,2UPTR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1152)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1152
k59_1627104_1	1192034.CAP_3887	4.59e-50	176.0	COG0654@1|root,COG1902@1|root,COG0654@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,42PDA@68525|delta/epsilon subdivisions,2WK05@28221|Deltaproteobacteria,2YZMG@29|Myxococcales	28221|Deltaproteobacteria	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	1.14.13.40	ko:K09461	ko00627,ko01120,map00627,map01120	-	R03998,R03999	RC00244	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3,Oxidored_FMN
k59_1293881_1	715226.ABI_44870	1.71e-105	325.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VFYM@28211|Alphaproteobacteria,2KK14@204458|Caulobacterales	204458|Caulobacterales	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_960577_1	37919.EP51_46845	6.78e-12	65.5	COG1028@1|root,COG1028@2|Bacteria,2I8MC@201174|Actinobacteria,4FZS2@85025|Nocardiaceae	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	hcaB	-	1.3.1.87	ko:K05711	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06784,R06785	RC00534	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	adh_short
k59_960577_2	156978.CIMIT_11745	8.29e-29	110.0	COG5517@1|root,COG5517@2|Bacteria,2ITEX@201174|Actinobacteria,22N1X@1653|Corynebacteriaceae	201174|Actinobacteria	Q	Ring hydroxylating beta subunit	-	-	-	-	-	-	-	-	-	-	-	-	Ring_hydroxyl_B
k59_126050_1	716928.AJQT01000058_gene5391	1.83e-32	118.0	COG2335@1|root,COG2335@2|Bacteria,1RD06@1224|Proteobacteria,2U7H5@28211|Alphaproteobacteria,4BFQ4@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	Four repeated domains in the Fasciclin I family of proteins, present in many other contexts.	-	-	-	-	-	-	-	-	-	-	-	-	Fasciclin
k59_126050_3	452637.Oter_2665	3.52e-06	48.1	COG0415@1|root,COG0415@2|Bacteria,46TVC@74201|Verrucomicrobia,3K926@414999|Opitutae	414999|Opitutae	H	PFAM DNA photolyase FAD-binding	-	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
k59_238124_1	396588.Tgr7_3266	3.01e-12	65.5	COG4967@1|root,COG4967@2|Bacteria	2|Bacteria	NU	type IV pilus modification protein PilV	mshD	-	-	ko:K10927	ko05111,map05111	-	-	-	ko00000,ko00001,ko02044	-	-	-	N_methyl
k59_905628_1	1459636.NTE_03516	2.48e-63	205.0	COG0330@1|root,arCOG01915@2157|Archaea	2157|Archaea	O	COG0330 Membrane protease subunits stomatin prohibitin homologs	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
k59_626529_2	1033740.CAEW01000040_gene202	7.73e-17	82.0	COG1281@1|root,COG1281@2|Bacteria,1TRCH@1239|Firmicutes,4HAFR@91061|Bacilli,26DJU@186818|Planococcaceae	91061|Bacilli	O	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress	hslO	-	-	ko:K04083	-	-	-	-	ko00000,ko03110	-	-	-	HSP33
k59_15701_1	1319815.HMPREF0202_00571	9.92e-54	184.0	COG4865@1|root,COG4865@2|Bacteria,3798R@32066|Fusobacteria	32066|Fusobacteria	E	Catalyzes the carbon skeleton rearrangement of L- glutamate to L-threo-3-methylaspartate ((2S,3S)-3- methylaspartate)	glmE	-	5.4.99.1	ko:K19268	ko00630,ko00660,ko01100,ko01200,map00630,map00660,map01100,map01200	M00740	R00262	RC01221	ko00000,ko00001,ko00002,ko01000	-	-	-	Met_asp_mut_E
k59_1738815_1	1163408.UU9_10597	4.42e-68	223.0	COG1874@1|root,COG1874@2|Bacteria,1P0Y5@1224|Proteobacteria,1RZHZ@1236|Gammaproteobacteria,1X4DM@135614|Xanthomonadales	1236|Gammaproteobacteria	G	glycoside hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_571028_1	1121422.AUMW01000036_gene2696	1.18e-16	84.3	COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,26166@186807|Peptococcaceae	186801|Clostridia	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Fer4_7,Pyr_redox_2
k59_515990_1	240016.ABIZ01000001_gene3597	1.62e-37	142.0	COG1861@1|root,COG1861@2|Bacteria,46UVT@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Transposase DDE domain group 1	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k59_1071706_2	1408473.JHXO01000003_gene2559	1.3e-36	132.0	COG0265@1|root,COG0265@2|Bacteria,4NWGZ@976|Bacteroidetes	976|Bacteroidetes	O	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin,Trypsin_2
k59_960611_1	1267211.KI669560_gene1746	1.71e-26	112.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,4NGU2@976|Bacteroidetes	976|Bacteroidetes	M	Tricorn protease homolog	-	-	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
k59_293646_1	1232410.KI421426_gene1373	7.48e-57	195.0	COG1387@1|root,COG1387@2|Bacteria,1MYXV@1224|Proteobacteria,42MQX@68525|delta/epsilon subdivisions,2WKUP@28221|Deltaproteobacteria,43U78@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	DNA polymerase X family	-	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP
k59_738606_1	1313172.YM304_12570	2.63e-38	140.0	2CDEB@1|root,2ZRID@2|Bacteria,2HDK8@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1349669_1	1305735.JAFT01000005_gene2374	3.67e-27	115.0	COG0210@1|root,COG0514@1|root,COG0210@2|Bacteria,COG0514@2|Bacteria,1MVGG@1224|Proteobacteria,2U11Y@28211|Alphaproteobacteria,2PF9Y@252301|Oceanicola	28211|Alphaproteobacteria	L	DEAD-like helicases superfamily	-	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_19,DEAD,Helicase_C,UvrD_C
k59_516018_1	1379270.AUXF01000003_gene3817	3.88e-14	72.4	COG0565@1|root,COG0565@2|Bacteria,1ZT19@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	SpoU rRNA Methylase family	-	-	2.1.1.200	ko:K02533,ko:K15396	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
k59_71002_1	1442599.JAAN01000045_gene2797	6.81e-67	230.0	COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,1RSEQ@1236|Gammaproteobacteria,1X3DR@135614|Xanthomonadales	135614|Xanthomonadales	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA	-	1.2.7.8	ko:K04090	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR,TPP_enzyme_C
k59_1405558_1	926569.ANT_14430	2.05e-84	258.0	COG0391@1|root,COG0391@2|Bacteria,2G5S2@200795|Chloroflexi	200795|Chloroflexi	S	TIGRFAM LPPG domain protein containing protein	cofD	-	2.7.8.28	ko:K11212	ko00680,ko01120,map00680,map01120	M00378	R09398	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	UPF0052
k59_293662_1	96561.Dole_0153	6.62e-19	90.9	28M0D@1|root,2ZAFE@2|Bacteria,1R6YH@1224|Proteobacteria,42NPF@68525|delta/epsilon subdivisions,2WM7K@28221|Deltaproteobacteria,2MIG7@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Putative ATP-binding cassette	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran_2
k59_1293953_1	926569.ANT_02270	5.84e-79	253.0	COG0195@1|root,COG0195@2|Bacteria,2G5M5@200795|Chloroflexi	200795|Chloroflexi	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_5,NusA_N,S1
k59_71008_1	1174504.AJTN02000041_gene2442	5.69e-44	149.0	COG1327@1|root,COG1327@2|Bacteria,1V3JA@1239|Firmicutes,4HGXA@91061|Bacilli,1ZFS0@1386|Bacillus	91061|Bacilli	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
k59_960668_2	278963.ATWD01000003_gene138	3.34e-63	213.0	COG3039@1|root,COG3039@2|Bacteria,3Y8N9@57723|Acidobacteria,2JNID@204432|Acidobacteriia	204432|Acidobacteriia	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_181987_1	118005.AWNK01000006_gene1357	4.89e-48	165.0	COG1024@1|root,COG1024@2|Bacteria	2|Bacteria	I	Enoyl-CoA hydratase	crt	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_1716	ECH_1
k59_1016683_1	1123065.ATWL01000005_gene1251	1.48e-12	73.9	COG1403@1|root,COG1403@2|Bacteria,2HAHI@201174|Actinobacteria	201174|Actinobacteria	V	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
k59_1351862_1	65093.PCC7418_1447	3.69e-30	118.0	COG3957@1|root,COG3957@2|Bacteria,1G0B2@1117|Cyanobacteria	1117|Cyanobacteria	G	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase	-	-	4.1.2.22,4.1.2.9	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120	-	R00761,R01621	RC00032,RC00226	ko00000,ko00001,ko01000	-	-	-	XFP,XFP_C,XFP_N
k59_1351862_2	323261.Noc_1775	5.52e-28	114.0	COG0637@1|root,COG1554@1|root,COG1877@1|root,COG0637@2|Bacteria,COG1554@2|Bacteria,COG1877@2|Bacteria,1MWJE@1224|Proteobacteria,1RPN6@1236|Gammaproteobacteria,1X03I@135613|Chromatiales	135613|Chromatiales	G	Glycosyl hydrolase family 65 central catalytic domain	-	-	3.2.1.28	ko:K01194	ko00500,ko01100,map00500,map01100	-	R00010	RC00049	ko00000,ko00001,ko00537,ko01000	-	GH37	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m,HAD_2,Trehalose_PPase
k59_1407628_1	264732.Moth_0067	1.06e-36	135.0	COG2998@1|root,COG2998@2|Bacteria,1TQA9@1239|Firmicutes,249EZ@186801|Clostridia,42EUS@68295|Thermoanaerobacterales	186801|Clostridia	H	extracellular solute-binding protein, family 1	tupA	-	-	ko:K05772	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	PBP_like_2
k59_350618_1	1459636.NTE_01784	3.07e-88	273.0	COG0147@1|root,arCOG02014@2157|Archaea,41S8W@651137|Thaumarchaeota	651137|Thaumarchaeota	E	component I	-	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
k59_1296099_1	1121405.dsmv_1099	3.93e-108	320.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,42N06@68525|delta/epsilon subdivisions,2WK5N@28221|Deltaproteobacteria,2MMZ0@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Transketolase, pyrimidine binding domain	bkdB	-	1.2.4.1,1.2.4.4	ko:K00162,ko:K00167	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
k59_1629163_1	529818.AMSG_12051T0	2.46e-72	248.0	COG4799@1|root,KOG0540@2759|Eukaryota	2759|Eukaryota	I	CoA carboxylase activity	-	-	2.1.3.15,6.4.1.3,6.4.1.4	ko:K01966,ko:K01969	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00036,M00373,M00741	R01859,R04138	RC00097,RC00367,RC00609,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_350620_1	290397.Adeh_1074	8.3e-27	114.0	COG0515@1|root,COG2214@1|root,COG0515@2|Bacteria,COG2214@2|Bacteria,1MV1P@1224|Proteobacteria,42NY2@68525|delta/epsilon subdivisions,2WJKQ@28221|Deltaproteobacteria,2YXDF@29|Myxococcales	28221|Deltaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	DUF1566,Pkinase
k59_1407636_1	1397528.Q671_08630	4.3e-81	255.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,1RQP7@1236|Gammaproteobacteria,1XNSE@135619|Oceanospirillales	135619|Oceanospirillales	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_295707_1	1294143.H681_04485	2.13e-101	304.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,1RMAQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_962946_1	1408422.JHYF01000004_gene1636	1.59e-75	238.0	COG0436@1|root,COG0436@2|Bacteria,1TQP0@1239|Firmicutes,2488K@186801|Clostridia,36FI4@31979|Clostridiaceae	186801|Clostridia	E	PFAM aminotransferase, class I	-	-	-	ko:K10907	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_1242237_1	215803.DB30_4033	2.3e-47	172.0	COG1629@1|root,COG4771@2|Bacteria,1QX6X@1224|Proteobacteria,43BZN@68525|delta/epsilon subdivisions,2X7AF@28221|Deltaproteobacteria,2Z3EM@29|Myxococcales	28221|Deltaproteobacteria	M	CarboxypepD_reg-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Plug
k59_1574237_1	1185876.BN8_01931	5.17e-45	162.0	COG1167@1|root,COG1167@2|Bacteria,4NG85@976|Bacteroidetes,47KRC@768503|Cytophagia	976|Bacteroidetes	K	Transcriptional regulator, GntR family with aminotransferase domain	-	-	-	ko:K00375	-	-	-	-	ko00000,ko03000	-	-	-	Aminotran_1_2,GntR
k59_628594_1	29760.VIT_04s0008g03920.t01	9.45e-33	128.0	COG2072@1|root,KOG1399@2759|Eukaryota,37PDP@33090|Viridiplantae,3G7F7@35493|Streptophyta	35493|Streptophyta	Q	monooxygenase	YUC6	-	1.14.13.168	ko:K11816	ko00380,ko01100,map00380,map01100	-	R10181	RC00866	ko00000,ko00001,ko01000	-	-	-	FMO-like,K_oxygenase,Pyr_redox_3
k59_1351898_1	991905.SL003B_0118	1.15e-111	329.0	COG1250@1|root,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2TR8E@28211|Alphaproteobacteria,4BPPQ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	I	3-hydroxyacyl-CoA dehydrogenase	hbdA	-	1.1.1.157,1.1.1.35	ko:K00074,ko:K07516	ko00071,ko00360,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00360,map00362,map00650,map01100,map01120,map01200,map01212	M00087	R01975,R01976,R04737,R04739,R04741,R04743,R04745,R04748,R05305,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N
k59_628601_1	1160137.KB907308_gene6991	2.99e-26	107.0	COG2084@1|root,COG2084@2|Bacteria,2GTGE@201174|Actinobacteria,4G4IQ@85025|Nocardiaceae	201174|Actinobacteria	I	Domain of unknown function (DUF1932)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1932,F420_oxidored,NAD_binding_2
k59_1185127_1	1027273.GZ77_25605	2.01e-63	201.0	COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,1RPJM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	ATP-binding protein, IstB SW ISTB_ECOLI (P15026) (265 aa) fasta scores E() 0, 47.4 id in 249 aa. Also almost identical to Yersinia pestis and Escherichia coli	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
k59_1242258_1	1317118.ATO8_02780	6.63e-36	138.0	COG4665@1|root,COG4665@2|Bacteria,1QZG7@1224|Proteobacteria,2U0WE@28211|Alphaproteobacteria,4KNCJ@93682|Roseivivax	28211|Alphaproteobacteria	Q	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
k59_128069_1	319225.Plut_1979	7.03e-07	55.8	COG0744@1|root,COG0744@2|Bacteria,1FDQX@1090|Chlorobi	1090|Chlorobi	M	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors	mtgA	-	2.4.1.129	ko:K03814	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly
k59_295744_1	1090319.KE386571_gene1667	1.68e-78	258.0	COG3533@1|root,COG3533@2|Bacteria,1MWEN@1224|Proteobacteria,2U1Q4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	protein conserved in bacteria	-	-	-	ko:K09955	-	-	-	-	ko00000	-	-	-	Glyco_hydro_127
k59_796297_1	511680.BUTYVIB_00540	5.39e-06	53.5	COG0744@1|root,COG0744@2|Bacteria,1TPM5@1239|Firmicutes,248A4@186801|Clostridia	186801|Clostridia	M	penicillin-binding protein 1A	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
k59_740741_1	797209.ZOD2009_09173	9.11e-60	198.0	COG1253@1|root,arCOG00626@2157|Archaea,2XTIW@28890|Euryarchaeota,23SFB@183963|Halobacteria	183963|Halobacteria	S	COG1253 Hemolysins and related proteins containing CBS domains	-	-	-	-	-	-	-	-	-	-	-	-	CBS,DUF21
k59_1463353_1	478749.BRYFOR_07984	4.75e-13	73.9	COG0525@1|root,COG0525@2|Bacteria,1TPN4@1239|Firmicutes,248VC@186801|Clostridia	186801|Clostridia	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
k59_1740964_2	398512.JQKC01000009_gene523	2.64e-08	55.8	COG0750@1|root,COG0750@2|Bacteria,1TPMC@1239|Firmicutes,247MT@186801|Clostridia,3WGQW@541000|Ruminococcaceae	186801|Clostridia	M	Metalloprotease	rseP	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
k59_908043_2	1077285.AGDG01000008_gene2601	3.19e-11	67.8	COG0745@1|root,COG3292@1|root,COG5002@1|root,COG0745@2|Bacteria,COG3292@2|Bacteria,COG5002@2|Bacteria,4P0IA@976|Bacteroidetes,2FWSR@200643|Bacteroidia,4AV24@815|Bacteroidaceae	976|Bacteroidetes	T	ATPase histidine kinase DNA gyrase B HSP90 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y
k59_1740977_1	396014.BF93_16370	1.42e-09	63.9	COG1595@1|root,COG1595@2|Bacteria,2GJMX@201174|Actinobacteria,4FDTM@85020|Dermabacteraceae	201174|Actinobacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_1076257_2	1232683.ADIMK_3343	7.7e-37	128.0	COG2346@1|root,COG2346@2|Bacteria	2|Bacteria	O	COG2346, Truncated hemoglobins	glbN	GO:0001505,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008941,GO:0009056,GO:0009605,GO:0009607,GO:0009636,GO:0009987,GO:0016491,GO:0016705,GO:0016708,GO:0017144,GO:0019825,GO:0020012,GO:0020037,GO:0030682,GO:0034641,GO:0036094,GO:0042133,GO:0042135,GO:0042221,GO:0042737,GO:0043207,GO:0044237,GO:0044248,GO:0044270,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046209,GO:0046210,GO:0046906,GO:0048037,GO:0050896,GO:0051213,GO:0051410,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0052060,GO:0052173,GO:0052200,GO:0052376,GO:0052551,GO:0052564,GO:0052565,GO:0052572,GO:0055114,GO:0065007,GO:0065008,GO:0072593,GO:0075136,GO:0097159,GO:0098754,GO:1901363,GO:1901698,GO:2001057	-	ko:K03406,ko:K06886	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	Bac_globin
k59_1576663_1	1454004.AW11_00534	1.18e-104	315.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,2VH09@28216|Betaproteobacteria	28216|Betaproteobacteria	H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis	ubiD	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
k59_1298707_1	630626.EBL_c39170	2.14e-28	114.0	COG1561@1|root,COG1561@2|Bacteria,1MWRA@1224|Proteobacteria,1RMAB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Stress-induced protein	yicC	GO:0000175,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009022,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:0140101,GO:1901360,GO:1901361,GO:1901575	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
k59_910630_1	1041159.AZUW01000008_gene4443	3.82e-16	84.7	COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,4B81Q@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Adenylate	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DZR,Guanylate_cyc,SAM_1
k59_1687987_1	1410625.JHWK01000002_gene163	1.04e-06	57.0	COG0747@1|root,COG0747@2|Bacteria,1TQ6S@1239|Firmicutes,248A3@186801|Clostridia,27JWV@186928|unclassified Lachnospiraceae	186801|Clostridia	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_1298711_1	1458275.AZ34_13670	6.82e-28	114.0	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2WGYZ@28216|Betaproteobacteria,4AK44@80864|Comamonadaceae	28216|Betaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,SBP_bac_3
k59_1465699_1	391624.OIHEL45_06995	4.63e-119	346.0	COG0600@1|root,COG0600@2|Bacteria,1MVAE@1224|Proteobacteria,2U2CY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	COG0600 ABC-type nitrate sulfonate bicarbonate transport system permease component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
k59_743068_2	1123313.ATUT01000008_gene1762	3.48e-08	56.2	COG2893@1|root,COG2893@2|Bacteria,1VBC1@1239|Firmicutes,3VR5C@526524|Erysipelotrichia	526524|Erysipelotrichia	G	PTS system fructose IIA component	-	-	-	-	-	-	-	-	-	-	-	-	EIIA-man
k59_743068_3	59374.Fisuc_1237	7.33e-07	51.2	COG1493@1|root,COG1493@2|Bacteria	2|Bacteria	T	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion	hprK	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K06023	-	-	-	-	ko00000,ko01000	-	-	-	Hpr_kinase_C,Hpr_kinase_N
k59_1354498_1	1123229.AUBC01000025_gene4486	6.78e-23	96.7	COG1670@1|root,COG1670@2|Bacteria,1N6Q1@1224|Proteobacteria,2UG72@28211|Alphaproteobacteria,3JRYG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	Acetyltransferase (GNAT) domain	MA20_44020	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
k59_1354498_2	563040.Saut_0764	1.12e-18	79.0	COG0211@1|root,COG0211@2|Bacteria,1MZGH@1224|Proteobacteria,42THK@68525|delta/epsilon subdivisions,2YQ0A@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	-	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
k59_1244876_2	543728.Vapar_5502	1.16e-28	115.0	COG2141@1|root,COG2141@2|Bacteria,1MX64@1224|Proteobacteria,2VND1@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_575527_1	1384484.AEQU_0927	2.18e-21	98.2	COG0111@1|root,COG4747@1|root,COG0111@2|Bacteria,COG4747@2|Bacteria,2GJGA@201174|Actinobacteria,4CYP9@84998|Coriobacteriia	84998|Coriobacteriia	E	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_1354521_1	1070774.J07HN4v3_01661	9.23e-32	124.0	COG0438@1|root,arCOG01407@2157|Archaea,2Y8BB@28890|Euryarchaeota,24180@183963|Halobacteria	183963|Halobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
k59_1187556_1	204669.Acid345_2967	4.29e-89	265.0	COG1418@1|root,COG1418@2|Bacteria	2|Bacteria	S	mRNA catabolic process	-	-	-	ko:K06950,ko:K09163	-	-	-	-	ko00000	-	-	-	HD
k59_1631511_1	472759.Nhal_1977	7.18e-15	79.7	COG0642@1|root,COG0745@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1T216@1236|Gammaproteobacteria,1X2RD@135613|Chromatiales	135613|Chromatiales	T	PFAM ATP-binding region, ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
k59_1410126_1	429009.Adeg_0164	6.81e-37	142.0	COG4231@1|root,COG4231@2|Bacteria,1TNY3@1239|Firmicutes,247U1@186801|Clostridia,42EZ8@68295|Thermoanaerobacterales	186801|Clostridia	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,POR_N,TPP_enzyme_C
k59_1465742_1	1380394.JADL01000008_gene3744	2.01e-33	124.0	COG2240@1|root,COG2240@2|Bacteria,1MVC9@1224|Proteobacteria,2U2CH@28211|Alphaproteobacteria,2JQ9N@204441|Rhodospirillales	204441|Rhodospirillales	H	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP	pdxY	-	2.7.1.35	ko:K00868	ko00750,ko01100,map00750,map01100	-	R00174,R01909,R02493	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	Phos_pyr_kin
k59_1465742_2	1089552.KI911559_gene595	7.8e-10	58.5	COG2301@1|root,COG2301@2|Bacteria,1MW0A@1224|Proteobacteria,2TTC0@28211|Alphaproteobacteria,2JQKY@204441|Rhodospirillales	204441|Rhodospirillales	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.3.34	ko:K01644	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
k59_1132676_1	1122182.KB903825_gene261	2.84e-11	63.5	COG0167@1|root,COG0167@2|Bacteria,2GKC6@201174|Actinobacteria,4D96V@85008|Micromonosporales	201174|Actinobacteria	F	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor	pyrD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.3.5.2,1.3.98.1	ko:K00226,ko:K00254	ko00240,ko01100,map00240,map01100	M00051	R01867,R01868	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
k59_1132676_2	926550.CLDAP_23750	3.09e-63	209.0	COG0015@1|root,COG0015@2|Bacteria,2G607@200795|Chloroflexi	200795|Chloroflexi	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	-	4.3.2.2,5.5.1.2	ko:K01756,ko:K01857	ko00230,ko00250,ko00362,ko01100,ko01110,ko01120,ko01130,ko01220,map00230,map00250,map00362,map01100,map01110,map01120,map01130,map01220	M00048,M00049	R01083,R03307,R04559	RC00379,RC00444,RC00445,RC00902	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,ASL_C,Lyase_1
k59_965441_1	381764.Fnod_0709	1.68e-20	87.0	COG5405@1|root,COG5405@2|Bacteria,2GCRK@200918|Thermotogae	200918|Thermotogae	O	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery	hslV	-	3.4.25.2	ko:K01419	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Proteasome
k59_965441_2	1089550.ATTH01000001_gene663	1.41e-45	160.0	COG1220@1|root,COG1220@2|Bacteria,4NFI2@976|Bacteroidetes,1FIQI@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	-	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA_2,ClpB_D2-small
k59_965442_1	1038862.KB893841_gene126	1.52e-35	132.0	COG0346@1|root,COG0346@2|Bacteria,1MZT5@1224|Proteobacteria,2U4GS@28211|Alphaproteobacteria,3JUDJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase_3
k59_1465764_1	765913.ThidrDRAFT_3167	2.24e-68	221.0	COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,1RMJN@1236|Gammaproteobacteria,1WVXY@135613|Chromatiales	135613|Chromatiales	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
k59_1688078_1	1304874.JAFY01000007_gene2490	8.67e-46	168.0	COG4251@1|root,COG4936@1|root,COG4251@2|Bacteria,COG4936@2|Bacteria,3TCMP@508458|Synergistetes	2|Bacteria	T	GHKL domain	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GAF,GAF_2,GGDEF,HATPase_c,HD,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,PocR
k59_1021549_1	1382359.JIAL01000001_gene2865	7.07e-66	208.0	COG1136@1|root,COG1136@2|Bacteria,3Y30Q@57723|Acidobacteria,2JI7R@204432|Acidobacteriia	204432|Acidobacteriia	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_186613_1	331869.BAL199_13278	1.22e-70	219.0	COG0454@1|root,COG0454@2|Bacteria,1RDBA@1224|Proteobacteria,2TTF2@28211|Alphaproteobacteria,4BQDP@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	K	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_1410168_1	667632.KB890195_gene3478	5.78e-50	167.0	COG2513@1|root,COG2513@2|Bacteria,1PISN@1224|Proteobacteria,2W9Z1@28216|Betaproteobacteria,1KDWF@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Phosphoenolpyruvate phosphomutase	-	-	-	-	-	-	-	-	-	-	-	-	PEP_mutase
k59_575604_1	1869.MB27_09655	1.53e-11	70.1	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria,4D8KT@85008|Micromonosporales	201174|Actinobacteria	KLT	serine threonine protein kinase	pknL	GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018107,GO:0018193,GO:0018210,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0042304,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
k59_798714_2	1123368.AUIS01000013_gene872	1.24e-49	159.0	COG0198@1|root,COG0198@2|Bacteria,1MZQD@1224|Proteobacteria,1S973@1236|Gammaproteobacteria,2ND3N@225057|Acidithiobacillales	225057|Acidithiobacillales	J	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit	rplX	-	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
k59_798714_3	1415778.JQMM01000001_gene379	1.83e-21	89.0	COG0094@1|root,COG0094@2|Bacteria,1MUU9@1224|Proteobacteria,1RPE1@1236|Gammaproteobacteria,1J50H@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
k59_1354597_1	861299.J421_0057	8.38e-14	68.2	COG0782@1|root,COG0782@2|Bacteria,1ZTPD@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Transcription elongation factor, N-terminal	-	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
k59_20360_1	997346.HMPREF9374_0359	1.11e-66	215.0	COG0686@1|root,COG0686@2|Bacteria,1TNZ5@1239|Firmicutes,4HABX@91061|Bacilli,27B8D@186824|Thermoactinomycetaceae	91061|Bacilli	E	Alanine dehydrogenase/PNT, N-terminal domain	ald	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
k59_75632_1	926569.ANT_27120	8.59e-86	276.0	COG0574@1|root,COG0574@2|Bacteria	2|Bacteria	G	Belongs to the PEP-utilizing enzyme family	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PPDK_N
k59_1132718_1	485913.Krac_8842	1.72e-15	75.9	COG0143@1|root,COG0143@2|Bacteria,2G6VG@200795|Chloroflexi	200795|Chloroflexi	J	Double zinc ribbon	-	-	-	-	-	-	-	-	-	-	-	-	DZR
k59_1132718_2	345341.KUTG_09784	8.4e-33	123.0	COG0299@1|root,COG0299@2|Bacteria,2IGFU@201174|Actinobacteria	201174|Actinobacteria	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	-	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N
k59_1021563_1	861299.J421_3324	1.3e-69	226.0	COG0260@1|root,COG0260@2|Bacteria,1ZSPX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
k59_1743293_1	1379270.AUXF01000004_gene3323	5.85e-126	366.0	COG1484@1|root,COG1484@2|Bacteria,1ZV5D@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Bacterial dnaA  protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
k59_1743293_2	1379270.AUXF01000004_gene3324	4.29e-51	172.0	COG4584@1|root,COG4584@2|Bacteria,1ZV8R@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_465818_1	465541.ATCJ01000005_gene2220	3.2e-08	61.2	COG4191@1|root,COG4191@2|Bacteria,2GMRD@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,cNMP_binding
k59_409449_1	314278.NB231_02243	1.11e-62	204.0	COG3965@1|root,COG3965@2|Bacteria,1MXVG@1224|Proteobacteria,1RSB7@1236|Gammaproteobacteria,1WZ16@135613|Chromatiales	135613|Chromatiales	P	cation diffusion facilitator family transporter	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux
k59_242570_2	861299.J421_0308	2.24e-16	75.9	COG1595@1|root,COG1595@2|Bacteria,1ZTP3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_743195_1	1123519.PSJM300_17900	1.05e-53	175.0	COG2020@1|root,COG2020@2|Bacteria,1N3YJ@1224|Proteobacteria,1SGBM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
k59_967719_1	706587.Desti_2503	1.12e-138	415.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,42PRE@68525|delta/epsilon subdivisions,2WJRD@28221|Deltaproteobacteria,2MRGT@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_1633620_1	1234364.AMSF01000033_gene402	2.98e-80	253.0	COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,1RQE4@1236|Gammaproteobacteria,1X59Z@135614|Xanthomonadales	135614|Xanthomonadales	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	-	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
k59_1468065_1	204669.Acid345_4648	1.52e-06	55.1	COG0745@1|root,COG0745@2|Bacteria,3Y8XM@57723|Acidobacteria	57723|Acidobacteria	T	Domain of unknown function (DUF4388)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4388,Response_reg
k59_1468074_1	765910.MARPU_12930	5.95e-78	249.0	COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,1RMSF@1236|Gammaproteobacteria,1WVW6@135613|Chromatiales	135613|Chromatiales	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
k59_912991_1	861299.J421_3916	3.67e-16	80.5	COG0618@1|root,COG0618@2|Bacteria,1ZSS0@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	DHH family	-	-	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
k59_1579018_1	926569.ANT_01830	1.08e-81	270.0	COG0587@1|root,COG0587@2|Bacteria,2G5IY@200795|Chloroflexi	200795|Chloroflexi	L	TIGRFAM DNA polymerase III, alpha subunit	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_133075_1	1197906.CAJQ02000037_gene4780	2.92e-06	54.3	2DVIF@1|root,33W1T@2|Bacteria,1RIGK@1224|Proteobacteria,2UAQN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	-	-	-	-	-	-	-	-	-	LPG_synthase_TM
k59_1134906_2	1122207.MUS1_15245	1.16e-66	215.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,1RQH6@1236|Gammaproteobacteria,1XN38@135619|Oceanospirillales	135619|Oceanospirillales	G	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_745326_1	948106.AWZT01000002_gene6267	2.36e-10	62.0	COG0210@1|root,COG0210@2|Bacteria	2|Bacteria	L	ATP-dependent DNA helicase activity	helD	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006310,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1902494	3.6.4.12	ko:K03658	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Helicase_IV_N,UvrD-helicase,UvrD_C,zf-C4_Topoisom
k59_1134915_1	1278073.MYSTI_03750	1.24e-37	140.0	COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,42MAR@68525|delta/epsilon subdivisions,2WJEU@28221|Deltaproteobacteria,2YWSR@29|Myxococcales	28221|Deltaproteobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_411630_1	379066.GAU_1670	1.39e-42	147.0	COG0039@1|root,COG0039@2|Bacteria,1ZSV3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	-	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
k59_1078550_1	861299.J421_3786	6.88e-72	229.0	COG0282@1|root,COG0282@2|Bacteria,1ZT9P@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
k59_411636_1	176299.Atu4712	1.3e-07	57.0	COG0745@1|root,COG0745@2|Bacteria,1R7B9@1224|Proteobacteria,2U300@28211|Alphaproteobacteria,4BE5V@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_188915_1	1379270.AUXF01000001_gene2637	7.82e-19	90.9	COG0827@1|root,COG1002@1|root,COG0827@2|Bacteria,COG1002@2|Bacteria,1ZT3Q@142182|Gemmatimonadetes	142182|Gemmatimonadetes	LV	DNA restriction-modification system	-	-	-	-	-	-	-	-	-	-	-	-	N6_Mtase
k59_468030_1	861299.J421_6342	2.14e-40	153.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_1412379_1	1123354.AUDR01000012_gene1618	1.08e-83	259.0	COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,2VI46@28216|Betaproteobacteria	28216|Betaproteobacteria	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	paaK	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
k59_1190007_1	517417.Cpar_0067	7.04e-28	114.0	COG1226@1|root,COG1226@2|Bacteria,1FD8F@1090|Chlorobi	1090|Chlorobi	P	Ion transport 2 domain protein	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2,TrkA_C,TrkA_N
k59_690143_1	886293.Sinac_7530	4.75e-31	123.0	COG0265@1|root,COG0265@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
k59_1190016_1	1088721.NSU_0860	1.75e-88	276.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,2TRBG@28211|Alphaproteobacteria,2K98Y@204457|Sphingomonadales	204457|Sphingomonadales	C	Cytochrome C and Quinol oxidase polypeptide I	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_244732_1	1267534.KB906761_gene1200	1.77e-09	64.3	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_1190021_1	500635.MITSMUL_03634	3.01e-06	53.1	COG0745@1|root,COG0745@2|Bacteria,1TPWS@1239|Firmicutes,4H3DN@909932|Negativicutes	909932|Negativicutes	T	response regulator, receiver	-	-	-	ko:K07658	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_690151_1	1331060.RLDS_14360	0.000358	41.6	COG0203@1|root,COG0203@2|Bacteria,1RCWN@1224|Proteobacteria,2U749@28211|Alphaproteobacteria,2K4J0@204457|Sphingomonadales	204457|Sphingomonadales	J	Ribosomal protein L17	rplQ	-	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
k59_1078598_1	935261.JAGL01000002_gene1440	2.39e-21	92.8	COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,2TRUK@28211|Alphaproteobacteria,43HWQ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Belongs to the peptidase M20A family. ArgE subfamily	argE_1	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
k59_1581285_1	391038.Bphy_4554	9.49e-18	83.2	COG5285@1|root,COG5285@2|Bacteria,1R5SE@1224|Proteobacteria,2VX7E@28216|Betaproteobacteria,1K5J8@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Phytanoyl-CoA dioxygenase (PhyH)	-	-	1.14.11.18	ko:K00477	ko04146,map04146	-	-	-	ko00000,ko00001,ko01000	-	-	-	PhyH
k59_1192159_1	711393.AYRX01000019_gene2108	3.48e-27	115.0	COG1472@1|root,COG1472@2|Bacteria,2GM43@201174|Actinobacteria	201174|Actinobacteria	G	hydrolase, family 3	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3,Glyco_hydro_3_C
k59_246639_1	709032.Sulku_2273	2.16e-28	108.0	COG0081@1|root,COG0081@2|Bacteria,1MUE6@1224|Proteobacteria,42MZP@68525|delta/epsilon subdivisions,2YMN7@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
k59_246639_2	123214.PERMA_1185	2.25e-35	124.0	COG0080@1|root,COG0080@2|Bacteria,2G41D@200783|Aquificae	200783|Aquificae	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
k59_635120_1	1047013.AQSP01000115_gene341	1.41e-88	272.0	COG0673@1|root,COG0673@2|Bacteria,2NQ5E@2323|unclassified Bacteria	2|Bacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_1192180_1	861299.J421_4303	3.71e-55	184.0	COG3386@1|root,COG3386@2|Bacteria	2|Bacteria	G	gluconolactonase activity	gnl	GO:0003674,GO:0003824,GO:0004341,GO:0016787,GO:0016788,GO:0052689	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	SGL
k59_1137149_1	1385517.N800_02080	6.59e-05	46.6	COG1028@1|root,COG1028@2|Bacteria,1MUEV@1224|Proteobacteria,1RNH2@1236|Gammaproteobacteria,1X4C7@135614|Xanthomonadales	135614|Xanthomonadales	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	phbB	-	1.1.1.36	ko:K00023	ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200	M00373	R01779,R01977	RC00103,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	adh_short,adh_short_C2
k59_1137149_2	765420.OSCT_1801	2.44e-14	75.1	COG2379@1|root,COG2379@2|Bacteria,2G5RZ@200795|Chloroflexi,374XG@32061|Chloroflexia	32061|Chloroflexia	C	PFAM MOFRL domain protein	-	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
k59_1026435_1	264198.Reut_B5581	2.08e-28	115.0	COG4398@1|root,COG4398@2|Bacteria,1MUX9@1224|Proteobacteria,2VIY7@28216|Betaproteobacteria,1KBU7@119060|Burkholderiaceae	28216|Betaproteobacteria	S	FIST N domain	-	-	-	-	-	-	-	-	-	-	-	-	FIST,FIST_C
k59_692258_1	1463887.KL589969_gene3569	3.42e-25	107.0	COG5659@1|root,COG5659@2|Bacteria,2GIU9@201174|Actinobacteria	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
k59_525015_1	483219.LILAB_10680	3.43e-48	167.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2YU6E@29|Myxococcales	28221|Deltaproteobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_915557_1	641524.ADICYQ_4554	1.09e-31	128.0	COG4251@1|root,COG4251@2|Bacteria,4NHEM@976|Bacteroidetes,47QEB@768503|Cytophagia	976|Bacteroidetes	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4154,HATPase_c,HisKA,PAS,PAS_9
k59_302739_1	1278309.KB907099_gene2997	4.59e-07	54.3	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RNW9@1236|Gammaproteobacteria,1XHJF@135619|Oceanospirillales	135619|Oceanospirillales	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	doeD	GO:0003674,GO:0003824,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009056,GO:0009987,GO:0016054,GO:0016740,GO:0016769,GO:0019752,GO:0032787,GO:0042399,GO:0042400,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0045303,GO:0046395,GO:0046483,GO:0046700,GO:0071704,GO:0072329,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575	2.6.1.76	ko:K15785	ko00260,map00260	-	R06977	RC00006,RC00062	ko00000,ko00001,ko01000	-	-	-	Aminotran_3
k59_747477_1	1232410.KI421413_gene649	1.13e-43	160.0	COG0845@1|root,COG0845@2|Bacteria,1MVAS@1224|Proteobacteria,42PKU@68525|delta/epsilon subdivisions,2WM5K@28221|Deltaproteobacteria,43SBG@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	HlyD family secretion protein	-	-	-	ko:K07798,ko:K15727	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4,8.A.1,8.A.1.2.1	-	-	DUF3347,HlyD_D23
k59_1693043_1	1054860.KB913030_gene2918	2.68e-10	58.9	COG1324@1|root,COG1324@2|Bacteria,2IQF1@201174|Actinobacteria	201174|Actinobacteria	P	Divalent ion tolerance protein	-	-	-	ko:K03926	-	-	-	-	ko00000	-	-	-	CutA1
k59_191040_1	1121451.DESAM_21057	5.75e-10	60.5	COG1664@1|root,COG1664@2|Bacteria,1N7TF@1224|Proteobacteria,42VWZ@68525|delta/epsilon subdivisions,2WRPF@28221|Deltaproteobacteria,2MBWU@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
k59_1080791_1	1047013.AQSP01000033_gene1388	1.89e-14	74.3	COG0668@1|root,COG0668@2|Bacteria,2NPY4@2323|unclassified Bacteria	2|Bacteria	M	Mechanosensitive ion channel	-	-	-	ko:K22044	-	-	-	-	ko00000,ko02000	1.A.23.3	-	-	MS_channel
k59_635186_1	235985.BBPN01000025_gene1855	3.7e-40	145.0	COG1319@1|root,COG1319@2|Bacteria,2GT14@201174|Actinobacteria,2NEC7@228398|Streptacidiphilus	201174|Actinobacteria	C	CO dehydrogenase flavoprotein C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	CO_deh_flav_C,FAD_binding_5
k59_413832_1	706587.Desti_3139	9.02e-82	263.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,42M80@68525|delta/epsilon subdivisions,2WINJ@28221|Deltaproteobacteria,2MQIA@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Belongs to the transketolase family	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
k59_1414451_1	935840.JAEQ01000018_gene2029	3.51e-72	231.0	COG0404@1|root,COG0404@2|Bacteria,1MWZS@1224|Proteobacteria,2TSVD@28211|Alphaproteobacteria,43JE4@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Aminomethyltransferase folate-binding domain	-	-	-	ko:K15064	ko00627,ko01120,map00627,map01120	-	R09270	RC00113,RC00392	ko00000,ko00001,ko01000	-	-	-	GCV_T,GCV_T_C
k59_915590_1	1267534.KB906757_gene967	2.12e-26	112.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_80097_1	991905.SL003B_2021	1.52e-85	264.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,2TQXI@28211|Alphaproteobacteria,4BPQT@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	H	Aminotransferase class I and II	hemA	-	2.3.1.37	ko:K00643	ko00260,ko00860,ko01100,ko01110,map00260,map00860,map01100,map01110	-	R00830	RC00004,RC02815	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_24838_1	452637.Oter_1855	5.17e-30	122.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_857356_1	234267.Acid_6762	0.000825	46.6	COG1361@1|root,COG3055@1|root,COG1361@2|Bacteria,COG3055@2|Bacteria,3Y6HA@57723|Acidobacteria	2|Bacteria	M	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	Collagen_bind_2,DUF11,DUF5060,Kelch_1,Kelch_6,NPCBM
k59_692311_1	1286632.P278_18900	2.52e-69	218.0	COG3618@1|root,COG3618@2|Bacteria,4NFGB@976|Bacteroidetes,1HYCT@117743|Flavobacteriia	976|Bacteroidetes	S	amidohydrolase	-	-	-	ko:K07046	ko00051,ko01120,map00051,map01120	-	R10689	RC00537	ko00000,ko00001,ko01000	-	-	-	Amidohydro_2
k59_692311_2	391596.PBAL39_05423	2.07e-13	69.3	COG0179@1|root,COG0179@2|Bacteria,4NFMZ@976|Bacteroidetes,1IPCE@117747|Sphingobacteriia	976|Bacteroidetes	Q	PFAM Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
k59_1192254_1	383372.Rcas_0411	1.36e-157	454.0	COG3385@1|root,COG3385@2|Bacteria,2G8GC@200795|Chloroflexi,3768R@32061|Chloroflexia	32061|Chloroflexia	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_1359125_1	682795.AciX8_1966	2.15e-12	65.5	COG1438@1|root,COG1438@2|Bacteria	2|Bacteria	K	arginine binding	argR	GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141	-	ko:K03402	-	-	-	-	ko00000,ko03000	-	-	-	Arg_repressor,Arg_repressor_C
k59_1359125_2	65489.OBART12G06860.2	2.73e-59	199.0	COG0137@1|root,KOG1706@2759|Eukaryota,37QUX@33090|Viridiplantae,3G8Y6@35493|Streptophyta,3KP3Q@4447|Liliopsida,3IAWK@38820|Poales	35493|Streptophyta	E	Arginosuccinate synthase	-	GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
k59_1693085_1	1123052.AUDF01000012_gene821	8.24e-30	121.0	COG1131@1|root,COG1131@2|Bacteria,2IAM9@201174|Actinobacteria,4FTDS@85023|Microbacteriaceae	201174|Actinobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_857362_1	986075.CathTA2_0183	9.57e-35	136.0	COG2217@1|root,COG2217@2|Bacteria,1TQ07@1239|Firmicutes,4H9SP@91061|Bacilli	91061|Bacilli	P	COG2217 Cation transport ATPase	-	-	-	-	-	-	-	-	-	-	-	-	E1-E2_ATPase,Hydrolase
k59_692316_1	861299.J421_1355	1.47e-32	130.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_1249552_1	383372.Rcas_1029	4.17e-82	255.0	COG1215@1|root,COG1215@2|Bacteria,2GBN6@200795|Chloroflexi	200795|Chloroflexi	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_191076_1	861299.J421_1935	1.56e-49	177.0	COG2091@1|root,COG2091@2|Bacteria,1ZU9H@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1470528_1	1521187.JPIM01000084_gene671	6.59e-36	138.0	COG0442@1|root,COG0442@2|Bacteria,2G5Q6@200795|Chloroflexi,374ZE@32061|Chloroflexia	32061|Chloroflexia	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	-	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
k59_80111_1	234267.Acid_4270	6.61e-48	176.0	COG4447@1|root,COG4447@2|Bacteria,3Y487@57723|Acidobacteria	57723|Acidobacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_692322_1	867903.ThesuDRAFT_02018	4.16e-79	249.0	COG1319@1|root,COG1319@2|Bacteria,1TQA5@1239|Firmicutes,248WI@186801|Clostridia	186801|Clostridia	C	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
k59_747530_2	196367.JNFG01000003_gene5684	1.92e-17	84.0	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,2VJAS@28216|Betaproteobacteria,1K0R7@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_804803_1	925409.KI911562_gene1594	3.43e-56	193.0	COG1472@1|root,COG1472@2|Bacteria,4NE90@976|Bacteroidetes,1IVNE@117747|Sphingobacteriia	976|Bacteroidetes	G	Glycosyl hydrolase family 3 C-terminal domain	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	F5_F8_type_C,Glyco_hydro_3,Glyco_hydro_3_C,fn3
k59_1138998_1	935840.JAEQ01000001_gene2685	2.18e-106	328.0	COG2225@1|root,COG2225@2|Bacteria,1MVEV@1224|Proteobacteria,2TS9R@28211|Alphaproteobacteria,43H25@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA	glcB	-	2.3.3.9	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472	RC00004,RC00308,RC02747	ko00000,ko00001,ko00002,ko01000	-	-	-	Malate_synthase
k59_694199_1	379066.GAU_2347	2.24e-13	71.2	COG0541@1|root,COG0541@2|Bacteria,1ZSPG@142182|Gemmatimonadetes	142182|Gemmatimonadetes	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
k59_694199_2	555088.DealDRAFT_1976	1.47e-14	67.8	COG0228@1|root,COG0228@2|Bacteria,1VA0X@1239|Firmicutes,24MND@186801|Clostridia,42K3P@68298|Syntrophomonadaceae	186801|Clostridia	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	-	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
k59_248414_2	331869.BAL199_27970	9.36e-45	147.0	COG0640@1|root,COG0640@2|Bacteria,1MZAU@1224|Proteobacteria,2UBVH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
k59_859059_1	309807.SRU_2821	1.63e-16	82.0	COG4805@1|root,COG4805@2|Bacteria,4NFAK@976|Bacteroidetes,1FKD5@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
k59_1028469_1	1492738.FEM21_21320	0.000137	47.8	2DR9X@1|root,33AUW@2|Bacteria,4PCJX@976|Bacteroidetes,1ID5B@117743|Flavobacteriia,2NXDK@237|Flavobacterium	976|Bacteroidetes	S	PrcB C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	PrcB_C
k59_526801_1	593105.S7A_00360	7.63e-42	149.0	COG3618@1|root,COG3618@2|Bacteria,1N2QM@1224|Proteobacteria,1RQ8V@1236|Gammaproteobacteria,3W11M@53335|Pantoea	1236|Gammaproteobacteria	S	to Burkholderia multivorans CGD2M, amidohydrolase 2 (NCBI ZP_03573566.1)	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2,FCD,GntR
k59_359527_1	883080.HMPREF9697_00539	6.43e-46	158.0	COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,2TS3R@28211|Alphaproteobacteria,3JQY9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
k59_859070_1	2055.JNXA01000018_gene3559	4.24e-08	58.9	COG0318@1|root,COG0318@2|Bacteria,2GKZ6@201174|Actinobacteria,4GBJS@85026|Gordoniaceae	201174|Actinobacteria	IQ	AMP-binding enzyme C-terminal domain	fadD6	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_526805_1	1444306.JFZC01000031_gene2764	8.5e-25	100.0	COG0204@1|root,COG0204@2|Bacteria,1U8N2@1239|Firmicutes,4HDQR@91061|Bacilli,26NX4@186821|Sporolactobacillaceae	91061|Bacilli	I	Phosphate acyltransferases	plsC	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
k59_526805_2	443152.MDG893_08920	3.05e-05	46.6	COG0283@1|root,COG0283@2|Bacteria,1MUUD@1224|Proteobacteria,1RNKT@1236|Gammaproteobacteria,466NJ@72275|Alteromonadaceae	1236|Gammaproteobacteria	F	Belongs to the cytidylate kinase family. Type 1 subfamily	cmk	GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0015939,GO:0015940,GO:0015949,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iPC815.YPO1391,iSDY_1059.SDY_2348	Cytidylate_kin
k59_1416144_1	1340434.AXVA01000012_gene2953	1.94e-33	130.0	COG5016@1|root,COG5016@2|Bacteria,1VT8P@1239|Firmicutes,4HBJ1@91061|Bacilli	91061|Bacilli	C	Conserved carboxylase domain	oadA	-	4.1.1.3	ko:K01571	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	HMGL-like,PYC_OADA
k59_1472392_1	1380387.JADM01000008_gene1028	1.16e-20	89.0	COG1028@1|root,COG1028@2|Bacteria,1MWBC@1224|Proteobacteria,1RNNV@1236|Gammaproteobacteria,1XH47@135619|Oceanospirillales	135619|Oceanospirillales	IQ	reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_137090_1	926569.ANT_18220	5.91e-50	165.0	COG1143@1|root,COG1143@2|Bacteria,2G6SE@200795|Chloroflexi	200795|Chloroflexi	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.6.5.3	ko:K00338,ko:K03615	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
k59_248465_1	1288826.MSNKSG1_04681	9.96e-53	172.0	COG4221@1|root,COG4221@2|Bacteria,1PWXN@1224|Proteobacteria,1S226@1236|Gammaproteobacteria,4671I@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4336)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4336
k59_415655_2	313606.M23134_02981	2.16e-24	106.0	COG0642@1|root,COG2205@2|Bacteria,4NN26@976|Bacteroidetes,47U6C@768503|Cytophagia	976|Bacteroidetes	T	7TM diverse intracellular signalling	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISM_7TM,HATPase_c,HisKA
k59_917674_1	570967.JMLV01000002_gene1983	4.61e-73	245.0	COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,2TQRR@28211|Alphaproteobacteria,2JPD6@204441|Rhodospirillales	204441|Rhodospirillales	L	This protein is involved in the repair of mismatches in DNA	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
k59_248477_1	411684.HPDFL43_03536	1.78e-24	104.0	COG4233@1|root,COG4233@2|Bacteria,1NF38@1224|Proteobacteria,2TVYG@28211|Alphaproteobacteria,43J60@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	CO	Disulphide bond corrector protein DsbC	-	-	-	-	-	-	-	-	-	-	-	-	DsbC
k59_1749136_1	335543.Sfum_2673	6.51e-34	127.0	COG5660@1|root,2Z7TM@2|Bacteria,1PMCV@1224|Proteobacteria,42Q81@68525|delta/epsilon subdivisions,2WIJ3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	TRAP transporter T-component	-	-	-	-	-	-	-	-	-	-	-	-	TAtT
k59_359580_1	309801.trd_1942	5.34e-41	149.0	COG1063@1|root,COG1063@2|Bacteria,2G7NV@200795|Chloroflexi,27Y3N@189775|Thermomicrobia	189775|Thermomicrobia	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
k59_804879_2	1319815.HMPREF0202_01653	1.61e-45	157.0	COG0573@1|root,COG0573@2|Bacteria,3795Q@32066|Fusobacteria	32066|Fusobacteria	P	probably responsible for the translocation of the substrate across the membrane	pstC	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
k59_1695026_1	1177594.MIC448_70002	6.3e-26	100.0	2DTH9@1|root,33KBD@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4262)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4262
k59_1695026_2	272952.HpaP806408	2.54e-19	87.0	COG0141@1|root,KOG2697@2759|Eukaryota,3QAS9@4776|Peronosporales	4776|Peronosporales	E	Histidinol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Histidinol_dh
k59_472629_1	1121289.JHVL01000002_gene2370	5.14e-14	73.6	COG1234@1|root,COG1234@2|Bacteria,1V1TF@1239|Firmicutes,25CI5@186801|Clostridia,36WWI@31979|Clostridiaceae	186801|Clostridia	S	Metallo-beta-lactamase superfamily	ElaC	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
k59_472629_2	335541.Swol_1278	9.08e-22	92.4	COG0284@1|root,COG0284@2|Bacteria,1TPPH@1239|Firmicutes,24DII@186801|Clostridia,42JUF@68298|Syntrophomonadaceae	186801|Clostridia	F	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)	pyrF	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
k59_1637554_1	234267.Acid_5780	2.91e-32	129.0	COG0515@1|root,COG3899@1|root,COG0515@2|Bacteria,COG3899@2|Bacteria	2|Bacteria	T	PFAM Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	AAA_16,BTAD,TPR_12,TPR_8,Trans_reg_C
k59_749246_1	1380355.JNIJ01000013_gene377	9.64e-55	189.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria,3JR7R@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_1695055_1	926569.ANT_13770	4.03e-90	280.0	COG0056@1|root,COG0056@2|Bacteria,2G5YQ@200795|Chloroflexi	200795|Chloroflexi	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
k59_1472467_1	768671.ThimaDRAFT_0119	1.52e-08	55.5	COG1216@1|root,COG2246@1|root,COG1216@2|Bacteria,COG2246@2|Bacteria,1MV8J@1224|Proteobacteria,1S1IR@1236|Gammaproteobacteria,1WW4E@135613|Chromatiales	135613|Chromatiales	M	glycosyl transferase family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2,GtrA
k59_472674_1	113395.AXAI01000058_gene6209	1.73e-95	280.0	COG3335@1|root,COG3335@2|Bacteria,1MW7X@1224|Proteobacteria,2U9ZP@28211|Alphaproteobacteria,3K0MT@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
k59_1361021_1	1242864.D187_002552	1.08e-24	108.0	COG0318@1|root,COG0318@2|Bacteria,1PH7B@1224|Proteobacteria,42TTG@68525|delta/epsilon subdivisions,2WQEX@28221|Deltaproteobacteria,2YU8V@29|Myxococcales	28221|Deltaproteobacteria	IQ	GH3 auxin-responsive promoter	-	-	-	-	-	-	-	-	-	-	-	-	GH3
k59_1695088_1	292563.Cyast_1470	4.99e-13	73.6	COG0595@1|root,COG0595@2|Bacteria,1G0MZ@1117|Cyanobacteria	1117|Cyanobacteria	J	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,RMMBL
k59_26644_1	68219.JNXI01000022_gene3754	5.33e-23	91.3	COG0346@1|root,COG0346@2|Bacteria,2IHQQ@201174|Actinobacteria	201174|Actinobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
k59_26644_2	1114959.SZMC14600_23380	6.22e-42	139.0	COG0640@1|root,COG0640@2|Bacteria,2GNW2@201174|Actinobacteria,4E5R7@85010|Pseudonocardiales	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
k59_1139149_1	1240349.ANGC01000039_gene4428	9.91e-52	179.0	COG2072@1|root,COG2072@2|Bacteria,2GJTC@201174|Actinobacteria,4FVQ6@85025|Nocardiaceae	201174|Actinobacteria	P	flavoprotein involved in K transport	-	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	NAD_binding_8
k59_1251372_1	1121374.KB891590_gene1661	4.57e-19	90.9	COG1538@1|root,COG1538@2|Bacteria,1NW1T@1224|Proteobacteria,1RPGN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	MU	outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_917776_1	472759.Nhal_0351	3.44e-73	233.0	COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,1RMZD@1236|Gammaproteobacteria,1WX79@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
k59_137187_2	1306990.BARG01000038_gene4472	2e-25	102.0	COG2259@1|root,COG2259@2|Bacteria,2IJ0I@201174|Actinobacteria	201174|Actinobacteria	S	DoxX	-	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
k59_359671_1	66269.NL54_13665	8.43e-50	172.0	COG2220@1|root,COG2220@2|Bacteria,1MV20@1224|Proteobacteria,1RN4Z@1236|Gammaproteobacteria,3VZYR@53335|Pantoea	1236|Gammaproteobacteria	S	Beta-lactamase superfamily domain	-	-	3.1.4.54	ko:K13985	ko04723,map04723	-	-	-	ko00000,ko00001,ko01000	-	-	-	Lactamase_B_2
k59_1194172_1	1122603.ATVI01000005_gene3498	2.95e-34	132.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1SZ6C@1236|Gammaproteobacteria,1XCCV@135614|Xanthomonadales	1236|Gammaproteobacteria	T	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,TPR_19,TPR_2,TPR_8
k59_1695130_1	337191.KTR9_1850	6.44e-35	132.0	COG0083@1|root,COG0083@2|Bacteria,2GKIW@201174|Actinobacteria,4GBEA@85026|Gordoniaceae	201174|Actinobacteria	E	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate	thrB	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004413,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006566,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009088,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019202,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.1.39	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
k59_637179_1	1469245.JFBG01000016_gene989	3.51e-155	459.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,1RN40@1236|Gammaproteobacteria,1X2WW@135613|Chromatiales	1236|Gammaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	yagR	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016903,GO:0030151,GO:0033554,GO:0042597,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114	1.17.1.4	ko:K11177	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_917815_2	395494.Galf_0178	4.09e-20	87.0	293CN@1|root,2ZQV6@2|Bacteria,1QVH7@1224|Proteobacteria,2WGR5@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_359700_1	717785.HYPMC_0685	1.72e-19	84.0	COG2087@1|root,COG2087@2|Bacteria,1RH0A@1224|Proteobacteria,2U98X@28211|Alphaproteobacteria,3N76F@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate	cobP	-	2.7.1.156,2.7.7.62	ko:K02231	ko00860,ko01100,map00860,map01100	M00122	R05221,R05222,R06558	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	CobU
k59_359700_2	1500301.JQMF01000004_gene3380	6.06e-14	73.6	COG0523@1|root,COG0523@2|Bacteria,1MVZV@1224|Proteobacteria,2TQWN@28211|Alphaproteobacteria,4BAEQ@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	cobalamin biosynthesis protein CobW	cobW	-	-	ko:K02234	-	-	-	-	ko00000,ko00001	-	-	-	CobW_C,cobW
k59_694421_1	861299.J421_0677	1.27e-129	399.0	COG0841@1|root,COG0841@2|Bacteria	2|Bacteria	V	transmembrane transporter activity	acrB	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_415781_1	1321786.HMPREF1992_01657	2.96e-15	79.0	COG0795@1|root,COG0795@2|Bacteria,1TRZG@1239|Firmicutes,4H2PV@909932|Negativicutes	909932|Negativicutes	S	Permease, YjgP YjgQ family	lptG	-	-	ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
k59_82187_1	452863.Achl_3136	3.02e-28	116.0	COG4948@1|root,COG4948@2|Bacteria,2GKSK@201174|Actinobacteria,1WAQG@1268|Micrococcaceae	201174|Actinobacteria	M	mandelate racemase muconate lactonizing	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
k59_248604_1	1089552.KI911559_gene2948	1.16e-78	245.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TQJC@28211|Alphaproteobacteria,2JPJV@204441|Rhodospirillales	204441|Rhodospirillales	EP	COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_26712_1	1120705.FG95_02967	1.65e-69	218.0	COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,2TRGY@28211|Alphaproteobacteria,2K0MX@204457|Sphingomonadales	204457|Sphingomonadales	L	Bacterial dnaA  protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
k59_26712_2	1123269.NX02_20110	1.36e-09	58.9	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2TQKF@28211|Alphaproteobacteria,2K2UN@204457|Sphingomonadales	204457|Sphingomonadales	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_1305667_1	38833.XP_003064665.1	6.59e-05	50.8	COG0443@1|root,COG0457@1|root,KOG0101@2759|Eukaryota,KOG0548@2759|Eukaryota,37HJ7@33090|Viridiplantae,34P3G@3041|Chlorophyta	3041|Chlorophyta	O	heat shock protein 70	-	-	-	ko:K03283	ko03040,ko04010,ko04141,ko04144,ko04213,ko04612,ko04915,ko05134,ko05145,ko05162,ko05164,ko05169,map03040,map04010,map04141,map04144,map04213,map04612,map04915,map05134,map05145,map05162,map05164,map05169	M00353,M00355	-	-	ko00000,ko00001,ko00002,ko01009,ko03009,ko03029,ko03041,ko03051,ko03110,ko04131,ko04147,ko04516	1.A.33.1	-	-	HSP70
k59_1583315_1	1144305.PMI02_05082	1.74e-178	504.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,2K36C@204457|Sphingomonadales	204457|Sphingomonadales	L	Transposase IS116/IS110/IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_472782_1	1244869.H261_22663	1.7e-75	233.0	COG3677@1|root,COG3677@2|Bacteria,1MXYX@1224|Proteobacteria	1224|Proteobacteria	L	Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1595,Zn_Tnp_IS1595
k59_694457_1	795359.TOPB45_0247	5.62e-15	80.1	COG0755@1|root,COG0755@2|Bacteria,2GGYG@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	O	Cytochrome C assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
k59_694459_1	926550.CLDAP_17630	2.4e-112	339.0	COG1884@1|root,COG1884@2|Bacteria,2G62T@200795|Chloroflexi	200795|Chloroflexi	I	TIGRFAM methylmalonyl-CoA mutase, large subunit	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
k59_917873_1	66897.DJ64_31615	3.56e-24	103.0	COG1879@1|root,COG1879@2|Bacteria,2GJ0Z@201174|Actinobacteria	201174|Actinobacteria	G	Periplasmic binding protein LacI transcriptional regulator	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
k59_415818_1	926569.ANT_11480	6.94e-59	196.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	yghO	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_1305691_1	665571.STHERM_c04240	9.3e-30	117.0	COG1052@1|root,COG1052@2|Bacteria	2|Bacteria	CH	NAD binding	-	-	1.1.1.399,1.1.1.95	ko:K00058,ko:K04496	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,ko04310,ko04330,ko05200,ko05220,map00260,map00680,map01100,map01120,map01130,map01200,map01230,map04310,map04330,map05200,map05220	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_1194251_2	318167.Sfri_1020	2.86e-32	126.0	COG2204@1|root,COG3829@1|root,COG2204@2|Bacteria,COG3829@2|Bacteria,1MU0N@1224|Proteobacteria,1T1IW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GAF_2,GGDEF,HTH_8,Sigma54_activat,V4R,XylR_N
k59_1527587_1	1163409.UUA_15428	1.69e-40	155.0	COG2937@1|root,COG2937@2|Bacteria,1MWZ6@1224|Proteobacteria,1RM7K@1236|Gammaproteobacteria,1X4M7@135614|Xanthomonadales	135614|Xanthomonadales	I	Belongs to the GPAT DAPAT family	plsB	-	2.3.1.15	ko:K00631	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
k59_82256_1	243090.RB5028	6.48e-32	129.0	COG0470@1|root,COG0515@1|root,COG1262@1|root,COG0470@2|Bacteria,COG0515@2|Bacteria,COG1262@2|Bacteria,2IY3E@203682|Planctomycetes	203682|Planctomycetes	KLT	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,Pkinase
k59_749395_2	324602.Caur_1423	1.7e-22	96.3	COG1475@1|root,COG1475@2|Bacteria,2G6EK@200795|Chloroflexi,375IS@32061|Chloroflexia	32061|Chloroflexia	K	PFAM ParB domain protein nuclease	-	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
k59_806651_2	391603.FBALC1_01427	1.01e-17	80.9	COG1186@1|root,COG1186@2|Bacteria,4NQ41@976|Bacteroidetes,1I3Z8@117743|Flavobacteriia	976|Bacteroidetes	J	chain release factor	arfB	-	-	ko:K15034	-	-	-	-	ko00000,ko03012	-	-	-	RF-1
k59_1585048_1	861299.J421_6291	1.24e-88	275.0	COG0004@1|root,COG0004@2|Bacteria,1ZT74@142182|Gemmatimonadetes	142182|Gemmatimonadetes	U	Ammonium Transporter Family	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_361412_1	997346.HMPREF9374_0401	2.57e-16	82.4	COG3328@1|root,COG3328@2|Bacteria,1W73S@1239|Firmicutes,4HXXN@91061|Bacilli,27D8K@186824|Thermoactinomycetaceae	91061|Bacilli	L	MULE transposase domain	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_194878_2	1504319.GM45_5420	1.91e-19	85.9	COG0623@1|root,COG0623@2|Bacteria,2GJ65@201174|Actinobacteria	201174|Actinobacteria	I	Enoyl- acyl-carrier-protein reductase NADH	inhA	GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0005488,GO:0005504,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0009058,GO:0009059,GO:0009273,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030312,GO:0030497,GO:0031406,GO:0032787,GO:0033293,GO:0034645,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043436,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0070403,GO:0070589,GO:0071554,GO:0071704,GO:0071766,GO:0071767,GO:0071768,GO:0071840,GO:0071944,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576	1.3.1.10,1.3.1.9	ko:K00208,ko:K11611	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_417473_2	1347393.HG726021_gene485	1.71e-16	78.6	297A5@1|root,2ZUHQ@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4145)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4145
k59_1030609_1	767817.Desgi_4251	9.27e-97	315.0	COG0574@1|root,COG0587@1|root,COG3848@1|root,COG0574@2|Bacteria,COG0587@2|Bacteria,COG3848@2|Bacteria,1UIEA@1239|Firmicutes,25EJM@186801|Clostridia,260AR@186807|Peptococcaceae	186801|Clostridia	GT	Pyruvate phosphate dikinase, PEP	ppdK	-	2.7.9.1,2.7.9.2	ko:K01006,ko:K01007	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173,M00374	R00199,R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_83911_1	861299.J421_1620	3.08e-143	419.0	COG3669@1|root,COG3669@2|Bacteria,1ZURK@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Alpha-L-fucosidase	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos
k59_1417967_1	525904.Tter_1226	1.92e-12	66.6	COG0492@1|root,COG0492@2|Bacteria,2NNS7@2323|unclassified Bacteria	2|Bacteria	O	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	GO:0000166,GO:0001666,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019725,GO:0036094,GO:0036293,GO:0040007,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070402,GO:0070482,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748	1.8.1.9	ko:K00384,ko:K03671	ko00450,ko04621,ko05418,map00450,map04621,map05418	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000,ko03110	-	-	iNJ661.Rv3913	Pyr_redox_2
k59_1417967_2	1278073.MYSTI_02808	3.44e-31	122.0	COG3342@1|root,COG3342@2|Bacteria,1MWQT@1224|Proteobacteria	1224|Proteobacteria	S	major pilin protein fima	MA20_16755	-	-	-	-	-	-	-	-	-	-	-	DUF1028
k59_1696945_1	588581.Cpap_3957	2.98e-67	222.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,3WGVP@541000|Ruminococcaceae	186801|Clostridia	V	ABC-type multidrug transport system ATPase and permease	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_1529188_1	273057.SSO2130	1.29e-63	206.0	COG1013@1|root,arCOG01601@2157|Archaea,2XPVE@28889|Crenarchaeota	28889|Crenarchaeota	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
k59_417501_1	379066.GAU_1570	1.83e-56	181.0	COG0615@1|root,COG0615@2|Bacteria,1ZTPI@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	-	-	-	-	-	-	-	-	-	-	-	-	CTP_transf_like
k59_417501_2	1869.MB27_01710	0.000456	42.4	COG0689@1|root,COG0689@2|Bacteria,2GJFI@201174|Actinobacteria,4DC2I@85008|Micromonosporales	201174|Actinobacteria	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575	2.7.7.56	ko:K00989	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_PH,RNase_PH_C
k59_638884_1	706587.Desti_4901	2.34e-17	83.2	COG0420@1|root,COG0420@2|Bacteria	2|Bacteria	L	3'-5' exonuclease activity	-	-	3.1.1.53	ko:K03547,ko:K05970	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Metallophos,Metallophos_2
k59_1696955_1	1117318.PRUB_21128	1.3e-63	204.0	COG3541@1|root,COG3541@2|Bacteria,1MYFT@1224|Proteobacteria,1RY9F@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	nucleotidyltransferase	-	-	-	ko:K07074	-	-	-	-	ko00000	-	-	-	Nuc-transf
k59_138876_1	1255043.TVNIR_2358	5.49e-55	187.0	COG1173@1|root,COG1173@2|Bacteria,1R4K8@1224|Proteobacteria,1SYV4@1236|Gammaproteobacteria,1X02Z@135613|Chromatiales	135613|Chromatiales	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_1750918_2	373903.Hore_02570	5.53e-25	106.0	COG0577@1|root,COG0577@2|Bacteria,1TPUU@1239|Firmicutes,2483J@186801|Clostridia,3WBQF@53433|Halanaerobiales	186801|Clostridia	V	ABC-type antimicrobial peptide transport system, permease component	macB_8	-	-	ko:K02004,ko:K16918	ko02010,map02010	M00258,M00584	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_1195972_1	1121013.P873_07000	3.21e-46	169.0	COG0790@1|root,COG4249@1|root,COG0790@2|Bacteria,COG4249@2|Bacteria,1MWPA@1224|Proteobacteria,1RRKA@1236|Gammaproteobacteria,1XC91@135614|Xanthomonadales	135614|Xanthomonadales	S	Caspase domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14,Sel1
k59_1417989_1	1382359.JIAL01000001_gene88	3.56e-62	202.0	COG0821@1|root,COG0821@2|Bacteria,3Y2GU@57723|Acidobacteria,2JHND@204432|Acidobacteriia	204432|Acidobacteriia	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
k59_1195973_1	485913.Krac_10516	3.49e-109	327.0	COG0505@1|root,COG0505@2|Bacteria,2G5S1@200795|Chloroflexi	200795|Chloroflexi	F	Belongs to the CarA family	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
k59_1696983_1	861299.J421_6339	3.91e-97	300.0	COG3507@1|root,COG3507@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 43 family	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C,Glyco_hydro_43
k59_696324_1	1459636.NTE_02391	7.2e-22	97.4	COG0677@1|root,arCOG00252@2157|Archaea	2157|Archaea	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.336	ko:K02472	ko00520,ko05111,map00520,map05111	-	R03317	RC00291	ko00000,ko00001,ko01000	-	-	-	NAD_binding_2,UDPG_MGDP_dh,UDPG_MGDP_dh_C
k59_474710_1	247633.GP2143_12386	1.94e-43	152.0	COG1072@1|root,COG1072@2|Bacteria,1MV3M@1224|Proteobacteria,1RNXX@1236|Gammaproteobacteria,1J7UU@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Pantothenic acid kinase	coaA	GO:0003674,GO:0003824,GO:0004594,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.33	ko:K00867	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	iECDH1ME8569_1439.ECDH1ME8569_3838,iECH74115_1262.ECH74115_5439,iECSE_1348.ECSE_4265,iECSF_1327.ECSF_3833,iECSP_1301.ECSP_5045,iECW_1372.ECW_m4332,iEcDH1_1363.EcDH1_4016,iEcolC_1368.EcolC_4046,iPC815.YPO3758,iSFV_1184.SFV_4047,iSFxv_1172.SFxv_4418,iWFL_1372.ECW_m4332,iZ_1308.Z5545	PRK
k59_474710_2	710686.Mycsm_06463	1.68e-09	58.9	COG2114@1|root,COG2267@1|root,COG2114@2|Bacteria,COG2267@2|Bacteria,2IASU@201174|Actinobacteria,232Z7@1762|Mycobacteriaceae	201174|Actinobacteria	IT	PFAM Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Guanylate_cyc
k59_1696988_2	926569.ANT_24750	1.03e-49	164.0	COG2010@1|root,COG2010@2|Bacteria,2G7FH@200795|Chloroflexi	200795|Chloroflexi	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
k59_1195992_2	105559.Nwat_2181	1.65e-58	184.0	COG0080@1|root,COG0080@2|Bacteria,1RA2M@1224|Proteobacteria,1S22R@1236|Gammaproteobacteria,1WXZD@135613|Chromatiales	135613|Chromatiales	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	-	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
k59_1529234_1	765913.ThidrDRAFT_0056	6.4e-75	236.0	COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,1RMCS@1236|Gammaproteobacteria,1WWP0@135613|Chromatiales	135613|Chromatiales	E	Belongs to the DegT DnrJ EryC1 family	-	-	2.6.1.98	ko:K13017	ko00520,map00520	-	R10141	RC00006,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	DegT_DnrJ_EryC1
k59_1362882_1	765420.OSCT_2101	3.18e-14	71.6	COG2303@1|root,COG2303@2|Bacteria,2G7EB@200795|Chloroflexi	200795|Chloroflexi	E	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
k59_1362882_2	485913.Krac_3059	2.29e-71	231.0	COG3844@1|root,COG3844@2|Bacteria,2G5K1@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively	kynU	-	3.7.1.3	ko:K01556	ko00380,ko01100,map00380,map01100	M00038	R00987,R02668,R03936	RC00284,RC00415	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5
k59_417553_1	469383.Cwoe_4655	3.96e-12	71.2	COG0500@1|root,COG2226@2|Bacteria,2HPV9@201174|Actinobacteria,4CR9D@84995|Rubrobacteria	84995|Rubrobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_919782_1	1116369.KB890024_gene60	5.43e-62	216.0	COG3290@1|root,COG5001@1|root,COG3290@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TV0G@28211|Alphaproteobacteria,43RVC@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_4,PAS_7
k59_1362892_1	926561.KB900621_gene2826	5.9e-19	87.4	COG1683@1|root,COG3272@1|root,COG1683@2|Bacteria,COG3272@2|Bacteria,1TQX3@1239|Firmicutes,24A3W@186801|Clostridia,3WB7V@53433|Halanaerobiales	186801|Clostridia	S	Protein of unknown function (DUF1722)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1722,DUF523
k59_1697017_1	926569.ANT_01830	5.11e-70	237.0	COG0587@1|root,COG0587@2|Bacteria,2G5IY@200795|Chloroflexi	200795|Chloroflexi	L	TIGRFAM DNA polymerase III, alpha subunit	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_1196025_1	118161.KB235922_gene1117	7.58e-69	222.0	COG0304@1|root,COG0304@2|Bacteria,1G1J5@1117|Cyanobacteria,3VIR6@52604|Pleurocapsales	1117|Cyanobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_1418050_1	69279.BG36_15520	5.52e-60	207.0	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,2TRGS@28211|Alphaproteobacteria,43IB9@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Belongs to the GcvT family	Sardh	GO:0000166,GO:0001505,GO:0003674,GO:0003824,GO:0005488,GO:0005542,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006520,GO:0006575,GO:0006576,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008480,GO:0009056,GO:0009063,GO:0009308,GO:0009310,GO:0009987,GO:0016054,GO:0016491,GO:0016645,GO:0019695,GO:0019752,GO:0019842,GO:0031406,GO:0031974,GO:0033218,GO:0034641,GO:0035999,GO:0036094,GO:0042133,GO:0042135,GO:0042219,GO:0042402,GO:0042426,GO:0042558,GO:0043167,GO:0043168,GO:0043177,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0046483,GO:0046653,GO:0046997,GO:0048037,GO:0050660,GO:0050662,GO:0051186,GO:0055114,GO:0065007,GO:0065008,GO:0070013,GO:0071704,GO:0072341,GO:0097159,GO:0097164,GO:1901052,GO:1901053,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.5.3.19	ko:K19191	ko00760,ko01120,map00760,map01120	-	R10102	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO,FAO_M,GCV_T,GCV_T_C
k59_1084937_1	1415779.JOMH01000001_gene2885	7.64e-41	151.0	COG1115@1|root,COG1115@2|Bacteria,1MUI3@1224|Proteobacteria,1RMNF@1236|Gammaproteobacteria,1X57M@135614|Xanthomonadales	135614|Xanthomonadales	E	Sodium alanine symporter	-	-	-	ko:K03310	-	-	-	-	ko00000	2.A.25	-	-	Na_Ala_symp
k59_1585173_1	1185876.BN8_04332	1.22e-39	149.0	COG2866@1|root,COG2866@2|Bacteria,4NF3D@976|Bacteroidetes,47UEQ@768503|Cytophagia	976|Bacteroidetes	E	Zinc carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
k59_1253234_1	1380391.JIAS01000016_gene431	6.27e-43	154.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TQJR@28211|Alphaproteobacteria,2JQA5@204441|Rhodospirillales	204441|Rhodospirillales	I	COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases	-	-	6.2.1.17	ko:K01908	ko00640,ko01100,map00640,map01100	-	R00926,R01354	RC00004,RC00043,RC00070,RC02816	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_1253234_2	314278.NB231_11479	6.68e-22	92.4	COG2513@1|root,COG2513@2|Bacteria,1N4VT@1224|Proteobacteria,1RMR5@1236|Gammaproteobacteria,1WWC7@135613|Chromatiales	135613|Chromatiales	G	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate	prpB	-	4.1.3.30	ko:K03417	ko00640,map00640	-	R00409	RC00286,RC00287	ko00000,ko00001,ko01000	-	-	-	PEP_mutase
k59_28492_1	983544.Lacal_2910	7.4e-70	220.0	COG2801@1|root,COG2801@2|Bacteria,4NM64@976|Bacteroidetes,1HZ28@117743|Flavobacteriia	976|Bacteroidetes	L	COG2801 Transposase and inactivated derivatives	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	rve,rve_3
k59_1418070_2	1449353.JQMQ01000005_gene1103	6.39e-08	53.9	COG1109@1|root,COG1109@2|Bacteria,2GJQA@201174|Actinobacteria,2NGNK@228398|Streptacidiphilus	201174|Actinobacteria	G	Phosphoglucomutase/phosphomannomutase, C-terminal domain	manB	-	5.4.2.8	ko:K01840	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01818	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_28497_2	1121396.KB893066_gene1578	1.16e-05	52.8	COG1538@1|root,COG1538@2|Bacteria,1R8XP@1224|Proteobacteria,42QGI@68525|delta/epsilon subdivisions,2WJH9@28221|Deltaproteobacteria,2MJD1@213118|Desulfobacterales	28221|Deltaproteobacteria	MU	PFAM Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_1697048_1	1229780.BN381_330001	3.37e-15	82.0	COG1404@1|root,COG4932@1|root,COG1404@2|Bacteria,COG4932@2|Bacteria,2IFXI@201174|Actinobacteria	201174|Actinobacteria	M	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
k59_195017_1	926569.ANT_11650	8.95e-07	52.0	COG1239@1|root,COG1239@2|Bacteria,2G832@200795|Chloroflexi	200795|Chloroflexi	H	SMART AAA ATPase	-	-	6.6.1.1	ko:K03405	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	-	Mg_chelatase
k59_195017_2	479434.Sthe_0091	1.7e-17	78.6	COG1607@1|root,COG1607@2|Bacteria,2G7A6@200795|Chloroflexi	200795|Chloroflexi	I	PFAM thioesterase superfamily protein	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
k59_1362934_1	1089548.KI783301_gene1658	1.21e-16	74.7	COG1278@1|root,COG1278@2|Bacteria,1VEE0@1239|Firmicutes,4HNJC@91061|Bacilli,3WF21@539002|Bacillales incertae sedis	91061|Bacilli	K	'Cold-shock' DNA-binding domain	cspB	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
k59_1141102_1	1120983.KB894571_gene2655	8.32e-50	176.0	COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,2TQV8@28211|Alphaproteobacteria,1JNPY@119043|Rhodobiaceae	28211|Alphaproteobacteria	J	B3/4 domain	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
k59_1084971_1	383372.Rcas_1471	1.03e-34	122.0	COG2963@1|root,COG2963@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	ko:K07483,ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,HTH_Tnp_1,rve
k59_1084971_2	716544.wcw_1897	3.7e-16	79.7	COG2801@1|root,COG2801@2|Bacteria,2JHEV@204428|Chlamydiae	204428|Chlamydiae	L	Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve
k59_1196066_1	926569.ANT_22890	8.11e-17	81.6	COG1847@1|root,COG1847@2|Bacteria,2G6XH@200795|Chloroflexi	200795|Chloroflexi	S	PFAM single-stranded nucleic acid binding R3H domain protein	-	-	-	ko:K06346	-	-	-	-	ko00000	-	-	-	Jag_N,KH_4,R3H
k59_306943_1	519989.ECTPHS_03267	1.12e-61	201.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RP0W@1236|Gammaproteobacteria,1WWIR@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor	bioA	-	2.6.1.62	ko:K00833	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03231	RC00006,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_1362952_1	1122132.AQYH01000005_gene629	4.3e-35	129.0	COG1934@1|root,COG1934@2|Bacteria,1MXGA@1224|Proteobacteria	1224|Proteobacteria	S	Protein conserved in bacteria	lptA	-	-	ko:K09774	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA
k59_1253280_1	671143.DAMO_2251	2.27e-120	355.0	COG1158@1|root,COG1158@2|Bacteria,2NNXC@2323|unclassified Bacteria	2|Bacteria	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576	-	ko:K02887,ko:K03628	ko03010,ko03018,map03010,map03018	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
k59_806830_1	643562.Daes_2897	6.88e-05	50.8	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,42PQZ@68525|delta/epsilon subdivisions,2WMD9@28221|Deltaproteobacteria,2M8AQ@213115|Desulfovibrionales	28221|Deltaproteobacteria	Q	Hemolysin-type calcium-binding region	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin_3,FecR,HCBP_related,He_PIG,HemolysinCabind,Peptidase_M91,VWA,VWA_2
k59_1141124_1	215803.DB30_7235	2.78e-45	169.0	COG0577@1|root,COG0577@2|Bacteria,1NREW@1224|Proteobacteria,433ZM@68525|delta/epsilon subdivisions,2X48T@28221|Deltaproteobacteria,2YYI5@29|Myxococcales	1224|Proteobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_639018_1	682795.AciX8_2887	1.19e-57	196.0	COG0843@1|root,COG0843@2|Bacteria,3Y37Z@57723|Acidobacteria,2JIKT@204432|Acidobacteriia	204432|Acidobacteriia	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_474819_1	521096.Tpau_3053	6.04e-50	177.0	COG2303@1|root,COG2303@2|Bacteria,2GJKS@201174|Actinobacteria	201174|Actinobacteria	E	Oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N,Gluconate_2-dh3
k59_528844_1	1434325.AZQN01000003_gene1992	2.46e-22	102.0	COG0793@1|root,COG0793@2|Bacteria,4NEGV@976|Bacteroidetes,47JP7@768503|Cytophagia	976|Bacteroidetes	M	Belongs to the peptidase S41A family	ctp	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
k59_751129_2	1158292.JPOE01000005_gene68	1.52e-12	69.7	COG0643@1|root,COG0745@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0745@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,2VJSZ@28216|Betaproteobacteria,1KJ24@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Signal transducing histidine kinase, homodimeric domain	pilL	-	-	ko:K02487,ko:K06596	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg
k59_1585246_1	1121434.AULY01000014_gene2727	2.59e-12	68.2	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,42N74@68525|delta/epsilon subdivisions,2WKUN@28221|Deltaproteobacteria,2M9XK@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035,ko:K15584	ko02010,ko02024,map02010,map02024	M00239,M00440	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_1585246_2	264198.Reut_A1240	1.13e-10	62.8	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2VHCV@28216|Betaproteobacteria,1K2C1@119060|Burkholderiaceae	28216|Betaproteobacteria	E	transporter	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_306977_2	1121448.DGI_2874	7.38e-08	55.1	COG0266@1|root,COG0266@2|Bacteria,1MVM5@1224|Proteobacteria,42R8W@68525|delta/epsilon subdivisions,2WMZU@28221|Deltaproteobacteria,2M8M3@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
k59_1418137_1	247633.GP2143_13056	5.51e-13	73.9	28NHI@1|root,2ZBJA@2|Bacteria,1RCPZ@1224|Proteobacteria,1ST6N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1141155_1	215803.DB30_6745	2.99e-12	73.9	COG2234@1|root,COG2234@2|Bacteria,1MV86@1224|Proteobacteria,43E81@68525|delta/epsilon subdivisions,2WZZ4@28221|Deltaproteobacteria,2YU4S@29|Myxococcales	28221|Deltaproteobacteria	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
k59_861109_1	335543.Sfum_1624	3.61e-24	107.0	COG0823@1|root,COG0823@2|Bacteria,1PFBB@1224|Proteobacteria,432XJ@68525|delta/epsilon subdivisions,2WXKI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_474854_1	485913.Krac_12092	5.39e-90	279.0	COG4799@1|root,COG4799@2|Bacteria,2G5IX@200795|Chloroflexi	200795|Chloroflexi	I	PFAM carboxyl transferase	-	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_417697_2	292415.Tbd_0176	5.21e-66	216.0	COG0403@1|root,COG0403@2|Bacteria,1MVC1@1224|Proteobacteria,2VKQB@28216|Betaproteobacteria	28216|Betaproteobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
k59_1141179_1	100226.SCO3928	1.19e-20	95.9	COG0422@1|root,COG0422@2|Bacteria,2GJ3Y@201174|Actinobacteria	201174|Actinobacteria	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016020,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0040007,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC-associated,ThiC_Rad_SAM
k59_195111_1	1239962.C943_03718	3.63e-22	95.5	COG0500@1|root,COG2226@2|Bacteria,4NM9E@976|Bacteroidetes,47PMX@768503|Cytophagia	976|Bacteroidetes	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,Methyltransf_31
k59_141059_1	1242864.D187_003494	2.15e-10	58.5	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,42M98@68525|delta/epsilon subdivisions,2WMKB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM Integrase catalytic	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,HTH_Tnp_1,rve,rve_3
k59_141059_2	323848.Nmul_A1431	7.02e-22	89.0	COG2963@1|root,COG2963@2|Bacteria,1N28U@1224|Proteobacteria,2WEWH@28216|Betaproteobacteria,374NT@32003|Nitrosomonadales	1224|Proteobacteria	L	Helix-turn-helix domain	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_477304_1	864702.OsccyDRAFT_3400	1.14e-50	172.0	COG1801@1|root,COG1801@2|Bacteria,1G2CT@1117|Cyanobacteria,1H914@1150|Oscillatoriales	1117|Cyanobacteria	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
k59_1420337_1	196490.AUEZ01000054_gene287	3.12e-15	70.9	COG2151@1|root,COG2151@2|Bacteria,1NFJY@1224|Proteobacteria,2UYIV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Iron-sulfur cluster assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
k59_1420337_2	795666.MW7_1775	2.32e-37	135.0	COG3396@1|root,COG3396@2|Bacteria,1MVQ7@1224|Proteobacteria,2VHQZ@28216|Betaproteobacteria,1KAV1@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Phenylacetic acid catabolic protein	paaA	-	1.14.13.149	ko:K02609	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001,ko01000	-	-	-	PaaA_PaaC
k59_922345_1	1390370.O203_03285	3.32e-78	244.0	COG0686@1|root,COG0686@2|Bacteria,1QTX1@1224|Proteobacteria,1T1JB@1236|Gammaproteobacteria,1YHJ7@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	E	Alanine dehydrogenase/PNT, C-terminal domain	ald	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
k59_141078_1	246200.SPO3650	7.35e-15	79.7	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4NBBC@97050|Ruegeria	28211|Alphaproteobacteria	T	Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,TPR_16
k59_419783_1	469383.Cwoe_5915	1.08e-44	160.0	COG0104@1|root,COG0104@2|Bacteria,2GMP4@201174|Actinobacteria,4CPAP@84995|Rubrobacteria	84995|Rubrobacteria	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
k59_809093_1	234267.Acid_7680	2e-64	220.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
k59_863224_1	930169.B5T_04161	1.47e-24	102.0	COG0491@1|root,COG0491@2|Bacteria,1MUDN@1224|Proteobacteria,1RMMG@1236|Gammaproteobacteria,1XHKZ@135619|Oceanospirillales	135619|Oceanospirillales	S	COG0491 Zn-dependent hydrolases, including glyoxylases	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_1087368_1	55529.EKX39363	5.61e-41	148.0	COG3146@1|root,2QRI5@2759|Eukaryota	2759|Eukaryota	S	Peptidogalycan biosysnthesis/recognition	-	-	-	ko:K09919	-	-	-	-	ko00000	-	-	-	FemAB_like
k59_753129_1	861299.J421_0065	1.93e-43	160.0	COG2120@1|root,COG2120@2|Bacteria,1ZT6U@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
k59_477348_1	477641.MODMU_2959	3.88e-71	236.0	COG3119@1|root,COG3119@2|Bacteria,2GJ8H@201174|Actinobacteria	201174|Actinobacteria	P	Pfam Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_1531313_2	312153.Pnuc_0788	1.87e-19	83.6	COG2391@1|root,COG2391@2|Bacteria,1N3PQ@1224|Proteobacteria,2VXAQ@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Sulphur transport	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
k59_1198165_1	1340434.AXVA01000003_gene1529	2.19e-18	86.3	COG0567@1|root,COG0567@2|Bacteria,1TRDW@1239|Firmicutes,4HAUI@91061|Bacilli,1ZAX3@1386|Bacillus	91061|Bacilli	C	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3)	odhA	GO:0003674,GO:0003824,GO:0004591,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016624,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045333,GO:0055114,GO:0071704,GO:0072350,GO:1902494,GO:1990204,GO:1990234	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
k59_1198165_2	1123252.ATZF01000002_gene2404	3.19e-19	88.6	COG0508@1|root,COG0508@2|Bacteria,1TP3C@1239|Firmicutes,4HBVM@91061|Bacilli,27CNF@186824|Thermoactinomycetaceae	91061|Bacilli	C	Biotin-lipoyl like	odhB	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_30558_1	251229.Chro_2730	1.65e-60	199.0	COG1503@1|root,COG1503@2|Bacteria,1G29A@1117|Cyanobacteria,3VMJ4@52604|Pleurocapsales	1117|Cyanobacteria	J	translation release factor activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_530989_1	97139.C824_03106	1.85e-31	122.0	COG1209@1|root,COG1209@2|Bacteria,1TPR2@1239|Firmicutes,2490F@186801|Clostridia,36FMD@31979|Clostridiaceae	186801|Clostridia	M	Nucleotidyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transferase
k59_753156_1	326427.Cagg_0668	4.15e-16	82.8	COG5184@1|root,COG5184@2|Bacteria,2G8WU@200795|Chloroflexi,3765G@32061|Chloroflexia	200795|Chloroflexi	DZ	PFAM regulator of chromosome condensation, RCC1	-	-	-	-	-	-	-	-	-	-	-	-	RCC1,RCC1_2
k59_1476687_1	1265310.CCBD010000070_gene123	5.89e-24	105.0	COG2114@1|root,COG2197@1|root,COG3903@1|root,COG2114@2|Bacteria,COG2197@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,233DM@1762|Mycobacteriaceae	201174|Actinobacteria	K	involved in signal transduction (via phosphorylation) involved in transcriptional regulatory mechanism and in the regulation of secondary metabolites catalytic activity ATP a protein ADP a phosphoprotein	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	GerE,Guanylate_cyc,NB-ARC
k59_1255542_1	313606.M23134_06826	1.26e-66	223.0	COG0591@1|root,COG0591@2|Bacteria,4PKHI@976|Bacteroidetes,47MV2@768503|Cytophagia	976|Bacteroidetes	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
k59_1476692_1	1226994.AMZB01000064_gene3847	3.18e-08	59.7	COG2084@1|root,COG2084@2|Bacteria,1RA7F@1224|Proteobacteria,1RMMY@1236|Gammaproteobacteria,1YF35@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	I	Belongs to the 3-hydroxyisobutyrate dehydrogenase family	mmsB	-	1.1.1.31,1.1.1.387	ko:K00020,ko:K19711	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
k59_1310368_1	880526.KE386488_gene814	7.48e-13	73.6	COG0845@1|root,COG0845@2|Bacteria,4NHJH@976|Bacteroidetes,2FP9C@200643|Bacteroidia,22U14@171550|Rikenellaceae	976|Bacteroidetes	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
k59_531015_1	1205680.CAKO01000002_gene2530	4.8e-103	320.0	COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,2TSZ9@28211|Alphaproteobacteria,2JQNV@204441|Rhodospirillales	204441|Rhodospirillales	C	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	-	-	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_N
k59_863283_1	1304883.KI912532_gene1266	1e-13	70.5	COG2607@1|root,COG2607@2|Bacteria,1MVMX@1224|Proteobacteria,2VID5@28216|Betaproteobacteria,2KUQI@206389|Rhodocyclales	206389|Rhodocyclales	S	ATPase (AAA	-	-	-	ko:K06923	-	-	-	-	ko00000	-	-	-	DUF815
k59_863283_2	864051.BurJ1DRAFT_1243	6.59e-57	189.0	COG1364@1|root,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,2VJ84@28216|Betaproteobacteria,1KJ4N@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	-	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
k59_252573_2	1502851.FG93_00428	1.17e-39	142.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TR15@28211|Alphaproteobacteria,3JR8X@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_1420425_2	391589.RGAI101_108	2.48e-17	79.3	COG0583@1|root,COG0583@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	ko:K13928	-	-	-	-	ko00000,ko03000	-	-	-	LysR_substrate
k59_1699722_1	926569.ANT_29800	9.34e-84	261.0	COG0621@1|root,COG0621@2|Bacteria,2G5QK@200795|Chloroflexi	200795|Chloroflexi	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
k59_1365319_1	1146883.BLASA_4799	6.88e-23	103.0	COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria,4ERST@85013|Frankiales	201174|Actinobacteria	C	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_1531360_1	268407.PWYN_10105	1.66e-53	181.0	COG0626@1|root,COG0626@2|Bacteria,1TPC7@1239|Firmicutes,4HCAV@91061|Bacilli,26T6S@186822|Paenibacillaceae	91061|Bacilli	E	cystathionine	mgl	-	4.4.1.11	ko:K01761	ko00270,ko00450,map00270,map00450	-	R00654,R04770	RC00196,RC00348,RC01209,RC01210	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
k59_1420438_1	1379698.RBG1_1C00001G1252	8.83e-24	101.0	COG0836@1|root,COG0836@2|Bacteria,2NP3C@2323|unclassified Bacteria	2|Bacteria	M	Mannose-6-phosphate isomerase	manC	-	2.7.7.13,5.3.1.8,5.4.2.8	ko:K00971,ko:K01840,ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00361,M00362	R00885,R01818,R01819	RC00002,RC00376,RC00408	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS00940	MannoseP_isomer,NTP_transferase
k59_930481_2	1123368.AUIS01000024_gene947	2.37e-65	210.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria,2NDPN@225057|Acidithiobacillales	225057|Acidithiobacillales	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1373128_1	469616.FMAG_02262	5.66e-06	49.3	COG0165@1|root,COG0165@2|Bacteria,378W4@32066|Fusobacteria	32066|Fusobacteria	E	Psort location Cytoplasmic, score	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
k59_37404_1	1005999.GLGR_2227	1.55e-40	149.0	COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,1RMWU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation	surA	GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006457,GO:0006458,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0022607,GO:0030288,GO:0030313,GO:0031647,GO:0031975,GO:0033218,GO:0036211,GO:0042277,GO:0042597,GO:0043163,GO:0043165,GO:0043170,GO:0043412,GO:0044085,GO:0044091,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0044764,GO:0045229,GO:0050821,GO:0051082,GO:0051084,GO:0051085,GO:0051704,GO:0060274,GO:0061024,GO:0061077,GO:0065007,GO:0065008,GO:0071704,GO:0071709,GO:0071840,GO:0140096,GO:1901564	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_3,SurA_N
k59_427184_1	1229780.BN381_130373	1.45e-19	92.0	COG2159@1|root,COG2159@2|Bacteria,2GP2D@201174|Actinobacteria	201174|Actinobacteria	S	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
k59_37435_1	981383.AEWH01000046_gene1359	6.97e-57	182.0	COG0605@1|root,COG0605@2|Bacteria,1TPXT@1239|Firmicutes,4HA6U@91061|Bacilli	91061|Bacilli	C	radicals which are normally produced within the cells and which are toxic to biological systems	sodA	GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004784,GO:0006801,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016721,GO:0019430,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0044237,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071450,GO:0071451,GO:0072593,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1901701,GO:1990748	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
k59_371550_1	861299.J421_3941	9.52e-47	163.0	COG0624@1|root,COG0624@2|Bacteria,1ZTIX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
k59_371557_2	1266908.AQPB01000035_gene152	5.3e-30	110.0	COG0859@1|root,COG0859@2|Bacteria,1MZGQ@1224|Proteobacteria,1S7TT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	PFAM glycosyl transferase family 9	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1205548_1	156889.Mmc1_1098	4.28e-58	201.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2TR24@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG1042 Acyl-CoA synthetase (NDP forming)	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
k59_930559_1	926550.CLDAP_27060	2.29e-51	184.0	COG0366@1|root,COG4733@1|root,COG0366@2|Bacteria,COG4733@2|Bacteria,2G7WY@200795|Chloroflexi	200795|Chloroflexi	G	Belongs to the glycosyl hydrolase 13 family	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,CBM_20,fn3
k59_1151009_1	1313172.YM304_18320	4.65e-94	286.0	COG1219@1|root,COG1219@2|Bacteria,2GJXQ@201174|Actinobacteria,4CMS8@84992|Acidimicrobiia	84992|Acidimicrobiia	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
k59_427207_1	1123276.KB893246_gene854	6.15e-78	251.0	COG3385@1|root,COG3385@2|Bacteria,4P02Y@976|Bacteroidetes,47TUA@768503|Cytophagia	976|Bacteroidetes	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_93595_1	991905.SL003B_3565	3.61e-57	195.0	COG2114@1|root,COG2770@1|root,COG2114@2|Bacteria,COG2770@2|Bacteria,1QVNT@1224|Proteobacteria,2TWID@28211|Alphaproteobacteria,4BREA@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,HAMP
k59_816446_1	646529.Desaci_0041	5.15e-51	176.0	COG3547@1|root,COG3547@2|Bacteria,1V427@1239|Firmicutes,24E1F@186801|Clostridia	186801|Clostridia	L	transposase IS116 IS110 IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1263587_1	357808.RoseRS_0444	1.74e-72	237.0	COG3385@1|root,COG3385@2|Bacteria,2G9A6@200795|Chloroflexi	200795|Chloroflexi	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_760688_1	176299.Atu1105	3.38e-18	87.8	COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,2TSJ3@28211|Alphaproteobacteria,4B9SQ@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	Parvulin-like peptidyl-prolyl isomerase	surA	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,SurA_N,SurA_N_3
k59_816460_1	1244869.H261_07723	2.19e-46	161.0	COG1466@1|root,COG1466@2|Bacteria,1R8PA@1224|Proteobacteria,2U1KQ@28211|Alphaproteobacteria,2JQE9@204441|Rhodospirillales	204441|Rhodospirillales	L	DNA polymerase III, delta subunit	holA	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
k59_985071_1	1121930.AQXG01000001_gene1102	3.07e-61	211.0	COG2091@1|root,COG2091@2|Bacteria,4NGXG@976|Bacteroidetes	976|Bacteroidetes	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
k59_1538529_2	448385.sce5009	4.04e-06	48.9	COG1225@1|root,COG1225@2|Bacteria,1RH4P@1224|Proteobacteria,431EI@68525|delta/epsilon subdivisions,2WWHD@28221|Deltaproteobacteria,2Z0G4@29|Myxococcales	28221|Deltaproteobacteria	O	Redoxin	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
k59_1538529_3	1122985.HMPREF1991_02351	8.28e-05	45.1	COG0526@1|root,COG0526@2|Bacteria,4NEX3@976|Bacteroidetes,2FN8N@200643|Bacteroidia	976|Bacteroidetes	CO	AhpC Tsa family	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,DUF4369,Thioredoxin_8
k59_259574_2	1122619.KB892322_gene8	2.71e-31	127.0	COG4372@1|root,COG4372@2|Bacteria,1MUCX@1224|Proteobacteria,2WGN9@28216|Betaproteobacteria,3T3JA@506|Alcaligenaceae	28216|Betaproteobacteria	S	Transposase IS66 family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
k59_816479_1	1121364.ATVG01000006_gene608	2.87e-08	54.3	COG0152@1|root,COG0152@2|Bacteria,2GK3H@201174|Actinobacteria,22KFW@1653|Corynebacteriaceae	201174|Actinobacteria	F	Belongs to the SAICAR synthetase family	purC	GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.6,6.3.4.13	ko:K01923,ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144,R04591	RC00064,RC00090,RC00162,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
k59_816479_2	997346.HMPREF9374_3072	1.44e-14	69.3	COG1828@1|root,COG1828@2|Bacteria,1VEH1@1239|Firmicutes,4HP0E@91061|Bacilli,27CAM@186824|Thermoactinomycetaceae	91061|Bacilli	F	Phosphoribosylformylglycinamidine (FGAM) synthase	purS	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU06460	PurS
k59_816479_3	518766.Rmar_2306	4.9e-37	132.0	COG0047@1|root,COG0047@2|Bacteria,4NFER@976|Bacteroidetes,1FIWZ@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
k59_1095062_1	1380394.JADL01000005_gene5357	7.98e-45	150.0	COG1607@1|root,COG1607@2|Bacteria,1MZAZ@1224|Proteobacteria,2U93J@28211|Alphaproteobacteria,2JSPZ@204441|Rhodospirillales	204441|Rhodospirillales	I	Thioesterase superfamily	-	-	-	ko:K10806	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	4HBT
k59_816484_2	882082.SaccyDRAFT_0921	9.88e-32	126.0	COG0068@1|root,COG0068@2|Bacteria,2GJYF@201174|Actinobacteria,4DYVA@85010|Pseudonocardiales	201174|Actinobacteria	O	Belongs to the carbamoyltransferase HypF family	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
k59_1263636_1	62928.azo1341	4.47e-08	54.3	COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,2VIWB@28216|Betaproteobacteria,2KVB2@206389|Rhodocyclales	206389|Rhodocyclales	C	Belongs to the heme-copper respiratory oxidase family	-	-	1.9.3.1	ko:K00404	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	COX1
k59_1263636_2	1265502.KB905930_gene1468	1.72e-112	327.0	COG2993@1|root,COG2993@2|Bacteria,1MXEY@1224|Proteobacteria,2VIJ2@28216|Betaproteobacteria,4ABQK@80864|Comamonadaceae	28216|Betaproteobacteria	C	cytochrome c oxidase, cbb3-type, subunit II	ccoO	-	-	ko:K00405	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	FixO
k59_1595564_1	1394178.AWOO02000002_gene1764	3.69e-25	107.0	COG0673@1|root,COG0673@2|Bacteria,2HF6B@201174|Actinobacteria,4EQHQ@85012|Streptosporangiales	201174|Actinobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
k59_1095083_1	1121468.AUBR01000008_gene2048	1.63e-31	115.0	COG5496@1|root,COG5496@2|Bacteria,1VAZJ@1239|Firmicutes,24MWR@186801|Clostridia,42GZU@68295|Thermoanaerobacterales	186801|Clostridia	S	THIoesterase	-	-	3.1.2.29	ko:K18700	-	-	-	-	ko00000,ko01000	-	-	-	4HBT
k59_1095083_2	999141.GME_06385	7.16e-38	140.0	COG0642@1|root,COG2205@2|Bacteria,1MUAK@1224|Proteobacteria,1RPP2@1236|Gammaproteobacteria,1XJ2S@135619|Oceanospirillales	135619|Oceanospirillales	T	Histidine kinase	envZ	-	2.7.13.3	ko:K07638	ko02020,ko02026,map02020,map02026	M00445,M00742,M00743	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
k59_1041417_1	671143.DAMO_2251	1.51e-91	280.0	COG1158@1|root,COG1158@2|Bacteria,2NNXC@2323|unclassified Bacteria	2|Bacteria	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576	-	ko:K02887,ko:K03628	ko03010,ko03018,map03010,map03018	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
k59_1041417_2	572547.Amico_0722	3.36e-16	71.6	COG0254@1|root,COG0254@2|Bacteria,3TBCE@508458|Synergistetes	508458|Synergistetes	J	Binds the 23S rRNA	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
k59_429288_1	1049564.TevJSym_bb00050	9.77e-95	297.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,1S0WV@1236|Gammaproteobacteria,1J5KF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases	korA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
k59_1320597_1	685035.ADAE01000002_gene2518	2.91e-30	119.0	2CK9T@1|root,2Z7W9@2|Bacteria,1NEP3@1224|Proteobacteria,2U3MN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_95882_1	760568.Desku_2546	1.31e-93	287.0	COG0195@1|root,COG0195@2|Bacteria,1TPB3@1239|Firmicutes,247W8@186801|Clostridia,2604E@186807|Peptococcaceae	186801|Clostridia	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_5,NusA_N,S1
k59_1320599_1	1191523.MROS_0845	2.16e-78	246.0	COG0045@1|root,COG0045@2|Bacteria	2|Bacteria	C	succinate-CoA ligase activity	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
k59_1153082_1	879212.DespoDRAFT_03382	1.16e-07	58.5	COG0457@1|root,COG2304@1|root,COG0457@2|Bacteria,COG2304@2|Bacteria,1MW51@1224|Proteobacteria,42M45@68525|delta/epsilon subdivisions,2WM19@28221|Deltaproteobacteria,2MHT6@213118|Desulfobacterales	28221|Deltaproteobacteria	K	PFAM von Willebrand factor type A domain	batB	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	BatA,TPR_1,TPR_16,TPR_2,VWA,VWA_2
k59_818644_1	66874.JOFS01000022_gene5734	0.000597	47.4	COG0738@1|root,COG0738@2|Bacteria,2HF27@201174|Actinobacteria	201174|Actinobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1540467_1	1123239.KB898644_gene21	1.78e-08	58.5	COG1484@1|root,COG1484@2|Bacteria,1TRNX@1239|Firmicutes,4HAQR@91061|Bacilli	91061|Bacilli	L	DNA replication protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
k59_319692_1	640081.Dsui_2669	1.09e-23	100.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	-	-	-	ko:K06867	-	-	-	-	ko00000	-	-	-	Ank_2,Ank_4,Ank_5,DUF4274
k59_1650672_1	671143.DAMO_1639	1.39e-96	289.0	COG1355@1|root,COG1355@2|Bacteria,2NQ00@2323|unclassified Bacteria	2|Bacteria	S	Evidence 4 Homologs of previously reported genes of	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0032886,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0065007	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
k59_1540471_1	502025.Hoch_3985	1.35e-45	160.0	COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,42MGM@68525|delta/epsilon subdivisions,2WIZ7@28221|Deltaproteobacteria,2YU46@29|Myxococcales	28221|Deltaproteobacteria	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
k59_1540471_2	1205680.CAKO01000004_gene3587	4.72e-11	62.0	COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,2TT6A@28211|Alphaproteobacteria,2JPCK@204441|Rhodospirillales	204441|Rhodospirillales	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
k59_1597708_1	1379270.AUXF01000004_gene3061	6.59e-55	182.0	COG1842@1|root,COG1842@2|Bacteria,1ZT82@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KT	PspA/IM30 family	-	-	-	ko:K03969	-	-	-	-	ko00000	-	-	-	PspA_IM30
k59_261591_2	1123514.KB905899_gene672	4.1e-14	75.9	COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,1RMUH@1236|Gammaproteobacteria,45ZUB@72273|Thiotrichales	72273|Thiotrichales	C	NADH-quinone oxidoreductase	nuoG	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_1153099_1	1500897.JQNA01000002_gene1106	7.47e-14	76.3	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2VHB9@28216|Betaproteobacteria,1K3BZ@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C2
k59_1710058_1	557599.MKAN_17235	9.34e-96	285.0	COG2039@1|root,COG2039@2|Bacteria,2GN39@201174|Actinobacteria,235KE@1762|Mycobacteriaceae	201174|Actinobacteria	J	Removes 5-oxoproline from various penultimate amino acid residues except L-proline	pcp	GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0019538,GO:0043170,GO:0044238,GO:0071704,GO:1901564	3.4.19.3	ko:K01304	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_C15
k59_1540491_1	1122132.AQYH01000005_gene522	1.75e-98	296.0	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,2TRZ1@28211|Alphaproteobacteria,4B9J9@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
k59_487138_1	861299.J421_2550	8.09e-49	167.0	COG0266@1|root,COG0266@2|Bacteria,1ZUR3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Formamidopyrimidine-DNA glycosylase N-terminal domain	-	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
k59_1486679_1	1128421.JAGA01000002_gene1382	2.62e-17	77.4	COG2905@1|root,COG2905@2|Bacteria	2|Bacteria	T	signal-transduction protein containing cAMP-binding and CBS domains	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_1486679_2	457570.Nther_1946	5.63e-28	112.0	COG0154@1|root,COG0154@2|Bacteria,1TP0C@1239|Firmicutes,24911@186801|Clostridia	186801|Clostridia	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
k59_319727_1	402881.Plav_1470	2.53e-60	191.0	COG1051@1|root,COG1051@2|Bacteria,1QU0T@1224|Proteobacteria,2TW25@28211|Alphaproteobacteria,1JQNM@119043|Rhodobiaceae	28211|Alphaproteobacteria	F	NUDIX domain	nudH	-	-	ko:K08311	ko03018,map03018	-	R10816	RC00002	ko00000,ko00001,ko01000,ko03019	-	-	-	NUDIX
k59_1320652_1	1123500.ATUU01000004_gene1120	6.74e-09	59.3	COG0577@1|root,COG1136@1|root,COG0577@2|Bacteria,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,4HBK7@91061|Bacilli,4AX02@81850|Leuconostocaceae	91061|Bacilli	V	ABC-type antimicrobial peptide transport system, ATPase component	yhcA	-	-	ko:K02003,ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,FtsX,MacB_PCD
k59_205647_1	926569.ANT_15860	6.42e-68	233.0	COG1807@1|root,COG5427@1|root,COG1807@2|Bacteria,COG5427@2|Bacteria,2G5UJ@200795|Chloroflexi	200795|Chloroflexi	M	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2298,PMT_2,TPR_16,TPR_19,TPR_8
k59_95936_1	316274.Haur_0044	9.94e-15	79.0	COG0457@1|root,COG2114@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,2G699@200795|Chloroflexi,3764S@32061|Chloroflexia	32061|Chloroflexia	T	PFAM adenylyl cyclase class-3 4 guanylyl cyclase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Guanylate_cyc,TPR_12,TPR_2
k59_39545_1	1187851.A33M_2950	8.92e-41	149.0	COG0654@1|root,COG0654@2|Bacteria,1MWWT@1224|Proteobacteria,2TRZP@28211|Alphaproteobacteria,3FDPR@34008|Rhodovulum	28211|Alphaproteobacteria	CH	FAD binding domain	nah	-	1.14.13.1	ko:K00480	ko00621,ko00624,ko00626,ko01100,ko01120,ko01220,map00621,map00624,map00626,map01100,map01120,map01220	-	R00818,R05632,R06915,R06936,R06939	RC00389	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3
k59_873655_1	1304275.C41B8_00175	7.43e-105	311.0	COG2132@1|root,COG2132@2|Bacteria,1QUX3@1224|Proteobacteria,1S6MG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	Domain of unknown function (DUF4396)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4396
k59_95943_1	859657.RPSI07_1540	7.3e-58	190.0	COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,2VHZ4@28216|Betaproteobacteria,1K1RM@119060|Burkholderiaceae	28216|Betaproteobacteria	S	alcohol dehydrogenase	-	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N
k59_1710086_1	1265505.ATUG01000002_gene2462	3.03e-31	119.0	COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria,42NXB@68525|delta/epsilon subdivisions,2WMBF@28221|Deltaproteobacteria,2MPC0@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Membrane dipeptidase (Peptidase family M19)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M19
k59_1540518_1	1121104.AQXH01000001_gene1151	4e-42	150.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_39555_1	357808.RoseRS_3781	3.25e-38	143.0	COG0770@1|root,COG0770@2|Bacteria,2G5PN@200795|Chloroflexi,374X6@32061|Chloroflexia	32061|Chloroflexia	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_1375455_1	269796.Rru_A0009	2.94e-33	119.0	COG1762@1|root,COG1762@2|Bacteria,1RD0E@1224|Proteobacteria,2U7B0@28211|Alphaproteobacteria,2JS6Q@204441|Rhodospirillales	204441|Rhodospirillales	GT	COG1762 Phosphotransferase system mannitol fructose-specific IIA domain (Ntr-type)	ptsN	-	-	ko:K02806	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	PTS_EIIA_2
k59_1375455_2	864069.MicloDRAFT_00016260	1.85e-25	104.0	COG0739@1|root,COG0739@2|Bacteria,1PVZJ@1224|Proteobacteria,2TRAB@28211|Alphaproteobacteria,1JXVY@119045|Methylobacteriaceae	28211|Alphaproteobacteria	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_95949_1	861299.J421_1386	8.92e-41	149.0	COG1473@1|root,COG1473@2|Bacteria,1ZUAX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer
k59_319750_1	1173020.Cha6605_3406	1.15e-33	124.0	COG1234@1|root,COG1234@2|Bacteria,1G1SW@1117|Cyanobacteria	1117|Cyanobacteria	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_4,HTH_Tnp_4
k59_429364_2	1435356.Y013_03670	3.66e-10	62.0	COG0596@1|root,COG2114@1|root,COG0596@2|Bacteria,COG2114@2|Bacteria,2IASU@201174|Actinobacteria,4FUZX@85025|Nocardiaceae	201174|Actinobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	lipJ	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Guanylate_cyc
k59_319758_1	1463857.JOFZ01000001_gene5505	7.96e-20	85.9	COG0315@1|root,COG0315@2|Bacteria,2IHR6@201174|Actinobacteria	201174|Actinobacteria	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
k59_319758_2	1223542.GM1_003_02860	1.54e-17	84.3	COG0303@1|root,COG0303@2|Bacteria,2GJC3@201174|Actinobacteria,4GAIV@85026|Gordoniaceae	201174|Actinobacteria	H	MoeA C-terminal region (domain IV)	moeA	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
k59_150894_1	3885.XP_007137605.1	9.01e-32	129.0	COG0661@1|root,KOG1235@2759|Eukaryota,37PWH@33090|Viridiplantae,3G9ZN@35493|Streptophyta,4JJCU@91835|fabids	35493|Streptophyta	S	aarF domain-containing protein kinase At1g79600	-	-	-	-	-	-	-	-	-	-	-	-	ABC1
k59_319767_1	926569.ANT_13960	8.55e-15	76.3	COG1574@1|root,COG1574@2|Bacteria,2G5YJ@200795|Chloroflexi	200795|Chloroflexi	S	PFAM Amidohydrolase 3	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_114526_1	309801.trd_A0087	3.58e-08	53.9	COG1028@1|root,COG1028@2|Bacteria,2G8II@200795|Chloroflexi,27XKN@189775|Thermomicrobia	189775|Thermomicrobia	IQ	Dehydrogenase reductase sdr	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_448231_1	452637.Oter_3687	5.59e-41	152.0	COG0514@1|root,COG0514@2|Bacteria,46S7V@74201|Verrucomicrobia,3K7AV@414999|Opitutae	414999|Opitutae	L	ATP-dependent DNA helicase RecQ	-	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,Helicase_C,RQC,RecQ_Zn_bind
k59_1337641_1	1382306.JNIM01000001_gene1023	5.86e-90	288.0	COG1529@1|root,COG1529@2|Bacteria	2|Bacteria	C	xanthine dehydrogenase activity	hcrA	-	1.3.7.9	ko:K04108	ko00362,ko00627,ko01100,ko01120,ko01220,map00362,map00627,map01100,map01120,map01220	-	R05316	RC00490	ko00000,ko00001,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_1282074_2	1410658.JHWI01000004_gene192	1.64e-20	90.5	COG3394@1|root,COG3394@2|Bacteria,1V3MB@1239|Firmicutes,3VPTA@526524|Erysipelotrichia	526524|Erysipelotrichia	G	YdjC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YdjC
k59_559141_1	314345.SPV1_05467	1.11e-52	179.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria	1224|Proteobacteria	Q	COG1233 Phytoene dehydrogenase and related proteins	-	-	1.3.99.23,5.2.1.13	ko:K09516,ko:K09835	ko00830,ko00906,ko01100,ko01110,map00830,map00906,map01100,map01110	M00097	R07163,R07512	RC01835,RC01960	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase,NAD_binding_8
k59_559141_2	247633.GP2143_04133	1.43e-23	96.7	COG2020@1|root,COG2020@2|Bacteria,1R7G6@1224|Proteobacteria,1S9RT@1236|Gammaproteobacteria,1JAVK@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
k59_281401_1	1038860.AXAP01000033_gene4424	7.38e-14	77.0	COG0784@1|root,COG3850@1|root,COG4191@1|root,COG0784@2|Bacteria,COG3850@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,3JW72@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,MASE4,PAS_3,PAS_4,Response_reg,dCache_1
k59_281401_2	1415166.NONO_c67030	0.000463	42.7	COG2197@1|root,COG2197@2|Bacteria,2GJ9U@201174|Actinobacteria,4FX62@85025|Nocardiaceae	201174|Actinobacteria	T	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	-	-	-	ko:K07693	ko02020,map02020	M00479	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
k59_392562_1	317025.Tcr_0338	8.91e-92	282.0	COG1680@1|root,COG1680@2|Bacteria,1P3SQ@1224|Proteobacteria,1RRMI@1236|Gammaproteobacteria,462ZC@72273|Thiotrichales	72273|Thiotrichales	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_503794_1	1288298.rosmuc_03503	5.78e-51	175.0	COG0665@1|root,COG0665@2|Bacteria,1MVGP@1224|Proteobacteria,2TRX9@28211|Alphaproteobacteria,46QDK@74030|Roseovarius	28211|Alphaproteobacteria	E	COG0665 Glycine D-amino acid oxidases (deaminating)	ordL	-	-	ko:K09471	ko00330,ko01100,map00330,map01100	M00136	R07415	RC00062	ko00000,ko00001,ko00002,ko01000	-	-	-	DAO
k59_1726754_1	358220.C380_05850	5.57e-06	47.8	COG0477@1|root,COG2814@2|Bacteria,1R2KY@1224|Proteobacteria,2VI3X@28216|Betaproteobacteria,4AGHI@80864|Comamonadaceae	28216|Betaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1726754_2	290317.Cpha266_2123	1.72e-55	185.0	COG0730@1|root,COG0730@2|Bacteria	2|Bacteria	S	response to heat	yrkJ	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
k59_1559998_2	326427.Cagg_3170	2.42e-11	64.7	COG1232@1|root,COG1232@2|Bacteria,2G5VN@200795|Chloroflexi,375DN@32061|Chloroflexia	32061|Chloroflexia	H	PFAM amine oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
k59_1559998_3	926569.ANT_19090	2.7e-45	159.0	COG1232@1|root,COG1232@2|Bacteria,2G5VN@200795|Chloroflexi	200795|Chloroflexi	H	PFAM amine oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
k59_614880_1	84531.JMTZ01000039_gene548	0.000138	49.3	COG0739@1|root,COG0739@2|Bacteria,1R8E7@1224|Proteobacteria,1RZDF@1236|Gammaproteobacteria,1X9EG@135614|Xanthomonadales	135614|Xanthomonadales	M	BlaR1 peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23,Peptidase_M56
k59_614883_1	234267.Acid_3518	2.61e-45	169.0	COG2866@1|root,COG2866@2|Bacteria	2|Bacteria	E	metallocarboxypeptidase activity	-	-	-	ko:K14054	-	-	-	-	ko00000	-	-	-	AstE_AspA,Peptidase_M14
k59_1004181_1	1123242.JH636434_gene5621	2.7e-84	264.0	COG0702@1|root,COG0702@2|Bacteria,2IYQV@203682|Planctomycetes	203682|Planctomycetes	GM	PFAM NAD-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2867,NAD_binding_10
k59_614892_1	491916.RHECIAT_CH0000355	3.81e-35	128.0	COG1801@1|root,COG1801@2|Bacteria,1MU7F@1224|Proteobacteria,2TT1D@28211|Alphaproteobacteria,4B9NC@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
k59_614892_2	1243664.CAVL020000009_gene699	3.08e-05	46.6	COG1574@1|root,COG1574@2|Bacteria,1TQ6G@1239|Firmicutes,4H9T6@91061|Bacilli,1ZC1J@1386|Bacillus	91061|Bacilli	S	Amidohydrolase family	ytcJ	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_170194_1	1123371.ATXH01000007_gene564	1.4e-51	179.0	COG1190@1|root,COG1190@2|Bacteria,2GGTQ@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
k59_1726773_1	1121405.dsmv_2002	2.6e-74	245.0	COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,42NJD@68525|delta/epsilon subdivisions,2WJFK@28221|Deltaproteobacteria,2MHNT@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Belongs to the peptidase S16 family	-	-	3.4.21.53	ko:K04076	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AAA_32,Lon_C,Mg_chelatase
k59_1726773_2	481448.Minf_2021	2.32e-08	60.1	COG0589@1|root,COG0589@2|Bacteria,46YT6@74201|Verrucomicrobia,37GUT@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	T	response to stress	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_503833_1	644966.Tmar_0451	2.79e-18	89.0	COG0346@1|root,COG0400@1|root,COG0346@2|Bacteria,COG0400@2|Bacteria,1TQCN@1239|Firmicutes,24GX6@186801|Clostridia	186801|Clostridia	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K15975	-	-	-	-	ko00000	-	-	-	DLH,Glyoxalase
k59_1449027_1	1118054.CAGW01000017_gene4352	5.64e-33	127.0	COG1349@1|root,COG1349@2|Bacteria,1TSHY@1239|Firmicutes,4HD6Y@91061|Bacilli,26X99@186822|Paenibacillaceae	91061|Bacilli	GK	DeoR C terminal sensor domain	-	-	-	ko:K22103	-	-	-	-	ko00000,ko03000	-	-	-	DeoRC,HTH_DeoR
k59_726300_1	722419.PH505_aw00210	9.79e-81	248.0	COG0398@1|root,COG0398@2|Bacteria,1RBAE@1224|Proteobacteria,1S32X@1236|Gammaproteobacteria,2Q17J@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	S	Protein of unknown function, DUF547	-	-	-	-	-	-	-	-	-	-	-	-	DUF547
k59_1282140_1	621372.ACIH01000032_gene604	1.2e-59	194.0	COG1879@1|root,COG1879@2|Bacteria,1TQ1B@1239|Firmicutes,4HCSN@91061|Bacilli,26SYM@186822|Paenibacillaceae	91061|Bacilli	G	Periplasmic substrate-binding component of the ATP-dependent ribose transport system	rbsB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0015144,GO:0015145,GO:0015749,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0034219,GO:0044425,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944	-	ko:K10439,ko:K17202	ko02010,ko02030,map02010,map02030	M00212,M00590	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.11,3.A.1.2.13,3.A.1.2.16,3.A.1.2.19	-	-	Peripla_BP_4
k59_1615556_1	457415.HMPREF1006_02348	3.8e-14	76.3	COG1192@1|root,COG1192@2|Bacteria	2|Bacteria	D	plasmid maintenance	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31,CbiA,VirC1
k59_336833_1	3075.A0A087SFZ4	7.65e-17	78.6	COG0231@1|root,2QS68@2759|Eukaryota,37QV9@33090|Viridiplantae	33090|Viridiplantae	J	Elongation factor P	-	-	-	-	-	-	-	-	-	-	-	-	EFP,EFP_N,Elong-fact-P_C
k59_336833_2	1288826.MSNKSG1_12632	8.6e-33	121.0	COG1586@1|root,COG1586@2|Bacteria,1MXPT@1224|Proteobacteria,1RQSX@1236|Gammaproteobacteria,465SJ@72275|Alteromonadaceae	1236|Gammaproteobacteria	H	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine	speD	GO:0003674,GO:0003824,GO:0004014,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576	4.1.1.50	ko:K01611	ko00270,ko00330,ko01100,map00270,map00330,map01100	M00034,M00133	R00178	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	iPC815.YPO3412,iSDY_1059.SDY_0027	AdoMet_dc
k59_1170899_1	314230.DSM3645_13288	9.04e-16	77.8	2E99N@1|root,333HT@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1170901_1	1123060.JONP01000054_gene5553	3.41e-06	54.7	COG0784@1|root,COG2202@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,2JPID@204441|Rhodospirillales	204441|Rhodospirillales	T	signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,Response_reg
k59_1059661_1	1125699.HMPREF9194_00860	4.51e-08	56.2	COG1475@1|root,COG1475@2|Bacteria,2J6CV@203691|Spirochaetes	203691|Spirochaetes	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1059661_2	665571.STHERM_c06590	2.96e-36	131.0	COG2129@1|root,COG2129@2|Bacteria,2J5J9@203691|Spirochaetes	203691|Spirochaetes	S	metallophosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
k59_170241_1	555779.Dthio_PD0643	2.48e-54	189.0	COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,42MSS@68525|delta/epsilon subdivisions,2WIN2@28221|Deltaproteobacteria,2M99D@213115|Desulfovibrionales	28221|Deltaproteobacteria	EQ	Hydantoinaseoxoprolinase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1638,Hydant_A_N,Hydantoinase_A
k59_1226869_1	1232683.ADIMK_0821	5.57e-55	177.0	COG3658@1|root,COG3658@2|Bacteria,1RB03@1224|Proteobacteria,1S9SA@1236|Gammaproteobacteria,46B0K@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	Prokaryotic cytochrome b561	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
k59_1059670_1	1280948.HY36_17900	2.05e-69	218.0	COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve,rve_3
k59_1226874_1	861299.J421_0282	1.34e-26	115.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_170254_1	1161401.ASJA01000014_gene1062	0.000587	40.8	COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,2U70T@28211|Alphaproteobacteria,43XM5@69657|Hyphomonadaceae	28211|Alphaproteobacteria	O	COG0229 Conserved domain frequently associated with peptide methionine sulfoxide reductase	MA20_08310	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
k59_170254_2	1123393.KB891327_gene424	1.33e-63	203.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,2VJIA@28216|Betaproteobacteria,1KS4D@119069|Hydrogenophilales	119069|Hydrogenophilales	Q	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
k59_114639_1	648757.Rvan_2843	1.91e-57	184.0	COG0582@1|root,COG0582@2|Bacteria,1P1R9@1224|Proteobacteria,2U190@28211|Alphaproteobacteria,3N6S5@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
k59_781803_1	335543.Sfum_0043	2.91e-65	221.0	COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,42M2T@68525|delta/epsilon subdivisions,2WJ2W@28221|Deltaproteobacteria,2MQYS@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	C-terminal, D2-small domain, of ClpB protein	clpA	-	-	ko:K03694	-	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_1004255_1	1121441.AUCX01000017_gene2012	1.17e-36	142.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,2M7S1@213115|Desulfovibrionales	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1226889_1	1047013.AQSP01000144_gene848	1.29e-06	55.5	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	4.2.2.6	ko:K01730	ko00040,map00040	-	R04382	RC02124,RC02427	ko00000,ko00001,ko01000	-	-	-	DUF5050,PD40,zinc_ribbon_2
k59_1617255_1	1379270.AUXF01000001_gene2009	1.09e-37	145.0	COG0515@1|root,COG0515@2|Bacteria,1ZUBQ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
k59_1617260_1	1125863.JAFN01000001_gene248	2.9e-45	157.0	COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,42QXM@68525|delta/epsilon subdivisions,2WMZI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
k59_1394967_1	1408428.JNJP01000113_gene122	1.3e-23	101.0	COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,42M28@68525|delta/epsilon subdivisions,2WJPF@28221|Deltaproteobacteria,2MA1S@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
k59_1394967_2	1121440.AUMA01000005_gene2539	1.96e-10	61.2	COG0613@1|root,COG0613@2|Bacteria,1MWIH@1224|Proteobacteria,42N9R@68525|delta/epsilon subdivisions,2WN5P@28221|Deltaproteobacteria,2M85C@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	SMART phosphoesterase PHP domain protein	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP
k59_672476_1	1057002.KB905370_gene3999	4.28e-16	82.8	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4B9BA@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,TPR_19
k59_116290_1	861299.J421_6286	3.4e-46	163.0	COG3653@1|root,COG3653@2|Bacteria,1ZTFY@142182|Gemmatimonadetes	142182|Gemmatimonadetes	Q	Amidohydrolase family	-	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
k59_116290_2	997346.HMPREF9374_0221	6.83e-08	57.0	COG1649@1|root,COG1649@2|Bacteria,1TRTG@1239|Firmicutes,4HD0M@91061|Bacilli	91061|Bacilli	N	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	GHL10
k59_338551_1	56780.SYN_02972	3.62e-38	134.0	COG0632@1|root,COG0632@2|Bacteria,1MWJR@1224|Proteobacteria,42RPS@68525|delta/epsilon subdivisions,2WPH5@28221|Deltaproteobacteria,2MQJQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	-	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
k59_1394973_1	671143.DAMO_1011	4.45e-39	144.0	COG1222@1|root,COG1222@2|Bacteria	2|Bacteria	O	protein catabolic process	-	-	-	ko:K13525,ko:K13527	ko03050,ko04141,ko05134,map03050,map04141,map05134	M00342,M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko03051,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N
k59_1394973_2	926550.CLDAP_21010	1.16e-08	56.2	COG2203@1|root,COG4585@1|root,COG2203@2|Bacteria,COG4585@2|Bacteria,2G6ZM@200795|Chloroflexi	200795|Chloroflexi	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA_3
k59_338553_1	314278.NB231_15338	9.34e-37	134.0	COG1183@1|root,COG1183@2|Bacteria,1MWD9@1224|Proteobacteria,1RPBB@1236|Gammaproteobacteria,1WWDZ@135613|Chromatiales	135613|Chromatiales	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_transf
k59_338563_1	311424.DhcVS_736	7.44e-33	120.0	COG0440@1|root,COG0440@2|Bacteria,2G6NW@200795|Chloroflexi,34D5M@301297|Dehalococcoidia	301297|Dehalococcoidia	E	ACT domain	ilvN	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT_5,ALS_ss_C
k59_1561820_1	1463926.JOCA01000005_gene3307	2.51e-21	92.4	COG0730@1|root,COG0730@2|Bacteria,2IIY7@201174|Actinobacteria	201174|Actinobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
k59_783513_1	106370.Francci3_4135	1.26e-25	103.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	eryCVI	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0016999,GO:0017000,GO:0017144,GO:0032259,GO:0042802,GO:0042803,GO:0044237,GO:0044249,GO:0046983	2.1.1.234	ko:K13311,ko:K13326,ko:K21335	ko00523,ko01130,map00523,map01130	M00797,M00800	R06427,R11045,R11476	RC00003,RC01515,RC02262	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_25
k59_505667_1	1123239.KB898636_gene2779	1.79e-09	63.9	COG1988@1|root,COG1988@2|Bacteria,1TT3S@1239|Firmicutes,4HDWS@91061|Bacilli	91061|Bacilli	S	LexA-binding, inner membrane-associated putative hydrolase	-	-	-	ko:K07038	-	-	-	-	ko00000	-	-	-	YdjM
k59_672500_1	1007105.PT7_1900	2.52e-107	322.0	COG0683@1|root,COG0683@2|Bacteria,1MWNB@1224|Proteobacteria,2VKVZ@28216|Betaproteobacteria,3T355@506|Alcaligenaceae	28216|Betaproteobacteria	E	ABC-type branched-chain amino acid transport systems periplasmic component	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_450150_1	330084.JNYZ01000003_gene2235	1.84e-45	163.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4DZ78@85010|Pseudonocardiales	201174|Actinobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
k59_172011_1	1267533.KB906734_gene3758	4.51e-72	226.0	COG0500@1|root,COG2226@2|Bacteria,3Y4HC@57723|Acidobacteria	57723|Acidobacteria	Q	Hypothetical methyltransferase	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
k59_1006081_1	324925.Ppha_1586	1.04e-09	58.5	COG5649@1|root,COG5649@2|Bacteria	2|Bacteria	E	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
k59_1395010_1	1541065.JRFE01000059_gene5693	3.14e-109	331.0	COG3385@1|root,COG3385@2|Bacteria,1G2YX@1117|Cyanobacteria,3VMCZ@52604|Pleurocapsales	1117|Cyanobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
k59_1228856_1	379066.GAU_0131	3.63e-52	181.0	COG0673@1|root,COG0673@2|Bacteria,1ZSW3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
k59_672519_1	1037409.BJ6T_58680	3.77e-50	180.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria,3JQVN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	MA20_27485	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_1283920_1	991.IW20_00675	4.12e-11	68.6	COG0642@1|root,COG0745@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,4NFEF@976|Bacteroidetes,1HXAX@117743|Flavobacteriia,2NSYK@237|Flavobacterium	976|Bacteroidetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,Response_reg
k59_1617314_1	243230.DR_0853	5.29e-58	187.0	COG1100@1|root,COG1100@2|Bacteria,1WJAD@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM ADP-ribosylation factor family	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	Arf
k59_839015_1	909663.KI867150_gene80	1.4e-35	138.0	COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,43BFJ@68525|delta/epsilon subdivisions,2X6TY@28221|Deltaproteobacteria,2MQ4R@213462|Syntrophobacterales	1224|Proteobacteria	J	GAD domain	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
k59_5449_1	1114970.PSF113_1495	0.000816	47.4	2DMIH@1|root,32RT1@2|Bacteria,1RDKU@1224|Proteobacteria,1S9NM@1236|Gammaproteobacteria,1YP45@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_283355_1	246196.MSMEI_4528	2.47e-35	140.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,2GKXV@201174|Actinobacteria,235IC@1762|Mycobacteriaceae	201174|Actinobacteria	C	ferredoxin oxidoreductase	korA	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0030312,GO:0044464,GO:0050896,GO:0055114,GO:0071944	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
k59_239805_2	264732.Moth_0229	1.48e-11	66.2	COG0653@1|root,COG0653@2|Bacteria,1TPEY@1239|Firmicutes,247N2@186801|Clostridia,42ETW@68295|Thermoanaerobacterales	186801|Clostridia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_1518134_1	525904.Tter_1593	1.87e-07	53.5	COG2010@1|root,COG2010@2|Bacteria,2NPSE@2323|unclassified Bacteria	2|Bacteria	C	Protein of unknown function (DUF3341)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3341
k59_850410_1	563192.HMPREF0179_00821	7.08e-70	234.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,42MKB@68525|delta/epsilon subdivisions,2WJ4W@28221|Deltaproteobacteria,2M8QH@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
k59_1407209_1	762211.BSTEL_1097	2.42e-18	87.0	COG0216@1|root,COG0216@2|Bacteria,2GJWG@201174|Actinobacteria,4CYX4@85004|Bifidobacteriales	201174|Actinobacteria	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	GO:0008150,GO:0040007	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
k59_1407210_1	402881.Plav_0937	8.94e-56	194.0	COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,2TS4D@28211|Alphaproteobacteria,1JQFD@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Penicillin amidase	-	-	3.5.1.11,3.5.1.97	ko:K01434,ko:K07116	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
k59_127642_2	1120953.AUBH01000006_gene2547	7.42e-28	115.0	COG0457@1|root,COG0457@2|Bacteria,1Q3YA@1224|Proteobacteria,1RN2D@1236|Gammaproteobacteria,46595@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Peptidase family M49	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M49
k59_1462901_1	987059.RBXJA2T_08590	3.4e-110	329.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2VKRZ@28216|Betaproteobacteria,1KITC@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.18	ko:K00822	ko00280,ko00410,ko00640,ko01100,map00280,map00410,map00640,map01100	-	R00907,R04187	RC00008,RC00062,RC00160	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_3
k59_962495_1	402881.Plav_3006	8.06e-102	319.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,2TS9E@28211|Alphaproteobacteria,1JN8E@119043|Rhodobiaceae	28211|Alphaproteobacteria	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
k59_1518151_1	570967.JMLV01000001_gene2797	7.36e-35	135.0	COG0529@1|root,COG2895@1|root,COG0529@2|Bacteria,COG2895@2|Bacteria,1MUD9@1224|Proteobacteria,2TQNJ@28211|Alphaproteobacteria,2JPGB@204441|Rhodospirillales	204441|Rhodospirillales	P	Catalyzes the synthesis of activated sulfate	cysC	-	2.7.1.25,2.7.7.4	ko:K00955	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176	R00509,R00529,R04928,R04929	RC00002,RC00078,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase,GTP_EFTU
k59_572642_1	530564.Psta_2929	3.34e-79	254.0	COG0843@1|root,COG0843@2|Bacteria,2IXCQ@203682|Planctomycetes	203682|Planctomycetes	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_1685108_2	1500306.JQLA01000003_gene4763	1.38e-46	161.0	COG3547@1|root,COG3547@2|Bacteria,1Q4TE@1224|Proteobacteria,2TT7C@28211|Alphaproteobacteria,4BB4U@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_295309_1	1380390.JIAT01000009_gene2139	3.27e-39	140.0	COG0637@1|root,COG0637@2|Bacteria,2I6IT@201174|Actinobacteria,4CRIS@84995|Rubrobacteria	84995|Rubrobacteria	S	HAD-superfamily hydrolase subfamily IA, variant 3	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
k59_740330_1	1255043.TVNIR_2414	9.86e-34	129.0	COG0709@1|root,COG1252@1|root,COG0709@2|Bacteria,COG1252@2|Bacteria,1MWFG@1224|Proteobacteria,1RQ5Q@1236|Gammaproteobacteria,1X13W@135613|Chromatiales	135613|Chromatiales	CE	AIR synthase related protein, N-terminal domain	-	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C,Pyr_redox_2
k59_1462914_1	926569.ANT_05230	3.45e-94	292.0	COG0322@1|root,COG0322@2|Bacteria,2G651@200795|Chloroflexi	200795|Chloroflexi	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
k59_239841_1	926569.ANT_31720	7.51e-96	295.0	COG2987@1|root,COG2987@2|Bacteria,2G5PQ@200795|Chloroflexi	200795|Chloroflexi	E	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
k59_907592_1	877421.AUJT01000001_gene1999	6.77e-77	257.0	COG1674@1|root,COG1674@2|Bacteria,1TPJR@1239|Firmicutes,247KM@186801|Clostridia,27J34@186928|unclassified Lachnospiraceae	186801|Clostridia	D	Ftsk_gamma	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
k59_1685135_1	926569.ANT_06480	6.81e-75	241.0	COG0381@1|root,COG0381@2|Bacteria	2|Bacteria	M	UDP-N-acetylglucosamine 2-epimerase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_795875_1	1120956.JHZK01000014_gene1792	6.21e-29	115.0	COG0561@1|root,COG0561@2|Bacteria,1R4WX@1224|Proteobacteria,2TSDR@28211|Alphaproteobacteria,1JPPH@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
k59_295328_1	519989.ECTPHS_04955	1.19e-53	184.0	COG1030@1|root,COG1030@2|Bacteria,1MUJN@1224|Proteobacteria,1RN3U@1236|Gammaproteobacteria,1WXRD@135613|Chromatiales	135613|Chromatiales	O	NfeD-like C-terminal, partner-binding	-	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	NfeD
k59_1685140_2	926569.ANT_06720	4.3e-37	131.0	COG3877@1|root,COG3877@2|Bacteria,2G734@200795|Chloroflexi	200795|Chloroflexi	S	Protein of unknown function (DUF2089)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2089
k59_1241873_1	1048834.TC41_2569	7.61e-38	137.0	COG0483@1|root,COG0483@2|Bacteria,1UKWB@1239|Firmicutes,4ITKN@91061|Bacilli	91061|Bacilli	G	Inositol monophosphatase family	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
k59_239863_1	572544.Ilyop_0511	3.55e-19	86.3	COG2087@1|root,COG2087@2|Bacteria,37A1F@32066|Fusobacteria	32066|Fusobacteria	H	Adenosylcobinamide kinase adenosylcobinamide-phosphate guanylyltransferase	cobU	-	2.7.1.156,2.7.7.62	ko:K02231	ko00860,ko01100,map00860,map01100	M00122	R05221,R05222,R06558	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	CobU
k59_239863_2	1463864.JOGO01000013_gene5471	6.03e-12	65.1	COG0406@1|root,COG0406@2|Bacteria,2GJYU@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the phosphoglycerate mutase family	gpmB	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0044237	3.1.3.85,5.4.2.11	ko:K01834,ko:K22306	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
k59_1018655_1	313596.RB2501_07525	3.16e-27	104.0	COG0328@1|root,COG3341@1|root,COG0328@2|Bacteria,COG3341@2|Bacteria,4NI01@976|Bacteroidetes,1HXD6@117743|Flavobacteriia	976|Bacteroidetes	L	double-stranded RNA RNA-DNA hybrid binding protein	rnhA	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Cauli_VI,RNase_H
k59_1018655_2	313596.RB2501_07530	3.56e-65	203.0	COG0299@1|root,COG0299@2|Bacteria,4NNZP@976|Bacteroidetes,1I19R@117743|Flavobacteriia	976|Bacteroidetes	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N
k59_1573872_1	1144305.PMI02_02525	5e-22	93.2	COG1189@1|root,COG1189@2|Bacteria,1MWP5@1224|Proteobacteria,2TRW9@28211|Alphaproteobacteria,2K0J2@204457|Sphingomonadales	204457|Sphingomonadales	J	Hemolysin	-	-	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
k59_1573872_2	227882.SAV_5614	1.13e-13	73.9	COG0534@1|root,COG0534@2|Bacteria,2HXQ6@201174|Actinobacteria	201174|Actinobacteria	V	Na -driven multidrug efflux pump	matE	-	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
k59_1628785_1	880073.Calab_1134	3.01e-43	160.0	COG2091@1|root,COG2091@2|Bacteria,2NQGR@2323|unclassified Bacteria	2|Bacteria	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
k59_628193_1	1437425.CSEC_1813	2.55e-09	63.2	COG0306@1|root,COG0306@2|Bacteria,2JFPI@204428|Chlamydiae	204428|Chlamydiae	P	Phosphate	CP_0067	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
k59_907624_2	714943.Mucpa_5701	5.25e-25	103.0	COG2801@1|root,COG2801@2|Bacteria,4NIBY@976|Bacteroidetes,1ITSB@117747|Sphingobacteriia	976|Bacteroidetes	L	Integrase core domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
k59_127692_1	1255043.TVNIR_2131	2.65e-21	95.1	2DWMM@1|root,3411B@2|Bacteria,1R0MB@1224|Proteobacteria,1SPZG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1573903_1	1123228.AUIH01000002_gene1528	4.41e-63	208.0	COG0477@1|root,COG0477@2|Bacteria,1MWXZ@1224|Proteobacteria,1RPIM@1236|Gammaproteobacteria,1XS01@135619|Oceanospirillales	135619|Oceanospirillales	EGP	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_740395_1	926569.ANT_31100	5.72e-48	172.0	COG0747@1|root,COG0747@2|Bacteria,2G7MC@200795|Chloroflexi	200795|Chloroflexi	E	PFAM extracellular solute-binding protein, family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_572711_1	1501230.ET33_10625	1.51e-22	95.9	COG0406@1|root,COG0406@2|Bacteria,1V6ES@1239|Firmicutes,4HGZI@91061|Bacilli,26TQ1@186822|Paenibacillaceae	91061|Bacilli	G	Belongs to the phosphoglycerate mutase family	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
k59_517824_1	1097668.BYI23_C003870	4.38e-66	211.0	COG0329@1|root,COG0329@2|Bacteria,1MXM5@1224|Proteobacteria,2VIKK@28216|Betaproteobacteria,1K06U@119060|Burkholderiaceae	28216|Betaproteobacteria	EM	Belongs to the DapA family	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
k59_1351544_1	159087.Daro_3706	4.93e-33	122.0	COG0352@1|root,COG0494@1|root,COG0352@2|Bacteria,COG0494@2|Bacteria,1RCZM@1224|Proteobacteria,2VHTP@28216|Betaproteobacteria,2KVDW@206389|Rhodocyclales	206389|Rhodocyclales	HL	Belongs to the Nudix hydrolase family	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX,TMP-TENI
k59_1351544_2	1454004.AW11_03377	2.89e-45	155.0	COG2607@1|root,COG2607@2|Bacteria,1MVMX@1224|Proteobacteria,2VID5@28216|Betaproteobacteria,1KPP1@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	S	General function prediction only	-	-	-	ko:K06923	-	-	-	-	ko00000	-	-	-	DUF815
k59_1186603_1	926569.ANT_01400	2.29e-95	288.0	COG0444@1|root,COG0444@2|Bacteria,2G5PT@200795|Chloroflexi	200795|Chloroflexi	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_519654_1	1123023.JIAI01000003_gene2845	1.65e-23	101.0	COG1960@1|root,COG1960@2|Bacteria,2GKVN@201174|Actinobacteria,4DZ01@85010|Pseudonocardiales	201174|Actinobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_519654_2	525368.HMPREF0591_1482	3.33e-11	62.8	COG1960@1|root,COG1960@2|Bacteria,2GJDT@201174|Actinobacteria,233BX@1762|Mycobacteriaceae	201174|Actinobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_352130_1	1297742.A176_06079	3.94e-85	276.0	COG0639@1|root,COG4639@1|root,COG0639@2|Bacteria,COG4639@2|Bacteria,1Q3Q7@1224|Proteobacteria,4342C@68525|delta/epsilon subdivisions,2X4TK@28221|Deltaproteobacteria,2YZJY@29|Myxococcales	28221|Deltaproteobacteria	T	PNKP adenylyltransferase domain, ligase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_33,Metallophos,PNKP-ligase_C,PNKP_ligase
k59_129663_1	1121937.AUHJ01000004_gene1017	2.16e-13	71.2	COG1257@1|root,COG1257@2|Bacteria,1Q6M1@1224|Proteobacteria,1RPEP@1236|Gammaproteobacteria,46417@72275|Alteromonadaceae	1236|Gammaproteobacteria	I	Hydroxymethylglutaryl-coenzyme A reductase	-	-	1.1.1.34	ko:K00021	ko00900,ko01100,ko01110,ko01130,ko04152,ko04976,map00900,map01100,map01110,map01130,map04152,map04976	M00095	R02082	RC00004,RC00644	ko00000,ko00001,ko00002,ko01000	-	-	-	HMG-CoA_red
k59_1575760_1	1111479.AXAR01000020_gene1212	2.38e-29	120.0	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,4HDZ4@91061|Bacilli	91061|Bacilli	T	Histidine kinase	-	-	2.7.13.3	ko:K07642	ko02020,map02020	M00450,M00645,M00646,M00648	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
k59_519664_1	441620.Mpop_3738	3.55e-15	78.2	COG3293@1|root,COG3293@2|Bacteria,1RDDI@1224|Proteobacteria,2U7E3@28211|Alphaproteobacteria,1JZ12@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	Putative transposase of IS4/5 family (DUF4096)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4096
k59_1687095_2	1415780.JPOG01000001_gene279	3.74e-19	87.8	COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,1RN6K@1236|Gammaproteobacteria,1X3YZ@135614|Xanthomonadales	135614|Xanthomonadales	C	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	aceE	-	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
k59_1297772_1	1267535.KB906767_gene447	3.85e-22	100.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,3Y67Y@57723|Acidobacteria,2JMN2@204432|Acidobacteriia	204432|Acidobacteriia	T	Tetratricopeptide repeat	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_12
k59_1075336_1	329726.AM1_2826	1.93e-30	119.0	COG1266@1|root,COG1266@2|Bacteria	2|Bacteria	V	CAAX protease self-immunity	yprA	-	3.4.11.19	ko:K01266,ko:K07052	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Abi
k59_19430_2	443218.AS9A_2498	4.52e-19	89.0	COG1475@1|root,COG1475@2|Bacteria,2IAI6@201174|Actinobacteria	201174|Actinobacteria	K	DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	ParBc
k59_852235_2	1121129.KB903372_gene307	9.29e-05	45.4	COG1595@1|root,COG1595@2|Bacteria,4NRE8@976|Bacteroidetes,2FSP5@200643|Bacteroidia,22YM8@171551|Porphyromonadaceae	976|Bacteroidetes	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_1243891_1	518766.Rmar_0925	1.04e-93	307.0	COG1472@1|root,COG1680@1|root,COG1472@2|Bacteria,COG1680@2|Bacteria,4NET8@976|Bacteroidetes,1FJ9E@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	G	Glycosyl hydrolase family 3 N terminal domain	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Beta-lactamase,Glyco_hydro_3,Glyco_hydro_3_C
k59_1297784_1	99158.XP_008888960.1	1.21e-26	109.0	2ETI4@1|root,2SVV3@2759|Eukaryota	2759|Eukaryota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_1297784_2	1187851.A33M_1637	2.18e-29	112.0	COG1484@1|root,COG1484@2|Bacteria,1MVU2@1224|Proteobacteria,2U0PH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	ATP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21,IstB_IS21_ATP
k59_1020597_1	1400525.JNIU01000001_gene520	2.77e-161	468.0	COG1053@1|root,COG1053@2|Bacteria,1NZBR@1224|Proteobacteria,2TSN4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	succinate dehydrogenase fumarate reductase, flavoprotein subunit	MA20_14860	-	1.8.99.2	ko:K00394	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00596	R00860,R04927,R08553	RC00007,RC01239,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_19448_1	930171.Asphe3_39500	1.22e-35	135.0	2EE91@1|root,3383F@2|Bacteria,2IAWN@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1630661_1	926562.Oweho_2291	5.96e-08	58.5	COG2931@1|root,COG4222@1|root,COG2931@2|Bacteria,COG4222@2|Bacteria,4NKF1@976|Bacteroidetes,1II60@117743|Flavobacteriia,2PBH9@246874|Cryomorphaceae	976|Bacteroidetes	Q	A domain in the BMP inhibitor chordin and in microbial proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CHRD,SusE
k59_464857_1	321327.CYA_1599	1.26e-46	164.0	COG1226@1|root,COG1226@2|Bacteria,1G0WK@1117|Cyanobacteria,1GYWE@1129|Synechococcus	1117|Cyanobacteria	P	potassium channel, VIC family protein	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2,TrkA_C,TrkA_N
k59_1075364_1	96561.Dole_1367	1.06e-31	127.0	COG0515@1|root,COG4252@1|root,COG0515@2|Bacteria,COG4252@2|Bacteria,1MV1P@1224|Proteobacteria,42Q67@68525|delta/epsilon subdivisions,2WKZ1@28221|Deltaproteobacteria,2MHTH@213118|Desulfobacterales	28221|Deltaproteobacteria	KLT	PFAM Protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	CHASE2,Pkinase
k59_1131795_1	414684.RC1_0930	9.26e-56	177.0	COG0757@1|root,COG0757@2|Bacteria,1RDDT@1224|Proteobacteria,2U9BV@28211|Alphaproteobacteria,2JS4I@204441|Rhodospirillales	204441|Rhodospirillales	E	Catalyzes a trans-dehydration via an enolate intermediate	aroQ	-	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
k59_630051_1	68194.JNXR01000021_gene809	9.51e-82	273.0	COG0318@1|root,COG0604@1|root,COG3321@1|root,COG0318@2|Bacteria,COG0604@2|Bacteria,COG3321@2|Bacteria,2H477@201174|Actinobacteria	201174|Actinobacteria	Q	polyketide synthase	-	-	-	ko:K21792	ko00333,ko01130,map00333,map01130	M00838	R11664	-	ko00000,ko00001,ko00002	-	-	-	ADH_N,ADH_zinc_N,AMP-binding,Acyl_transf_1,Aminotran_1_2,Aminotran_3,Condensation,Epimerase,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
k59_1520114_1	1173024.KI912149_gene5854	1.06e-44	162.0	COG0457@1|root,COG0457@2|Bacteria,1GDHI@1117|Cyanobacteria	1117|Cyanobacteria	S	K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_185691_2	1121441.AUCX01000007_gene1075	2.46e-18	78.6	2DNYP@1|root,32ZTI@2|Bacteria,1N747@1224|Proteobacteria,42XZ1@68525|delta/epsilon subdivisions,2WTGJ@28221|Deltaproteobacteria,2ME5V@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF2905)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2905
k59_297296_1	926569.ANT_25660	5.2e-45	172.0	COG2373@1|root,COG2373@2|Bacteria,2G5XN@200795|Chloroflexi	200795|Chloroflexi	S	PFAM alpha-2-macroglobulin domain protein	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,A2M_comp,Big_5,MG1
k59_241671_1	394221.Mmar10_0331	1.57e-20	92.8	COG4783@1|root,COG5616@1|root,COG4783@2|Bacteria,COG5616@2|Bacteria,1NSKC@1224|Proteobacteria,2TWZ1@28211|Alphaproteobacteria,44159@69657|Hyphomonadaceae	28211|Alphaproteobacteria	K	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,Trans_reg_C
k59_909750_1	1380394.JADL01000003_gene4756	9.13e-73	228.0	COG2159@1|root,COG2159@2|Bacteria,1N0C7@1224|Proteobacteria,2TRXY@28211|Alphaproteobacteria,2JUHF@204441|Rhodospirillales	204441|Rhodospirillales	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
k59_74693_1	78245.Xaut_2223	5.74e-50	173.0	COG0665@1|root,COG0665@2|Bacteria,1N1TN@1224|Proteobacteria,2TR7B@28211|Alphaproteobacteria,3F043@335928|Xanthobacteraceae	28211|Alphaproteobacteria	E	FAD dependent oxidoreductase	thiO	-	1.4.3.19	ko:K03153	ko00730,ko01100,map00730,map01100	-	R07463	RC01788	ko00000,ko00001,ko01000	-	-	-	DAO
k59_742265_1	272123.Anacy_1192	1.69e-43	161.0	COG3280@1|root,COG3280@2|Bacteria,1G3IR@1117|Cyanobacteria,1HJ29@1161|Nostocales	1117|Cyanobacteria	G	malto-oligosyltrehalose synthase	treY	-	5.4.99.15	ko:K06044	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01824,R09995	-	ko00000,ko00001,ko00002,ko01000	-	GH13	-	Alpha-amylase
k59_464887_1	266117.Rxyl_2307	1.57e-12	67.8	COG0483@1|root,COG0483@2|Bacteria,2GKZZ@201174|Actinobacteria,4CTRC@84995|Rubrobacteria	84995|Rubrobacteria	G	Inositol monophosphatase family	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
k59_464887_2	1476583.DEIPH_ctg017orf0060	1.49e-50	169.0	COG0813@1|root,COG0813@2|Bacteria,1WIF6@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	F	TIGRFAM purine-nucleoside phosphorylase, family 1 (deoD)	-	-	2.4.2.1	ko:K03784	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
k59_687081_1	1430440.MGMSRv2_2814	4.31e-27	112.0	COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,2TQSP@28211|Alphaproteobacteria,2JPXK@204441|Rhodospirillales	204441|Rhodospirillales	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
k59_1020661_1	266835.14023943	3.27e-51	174.0	COG4213@1|root,COG4213@2|Bacteria,1MX63@1224|Proteobacteria,2TQQW@28211|Alphaproteobacteria,43H4T@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	ABC transporter substrate-binding protein	xylF	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005975,GO:0005996,GO:0006810,GO:0008150,GO:0008152,GO:0008643,GO:0015749,GO:0015750,GO:0015753,GO:0019321,GO:0030246,GO:0030288,GO:0030313,GO:0031975,GO:0034219,GO:0036094,GO:0042597,GO:0042732,GO:0044238,GO:0044281,GO:0044464,GO:0048029,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071704	-	ko:K10543	ko02010,map02010	M00215	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.4	-	-	Peripla_BP_4
k59_1534952_1	395493.BegalDRAFT_2970	2.77e-62	215.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,461EP@72273|Thiotrichales	72273|Thiotrichales	T	Methyl-accepting chemotaxis protein (MCP) signaling domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,MCPsignal
k59_1534956_1	1121904.ARBP01000031_gene570	2.95e-41	155.0	COG1629@1|root,COG4206@1|root,COG1629@2|Bacteria,COG4206@2|Bacteria,4NDXS@976|Bacteroidetes,47NQN@768503|Cytophagia	976|Bacteroidetes	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Plug,STN,TonB_dep_Rec
k59_313015_1	1304275.C41B8_11553	2.97e-17	82.8	COG3425@1|root,COG3425@2|Bacteria,1MU4K@1224|Proteobacteria,1S16F@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	synthase	-	-	2.3.3.10	ko:K01641,ko:K15311	ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130	M00088,M00095	R01978	RC00004,RC00503	ko00000,ko00001,ko00002,ko01000,ko01008	-	-	-	HMG_CoA_synt_C,HMG_CoA_synt_N
k59_1480229_1	1238182.C882_0663	4.59e-58	203.0	COG1215@1|root,COG2931@1|root,COG1215@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,2JRKY@204441|Rhodospirillales	204441|Rhodospirillales	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind,Polysacc_lyase
k59_1423999_1	1095767.CAHD01000142_gene2239	3.33e-44	165.0	COG0366@1|root,COG1523@1|root,COG0366@2|Bacteria,COG1523@2|Bacteria,2GKK1@201174|Actinobacteria,4F10I@85016|Cellulomonadaceae	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 13 family	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,Alpha-amylase_C,CBM_48,DUF3372
k59_866880_1	314278.NB231_11879	2.4e-42	153.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1WW4B@135613|Chromatiales	135613|Chromatiales	T	response regulator	-	-	-	ko:K07715	ko02020,ko02024,map02020,map02024	M00502	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Sigma54_activat
k59_313049_1	1379270.AUXF01000003_gene3408	6.65e-87	270.0	COG1220@1|root,COG1220@2|Bacteria,1ZSVP@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	-	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA_2,ClpB_D2-small
k59_1591254_1	671143.DAMO_0779	2.2e-83	261.0	COG2010@1|root,COG2010@2|Bacteria,2NR8D@2323|unclassified Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
k59_812710_1	1121033.AUCF01000004_gene4926	1.58e-49	177.0	COG5426@1|root,COG5426@2|Bacteria,1MVWA@1224|Proteobacteria,2TQNQ@28211|Alphaproteobacteria,2JQ89@204441|Rhodospirillales	204441|Rhodospirillales	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1756287_1	1292034.OR37_01891	3.4e-31	122.0	COG1680@1|root,COG1680@2|Bacteria,1N0SQ@1224|Proteobacteria,2VFFH@28211|Alphaproteobacteria,2KJT0@204458|Caulobacterales	204458|Caulobacterales	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_1756287_2	861299.J421_1323	4.26e-10	59.7	COG0137@1|root,COG0137@2|Bacteria,1ZTYP@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Arginosuccinate synthase	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
k59_255950_2	1131813.AQVT01000001_gene1196	4.58e-36	132.0	COG2514@1|root,COG2514@2|Bacteria,1RAPY@1224|Proteobacteria,2VG64@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	glyoxalase bleomycin resistance protein dioxygenase	-	-	1.13.11.2	ko:K07104	ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220	M00569	R00816,R04089,R05295,R05404,R05406,R07795	RC00387,RC00643,RC01075,RC01364,RC01914	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase
k59_756877_1	867903.ThesuDRAFT_00417	1.23e-43	148.0	COG1225@1|root,COG1225@2|Bacteria,1UV64@1239|Firmicutes,24HTS@186801|Clostridia	186801|Clostridia	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
k59_255951_1	83406.HDN1F_00950	3.22e-41	147.0	COG3434@1|root,COG3434@2|Bacteria,1MVW1@1224|Proteobacteria,1RS25@1236|Gammaproteobacteria,1J5UR@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	HDOD domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,HDOD
k59_255951_2	948565.AFFP02000011_gene1879	6.53e-12	59.7	COG0267@1|root,COG0267@2|Bacteria,1N6QV@1224|Proteobacteria,1SCEJ@1236|Gammaproteobacteria,1Y9AR@135625|Pasteurellales	135625|Pasteurellales	J	Belongs to the bacterial ribosomal protein bL33 family	rpmG	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
k59_33917_1	1122179.KB890413_gene4714	3.59e-118	352.0	COG1228@1|root,COG1228@2|Bacteria,4NFI3@976|Bacteroidetes,1IWRU@117747|Sphingobacteriia	976|Bacteroidetes	Q	COGs COG1228 Imidazolonepropionase and related amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_866909_1	1313421.JHBV01000003_gene656	7.18e-39	135.0	COG0346@1|root,COG0346@2|Bacteria,4NNNG@976|Bacteroidetes,1IT31@117747|Sphingobacteriia	976|Bacteroidetes	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
k59_367368_1	1123258.AQXZ01000016_gene2575	8.3e-53	183.0	COG2197@1|root,COG2206@1|root,COG2197@2|Bacteria,COG2206@2|Bacteria,2GJS8@201174|Actinobacteria,4FVWD@85025|Nocardiaceae	201174|Actinobacteria	KT	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,HD_5
k59_589586_1	1198114.AciX9_2240	0.000526	44.7	COG0249@1|root,COG0249@2|Bacteria,3Y2J5@57723|Acidobacteria,2JHTC@204432|Acidobacteriia	204432|Acidobacteriia	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
k59_89642_1	926569.ANT_18190	1.03e-14	73.9	COG1774@1|root,COG1774@2|Bacteria,2G6AJ@200795|Chloroflexi	200795|Chloroflexi	NU	PFAM PSP1 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PSP1
k59_534630_1	1079460.ATTQ01000033_gene4038	1.3e-47	155.0	COG2963@1|root,COG2963@2|Bacteria,1RI5X@1224|Proteobacteria,2UBB0@28211|Alphaproteobacteria,4BHNS@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Transposase	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_534630_2	1297865.APJD01000051_gene6887	4.52e-18	81.6	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2U0FG@28211|Alphaproteobacteria,3JWTA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
k59_199923_1	1173025.GEI7407_3200	1.39e-41	153.0	COG1231@1|root,COG1231@2|Bacteria,1G18A@1117|Cyanobacteria,1H6YY@1150|Oscillatoriales	1117|Cyanobacteria	E	Monoamine oxidase	-	-	1.4.3.4	ko:K00274	ko00260,ko00330,ko00340,ko00350,ko00360,ko00380,ko00950,ko00982,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00260,map00330,map00340,map00350,map00360,map00380,map00950,map00982,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00135	R02173,R02382,R02529,R02532,R02613,R02908,R02919,R04025,R04300,R04674,R04890,R04893,R04894,R04907,R04908,R08346,R08347,R08348,R11354	RC00062,RC00160,RC00225,RC00676,RC00807,RC00808,RC01808,RC02226,RC02713	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
k59_481072_1	365528.KB891262_gene5089	9.71e-39	140.0	COG2124@1|root,COG2124@2|Bacteria,2GJ3T@201174|Actinobacteria	201174|Actinobacteria	Q	cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
k59_481072_2	246196.MSMEI_4762	8.32e-21	91.3	COG2124@1|root,COG2124@2|Bacteria,2GJ3T@201174|Actinobacteria,232IM@1762|Mycobacteriaceae	201174|Actinobacteria	Q	cytochrome p450	-	-	-	-	-	-	-	-	-	-	-	-	p450
k59_1368945_1	1461582.BN1048_00102	1.14e-08	60.5	COG1802@1|root,COG1802@2|Bacteria,1UKN3@1239|Firmicutes,4HD90@91061|Bacilli,4GZHV@90964|Staphylococcaceae	91061|Bacilli	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
k59_866965_1	760117.JN27_09935	1.04e-14	75.1	COG1960@1|root,COG1960@2|Bacteria,1MVJC@1224|Proteobacteria,2VIQT@28216|Betaproteobacteria,473D7@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	Acyl-CoA dehydrogenase, middle domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_866965_2	1380394.JADL01000001_gene1988	5.17e-28	112.0	COG1960@1|root,COG1960@2|Bacteria,1MUBH@1224|Proteobacteria,2TSKH@28211|Alphaproteobacteria,2JR6R@204441|Rhodospirillales	204441|Rhodospirillales	I	Acyl-CoA dehydrogenase, middle domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_1756347_1	269799.Gmet_3404	8.98e-69	222.0	COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,42NJJ@68525|delta/epsilon subdivisions,2WJGI@28221|Deltaproteobacteria,43SZG@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)	pdxA	-	1.1.1.262,1.1.1.408,1.1.1.409	ko:K00097,ko:K22024	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxA
k59_702442_1	861299.J421_2768	2.61e-58	203.0	COG0086@1|root,COG0086@2|Bacteria,1ZSZQ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_1147211_1	485914.Hmuk_2730	1.23e-42	159.0	COG0188@1|root,arCOG04367@2157|Archaea,2XTZV@28890|Euryarchaeota,23S8P@183963|Halobacteria	183963|Halobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_1368960_1	1120953.AUBH01000004_gene3093	2.1e-37	137.0	COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,1RNB8@1236|Gammaproteobacteria,464PM@72275|Alteromonadaceae	1236|Gammaproteobacteria	O	COG1404 Subtilisin-like serine proteases	-	-	-	ko:K14645	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	PKD,Peptidase_S8
k59_1705936_1	926569.ANT_18070	1.43e-42	146.0	COG0698@1|root,COG0698@2|Bacteria,2G6SM@200795|Chloroflexi	200795|Chloroflexi	G	Ribose/Galactose Isomerase	rpiB	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
k59_1261296_1	383372.Rcas_4054	1.2e-30	119.0	COG0477@1|root,COG2814@2|Bacteria,2G71K@200795|Chloroflexi	200795|Chloroflexi	EGP	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1261296_2	1255043.TVNIR_2084	1.6e-12	64.7	COG0317@1|root,COG0317@2|Bacteria,1RGUA@1224|Proteobacteria,1S3WT@1236|Gammaproteobacteria,1WY7Z@135613|Chromatiales	135613|Chromatiales	KT	HD domain	-	-	2.7.6.5,3.1.7.2	ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	HD_4
k59_1482423_1	234267.Acid_6592	5.99e-35	133.0	COG0153@1|root,COG0153@2|Bacteria,3Y300@57723|Acidobacteria	2|Bacteria	G	Belongs to the GHMP kinase family. GalK subfamily	-	-	2.7.1.6	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00554,M00632	R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
k59_1039356_1	1282876.BAOK01000001_gene2154	2.48e-69	231.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,2TQTB@28211|Alphaproteobacteria,4BPAV@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	ntrY	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.13.3	ko:K13598	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4
k59_704286_1	1282876.BAOK01000002_gene944	1.78e-84	258.0	COG0559@1|root,COG0559@2|Bacteria,1MVND@1224|Proteobacteria,2TRMA@28211|Alphaproteobacteria,4BREC@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_257644_1	311424.DhcVS_776	3.47e-105	311.0	COG2801@1|root,COG2801@2|Bacteria,2G8GQ@200795|Chloroflexi,34DDP@301297|Dehalococcoidia	301297|Dehalococcoidia	L	PFAM Integrase catalytic region	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
k59_591489_1	1444310.JANV01000170_gene2322	1.74e-37	144.0	COG4467@1|root,COG4467@2|Bacteria,1VK8R@1239|Firmicutes,4HYEG@91061|Bacilli	91061|Bacilli	S	Transposase IS66 family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66,zf-IS66
k59_201585_1	1379270.AUXF01000001_gene2788	6.1e-13	65.5	2CA00@1|root,344QM@2|Bacteria,1ZU1Z@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1758037_1	1206725.BAFU01000052_gene1571	7.02e-18	90.9	COG1232@1|root,COG3349@1|root,COG1232@2|Bacteria,COG3349@2|Bacteria,2IAFV@201174|Actinobacteria,4FUEJ@85025|Nocardiaceae	201174|Actinobacteria	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
k59_1593462_1	1128421.JAGA01000002_gene1399	1.66e-62	206.0	COG1032@1|root,COG1032@2|Bacteria,2NQJQ@2323|unclassified Bacteria	2|Bacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
k59_983095_1	1151061.CAJY01000040_gene4101	4.79e-58	201.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2GJY2@201174|Actinobacteria	201174|Actinobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0030312,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_1149099_1	1126627.BAWE01000004_gene3980	1.5e-19	87.8	COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,2TQU9@28211|Alphaproteobacteria,3JUA7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
k59_1149099_2	1121033.AUCF01000001_gene2353	8.91e-40	135.0	COG2927@1|root,COG2927@2|Bacteria,1RGVC@1224|Proteobacteria,2U94V@28211|Alphaproteobacteria,2JSPN@204441|Rhodospirillales	204441|Rhodospirillales	L	DNA polymerase III, chi subunit	holC	-	2.7.7.7	ko:K02339	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_chi
k59_928424_1	393283.XP_007830485.1	9.78e-23	100.0	COG3227@1|root,2SHBN@2759|Eukaryota,39Z00@33154|Opisthokonta,3P0MS@4751|Fungi,3QRD7@4890|Ascomycota,213RS@147550|Sordariomycetes	4751|Fungi	E	Thermolysin metallopeptidase, alpha-helical domain	-	-	-	-	-	-	-	-	-	-	-	-	PLN_propep,Peptidase_M4,Peptidase_M4_C
k59_869440_1	224911.27349722	1.58e-30	123.0	COG0840@1|root,COG2770@1|root,COG0840@2|Bacteria,COG2770@2|Bacteria,1MU9B@1224|Proteobacteria,2TQR7@28211|Alphaproteobacteria,3JUBC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	NT	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer).	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,MCPsignal
k59_1536713_1	861299.J421_2807	3e-45	159.0	COG0104@1|root,COG0104@2|Bacteria,1ZSNV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
k59_91546_1	483219.LILAB_35055	7.52e-16	77.4	COG3016@1|root,COG3016@2|Bacteria,1MX1I@1224|Proteobacteria,42U2R@68525|delta/epsilon subdivisions,2WM9S@28221|Deltaproteobacteria,2YZVS@29|Myxococcales	28221|Deltaproteobacteria	S	Haem-binding uptake, Tiki superfamily, ChaN	-	-	-	-	-	-	-	-	-	-	-	-	Cofac_haem_bdg,PDZ_2
k59_91546_2	768671.ThimaDRAFT_2311	0.000701	43.9	COG2919@1|root,COG2919@2|Bacteria,1N7AA@1224|Proteobacteria,1SD8H@1236|Gammaproteobacteria,1WZ9J@135613|Chromatiales	135613|Chromatiales	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic	ftsB	-	-	ko:K05589	-	-	-	-	ko00000,ko03036	-	-	-	DivIC
k59_1316590_1	449447.MAE_19550	2.05e-17	85.5	COG1808@1|root,COG1808@2|Bacteria,1G157@1117|Cyanobacteria	1117|Cyanobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF389
k59_1203654_1	596152.DesU5LDRAFT_3068	6.99e-10	59.3	COG0642@1|root,COG2205@2|Bacteria,1MW8M@1224|Proteobacteria,42SW9@68525|delta/epsilon subdivisions,2WPN3@28221|Deltaproteobacteria,2M9KZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
k59_1203654_2	391600.ABRU01000021_gene927	4.33e-05	45.1	COG0007@1|root,COG1648@1|root,COG0007@2|Bacteria,COG1648@2|Bacteria,1MUI0@1224|Proteobacteria,2TRJC@28211|Alphaproteobacteria,2KG1D@204458|Caulobacterales	204458|Caulobacterales	H	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme	-	-	1.3.1.76,2.1.1.107,4.99.1.4	ko:K02302,ko:K02303	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03194,R03947	RC00003,RC00871,RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	CysG_dimeriser,NAD_binding_7,Sirohm_synth_M,TP_methylase
k59_1482482_1	926569.ANT_09460	3.39e-38	143.0	COG4856@1|root,COG4856@2|Bacteria,2G75D@200795|Chloroflexi	200795|Chloroflexi	S	PFAM YbbR family protein	-	-	-	-	-	-	-	-	-	-	-	-	YbbR
k59_983125_1	861299.J421_1523	6.22e-59	199.0	COG0318@1|root,COG0318@2|Bacteria	2|Bacteria	IQ	PFAM AMP-dependent synthetase and ligase	alkK	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_1593519_1	1387312.BAUS01000002_gene1041	0.000338	48.1	COG0491@1|root,COG0491@2|Bacteria,1MU8Q@1224|Proteobacteria,2VGZG@28216|Betaproteobacteria,2KKV3@206350|Nitrosomonadales	206350|Nitrosomonadales	S	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	gloB	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	HAGH_C,Lactamase_B
k59_257709_1	941824.TCEL_00933	7.14e-48	174.0	COG0210@1|root,COG0210@2|Bacteria,1TPSU@1239|Firmicutes,247RM@186801|Clostridia,36DGD@31979|Clostridiaceae	186801|Clostridia	L	ATP-dependent DNA helicase	pcrA	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_1426039_1	357808.RoseRS_0091	8.06e-50	178.0	COG0587@1|root,COG0587@2|Bacteria,2G5IY@200795|Chloroflexi,3757Q@32061|Chloroflexia	32061|Chloroflexia	L	TIGRFAM DNA polymerase III, alpha subunit	-	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_369578_1	1121939.L861_01515	7.03e-101	297.0	COG0262@1|root,COG0262@2|Bacteria,1R5UU@1224|Proteobacteria,1S5G9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	dihydrofolate reductase	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
k59_146511_1	1122135.KB893146_gene1459	1.48e-51	169.0	COG0204@1|root,COG0204@2|Bacteria,1RA8V@1224|Proteobacteria,2U5DY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Acyl-transferase	plsC	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
k59_536653_1	68170.KL590535_gene3960	8.11e-25	108.0	COG4995@1|root,COG4995@2|Bacteria,2GKCX@201174|Actinobacteria,4DZ5H@85010|Pseudonocardiales	201174|Actinobacteria	K	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT
k59_1608305_1	1121930.AQXG01000001_gene1200	2.18e-25	109.0	COG1538@1|root,COG1538@2|Bacteria,4NF4X@976|Bacteroidetes	976|Bacteroidetes	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_1441449_1	861299.J421_0687	4.5e-58	189.0	COG1834@1|root,COG1834@2|Bacteria,1ZUVY@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Amidinotransferase	-	-	3.5.3.18	ko:K01482	-	-	-	-	ko00000,ko01000,ko04147	-	-	-	Amidinotransf
k59_332535_1	459349.CLOAM1249	4.49e-05	50.8	COG0457@1|root,COG0659@1|root,COG0457@2|Bacteria,COG0659@2|Bacteria,2NS3S@2323|unclassified Bacteria	2|Bacteria	EG	Protein of unknown function (DUF2723)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2723,NACHT
k59_1333392_1	1499498.EV05_0784	2.79e-28	116.0	COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,1G0IZ@1117|Cyanobacteria,1MKFF@1212|Prochloraceae	1117|Cyanobacteria	S	Belongs to the CinA family	cinA	-	3.5.1.42	ko:K03742	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
k59_1054253_1	1096546.WYO_4800	2.13e-13	72.0	COG0346@1|root,COG0346@2|Bacteria,1RD81@1224|Proteobacteria,2U7VR@28211|Alphaproteobacteria,1JU5U@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase_3
k59_1054262_1	36809.MAB_3646c	1.3e-68	222.0	COG0160@1|root,COG0160@2|Bacteria,2GJNQ@201174|Actinobacteria,233JV@1762|Mycobacteriaceae	201174|Actinobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	lat	-	2.6.1.36	ko:K03918	ko01100,map01100	-	R00457	RC00006,RC00062	ko00000,ko01000,ko01007	-	-	iNJ661.Rv3290c	Aminotran_3
k59_215080_1	656519.Halsa_1932	7.55e-44	150.0	COG0081@1|root,COG0081@2|Bacteria,1TPTS@1239|Firmicutes,247JB@186801|Clostridia,3WAD0@53433|Halanaerobiales	186801|Clostridia	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
k59_1550263_1	926550.CLDAP_29090	6.39e-25	108.0	COG2373@1|root,COG2373@2|Bacteria,2G5XN@200795|Chloroflexi	200795|Chloroflexi	S	PFAM alpha-2-macroglobulin domain protein	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,Big_5,MG1
k59_1441485_1	1033802.SSPSH_000928	5.26e-54	192.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,1RMTF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
k59_1662149_1	1454202.PPBDW_131011___1	3.88e-20	87.8	COG2908@1|root,COG2908@2|Bacteria,1N3U7@1224|Proteobacteria,1RP1X@1236|Gammaproteobacteria,1XSQ8@135623|Vibrionales	135623|Vibrionales	S	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxH	-	3.6.1.54	ko:K03269	ko00540,ko01100,map00540,map01100	M00060	R04549	RC00002	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Metallophos,Metallophos_2
k59_1662149_2	472759.Nhal_0828	2.08e-21	94.7	COG0515@1|root,COG0515@2|Bacteria,1QXK0@1224|Proteobacteria,1T3DE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K11912	ko02025,ko03070,map02025,map03070	-	-	-	ko00000,ko00001,ko01000,ko01001,ko02044	-	-	-	Pkinase,TIR_2
k59_332573_1	1313172.YM304_04550	5.09e-48	170.0	COG2146@1|root,COG2146@2|Bacteria,2GQWS@201174|Actinobacteria	201174|Actinobacteria	P	Rieske [2Fe-2S] domain	-	-	-	ko:K15762	ko00623,ko00920,ko01100,ko01120,ko01220,map00623,map00920,map01100,map01120,map01220	M00538	R02550,R03562,R05666,R09513	RC00269,RC00490,RC02556	ko00000,ko00001,ko00002	-	-	-	Rieske
k59_106692_1	1304866.K413DRAFT_0723	7.04e-53	177.0	COG3959@1|root,COG3959@2|Bacteria,1TT51@1239|Firmicutes,247IK@186801|Clostridia,36DP2@31979|Clostridiaceae	186801|Clostridia	G	Transketolase	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
k59_332582_1	240015.ACP_0184	4.21e-32	129.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,3Y3HX@57723|Acidobacteria,2JHJ9@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_11,TPR_16,TPR_2,TPR_8
k59_1333443_1	1163408.UU9_10207	1.4e-49	175.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,1X36S@135614|Xanthomonadales	135614|Xanthomonadales	NU	General secretion pathway protein	xpsE	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
k59_551041_2	1499967.BAYZ01000116_gene3145	1.96e-15	75.1	COG1075@1|root,COG1075@2|Bacteria	2|Bacteria	KLT	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	ko:K07002	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
k59_1499295_1	1267535.KB906767_gene5326	7.85e-125	367.0	COG2010@1|root,COG2010@2|Bacteria,3Y650@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Cytochrome_CBB3,Paired_CXXCH_1
k59_832276_2	1265505.ATUG01000001_gene4512	9.34e-66	213.0	COG0462@1|root,COG0462@2|Bacteria,1R2XV@1224|Proteobacteria,42MD5@68525|delta/epsilon subdivisions,2WK1E@28221|Deltaproteobacteria,2MHPM@213118|Desulfobacterales	28221|Deltaproteobacteria	EF	Phosphoribosyl synthetase-associated domain	-	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
k59_1610640_1	338963.Pcar_2201	1.58e-82	258.0	COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,42MMP@68525|delta/epsilon subdivisions,2WK50@28221|Deltaproteobacteria,43T1G@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	UDP-N-acetylmuramate-L-alanine ligase activity	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_1664051_1	1384056.N787_01985	7.23e-47	169.0	2DNHZ@1|root,32XM8@2|Bacteria,1QUVC@1224|Proteobacteria,1T3US@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_108649_1	632292.Calhy_0499	2.78e-16	79.0	COG1414@1|root,COG1414@2|Bacteria,1TRMW@1239|Firmicutes,24BQA@186801|Clostridia,42G3H@68295|Thermoanaerobacterales	186801|Clostridia	K	Transcriptional regulator IclR	-	-	-	ko:K13641	-	-	-	-	ko00000,ko03000	-	-	-	HTH_IclR,IclR
k59_1610665_1	331678.Cphamn1_0956	1.76e-43	158.0	COG5433@1|root,COG5433@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k59_832310_1	1172185.KB911525_gene4034	0.00023	46.6	COG0642@1|root,COG2205@2|Bacteria,2GJKC@201174|Actinobacteria,4FU59@85025|Nocardiaceae	201174|Actinobacteria	T	Domain of unknown function (DUF4118)	kdpD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0044424,GO:0044464,GO:0071944	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,HATPase_c,HisKA,KdpD,Usp
k59_832310_2	1125863.JAFN01000001_gene3058	1.3e-20	94.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WKFA@28221|Deltaproteobacteria	68525|delta/epsilon subdivisions	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_889511_1	1280953.HOC_18124	3.61e-88	277.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,2TU21@28211|Alphaproteobacteria,43Z43@69657|Hyphomonadaceae	28211|Alphaproteobacteria	C	pyruvate flavodoxin ferredoxin oxidoreductase	MA20_01045	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
k59_1110991_1	1121943.KB899990_gene3688	3.09e-33	128.0	2DC1M@1|root,2ZCGD@2|Bacteria,1RC49@1224|Proteobacteria	1224|Proteobacteria	S	Alginate lyase	-	-	4.2.2.3	ko:K01729	ko00051,map00051	-	R03706	-	ko00000,ko00001,ko01000	-	-	-	Alginate_lyase
k59_1110991_2	1121943.KB899990_gene3690	1.05e-24	100.0	2DBVG@1|root,2ZBB1@2|Bacteria,1N1MS@1224|Proteobacteria,1SCGP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1552218_1	765420.OSCT_0769	1.03e-37	142.0	COG5295@1|root,COG5295@2|Bacteria,2GB82@200795|Chloroflexi,377IZ@32061|Chloroflexia	32061|Chloroflexia	UW	Hep Hag repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Pectinesterase
k59_662898_1	1122180.Lokhon_00838	1.5e-55	181.0	COG0164@1|root,COG0164@2|Bacteria,1RA65@1224|Proteobacteria,2U73X@28211|Alphaproteobacteria,2P8FC@245186|Loktanella	28211|Alphaproteobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
k59_774815_1	1229780.BN381_420007	2.5e-82	264.0	COG0556@1|root,COG0556@2|Bacteria,2GJ03@201174|Actinobacteria,3UWC3@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	GO:0002682,GO:0002684,GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0008150,GO:0009605,GO:0009607,GO:0016020,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0044464,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0071944,GO:0075136	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
k59_774819_1	502025.Hoch_5610	2.92e-38	139.0	COG2267@1|root,COG2267@2|Bacteria,1QUFU@1224|Proteobacteria,43BQ1@68525|delta/epsilon subdivisions,2X718@28221|Deltaproteobacteria,2Z3MK@29|Myxococcales	28221|Deltaproteobacteria	I	alpha/beta hydrolase fold	menH	-	4.2.99.20	ko:K08680	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R08166	RC02148,RC02475	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_6
k59_273570_1	247490.KSU1_C1324	5.14e-18	85.5	COG1957@1|root,COG3055@1|root,COG3204@1|root,COG4932@1|root,COG1957@2|Bacteria,COG3055@2|Bacteria,COG3204@2|Bacteria,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	-	ko:K02674,ko:K07004	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	DUF547,Laminin_G_3,Malectin
k59_998922_1	1089553.Tph_c18060	2.77e-33	124.0	COG0237@1|root,COG0237@2|Bacteria,1V6FS@1239|Firmicutes,24GFQ@186801|Clostridia,42G1K@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	-	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE
k59_662920_1	1123024.AUII01000012_gene4198	0.000231	48.1	COG1652@1|root,COG1652@2|Bacteria,2GK68@201174|Actinobacteria,4EF8H@85010|Pseudonocardiales	201174|Actinobacteria	S	Lysin motif	-	-	-	-	-	-	-	-	-	-	-	-	LysM,Transglycosylas
k59_164930_1	1229909.NSED_07650	3.31e-48	157.0	COG0832@1|root,arCOG04527@2157|Archaea,41T4P@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Urease beta subunit	-	-	3.5.1.5	ko:K01429	ko00220,ko00230,ko00791,ko01100,ko01120,map00220,map00230,map00791,map01100,map01120	-	R00131	RC02798,RC02806	ko00000,ko00001,ko01000	-	-	-	Urease_beta
k59_164930_2	1459636.NTE_02912	1.17e-07	49.7	COG0831@1|root,arCOG04528@2157|Archaea,41SPI@651137|Thaumarchaeota	651137|Thaumarchaeota	E	(urease) gamma subunit	-	-	3.5.1.5	ko:K01430	ko00220,ko00230,ko00791,ko01100,ko01120,map00220,map00230,map00791,map01100,map01120	-	R00131	RC02798,RC02806	ko00000,ko00001,ko01000	-	-	-	Urease_gamma
k59_998949_1	1038859.AXAU01000002_gene562	1.92e-14	77.0	COG0725@1|root,COG0725@2|Bacteria,1PA2T@1224|Proteobacteria,2U1JI@28211|Alphaproteobacteria,3JUZJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	5.3.3.7	ko:K02020,ko:K22003	ko00660,ko02010,map00660,map02010	M00189	R02244	RC00668	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	SBP_bac_11
k59_217072_1	351607.Acel_1033	4.95e-33	120.0	COG4747@1|root,COG4747@2|Bacteria	2|Bacteria	-	-	hom	-	1.1.1.3,1.1.1.399,1.1.1.95,4.3.1.19	ko:K00003,ko:K00058,ko:K01754,ko:K04767	ko00260,ko00270,ko00290,ko00300,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00290,map00300,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00017,M00018,M00020,M00570	R00220,R00996,R01513,R01773,R01775	RC00031,RC00087,RC00418,RC02600	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT,CBS,Homoserine_dh,Lactamase_B,NAD_binding_3
k59_662959_1	351348.Maqu_0982	3.83e-57	196.0	COG3666@1|root,COG3666@2|Bacteria,1QW5T@1224|Proteobacteria,1T44C@1236|Gammaproteobacteria,46D6Z@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_52853_1	358220.C380_17375	3.66e-47	163.0	COG0559@1|root,COG0559@2|Bacteria,1N5XH@1224|Proteobacteria,2VHAJ@28216|Betaproteobacteria,4AB5H@80864|Comamonadaceae	28216|Betaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_387449_1	314230.DSM3645_26714	3.58e-89	273.0	COG0714@1|root,COG0714@2|Bacteria,2IX8Y@203682|Planctomycetes	203682|Planctomycetes	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
k59_1111109_1	1336208.JADY01000004_gene3775	1.71e-13	75.5	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,2JVGM@204441|Rhodospirillales	204441|Rhodospirillales	T	Cache domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg,dCache_1
k59_998961_1	565034.BHWA1_00678	1.68e-62	203.0	COG0451@1|root,COG0451@2|Bacteria	2|Bacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	hldD	GO:0000166,GO:0000271,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008712,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016853,GO:0016854,GO:0016857,GO:0033692,GO:0034637,GO:0034645,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0048037,GO:0050661,GO:0050662,GO:0070401,GO:0071704,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901576,GO:1903509	5.1.3.20	ko:K03274	ko00540,ko01100,map00540,map01100	M00064	R05176	RC01291	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	iPC815.YPO0058,iYL1228.KPN_03963	Epimerase
k59_998961_2	756272.Plabr_1591	4.65e-14	72.0	COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,2IY6V@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	hldE	-	2.7.1.167,2.7.7.70	ko:K03272	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_like,PfkB
k59_387460_2	1123355.JHYO01000007_gene439	3.86e-55	184.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2TR8H@28211|Alphaproteobacteria,36XMA@31993|Methylocystaceae	28211|Alphaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	lpdA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_164997_1	1380358.JADJ01000005_gene2754	7.09e-17	82.4	COG2271@1|root,COG2271@2|Bacteria,1NBE0@1224|Proteobacteria,1SKSR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_217112_1	1500257.JQNM01000006_gene2115	1.08e-51	181.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4B9BA@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,TPR_16,TPR_19,TPR_8,Trans_reg_C
k59_1777347_1	497964.CfE428DRAFT_2340	6.93e-58	199.0	COG0012@1|root,COG0012@2|Bacteria,46UY8@74201|Verrucomicrobia	74201|Verrucomicrobia	J	GTP binding	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_165027_1	1007096.BAGW01000013_gene2593	1.06e-13	77.0	COG1206@1|root,COG1206@2|Bacteria,1TRKH@1239|Firmicutes,249ZZ@186801|Clostridia,2N8AZ@216572|Oscillospiraceae	186801|Clostridia	J	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GIDA
k59_1111193_1	316274.Haur_4913	2.73e-86	266.0	COG0050@1|root,COG0050@2|Bacteria,2G5KI@200795|Chloroflexi,37531@32061|Chloroflexia	32061|Chloroflexia	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
k59_52931_1	1184267.A11Q_1636	1.71e-51	175.0	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,42KZM@68525|delta/epsilon subdivisions,2MSQ1@213481|Bdellovibrionales,2WJGP@28221|Deltaproteobacteria	213481|Bdellovibrionales	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
k59_663052_1	666509.RCA23_c04280	2.33e-35	130.0	COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,2TQMD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	GM	3-beta hydroxysteroid dehydrogenase	MA20_24380	-	1.6.5.3,1.6.99.3	ko:K00329,ko:K00356	ko00190,map00190	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	3Beta_HSD,Epimerase,NAD_binding_10,RmlD_sub_bind
k59_774967_1	319224.Sputcn32_2225	4.33e-05	49.3	COG2935@1|root,COG2935@2|Bacteria,1MW62@1224|Proteobacteria,1RYD7@1236|Gammaproteobacteria,2QA8Z@267890|Shewanellaceae	1236|Gammaproteobacteria	O	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate	ate	GO:0003674,GO:0003824,GO:0004057,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006508,GO:0006511,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016598,GO:0016740,GO:0016746,GO:0016755,GO:0019538,GO:0019941,GO:0030163,GO:0036211,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575	2.3.2.29	ko:K21420	-	-	R11547,R11548	RC00064	ko00000,ko01000	-	-	-	ATE_C,ATE_N
k59_832547_1	1125973.JNLC01000011_gene603	6.87e-70	228.0	COG2079@1|root,COG2079@2|Bacteria,1MUIG@1224|Proteobacteria,2TU37@28211|Alphaproteobacteria,3JUMM@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	MmgE/PrpD family	prpD	-	4.2.1.79	ko:K01720	ko00640,map00640	-	R04424	RC01152	ko00000,ko00001,ko01000	-	-	-	MmgE_PrpD
k59_1220122_1	861299.J421_2535	5.49e-20	94.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_217178_2	46429.BV95_04316	3.14e-47	161.0	COG0208@1|root,COG0208@2|Bacteria,1MWUS@1224|Proteobacteria,2TS3X@28211|Alphaproteobacteria,2K1H7@204457|Sphingomonadales	204457|Sphingomonadales	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	nrdB	-	1.17.4.1	ko:K00526	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_sm
k59_663080_1	913325.N799_12975	1.57e-37	143.0	COG3387@1|root,COG3387@2|Bacteria,1MV08@1224|Proteobacteria,1RS4U@1236|Gammaproteobacteria,1X54W@135614|Xanthomonadales	135614|Xanthomonadales	G	glycosyl hydrolases	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_15
k59_443336_1	452637.Oter_1897	1.83e-23	106.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_443336_2	485913.Krac_5098	1.1e-16	75.9	COG1695@1|root,COG1695@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	-	-	-	-	-	-	-	-	-	PadR
k59_1111228_1	313628.LNTAR_12046	3.65e-66	220.0	COG3533@1|root,COG3533@2|Bacteria	2|Bacteria	S	Beta-L-arabinofuranosidase, GH127	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_127
k59_1610919_1	765914.ThisiDRAFT_0481	1.78e-24	106.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,1RN03@1236|Gammaproteobacteria,1WXK8@135613|Chromatiales	135613|Chromatiales	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_663089_2	1489678.RDMS_11110	3.66e-21	93.6	COG1926@1|root,COG1926@2|Bacteria,1WKAM@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Phosphoribosyl transferase domain	-	-	-	ko:K07100	-	-	-	-	ko00000	-	-	-	Pribosyltran
k59_273742_1	1134445.AJJM01000006_gene3316	5.69e-07	53.5	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,2GKAX@201174|Actinobacteria	201174|Actinobacteria	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
k59_273742_2	1035195.HMPREF9997_01070	1.92e-12	66.2	COG0307@1|root,COG0307@2|Bacteria,2GKC5@201174|Actinobacteria,22M8W@1653|Corynebacteriaceae	201174|Actinobacteria	H	Riboflavin synthase	ribE	GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
k59_663090_1	314345.SPV1_11936	6.67e-40	137.0	COG5156@1|root,COG5156@2|Bacteria,1N53Q@1224|Proteobacteria	1224|Proteobacteria	DO	anaphase-promoting complex-dependent catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C
k59_663090_2	330214.NIDE3598	7.32e-86	261.0	COG0702@1|root,COG0702@2|Bacteria	2|Bacteria	GM	epimerase	-	-	-	-	-	-	-	-	-	-	-	-	NmrA
k59_1111257_1	1128421.JAGA01000003_gene2937	3.88e-82	256.0	COG0476@1|root,COG0476@2|Bacteria,2NPX3@2323|unclassified Bacteria	2|Bacteria	H	ThiF family	moeB	-	2.7.7.73,2.7.7.80,2.8.1.11	ko:K03148,ko:K21029,ko:K21147	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	Rhodanese,ThiF
k59_1552453_1	754476.Q7A_248	5.17e-89	276.0	COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,1RPMB@1236|Gammaproteobacteria,461TR@72273|Thiotrichales	72273|Thiotrichales	S	Lysin motif	-	-	-	-	-	-	-	-	-	-	-	-	LysM
k59_1220160_1	1397527.Q670_11005	1.95e-82	267.0	COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RN01@1236|Gammaproteobacteria,1XIAS@135619|Oceanospirillales	135619|Oceanospirillales	S	of the RND superfamily	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
k59_443382_1	1313172.YM304_33000	1.77e-16	79.7	COG0560@1|root,COG0560@2|Bacteria,2GJVX@201174|Actinobacteria,4CN1K@84992|Acidimicrobiia	84992|Acidimicrobiia	E	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
k59_273771_1	395493.BegalDRAFT_2108	1.59e-06	48.5	COG0799@1|root,COG0799@2|Bacteria,1MZEF@1224|Proteobacteria,1S8W3@1236|Gammaproteobacteria,46197@72273|Thiotrichales	72273|Thiotrichales	J	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
k59_273771_2	105559.Nwat_0455	1.27e-34	127.0	COG1057@1|root,COG1057@2|Bacteria,1RD0J@1224|Proteobacteria,1RP00@1236|Gammaproteobacteria,1WY6R@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
k59_217225_1	234267.Acid_7231	8.83e-117	359.0	COG3533@1|root,COG3533@2|Bacteria,3Y6B7@57723|Acidobacteria	57723|Acidobacteria	S	Beta-L-arabinofuranosidase, GH127	-	-	-	ko:K09955	-	-	-	-	ko00000	-	-	-	Glyco_hydro_127
k59_387609_1	342949.PNA2_1875	1.07e-12	72.8	COG1301@1|root,arCOG04335@2157|Archaea,2XTU7@28890|Euryarchaeota,243FD@183968|Thermococci	183968|Thermococci	C	Sodium:dicarboxylate symporter family	-	GO:0001504,GO:0001505,GO:0003333,GO:0003674,GO:0005215,GO:0005283,GO:0005310,GO:0005326,GO:0005342,GO:0005343,GO:0005416,GO:0005488,GO:0005515,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0006820,GO:0006821,GO:0006835,GO:0006836,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0009987,GO:0015075,GO:0015077,GO:0015081,GO:0015103,GO:0015108,GO:0015171,GO:0015172,GO:0015179,GO:0015183,GO:0015291,GO:0015293,GO:0015294,GO:0015318,GO:0015370,GO:0015556,GO:0015672,GO:0015698,GO:0015711,GO:0015740,GO:0015800,GO:0015807,GO:0015849,GO:0016043,GO:0022607,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0035725,GO:0042802,GO:0043090,GO:0043933,GO:0044085,GO:0046873,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0055085,GO:0065003,GO:0065007,GO:0065008,GO:0070206,GO:0070207,GO:0070778,GO:0071702,GO:0071705,GO:0071840,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098660,GO:0098661,GO:0098662,GO:0098739,GO:0140009,GO:1902475,GO:1902476,GO:1903825,GO:1905039	-	-	-	-	-	-	-	-	-	-	SDF
k59_1123719_1	1382306.JNIM01000001_gene1025	2.47e-67	218.0	COG1541@1|root,COG1541@2|Bacteria,2G695@200795|Chloroflexi	200795|Chloroflexi	H	AMP-binding enzyme	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
k59_1401089_1	1167006.UWK_01080	5.96e-48	166.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,42NQP@68525|delta/epsilon subdivisions,2WIQD@28221|Deltaproteobacteria,2MJGP@213118|Desulfobacterales	28221|Deltaproteobacteria	BQ	PFAM Histone deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
k59_789805_1	46429.BV95_01866	0.000598	44.3	COG2079@1|root,COG2079@2|Bacteria,1MX2N@1224|Proteobacteria,2U4FG@28211|Alphaproteobacteria,2K314@204457|Sphingomonadales	204457|Sphingomonadales	S	MmgE/PrpD family	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
k59_789805_2	1208323.B30_17495	0.000543	44.7	COG3181@1|root,COG3181@2|Bacteria,1N8DG@1224|Proteobacteria,2UH3P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_289398_1	330214.NIDE0045	5.09e-16	75.1	COG0546@1|root,COG0546@2|Bacteria	2|Bacteria	S	glycolate biosynthetic process	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
k59_11435_1	926569.ANT_10310	1.33e-127	370.0	COG0202@1|root,COG0202@2|Bacteria,2G5M9@200795|Chloroflexi	200795|Chloroflexi	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	GO:0003674,GO:0003824,GO:0003899,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
k59_1289837_2	1121405.dsmv_2759	2.65e-27	108.0	COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,42NJE@68525|delta/epsilon subdivisions,2WKMA@28221|Deltaproteobacteria,2MIAI@213118|Desulfobacterales	28221|Deltaproteobacteria	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
k59_789832_1	1283300.ATXB01000001_gene1586	1.03e-83	269.0	COG0651@1|root,COG0651@2|Bacteria,1MXRW@1224|Proteobacteria,1RM9Q@1236|Gammaproteobacteria,1XDSI@135618|Methylococcales	135618|Methylococcales	C	Proton-conducting membrane transporter	-	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M
k59_233855_1	671143.DAMO_3131	1.38e-97	292.0	COG1077@1|root,COG1077@2|Bacteria,2NNVU@2323|unclassified Bacteria	2|Bacteria	D	MreB/Mbl protein	mreB	GO:0000003,GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005856,GO:0005886,GO:0007049,GO:0008150,GO:0008360,GO:0009987,GO:0016020,GO:0019954,GO:0022402,GO:0022414,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0032505,GO:0042802,GO:0043093,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051301,GO:0051302,GO:0051782,GO:0051983,GO:0065007,GO:0065008,GO:0071944	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
k59_901334_1	479434.Sthe_3381	4.51e-09	55.8	COG3462@1|root,COG3462@2|Bacteria,2GA28@200795|Chloroflexi,27YR9@189775|Thermomicrobia	189775|Thermomicrobia	S	Short C-terminal domain	-	-	-	ko:K08982	-	-	-	-	ko00000	-	-	-	SHOCT
k59_901334_2	246194.CHY_2428	0.000223	42.7	COG3462@1|root,COG3462@2|Bacteria	2|Bacteria	S	membrane protein (DUF2078)	-	-	-	ko:K08982	-	-	-	-	ko00000	-	-	-	SHOCT
k59_1734544_1	237727.NAP1_02885	5.26e-49	174.0	COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,2TRVJ@28211|Alphaproteobacteria,2JZUZ@204457|Sphingomonadales	204457|Sphingomonadales	P	Transport of potassium into the cell	kup	-	-	ko:K03549	-	-	-	-	ko00000,ko02000	2.A.72	-	-	K_trans
k59_236012_1	448385.sce5490	5.68e-35	137.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,42M2A@68525|delta/epsilon subdivisions,2WJ41@28221|Deltaproteobacteria,2YUJJ@29|Myxococcales	28221|Deltaproteobacteria	S	ABC transporter, ATP-binding protein	ybiT	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
k59_624587_1	234267.Acid_1428	2.48e-29	121.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria	57723|Acidobacteria	KLTU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
k59_346566_1	926692.AZYG01000040_gene1506	3.66e-10	60.1	COG0517@1|root,COG0517@2|Bacteria,1VA1X@1239|Firmicutes,24MNT@186801|Clostridia	186801|Clostridia	EGP	PFAM CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_346566_2	234267.Acid_0781	2.03e-14	74.7	COG0697@1|root,COG0697@2|Bacteria,3Y4XS@57723|Acidobacteria	57723|Acidobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_792058_1	309801.trd_A0454	1e-58	197.0	COG0843@1|root,COG0843@2|Bacteria	2|Bacteria	C	heme-copper terminal oxidase activity	coxA2	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_1514438_1	99598.Cal7507_1292	1.36e-93	283.0	COG0667@1|root,COG0667@2|Bacteria,1G3WV@1117|Cyanobacteria,1HTYB@1161|Nostocales	1117|Cyanobacteria	C	Aldo/keto reductase family	-	-	1.1.1.91	ko:K05882	-	-	-	-	ko00000,ko01000	-	-	-	Aldo_ket_red
k59_958460_2	1399115.U719_02165	3.27e-24	101.0	COG0428@1|root,COG0428@2|Bacteria,1TP7J@1239|Firmicutes,4HB3R@91061|Bacilli	91061|Bacilli	P	Mediates zinc uptake. May also transport other divalent cations	XK27_05385	-	-	ko:K07238	-	-	-	-	ko00000,ko02000	2.A.5.5	-	-	Zip
k59_792070_1	316274.Haur_2248	4.28e-20	84.3	COG2154@1|root,COG2154@2|Bacteria,2G7GN@200795|Chloroflexi,375ZK@32061|Chloroflexia	32061|Chloroflexia	H	PFAM transcriptional coactivator pterin dehydratase	-	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
k59_1291931_1	1121033.AUCF01000003_gene3110	3.11e-74	253.0	COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,2TS89@28211|Alphaproteobacteria,2JPCA@204441|Rhodospirillales	204441|Rhodospirillales	E	NAD-specific glutamate dehydrogenase	gdhA	-	1.4.1.2	ko:K15371	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	-	R00243	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	Bac_GDH
k59_346584_1	1121428.DESHY_10106___1	1.69e-12	68.2	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1TPYV@1239|Firmicutes,248JB@186801|Clostridia,2606J@186807|Peptococcaceae	186801|Clostridia	E	homocysteine S-methyltransferase	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_346584_2	589924.Ferp_1793	8.78e-81	248.0	COG2057@1|root,arCOG05316@2157|Archaea,2XW2C@28890|Euryarchaeota,246AI@183980|Archaeoglobi	183980|Archaeoglobi	I	Coenzyme A transferase	-	-	2.8.3.12	ko:K01040	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
k59_1291932_1	1051985.l11_20790	3.65e-06	54.3	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,2VJ86@28216|Betaproteobacteria,2KPGD@206351|Neisseriales	206351|Neisseriales	M	Belongs to the peptidase S41A family	prc	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_S41
k59_291671_1	400682.PAC_15724073	1.57e-21	92.0	KOG4059@1|root,KOG4059@2759|Eukaryota,3A621@33154|Opisthokonta,3BSXB@33208|Metazoa	33208|Metazoa	S	gamma-glutamylcyclotransferase activity	-	GO:0002376,GO:0003674,GO:0003824,GO:0003839,GO:0006950,GO:0006952,GO:0006955,GO:0006959,GO:0007599,GO:0008150,GO:0009611,GO:0016829,GO:0016840,GO:0016842,GO:0032501,GO:0042060,GO:0042381,GO:0045087,GO:0050817,GO:0050878,GO:0050896,GO:0065007,GO:0065008	4.3.2.9	ko:K00682	ko00480,map00480	-	R02743,R03749	RC00064,RC00777	ko00000,ko00001,ko01000	-	-	-	AIG2_2
k59_13614_1	861299.J421_2985	8.42e-31	117.0	COG1974@1|root,COG1974@2|Bacteria	2|Bacteria	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	HTH_3,LexA_DNA_bind,Peptidase_S24
k59_1681190_1	990285.RGCCGE502_09860	3.03e-20	87.4	COG1314@1|root,COG1314@2|Bacteria,1N8MF@1224|Proteobacteria,2UCIP@28211|Alphaproteobacteria,4BE1Y@82115|Rhizobiaceae	28211|Alphaproteobacteria	U	Preprotein translocase subunit SecG	secG	-	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
k59_1681190_2	1380394.JADL01000005_gene5500	2.11e-59	197.0	COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,2TS4Y@28211|Alphaproteobacteria,2JPWM@204441|Rhodospirillales	204441|Rhodospirillales	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
k59_1514465_1	556269.ACDQ01000002_gene1069	1.41e-53	189.0	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,2VIDE@28216|Betaproteobacteria,47338@75682|Oxalobacteraceae	28216|Betaproteobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
k59_1180952_1	314285.KT71_03277	1.94e-90	293.0	COG4447@1|root,COG4447@2|Bacteria,1MVIT@1224|Proteobacteria,1SM0B@1236|Gammaproteobacteria,1J7TW@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Sortilin, neurotensin receptor 3,	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_903579_1	118166.JH976537_gene3963	1.21e-23	101.0	COG3044@1|root,COG3044@2|Bacteria,1G21U@1117|Cyanobacteria,1H8FT@1150|Oscillatoriales	1117|Cyanobacteria	S	ATPase of the ABC class	-	-	-	-	-	-	-	-	-	-	-	-	ABC_ATPase
k59_846888_2	1267535.KB906767_gene4240	2.17e-21	100.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,3Y2HR@57723|Acidobacteria,2JI02@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Tetratricopeptide repeats	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,Trans_reg_C
k59_1736734_1	479434.Sthe_2301	8.45e-28	115.0	COG1316@1|root,COG1316@2|Bacteria,2G6PZ@200795|Chloroflexi,27XRZ@189775|Thermomicrobia	189775|Thermomicrobia	K	cell envelope-related transcriptional attenuator	-	-	-	-	-	-	-	-	-	-	-	-	LytR_C,LytR_cpsA_psr
k59_1403351_1	305900.GV64_04155	5.46e-28	113.0	COG0671@1|root,COG0671@2|Bacteria	2|Bacteria	I	phosphatidate phosphatase activity	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
k59_124168_1	1379270.AUXF01000001_gene2787	2.13e-09	60.1	COG0558@1|root,COG0558@2|Bacteria,1ZTUW@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
k59_1237854_2	1227360.C176_06447	4.1e-38	138.0	COG0159@1|root,COG0159@2|Bacteria,1TPXA@1239|Firmicutes,4HFQ8@91061|Bacilli,26DK3@186818|Planococcaceae	91061|Bacilli	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
k59_903600_1	298654.FraEuI1c_1986	1.71e-15	82.4	COG3653@1|root,COG3653@2|Bacteria	2|Bacteria	Q	N-Acyl-D-aspartate D-glutamate deacylase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_179984_1	1379698.RBG1_1C00001G1886	5.12e-54	186.0	COG1058@1|root,COG1058@2|Bacteria,2NP0G@2323|unclassified Bacteria	2|Bacteria	S	Belongs to the CinA family	cinA	-	3.5.1.42	ko:K03742	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
k59_124179_1	402881.Plav_3299	1.07e-85	281.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2TS2I@28211|Alphaproteobacteria,1JN1R@119043|Rhodobiaceae	28211|Alphaproteobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdJ	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_2_N,Ribonuc_red_lgC
k59_736609_1	272123.Anacy_1299	1.41e-25	107.0	COG0318@1|root,COG3321@1|root,COG4221@1|root,COG0318@2|Bacteria,COG3321@2|Bacteria,COG4221@2|Bacteria,1FZXE@1117|Cyanobacteria,1HJCN@1161|Nostocales	1117|Cyanobacteria	IQ	Acyl transferase domain in polyketide synthase (PKS) enzymes.	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2,AMP-binding,Acyl_transf_1,Aminotran_1_2,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt
k59_1681240_1	1121441.AUCX01000021_gene690	3.34e-11	70.1	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJVV@28221|Deltaproteobacteria,2M817@213115|Desulfovibrionales	28221|Deltaproteobacteria	V	TIGRFAM transporter, hydrophobe amphiphile efflux-1 (HAE1) family	bepE	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_1681242_1	33876.JNXY01000029_gene2662	1.08e-31	119.0	COG1131@1|root,COG1131@2|Bacteria,2GKEH@201174|Actinobacteria,4D8QU@85008|Micromonosporales	201174|Actinobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1681245_2	1380390.JIAT01000009_gene2009	3.34e-11	67.8	COG0031@1|root,COG0031@2|Bacteria,2GIXE@201174|Actinobacteria,4CRTD@84995|Rubrobacteria	84995|Rubrobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	4.2.1.22	ko:K01697	ko00260,ko00270,ko01100,ko01130,ko01230,map00260,map00270,map01100,map01130,map01230	M00035,M00338	R00891,R01290,R04942	RC00056,RC00069,RC00256,RC00489,RC01246	ko00000,ko00001,ko00002,ko01000	-	-	-	CBS,PALP
k59_1014627_1	926569.ANT_14030	4.96e-84	270.0	COG0480@1|root,COG0480@2|Bacteria,2G680@200795|Chloroflexi	200795|Chloroflexi	J	elongation factor Tu domain 2 protein	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_624695_1	1122185.N792_11215	9.23e-37	132.0	COG1028@1|root,COG1028@2|Bacteria,1MUPY@1224|Proteobacteria,1RMCB@1236|Gammaproteobacteria,1X4MA@135614|Xanthomonadales	135614|Xanthomonadales	IQ	Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_624695_2	1123487.KB892857_gene2409	5.41e-28	107.0	COG0463@1|root,COG0463@2|Bacteria,1QTWH@1224|Proteobacteria,2VKU3@28216|Betaproteobacteria,2KUT6@206389|Rhodocyclales	206389|Rhodocyclales	M	Glycosyltransferase like family 2	-	-	-	ko:K00786	-	-	-	-	ko00000,ko01000	-	-	-	Glycos_transf_2
k59_1126061_1	926569.ANT_01680	5.32e-73	236.0	COG3854@1|root,COG3854@2|Bacteria,2G5P5@200795|Chloroflexi	200795|Chloroflexi	S	PFAM single-stranded nucleic acid binding R3H domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_30,R3H
k59_1736802_1	1123024.AUII01000006_gene4634	1.03e-55	181.0	COG3212@1|root,COG3212@2|Bacteria	2|Bacteria	T	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	PepSY
k59_291762_1	1123276.KB893245_gene1725	7.3e-43	154.0	COG1012@1|root,COG1012@2|Bacteria,4NEKG@976|Bacteroidetes,47MQT@768503|Cytophagia	976|Bacteroidetes	C	PFAM Aldehyde dehydrogenase	aldH	-	1.2.1.26	ko:K13877	ko00040,ko00053,map00040,map00053	-	R00264	RC00080	ko00000,ko00001,ko01000	-	-	-	Aldedh
k59_291762_2	344747.PM8797T_20758	2.11e-33	127.0	COG2610@1|root,COG2610@2|Bacteria,2J1TI@203682|Planctomycetes	203682|Planctomycetes	EG	COG2610 H gluconate symporter and related permeases	-	-	-	-	-	-	-	-	-	-	-	-	GntP_permease
k59_1514545_1	671143.DAMO_1380	4.39e-33	122.0	COG0496@1|root,COG0496@2|Bacteria,2NPCG@2323|unclassified Bacteria	2|Bacteria	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	GO:0003674,GO:0003824,GO:0004309,GO:0005488,GO:0005515,GO:0006139,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0008254,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009125,GO:0009129,GO:0009131,GO:0009158,GO:0009161,GO:0009164,GO:0009166,GO:0009173,GO:0009175,GO:0009218,GO:0009222,GO:0009259,GO:0009261,GO:0009987,GO:0016311,GO:0016462,GO:0016787,GO:0016788,GO:0016791,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0030145,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0042578,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046049,GO:0046050,GO:0046131,GO:0046133,GO:0046135,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	iSFxv_1172.SFxv_3035	SurE
k59_1514545_2	1121440.AUMA01000006_gene1425	3.23e-37	133.0	COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,42QSI@68525|delta/epsilon subdivisions,2WMNJ@28221|Deltaproteobacteria,2M7VK@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
k59_1292027_1	766499.C357_22170	1.27e-81	265.0	COG2307@1|root,COG2308@1|root,COG2307@2|Bacteria,COG2308@2|Bacteria,1MX5P@1224|Proteobacteria,2TRJE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Evidence 4 Homologs of previously reported genes of	MA20_16190	-	-	-	-	-	-	-	-	-	-	-	Alpha-E,CP_ATPgrasp_2
k59_402739_1	926569.ANT_06860	2.79e-14	72.8	COG1484@1|root,COG1484@2|Bacteria,2G65F@200795|Chloroflexi	200795|Chloroflexi	L	PFAM IstB domain protein ATP-binding protein	-	-	-	ko:K02315	-	-	-	-	ko00000,ko03032	-	-	-	IstB_IS21
k59_402739_2	926569.ANT_06850	7.71e-39	138.0	COG3935@1|root,COG3935@2|Bacteria,2G6W5@200795|Chloroflexi	200795|Chloroflexi	L	TIGRFAM primosome, DnaD subunit	-	-	-	-	-	-	-	-	-	-	-	-	DnaB_2
k59_903671_1	1333523.L593_05430	8.94e-71	234.0	COG2217@1|root,arCOG01576@2157|Archaea,2XT3T@28890|Euryarchaeota,23S6X@183963|Halobacteria	183963|Halobacteria	P	copper-translocating P-type ATPase	-	-	3.6.3.4	ko:K01533	-	-	R00086	RC00002	ko00000,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase
k59_1459389_1	1057002.KB905370_gene4587	1.42e-11	69.7	COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2V7KJ@28211|Alphaproteobacteria,4BJYD@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
k59_681244_1	861299.J421_4104	3.21e-13	74.7	COG5492@1|root,COG5492@2|Bacteria,1ZUE7@142182|Gemmatimonadetes	142182|Gemmatimonadetes	N	Bacterial Ig-like domain 2	-	-	-	-	-	-	-	-	-	-	-	-	Big_2
k59_903681_1	1462527.CCDM010000001_gene2603	4.39e-09	61.6	COG4126@1|root,COG4126@2|Bacteria,1V0N4@1239|Firmicutes,4HP78@91061|Bacilli	91061|Bacilli	E	Hydantoin racemase	-	-	5.1.99.3	ko:K16841	ko00230,ko01120,map00230,map01120	-	R03925	RC01027	ko00000,ko00001,ko01000	-	-	-	Asp_Glu_race
k59_1181079_1	1144310.PMI07_005308	6.53e-73	242.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria,4BI8C@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_346745_1	926569.ANT_02240	6.55e-29	107.0	COG0858@1|root,COG0858@2|Bacteria,2G73E@200795|Chloroflexi	200795|Chloroflexi	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
k59_1292090_1	402881.Plav_2307	2.56e-31	127.0	COG0457@1|root,COG0457@2|Bacteria,1N0A9@1224|Proteobacteria,2TTMN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_14,TPR_16,TPR_19,TPR_2,TPR_8
k59_402793_1	1125863.JAFN01000001_gene2573	5.78e-39	144.0	COG1283@1|root,COG1283@2|Bacteria,1MXWU@1224|Proteobacteria	1224|Proteobacteria	P	phosphate symporter	nptA	-	-	ko:K14683	-	-	-	-	ko00000,ko02000,ko04147	2.A.58.1	-	-	Na_Pi_cotrans
k59_291844_1	693746.OBV_35100	3.19e-37	135.0	COG0517@1|root,COG0517@2|Bacteria,1TQ4J@1239|Firmicutes,24B68@186801|Clostridia	186801|Clostridia	S	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
k59_291844_2	1121396.KB892913_gene117	1.88e-29	114.0	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,42N7M@68525|delta/epsilon subdivisions,2X5JU@28221|Deltaproteobacteria,2MPFA@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Phage integrase, N-terminal SAM-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
k59_1514627_2	861299.J421_0336	3.31e-12	62.4	COG1695@1|root,COG1695@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	-	-	-	-	-	-	-	-	-	PadR
k59_13797_1	926569.ANT_02680	1.8e-54	184.0	COG0475@1|root,COG0475@2|Bacteria,2G6B0@200795|Chloroflexi	200795|Chloroflexi	P	Sodium hydrogen exchanger	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
k59_1736893_1	471857.Svir_22440	4.25e-46	160.0	COG4301@1|root,COG4301@2|Bacteria,2GJAX@201174|Actinobacteria,4DYPU@85010|Pseudonocardiales	201174|Actinobacteria	S	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine	egtD	-	2.1.1.44	ko:K18911	ko00340,map00340	-	R01169	RC00003,RC02308	ko00000,ko00001,ko01000	-	-	-	Methyltransf_33
k59_584432_1	1313172.YM304_35560	1.77e-60	202.0	COG1008@1|root,COG1008@2|Bacteria,2GKBN@201174|Actinobacteria,4CMUB@84992|Acidimicrobiia	201174|Actinobacteria	C	Protein synonym NADH dehydrogenase I subunit M	nuoM2	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_1308706_1	903818.KI912268_gene1318	6.66e-21	91.7	COG0702@1|root,COG0702@2|Bacteria,3Y7DF@57723|Acidobacteria	57723|Acidobacteria	GM	Protein of unknown function (DUF2867)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2867,NAD_binding_10
k59_1308706_2	909613.UO65_0572	3.95e-28	107.0	COG3476@1|root,COG3476@2|Bacteria,2IQA5@201174|Actinobacteria,4E5Q1@85010|Pseudonocardiales	201174|Actinobacteria	T	TspO/MBR family	-	-	-	ko:K05770	ko04080,ko04214,ko04979,ko05166,map04080,map04214,map04979,map05166	-	-	-	ko00000,ko00001,ko02000	9.A.24	-	-	TspO_MBR
k59_920803_1	287986.DV20_01355	5.18e-06	51.6	COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria,4DYDJ@85010|Pseudonocardiales	201174|Actinobacteria	C	Carbon monoxide	xdhA	-	1.17.1.4	ko:K11177	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_920803_2	1539298.JO41_07595	8.97e-25	98.2	COG2080@1|root,COG2080@2|Bacteria,2J6JG@203691|Spirochaetes	203691|Spirochaetes	C	PFAM 2Fe-2S iron-sulfur cluster binding domain	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
k59_1475224_1	675635.Psed_1541	4.13e-37	142.0	COG4585@1|root,COG4585@2|Bacteria,2GMMU@201174|Actinobacteria,4E675@85010|Pseudonocardiales	201174|Actinobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
k59_861813_1	314225.ELI_02170	5.17e-76	245.0	COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,2TSUQ@28211|Alphaproteobacteria,2K0TH@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
k59_584453_1	1283077.M1HLI2_9CAUD	6.18e-40	150.0	4QC24@10239|Viruses,4QZPR@35237|dsDNA viruses  no RNA stage,4QRZK@28883|Caudovirales,4QP0N@10744|Podoviridae	10744|Podoviridae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1085885_1	1123368.AUIS01000006_gene667	3.14e-65	214.0	COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,1RPJB@1236|Gammaproteobacteria,2NCQ0@225057|Acidithiobacillales	1236|Gammaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_1363832_1	1227739.Hsw_2703	7.47e-14	75.9	COG0702@1|root,COG0702@2|Bacteria,4NFWH@976|Bacteroidetes,47KGG@768503|Cytophagia	976|Bacteroidetes	GM	SusD family	-	-	-	ko:K21572	-	-	-	-	ko00000,ko02000	8.A.46.1,8.A.46.3	-	-	SusD-like_3,SusD_RagB
k59_807590_1	177437.HRM2_10270	5.38e-65	221.0	COG0531@1|root,COG0531@2|Bacteria,1R4IZ@1224|Proteobacteria,42MTQ@68525|delta/epsilon subdivisions,2WK39@28221|Deltaproteobacteria,2MIIG@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease,SLC12
k59_1085887_1	1121877.JQKF01000012_gene330	3.94e-49	165.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
k59_1085887_2	690850.Desaf_2498	9.34e-13	67.0	28KBH@1|root,2Z9YH@2|Bacteria,1R3W2@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1308764_1	1121930.AQXG01000001_gene1225	4.46e-13	75.5	COG1472@1|root,COG1680@1|root,COG1472@2|Bacteria,COG1680@2|Bacteria,4NET8@976|Bacteroidetes	976|Bacteroidetes	G	hydrolase, family 3	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Beta-lactamase,Glyco_hydro_3,Glyco_hydro_3_C
k59_418594_1	469371.Tbis_3127	8.19e-22	99.0	COG1252@1|root,COG1252@2|Bacteria,2GJFE@201174|Actinobacteria,4DXU1@85010|Pseudonocardiales	201174|Actinobacteria	C	NADH dehydrogenase	-	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_1475253_1	1444711.CCJF01000005_gene357	6.15e-32	122.0	2C3WA@1|root,2Z8P1@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4239
k59_920867_1	469617.FUAG_02660	1.26e-70	237.0	COG0188@1|root,COG0188@2|Bacteria,3787P@32066|Fusobacteria	32066|Fusobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_920871_2	436229.JOEH01000006_gene2937	1.32e-18	86.7	COG2114@1|root,COG2197@1|root,COG2114@2|Bacteria,COG2197@2|Bacteria,2GJRI@201174|Actinobacteria	201174|Actinobacteria	T	Adenylyl cyclase class-3 4 guanylyl cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,Response_reg
k59_639905_1	1298867.AUES01000126_gene5138	6.41e-84	261.0	COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,2TS6X@28211|Alphaproteobacteria,3JWIG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Putative transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
k59_639905_2	1229205.BUPH_08508	2.32e-104	313.0	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,2VNSH@28216|Betaproteobacteria,1KGQD@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Phage integrase, N-terminal SAM-like domain	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_4,Phage_integrase
k59_362397_1	1089550.ATTH01000001_gene1667	7.38e-91	288.0	COG0008@1|root,COG0064@1|root,COG0008@2|Bacteria,COG0064@2|Bacteria,4NFCC@976|Bacteroidetes,1FJWI@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	J	tRNA synthetases class I (E and Q), anti-codon binding domain	glnS	-	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
k59_1363873_1	632335.Calkr_2480	3.29e-12	71.6	COG2304@1|root,COG5426@1|root,COG2304@2|Bacteria,COG5426@2|Bacteria,1TQXZ@1239|Firmicutes,249E6@186801|Clostridia,42HW0@68295|Thermoanaerobacterales	186801|Clostridia	S	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	BatA,GATase1_like,VWA,VWA_2,VWA_3
k59_1363880_1	671143.DAMO_0699	2.13e-111	333.0	COG0448@1|root,COG0448@2|Bacteria,2NPBS@2323|unclassified Bacteria	2|Bacteria	G	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2768	NTP_transferase
k59_475854_1	371731.Rsw2DRAFT_1358	8.8e-27	110.0	COG0604@1|root,COG0604@2|Bacteria,1MWBD@1224|Proteobacteria,2TS3Z@28211|Alphaproteobacteria,1FAY5@1060|Rhodobacter	28211|Alphaproteobacteria	C	Zinc-binding dehydrogenase	qor	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_1640406_1	1382306.JNIM01000001_gene1570	2.13e-77	239.0	COG0177@1|root,COG0177@2|Bacteria,2G6A1@200795|Chloroflexi	200795|Chloroflexi	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
k59_307863_1	985867.AEWF01000005_gene2419	2.88e-05	49.3	COG2823@1|root,COG2823@2|Bacteria,1RA8T@1224|Proteobacteria,2U6QG@28211|Alphaproteobacteria,47FTB@766|Rickettsiales	766|Rickettsiales	S	bacterial OsmY and nodulation domain	-	-	-	-	-	-	-	-	-	-	-	-	BON
k59_1586118_2	861299.J421_3007	3.79e-32	112.0	2EQ8R@1|root,33HV0@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1586118_3	861299.J421_3006	1.78e-43	145.0	2E5IJ@1|root,3309Y@2|Bacteria,1ZTU3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_861900_1	883080.HMPREF9697_03197	1.84e-10	65.9	COG3391@1|root,COG3391@2|Bacteria,1MXRF@1224|Proteobacteria,2U1E9@28211|Alphaproteobacteria,3JTTY@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	NHL
k59_1530235_1	570952.ATVH01000013_gene2771	5.44e-103	324.0	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,2TQMY@28211|Alphaproteobacteria,2JQK4@204441|Rhodospirillales	204441|Rhodospirillales	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc
k59_1142027_1	945713.IALB_0462	1.87e-05	52.8	COG0760@1|root,COG0760@2|Bacteria	2|Bacteria	O	peptidyl-prolyl cis-trans isomerase activity	-	-	5.2.1.8	ko:K03769,ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	OmpA,Rotamase,Rotamase_2,Rotamase_3
k59_1586128_1	273063.STK_09680	8.42e-10	64.3	COG1208@1|root,arCOG00663@2157|Archaea,2XPVR@28889|Crenarchaeota	28889|Crenarchaeota	M	PFAM Nucleotidyl transferase	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
k59_1530241_1	203124.Tery_3993	1.58e-13	79.3	COG0004@1|root,COG2114@1|root,COG5002@1|root,COG0004@2|Bacteria,COG2114@2|Bacteria,COG5002@2|Bacteria,1FZXP@1117|Cyanobacteria,1H7QI@1150|Oscillatoriales	1117|Cyanobacteria	T	Belongs to the adenylyl cyclase class-4 guanylyl cyclase family	-	-	4.6.1.1	ko:K01768,ko:K03320	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko02000	1.A.11	-	-	DUF3365,GAF_2,Guanylate_cyc,HNOBA,PAS,PAS_8,PAS_9
k59_807699_1	644282.Deba_1993	3.44e-05	44.7	COG3847@1|root,COG3847@2|Bacteria	2|Bacteria	U	Flp Fap pilin component	pilA	-	-	ko:K02651	ko04112,map04112	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	Class_IIIsignal,Flp_Fap
k59_1142042_1	2074.JNYD01000004_gene4948	1.39e-77	246.0	COG1653@1|root,COG1653@2|Bacteria,2IDWS@201174|Actinobacteria,4E16T@85010|Pseudonocardiales	201174|Actinobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
k59_920961_1	296591.Bpro_2073	7.69e-64	213.0	COG0457@1|root,COG0457@2|Bacteria,1N0A9@1224|Proteobacteria,2VKEE@28216|Betaproteobacteria	28216|Betaproteobacteria	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_975486_1	382464.ABSI01000012_gene2198	3.08e-31	126.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,TPR_11,TPR_16,TPR_7,TPR_8,Trans_reg_C
k59_362487_1	1120949.KB903294_gene3590	6.55e-51	176.0	COG3328@1|root,COG3328@2|Bacteria,2GM8F@201174|Actinobacteria,4D964@85008|Micromonosporales	201174|Actinobacteria	L	Transposase, Mutator family	-	-	-	ko:K07493	-	-	-	-	ko00000	-	-	-	Transposase_mut
k59_1419016_1	1231185.BAMP01000008_gene2181	3.58e-102	308.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,2TSJQ@28211|Alphaproteobacteria,43GRH@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	livM	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2,DUF3382
k59_475941_2	556263.FSEG_01694	2.62e-13	75.1	COG1788@1|root,COG1788@2|Bacteria,379HQ@32066|Fusobacteria	32066|Fusobacteria	I	Coenzyme A transferase	gctA	-	2.8.3.12	ko:K01039	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
k59_1142083_1	379066.GAU_1477	1.97e-52	176.0	COG1493@1|root,COG1493@2|Bacteria,1ZSY3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr)	hprK	-	-	ko:K06023	-	-	-	-	ko00000,ko01000	-	-	-	Hpr_kinase_C,Hpr_kinase_N
k59_861981_1	189753.AXAS01000012_gene4337	1.18e-31	123.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
k59_1308935_1	1244869.H261_01097	0.000171	49.7	COG2206@1|root,COG2206@2|Bacteria,1MW7F@1224|Proteobacteria,2TUGK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	PFAM metal-dependent phosphohydrolase, HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	HD,HD_5
k59_584616_1	379066.GAU_3247	1.32e-75	237.0	2B33H@1|root,31VR5@2|Bacteria,1ZUG1@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1364008_1	767817.Desgi_0723	1.62e-76	266.0	COG2132@1|root,COG2132@2|Bacteria,1V17J@1239|Firmicutes,24FAM@186801|Clostridia,264E3@186807|Peptococcaceae	186801|Clostridia	Q	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	SdrD_B
k59_1530308_1	66373.JOFQ01000012_gene6334	1.39e-31	115.0	COG2030@1|root,COG2030@2|Bacteria,2HFAT@201174|Actinobacteria	201174|Actinobacteria	I	MaoC like domain	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
k59_1364013_1	68194.JNXR01000015_gene7987	9.83e-25	105.0	COG0122@1|root,COG2169@1|root,COG0122@2|Bacteria,COG2169@2|Bacteria,2GITG@201174|Actinobacteria	201174|Actinobacteria	K	helix-turn-helix- domain containing protein, AraC type	alkA	GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003824,GO:0003905,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006304,GO:0006307,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008725,GO:0009987,GO:0016020,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0030312,GO:0032131,GO:0032991,GO:0032993,GO:0033554,GO:0034641,GO:0035510,GO:0043170,GO:0043412,GO:0043733,GO:0043916,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051409,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363	3.2.2.21	ko:K13529	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03000,ko03400	-	-	-	Ada_Zn_binding,AlkA_N,HTH_18,HhH-GPD
k59_1364013_2	911239.CF149_06199	3.97e-14	69.3	COG0350@1|root,COG0350@2|Bacteria,1N2YQ@1224|Proteobacteria,1S68H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	ogt	GO:0003674,GO:0003824,GO:0003908,GO:0006139,GO:0006259,GO:0006281,GO:0006304,GO:0006307,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0009987,GO:0016740,GO:0016741,GO:0032259,GO:0033554,GO:0034641,GO:0035510,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1,Methyltransf_1N
k59_1698293_1	234267.Acid_0690	3.58e-66	224.0	COG1198@1|root,COG1198@2|Bacteria,3Y2NY@57723|Acidobacteria	57723|Acidobacteria	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
k59_1254313_1	765912.Thimo_0150	7.74e-52	180.0	COG0247@1|root,COG0247@2|Bacteria,1NZIG@1224|Proteobacteria,1RYPW@1236|Gammaproteobacteria,1WXQI@135613|Chromatiales	135613|Chromatiales	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_17,Fer4_8
k59_1475420_1	446466.Cfla_3282	1.24e-55	187.0	COG0420@1|root,COG0420@2|Bacteria	2|Bacteria	L	3'-5' exonuclease activity	yhaO	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos,Metallophos_2
k59_1752059_1	1565129.JSFF01000014_gene438	7.81e-25	104.0	COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,1RYRB@1236|Gammaproteobacteria,2QAIB@267890|Shewanellaceae	1236|Gammaproteobacteria	S	PFAM beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_418790_1	1499967.BAYZ01000117_gene3321	3.88e-105	313.0	COG0079@1|root,COG0079@2|Bacteria,2NNZK@2323|unclassified Bacteria	2|Bacteria	E	Aminotransferase class I and II	hisD	-	1.1.1.23,2.6.1.9	ko:K00013,ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R01158,R01163,R03012,R03243	RC00006,RC00099,RC00242,RC00463,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2,Histidinol_dh
k59_975556_1	1382306.JNIM01000001_gene2428	1.51e-74	232.0	COG0022@1|root,COG0022@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	acoB	-	-	ko:K21417	-	-	-	-	ko00000,ko01000	-	-	-	Transket_pyr,Transketolase_C
k59_307991_1	314278.NB231_07652	3.36e-110	325.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,1RP3G@1236|Gammaproteobacteria,1WXRY@135613|Chromatiales	135613|Chromatiales	C	Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase	-	-	1.2.4.1	ko:K00162,ko:K21417	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
k59_196020_1	314278.NB231_11044	6.69e-52	181.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,1RNQM@1236|Gammaproteobacteria,1WWEC@135613|Chromatiales	135613|Chromatiales	S	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis	ubiB	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1
k59_1364036_1	420324.KI911932_gene322	1.03e-20	94.4	COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,1JR57@119045|Methylobacteriaceae	28211|Alphaproteobacteria	T	Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DZR,Guanylate_cyc,SAM_1
k59_476012_1	263358.VAB18032_09325	1.47e-86	260.0	COG0225@1|root,COG0225@2|Bacteria,2GJ1S@201174|Actinobacteria,4DAA5@85008|Micromonosporales	201174|Actinobacteria	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
k59_752095_1	266117.Rxyl_0772	3.42e-75	236.0	COG2129@1|root,COG2129@2|Bacteria,2IJW1@201174|Actinobacteria,4CQ37@84995|Rubrobacteria	84995|Rubrobacteria	S	metallophosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_29533_2	926569.ANT_08670	6.02e-10	60.1	COG1514@1|root,COG1514@2|Bacteria,2G76S@200795|Chloroflexi	200795|Chloroflexi	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	ligT	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
k59_640083_2	861299.J421_1340	3.43e-33	130.0	COG0312@1|root,COG0312@2|Bacteria,1ZSUE@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Putative modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD,TAT_signal
k59_1197204_2	446470.Snas_3569	6.58e-13	66.6	COG1695@1|root,COG1695@2|Bacteria,2IQ8I@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator PadR family protein	-	-	-	-	-	-	-	-	-	-	-	-	PadR
k59_601173_1	1105031.HMPREF1141_1053	2.58e-25	96.3	COG1278@1|root,COG1278@2|Bacteria,1VBBH@1239|Firmicutes,24QK9@186801|Clostridia,36MNT@31979|Clostridiaceae	186801|Clostridia	K	Probable zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	zf-trcl
k59_601173_2	243231.GSU1222	5.19e-13	70.5	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,42MY3@68525|delta/epsilon subdivisions,2WJEF@28221|Deltaproteobacteria,43TQX@69541|Desulfuromonadales	28221|Deltaproteobacteria	BQ	Histone deacetylase domain	-	-	-	ko:K04768	-	-	-	-	ko00000	-	-	-	Hist_deacetyl
k59_157484_1	83219.PM02_17810	4.35e-18	87.8	COG4409@1|root,COG4409@2|Bacteria,1MVUD@1224|Proteobacteria,2TRQQ@28211|Alphaproteobacteria,3ZV8B@60136|Sulfitobacter	28211|Alphaproteobacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2
k59_1545986_1	880073.Calab_1713	7.18e-74	238.0	COG1660@1|root,COG3178@1|root,COG1660@2|Bacteria,COG3178@2|Bacteria,2NP9G@2323|unclassified Bacteria	2|Bacteria	S	P-loop ATPase protein family	-	GO:0000166,GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005975,GO:0006022,GO:0006040,GO:0006082,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009254,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0017076,GO:0019200,GO:0019752,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0046835,GO:0071704,GO:0097159,GO:0097172,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901564	2.7.1.221	ko:K06958,ko:K07102	ko00520,ko01100,map00520,map01100	-	R08968,R11024	RC00002,RC00078	ko00000,ko00001,ko01000,ko03019	-	-	-	APH,ATP_bind_2
k59_326119_1	264462.Bd0135	0.000354	43.9	COG0778@1|root,COG0778@2|Bacteria,1Q5CS@1224|Proteobacteria,42VS3@68525|delta/epsilon subdivisions,2MTT4@213481|Bdellovibrionales,2WSG5@28221|Deltaproteobacteria	213481|Bdellovibrionales	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
k59_1603491_1	1230343.CANP01000024_gene1901	1.91e-14	76.6	COG1196@1|root,COG1196@2|Bacteria,1NDEE@1224|Proteobacteria,1SJIB@1236|Gammaproteobacteria,1JDUW@118969|Legionellales	118969|Legionellales	D	Domain of unknown function (DUF4349)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4349
k59_494064_2	648757.Rvan_2710	7.36e-25	100.0	COG0765@1|root,COG0765@2|Bacteria,1MUVX@1224|Proteobacteria,2TRAT@28211|Alphaproteobacteria,3N8NX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	MA20_06175	-	-	ko:K10003	ko02010,ko02020,map02010,map02020	M00230	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.19,3.A.1.3.4	-	-	BPD_transp_1
k59_1603492_1	1382356.JQMP01000004_gene231	2.83e-81	254.0	COG3552@1|root,COG3552@2|Bacteria,2G5IW@200795|Chloroflexi,27XNE@189775|Thermomicrobia	189775|Thermomicrobia	S	VWA domain containing CoxE-like protein	-	-	-	ko:K07161	-	-	-	-	ko00000	-	-	-	VWA_CoxE
k59_715863_1	1288963.ADIS_4672	6.13e-22	100.0	COG2849@1|root,COG2849@2|Bacteria	2|Bacteria	-	-	-	-	2.4.1.52	ko:K00712	-	-	-	-	ko00000,ko01000,ko01003	-	GT4	-	DUF285,Glycos_transf_1,MORN_2
k59_1546001_1	35754.JNYJ01000017_gene6316	6.65e-28	106.0	COG1764@1|root,COG1764@2|Bacteria,2IFFB@201174|Actinobacteria,4DCYH@85008|Micromonosporales	201174|Actinobacteria	O	OsmC-like protein	osmC	-	-	ko:K04063	-	-	-	-	ko00000	-	-	-	OsmC
k59_1272550_1	288000.BBta_1740	2.29e-82	261.0	COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,2TSTH@28211|Alphaproteobacteria,3JSAY@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	histidyl-tRNA aminoacylation	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
k59_715883_1	463191.SSEG_06736	9.43e-16	76.3	COG0599@1|root,COG0599@2|Bacteria,2GITB@201174|Actinobacteria	201174|Actinobacteria	I	decarboxylase	-	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD
k59_715883_2	395963.Bind_2590	3.57e-08	54.3	COG0642@1|root,COG2205@2|Bacteria,1MUAK@1224|Proteobacteria,2TSUC@28211|Alphaproteobacteria,3NCE6@45404|Beijerinckiaceae	28211|Alphaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
k59_45553_1	866774.HMPREF9248_1075	6.65e-20	90.9	COG0337@1|root,COG0337@2|Bacteria,2GIUZ@201174|Actinobacteria,4CUIE@84998|Coriobacteriia	84998|Coriobacteriia	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	4.2.3.4	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03083	RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
k59_157526_1	1122138.AQUZ01000003_gene580	5.38e-38	142.0	COG1132@1|root,COG1132@2|Bacteria,2GJYK@201174|Actinobacteria,4DT7S@85009|Propionibacteriales	201174|Actinobacteria	V	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
k59_1657456_2	1408813.AYMG01000008_gene3937	3.07e-33	129.0	COG0558@1|root,COG0558@2|Bacteria,4NGNI@976|Bacteroidetes,1INPN@117747|Sphingobacteriia	976|Bacteroidetes	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA1	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf,DUF4833
k59_1493310_2	526227.Mesil_0390	3.4e-47	154.0	COG1694@1|root,COG1694@2|Bacteria,1WK7E@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM MazG nucleotide pyrophosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	MazG
k59_601229_1	333138.LQ50_20100	2.29e-32	118.0	COG3435@1|root,COG3435@2|Bacteria	2|Bacteria	Q	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_601229_2	1120972.AUMH01000002_gene2756	5.29e-14	69.7	2F1RH@1|root,33URM@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Auxin_BP,Cupin_2
k59_102299_1	530564.Psta_3813	3.34e-51	181.0	COG0668@1|root,COG1196@1|root,COG0668@2|Bacteria,COG1196@2|Bacteria,2J2C2@203682|Planctomycetes	203682|Planctomycetes	M	Mechanosensitive ion channel	-	-	-	ko:K03442,ko:K22044	-	-	-	-	ko00000,ko02000	1.A.23.2,1.A.23.3	-	-	MS_channel
k59_1657464_1	313624.NSP_19220	4.39e-40	151.0	COG2132@1|root,COG2132@2|Bacteria,1G2BC@1117|Cyanobacteria,1HNMW@1161|Nostocales	1117|Cyanobacteria	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
k59_1603532_1	1381123.AYOD01000005_gene1210	7.41e-13	69.7	COG2128@1|root,COG2128@2|Bacteria,1RD2I@1224|Proteobacteria,2U7MW@28211|Alphaproteobacteria,43KM1@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
k59_1213920_1	96561.Dole_0563	4.39e-09	56.2	2A4CF@1|root,30SY3@2|Bacteria,1RFXP@1224|Proteobacteria,42RIM@68525|delta/epsilon subdivisions,2WNS6@28221|Deltaproteobacteria,2MNMZ@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Yip1
k59_880231_1	926569.ANT_06840	3.79e-67	218.0	COG0305@1|root,COG0305@2|Bacteria,2G64D@200795|Chloroflexi	200795|Chloroflexi	L	Participates in initiation and elongation during chromosome replication	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
k59_768361_1	247490.KSU1_C1314	8.98e-68	226.0	COG0535@1|root,COG0535@2|Bacteria,2J2KS@203682|Planctomycetes	203682|Planctomycetes	S	Proto-chlorophyllide reductase 57 kD subunit	-	-	-	-	-	-	-	-	-	-	-	-	PCP_red,Radical_SAM,SPASM
k59_1493326_1	926569.ANT_30870	9.55e-63	199.0	COG0586@1|root,COG0586@2|Bacteria,2G79V@200795|Chloroflexi	200795|Chloroflexi	S	SNARE associated Golgi protein	-	-	-	ko:K03975	-	-	-	-	ko00000	-	-	-	SNARE_assoc
k59_655869_1	794846.AJQU01000100_gene5524	1.28e-42	158.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4B9US@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,Trans_reg_C
k59_1049185_1	105559.Nwat_1383	6.92e-55	192.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,1WX97@135613|Chromatiales	135613|Chromatiales	I	Enoyl-CoA hydratase isomerase	-	-	1.1.1.35,4.2.1.17,5.1.2.3	ko:K01782	ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
k59_655876_1	882.DVU_2233	2.62e-14	76.6	COG0429@1|root,COG0429@2|Bacteria,1MWV1@1224|Proteobacteria,42N26@68525|delta/epsilon subdivisions,2WK9Q@28221|Deltaproteobacteria,2M90M@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM Alpha beta hydrolase	-	-	-	ko:K07019	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Hydrolase_4
k59_1436501_1	1423816.BACQ01000037_gene1567	7.31e-11	67.4	COG1228@1|root,COG1228@2|Bacteria,1TQQ0@1239|Firmicutes,4HDKW@91061|Bacilli,3F4D3@33958|Lactobacillaceae	91061|Bacilli	Q	Imidazolonepropionase and related amidohydrolases	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_45604_2	640512.BC1003_4856	4.26e-13	70.9	COG3797@1|root,COG3797@2|Bacteria,1N0SN@1224|Proteobacteria,2VS8Y@28216|Betaproteobacteria,1K7B3@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF1697)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1697
k59_1272620_1	331113.SNE_A09700	7.23e-38	130.0	COG2154@1|root,COG2154@2|Bacteria,2JGH7@204428|Chlamydiae	204428|Chlamydiae	H	Pterin 4 alpha carbinolamine dehydratase	-	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
k59_1436509_1	1163409.UUA_13320	2.77e-13	72.8	COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,1SAP8@1236|Gammaproteobacteria,1X9W4@135614|Xanthomonadales	135614|Xanthomonadales	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_655887_1	1229780.BN381_100014	6.71e-38	141.0	COG0628@1|root,COG0628@2|Bacteria,2GN4Y@201174|Actinobacteria,3UWTJ@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
k59_601266_2	391937.NA2_02814	4.43e-22	94.4	28MZG@1|root,2ZB66@2|Bacteria,1R6ZF@1224|Proteobacteria,2U3DX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
k59_1603573_1	1459636.NTE_01921	2.28e-70	222.0	COG0061@1|root,COG0640@1|root,arCOG00394@2157|Archaea,arCOG01348@2157|Archaea,41SEC@651137|Thaumarchaeota	651137|Thaumarchaeota	HK	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	-	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
k59_267204_1	55529.EKX46552	5.51e-72	231.0	COG0141@1|root,KOG2697@2759|Eukaryota	2759|Eukaryota	E	histidinol dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Histidinol_dh
k59_1657533_1	1174528.JH992890_gene502	2.4e-26	105.0	COG3385@1|root,COG3385@2|Bacteria,1G4GS@1117|Cyanobacteria	1117|Cyanobacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
k59_211094_1	278963.ATWD01000001_gene2100	1.14e-76	238.0	COG0535@1|root,COG0535@2|Bacteria,3Y3TY@57723|Acidobacteria	57723|Acidobacteria	S	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM
k59_435558_1	700598.Niako_5159	2.2e-31	114.0	COG2080@1|root,COG2080@2|Bacteria,4NPTH@976|Bacteroidetes,1IXDG@117747|Sphingobacteriia	976|Bacteroidetes	C	COGs COG2080 Aerobic-type carbon monoxide dehydrogenase small subunit CoxS CutS homologs	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
k59_435558_2	1265310.CCBD010000007_gene2964	3.68e-11	65.1	COG1319@1|root,COG1319@2|Bacteria,2GT14@201174|Actinobacteria,2348W@1762|Mycobacteriaceae	201174|Actinobacteria	C	Dehydrogenase	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	iNJ661.Rv0375c	CO_deh_flav_C,FAD_binding_5
k59_45643_1	330214.NIDE3768	9.18e-90	281.0	COG0296@1|root,COG0296@2|Bacteria,3J0Y2@40117|Nitrospirae	40117|Nitrospirae	G	Alpha amylase, catalytic domain	-	-	2.4.1.18,3.2.1.141	ko:K00700,ko:K01236	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110,R09995,R11256	RC00049	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,CBM_48
k59_435563_1	1123355.JHYO01000008_gene2636	1.43e-22	97.1	COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,2TSEY@28211|Alphaproteobacteria,36X4K@31993|Methylocystaceae	28211|Alphaproteobacteria	M	Glycosyltransferase family 28 N-terminal domain	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
k59_435563_2	1123366.TH3_07532	1.54e-27	109.0	COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,2TQSA@28211|Alphaproteobacteria,2JP9E@204441|Rhodospirillales	204441|Rhodospirillales	D	Belongs to the SEDS family	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
k59_880328_1	926569.ANT_24780	5e-40	139.0	COG0437@1|root,COG0437@2|Bacteria,2G6C1@200795|Chloroflexi	200795|Chloroflexi	C	4Fe-4S dicluster domain	-	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_7
k59_1716026_1	1380356.JNIK01000011_gene1958	4.27e-80	247.0	COG1741@1|root,COG1741@2|Bacteria,2GIY9@201174|Actinobacteria,4ES53@85013|Frankiales	201174|Actinobacteria	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
k59_880351_1	679189.HMPREF9019_1581	0.000119	48.5	COG2801@1|root,COG2801@2|Bacteria,4NM64@976|Bacteroidetes,2G36F@200643|Bacteroidia	976|Bacteroidetes	L	Integrase core domain protein	-	-	-	-	-	-	-	-	-	-	-	-	rve,rve_3
k59_880351_2	102129.Lepto7375DRAFT_7502	6.44e-18	79.3	COG2963@1|root,COG2963@2|Bacteria,1GAKB@1117|Cyanobacteria	1117|Cyanobacteria	L	IMG reference gene	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
k59_1049250_2	1182553.XP_007742101.1	4.68e-32	126.0	COG0044@1|root,KOG2584@2759|Eukaryota,38CFY@33154|Opisthokonta,3NWXN@4751|Fungi,3QJEC@4890|Ascomycota,20AJJ@147545|Eurotiomycetes,3MSMN@451870|Chaetothyriomycetidae	4751|Fungi	F	Allantoinase	DAL1	GO:0000255,GO:0000256,GO:0003674,GO:0003824,GO:0004038,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009442,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0017144,GO:0019439,GO:0034641,GO:0042737,GO:0043603,GO:0043605,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575	3.5.2.5	ko:K01466	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R02425	RC00680	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
k59_1603630_2	243233.MCA1900	5.77e-33	123.0	COG1230@1|root,COG1230@2|Bacteria,1MVQB@1224|Proteobacteria,1RMR8@1236|Gammaproteobacteria,1XF2R@135618|Methylococcales	135618|Methylococcales	P	Cation efflux family	-	-	-	ko:K16264	-	-	-	-	ko00000,ko02000	2.A.4.1	-	-	Cation_efflux
k59_1546140_1	991905.SL003B_3382	1.92e-42	147.0	COG2334@1|root,COG2334@2|Bacteria,1MUKJ@1224|Proteobacteria,2TS6D@28211|Alphaproteobacteria,4BPQ3@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	F	Belongs to the pseudomonas-type ThrB family	thrB	-	2.7.1.39	ko:K02204	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	APH
k59_1546140_2	570967.JMLV01000014_gene2061	8.2e-40	135.0	COG0328@1|root,COG0328@2|Bacteria,1RCZ1@1224|Proteobacteria,2U7C4@28211|Alphaproteobacteria,2JS6U@204441|Rhodospirillales	204441|Rhodospirillales	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhA	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_H
k59_1716036_1	264198.Reut_B4251	9.89e-18	84.7	COG1595@1|root,COG1595@2|Bacteria,1PT8E@1224|Proteobacteria,2W1XX@28216|Betaproteobacteria,1K2WI@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_494247_1	1169152.AXVD01000019_gene835	1.3e-95	291.0	COG0778@1|root,COG0778@2|Bacteria,2H3K6@201174|Actinobacteria	201174|Actinobacteria	C	Putative TM nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
k59_768477_2	35754.JNYJ01000016_gene9301	9.28e-32	127.0	COG0515@1|root,COG2199@1|root,COG3899@1|root,COG4585@1|root,COG0515@2|Bacteria,COG3706@2|Bacteria,COG3899@2|Bacteria,COG4585@2|Bacteria,2IBPU@201174|Actinobacteria,4DAU6@85008|Micromonosporales	201174|Actinobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GAF,GAF_3,GGDEF,Guanylate_cyc,HATPase_c,HisKA_3,Pkinase
k59_880393_1	926569.ANT_09860	1.93e-18	83.2	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	yyaR	-	-	ko:K06889,ko:K19273	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	Acetyltransf_1
k59_880393_2	926569.ANT_09850	3.12e-13	68.2	28RJQ@1|root,2ZDYJ@2|Bacteria,2G9S7@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1546170_1	1547437.LL06_00335	2.03e-54	182.0	COG0715@1|root,COG0715@2|Bacteria,1PKQN@1224|Proteobacteria,2TSRB@28211|Alphaproteobacteria,43IZ4@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	4,5-dihydroxyphthalate decarboxylase	-	-	4.1.1.55	ko:K04102	ko00624,ko01100,ko01120,map00624,map01100,map01120	M00623	R01635,R05375	RC00390	ko00000,ko00001,ko00002,ko01000	-	-	-	NMT1
k59_601345_1	56107.Cylst_1532	3.03e-70	240.0	COG1020@1|root,COG3320@1|root,COG1020@2|Bacteria,COG3320@2|Bacteria,1G0XE@1117|Cyanobacteria,1HKNU@1161|Nostocales	1117|Cyanobacteria	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
k59_1436623_2	523791.Kkor_0868	2.78e-27	102.0	COG0271@1|root,COG0271@2|Bacteria	2|Bacteria	T	Belongs to the BolA IbaG family	bolA	-	-	ko:K05527,ko:K09780	-	-	-	-	ko00000,ko03000	-	-	-	BolA
k59_1657649_1	631362.Thi970DRAFT_01586	0.000334	45.4	COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,1RMAU@1236|Gammaproteobacteria,1WWSM@135613|Chromatiales	135613|Chromatiales	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)	ubiE	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
k59_1160651_1	1459636.NTE_00413	1.09e-83	254.0	COG2243@1|root,arCOG00648@2157|Archaea,41SGJ@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Tetrapyrrole (Corrin/Porphyrin) Methylases	-	-	2.1.1.130,2.1.1.151	ko:K03394	ko00860,ko01100,map00860,map01100	-	R03948,R05808	RC00003,RC01035,RC01662	ko00000,ko00001,ko01000	-	-	-	TP_methylase
k59_655990_1	1206743.BAGM01000083_gene4268	7.55e-78	253.0	COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,2GNII@201174|Actinobacteria,4FV1H@85025|Nocardiaceae	201174|Actinobacteria	C	Dehydrogenase E1 component	-	-	1.2.4.4	ko:K11381	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
k59_494317_1	234267.Acid_7177	6.48e-26	111.0	COG0577@1|root,COG0577@2|Bacteria,3Y402@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_1769124_1	1128421.JAGA01000002_gene1368	4.95e-128	385.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,2NNW4@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses	nadE	GO:0003674,GO:0003824,GO:0003952,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016020,GO:0016874,GO:0016879,GO:0016880,GO:0016884,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.1.5,6.3.5.1	ko:K01916,ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00189,R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
k59_1382042_1	1100720.ALKN01000026_gene1675	3.75e-73	241.0	28JZQ@1|root,2Z9PN@2|Bacteria,1N2WN@1224|Proteobacteria,2VI2S@28216|Betaproteobacteria,4AD2Q@80864|Comamonadaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1606240_1	1121033.AUCF01000008_gene5743	2.82e-45	165.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2TQJS@28211|Alphaproteobacteria,2JPIV@204441|Rhodospirillales	204441|Rhodospirillales	I	COG1960 Acyl-CoA dehydrogenases	-	-	-	ko:K20035	ko00920,map00920	-	R11130	RC03363	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N
k59_383646_2	1122929.KB908216_gene2108	2.25e-74	230.0	COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,2TSUR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
k59_48374_1	944481.JAFP01000001_gene1647	2.34e-90	289.0	COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,42MDI@68525|delta/epsilon subdivisions,2WIVY@28221|Deltaproteobacteria,2M6ZN@213113|Desulfurellales	28221|Deltaproteobacteria	C	Malic enzyme, NAD binding domain	maeB	-	1.1.1.40	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00169,M00172	R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1637	Malic_M,PTA_PTB,malic
k59_658428_1	880072.Desac_1859	7.46e-89	271.0	COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,42MI2@68525|delta/epsilon subdivisions,2WJ5W@28221|Deltaproteobacteria,2MR0A@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2848	Pribosyl_synth,Pribosyltran_N
k59_603502_1	1121405.dsmv_0202	2.15e-14	74.3	COG0565@1|root,COG0565@2|Bacteria,1N47Y@1224|Proteobacteria,42R3K@68525|delta/epsilon subdivisions,2WJNA@28221|Deltaproteobacteria,2MJFV@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA	trmJ	-	2.1.1.200	ko:K02533,ko:K15396	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
k59_731865_1	1161401.ASJA01000001_gene565	3.46e-17	75.9	COG0251@1|root,COG0251@2|Bacteria,1PHJK@1224|Proteobacteria,2V89Y@28211|Alphaproteobacteria,4405J@69657|Hyphomonadaceae	28211|Alphaproteobacteria	J	translation initiation inhibitor, yjgF family	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
k59_731865_2	311424.DhcVS_1093	5.69e-23	92.0	2A4E9@1|root,2ZJRI@2|Bacteria,2GAVU@200795|Chloroflexi,34DG2@301297|Dehalococcoidia	301297|Dehalococcoidia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_231399_1	796620.VIBC2010_11416	1.75e-42	149.0	COG0545@1|root,COG0545@2|Bacteria,1RDA1@1224|Proteobacteria,1RRKU@1236|Gammaproteobacteria,1XSY6@135623|Vibrionales	135623|Vibrionales	M	COG0545 FKBP-type peptidyl-prolyl cis-trans isomerases 1	fkpA	-	5.2.1.8	ko:K03772	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C,FKBP_N
k59_231399_2	1189612.A33Q_4373	2.32e-10	61.6	COG1228@1|root,COG1228@2|Bacteria,4NISN@976|Bacteroidetes,47XBR@768503|Cytophagia	976|Bacteroidetes	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_1565451_1	203122.Sde_1930	2.12e-130	390.0	COG0845@1|root,COG5569@1|root,COG0845@2|Bacteria,COG5569@2|Bacteria,1MVAS@1224|Proteobacteria,1RPBZ@1236|Gammaproteobacteria,464X2@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	cusB	-	-	ko:K07798	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4,8.A.1	-	-	CusF_Ec,HlyD_D23,HlyD_D4
k59_286909_2	398767.Glov_0862	6.5e-18	83.2	COG2048@1|root,COG2048@2|Bacteria,1N37J@1224|Proteobacteria,42P51@68525|delta/epsilon subdivisions,2WK1J@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	heterodisulfide reductase	hdrB	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
k59_9044_2	203122.Sde_1146	1.35e-10	65.1	COG1664@1|root,COG2133@1|root,COG3343@1|root,COG5276@1|root,COG1664@2|Bacteria,COG2133@2|Bacteria,COG3343@2|Bacteria,COG5276@2|Bacteria,1QUZJ@1224|Proteobacteria,1T318@1236|Gammaproteobacteria,46D2K@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	Concanavalin A-like lectin/glucanases superfamily	mshQ	-	-	ko:K12287	-	-	-	-	ko00000,ko02044	-	-	-	Bactofilin,H_lectin,Laminin_G_3,PA14
k59_453833_1	1499967.BAYZ01000069_gene1853	3.39e-95	303.0	COG0474@1|root,COG0474@2|Bacteria,2NNSC@2323|unclassified Bacteria	2|Bacteria	P	Cation transporter/ATPase, N-terminus	pacL	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k59_564489_1	1122135.KB893146_gene1641	2.81e-26	115.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_564491_1	926569.ANT_09690	4.69e-78	243.0	COG1077@1|root,COG1077@2|Bacteria,2G62K@200795|Chloroflexi	200795|Chloroflexi	D	TIGRFAM cell shape determining protein, MreB Mrl family	-	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
k59_1509895_1	861299.J421_6317	6.62e-31	125.0	COG0577@1|root,COG0577@2|Bacteria	861299.J421_6317|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_231438_2	479434.Sthe_0960	1.78e-33	130.0	COG0464@1|root,COG0464@2|Bacteria,2G642@200795|Chloroflexi,27XW8@189775|Thermomicrobia	189775|Thermomicrobia	O	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_620196_1	880073.Calab_3587	6.96e-52	183.0	COG1086@1|root,COG1086@2|Bacteria	2|Bacteria	GM	Polysaccharide biosynthesis protein	-	-	2.7.8.33,2.7.8.35	ko:K02851	-	-	R08856	RC00002	ko00000,ko01000,ko01003,ko01005	-	-	-	Bac_transf,CoA_binding_3,Glycos_transf_4,HTH_45,LicD
k59_1565489_1	631454.N177_0984	6.13e-13	73.6	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,2TT3Z@28211|Alphaproteobacteria,1JNPG@119043|Rhodobiaceae	28211|Alphaproteobacteria	M	Peptidase family M23	MA20_20375	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_564512_1	1163617.SCD_n01217	2.76e-51	165.0	COG3536@1|root,COG3536@2|Bacteria,1MZ5M@1224|Proteobacteria,2VR9K@28216|Betaproteobacteria	28216|Betaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF971
k59_564512_2	571166.KI421509_gene2976	1.42e-09	57.8	COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,2TRWR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)	ubiE	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
k59_509169_1	936455.KI421499_gene2656	3.79e-45	157.0	COG0395@1|root,COG0395@2|Bacteria,1PG6Q@1224|Proteobacteria,2U1HZ@28211|Alphaproteobacteria,3JTY3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Binding-protein-dependent transport system inner membrane component	MA20_13195	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
k59_509169_2	1121861.KB899927_gene1574	1.54e-05	46.2	COG1175@1|root,COG1175@2|Bacteria,1MXKR@1224|Proteobacteria,2TRDJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Binding-protein-dependent transport system inner membrane component	MA20_13200	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
k59_64411_1	1459636.NTE_02002	1.6e-20	84.7	arCOG10524@1|root,arCOG10524@2157|Archaea,41SVP@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1232969_1	290397.Adeh_2304	2.41e-71	237.0	COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,42MYN@68525|delta/epsilon subdivisions,2WIND@28221|Deltaproteobacteria,2YUEV@29|Myxococcales	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.8.5.3,1.8.5.5	ko:K07306,ko:K08352	ko00920,ko01120,map00920,map01120	-	R09501,R10149	RC02555,RC02823	ko00000,ko00001,ko01000,ko02000	5.A.3.3,5.A.3.5	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_1732193_1	1232437.KL661964_gene3327	5.4e-37	140.0	COG0389@1|root,COG1254@1|root,COG0389@2|Bacteria,COG1254@2|Bacteria,1MUUH@1224|Proteobacteria,42NGG@68525|delta/epsilon subdivisions,2WIVT@28221|Deltaproteobacteria,2MHKT@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
k59_342194_1	247490.KSU1_C1302	4.2e-90	282.0	COG0296@1|root,COG0296@2|Bacteria,2IXPW@203682|Planctomycetes	203682|Planctomycetes	G	Alpha amylase, catalytic domain	-	-	3.2.1.1,3.2.1.141	ko:K01176,ko:K01236	ko00500,ko01100,ko01110,ko04973,map00500,map01100,map01110,map04973	M00565	R02108,R02112,R09995,R11256,R11262	RC00049	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48,DUF3459,S6PP
k59_842519_1	1123320.KB889719_gene7367	2.54e-05	48.5	COG2159@1|root,COG2159@2|Bacteria,2GMQY@201174|Actinobacteria	201174|Actinobacteria	S	amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
k59_787338_1	298654.FraEuI1c_2435	9.98e-46	163.0	COG0160@1|root,COG0160@2|Bacteria,2GJNQ@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	lat	-	2.6.1.36	ko:K03918	ko01100,map01100	-	R00457	RC00006,RC00062	ko00000,ko01000,ko01007	-	-	iNJ661.Rv3290c	Aminotran_3
k59_1398737_1	985867.AEWF01000002_gene1659	7.08e-52	176.0	COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,2TRSU@28211|Alphaproteobacteria,47F20@766|Rickettsiales	766|Rickettsiales	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX2	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
k59_9094_1	690850.Desaf_2106	3.9e-34	133.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,42MNF@68525|delta/epsilon subdivisions,2WIYR@28221|Deltaproteobacteria,2M9ZU@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	PFAM Peptidase M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_175578_1	1223410.KN050846_gene134	3.52e-12	66.2	COG2963@1|root,COG2963@2|Bacteria,4NQ8V@976|Bacteroidetes,1I3MZ@117743|Flavobacteriia	976|Bacteroidetes	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
k59_1232998_1	383372.Rcas_2353	1.07e-94	288.0	COG1131@1|root,COG1131@2|Bacteria,2G5YX@200795|Chloroflexi,3762X@32061|Chloroflexia	32061|Chloroflexia	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_175588_1	189425.PGRAT_19655	3.53e-18	88.6	COG2909@1|root,COG2909@2|Bacteria,1UIMV@1239|Firmicutes,4HD7H@91061|Bacilli,26QDM@186822|Paenibacillaceae	91061|Bacilli	K	helix_turn_helix, Lux Regulon	-	-	-	ko:K03556	-	-	-	-	ko00000,ko03000	-	-	-	GerE
k59_1287547_1	1227488.C477_03829	3.06e-57	198.0	COG2217@1|root,arCOG01576@2157|Archaea,2XT3T@28890|Euryarchaeota,23S6X@183963|Halobacteria	183963|Halobacteria	P	copper-translocating P-type ATPase	-	-	3.6.3.4	ko:K01533	-	-	R00086	RC00002	ko00000,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase
k59_231495_1	926569.ANT_29790	1.21e-68	215.0	COG0739@1|root,COG0739@2|Bacteria	2|Bacteria	M	heme binding	-	-	-	ko:K21472	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
k59_453917_1	246195.DNO_1015	3.15e-21	95.1	COG0560@1|root,COG0560@2|Bacteria,1PIND@1224|Proteobacteria,1S9GK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	haloacid dehalogenase-like hydrolase	-	-	3.1.3.3	ko:K01079	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R00582	RC00017	ko00000,ko00001,ko00002,ko01000,ko01009	-	-	-	HAD,Hydrolase
k59_1565546_1	1459636.NTE_00085	3e-74	238.0	COG1311@1|root,arCOG04455@2157|Archaea,41T0D@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polB	-	2.7.7.7	ko:K02323	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	DNA_pol_E_B
k59_1620856_1	1224163.B841_07145	7.61e-39	139.0	COG0036@1|root,COG0036@2|Bacteria,2GJZ9@201174|Actinobacteria,22KMF@1653|Corynebacteriaceae	201174|Actinobacteria	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
k59_1398789_1	1219045.BV98_002690	9.65e-98	291.0	COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,2K2F6@204457|Sphingomonadales	204457|Sphingomonadales	L	COG2801 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve,rve_3
k59_453935_1	1120948.KB903218_gene2048	1.31e-09	57.8	COG1225@1|root,COG1225@2|Bacteria,2GKME@201174|Actinobacteria,4E2X5@85010|Pseudonocardiales	201174|Actinobacteria	O	PFAM AhpC TSA family	ahpE	GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0020012,GO:0030682,GO:0042221,GO:0043207,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0051920,GO:0052060,GO:0052173,GO:0052200,GO:0052376,GO:0052551,GO:0052564,GO:0052565,GO:0052572,GO:0055114,GO:0070887,GO:0075136,GO:0097237,GO:0098754,GO:0098869,GO:1990748	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	AhpC-TSA
k59_1233047_2	1459636.NTE_01419	6.04e-47	163.0	COG0016@1|root,arCOG00410@2157|Archaea,41S9U@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Phenylalanyl-tRNA synthetase alpha subunit	-	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2d
k59_175634_1	926569.ANT_07080	2.63e-49	168.0	COG0583@1|root,COG0583@2|Bacteria,2G77H@200795|Chloroflexi	200795|Chloroflexi	K	regulatory protein LysR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_64488_1	626887.J057_12666	4.83e-46	166.0	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,1RMSR@1236|Gammaproteobacteria,465J7@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	Belongs to the peptidase S41A family	ctpA	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
k59_1343115_1	74547.PMT_1262	1.69e-73	232.0	COG0524@1|root,COG0524@2|Bacteria,1G3P8@1117|Cyanobacteria,1MKS3@1212|Prochloraceae	1117|Cyanobacteria	G	Belongs to the carbohydrate kinase PfkB family	-	-	2.7.1.4	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	-	R00760,R00867,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
k59_1233050_1	518766.Rmar_1623	1.14e-92	278.0	COG3291@1|root,COG3291@2|Bacteria,4PMYH@976|Bacteroidetes	976|Bacteroidetes	S	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
k59_787419_1	794846.AJQU01000045_gene4360	1.33e-89	284.0	COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,2TQTQ@28211|Alphaproteobacteria,4B8GZ@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C
k59_1620874_1	1265503.KB905166_gene943	9.46e-29	114.0	COG1266@1|root,COG1266@2|Bacteria,1RJ14@1224|Proteobacteria,1SKGU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
k59_1343116_2	926569.ANT_00080	5.87e-31	115.0	COG1725@1|root,COG1725@2|Bacteria,2G7C5@200795|Chloroflexi	200795|Chloroflexi	K	PFAM regulatory protein GntR HTH	-	-	-	ko:K07979	-	-	-	-	ko00000,ko03000	-	-	-	GntR
k59_64490_1	1442599.JAAN01000043_gene480	1.62e-116	354.0	COG3661@1|root,COG3661@2|Bacteria,1MXKA@1224|Proteobacteria,1RP0V@1236|Gammaproteobacteria,1X5RV@135614|Xanthomonadales	135614|Xanthomonadales	G	Belongs to the glycosyl hydrolase 67 family	aguA	-	3.2.1.139	ko:K01235	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_hydro_67C,Glyco_hydro_67M,Glyco_hydro_67N
k59_175638_1	1121422.AUMW01000002_gene2198	1.42e-57	192.0	COG0332@1|root,COG0332@2|Bacteria,1TP0K@1239|Firmicutes,248V8@186801|Clostridia,260BR@186807|Peptococcaceae	186801|Clostridia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
k59_1454768_1	926562.Oweho_1541	8.39e-15	70.1	2A8XB@1|root,30Y0U@2|Bacteria,4NSDA@976|Bacteroidetes,1I4EZ@117743|Flavobacteriia	976|Bacteroidetes	S	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
k59_231548_1	85643.Tmz1t_0549	5.84e-60	204.0	COG4670@1|root,COG4670@2|Bacteria,1MUJW@1224|Proteobacteria,2VH8B@28216|Betaproteobacteria,2KVP5@206389|Rhodocyclales	206389|Rhodocyclales	I	CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons	-	-	2.8.3.1	ko:K01026	ko00620,ko00640,ko00643,ko01100,ko01120,map00620,map00640,map00643,map01100,map01120	-	R00928,R01449,R05508	RC00012,RC00014,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
k59_620300_1	379066.GAU_2684	8.75e-93	281.0	COG0583@1|root,COG0583@2|Bacteria,1ZUAH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_1676767_1	570952.ATVH01000013_gene2690	1.93e-91	281.0	COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,2TVFM@28211|Alphaproteobacteria,2JRI1@204441|Rhodospirillales	204441|Rhodospirillales	J	exonuclease of the beta-lactamase fold involved in RNA processing	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,RMMBL
k59_1398819_1	1379270.AUXF01000006_gene77	3.76e-59	204.0	COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,1ZSPW@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KT	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	SpoIIE
k59_231562_1	426355.Mrad2831_0174	8.64e-89	275.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,1JTYB@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	PFAM Aldehyde dehydrogenase	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_1398823_1	1499967.BAYZ01000102_gene3564	3.99e-48	170.0	COG4656@1|root,COG4656@2|Bacteria,2NNZN@2323|unclassified Bacteria	2|Bacteria	C	Part of a membrane complex involved in electron transport	rnfC	-	-	ko:K03615	-	-	-	-	ko00000	-	-	-	Complex1_51K,Fer4_10,Fer4_7,RnfC_N,SLBB
k59_1398823_2	870187.Thini_2682	8.28e-38	139.0	COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,1RMEU@1236|Gammaproteobacteria,45ZZZ@72273|Thiotrichales	1236|Gammaproteobacteria	C	Part of a membrane complex involved in electron transport	rnfD	-	-	ko:K03614	-	-	-	-	ko00000	-	-	-	NQR2_RnfD_RnfE
k59_1009875_1	448385.sce6555	7.93e-108	317.0	COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,42M2J@68525|delta/epsilon subdivisions,2WK9D@28221|Deltaproteobacteria,2YXAV@29|Myxococcales	28221|Deltaproteobacteria	C	Fumarate reductase, iron-sulfur protein	frdB	-	1.3.5.1,1.3.5.4	ko:K00240,ko:K00245	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00149,M00150,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2395	Fer2_3,Fer4_7,Fer4_8
k59_1121288_1	234267.Acid_3055	9.32e-45	170.0	COG0577@1|root,COG0577@2|Bacteria,3Y79Q@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_1567479_2	69014.TK1980	5.76e-39	141.0	COG0674@1|root,arCOG01608@2157|Archaea,2XTB0@28890|Euryarchaeota,242N1@183968|Thermococci	183968|Thermococci	C	3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity	vorA	-	1.2.7.7	ko:K00186	ko00280,ko01100,map00280,map01100	-	R07160,R08566,R08567	RC00004,RC02833,RC02856	br01601,ko00000,ko00001,ko01000	-	-	-	PFOR_II,POR_N
k59_121650_1	1385515.N791_04410	5.05e-05	45.4	COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,1RPTP@1236|Gammaproteobacteria,1X4MI@135614|Xanthomonadales	135614|Xanthomonadales	C	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppc	GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase
k59_1235052_1	1131814.JAFO01000001_gene2851	8.13e-54	179.0	COG0834@1|root,COG0834@2|Bacteria,1MV5D@1224|Proteobacteria,2TTXX@28211|Alphaproteobacteria,3F1W5@335928|Xanthobacteraceae	28211|Alphaproteobacteria	ET	Bacterial periplasmic substrate-binding proteins	gltI	-	-	ko:K02030,ko:K10001	ko02010,ko02020,map02010,map02020	M00230,M00236	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3,3.A.1.3.19,3.A.1.3.4	-	-	SBP_bac_3
k59_1011773_1	1500304.JQKY01000018_gene773	2.03e-26	107.0	COG2141@1|root,COG2141@2|Bacteria,1MUVN@1224|Proteobacteria,2TR26@28211|Alphaproteobacteria,4B70B@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_692623_1	485917.Phep_2766	1.48e-52	169.0	COG3832@1|root,COG3832@2|Bacteria,4NT4P@976|Bacteroidetes,1IZPU@117747|Sphingobacteriia	976|Bacteroidetes	S	PFAM Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
k59_1137559_1	1244869.H261_04917	1.84e-10	58.2	2C07J@1|root,32SWS@2|Bacteria,1N0NW@1224|Proteobacteria,2UCVR@28211|Alphaproteobacteria,2JTB5@204441|Rhodospirillales	204441|Rhodospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1137559_2	639283.Snov_2132	3.46e-64	203.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2TR61@28211|Alphaproteobacteria,3EYUN@335928|Xanthobacteraceae	28211|Alphaproteobacteria	E	ATPases associated with a variety of cellular activities	livF	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
k59_303097_1	1268072.PSAB_10930	5.32e-10	67.0	COG0744@1|root,COG0744@2|Bacteria,1TPM5@1239|Firmicutes,4H9SA@91061|Bacilli,26RUS@186822|Paenibacillaceae	91061|Bacilli	M	penicillin-binding protein	pbp1B	-	2.4.1.129	ko:K03693,ko:K12551	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
k59_747795_1	748247.AZKH_3382	4.98e-21	92.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2VK20@28216|Betaproteobacteria,2KZT3@206389|Rhodocyclales	206389|Rhodocyclales	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_358091_1	1123276.KB893253_gene3417	3.94e-19	82.4	COG3415@1|root,COG3415@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_28,HTH_32,HTH_33
k59_358091_2	1121377.KB906410_gene620	7.29e-63	196.0	COG3335@1|root,COG3335@2|Bacteria	2|Bacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_28,HTH_33
k59_1026846_1	189753.AXAS01000012_gene4337	2.25e-23	97.1	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
k59_358097_1	883080.HMPREF9697_02156	4.45e-76	234.0	COG0235@1|root,COG0235@2|Bacteria,1MWP9@1224|Proteobacteria,2TRMV@28211|Alphaproteobacteria,3JUHS@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Class II Aldolase and Adducin N-terminal domain	-	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
k59_857671_1	398525.KB900701_gene3352	3.09e-86	256.0	COG3260@1|root,COG3260@2|Bacteria,1QUBE@1224|Proteobacteria,2U279@28211|Alphaproteobacteria,3JTGI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	hycG	-	-	-	-	-	-	-	-	-	-	-	Oxidored_q6
k59_857671_2	1121861.KB899911_gene1297	1.65e-27	109.0	COG3261@1|root,COG3262@1|root,COG3261@2|Bacteria,COG3262@2|Bacteria,1QUBF@1224|Proteobacteria,2TRE0@28211|Alphaproteobacteria,2JR7I@204441|Rhodospirillales	204441|Rhodospirillales	C	Respiratory-chain NADH dehydrogenase, 49 Kd subunit	hyfG	-	-	-	-	-	-	-	-	-	-	-	Complex1_30kDa,Complex1_49kDa,NiFeSe_Hases
k59_1303909_1	1267535.KB906767_gene8	1.32e-12	70.9	COG0457@1|root,COG0457@2|Bacteria,3Y2M9@57723|Acidobacteria,2JMD8@204432|Acidobacteriia	204432|Acidobacteriia	S	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
k59_525376_2	1121936.AUHI01000004_gene1700	1.92e-13	65.9	COG3369@1|root,COG3369@2|Bacteria,1VFK3@1239|Firmicutes,4HNHY@91061|Bacilli	91061|Bacilli	S	SMART zinc finger CDGSH-type domain protein	-	-	-	-	-	-	-	-	-	-	-	-	zf-CDGSH
k59_803443_1	448385.sce2945	8.43e-48	164.0	COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,42N2N@68525|delta/epsilon subdivisions,2WK67@28221|Deltaproteobacteria,2Z25A@29|Myxococcales	28221|Deltaproteobacteria	U	probably responsible for the translocation of the substrate across the membrane	pstC	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	iAF987.Gmet_2702	BPD_transp_1
k59_135661_1	504472.Slin_6039	3.18e-30	123.0	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,4NDU8@976|Bacteroidetes,47M35@768503|Cytophagia	976|Bacteroidetes	P	PFAM TonB-dependent Receptor Plug	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
k59_1192622_1	589924.Ferp_2318	1.51e-85	271.0	COG1249@1|root,COG1902@1|root,arCOG00615@2157|Archaea,arCOG01068@2157|Archaea,2XT27@28890|Euryarchaeota,246QS@183980|Archaeoglobi	183980|Archaeoglobi	C	NADH oxidase	-	-	1.3.1.34	ko:K00219	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_FMN,Pyr_redox_2
k59_1249907_1	1411123.JQNH01000001_gene1879	1.87e-14	70.9	COG0727@1|root,COG0727@2|Bacteria,1N5PC@1224|Proteobacteria,2UFEE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
k59_1249907_2	438753.AZC_4176	2.24e-53	183.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TSB1@28211|Alphaproteobacteria,3EY38@335928|Xanthobacteraceae	28211|Alphaproteobacteria	EH	Thiamine pyrophosphate enzyme, central domain	MA20_00650	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_1137626_1	926569.ANT_20890	4.03e-61	208.0	COG0465@1|root,COG0465@2|Bacteria,2G5J3@200795|Chloroflexi	200795|Chloroflexi	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_525412_1	713587.THITH_06930	1.04e-59	207.0	COG0247@1|root,COG0277@1|root,COG1146@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,COG1146@2|Bacteria,1MU6Y@1224|Proteobacteria,1RM7Z@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	4Fe-4S ferredoxin	lldE	-	-	ko:K18930	-	-	-	-	ko00000	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_7,Fer4_8
k59_1470934_1	935845.JADQ01000007_gene1551	2.99e-65	207.0	COG0336@1|root,COG0336@2|Bacteria,1TPBV@1239|Firmicutes,4HBFV@91061|Bacilli,26RCU@186822|Paenibacillaceae	91061|Bacilli	J	Belongs to the RNA methyltransferase TrmD family	trmD	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
k59_692707_1	485913.Krac_9981	5.32e-59	201.0	COG1012@1|root,COG1012@2|Bacteria,2G83P@200795|Chloroflexi	200795|Chloroflexi	C	belongs to the aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
k59_1359497_3	234267.Acid_7247	0.000673	43.1	COG1595@1|root,COG1595@2|Bacteria,3Y815@57723|Acidobacteria	57723|Acidobacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_970765_1	1041159.AZUW01000005_gene5455	1.92e-37	138.0	COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,2TVQR@28211|Alphaproteobacteria,4B71Y@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	esterase of the alpha-beta hydrolase superfamily	rssA	GO:0003674,GO:0003824,GO:0016787	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
k59_525431_1	1123288.SOV_1c11490	4.94e-17	81.3	COG1488@1|root,COG1488@2|Bacteria,1TPDW@1239|Firmicutes,4H2WK@909932|Negativicutes	909932|Negativicutes	H	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	-	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	QRPTase_C,QRPTase_N
k59_303194_1	518766.Rmar_1750	5.11e-14	75.5	COG1629@1|root,COG4774@1|root,COG1629@2|Bacteria,COG4774@2|Bacteria,4P230@976|Bacteroidetes	2|Bacteria	P	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	CarbopepD_reg_2,CarboxypepD_reg,Plug,STN,TonB_dep_Rec
k59_916037_1	391937.NA2_04611	9.57e-40	137.0	COG0346@1|root,COG0346@2|Bacteria,1RIN8@1224|Proteobacteria,2U9WM@28211|Alphaproteobacteria,43K76@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	bleomycin resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
k59_692740_1	420324.KI912044_gene3926	6.29e-116	337.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,1JW30@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	transposase IS116 IS110 IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1304007_1	1453501.JELR01000001_gene3168	1.47e-31	127.0	COG2304@1|root,COG2304@2|Bacteria,1MW8K@1224|Proteobacteria,1RNU3@1236|Gammaproteobacteria,46676@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	protein containing a von Willebrand factor type A (vWA) domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VIT,VWA_3
k59_471040_1	1280706.AUJE01000031_gene430	4.36e-45	165.0	COG0557@1|root,COG0557@2|Bacteria,1TQ1G@1239|Firmicutes,4H23F@909932|Negativicutes	909932|Negativicutes	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
k59_303219_1	1033743.CAES01000032_gene973	3.75e-40	151.0	COG0587@1|root,COG0587@2|Bacteria,1TPYG@1239|Firmicutes,4H9T3@91061|Bacilli,26QTS@186822|Paenibacillaceae	91061|Bacilli	L	DNA polymerase	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_1747785_1	285535.JOEY01000008_gene8800	4.22e-18	81.3	COG0346@1|root,COG0346@2|Bacteria,2I94W@201174|Actinobacteria	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
k59_1304023_1	880072.Desac_0158	9.34e-85	257.0	COG1215@1|root,COG1215@2|Bacteria,1QU2F@1224|Proteobacteria,42P7H@68525|delta/epsilon subdivisions,2WKJA@28221|Deltaproteobacteria,2MQD3@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,GtrA
k59_1137710_1	1502851.FG93_06077	7.13e-42	148.0	COG0760@1|root,COG0760@2|Bacteria,1R4ZR@1224|Proteobacteria,2U874@28211|Alphaproteobacteria,3JRK1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	PPIC-type PPIASE domain	-	-	5.2.1.8	ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_2
k59_857772_1	266117.Rxyl_0428	1.45e-17	78.2	COG5588@1|root,COG5588@2|Bacteria,2HIPH@201174|Actinobacteria,4CTK9@84995|Rubrobacteria	84995|Rubrobacteria	S	Protein of unknown function (DUF1326)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1326
k59_857772_2	1458357.BG58_18260	7.3e-27	108.0	COG0477@1|root,COG2814@2|Bacteria,1R2KY@1224|Proteobacteria,2VI3X@28216|Betaproteobacteria,1K55G@119060|Burkholderiaceae	28216|Betaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1026943_1	1528106.JRJE01000009_gene1750	4.15e-71	223.0	COG1262@1|root,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria,2U2VJ@28211|Alphaproteobacteria,2JS16@204441|Rhodospirillales	204441|Rhodospirillales	T	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,Peptidase_C14
k59_1414841_1	338969.Rfer_2478	2.13e-09	63.9	COG0028@1|root,COG0028@2|Bacteria,1MXDW@1224|Proteobacteria,2VI39@28216|Betaproteobacteria	28216|Betaproteobacteria	EH	Belongs to the TPP enzyme family	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_1137718_1	926569.ANT_00520	1.46e-31	117.0	COG3063@1|root,COG3063@2|Bacteria,2G79Z@200795|Chloroflexi	200795|Chloroflexi	NU	Type IV pilus biogenesis stability protein PilW	-	-	-	-	-	-	-	-	-	-	-	-	zf-B_box
k59_1137718_2	926569.ANT_00510	1.18e-57	188.0	COG0061@1|root,COG0061@2|Bacteria,2G6NK@200795|Chloroflexi	200795|Chloroflexi	F	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
k59_247112_2	696281.Desru_3258	5.56e-45	152.0	COG0431@1|root,COG0431@2|Bacteria,1V41C@1239|Firmicutes,25BUB@186801|Clostridia,2674C@186807|Peptococcaceae	186801|Clostridia	S	PFAM NADPH-dependent FMN reductase	-	-	-	ko:K19784	-	-	-	-	ko00000	-	-	-	FMN_red
k59_525497_1	926569.ANT_13980	1.74e-88	267.0	COG1192@1|root,COG1192@2|Bacteria,2G62U@200795|Chloroflexi	200795|Chloroflexi	D	PFAM Cobyrinic acid a,c-diamide synthase	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
k59_803575_1	926569.ANT_00880	1.19e-46	168.0	COG0488@1|root,COG0488@2|Bacteria,2G5VD@200795|Chloroflexi	200795|Chloroflexi	S	PFAM ABC transporter related	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
k59_1526065_1	266117.Rxyl_3051	2.69e-56	189.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5,DDE_Tnp_1
k59_692793_1	338966.Ppro_2168	7.59e-74	234.0	COG3919@1|root,COG3919@2|Bacteria,1N13P@1224|Proteobacteria,42WGT@68525|delta/epsilon subdivisions,2WRKR@28221|Deltaproteobacteria,43VRY@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_3
k59_358207_1	930169.B5T_04307	5.38e-20	87.8	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,1RVGG@1236|Gammaproteobacteria,1XIDT@135619|Oceanospirillales	135619|Oceanospirillales	G	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_1693600_1	1396141.BATP01000028_gene2285	6.65e-31	126.0	COG4412@1|root,COG5306@1|root,COG4412@2|Bacteria,COG5306@2|Bacteria	2|Bacteria	S	peptidase activity, acting on L-amino acid peptides	-	-	-	ko:K07004,ko:K09955,ko:K12287	-	-	-	-	ko00000,ko02044	-	-	-	Big_4,F5_F8_type_C,Laminin_G_3
k59_358218_1	1380391.JIAS01000013_gene3730	1.58e-95	303.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,2TR3C@28211|Alphaproteobacteria,2JP8K@204441|Rhodospirillales	204441|Rhodospirillales	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_1304061_1	485913.Krac_3678	6.07e-54	172.0	COG1720@1|root,COG1720@2|Bacteria,2G799@200795|Chloroflexi	200795|Chloroflexi	S	Uncharacterised protein family UPF0066	-	-	-	-	-	-	-	-	-	-	-	-	UPF0066
k59_1304061_2	1415780.JPOG01000001_gene1457	6.19e-28	108.0	COG2267@1|root,COG2267@2|Bacteria,1MUG8@1224|Proteobacteria,1RMFE@1236|Gammaproteobacteria,1X43J@135614|Xanthomonadales	135614|Xanthomonadales	I	Alpha beta hydrolase	cpo	-	1.11.1.10	ko:K00433	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_1
k59_471108_2	1313172.YM304_32130	9.59e-68	221.0	COG1236@1|root,COG1236@2|Bacteria,2HEXB@201174|Actinobacteria	201174|Actinobacteria	J	Beta-lactamase	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_2,RMMBL
k59_859326_1	326427.Cagg_3786	1.38e-06	55.5	COG0628@1|root,COG0628@2|Bacteria,2G6TV@200795|Chloroflexi,3751W@32061|Chloroflexia	32061|Chloroflexia	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
k59_1472613_2	717605.Theco_0419	1.42e-58	192.0	COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,4HBB9@91061|Bacilli,26Q9W@186822|Paenibacillaceae	91061|Bacilli	EP	ABC transporter permease	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
k59_917920_1	861299.J421_1976	2.85e-43	160.0	COG0008@1|root,COG0008@2|Bacteria,1ZTAC@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	tRNA synthetases class I (E and Q), anti-codon binding domain	glnS	-	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
k59_1361168_1	927677.ALVU02000002_gene292	1.79e-120	353.0	COG3039@1|root,COG3039@2|Bacteria,1G1EK@1117|Cyanobacteria	1117|Cyanobacteria	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_3
k59_527075_1	1247963.JPHU01000014_gene1003	9.99e-09	53.5	2DNW5@1|root,32ZGI@2|Bacteria,1MZA8@1224|Proteobacteria,2UD5I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	COG3668 Plasmid stabilization system protein	-	-	-	-	-	-	-	-	-	-	-	-	Rho_N
k59_1583387_1	215803.DB30_2329	2.28e-11	70.5	COG0577@1|root,COG4591@1|root,COG0577@2|Bacteria,COG4591@2|Bacteria,1NR2V@1224|Proteobacteria,42YIK@68525|delta/epsilon subdivisions,2WUNG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	MV	MacB-like periplasmic core domain	lolE-2	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_581850_1	1123368.AUIS01000024_gene950	6.6e-78	243.0	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,1SYDD@1236|Gammaproteobacteria,2NCJF@225057|Acidithiobacillales	225057|Acidithiobacillales	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
k59_415874_1	1459636.NTE_02192	1.12e-47	166.0	COG1249@1|root,arCOG01068@2157|Archaea	2157|Archaea	C	COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes	lpdA2	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_472871_1	864051.BurJ1DRAFT_2687	2.66e-94	290.0	COG2391@1|root,COG2391@2|Bacteria,1RIWE@1224|Proteobacteria,2VWMP@28216|Betaproteobacteria,1KNZM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Sulphur transport	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
k59_472877_1	179408.Osc7112_4309	2.21e-26	110.0	COG0451@1|root,COG0451@2|Bacteria,1G559@1117|Cyanobacteria	1117|Cyanobacteria	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
k59_749437_2	1123229.AUBC01000010_gene3417	1.31e-20	90.9	COG1003@1|root,COG1003@2|Bacteria,1MUDP@1224|Proteobacteria,2TSFF@28211|Alphaproteobacteria,3JUAJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvP	-	1.4.4.2	ko:K00281,ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5,GDC-P
k59_359817_1	1331060.RLDS_17835	5.5e-22	99.0	COG4372@1|root,COG4372@2|Bacteria,1MUCX@1224|Proteobacteria,2TR59@28211|Alphaproteobacteria,2KEBT@204457|Sphingomonadales	204457|Sphingomonadales	L	zinc-finger binding domain of transposase IS66	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
k59_472880_1	56110.Oscil6304_3431	1.36e-34	142.0	COG0305@1|root,COG1372@1|root,COG0305@2|Bacteria,COG1372@2|Bacteria,1G0R8@1117|Cyanobacteria,1H75W@1150|Oscillatoriales	1117|Cyanobacteria	L	Participates in initiation and elongation during chromosome replication	dnaB	GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0032392,GO:0032508,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C,Intein_splicing,LAGLIDADG_3
k59_1695274_1	340177.Cag_0064	4.12e-16	80.9	COG0356@1|root,COG0356@2|Bacteria,1FEM0@1090|Chlorobi	1090|Chlorobi	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
k59_1041698_2	749222.Nitsa_0867	3.78e-37	140.0	COG0474@1|root,COG0475@1|root,COG0474@2|Bacteria,COG0475@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2YNQF@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	P	COG0474 Cation transport ATPase	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3,Na_H_Exchanger
k59_985389_2	457415.HMPREF1006_00689	5.44e-24	103.0	COG1804@1|root,COG1804@2|Bacteria,3T9W8@508458|Synergistetes	508458|Synergistetes	C	PFAM L-carnitine dehydratase bile acid-inducible protein F	-	-	2.8.3.16,2.8.3.19	ko:K07749,ko:K18702	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
k59_648262_1	1122929.KB908215_gene1204	3.14e-31	117.0	COG3749@1|root,COG3749@2|Bacteria,1RJR9@1224|Proteobacteria,2UAVF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Bacterial protein of unknown function (DUF934)	-	-	-	-	-	-	-	-	-	-	-	-	DUF934
k59_648262_2	1282876.BAOK01000001_gene3373	9.35e-05	44.3	COG0260@1|root,COG0260@2|Bacteria,1MUIN@1224|Proteobacteria,2TSI6@28211|Alphaproteobacteria,4BPDP@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the peptidase M17 family	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17
k59_761037_1	313606.M23134_01148	6.21e-35	130.0	2F4SK@1|root,33XF9@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_706905_1	443254.Marpi_1454	7.33e-07	57.0	COG0612@1|root,COG0612@2|Bacteria,2GCT0@200918|Thermotogae	200918|Thermotogae	S	Peptidase, M16	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_1205915_1	244582.JQAK01000001_gene2027	1.12e-29	116.0	COG1040@1|root,COG1040@2|Bacteria,1RHAV@1224|Proteobacteria,2TV7G@28211|Alphaproteobacteria,47FBZ@766|Rickettsiales	766|Rickettsiales	S	Phosphoribosyl transferase domain	comF	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
k59_371972_1	1038859.AXAU01000003_gene6192	1.64e-40	153.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2TRWM@28211|Alphaproteobacteria,3JVS5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1205918_1	234267.Acid_0438	2.81e-14	75.5	COG0664@1|root,COG4191@1|root,COG0664@2|Bacteria,COG4191@2|Bacteria,3Y99Q@57723|Acidobacteria	57723|Acidobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
k59_1205918_2	755732.Fluta_2077	1.09e-29	110.0	COG2166@1|root,COG2166@2|Bacteria,4NM9N@976|Bacteroidetes,1I187@117743|Flavobacteriia,2PAUU@246874|Cryomorphaceae	976|Bacteroidetes	S	SufE protein probably involved in Fe-S center assembly	sufE	-	-	ko:K02426	-	-	-	-	ko00000	-	-	-	SufE
k59_648275_1	1274524.BSONL12_19454	0.000552	44.3	COG0706@1|root,COG0706@2|Bacteria,1TQ0J@1239|Firmicutes,4HB3J@91061|Bacilli,1ZBYD@1386|Bacillus	91061|Bacilli	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins	yidC	GO:0005575,GO:0008150,GO:0009653,GO:0009987,GO:0016020,GO:0030154,GO:0030435,GO:0032502,GO:0043934,GO:0048646,GO:0048856,GO:0048869	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP
k59_648275_2	744872.Spica_2098	1.09e-08	59.7	COG0486@1|root,COG0486@2|Bacteria,2J5GU@203691|Spirochaetes	203691|Spirochaetes	J	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	-	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
k59_871859_1	485913.Krac_9327	4.93e-34	132.0	COG3547@1|root,COG3547@2|Bacteria	2|Bacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_593936_1	1380394.JADL01000002_gene1647	1.71e-50	177.0	COG5002@1|root,COG5002@2|Bacteria,1QU7C@1224|Proteobacteria,2TWBW@28211|Alphaproteobacteria,2JPN9@204441|Rhodospirillales	204441|Rhodospirillales	T	Stimulus-sensing domain	chvG	-	2.7.13.3	ko:K14980	ko02020,map02020	M00520	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,Sensor_TM1,Stimulus_sens_1
k59_1318902_1	1313304.CALK_1612	5.18e-36	139.0	COG2385@1|root,COG2385@2|Bacteria	2|Bacteria	D	sporulation resulting in formation of a cellular spore	-	-	-	ko:K06381	-	-	-	-	ko00000	-	-	-	SpoIID,TPR_16,TPR_8
k59_1708326_1	1191523.MROS_2662	2.51e-42	149.0	COG0167@1|root,COG0167@2|Bacteria	2|Bacteria	F	dihydroorotate dehydrogenase activity	-	-	1.3.98.1	ko:K00226	ko00240,ko01100,map00240,map01100	M00051	R01867	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
k59_1760341_1	246196.MSMEI_2200	7.79e-43	150.0	COG2141@1|root,COG2141@2|Bacteria,2GNE9@201174|Actinobacteria,232XS@1762|Mycobacteriaceae	201174|Actinobacteria	C	F420-dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_1760341_2	2903.EOD11927	2.54e-10	60.1	KOG1681@1|root,KOG1681@2759|Eukaryota	2759|Eukaryota	S	delta3,5-delta2,4-dienoyl-CoA isomerase activity	-	-	4.1.3.4	ko:K01640	ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146	M00036,M00088	R01360,R08090	RC00502,RC00503,RC01118,RC01946	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1,HMGL-like
k59_761066_1	1120983.KB894571_gene2480	4.17e-42	151.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,2TSR0@28211|Alphaproteobacteria,1JPCC@119043|Rhodobiaceae	28211|Alphaproteobacteria	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
k59_761066_2	36809.MAB_4797	2.36e-39	139.0	COG2141@1|root,COG2141@2|Bacteria,2GJ6T@201174|Actinobacteria,234RA@1762|Mycobacteriaceae	201174|Actinobacteria	C	F420-dependent oxidoreductase, Rv1855c family	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_1484873_1	237368.SCABRO_03849	4.02e-74	235.0	COG0767@1|root,COG0767@2|Bacteria,2IX01@203682|Planctomycetes	203682|Planctomycetes	Q	Belongs to the MlaE permease family	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
k59_816844_1	84531.JMTZ01000032_gene310	7.95e-48	166.0	COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,1RPJE@1236|Gammaproteobacteria,1X2Y5@135614|Xanthomonadales	135614|Xanthomonadales	LU	DNA processing protein DprA	smf	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
k59_94045_2	1121875.KB907549_gene1768	4.64e-08	62.0	COG0642@1|root,COG2199@1|root,COG3292@1|root,COG2205@2|Bacteria,COG3292@2|Bacteria,COG3706@2|Bacteria,4NG28@976|Bacteroidetes,1I1IG@117743|Flavobacteriia	976|Bacteroidetes	KT	regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Reg_prop,Y_Y_Y
k59_427609_1	1122164.JHWF01000025_gene68	2.24e-23	102.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,1JCH1@118969|Legionellales	118969|Legionellales	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	yfcX	-	1.1.1.35,4.2.1.17,5.1.2.3	ko:K01782	ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
k59_538914_1	926569.ANT_20590	1.67e-25	102.0	COG4260@1|root,COG4260@2|Bacteria,2G6J2@200795|Chloroflexi	200795|Chloroflexi	S	SPFH domain-Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7_1,HTH_17,zinc_ribbon_2
k59_538914_2	926569.ANT_14480	2.29e-42	146.0	COG1975@1|root,COG1975@2|Bacteria,2G6H0@200795|Chloroflexi	200795|Chloroflexi	O	XdhC Rossmann domain	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
k59_94052_1	1304284.L21TH_0983	5.25e-67	219.0	COG0541@1|root,COG0541@2|Bacteria,1TP06@1239|Firmicutes,248EU@186801|Clostridia,36E8W@31979|Clostridiaceae	186801|Clostridia	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
k59_1595938_1	91464.S7335_4328	7.52e-77	240.0	COG0444@1|root,COG0444@2|Bacteria	2|Bacteria	P	Belongs to the ABC transporter superfamily	oppD	-	-	ko:K02031,ko:K02032,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
k59_1095450_1	324602.Caur_0718	5.24e-13	68.9	COG1476@1|root,COG3903@1|root,COG1476@2|Bacteria,COG3903@2|Bacteria,2G64X@200795|Chloroflexi,376A5@32061|Chloroflexia	32061|Chloroflexia	K	PFAM helix-turn-helix domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31,NB-ARC,TPR_12
k59_1095450_2	926569.ANT_29500	1.56e-33	122.0	COG1595@1|root,COG1595@2|Bacteria,2G6MG@200795|Chloroflexi	200795|Chloroflexi	K	sigma-70 region 2 domain protein	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_1428446_2	1380387.JADM01000002_gene2243	2.24e-40	143.0	COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,1RP6Z@1236|Gammaproteobacteria,1XIRB@135619|Oceanospirillales	135619|Oceanospirillales	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
k59_485522_2	1123024.AUII01000013_gene419	2.88e-30	117.0	COG0609@1|root,COG0609@2|Bacteria,2GK8Z@201174|Actinobacteria,4E0ZT@85010|Pseudonocardiales	201174|Actinobacteria	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
k59_1648967_1	743718.Isova_2270	1.67e-08	60.8	COG0747@1|root,COG0747@2|Bacteria,2GJ4B@201174|Actinobacteria,4F4T6@85017|Promicromonosporaceae	201174|Actinobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	appA	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_1205973_1	379066.GAU_0239	2.33e-43	157.0	2E0UX@1|root,32WC9@2|Bacteria,1ZUE1@142182|Gemmatimonadetes	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
k59_1538905_1	518766.Rmar_1596	8.59e-66	213.0	COG0010@1|root,COG0010@2|Bacteria,4NEFA@976|Bacteroidetes	976|Bacteroidetes	E	Belongs to the arginase family	hutG	-	3.5.3.7,3.5.3.8	ko:K01479,ko:K12255	ko00330,ko00340,ko01100,map00330,map00340,map01100	M00045	R01990,R02285	RC00024,RC00221,RC00329,RC00681	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
k59_1708366_2	402777.KB235903_gene2239	6.92e-18	79.3	COG0521@1|root,COG0521@2|Bacteria,1G514@1117|Cyanobacteria,1HB1C@1150|Oscillatoriales	1117|Cyanobacteria	H	May be involved in the biosynthesis of molybdopterin	moaB	-	2.7.7.75	ko:K03638,ko:K03831	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09726	RC00002	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth
k59_1538909_1	688245.CtCNB1_2656	7.8e-54	191.0	COG0503@1|root,COG0827@1|root,COG3087@1|root,COG0503@2|Bacteria,COG0827@2|Bacteria,COG3087@2|Bacteria,1QZ6D@1224|Proteobacteria,2WI2K@28216|Betaproteobacteria,4AK49@80864|Comamonadaceae	28216|Betaproteobacteria	DFL	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_538938_1	1396858.Q666_08825	3.48e-57	189.0	COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,1RMTM@1236|Gammaproteobacteria,4659J@72275|Alteromonadaceae	1236|Gammaproteobacteria	F	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
k59_931046_1	1042326.AZNV01000022_gene969	8.61e-09	59.7	COG0834@1|root,COG0834@2|Bacteria,1NN6F@1224|Proteobacteria,2TSA4@28211|Alphaproteobacteria,4BCS9@82115|Rhizobiaceae	28211|Alphaproteobacteria	ET	Ligand-gated ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2,Lig_chan,SBP_bac_3
k59_871927_1	1217720.ALOX01000071_gene636	8.91e-46	157.0	COG0388@1|root,COG0388@2|Bacteria,1MXG5@1224|Proteobacteria,2TVCS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	3.5.1.77	ko:K01459	-	-	-	-	ko00000,ko01000	-	-	-	CN_hydrolase
k59_871927_2	861208.AGROH133_15093	2.67e-25	103.0	COG0604@1|root,COG0604@2|Bacteria,1MXRX@1224|Proteobacteria,2TRSQ@28211|Alphaproteobacteria,4BDF6@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	Zinc-binding dehydrogenase	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_203986_2	1158607.UAU_03948	1.23e-18	81.3	COG1694@1|root,COG1694@2|Bacteria,1U0SS@1239|Firmicutes,4IA8E@91061|Bacilli,4B588@81852|Enterococcaceae	91061|Bacilli	S	Mazg nucleotide pyrophosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_985489_1	1379270.AUXF01000004_gene3047	3.46e-71	241.0	COG0085@1|root,COG0085@2|Bacteria,1ZSQH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_1041812_1	926550.CLDAP_21640	1.26e-24	100.0	COG4770@1|root,COG4770@2|Bacteria	2|Bacteria	I	CoA carboxylase activity	pccA	-	6.4.1.3	ko:K01965,ko:K02160	ko00061,ko00280,ko00620,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00373,M00376,M00741	R00742,R01859	RC00040,RC00097,RC00367,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
k59_1318980_1	671143.DAMO_0444	1.38e-123	359.0	COG0330@1|root,COG0330@2|Bacteria,2NNUC@2323|unclassified Bacteria	2|Bacteria	O	prohibitin homologues	hflC	-	-	-	-	-	-	-	-	-	-	-	Band_7
k59_1264136_1	492774.JQMB01000002_gene1279	7.95e-28	109.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria,4BAUR@82115|Rhizobiaceae	28211|Alphaproteobacteria	I	Belongs to the thiolase family	atoB	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_1264136_2	522306.CAP2UW1_4329	2.1e-53	175.0	COG3917@1|root,COG3917@2|Bacteria,1RDNQ@1224|Proteobacteria,2VQJ1@28216|Betaproteobacteria,1KQTA@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	Q	DSBA-like thioredoxin domain	-	-	5.99.1.4	ko:K14584	ko00626,ko01100,ko01120,ko01220,map00626,map01100,map01120,map01220	M00534	R05137	RC03084	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	DSBA
k59_1041820_1	1379270.AUXF01000001_gene2301	5.56e-32	128.0	COG0457@1|root,COG4783@1|root,COG0457@2|Bacteria,COG4783@2|Bacteria,1ZUF5@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_763128_1	448385.sce6753	1.18e-63	212.0	COG3867@1|root,COG3867@2|Bacteria,1R33X@1224|Proteobacteria	1224|Proteobacteria	G	Arabinogalactan endo-beta-1,4-galactanase	-	-	3.2.1.89	ko:K01224	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_hydro_53
k59_933298_1	318161.Sden_3184	3.02e-15	80.1	COG2303@1|root,COG2303@2|Bacteria,1P9UF@1224|Proteobacteria,1RPS8@1236|Gammaproteobacteria,2Q9U3@267890|Shewanellaceae	1236|Gammaproteobacteria	E	PFAM glucose-methanol-choline oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
k59_763137_1	414684.RC1_2957	6.96e-54	179.0	COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,2TRUF@28211|Alphaproteobacteria,2JQTD@204441|Rhodospirillales	204441|Rhodospirillales	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA,HrcA_DNA-bdg
k59_596174_1	861299.J421_2868	8.19e-48	172.0	COG2366@1|root,COG2366@2|Bacteria,1ZT5C@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
k59_1540877_1	1191523.MROS_1373	9.38e-12	63.9	COG0436@1|root,COG0436@2|Bacteria	2|Bacteria	E	Aminotransferase	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_1540877_2	926554.KI912641_gene893	1.43e-45	165.0	COG1866@1|root,COG1866@2|Bacteria,1WIQ3@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA	pckA	GO:0003674,GO:0003824,GO:0004611,GO:0004612,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016829,GO:0016830,GO:0016831,GO:0019318,GO:0019319,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0071704,GO:1901576	4.1.1.49	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00170	R00341	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_ATP
k59_1043902_1	1121396.KB893104_gene1786	5.38e-27	108.0	COG3208@1|root,COG3208@2|Bacteria,1RGYT@1224|Proteobacteria,42X72@68525|delta/epsilon subdivisions,2WV7J@28221|Deltaproteobacteria,2MP6M@213118|Desulfobacterales	28221|Deltaproteobacteria	Q	Thioesterase domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioesterase
k59_540947_1	491205.JARQ01000006_gene2890	5.76e-42	144.0	COG4430@1|root,COG4430@2|Bacteria,4NN4Z@976|Bacteroidetes,1I213@117743|Flavobacteriia,3ZR05@59732|Chryseobacterium	976|Bacteroidetes	S	Bacteriocin-protection protein	-	-	-	-	-	-	-	-	-	-	-	-	OmdA
k59_1208066_1	640512.BC1003_2437	1.74e-42	151.0	COG0583@1|root,COG0583@2|Bacteria,1N8HZ@1224|Proteobacteria,2VJGT@28216|Betaproteobacteria,1JZQT@119060|Burkholderiaceae	28216|Betaproteobacteria	K	transcriptional Regulator, LysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_429728_2	999423.HMPREF9161_00781	9.59e-14	70.9	COG0030@1|root,COG0030@2|Bacteria,1TP9W@1239|Firmicutes,4H210@909932|Negativicutes	909932|Negativicutes	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
k59_1710473_1	1127673.GLIP_0674	5.34e-34	132.0	COG2148@1|root,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,1RMMN@1236|Gammaproteobacteria,464MI@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	COG2148 Sugar transferases involved in lipopolysaccharide synthesis	lthA	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
k59_1208074_1	1128421.JAGA01000003_gene3053	6.31e-23	100.0	COG0642@1|root,COG5002@1|root,COG2205@2|Bacteria,COG5002@2|Bacteria,2NPIU@2323|unclassified Bacteria	2|Bacteria	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_8,Response_reg,dCache_1
k59_487530_1	1411123.JQNH01000001_gene2693	4.33e-80	245.0	COG1540@1|root,COG1540@2|Bacteria,1MUYV@1224|Proteobacteria,2TQUC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Belongs to the UPF0271 (lamB) family	ybgL	-	-	ko:K07160	-	-	-	-	ko00000	-	-	-	LamB_YcsF
k59_429744_1	237368.SCABRO_00954	4.16e-66	217.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_4
k59_1651108_1	6412.HelroP99817	9.51e-80	247.0	COG1028@1|root,KOG0725@2759|Eukaryota,38BUC@33154|Opisthokonta,3BC34@33208|Metazoa,3D09G@33213|Bilateria	33208|Metazoa	Q	Oxidoreductase activity. It is involved in the biological process described with metabolic process	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
k59_1430713_1	351607.Acel_0906	3.2e-11	68.9	COG0683@1|root,COG0683@2|Bacteria,2HTRQ@201174|Actinobacteria,4ETY3@85013|Frankiales	201174|Actinobacteria	E	Periplasmic binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
k59_1430713_2	93220.LV28_24445	5.13e-60	191.0	COG0778@1|root,COG0778@2|Bacteria,1PG8V@1224|Proteobacteria,2VKIZ@28216|Betaproteobacteria,1K24T@119060|Burkholderiaceae	28216|Betaproteobacteria	C	nitroreductase	nfnB	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
k59_206032_1	6412.HelroP185412	2.2e-14	77.4	COG0436@1|root,KOG0258@2759|Eukaryota,38H3G@33154|Opisthokonta,3B98X@33208|Metazoa,3CTZ7@33213|Bilateria	33208|Metazoa	E	alanine-oxo-acid transaminase activity	GPT2	GO:0003674,GO:0003824,GO:0004021,GO:0005488,GO:0005575,GO:0005576,GO:0005615,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006082,GO:0006103,GO:0006520,GO:0006522,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009078,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019752,GO:0019842,GO:0030170,GO:0031974,GO:0036094,GO:0042851,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044421,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0047635,GO:0048037,GO:0050662,GO:0051186,GO:0070013,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.6.1.2	ko:K00814	ko00220,ko00250,ko00710,ko01100,ko01120,ko01200,ko01210,ko01230,map00220,map00250,map00710,map01100,map01120,map01200,map01210,map01230	M00171	R00258	RC00006,RC00008	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_1487169_2	1347392.CCEZ01000043_gene251	5.12e-28	116.0	COG0013@1|root,COG0013@2|Bacteria,1TPK6@1239|Firmicutes,248M3@186801|Clostridia,36E03@31979|Clostridiaceae	186801|Clostridia	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
k59_1710528_1	1333998.M2A_0448	2.24e-20	88.2	COG2928@1|root,COG2928@2|Bacteria,1MWT5@1224|Proteobacteria,2TZPK@28211|Alphaproteobacteria,4BQ42@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF502)	MA20_12960	-	-	-	-	-	-	-	-	-	-	-	DUF502
k59_1710528_2	1230476.C207_01555	8.36e-48	167.0	COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,2TQPM@28211|Alphaproteobacteria,3JU26@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
k59_541017_1	862515.HMPREF0658_0423	1.68e-20	95.1	COG2509@1|root,COG2509@2|Bacteria,4NEUQ@976|Bacteroidetes,2FM1G@200643|Bacteroidia	976|Bacteroidetes	S	Psort location Cytoplasmic, score	-	-	-	ko:K07137	-	-	-	-	ko00000	-	-	-	FAD_binding_2,FAD_binding_3,GIDA,HI0933_like,Pyr_redox_2
k59_1710532_1	278963.ATWD01000001_gene3574	1.27e-96	290.0	COG1023@1|root,COG1023@2|Bacteria,3Y2ZP@57723|Acidobacteria,2JHSA@204432|Acidobacteriia	204432|Acidobacteriia	G	6-phosphogluconate dehydrogenase (Decarboxylating)	-	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
k59_96416_1	671143.DAMO_2214	1.24e-94	305.0	COG4581@1|root,COG4581@2|Bacteria,2NPG6@2323|unclassified Bacteria	2|Bacteria	L	helicase superfamily c-terminal domain	helY	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0030312,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360,GO:1901361,GO:1901575	-	ko:K03727	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,DSHCT,Helicase_C,rRNA_proc-arch
k59_725130_1	1346791.M529_19270	4.14e-78	236.0	COG3335@1|root,COG3335@2|Bacteria,1P76X@1224|Proteobacteria,2U16U@28211|Alphaproteobacteria,2K5DS@204457|Sphingomonadales	204457|Sphingomonadales	L	Transposase or inactivated derivative	-	-	-	ko:K07494	-	-	-	-	ko00000	-	-	-	DDE_3
k59_280249_1	47839.CCAU010000011_gene5371	1.72e-07	56.2	COG1309@1|root,COG1309@2|Bacteria,2IF5X@201174|Actinobacteria,237M4@1762|Mycobacteriaceae	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_1003031_1	1408418.JNJH01000012_gene3556	0.000298	42.7	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQPG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains	-	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1003031_2	1267535.KB906767_gene3338	3.6e-48	167.0	COG1446@1|root,COG1446@2|Bacteria,3Y2Y8@57723|Acidobacteria,2JIW3@204432|Acidobacteriia	204432|Acidobacteriia	E	Asparaginase	-	-	3.5.1.26	ko:K01444	ko00511,ko04142,map00511,map04142	-	-	-	ko00000,ko00001,ko01000	-	-	-	Asparaginase_2
k59_1169757_1	331869.BAL199_24474	3.44e-28	112.0	COG0683@1|root,COG0683@2|Bacteria,1MWQB@1224|Proteobacteria,2U0KM@28211|Alphaproteobacteria,4BSBD@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_1169757_2	1207063.P24_16370	8.34e-48	160.0	COG0411@1|root,COG0411@2|Bacteria,1MVAU@1224|Proteobacteria,2TVRN@28211|Alphaproteobacteria,2JVDX@204441|Rhodospirillales	204441|Rhodospirillales	E	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,BCA_ABC_TP_C
k59_2382_1	941449.dsx2_3242	6.12e-29	119.0	COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WJCX@28221|Deltaproteobacteria,2MH92@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,CHASE,DUF3365,GAF_2,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg
k59_391486_1	411464.DESPIG_01696	1.15e-33	132.0	COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,42MZJ@68525|delta/epsilon subdivisions,2WJK1@28221|Deltaproteobacteria,2M804@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
k59_669490_1	1380394.JADL01000005_gene5358	4.95e-106	326.0	COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,2TQZV@28211|Alphaproteobacteria,2JPPI@204441|Rhodospirillales	204441|Rhodospirillales	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parE	-	-	ko:K02622	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_725142_1	926569.ANT_02230	2.63e-62	203.0	COG0618@1|root,COG0618@2|Bacteria,2G6RF@200795|Chloroflexi	200795|Chloroflexi	S	PFAM phosphoesterase, RecJ domain protein	-	-	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
k59_669498_1	344747.PM8797T_18876	1.67e-55	189.0	COG3119@1|root,COG3119@2|Bacteria,2J2DZ@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A	-	-	3.1.6.8	ko:K01134	ko00600,ko04142,map00600,map04142	-	R04856	RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase,Sulfatase_C
k59_669501_1	383372.Rcas_2336	9.05e-88	276.0	COG0367@1|root,COG0367@2|Bacteria,2G7R3@200795|Chloroflexi	200795|Chloroflexi	F	TIGRFAM asparagine synthase (glutamine-hydrolyzing)	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
k59_947462_2	926569.ANT_11760	9.64e-29	113.0	COG0697@1|root,COG0697@2|Bacteria	2|Bacteria	EG	spore germination	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_780635_1	246194.CHY_1547	1.84e-68	232.0	COG3829@1|root,COG4624@1|root,COG3829@2|Bacteria,COG4624@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia,42F02@68295|Thermoanaerobacterales	186801|Clostridia	K	transcriptional regulator	-	-	-	ko:K03721	-	-	-	-	ko00000,ko03000	-	-	-	FeS,Fe_hyd_lg_C,Fer4,HTH_8,PAS,PAS_4,PAS_9,PTS-HPr,Sigma54_activat
k59_57963_2	2880.D8LDV5	1.59e-36	136.0	COG3491@1|root,KOG0143@2759|Eukaryota	2759|Eukaryota	V	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy,DIOX_N
k59_558179_1	1126627.BAWE01000006_gene6551	3.3e-80	262.0	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,2TRGS@28211|Alphaproteobacteria,3JXXJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	FAD dependent oxidoreductase	sardh	-	1.5.3.19	ko:K19191	ko00760,ko01120,map00760,map01120	-	R10102	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO,FAO_M,GCV_T,GCV_T_C
k59_57967_1	795359.TOPB45_1259	6.16e-24	100.0	COG0518@1|root,COG0518@2|Bacteria,2GHWA@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	F	Glutamine amidotransferase class-I	-	-	-	-	-	-	-	-	-	-	-	-	GATase
k59_1725715_2	32057.KB217478_gene958	1.91e-14	79.7	2AQRE@1|root,31FZ6@2|Bacteria,1G7D6@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_613848_1	1123376.AUIU01000012_gene1512	4.53e-62	214.0	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,3J0TJ@40117|Nitrospirae	40117|Nitrospirae	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C,GATase_5
k59_836230_1	926569.ANT_10870	6.18e-67	227.0	COG0188@1|root,COG0188@2|Bacteria,2G5Q2@200795|Chloroflexi	200795|Chloroflexi	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_1558986_2	138119.DSY0400	1.1e-25	108.0	COG0526@1|root,COG0526@2|Bacteria,1TRBZ@1239|Firmicutes,249GQ@186801|Clostridia,264DZ@186807|Peptococcaceae	186801|Clostridia	CO	Arylsulfotransferase (ASST)	-	-	-	-	-	-	-	-	-	-	-	-	Arylsulfotran_2,Arylsulfotrans,Thioredoxin
k59_224710_1	675635.Psed_4593	2.37e-93	292.0	COG1053@1|root,COG1053@2|Bacteria,2GJ45@201174|Actinobacteria,4DZFB@85010|Pseudonocardiales	201174|Actinobacteria	C	Fumarate reductase flavoprotein C-term	sdhA	-	1.3.5.1,1.3.5.4,1.4.3.16	ko:K00239,ko:K00278	ko00020,ko00190,ko00250,ko00650,ko00720,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00250,map00650,map00720,map00760,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00115,M00149,M00173,M00374,M00376	R00357,R00481,R02164	RC00006,RC00045,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_2460_1	1463855.JOHV01000051_gene3455	1.04e-13	75.1	COG1744@1|root,COG1744@2|Bacteria,2GMFS@201174|Actinobacteria	201174|Actinobacteria	S	basic membrane	-	-	-	ko:K07335	-	-	-	-	ko00000	-	-	-	Bmp
k59_1003118_1	234267.Acid_1052	1.45e-12	65.1	COG1695@1|root,COG1695@2|Bacteria,3Y5ZC@57723|Acidobacteria	57723|Acidobacteria	K	transcriptional regulator PadR family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
k59_335836_1	1121430.JMLG01000002_gene1019	8.31e-23	101.0	COG0477@1|root,COG2814@2|Bacteria,1TRUT@1239|Firmicutes,25E84@186801|Clostridia,260VE@186807|Peptococcaceae	186801|Clostridia	EGP	PFAM Bacterial protein of	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
k59_1614521_2	675635.Psed_2086	9.34e-46	154.0	COG4577@1|root,COG4577@2|Bacteria,2HX34@201174|Actinobacteria	201174|Actinobacteria	CQ	BMC	-	-	-	-	-	-	-	-	-	-	-	-	BMC
k59_1169856_1	935863.AWZR01000003_gene2778	1.06e-126	384.0	COG1472@1|root,COG1472@2|Bacteria,1MVIV@1224|Proteobacteria,1RMA0@1236|Gammaproteobacteria,1X4AX@135614|Xanthomonadales	135614|Xanthomonadales	G	Belongs to the glycosyl hydrolase 3 family	bglX	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
k59_947536_1	1380387.JADM01000002_gene2321	3.46e-27	111.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,1RN5K@1236|Gammaproteobacteria,1XHSR@135619|Oceanospirillales	135619|Oceanospirillales	MU	Outer membrane efflux protein	-	-	-	ko:K18300	-	M00641	-	-	ko00000,ko00002,ko01504,ko02000	1.B.17	-	-	OEP
k59_1559013_1	1121481.AUAS01000001_gene4582	1.12e-09	62.0	COG0845@1|root,COG0845@2|Bacteria,4NFT4@976|Bacteroidetes,47JF4@768503|Cytophagia	976|Bacteroidetes	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_D23,OEP
k59_1559013_2	1379270.AUXF01000005_gene459	2.91e-24	108.0	COG1538@1|root,COG1538@2|Bacteria,1ZSMB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	MU	Outer membrane efflux protein	-	-	-	ko:K12340	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	1.B.17,2.A.6.2	-	-	OEP
k59_113563_1	675812.VHA_003490	3.2e-19	90.5	COG1752@1|root,COG1752@2|Bacteria,1PDQ2@1224|Proteobacteria,1RMWI@1236|Gammaproteobacteria,1XVKQ@135623|Vibrionales	135623|Vibrionales	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
k59_1725768_1	1380394.JADL01000018_gene1923	7.33e-90	267.0	COG1765@1|root,COG1765@2|Bacteria,1MWPR@1224|Proteobacteria,2U1VW@28211|Alphaproteobacteria,2JUAQ@204441|Rhodospirillales	204441|Rhodospirillales	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
k59_613893_1	999541.bgla_2g09690	4.28e-59	206.0	COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,2VI8X@28216|Betaproteobacteria,1K1W4@119060|Burkholderiaceae	28216|Betaproteobacteria	L	DEAD DEAH box helicase domain protein	lhr	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
k59_725248_1	1121324.CLIT_2c02200	6.06e-25	104.0	COG1180@1|root,COG1180@2|Bacteria,1TPK2@1239|Firmicutes,24871@186801|Clostridia	186801|Clostridia	C	glycyl-radical enzyme activating protein family	csdA	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4,Fer4_12,Radical_SAM
k59_725248_2	1304874.JAFY01000007_gene1686	2.37e-19	87.8	COG1882@1|root,COG1882@2|Bacteria,3T9PV@508458|Synergistetes	508458|Synergistetes	C	Pyruvate formate-lyase	-	-	2.3.1.54	ko:K00656	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
k59_58027_1	66373.JOFQ01000001_gene1793	0.000735	45.1	COG1917@1|root,COG1917@2|Bacteria,2I4M3@201174|Actinobacteria	201174|Actinobacteria	S	Cupin domain	-	-	-	ko:K14673	-	-	-	-	ko00000,ko01008	-	-	-	Cupin_2
k59_1171392_1	1123368.AUIS01000024_gene950	2.78e-66	214.0	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,1SYDD@1236|Gammaproteobacteria,2NCJF@225057|Acidithiobacillales	225057|Acidithiobacillales	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
k59_1171392_2	926550.CLDAP_07720	5.15e-08	54.7	COG0842@1|root,COG0842@2|Bacteria,2G6PG@200795|Chloroflexi	200795|Chloroflexi	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC2_membrane_3
k59_1616056_1	234267.Acid_2408	1.42e-31	128.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_782281_1	313606.M23134_00191	1.11e-10	62.8	COG3474@1|root,COG3474@2|Bacteria,4PKQA@976|Bacteroidetes,47XYT@768503|Cytophagia	976|Bacteroidetes	C	Cytochrome c7 and related cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrom_CIII,Cytochrome_C7
k59_504415_1	1267535.KB906767_gene2749	5.84e-75	233.0	COG3620@1|root,COG3620@2|Bacteria,3Y6X6@57723|Acidobacteria	57723|Acidobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
k59_782295_1	1210884.HG799463_gene9356	7.87e-44	163.0	COG3292@1|root,COG4191@1|root,COG3292@2|Bacteria,COG4191@2|Bacteria,2J2QP@203682|Planctomycetes	203682|Planctomycetes	T	Y_Y_Y domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,Reg_prop,Y_Y_Y
k59_949143_1	744980.TRICHSKD4_2206	1.85e-53	178.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Belongs to the thiolase family	phbA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_949143_2	78245.Xaut_3107	4.6e-28	107.0	COG1028@1|root,COG1028@2|Bacteria,1MUEV@1224|Proteobacteria,2TRCF@28211|Alphaproteobacteria,3EY5P@335928|Xanthobacteraceae	28211|Alphaproteobacteria	IQ	KR domain	phbB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.1.1.36	ko:K00023	ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200	M00373	R01779,R01977	RC00103,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	adh_short_C2
k59_1227460_1	765911.Thivi_0478	4.21e-97	291.0	COG3039@1|root,COG3039@2|Bacteria,1N88K@1224|Proteobacteria	1224|Proteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_3
k59_1116074_1	861299.J421_0637	1.37e-22	101.0	COG0577@1|root,COG0577@2|Bacteria	861299.J421_0637|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1060193_1	40373.F991_02412	7.51e-21	90.1	COG1714@1|root,COG1714@2|Bacteria,1MZAD@1224|Proteobacteria,1S6E9@1236|Gammaproteobacteria,3NNC2@468|Moraxellaceae	1236|Gammaproteobacteria	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	DUF4339,RDD
k59_726879_1	929703.KE386491_gene1519	2.37e-07	53.5	COG4888@1|root,COG4888@2|Bacteria,4NEE8@976|Bacteroidetes,47JJ5@768503|Cytophagia	976|Bacteroidetes	S	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
k59_726879_2	1297742.A176_04280	3.14e-24	103.0	COG2207@1|root,COG2207@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
k59_1171434_1	765123.HMPREF9621_00303	5.19e-44	150.0	COG0231@1|root,COG0231@2|Bacteria,2GJMS@201174|Actinobacteria,4DPJT@85009|Propionibacteriales	201174|Actinobacteria	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
k59_282087_1	96561.Dole_2444	0.000805	41.6	COG0758@1|root,COG1948@1|root,COG0758@2|Bacteria,COG1948@2|Bacteria,1MVF6@1224|Proteobacteria,42N10@68525|delta/epsilon subdivisions,2WJI9@28221|Deltaproteobacteria,2MHSD@213118|Desulfobacterales	28221|Deltaproteobacteria	LU	TIGRFAM DNA protecting protein DprA	dprA	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
k59_282087_2	502025.Hoch_4636	5.16e-51	181.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,42MM9@68525|delta/epsilon subdivisions,2WJTT@28221|Deltaproteobacteria,2YU14@29|Myxococcales	28221|Deltaproteobacteria	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
k59_59625_1	1173025.GEI7407_2204	2.39e-06	50.1	COG0045@1|root,COG1042@1|root,COG1670@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1670@2|Bacteria,1G2D3@1117|Cyanobacteria,1H81U@1150|Oscillatoriales	1117|Cyanobacteria	CJ	TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain	-	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
k59_1171444_1	760192.Halhy_6538	9.09e-47	171.0	COG4447@1|root,COG4447@2|Bacteria,4NESU@976|Bacteroidetes,1IUT7@117747|Sphingobacteriia	976|Bacteroidetes	S	Sortilin, neurotensin receptor 3,	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
k59_1727379_1	491952.Mar181_2588	9.08e-29	117.0	COG1600@1|root,COG1600@2|Bacteria,1MV1H@1224|Proteobacteria,1RMD9@1236|Gammaproteobacteria,1XHVG@135619|Oceanospirillales	135619|Oceanospirillales	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	queG	-	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Fer4_16
k59_393188_1	158500.BV97_05214	2.15e-65	211.0	COG1062@1|root,COG1062@2|Bacteria,1MUK4@1224|Proteobacteria,2TUMG@28211|Alphaproteobacteria,2K338@204457|Sphingomonadales	204457|Sphingomonadales	C	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.90	ko:K00055	ko00350,ko00360,ko00622,ko00623,ko01100,ko01120,ko01220,map00350,map00360,map00622,map00623,map01100,map01120,map01220	M00537,M00538	R01763,R02611,R04304,R05282,R05347,R05348	RC00087,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_1504912_1	530564.Psta_4166	1.31e-36	138.0	COG1519@1|root,COG1519@2|Bacteria,2IYCJ@203682|Planctomycetes	203682|Planctomycetes	M	transferase	-	-	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30	-	Glycos_transf_N
k59_949187_1	1347368.HG964404_gene5092	5.82e-15	76.6	COG1266@1|root,COG1266@2|Bacteria,1UUMR@1239|Firmicutes,4HDXH@91061|Bacilli,1ZCN4@1386|Bacillus	91061|Bacilli	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
k59_1171465_1	1144343.PMI41_01040	6.74e-97	294.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,2TQYV@28211|Alphaproteobacteria,43I2M@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	IQ	Belongs to the beta-ketoacyl-ACP synthases family	fabB	GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.41	ko:K00647	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_1616137_1	380703.AHA_0645	1.1e-07	53.1	COG0583@1|root,COG0583@2|Bacteria,1R79D@1224|Proteobacteria,1S0P7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Transcriptional regulator, LysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_1616137_2	999541.bgla_1g02650	1.28e-85	280.0	COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2VJGC@28216|Betaproteobacteria,1K37E@119060|Burkholderiaceae	28216|Betaproteobacteria	C	oxidoreductase	porG	-	1.2.7.8	ko:K04090	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR,TPP_enzyme_C
k59_115194_1	1004785.AMBLS11_18385	1.1e-45	155.0	COG0545@1|root,COG0545@2|Bacteria,1RDA1@1224|Proteobacteria,1RRKU@1236|Gammaproteobacteria,46CFF@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	Peptidyl-prolyl cis-trans	fkpA	-	5.2.1.8	ko:K03772	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C,FKBP_N
k59_393207_1	977880.RALTA_A3049	1.28e-40	137.0	2CNK3@1|root,32SH9@2|Bacteria,1N02U@1224|Proteobacteria,2VUNW@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of Unknown function (DUF2784)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2784
k59_1393716_1	1187851.A33M_3877	1.89e-72	233.0	COG0642@1|root,COG2205@2|Bacteria,1N9SU@1224|Proteobacteria,2TWD1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
k59_1403722_2	138119.DSY4378	3.67e-40	139.0	COG0262@1|root,COG0262@2|Bacteria,1VAUA@1239|Firmicutes,24G7Y@186801|Clostridia,263EC@186807|Peptococcaceae	186801|Clostridia	H	Dihydrofolate reductase	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
k59_292022_1	483219.LILAB_08375	1.83e-34	135.0	COG0823@1|root,COG1228@1|root,COG0823@2|Bacteria,COG1228@2|Bacteria,1MX3A@1224|Proteobacteria,438QJ@68525|delta/epsilon subdivisions,2X3XW@28221|Deltaproteobacteria,2YXIE@29|Myxococcales	28221|Deltaproteobacteria	QU	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,PD40
k59_1014945_2	1158292.JPOE01000002_gene3911	2.1e-34	131.0	COG3335@1|root,COG3335@2|Bacteria,1MW7X@1224|Proteobacteria,2VMDX@28216|Betaproteobacteria	28216|Betaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_23,HTH_32
k59_1459648_1	641107.CDLVIII_4821	7.23e-16	83.6	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,36DEY@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter transmembrane region	-	-	-	ko:K18889	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106.13,3.A.1.106.5	-	-	ABC_membrane,ABC_tran
k59_1238197_1	118173.KB235910_gene4327	9.5e-37	133.0	COG4974@1|root,COG4974@2|Bacteria,1G224@1117|Cyanobacteria,1H8SW@1150|Oscillatoriales	1117|Cyanobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
k59_1238197_2	1071679.BG57_05260	0.000857	43.5	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,2VHUC@28216|Betaproteobacteria,1K4YM@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
k59_124488_1	471223.GWCH70_0005	2.74e-31	123.0	COG0187@1|root,COG0187@2|Bacteria,1TQ0R@1239|Firmicutes,4H9Y6@91061|Bacilli,1WEPI@129337|Geobacillus	91061|Bacilli	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005575,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_847242_2	448385.sce7486	1.08e-18	82.0	COG3682@1|root,COG3682@2|Bacteria,1N3MZ@1224|Proteobacteria	1224|Proteobacteria	K	Penicillinase repressor	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
k59_1126379_1	37919.EP51_03445	1.56e-45	162.0	COG0654@1|root,COG0654@2|Bacteria,2GK7I@201174|Actinobacteria,4FU0V@85025|Nocardiaceae	201174|Actinobacteria	CH	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
k59_1625529_1	1249627.D779_2908	2.98e-09	58.9	COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,1RP6X@1236|Gammaproteobacteria,1WWZ7@135613|Chromatiales	135613|Chromatiales	O	PFAM peptidase	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_U32
k59_1625529_2	1121468.AUBR01000012_gene2591	7.38e-43	151.0	COG0826@1|root,COG0826@2|Bacteria	2|Bacteria	O	peptidase U32	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_U32
k59_1514864_1	388051.AUFE01000036_gene4072	2.3e-85	265.0	COG3119@1|root,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,2VNBG@28216|Betaproteobacteria,1K297@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Pfam Sulfatase	-	-	3.1.6.6	ko:K01133	-	-	-	-	ko00000,ko01000	-	-	-	DUF4976,Sulfatase
k59_1292317_1	243231.GSU1223	1.99e-33	124.0	29FVD@1|root,302T2@2|Bacteria,1RKWC@1224|Proteobacteria,42TAZ@68525|delta/epsilon subdivisions,2WP8E@28221|Deltaproteobacteria,43T6K@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1292317_2	383372.Rcas_1195	6.51e-11	63.9	COG1366@1|root,COG2172@1|root,COG1366@2|Bacteria,COG2172@2|Bacteria,2G93H@200795|Chloroflexi,375J3@32061|Chloroflexia	32061|Chloroflexia	T	PFAM Sulfate transporter antisigma-factor antagonist STAS	-	-	2.7.11.1	ko:K04749,ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c_2,STAS
k59_1181357_1	671143.DAMO_0820	1.7e-41	139.0	COG0723@1|root,COG0723@2|Bacteria,2NQ46@2323|unclassified Bacteria	2|Bacteria	C	Rieske [2Fe-2S] domain	petA	-	1.10.2.2,1.10.9.1	ko:K00411,ko:K02636,ko:K03886	ko00190,ko00195,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map00195,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152,M00162	R03817,R08409	RC01002	ko00000,ko00001,ko00002,ko00194,ko01000	-	-	iAF987.Gmet_1922	CytB6-F_Fe-S,Rieske,UCR_Fe-S_N
k59_1181357_2	1379698.RBG1_1C00001G0780	3.82e-55	183.0	COG1290@1|root,COG1290@2|Bacteria,2NP8C@2323|unclassified Bacteria	2|Bacteria	C	Cytochrome b(N-terminal)/b6/petB	petB	-	-	ko:K00410,ko:K00412,ko:K02635,ko:K02637	ko00190,ko00195,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map00195,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152,M00162	-	-	ko00000,ko00001,ko00002,ko00194,ko03029	-	-	-	Cytochrom_B_C,Cytochrom_C1,Cytochrome_B
k59_459127_1	589865.DaAHT2_0483	4.7e-50	174.0	COG5433@1|root,COG5433@2|Bacteria,1MXI8@1224|Proteobacteria,42WFU@68525|delta/epsilon subdivisions,2WS4T@28221|Deltaproteobacteria,2MKX1@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Pfam Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_792507_1	195253.Syn6312_3679	6.12e-27	113.0	COG1472@1|root,COG1472@2|Bacteria,1G29F@1117|Cyanobacteria,1GYQ1@1129|Synechococcus	1117|Cyanobacteria	G	Glycosyl hydrolase family 3	bgl	-	3.2.1.21,3.2.1.52	ko:K01207,ko:K05349	ko00460,ko00500,ko00520,ko00531,ko00940,ko01100,ko01110,ko01501,map00460,map00500,map00520,map00531,map00940,map01100,map01110,map01501	M00628	R00022,R00026,R02558,R02887,R02985,R03527,R04949,R04998,R05963,R07809,R07810,R10035,R10039,R10040,R10831	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko00002,ko01000	-	GH3	-	Glyco_hydro_3
k59_904002_1	994479.GL877879_gene4459	3.56e-72	241.0	COG0542@1|root,COG0542@2|Bacteria,2GJ77@201174|Actinobacteria,4DXTY@85010|Pseudonocardiales	201174|Actinobacteria	O	with chaperone activity, ATP-binding subunit	clpC	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
k59_69363_1	928724.SacglDRAFT_03472	1.69e-60	199.0	COG0053@1|root,COG0053@2|Bacteria,2GKSG@201174|Actinobacteria,4DYCH@85010|Pseudonocardiales	201174|Actinobacteria	P	cation diffusion facilitator family transporter	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
k59_1514899_1	189426.PODO_07850	4.17e-102	311.0	COG3534@1|root,COG3534@2|Bacteria,1TR7B@1239|Firmicutes,4HCUX@91061|Bacilli,26RY2@186822|Paenibacillaceae	91061|Bacilli	G	alpha-N-arabinofuranosidase	-	-	3.2.1.55	ko:K01209	ko00520,map00520	-	R01762	-	ko00000,ko00001,ko01000	-	GH51	-	Alpha-L-AF_C
k59_124546_1	1028800.RG540_PA10390	6.02e-119	347.0	COG3293@1|root,COG3293@2|Bacteria,1PVIT@1224|Proteobacteria,2TURP@28211|Alphaproteobacteria,4BDDJ@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Transposase DDE domain	-	-	-	ko:K07492	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
k59_1238264_1	570967.JMLV01000001_gene2825	5.37e-83	254.0	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,2TSDS@28211|Alphaproteobacteria,2JQSZ@204441|Rhodospirillales	204441|Rhodospirillales	E	Belongs to the binding-protein-dependent transport system permease family	livH	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_459176_1	1122132.AQYH01000018_gene1165	6.13e-55	185.0	COG0477@1|root,COG2814@2|Bacteria,1MUDA@1224|Proteobacteria,2TS0P@28211|Alphaproteobacteria,4B8FJ@82115|Rhizobiaceae	28211|Alphaproteobacteria	EGP	Major facilitator superfamily	hsrA	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_681622_1	1298858.AUEL01000019_gene3260	3.66e-44	163.0	COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DZR,Guanylate_cyc
k59_1737194_1	391624.OIHEL45_07055	1.27e-58	192.0	COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,2TS46@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component	-	-	-	ko:K21395	-	-	-	-	ko00000,ko02000	2.A.56.1	-	-	DctP
k59_292120_1	243924.LT42_22135	8.43e-18	84.0	COG1057@1|root,COG1057@2|Bacteria,1RD0J@1224|Proteobacteria,1RP00@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034355,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043094,GO:0043173,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.7.7.18,3.5.4.4	ko:K00969,ko:K01488	ko00230,ko00760,ko01100,ko05340,map00230,map00760,map01100,map05340	M00115	R00137,R01560,R02556,R03005	RC00002,RC00477	ko00000,ko00001,ko00002,ko01000	-	-	iECUMN_1333.ECUMN_0733,iJN746.PP_4810,iPC815.YPO2607,iSbBS512_1146.SbBS512_E0612	CTP_transf_like
k59_292120_2	102125.Xen7305DRAFT_00023410	4.69e-21	88.6	COG0799@1|root,COG0799@2|Bacteria,1G6IA@1117|Cyanobacteria,3VJZA@52604|Pleurocapsales	1117|Cyanobacteria	J	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	GO:0003674,GO:0005488,GO:0006417,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043023,GO:0044087,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:0090069,GO:0090071,GO:2000112,GO:2000113	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
k59_1570571_1	765420.OSCT_3124	4.91e-46	164.0	COG1207@1|root,COG1207@2|Bacteria,2GBS0@200795|Chloroflexi,376CX@32061|Chloroflexia	32061|Chloroflexia	M	Sugar nucleotidyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_4
k59_69414_1	1123279.ATUS01000002_gene224	3.02e-96	296.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMIW@1236|Gammaproteobacteria,1J5GF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	COG1530 Ribonucleases G and E	rng	GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005856,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008996,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360	-	ko:K08301	-	-	-	-	ko00000,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
k59_292136_1	326427.Cagg_3098	2.48e-34	128.0	COG3694@1|root,COG3694@2|Bacteria,2G90J@200795|Chloroflexi,377JE@32061|Chloroflexia	32061|Chloroflexia	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_6
k59_124584_1	1033802.SSPSH_001948	5.57e-21	95.1	COG1793@1|root,COG1793@2|Bacteria,1NTIR@1224|Proteobacteria	1224|Proteobacteria	L	DNA ligase	ligD	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
k59_1238320_1	1232410.KI421421_gene3688	1.86e-25	108.0	COG1030@1|root,COG1030@2|Bacteria,1MUJN@1224|Proteobacteria,42MWM@68525|delta/epsilon subdivisions,2WK3H@28221|Deltaproteobacteria,43SBZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	NfeD-like C-terminal, partner-binding	nfeD	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	CLP_protease,NfeD,SDH_sah
k59_1625626_1	871968.DESME_03155	4.68e-31	115.0	COG3153@1|root,COG3153@2|Bacteria	2|Bacteria	S	transferase activity, transferring acyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
k59_683456_2	933262.AXAM01000019_gene1114	1.85e-31	124.0	COG5598@1|root,COG5598@2|Bacteria,1MWJN@1224|Proteobacteria,42Q8R@68525|delta/epsilon subdivisions,2WMDK@28221|Deltaproteobacteria,2MJEG@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Trimethylamine methyltransferase	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
k59_1461350_1	1379270.AUXF01000007_gene888	4.28e-72	232.0	COG2355@1|root,COG2355@2|Bacteria,1ZT5A@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Membrane dipeptidase (Peptidase family M19)	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
k59_1738890_1	595460.RRSWK_00666	4.69e-28	117.0	COG0457@1|root,COG0457@2|Bacteria,2IXP3@203682|Planctomycetes	203682|Planctomycetes	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,TPR_16
k59_1128176_1	652103.Rpdx1_0143	8.86e-45	156.0	COG1960@1|root,COG1960@2|Bacteria,1MW0F@1224|Proteobacteria,2TR9I@28211|Alphaproteobacteria,3JUIJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	acyl-CoA dehydrogenase	MA20_40060	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_571108_1	926569.ANT_12110	1.06e-33	132.0	COG0739@1|root,COG1388@1|root,COG0739@2|Bacteria,COG1388@2|Bacteria	2|Bacteria	M	LysM domain	-	-	2.7.7.6	ko:K03046,ko:K03641,ko:K08642	ko00230,ko00240,ko01100,ko02024,ko03020,map00230,map00240,map01100,map02024,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko01002,ko02000,ko03021,ko03400	2.C.1.2	-	-	Glyco_hydro_18,LysM,OapA,PD40,Peptidase_M23
k59_1016705_1	1348657.M622_08835	8.34e-45	166.0	COG1305@1|root,COG1305@2|Bacteria,1MWCE@1224|Proteobacteria,2VHZP@28216|Betaproteobacteria,2KV42@206389|Rhodocyclales	206389|Rhodocyclales	E	Domain of unknown function (DUF3488)	-	-	2.3.2.13	ko:K22452	-	-	-	-	ko00000,ko01000	-	-	-	DUF3488,DUF4129,Transglut_core
k59_404836_1	671143.DAMO_2755	2.6e-97	304.0	COG0568@1|root,COG0568@2|Bacteria,2NNY9@2323|unclassified Bacteria	2|Bacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	rpoD	GO:0000988,GO:0000990,GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043254,GO:0044087,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2000142,GO:2001141	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_1128214_1	472175.EL18_02221	8.71e-107	325.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,2TSCY@28211|Alphaproteobacteria,43IPA@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Asparagine synthase	asnO	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
k59_738703_1	349163.Acry_0885	6.41e-18	90.5	COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,2TT8A@28211|Alphaproteobacteria,2JQ61@204441|Rhodospirillales	204441|Rhodospirillales	NU	Bacterial type II and III secretion system protein	-	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Secretin,Secretin_N
k59_1683374_1	69279.BG36_03335	4.28e-19	87.4	COG0483@1|root,COG0483@2|Bacteria,1MV4W@1224|Proteobacteria,2TV4R@28211|Alphaproteobacteria,43J3M@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	Inositol monophosphatase	suhB2	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
k59_71081_2	298654.FraEuI1c_2811	1.89e-32	126.0	COG2159@1|root,COG2159@2|Bacteria,2GKG2@201174|Actinobacteria	201174|Actinobacteria	S	Pfam Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
k59_1071815_1	671143.DAMO_2996	4.21e-81	262.0	COG1032@1|root,COG1032@2|Bacteria,2NQU0@2323|unclassified Bacteria	2|Bacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
k59_182042_1	1379281.AVAG01000033_gene486	4.49e-55	186.0	COG0336@1|root,COG4752@1|root,COG0336@2|Bacteria,COG4752@2|Bacteria,1MUN1@1224|Proteobacteria,42P8R@68525|delta/epsilon subdivisions,2WKIR@28221|Deltaproteobacteria,2M7Y5@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	Belongs to the RNA methyltransferase TrmD family	trmD	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	Methyltrn_RNA_4,tRNA_m1G_MT
k59_238268_1	987059.RBXJA2T_08200	9.41e-79	251.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2VI6G@28216|Betaproteobacteria,1KIY6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Dehydrogenase	lpdA	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim
k59_15838_1	1123024.AUII01000006_gene4636	1.23e-106	340.0	COG3696@1|root,COG3696@2|Bacteria,2I53X@201174|Actinobacteria,4EE9U@85010|Pseudonocardiales	201174|Actinobacteria	P	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_461075_1	13689.BV96_00152	2.65e-16	81.3	COG2175@1|root,COG2175@2|Bacteria,1Q8GY@1224|Proteobacteria,2UPI4@28211|Alphaproteobacteria,2K930@204457|Sphingomonadales	204457|Sphingomonadales	Q	Taurine catabolism dioxygenase TauD, TfdA family	-	-	-	-	-	-	-	-	-	-	-	-	TauD
k59_1738957_1	1385517.N800_13355	1.52e-70	234.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1X3GA@135614|Xanthomonadales	135614|Xanthomonadales	P	Heavy metal translocating P-type atpase	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
k59_1240135_1	1265502.KB905930_gene1414	2.77e-57	187.0	COG1285@1|root,COG1285@2|Bacteria,1MURJ@1224|Proteobacteria,2WA1J@28216|Betaproteobacteria,4AFHN@80864|Comamonadaceae	28216|Betaproteobacteria	S	MgtC family	-	-	-	ko:K07507	-	-	-	-	ko00000,ko02000	9.B.20	-	-	MgtC
k59_794283_1	1047013.AQSP01000138_gene1051	1.56e-28	114.0	COG0438@1|root,COG0438@2|Bacteria,2NPA0@2323|unclassified Bacteria	2|Bacteria	M	glycosyl transferase group 1	-	-	-	ko:K00754	-	-	-	-	ko00000,ko01000	-	GT4	-	Glyco_transf_4,Glycos_transf_1
k59_348733_1	926550.CLDAP_10580	1.42e-29	119.0	COG3336@1|root,COG3336@2|Bacteria,2G725@200795|Chloroflexi	200795|Chloroflexi	C	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG)	-	-	-	-	-	-	-	-	-	-	-	-	Caa3_CtaG
k59_404881_1	566466.NOR53_824	2.39e-34	134.0	COG4447@1|root,COG4447@2|Bacteria,1R6KJ@1224|Proteobacteria	1224|Proteobacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
k59_238300_1	113395.AXAI01000011_gene6399	1.87e-60	197.0	COG0500@1|root,COG2226@2|Bacteria,1PE78@1224|Proteobacteria,2V82K@28211|Alphaproteobacteria,3K5JW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_960771_1	1448857.JFAP01000007_gene243	1.4e-13	77.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,42MNF@68525|delta/epsilon subdivisions,2YMW2@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	M	peptidase M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_1683425_1	196162.Noca_2936	1.05e-21	96.3	COG0659@1|root,COG0659@2|Bacteria,2GJCB@201174|Actinobacteria,4DP1B@85009|Propionibacteriales	201174|Actinobacteria	P	Sulfate permease family	-	-	-	-	-	-	-	-	-	-	-	-	STAS,Sulfate_transp
k59_1683425_2	360911.EAT1b_1852	8.65e-20	89.0	COG1253@1|root,COG1253@2|Bacteria,1UJRK@1239|Firmicutes,4ITEH@91061|Bacilli	91061|Bacilli	S	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_293795_1	314345.SPV1_09088	5.75e-33	131.0	COG0569@1|root,COG1226@1|root,COG0569@2|Bacteria,COG1226@2|Bacteria,1MU1R@1224|Proteobacteria	1224|Proteobacteria	P	TrkA-N domain protein	kch	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2,TrkA_N
k59_848994_1	1198114.AciX9_2007	2.03e-135	393.0	COG2826@1|root,COG2826@2|Bacteria,3Y896@57723|Acidobacteria,2JN59@204432|Acidobacteriia	204432|Acidobacteriia	L	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_38,rve
k59_1683437_1	1242864.D187_002408	1.05e-05	54.3	COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,42PHP@68525|delta/epsilon subdivisions,2WIXN@28221|Deltaproteobacteria,2YU93@29|Myxococcales	28221|Deltaproteobacteria	U	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40
k59_683572_1	411902.CLOBOL_01836	1.15e-21	99.4	COG2812@1|root,COG2812@2|Bacteria,1VCQC@1239|Firmicutes,248U4@186801|Clostridia,21YAE@1506553|Lachnoclostridium	186801|Clostridia	L	DNA polymerase III	holB	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNApol3-delta_C
k59_1405715_1	1248916.ANFY01000020_gene1621	5.67e-39	142.0	COG0583@1|root,COG0583@2|Bacteria,1MXRP@1224|Proteobacteria,2TRVK@28211|Alphaproteobacteria,2K2UE@204457|Sphingomonadales	204457|Sphingomonadales	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_794325_1	1499967.BAYZ01000141_gene6153	8.23e-20	94.7	COG1262@1|root,COG1262@2|Bacteria,2NR84@2323|unclassified Bacteria	2|Bacteria	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,PEGA,Peptidase_C14,Pkinase
k59_1739006_1	1004785.AMBLS11_10530	2.85e-28	115.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,464D9@72275|Alteromonadaceae	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	mdtB	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_1128297_1	266265.Bxe_C0490	4.98e-36	134.0	COG3547@1|root,COG3547@2|Bacteria,1MW0N@1224|Proteobacteria,2VWYN@28216|Betaproteobacteria,1K8UX@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Transposase IS116/IS110/IS902 family	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	Transposase_20
k59_293812_1	1487921.DP68_14725	1.75e-61	203.0	COG3328@1|root,COG3328@2|Bacteria,1TP4C@1239|Firmicutes,248UI@186801|Clostridia,36GDB@31979|Clostridiaceae	186801|Clostridia	L	PFAM transposase, mutator	-	-	-	ko:K07493	-	-	-	-	ko00000	-	-	-	Transposase_mut
k59_683587_1	1267211.KI669560_gene2433	1.64e-29	116.0	COG0673@1|root,COG0673@2|Bacteria,4NJ92@976|Bacteroidetes,1ISF7@117747|Sphingobacteriia	976|Bacteroidetes	S	Oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_683587_2	926550.CLDAP_29730	1.5e-45	155.0	COG4821@1|root,COG4821@2|Bacteria,2G6XP@200795|Chloroflexi	200795|Chloroflexi	S	SIS domain	-	-	-	-	-	-	-	-	-	-	-	-	SIS_2
k59_960803_1	266117.Rxyl_2557	4.34e-11	63.5	COG0372@1|root,COG0372@2|Bacteria,2GKST@201174|Actinobacteria,4CPP8@84995|Rubrobacteria	84995|Rubrobacteria	C	Citrate synthase, C-terminal domain	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
k59_1240203_1	1114856.C496_16527	1.04e-22	103.0	COG1782@1|root,arCOG00543@2157|Archaea,2XTIM@28890|Euryarchaeota,23TDK@183963|Halobacteria	183963|Halobacteria	S	metal-dependent RNase, consists of a metallo-beta-lactamase domain and an RNA-binding KH domain	-	-	-	-	-	-	-	-	-	-	-	-	Beta-Casp,KH_7,RMMBL
k59_1308533_1	1122915.AUGY01000008_gene5146	2.39e-12	75.1	COG3250@1|root,COG3250@2|Bacteria,1TPK7@1239|Firmicutes,4HBHM@91061|Bacilli,26SJK@186822|Paenibacillaceae	91061|Bacilli	G	Belongs to the glycosyl hydrolase 2 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
k59_195692_1	406817.XNC1_2040	1.41e-21	98.6	COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,1RPAG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	COG1020 Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
k59_1585922_1	211165.AJLN01000061_gene3947	1.51e-92	280.0	COG0346@1|root,COG0346@2|Bacteria,1G29P@1117|Cyanobacteria,1JK2A@1189|Stigonemataceae	1117|Cyanobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
k59_1031564_1	880073.Calab_0082	1.04e-18	86.3	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_475607_1	545694.TREPR_0455	2.2e-32	122.0	COG0705@1|root,COG0705@2|Bacteria,2J7HV@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
k59_1031586_1	671143.DAMO_2345	5.74e-95	286.0	COG0451@1|root,COG0451@2|Bacteria,2NNT0@2323|unclassified Bacteria	2|Bacteria	M	Polysaccharide biosynthesis protein	lspL	-	5.1.3.6	ko:K08679	ko00520,ko01100,map00520,map01100	-	R01385	RC00289	ko00000,ko00001,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
k59_1141828_2	883080.HMPREF9697_02697	3.61e-41	143.0	COG0284@1|root,COG0284@2|Bacteria,1MW2C@1224|Proteobacteria,2TTB3@28211|Alphaproteobacteria,3JTIS@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	F	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)	pyrF	GO:0003674,GO:0003824,GO:0004590,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
k59_418448_1	871963.Desdi_0426	3.66e-41	139.0	COG0222@1|root,COG0222@2|Bacteria,1V6EI@1239|Firmicutes,24JAC@186801|Clostridia,26263@186807|Peptococcaceae	186801|Clostridia	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	-	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
k59_251135_1	479434.Sthe_1091	1.55e-56	195.0	COG0296@1|root,COG0296@2|Bacteria,2G5IR@200795|Chloroflexi,27XZS@189775|Thermomicrobia	189775|Thermomicrobia	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
k59_195730_1	138119.DSY4803	1.36e-41	153.0	COG2204@1|root,COG2204@2|Bacteria,1VSKG@1239|Firmicutes,24ZP4@186801|Clostridia,2642K@186807|Peptococcaceae	186801|Clostridia	T	Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains	-	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_475635_1	1379270.AUXF01000002_gene1585	1.49e-25	110.0	COG0515@1|root,COG0515@2|Bacteria,1ZUMJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
k59_1697964_1	292459.STH3249	1.23e-26	109.0	COG0030@1|root,COG0030@2|Bacteria,1TP9W@1239|Firmicutes,248RY@186801|Clostridia	186801|Clostridia	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
k59_584401_1	1238182.C882_2513	1.31e-71	220.0	COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,2U797@28211|Alphaproteobacteria,2JS8N@204441|Rhodospirillales	204441|Rhodospirillales	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
k59_29250_1	1385935.N836_18470	1.92e-49	167.0	2DBFF@1|root,2Z8YA@2|Bacteria,1G2KB@1117|Cyanobacteria,1HFHB@1150|Oscillatoriales	1117|Cyanobacteria	L	Helix-turn-helix of DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_4,HTH_Tnp_4
k59_697162_1	1121878.AUGL01000006_gene676	4.06e-49	176.0	COG1262@1|root,COG1262@2|Bacteria,1MUNC@1224|Proteobacteria,1RQI4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	methyltransferase	sumf2	-	-	-	-	-	-	-	-	-	-	-	DinB_2,FGE-sulfatase,Methyltransf_11,Methyltransf_12,Methyltransf_23,Methyltransf_25,Methyltransf_31
k59_920756_1	1347392.CCEZ01000044_gene601	7.84e-38	131.0	COG0222@1|root,COG0222@2|Bacteria,1V6EI@1239|Firmicutes,24JAC@186801|Clostridia,36IQP@31979|Clostridiaceae	186801|Clostridia	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	-	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
k59_1418814_1	1463845.JOIG01000003_gene4651	2.09e-23	102.0	COG0515@1|root,COG0515@2|Bacteria,2IDTA@201174|Actinobacteria	201174|Actinobacteria	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
k59_639827_1	864073.HFRIS_002339	3.37e-40	154.0	COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,2VKDG@28216|Betaproteobacteria,472GN@75682|Oxalobacteraceae	28216|Betaproteobacteria	G	Glycosyl hydrolase 36 superfamily, catalytic domain	-	-	-	ko:K13688	-	-	-	-	ko00000,ko01000,ko01003	-	GH94,GT84	-	Glyco_hydro_36,Glyco_transf_36,Glycoamylase
k59_84859_1	44689.DDB0233947	7.09e-31	124.0	COG0365@1|root,KOG1175@2759|Eukaryota,3XF64@554915|Amoebozoa	554915|Amoebozoa	I	AMP-binding enzyme C-terminal domain	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_1697998_1	1307761.L21SP2_1483	1.51e-61	197.0	COG3638@1|root,COG3638@2|Bacteria,2J6UW@203691|Spirochaetes	203691|Spirochaetes	P	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system	phnC	-	3.6.3.28	ko:K02041	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.9	-	-	ABC_tran
k59_139806_1	240016.ABIZ01000001_gene5712	1.01e-53	189.0	COG2114@1|root,COG3903@1|root,COG2114@2|Bacteria,COG3903@2|Bacteria,46TZ3@74201|Verrucomicrobia	74201|Verrucomicrobia	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,NB-ARC
k59_1031688_1	768671.ThimaDRAFT_0300	1.69e-34	136.0	COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,1RNE4@1236|Gammaproteobacteria,1WW0B@135613|Chromatiales	135613|Chromatiales	P	Acts as a magnesium transporter	-	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
k59_975287_1	1496688.ER33_11555	2.77e-66	222.0	COG3408@1|root,COG3408@2|Bacteria,1G2AS@1117|Cyanobacteria,22THV@167375|Cyanobium	1117|Cyanobacteria	G	Amylo-alpha-1,6-glucosidase	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N
k59_1530146_1	1121440.AUMA01000010_gene386	4.35e-16	84.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,42MFK@68525|delta/epsilon subdivisions,2WKBU@28221|Deltaproteobacteria,2M7XJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	extracellular solute-binding protein, family 5	-	-	-	ko:K02035,ko:K13893	ko02010,ko02024,map02010,map02024	M00239,M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.21,3.A.1.5.24	-	-	SBP_bac_5
k59_1751862_1	1435356.Y013_24500	7.07e-15	77.4	COG0491@1|root,COG0491@2|Bacteria,2GMDD@201174|Actinobacteria,4FZD4@85025|Nocardiaceae	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_641279_1	765913.ThidrDRAFT_3310	1.76e-68	225.0	COG0318@1|root,COG0318@2|Bacteria,1MXPB@1224|Proteobacteria,1RRD5@1236|Gammaproteobacteria,1WW42@135613|Chromatiales	135613|Chromatiales	IQ	AMP-binding enzyme	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
k59_641279_2	1249627.D779_0376	8.72e-10	55.5	COG0764@1|root,COG0764@2|Bacteria,1NGGK@1224|Proteobacteria,1SJ6T@1236|Gammaproteobacteria,1WZPT@135613|Chromatiales	135613|Chromatiales	I	FabA-like domain	-	-	-	-	-	-	-	-	-	-	-	-	FabA
k59_252702_1	1379698.RBG1_1C00001G0513	3.23e-51	176.0	COG0119@1|root,COG0119@2|Bacteria,2NNNZ@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA3	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
k59_1420575_1	1123013.AUIC01000003_gene658	4.16e-14	77.8	COG1316@1|root,COG1316@2|Bacteria,2GM55@201174|Actinobacteria,4FKR4@85023|Microbacteriaceae	201174|Actinobacteria	K	Cell envelope-related transcriptional attenuator domain	-	-	-	-	-	-	-	-	-	-	-	-	LytR_cpsA_psr
k59_197012_1	1521187.JPIM01000008_gene2107	1.26e-74	245.0	COG1449@1|root,COG1449@2|Bacteria,2G5XB@200795|Chloroflexi,3768X@32061|Chloroflexia	32061|Chloroflexia	G	Belongs to the glycosyl hydrolase 57 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF3536,Glyco_hydro_57
k59_1476881_1	366602.Caul_3292	8.47e-49	172.0	COG3185@1|root,COG3185@2|Bacteria,1MVR0@1224|Proteobacteria,2TTAD@28211|Alphaproteobacteria,2KIHE@204458|Caulobacterales	204458|Caulobacterales	E	Pfam:DUF1446	-	-	-	-	-	-	-	-	-	-	-	-	AtuA
k59_922606_1	1121957.ATVL01000009_gene1204	1.07e-23	102.0	COG2318@1|root,COG2382@1|root,COG2318@2|Bacteria,COG2382@2|Bacteria,4NI86@976|Bacteroidetes,47NJ2@768503|Cytophagia	976|Bacteroidetes	P	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
k59_531191_1	981369.JQMJ01000004_gene2626	3.34e-35	136.0	COG0121@1|root,COG4301@1|root,COG0121@2|Bacteria,COG4301@2|Bacteria,2GJAX@201174|Actinobacteria,2NGCU@228398|Streptacidiphilus	201174|Actinobacteria	S	Histidine-specific methyltransferase, SAM-dependent	egtD	-	2.1.1.44	ko:K18911	ko00340,map00340	-	R01169	RC00003,RC02308	ko00000,ko00001,ko01000	-	-	-	GATase_6,Methyltransf_33
k59_1198361_1	640081.Dsui_1300	1.64e-101	301.0	COG2041@1|root,COG2041@2|Bacteria,1MUW0@1224|Proteobacteria,2VH08@28216|Betaproteobacteria,2KV6B@206389|Rhodocyclales	206389|Rhodocyclales	C	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide	msrP	-	-	ko:K07147	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_molyb
k59_1365489_1	1133849.O3I_001110	7.54e-21	91.7	COG2128@1|root,COG2128@2|Bacteria,2ICVV@201174|Actinobacteria,4FZFJ@85025|Nocardiaceae	201174|Actinobacteria	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
k59_1255754_1	85681.XP_006433531.1	1.92e-39	147.0	COG0466@1|root,KOG2004@2759|Eukaryota,37IS1@33090|Viridiplantae,3G769@35493|Streptophyta	35493|Streptophyta	O	ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner	-	GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006508,GO:0006515,GO:0006807,GO:0006996,GO:0007005,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009507,GO:0009536,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0031974,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0051603,GO:0070011,GO:0070013,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	3.4.21.53	ko:K08675	-	-	-	-	ko00000,ko01000,ko01002,ko03029	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_1531542_1	58123.JOFJ01000020_gene3763	9.3e-18	87.4	COG0615@1|root,COG0615@2|Bacteria,2IC88@201174|Actinobacteria,4EH6N@85012|Streptosporangiales	201174|Actinobacteria	IM	Sulfotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
k59_1033598_1	926569.ANT_29620	4.01e-88	270.0	COG1180@1|root,COG1180@2|Bacteria,2G6B2@200795|Chloroflexi	200795|Chloroflexi	C	PFAM Radical SAM domain protein	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
k59_1420606_1	296591.Bpro_4334	4.69e-89	273.0	COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,2VI0E@28216|Betaproteobacteria,4ABVU@80864|Comamonadaceae	28216|Betaproteobacteria	L	Integrase, catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	HTH_38,rve
k59_1143745_1	69279.BG36_04905	7e-48	164.0	COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,2TS7B@28211|Alphaproteobacteria,43JQ6@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	L	Transposase domain (DUF772)	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
k59_922631_1	1336243.JAEA01000003_gene2240	2.85e-90	275.0	COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,2TSDZ@28211|Alphaproteobacteria,1JQVR@119045|Methylobacteriaceae	28211|Alphaproteobacteria	H	Belongs to the FPP GGPP synthase family	ispB	GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009108,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0042180,GO:0042181,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110	-	R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
k59_1420615_1	1217652.F954_01279	1.09e-07	53.1	COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,1RM89@1236|Gammaproteobacteria,3NIU8@468|Moraxellaceae	1236|Gammaproteobacteria	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
k59_1420615_2	545695.TREAZ_0138	4.05e-41	148.0	COG0324@1|root,COG0324@2|Bacteria,2J6T2@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	-	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
k59_922633_1	69014.TK1775	1.86e-92	283.0	COG3839@1|root,arCOG00175@2157|Archaea,2Y7MN@28890|Euryarchaeota,2431V@183968|Thermococci	183968|Thermococci	G	Function Code 14.4 Transport and Binding Proteins Carbohydrates, organic alcohols, and acids	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE_2
k59_977213_1	32057.KB217478_gene6093	5.31e-35	134.0	COG4826@1|root,COG4826@2|Bacteria,1G29E@1117|Cyanobacteria,1HIIV@1161|Nostocales	1117|Cyanobacteria	O	Belongs to the serpin family	-	-	-	ko:K13963	ko05146,map05146	-	-	-	ko00000,ko00001	-	-	-	Serpin
k59_1255782_1	1430440.MGMSRv2_0542	2.52e-72	228.0	COG2022@1|root,COG2022@2|Bacteria,1N0N5@1224|Proteobacteria,2TSXS@28211|Alphaproteobacteria,2JPMG@204441|Rhodospirillales	204441|Rhodospirillales	H	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S	thiG	-	2.8.1.10	ko:K03149	ko00730,ko01100,map00730,map01100	-	R10247	RC03096,RC03097,RC03461	ko00000,ko00001,ko01000	-	-	-	ThiG,ThiS
k59_809378_1	102129.Lepto7375DRAFT_0663	9.94e-38	141.0	COG3547@1|root,COG3547@2|Bacteria,1G077@1117|Cyanobacteria,1H97S@1150|Oscillatoriales	1117|Cyanobacteria	L	Transposase IS116/IS110/IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_698999_1	748727.CLJU_c18900	6.09e-86	277.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247T8@186801|Clostridia,36EMB@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_1476935_2	290397.Adeh_0412	8.52e-08	56.2	COG1921@1|root,COG1921@2|Bacteria,1MWXI@1224|Proteobacteria,42MU7@68525|delta/epsilon subdivisions,2WJFQ@28221|Deltaproteobacteria,2YU5T@29|Myxococcales	28221|Deltaproteobacteria	H	Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis	selA	GO:0003674,GO:0003824,GO:0004125,GO:0006139,GO:0006399,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016785,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034654,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097056,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901576	2.9.1.1	ko:K01042	ko00450,ko00970,map00450,map00970	-	R08219	RC01246	ko00000,ko00001,ko01000	-	-	-	Se-cys_synth_N,SelA
k59_309543_1	1128421.JAGA01000004_gene2611	9.96e-46	163.0	COG0031@1|root,COG0031@2|Bacteria,2NP1M@2323|unclassified Bacteria	2|Bacteria	E	Pyridoxal-phosphate dependent enzyme	cysK	-	2.5.1.47,4.2.1.22	ko:K01697,ko:K01738	ko00260,ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021,M00035,M00338	R00891,R00897,R01290,R03601,R04859,R04942	RC00020,RC00056,RC00069,RC00256,RC00489,RC01246,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	CBS,PALP
k59_809380_1	987059.RBXJA2T_02175	1.6e-15	70.9	COG0198@1|root,COG0198@2|Bacteria,1MZQD@1224|Proteobacteria,2VUC6@28216|Betaproteobacteria,1KM1K@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit	rplX	-	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
k59_809380_2	257313.BP3626	8.87e-71	214.0	COG0093@1|root,COG0093@2|Bacteria,1RCWZ@1224|Proteobacteria,2VR2N@28216|Betaproteobacteria,3T3WR@506|Alcaligenaceae	28216|Betaproteobacteria	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	-	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
k59_1699963_1	640081.Dsui_0177	3.45e-05	46.2	28JXH@1|root,2ZA3Z@2|Bacteria,1R8CZ@1224|Proteobacteria,2VMM6@28216|Betaproteobacteria,2KZ12@206389|Rhodocyclales	206389|Rhodocyclales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1365552_1	485918.Cpin_3450	3.77e-09	60.8	COG1629@1|root,COG4771@2|Bacteria,4NGAK@976|Bacteroidetes,1IQJ6@117747|Sphingobacteriia	976|Bacteroidetes	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
k59_420090_1	224324.aq_2104	4.82e-07	52.4	COG0365@1|root,COG0365@2|Bacteria,2G4GP@200783|Aquificae	200783|Aquificae	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA_1	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_420090_2	1402135.SUH3_23340	2.33e-53	182.0	COG3396@1|root,COG3396@2|Bacteria,1MXUK@1224|Proteobacteria,2TTIG@28211|Alphaproteobacteria,3ZVPS@60136|Sulfitobacter	28211|Alphaproteobacteria	S	benzoyl-CoA oxygenase	boxB	-	1.14.13.208	ko:K15512	ko00362,map00362	-	R09555	RC01739	ko00000,ko00001,ko01000	-	-	-	-
k59_1753232_1	861299.J421_6082	3.62e-54	180.0	COG3375@1|root,COG3375@2|Bacteria,1ZUBU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	carboxylic acid catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1198427_1	269799.Gmet_1417	5.49e-10	55.8	COG0776@1|root,COG0776@2|Bacteria,1RH5Z@1224|Proteobacteria,42TK0@68525|delta/epsilon subdivisions,2WQ5D@28221|Deltaproteobacteria,43VBY@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control	himA	-	-	ko:K04764	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
k59_1198427_2	1336245.JAGO01000012_gene1860	1.03e-17	85.5	COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,1RMIH@1236|Gammaproteobacteria,1XHN9@135619|Oceanospirillales	135619|Oceanospirillales	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
k59_477659_1	1510531.JQJJ01000009_gene615	3.05e-93	301.0	COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,2TSVH@28211|Alphaproteobacteria,3JRWJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Putative amidoligase enzyme (DUF2126)	MA20_16195	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,DUF2126,Transglut_core
k59_641373_1	644524.C5IHQ5_9CAUD	1.72e-58	198.0	4QHMY@10239|Viruses,4QW88@35237|dsDNA viruses  no RNA stage,4QSGS@28883|Caudovirales,4QNFN@10744|Podoviridae	10744|Podoviridae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_863546_1	379066.GAU_3855	3.78e-58	190.0	COG0767@1|root,COG0767@2|Bacteria,1ZUC4@142182|Gemmatimonadetes	142182|Gemmatimonadetes	Q	Permease MlaE	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
k59_699031_1	493475.GARC_2623	1.47e-68	222.0	COG0738@1|root,COG0738@2|Bacteria,1MXDC@1224|Proteobacteria,1RQX9@1236|Gammaproteobacteria,4659F@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	Major Facilitator Superfamily	fucP	-	-	ko:K02429	-	-	-	-	ko00000,ko02000	2.A.1.7	-	-	MFS_1
k59_977267_1	926561.KB900617_gene1653	2.31e-44	161.0	COG1492@1|root,COG1492@2|Bacteria,1TP5E@1239|Firmicutes,248XW@186801|Clostridia,3WBI4@53433|Halanaerobiales	186801|Clostridia	H	Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation	cobQ	-	6.3.5.10	ko:K02232	ko00860,ko01100,map00860,map01100	M00122	R05225	RC00010,RC01302	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS15780	AAA_26,CbiA,GATase_3
k59_477666_1	1449044.JMLE01000004_gene2482	4.99e-54	184.0	COG4941@1|root,COG4941@2|Bacteria,2GJ36@201174|Actinobacteria,1WB8F@1268|Micrococcaceae	201174|Actinobacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_1033680_1	221288.JH992900_gene319	1.33e-65	201.0	COG4288@1|root,COG4288@2|Bacteria,1G65D@1117|Cyanobacteria,1JKYE@1189|Stigonemataceae	1117|Cyanobacteria	S	Anabaena sensory rhodopsin transducer	-	-	-	-	-	-	-	-	-	-	-	-	ASRT
k59_586277_1	1120705.FG95_03243	5.12e-16	75.5	COG1801@1|root,COG1801@2|Bacteria,1MU7F@1224|Proteobacteria,2TT1D@28211|Alphaproteobacteria,2K8RV@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
k59_586277_2	266117.Rxyl_0345	4.19e-34	127.0	COG0501@1|root,COG0501@2|Bacteria,2GMJF@201174|Actinobacteria,4CQF1@84995|Rubrobacteria	84995|Rubrobacteria	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
k59_364082_1	926569.ANT_23480	3.24e-67	227.0	COG0209@1|root,COG0209@2|Bacteria,2G5PW@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdA	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Intein_splicing,Ribonuc_red_lgC,Ribonuc_red_lgN,TSCPD
k59_141423_2	485914.Hmuk_2931	2.26e-07	53.5	arCOG06234@1|root,arCOG06234@2157|Archaea,2Y05Z@28890|Euryarchaeota,23XJN@183963|Halobacteria	183963|Halobacteria	CP	Helix-hairpin-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HHH_5
k59_44884_1	319003.Bra1253DRAFT_01647	1.4e-28	105.0	COG3360@1|root,COG3360@2|Bacteria,1PE74@1224|Proteobacteria,2UCH8@28211|Alphaproteobacteria,3K04J@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
k59_44884_2	1463825.JNXC01000008_gene1256	6.45e-15	77.0	COG0045@1|root,COG1042@1|root,COG1247@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1247@2|Bacteria,2GKN1@201174|Actinobacteria,4DZ1D@85010|Pseudonocardiales	201174|Actinobacteria	C	CoA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
k59_992533_1	1120934.KB894407_gene5183	0.000328	44.3	COG0823@1|root,COG0823@2|Bacteria,2GMNT@201174|Actinobacteria,4DY93@85010|Pseudonocardiales	201174|Actinobacteria	U	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,PD40
k59_1768089_1	1089550.ATTH01000001_gene812	2.06e-27	115.0	COG1361@1|root,COG4412@1|root,COG4932@1|root,COG1361@2|Bacteria,COG4412@2|Bacteria,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	-	ko:K07004,ko:K09955,ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Laminin_G_3
k59_938572_1	1380394.JADL01000008_gene3462	1.42e-32	127.0	COG1360@1|root,COG1360@2|Bacteria,1MW1Y@1224|Proteobacteria,2TTW2@28211|Alphaproteobacteria,2JPI3@204441|Rhodospirillales	204441|Rhodospirillales	N	Membrane MotB of proton-channel complex MotA/MotB	motB	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotB_plug,OmpA
k59_1271800_1	1123073.KB899242_gene1451	2.73e-71	232.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,1RPIW@1236|Gammaproteobacteria,1X5RA@135614|Xanthomonadales	135614|Xanthomonadales	Q	Amidohydrolase family	-	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
k59_992555_1	589865.DaAHT2_1603	4.23e-19	91.7	COG0845@1|root,COG0845@2|Bacteria,1PEVY@1224|Proteobacteria,42NTH@68525|delta/epsilon subdivisions,2WJ8N@28221|Deltaproteobacteria,2MIMX@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
k59_434823_1	1150626.PHAMO_250002	2.17e-27	105.0	COG3293@1|root,COG3293@2|Bacteria,1MYPD@1224|Proteobacteria,2UBMY@28211|Alphaproteobacteria,2JUP2@204441|Rhodospirillales	204441|Rhodospirillales	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_2
k59_1492592_1	1121438.JNJA01000008_gene3896	1.19e-18	82.4	COG1014@1|root,COG1014@2|Bacteria,1R8XG@1224|Proteobacteria,42NPD@68525|delta/epsilon subdivisions,2X6SX@28221|Deltaproteobacteria,2MAAP@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM Pyruvate ketoisovalerate oxidoreductase	korC	-	1.2.7.3	ko:K00177	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
k59_1492592_2	1183377.Py04_1550	1.54e-32	123.0	COG1013@1|root,arCOG01599@2157|Archaea,2XUSE@28890|Euryarchaeota,242ZV@183968|Thermococci	183968|Thermococci	C	ferredoxin oxidoreductase	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
k59_1326431_2	670292.JH26_15620	8.48e-09	62.0	COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2TRC2@28211|Alphaproteobacteria,1JSC4@119045|Methylobacteriaceae	28211|Alphaproteobacteria	I	Carbamoyl-phosphate synthetase large chain domain protein	pccA	GO:0003674,GO:0003824,GO:0004658,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009374,GO:0009987,GO:0016421,GO:0016874,GO:0016885,GO:0017144,GO:0019752,GO:0019842,GO:0019899,GO:0031406,GO:0031974,GO:0032787,GO:0033218,GO:0033293,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0070013,GO:0071704,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901681	6.4.1.3	ko:K01965	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
k59_938591_2	493475.GARC_1242	1.77e-16	80.9	COG1266@1|root,COG1266@2|Bacteria	2|Bacteria	V	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
k59_600667_1	1121918.ARWE01000001_gene1768	1.38e-78	257.0	COG1410@1|root,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,42NHZ@68525|delta/epsilon subdivisions,2WJ2H@28221|Deltaproteobacteria,43U7R@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Methionine synthase B12-binding module cap domain protein	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_44929_1	420324.KI912044_gene3920	3.99e-68	218.0	COG3391@1|root,COG3391@2|Bacteria,1R9D3@1224|Proteobacteria,2UQK7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_715087_1	56110.Oscil6304_3682	5.4e-45	165.0	COG0438@1|root,COG0457@1|root,COG0859@1|root,COG0438@2|Bacteria,COG0457@2|Bacteria,COG0859@2|Bacteria,1G193@1117|Cyanobacteria,1H799@1150|Oscillatoriales	1117|Cyanobacteria	M	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF4915,Glyco_transf_9,Glycos_transf_1,TPR_1,TPR_11,TPR_16,TPR_17,TPR_2,TPR_8
k59_1656708_1	251221.35212995	3.53e-13	74.7	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_1602925_1	1396141.BATP01000026_gene1035	1.03e-64	208.0	COG0191@1|root,COG0191@2|Bacteria,46UMQ@74201|Verrucomicrobia,2ITR6@203494|Verrucomicrobiae	203494|Verrucomicrobiae	G	Fructose-bisphosphate aldolase class-II	-	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
k59_1326479_1	331869.BAL199_16288	3.88e-94	289.0	COG2252@1|root,COG2252@2|Bacteria,1MUV0@1224|Proteobacteria,2TRC0@28211|Alphaproteobacteria,4BPXU@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Permease family	purP	-	-	ko:K06901	-	-	-	-	ko00000,ko02000	2.A.1.40	-	-	Xan_ur_permease
k59_434885_1	1242864.D187_000296	1.04e-101	312.0	COG1274@1|root,COG1274@2|Bacteria,1MX3C@1224|Proteobacteria,42PRT@68525|delta/epsilon subdivisions,2WIWH@28221|Deltaproteobacteria,2YU1K@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	-	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2638	PEPCK_C,PEPCK_N
k59_1161501_1	1380384.JADN01000004_gene2272	5.51e-21	99.0	COG0612@1|root,COG0612@2|Bacteria,4NEPT@976|Bacteroidetes,1HWQI@117743|Flavobacteriia	976|Bacteroidetes	S	Peptidase M16	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_436356_1	1430440.MGMSRv2_2767	8.2e-44	157.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,2TRFB@28211|Alphaproteobacteria,2JQCK@204441|Rhodospirillales	204441|Rhodospirillales	S	Belongs to the peptidase M16 family	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_381372_1	644548.SCNU_01705	4.48e-10	58.9	COG0640@1|root,COG0640@2|Bacteria,2IMSD@201174|Actinobacteria,4GENG@85026|Gordoniaceae	201174|Actinobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	smtB	GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010035,GO:0010038,GO:0010043,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0042221,GO:0044212,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	ko:K22298	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
k59_1658521_1	313612.L8106_21312	6.97e-16	83.6	COG3899@1|root,COG5001@1|root,COG3899@2|Bacteria,COG5001@2|Bacteria,1GBKM@1117|Cyanobacteria,1H7D9@1150|Oscillatoriales	1117|Cyanobacteria	KLT	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GAF,GAF_2,GGDEF,Guanylate_cyc,HATPase_c,HisKA,PAS_3,PAS_4,Pkinase,Response_reg
k59_436378_2	765912.Thimo_3228	1.31e-25	103.0	COG4221@1|root,COG4221@2|Bacteria,1RF5D@1224|Proteobacteria,1S5AC@1236|Gammaproteobacteria,1WZIP@135613|Chromatiales	135613|Chromatiales	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_46474_1	1227739.Hsw_1064	3.06e-125	371.0	COG0167@1|root,COG1149@1|root,COG0167@2|Bacteria,COG1149@2|Bacteria,4NGSB@976|Bacteroidetes,47U8D@768503|Cytophagia	976|Bacteroidetes	F	Catalyzes the conversion of dihydroorotate to orotate	-	-	1.3.1.1,1.3.98.1	ko:K00226,ko:K17723	ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100	M00046,M00051	R00977,R01414,R01867,R11026	RC00051,RC00072,RC00123	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh,Fer4_21
k59_1161576_1	644282.Deba_2993	1.92e-35	139.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_717059_1	472759.Nhal_2136	7.41e-98	310.0	COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,1RMUH@1236|Gammaproteobacteria,1WWAH@135613|Chromatiales	135613|Chromatiales	C	TIGRFAM NADH-quinone oxidoreductase, chain G	-	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdop_Fe4S4,Molybdopterin,NADH-G_4Fe-4S_3
k59_46480_1	1502852.FG94_04596	2.88e-18	89.0	COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,2VH9R@28216|Betaproteobacteria,473F1@75682|Oxalobacteraceae	28216|Betaproteobacteria	U	Involved in the TonB-independent uptake of proteins	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
k59_1494457_1	861299.J421_3522	4.33e-72	243.0	COG0013@1|root,COG0013@2|Bacteria,1ZT18@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
k59_1328362_1	234267.Acid_5466	1.22e-31	133.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_717067_1	471857.Svir_18740	6.4e-24	102.0	COG1414@1|root,COG1414@2|Bacteria,2IESA@201174|Actinobacteria,4E1EJ@85010|Pseudonocardiales	201174|Actinobacteria	K	helix_turn_helix isocitrate lyase regulation	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
k59_769251_1	1120919.AUBI01000001_gene2929	4.31e-42	152.0	COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,2TRI7@28211|Alphaproteobacteria,2JPWT@204441|Rhodospirillales	204441|Rhodospirillales	S	A circularly permuted ATPgrasp	-	-	-	-	-	-	-	-	-	-	-	-	CP_ATPgrasp_2
k59_495272_1	404589.Anae109_3668	8.25e-68	222.0	COG2197@1|root,COG2197@2|Bacteria,1R03J@1224|Proteobacteria	1224|Proteobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE
k59_1437419_1	485913.Krac_0986	1.39e-66	221.0	COG0492@1|root,COG3437@1|root,COG0492@2|Bacteria,COG3437@2|Bacteria,2G5Z5@200795|Chloroflexi	200795|Chloroflexi	C	FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Response_reg
k59_940199_1	1207063.P24_16897	3.4e-19	84.3	COG5387@1|root,COG5387@2|Bacteria,1Q3B5@1224|Proteobacteria,2TVK1@28211|Alphaproteobacteria,2JSH3@204441|Rhodospirillales	204441|Rhodospirillales	O	COG5387 Chaperone required for the assembly of the mitochondrial F1-ATPase	-	-	-	-	-	-	-	-	-	-	-	-	ATP12
k59_940199_2	1111728.ATYS01000022_gene3847	2.59e-09	62.8	COG2982@1|root,COG2982@2|Bacteria,1MUAN@1224|Proteobacteria,1RNZM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	protein involved in outer membrane biogenesis	yhjG	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0032386,GO:0032879,GO:0032880,GO:0033157,GO:0044464,GO:0050789,GO:0051049,GO:0051223,GO:0060341,GO:0065007,GO:0070201,GO:0071944,GO:0090087,GO:0090313,GO:1903533,GO:1903827,GO:1905475	-	ko:K07290	-	-	-	-	ko00000	9.B.121	-	-	AsmA
k59_46502_1	246196.MSMEI_4105	2.94e-27	115.0	COG1404@1|root,COG1404@2|Bacteria,2GKJR@201174|Actinobacteria,234P1@1762|Mycobacteriaceae	201174|Actinobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
k59_1328389_1	1121904.ARBP01000022_gene3483	2.92e-55	194.0	COG3537@1|root,COG3537@2|Bacteria,4NDYB@976|Bacteroidetes,47KZ5@768503|Cytophagia	976|Bacteroidetes	G	PFAM Glycosyl Hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_92
k59_1716799_1	1255043.TVNIR_2359	8.7e-83	256.0	COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria	1224|Proteobacteria	P	Belongs to the ABC transporter superfamily	dppD	-	-	ko:K02031,ko:K12371	ko02010,ko02024,map02010,map02024	M00239,M00324	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_1273850_1	1123288.SOV_2c00250	1.7e-33	132.0	COG0477@1|root,COG2814@2|Bacteria,1TQHD@1239|Firmicutes,4H2AI@909932|Negativicutes	909932|Negativicutes	EGP	Major Facilitator	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
k59_327407_1	484770.UFO1_3056	0.000271	48.5	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,4H2VB@909932|Negativicutes	909932|Negativicutes	NT	SMART chemotaxis sensory transducer, histidine kinase HAMP region domain protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,dCache_1
k59_1273862_1	56110.Oscil6304_1218	1.09e-33	134.0	COG0642@1|root,COG3452@1|root,COG5002@1|root,COG2205@2|Bacteria,COG3452@2|Bacteria,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	-	ko:K11959,ko:K19694	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko01001,ko02000,ko02022	3.A.1.4.4,3.A.1.4.5	-	-	CHASE,EAL,GAF,GGDEF,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
k59_1273865_1	1267533.KB906738_gene2047	1.45e-20	89.4	COG1430@1|root,COG1430@2|Bacteria,3Y5J5@57723|Acidobacteria,2JJXT@204432|Acidobacteriia	204432|Acidobacteriia	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
k59_381509_1	105559.Nwat_1345	6.5e-10	63.5	COG1301@1|root,COG1301@2|Bacteria,1MU0Q@1224|Proteobacteria,1RMEN@1236|Gammaproteobacteria,1WWIC@135613|Chromatiales	135613|Chromatiales	U	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family	-	-	-	-	-	-	-	-	-	-	-	-	SDF
k59_1494554_1	997884.HMPREF1068_02810	1.19e-38	143.0	COG1858@1|root,COG1858@2|Bacteria,4NE50@976|Bacteroidetes,2FR90@200643|Bacteroidia,4APJC@815|Bacteroidaceae	976|Bacteroidetes	C	cytochrome C peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
k59_381518_1	1254432.SCE1572_35745	1.33e-54	188.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2YTW0@29|Myxococcales	28221|Deltaproteobacteria	T	response regulator	-	-	-	ko:K02481,ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_881546_2	1380394.JADL01000001_gene2058	1.08e-23	101.0	COG0859@1|root,COG0859@2|Bacteria,1PV11@1224|Proteobacteria,2U3V4@28211|Alphaproteobacteria,2JRZZ@204441|Rhodospirillales	204441|Rhodospirillales	M	COG0859 ADP-heptose LPS heptosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9
k59_1437484_1	439235.Dalk_1215	4.92e-98	298.0	COG2368@1|root,COG2368@2|Bacteria,1PEQG@1224|Proteobacteria,42NUH@68525|delta/epsilon subdivisions,2WISE@28221|Deltaproteobacteria,2MI4T@213118|Desulfobacterales	28221|Deltaproteobacteria	Q	PFAM 4-hydroxyphenylacetate 3-hydroxylase N terminal	-	-	4.2.1.120,5.3.3.3	ko:K14534	ko00650,ko00720,ko01100,ko01120,ko01200,map00650,map00720,map01100,map01120,map01200	M00374,M00375	R03031,R10782	RC01857,RC03277	ko00000,ko00001,ko00002,ko01000	-	-	-	HpaB,HpaB_N
k59_1383075_1	926569.ANT_29700	1.61e-06	55.5	COG1178@1|root,COG1178@2|Bacteria,2G5Q0@200795|Chloroflexi	200795|Chloroflexi	P	binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
k59_769315_1	272942.RCAP_rcc00136	5.42e-47	164.0	COG1785@1|root,COG1785@2|Bacteria,1MXI2@1224|Proteobacteria,2TTUZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Belongs to the alkaline phosphatase family	phoA	-	3.1.3.1	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	Alk_phosphatase
k59_1658673_1	861299.J421_4104	2.2e-07	54.7	COG5492@1|root,COG5492@2|Bacteria,1ZUE7@142182|Gemmatimonadetes	142182|Gemmatimonadetes	N	Bacterial Ig-like domain 2	-	-	-	-	-	-	-	-	-	-	-	-	Big_2
k59_495381_1	1121456.ATVA01000014_gene568	3.62e-12	73.6	COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,42M28@68525|delta/epsilon subdivisions,2WJPF@28221|Deltaproteobacteria,2M9FY@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
k59_1383093_1	1411685.U062_00759	4.31e-42	152.0	COG3004@1|root,COG3004@2|Bacteria,1MW15@1224|Proteobacteria,1RNDE@1236|Gammaproteobacteria,1J5GM@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons	nhaA	-	-	ko:K03313	-	-	-	-	ko00000,ko02000	2.A.33.1	-	-	Na_H_antiport_1
k59_1214917_1	1499967.BAYZ01000148_gene1745	1.73e-10	66.2	COG0760@1|root,COG0760@2|Bacteria,2NPFB@2323|unclassified Bacteria	2|Bacteria	O	PPIC-type PPIASE domain	-	-	5.2.1.8	ko:K03769,ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
k59_211946_1	479432.Sros_5933	1.64e-07	51.2	298YA@1|root,2ZW25@2|Bacteria,2GIYI@201174|Actinobacteria,4EIRQ@85012|Streptosporangiales	201174|Actinobacteria	S	Protein of unknown function (DUF3090)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3090
k59_1494609_1	1123508.JH636439_gene519	5.95e-18	87.8	COG1520@1|root,COG1520@2|Bacteria,2IWR8@203682|Planctomycetes	203682|Planctomycetes	S	beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
k59_994185_1	358396.C445_20750	2.02e-24	100.0	COG1194@1|root,arCOG00462@2157|Archaea,2XSU9@28890|Euryarchaeota,23TBS@183963|Halobacteria	183963|Halobacteria	L	COG1194 A G-specific DNA glycosylase	mutY	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
k59_1161762_1	926569.ANT_21930	3.39e-35	137.0	COG5492@1|root,COG5492@2|Bacteria	2|Bacteria	N	domain, Protein	-	-	3.2.1.81,3.2.1.97	ko:K01219,ko:K17624	-	-	-	-	ko00000,ko01000	-	GH101	-	Big_2,CBM_6,Cytochrome_C7,F5_F8_type_C,Glyco_hyd_101C,Glyco_hydro_101,WxL
k59_547862_1	1122933.JNIY01000003_gene92	1.01e-77	248.0	COG0659@1|root,COG0659@2|Bacteria,2GJCB@201174|Actinobacteria,4F24H@85016|Cellulomonadaceae	201174|Actinobacteria	P	Sulfate permease family	-	GO:0000103,GO:0000166,GO:0003333,GO:0003674,GO:0005215,GO:0005310,GO:0005326,GO:0005342,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006790,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0006836,GO:0006855,GO:0006865,GO:0008150,GO:0008152,GO:0008272,GO:0008509,GO:0008514,GO:0009987,GO:0015075,GO:0015103,GO:0015116,GO:0015138,GO:0015141,GO:0015171,GO:0015172,GO:0015179,GO:0015183,GO:0015238,GO:0015318,GO:0015556,GO:0015698,GO:0015711,GO:0015740,GO:0015741,GO:0015744,GO:0015800,GO:0015807,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0017076,GO:0019001,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0036094,GO:0042221,GO:0042493,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0070778,GO:0071422,GO:0071702,GO:0071705,GO:0071944,GO:0072348,GO:0097159,GO:0098656,GO:0098660,GO:0098661,GO:1901265,GO:1901363,GO:1901682,GO:1902358,GO:1902475,GO:1903825,GO:1905039	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
k59_1437543_1	926569.ANT_19610	8.34e-12	65.9	COG0546@1|root,COG0546@2|Bacteria	2|Bacteria	S	glycolate biosynthetic process	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
k59_1214962_1	1161401.ASJA01000002_gene2556	4.12e-53	182.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2TR6Q@28211|Alphaproteobacteria,43WPJ@69657|Hyphomonadaceae	28211|Alphaproteobacteria	L	COG0513 Superfamily II DNA and RNA helicases	rhlE	-	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
k59_1437559_1	1380391.JIAS01000018_gene930	8.91e-99	312.0	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,2TQMY@28211|Alphaproteobacteria,2JQK4@204441|Rhodospirillales	204441|Rhodospirillales	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc
k59_1328594_1	861299.J421_3108	8.14e-53	176.0	2F044@1|root,33T7T@2|Bacteria,1ZTDC@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1437562_1	1089552.KI911559_gene2194	8.98e-72	238.0	COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,1MV6C@1224|Proteobacteria,2TUJB@28211|Alphaproteobacteria,2JQGJ@204441|Rhodospirillales	204441|Rhodospirillales	C	Domain of unknown function (DUF4445)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
k59_46616_2	926549.KI421517_gene3213	4.29e-23	94.0	COG2259@1|root,COG2259@2|Bacteria,4PB3J@976|Bacteroidetes,47V4B@768503|Cytophagia	976|Bacteroidetes	S	DoxX	-	-	-	-	-	-	-	-	-	-	-	-	DoxX
k59_495465_1	414684.RC1_2592	8.1e-82	269.0	COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,2TSV0@28211|Alphaproteobacteria,2JPGY@204441|Rhodospirillales	204441|Rhodospirillales	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	GO:0006355,GO:0006464,GO:0006807,GO:0006808,GO:0007154,GO:0007584,GO:0008150,GO:0008152,GO:0009605,GO:0009719,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0018175,GO:0018177,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070887,GO:0071310,GO:0071417,GO:0071495,GO:0071496,GO:0071704,GO:0080090,GO:0090293,GO:1901564,GO:1901698,GO:1901699,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,GlnD_UR_UTase,HD,NTP_transf_2
k59_1214985_1	1408164.MOLA814_00003	1.34e-33	126.0	COG1622@1|root,COG2863@1|root,COG1622@2|Bacteria,COG2863@2|Bacteria,1MVYW@1224|Proteobacteria,2VIDQ@28216|Betaproteobacteria	28216|Betaproteobacteria	C	cytochrome c oxidase (Subunit II)	coxM	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,Cytochrom_C
k59_1214985_2	105559.Nwat_2788	1.05e-21	90.1	29GYT@1|root,303WG@2|Bacteria,1RET9@1224|Proteobacteria,1S6VD@1236|Gammaproteobacteria,1X0VV@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_211983_1	1120950.KB892764_gene5640	3.35e-77	258.0	COG2902@1|root,COG2902@2|Bacteria,2GK0C@201174|Actinobacteria,4DNQX@85009|Propionibacteriales	201174|Actinobacteria	E	Bacterial NAD-glutamate dehydrogenase	gdh	-	1.4.1.2	ko:K15371	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	-	R00243	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	Bac_GDH
k59_1618382_1	1120999.JONM01000010_gene4105	5.06e-101	315.0	COG0699@1|root,COG0699@2|Bacteria,1MXBK@1224|Proteobacteria,2VKA1@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Dynamin family	-	-	-	-	-	-	-	-	-	-	-	-	Dynamin_N
k59_1285017_1	1392488.JHZY01000002_gene905	7.16e-51	175.0	COG2303@1|root,COG2303@2|Bacteria,4NEF2@976|Bacteroidetes,1HWUY@117743|Flavobacteriia,2XJSU@283735|Leeuwenhoekiella	976|Bacteroidetes	E	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N,NAD_binding_8
k59_673670_1	926569.ANT_04570	1.17e-58	187.0	298YA@1|root,2ZW25@2|Bacteria,2G6UQ@200795|Chloroflexi	200795|Chloroflexi	S	Protein of unknown function (DUF3090)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3090
k59_6558_1	1227457.C451_09580	4.69e-11	67.8	COG0589@1|root,arCOG00449@2157|Archaea,2XU1P@28890|Euryarchaeota,23TI5@183963|Halobacteria	183963|Halobacteria	T	COG0589 Universal stress protein UspA and related nucleotide-binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_1285026_1	1123508.JH636445_gene6869	1.83e-44	156.0	COG3635@1|root,COG3635@2|Bacteria,2IY5S@203682|Planctomycetes	203682|Planctomycetes	G	phosphoglycerate mutase	-	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
k59_61982_1	457570.Nther_1154	7.79e-113	346.0	COG3666@1|root,COG3666@2|Bacteria,1TQQ9@1239|Firmicutes,24AG9@186801|Clostridia	186801|Clostridia	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_951551_1	1268303.RHODMAR_1174	1.36e-34	133.0	COG1249@1|root,COG1249@2|Bacteria,2GIXY@201174|Actinobacteria,4FUB1@85025|Nocardiaceae	201174|Actinobacteria	C	Dihydrolipoyl dehydrogenase	pdhD	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_397167_1	1123053.AUDG01000048_gene1824	2.91e-45	164.0	COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,1RQGQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	COG1680 Beta-lactamase class C and other penicillin binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_8282_1	330214.NIDE0008	3.54e-35	124.0	COG2259@1|root,COG2259@2|Bacteria,3J13I@40117|Nitrospirae	2|Bacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
k59_1064271_1	588581.Cpap_3778	1.56e-12	71.2	COG1652@1|root,COG1652@2|Bacteria,1VPEN@1239|Firmicutes,24AK1@186801|Clostridia	186801|Clostridia	S	Lysin motif	-	-	-	-	-	-	-	-	-	-	-	-	LysM
k59_1342283_1	1469607.KK073769_gene6219	8.5e-106	313.0	COG1117@1|root,COG1117@2|Bacteria,1G0P6@1117|Cyanobacteria,1HIVS@1161|Nostocales	1117|Cyanobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
k59_1731404_1	500633.CLOHIR_01075	6.86e-10	64.3	COG0006@1|root,COG0006@2|Bacteria,1TQ6R@1239|Firmicutes,25CCC@186801|Clostridia,25UMA@186804|Peptostreptococcaceae	186801|Clostridia	E	Metallopeptidase family M24	pepQ	-	3.4.13.9	ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
k59_786475_1	66373.JOFQ01000008_gene420	2.21e-15	80.9	COG0768@1|root,COG0768@2|Bacteria,2GJUQ@201174|Actinobacteria	201174|Actinobacteria	M	penicillin-binding protein	pbpA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K05364	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01011	-	-	-	Transpeptidase
k59_953067_1	671143.DAMO_1428	4.63e-87	268.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,2NNKV@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribBA	GO:0003674,GO:0003824,GO:0003933,GO:0003935,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0008686,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0016829,GO:0016830,GO:0017144,GO:0018130,GO:0019238,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	3.5.4.25,4.1.99.12	ko:K01497,ko:K02858,ko:K14652	ko00740,ko00790,ko01100,ko01110,ko02024,map00740,map00790,map01100,map01110,map02024	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS10830,iSB619.SA_RS08945	DHBP_synthase,GTP_cyclohydro2
k59_953069_2	926569.ANT_24790	3.28e-46	165.0	COG0243@1|root,COG0243@2|Bacteria,2G844@200795|Chloroflexi	200795|Chloroflexi	C	Molydopterin dinucleotide binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Molybdopterin,Molydop_binding
k59_1397934_1	215803.DB30_0881	7.7e-22	99.4	COG1404@1|root,COG4412@1|root,COG1404@2|Bacteria,COG4412@2|Bacteria,1REF1@1224|Proteobacteria,42Q4N@68525|delta/epsilon subdivisions,2WS51@28221|Deltaproteobacteria,2YWNR@29|Myxococcales	28221|Deltaproteobacteria	O	Fibronectin type 3 domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M6,Peptidase_S8
k59_1397937_1	1500894.JQNN01000001_gene1682	3.26e-42	147.0	COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,2VIM9@28216|Betaproteobacteria,472F5@75682|Oxalobacteraceae	28216|Betaproteobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
k59_1397937_2	983917.RGE_24570	3.48e-29	116.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1MWKS@1224|Proteobacteria,2VHR1@28216|Betaproteobacteria,1KJ89@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
k59_1675918_1	272134.KB731325_gene776	1.44e-18	83.2	COG1943@1|root,COG1943@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,zf-IS66
k59_397228_1	109760.SPPG_03823T1	7.15e-37	141.0	COG0008@1|root,KOG1149@2759|Eukaryota,38CS1@33154|Opisthokonta,3NV5D@4751|Fungi	4751|Fungi	J	Belongs to the class-I aminoacyl-tRNA synthetase family	MSE1	GO:0000166,GO:0000959,GO:0003674,GO:0003824,GO:0004812,GO:0004818,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006424,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032543,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070127,GO:0070149,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140053,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	iMM904.YOL033W,iND750.YOL033W	tRNA-synt_1c
k59_1064313_1	1379270.AUXF01000002_gene1577	1.66e-95	300.0	COG0515@1|root,COG5616@1|root,COG0515@2|Bacteria,COG5616@2|Bacteria,1ZUKV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
k59_1342325_1	485913.Krac_9325	1.81e-57	193.0	COG3039@1|root,COG3039@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
k59_1008986_1	1379270.AUXF01000004_gene2871	2.58e-14	81.3	COG5492@1|root,COG5492@2|Bacteria,1ZUE7@142182|Gemmatimonadetes	142182|Gemmatimonadetes	N	Bacterial Ig-like domain 2	-	-	-	-	-	-	-	-	-	-	-	-	Big_2
k59_1564740_1	880072.Desac_2474	7.1e-83	259.0	COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,42M48@68525|delta/epsilon subdivisions,2WISV@28221|Deltaproteobacteria,2MQ63@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	-	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA_2,ClpB_D2-small
k59_341457_1	1121430.JMLG01000015_gene1849	1.4e-59	204.0	COG0399@1|root,COG0399@2|Bacteria,1TPDH@1239|Firmicutes,24862@186801|Clostridia,261AB@186807|Peptococcaceae	186801|Clostridia	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
k59_1175564_1	309807.SRU_2720	9.89e-54	190.0	COG1506@1|root,COG1506@2|Bacteria,4NDVD@976|Bacteroidetes	976|Bacteroidetes	E	Peptidase S9 prolyl oligopeptidase active site domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9
k59_1731464_1	977880.RALTA_B0003	1.18e-30	108.0	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,2VVTG@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Cold shock protein	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
k59_897980_1	797114.C475_07716	1.9e-07	58.5	COG1520@1|root,arCOG02492@2157|Archaea,2Y7Q0@28890|Euryarchaeota,23SYZ@183963|Halobacteria	183963|Halobacteria	M	COG1520 FOG WD40-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_3
k59_1286787_1	1185876.BN8_04103	1.98e-11	71.2	COG0745@1|root,COG3292@1|root,COG5002@1|root,COG0745@2|Bacteria,COG3292@2|Bacteria,COG5002@2|Bacteria,4NJ2Y@976|Bacteroidetes,47N0D@768503|Cytophagia	976|Bacteroidetes	T	Y_Y_Y domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HTH_18,HisKA,HisKA_2,Reg_prop,Response_reg,Y_Y_Y
k59_1342350_2	477641.MODMU_5298	4.1e-30	125.0	COG0664@1|root,COG1651@1|root,COG3004@1|root,COG0664@2|Bacteria,COG1651@2|Bacteria,COG3004@2|Bacteria,2GKIK@201174|Actinobacteria	201174|Actinobacteria	P	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons	nhaA	-	-	-	-	-	-	-	-	-	-	-	Na_H_antiport_1,Thioredoxin_4
k59_675496_1	67257.JODR01000005_gene2193	1.62e-12	72.8	COG1232@1|root,COG1232@2|Bacteria,2IEDS@201174|Actinobacteria	201174|Actinobacteria	H	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
k59_1675963_1	1521187.JPIM01000021_gene145	5.3e-11	68.6	COG2203@1|root,COG4585@1|root,COG2203@2|Bacteria,COG4585@2|Bacteria,2G8GW@200795|Chloroflexi,3776B@32061|Chloroflexia	32061|Chloroflexia	T	histidine kinase, dimerisation and phosphoacceptor region	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA_3
k59_397276_1	1077972.ARGLB_073_00810	1.58e-10	67.8	COG0288@1|root,COG0659@1|root,COG0288@2|Bacteria,COG0659@2|Bacteria,2GJCB@201174|Actinobacteria,1W7FV@1268|Micrococcaceae	201174|Actinobacteria	P	Sulfate permease family	sulP	-	4.2.1.1	ko:K01673,ko:K03321	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000,ko02000	2.A.53.3	-	iNJ661.Rv3273	Pro_CA,Sulfate_transp
k59_1342370_1	748247.AZKH_0078	4.02e-52	175.0	COG2864@1|root,COG2864@2|Bacteria,1MXFQ@1224|Proteobacteria,2VKTA@28216|Betaproteobacteria,2KVUV@206389|Rhodocyclales	206389|Rhodocyclales	C	formate dehydrogenase	fdhC	-	-	ko:K00127	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Ni_hydr_CYTB
k59_898006_1	1303518.CCALI_00648	9.63e-37	135.0	COG2802@1|root,COG2802@2|Bacteria	2|Bacteria	S	histone H2A-K13 ubiquitination	lonD	-	3.4.21.53	ko:K01338,ko:K07157	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	LON_substr_bdg
k59_1509229_1	926550.CLDAP_32760	1.21e-101	311.0	COG0747@1|root,COG0747@2|Bacteria,2G8RA@200795|Chloroflexi	200795|Chloroflexi	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_1009044_2	1569209.BBPH01000021_gene1772	0.000187	46.2	COG1295@1|root,COG1295@2|Bacteria,1MXQA@1224|Proteobacteria,2TSFP@28211|Alphaproteobacteria,2PUYB@265|Paracoccus	28211|Alphaproteobacteria	S	Virulence factor BrkB	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
k59_1342381_1	1521187.JPIM01000001_gene851	2.35e-45	158.0	COG0566@1|root,COG0566@2|Bacteria,2G6MC@200795|Chloroflexi,376U0@32061|Chloroflexia	32061|Chloroflexia	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	-	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase
k59_397289_1	319003.Bra1253DRAFT_01924	3.16e-12	71.2	COG1173@1|root,COG1173@2|Bacteria,1MWMX@1224|Proteobacteria,2TQZR@28211|Alphaproteobacteria,3JRQ7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	MA20_14685	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_508516_1	1245469.S58_15210	4.64e-36	139.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2TT5E@28211|Alphaproteobacteria,3JRMI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Amidohydrolase family	MA20_04810	-	3.5.1.82	ko:K01461	-	-	-	-	ko00000,ko01000	-	-	-	Amidohydro_3
k59_731212_2	1267535.KB906767_gene4998	2.63e-18	86.7	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_1620160_1	314256.OG2516_00614	5.81e-129	380.0	COG2079@1|root,COG2079@2|Bacteria,1R5UM@1224|Proteobacteria,2U1F8@28211|Alphaproteobacteria,2PFMK@252301|Oceanicola	28211|Alphaproteobacteria	S	MmgE/PrpD family	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
k59_563874_1	667121.ET1_13_02060	1.17e-44	156.0	COG1216@1|root,COG1216@2|Bacteria,1N9P5@1224|Proteobacteria,1RPHG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_1120485_2	1121920.AUAU01000007_gene421	1.21e-06	56.2	COG4148@1|root,COG4148@2|Bacteria,3Y98K@57723|Acidobacteria	57723|Acidobacteria	P	TOBE domain	-	-	3.6.3.29	ko:K02017	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran,TOBE
k59_1342417_1	331869.BAL199_25119	2.05e-20	84.0	COG1826@1|root,COG1826@2|Bacteria	2|Bacteria	U	protein secretion	tatA	GO:0003674,GO:0005215	-	ko:K03116,ko:K03425	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
k59_1342417_2	639283.Snov_1883	6.82e-11	61.6	COG1826@1|root,COG1826@2|Bacteria,1N73F@1224|Proteobacteria,2UF4Z@28211|Alphaproteobacteria,3EZYS@335928|Xanthobacteraceae	28211|Alphaproteobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation	tatB	GO:0003674,GO:0005215	-	ko:K03117	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
k59_786623_1	1123508.JH636439_gene1811	3.21e-33	132.0	COG0060@1|root,COG0060@2|Bacteria,2IWX2@203682|Planctomycetes	203682|Planctomycetes	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
k59_1564828_1	521460.Athe_1405	7.63e-51	179.0	COG0126@1|root,COG0149@1|root,COG0126@2|Bacteria,COG0149@2|Bacteria,1TP3H@1239|Firmicutes,248VS@186801|Clostridia,42F8F@68295|Thermoanaerobacterales	186801|Clostridia	F	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3,5.3.1.1	ko:K00927,ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01015,R01512	RC00002,RC00043,RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
k59_1064407_2	1380391.JIAS01000017_gene522	4.35e-68	209.0	COG0745@1|root,COG0745@2|Bacteria,1RDNP@1224|Proteobacteria,2U7BP@28211|Alphaproteobacteria,2JS99@204441|Rhodospirillales	204441|Rhodospirillales	KT	COG0784 FOG CheY-like receiver	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
k59_8435_1	1238182.C882_3452	9.5e-106	320.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2TRA0@28211|Alphaproteobacteria,2JQ2J@204441|Rhodospirillales	204441|Rhodospirillales	I	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)	-	-	6.4.1.4	ko:K01969	ko00280,ko01100,map00280,map01100	M00036	R04138	RC00367,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_1509271_1	1122134.KB893650_gene432	1.46e-24	102.0	COG1309@1|root,COG1309@2|Bacteria,1RGCX@1224|Proteobacteria,1S8SN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	regulatory protein TetR	-	-	-	ko:K16137	-	-	-	-	ko00000,ko03000	-	-	-	TetR_C_13,TetR_N
k59_1398067_2	99598.Cal7507_2057	3.27e-32	122.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_12,Methyltransf_23,Methyltransf_31
k59_453207_1	335543.Sfum_0154	6.02e-61	206.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,42N1K@68525|delta/epsilon subdivisions,2WIT6@28221|Deltaproteobacteria,2MQAG@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
k59_953208_1	649349.Lbys_0235	6.37e-31	124.0	COG2010@1|root,COG2010@2|Bacteria,4NHQV@976|Bacteroidetes,47N6X@768503|Cytophagia	976|Bacteroidetes	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
k59_1509278_2	926569.ANT_19370	1.11e-16	82.4	COG5653@1|root,COG5653@2|Bacteria,2G6Z0@200795|Chloroflexi	200795|Chloroflexi	M	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_6
k59_841891_1	380358.XALC_0826	2.28e-60	194.0	COG1023@1|root,COG1023@2|Bacteria,1QU14@1224|Proteobacteria,1T1KM@1236|Gammaproteobacteria,1X4EG@135614|Xanthomonadales	135614|Xanthomonadales	G	6-phosphogluconate dehydrogenase	gnd	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
k59_841891_2	1122179.KB890419_gene39	0.000112	45.8	COG0364@1|root,COG0364@2|Bacteria,4NE59@976|Bacteroidetes,1IQZ7@117747|Sphingobacteriia	976|Bacteroidetes	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
k59_174947_1	861299.J421_2748	1.5e-173	512.0	COG0178@1|root,COG0178@2|Bacteria,1ZTDJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_1064433_1	1254432.SCE1572_00985	6.34e-15	79.3	COG3899@1|root,COG3899@2|Bacteria	2|Bacteria	T	PFAM Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
k59_953232_1	1122137.AQXF01000006_gene705	1.39e-55	183.0	COG3959@1|root,COG3959@2|Bacteria,1MWRX@1224|Proteobacteria,2TRA2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Transketolase	tktB	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
k59_1676064_1	1038858.AXBA01000071_gene2908	2.54e-101	301.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2U0FG@28211|Alphaproteobacteria,3F29B@335928|Xanthobacteraceae	28211|Alphaproteobacteria	L	DDE domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
k59_1620213_1	926569.ANT_23380	1.82e-55	185.0	COG0707@1|root,COG0707@2|Bacteria,2G6EH@200795|Chloroflexi	200795|Chloroflexi	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
k59_300086_1	1244869.H261_17086	5.47e-73	234.0	COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,2TS41@28211|Alphaproteobacteria,2JPA9@204441|Rhodospirillales	204441|Rhodospirillales	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	rpoN	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
k59_689745_1	1211115.ALIQ01000190_gene911	5.04e-71	227.0	COG2072@1|root,COG2072@2|Bacteria,1MWPJ@1224|Proteobacteria,2TSQA@28211|Alphaproteobacteria,3NBR2@45404|Beijerinckiaceae	28211|Alphaproteobacteria	P	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	ko:K07222	-	-	-	-	ko00000	-	-	-	Pyr_redox_3
k59_1134572_1	1504319.GM45_1975	4.94e-25	108.0	COG0392@1|root,COG0392@2|Bacteria,2GMAV@201174|Actinobacteria,3UX1X@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	-	-	-	-	-	-	-	-	-	LPG_synthase_TM
k59_1356597_1	1297863.APJF01000004_gene383	3.74e-74	231.0	COG1028@1|root,COG1028@2|Bacteria,1MU3W@1224|Proteobacteria,2TT5X@28211|Alphaproteobacteria,3JU5R@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	KR domain	MA20_31015	-	1.1.1.304,1.1.1.76	ko:K18009	ko00650,map00650	-	R03707,R09078,R10505	RC00205,RC00525	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
k59_1633342_1	1274374.CBLK010000005_gene4557	1.6e-27	112.0	COG1470@1|root,COG1470@2|Bacteria,1TZ9A@1239|Firmicutes,4HD5P@91061|Bacilli,26U3K@186822|Paenibacillaceae	91061|Bacilli	S	NPCBM-associated, NEW3 domain of alpha-galactosidase	-	-	-	-	-	-	-	-	-	-	-	-	NPCBM_assoc
k59_1633342_2	479434.Sthe_2328	5.09e-19	84.3	COG1131@1|root,COG1131@2|Bacteria,2G6HA@200795|Chloroflexi,27Z66@189775|Thermomicrobia	189775|Thermomicrobia	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_411280_1	1089552.KI911559_gene1149	7.59e-17	85.5	COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,2TRWK@28211|Alphaproteobacteria,2JQVC@204441|Rhodospirillales	204441|Rhodospirillales	P	Acts as a magnesium transporter	-	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
k59_1302846_2	1380355.JNIJ01000001_gene3987	1.04e-57	190.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,2TSJQ@28211|Alphaproteobacteria,3JW7Q@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_357054_1	861299.J421_1879	5.75e-60	199.0	COG1252@1|root,COG1252@2|Bacteria,1ZT8C@142182|Gemmatimonadetes	2|Bacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_914862_2	622637.KE124774_gene2503	2.8e-06	52.8	COG0454@1|root,COG0456@2|Bacteria,1N6RY@1224|Proteobacteria,2TSVU@28211|Alphaproteobacteria,36YH9@31993|Methylocystaceae	28211|Alphaproteobacteria	K	FR47-like protein	MA20_25245	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_469871_1	926566.Terro_1601	4.47e-34	127.0	COG3375@1|root,COG3375@2|Bacteria,3Y41E@57723|Acidobacteria,2JI86@204432|Acidobacteriia	204432|Acidobacteriia	S	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_856666_1	757424.Hsero_2826	1.81e-13	65.9	COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,2VSHX@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Belongs to the thioredoxin family	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin
k59_856666_2	1227453.C444_12762	5.58e-34	125.0	COG3358@1|root,arCOG04570@2157|Archaea,2XWQ3@28890|Euryarchaeota,23V6T@183963|Halobacteria	183963|Halobacteria	S	Protein of unknown function (DUF1684)	-	-	-	ko:K09164	-	-	-	-	ko00000	-	-	-	DUF1684
k59_914871_1	861299.J421_4402	5.5e-43	155.0	COG1459@1|root,COG1459@2|Bacteria,1ZT63@142182|Gemmatimonadetes	2|Bacteria	U	Type II secretion system (T2SS), protein F	xpsF	GO:0002790,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0016020,GO:0032940,GO:0033036,GO:0042886,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098776	-	ko:K02455,ko:K02653	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSF
k59_746863_1	1432055.GLUCORHAEAF1_17790	3.52e-08	52.8	COG1853@1|root,COG1853@2|Bacteria,1Q6RV@1224|Proteobacteria,2US3U@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Flavin reductase like domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
k59_746863_2	760192.Halhy_3116	1.57e-23	96.7	COG0457@1|root,COG0457@2|Bacteria,4NQR8@976|Bacteroidetes,1IY1N@117747|Sphingobacteriia	976|Bacteroidetes	S	Protein of unknown function (DUF2911)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2911
k59_1635044_1	935836.JAEL01000003_gene462	7.43e-42	154.0	COG3333@1|root,COG3333@2|Bacteria,1TPE7@1239|Firmicutes,4HADN@91061|Bacilli,1ZBVK@1386|Bacillus	91061|Bacilli	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
k59_1358460_1	1120959.ATXF01000006_gene1920	1.01e-19	92.4	COG2197@1|root,COG2197@2|Bacteria,2GKXJ@201174|Actinobacteria,4FR58@85023|Microbacteriaceae	201174|Actinobacteria	KT	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE
k59_634490_2	1324957.K933_11116	3.51e-34	127.0	COG2116@1|root,arCOG03454@2157|Archaea,2XTKF@28890|Euryarchaeota,23TA8@183963|Halobacteria	183963|Halobacteria	P	COG2116 Formate nitrite family of transporters	-	-	-	ko:K21990	-	-	-	-	ko00000	1.A.16.4	-	-	Form_Nir_trans
k59_691616_1	400682.PAC_15710330	5.44e-100	301.0	COG0372@1|root,KOG2617@2759|Eukaryota,38E3U@33154|Opisthokonta,3BNEP@33208|Metazoa	33208|Metazoa	C	Citrate synthase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Citrate_synt
k59_413187_1	652103.Rpdx1_2999	4.48e-22	93.2	COG3247@1|root,COG3247@2|Bacteria,1R63F@1224|Proteobacteria,2U3AR@28211|Alphaproteobacteria,3JSMV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Short repeat of unknown function (DUF308)	MA20_30435	-	-	-	-	-	-	-	-	-	-	-	DUF308
k59_1469758_1	1211815.CBYP010000007_gene342	1.51e-82	253.0	COG1175@1|root,COG1175@2|Bacteria,2GM6N@201174|Actinobacteria,4ESZB@85013|Frankiales	201174|Actinobacteria	G	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
k59_79362_1	1122135.KB893135_gene1079	6.96e-92	282.0	COG0439@1|root,COG0439@2|Bacteria,1R5XW@1224|Proteobacteria,2TU28@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Biotin carboxylase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1469762_1	313596.RB2501_14289	1.04e-72	242.0	COG1674@1|root,COG1674@2|Bacteria,4NE86@976|Bacteroidetes,1HXBM@117743|Flavobacteriia	976|Bacteroidetes	D	cell division protein FtsK	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
k59_1358473_1	867903.ThesuDRAFT_01707	6.25e-49	169.0	COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,247IP@186801|Clostridia,3WCVR@538999|Clostridiales incertae sedis	186801|Clostridia	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_691628_1	314285.KT71_02627	6.49e-17	85.1	COG5616@1|root,COG5616@2|Bacteria,1NSKC@1224|Proteobacteria,1S0KQ@1236|Gammaproteobacteria,1J82F@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1025761_2	234267.Acid_1594	2.35e-39	134.0	COG1725@1|root,COG1725@2|Bacteria,3Y5VN@57723|Acidobacteria	57723|Acidobacteria	K	helix_turn_helix gluconate operon transcriptional repressor	-	-	-	ko:K07979	-	-	-	-	ko00000,ko03000	-	-	-	GntR
k59_746893_1	926569.ANT_00500	3.03e-62	205.0	COG2211@1|root,COG2211@2|Bacteria,2G6B9@200795|Chloroflexi	200795|Chloroflexi	G	PFAM PUCC protein	-	-	-	ko:K08226	-	-	-	-	ko00000,ko02000	2.A.1.41	-	-	PUCC
k59_1136475_1	1562701.BBOF01000060_gene1736	5.31e-58	191.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2VQF1@28216|Betaproteobacteria,1K4GQ@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Integrase core domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve
k59_579275_1	864051.BurJ1DRAFT_0791	7.25e-05	47.8	COG2864@1|root,COG2864@2|Bacteria,1NJEJ@1224|Proteobacteria,2VKG8@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_634520_1	196367.JNFG01000007_gene6675	2.6e-61	202.0	COG2072@1|root,COG2072@2|Bacteria,1MWPJ@1224|Proteobacteria,2WEKZ@28216|Betaproteobacteria,1KHRW@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Flavin-binding monooxygenase-like	-	-	-	ko:K07222	-	-	-	-	ko00000	-	-	-	Pyr_redox_3
k59_1248889_1	926569.ANT_19490	7.33e-26	100.0	COG2332@1|root,COG2332@2|Bacteria,2G7CS@200795|Chloroflexi	200795|Chloroflexi	O	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH	-	-	-	ko:K02197	-	-	-	-	ko00000	-	-	-	CcmE
k59_1248889_2	926569.ANT_19480	1.69e-23	100.0	COG1138@1|root,COG1138@2|Bacteria,2G5SZ@200795|Chloroflexi	200795|Chloroflexi	O	PFAM Cytochrome C assembly protein	ccmF	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
k59_914939_1	189753.AXAS01000034_gene2706	4.12e-75	250.0	COG0318@1|root,COG0318@2|Bacteria,1MUMC@1224|Proteobacteria,2TR96@28211|Alphaproteobacteria,3JR8T@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	6.2.1.48	ko:K02182	-	-	-	-	ko00000,ko01000	-	-	-	AMP-binding,AMP-binding_C
k59_1080177_1	765420.OSCT_0044	1.17e-72	232.0	COG0842@1|root,COG0842@2|Bacteria,2G6PG@200795|Chloroflexi,37723@32061|Chloroflexia	32061|Chloroflexia	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
k59_246100_1	479434.Sthe_1202	4.91e-96	289.0	COG1250@1|root,COG1250@2|Bacteria,2G6EB@200795|Chloroflexi	200795|Chloroflexi	C	3-hydroxyacyl-CoA dehydrogenase domain protein	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
k59_134649_1	1502852.FG94_04022	0.000243	50.4	COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,2VJSZ@28216|Betaproteobacteria,473JA@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	Histidine kinase	pilL	-	-	ko:K02487,ko:K06596	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg
k59_1025816_1	1205753.A989_03836	8.52e-17	85.1	COG0662@1|root,COG0836@1|root,COG0662@2|Bacteria,COG0836@2|Bacteria,1MV39@1224|Proteobacteria,1RNQI@1236|Gammaproteobacteria,1X3S9@135614|Xanthomonadales	135614|Xanthomonadales	GM	Belongs to the mannose-6-phosphate isomerase type 2 family	cpsB	GO:0003674,GO:0003824,GO:0016740,GO:0016757	2.7.7.13,5.3.1.8	ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00362	R00885,R01819	RC00002,RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
k59_469975_1	926569.ANT_23190	3.27e-51	177.0	COG0457@1|root,COG0457@2|Bacteria,2G8PU@200795|Chloroflexi	200795|Chloroflexi	S	Peptidase_C39 like family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C39_2
k59_524479_1	649831.L083_1842	6.42e-32	117.0	COG0454@1|root,COG0456@2|Bacteria,2INVM@201174|Actinobacteria,4DF64@85008|Micromonosporales	201174|Actinobacteria	K	FR47-like protein	-	-	2.3.1.57	ko:K00657	ko00330,ko01100,ko04216,map00330,map01100,map04216	M00135	R01154	RC00004,RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1
k59_634579_1	1123237.Salmuc_05264	7.12e-63	203.0	COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,2U0EE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
k59_746968_1	443598.AUFA01000023_gene3390	3.33e-62	198.0	COG1028@1|root,COG1028@2|Bacteria,1R3ZC@1224|Proteobacteria,2TUI5@28211|Alphaproteobacteria,3JXQZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_856791_1	1288826.MSNKSG1_08958	8e-95	288.0	COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,1RN91@1236|Gammaproteobacteria,46522@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008760,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016740,GO:0016765,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
k59_856791_2	1323663.AROI01000003_gene2306	0.000289	42.4	COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,1RNAX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity	hisG	-	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG
k59_24250_1	1379270.AUXF01000002_gene1585	1.1e-24	107.0	COG0515@1|root,COG0515@2|Bacteria,1ZUMJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
k59_357204_1	1123320.KB889721_gene7462	2.01e-08	57.8	COG3653@1|root,COG3653@2|Bacteria,2GKMK@201174|Actinobacteria	201174|Actinobacteria	Q	N-acyl-D-aspartate D-glutamate deacylase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_1746838_1	700598.Niako_0740	5.11e-37	139.0	COG0823@1|root,COG0823@2|Bacteria,4NJJ5@976|Bacteroidetes,1IR8J@117747|Sphingobacteriia	976|Bacteroidetes	U	Oligogalacturonate lyase	-	-	4.2.2.6	ko:K01730	ko00040,map00040	-	R04382	RC02124,RC02427	ko00000,ko00001,ko01000	-	-	-	Pectate_lyase22
k59_1303016_1	1179773.BN6_73650	5.24e-19	82.0	COG0254@1|root,COG0254@2|Bacteria,2IQ4I@201174|Actinobacteria,4E5FG@85010|Pseudonocardiales	201174|Actinobacteria	J	Binds the 23S rRNA	rpmE	GO:0008150,GO:0040007	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
k59_1303016_2	314282.PCNPT3_02250	9.42e-25	95.5	COG0211@1|root,COG0211@2|Bacteria,1MZGH@1224|Proteobacteria,1S8R2@1236|Gammaproteobacteria,2QIC7@267894|Psychromonadaceae	1236|Gammaproteobacteria	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	GO:0000027,GO:0001558,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040008,GO:0042254,GO:0042255,GO:0042256,GO:0042273,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048518,GO:0050789,GO:0050794,GO:0051128,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090069,GO:0090070,GO:1901564,GO:1901566,GO:1901576,GO:1902626,GO:1990904	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
k59_969800_1	1088721.NSU_0478	3.64e-55	184.0	COG0391@1|root,COG0391@2|Bacteria,1NK78@1224|Proteobacteria,2TUUA@28211|Alphaproteobacteria,2K3GV@204457|Sphingomonadales	204457|Sphingomonadales	S	LPPG Fo 2-phospho-L-lactate transferase	-	-	2.7.8.28	ko:K11212	ko00680,ko01120,map00680,map01120	M00378	R09398	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	UPF0052
k59_634620_1	926569.ANT_17990	6.97e-67	209.0	COG2345@1|root,COG2345@2|Bacteria,2G79S@200795|Chloroflexi	200795|Chloroflexi	K	PFAM regulatory protein, ArsR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
k59_302233_1	264462.Bd0709	3.61e-52	186.0	COG0577@1|root,COG1136@1|root,COG0577@2|Bacteria,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,4308T@68525|delta/epsilon subdivisions,2MTI3@213481|Bdellovibrionales,2X727@28221|Deltaproteobacteria	213481|Bdellovibrionales	V	membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides	macB	-	-	ko:K02003,ko:K05685	ko02010,map02010	M00258,M00709	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.122.1,3.A.1.122.12	-	-	ABC_tran,FtsX,MacB_PCD
k59_1525111_1	1027273.GZ77_07850	2.57e-105	315.0	COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,1RNDC@1236|Gammaproteobacteria,1XIQR@135619|Oceanospirillales	135619|Oceanospirillales	J	Belongs to the class-I aminoacyl-tRNA synthetase family	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
k59_1025911_1	1463857.JOFZ01000006_gene3444	7.58e-06	54.7	COG0477@1|root,COG2203@1|root,COG2208@1|root,COG4932@1|root,COG0477@2|Bacteria,COG2203@2|Bacteria,COG2208@2|Bacteria,COG4932@2|Bacteria,2GKEF@201174|Actinobacteria	201174|Actinobacteria	T	protein phosphatase 2C domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c_2,SpoIIE
k59_1692474_1	591157.SSLG_04997	4.88e-13	68.2	COG0858@1|root,COG0858@2|Bacteria,2IKXP@201174|Actinobacteria	201174|Actinobacteria	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
k59_190568_1	929703.KE386491_gene3409	7.47e-58	194.0	COG0439@1|root,COG0439@2|Bacteria,4NFEQ@976|Bacteroidetes,47MHE@768503|Cytophagia	976|Bacteroidetes	I	TIGRFAM acetyl-CoA carboxylase, biotin carboxylase	accC	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
k59_134758_1	1121403.AUCV01000054_gene2598	2.02e-66	208.0	COG2220@1|root,COG2220@2|Bacteria,1PFZZ@1224|Proteobacteria,42SXY@68525|delta/epsilon subdivisions,2WPFM@28221|Deltaproteobacteria,2MMG4@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
k59_1413972_1	671143.DAMO_2494	5.08e-78	252.0	COG1132@1|root,COG1132@2|Bacteria,2NNVD@2323|unclassified Bacteria	2|Bacteria	V	ABC transporter	MdlB	-	-	ko:K06147,ko:K18890	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_24312_1	5147.XP_003344217.1	7.37e-13	75.1	COG0318@1|root,KOG1176@2759|Eukaryota,39AHE@33154|Opisthokonta,3P0E3@4751|Fungi,3QSX4@4890|Ascomycota,214E9@147550|Sordariomycetes,3UEMX@5139|Sordariales,3UH7A@5148|Sordariaceae	4751|Fungi	I	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,Hexapep,Hexapep_2,PP-binding
k59_24315_1	415426.Hbut_0783	1.2e-14	74.3	COG1156@1|root,arCOG00865@2157|Archaea,2XPKW@28889|Crenarchaeota	28889|Crenarchaeota	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_24315_2	1235835.C814_02284	1.19e-17	84.7	COG1155@1|root,COG1155@2|Bacteria,1TPGS@1239|Firmicutes,24882@186801|Clostridia,3WGBK@541000|Ruminococcaceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	ntpA	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
k59_1635231_1	767817.Desgi_3802	2.53e-42	155.0	COG1001@1|root,COG1001@2|Bacteria,1TP84@1239|Firmicutes,247KN@186801|Clostridia,260J2@186807|Peptococcaceae	186801|Clostridia	F	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family	-	-	3.5.4.2	ko:K01486	ko00230,ko01100,map00230,map01100	-	R01244	RC00477	ko00000,ko00001,ko01000	-	-	-	Adenine_deam_C,Amidohydro_1
k59_1692504_1	345341.KUTG_04494	2.21e-41	146.0	COG0745@1|root,COG0745@2|Bacteria,2GIZB@201174|Actinobacteria,4DXHB@85010|Pseudonocardiales	201174|Actinobacteria	T	response regulator	mprA	GO:0000160,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006355,GO:0007154,GO:0007165,GO:0008150,GO:0009268,GO:0009628,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010446,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0023052,GO:0030312,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0035556,GO:0043254,GO:0044087,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0090034,GO:0097159,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141	-	ko:K07669,ko:K07672	ko02020,map02020	M00460,M00463	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_1136680_1	1121033.AUCF01000001_gene2294	5.28e-61	194.0	COG0047@1|root,COG0047@2|Bacteria,1MU4Y@1224|Proteobacteria,2TS67@28211|Alphaproteobacteria,2JPBQ@204441|Rhodospirillales	204441|Rhodospirillales	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
k59_1136680_2	290397.Adeh_3840	3.24e-08	52.0	COG1828@1|root,COG1828@2|Bacteria,1N83G@1224|Proteobacteria,42V3S@68525|delta/epsilon subdivisions,2WYEM@28221|Deltaproteobacteria,2Z2JC@29|Myxococcales	28221|Deltaproteobacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purS	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	PurS
k59_413384_1	358681.BBR47_37740	2.69e-06	49.3	COG0540@1|root,COG0540@2|Bacteria,1TQ96@1239|Firmicutes,4H9M6@91061|Bacilli,26S1E@186822|Paenibacillaceae	91061|Bacilli	F	Belongs to the ATCase OTCase family	pyrB	GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU15490	OTCace,OTCace_N
k59_413384_2	1449336.JQLO01000001_gene940	1.79e-18	87.0	COG0044@1|root,COG0044@2|Bacteria,1TPQM@1239|Firmicutes,4HA90@91061|Bacilli,27FE3@186828|Carnobacteriaceae	91061|Bacilli	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	GO:0003674,GO:0003824,GO:0004038,GO:0004151,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046390,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
k59_413385_1	575615.HMPREF0670_00813	7.18e-06	54.7	COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,4NEXU@976|Bacteroidetes,2FM9K@200643|Bacteroidia	976|Bacteroidetes	DM	Chain length determinant protein	ptk_3	-	-	-	-	-	-	-	-	-	-	-	AAA_31,CbiA,GNVR,Wzz
k59_1358667_1	633149.Bresu_3217	5.69e-38	140.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TSB1@28211|Alphaproteobacteria,2KFRT@204458|Caulobacterales	204458|Caulobacterales	EH	Belongs to the TPP enzyme family	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_1358667_2	314278.NB231_09438	3.58e-44	145.0	COG3785@1|root,COG3785@2|Bacteria,1RHM7@1224|Proteobacteria,1T11M@1236|Gammaproteobacteria,1X1AJ@135613|Chromatiales	135613|Chromatiales	S	Hemimethylated DNA-binding protein YccV like	-	-	-	ko:K11940	-	-	-	-	ko00000,ko03036	-	-	-	YccV-like
k59_1320121_2	797303.Natpe_1901	3.43e-23	100.0	COG0183@1|root,arCOG01278@2157|Archaea,2XT38@28890|Euryarchaeota,23TGZ@183963|Halobacteria	183963|Halobacteria	I	COG0183 Acetyl-CoA acetyltransferase	-	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_1486162_1	379066.GAU_1124	1.12e-34	129.0	COG0484@1|root,COG0484@2|Bacteria,1ZT5T@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	-	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
k59_486663_1	765420.OSCT_1835	3.88e-37	143.0	COG0823@1|root,COG1075@1|root,COG0823@2|Bacteria,COG1075@2|Bacteria,2G8T5@200795|Chloroflexi,376FH@32061|Chloroflexia	32061|Chloroflexia	U	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40
k59_486671_1	861299.J421_6188	7.46e-29	121.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_540100_1	316067.Geob_0383	3.98e-46	161.0	COG0182@1|root,COG0182@2|Bacteria,1MUPM@1224|Proteobacteria,42MJ2@68525|delta/epsilon subdivisions,2WJQB@28221|Deltaproteobacteria,43UJ9@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_0072	IF-2B
k59_1709561_1	1379270.AUXF01000005_gene811	4.24e-73	243.0	COG0210@1|root,COG0210@2|Bacteria,1ZTD5@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	UvrD-like helicase C-terminal domain	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_205160_1	697281.Mahau_1185	1.47e-45	162.0	COG1653@1|root,COG1653@2|Bacteria,1TQFZ@1239|Firmicutes,249WU@186801|Clostridia,42ENP@68295|Thermoanaerobacterales	186801|Clostridia	G	PFAM extracellular solute-binding protein family 1	-	-	-	ko:K02027,ko:K10236	ko02010,map02010	M00204,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.17	-	-	SBP_bac_1,SBP_bac_8
k59_986676_1	1071073.KI530537_gene2605	5.03e-34	125.0	COG2320@1|root,COG2320@2|Bacteria,1V3IB@1239|Firmicutes,4HH5X@91061|Bacilli,1ZHJE@1386|Bacillus	91061|Bacilli	K	GrpB protein	yqkA	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10,GrpB
k59_873171_1	633147.Olsu_1758	1.27e-05	52.4	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria,4CUKV@84998|Coriobacteriia	84998|Coriobacteriia	KLT	Kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
k59_1709579_1	357808.RoseRS_1007	1.41e-54	188.0	COG0318@1|root,COG0318@2|Bacteria,2G5Q8@200795|Chloroflexi,376IG@32061|Chloroflexia	32061|Chloroflexia	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.1.3.1,6.2.1.3	ko:K01897,ko:K22319	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
k59_818144_1	1043493.BBLU01000027_gene1871	1.71e-31	118.0	COG1595@1|root,COG1595@2|Bacteria,2GN5Y@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family, ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
k59_540120_1	1033744.CAEL01000019_gene130	1.68e-51	170.0	COG0290@1|root,COG0290@2|Bacteria,1V1RC@1239|Firmicutes,24FUS@186801|Clostridia,22H35@1570339|Peptoniphilaceae	186801|Clostridia	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	-	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
k59_986692_1	1523503.JPMY01000002_gene4010	3.24e-17	86.3	COG0471@1|root,COG0490@1|root,COG0471@2|Bacteria,COG0490@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	COG0471 Di- and tricarboxylate transporters	yfbS	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	CitMHS,Na_sulph_symp,TrkA_C
k59_428857_1	1405.DJ92_5035	1.18e-11	61.2	2DNMG@1|root,32Y46@2|Bacteria,1VK1T@1239|Firmicutes,4HNYW@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_428857_2	709032.Sulku_2214	8.21e-16	77.8	COG1846@1|root,COG1846@2|Bacteria,1ND45@1224|Proteobacteria,42UP2@68525|delta/epsilon subdivisions,2YQ0G@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	K	Transcriptional regulator	-	-	-	ko:K15973	-	-	-	-	ko00000,ko03000	-	-	-	MarR
k59_1486201_2	866775.HMPREF9243_0343	1.37e-31	121.0	COG0682@1|root,COG0682@2|Bacteria,1TPAK@1239|Firmicutes,4HAT0@91061|Bacilli,27DDB@186827|Aerococcaceae	91061|Bacilli	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
k59_1429743_1	671143.DAMO_2378	5.56e-44	145.0	COG2151@1|root,COG2151@2|Bacteria,2NPUI@2323|unclassified Bacteria	2|Bacteria	S	Pfam:DUF59	paaD	-	-	ko:K02612	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001	-	-	-	FeS_assembly_P
k59_1429743_2	880073.Calab_3193	7.75e-14	67.8	COG0822@1|root,COG0822@2|Bacteria,2NPXN@2323|unclassified Bacteria	2|Bacteria	C	NifU-like N terminal domain	nifU	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0010467,GO:0016740,GO:0016782,GO:0019538,GO:0019725,GO:0030003,GO:0036455,GO:0042592,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0046916,GO:0048037,GO:0048878,GO:0050801,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071704,GO:0097428,GO:0098771,GO:1901564	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
k59_932400_1	1121440.AUMA01000020_gene1968	1.37e-78	242.0	COG3271@1|root,COG3271@2|Bacteria,1RAD5@1224|Proteobacteria,42QWA@68525|delta/epsilon subdivisions,2WMVM@28221|Deltaproteobacteria,2M8RA@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C39,Peptidase_C39_2
k59_762318_1	1151119.KB895491_gene1759	6.02e-22	90.9	COG0845@1|root,COG0845@2|Bacteria,2I53W@201174|Actinobacteria	201174|Actinobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_762318_2	365044.Pnap_2183	1.93e-25	105.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2VHCZ@28216|Betaproteobacteria,4A9J4@80864|Comamonadaceae	28216|Betaproteobacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_986704_1	429009.Adeg_1784	5.63e-49	163.0	COG1894@1|root,COG1908@1|root,COG1894@2|Bacteria,COG1908@2|Bacteria,1V7I6@1239|Firmicutes,24JV2@186801|Clostridia,42GG4@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM methyl-viologen-reducing hydrogenase delta subunit	-	-	1.8.98.5,1.8.98.6	ko:K14127	ko00680,map00680	-	R00019,R11943,R11944	RC00011	ko00000,ko00001,ko01000	-	-	-	FlpD,NADH_4Fe-4S
k59_1761615_1	1463885.KL578440_gene3012	1.65e-89	273.0	COG0454@1|root,COG0456@2|Bacteria,2I39R@201174|Actinobacteria	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
k59_649588_1	1379698.RBG1_1C00001G1051	1.1e-08	54.3	COG0377@1|root,COG0377@2|Bacteria,2NP84@2323|unclassified Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
k59_649588_2	358681.BBR47_54430	1.24e-29	118.0	COG0852@1|root,COG0852@2|Bacteria,1UFNI@1239|Firmicutes,4HDV1@91061|Bacilli,26RPJ@186822|Paenibacillaceae	91061|Bacilli	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
k59_1486226_1	292459.STH174	4.23e-31	115.0	COG3877@1|root,COG3877@2|Bacteria,1VAFG@1239|Firmicutes,24MSP@186801|Clostridia	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	DUF2089
k59_986720_2	1172190.M947_10995	3.72e-08	53.5	2DNS2@1|root,32YVY@2|Bacteria,1N9QQ@1224|Proteobacteria,42X5E@68525|delta/epsilon subdivisions,2YSGR@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1761636_1	1265505.ATUG01000001_gene4494	3.96e-12	69.7	COG0665@1|root,COG0665@2|Bacteria	2|Bacteria	E	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	DAO
k59_1374976_1	383372.Rcas_3609	4.5e-29	120.0	COG0842@1|root,COG1131@1|root,COG1716@1|root,COG0842@2|Bacteria,COG1131@2|Bacteria,COG1716@2|Bacteria,2G7J8@200795|Chloroflexi,374RZ@32061|Chloroflexia	32061|Chloroflexia	V	ABC transporter related	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane,ABC_tran,FHA
k59_1265557_1	861299.J421_1017	0.000163	45.4	COG0577@1|root,COG0577@2|Bacteria	861299.J421_1017|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1265557_2	379066.GAU_3824	2.59e-46	171.0	COG1529@1|root,COG1529@2|Bacteria,1ZUS3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C2
k59_1429786_1	33035.JPJF01000051_gene769	2.39e-35	135.0	COG5598@1|root,COG5598@2|Bacteria,1UY21@1239|Firmicutes,248BQ@186801|Clostridia	186801|Clostridia	H	PFAM Trimethylamine methyltransferase (MTTB)	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
k59_1597275_1	1121468.AUBR01000012_gene2600	1.18e-58	197.0	COG1804@1|root,COG1804@2|Bacteria,1TP54@1239|Firmicutes,24AFB@186801|Clostridia	186801|Clostridia	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_1374997_1	313606.M23134_03071	3.62e-51	183.0	COG1629@1|root,COG1629@2|Bacteria,4PM06@976|Bacteroidetes,47Y21@768503|Cytophagia	976|Bacteroidetes	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
k59_708442_1	926560.KE387023_gene3356	8.21e-20	84.7	COG5485@1|root,COG5485@2|Bacteria	2|Bacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL
k59_1320218_1	760568.Desku_0579	2.96e-11	66.6	COG0741@1|root,COG0741@2|Bacteria,1V6K4@1239|Firmicutes,24JB5@186801|Clostridia,2620J@186807|Peptococcaceae	186801|Clostridia	M	transglycosylase	slt	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT
k59_1375006_1	32057.KB217480_gene8203	1.67e-67	217.0	COG0732@1|root,COG0732@2|Bacteria,1G1K5@1117|Cyanobacteria	1117|Cyanobacteria	V	type I restriction modification DNA specificity domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_1761682_1	1382356.JQMP01000004_gene68	1.97e-74	239.0	COG0305@1|root,COG0305@2|Bacteria,2G64D@200795|Chloroflexi,27XKA@189775|Thermomicrobia	189775|Thermomicrobia	L	Participates in initiation and elongation during chromosome replication	-	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
k59_708469_1	10228.TriadP29177	9.6e-89	293.0	COG0458@1|root,KOG0370@2759|Eukaryota,38CAC@33154|Opisthokonta,3B9FF@33208|Metazoa	33208|Metazoa	F	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	CAD	GO:0000050,GO:0000052,GO:0000166,GO:0001882,GO:0001884,GO:0002134,GO:0003674,GO:0003824,GO:0004070,GO:0004087,GO:0004088,GO:0004151,GO:0004672,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006082,GO:0006139,GO:0006206,GO:0006207,GO:0006213,GO:0006220,GO:0006221,GO:0006228,GO:0006464,GO:0006468,GO:0006520,GO:0006525,GO:0006526,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009605,GO:0009719,GO:0009725,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0016053,GO:0016301,GO:0016310,GO:0016363,GO:0016597,GO:0016740,GO:0016741,GO:0016743,GO:0016772,GO:0016773,GO:0016787,GO:0016810,GO:0016812,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0017144,GO:0018107,GO:0018130,GO:0018193,GO:0018210,GO:0019103,GO:0019240,GO:0019438,GO:0019538,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0019899,GO:0030424,GO:0030554,GO:0031406,GO:0031667,GO:0031974,GO:0031981,GO:0032549,GO:0032551,GO:0032553,GO:0032555,GO:0032557,GO:0032559,GO:0032868,GO:0032991,GO:0033267,GO:0034399,GO:0034404,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0036211,GO:0036477,GO:0042221,GO:0042455,GO:0042594,GO:0042802,GO:0042995,GO:0043005,GO:0043025,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043195,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043434,GO:0043436,GO:0043603,GO:0043604,GO:0043679,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0044297,GO:0044306,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044456,GO:0044463,GO:0044464,GO:0045202,GO:0046051,GO:0046112,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046394,GO:0046483,GO:0046777,GO:0046872,GO:0046914,GO:0050896,GO:0055086,GO:0070013,GO:0070335,GO:0070406,GO:0071704,GO:0071941,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:0097458,GO:0098793,GO:0120025,GO:0120038,GO:0140096,GO:0150034,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901652,GO:1901657,GO:1901659,GO:1901698,GO:1901700	2.1.3.2,3.5.2.3,6.3.5.5	ko:K11540	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R01397,R01993,R10948,R10949	RC00002,RC00010,RC00043,RC00064,RC00632,RC02750,RC02798,RC02850,RC03314	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	Amidohydro_1,CPSase_L_D2,CPSase_L_D3,CPSase_sm_chain,GATase,MGS,OTCace,OTCace_N
k59_1597318_1	1121948.AUAC01000002_gene1452	1.7e-169	494.0	COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,2TRCK@28211|Alphaproteobacteria,43WQW@69657|Hyphomonadaceae	28211|Alphaproteobacteria	E	COG0339 Zn-dependent oligopeptidases	dcp	GO:0003674,GO:0003824,GO:0004180,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0016787,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.15.5	ko:K01284	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
k59_818268_1	42256.RradSPS_0726	7.81e-27	113.0	COG3437@1|root,COG3437@2|Bacteria,2I49F@201174|Actinobacteria	201174|Actinobacteria	T	HD-GYP domain	-	-	3.1.26.5	ko:K03540	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	HD_5
k59_39167_1	861299.J421_4428	2.35e-65	213.0	COG0761@1|root,COG0761@2|Bacteria,1ZTGU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	LytB protein	-	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
k59_1096917_1	1121377.KB906412_gene733	9.64e-18	86.7	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Peptidase_S9
k59_1152786_1	1232410.KI421413_gene773	1.56e-23	104.0	COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,42NK9@68525|delta/epsilon subdivisions,2WMCQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,Response_reg
k59_205309_1	671143.DAMO_0707	1.38e-93	290.0	COG1003@1|root,COG1003@2|Bacteria,2NNSG@2323|unclassified Bacteria	2|Bacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	Aminotran_5,GDC-P
k59_39185_2	215803.DB30_4178	2.76e-36	140.0	COG1404@1|root,COG4412@1|root,COG1404@2|Bacteria,COG4412@2|Bacteria,1REF1@1224|Proteobacteria,42Q4N@68525|delta/epsilon subdivisions,2WS51@28221|Deltaproteobacteria,2YWNR@29|Myxococcales	28221|Deltaproteobacteria	O	Fibronectin type 3 domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M6,Peptidase_S8
k59_932536_1	414684.RC1_0138	2.46e-33	124.0	COG0483@1|root,COG0483@2|Bacteria,1NFR1@1224|Proteobacteria,2U1X2@28211|Alphaproteobacteria,2JS26@204441|Rhodospirillales	204441|Rhodospirillales	G	COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
k59_932536_2	1155718.KB891877_gene5322	1.93e-16	79.3	COG0483@1|root,COG0483@2|Bacteria,2GP74@201174|Actinobacteria	201174|Actinobacteria	G	inositol monophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Inositol_P
k59_1265658_2	314260.PB2503_08154	3.15e-29	106.0	COG0776@1|root,COG0776@2|Bacteria,1NM9X@1224|Proteobacteria	1224|Proteobacteria	L	Belongs to the bacterial histone-like protein family	hup	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
k59_986822_1	379066.GAU_2163	9.38e-41	144.0	COG0648@1|root,COG0648@2|Bacteria,1ZSY0@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin	nfo	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
k59_540256_1	1121377.KB906398_gene2691	9.79e-37	142.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria	2|Bacteria	M	serine-type peptidase activity	-	-	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
k59_486825_1	526227.Mesil_1713	5.37e-89	271.0	COG0039@1|root,COG0039@2|Bacteria,1WJHY@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006107,GO:0006108,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009117,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019362,GO:0019637,GO:0019674,GO:0019752,GO:0030060,GO:0034641,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046483,GO:0046496,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0072350,GO:0072524,GO:1901360,GO:1901564	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
k59_1152809_2	880073.Calab_2992	5.52e-25	102.0	COG2818@1|root,COG2818@2|Bacteria,2NP7N@2323|unclassified Bacteria	2|Bacteria	L	Methyladenine glycosylase	tag	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
k59_1486370_1	706587.Desti_3697	3.21e-17	84.7	COG1283@1|root,COG1283@2|Bacteria,1NYQQ@1224|Proteobacteria,430T2@68525|delta/epsilon subdivisions,2WW13@28221|Deltaproteobacteria,2MSGK@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	sodium-dependent phosphate transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_39216_1	1157943.KB892705_gene3487	5.18e-21	87.8	COG2020@1|root,COG2020@2|Bacteria,2IN0C@201174|Actinobacteria,23A25@1762|Mycobacteriaceae	201174|Actinobacteria	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
k59_39216_2	1449347.JQLN01000003_gene5745	6.19e-13	68.2	COG0500@1|root,COG2226@2|Bacteria,2I547@201174|Actinobacteria,2M0WA@2063|Kitasatospora	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_649738_1	1341181.FLJC2902T_15110	6.93e-33	131.0	COG3386@1|root,COG3386@2|Bacteria,4PKPT@976|Bacteroidetes,1IKDI@117743|Flavobacteriia,2P0DY@237|Flavobacterium	976|Bacteroidetes	G	Domain of unknown function (DUF5122) beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	DUF5122
k59_540287_1	1397666.RS24_01385	5.04e-20	94.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,2TRTY@28211|Alphaproteobacteria,4BTGC@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	T	CHASE2	cyaD	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
k59_486856_2	326427.Cagg_0018	4.48e-07	54.3	COG0720@1|root,COG0720@2|Bacteria,2G992@200795|Chloroflexi,3753G@32061|Chloroflexia	32061|Chloroflexia	H	PFAM 6-pyruvoyl tetrahydropterin synthase and	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
k59_986864_1	309807.SRU_1226	1.33e-30	123.0	COG2204@1|root,COG2204@2|Bacteria,4NE89@976|Bacteroidetes,1FIS4@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	T	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1486388_1	525897.Dbac_3169	4.8e-41	143.0	COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,42NJE@68525|delta/epsilon subdivisions,2WKMA@28221|Deltaproteobacteria,2M9N8@213115|Desulfovibrionales	28221|Deltaproteobacteria	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
k59_1207416_1	1313172.YM304_11100	7.16e-28	117.0	COG0308@1|root,COG0308@2|Bacteria,2GJJ4@201174|Actinobacteria,4CMSA@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Peptidase family M1 domain	-	-	-	ko:K08776	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	ERAP1_C,Peptidase_M1
k59_1265723_1	477228.YO5_09365	1.95e-40	152.0	COG3119@1|root,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,1RMJ0@1236|Gammaproteobacteria,1Z3NT@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	P	Sulfatase	-	-	3.1.6.6	ko:K01133	-	-	-	-	ko00000,ko01000	-	-	-	Choline_sulf_C,DUF4976,Sulfatase
k59_1375137_1	1408473.JHXO01000012_gene337	7.06e-10	60.1	COG0473@1|root,COG0473@2|Bacteria,4NGUA@976|Bacteroidetes	976|Bacteroidetes	CE	Isocitrate isopropylmalate dehydrogenase	-	-	1.1.1.41,1.1.1.42,1.1.1.85	ko:K00030,ko:K00031,ko:K00052	ko00020,ko00290,ko00480,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00290,map00480,map00660,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00432,M00535,M00740	R00267,R00268,R00709,R00994,R01899,R04426,R10052	RC00001,RC00084,RC00114,RC00417,RC00626,RC02801,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
k59_1375137_2	1408473.JHXO01000012_gene339	3.87e-08	58.5	COG2301@1|root,COG3052@1|root,COG2301@2|Bacteria,COG3052@2|Bacteria,4NTPZ@976|Bacteroidetes,2FTXP@200643|Bacteroidia	976|Bacteroidetes	G	Belongs to the HpcH HpaI aldolase family	citE	-	-	-	-	-	-	-	-	-	-	-	HpcH_HpaI
k59_540323_2	1379270.AUXF01000006_gene112	8.95e-25	102.0	COG4799@1|root,COG4799@2|Bacteria,1ZTGE@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Carboxyl transferase domain	-	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_152467_1	177439.DP2334	1.64e-22	101.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,42M5I@68525|delta/epsilon subdivisions,2WK8Y@28221|Deltaproteobacteria,2MNI1@213118|Desulfobacterales	28221|Deltaproteobacteria	C	FAD linked oxidases, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_8
k59_501950_1	1382356.JQMP01000004_gene181	1.18e-30	121.0	COG2309@1|root,COG2309@2|Bacteria,2G62B@200795|Chloroflexi,27YZB@189775|Thermomicrobia	189775|Thermomicrobia	E	Thermophilic metalloprotease (M29)	-	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
k59_112760_1	926564.KI911670_gene6264	2.76e-27	120.0	COG0642@1|root,COG2205@2|Bacteria,2GIV9@201174|Actinobacteria,4F3F6@85017|Promicromonosporaceae	201174|Actinobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	phoR	-	2.7.13.3	ko:K02484	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
k59_946744_1	331869.BAL199_19463	3.7e-82	263.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2TSYQ@28211|Alphaproteobacteria,4BPBS@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_1224810_1	1307759.JOMJ01000003_gene1372	0.000111	48.5	COG0730@1|root,COG0730@2|Bacteria,1RFWI@1224|Proteobacteria,42RMT@68525|delta/epsilon subdivisions,2WNYT@28221|Deltaproteobacteria,2MB4Y@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
k59_1391496_1	616991.JPOO01000003_gene2291	1.48e-49	169.0	COG2159@1|root,COG2159@2|Bacteria,4PJ9Q@976|Bacteroidetes,1IEPW@117743|Flavobacteriia,23IFH@178469|Arenibacter	976|Bacteroidetes	S	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_112774_1	985054.JQEZ01000001_gene2890	4.44e-33	122.0	29Q66@1|root,30B54@2|Bacteria,1N9YZ@1224|Proteobacteria,2TS6J@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4166)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4166
k59_112774_2	744980.TRICHSKD4_4727	8.37e-15	73.6	COG1510@1|root,COG1510@2|Bacteria,1RA49@1224|Proteobacteria,2U2X2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Belongs to the GbsR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5,MarR_2
k59_668812_1	1122214.AQWH01000003_gene3924	4.19e-30	119.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQMJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	-	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran,TOBE_2
k59_613152_2	555779.Dthio_PD2789	1.85e-32	114.0	COG1598@1|root,COG1598@2|Bacteria,1NCC0@1224|Proteobacteria,42WMN@68525|delta/epsilon subdivisions,2WRBU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	HicB_like antitoxin of bacterial toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	HicB_lk_antitox
k59_835539_1	1206101.AZXC01000014_gene680	2.46e-28	114.0	COG0021@1|root,COG0021@2|Bacteria,2GJ1K@201174|Actinobacteria	201174|Actinobacteria	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
k59_835539_2	1142394.PSMK_26510	8.89e-15	70.5	COG0698@1|root,COG0698@2|Bacteria,2IZSB@203682|Planctomycetes	203682|Planctomycetes	G	Ribose/Galactose Isomerase	-	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
k59_223984_1	521674.Plim_1917	9.76e-39	141.0	COG4965@1|root,COG4965@2|Bacteria,2IYKD@203682|Planctomycetes	203682|Planctomycetes	U	type II secretion system protein	-	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
k59_1113672_1	234267.Acid_5649	5.19e-30	110.0	COG1848@1|root,COG1848@2|Bacteria,3Y5Q8@57723|Acidobacteria	57723|Acidobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K07064	-	-	-	-	ko00000	-	-	-	PIN
k59_1113672_2	875328.JDM601_1798	1.13e-26	100.0	2DSMH@1|root,33GPM@2|Bacteria,2GR8G@201174|Actinobacteria,23BKG@1762|Mycobacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1502703_1	468059.AUHA01000002_gene563	7.47e-25	108.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,4NFW7@976|Bacteroidetes,1IR3J@117747|Sphingobacteriia	976|Bacteroidetes	K	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	ANAPC3,Guanylate_cyc,HTH_18,TPR_8
k59_1169155_2	861299.J421_1447	2.16e-38	142.0	COG4108@1|root,COG4108@2|Bacteria,1ZSMR@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP	prfC	-	-	ko:K02837	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,RF3_C
k59_1224870_2	331869.BAL199_10030	1.86e-06	50.4	COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,2TRUK@28211|Alphaproteobacteria,4BPSJ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the peptidase M20A family. ArgE subfamily	argE	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
k59_57302_1	1304875.JAFZ01000003_gene644	4.22e-33	123.0	COG0352@1|root,COG0352@2|Bacteria,3TBAB@508458|Synergistetes	508458|Synergistetes	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	thiE	-	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
k59_1447234_1	926569.ANT_30950	2.88e-74	246.0	COG0419@1|root,COG0433@1|root,COG0419@2|Bacteria,COG0433@2|Bacteria,2G87W@200795|Chloroflexi	200795|Chloroflexi	L	AAA-like domain	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_279603_2	591001.Acfer_1710	9.14e-51	174.0	COG0055@1|root,COG0055@2|Bacteria,1TPGF@1239|Firmicutes,4H2IA@909932|Negativicutes	909932|Negativicutes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_613197_1	4792.ETI39820	9.44e-58	202.0	COG0126@1|root,COG0515@1|root,KOG0192@2759|Eukaryota,KOG1367@2759|Eukaryota,3QAK7@4776|Peronosporales	4776|Peronosporales	G	Phosphoglycerate kinase	-	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
k59_1169179_1	1449355.JQNR01000005_gene3108	1.74e-06	50.4	COG0577@1|root,COG1136@1|root,COG0577@2|Bacteria,COG1136@2|Bacteria,2GIRW@201174|Actinobacteria	201174|Actinobacteria	V	ABC-type antimicrobial peptide transport system, permease component	yknZ	-	-	ko:K02004,ko:K05685	ko02010,map02010	M00258,M00709	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.122.1,3.A.1.122.12	-	-	FtsX,MacB_PCD
k59_1169179_2	484770.UFO1_3709	1.82e-38	135.0	COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,4H22T@909932|Negativicutes	909932|Negativicutes	V	Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides	macB	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_946833_1	314265.R2601_10299	5.02e-12	62.8	COG2963@1|root,COG2963@2|Bacteria,1RHKX@1224|Proteobacteria,2U9TV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG2963 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
k59_57319_2	671143.DAMO_3131	1.07e-90	275.0	COG1077@1|root,COG1077@2|Bacteria,2NNVU@2323|unclassified Bacteria	2|Bacteria	D	MreB/Mbl protein	mreB	GO:0000003,GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005856,GO:0005886,GO:0007049,GO:0008150,GO:0008360,GO:0009987,GO:0016020,GO:0019954,GO:0022402,GO:0022414,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0032505,GO:0042802,GO:0043093,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051301,GO:0051302,GO:0051782,GO:0051983,GO:0065007,GO:0065008,GO:0071944	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
k59_557577_1	338963.Pcar_1447	1.14e-58	193.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,42N1C@68525|delta/epsilon subdivisions,2WIP5@28221|Deltaproteobacteria,43S9Y@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	3,4-dihydroxy-2-butanone 4-phosphate synthase	ribBA	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
k59_557577_2	1121430.JMLG01000008_gene1520	2.79e-06	48.9	COG0307@1|root,COG0307@2|Bacteria,1V1EP@1239|Firmicutes,24FVK@186801|Clostridia,260I1@186807|Peptococcaceae	186801|Clostridia	H	TIGRFAM riboflavin synthase, alpha subunit	ribE	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
k59_946834_2	502558.EGYY_12340	2.57e-46	164.0	COG0374@1|root,COG0374@2|Bacteria,2GKQY@201174|Actinobacteria,4CVAH@84998|Coriobacteriia	84998|Coriobacteriia	C	Nickel-dependent hydrogenase	-	-	1.12.99.6	ko:K06281	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
k59_1447259_1	1392838.AWNM01000038_gene962	6.06e-67	216.0	COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,2W1SZ@28216|Betaproteobacteria,3T6IE@506|Alcaligenaceae	28216|Betaproteobacteria	C	oxidoreductases (related to aryl-alcohol dehydrogenases)	yhdN	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_168501_1	251229.Chro_0877	7.51e-38	145.0	COG1132@1|root,COG1132@2|Bacteria,1G1JY@1117|Cyanobacteria,3VINJ@52604|Pleurocapsales	1117|Cyanobacteria	V	ABC-type multidrug transport system ATPase and permease	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_1335983_1	1118054.CAGW01000061_gene2409	4.65e-69	223.0	COG3135@1|root,COG3135@2|Bacteria,1UFIU@1239|Firmicutes,4HE6P@91061|Bacilli,26TTT@186822|Paenibacillaceae	91061|Bacilli	Q	Benzoate membrane transport protein	-	-	-	ko:K05782	-	-	-	-	ko00000,ko02000	2.A.46.1	-	-	BenE
k59_891300_1	1173028.ANKO01000074_gene3007	8.76e-55	194.0	COG2114@1|root,COG2203@1|root,COG2461@1|root,COG5000@1|root,COG2114@2|Bacteria,COG2203@2|Bacteria,COG2461@2|Bacteria,COG5000@2|Bacteria,1FZXP@1117|Cyanobacteria,1H71W@1150|Oscillatoriales	1117|Cyanobacteria	T	Belongs to the adenylyl cyclase class-4 guanylyl cyclase family	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	GAF,Guanylate_cyc,HAMP,PAS,PAS_4,PAS_9,dCache_1
k59_502068_1	690597.JH730929_gene1716	9.07e-49	167.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,1RS1R@1236|Gammaproteobacteria,1YP1X@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	P	ABC transporter permease	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_668898_1	35128.Thaps31021	8.25e-06	53.5	COG0446@1|root,KOG3851@2759|Eukaryota	2759|Eukaryota	Z	sulfide:quinone oxidoreductase activity	sqor	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006518,GO:0006575,GO:0006749,GO:0006750,GO:0006790,GO:0006807,GO:0006873,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009636,GO:0009987,GO:0010035,GO:0010038,GO:0016491,GO:0016667,GO:0016672,GO:0019184,GO:0019222,GO:0019725,GO:0019748,GO:0030002,GO:0030320,GO:0031323,GO:0034641,GO:0036094,GO:0042221,GO:0042398,GO:0042592,GO:0042762,GO:0043043,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044424,GO:0044444,GO:0044464,GO:0044550,GO:0046686,GO:0046937,GO:0046938,GO:0048037,GO:0048878,GO:0050660,GO:0050662,GO:0050789,GO:0050794,GO:0050801,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0055081,GO:0055082,GO:0055083,GO:0055114,GO:0061687,GO:0065007,GO:0065008,GO:0070218,GO:0070219,GO:0070224,GO:0070887,GO:0071241,GO:0071248,GO:0071276,GO:0071585,GO:0071704,GO:0071949,GO:0072501,GO:0072505,GO:0097159,GO:0097237,GO:0097501,GO:0098754,GO:0098771,GO:0098849,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990170,GO:1990748	1.8.5.8	ko:K22470	ko00920,map00920	-	R11929	RC02313	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_1113746_1	861299.J421_0487	1.73e-59	201.0	COG2936@1|root,COG2936@2|Bacteria,1ZUE2@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
k59_613239_1	366394.Smed_1399	1.01e-18	91.3	COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,2TR2H@28211|Alphaproteobacteria,4B7F1@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_279657_1	926569.ANT_03150	2.4e-70	223.0	COG1208@1|root,COG1208@2|Bacteria,2G5KH@200795|Chloroflexi	200795|Chloroflexi	M	PFAM Nucleotidyl transferase	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
k59_1669574_1	439235.Dalk_1409	7.61e-12	73.2	COG0318@1|root,COG0318@2|Bacteria,1MW0Y@1224|Proteobacteria,42UMJ@68525|delta/epsilon subdivisions,2WQY4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	IQ	AMP-binding enzyme	-	-	6.2.1.26	ko:K01911	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R04030	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	AMP-binding,AMP-binding_C,Abhydrolase_6
k59_1224937_1	671143.DAMO_2333	2.94e-85	271.0	COG0556@1|root,COG0556@2|Bacteria,2NNPM@2323|unclassified Bacteria	2|Bacteria	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009314,GO:0009380,GO:0009628,GO:0032991,GO:0042802,GO:0044424,GO:0044464,GO:0050896,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03702,ko:K08999	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
k59_57363_1	1207063.P24_01335	2.24e-101	304.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQQJ@28211|Alphaproteobacteria,2JQRA@204441|Rhodospirillales	204441|Rhodospirillales	E	Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,TOBE_2
k59_168534_1	767817.Desgi_0419	4.1e-34	134.0	COG1529@1|root,COG1529@2|Bacteria,1TP7U@1239|Firmicutes,248BV@186801|Clostridia	186801|Clostridia	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_1280451_1	1379270.AUXF01000006_gene271	8.27e-53	178.0	COG1137@1|root,COG1137@2|Bacteria,1ZT4S@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	ABC transporter	-	-	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran
k59_224081_1	1411123.JQNH01000001_gene906	4.77e-46	163.0	COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,2TW3U@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	ABC-type antimicrobial peptide transport system, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_613245_1	391038.Bphy_7354	3.27e-33	118.0	COG2963@1|root,COG2963@2|Bacteria,1N8Y3@1224|Proteobacteria,2VY0M@28216|Betaproteobacteria,1KAA0@119060|Burkholderiaceae	28216|Betaproteobacteria	L	PFAM transposase IS3 IS911 family protein	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_613245_2	391038.Bphy_7355	7.2e-116	343.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2VQF1@28216|Betaproteobacteria,1K4GQ@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Integrase core domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve
k59_446557_1	435842.HMPREF0848_01063	5.81e-23	98.6	COG0631@1|root,COG0631@2|Bacteria,1V6K5@1239|Firmicutes,4HCDR@91061|Bacilli	91061|Bacilli	T	phosphatase	stp	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
k59_502099_2	319795.Dgeo_1302	1.12e-55	198.0	COG5659@1|root,COG5659@2|Bacteria	2|Bacteria	L	transposition	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
k59_1058020_1	986075.CathTA2_1980	5.26e-39	140.0	COG1489@1|root,COG1489@2|Bacteria,1V1GZ@1239|Firmicutes,4HCPN@91061|Bacilli	91061|Bacilli	S	Belongs to the SfsA family	sfsA	-	-	ko:K06206	-	-	-	-	ko00000	-	-	-	SfsA
k59_1558423_1	109760.SPPG_09271T0	8.27e-12	70.9	COG0318@1|root,COG1020@1|root,COG5245@1|root,KOG2551@1|root,KOG1176@2759|Eukaryota,KOG1178@2759|Eukaryota,KOG2551@2759|Eukaryota,KOG3595@2759|Eukaryota,38ZBR@33154|Opisthokonta,3NXPX@4751|Fungi	4751|Fungi	Q	nonribosomal peptide	-	GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0019184,GO:0019748,GO:0034641,GO:0043043,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044550,GO:0071704,GO:1901564,GO:1901566,GO:1901576	-	ko:K22118	-	-	-	-	ko00000,ko01000	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
k59_946924_1	572477.Alvin_3006	1.13e-39	149.0	COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,1RPJS@1236|Gammaproteobacteria,1WVZW@135613|Chromatiales	135613|Chromatiales	NU	Type II and III secretion system protein	-	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Secretin,Secretin_N
k59_1002523_1	926569.ANT_07080	5.19e-57	188.0	COG0583@1|root,COG0583@2|Bacteria,2G77H@200795|Chloroflexi	200795|Chloroflexi	K	regulatory protein LysR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_335296_1	457425.XNR_2603	2.85e-48	169.0	COG2230@1|root,COG2230@2|Bacteria,2GM5H@201174|Actinobacteria	201174|Actinobacteria	M	synthase	-	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
k59_112950_1	1120998.AUFC01000012_gene464	1.26e-20	90.1	COG0138@1|root,COG0138@2|Bacteria,1TPQ5@1239|Firmicutes,24AB8@186801|Clostridia	186801|Clostridia	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas
k59_112950_2	574376.BAMA_22775	1.77e-25	105.0	COG0150@1|root,COG0150@2|Bacteria,1TP9J@1239|Firmicutes,4HABW@91061|Bacilli,1ZBPS@1386|Bacillus	91061|Bacilli	F	Phosphoribosylformylglycinamidine cyclo-ligase	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
k59_668972_1	5465.ENH79014	3.51e-06	54.3	COG2175@1|root,2QUAD@2759|Eukaryota,38FV9@33154|Opisthokonta,3NYRR@4751|Fungi,3QNJE@4890|Ascomycota,2164S@147550|Sordariomycetes,1F499@1028384|Glomerellales	4751|Fungi	E	Taurine catabolism dioxygenase TauD, TfdA family	-	-	-	ko:K06912	ko00361,ko01120,ko01220,map00361,map01120,map01220	-	R05419,R05493	RC01371,RC01372	ko00000,ko00001,ko01000	-	-	-	TauD
k59_1613950_1	866536.Belba_2575	2.5e-18	87.4	COG1529@1|root,COG1529@2|Bacteria,4NFFU@976|Bacteroidetes	976|Bacteroidetes	C	COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs	-	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C2
k59_1613950_2	234267.Acid_6524	6.29e-12	66.2	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_57425_1	379066.GAU_0025	4.18e-27	106.0	COG0327@1|root,COG0327@2|Bacteria,1ZTE0@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	NIF3 (NGG1p interacting factor 3)	-	-	-	-	-	-	-	-	-	-	-	-	NIF3
k59_57425_2	1161401.ASJA01000025_gene214	4.75e-50	172.0	COG0519@1|root,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,2TRN0@28211|Alphaproteobacteria,43X30@69657|Hyphomonadaceae	28211|Alphaproteobacteria	F	Catalyzes the synthesis of GMP from XMP	guaA	GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
k59_168600_1	290397.Adeh_1535	1.32e-44	155.0	COG1260@1|root,COG1260@2|Bacteria,1N0D9@1224|Proteobacteria,42NWK@68525|delta/epsilon subdivisions,2WM2T@28221|Deltaproteobacteria,2YYFZ@29|Myxococcales	28221|Deltaproteobacteria	I	synthase	-	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth,NAD_binding_5
k59_168600_2	1504822.CCNO01000015_gene509	1.5e-12	67.0	COG0125@1|root,COG0125@2|Bacteria,2NPFT@2323|unclassified Bacteria	2|Bacteria	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004798,GO:0005488,GO:0005515,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009129,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009161,GO:0009165,GO:0009173,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009218,GO:0009219,GO:0009221,GO:0009259,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0018130,GO:0019001,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0019693,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046044,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046872,GO:0046940,GO:0046983,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.1.1.45,2.7.4.9,4.1.1.19	ko:K00560,ko:K00943,ko:K01585	ko00240,ko00330,ko00670,ko01100,ko01523,map00240,map00330,map00670,map01100,map01523	M00053,M00133	R00566,R02094,R02098,R02101	RC00002,RC00219,RC00299,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	iECABU_c1320.ECABU_c13120,iHN637.CLJU_RS00680,iJN746.PP_3363,iLJ478.TM1099,iNJ661.Rv3247c,iSB619.SA_RS02535,ic_1306.c1370	Thymidylate_kin
k59_392224_1	1280949.HAD_09125	1.32e-18	90.9	COG2199@1|root,COG3850@1|root,COG3706@2|Bacteria,COG3850@2|Bacteria,1NECV@1224|Proteobacteria,2TW6S@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	4HB_MCP_1,CHASE3,GGDEF,HAMP
k59_169839_1	472759.Nhal_1221	1.44e-95	286.0	COG5424@1|root,COG5424@2|Bacteria,1NQWN@1224|Proteobacteria,1SMYT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1226401_1	1379270.AUXF01000006_gene175	1.56e-66	212.0	COG1702@1|root,COG1702@2|Bacteria,1ZSSD@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	PhoH-like protein	-	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
k59_614549_1	1048834.TC41_1314	1.15e-48	174.0	COG0550@1|root,COG0550@2|Bacteria,1TPUS@1239|Firmicutes,4HA6C@91061|Bacilli,27819@186823|Alicyclobacillaceae	91061|Bacilli	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
k59_1726434_1	391735.Veis_3044	0.000325	46.2	COG0842@1|root,COG0842@2|Bacteria,1PX28@1224|Proteobacteria,2VYZC@28216|Betaproteobacteria	28216|Betaproteobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC2_membrane_3
k59_1337332_1	1298867.AUES01000085_gene3659	7.38e-40	145.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
k59_3169_1	104355.XP_007863232.1	2.19e-43	156.0	COG0436@1|root,KOG0257@2759|Eukaryota,38EX1@33154|Opisthokonta,3NX3X@4751|Fungi,3UYF5@5204|Basidiomycota,228N1@155619|Agaricomycetes,3H2RD@355688|Agaricomycetes incertae sedis	4751|Fungi	E	Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
k59_3169_2	1123236.KB899383_gene2647	1.49e-34	129.0	COG3507@1|root,COG3507@2|Bacteria,1R3V6@1224|Proteobacteria,1RPI5@1236|Gammaproteobacteria,465M3@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	Glycosyl hydrolases family 43	abnA	-	3.2.1.99	ko:K06113	-	-	-	-	ko00000,ko01000	-	GH43	-	Glyco_hydro_43
k59_1670915_1	378806.STAUR_3085	1.16e-20	95.9	COG1404@1|root,COG4412@1|root,COG1404@2|Bacteria,COG4412@2|Bacteria,1REF1@1224|Proteobacteria,42Q4N@68525|delta/epsilon subdivisions,2WS51@28221|Deltaproteobacteria,2YWNR@29|Myxococcales	28221|Deltaproteobacteria	O	Fibronectin type 3 domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M6,Peptidase_S8
k59_68710_1	118168.MC7420_1256	0.000121	49.3	COG0204@1|root,COG0204@2|Bacteria,1G1SN@1117|Cyanobacteria,1H99E@1150|Oscillatoriales	1117|Cyanobacteria	I	Acyltransferase	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
k59_1680972_1	1121920.AUAU01000017_gene1244	7.89e-19	83.6	COG0233@1|root,COG0233@2|Bacteria,3Y4AP@57723|Acidobacteria	57723|Acidobacteria	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	-	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
k59_1680972_2	1079986.JH164855_gene546	3.31e-23	100.0	COG0020@1|root,COG0020@2|Bacteria,2GK89@201174|Actinobacteria	201174|Actinobacteria	I	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	-	-	-	-	-	-	-	-	-	-	-	-	Prenyltransf,SQS_PSY
k59_1624954_1	1121381.JNIV01000090_gene230	7.39e-52	175.0	COG2059@1|root,COG2059@2|Bacteria,1WKZB@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	Chromate transporter	-	-	-	-	-	-	-	-	-	-	-	-	Chromate_transp
k59_458430_2	945550.VISI1226_08539	2.21e-31	114.0	COG0251@1|root,COG0251@2|Bacteria,1RDJX@1224|Proteobacteria,1THSN@1236|Gammaproteobacteria,1XXEJ@135623|Vibrionales	135623|Vibrionales	J	Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
k59_958263_1	439235.Dalk_5219	3.06e-72	241.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,42NDJ@68525|delta/epsilon subdivisions,2WJSH@28221|Deltaproteobacteria,2MIZ3@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_235865_1	999550.KI421507_gene3163	3.05e-63	201.0	COG2041@1|root,COG2041@2|Bacteria,1MUW0@1224|Proteobacteria,2TS40@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide	msrP	-	-	ko:K07147	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_molyb
k59_235865_2	666681.M301_1375	8.35e-08	54.3	COG2717@1|root,COG2717@2|Bacteria,1RDUP@1224|Proteobacteria,2VRBQ@28216|Betaproteobacteria,2KMMD@206350|Nitrosomonadales	206350|Nitrosomonadales	C	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain	msrQ	-	-	ko:K17247	-	-	-	-	ko00000	-	-	-	Ferric_reduct
k59_1014377_1	481448.Minf_1675	1.89e-55	178.0	COG1225@1|root,COG1225@2|Bacteria,46SWU@74201|Verrucomicrobia,37GJJ@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
k59_568864_1	909943.HIMB100_00001300	4e-57	191.0	COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,2TQKT@28211|Alphaproteobacteria,4BPBW@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
k59_346431_1	1122214.AQWH01000003_gene3945	9.45e-43	152.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQMJ@28211|Alphaproteobacteria,2PKM7@255475|Aurantimonadaceae	28211|Alphaproteobacteria	E	TOBE domain	-	-	-	ko:K02052	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	ABC_tran,TOBE_2
k59_458469_1	1429851.X548_13850	2.93e-22	105.0	COG0642@1|root,COG3292@1|root,COG2205@2|Bacteria,COG3292@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1X4Y5@135614|Xanthomonadales	135614|Xanthomonadales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Reg_prop,Response_reg,Y_Y_Y
k59_402476_1	237368.SCABRO_01831	3.11e-81	258.0	COG1215@1|root,COG1215@2|Bacteria,2IXX6@203682|Planctomycetes	203682|Planctomycetes	M	Glycosyl transferase family group 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glycos_transf_2,PilZ
k59_1681029_1	1122132.AQYH01000008_gene2351	6.32e-52	171.0	COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,2TREC@28211|Alphaproteobacteria,4B7MW@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	Belongs to the D-alanine--D-alanine ligase family	ddl	-	1.3.1.98,6.3.2.4	ko:K00075,ko:K01921	ko00473,ko00520,ko00550,ko01100,ko01502,map00473,map00520,map00550,map01100,map01502	-	R01150,R03191,R03192	RC00064,RC00141,RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
k59_1681029_2	1042326.AZNV01000007_gene3114	1.84e-09	60.1	COG1589@1|root,COG1589@2|Bacteria,1MY1Q@1224|Proteobacteria,2TQPU@28211|Alphaproteobacteria,4B9V8@82115|Rhizobiaceae	28211|Alphaproteobacteria	D	Cell division protein FtsQ	ftsQ	-	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
k59_179796_1	1121468.AUBR01000040_gene1717	3.3e-43	151.0	COG3640@1|root,COG3640@2|Bacteria,1UZHR@1239|Firmicutes,24BYR@186801|Clostridia,42FDR@68295|Thermoanaerobacterales	186801|Clostridia	D	AAA domain	cooC1	-	-	ko:K07321	-	-	-	-	ko00000	-	-	-	CbiA
k59_68774_1	351348.Maqu_0638	0.000627	43.1	COG0451@1|root,COG0451@2|Bacteria,1MWVJ@1224|Proteobacteria,1RNDT@1236|Gammaproteobacteria,4673H@72275|Alteromonadaceae	1236|Gammaproteobacteria	GM	COG0451 Nucleoside-diphosphate-sugar epimerases	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase,NAD_binding_10,RmlD_sub_bind
k59_1459125_1	1123227.KB899343_gene2051	3.74e-49	178.0	COG0166@1|root,COG0176@1|root,COG0166@2|Bacteria,COG0176@2|Bacteria,1MUFP@1224|Proteobacteria,2TQKP@28211|Alphaproteobacteria,2JR0F@204441|Rhodospirillales	204441|Rhodospirillales	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2,5.3.1.9	ko:K01810,ko:K13810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00004,M00007,M00114	R01827,R02739,R02740,R03321	RC00376,RC00439,RC00563,RC00604	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI,TAL_FSA
k59_1014401_1	1122611.KB903986_gene4003	1.14e-32	119.0	COG2080@1|root,COG2080@2|Bacteria,2IJZM@201174|Actinobacteria	201174|Actinobacteria	C	[2Fe-2S] binding domain	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
k59_1014401_2	886293.Sinac_5112	0.000126	43.5	COG0686@1|root,COG0686@2|Bacteria,2IXPP@203682|Planctomycetes	203682|Planctomycetes	C	Belongs to the AlaDH PNT family	-	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
k59_1237674_1	710687.KI912270_gene4789	5.03e-56	194.0	COG0332@1|root,COG0332@2|Bacteria,2IAG3@201174|Actinobacteria	201174|Actinobacteria	I	Pfam 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III	-	-	-	-	-	-	-	-	-	-	-	-	ACP_syn_III,ACP_syn_III_C
k59_346460_1	1163408.UU9_02873	8.6e-50	160.0	COG2967@1|root,COG2967@2|Bacteria,1MZ2Z@1224|Proteobacteria,1S8SE@1236|Gammaproteobacteria,1X6WU@135614|Xanthomonadales	135614|Xanthomonadales	P	protein affecting Mg2 Co2 transport	apaG	-	-	ko:K06195	-	-	-	-	ko00000	-	-	-	DUF525
k59_346460_2	572477.Alvin_0031	5.24e-36	135.0	COG0187@1|root,COG1372@1|root,COG0187@2|Bacteria,COG1372@2|Bacteria,1MVKT@1224|Proteobacteria,1RNB2@1236|Gammaproteobacteria,1WVZ4@135613|Chromatiales	135613|Chromatiales	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_1069534_1	1303518.CCALI_00008	3.48e-09	62.0	COG1266@1|root,COG1266@2|Bacteria	2|Bacteria	V	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
k59_1347418_1	1121468.AUBR01000012_gene2599	6.06e-61	204.0	COG1804@1|root,COG1804@2|Bacteria,1TP54@1239|Firmicutes,24AFB@186801|Clostridia	186801|Clostridia	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_1237682_1	1033802.SSPSH_001313	2.75e-87	282.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,1RQX2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Fad linked oxidase	-	-	-	-	-	-	-	-	-	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17,Fer4_8
k59_1681051_1	314230.DSM3645_17550	7.34e-62	210.0	COG0058@1|root,COG0058@2|Bacteria,2IY0J@203682|Planctomycetes	203682|Planctomycetes	G	COG0058 Glucan phosphorylase	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
k59_791951_1	314266.SKA58_17158	1.51e-27	110.0	COG0483@1|root,COG0483@2|Bacteria,1PPJ0@1224|Proteobacteria,2TQTX@28211|Alphaproteobacteria,2K0WC@204457|Sphingomonadales	204457|Sphingomonadales	G	COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Inositol_P
k59_1125840_1	479434.Sthe_3413	4.88e-76	243.0	COG1032@1|root,COG1032@2|Bacteria,2G6ZI@200795|Chloroflexi	200795|Chloroflexi	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
k59_1347423_1	321327.CYA_1492	1.55e-18	82.4	COG2343@1|root,COG2343@2|Bacteria,1G50P@1117|Cyanobacteria,1H0J9@1129|Synechococcus	1117|Cyanobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_9
k59_179819_1	981383.AEWH01000059_gene2206	1.19e-33	125.0	COG0709@1|root,COG0709@2|Bacteria,1TQCJ@1239|Firmicutes,4HB6P@91061|Bacilli	91061|Bacilli	E	Synthesizes selenophosphate from selenide and ATP	selD	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C
k59_624493_1	351607.Acel_1101	7.98e-104	308.0	COG3384@1|root,COG3384@2|Bacteria,2GT9G@201174|Actinobacteria	201174|Actinobacteria	S	Catalytic LigB subunit of aromatic ring-opening dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	LigB
k59_1237686_1	644282.Deba_1298	1.98e-12	65.1	COG0537@1|root,COG0537@2|Bacteria,1RHYQ@1224|Proteobacteria,42SEG@68525|delta/epsilon subdivisions,2WPFW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	FG	PFAM Histidine triad (HIT) protein	-	-	2.7.7.53	ko:K19710	ko00230,map00230	-	R00126,R01618	RC00002,RC02753,RC02795	ko00000,ko00001,ko01000	-	-	-	CwfJ_C_1,HIT
k59_1237686_2	330214.NIDE0428	1.14e-32	115.0	COG0776@1|root,COG0776@2|Bacteria,3J19J@40117|Nitrospirae	40117|Nitrospirae	L	bacterial (prokaryotic) histone like domain	-	-	-	ko:K05788	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
k59_1069549_1	675635.Psed_5128	2.86e-55	187.0	COG1028@1|root,COG1028@2|Bacteria,2GKI2@201174|Actinobacteria,4DZ52@85010|Pseudonocardiales	201174|Actinobacteria	IQ	short-chain alcohol	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
k59_1459165_2	1536769.P40081_18550	2.5e-61	195.0	COG1670@1|root,COG1670@2|Bacteria,1V63R@1239|Firmicutes,4HIF9@91061|Bacilli,26X04@186822|Paenibacillaceae	91061|Bacilli	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
k59_1681082_1	35760.BCHO_1147	1.12e-27	111.0	COG3707@1|root,COG3707@2|Bacteria,2GK7T@201174|Actinobacteria,4CYS7@85004|Bifidobacteriales	201174|Actinobacteria	T	Response regulator receiver domain protein	pdtaR	GO:0000160,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0016020,GO:0023052,GO:0030312,GO:0035556,GO:0040007,GO:0043167,GO:0043168,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071944	-	ko:K22010	-	M00839	-	-	ko00000,ko00002,ko02022	-	-	-	ANTAR,Response_reg
k59_346504_1	713587.THITH_08610	8.64e-94	294.0	COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,1RN6Z@1236|Gammaproteobacteria,1WW4U@135613|Chromatiales	135613|Chromatiales	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
k59_791992_1	1123250.KB908387_gene592	0.000371	48.5	COG2812@1|root,COG2812@2|Bacteria,1TPS9@1239|Firmicutes,4H359@909932|Negativicutes	909932|Negativicutes	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
k59_513706_2	1123388.AQWU01000032_gene414	4.38e-28	108.0	COG0122@1|root,COG0122@2|Bacteria,1WJT0@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	L	PFAM HhH-GPD superfamily base excision DNA repair protein	-	-	3.2.2.21	ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
k59_1125882_1	178306.PAE3237	0.000455	49.3	COG1680@1|root,arCOG00771@2157|Archaea,2XQ49@28889|Crenarchaeota	28889|Crenarchaeota	E	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,Pab87_oct
k59_179860_1	1121405.dsmv_2694	3.43e-31	129.0	COG1042@1|root,COG1042@2|Bacteria,1NU6B@1224|Proteobacteria,42NAU@68525|delta/epsilon subdivisions,2WJHX@28221|Deltaproteobacteria,2MIMR@213118|Desulfobacterales	28221|Deltaproteobacteria	C	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
k59_1625071_1	333138.LQ50_20165	5.94e-98	297.0	2A6Y1@1|root,30VSZ@2|Bacteria,1UBKQ@1239|Firmicutes,4IN0U@91061|Bacilli,1ZMG5@1386|Bacillus	91061|Bacilli	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_1347477_2	378806.STAUR_2750	2.04e-41	138.0	COG1359@1|root,COG1359@2|Bacteria,1N1AN@1224|Proteobacteria,431D5@68525|delta/epsilon subdivisions,2WWP5@28221|Deltaproteobacteria,2YW2W@29|Myxococcales	28221|Deltaproteobacteria	S	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1237735_1	631454.N177_2563	6.81e-41	137.0	COG0227@1|root,COG0227@2|Bacteria,1MZ57@1224|Proteobacteria,2UBQU@28211|Alphaproteobacteria,1JPA9@119043|Rhodobiaceae	28211|Alphaproteobacteria	J	Ribosomal L28 family	rpmB	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
k59_846804_1	219305.MCAG_04833	7.96e-06	53.5	COG2203@1|root,COG2508@1|root,COG2203@2|Bacteria,COG2508@2|Bacteria,2GM1G@201174|Actinobacteria,4D9KW@85008|Micromonosporales	201174|Actinobacteria	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HTH_30
k59_736483_2	522306.CAP2UW1_1277	1.73e-16	80.9	COG0741@1|root,COG0741@2|Bacteria,1MZ4X@1224|Proteobacteria,2VKFN@28216|Betaproteobacteria	28216|Betaproteobacteria	M	PFAM Lytic transglycosylase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	DUF4124,SLT
k59_1069599_1	546275.FUSPEROL_00447	4.16e-58	194.0	COG1509@1|root,COG1509@2|Bacteria,37952@32066|Fusobacteria	32066|Fusobacteria	C	Lysine-2,3-aminomutase	ablA	-	5.4.3.2	ko:K01843	ko00310,map00310	-	R00461	RC00303	ko00000,ko00001,ko01000	-	-	-	Fer4_12,LAM_C,Radical_SAM
k59_736486_1	398720.MED217_12309	1.27e-42	158.0	COG0823@1|root,COG1262@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1262@2|Bacteria,COG1506@2|Bacteria,4NHS5@976|Bacteroidetes,1HZ0Y@117743|Flavobacteriia,2XKCW@283735|Leeuwenhoekiella	976|Bacteroidetes	EU	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,PD40,Peptidase_S9
k59_1014500_1	1120917.AQXM01000058_gene535	2.18e-52	182.0	COG1175@1|root,COG1175@2|Bacteria,2GJGB@201174|Actinobacteria,1W7MN@1268|Micrococcaceae	201174|Actinobacteria	G	N-terminal of TM subunit in PBP-dependent ABC transporters	malF	-	-	ko:K15771	ko02010,map02010	M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.16,3.A.1.1.2	-	-	BPD_transp_1,TM_PBP2_N
k59_346543_1	1479237.JMLY01000001_gene1414	4.95e-21	97.4	COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,1RN9H@1236|Gammaproteobacteria,464KX@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	Catalyzes cross-linking of the peptidoglycan cell wall	mrdA	GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042493,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0045229,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:0071972,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	iEcE24377_1341.EcE24377A_0661,iPC815.YPO2604	PBP_dimer,Transpeptidase
k59_1570063_1	644282.Deba_1961	2.69e-31	125.0	COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,42M3C@68525|delta/epsilon subdivisions,2WJ21@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	rpoN	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
k59_1237767_1	880073.Calab_1092	5.15e-37	143.0	COG1034@1|root,COG1034@2|Bacteria	2|Bacteria	C	ATP synthesis coupled electron transport	nuoG	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_904845_1	1232410.KI421418_gene2434	6.48e-66	214.0	COG1073@1|root,COG1765@1|root,COG1073@2|Bacteria,COG1765@2|Bacteria,1N2BT@1224|Proteobacteria,42NP7@68525|delta/epsilon subdivisions,2WKJU@28221|Deltaproteobacteria,43TFQ@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	OsmC-like protein	-	-	-	ko:K06889,ko:K07397	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Hydrolase_4,OsmC
k59_237359_1	671143.DAMO_0323	1.15e-43	151.0	COG0142@1|root,COG0142@2|Bacteria,2NP6N@2323|unclassified Bacteria	2|Bacteria	H	Belongs to the FPP GGPP synthase family	ispA	GO:0003674,GO:0003824,GO:0004161,GO:0004311,GO:0004337,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009536,GO:0009842,GO:0009987,GO:0016114,GO:0016740,GO:0016765,GO:0019637,GO:0033383,GO:0033384,GO:0033385,GO:0033386,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0045337,GO:0045338,GO:0071704,GO:0090407,GO:1901576	2.5.1.1,2.5.1.10,2.5.1.29,2.5.1.90	ko:K00795,ko:K02523,ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00366	R01658,R02003,R02061,R09248	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	iPC815.YPO3176,iSFV_1184.SFV_0386	polyprenyl_synt
k59_237359_2	338966.Ppro_1190	1.53e-23	99.4	COG0451@1|root,COG0451@2|Bacteria,1MW32@1224|Proteobacteria,42NJT@68525|delta/epsilon subdivisions,2WM7E@28221|Deltaproteobacteria,43UJ6@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	NmrA-like family	hpnA	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase
k59_793332_1	1120919.AUBI01000002_gene1154	1.09e-05	50.1	COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,2TS8U@28211|Alphaproteobacteria,2JPQ0@204441|Rhodospirillales	204441|Rhodospirillales	I	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxD	-	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,LpxD
k59_1239114_1	258594.RPA0660	4.57e-98	295.0	COG1924@1|root,COG1924@2|Bacteria,1MY0N@1224|Proteobacteria,2U4V9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Benzoyl-CoA reductase subunit	-	-	1.3.7.8	ko:K04115	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R02451	RC00002,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	BcrAD_BadFG
k59_904868_1	929703.KE386491_gene1472	7.47e-76	253.0	COG1506@1|root,COG1506@2|Bacteria,4NDVD@976|Bacteroidetes,47N2Q@768503|Cytophagia	976|Bacteroidetes	E	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9
k59_904868_2	760192.Halhy_4150	1.42e-10	60.5	COG1506@1|root,COG1506@2|Bacteria,4NDVD@976|Bacteroidetes,1IR4H@117747|Sphingobacteriia	976|Bacteroidetes	E	peptidase S9 prolyl oligopeptidase active site domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9
k59_1127293_2	234267.Acid_5783	1.23e-24	102.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
k59_460104_1	1122929.KB908218_gene1573	3.37e-31	124.0	COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,2TQZW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	-	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
k59_625829_1	1267535.KB906767_gene5193	1.37e-30	122.0	COG1322@1|root,COG1322@2|Bacteria,3Y3JC@57723|Acidobacteria,2JHYC@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1348875_2	1121033.AUCF01000001_gene2350	2.87e-05	50.1	COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,2TSJ3@28211|Alphaproteobacteria,2JQQD@204441|Rhodospirillales	204441|Rhodospirillales	O	Chaperone SurA	surA	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,SurA_N,SurA_N_3
k59_347885_1	926569.ANT_01870	2.2e-91	277.0	COG2876@1|root,COG2876@2|Bacteria,2G643@200795|Chloroflexi	200795|Chloroflexi	E	PFAM DAHP synthetase I KDSA	-	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
k59_1239158_1	1247024.JRLH01000016_gene1680	9.72e-15	70.1	2EMPC@1|root,33FBT@2|Bacteria,1QNQV@1224|Proteobacteria,1SI44@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_515230_1	926569.ANT_02250	2.17e-74	240.0	COG0532@1|root,COG0532@2|Bacteria,2G5UR@200795|Chloroflexi	200795|Chloroflexi	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
k59_70233_2	65497.JODV01000004_gene1477	1.31e-07	55.5	COG4319@1|root,COG4319@2|Bacteria,2IMHY@201174|Actinobacteria,4EBHJ@85010|Pseudonocardiales	201174|Actinobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440,SnoaL_2,SnoaL_3
k59_1415941_1	1273103.NM10_03573	6.53e-09	62.0	COG1420@1|root,COG1420@2|Bacteria,1TQP7@1239|Firmicutes,4H260@909932|Negativicutes	909932|Negativicutes	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA,HrcA_DNA-bdg
k59_1305242_1	1215114.BBIU01000002_gene254	3.84e-15	76.6	COG3206@1|root,COG3206@2|Bacteria,1MVBX@1224|Proteobacteria,1RXY8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	protein involved in exopolysaccharide biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	Wzz
k59_1305242_2	1026882.MAMP_00857	8.85e-23	93.2	COG1596@1|root,COG1596@2|Bacteria,1N7GP@1224|Proteobacteria,1RQSM@1236|Gammaproteobacteria,461GY@72273|Thiotrichales	72273|Thiotrichales	M	Polysaccharide biosynthesis/export protein	-	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
k59_972031_1	1144310.PMI07_005553	3.06e-55	187.0	COG2079@1|root,COG2079@2|Bacteria,1NECN@1224|Proteobacteria,2UQ0A@28211|Alphaproteobacteria,4BCZD@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Protein involved in propionate catabolism	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
k59_1694772_1	13689.BV96_01649	3.44e-69	210.0	COG3293@1|root,COG3293@2|Bacteria,1REVC@1224|Proteobacteria,2U6ZB@28211|Alphaproteobacteria,2KCRY@204457|Sphingomonadales	204457|Sphingomonadales	L	Putative transposase of IS4/5 family (DUF4096)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4096
k59_1360718_1	1189612.A33Q_2172	4.55e-50	167.0	COG0315@1|root,COG0521@1|root,COG0315@2|Bacteria,COG0521@2|Bacteria,4NHA0@976|Bacteroidetes,47M7C@768503|Cytophagia	976|Bacteroidetes	H	Molybdenum cofactor biosynthesis protein	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoaC
k59_1360718_2	1450525.JATV01000002_gene2012	4.95e-23	92.4	COG0314@1|root,COG0314@2|Bacteria,4NP1X@976|Bacteroidetes,1I24D@117743|Flavobacteriia,2NV6E@237|Flavobacterium	976|Bacteroidetes	H	Molybdopterin converting factor	moaE	-	2.8.1.12	ko:K03635	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE
k59_26349_2	1111069.TCCBUS3UF1_10290	2.43e-10	68.9	COG0702@1|root,COG0702@2|Bacteria,1WJH3@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	GM	Protein of unknown function (DUF2867)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2867,NAD_binding_10,NmrA
k59_749010_1	479434.Sthe_1115	5.09e-80	256.0	COG2204@1|root,COG2204@2|Bacteria,2G5ZP@200795|Chloroflexi	200795|Chloroflexi	T	Two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1028280_1	1693.BMIN_0269	8.39e-66	218.0	COG0507@1|root,COG0507@2|Bacteria,2HFY1@201174|Actinobacteria,4CZ0C@85004|Bifidobacteriales	201174|Actinobacteria	L	PIF1-like helicase	-	-	-	-	-	-	-	-	-	-	-	-	PIF1
k59_81818_1	1125863.JAFN01000001_gene912	3.5e-23	103.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJN5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_804681_2	395493.BegalDRAFT_1340	3.01e-19	85.1	COG0741@1|root,COG0741@2|Bacteria,1MZ4X@1224|Proteobacteria,1S8R3@1236|Gammaproteobacteria,460FY@72273|Thiotrichales	72273|Thiotrichales	M	PFAM Transglycosylase SLT domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4124,SLT
k59_804686_1	1179773.BN6_84030	9.67e-14	70.5	COG1725@1|root,COG1725@2|Bacteria,2IQK1@201174|Actinobacteria,4E6AB@85010|Pseudonocardiales	201174|Actinobacteria	K	helix_turn_helix gluconate operon transcriptional repressor	-	-	-	-	-	-	-	-	-	-	-	-	GntR
k59_1305294_1	314230.DSM3645_18221	3.19e-09	57.4	COG0215@1|root,COG0215@2|Bacteria,2IX9C@203682|Planctomycetes	203682|Planctomycetes	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
k59_1305294_2	926569.ANT_30570	4.29e-122	359.0	COG4956@1|root,COG4956@2|Bacteria,2G5YK@200795|Chloroflexi	200795|Chloroflexi	S	SMART Nucleotide binding protein, PINc	-	-	-	-	-	-	-	-	-	-	-	-	TRAM
k59_1028313_1	290397.Adeh_0829	4.16e-103	321.0	COG4412@1|root,COG4412@2|Bacteria,1P5IH@1224|Proteobacteria	1224|Proteobacteria	O	Peptidase M6, immune inhibitor A	ina	-	-	ko:K09607	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M6
k59_636880_1	1095769.CAHF01000014_gene2999	4.79e-68	232.0	COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2VJGC@28216|Betaproteobacteria,472T4@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	-	-	1.2.7.8	ko:K04090	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR,TPP_enzyme_C
k59_1694824_2	1134912.AJTV01000049_gene3646	7.5e-43	141.0	COG0211@1|root,COG0211@2|Bacteria,1MZGH@1224|Proteobacteria,2UBUX@28211|Alphaproteobacteria,36YNV@31993|Methylocystaceae	28211|Alphaproteobacteria	J	Ribosomal L27 protein	rpmA	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
k59_1694824_3	1333998.M2A_0827	4.34e-45	154.0	COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,2TR5I@28211|Alphaproteobacteria,4BPWI@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GTP1_OBG,MMR_HSR1
k59_581456_1	208444.JNYY01000022_gene3240	7.63e-09	62.4	COG0457@1|root,COG3629@1|root,COG3899@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,COG3899@2|Bacteria,2I2U4@201174|Actinobacteria,4EDYG@85010|Pseudonocardiales	201174|Actinobacteria	K	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,GerE,Trans_reg_C
k59_81854_1	1120956.JHZK01000012_gene3642	1.6e-96	287.0	COG2057@1|root,COG2057@2|Bacteria,1MY3S@1224|Proteobacteria,2TUZ8@28211|Alphaproteobacteria,1JQ7Z@119043|Rhodobiaceae	28211|Alphaproteobacteria	I	Coenzyme A transferase	-	-	2.8.3.12	ko:K01040	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
k59_749059_1	98439.AJLL01000090_gene71	4.9e-14	73.2	COG0642@1|root,COG0784@1|root,COG2199@1|root,COG2202@1|root,COG2203@1|root,COG4251@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG3706@2|Bacteria,COG4251@2|Bacteria,1G09B@1117|Cyanobacteria,1JKNQ@1189|Stigonemataceae	1117|Cyanobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K11527	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
k59_749059_2	2325.TKV_c21150	1.02e-18	85.1	COG5322@1|root,COG5322@2|Bacteria,1TSXZ@1239|Firmicutes,24992@186801|Clostridia,42EPQ@68295|Thermoanaerobacterales	186801|Clostridia	S	Shikimate quinate 5-dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Shikimate_DH
k59_1082628_1	278957.ABEA03000213_gene3790	5.77e-11	62.4	COG0125@1|root,COG0125@2|Bacteria,46ST1@74201|Verrucomicrobia,3K7VY@414999|Opitutae	414999|Opitutae	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
k59_1138934_1	502025.Hoch_4517	3.34e-10	65.9	COG1034@1|root,COG3383@1|root,COG1034@2|Bacteria,COG3383@2|Bacteria,1P8MN@1224|Proteobacteria,42PT5@68525|delta/epsilon subdivisions,2WKMJ@28221|Deltaproteobacteria,2YU8F@29|Myxococcales	28221|Deltaproteobacteria	C	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region	nuoG	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdop_Fe4S4,Molybdopterin,NADH-G_4Fe-4S_3
k59_415539_1	983545.Glaag_3448	4.2e-53	191.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,1MVEU@1224|Proteobacteria,1S0IU@1236|Gammaproteobacteria,46A2Q@72275|Alteromonadaceae	1236|Gammaproteobacteria	KLT	Protein tyrosine kinase	pknB	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_10,TPR_12
k59_136979_1	517418.Ctha_2697	1.46e-54	191.0	COG0210@1|root,COG0210@2|Bacteria,1FD87@1090|Chlorobi	1090|Chlorobi	L	PFAM UvrD REP helicase	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_1527279_2	243090.RB13137	0.000365	43.5	COG2010@1|root,COG2010@2|Bacteria,2IY1J@203682|Planctomycetes	203682|Planctomycetes	C	Planctomycete cytochrome C	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,PSCyt2,PSD1
k59_972147_1	991905.SL003B_0982	5.53e-89	275.0	COG0114@1|root,COG0114@2|Bacteria,1MUQI@1224|Proteobacteria,2TQM7@28211|Alphaproteobacteria,4BP5W@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	GO:0003674,GO:0003824,GO:0004333,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006106,GO:0006108,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
k59_1694883_1	926569.ANT_14310	7.02e-49	164.0	COG0648@1|root,COG0648@2|Bacteria	2|Bacteria	L	deoxyribonuclease IV (phage-T4-induced) activity	-	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
k59_359457_1	382464.ABSI01000012_gene2198	1.02e-25	111.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,TPR_11,TPR_16,TPR_7,TPR_8,Trans_reg_C
k59_804761_1	246197.MXAN_6017	8.22e-16	78.6	COG0204@1|root,COG0204@2|Bacteria	2|Bacteria	I	Acyl-transferase	cmk	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase,Cytidylate_kin
k59_248363_1	1205680.CAKO01000035_gene262	2.58e-12	67.0	COG0526@1|root,COG0526@2|Bacteria,1RC8N@1224|Proteobacteria,2U7IW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
k59_248363_2	1095769.CAHF01000013_gene3288	2.13e-89	273.0	COG0656@1|root,COG0656@2|Bacteria,1MX6S@1224|Proteobacteria,2VNCV@28216|Betaproteobacteria,475IH@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_81910_1	1120936.KB907210_gene5588	1.53e-12	68.2	COG3842@1|root,COG3842@2|Bacteria,2H2JF@201174|Actinobacteria,4EH68@85012|Streptosporangiales	201174|Actinobacteria	P	TOBE domain	modC	-	3.6.3.29	ko:K02017,ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran,TOBE
k59_415553_1	1121428.DESHY_30083___1	1.23e-62	211.0	COG4231@1|root,COG4231@2|Bacteria,1TNY3@1239|Firmicutes,247U1@186801|Clostridia,260MU@186807|Peptococcaceae	186801|Clostridia	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,POR_N,TPP_enzyme_C
k59_81917_1	1267534.KB906760_gene1522	1.28e-22	103.0	COG0577@1|root,COG0577@2|Bacteria,3Y3K0@57723|Acidobacteria,2JHKX@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_1305391_1	331869.BAL199_06614	1.86e-58	197.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TT1G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_1028417_1	1313172.YM304_26040	8.61e-70	218.0	COG0638@1|root,COG0638@2|Bacteria,2GKZ1@201174|Actinobacteria,4CMY5@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	prcA	-	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
k59_248377_2	44056.XP_009042410.1	5.73e-06	49.3	COG0706@1|root,KOG1239@2759|Eukaryota	2759|Eukaryota	U	membrane insertase activity	ALB3.1	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006605,GO:0006612,GO:0006810,GO:0006886,GO:0006996,GO:0008104,GO:0008150,GO:0009507,GO:0009534,GO:0009535,GO:0009536,GO:0009579,GO:0009657,GO:0009658,GO:0009668,GO:0009987,GO:0010027,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0017038,GO:0019904,GO:0022607,GO:0031976,GO:0031984,GO:0032991,GO:0033036,GO:0033365,GO:0034357,GO:0034613,GO:0042651,GO:0042886,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043933,GO:0044085,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044436,GO:0044444,GO:0044446,GO:0044464,GO:0044743,GO:0045036,GO:0045038,GO:0045184,GO:0046907,GO:0050789,GO:0050793,GO:0050794,GO:0051179,GO:0051234,GO:0051259,GO:0051291,GO:0051641,GO:0051649,GO:0055035,GO:0055085,GO:0061024,GO:0065002,GO:0065003,GO:0065007,GO:0070206,GO:0070208,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0072594,GO:0072596,GO:0072598,GO:0072657,GO:0090150,GO:0090342	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP
k59_192787_1	1380394.JADL01000005_gene5676	2.14e-66	210.0	COG2175@1|root,COG2175@2|Bacteria,1MVI6@1224|Proteobacteria,2TVHF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	PFAM Taurine catabolism dioxygenase TauD, TfdA family	-	-	-	-	-	-	-	-	-	-	-	-	TauD
k59_192787_2	1121106.JQKB01000151_gene1685	1.05e-07	50.4	COG1917@1|root,COG1917@2|Bacteria,1NAFB@1224|Proteobacteria	1224|Proteobacteria	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_3
k59_1305397_1	550540.Fbal_1772	2.61e-10	60.5	COG0589@1|root,COG0589@2|Bacteria,1MVZS@1224|Proteobacteria,1S9R4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	universal stress protein	-	-	-	ko:K14055	-	-	-	-	ko00000	-	-	-	Usp
k59_1082676_1	913865.DOT_5223	1.64e-24	99.0	COG1832@1|root,COG1832@2|Bacteria,1V7C7@1239|Firmicutes,24P0N@186801|Clostridia,2632C@186807|Peptococcaceae	186801|Clostridia	S	CoA-binding protein	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
k59_1138974_1	485913.Krac_1540	0.000261	42.4	COG0262@1|root,COG0262@2|Bacteria	2|Bacteria	H	dihydrofolate reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
k59_972178_1	1121468.AUBR01000038_gene1977	1.55e-25	112.0	COG2199@1|root,COG2202@1|root,COG2202@2|Bacteria,COG3706@2|Bacteria,1V9Y7@1239|Firmicutes,24A8B@186801|Clostridia,42FTQ@68295|Thermoanaerobacterales	186801|Clostridia	T	Response regulator receiver	-	-	2.7.7.65	ko:K18967	-	-	-	-	ko00000,ko01000,ko02000	9.B.34.1.1	-	-	GGDEF,PAS,PAS_8,PAS_9,PocR,Response_reg
k59_1472331_1	1123239.KB898623_gene1449	2.17e-34	133.0	COG0733@1|root,COG0733@2|Bacteria,1TP6B@1239|Firmicutes,4HAAI@91061|Bacilli	91061|Bacilli	S	Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family	-	-	-	ko:K03308	-	-	-	-	ko00000	2.A.22.4,2.A.22.5	-	-	SNF
k59_472512_1	886293.Sinac_6886	1.65e-95	299.0	COG0843@1|root,COG0843@2|Bacteria,2IXCQ@203682|Planctomycetes	203682|Planctomycetes	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_1028445_1	926569.ANT_08710	4.41e-56	193.0	COG0358@1|root,COG0358@2|Bacteria,2G65X@200795|Chloroflexi	200795|Chloroflexi	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
k59_636991_1	1379698.RBG1_1C00001G1125	2.27e-63	202.0	COG1692@1|root,COG1692@2|Bacteria,2NNW9@2323|unclassified Bacteria	2|Bacteria	S	YmdB-like protein	ymdB	GO:0003674,GO:0003824,GO:0004112,GO:0004113,GO:0008081,GO:0016787,GO:0016788,GO:0042578	-	ko:K02029,ko:K02030,ko:K09769	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	YmdB
k59_749140_2	706587.Desti_4798	1e-34	126.0	COG1809@1|root,COG1809@2|Bacteria,1MUQY@1224|Proteobacteria	1224|Proteobacteria	S	(2R)-phospho-3-sulfolactate synthase (ComA)	-	-	-	-	-	-	-	-	-	-	-	-	ComA
k59_249572_1	710696.Intca_2247	3.94e-15	78.6	COG0305@1|root,COG0305@2|Bacteria,2I9NH@201174|Actinobacteria,4FER9@85021|Intrasporangiaceae	201174|Actinobacteria	L	KaiC	-	-	-	-	-	-	-	-	-	-	-	-	DnaB_C
k59_750252_1	1121272.KB903250_gene2734	7.96e-96	291.0	COG1260@1|root,COG1260@2|Bacteria,2GJVN@201174|Actinobacteria	201174|Actinobacteria	I	Myo-inositol-1-phosphate synthase	-	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth,NAD_binding_5
k59_473851_2	926569.ANT_15100	2.73e-31	112.0	COG3118@1|root,COG3118@2|Bacteria,2G6U1@200795|Chloroflexi	200795|Chloroflexi	O	Belongs to the thioredoxin family	-	GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
k59_638162_1	1121440.AUMA01000009_gene685	4.47e-21	95.9	COG0683@1|root,COG0683@2|Bacteria,1MWQB@1224|Proteobacteria,42PN2@68525|delta/epsilon subdivisions,2WM53@28221|Deltaproteobacteria,2M994@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	PFAM Extracellular ligand-binding receptor	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_860232_1	404380.Gbem_1696	1.52e-28	110.0	COG1595@1|root,COG1595@2|Bacteria,1PEU8@1224|Proteobacteria,42T76@68525|delta/epsilon subdivisions,2WPVH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_1195220_2	926569.ANT_03880	7.13e-35	125.0	COG5615@1|root,COG5615@2|Bacteria	2|Bacteria	L	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	CopD
k59_1473553_1	266117.Rxyl_0200	2.8e-59	189.0	COG0684@1|root,COG0684@2|Bacteria,2I8VQ@201174|Actinobacteria,4CSRQ@84995|Rubrobacteria	84995|Rubrobacteria	H	Aldolase/RraA	-	-	4.1.3.17	ko:K10218	ko00362,ko00660,ko01120,map00362,map00660,map01120	-	R00008,R00350	RC00067,RC00502,RC01205	ko00000,ko00001,ko01000	-	-	-	RraA-like
k59_1638638_1	953739.SVEN_2536	7.05e-37	141.0	COG0507@1|root,COG0507@2|Bacteria,2GJRK@201174|Actinobacteria	201174|Actinobacteria	L	DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity	recD2	-	3.1.11.5	ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_30,HHH_4,HHH_5,UvrD_C_2
k59_1750217_1	5141.EFNCRP00000006077	2.42e-25	106.0	COG1228@1|root,2QRDE@2759|Eukaryota,38I4F@33154|Opisthokonta,3P0UR@4751|Fungi,3QP2S@4890|Ascomycota,2150X@147550|Sordariomycetes,3UDUF@5139|Sordariales,3UFRX@5148|Sordariaceae	4751|Fungi	G	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_1473556_1	468059.AUHA01000004_gene2346	1.06e-99	309.0	COG2133@1|root,COG2133@2|Bacteria,4NF0B@976|Bacteroidetes,1IVAH@117747|Sphingobacteriia	976|Bacteroidetes	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6,GSDH,Ig_2,Malectin,PKD,VCBS,fn3
k59_27689_1	398720.MED217_11914	1.71e-84	272.0	COG2234@1|root,COG2234@2|Bacteria,4NI5W@976|Bacteroidetes,1HXHX@117743|Flavobacteriia,2XK11@283735|Leeuwenhoekiella	976|Bacteroidetes	S	Transferrin receptor-like dimerisation domain	-	-	3.4.17.21	ko:K01301	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PA,Peptidase_M28,TFR_dimer
k59_1750223_1	1382356.JQMP01000001_gene1144	6.54e-67	220.0	COG4177@1|root,COG4177@2|Bacteria,2G6D8@200795|Chloroflexi,27Z3V@189775|Thermomicrobia	189775|Thermomicrobia	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_1084081_1	67315.JOBD01000020_gene7455	2.91e-26	110.0	COG2159@1|root,COG2159@2|Bacteria,2GP75@201174|Actinobacteria	201174|Actinobacteria	S	Amidohydrolase	-	-	4.1.1.52	ko:K22213	-	-	-	-	ko00000,ko01000	-	-	-	Amidohydro_2
k59_360735_1	391593.RCCS2_08689	9.76e-116	363.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,2TTPX@28211|Alphaproteobacteria,2P24C@2433|Roseobacter	28211|Alphaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	fdhF	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_83240_1	1293054.HSACCH_02064	1.19e-09	66.6	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1TS9U@1239|Firmicutes,249VR@186801|Clostridia,3WADZ@53433|Halanaerobiales	186801|Clostridia	S	DNA internalization-related competence protein ComEC Rec2	comEC	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
k59_473898_1	635013.TherJR_2534	1.11e-37	143.0	COG1530@1|root,COG1530@2|Bacteria,1TQS4@1239|Firmicutes,247QV@186801|Clostridia,260R1@186807|Peptococcaceae	186801|Clostridia	J	TIGRFAM ribonuclease, Rne Rng family	rng	-	-	ko:K08301	-	-	-	-	ko00000,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1,TRAM
k59_194182_1	686340.Metal_1890	5.73e-41	140.0	COG0517@1|root,COG0517@2|Bacteria,1QJRF@1224|Proteobacteria,1THSQ@1236|Gammaproteobacteria,1XFJQ@135618|Methylococcales	135618|Methylococcales	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_595996_1	1380394.JADL01000011_gene3988	8.41e-76	248.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria,2JQ9H@204441|Rhodospirillales	204441|Rhodospirillales	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_1486897_1	324925.Ppha_0986	4.12e-59	185.0	COG1396@1|root,COG1396@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
k59_205833_1	1463885.KL578374_gene4201	3.65e-16	79.0	COG0714@1|root,COG0714@2|Bacteria,2GK07@201174|Actinobacteria	201174|Actinobacteria	S	associated with various cellular activities	yeaC	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
k59_1375653_1	439292.Bsel_2593	6.01e-05	50.4	COG3639@1|root,COG3639@2|Bacteria,1TQ73@1239|Firmicutes,4HBI5@91061|Bacilli,26NZQ@186821|Sporolactobacillaceae	91061|Bacilli	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02042	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	BPD_transp_1
k59_709125_1	665577.JH993790_gene2132	1.25e-119	351.0	COG3396@1|root,COG3396@2|Bacteria,2GMQ3@201174|Actinobacteria	201174|Actinobacteria	S	Phenylacetate-CoA oxygenase	paaA	-	1.14.13.149	ko:K02609	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001,ko01000	-	-	-	PaaA_PaaC
k59_374155_1	1232437.KL662006_gene4388	4.17e-16	74.3	2C477@1|root,32RDF@2|Bacteria,1RKW1@1224|Proteobacteria,42SWN@68525|delta/epsilon subdivisions,2WP88@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	DGC domain	-	-	-	-	-	-	-	-	-	-	-	-	DGC
k59_374155_2	526222.Desal_2901	3.73e-22	91.7	COG1595@1|root,COG1595@2|Bacteria,1PEU8@1224|Proteobacteria,42T76@68525|delta/epsilon subdivisions,2WPVH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_1207910_1	1207063.P24_15539	5.13e-48	165.0	COG0589@1|root,COG0589@2|Bacteria,1RATR@1224|Proteobacteria,2U6UI@28211|Alphaproteobacteria,2JZR5@204441|Rhodospirillales	204441|Rhodospirillales	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_650290_1	1313172.YM304_07450	4.56e-72	239.0	COG3808@1|root,COG3808@2|Bacteria,2GN8B@201174|Actinobacteria	201174|Actinobacteria	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
k59_763003_1	1128421.JAGA01000003_gene3503	1.34e-45	162.0	COG0766@1|root,COG0766@2|Bacteria,2NNUV@2323|unclassified Bacteria	2|Bacteria	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase,HTH_3
k59_374158_1	1047013.AQSP01000142_gene242	6.89e-27	111.0	COG2511@1|root,COG2511@2|Bacteria	2|Bacteria	J	GatB/GatE catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	GatB_N
k59_709151_1	1382304.JNIL01000001_gene316	4.94e-07	52.0	COG1884@1|root,COG1884@2|Bacteria,1TQAD@1239|Firmicutes,4H9QB@91061|Bacilli,277YF@186823|Alicyclobacillaceae	91061|Bacilli	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
k59_709151_2	1121930.AQXG01000005_gene720	4.74e-21	86.3	COG2331@1|root,COG2331@2|Bacteria,4P8SQ@976|Bacteroidetes	976|Bacteroidetes	S	Putative regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
k59_1486938_1	1206744.BAGL01000033_gene220	9.36e-102	305.0	COG1788@1|root,COG1788@2|Bacteria,2I9F6@201174|Actinobacteria,4FZB8@85025|Nocardiaceae	201174|Actinobacteria	I	Coenzyme A transferase	catI	-	2.8.3.12	ko:K01039	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
k59_151132_1	1207063.P24_09531	2.13e-73	231.0	COG0697@1|root,COG0697@2|Bacteria,1MWSU@1224|Proteobacteria,2TSWT@28211|Alphaproteobacteria,2JSPC@204441|Rhodospirillales	204441|Rhodospirillales	EG	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_487388_1	1122239.AULS01000021_gene2486	6.77e-11	68.2	COG0577@1|root,COG0577@2|Bacteria,2HW2M@201174|Actinobacteria	201174|Actinobacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1266306_1	1210045.ALNP01000031_gene2639	9.44e-29	115.0	COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,2GJBZ@201174|Actinobacteria	201174|Actinobacteria	M	Belongs to the peptidase M50B family	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Peptidase_M50
k59_709172_1	1304865.JAGF01000001_gene2921	4.27e-81	251.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4F0HN@85016|Cellulomonadaceae	201174|Actinobacteria	V	TIGRFAM daunorubicin resistance ABC transporter ATPase subunit	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC_tran
k59_205875_1	102129.Lepto7375DRAFT_1209	2.79e-15	76.3	COG0500@1|root,COG1134@1|root,COG0500@2|Bacteria,COG1134@2|Bacteria,1GQG8@1117|Cyanobacteria	1117|Cyanobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
k59_763028_1	1120979.ATVB01000007_gene1138	7.45e-10	65.9	COG1577@1|root,COG1577@2|Bacteria,2IAQ7@201174|Actinobacteria,4CZZJ@85004|Bifidobacteriales	201174|Actinobacteria	I	GHMP kinases C terminal	mvk	-	2.7.1.36	ko:K00869	ko00900,ko01100,ko01110,ko01130,ko04146,map00900,map01100,map01110,map01130,map04146	M00095	R02245	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
k59_763028_2	1459636.NTE_02596	6.24e-10	58.9	COG1355@1|root,arCOG01728@2157|Archaea,41S9D@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Belongs to the MEMO1 family	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
k59_933193_1	1125863.JAFN01000001_gene2793	9.29e-20	97.1	COG2010@1|root,COG3258@1|root,COG2010@2|Bacteria,COG3258@2|Bacteria,1RJJ2@1224|Proteobacteria,42SCM@68525|delta/epsilon subdivisions,2WPS4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Cytochrome c	pcmF	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
k59_1486971_1	1121943.KB899994_gene936	4.41e-05	50.8	COG4774@1|root,COG4774@2|Bacteria,1QV5G@1224|Proteobacteria,1T298@1236|Gammaproteobacteria,1XRSG@135619|Oceanospirillales	135619|Oceanospirillales	P	Outer membrane protein beta-barrel family	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k59_1430562_1	351348.Maqu_1605	4.52e-56	181.0	COG0714@1|root,COG0714@2|Bacteria,1MV5I@1224|Proteobacteria,1RQ62@1236|Gammaproteobacteria,465MV@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	COG0714 MoxR-like ATPases	HA62_21050	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_5
k59_1430562_2	351348.Maqu_1606	3.01e-05	47.8	COG2304@1|root,COG2304@2|Bacteria,1MVJ2@1224|Proteobacteria,1RMUF@1236|Gammaproteobacteria,464I4@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	protein containing a von Willebrand factor type A (vWA) domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_3
k59_205903_1	56780.SYN_03026	3.59e-61	204.0	COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,42M04@68525|delta/epsilon subdivisions,2WJJD@28221|Deltaproteobacteria,2MQUI@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
k59_540858_1	479435.Kfla_0870	2.69e-07	56.6	COG1680@1|root,COG1680@2|Bacteria,2GN1H@201174|Actinobacteria,4DS2A@85009|Propionibacteriales	201174|Actinobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_1375745_1	1121439.dsat_1679	1.36e-107	324.0	COG0701@1|root,COG0701@2|Bacteria,1MUN8@1224|Proteobacteria,42N6E@68525|delta/epsilon subdivisions,2WJXG@28221|Deltaproteobacteria,2M9VF@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Predicted permease	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1
k59_873958_1	216591.BCAM2367	8.84e-46	173.0	COG4772@1|root,COG4772@2|Bacteria,1MXJU@1224|Proteobacteria,2VN9X@28216|Betaproteobacteria,1K2NQ@119060|Burkholderiaceae	28216|Betaproteobacteria	P	TonB-dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k59_1598056_1	272624.lpg0378	1.91e-06	54.7	COG2170@1|root,COG2170@2|Bacteria,1MY35@1224|Proteobacteria,1SKSY@1236|Gammaproteobacteria,1JDTV@118969|Legionellales	118969|Legionellales	H	Glutamate-cysteine ligase family 2(GCS2)	-	-	-	-	-	-	-	-	-	-	-	-	GCS2
k59_1320975_1	879212.DespoDRAFT_01745	4.46e-36	140.0	COG0744@1|root,COG5009@1|root,COG0744@2|Bacteria,COG5009@2|Bacteria,1NRPB@1224|Proteobacteria,42ZB6@68525|delta/epsilon subdivisions,2WTUW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Transglycosylase	-	-	-	-	-	-	-	-	-	-	-	-	Transgly
k59_487443_1	279714.FuraDRAFT_3731	1.93e-22	96.3	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2VJ5H@28216|Betaproteobacteria,2KRY5@206351|Neisseriales	206351|Neisseriales	L	Transposase IS116/IS110/IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_20
k59_873981_1	331869.BAL199_25379	2.49e-39	142.0	COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,2TS3R@28211|Alphaproteobacteria,4BPBB@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
k59_873981_2	1110502.TMO_1981	2.42e-26	108.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,2TR4E@28211|Alphaproteobacteria,2JQC9@204441|Rhodospirillales	204441|Rhodospirillales	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_1320991_1	349163.Acry_3080	2.19e-07	56.2	COG0586@1|root,COG0586@2|Bacteria,1N958@1224|Proteobacteria,2UY37@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
k59_1266387_1	489825.LYNGBM3L_21480	1.88e-26	100.0	2DNS7@1|root,32YWC@2|Bacteria,1G8QD@1117|Cyanobacteria,1HGCH@1150|Oscillatoriales	1117|Cyanobacteria	J	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
k59_1266387_2	1499967.BAYZ01000167_gene6735	4.46e-26	100.0	COG0454@1|root,COG0456@2|Bacteria,2NS1J@2323|unclassified Bacteria	2|Bacteria	K	FR47-like protein	argO	-	2.3.1.1	ko:K03826,ko:K22477	ko00220,ko01210,ko01230,map00220,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_10
k59_873996_1	864051.BurJ1DRAFT_2770	1.68e-64	214.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2W9GX@28216|Betaproteobacteria,1KNPZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_320086_1	1304872.JAGC01000003_gene2868	9.55e-75	250.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,43EBY@68525|delta/epsilon subdivisions,2X7W0@28221|Deltaproteobacteria,2MHDJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	V	AcrB/AcrD/AcrF family	-	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	-	ACR_tran
k59_1651025_1	83406.HDN1F_15990	4.56e-31	122.0	COG1884@1|root,COG2185@1|root,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,1RSHX@1236|Gammaproteobacteria,1J4JG@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	COG1884 Methylmalonyl-CoA mutase, N-terminal domain subunit	-	-	5.4.99.2,5.4.99.63	ko:K01847,ko:K14447	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00376,M00741	R00833,R09292	RC00395,RC02835	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,MM_CoA_mutase
k59_1651025_2	83406.HDN1F_15980	1.73e-07	54.3	COG1703@1|root,COG1703@2|Bacteria,1MVI0@1224|Proteobacteria,1RP15@1236|Gammaproteobacteria,1J4Q4@118884|unclassified Gammaproteobacteria	1224|Proteobacteria	E	periplasmic protein kinase ArgK and related GTPases of G3E family	-	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
k59_151242_1	634499.EpC_23160	8.21e-37	134.0	COG3907@1|root,COG3907@2|Bacteria,1MU4M@1224|Proteobacteria,1RQ2Y@1236|Gammaproteobacteria,3X669@551|Erwinia	1236|Gammaproteobacteria	S	PAP2 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
k59_429689_2	1385513.N780_08945	5.94e-65	209.0	COG1028@1|root,COG1028@2|Bacteria,1TRQB@1239|Firmicutes,4HAY3@91061|Bacilli,2YBNH@289201|Pontibacillus	91061|Bacilli	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_429691_1	1343158.SACS_1560	1.45e-74	244.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,2TQUX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
k59_1710431_1	1122135.KB893134_gene3933	4.68e-93	280.0	COG0518@1|root,COG0518@2|Bacteria,1Q2PQ@1224|Proteobacteria,2U196@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	glutamine amidotransferase	-	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase
k59_151261_2	1319815.HMPREF0202_00361	4.71e-42	147.0	COG1043@1|root,COG1043@2|Bacteria,378KQ@32066|Fusobacteria	32066|Fusobacteria	M	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxA	-	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Acetyltransf_11,Hexapep
k59_989460_2	1121448.DGI_1988	4.75e-39	137.0	COG1522@1|root,COG1522@2|Bacteria,1MXVU@1224|Proteobacteria,42S5E@68525|delta/epsilon subdivisions,2WNB1@28221|Deltaproteobacteria,2MA2B@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	SMART Transcription regulator, AsnC-type	-	-	-	ko:K03718,ko:K03719	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
k59_935190_1	330214.NIDE1095	9.41e-31	117.0	COG0502@1|root,COG0502@2|Bacteria,3J0I9@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism	bioB	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	BATS,Radical_SAM
k59_935190_2	1123373.ATXI01000014_gene1	6.96e-22	87.4	COG1758@1|root,COG1758@2|Bacteria,2GHZJ@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	rpoZ	-	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
k59_376258_2	985255.APHJ01000023_gene2683	1.02e-31	121.0	COG0714@1|root,COG0714@2|Bacteria,4NDVZ@976|Bacteroidetes,1HY4Z@117743|Flavobacteriia,2P7DW@244698|Gillisia	976|Bacteroidetes	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
k59_764630_1	446462.Amir_7062	3.85e-34	137.0	COG0702@1|root,COG0702@2|Bacteria,2GIZA@201174|Actinobacteria,4DX7H@85010|Pseudonocardiales	201174|Actinobacteria	GM	Protein of unknown function (DUF2867)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2867,NAD_binding_10,TspO_MBR
k59_153170_1	1089551.KE386572_gene2510	5.38e-05	50.8	COG0477@1|root,COG2814@2|Bacteria,1MUXC@1224|Proteobacteria,2TRR7@28211|Alphaproteobacteria,4BQYS@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_263575_1	1158762.KB898043_gene1077	8.07e-19	90.1	COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,1RN13@1236|Gammaproteobacteria,1WWJ0@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine	mtaD	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
k59_1155137_1	861299.J421_2495	2.7e-47	161.0	COG2148@1|root,COG2148@2|Bacteria,1ZSW2@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Bacterial sugar transferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf
k59_1764198_1	1267535.KB906767_gene4695	4.2e-108	325.0	COG0719@1|root,COG0719@2|Bacteria,3Y2IX@57723|Acidobacteria	57723|Acidobacteria	O	Uncharacterized protein family (UPF0051)	-	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
k59_711071_1	861299.J421_2773	2.39e-17	75.1	COG0051@1|root,COG0051@2|Bacteria,1ZTS9@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Involved in the binding of tRNA to the ribosomes	rpsJ	-	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
k59_711071_2	644968.DFW101_3204	9.94e-22	94.4	COG0087@1|root,COG0087@2|Bacteria,1MUST@1224|Proteobacteria,42NV2@68525|delta/epsilon subdivisions,2WNJ1@28221|Deltaproteobacteria,2M9CC@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
k59_1155166_2	696281.Desru_2698	9.98e-25	106.0	COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,26166@186807|Peptococcaceae	186801|Clostridia	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Fer4_7,NAD_binding_8,Pyr_redox_2
k59_1377784_1	378806.STAUR_4692	1.96e-08	62.0	COG0457@1|root,COG0515@1|root,COG3899@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG3899@2|Bacteria,1PEJF@1224|Proteobacteria,433Y5@68525|delta/epsilon subdivisions,2X2KM@28221|Deltaproteobacteria,2YXZ5@29|Myxococcales	28221|Deltaproteobacteria	KLT	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Pkinase
k59_542764_1	861299.J421_3150	1.28e-69	220.0	COG0714@1|root,COG0714@2|Bacteria,1ZT94@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
k59_1764231_1	522772.Dacet_1487	1.95e-78	264.0	COG1924@1|root,COG3580@1|root,COG3581@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,COG3581@2|Bacteria,2GEWG@200930|Deferribacteres	200930|Deferribacteres	I	BadF/BadG/BcrA/BcrD ATPase family	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229,HGD-D
k59_1652806_1	42256.RradSPS_0766	1.32e-05	49.3	COG1846@1|root,COG1846@2|Bacteria,2GUZX@201174|Actinobacteria	201174|Actinobacteria	K	MarR family	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
k59_1652806_2	1297863.APJF01000013_gene4026	0.000998	41.2	COG2114@1|root,COG2267@1|root,COG2114@2|Bacteria,COG2267@2|Bacteria,1QXEH@1224|Proteobacteria,2TX96@28211|Alphaproteobacteria,3K6W1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IT	Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,FHA,Guanylate_cyc
k59_263633_1	1150626.PHAMO_270071	3.13e-34	127.0	COG0119@1|root,COG0119@2|Bacteria,1MUMX@1224|Proteobacteria,2TT1R@28211|Alphaproteobacteria,2JPU7@204441|Rhodospirillales	204441|Rhodospirillales	E	COG0119 Isopropylmalate homocitrate citramalate synthases	-	-	4.1.3.4	ko:K01640	ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146	M00036,M00088	R01360,R08090	RC00502,RC00503,RC01118,RC01946	ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
k59_263633_2	1341181.FLJC2902T_06790	4.34e-13	69.3	COG1960@1|root,COG1960@2|Bacteria,4NFD4@976|Bacteroidetes,1HWQD@117743|Flavobacteriia,2NTSV@237|Flavobacterium	976|Bacteroidetes	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_1712367_1	530564.Psta_2443	1.27e-05	47.0	COG4911@1|root,COG4911@2|Bacteria,2J02T@203682|Planctomycetes	203682|Planctomycetes	S	conserved protein (DUF2203)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2203
k59_1099570_1	1237149.C900_02707	7.13e-47	156.0	COG2050@1|root,COG2050@2|Bacteria,4NQ15@976|Bacteroidetes	976|Bacteroidetes	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
k59_1099570_2	1270196.JCKI01000004_gene1179	5.28e-07	51.2	COG2126@1|root,COG2126@2|Bacteria,4NEX1@976|Bacteroidetes,1IR8M@117747|Sphingobacteriia	976|Bacteroidetes	J	Ion transport protein	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans
k59_489334_1	1047013.AQSP01000142_gene242	2.22e-23	103.0	COG2511@1|root,COG2511@2|Bacteria	2|Bacteria	J	GatB/GatE catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	GatB_N
k59_376343_1	1265313.HRUBRA_00108	6.14e-109	334.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MWGR@1224|Proteobacteria,1RR88@1236|Gammaproteobacteria,1J5WK@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	EU	COG1506 Dipeptidyl aminopeptidases acylaminoacyl-peptidases	-	-	-	-	-	-	-	-	-	-	-	-	DPPIV_N,PD40,Peptidase_S9
k59_764701_1	458817.Shal_1688	7.97e-62	197.0	COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,1RMD4@1236|Gammaproteobacteria,2Q9MQ@267890|Shewanellaceae	1236|Gammaproteobacteria	U	PFAM MotA TolQ ExbB proton channel	tolQ	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0015893,GO:0016020,GO:0016021,GO:0017038,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0032153,GO:0033036,GO:0042221,GO:0042493,GO:0042886,GO:0042891,GO:0043213,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0050896,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03562	ko01120,map01120	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	MotA_ExbB
k59_207446_1	246197.MXAN_5371	4.26e-48	174.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,42MQS@68525|delta/epsilon subdivisions,2WINP@28221|Deltaproteobacteria,2YU7W@29|Myxococcales	28221|Deltaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	fadJ	-	1.1.1.35,4.2.1.17,5.1.2.3	ko:K01782	ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
k59_1667589_1	1122929.KB908217_gene198	1.32e-83	266.0	COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,2TS6C@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_1555638_1	1120948.KB903240_gene4148	8.23e-54	183.0	COG4638@1|root,COG4638@2|Bacteria,2IDCR@201174|Actinobacteria,4EEXW@85010|Pseudonocardiales	201174|Actinobacteria	P	Rieske [2Fe-2S] domain	-	-	-	ko:K15060	ko00627,ko01120,map00627,map01120	-	R09275	RC00392,RC01533	ko00000,ko00001	-	-	-	Rieske
k59_1555640_1	1411123.JQNH01000001_gene502	1.33e-05	48.5	COG2358@1|root,COG2358@2|Bacteria,1R3ZR@1224|Proteobacteria,2TSND@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	transport system periplasmic component	MA20_27285	-	-	-	-	-	-	-	-	-	-	-	NMT1_3
k59_1667632_1	945713.IALB_0798	3.09e-41	148.0	COG0492@1|root,COG0492@2|Bacteria	2|Bacteria	C	ferredoxin-NADP+ reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2,FAD_oxidored,Pyr_redox_2,Thioredoxin_3,cNMP_binding
k59_666297_1	111780.Sta7437_1737	5.67e-30	107.0	COG1598@1|root,COG1598@2|Bacteria,1G985@1117|Cyanobacteria,3VKSV@52604|Pleurocapsales	1117|Cyanobacteria	S	HicB_like antitoxin of bacterial toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	HicB_lk_antitox
k59_666297_2	187272.Mlg_2561	1.48e-31	112.0	COG1476@1|root,COG1476@2|Bacteria,1QWRE@1224|Proteobacteria,1T2XD@1236|Gammaproteobacteria,1X0ZS@135613|Chromatiales	135613|Chromatiales	K	Cro/C1-type HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
k59_1555688_1	420324.KI912006_gene8659	6.68e-86	274.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2TR8H@28211|Alphaproteobacteria,1JTBI@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	PFAM biotin lipoyl attachment domain-containing protein	lpdA	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim
k59_610507_1	671143.DAMO_2142	1.13e-102	327.0	COG0458@1|root,COG0458@2|Bacteria,2NNPB@2323|unclassified Bacteria	2|Bacteria	EF	Carbamoyl-phosphate synthetase ammonia chain	carB	GO:0000050,GO:0000166,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016053,GO:0016597,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0071941,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b0033,iBWG_1329.BWG_0031,iECDH10B_1368.ECDH10B_0034,iECDH1ME8569_1439.ECDH1ME8569_0031,iECUMN_1333.ECUMN_0034,iEcDH1_1363.EcDH1_3566,iJN746.PP_4723,iJO1366.b0033,iJR904.b0033,iPC815.YPO0482,iY75_1357.Y75_RS00170,iYL1228.KPN_00041	CPSase_L_D2,CPSase_L_D3,MGS
k59_555919_1	314230.DSM3645_07186	1.39e-78	248.0	COG1282@1|root,COG1282@2|Bacteria,2IYIA@203682|Planctomycetes	203682|Planctomycetes	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntB	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
k59_220112_1	637389.Acaty_c0880	6.51e-26	100.0	COG1416@1|root,COG1416@2|Bacteria,1NBH7@1224|Proteobacteria,1SF4X@1236|Gammaproteobacteria,2NDB2@225057|Acidithiobacillales	225057|Acidithiobacillales	S	DsrE/DsrF-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE
k59_220112_2	9593.ENSGGOP00000028702	5.09e-20	87.4	COG1804@1|root,KOG3957@2759|Eukaryota,38CWZ@33154|Opisthokonta,3BB7M@33208|Metazoa,3D0JC@33213|Bilateria,4838Z@7711|Chordata,48ZTZ@7742|Vertebrata,3JBNC@40674|Mammalia,35AGG@314146|Euarchontoglires,4MJRY@9443|Primates,4MVFA@9604|Hominidae	33208|Metazoa	I	CoA-transferase family III	SUGCT	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0008410,GO:0016740,GO:0016782,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0047369	2.8.3.13	ko:K18703	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
k59_1667778_1	1345697.M493_09070	3e-23	98.6	COG1349@1|root,COG1349@2|Bacteria,1TSHY@1239|Firmicutes,4HD6Y@91061|Bacilli,1WGS5@129337|Geobacillus	91061|Bacilli	K	DeoR C terminal sensor domain	yulB	-	-	ko:K22103	-	-	-	-	ko00000,ko03000	-	-	-	DeoRC,HTH_DeoR
k59_610639_1	1232410.KI421424_gene1814	5.72e-84	264.0	COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,43CGH@68525|delta/epsilon subdivisions,2WJ3J@28221|Deltaproteobacteria,43TNM@69541|Desulfuromonadales	28221|Deltaproteobacteria	EQ	Hydantoinase B/oxoprolinase	hyuB	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
k59_666567_1	519441.Smon_0313	9.1e-16	78.2	COG0324@1|root,COG0324@2|Bacteria,378AW@32066|Fusobacteria	32066|Fusobacteria	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
k59_666570_1	215803.DB30_0409	1.64e-21	100.0	COG5184@1|root,COG5184@2|Bacteria,1R504@1224|Proteobacteria,42QHC@68525|delta/epsilon subdivisions,2WKUI@28221|Deltaproteobacteria,2YY0K@29|Myxococcales	28221|Deltaproteobacteria	DZ	Putative metal-binding motif	-	-	-	-	-	-	-	-	-	-	-	-	Cu-binding_MopE,RCC1
k59_1555932_1	635013.TherJR_1549	1.38e-45	159.0	COG4974@1|root,COG4974@2|Bacteria,1TPQB@1239|Firmicutes,25C3N@186801|Clostridia,260TU@186807|Peptococcaceae	186801|Clostridia	D	Belongs to the 'phage' integrase family. XerC subfamily	xerC	-	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_276988_1	1121035.AUCH01000005_gene59	2e-90	289.0	COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,2VH74@28216|Betaproteobacteria,2KVA2@206389|Rhodocyclales	206389|Rhodocyclales	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_220420_1	397287.C807_00772	2.16e-30	119.0	COG0696@1|root,COG0696@2|Bacteria,1TPM4@1239|Firmicutes,247JG@186801|Clostridia,27JMY@186928|unclassified Lachnospiraceae	186801|Clostridia	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmI	-	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,Phosphodiest,iPGM_N
k59_220420_2	56780.SYN_01339	1.25e-09	56.2	COG0799@1|root,COG0799@2|Bacteria,1MZEF@1224|Proteobacteria,42VN5@68525|delta/epsilon subdivisions,2WRGG@28221|Deltaproteobacteria,2MQM6@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
k59_220432_2	1280674.AUJK01000008_gene390	6.4e-12	65.1	COG0629@1|root,COG0629@2|Bacteria,4NQBK@976|Bacteroidetes,2FT5G@200643|Bacteroidia	976|Bacteroidetes	L	Single-stranded DNA-binding protein	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
k59_1556124_1	504472.Slin_6185	1.66e-24	107.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,4NETS@976|Bacteroidetes,47KF8@768503|Cytophagia	976|Bacteroidetes	EU	Dipeptidyl peptidase IV (DPP IV) N-terminal region	dpp	-	3.4.14.5	ko:K01278	ko04974,map04974	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	DPPIV_N,Peptidase_S9
k59_220487_1	926569.ANT_06600	7.9e-47	171.0	COG2203@1|root,COG5002@1|root,COG2203@2|Bacteria,COG5002@2|Bacteria,2G7NF@200795|Chloroflexi	200795|Chloroflexi	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA
k59_220496_1	1267533.KB906733_gene3362	8.56e-12	70.1	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,3Y7E7@57723|Acidobacteria,2JKGS@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
k59_277141_2	864069.MicloDRAFT_00057010	6.56e-05	46.6	2CBFC@1|root,32RYI@2|Bacteria,1N0T4@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_666790_1	1379270.AUXF01000005_gene662	5.08e-31	112.0	COG1734@1|root,COG1734@2|Bacteria,1ZTP9@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Prokaryotic dksA/traR C4-type zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-dskA_traR
k59_666790_2	861299.J421_3050	1.39e-39	140.0	COG0597@1|root,COG0597@2|Bacteria,1ZTWA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	-	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
k59_277179_1	1499967.BAYZ01000036_gene2418	3.04e-89	283.0	COG0438@1|root,COG0438@2|Bacteria,2NNZH@2323|unclassified Bacteria	2|Bacteria	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
k59_611066_1	1392488.JHZY01000004_gene2177	4.89e-12	66.2	COG0841@1|root,COG0841@2|Bacteria,4NDZG@976|Bacteroidetes,1HX2H@117743|Flavobacteriia,2XJX2@283735|Leeuwenhoekiella	976|Bacteroidetes	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_666827_1	518766.Rmar_2310	2.6e-84	275.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,4NGU2@976|Bacteroidetes,1FIP7@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	M	Tricorn protease PDZ domain	-	-	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,PDZ,PDZ_2,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
k59_611078_1	445973.CLOBAR_02349	7.29e-17	86.7	COG3103@1|root,32GPZ@2|Bacteria	2|Bacteria	T	Bacterial SH3 domain	-	-	-	-	-	-	-	-	-	-	-	-	SH3_3
k59_220600_1	1126627.BAWE01000005_gene5331	2.91e-49	176.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,2TSCY@28211|Alphaproteobacteria,3JS0Q@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
k59_1556264_2	1206730.BAGA01000166_gene2241	1.37e-09	58.9	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,2GMN4@201174|Actinobacteria,4FX0N@85025|Nocardiaceae	201174|Actinobacteria	GT	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	-	-	2.7.9.1,2.7.9.2	ko:K01006,ko:K01007	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173,M00374	R00199,R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
k59_1556298_1	472759.Nhal_3356	1.43e-53	182.0	COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,1T1FT@1236|Gammaproteobacteria,1WXP0@135613|Chromatiales	135613|Chromatiales	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_220656_2	203124.Tery_0019	4.39e-40	147.0	COG0129@1|root,COG0129@2|Bacteria,1G0KD@1117|Cyanobacteria,1H8V6@1150|Oscillatoriales	1117|Cyanobacteria	EG	Belongs to the IlvD Edd family	ilvD	GO:0003674,GO:0003824,GO:0004160,GO:0016829,GO:0016835,GO:0016836	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
k59_667030_2	398580.Dshi_2247	7.92e-23	91.7	COG3415@1|root,COG3415@2|Bacteria,1NDFR@1224|Proteobacteria,2UGY4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_667030_3	398580.Dshi_3398	3.23e-90	268.0	COG3335@1|root,COG3335@2|Bacteria,1P76X@1224|Proteobacteria,2U16U@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
k59_667032_1	765420.OSCT_2859	4.16e-63	201.0	COG0572@1|root,COG0572@2|Bacteria,2G6D5@200795|Chloroflexi,376PV@32061|Chloroflexia	32061|Chloroflexia	F	PFAM phosphoribulokinase uridine kinase	udk	GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009224,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0043771,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046035,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.7.1.48	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PRK
k59_277464_1	391615.ABSJ01000032_gene724	9.15e-39	144.0	COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,1RN88@1236|Gammaproteobacteria,1J4RF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Belongs to the MurCDEF family	murC	GO:0000166,GO:0000270,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008763,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034645,GO:0035639,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0046872,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	iECP_1309.ECP_0093	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_834195_2	929562.Emtol_2227	1.06e-16	81.6	COG0673@1|root,COG0673@2|Bacteria,4NF4Q@976|Bacteroidetes,47M9C@768503|Cytophagia	976|Bacteroidetes	S	Oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
k59_1723695_1	1048834.TC41_3292	2.03e-51	179.0	COG0012@1|root,COG0012@2|Bacteria,1TPRK@1239|Firmicutes,4H9SQ@91061|Bacilli,277Y5@186823|Alicyclobacillaceae	91061|Bacilli	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
k59_445033_1	1283299.AUKG01000004_gene1001	1.1e-08	61.6	COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria,4CPP1@84995|Rubrobacteria	84995|Rubrobacteria	C	xanthine dehydrogenase, a b hammerhead	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_1278948_1	1828.JOKB01000029_gene3769	7.29e-22	101.0	COG2902@1|root,COG2902@2|Bacteria,2GK0C@201174|Actinobacteria,4FVGF@85025|Nocardiaceae	201174|Actinobacteria	E	glutamate dehydrogenase	-	-	1.4.1.2	ko:K15371	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	-	R00243	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	Bac_GDH
k59_1612506_2	926550.CLDAP_00740	9.01e-15	75.1	COG0248@1|root,COG0248@2|Bacteria,2G776@200795|Chloroflexi	200795|Chloroflexi	FP	PFAM Ppx GppA phosphatase	-	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	CHAD,HD,Ppx-GppA
k59_778617_1	1158292.JPOE01000005_gene685	4.94e-27	110.0	COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,2VH15@28216|Betaproteobacteria,1KJFN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
k59_667425_2	1445613.JALM01000035_gene488	2.61e-30	119.0	COG0167@1|root,COG0167@2|Bacteria,2GKC6@201174|Actinobacteria,4DXYI@85010|Pseudonocardiales	201174|Actinobacteria	F	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor	pyrD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.3.5.2,1.3.98.1	ko:K00226,ko:K00254	ko00240,ko01100,map00240,map01100	M00051	R01867,R01868	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
k59_111502_1	472759.Nhal_0438	4.08e-09	58.9	COG0688@1|root,COG0688@2|Bacteria,1MVT4@1224|Proteobacteria,1RN1U@1236|Gammaproteobacteria,1WWNF@135613|Chromatiales	135613|Chromatiales	I	Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily	psd	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
k59_111502_2	1121923.GPUN_2576	3.31e-20	89.7	COG2269@1|root,COG2269@2|Bacteria,1MU97@1224|Proteobacteria,1RMR9@1236|Gammaproteobacteria,4645R@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	COG2269 Truncated, possibly inactive, lysyl-tRNA synthetase (class II)	epmA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006430,GO:0006464,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016746,GO:0016755,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0052868,GO:0071704,GO:0071915,GO:0072580,GO:0072581,GO:0090304,GO:0140096,GO:1901360,GO:1901564,GO:1901566,GO:1901576	-	ko:K04568	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	tRNA-synt_2
k59_1001003_1	1144312.PMI09_02041	4.49e-55	181.0	COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,2VF1S@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
k59_945399_1	932678.THERU_07815	3.15e-20	88.6	COG0115@1|root,COG0115@2|Bacteria,2G3W3@200783|Aquificae	200783|Aquificae	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
k59_1167788_2	1125701.HMPREF1221_00122	0.000185	48.9	COG0801@1|root,COG0801@2|Bacteria,2J8EN@203691|Spirochaetes	203691|Spirochaetes	H	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	-	2.7.6.3	ko:K00950	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HPPK
k59_278263_1	1286106.MPL1_03538	7.07e-54	175.0	COG2210@1|root,COG2210@2|Bacteria,1RDUG@1224|Proteobacteria,1RRM7@1236|Gammaproteobacteria,4612C@72273|Thiotrichales	72273|Thiotrichales	S	DsrE/DsrF/DrsH-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2
k59_278263_2	1034347.CAHJ01000054_gene127	3e-22	88.6	COG0425@1|root,COG0425@2|Bacteria,1VEEC@1239|Firmicutes,4HNQT@91061|Bacilli,1ZI1V@1386|Bacillus	91061|Bacilli	O	Belongs to the sulfur carrier protein TusA family	yrkI	GO:0008150,GO:0009987,GO:0019725,GO:0042592,GO:0048878,GO:0055082,GO:0065007,GO:0065008	-	-	-	-	-	-	-	-	-	-	TusA
k59_222681_1	713587.THITH_04495	5.8e-28	117.0	COG0747@1|root,COG3889@1|root,COG0747@2|Bacteria,COG3889@2|Bacteria,1R6EI@1224|Proteobacteria	1224|Proteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_55899_1	1189612.A33Q_1129	2.38e-67	226.0	COG1506@1|root,COG1506@2|Bacteria,4NE2Q@976|Bacteroidetes,47N56@768503|Cytophagia	976|Bacteroidetes	E	Dipeptidyl peptidase IV (DPP IV) N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	DPPIV_N,Peptidase_S9
k59_723060_1	2002.JOEQ01000024_gene215	9.68e-56	189.0	COG0174@1|root,COG0174@2|Bacteria,2GJ83@201174|Actinobacteria,4ENPD@85012|Streptosporangiales	201174|Actinobacteria	E	Glutamine synthetase N-terminal domain	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N_2
k59_1167795_1	1121447.JONL01000002_gene1832	2.19e-16	75.9	COG3030@1|root,COG3030@2|Bacteria,1MZJJ@1224|Proteobacteria,42VMT@68525|delta/epsilon subdivisions,2WPFB@28221|Deltaproteobacteria,2MCEP@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM FxsA cytoplasmic membrane protein	fsxA	-	-	ko:K07113	-	-	-	-	ko00000	-	-	-	FxsA
k59_1167795_2	1415778.JQMM01000001_gene772	4.89e-24	100.0	COG0614@1|root,COG0614@2|Bacteria,1RBT1@1224|Proteobacteria,1S21C@1236|Gammaproteobacteria,1J8AI@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Periplasmic binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_2
k59_1668145_1	1202962.KB907164_gene3953	2.1e-24	104.0	COG3766@1|root,COG3766@2|Bacteria,1Q8XV@1224|Proteobacteria,1T1F5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of Unknown Function (DUF350)	-	-	-	-	-	-	-	-	-	-	-	-	DUF350
k59_337_1	566461.SSFG_06851	2.57e-36	134.0	COG1011@1|root,COG1011@2|Bacteria,2IBB1@201174|Actinobacteria	201174|Actinobacteria	S	Haloacid dehalogenase-like hydrolase	-	-	3.8.1.2	ko:K01560	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	HAD_2
k59_337_2	96561.Dole_0596	3.57e-31	120.0	COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,42MQT@68525|delta/epsilon subdivisions,2WIP1@28221|Deltaproteobacteria,2MJ4R@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Peptidoglycan polymerase that is essential for cell wall elongation	mrdB	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
k59_500663_1	1122214.AQWH01000031_gene2983	6.36e-66	218.0	COG2072@1|root,COG2072@2|Bacteria,1MUKW@1224|Proteobacteria,2TQVE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	K_oxygenase,Pyr_redox_3
k59_167101_1	671143.DAMO_1272	1.27e-140	410.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	bchE	-	1.21.98.3	ko:K04034	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06268,R06269,R06270	RC00741,RC01491,RC01492	ko00000,ko00001,ko01000	-	-	-	B12-binding,Radical_SAM
k59_1612548_1	378806.STAUR_3879	1.08e-39	150.0	COG0507@1|root,COG0507@2|Bacteria,1MW43@1224|Proteobacteria,42M8J@68525|delta/epsilon subdivisions,2WJD6@28221|Deltaproteobacteria,2YTW8@29|Myxococcales	28221|Deltaproteobacteria	L	DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity	recD2	-	3.1.11.5	ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_30,HHH_4,HHH_5,UvrD_C_2
k59_1334591_1	37682.EMT12449	2.89e-71	241.0	COG0046@1|root,KOG1907@2759|Eukaryota,37IK9@33090|Viridiplantae,3GFB1@35493|Streptophyta,3KPKM@4447|Liliopsida,3IATH@38820|Poales	35493|Streptophyta	F	CobB/CobQ-like glutamine amidotransferase domain	-	GO:0000166,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0007275,GO:0008144,GO:0008150,GO:0009507,GO:0009532,GO:0009536,GO:0009555,GO:0009570,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0030554,GO:0032501,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0048229,GO:0048856,GO:0055046,GO:0097159,GO:0097367,GO:1901265,GO:1901363	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS_C,GATase_5
k59_1112257_1	713587.THITH_05440	1.17e-71	230.0	COG1262@1|root,COG1262@2|Bacteria,1MUNC@1224|Proteobacteria,1RQI4@1236|Gammaproteobacteria,1WZEX@135613|Chromatiales	135613|Chromatiales	H	DinB superfamily	-	-	1.14.99.50	ko:K18912	ko00340,map00340	-	R11013	RC03323,RC03324	ko00000,ko00001,ko01000	-	-	-	DinB_2,FGE-sulfatase
k59_1501376_1	1082933.MEA186_19207	7.37e-144	425.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2TR00@28211|Alphaproteobacteria,43P31@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	J	Amidase	-	-	3.5.1.54	ko:K01457	ko00220,ko00791,ko01100,ko01120,map00220,map00791,map01100,map01120	-	R00005	RC02756	ko00000,ko00001,ko01000	-	-	-	Amidase
k59_1501376_2	1123229.AUBC01000017_gene3852	8.4e-08	52.4	COG2230@1|root,COG2890@1|root,COG2230@2|Bacteria,COG2890@2|Bacteria,1QUR4@1224|Proteobacteria	1224|Proteobacteria	M	PFAM Methyltransferase type 11	-	-	2.1.1.157,2.1.1.95	ko:K05928,ko:K18897	ko00130,ko00260,ko01100,ko01110,map00130,map00260,map01100,map01110	M00112	R07236,R07504,R10061,R10491,R10492	RC00003,RC01662,RC03040	ko00000,ko00001,ko00002,ko01000	-	-	-	CMAS,Methyltransf_11
k59_1112263_2	985665.HPL003_09750	2.23e-14	77.8	COG2217@1|root,COG2217@2|Bacteria,1TP5S@1239|Firmicutes,4HAI0@91061|Bacilli,26TJQ@186822|Paenibacillaceae	91061|Bacilli	P	ATPase P	copA	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0042802,GO:0044464,GO:0071944	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
k59_1445826_1	1469613.JT55_03730	7.88e-60	198.0	COG4148@1|root,COG4148@2|Bacteria,1MU8K@1224|Proteobacteria,2TR1Z@28211|Alphaproteobacteria,3FCP9@34008|Rhodovulum	28211|Alphaproteobacteria	P	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system	modC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.3.29	ko:K02017	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran,TOBE
k59_1501392_1	316056.RPC_2269	1.24e-101	308.0	COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,2TRHX@28211|Alphaproteobacteria,3JQRE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
k59_778682_1	269796.Rru_A2700	4.27e-54	173.0	COG0250@1|root,COG0250@2|Bacteria,1MU14@1224|Proteobacteria,2TRID@28211|Alphaproteobacteria,2JQKK@204441|Rhodospirillales	204441|Rhodospirillales	K	Participates in transcription elongation, termination and antitermination	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
k59_778682_2	1248917.ANFX01000014_gene1303	2.49e-71	217.0	COG0080@1|root,COG0080@2|Bacteria,1RA2M@1224|Proteobacteria,2U760@28211|Alphaproteobacteria,2K3Z9@204457|Sphingomonadales	204457|Sphingomonadales	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	-	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
k59_222733_2	714943.Mucpa_2581	3.47e-07	51.2	COG4319@1|root,COG4319@2|Bacteria,4NS9D@976|Bacteroidetes,1ITI3@117747|Sphingobacteriia	976|Bacteroidetes	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
k59_333905_1	99598.Cal7507_3130	9.57e-119	364.0	COG3385@1|root,COG3385@2|Bacteria,1GBUK@1117|Cyanobacteria,1HK07@1161|Nostocales	1117|Cyanobacteria	L	SPTR Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,Dimer_Tnp_Tn5
k59_1223467_1	1443665.JACA01000053_gene3261	9.81e-92	296.0	COG4447@1|root,COG4447@2|Bacteria,4NESU@976|Bacteroidetes,1HXIG@117743|Flavobacteriia,2YIFW@290174|Aquimarina	976|Bacteroidetes	S	BNR Asp-box repeat	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
k59_278324_2	743836.AYNA01000044_gene1150	8.97e-26	108.0	COG0714@1|root,COG0714@2|Bacteria,1MUCP@1224|Proteobacteria,2U0P9@28211|Alphaproteobacteria,36Z80@31993|Methylocystaceae	28211|Alphaproteobacteria	S	ATPase family associated with various cellular activities (AAA)	mxaR	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	-	-	-	-	-	-	-	-	-	AAA_3
k59_945472_1	1267535.KB906767_gene965	5.32e-64	209.0	COG4975@1|root,COG4975@2|Bacteria,3Y6YG@57723|Acidobacteria	57723|Acidobacteria	G	Ureide permease	-	-	-	ko:K05340	-	-	-	-	ko00000,ko02000	2.A.7.5	-	-	Ureide_permease
k59_385_1	469383.Cwoe_1155	1.81e-17	89.0	COG1034@1|root,COG1153@1|root,COG1034@2|Bacteria,COG1153@2|Bacteria,2GJGX@201174|Actinobacteria,4CR3F@84995|Rubrobacteria	84995|Rubrobacteria	C	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region	-	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_1557020_1	316274.Haur_1525	5.78e-87	267.0	COG2213@1|root,COG2213@2|Bacteria	2|Bacteria	G	protein-N(PI)-phosphohistidine-mannitol phosphotransferase system transmembrane transporter activity	mtlA	-	2.7.1.197	ko:K02798,ko:K02799,ko:K02800	ko00051,ko02060,map00051,map02060	M00274	R02704	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1.12,4.A.2.1.2,4.A.2.1.24,4.A.2.1.5	-	-	PTS_EIIA_2,PTS_EIIC,PTS_IIB
k59_393_1	1301098.PKB_2431	2.31e-11	67.4	COG2188@1|root,COG3746@1|root,COG2188@2|Bacteria,COG3746@2|Bacteria,1MV8P@1224|Proteobacteria,1T5CM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Putative porin	-	-	-	-	-	-	-	-	-	-	-	-	Porin_5
k59_1167869_2	1449058.JQKT01000007_gene1127	2.02e-62	200.0	COG0179@1|root,COG0179@2|Bacteria,2GN2G@201174|Actinobacteria,4FKZX@85023|Microbacteriaceae	201174|Actinobacteria	Q	Domain of unknown function (DUF2437)	fahA	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
k59_556310_1	234267.Acid_7208	1.62e-13	75.5	COG0577@1|root,COG0577@2|Bacteria,3Y3KJ@57723|Acidobacteria	57723|Acidobacteria	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_556324_1	981383.AEWH01000063_gene1955	0.000581	47.8	COG0842@1|root,COG0842@2|Bacteria,1V0J8@1239|Firmicutes,4HEBH@91061|Bacilli	91061|Bacilli	V	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
k59_889933_1	269796.Rru_A0683	5.95e-84	261.0	COG3200@1|root,COG3200@2|Bacteria,1MUWF@1224|Proteobacteria,2TR0E@28211|Alphaproteobacteria,2JPFU@204441|Rhodospirillales	204441|Rhodospirillales	E	phospho-2-dehydro-3-deoxyheptonate aldolase	aroF	-	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_2
k59_56007_1	1038867.AXAY01000009_gene5710	1.32e-54	188.0	COG3387@1|root,COG3387@2|Bacteria,1MV08@1224|Proteobacteria,2TRMQ@28211|Alphaproteobacteria,3JRQ3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Glycosyl hydrolases family 15	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_15
k59_278370_1	439235.Dalk_4440	8.56e-53	181.0	COG0265@1|root,COG0265@2|Bacteria,1RBDX@1224|Proteobacteria	1224|Proteobacteria	O	COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_1,PDZ_2,Trypsin_2
k59_1612629_1	925409.KI911562_gene2762	4.1e-39	141.0	COG0491@1|root,COG0491@2|Bacteria,4NH8C@976|Bacteroidetes,1IVMC@117747|Sphingobacteriia	976|Bacteroidetes	S	Metallo-beta-lactamase superfamily	-	-	3.5.2.6	ko:K17837	ko01501,map01501	-	R06363	RC01499	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
k59_500756_1	1229485.AMYV01000002_gene3537	1.57e-71	229.0	COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,1RMF6@1236|Gammaproteobacteria,1J51D@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	GO:0003674,GO:0003824,GO:0003861,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009316,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iEcE24377_1341.EcE24377A_0075,iPC815.YPO0531	Aconitase
k59_1557059_1	1235803.C825_03495	1.25e-28	122.0	COG1629@1|root,COG4771@2|Bacteria,4P1Z5@976|Bacteroidetes,2FWS8@200643|Bacteroidia,22WSE@171551|Porphyromonadaceae	976|Bacteroidetes	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
k59_222784_1	1266925.JHVX01000001_gene2549	1.68e-47	159.0	COG1814@1|root,COG1814@2|Bacteria,1MUZE@1224|Proteobacteria,2VJ27@28216|Betaproteobacteria,3723D@32003|Nitrosomonadales	28216|Betaproteobacteria	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
k59_834341_1	562970.Btus_1278	7.7e-96	295.0	COG1960@1|root,COG1960@2|Bacteria,1TR1Y@1239|Firmicutes,4HC1N@91061|Bacilli,279IR@186823|Alicyclobacillaceae	91061|Bacilli	C	Acyl-CoA dehydrogenase, N-terminal domain	-	-	-	ko:K06446	ko00930,ko01100,ko01120,map00930,map01100,map01120	-	R06943	RC00052	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_222786_1	760192.Halhy_2510	7.66e-100	313.0	COG1913@1|root,COG1913@2|Bacteria,4PMAZ@976|Bacteroidetes,1IRBZ@117747|Sphingobacteriia	976|Bacteroidetes	S	Domain of unknown function (DUF5117)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4953,DUF5117,DUF5118
k59_1001144_1	926569.ANT_17720	5.91e-74	235.0	COG0124@1|root,COG0124@2|Bacteria,2G64E@200795|Chloroflexi	200795|Chloroflexi	J	PFAM tRNA synthetase class II (G H P and S)	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
k59_1557075_1	760192.Halhy_1321	1.11e-84	269.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,4NHS5@976|Bacteroidetes,1IVS2@117747|Sphingobacteriia	976|Bacteroidetes	EU	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
k59_1279107_1	1122619.KB892322_gene8	1.07e-87	280.0	COG4372@1|root,COG4372@2|Bacteria,1MUCX@1224|Proteobacteria,2WGN9@28216|Betaproteobacteria,3T3JA@506|Alcaligenaceae	28216|Betaproteobacteria	S	Transposase IS66 family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
k59_1279110_1	1166018.FAES_2224	1.31e-09	63.9	COG0745@1|root,COG0745@2|Bacteria,4NN7I@976|Bacteroidetes,47PD4@768503|Cytophagia	976|Bacteroidetes	T	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07665	ko02020,map02020	M00452,M00745	-	-	ko00000,ko00001,ko00002,ko01504,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_556378_1	105425.BBPL01000022_gene981	4.1e-10	63.2	COG0500@1|root,COG0500@2|Bacteria,2I2Y4@201174|Actinobacteria,2NGQU@228398|Streptacidiphilus	201174|Actinobacteria	Q	O-methyltransferase	-	-	2.1.1.303	ko:K20421	ko01059,ko01130,map01059,map01130	M00830	R10963	RC00003,RC00392	ko00000,ko00001,ko00002,ko01000	-	-	-	Dimerisation2,Methyltransf_2
k59_945558_1	402881.Plav_2708	8.8e-40	152.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria,1JMZF@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_1167949_1	419665.Maeo_0157	9.64e-40	147.0	COG1641@1|root,arCOG02701@2157|Archaea,2XV3G@28890|Euryarchaeota,23QR0@183939|Methanococci	183939|Methanococci	S	Belongs to the LarC family	-	-	4.99.1.12	ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	DUF111
k59_1668286_1	1123276.KB893246_gene854	8.83e-103	317.0	COG3385@1|root,COG3385@2|Bacteria,4P02Y@976|Bacteroidetes,47TUA@768503|Cytophagia	976|Bacteroidetes	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_1445954_1	331869.BAL199_03144	3.94e-28	112.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria,4BPVK@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	G	C4-dicarboxylate anaerobic carrier	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_278430_1	357808.RoseRS_2842	2.56e-22	100.0	COG2199@1|root,COG2203@1|root,COG2199@2|Bacteria,COG2203@2|Bacteria,2G8CK@200795|Chloroflexi,3776C@32061|Chloroflexia	32061|Chloroflexia	T	PFAM GGDEF domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF
k59_222831_1	861299.J421_3048	2.1e-106	342.0	COG0060@1|root,COG0060@2|Bacteria,1ZSKS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
k59_945579_1	1205680.CAKO01000030_gene4829	1.04e-14	70.1	COG0782@1|root,COG0782@2|Bacteria,1RCXW@1224|Proteobacteria,2U5JU@28211|Alphaproteobacteria,2JS6I@204441|Rhodospirillales	204441|Rhodospirillales	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
k59_945579_2	414684.RC1_2014	1.12e-42	156.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,2TQZU@28211|Alphaproteobacteria,2JQ9C@204441|Rhodospirillales	204441|Rhodospirillales	F	Belongs to the CarB family	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_778807_1	671143.DAMO_1836	1.3e-91	282.0	COG0860@1|root,COG0860@2|Bacteria,2NPCZ@2323|unclassified Bacteria	2|Bacteria	M	Ami_3	amiA	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3
k59_412382_1	68194.JNXR01000003_gene3088	2.07e-14	74.3	COG1853@1|root,COG1853@2|Bacteria,2GYGX@201174|Actinobacteria	201174|Actinobacteria	S	PFAM flavin reductase domain protein, FMN-binding	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
k59_1135665_1	309807.SRU_2383	3.2e-37	144.0	COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria,4NERT@976|Bacteroidetes,1FJ3R@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	MU	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	BSP,Bac_surface_Ag,PD40
k59_1024820_1	861299.J421_2337	5.63e-81	254.0	COG0624@1|root,COG0624@2|Bacteria,1ZT2K@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
k59_301307_1	1121448.DGI_3251	6.05e-15	80.1	COG0835@1|root,COG0835@2|Bacteria,1RAH1@1224|Proteobacteria,42S69@68525|delta/epsilon subdivisions,2X5TT@28221|Deltaproteobacteria,2MGVV@213115|Desulfovibrionales	28221|Deltaproteobacteria	NT	Two component signalling adaptor domain	-	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
k59_801761_2	926569.ANT_08620	1.57e-47	160.0	COG1381@1|root,COG1381@2|Bacteria,2G6N7@200795|Chloroflexi	200795|Chloroflexi	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
k59_469022_1	1089552.KI911559_gene1021	4.74e-55	184.0	COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,2TR0T@28211|Alphaproteobacteria,2JPBV@204441|Rhodospirillales	204441|Rhodospirillales	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
k59_1691319_2	94624.Bpet2004	6.13e-29	105.0	COG0228@1|root,COG0228@2|Bacteria,1MZCT@1224|Proteobacteria,2VTYP@28216|Betaproteobacteria,3T4JM@506|Alcaligenaceae	28216|Betaproteobacteria	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	-	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
k59_1301994_1	633148.Tagg_1265	2.92e-11	64.3	COG1013@1|root,arCOG01599@2157|Archaea,2XPQG@28889|Crenarchaeota	28889|Crenarchaeota	C	TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, beta subunit	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
k59_1301994_2	1267534.KB906759_gene1728	7.13e-42	152.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,3Y3NX@57723|Acidobacteria,2JKIA@204432|Acidobacteriia	2|Bacteria	C	Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg	porA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iLJ478.TM1164	PFOR_II,POR,POR_N,Transketolase_C
k59_1468999_1	439497.RR11_1366	2.09e-22	98.2	COG2968@1|root,COG2968@2|Bacteria,1RH7T@1224|Proteobacteria,2U981@28211|Alphaproteobacteria,4NBG8@97050|Ruegeria	28211|Alphaproteobacteria	S	Outer membrane protein, 28Kda	omp28	GO:0005575,GO:0005623,GO:0042597,GO:0044464	-	ko:K09807	-	-	-	-	ko00000	-	-	-	SIMPL
k59_412409_1	709797.CSIRO_1662	1.52e-23	104.0	COG1167@1|root,COG1167@2|Bacteria,1MV6F@1224|Proteobacteria,2TR7I@28211|Alphaproteobacteria,3JRS7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EK	Alanine-glyoxylate amino-transferase	MA20_07365	-	-	ko:K00375,ko:K05825	ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210	-	R01939	RC00006	ko00000,ko00001,ko01000,ko03000	-	-	-	Aminotran_1_2,GntR
k59_1079399_1	877455.Metbo_0564	1.91e-29	119.0	COG0075@1|root,arCOG00082@2157|Archaea,2XTWU@28890|Euryarchaeota,23NPQ@183925|Methanobacteria	183925|Methanobacteria	E	Aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
k59_469062_1	479434.Sthe_3201	3.54e-05	50.4	COG4961@1|root,COG4961@2|Bacteria	2|Bacteria	U	PFAM TadE family protein	-	-	-	-	-	-	-	-	-	-	-	-	Tad,Tad_C
k59_78626_1	671143.DAMO_1011	2.11e-128	386.0	COG1222@1|root,COG1222@2|Bacteria	2|Bacteria	O	protein catabolic process	-	-	-	ko:K13525,ko:K13527	ko03050,ko04141,ko05134,map03050,map04141,map05134	M00342,M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko03051,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N
k59_356301_1	187272.Mlg_0087	8.67e-73	234.0	COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,1RMY6@1236|Gammaproteobacteria,1WWPJ@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA	ilvA	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_dehydrat_C
k59_746227_1	1079986.JH164837_gene5883	7.51e-40	136.0	COG2164@1|root,COG2164@2|Bacteria,2II7B@201174|Actinobacteria	201174|Actinobacteria	S	Cyclophilin-like	-	-	-	ko:K09143	-	-	-	-	ko00000	-	-	-	Cyclophil_like
k59_1302035_2	1415166.NONO_c24960	2.78e-30	119.0	COG0237@1|root,COG0237@2|Bacteria,2GN96@201174|Actinobacteria,4FUXF@85025|Nocardiaceae	201174|Actinobacteria	H	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	GO:0000166,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0004140,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018130,GO:0019103,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032551,GO:0032552,GO:0032553,GO:0032554,GO:0032557,GO:0032558,GO:0032564,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE,GrpB
k59_1634422_1	158189.SpiBuddy_2581	5.96e-08	59.3	COG0454@1|root,COG2203@1|root,COG4191@1|root,COG0456@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,2J9V6@203691|Spirochaetes	203691|Spirochaetes	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,HATPase_c,HisKA,PAS,PAS_9,Response_reg
k59_356317_2	1245475.ANAE01000127_gene606	3.39e-09	60.5	COG0235@1|root,COG0235@2|Bacteria,2IJ2Q@201174|Actinobacteria,4EM7I@85012|Streptosporangiales	201174|Actinobacteria	G	Class II Aldolase and Adducin N-terminal domain	-	-	-	ko:K10622	ko00362,ko00622,ko01120,ko01220,map00362,map00622,map01120,map01220	M00539	R02763,R05377	RC00779	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase_II
k59_469091_2	1088721.NSU_3630	8.29e-40	139.0	COG0684@1|root,COG0684@2|Bacteria,1MW9P@1224|Proteobacteria,2TTGT@28211|Alphaproteobacteria,2K1KB@204457|Sphingomonadales	204457|Sphingomonadales	H	Aldolase/RraA	-	-	4.1.3.17	ko:K10218	ko00362,ko00660,ko01120,map00362,map00660,map01120	-	R00008,R00350	RC00067,RC00502,RC01205	ko00000,ko00001,ko01000	-	-	-	RraA-like
k59_914085_1	1242864.D187_008374	2.23e-69	220.0	COG0345@1|root,COG0345@2|Bacteria,1R5J1@1224|Proteobacteria,42P7F@68525|delta/epsilon subdivisions,2WJW9@28221|Deltaproteobacteria,2YTWD@29|Myxococcales	28221|Deltaproteobacteria	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_0899	F420_oxidored,P5CR_dimer
k59_1691426_1	1121933.AUHH01000017_gene255	2.73e-12	71.6	COG4585@1|root,COG4585@2|Bacteria,2GKV2@201174|Actinobacteria,4DT6S@85009|Propionibacteriales	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
k59_412452_1	1415630.U771_25800	9.36e-16	76.6	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_412452_2	301.JNHE01000001_gene509	4.41e-22	97.1	COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,1RQJ9@1236|Gammaproteobacteria,1YFHW@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	acrA	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
k59_1524359_1	1445613.JALM01000027_gene6466	5.2e-12	60.5	COG0361@1|root,COG0361@2|Bacteria,2IQ4B@201174|Actinobacteria,4E5BJ@85010|Pseudonocardiales	201174|Actinobacteria	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071944	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
k59_1524359_2	1122994.AUFR01000002_gene1257	4.66e-30	114.0	COG0024@1|root,COG0024@2|Bacteria,2GKKB@201174|Actinobacteria,4DNQ9@85009|Propionibacteriales	201174|Actinobacteria	J	Methionine aminopeptidase	mapA	GO:0000096,GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005506,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006464,GO:0006508,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009066,GO:0009987,GO:0010467,GO:0016020,GO:0016151,GO:0016485,GO:0016787,GO:0019538,GO:0019752,GO:0030145,GO:0035551,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0044464,GO:0046872,GO:0046914,GO:0050897,GO:0051604,GO:0070006,GO:0070011,GO:0070084,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901605	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
k59_1024962_2	926569.ANT_23450	1.55e-74	235.0	COG0849@1|root,COG0849@2|Bacteria,2G5V5@200795|Chloroflexi	200795|Chloroflexi	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
k59_968948_1	861299.J421_4088	1.83e-60	211.0	COG3408@1|root,COG3408@2|Bacteria	2|Bacteria	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Bac_rhamnosid6H,GDE_C,SLH
k59_469159_1	177439.DP2715	3.04e-20	96.3	COG2199@1|root,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,42S7S@68525|delta/epsilon subdivisions,2WNFR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS,PAS_4
k59_1079447_1	1177154.Y5S_00553	6.41e-49	169.0	COG0842@1|root,COG0842@2|Bacteria,1MUIA@1224|Proteobacteria,1SKHE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	ABC-2 family transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_3
k59_412486_1	572479.Hprae_0841	6.5e-27	113.0	COG1459@1|root,COG1459@2|Bacteria,1TQRZ@1239|Firmicutes,249FV@186801|Clostridia,3WAFC@53433|Halanaerobiales	186801|Clostridia	U	PFAM Bacterial type II secretion system protein F domain	-	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
k59_469166_1	1123320.KB889707_gene7966	5.37e-74	235.0	COG0612@1|root,COG0612@2|Bacteria,2GJZ3@201174|Actinobacteria	201174|Actinobacteria	S	Belongs to the peptidase M16 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_690993_1	1122604.JONR01000014_gene237	2.89e-29	122.0	COG5616@1|root,COG5616@2|Bacteria,1NSKC@1224|Proteobacteria,1S876@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1580017_1	83406.HDN1F_17130	2.99e-22	92.0	COG2402@1|root,COG2402@2|Bacteria,1NCFK@1224|Proteobacteria,1SRQ2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	PIN domain	-	-	-	ko:K07065	-	-	-	-	ko00000	-	-	-	PIN
k59_1580018_1	105559.Nwat_0572	3.56e-64	217.0	COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,1RSQQ@1236|Gammaproteobacteria,1WWA4@135613|Chromatiales	135613|Chromatiales	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	Thioredox_DsbH
k59_1302159_1	926550.CLDAP_26600	1.15e-44	165.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,2G5VK@200795|Chloroflexi	200795|Chloroflexi	E	glutamate synthase, alpha subunit domain protein	gltB	-	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_9,GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_691003_1	671143.DAMO_0975	1.96e-100	309.0	COG0465@1|root,COG0465@2|Bacteria,2NP22@2323|unclassified Bacteria	2|Bacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	-	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_578634_1	196162.Noca_3037	3.24e-43	142.0	COG2920@1|root,COG2920@2|Bacteria,2IQB2@201174|Actinobacteria,4DVG7@85009|Propionibacteriales	201174|Actinobacteria	P	DsrC like protein	-	-	-	ko:K11179	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DsrC
k59_578634_2	479431.Namu_0352	1.58e-38	132.0	COG2210@1|root,COG2210@2|Bacteria,2IFXH@201174|Actinobacteria,4EWZZ@85013|Frankiales	201174|Actinobacteria	S	DsrE/DsrF/DrsH-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2
k59_914176_1	365046.Rta_14960	3.79e-52	181.0	28HC9@1|root,2Z7P5@2|Bacteria,1R4BH@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_968999_1	1463920.JOGB01000021_gene2051	2.92e-05	45.8	COG1968@1|root,COG1968@2|Bacteria,2GJVG@201174|Actinobacteria	201174|Actinobacteria	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
k59_968999_2	1158146.KB907123_gene750	4.87e-06	52.4	COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,1RNVQ@1236|Gammaproteobacteria,1WVX7@135613|Chromatiales	135613|Chromatiales	P	PFAM TrkA-N domain	trkA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
k59_969000_1	926554.KI912635_gene3020	6.45e-59	203.0	COG0495@1|root,COG0495@2|Bacteria,1WIX9@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,Leucyl-specific,tRNA-synt_1,tRNA-synt_1_2
k59_1413221_1	493475.GARC_4254	1.22e-15	80.1	COG0741@1|root,COG0741@2|Bacteria,1MZ4X@1224|Proteobacteria,1S8R3@1236|Gammaproteobacteria,46768@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4124,SLT,Sel1
k59_23483_1	935567.JAES01000048_gene610	9.61e-25	102.0	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,1RMSS@1236|Gammaproteobacteria,1X3FD@135614|Xanthomonadales	135614|Xanthomonadales	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
k59_78729_1	349163.Acry_1266	1.03e-31	124.0	COG2828@1|root,COG2828@2|Bacteria,1MXVV@1224|Proteobacteria,2TQMC@28211|Alphaproteobacteria,2JVRD@204441|Rhodospirillales	204441|Rhodospirillales	S	PrpF protein	-	-	-	-	-	-	-	-	-	-	-	-	PrpF
k59_1190958_1	420324.KI911965_gene1283	2.98e-15	79.0	COG0500@1|root,COG2226@2|Bacteria,1P9C1@1224|Proteobacteria,2U359@28211|Alphaproteobacteria,1JZ1F@119045|Methylobacteriaceae	28211|Alphaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_633975_1	861299.J421_0281	1.65e-30	125.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_78744_1	314285.KT71_09797	4.93e-76	245.0	COG2192@1|root,COG2192@2|Bacteria,1MWBA@1224|Proteobacteria,1RNN4@1236|Gammaproteobacteria,1J5H3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	Carbamoyltransferase C-terminus	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
k59_633976_1	391038.Bphy_7355	3.04e-28	110.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2VQF1@28216|Betaproteobacteria,1K4GQ@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Integrase core domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve
k59_1691603_1	331869.BAL199_24039	2.42e-79	247.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Belongs to the thiolase family	MA20_18575	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_1079522_1	425104.Ssed_0448	1.21e-100	313.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MUJ3@1224|Proteobacteria,1RRN4@1236|Gammaproteobacteria,2QB94@267890|Shewanellaceae	1236|Gammaproteobacteria	EU	Acetyl xylan esterase (AXE1)	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9,Peptidase_S9_N
k59_1469100_1	640081.Dsui_3097	7.55e-59	197.0	COG0350@1|root,COG2169@1|root,COG0350@2|Bacteria,COG2169@2|Bacteria,1N2YQ@1224|Proteobacteria,2VIAK@28216|Betaproteobacteria,2KUGK@206389|Rhodocyclales	206389|Rhodocyclales	L	6-O-methylguanine DNA methyltransferase, DNA binding domain	-	-	2.1.1.63	ko:K00567,ko:K10778	-	-	-	-	ko00000,ko01000,ko03000,ko03400	-	-	-	Ada_Zn_binding,DNA_binding_1,HTH_18
k59_80598_1	1536769.P40081_28605	5.33e-73	229.0	COG0175@1|root,COG0175@2|Bacteria,1TZYA@1239|Firmicutes,4I97T@91061|Bacilli,27157@186822|Paenibacillaceae	91061|Bacilli	EH	Phosphoadenosine phosphosulfate reductase family	-	-	-	-	-	-	-	-	-	-	-	-	PAPS_reduct
k59_916129_1	1437882.AZRU01000033_gene511	3.63e-15	75.1	COG2128@1|root,COG2128@2|Bacteria,1RD2I@1224|Proteobacteria	1224|Proteobacteria	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
k59_1581849_1	316067.Geob_1667	3.41e-33	127.0	COG0585@1|root,COG0585@2|Bacteria,1MXHD@1224|Proteobacteria,42P4E@68525|delta/epsilon subdivisions,2WN09@28221|Deltaproteobacteria,43SVP@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs	truD	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0016070,GO:0016853,GO:0016866,GO:0034641,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	5.4.99.27	ko:K06176	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruD
k59_1304074_1	929713.NIASO_07510	4.46e-26	101.0	2DNS7@1|root,32YWC@2|Bacteria,4NSJ6@976|Bacteroidetes,1ITMS@117747|Sphingobacteriia	976|Bacteroidetes	J	ribosomal protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
k59_1471060_1	1048339.KB913029_gene586	3.63e-05	48.5	COG0582@1|root,COG1725@1|root,COG0582@2|Bacteria,COG1725@2|Bacteria,2I9QS@201174|Actinobacteria,4ETT7@85013|Frankiales	201174|Actinobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_3,Phage_int_SAM_5,Phage_integrase
k59_1471060_2	518766.Rmar_1254	1.96e-07	52.4	COG0322@1|root,COG0322@2|Bacteria,4NE61@976|Bacteroidetes,1FJ3X@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
k59_1081355_1	1082931.KKY_3906	5.67e-06	45.1	COG1476@1|root,COG1476@2|Bacteria,1N7BB@1224|Proteobacteria	1224|Proteobacteria	K	TRANSCRIPTIONal	-	-	-	ko:K07729	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
k59_525538_1	1313172.YM304_09450	6.34e-50	175.0	COG0488@1|root,COG0488@2|Bacteria,2GK9S@201174|Actinobacteria	201174|Actinobacteria	S	ABC transporter	yjjK	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
k59_80613_1	795666.MW7_3399	2.27e-08	54.7	COG1951@1|root,COG1951@2|Bacteria,1MW8J@1224|Proteobacteria,2VKI4@28216|Betaproteobacteria,1KHN1@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Fumarate hydratase (Fumerase)	ttdA	-	4.2.1.2,4.2.1.32	ko:K01677,ko:K03779	ko00020,ko00620,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00630,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00339,R01082	RC00443,RC01382	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase
k59_80613_2	713586.KB900536_gene708	1.08e-27	104.0	COG2009@1|root,COG2009@2|Bacteria,1N8VA@1224|Proteobacteria	1224|Proteobacteria	C	succinate dehydrogenase	-	-	-	ko:K00247	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
k59_135830_1	1131269.AQVV01000001_gene1346	5.55e-51	173.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
k59_1693629_1	1205680.CAKO01000038_gene2063	3.13e-92	286.0	COG2072@1|root,COG2072@2|Bacteria,1MUQH@1224|Proteobacteria,2TRG4@28211|Alphaproteobacteria,2JRI5@204441|Rhodospirillales	28211|Alphaproteobacteria	P	Flavin-binding monooxygenase-like	-	-	1.14.13.22	ko:K03379	ko00930,ko01120,ko01220,map00930,map01120,map01220	-	R02231,R06622	RC00662,RC01550	ko00000,ko00001,ko01000	-	-	-	FMO-like,Pyr_redox_3
k59_1596039_2	443598.AUFA01000008_gene4092	5.84e-21	87.4	COG0193@1|root,COG0193@2|Bacteria,1MX1P@1224|Proteobacteria,2TT6Q@28211|Alphaproteobacteria,3JSPW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
k59_985555_1	1469613.JT55_04700	9.64e-47	164.0	COG2223@1|root,COG2223@2|Bacteria,1QWUY@1224|Proteobacteria,2TX66@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	COG0477 Permeases of the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_260052_1	546414.Deide_19570	6.82e-49	163.0	COG0740@1|root,COG0740@2|Bacteria,1WI6Y@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	OU	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
k59_1485026_1	1379270.AUXF01000003_gene3841	2.9e-09	57.0	COG2204@1|root,COG2204@2|Bacteria,1ZUM4@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1485026_2	861299.J421_2630	7.46e-25	95.9	COG0355@1|root,COG0355@2|Bacteria,1ZU1K@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	-	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE_N
k59_260057_1	105422.BBPM01000004_gene5520	3.81e-92	281.0	COG0468@1|root,COG0468@2|Bacteria,2GJ4P@201174|Actinobacteria,2NEFZ@228398|Streptacidiphilus	201174|Actinobacteria	L	recA bacterial DNA recombination protein	recA	GO:0000150,GO:0000166,GO:0000287,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009650,GO:0009987,GO:0009991,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030145,GO:0030554,GO:0031668,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042148,GO:0042221,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
k59_1596067_1	349521.HCH_03207	2.52e-83	267.0	COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,1RNA5@1236|Gammaproteobacteria,1XHQB@135619|Oceanospirillales	135619|Oceanospirillales	P	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity	katG	-	1.11.1.21	ko:K03782	ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110	-	R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906	RC00034,RC00213,RC00767,RC02141	ko00000,ko00001,ko01000	-	-	-	peroxidase
k59_594110_2	1313172.YM304_07450	1.56e-88	281.0	COG3808@1|root,COG3808@2|Bacteria,2GN8B@201174|Actinobacteria	201174|Actinobacteria	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
k59_594126_1	1137799.GZ78_27920	2.48e-30	120.0	COG3519@1|root,COG3519@2|Bacteria,1MUY4@1224|Proteobacteria,1RPK4@1236|Gammaproteobacteria,1XJ12@135619|Oceanospirillales	135619|Oceanospirillales	S	Type VI secretion	-	-	-	ko:K11896	-	M00334	-	-	ko00000,ko00002,ko02044	3.A.23.1	-	-	T6SS_TssF
k59_594126_2	1121935.AQXX01000135_gene3727	1.59e-15	73.9	COG3518@1|root,COG3518@2|Bacteria,1RG8W@1224|Proteobacteria,1S50E@1236|Gammaproteobacteria,1XKPK@135619|Oceanospirillales	135619|Oceanospirillales	S	Gene 25-like lysozyme	-	-	-	ko:K11897	-	M00334	-	-	ko00000,ko00002,ko02044	-	-	-	GPW_gp25
k59_539064_1	215803.DB30_0647	7.3e-107	342.0	COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,42NAW@68525|delta/epsilon subdivisions,2WISU@28221|Deltaproteobacteria,2YUJI@29|Myxococcales	28221|Deltaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_1539048_1	1173263.Syn7502_03337	1.04e-67	221.0	COG0277@1|root,COG0277@2|Bacteria,1G1U2@1117|Cyanobacteria,1GZG1@1129|Synechococcus	1117|Cyanobacteria	C	Glycolate oxidase subunit GlcD	glcD	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_1041927_1	926550.CLDAP_19050	6.65e-68	220.0	COG0160@1|root,COG0160@2|Bacteria,2G5KN@200795|Chloroflexi	200795|Chloroflexi	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.19	ko:K00823	ko00250,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_648475_1	504728.K649_00480	8.11e-61	195.0	COG4221@1|root,COG4221@2|Bacteria,1WID9@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_260107_1	582515.KR51_00014430	1.45e-54	185.0	COG1819@1|root,COG1819@2|Bacteria,1G036@1117|Cyanobacteria	1117|Cyanobacteria	CG	Glycosyltransferase family 28 N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_28
k59_1041930_1	62928.azo2955	4.15e-62	216.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2VHCZ@28216|Betaproteobacteria,2KUGU@206389|Rhodocyclales	206389|Rhodocyclales	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	cusA	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	-	ACR_tran
k59_94252_1	944435.AXAJ01000001_gene74	1.41e-85	271.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2VHKU@28216|Betaproteobacteria,1K17A@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	-	-	-	-	-	-	-	-	-	TctA,TctB
k59_1151606_1	981369.JQMJ01000004_gene6109	8.88e-93	292.0	COG1331@1|root,COG1331@2|Bacteria,2GJ88@201174|Actinobacteria,2NFMB@228398|Streptacidiphilus	201174|Actinobacteria	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
k59_1596122_1	1033732.CAHI01000003_gene2389	3.47e-52	186.0	COG3250@1|root,COG3250@2|Bacteria,4NEDF@976|Bacteroidetes,2FMTQ@200643|Bacteroidia,22UBI@171550|Rikenellaceae	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 2 family	-	-	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N,Malectin
k59_1649165_1	929713.NIASO_04475	1.61e-40	156.0	COG3391@1|root,COG3511@1|root,COG3391@2|Bacteria,COG3511@2|Bacteria,4NGKT@976|Bacteroidetes,1IW42@117747|Sphingobacteriia	976|Bacteroidetes	M	Phosphoesterase family	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase,Phosphoesterase
k59_260144_1	246194.CHY_1740	1e-37	135.0	COG1250@1|root,COG1250@2|Bacteria,1TPA4@1239|Firmicutes,24DBH@186801|Clostridia,42I3U@68295|Thermoanaerobacterales	186801|Clostridia	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
k59_260144_2	1120972.AUMH01000004_gene1472	4.94e-27	108.0	COG0183@1|root,COG0183@2|Bacteria,1TP07@1239|Firmicutes,4H9RJ@91061|Bacilli,277YV@186823|Alicyclobacillaceae	91061|Bacilli	I	Belongs to the thiolase family	pcaF	-	2.3.1.174,2.3.1.223,2.3.1.9	ko:K00626,ko:K02615	ko00071,ko00072,ko00280,ko00310,ko00360,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00360,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R00829,R01177,R09839	RC00004,RC00326,RC03003	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_94301_2	1415166.NONO_c59940	1.03e-12	67.4	2ECPY@1|root,336MN@2|Bacteria,2GR5C@201174|Actinobacteria,4G4Z9@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1539101_1	1049564.TevJSym_ak00930	1.61e-76	234.0	COG0120@1|root,COG0120@2|Bacteria,1MVGR@1224|Proteobacteria,1RNF8@1236|Gammaproteobacteria,1J5G3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	G	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate	rpiA	GO:0003674,GO:0003824,GO:0004751,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006014,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009987,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0042802,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564	5.3.1.6	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056	RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	Rib_5-P_isom_A
k59_1760604_1	1122611.KB903953_gene5729	2.27e-22	94.0	COG0436@1|root,COG0436@2|Bacteria,2GTYR@201174|Actinobacteria	201174|Actinobacteria	E	Aminotransferase	-	-	2.9.1.1	ko:K01042	ko00450,ko00970,map00450,map00970	-	R08219	RC01246	ko00000,ko00001,ko01000	-	-	-	-
k59_872139_1	1123070.KB899257_gene2274	5.08e-101	308.0	COG3119@1|root,COG3119@2|Bacteria,46TR4@74201|Verrucomicrobia,2IV34@203494|Verrucomicrobiae	203494|Verrucomicrobiae	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
k59_260160_1	314278.NB231_07652	4.21e-83	254.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,1RP3G@1236|Gammaproteobacteria,1WXRY@135613|Chromatiales	135613|Chromatiales	C	Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase	-	-	1.2.4.1	ko:K00162,ko:K21417	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
k59_149145_1	575588.ACPN01000205_gene132	9.39e-11	58.9	arCOG05874@1|root,2ZJ01@2|Bacteria,1N8VY@1224|Proteobacteria,1TDBR@1236|Gammaproteobacteria,3NQIQ@468|Moraxellaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_761324_2	521098.Aaci_0157	4.58e-29	115.0	COG1028@1|root,COG1028@2|Bacteria,1UETI@1239|Firmicutes,4HB6V@91061|Bacilli,279MG@186823|Alicyclobacillaceae	91061|Bacilli	IQ	PFAM short-chain dehydrogenase reductase SDR	fabG_4	-	1.1.1.69	ko:K00046	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
k59_204196_1	1397666.RS24_01701	5.91e-64	216.0	COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,2TRQN@28211|Alphaproteobacteria,4BPK3@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
k59_1264359_1	1353531.AZNX01000003_gene2931	4.99e-95	286.0	COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria,2TS02@28211|Alphaproteobacteria,4B9I7@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_872160_1	572477.Alvin_1965	5.89e-49	166.0	COG1087@1|root,COG1087@2|Bacteria,1MUHI@1224|Proteobacteria,1RMTU@1236|Gammaproteobacteria,1WWNR@135613|Chromatiales	135613|Chromatiales	M	Belongs to the NAD(P)-dependent epimerase dehydratase family	-	-	5.1.3.2,5.1.3.5	ko:K01784,ko:K12448	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R01473,R02984	RC00289,RC00528	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
k59_94338_1	1004785.AMBLS11_16995	1.19e-27	112.0	COG3735@1|root,COG3735@2|Bacteria,1MVCW@1224|Proteobacteria,1RRI8@1236|Gammaproteobacteria,4659X@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	protein conserved in bacteria	ybaP	-	-	ko:K09973	-	-	-	-	ko00000	-	-	-	TraB
k59_94351_1	323097.Nham_2531	4.6e-42	158.0	COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,2TSAJ@28211|Alphaproteobacteria,3JWMN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Glycosyl hydrolase 36 superfamily, catalytic domain	ndvB	GO:0003674,GO:0003824,GO:0016740,GO:0016757	2.4.1.321	ko:K13688,ko:K18786	-	-	R10832	RC00397	ko00000,ko01000,ko01003	-	GH94,GT84	-	Glyco_hydro_36,Glyco_transf_36,Glycoamylase
k59_204224_1	1082933.MEA186_30712	1.22e-87	280.0	COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,2TS8I@28211|Alphaproteobacteria,43HNG@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family	nirB	-	1.7.1.15	ko:K00362	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2,Rieske_2
k59_1319194_1	933262.AXAM01000018_gene1006	1.74e-17	86.3	COG2271@1|root,COG2271@2|Bacteria	2|Bacteria	G	transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
k59_1708636_1	909663.KI867150_gene1668	6.77e-12	71.2	COG1596@1|root,COG1596@2|Bacteria,1N7GP@1224|Proteobacteria,42M62@68525|delta/epsilon subdivisions,2WJ83@28221|Deltaproteobacteria,2MQAJ@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Polysaccharide biosynthesis/export protein	-	-	-	-	-	-	-	-	-	-	-	-	Caps_synth_GfcC,Poly_export,SLBB
k59_94358_1	66377.JOBH01000014_gene4739	2.64e-31	118.0	COG0300@1|root,COG0300@2|Bacteria,2GKJE@201174|Actinobacteria	201174|Actinobacteria	P	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
k59_94358_2	1869.MB27_17770	8.69e-05	45.1	COG0542@1|root,COG0542@2|Bacteria,2GJ73@201174|Actinobacteria,4DAJ3@85008|Micromonosporales	201174|Actinobacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695,ko:K03696	ko01100,ko04213,map01100,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_318201_1	1177179.A11A3_00055	7.63e-21	96.7	COG4783@1|root,COG4783@2|Bacteria,1QZ9X@1224|Proteobacteria,1T42R@1236|Gammaproteobacteria,1XRWC@135619|Oceanospirillales	135619|Oceanospirillales	S	chaperone-mediated protein folding	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
k59_707297_1	113395.AXAI01000014_gene254	5.6e-54	177.0	COG1309@1|root,COG1309@2|Bacteria,1RDIM@1224|Proteobacteria,2VEVK@28211|Alphaproteobacteria,3JVBT@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	Bacterial regulatory proteins, tetR family	MA20_26620	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_427929_1	1403819.BATR01000114_gene3909	7.26e-85	272.0	COG2304@1|root,COG2304@2|Bacteria,46XD8@74201|Verrucomicrobia,2IVI0@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Vault protein inter-alpha-trypsin domain	-	-	-	-	-	-	-	-	-	-	-	-	VIT
k59_817182_1	1205680.CAKO01000040_gene693	4.67e-63	207.0	COG2175@1|root,COG2175@2|Bacteria,1Q0C7@1224|Proteobacteria,2TRGF@28211|Alphaproteobacteria,2JV63@204441|Rhodospirillales	204441|Rhodospirillales	Q	Taurine catabolism dioxygenase TauD, TfdA family	-	-	-	-	-	-	-	-	-	-	-	-	TauD
k59_94387_1	1379270.AUXF01000003_gene3404	1.13e-93	288.0	COG1206@1|root,COG1206@2|Bacteria,1ZTB8@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs	gid	-	2.1.1.74	ko:K04094	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	GIDA
k59_485816_1	1313172.YM304_04120	2.74e-69	236.0	COG1034@1|root,COG1034@2|Bacteria,2GJGX@201174|Actinobacteria,4CMPH@84992|Acidimicrobiia	84992|Acidimicrobiia	C	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region	-	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdop_Fe4S4,Molybdopterin,NADH-G_4Fe-4S_3
k59_1596261_1	909663.KI867150_gene333	5.9e-59	201.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,42MMV@68525|delta/epsilon subdivisions,2WIZ4@28221|Deltaproteobacteria,2MQB9@213462|Syntrophobacterales	28221|Deltaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	-	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SecA_DEAD,SecA_PP_bind
k59_204268_1	1207063.P24_04634	1.19e-82	258.0	COG0765@1|root,COG0765@2|Bacteria,1MV3I@1224|Proteobacteria,2TR9C@28211|Alphaproteobacteria,2JPI5@204441|Rhodospirillales	204441|Rhodospirillales	E	COG0765 ABC-type amino acid transport system, permease component	-	-	-	ko:K09971	ko02010,map02010	M00232	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	BPD_transp_1
k59_817197_2	999630.TUZN_0370	3.35e-34	127.0	COG0500@1|root,arCOG01631@2157|Archaea,2XQ7P@28889|Crenarchaeota	28889|Crenarchaeota	Q	RNA methylase	-	GO:0003674,GO:0003824,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016278,GO:0016279,GO:0016740,GO:0016741,GO:0018022,GO:0018193,GO:0018205,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:0140096,GO:1901564	-	-	-	-	-	-	-	-	-	-	CMAS,DOT1,Methyltransf_25,Methyltransf_31,PrmA
k59_1428786_1	1248916.ANFY01000007_gene2540	5.47e-45	152.0	COG3350@1|root,COG3350@2|Bacteria,1N0GC@1224|Proteobacteria,2UBRM@28211|Alphaproteobacteria,2K7KU@204457|Sphingomonadales	204457|Sphingomonadales	S	YHS domain protein	-	-	-	-	-	-	-	-	-	-	-	-	YHS
k59_594309_1	1122622.ATWJ01000008_gene2911	5.64e-56	196.0	COG0737@1|root,COG2247@1|root,COG0737@2|Bacteria,COG2247@2|Bacteria,2GKC3@201174|Actinobacteria,4FEPR@85021|Intrasporangiaceae	201174|Actinobacteria	F	Belongs to the 5'-nucleotidase family	-	-	3.1.3.5	ko:K01081	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,Metallophos
k59_427964_1	264732.Moth_2460	3.04e-12	64.7	COG0087@1|root,COG0087@2|Bacteria,1TPFT@1239|Firmicutes,247NH@186801|Clostridia,42FAS@68295|Thermoanaerobacterales	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
k59_1487410_1	240015.ACP_0721	3.32e-87	273.0	COG0459@1|root,COG0459@2|Bacteria,3Y37I@57723|Acidobacteria,2JIV1@204432|Acidobacteriia	204432|Acidobacteriia	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
k59_40200_1	1131553.JIBI01000002_gene1775	1.32e-18	88.2	COG1009@1|root,COG2111@1|root,COG1009@2|Bacteria,COG2111@2|Bacteria,1MW2M@1224|Proteobacteria,2VK56@28216|Betaproteobacteria,371RV@32003|Nitrosomonadales	28216|Betaproteobacteria	CP	Domain related to MnhB subunit of Na+/H+ antiporter	-	-	-	ko:K05559	-	-	-	-	ko00000,ko02000	2.A.63.1	-	-	DUF4040,MnhB,Proton_antipo_M,Proton_antipo_N
k59_1321407_1	477974.Daud_0866	1.63e-67	225.0	COG1640@1|root,COG1640@2|Bacteria,1W5VQ@1239|Firmicutes,25E46@186801|Clostridia,2610T@186807|Peptococcaceae	186801|Clostridia	G	PFAM glycoside hydrolase family 77	malQ	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
k59_933660_1	886293.Sinac_5955	6.32e-28	119.0	COG1391@1|root,COG1391@2|Bacteria,2IXPE@203682|Planctomycetes	203682|Planctomycetes	H	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	-	-	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
k59_374632_1	63737.Npun_R3027	8.78e-33	129.0	COG0001@1|root,COG0318@1|root,COG1020@1|root,COG3321@1|root,COG0001@2|Bacteria,COG0318@2|Bacteria,COG1020@2|Bacteria,COG3321@2|Bacteria,1FZXE@1117|Cyanobacteria,1HIST@1161|Nostocales	1117|Cyanobacteria	Q	acyl transferase domain	-	-	-	ko:K16129	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Aminotran_3,Bac_luciferase,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,ketoacyl-synt
k59_374632_2	448385.sce8262	1.17e-26	108.0	COG0318@1|root,COG1020@1|root,COG0318@2|Bacteria,COG1020@2|Bacteria,1MU6G@1224|Proteobacteria,43C6Z@68525|delta/epsilon subdivisions,2X7UA@28221|Deltaproteobacteria,2Z3KU@29|Myxococcales	28221|Deltaproteobacteria	IQ	Pfam:HxxPF_rpt	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
k59_1044280_1	399795.CtesDRAFT_PD4900	2.44e-60	199.0	COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,2WEXA@28216|Betaproteobacteria,4AHE4@80864|Comamonadaceae	28216|Betaproteobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_1044280_2	1056512.D515_02281	0.000279	42.4	COG2358@1|root,COG2358@2|Bacteria,1NSTZ@1224|Proteobacteria,1RP8B@1236|Gammaproteobacteria,1XTE6@135623|Vibrionales	135623|Vibrionales	S	NMT1-like family	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
k59_487790_1	865937.Gilli_2267	9.62e-75	234.0	COG2273@1|root,COG2273@2|Bacteria,4P0M2@976|Bacteroidetes,1I8B0@117743|Flavobacteriia	976|Bacteroidetes	G	Glycosyl hydrolases family 16	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_16
k59_206257_1	861299.J421_3077	2.42e-49	172.0	COG0773@1|root,COG0773@2|Bacteria,1ZSQG@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_933693_1	926569.ANT_10040	8.19e-78	236.0	COG0087@1|root,COG0087@2|Bacteria,2G6DQ@200795|Chloroflexi	200795|Chloroflexi	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
k59_1651384_1	926569.ANT_19800	5.43e-33	129.0	COG0210@1|root,COG0210@2|Bacteria,2G7VU@200795|Chloroflexi	200795|Chloroflexi	F	DNA helicase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1431014_1	1307761.L21SP2_1482	2.06e-76	239.0	COG3221@1|root,COG3221@2|Bacteria	2|Bacteria	P	organic phosphonate transport	phnD	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	Phosphonate-bd
k59_1710855_1	1264700.L0MZ23_9CAUD	1.22e-21	87.4	4QCH7@10239|Viruses,4QVYY@35237|dsDNA viruses  no RNA stage,4QU62@28883|Caudovirales,4QI4G@10662|Myoviridae	10662|Myoviridae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1710855_2	551895.B5AX75_9CAUD	4.62e-58	189.0	4QDVS@10239|Viruses,4QXKQ@35237|dsDNA viruses  no RNA stage,4QSYC@28883|Caudovirales,4QJV5@10662|Myoviridae	10662|Myoviridae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_552537_1	102125.Xen7305DRAFT_00007060	6.41e-39	138.0	COG0193@1|root,COG0193@2|Bacteria,1G0D0@1117|Cyanobacteria,3VJ60@52604|Pleurocapsales	1117|Cyanobacteria	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
k59_831921_2	1121403.AUCV01000056_gene3021	6.14e-27	110.0	COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,42NUT@68525|delta/epsilon subdivisions,2WKQX@28221|Deltaproteobacteria,2MI5I@213118|Desulfobacterales	28221|Deltaproteobacteria	O	HflC and HflK could encode or regulate a protease	hflK	-	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
k59_1663760_1	404380.Gbem_0088	3.75e-95	308.0	COG2132@1|root,COG2132@2|Bacteria	2|Bacteria	Q	Multicopper oxidase	ompB	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase_2,fn3
k59_442715_1	309801.trd_A0026	3.14e-45	154.0	COG1079@1|root,COG1079@2|Bacteria,2GAAR@200795|Chloroflexi,27Z2F@189775|Thermomicrobia	189775|Thermomicrobia	S	Branched-chain amino acid transport system / permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
k59_552552_1	269796.Rru_A2664	4.2e-55	181.0	COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,2TSI0@28211|Alphaproteobacteria,2JQSR@204441|Rhodospirillales	204441|Rhodospirillales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	-	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
k59_552552_2	1207063.P24_12896	3.82e-22	89.0	COG0203@1|root,COG0203@2|Bacteria,1RCWN@1224|Proteobacteria,2U749@28211|Alphaproteobacteria,2JS6K@204441|Rhodospirillales	204441|Rhodospirillales	J	structural constituent of ribosome	rplQ	-	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
k59_662488_1	1158150.KB906242_gene478	2.71e-76	246.0	COG0301@1|root,COG0607@1|root,COG0301@2|Bacteria,COG0607@2|Bacteria,1MWD3@1224|Proteobacteria,1RNZT@1236|Gammaproteobacteria,1X0QW@135613|Chromatiales	135613|Chromatiales	HP	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	thiI	-	2.8.1.4	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07461	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Rhodanese,THUMP,ThiI
k59_52409_1	926569.ANT_27550	1.96e-67	213.0	COG5032@1|root,COG5032@2|Bacteria,2G6FZ@200795|Chloroflexi	200795|Chloroflexi	BDLTU	phosphatidylinositol kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	PI3_PI4_kinase
k59_1610330_1	1286171.EAL2_808p05590	0.000501	44.7	COG0162@1|root,COG0162@2|Bacteria,1TPGN@1239|Firmicutes,247QC@186801|Clostridia,25URF@186806|Eubacteriaceae	186801|Clostridia	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
k59_889047_1	266779.Meso_2458	1.07e-22	102.0	COG0500@1|root,COG2267@1|root,COG2226@2|Bacteria,COG2267@2|Bacteria,1NWX3@1224|Proteobacteria,2TURQ@28211|Alphaproteobacteria,43PQD@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Ubie_methyltran
k59_1610334_1	270374.MELB17_13582	4.46e-37	139.0	COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,1RYPY@1236|Gammaproteobacteria,467IX@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Putative transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
k59_387078_1	1122929.KB908218_gene1529	3.44e-36	127.0	COG2009@1|root,COG2009@2|Bacteria,1N02N@1224|Proteobacteria,2UC47@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	succinate dehydrogenase	sdhC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
k59_164539_1	1245471.PCA10_00170	3.08e-85	265.0	COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,1RNVQ@1236|Gammaproteobacteria,1YDXI@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	P	TrkA-N domain	trkA	GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0015075,GO:0015672,GO:0016020,GO:0022857,GO:0030001,GO:0034220,GO:0051179,GO:0051234,GO:0055085,GO:0098655	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	iE2348C_1286.E2348C_3552	TrkA_C,TrkA_N
k59_164547_1	887898.HMPREF0551_0062	3e-39	148.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,2VHBY@28216|Betaproteobacteria,1K2P0@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Asparagine synthase	asnB	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
k59_387088_1	1121104.AQXH01000004_gene63	8.22e-42	154.0	COG1228@1|root,COG1228@2|Bacteria,4NEV0@976|Bacteroidetes,1IWPE@117747|Sphingobacteriia	976|Bacteroidetes	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_1443551_1	1235797.C816_01955	3.09e-26	108.0	COG2264@1|root,COG2264@2|Bacteria,1TPKI@1239|Firmicutes,247VY@186801|Clostridia,2N6ID@216572|Oscillospiraceae	186801|Clostridia	J	Ribosomal protein L11 methyltransferase	prmA	-	-	ko:K02687	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PrmA
k59_52440_1	1157943.KB892705_gene2336	2.71e-75	256.0	COG0515@1|root,COG3903@1|root,COG0515@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,233DM@1762|Mycobacteriaceae	201174|Actinobacteria	K	involved in signal transduction (via phosphorylation) involved in transcriptional regulatory mechanism and in the regulation of secondary metabolites catalytic activity ATP a protein ADP a phosphoprotein	pknK_2	-	2.7.11.1	ko:K08282	-	-	-	-	ko00000,ko01000	-	-	-	AAA_22,GerE,NB-ARC,Pkinase,TPR_12
k59_273248_1	260799.BAS3933	1.06e-36	131.0	COG1051@1|root,COG1051@2|Bacteria,1V94E@1239|Firmicutes,4HJDX@91061|Bacilli,1ZQ2M@1386|Bacillus	91061|Bacilli	F	Belongs to the Nudix hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
k59_606950_1	926569.ANT_12120	1.51e-42	152.0	COG0726@1|root,COG0726@2|Bacteria	2|Bacteria	G	polysaccharide deacetylase	-	-	3.4.24.40	ko:K01406	ko01503,map01503	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Cadherin,HemolysinCabind,Peptidase_M10_C,Polysacc_deac_1
k59_442787_1	1120983.KB894571_gene2089	3.06e-63	206.0	COG1638@1|root,COG1638@2|Bacteria,1NTFS@1224|Proteobacteria,2U1QM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	transport system periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_1443577_1	1191523.MROS_0727	2.32e-57	201.0	COG0436@1|root,COG0436@2|Bacteria	2|Bacteria	E	Aminotransferase	-	-	-	ko:K21572	-	-	-	-	ko00000,ko02000	8.A.46.1,8.A.46.3	-	-	SusD-like_3,SusD_RagB
k59_442796_1	1121481.AUAS01000003_gene3739	5.65e-29	120.0	COG2931@1|root,COG5184@1|root,COG2931@2|Bacteria,COG5184@2|Bacteria,4NKIR@976|Bacteroidetes,47S7V@768503|Cytophagia	976|Bacteroidetes	Q	SMART Integrin alpha beta-propellor repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,FG-GAP,HYR,VCBS
k59_442801_1	1082933.MEA186_28812	9.17e-12	70.5	COG0477@1|root,COG0477@2|Bacteria,1MXZ3@1224|Proteobacteria,2TSHC@28211|Alphaproteobacteria,43IB0@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	EGP	PFAM Bacterial protein of	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
k59_273283_1	90814.KL370892_gene2243	1.38e-67	230.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,45ZUW@72273|Thiotrichales	72273|Thiotrichales	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_774532_1	1445613.JALM01000116_gene2430	1.23e-36	135.0	COG0179@1|root,COG0179@2|Bacteria,2GKED@201174|Actinobacteria,4E864@85010|Pseudonocardiales	201174|Actinobacteria	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
k59_442824_2	391619.PGA1_c16210	1.23e-71	218.0	COG2080@1|root,COG2080@2|Bacteria,1RB3F@1224|Proteobacteria,2VF0C@28211|Alphaproteobacteria,34G4I@302485|Phaeobacter	28211|Alphaproteobacteria	C	[2Fe-2S] binding domain	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
k59_1551992_1	1115803.HMPREF1129_1027	1.27e-34	131.0	COG0468@1|root,COG0468@2|Bacteria,2GJ4P@201174|Actinobacteria,4D3IF@85005|Actinomycetales	201174|Actinobacteria	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	GO:0000150,GO:0000166,GO:0000287,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009650,GO:0009987,GO:0009991,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030145,GO:0030554,GO:0031668,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042148,GO:0042221,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
k59_52515_1	1136535.I6NV36_9CAUD	6.17e-94	298.0	4QCM6@10239|Viruses,4QVAQ@35237|dsDNA viruses  no RNA stage,4QPVV@28883|Caudovirales,4QNID@10744|Podoviridae	10744|Podoviridae	S	actin binding	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1219738_1	713587.THITH_13225	1.56e-22	105.0	COG0421@1|root,COG0421@2|Bacteria,1P220@1224|Proteobacteria,1T553@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	-	-	-	-	-	-	-	-	-	-	Spermine_synth
k59_607020_2	861299.J421_4367	8.36e-18	82.8	COG1051@1|root,COG1051@2|Bacteria,1ZU0E@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
k59_998735_1	391937.NA2_02814	7.31e-24	100.0	28MZG@1|root,2ZB66@2|Bacteria,1R6ZF@1224|Proteobacteria,2U3DX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
k59_889243_1	1122915.AUGY01000083_gene4475	1.02e-22	100.0	COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,1TQY5@1239|Firmicutes,4HAF6@91061|Bacilli,270F8@186822|Paenibacillaceae	91061|Bacilli	KT	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GAF_2,RsbU_N,SpoIIE
k59_662660_1	1127673.GLIP_2033	2.32e-29	111.0	COG5587@1|root,COG5587@2|Bacteria,1R8B4@1224|Proteobacteria,1S1WW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	PFAM conserved	-	-	-	-	-	-	-	-	-	-	-	-	DUF2461
k59_832118_1	926569.ANT_22620	2.1e-89	281.0	COG1086@1|root,COG1086@2|Bacteria,2G5M8@200795|Chloroflexi	200795|Chloroflexi	GM	Short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_3,Polysacc_synt_2
k59_552692_1	243230.DR_A0330	3.92e-26	111.0	COG1502@1|root,COG1502@2|Bacteria	2|Bacteria	I	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_2
k59_774612_1	671143.DAMO_0750	2.54e-48	167.0	COG4122@1|root,COG4122@2|Bacteria,2NQFB@2323|unclassified Bacteria	2|Bacteria	S	Pup-ligase protein	dop	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006464,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0016810,GO:0016811,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0051603,GO:0070490,GO:0070647,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	3.5.1.119	ko:K20814	-	-	-	-	ko00000,ko01000,ko03051	-	-	-	Pup_ligase
k59_607053_1	518766.Rmar_0729	1.16e-67	216.0	COG1208@1|root,COG1208@2|Bacteria,4NE97@976|Bacteroidetes,1FJ50@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	JM	Nucleotidyl transferase	rffH	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
k59_387207_1	991905.SL003B_4075	7.13e-69	224.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria	1224|Proteobacteria	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_38,HTH_7,rve
k59_1610526_1	1125863.JAFN01000001_gene374	8.57e-25	99.0	COG1975@1|root,COG1975@2|Bacteria	2|Bacteria	O	molybdopterin cofactor binding	xdhC	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
k59_1610526_2	1120941.AUBL01000064_gene2110	1.76e-26	107.0	COG0667@1|root,COG0667@2|Bacteria,2GMT5@201174|Actinobacteria,4D4BK@85005|Actinomycetales	201174|Actinobacteria	C	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_998768_1	511.JT27_17210	1.22e-26	115.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,2VJ5Q@28216|Betaproteobacteria,3T1F3@506|Alcaligenaceae	28216|Betaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_998768_2	1157490.EL26_03925	1.22e-95	289.0	COG0667@1|root,COG0667@2|Bacteria,1TRS0@1239|Firmicutes,4HBX5@91061|Bacilli,279G5@186823|Alicyclobacillaceae	91061|Bacilli	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_273395_1	316274.Haur_3500	3.05e-18	87.8	COG0601@1|root,COG0601@2|Bacteria,2G68Q@200795|Chloroflexi,374T4@32061|Chloroflexia	32061|Chloroflexia	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_1219809_1	571166.KI421510_gene255	2.02e-29	120.0	COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,2TUQT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_889319_1	443144.GM21_0115	6.22e-48	175.0	COG3280@1|root,COG3280@2|Bacteria,1QTVK@1224|Proteobacteria,42MEW@68525|delta/epsilon subdivisions,2WJX1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	TIGRFAM Malto-oligosyltrehalose synthase	treY	-	5.4.99.15	ko:K06044	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01824,R09995	-	ko00000,ko00001,ko00002,ko01000	-	GH13	-	Alpha-amylase
k59_832188_1	1120956.JHZK01000039_gene3109	5.38e-70	225.0	COG0438@1|root,COG0438@2|Bacteria,1N0DG@1224|Proteobacteria,2TU8I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_2,Glyco_trans_4_4,Glycos_transf_1
k59_1610584_1	1174504.AJTN02000035_gene3039	1e-27	110.0	COG1960@1|root,COG1960@2|Bacteria,1TSVJ@1239|Firmicutes,4H9RM@91061|Bacilli,1ZCN6@1386|Bacillus	91061|Bacilli	I	Acyl-CoA dehydrogenase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_1610584_2	405948.SACE_2330	6.89e-50	164.0	COG2030@1|root,COG2030@2|Bacteria,2GN4R@201174|Actinobacteria,4DZ99@85010|Pseudonocardiales	201174|Actinobacteria	I	MaoC like domain	-	-	4.2.1.56	ko:K18290	ko00660,map00660	-	R02491	RC00730	ko00000,ko00001,ko01000	-	-	-	MaoC_dehydratas
k59_108592_2	266748.HY04_05260	1.48e-16	80.1	COG2202@1|root,COG5002@1|root,COG2202@2|Bacteria,COG5002@2|Bacteria,4PM0I@976|Bacteroidetes,1IJIA@117743|Flavobacteriia,3ZQIT@59732|Chryseobacterium	976|Bacteroidetes	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_8,PAS_9
k59_774692_1	926569.ANT_18650	1.12e-51	174.0	COG1131@1|root,COG1131@2|Bacteria,2G5PC@200795|Chloroflexi	200795|Chloroflexi	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
k59_273464_1	1321778.HMPREF1982_03350	8.36e-14	76.3	2BN9R@1|root,32GX8@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_216941_1	492774.JQMB01000011_gene4309	8.46e-62	205.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2TR8H@28211|Alphaproteobacteria,4B80C@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes	lpdA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_216941_2	1122223.KB890696_gene451	2.34e-06	50.8	COG0321@1|root,COG0321@2|Bacteria,1WIJ7@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
k59_1443837_1	880073.Calab_1134	2.84e-22	103.0	COG2091@1|root,COG2091@2|Bacteria,2NQGR@2323|unclassified Bacteria	2|Bacteria	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
k59_1057006_1	582402.Hbal_2597	7.49e-35	136.0	COG4774@1|root,COG4774@2|Bacteria,1NMCN@1224|Proteobacteria	1224|Proteobacteria	P	COG1629 Outer membrane receptor proteins, mostly Fe transport	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
k59_1446207_1	994573.T472_0205330	2.15e-72	239.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,36QC0@31979|Clostridiaceae	186801|Clostridia	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
k59_667858_1	398527.Bphyt_6647	1.65e-44	159.0	COG3119@1|root,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,2VNBG@28216|Betaproteobacteria,1K297@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Pfam Sulfatase	-	-	3.1.6.6	ko:K01133	-	-	-	-	ko00000,ko01000	-	-	-	DUF4976,Sulfatase
k59_334247_1	1449350.OCH239_03905	1.82e-90	269.0	COG3335@1|root,COG3335@2|Bacteria,1P76X@1224|Proteobacteria,2U16U@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
k59_1001452_1	1033730.CAHG01000006_gene1203	4.59e-59	199.0	COG0617@1|root,COG0617@2|Bacteria,2GMT1@201174|Actinobacteria,4DMZV@85009|Propionibacteriales	201174|Actinobacteria	J	Probable RNA and SrmB- binding site of polymerase A	pcnA	-	2.7.7.19,2.7.7.72	ko:K00970,ko:K00974	ko03013,ko03018,map03013,map03018	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd
k59_945841_1	244581.IM40_02095	1.19e-51	168.0	COG0097@1|root,COG0097@2|Bacteria,1R9YZ@1224|Proteobacteria,2TV09@28211|Alphaproteobacteria,47FCI@766|Rickettsiales	766|Rickettsiales	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	-	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
k59_945841_2	991905.SL003B_1755	6.79e-49	159.0	COG0256@1|root,COG0256@2|Bacteria,1RGY7@1224|Proteobacteria,2U9A6@28211|Alphaproteobacteria,4BQKP@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
k59_945841_3	909943.HIMB100_00006400	1.24e-84	255.0	COG0098@1|root,COG0098@2|Bacteria,1MUS4@1224|Proteobacteria,2TSRI@28211|Alphaproteobacteria,4BQ0R@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
k59_945841_4	1122137.AQXF01000006_gene958	3.67e-11	58.2	COG1841@1|root,COG1841@2|Bacteria,1PU2S@1224|Proteobacteria,2UF55@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Ribosomal protein L30	rpmD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
k59_1612940_1	1123508.JH636440_gene1973	2.6e-09	58.2	COG1595@1|root,COG1595@2|Bacteria,2J0GI@203682|Planctomycetes	203682|Planctomycetes	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_1557394_1	288705.RSal33209_2576	2.02e-26	110.0	COG0600@1|root,COG0600@2|Bacteria,2GKKZ@201174|Actinobacteria,1W8T5@1268|Micrococcaceae	201174|Actinobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
k59_945855_1	1499968.TCA2_5112	4.13e-56	193.0	COG0449@1|root,COG0449@2|Bacteria,1TPGU@1239|Firmicutes,4H9R4@91061|Bacilli,26QAT@186822|Paenibacillaceae	91061|Bacilli	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
k59_278687_2	861299.J421_3749	4.09e-45	155.0	COG1721@1|root,COG1721@2|Bacteria,1ZT0H@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
k59_945857_1	1480694.DC28_15440	4.68e-23	99.4	COG3328@1|root,COG3328@2|Bacteria,2J57X@203691|Spirochaetes	203691|Spirochaetes	L	PFAM Transposase, Mutator family	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_1446253_1	391937.NA2_01125	1.12e-29	115.0	COG3285@1|root,COG3285@2|Bacteria,1MVWY@1224|Proteobacteria,2TRSZ@28211|Alphaproteobacteria,43IJ1@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	L	DNA ligase	ligD	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
k59_1446253_2	1158294.JOMI01000007_gene54	0.000325	42.4	COG3118@1|root,COG3118@2|Bacteria,4NWFX@976|Bacteroidetes,2FUZC@200643|Bacteroidia	976|Bacteroidetes	O	Thioredoxin	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
k59_1390621_1	768671.ThimaDRAFT_3156	2.54e-30	114.0	COG2230@1|root,COG2230@2|Bacteria,1QUR4@1224|Proteobacteria,1RP3C@1236|Gammaproteobacteria,1WX7D@135613|Chromatiales	135613|Chromatiales	M	Methyltransferase	-	-	2.1.1.157	ko:K18897	ko00260,map00260	-	R10061	RC00003,RC03040	ko00000,ko00001,ko01000	-	-	-	Methyltransf_11
k59_1390621_2	1238182.C882_0544	1.04e-40	144.0	COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,2TR4P@28211|Alphaproteobacteria,2JQ8W@204441|Rhodospirillales	204441|Rhodospirillales	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	-	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
k59_1223871_1	760568.Desku_2951	6.95e-16	78.2	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,2604P@186807|Peptococcaceae	186801|Clostridia	C	PFAM Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
k59_111950_1	485913.Krac_0317	8.59e-62	206.0	COG3547@1|root,COG3547@2|Bacteria	2|Bacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_779_1	1485545.JQLW01000006_gene485	5.85e-22	94.7	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria	1224|Proteobacteria	C	COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes	lpdA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_7157_2	298654.FraEuI1c_1325	0.000641	41.6	COG2197@1|root,COG2197@2|Bacteria,2IHF7@201174|Actinobacteria	201174|Actinobacteria	T	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_396072_1	926569.ANT_15080	0.000561	48.1	COG1572@1|root,COG1572@2|Bacteria,2G9M8@200795|Chloroflexi	2|Bacteria	S	Ig-like domain from next to BRCA1 gene	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,N_BRCA1_IG
k59_1119164_1	1540221.JQNI01000002_gene2076	1.5e-33	127.0	COG0825@1|root,COG0825@2|Bacteria,1WJ82@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA	accA	-	2.1.3.15,6.4.1.2	ko:K01962	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	ACCA
k59_507352_1	926569.ANT_18100	1.63e-86	266.0	COG4992@1|root,COG4992@2|Bacteria	2|Bacteria	E	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity	rocD	GO:0003674,GO:0003824,GO:0004587,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016740,GO:0016769,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	2.6.1.11,2.6.1.13,2.6.1.17	ko:K00819,ko:K00821	ko00220,ko00300,ko00330,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map00330,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R00667,R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iYO844.BSU40340	Aminotran_3
k59_1563569_1	575540.Isop_1258	5.08e-32	126.0	COG1228@1|root,COG1228@2|Bacteria,2J0GA@203682|Planctomycetes	203682|Planctomycetes	Q	COGs COG1228 Imidazolonepropionase and related amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_1674780_1	861299.J421_3463	6.25e-16	80.5	COG1193@1|root,COG1193@2|Bacteria,1ZSWM@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_V,Smr
k59_1674780_2	1163408.UU9_10027	2.78e-14	72.0	COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,1RMGA@1236|Gammaproteobacteria,1X4K0@135614|Xanthomonadales	135614|Xanthomonadales	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,DnaG_DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
k59_1007825_1	357808.RoseRS_2905	1.68e-61	213.0	COG0236@1|root,COG0304@1|root,COG1028@1|root,COG3321@1|root,COG0236@2|Bacteria,COG0304@2|Bacteria,COG1028@2|Bacteria,COG3321@2|Bacteria,2G68I@200795|Chloroflexi,3765Y@32061|Chloroflexia	32061|Chloroflexia	IQ	PFAM short-chain dehydrogenase reductase SDR	-	-	-	ko:K15314	ko01059,ko01130,map01059,map01130	M00824,M00825	R11435	-	ko00000,ko00001,ko00002,ko01008	-	-	-	Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
k59_1063149_1	1408304.JAHA01000019_gene2237	2.5e-11	69.7	2DD4S@1|root,2ZGHJ@2|Bacteria	2|Bacteria	S	TIR domain	-	-	-	-	-	-	-	-	-	-	-	-	TIR_2
k59_952157_2	1123065.ATWL01000011_gene12	6.67e-13	68.2	COG0742@1|root,COG0742@2|Bacteria,2GQ3G@201174|Actinobacteria	201174|Actinobacteria	L	methyltransferase	rsmD	-	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
k59_840676_1	102125.Xen7305DRAFT_00032600	5.14e-61	196.0	COG1225@1|root,COG1225@2|Bacteria,1G3WF@1117|Cyanobacteria	1117|Cyanobacteria	O	PFAM AhpC TSA family	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
k59_785280_1	264732.Moth_1996	7.15e-50	169.0	COG0078@1|root,COG0078@2|Bacteria,1TPF2@1239|Firmicutes,248I5@186801|Clostridia,42EK4@68295|Thermoanaerobacterales	186801|Clostridia	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	-	2.1.3.3,2.1.3.9	ko:K00611,ko:K09065	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01398,R07245	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_785280_2	1408428.JNJP01000068_gene1269	3.04e-10	60.5	COG0549@1|root,COG0549@2|Bacteria,1MWXC@1224|Proteobacteria,42M16@68525|delta/epsilon subdivisions,2WM0V@28221|Deltaproteobacteria,2MB8H@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Belongs to the carbamate kinase family	cpkA	-	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	-	AA_kinase
k59_1730324_2	118166.JH976537_gene2038	1.02e-72	225.0	COG2818@1|root,COG2818@2|Bacteria,1G5Y1@1117|Cyanobacteria,1HF1X@1150|Oscillatoriales	1117|Cyanobacteria	L	Methyladenine glycosylase	-	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
k59_396116_1	224324.aq_234	9.49e-52	175.0	COG0723@1|root,COG0723@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on diphenols and related substances as donors	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
k59_952175_1	1294143.H681_04485	6.5e-80	247.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,1RMAQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1285643_1	1101188.KI912155_gene3087	2.33e-29	115.0	COG0006@1|root,COG0006@2|Bacteria,2H45Q@201174|Actinobacteria	201174|Actinobacteria	E	Metallopeptidase family M24	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
k59_1285643_2	246196.MSMEI_2113	6.8e-22	94.4	COG3958@1|root,COG3958@2|Bacteria,2I8VM@201174|Actinobacteria,2364F@1762|Mycobacteriaceae	201174|Actinobacteria	G	Transketolase, pyrimidine binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
k59_173730_1	1316936.K678_14617	2.23e-35	126.0	COG0244@1|root,COG0244@2|Bacteria,1RAN5@1224|Proteobacteria,2U592@28211|Alphaproteobacteria,2JS6C@204441|Rhodospirillales	204441|Rhodospirillales	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
k59_1563609_1	1048834.TC41_2960	1.48e-109	330.0	COG0422@1|root,COG0422@2|Bacteria,1TNZ3@1239|Firmicutes,4HC0P@91061|Bacilli	91061|Bacilli	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU08790	ThiC-associated,ThiC_Rad_SAM
k59_1730345_1	399742.Ent638_3583	3.1e-69	218.0	COG0313@1|root,COG0313@2|Bacteria,1MU0E@1224|Proteobacteria,1RM7U@1236|Gammaproteobacteria,3X1KC@547|Enterobacter	1236|Gammaproteobacteria	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070677,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
k59_785310_1	1419583.V466_18180	7.87e-71	229.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RMQQ@1236|Gammaproteobacteria,1YQ3J@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	H	Acetolactate synthase	-	-	1.2.5.1,2.2.1.6,4.1.1.7	ko:K00156,ko:K01576,ko:K01652	ko00290,ko00620,ko00627,ko00650,ko00660,ko00770,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00290,map00620,map00627,map00650,map00660,map00770,map01100,map01110,map01120,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R01764,R02672,R03050,R03145,R04672,R04673,R08648	RC00027,RC00106,RC00595,RC00860,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_618406_1	309801.trd_1712	3.17e-63	210.0	COG0536@1|root,COG0536@2|Bacteria,2G5ZT@200795|Chloroflexi,27XUD@189775|Thermomicrobia	189775|Thermomicrobia	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	DUF1967,GTP1_OBG,MMR_HSR1
k59_618406_2	1453501.JELR01000005_gene1764	2.06e-08	57.0	COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,1RM7X@1236|Gammaproteobacteria,464V7@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	GO:0000287,GO:0003674,GO:0003824,GO:0004349,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019202,GO:0019752,GO:0031406,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0055129,GO:0071704,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901973	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,PUA
k59_1119222_1	1366050.N234_27960	4.41e-36	139.0	COG1961@1|root,COG1961@2|Bacteria,1MVIE@1224|Proteobacteria,2VK01@28216|Betaproteobacteria,1K0XA@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Resolvase domain	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
k59_1285659_1	402881.Plav_1398	1.08e-76	236.0	COG1277@1|root,COG1277@2|Bacteria,1NZZ9@1224|Proteobacteria,2TUXR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	N	ABC transporter permease	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_3
k59_340367_1	991905.SL003B_3938	1.99e-31	120.0	COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,2TQMD@28211|Alphaproteobacteria,4BPG0@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	GM	NmrA-like family	MA20_24380	-	1.6.5.3,1.6.99.3	ko:K00329,ko:K00356	ko00190,map00190	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	3Beta_HSD,Epimerase,NAD_binding_10,RmlD_sub_bind
k59_840720_1	867845.KI911784_gene2258	1.33e-30	113.0	COG1950@1|root,COG1950@2|Bacteria,2G7E6@200795|Chloroflexi,375XQ@32061|Chloroflexia	32061|Chloroflexia	S	PFAM membrane protein of	-	-	-	ko:K08972	-	-	-	-	ko00000	-	-	-	Phage_holin_4_2
k59_507415_1	1540221.JQNI01000002_gene658	3.15e-54	173.0	COG2050@1|root,COG2050@2|Bacteria	2|Bacteria	Q	thiolester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
k59_1007883_1	1120948.KB903247_gene4436	2.59e-39	149.0	COG0542@1|root,COG0542@2|Bacteria,2GJ73@201174|Actinobacteria,4E1A0@85010|Pseudonocardiales	201174|Actinobacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB2	-	-	ko:K03695,ko:K03696	ko01100,ko04213,map01100,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_1230880_1	697303.Thewi_1323	7.5e-43	154.0	COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes,247NQ@186801|Clostridia,42EKB@68295|Thermoanaerobacterales	186801|Clostridia	E	PFAM aminotransferase, class I	aspB	-	2.6.1.1	ko:K00812,ko:K10907	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	iHN637.CLJU_RS06550	Aminotran_1_2
k59_7250_1	1121104.AQXH01000001_gene2071	1.71e-24	102.0	COG1266@1|root,COG1266@2|Bacteria,4NHRW@976|Bacteroidetes	976|Bacteroidetes	S	CAAX amino terminal protease family	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
k59_507428_1	1220589.CD32_22130	1.38e-32	120.0	COG0454@1|root,COG0456@2|Bacteria,1V9FV@1239|Firmicutes,4I41A@91061|Bacilli,3IYYM@400634|Lysinibacillus	91061|Bacilli	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_674358_1	706587.Desti_2324	1.18e-68	224.0	COG1139@1|root,COG1139@2|Bacteria,1MV6J@1224|Proteobacteria,42MN2@68525|delta/epsilon subdivisions,2WIMJ@28221|Deltaproteobacteria,2MR8K@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Pfam:DUF162	-	-	-	ko:K18929	-	-	-	-	ko00000	-	-	-	DUF3390,Fer4_8,LUD_dom
k59_618448_1	194439.CT1406	9.18e-26	108.0	COG0337@1|root,COG0337@2|Bacteria,1FDBH@1090|Chlorobi	1090|Chlorobi	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	4.2.3.4	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03083	RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
k59_896776_1	632335.Calkr_0943	5.31e-36	137.0	COG1085@1|root,COG1085@2|Bacteria,1TS3F@1239|Firmicutes,249P3@186801|Clostridia,42F43@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM Galactose-1-phosphate uridyl transferase	galT	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	GalP_UDP_tr_C,GalP_UDP_transf
k59_118022_1	997346.HMPREF9374_0774	1.8e-36	137.0	COG5505@1|root,COG5505@2|Bacteria,1TSC8@1239|Firmicutes,4HBJU@91061|Bacilli,27CK4@186824|Thermoactinomycetaceae	91061|Bacilli	S	Protein of unknown function (DUF819)	yjcL	-	-	-	-	-	-	-	-	-	-	-	DUF819
k59_896792_1	1087448.Eab7_0494	2.34e-09	59.7	COG2020@1|root,COG2020@2|Bacteria,1VDZ2@1239|Firmicutes,4HKYB@91061|Bacilli	91061|Bacilli	O	Isoprenylcysteine carboxyl methyltransferase (ICMT) family	-	-	-	-	-	-	-	-	-	-	-	-	ICMT,PEMT
k59_1619084_1	1408224.SAMCCGM7_c4743	5.46e-52	182.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,2TSCJ@28211|Alphaproteobacteria,4BARQ@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
k59_952254_1	1214101.BN159_0866	2.24e-61	197.0	COG2220@1|root,COG2220@2|Bacteria,2GMTR@201174|Actinobacteria	201174|Actinobacteria	E	Zn-dependent hydrolases of the beta-lactamase fold	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2,Lactamase_B_3
k59_1119299_1	247156.NFA_50330	5.02e-35	137.0	COG1020@1|root,COG1020@2|Bacteria,2GISR@201174|Actinobacteria,4FUGV@85025|Nocardiaceae	201174|Actinobacteria	Q	Peptide synthetase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
k59_1232616_1	234267.Acid_4270	2.16e-74	249.0	COG4447@1|root,COG4447@2|Bacteria,3Y487@57723|Acidobacteria	57723|Acidobacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_453564_1	926560.KE387023_gene3595	2.81e-25	109.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,1WMBC@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,BTAD,TPR_12
k59_953557_1	1367847.JCM7686_2296	2.77e-157	444.0	COG2801@1|root,COG2801@2|Bacteria,1MVC8@1224|Proteobacteria,2TRX0@28211|Alphaproteobacteria,2PWUE@265|Paracoccus	28211|Alphaproteobacteria	L	HTH-like domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
k59_341890_1	281090.Lxx04940	3.03e-10	65.5	COG1216@1|root,COG1216@2|Bacteria,2GIUN@201174|Actinobacteria,4FNJD@85023|Microbacteriaceae	201174|Actinobacteria	M	Glycosyltransferase like family 2	wbbL	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0045226,GO:0046379,GO:0071704,GO:0071944,GO:1901576	2.4.1.289	ko:K16870	-	-	-	-	ko00000,ko01000,ko01003	-	-	iNJ661.Rv3265c	Glyco_tranf_2_3,Glycos_transf_2
k59_8791_1	562970.Btus_1940	1.92e-23	99.0	COG3598@1|root,COG3598@2|Bacteria,1W6Z7@1239|Firmicutes,4IESD@91061|Bacilli,279ZE@186823|Alicyclobacillaceae	91061|Bacilli	L	Primase C terminal 1 (PriCT-1)	-	-	-	-	-	-	-	-	-	-	-	-	PriCT_1,Prim-Pol
k59_1731892_1	999419.HMPREF1077_00017	1.02e-21	99.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,4NGU2@976|Bacteroidetes,2FPGA@200643|Bacteroidia,22XI5@171551|Porphyromonadaceae	976|Bacteroidetes	M	Tricorn protease homolog	-	-	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
k59_675937_1	1206741.BAFX01000191_gene4470	0.00014	49.3	COG0642@1|root,COG2205@2|Bacteria,2GM17@201174|Actinobacteria,4FV1U@85025|Nocardiaceae	201174|Actinobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K07653	ko02020,map02020	M00460	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
k59_1009456_1	518766.Rmar_1441	1.34e-80	253.0	COG0577@1|root,COG0577@2|Bacteria,4NEBD@976|Bacteroidetes	976|Bacteroidetes	V	ABC-type antimicrobial peptide transport system, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_731630_1	1123278.KB893578_gene1279	9.93e-99	311.0	COG1506@1|root,COG1506@2|Bacteria,4NE60@976|Bacteroidetes,47JEM@768503|Cytophagia	976|Bacteroidetes	E	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
k59_1232656_1	1133849.O3I_037630	2.2e-08	60.8	COG3525@1|root,COG3525@2|Bacteria,2GK90@201174|Actinobacteria,4G5PA@85025|Nocardiaceae	201174|Actinobacteria	G	Glycosyl hydrolase family 20, catalytic domain	-	-	3.2.1.52	ko:K12373	ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142	M00079	R00022,R06004,R11316	RC00049	ko00000,ko00001,ko00002,ko01000,ko03110	-	GH20	-	F5_F8_type_C,Glyco_hydro_20,Glyco_hydro_20b,RicinB_lectin_2,Ricin_B_lectin
k59_1120883_1	1000565.METUNv1_03549	2.28e-62	204.0	COG0116@1|root,COG0116@2|Bacteria,1MUQM@1224|Proteobacteria,2VHMY@28216|Betaproteobacteria,2KV05@206389|Rhodocyclales	206389|Rhodocyclales	L	Belongs to the methyltransferase superfamily	-	-	-	ko:K07444	-	-	-	-	ko00000,ko01000	-	-	-	THUMP,UPF0020
k59_508914_1	420246.GTNG_3020	1.43e-46	156.0	COG0139@1|root,COG0140@1|root,COG0139@2|Bacteria,COG0140@2|Bacteria,1UYNA@1239|Firmicutes,4HA9R@91061|Bacilli,1WFH5@129337|Geobacillus	91061|Bacilli	E	Histidine biosynthesis bifunctional protein HisIE	hisI	-	3.5.4.19,3.6.1.31	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS14110,iYO844.BSU34860	PRA-CH,PRA-PH
k59_508914_2	926569.ANT_23680	4.64e-24	93.6	COG0140@1|root,COG0140@2|Bacteria,2G9QR@200795|Chloroflexi	200795|Chloroflexi	E	Phosphoribosyl-ATP pyrophosphohydrolase	hisE	-	3.6.1.31	ko:K01523	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-PH
k59_175291_1	1123060.JONP01000032_gene1866	1.06e-52	176.0	COG2084@1|root,COG2084@2|Bacteria,1PU4S@1224|Proteobacteria,2TT0X@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid	-	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
k59_175291_2	983917.RGE_02710	2.89e-19	85.5	COG3279@1|root,COG3279@2|Bacteria,1R9Q4@1224|Proteobacteria,2WEES@28216|Betaproteobacteria,1KN7W@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Response regulator of the LytR AlgR family	-	-	-	-	-	-	-	-	-	-	-	-	LytTR,Response_reg
k59_175296_1	1122132.AQYH01000007_gene2207	9.53e-74	229.0	COG0568@1|root,COG0568@2|Bacteria,1MUXA@1224|Proteobacteria,2TUED@28211|Alphaproteobacteria,4BAB8@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	rpoH2	-	-	ko:K03089	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4
k59_898483_2	1173026.Glo7428_1096	2.54e-72	246.0	COG2931@1|root,COG4222@1|root,COG4247@1|root,COG2931@2|Bacteria,COG4222@2|Bacteria,COG4247@2|Bacteria,1G00S@1117|Cyanobacteria	1117|Cyanobacteria	C	PFAM Phytase	-	-	3.1.3.1,3.1.3.8,3.1.4.46	ko:K01083,ko:K01113,ko:K01126	ko00562,ko00564,ko00790,ko01100,ko02020,map00562,map00564,map00790,map01100,map02020	M00126	R01030,R01470,R03371,R04620	RC00017,RC00078,RC00425	ko00000,ko00001,ko00002,ko01000	-	-	-	Calx-beta,DUF4114,Exo_endo_phos,GDPD,HemolysinCabind,PhoD,PhoD_N,Phytase,Phytase-like,SurE
k59_787045_1	1131814.JAFO01000001_gene1673	2.31e-46	161.0	COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,2TT0T@28211|Alphaproteobacteria,3EZNN@335928|Xanthobacteraceae	28211|Alphaproteobacteria	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_1620562_1	671143.DAMO_2317	1.09e-54	184.0	COG0253@1|root,COG0253@2|Bacteria,2NPFA@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	iIT341.HP0566,iLJ478.TM1522	DAP_epimerase
k59_8835_1	886293.Sinac_0521	5.08e-41	153.0	COG1570@1|root,COG1961@1|root,COG1570@2|Bacteria,COG1961@2|Bacteria	2|Bacteria	L	recombinase activity	xseA	-	3.1.11.6	ko:K03601,ko:K13582	ko03430,ko04112,map03430,map04112	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,KfrA_N,Recombinase,Resolvase,Zn_ribbon_recom,tRNA_anti_2
k59_341945_1	864051.BurJ1DRAFT_2686	1.25e-43	147.0	COG2391@1|root,COG2391@2|Bacteria,1N3PQ@1224|Proteobacteria,2VXAQ@28216|Betaproteobacteria,1KP4P@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Sulphur transport	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
k59_1342809_1	502025.Hoch_6550	2.19e-50	180.0	COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,42Q75@68525|delta/epsilon subdivisions,2WMDY@28221|Deltaproteobacteria,2YUG7@29|Myxococcales	28221|Deltaproteobacteria	L	DEAD/H associated	lhr1	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
k59_619975_1	479433.Caci_6918	5.41e-69	243.0	COG2319@1|root,COG2319@2|Bacteria,2GJN3@201174|Actinobacteria	201174|Actinobacteria	F	WD-40 repeat	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,HTH_31,WD40
k59_842274_1	266265.Bxe_C0823	2.8e-103	306.0	COG2171@1|root,COG2171@2|Bacteria,1MYKK@1224|Proteobacteria,2VI88@28216|Betaproteobacteria,1KC1R@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Tetrahydrodipicolinate N-succinyltransferase middle	-	-	2.3.1.117	ko:K00674	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04365	RC00004,RC01136	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep_2,THDPS_M
k59_1064824_1	990285.RGCCGE502_03847	1.87e-29	117.0	COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,2TT2C@28211|Alphaproteobacteria,4B7FN@82115|Rhizobiaceae	28211|Alphaproteobacteria	FP	Exopolyphosphatase	ppx	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
k59_900616_1	1122604.JONR01000011_gene3636	0.000384	49.7	COG0477@1|root,COG0477@2|Bacteria,1MWXZ@1224|Proteobacteria,1RPIM@1236|Gammaproteobacteria,1XC8A@135614|Xanthomonadales	135614|Xanthomonadales	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_10736_1	118161.KB235922_gene575	5.61e-39	149.0	COG3119@1|root,COG3119@2|Bacteria,1G5IZ@1117|Cyanobacteria	1117|Cyanobacteria	P	Arylsulfatase a	-	-	3.1.6.6	ko:K01133	-	-	-	-	ko00000,ko01000	-	-	-	DUF4976,Sulfatase,Sulfatase_C
k59_343833_2	1123288.SOV_2c06550	1.05e-27	116.0	COG0768@1|root,COG0768@2|Bacteria,1TP93@1239|Firmicutes,4H207@909932|Negativicutes	909932|Negativicutes	M	Penicillin-binding protein, transpeptidase domain protein	ftsI	-	3.4.16.4	ko:K03587,ko:K08384	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PASTA,PBP_dimer,Transpeptidase
k59_1622381_1	438753.AZC_2620	4.59e-13	63.9	COG2706@1|root,COG2706@2|Bacteria	2|Bacteria	G	6-phosphogluconolactonase activity	-	-	3.1.1.31	ko:K07404	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Lactonase
k59_1622381_2	268407.PWYN_21245	2.03e-26	107.0	COG0667@1|root,COG0667@2|Bacteria,1TQJC@1239|Firmicutes,4HC0W@91061|Bacilli,26RUI@186822|Paenibacillaceae	91061|Bacilli	C	oxidoreductases (related to aryl-alcohol dehydrogenases)	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_177219_1	309807.SRU_2711	1.39e-43	162.0	COG4232@1|root,COG4233@1|root,COG4232@2|Bacteria,COG4233@2|Bacteria,4NEW6@976|Bacteroidetes,1FJJN@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	CO	Disulphide bond corrector protein DsbC	-	-	1.8.1.8	ko:K04084	-	-	-	-	ko00000,ko01000,ko03110	5.A.1.1	-	-	DsbC,DsbD,Thioredoxin_7
k59_343858_1	69319.XP_008545152.1	7e-07	56.2	KOG3567@1|root,KOG3567@2759|Eukaryota,39XEH@33154|Opisthokonta,3BAVT@33208|Metazoa,3D57J@33213|Bilateria,41Y4J@6656|Arthropoda,3SIR3@50557|Insecta,46GWK@7399|Hymenoptera	33208|Metazoa	O	NHL repeat	-	GO:0003674,GO:0003824,GO:0004598,GO:0005575,GO:0005576,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016840,GO:0016842,GO:0044237,GO:0140096	4.3.2.5	ko:K18200	-	-	-	-	ko00000,ko01000	-	-	-	NHL
k59_678092_1	1177154.Y5S_03767	1.59e-08	60.8	COG0672@1|root,COG2010@1|root,COG0672@2|Bacteria,COG2010@2|Bacteria,1MXHM@1224|Proteobacteria,1RMWB@1236|Gammaproteobacteria,1XKJR@135619|Oceanospirillales	135619|Oceanospirillales	P	COG2010 Cytochrome c, mono- and diheme variants	-	-	-	ko:K07243	-	-	-	-	ko00000,ko02000	2.A.108.1,2.A.108.2	-	-	Cytochrome_CBB3,FTR1
k59_177226_1	749222.Nitsa_0867	6.21e-124	392.0	COG0474@1|root,COG0475@1|root,COG0474@2|Bacteria,COG0475@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2YNQF@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	P	COG0474 Cation transport ATPase	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3,Na_H_Exchanger
k59_399804_2	1282876.BAOK01000001_gene1282	4.09e-24	101.0	COG2041@1|root,COG2041@2|Bacteria,1MUW0@1224|Proteobacteria,2TS40@28211|Alphaproteobacteria,4BP7Q@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide	msrP	-	-	ko:K07147	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_molyb
k59_1622403_1	391600.ABRU01000034_gene2907	5.87e-20	89.0	COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,2TR4T@28211|Alphaproteobacteria,2KFZC@204458|Caulobacterales	204458|Caulobacterales	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
k59_1622403_2	266834.SMc02063	6.92e-38	135.0	COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,2TQXZ@28211|Alphaproteobacteria,4B91G@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
k59_900662_2	999549.KI421514_gene424	3.03e-33	125.0	COG0582@1|root,COG0582@2|Bacteria,1NWGS@1224|Proteobacteria,2TQWR@28211|Alphaproteobacteria,28291@191028|Leisingera	28211|Alphaproteobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
k59_1678357_1	34007.IT40_21690	1.65e-51	173.0	COG0600@1|root,COG0600@2|Bacteria,1PC26@1224|Proteobacteria,2TV2Y@28211|Alphaproteobacteria,2PYGV@265|Paracoccus	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
k59_233213_1	105420.BBPO01000025_gene7106	9.08e-57	191.0	COG4941@1|root,COG4941@2|Bacteria,2GJ36@201174|Actinobacteria,2NEFM@228398|Streptacidiphilus	201174|Actinobacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_789192_1	1123371.ATXH01000008_gene232	6.27e-15	73.2	COG0212@1|root,COG0212@2|Bacteria,2GIAY@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	H	5-formyltetrahydrofolate cyclo-ligase family	-	-	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
k59_789192_2	471855.Shel_11930	1.5e-38	141.0	COG0301@1|root,COG0301@2|Bacteria,2GMFY@201174|Actinobacteria,4CU8T@84998|Coriobacteriia	84998|Coriobacteriia	H	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	thiI	-	2.8.1.4	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07461	-	ko00000,ko00001,ko01000,ko03016	-	-	-	THUMP,ThiI
k59_177246_1	861299.J421_4128	9.05e-60	201.0	COG0366@1|root,COG0366@2|Bacteria	2|Bacteria	G	hydrolase activity, hydrolyzing O-glycosyl compounds	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	iLJ478.TM1840	Alpha-amylase,DUF1945,DUF3459
k59_900674_1	237368.SCABRO_03425	1.3e-40	144.0	COG0463@1|root,COG0463@2|Bacteria,2IZV0@203682|Planctomycetes	203682|Planctomycetes	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_1678368_1	1202962.KB907151_gene934	2.23e-53	188.0	COG0834@1|root,COG4623@1|root,COG0834@2|Bacteria,COG4623@2|Bacteria,1MWDS@1224|Proteobacteria,1RM8W@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella	-	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944	-	ko:K18691	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	SBP_bac_3,SLT
k59_1400482_1	1521187.JPIM01000010_gene2149	5.81e-55	186.0	COG2379@1|root,COG2379@2|Bacteria,2G5RZ@200795|Chloroflexi,374XG@32061|Chloroflexia	32061|Chloroflexia	C	PFAM MOFRL domain protein	-	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
k59_955637_2	1283299.AUKG01000003_gene598	7.21e-24	93.6	COG1522@1|root,COG1522@2|Bacteria,2IQD4@201174|Actinobacteria,4CQQR@84995|Rubrobacteria	84995|Rubrobacteria	K	Lrp/AsnC ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
k59_955637_3	338963.Pcar_2044	2.56e-38	135.0	COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,42MA4@68525|delta/epsilon subdivisions,2WIPU@28221|Deltaproteobacteria,43S7P@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	Enoyl-(Acyl carrier protein) reductase	fabI	-	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_121547_1	1121904.ARBP01000008_gene3319	7.43e-70	233.0	COG0457@1|root,COG0457@2|Bacteria,4NH2F@976|Bacteroidetes,47N0J@768503|Cytophagia	976|Bacteroidetes	S	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
k59_177261_1	313606.M23134_08281	1.31e-08	61.2	COG2374@1|root,COG2911@1|root,COG2931@1|root,COG3291@1|root,COG3391@1|root,COG3897@1|root,COG2374@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3291@2|Bacteria,COG3391@2|Bacteria,COG3897@2|Bacteria,4PMEU@976|Bacteroidetes,47RH2@768503|Cytophagia	976|Bacteroidetes	G	Concanavalin A-like lectin/glucanases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	BNR_assoc_N,Laminin_G_3
k59_955644_1	767817.Desgi_3840	1.88e-81	249.0	COG1908@1|root,COG2878@1|root,COG1908@2|Bacteria,COG2878@2|Bacteria,1V7I6@1239|Firmicutes,24JV2@186801|Clostridia,261SC@186807|Peptococcaceae	186801|Clostridia	C	PFAM methyl-viologen-reducing hydrogenase delta subunit	-	-	1.8.98.5,1.8.98.6	ko:K14127	ko00680,map00680	-	R00019,R11943,R11944	RC00011	ko00000,ko00001,ko01000	-	-	-	Fer4,FlpD,HTH_5
k59_121554_1	768066.HELO_3200	1.11e-37	130.0	COG3795@1|root,COG3795@2|Bacteria,1RK95@1224|Proteobacteria,1S6H7@1236|Gammaproteobacteria,1XS9G@135619|Oceanospirillales	135619|Oceanospirillales	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
k59_121554_2	926550.CLDAP_27260	1.33e-19	85.1	COG5516@1|root,COG5516@2|Bacteria,2G7GV@200795|Chloroflexi	200795|Chloroflexi	S	Putative stress-induced transcription regulator	-	-	-	-	-	-	-	-	-	-	-	-	ABATE,zf-CGNR
k59_510890_1	309801.trd_0155	8.37e-99	291.0	COG1150@1|root,COG1150@2|Bacteria	2|Bacteria	C	4Fe-4S dicluster domain	dld	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390,ko:K18930	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_7,Fer4_8
k59_510896_1	243231.GSU2599	2.47e-78	244.0	COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,42NNQ@68525|delta/epsilon subdivisions,2WM2H@28221|Deltaproteobacteria,43TYM@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_844227_1	1479623.JHEL01000015_gene638	1.79e-46	157.0	COG0740@1|root,COG0740@2|Bacteria,2GKNK@201174|Actinobacteria,4FKH7@85023|Microbacteriaceae	201174|Actinobacteria	OU	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
k59_789242_1	994479.GL877880_gene3961	4.18e-05	47.0	COG1678@1|root,COG1678@2|Bacteria,2GNRA@201174|Actinobacteria,4DZ3Q@85010|Pseudonocardiales	201174|Actinobacteria	K	Belongs to the UPF0301 (AlgH) family	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
k59_789242_2	1158182.KB905021_gene536	9.98e-19	77.8	2E4KB@1|root,32ZFA@2|Bacteria,1N6R9@1224|Proteobacteria,1SFP8@1236|Gammaproteobacteria,1WZH8@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_789242_3	1249627.D779_0180	2.79e-37	130.0	COG1047@1|root,COG1047@2|Bacteria,1REQ1@1224|Proteobacteria,1S2MS@1236|Gammaproteobacteria,1WY6J@135613|Chromatiales	135613|Chromatiales	O	Peptidyl-prolyl cis-trans	-	-	5.2.1.8	ko:K03775	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	-
k59_455699_1	1519464.HY22_00080	3.48e-09	58.2	COG0552@1|root,COG0552@2|Bacteria,1FDHH@1090|Chlorobi	1090|Chlorobi	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
k59_455699_2	1382359.JIAL01000001_gene2034	8.65e-45	167.0	COG1196@1|root,COG1196@2|Bacteria,3Y2W1@57723|Acidobacteria,2JHJF@204432|Acidobacteriia	204432|Acidobacteriia	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
k59_510902_1	382464.ABSI01000020_gene276	1.55e-54	184.0	COG0598@1|root,COG0598@2|Bacteria,46VYH@74201|Verrucomicrobia,2IU92@203494|Verrucomicrobiae	203494|Verrucomicrobiae	P	CorA-like Mg2+ transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	CorA
k59_177297_1	1121373.KB903626_gene3321	2.5e-13	75.9	COG0318@1|root,COG0318@2|Bacteria,4NFPF@976|Bacteroidetes,47NTH@768503|Cytophagia	976|Bacteroidetes	IQ	AMP-binding enzyme C-terminal domain	-	-	6.2.1.3	ko:K01897,ko:K18660	ko00061,ko00071,ko00280,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map00280,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280,R03383	RC00004,RC00014,RC00137	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
k59_1400541_2	1071379.XP_004181637.1	7.75e-06	48.9	COG0633@1|root,KOG3309@2759|Eukaryota,3A01K@33154|Opisthokonta,3P2DF@4751|Fungi,3QV28@4890|Ascomycota,3RUH2@4891|Saccharomycetes,3S13Z@4893|Saccharomycetaceae	4751|Fungi	C	to Saccharomyces cerevisiae YAH1 (YPL252C)	YAH1	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006725,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006778,GO:0006779,GO:0006783,GO:0006784,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016043,GO:0016226,GO:0016491,GO:0016651,GO:0016653,GO:0018130,GO:0019438,GO:0022607,GO:0031163,GO:0031974,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042180,GO:0042181,GO:0042440,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044085,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046148,GO:0046160,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0070013,GO:0071704,GO:0071840,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901661,GO:1901663	-	ko:K22071	-	-	-	-	ko00000,ko03029	-	-	-	Fer2
k59_900739_1	1205680.CAKO01000002_gene3059	2.49e-78	246.0	COG1304@1|root,COG1304@2|Bacteria,1MUEZ@1224|Proteobacteria,2TQNW@28211|Alphaproteobacteria,2JSA1@204441|Rhodospirillales	204441|Rhodospirillales	C	Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain	-	-	-	-	-	-	-	-	-	-	-	-	FMN_dh
k59_621944_1	1123023.JIAI01000002_gene4749	1.81e-15	74.7	COG1280@1|root,COG1280@2|Bacteria,2HRJJ@201174|Actinobacteria,4EB82@85010|Pseudonocardiales	201174|Actinobacteria	E	LysE type translocator	-	-	-	-	-	-	-	-	-	-	-	-	LysE
k59_621944_2	438753.AZC_4377	1.31e-15	78.2	COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,2U0KX@28211|Alphaproteobacteria,3EZV2@335928|Xanthobacteraceae	28211|Alphaproteobacteria	F	Amidohydrolase family	-	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
k59_510920_1	316067.Geob_1727	4.99e-112	339.0	COG1164@1|root,COG1164@2|Bacteria	2|Bacteria	E	metalloendopeptidase activity	pepF	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
k59_1622496_1	1165096.ARWF01000001_gene1557	0.000115	46.6	COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,2VI2H@28216|Betaproteobacteria,2KNDY@206350|Nitrosomonadales	206350|Nitrosomonadales	U	Sec-independent protein translocase protein (TatC)	-	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
k59_900762_2	749927.AMED_5060	1.13e-12	71.6	COG4249@1|root,COG4249@2|Bacteria	2|Bacteria	S	B-1 B cell differentiation	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,GUN4,KTSC,Peptidase_C13,Peptidase_C14
k59_566420_1	460265.Mnod_6197	9.66e-69	218.0	COG0604@1|root,COG0604@2|Bacteria,1R8NX@1224|Proteobacteria,2TUG0@28211|Alphaproteobacteria,1JYZZ@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	PFAM Alcohol dehydrogenase zinc-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
k59_955702_1	671143.DAMO_0544	4.83e-43	143.0	COG0091@1|root,COG0091@2|Bacteria,2NPNW@2323|unclassified Bacteria	2|Bacteria	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005844,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042788,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
k59_955702_2	671143.DAMO_0543	5.03e-43	142.0	COG0185@1|root,COG0185@2|Bacteria,2NPIV@2323|unclassified Bacteria	2|Bacteria	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
k59_1344814_2	485913.Krac_7606	1.02e-111	333.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,2G9RC@200795|Chloroflexi	200795|Chloroflexi	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
k59_233322_1	234267.Acid_0605	1.28e-43	162.0	COG2366@1|root,COG2366@2|Bacteria,3Y38M@57723|Acidobacteria	57723|Acidobacteria	S	Penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
k59_566430_1	706587.Desti_3722	1.13e-59	199.0	COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,42MUW@68525|delta/epsilon subdivisions,2WIXI@28221|Deltaproteobacteria,2MQWA@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
k59_121633_1	1123060.JONP01000004_gene716	8.59e-89	268.0	COG1024@1|root,COG1024@2|Bacteria,1MXHV@1224|Proteobacteria,2TTEG@28211|Alphaproteobacteria,2JQRS@204441|Rhodospirillales	204441|Rhodospirillales	I	COG1024 Enoyl-CoA hydratase carnithine racemase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
k59_1014037_1	195250.CM001776_gene2865	1.03e-74	234.0	COG3385@1|root,COG3385@2|Bacteria,1G2YX@1117|Cyanobacteria	1117|Cyanobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
k59_1180441_1	479434.Sthe_0301	9.86e-76	246.0	COG1007@1|root,COG1007@2|Bacteria,2G5ZK@200795|Chloroflexi,27XVQ@189775|Thermomicrobia	189775|Thermomicrobia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_957941_1	148960.XP_006959952.1	1.22e-40	146.0	COG2930@1|root,KOG1843@2759|Eukaryota,38FCU@33154|Opisthokonta,3NWAM@4751|Fungi,3UXUS@5204|Basidiomycota	4751|Fungi	S	duf500-domain-containing protein	-	GO:0001726,GO:0003674,GO:0003779,GO:0005488,GO:0005515,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005829,GO:0005856,GO:0005886,GO:0005933,GO:0005935,GO:0005938,GO:0006810,GO:0006897,GO:0006996,GO:0007010,GO:0007015,GO:0008092,GO:0008150,GO:0008289,GO:0009987,GO:0015629,GO:0016020,GO:0016043,GO:0016192,GO:0022607,GO:0030029,GO:0030036,GO:0030427,GO:0030479,GO:0030863,GO:0030864,GO:0031252,GO:0031253,GO:0031256,GO:0031344,GO:0032587,GO:0035091,GO:0042995,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0044085,GO:0044087,GO:0044422,GO:0044424,GO:0044425,GO:0044430,GO:0044444,GO:0044446,GO:0044448,GO:0044459,GO:0044463,GO:0044464,GO:0044877,GO:0050789,GO:0050794,GO:0051015,GO:0051017,GO:0051128,GO:0051179,GO:0051234,GO:0051641,GO:0051666,GO:0060491,GO:0061572,GO:0061645,GO:0065007,GO:0071840,GO:0071944,GO:0097435,GO:0098590,GO:0098657,GO:0099568,GO:0120025,GO:0120032,GO:0120035,GO:0120038,GO:1900027	-	ko:K20523	-	-	-	-	ko00000,ko04131	-	-	-	SH3_1,SH3_2,Ysc84
k59_680556_1	247490.KSU1_D0387	5.45e-25	102.0	COG0499@1|root,COG0499@2|Bacteria,2IXKQ@203682|Planctomycetes	203682|Planctomycetes	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
k59_680556_2	1122939.ATUD01000020_gene2153	4.39e-23	99.0	COG2222@1|root,COG2222@2|Bacteria,2IN5A@201174|Actinobacteria,4CP71@84995|Rubrobacteria	84995|Rubrobacteria	M	Bacterial phospho-glucose isomerase C-terminal SIS domain	-	-	5.3.1.8,5.3.1.9	ko:K15916	ko00010,ko00030,ko00051,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R01819,R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	bact-PGI_C
k59_1069172_1	258052.JNYV01000004_gene4031	0.000338	44.7	COG2244@1|root,COG2244@2|Bacteria,2H55P@201174|Actinobacteria	201174|Actinobacteria	M	Polysaccharide biosynthesis protein	-	-	-	ko:K03328,ko:K16695	-	-	-	-	ko00000,ko02000	2.A.66.2,2.A.66.2.7	-	-	Polysacc_synt_3,Polysacc_synt_C
k59_13115_1	861299.J421_0886	2.02e-25	103.0	COG1595@1|root,COG1595@2|Bacteria,1ZUWT@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
k59_1458775_1	1336249.JADW01000027_gene2621	3.01e-71	221.0	COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,2TS16@28211|Alphaproteobacteria,4BB8M@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	IstB-like ATP binding protein	MA20_10895	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
k59_1680697_1	1464048.JNZS01000052_gene2388	1.3e-30	122.0	COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria,4DBB6@85008|Micromonosporales	201174|Actinobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_568572_1	344747.PM8797T_25576	8.68e-44	162.0	COG0841@1|root,COG0841@2|Bacteria,2IY0K@203682|Planctomycetes	203682|Planctomycetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_1513961_2	553385.JEMF01000038_gene587	7.35e-26	101.0	COG1970@1|root,COG1970@2|Bacteria,1RHG8@1224|Proteobacteria,1S3PD@1236|Gammaproteobacteria,1XKKT@135619|Oceanospirillales	135619|Oceanospirillales	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
k59_1680708_1	345073.VC395_0158	2.31e-28	110.0	COG2119@1|root,COG2119@2|Bacteria,1RDDV@1224|Proteobacteria,1S3QT@1236|Gammaproteobacteria,1XSNJ@135623|Vibrionales	135623|Vibrionales	S	Uncharacterized protein family UPF0016	-	-	-	-	-	-	-	-	-	-	-	-	UPF0016
k59_1569648_1	180332.JTGN01000012_gene379	1.06e-08	57.4	COG0682@1|root,COG0682@2|Bacteria,1TPAK@1239|Firmicutes,24BK7@186801|Clostridia	186801|Clostridia	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
k59_1569648_2	1379270.AUXF01000001_gene2810	2.71e-10	62.0	COG3794@1|root,COG3794@2|Bacteria,1ZTXJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
k59_1125485_1	1094508.Tsac_2071	9.48e-05	47.8	COG1466@1|root,COG1466@2|Bacteria,1TRM0@1239|Firmicutes,24ASN@186801|Clostridia,42G45@68295|Thermoanaerobacterales	186801|Clostridia	L	TIGRFAM DNA polymerase III, delta subunit	holA	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
k59_903070_1	391625.PPSIR1_06983	5.69e-71	228.0	COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,42KZH@68525|delta/epsilon subdivisions,2WIRM@28221|Deltaproteobacteria,2YUK3@29|Myxococcales	28221|Deltaproteobacteria	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
k59_179495_1	1459636.NTE_03306	3.35e-23	92.0	COG1958@1|root,arCOG00999@2157|Archaea	2157|Archaea	K	PFAM Like-Sm ribonucleoprotein, core	-	-	-	-	-	-	-	-	-	-	-	-	LSM,Lsm_C,SM-ATX
k59_179495_2	269797.Mbar_A1088	5.94e-26	108.0	COG0343@1|root,arCOG00989@2157|Archaea,2XTFH@28890|Euryarchaeota,2N9F2@224756|Methanomicrobia	224756|Methanomicrobia	J	Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs	tgtA	-	2.4.2.48	ko:K18779	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TGT
k59_1014088_1	1454004.AW11_03099	3.85e-09	53.9	2DNU9@1|root,32Z5Z@2|Bacteria,1N93E@1224|Proteobacteria,2VWE8@28216|Betaproteobacteria	28216|Betaproteobacteria	S	MerR HTH family regulatory protein	-	-	-	ko:K18997	-	-	-	-	ko00000,ko03036	-	-	-	MerR_2
k59_1014088_2	640081.Dsui_1121	1.91e-103	308.0	COG0568@1|root,COG0568@2|Bacteria,1MVWR@1224|Proteobacteria,2VI91@28216|Betaproteobacteria,2KUT2@206389|Rhodocyclales	206389|Rhodocyclales	K	RNA polymerase sigma	rpoH	-	-	ko:K03089	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r4
k59_791624_1	1288494.EBAPG3_13420	1.35e-56	181.0	COG1666@1|root,COG1666@2|Bacteria,1RDTF@1224|Proteobacteria,2VPZU@28216|Betaproteobacteria,3731D@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Belongs to the UPF0234 family	yajQ	-	-	ko:K09767	-	-	-	-	ko00000	-	-	-	DUF520
k59_1402825_1	234267.Acid_2214	8.74e-40	150.0	COG0577@1|root,COG0577@2|Bacteria,3Y6B8@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_1069232_1	103733.JNYO01000021_gene6862	2.97e-81	261.0	COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria,4DXAG@85010|Pseudonocardiales	201174|Actinobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_1736237_1	397288.C806_00567	1.37e-33	133.0	COG2208@1|root,COG2208@2|Bacteria,1TQY5@1239|Firmicutes,249WB@186801|Clostridia,27JID@186928|unclassified Lachnospiraceae	186801|Clostridia	KT	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	5TM-5TMR_LYT,HAMP,HATPase_c_2,SpoIIE,dCache_1
k59_1407712_1	391735.Veis_4821	4.85e-11	63.5	COG0559@1|root,COG0559@2|Bacteria,1MVND@1224|Proteobacteria,2VK6C@28216|Betaproteobacteria,4AB0U@80864|Comamonadaceae	28216|Betaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_128113_1	926560.KE387023_gene3655	7.08e-44	155.0	COG1609@1|root,COG1609@2|Bacteria,1WMBZ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	K	PFAM Bacterial regulatory proteins, lacI family	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
k59_240263_1	589924.Ferp_1614	2.17e-17	83.6	arCOG05636@1|root,arCOG05636@2157|Archaea,2Y231@28890|Euryarchaeota,246ID@183980|Archaeoglobi	183980|Archaeoglobi	C	Prokaryotic cytochrome b561	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
k59_1685625_1	1569209.BBPH01000120_gene2632	3.99e-28	105.0	COG0268@1|root,COG0268@2|Bacteria,1MZ94@1224|Proteobacteria,2UC42@28211|Alphaproteobacteria,2PXKH@265|Paracoccus	28211|Alphaproteobacteria	J	Binds directly to 16S ribosomal RNA	rpsT	-	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
k59_1019101_1	314278.NB231_08365	2.56e-52	189.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,Dimer_Tnp_Tn5,Tnp_DNA_bind
k59_850838_1	215803.DB30_8370	6.13e-34	134.0	COG0577@1|root,COG0577@2|Bacteria,1NREW@1224|Proteobacteria,433ZM@68525|delta/epsilon subdivisions,2X48T@28221|Deltaproteobacteria,2YYI5@29|Myxococcales	28221|Deltaproteobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_685607_1	697282.Mettu_3064	5.27e-56	190.0	COG0156@1|root,COG0156@2|Bacteria,1R0M1@1224|Proteobacteria,1S12P@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
k59_740802_1	313612.L8106_28371	2.3e-15	73.2	COG0355@1|root,COG0355@2|Bacteria,1G5R3@1117|Cyanobacteria,1HB5F@1150|Oscillatoriales	1117|Cyanobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045259,GO:0045260,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE,ATP-synt_DE_N
k59_740802_2	998088.B565_4005	8.9e-19	85.5	COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,1RN6U@1236|Gammaproteobacteria,1Y3DS@135624|Aeromonadales	135624|Aeromonadales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_1242338_1	631454.N177_0906	1.42e-59	209.0	COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,2TS89@28211|Alphaproteobacteria,1JN4R@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	Bacterial NAD-glutamate dehydrogenase	gdhB	GO:0003674,GO:0003824,GO:0004352,GO:0004353,GO:0008150,GO:0008152,GO:0016491,GO:0016638,GO:0016639,GO:0055114	1.4.1.2	ko:K15371	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	-	R00243	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	Bac_GDH
k59_1629283_1	1444306.JFZC01000036_gene2965	3.53e-26	111.0	COG0793@1|root,COG0793@2|Bacteria,1TPBI@1239|Firmicutes,4HAKE@91061|Bacilli,26NIB@186821|Sporolactobacillaceae	91061|Bacilli	M	tail specific protease	ctpB	GO:0003674,GO:0003824,GO:0004175,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006508,GO:0006518,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008233,GO:0009653,GO:0009987,GO:0016787,GO:0019538,GO:0023052,GO:0030154,GO:0030288,GO:0030313,GO:0030435,GO:0031975,GO:0032502,GO:0033218,GO:0034641,GO:0042277,GO:0042597,GO:0042802,GO:0042803,GO:0043170,GO:0043603,GO:0043900,GO:0043902,GO:0043934,GO:0044237,GO:0044238,GO:0044464,GO:0046983,GO:0048518,GO:0048522,GO:0048646,GO:0048856,GO:0048869,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070011,GO:0071704,GO:0140096,GO:1900190,GO:1900192,GO:1901564	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,PG_binding_1,Peptidase_S41
k59_1130364_1	645512.GCWU000246_01513	2.58e-17	84.7	COG1473@1|root,COG1473@2|Bacteria,3TABQ@508458|Synergistetes	508458|Synergistetes	S	amidohydrolase	-	-	-	ko:K01436	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
k59_350760_1	1123504.JQKD01000012_gene1254	1.04e-22	95.9	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VN32@28216|Betaproteobacteria,4ADTG@80864|Comamonadaceae	28216|Betaproteobacteria	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_350760_2	1123504.JQKD01000012_gene1284	2.89e-60	196.0	COG0119@1|root,COG0119@2|Bacteria,1MUMX@1224|Proteobacteria,2VM5F@28216|Betaproteobacteria,4ABQW@80864|Comamonadaceae	28216|Betaproteobacteria	E	HMGL-like	-	-	-	-	-	-	-	-	-	-	-	-	HMGL-like
k59_1629296_1	411467.BACCAP_01138	1.4e-30	115.0	COG0274@1|root,COG0274@2|Bacteria,1TPAJ@1239|Firmicutes,249XB@186801|Clostridia,267Y0@186813|unclassified Clostridiales	186801|Clostridia	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	-	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
k59_1185246_1	479434.Sthe_2889	7.88e-30	120.0	COG0145@1|root,COG0145@2|Bacteria,2G5KZ@200795|Chloroflexi,27XUM@189775|Thermomicrobia	2|Bacteria	EQ	Hydantoinaseoxoprolinase domain protein	oplaH	-	3.5.2.14,3.5.2.9	ko:K01469,ko:K01473	ko00330,ko00480,ko01100,map00330,map00480,map01100	-	R00251,R03187	RC00553,RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A,Hydantoinase_B
k59_1130380_1	543632.JOJL01000034_gene5128	4.94e-45	163.0	COG1249@1|root,COG1249@2|Bacteria,2GPG1@201174|Actinobacteria,4DA3V@85008|Micromonosporales	201174|Actinobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	sthA	-	1.6.1.1	ko:K00322	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_184247_1	1121468.AUBR01000045_gene1801	5.57e-37	134.0	COG3643@1|root,COG3643@2|Bacteria,1TP5T@1239|Firmicutes,24905@186801|Clostridia,42EU0@68295|Thermoanaerobacterales	186801|Clostridia	E	PFAM Formiminotransferase	ftcD	-	2.1.2.5,4.3.1.4	ko:K00603,ko:K01746	ko00340,ko00670,ko01100,map00340,map00670,map01100	-	R02287,R02302,R03189	RC00165,RC00221,RC00223,RC00688,RC00870	ko00000,ko00001,ko01000	-	-	-	FTCD,FTCD_N
k59_1073858_1	1120963.KB894494_gene3419	5e-07	57.4	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,1MX41@1224|Proteobacteria,1RP38@1236|Gammaproteobacteria,2Q0BE@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	M	Tricorn protease homolog	-	-	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
k59_518308_1	1396858.Q666_15445	4.46e-33	120.0	COG1664@1|root,COG1664@2|Bacteria,1PDPX@1224|Proteobacteria,1S9XY@1236|Gammaproteobacteria,46885@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	COG1664 Integral membrane protein CcmA involved in cell shape determination	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
k59_240333_1	1397284.AYMN01000089_gene3317	4.83e-45	165.0	COG0493@1|root,COG1142@1|root,COG0493@2|Bacteria,COG1142@2|Bacteria,1MU2H@1224|Proteobacteria,1RMY7@1236|Gammaproteobacteria,400Y8@613|Serratia	1236|Gammaproteobacteria	C	in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic)	gltD	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
k59_850899_1	1121396.KB892910_gene4167	2.3e-14	74.7	COG3168@1|root,COG3168@2|Bacteria,1N39F@1224|Proteobacteria,42U30@68525|delta/epsilon subdivisions,2WQFA@28221|Deltaproteobacteria,2MKRW@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	Pilus assembly protein, PilP	-	-	-	ko:K02665	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilP
k59_1242395_2	196162.Noca_1377	1.79e-11	63.2	COG1764@1|root,COG1764@2|Bacteria,2IFFB@201174|Actinobacteria,4DRBU@85009|Propionibacteriales	201174|Actinobacteria	O	OsmC-like protein	osmC	-	-	ko:K04063	-	-	-	-	ko00000	-	-	-	OsmC
k59_796424_1	744979.R2A130_3537	7.53e-11	62.8	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	L-carnitine dehydratase bile acid-inducible protein F	MA20_43260	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
k59_796424_2	1411123.JQNH01000001_gene2071	2.03e-61	197.0	COG1024@1|root,COG1024@2|Bacteria,1MXBB@1224|Proteobacteria,2TU4V@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.1.1.41,4.2.1.17	ko:K01692,ko:K11264	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R00923,R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00097,RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
k59_73300_1	485913.Krac_9680	9.52e-57	189.0	COG1595@1|root,COG1595@2|Bacteria,2G6PJ@200795|Chloroflexi	200795|Chloroflexi	K	PFAM sigma-70 region 2 domain protein	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2,SnoaL_2
k59_184275_1	765911.Thivi_0478	1.86e-82	253.0	COG3039@1|root,COG3039@2|Bacteria,1N88K@1224|Proteobacteria	1224|Proteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_3
k59_1685720_1	314231.FP2506_16124	2.12e-05	46.2	COG0848@1|root,COG0848@2|Bacteria,1NB5E@1224|Proteobacteria,2UFGD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	U	biopolymer transport protein ExbD TolR	-	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
k59_73308_1	1122226.AUHX01000002_gene1095	2.91e-15	76.6	COG2755@1|root,COG2755@2|Bacteria,4NGTK@976|Bacteroidetes,1HY1A@117743|Flavobacteriia	976|Bacteroidetes	E	G-D-S-L family lipolytic protein	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL
k59_1518726_2	1485543.JMME01000017_gene2270	6.89e-16	77.4	COG2020@1|root,COG2020@2|Bacteria	2|Bacteria	O	methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
k59_184290_1	1206725.BAFU01000052_gene1571	7.97e-12	71.6	COG1232@1|root,COG3349@1|root,COG1232@2|Bacteria,COG3349@2|Bacteria,2IAFV@201174|Actinobacteria,4FUEJ@85025|Nocardiaceae	201174|Actinobacteria	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
k59_573185_1	504832.OCAR_7524	7.29e-134	389.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TRS8@28211|Alphaproteobacteria,3JS1M@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	nikB	-	-	ko:K02033,ko:K15585	ko02010,ko02024,map02010,map02024	M00239,M00440	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_1685731_1	85982.XP_007316759.1	3.14e-08	59.3	COG0170@1|root,KOG4453@2759|Eukaryota,38F0C@33154|Opisthokonta,3NXUY@4751|Fungi,3V0PJ@5204|Basidiomycota,226X6@155619|Agaricomycetes	4751|Fungi	I	Phosphatidate cytidylyltransferase	DGK1	GO:0003674,GO:0003824,GO:0004143,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0006629,GO:0006644,GO:0006650,GO:0006654,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0012505,GO:0016020,GO:0016021,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019637,GO:0030176,GO:0031224,GO:0031227,GO:0031984,GO:0042175,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0045017,GO:0046473,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:0098827,GO:1901576	2.7.1.174	ko:K16368	ko00564,ko01100,ko01110,map00564,map01100,map01110	-	R09944	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	CTP_transf_1
k59_1185305_2	717774.Marme_0517	4.32e-125	363.0	COG0266@1|root,COG0266@2|Bacteria,1MVM5@1224|Proteobacteria,1RP3J@1236|Gammaproteobacteria,1XH8W@135619|Oceanospirillales	135619|Oceanospirillales	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
k59_73334_1	1379270.AUXF01000005_gene682	7.43e-47	159.0	COG0275@1|root,COG0275@2|Bacteria,1ZT4V@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
k59_350851_2	634956.Geoth_2001	1.72e-19	90.9	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1V41H@1239|Firmicutes,4HH52@91061|Bacilli,1WEBA@129337|Geobacillus	91061|Bacilli	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_29,HTH_33
k59_518374_1	1231391.AMZF01000063_gene1103	9.91e-32	118.0	COG0235@1|root,COG0235@2|Bacteria,1MW7B@1224|Proteobacteria,2VQBC@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Class II aldolase adducin family protein	fucA	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
k59_518374_2	1245469.S58_17900	4.81e-13	69.3	COG0235@1|root,COG0235@2|Bacteria,1RB5Z@1224|Proteobacteria,2U0PK@28211|Alphaproteobacteria,3JVBP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II
k59_1741138_1	1122138.AQUZ01000042_gene3362	4.78e-27	110.0	COG0494@1|root,COG0494@2|Bacteria,2GN6D@201174|Actinobacteria,4DQHA@85009|Propionibacteriales	201174|Actinobacteria	L	NUDIX hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
k59_1242478_1	926569.ANT_04370	5.22e-116	351.0	COG0187@1|root,COG0187@2|Bacteria,2G67C@200795|Chloroflexi	200795|Chloroflexi	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_1407884_1	1123320.KB889574_gene5606	4.18e-06	49.7	COG1414@1|root,COG1414@2|Bacteria,2GM23@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	ko:K13641	-	-	-	-	ko00000,ko03000	-	-	-	HTH_IclR,IclR
k59_1407884_2	1243664.CAVL020000001_gene4817	6.02e-12	72.0	COG0491@1|root,COG0491@2|Bacteria,1TRED@1239|Firmicutes,4HAP2@91061|Bacilli,1ZAYX@1386|Bacillus	91061|Bacilli	S	COG0491 Zn-dependent hydrolases, including glyoxylases	ytnP	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_463512_1	1232410.KI421418_gene2432	1.24e-101	324.0	COG0243@1|root,COG1104@1|root,COG0243@2|Bacteria,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,43CDJ@68525|delta/epsilon subdivisions,2X7PE@28221|Deltaproteobacteria,43TE0@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Aminotransferase class-V	-	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5,Molybdopterin,Molydop_binding
k59_573233_1	1231391.AMZF01000118_gene3333	1.37e-56	181.0	COG2318@1|root,COG2318@2|Bacteria,1RHRP@1224|Proteobacteria,2VT04@28216|Betaproteobacteria	28216|Betaproteobacteria	S	PFAM DinB family protein	-	-	-	-	-	-	-	-	-	-	-	-	DinB
k59_1244711_1	1123269.NX02_22340	8.25e-51	180.0	COG1506@1|root,COG1506@2|Bacteria,1MUJ3@1224|Proteobacteria,2TUZZ@28211|Alphaproteobacteria,2K37J@204457|Sphingomonadales	204457|Sphingomonadales	E	X-Pro dipeptidyl-peptidase (S15 family)	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
k59_298004_1	631454.N177_3581	5.56e-66	221.0	COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,2TRBP@28211|Alphaproteobacteria,1JNNA@119043|Rhodobiaceae	28211|Alphaproteobacteria	P	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
k59_1520836_1	861299.J421_0563	7.63e-97	306.0	COG1472@1|root,COG1472@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 3 family	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C,PA14
k59_20157_1	1096546.WYO_5544	2.37e-80	246.0	COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,1JTSW@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve,rve_3
k59_1409977_1	1217718.ALOU01000020_gene2166	1.26e-108	324.0	COG2267@1|root,COG2267@2|Bacteria,1QTAP@1224|Proteobacteria,2VMEV@28216|Betaproteobacteria,1KIFR@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
k59_798559_1	290397.Adeh_2406	1.23e-28	119.0	COG0493@1|root,COG1145@1|root,COG0493@2|Bacteria,COG1145@2|Bacteria,1MU2H@1224|Proteobacteria,42MGY@68525|delta/epsilon subdivisions,2WKB4@28221|Deltaproteobacteria,2YTUD@29|Myxococcales	28221|Deltaproteobacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4,Fer4_20,Pyr_redox_2
k59_910539_1	1122132.AQYH01000003_gene2996	1.38e-10	61.2	COG1270@1|root,COG1270@2|Bacteria,1MURM@1224|Proteobacteria,2TRZ8@28211|Alphaproteobacteria,4B9KW@82115|Rhizobiaceae	28211|Alphaproteobacteria	H	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group	cobD	-	6.3.1.10	ko:K02227	ko00860,ko01100,map00860,map01100	M00122	R06529,R07302	RC00090,RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	CobD_Cbib
k59_910539_2	1429916.X566_17000	1.6e-67	217.0	COG0614@1|root,COG0614@2|Bacteria,1RAUP@1224|Proteobacteria,2TUB0@28211|Alphaproteobacteria,3JT3Q@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	PFAM periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
k59_1354387_1	935840.JAEQ01000004_gene642	1.38e-55	191.0	COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,2TVYU@28211|Alphaproteobacteria,43I9H@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	EQ	N-methylhydantoinase B acetone carboxylase alpha subunit	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
k59_298029_1	1379698.RBG1_1C00001G0856	4.26e-43	147.0	COG0437@1|root,COG0437@2|Bacteria,2NNV6@2323|unclassified Bacteria	2|Bacteria	C	4Fe-4S dicluster domain	-	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_7
k59_298029_2	1048983.EL17_16325	6.05e-05	47.8	COG0243@1|root,COG1251@1|root,COG0243@2|Bacteria,COG1251@2|Bacteria,4NG4N@976|Bacteroidetes,47JUR@768503|Cytophagia	976|Bacteroidetes	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.7.7.2	ko:K00367	ko00910,ko01120,map00910,map01120	M00531	R00791	RC02812	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_BFD,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,Pyr_redox_2
k59_1244755_1	1173264.KI913949_gene3901	2.83e-20	90.9	COG0647@1|root,COG0647@2|Bacteria,1GET2@1117|Cyanobacteria	1117|Cyanobacteria	G	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_6,Hydrolase_like
k59_1187454_1	258533.BN977_05457	1.53e-07	51.2	COG1522@1|root,COG1522@2|Bacteria,2IQ4Z@201174|Actinobacteria,23AU2@1762|Mycobacteriaceae	201174|Actinobacteria	K	AsnC family	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
k59_1076209_1	1179778.PMM47T1_17990	6.82e-26	112.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,1RNES@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	ABC-Type Dipeptide Transport System Periplasmic Component	dppA	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006457,GO:0006810,GO:0006857,GO:0008150,GO:0009987,GO:0015833,GO:0020037,GO:0030288,GO:0030313,GO:0031975,GO:0033218,GO:0042277,GO:0042597,GO:0042886,GO:0042938,GO:0044464,GO:0046906,GO:0048037,GO:0051179,GO:0051234,GO:0061077,GO:0071702,GO:0071705,GO:0097159,GO:1901363	-	ko:K02035,ko:K12368	ko02010,ko02024,ko02030,map02010,map02024,map02030	M00239,M00324	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	iSSON_1240.SSON_3846	SBP_bac_5
k59_75467_1	926569.ANT_04140	9e-112	344.0	COG0542@1|root,COG0542@2|Bacteria,2G62D@200795|Chloroflexi	200795|Chloroflexi	O	ATPase associated with various cellular activities, AAA_5	-	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_1021400_1	1282362.AEAC466_09845	1.27e-66	218.0	COG3103@1|root,COG4991@2|Bacteria,1QXX4@1224|Proteobacteria,2U4W4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	sh3 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	SH3_3
k59_1743138_1	1459636.NTE_00656	9.78e-72	227.0	COG0104@1|root,arCOG04387@2157|Archaea,41SCA@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
k59_130598_1	926569.ANT_10620	5.79e-62	213.0	COG0517@1|root,COG0617@1|root,COG0618@1|root,COG0517@2|Bacteria,COG0617@2|Bacteria,COG0618@2|Bacteria,2G8YQ@200795|Chloroflexi	200795|Chloroflexi	H	Polynucleotide adenylyltransferase region	-	-	2.7.7.72	ko:K00974	ko03013,map03013	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	CBS,DHH,DHHA1,PolyA_pol,PolyA_pol_RNAbd
k59_743016_1	1095769.CAHF01000010_gene1251	2.17e-106	315.0	COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,2VI71@28216|Betaproteobacteria,472DU@75682|Oxalobacteraceae	28216|Betaproteobacteria	P	Phosphate transporter family	pit	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
k59_1465648_1	1267535.KB906767_gene39	9.4e-31	127.0	COG0577@1|root,COG0577@2|Bacteria,3Y47F@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_1076225_1	1380394.JADL01000002_gene1280	2.79e-55	181.0	COG1385@1|root,COG1385@2|Bacteria,1MXCU@1224|Proteobacteria,2TS0N@28211|Alphaproteobacteria,2JRPI@204441|Rhodospirillales	204441|Rhodospirillales	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	rsmE	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
k59_1076225_2	402881.Plav_0653	1.13e-41	147.0	COG0382@1|root,COG0382@2|Bacteria,1MV4Q@1224|Proteobacteria,2TT3I@28211|Alphaproteobacteria,1JNAB@119043|Rhodobiaceae	28211|Alphaproteobacteria	H	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate	ubiA	-	2.5.1.39	ko:K03179,ko:K06125	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117,M00128	R05000,R05615,R05616,R07273	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
k59_687825_2	742818.HMPREF9451_01444	1.32e-43	155.0	COG0746@1|root,COG1763@1|root,COG0746@2|Bacteria,COG1763@2|Bacteria,2I6HK@201174|Actinobacteria,4CUA7@84998|Coriobacteriia	84998|Coriobacteriia	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	-	-	-	-	-	-	-	-	-	-	MobB,NTP_transf_3
k59_242419_1	391165.GbCGDNIH1_1799	2.55e-07	52.4	COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,2JV4G@204441|Rhodospirillales	204441|Rhodospirillales	L	HTH-like domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve_3
k59_242419_2	1116369.KB890024_gene1817	1.35e-15	72.8	COG4633@1|root,COG4633@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1,DsbD_2,HMA
k59_853014_1	1569209.BBPH01000075_gene777	2.27e-37	140.0	COG3181@1|root,COG3181@2|Bacteria,1MWVK@1224|Proteobacteria,2TXW7@28211|Alphaproteobacteria,2PXZ7@265|Paracoccus	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_22668_1	338963.Pcar_1969	3.22e-60	204.0	COG0480@1|root,COG0480@2|Bacteria,1R0V4@1224|Proteobacteria,42M1F@68525|delta/epsilon subdivisions,2WIYM@28221|Deltaproteobacteria,43RZG@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	elongation factor Tu domain 2 protein	fusA-1	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_1745436_1	443143.GM18_2302	3.44e-23	102.0	COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,42N50@68525|delta/epsilon subdivisions,2WJ23@28221|Deltaproteobacteria,43TM9@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SMC_N
k59_468071_2	861299.J421_2499	1.56e-22	98.2	COG2204@1|root,COG2204@2|Bacteria,1ZSZ6@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_633100_1	296591.Bpro_2557	2.41e-22	94.7	COG2064@1|root,COG2064@2|Bacteria,1MWAZ@1224|Proteobacteria,2VIA4@28216|Betaproteobacteria,4ADRI@80864|Comamonadaceae	28216|Betaproteobacteria	NU	type II secretion system protein	tadC	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
k59_633100_2	324602.Caur_0509	1.15e-24	97.4	COG1430@1|root,COG1430@2|Bacteria,2GAEN@200795|Chloroflexi,375TZ@32061|Chloroflexia	32061|Chloroflexia	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
k59_1023904_2	395493.BegalDRAFT_2790	8.71e-38	140.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RQ9M@1236|Gammaproteobacteria,4620M@72273|Thiotrichales	72273|Thiotrichales	C	Cysteine-rich domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG
k59_855331_1	671143.DAMO_2020	3.61e-45	147.0	COG2963@1|root,COG2963@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	ko:K07483,ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_855331_2	1089552.KI911559_gene2018	2.24e-25	103.0	COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,2JV4G@204441|Rhodospirillales	204441|Rhodospirillales	L	HTH-like domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve_3
k59_1579120_1	1396141.BATP01000007_gene5697	4.22e-25	107.0	COG2960@1|root,COG2960@2|Bacteria,46ZKH@74201|Verrucomicrobia,2IVHR@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Protein of unknown function (DUF1552)	-	-	-	-	-	-	-	-	-	-	-	-	HXXSHH
k59_1134991_1	1306174.JODP01000002_gene5576	2.13e-07	52.4	COG0176@1|root,COG0176@2|Bacteria,2GMF9@201174|Actinobacteria	201174|Actinobacteria	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
k59_1134991_2	1121101.HMPREF1532_03208	1.77e-05	49.7	COG0210@1|root,COG0210@2|Bacteria,4NDWN@976|Bacteroidetes,2FNIM@200643|Bacteroidia,4AMAP@815|Bacteroidaceae	976|Bacteroidetes	L	DNA helicase	pcrA	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_77910_1	1509405.GV67_12655	9.47e-08	53.9	COG0715@1|root,COG0715@2|Bacteria,1PKQN@1224|Proteobacteria,2TSRB@28211|Alphaproteobacteria,4BCDD@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	4,5-dihydroxyphthalate decarboxylase	-	-	4.1.1.55	ko:K04102	ko00624,ko01100,ko01120,map00624,map01100,map01120	M00623	R01635,R05375	RC00390	ko00000,ko00001,ko00002,ko01000	-	-	-	NMT1,Phosphonate-bd
k59_1468212_1	671143.DAMO_1073	1.25e-112	347.0	COG0542@1|root,COG0542@2|Bacteria,2NNNE@2323|unclassified Bacteria	2|Bacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K03694,ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_1690407_1	742733.HMPREF9469_01639	2.4e-11	70.5	COG0043@1|root,COG0043@2|Bacteria,1TQ6V@1239|Firmicutes,248WY@186801|Clostridia,220UU@1506553|Lachnoclostridium	186801|Clostridia	H	3-octaprenyl-4-hydroxybenzoate carboxy-lyase	-	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
k59_1468223_1	997346.HMPREF9374_3293	4.2e-39	139.0	COG1024@1|root,COG1024@2|Bacteria,1TQ2V@1239|Firmicutes,4HBT0@91061|Bacilli,27B90@186824|Thermoactinomycetaceae	91061|Bacilli	I	Enoyl-CoA hydratase/isomerase	-	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
k59_1412466_2	42256.RradSPS_2094	1.26e-12	67.8	COG0584@1|root,COG0584@2|Bacteria,2GJ5W@201174|Actinobacteria,4CQHH@84995|Rubrobacteria	84995|Rubrobacteria	C	glycerophosphoryl diester phosphodiesterase	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
k59_967896_1	985762.SAGN_07778	2.87e-106	321.0	COG0719@1|root,COG0719@2|Bacteria,1TQ21@1239|Firmicutes,4HA1Z@91061|Bacilli,4GWYM@90964|Staphylococcaceae	91061|Bacilli	O	assembly protein SufB	sufB	-	-	ko:K07033,ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
k59_913140_1	1173028.ANKO01000174_gene2700	6.94e-57	197.0	COG4325@1|root,COG4325@2|Bacteria,1G2Y0@1117|Cyanobacteria,1H8XM@1150|Oscillatoriales	1117|Cyanobacteria	S	membrane protein (DUF2254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2254
k59_411753_2	653045.Strvi_3921	6.56e-09	62.4	COG0604@1|root,COG3321@1|root,COG0604@2|Bacteria,COG3321@2|Bacteria	2|Bacteria	Q	synthase	-	-	-	ko:K12431,ko:K12433,ko:K12436,ko:K12442	-	-	-	-	ko00000,ko01004	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2,Acyl_transf_1,Docking,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
k59_468150_1	926569.ANT_01680	1.44e-111	337.0	COG3854@1|root,COG3854@2|Bacteria,2G5P5@200795|Chloroflexi	200795|Chloroflexi	S	PFAM single-stranded nucleic acid binding R3H domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_30,R3H
k59_1135055_1	95619.PM1_0227235	3.4e-93	286.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	belongs to the aldehyde dehydrogenase family	gabD	GO:0000166,GO:0001505,GO:0003674,GO:0003824,GO:0004777,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006105,GO:0006520,GO:0006536,GO:0006538,GO:0006540,GO:0006807,GO:0008150,GO:0008152,GO:0009013,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009448,GO:0009450,GO:0009987,GO:0016054,GO:0016491,GO:0016620,GO:0016903,GO:0017144,GO:0019752,GO:0032787,GO:0036094,GO:0042133,GO:0042135,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046395,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	iECIAI39_1322.ECIAI39_2847,iYL1228.KPN_00256	Aldedh
k59_633184_1	2002.JOEQ01000028_gene8161	5.79e-43	158.0	COG3464@1|root,COG3464@2|Bacteria,2HU54@201174|Actinobacteria,4EIZ7@85012|Streptosporangiales	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3
k59_1468288_1	1238182.C882_2071	2.53e-29	117.0	COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria,2TST5@28211|Alphaproteobacteria,2JPBX@204441|Rhodospirillales	204441|Rhodospirillales	P	COG0530 Ca2 Na antiporter	-	-	-	-	-	-	-	-	-	-	-	-	Na_Ca_ex
k59_913202_2	1123269.NX02_02175	9.86e-67	213.0	28JPA@1|root,2Z9FC@2|Bacteria,1PN1F@1224|Proteobacteria,2TSKX@28211|Alphaproteobacteria,2KC8M@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1357117_1	867845.KI911784_gene2680	6.5e-89	291.0	COG1197@1|root,COG1197@2|Bacteria,2G5UW@200795|Chloroflexi,375DR@32061|Chloroflexia	32061|Chloroflexia	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_1412521_1	1379270.AUXF01000006_gene26	1.22e-16	82.8	COG0457@1|root,COG0457@2|Bacteria,1ZU0J@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_8
k59_189073_1	339670.Bamb_4989	9.21e-14	77.8	COG0515@1|root,COG3903@1|root,COG0515@2|Bacteria,COG3903@2|Bacteria,1QTXV@1224|Proteobacteria,2WGH7@28216|Betaproteobacteria,1KG47@119060|Burkholderiaceae	28216|Betaproteobacteria	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Pkinase
k59_690280_1	1041522.MCOL_V215874	1.17e-47	160.0	COG0479@1|root,COG0479@2|Bacteria,2GP9C@201174|Actinobacteria,234MV@1762|Mycobacteriaceae	201174|Actinobacteria	C	succinate dehydrogenase	sdhB	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_10,Fer4_8
k59_690280_2	403833.Pmob_0487	7.86e-52	169.0	COG3153@1|root,COG3153@2|Bacteria,2GDAJ@200918|Thermotogae	200918|Thermotogae	S	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_1690507_1	926564.KI911656_gene1629	2.22e-18	90.1	COG5297@1|root,COG5297@2|Bacteria,2I2T2@201174|Actinobacteria	201174|Actinobacteria	G	PFAM glycoside hydrolase, family 48	-	-	-	-	-	-	-	-	-	-	-	-	CBM_2,Glyco_hydro_48,fn3
k59_133273_1	405948.SACE_0538	5.41e-20	90.5	COG1319@1|root,COG1319@2|Bacteria,2GT14@201174|Actinobacteria,4DXHU@85010|Pseudonocardiales	201174|Actinobacteria	C	carbon monoxide dehydrogenase	cutM	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
k59_133273_2	1173021.ALWA01000025_gene2530	9.44e-05	43.9	COG1063@1|root,COG1063@2|Bacteria,1FZZE@1117|Cyanobacteria	1117|Cyanobacteria	E	PFAM Alcohol dehydrogenase	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N,Shikimate_DH
k59_1745528_1	1132441.KI519454_gene1831	9.92e-42	142.0	COG3832@1|root,COG3832@2|Bacteria,2ISVS@201174|Actinobacteria	201174|Actinobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
k59_1135083_1	926569.ANT_15860	2.96e-48	176.0	COG1807@1|root,COG5427@1|root,COG1807@2|Bacteria,COG5427@2|Bacteria,2G5UJ@200795|Chloroflexi	200795|Chloroflexi	M	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2298,PMT_2,TPR_16,TPR_19,TPR_8
k59_913239_1	1157634.KB912952_gene6060	1.47e-14	78.2	COG3206@1|root,COG3206@2|Bacteria,2GPMH@201174|Actinobacteria	201174|Actinobacteria	M	Domain of unknown function (DUF4349)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4349
k59_578045_2	1121124.JNIX01000008_gene2389	6.37e-35	131.0	COG0520@1|root,COG0520@2|Bacteria,1PSIC@1224|Proteobacteria,2V4PE@28211|Alphaproteobacteria,2KG8R@204458|Caulobacterales	204458|Caulobacterales	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
k59_1357150_1	509191.AEDB02000035_gene2192	1.35e-85	282.0	COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,1TQ0B@1239|Firmicutes,248IB@186801|Clostridia,3WHE2@541000|Ruminococcaceae	186801|Clostridia	E	glutamate synthase	gltB	-	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_855469_1	1122603.ATVI01000006_gene775	2.76e-34	134.0	COG4783@1|root,COG4783@2|Bacteria,1QV70@1224|Proteobacteria,1RQJV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
k59_1633861_1	1205680.CAKO01000004_gene3632	1.02e-41	153.0	COG1014@1|root,COG1014@2|Bacteria,1MV7Q@1224|Proteobacteria,2TTHE@28211|Alphaproteobacteria,2JQ2E@204441|Rhodospirillales	204441|Rhodospirillales	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	POR
k59_1414294_1	1221522.B723_30585	1.19e-40	145.0	COG1840@1|root,COG1840@2|Bacteria,1MUEG@1224|Proteobacteria,1RQ6Z@1236|Gammaproteobacteria,1YPVI@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	P	Iron ABC transporter	fbpA	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
k59_1026302_1	760568.Desku_2853	8.13e-106	328.0	COG1449@1|root,COG1449@2|Bacteria,1UVAN@1239|Firmicutes,24B0Y@186801|Clostridia,260ZW@186807|Peptococcaceae	186801|Clostridia	G	Belongs to the glycosyl hydrolase 57 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF3536,Glyco_hydro_57
k59_470408_1	644968.DFW101_3102	5.56e-27	117.0	COG0477@1|root,COG0477@2|Bacteria,1RGPN@1224|Proteobacteria,43BMI@68525|delta/epsilon subdivisions,2X6ZQ@28221|Deltaproteobacteria,2MH9D@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	drug resistance transporter, EmrB QacA subfamily	-	-	-	ko:K03446	-	M00701	-	-	ko00000,ko00002,ko02000	2.A.1.3	-	-	MFS_1
k59_524899_1	1187851.A33M_0656	1.32e-34	126.0	COG3382@1|root,COG3382@2|Bacteria,1N6A7@1224|Proteobacteria,2UJ4A@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	B3/4 domain	-	-	-	-	-	-	-	-	-	-	-	-	B3_4
k59_524899_2	1380394.JADL01000001_gene2539	1.37e-33	129.0	COG0607@1|root,COG2897@1|root,COG0607@2|Bacteria,COG2897@2|Bacteria,1MU3V@1224|Proteobacteria,2TSGP@28211|Alphaproteobacteria,2JR05@204441|Rhodospirillales	204441|Rhodospirillales	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_1581217_1	1322246.BN4_10369	5.71e-34	123.0	COG0440@1|root,COG0440@2|Bacteria,1RAGN@1224|Proteobacteria,42RRU@68525|delta/epsilon subdivisions,2WNBY@28221|Deltaproteobacteria,2MB39@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	TIGRFAM Acetolactate synthase, small subunit	ilvN	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C
k59_1581217_2	1410616.JHXE01000006_gene2099	1.75e-23	97.1	COG0059@1|root,COG0059@2|Bacteria,1TPI7@1239|Firmicutes,247RH@186801|Clostridia,3NH6I@46205|Pseudobutyrivibrio	186801|Clostridia	EH	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
k59_1692891_1	401526.TcarDRAFT_2223	2.61e-74	236.0	COG3547@1|root,COG3547@2|Bacteria,1TQP6@1239|Firmicutes,4H519@909932|Negativicutes	909932|Negativicutes	L	transposase IS116 IS110 IS902 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_579749_1	1410668.JNKC01000007_gene800	1.47e-12	72.8	COG0628@1|root,COG0628@2|Bacteria,1TQ84@1239|Firmicutes,248FS@186801|Clostridia,36EAC@31979|Clostridiaceae	186801|Clostridia	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
k59_747368_1	1380390.JIAT01000009_gene1279	4.69e-104	339.0	COG0508@1|root,COG0567@1|root,COG0508@2|Bacteria,COG0567@2|Bacteria,2GIU6@201174|Actinobacteria,4CPG1@84995|Rubrobacteria	84995|Rubrobacteria	C	2-oxoglutarate dehydrogenase C-terminal	-	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,2-oxogl_dehyd_N,Biotin_lipoyl,E1_dh,E3_binding,OxoGdeHyase_C,Transket_pyr
k59_79923_1	1123256.KB907926_gene999	3.57e-08	57.4	COG0835@1|root,COG0835@2|Bacteria,1NA8G@1224|Proteobacteria,1SCB2@1236|Gammaproteobacteria,1X71Z@135614|Xanthomonadales	135614|Xanthomonadales	NT	Two component signalling adaptor domain	-	-	-	ko:K06598	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
k59_1470346_2	1211115.ALIQ01000156_gene4411	1.93e-09	57.8	COG1595@1|root,COG1595@2|Bacteria,1NRNT@1224|Proteobacteria,2TT5K@28211|Alphaproteobacteria,3NBHR@45404|Beijerinckiaceae	28211|Alphaproteobacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_1303427_1	257310.BB2121	2.02e-79	261.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,2VJG2@28216|Betaproteobacteria,3T5Q0@506|Alcaligenaceae	28216|Betaproteobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	fdhA	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_79942_1	293826.Amet_4097	2.27e-25	100.0	COG1633@1|root,COG1633@2|Bacteria,1VAB8@1239|Firmicutes,24SM6@186801|Clostridia	186801|Clostridia	S	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
k59_1635582_1	1463920.JOGB01000003_gene2641	1.2e-31	121.0	COG1277@1|root,COG1277@2|Bacteria,2GKKP@201174|Actinobacteria	201174|Actinobacteria	S	ABC-type transport system involved in multi-copper enzyme maturation permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
k59_470442_2	1417296.U879_20035	4.6e-32	121.0	COG1177@1|root,COG1177@2|Bacteria,1MUQD@1224|Proteobacteria,2TS3C@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	ABC-type spermidine putrescine transport system, permease component	-	-	-	ko:K02053	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	BPD_transp_1
k59_635059_1	504472.Slin_1560	2.35e-35	135.0	COG0318@1|root,COG0318@2|Bacteria,4PN9Z@976|Bacteroidetes,47M0M@768503|Cytophagia	976|Bacteroidetes	IQ	AMP-binding enzyme	-	-	6.2.1.34	ko:K12508	-	-	-	-	ko00000,ko01000	-	-	-	AMP-binding
k59_1303433_1	138119.DSY1584	1.06e-56	195.0	COG1217@1|root,COG1217@2|Bacteria,1TQ5Y@1239|Firmicutes,248EB@186801|Clostridia,2610Y@186807|Peptococcaceae	186801|Clostridia	T	Elongation factor Tu domain 2	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2
k59_747391_1	44251.PDUR_20595	7.37e-60	191.0	COG0503@1|root,COG0503@2|Bacteria,1V1BV@1239|Firmicutes,4HFUA@91061|Bacilli,26QIK@186822|Paenibacillaceae	91061|Bacilli	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	GO:0003674,GO:0003824,GO:0003999,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006168,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009113,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0034641,GO:0034654,GO:0042440,GO:0043094,GO:0043096,GO:0043101,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046083,GO:0046084,GO:0046112,GO:0046148,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
k59_857235_1	926569.ANT_00510	2.87e-72	226.0	COG0061@1|root,COG0061@2|Bacteria,2G6NK@200795|Chloroflexi	200795|Chloroflexi	F	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
k59_579777_1	1502851.FG93_03283	2.14e-117	349.0	COG5361@1|root,COG5361@2|Bacteria,1NX2A@1224|Proteobacteria,2TTBA@28211|Alphaproteobacteria,3JX1U@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1214)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_1080698_1	279010.BL05087	7.35e-14	72.0	COG0604@1|root,COG0604@2|Bacteria,1TRRF@1239|Firmicutes,4HBSF@91061|Bacilli,1ZC7U@1386|Bacillus	91061|Bacilli	C	COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases	yogA	-	-	ko:K13955	-	-	-	-	ko00000	-	-	-	ADH_N,ADH_zinc_N
k59_1080698_2	401053.AciPR4_0570	6.12e-11	67.0	COG1287@1|root,COG1287@2|Bacteria,3Y653@57723|Acidobacteria,2JM89@204432|Acidobacteriia	204432|Acidobacteriia	S	oligosaccharyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1692948_1	926550.CLDAP_34690	3.09e-23	98.2	COG0075@1|root,COG0075@2|Bacteria,2G5P3@200795|Chloroflexi	200795|Chloroflexi	E	PFAM aminotransferase class V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
k59_579791_1	485913.Krac_9271	1.74e-59	199.0	2DBVK@1|root,2ZBBH@2|Bacteria,2G7SF@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1080704_1	547144.HydHO_0819	2.24e-24	103.0	COG2010@1|root,COG2010@2|Bacteria,2G55S@200783|Aquificae	200783|Aquificae	C	Cytochrome c class I	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
k59_803024_1	671143.DAMO_0747	4.07e-84	257.0	COG0022@1|root,COG0022@2|Bacteria,2NNT2@2323|unclassified Bacteria	2|Bacteria	C	Transketolase, pyrimidine binding domain	bfmBA	-	1.2.4.4	ko:K00167,ko:K11381,ko:K21417	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
k59_747419_1	381666.H16_A1164	7.27e-56	176.0	COG0633@1|root,COG0633@2|Bacteria,1RHDC@1224|Proteobacteria,2VSQE@28216|Betaproteobacteria,1K7RJ@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Ferredoxin, 2Fe-2S type, ISC system	fdx	-	-	ko:K04755	-	-	-	-	ko00000	-	-	-	Fer2
k59_747419_2	1517416.IDAT_05545	1.09e-05	48.1	COG0443@1|root,COG0443@2|Bacteria,1MVQI@1224|Proteobacteria,1RN74@1236|Gammaproteobacteria,2QFJY@267893|Idiomarinaceae	1236|Gammaproteobacteria	O	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB	hscA	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0009266,GO:0009409,GO:0009628,GO:0009987,GO:0010467,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043531,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0050896,GO:0051604,GO:0051716,GO:0070417,GO:0071704,GO:0097159,GO:0097367,GO:0097428,GO:1901265,GO:1901363,GO:1901564,GO:1902494,GO:1990230,GO:1990234	-	ko:K04044	-	-	-	-	ko00000,ko03110	1.A.33	-	-	HSP70
k59_1414363_1	981384.AEYW01000014_gene146	4.14e-87	270.0	COG1234@1|root,COG1234@2|Bacteria,1R64Z@1224|Proteobacteria,2U0BA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III	-	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B,Lactamase_B_2
k59_1055786_1	1357272.AVEO02000033_gene2554	0.000519	48.5	COG0747@1|root,COG0747@2|Bacteria,1P1HT@1224|Proteobacteria,1RQ7Z@1236|Gammaproteobacteria,1Z8WQ@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	nikA	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006935,GO:0008150,GO:0009605,GO:0016151,GO:0020037,GO:0030288,GO:0030313,GO:0031975,GO:0040011,GO:0042221,GO:0042330,GO:0042597,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050896,GO:0050919,GO:0051540,GO:0097159,GO:1901363	-	ko:K02035,ko:K15584	ko02010,ko02024,map02010,map02024	M00239,M00440	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	iSFV_1184.SFV_3479	SBP_bac_5
k59_51819_1	589865.DaAHT2_1284	3.73e-64	209.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,42MUZ@68525|delta/epsilon subdivisions,2WJT6@28221|Deltaproteobacteria,2MHUV@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_773871_1	1244869.H261_14470	1.27e-06	51.6	COG1210@1|root,COG1210@2|Bacteria,1MV5F@1224|Proteobacteria,2TRT6@28211|Alphaproteobacteria,2JPPP@204441|Rhodospirillales	204441|Rhodospirillales	M	UTP--glucose-1-phosphate uridylyltransferase	exoN	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
k59_1219136_1	326297.Sama_2422	5.69e-16	83.2	COG1506@1|root,COG1506@2|Bacteria,1MWFI@1224|Proteobacteria,1RPJD@1236|Gammaproteobacteria,2QASC@267890|Shewanellaceae	1236|Gammaproteobacteria	E	PFAM peptidase S9 prolyl oligopeptidase active site domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DPPIV_N,Peptidase_S9
k59_1389253_1	1430440.MGMSRv2_3072	5.3e-24	95.1	COG3335@1|root,COG3335@2|Bacteria,1P76X@1224|Proteobacteria,2U16U@28211|Alphaproteobacteria,2JSK6@204441|Rhodospirillales	204441|Rhodospirillales	L	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
k59_1389253_2	1185652.USDA257_c02570	3.63e-24	102.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1P76X@1224|Proteobacteria,2U16U@28211|Alphaproteobacteria,4BC2J@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Transposase and inactivated	-	-	-	ko:K07494	-	-	-	-	ko00000	-	-	-	DDE_3
k59_1720695_1	743299.Acife_2622	2.9e-71	236.0	COG1252@1|root,COG2259@1|root,COG1252@2|Bacteria,COG2259@2|Bacteria,1MX96@1224|Proteobacteria,1RM9I@1236|Gammaproteobacteria,2NDMM@225057|Acidithiobacillales	225057|Acidithiobacillales	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.99.3	ko:K03885,ko:K15977	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	DoxX,Pyr_redox_2
k59_442124_1	1380346.JNIH01000025_gene4627	1.48e-07	57.0	COG0500@1|root,COG2226@2|Bacteria,2H38T@201174|Actinobacteria	201174|Actinobacteria	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_442124_2	1047013.AQSP01000033_gene1389	2.08e-12	67.4	COG0639@1|root,COG0639@2|Bacteria,2NPHT@2323|unclassified Bacteria	2|Bacteria	T	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
k59_1110011_1	926566.Terro_4185	4.4e-11	68.2	COG0667@1|root,COG0667@2|Bacteria,3Y2KB@57723|Acidobacteria,2JJ0N@204432|Acidobacteriia	204432|Acidobacteriia	C	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_1776049_1	697281.Mahau_2583	1.41e-57	189.0	COG1210@1|root,COG1210@2|Bacteria,1TQ24@1239|Firmicutes,25E5A@186801|Clostridia,42EY9@68295|Thermoanaerobacterales	186801|Clostridia	M	TIGRFAM UTP--glucose-1-phosphate uridylyltransferase	galU	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
k59_1219159_1	1255043.TVNIR_2678	8.27e-110	326.0	COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,1RM7Q@1236|Gammaproteobacteria,1WXFU@135613|Chromatiales	135613|Chromatiales	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
k59_386616_1	1111479.AXAR01000010_gene2629	3.08e-35	131.0	COG3638@1|root,COG3638@2|Bacteria,1TQG6@1239|Firmicutes,4HC3N@91061|Bacilli,2789Q@186823|Alicyclobacillaceae	91061|Bacilli	P	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system	phnC	GO:0006810,GO:0008150,GO:0015716,GO:0051179,GO:0051234,GO:0071702	3.6.3.28	ko:K02041	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.9	-	-	ABC_tran
k59_1219166_1	649747.HMPREF0083_06040	2.88e-30	114.0	COG1544@1|root,COG1544@2|Bacteria,1V1D5@1239|Firmicutes,4HFX9@91061|Bacilli,26R9J@186822|Paenibacillaceae	91061|Bacilli	J	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase	hpf	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0017148,GO:0019222,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:1990904,GO:2000112,GO:2000113	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosom_S30AE_C,Ribosomal_S30AE
k59_1219166_2	536232.CLM_3839	6.02e-21	90.1	COG1660@1|root,COG1660@2|Bacteria,1TPS4@1239|Firmicutes,248KQ@186801|Clostridia,36DI8@31979|Clostridiaceae	186801|Clostridia	S	Displays ATPase and GTPase activities	yvcJ	-	-	ko:K06958	-	-	-	-	ko00000,ko03019	-	-	-	ATP_bind_2
k59_1776089_1	1133850.SHJG_1549	3.25e-68	219.0	COG3328@1|root,COG3328@2|Bacteria,2GM8F@201174|Actinobacteria	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_1167469_1	67267.JNXT01000040_gene4651	4.75e-67	212.0	COG2197@1|root,COG2197@2|Bacteria,2IIDD@201174|Actinobacteria	201174|Actinobacteria	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_1609804_1	909663.KI867150_gene1309	1.55e-25	107.0	COG2801@1|root,COG2801@2|Bacteria,1R6TH@1224|Proteobacteria,42VCD@68525|delta/epsilon subdivisions,2WRUC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,Mu-transpos_C,rve
k59_164006_1	290318.Cvib_1462	8.09e-15	80.1	COG1196@1|root,COG1196@2|Bacteria,1FDPC@1090|Chlorobi	1090|Chlorobi	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
k59_1055918_1	1235794.C811_00790	1.37e-61	214.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2GK73@201174|Actinobacteria,4CUB1@84998|Coriobacteriia	84998|Coriobacteriia	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_1442986_2	468556.AQYG01000034_gene3378	4.78e-19	86.3	COG0626@1|root,COG0626@2|Bacteria,2GJ5S@201174|Actinobacteria,4GATP@85026|Gordoniaceae	201174|Actinobacteria	E	Cys/Met metabolism PLP-dependent enzyme	metB	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006534,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009086,GO:0009092,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0017144,GO:0019279,GO:0019343,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071265,GO:0071266,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.48	ko:K01739	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00420,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1079	Cys_Met_Meta_PP
k59_51932_1	69279.BG36_21400	2.61e-71	224.0	COG0566@1|root,COG0566@2|Bacteria,1MWBE@1224|Proteobacteria,2TT4Y@28211|Alphaproteobacteria,43HZX@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	spoU	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase,SpoU_sub_bind
k59_662021_1	1120792.JAFV01000001_gene2941	9.19e-33	121.0	COG0325@1|root,COG0325@2|Bacteria,1MWN7@1224|Proteobacteria,2TR5Z@28211|Alphaproteobacteria,36XZF@31993|Methylocystaceae	28211|Alphaproteobacteria	S	Alanine racemase, N-terminal domain	MA20_24865	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
k59_1219230_1	351746.Pput_3472	1.96e-114	336.0	COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,1RNSW@1236|Gammaproteobacteria,1YX1S@136845|Pseudomonas putida group	1236|Gammaproteobacteria	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	GO:0003674,GO:0003824,GO:0004477,GO:0004486,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0019752,GO:0034641,GO:0042558,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0055114,GO:0071704,GO:1901360,GO:1901564	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	iSDY_1059.SDY_0281	THF_DHG_CYH,THF_DHG_CYH_C
k59_1443008_1	504474.cu0884	1.41e-16	80.9	COG1974@1|root,COG1974@2|Bacteria,2GMBN@201174|Actinobacteria,22KVU@1653|Corynebacteriaceae	201174|Actinobacteria	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006974,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032991,GO:0032993,GO:0033554,GO:0042221,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045934,GO:0046677,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
k59_606531_1	338963.Pcar_2400	5.9e-53	176.0	COG1691@1|root,COG1691@2|Bacteria,1REQ7@1224|Proteobacteria,42MJG@68525|delta/epsilon subdivisions,2WN0G@28221|Deltaproteobacteria,43S7Z@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	AIR carboxylase	-	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
k59_998289_1	1211114.ALIP01000037_gene112	6.58e-65	218.0	COG3661@1|root,COG3661@2|Bacteria,1MXKA@1224|Proteobacteria,1RP0V@1236|Gammaproteobacteria,1X5RV@135614|Xanthomonadales	135614|Xanthomonadales	G	Belongs to the glycosyl hydrolase 67 family	aguA	-	3.2.1.139	ko:K01235	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_hydro_67C,Glyco_hydro_67M,Glyco_hydro_67N
k59_662050_1	366394.Smed_6107	1.38e-20	95.1	COG3482@1|root,COG3482@2|Bacteria,1N2YR@1224|Proteobacteria,2TVTG@28211|Alphaproteobacteria,4BCTF@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	TfuA-like protein	-	-	-	-	-	-	-	-	-	-	-	-	TfuA
k59_1110144_2	1121861.KB899945_gene3956	4.92e-22	97.1	COG0154@1|root,COG0154@2|Bacteria,1MWRI@1224|Proteobacteria,2TTJU@28211|Alphaproteobacteria,2JQU6@204441|Rhodospirillales	204441|Rhodospirillales	J	COG0154 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit and related amidases	-	-	-	-	-	-	-	-	-	-	-	-	Amidase
k59_1056042_1	1229780.BN381_130031	3.15e-34	127.0	COG1214@1|root,COG1214@2|Bacteria,2GMTM@201174|Actinobacteria,3UWTU@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	O	Glycoprotease family	yeaZ	GO:0002949,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030312,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0071944,GO:0090304,GO:1901360	-	ko:K14742	-	-	-	-	ko00000,ko03016	-	-	-	Peptidase_M22
k59_220837_1	118168.MC7420_1326	1.68e-75	243.0	COG1506@1|root,COG1506@2|Bacteria,1G200@1117|Cyanobacteria,1H8T3@1150|Oscillatoriales	1117|Cyanobacteria	E	PFAM Prolyl oligopeptidase family	dap2	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
k59_611412_1	485913.Krac_5027	3.3e-05	51.2	COG2909@1|root,COG3903@1|root,COG2909@2|Bacteria,COG3903@2|Bacteria,2G7SC@200795|Chloroflexi	200795|Chloroflexi	K	intracellular signal transduction	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,TPR_12
k59_611506_1	479434.Sthe_0985	2.12e-94	293.0	COG0277@1|root,COG0277@2|Bacteria,2G5TM@200795|Chloroflexi,27XF8@189775|Thermomicrobia	189775|Thermomicrobia	C	FAD linked oxidases, C-terminal domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_277591_1	1207063.P24_10685	8.36e-48	173.0	COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,2TS4D@28211|Alphaproteobacteria,2JPKU@204441|Rhodospirillales	204441|Rhodospirillales	S	Penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
k59_220992_1	396588.Tgr7_2033	1.27e-77	253.0	COG4664@1|root,COG4665@1|root,COG4664@2|Bacteria,COG4665@2|Bacteria,1R4MZ@1224|Proteobacteria,1RMR6@1236|Gammaproteobacteria,1WWHM@135613|Chromatiales	135613|Chromatiales	Q	TRAP C4-dicarboxylate transport system permease DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM,DctQ
k59_277673_1	740709.A10D4_02865	3.22e-101	312.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MWGR@1224|Proteobacteria,1RR88@1236|Gammaproteobacteria,2QF7B@267893|Idiomarinaceae	1236|Gammaproteobacteria	EU	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	DPPIV_N,PD40,Peptidase_S9
k59_277854_1	114615.BRADO5530	5.63e-170	486.0	COG2801@1|root,COG3415@1|root,COG2801@2|Bacteria,COG3415@2|Bacteria,1N207@1224|Proteobacteria,2UEQQ@28211|Alphaproteobacteria,3JWDD@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_28,HTH_32,LZ_Tnp_IS481,rve,rve_3
k59_221214_1	1386089.N865_04190	2.78e-05	51.6	COG2114@1|root,COG3437@1|root,COG2114@2|Bacteria,COG3437@2|Bacteria,2GNPX@201174|Actinobacteria,4FFVN@85021|Intrasporangiaceae	201174|Actinobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	osaB	-	-	-	-	-	-	-	-	-	-	-	Response_reg
k59_277877_1	384765.SIAM614_13933	6.82e-27	113.0	COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,2USBQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	COG2274 ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain	-	-	-	ko:K06147,ko:K06148,ko:K12541	ko02010,map02010	M00330	-	-	ko00000,ko00001,ko00002,ko02000,ko02044	3.A.1,3.A.1.106,3.A.1.109,3.A.1.109.3,3.A.1.109.4,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_277887_1	1519464.HY22_09120	1.59e-15	82.0	COG1538@1|root,COG1538@2|Bacteria,1FE66@1090|Chlorobi	1090|Chlorobi	MU	PFAM outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_221265_1	697282.Mettu_4406	4.82e-64	209.0	COG2801@1|root,COG2801@2|Bacteria,1MWVQ@1224|Proteobacteria,1RN12@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_28,HTH_32,rve
k59_277947_1	926569.ANT_16290	2.07e-106	325.0	COG2759@1|root,COG2759@2|Bacteria,2G5QS@200795|Chloroflexi	200795|Chloroflexi	F	Belongs to the formate--tetrahydrofolate ligase family	fhs	GO:0003674,GO:0003824,GO:0004329,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006144,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009112,GO:0009113,GO:0009256,GO:0009257,GO:0009396,GO:0009987,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0016874,GO:0016879,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042440,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.5.1.5,3.5.4.9,6.3.4.3	ko:K00288,ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00141,M00377	R00943,R01220,R01655	RC00026,RC00111,RC00202,RC00578	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	FTHFS
k59_222036_2	861299.J421_2566	6.88e-75	234.0	COG0223@1|root,COG0223@2|Bacteria,1ZTE5@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
k59_222084_1	338966.Ppro_0762	8.6e-30	119.0	COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,42N97@68525|delta/epsilon subdivisions,2WKVE@28221|Deltaproteobacteria,43S28@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	CBS domain containing protein	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
k59_222333_1	1340493.JNIF01000003_gene3594	1.91e-16	79.7	COG1171@1|root,COG1171@2|Bacteria,3Y2UN@57723|Acidobacteria	57723|Acidobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_222333_2	1280380.KR100_07885	1.23e-44	159.0	COG0277@1|root,COG0277@2|Bacteria,1GEPG@1117|Cyanobacteria,1H2IC@1129|Synechococcus	1117|Cyanobacteria	C	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_4
k59_222377_1	1122915.AUGY01000022_gene6730	1.12e-05	53.5	COG4585@1|root,COG4585@2|Bacteria,1TQI3@1239|Firmicutes,4HAUU@91061|Bacilli,26T94@186822|Paenibacillaceae	91061|Bacilli	T	Member of the two-component regulatory system DegS DegU, which plays an important role in the transition growth phase	degS	-	2.7.13.3	ko:K07777	ko02020,map02020	M00478	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DegS,HATPase_c,HisKA_3
k59_1391012_1	264198.Reut_C6311	9.68e-65	208.0	COG0715@1|root,COG0715@2|Bacteria,1NS24@1224|Proteobacteria	1224|Proteobacteria	P	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components	-	-	-	-	-	-	-	-	-	-	-	-	NMT1_2
k59_1113107_1	1117318.PRUB_10457	7.5e-51	183.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,2Q0VD@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	I	Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate	fadB	GO:0003674,GO:0003824,GO:0003857,GO:0004165,GO:0004300,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0008692,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0016856,GO:0016860,GO:0016863,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575	1.1.1.35,4.2.1.17,5.1.2.3,5.3.3.8	ko:K01782,ko:K01825	ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R04756,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01078,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	iLF82_1304.LF82_0614,iNRG857_1313.NRG857_19200	3HCDH,3HCDH_N,ECH_1
k59_1557780_1	883078.HMPREF9695_03585	7.89e-82	256.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TUX3@28211|Alphaproteobacteria,3K392@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Thiolase, C-terminal domain	-	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_1613331_1	1443113.LC20_01330	2.67e-32	122.0	COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,1RN41@1236|Gammaproteobacteria,41D5P@629|Yersinia	1236|Gammaproteobacteria	K	phosphate regulon transcriptional regulatory protein PhoB	phoB	GO:0001098,GO:0001108,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0042802,GO:0043254,GO:0044087,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2000142,GO:2001141	-	ko:K07657	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_334658_1	1238182.C882_1362	1.4e-109	335.0	COG0189@1|root,COG0454@1|root,COG0189@2|Bacteria,COG0456@2|Bacteria,1MVN2@1224|Proteobacteria,2TUT9@28211|Alphaproteobacteria,2JQH6@204441|Rhodospirillales	204441|Rhodospirillales	HJK	RimK-like ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,RimK
k59_112322_1	338963.Pcar_2776	1.31e-38	147.0	COG0204@1|root,COG0318@1|root,COG0477@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,COG2814@2|Bacteria,1MWDY@1224|Proteobacteria,43BJD@68525|delta/epsilon subdivisions,2WKPU@28221|Deltaproteobacteria,43UEA@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	Phosphate acyltransferases	-	-	2.3.1.40,6.2.1.20	ko:K05939	ko00071,ko00564,map00071,map00564	-	R01406,R04864	RC00014,RC00039,RC00041	ko00000,ko00001,ko01000	-	-	-	AMP-binding,Acyltransferase,MFS_1,PP-binding
k59_668296_1	626887.J057_06051	1.15e-74	245.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,464P3@72275|Alteromonadaceae	1236|Gammaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	fadN	-	1.1.1.35	ko:K07516	ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212	M00087	R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
k59_1446677_1	1246448.ANAZ01000011_gene636	2.15e-09	58.9	COG1309@1|root,COG1309@2|Bacteria,2GNR9@201174|Actinobacteria,4EJ48@85012|Streptosporangiales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_1446677_2	649638.Trad_1638	1.21e-20	92.8	COG0441@1|root,COG0441@2|Bacteria,1WI8Y@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
k59_890704_1	688269.Theth_1540	4.14e-09	57.4	COG0165@1|root,COG0165@2|Bacteria,2GDVX@200918|Thermotogae	200918|Thermotogae	E	argininosuccinate lyase	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Lyase_1
k59_890704_2	66373.JOFQ01000002_gene5202	8.51e-14	74.7	COG0548@1|root,COG0548@2|Bacteria,2GX9F@201174|Actinobacteria	201174|Actinobacteria	E	Amino acid kinase family	-	-	-	ko:K05828	ko00220,ko00300,ko01100,ko01110,ko01210,ko01230,map00220,map00300,map01100,map01110,map01210,map01230	M00031,M00763	R09776,R10930	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
k59_1391036_1	1382359.JIAL01000001_gene1318	5.84e-51	172.0	COG1244@1|root,COG1244@2|Bacteria	2|Bacteria	S	Elongator protein 3, MiaB family, Radical SAM	-	-	-	ko:K06936	-	-	-	-	ko00000	-	-	-	-
k59_1224312_1	1144310.PMI07_005299	4.76e-27	112.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TVI3@28211|Alphaproteobacteria,4BCQJ@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	-	-	-	-	-	-	-	-	-	TctA,TctB
k59_167960_1	1043205.AFYF01000083_gene1896	1.55e-08	60.1	COG0584@1|root,COG0584@2|Bacteria,2GIY5@201174|Actinobacteria,4FGUJ@85021|Intrasporangiaceae	201174|Actinobacteria	C	Glycerophosphoryl diester phosphodiesterase family	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
k59_890741_1	471852.Tcur_2549	8.85e-21	96.7	COG0457@1|root,COG1672@1|root,COG0457@2|Bacteria,COG1672@2|Bacteria,2IEQR@201174|Actinobacteria,4EIC4@85012|Streptosporangiales	201174|Actinobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
k59_557095_1	997296.PB1_08262	1.44e-23	97.4	COG1077@1|root,COG1077@2|Bacteria,1TP51@1239|Firmicutes,4HA4S@91061|Bacilli,1ZC87@1386|Bacillus	91061|Bacilli	D	Rod shape-determining protein	mbl	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
k59_557095_2	1440774.Y900_006790	0.000145	45.4	COG0266@1|root,COG0266@2|Bacteria,2GKCW@201174|Actinobacteria,232F6@1762|Mycobacteriaceae	201174|Actinobacteria	L	Belongs to the FPG family	nei	GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363	4.2.99.18	ko:K05522	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
k59_167981_1	1381751.JAJB01000018_gene2391	4.34e-11	60.5	2BXMA@1|root,2ZBQ1@2|Bacteria,2IK3R@201174|Actinobacteria,4FA7J@85019|Brevibacteriaceae	201174|Actinobacteria	S	(twin-arginine translocation) pathway signal	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_167981_2	1286093.C266_15487	3.68e-74	239.0	COG2303@1|root,COG2303@2|Bacteria,1MU3F@1224|Proteobacteria,2VIBA@28216|Betaproteobacteria,1KFJJ@119060|Burkholderiaceae	28216|Betaproteobacteria	E	PFAM glucose-methanol-choline oxidoreductase	-	-	1.1.3.6	ko:K03333	ko00984,ko01120,map00984,map01120	-	R01459	RC00146	ko00000,ko00001,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N,NAD_binding_8
k59_501524_2	1461579.CCNK01000034_gene1304	2.68e-09	58.9	COG0037@1|root,COG0037@2|Bacteria,1MW5Q@1224|Proteobacteria,1RN2H@1236|Gammaproteobacteria,1Y6ZF@135625|Pasteurellales	135625|Pasteurellales	J	Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system	ttcA	-	-	ko:K14058	-	-	-	-	ko00000,ko03016	-	-	-	ATP_bind_3
k59_557103_2	255470.cbdbA1487	1e-119	348.0	COG2801@1|root,COG2801@2|Bacteria,2G8GQ@200795|Chloroflexi,34DDP@301297|Dehalococcoidia	301297|Dehalococcoidia	L	PFAM Integrase catalytic region	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
k59_557103_3	244582.JQAK01000012_gene2377	3.66e-33	117.0	COG2963@1|root,COG2963@2|Bacteria,1RGZ5@1224|Proteobacteria,2UAIS@28211|Alphaproteobacteria,47FV9@766|Rickettsiales	766|Rickettsiales	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
k59_334727_1	402881.Plav_1757	4.08e-77	241.0	COG0183@1|root,COG0183@2|Bacteria,1MUZV@1224|Proteobacteria,2TRHF@28211|Alphaproteobacteria,1JPBG@119043|Rhodobiaceae	28211|Alphaproteobacteria	I	acetyl-coa acetyltransferase	MA20_35590	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	-
k59_334727_2	443598.AUFA01000034_gene7229	5.48e-20	83.2	COG1545@1|root,COG1545@2|Bacteria,1RB09@1224|Proteobacteria,2U5BV@28211|Alphaproteobacteria,3JY0M@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	DUF35 OB-fold domain, acyl-CoA-associated	MA20_35595	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
k59_446017_1	102107.XP_008243633.1	1.01e-15	81.6	COG2124@1|root,KOG0157@2759|Eukaryota,37RT3@33090|Viridiplantae,3GB2G@35493|Streptophyta,4JEZH@91835|fabids	35493|Streptophyta	Q	Belongs to the cytochrome P450 family	-	GO:0001101,GO:0003674,GO:0003824,GO:0004497,GO:0006066,GO:0006082,GO:0006629,GO:0006694,GO:0006714,GO:0006720,GO:0006721,GO:0006950,GO:0007275,GO:0008150,GO:0008152,GO:0008202,GO:0008300,GO:0008610,GO:0009056,GO:0009058,GO:0009314,GO:0009414,GO:0009415,GO:0009416,GO:0009628,GO:0009639,GO:0009687,GO:0009987,GO:0010035,GO:0010268,GO:0010295,GO:0010817,GO:0016042,GO:0016054,GO:0016107,GO:0016115,GO:0016125,GO:0016128,GO:0016129,GO:0016131,GO:0016132,GO:0016491,GO:0016705,GO:0016709,GO:0019752,GO:0032501,GO:0032502,GO:0032787,GO:0042221,GO:0042445,GO:0042446,GO:0042592,GO:0043288,GO:0043290,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046164,GO:0046345,GO:0046395,GO:0048856,GO:0048878,GO:0050896,GO:0055088,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:0072329,GO:1901360,GO:1901362,GO:1901575,GO:1901576,GO:1901615,GO:1901616,GO:1901617,GO:1901700,GO:1902644	-	ko:K07437	ko00830,ko01100,map00830,map01100	-	R08390,R08392	RC00723,RC00724	ko00000,ko00001,ko00199	-	-	-	p450
k59_390407_1	1163617.SCD_n01020	3.96e-21	92.8	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2VHB9@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding	iorB	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,TAT_signal
k59_626232_1	1410616.JHXE01000008_gene1224	3.99e-19	89.4	COG1193@1|root,COG1193@2|Bacteria,1TP5W@1239|Firmicutes,248YK@186801|Clostridia,3NGE0@46205|Pseudobutyrivibrio	186801|Clostridia	L	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_V,Smr
k59_626232_2	671143.DAMO_2756	4.36e-37	139.0	COG0358@1|root,COG0358@2|Bacteria,2NNNJ@2323|unclassified Bacteria	2|Bacteria	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	GO:0003674,GO:0003824,GO:0003896,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006269,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090304,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,DnaG_DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
k59_1182687_2	344747.PM8797T_05105	5.88e-27	109.0	COG0477@1|root,COG2814@2|Bacteria,2J067@203682|Planctomycetes	203682|Planctomycetes	EGP	Major facilitator superfamily	-	-	-	ko:K07552	-	-	-	-	ko00000,ko02000	2.A.1.2	-	-	MFS_1
k59_1127780_1	1266909.AUAG01000009_gene562	5.57e-12	69.3	COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,1RPFM@1236|Gammaproteobacteria,1WXRZ@135613|Chromatiales	135613|Chromatiales	M	PFAM AsmA family protein	-	-	-	ko:K07289	-	-	-	-	ko00000	-	-	-	AsmA
k59_1127781_1	1121396.KB892970_gene1041	5.52e-30	121.0	COG3385@1|root,COG3385@2|Bacteria,1MVRM@1224|Proteobacteria,42U5W@68525|delta/epsilon subdivisions,2WQUQ@28221|Deltaproteobacteria,2MKFC@213118|Desulfobacterales	28221|Deltaproteobacteria	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,Nterm_IS4
k59_960287_1	926569.ANT_04640	7.55e-40	137.0	COG2852@1|root,COG2852@2|Bacteria,2G78G@200795|Chloroflexi	200795|Chloroflexi	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_626253_1	926569.ANT_09360	1.26e-49	169.0	COG1158@1|root,COG1158@2|Bacteria,2G5UQ@200795|Chloroflexi	200795|Chloroflexi	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
k59_1127788_1	35128.Thaps5319	6.78e-106	330.0	COG1506@1|root,KOG2100@2759|Eukaryota	2759|Eukaryota	E	serine-type peptidase activity	-	-	3.4.14.5	ko:K01278,ko:K01282	ko04974,map04974	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	DPPIV_N,Peptidase_S9
k59_348316_1	748247.AZKH_4535	1e-09	55.8	COG1925@1|root,COG1925@2|Bacteria,1N6RM@1224|Proteobacteria,2VU8W@28216|Betaproteobacteria,2KWVF@206389|Rhodocyclales	206389|Rhodocyclales	G	Phosphotransferase System	ptsH	-	-	ko:K11189	-	-	-	-	ko00000,ko02000	4.A.2.1	-	-	PTS-HPr
k59_348316_2	1218074.BAXZ01000015_gene3256	7.39e-14	76.3	COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,2VH9N@28216|Betaproteobacteria,1JZP5@119060|Burkholderiaceae	28216|Betaproteobacteria	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ptsI	-	2.7.3.9	ko:K08483	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
k59_1682952_1	518766.Rmar_1857	5.01e-51	179.0	COG0471@1|root,COG0569@1|root,COG0471@2|Bacteria,COG0569@2|Bacteria,4NF52@976|Bacteroidetes,1FIP9@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	P	Sodium:sulfate symporter transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,TrkA_C
k59_515712_2	1054860.KB913030_gene3436	2.58e-12	67.0	COG0596@1|root,COG0596@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on ester bonds	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
k59_70688_1	1190603.AJYD01000059_gene1636	1.01e-06	57.4	COG0845@1|root,COG0845@2|Bacteria,1MVFN@1224|Proteobacteria,1RNN6@1236|Gammaproteobacteria,1XTRP@135623|Vibrionales	135623|Vibrionales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K18990	-	M00720	-	-	ko00000,ko00002,ko02000	2.A.6.2.30,8.A.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
k59_848558_1	1117315.AHCA01000006_gene2801	6.66e-52	181.0	COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,1RN0W@1236|Gammaproteobacteria,2Q0T7@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	E	COG0006 Xaa-Pro aminopeptidase	pepP	GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0016787,GO:0019538,GO:0030145,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AMP_N,Peptidase_M24
k59_1349371_1	797210.Halxa_4052	1.53e-25	104.0	COG3839@1|root,arCOG00177@2157|Archaea,2XSVD@28890|Euryarchaeota,23SSF@183963|Halobacteria	183963|Halobacteria	E	COG3839 ABC-type sugar transport systems, ATPase components	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE_2
k59_905384_1	6238.CBG12176	1.22e-08	63.9	COG0494@1|root,COG5531@1|root,KOG2570@2759|Eukaryota,KOG3904@2759|Eukaryota,38CY5@33154|Opisthokonta,3B98S@33208|Metazoa,3CU8T@33213|Bilateria,40AP4@6231|Nematoda,1KTQ2@119089|Chromadorea,40T43@6236|Rhabditida	33208|Metazoa	BK	RNA polymerase II transcription factor binding	SMARCD2	GO:0000228,GO:0000785,GO:0000790,GO:0000791,GO:0000793,GO:0001085,GO:0001654,GO:0001672,GO:0002052,GO:0003002,GO:0003007,GO:0003128,GO:0003139,GO:0003205,GO:0003206,GO:0003207,GO:0003208,GO:0003211,GO:0003215,GO:0003219,GO:0003231,GO:0003407,GO:0003674,GO:0003676,GO:0003677,GO:0003682,GO:0003712,GO:0003713,GO:0005102,GO:0005198,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005635,GO:0005654,GO:0005694,GO:0005719,GO:0005737,GO:0006139,GO:0006325,GO:0006333,GO:0006337,GO:0006338,GO:0006351,GO:0006355,GO:0006357,GO:0006725,GO:0006807,GO:0006996,GO:0007275,GO:0007346,GO:0007389,GO:0007399,GO:0007406,GO:0007423,GO:0007507,GO:0008092,GO:0008134,GO:0008150,GO:0008152,GO:0008284,GO:0008285,GO:0009058,GO:0009059,GO:0009653,GO:0009887,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010092,GO:0010389,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010564,GO:0010604,GO:0010628,GO:0010638,GO:0010720,GO:0010721,GO:0010847,GO:0010971,GO:0012505,GO:0016043,GO:0016070,GO:0016514,GO:0016586,GO:0016922,GO:0017022,GO:0018130,GO:0019216,GO:0019219,GO:0019222,GO:0019438,GO:0019904,GO:0022008,GO:0022411,GO:0030154,GO:0030374,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031445,GO:0031453,GO:0031498,GO:0031967,GO:0031974,GO:0031975,GO:0031981,GO:0032501,GO:0032502,GO:0032774,GO:0032947,GO:0032984,GO:0032986,GO:0032991,GO:0033043,GO:0033044,GO:0034641,GO:0034645,GO:0034654,GO:0034728,GO:0035060,GO:0035257,GO:0040029,GO:0042127,GO:0042692,GO:0043010,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043393,GO:0043933,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044454,GO:0044464,GO:0045595,GO:0045596,GO:0045597,GO:0045787,GO:0045799,GO:0045815,GO:0045893,GO:0045931,GO:0045935,GO:0046483,GO:0048096,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048645,GO:0048646,GO:0048699,GO:0048731,GO:0048856,GO:0048869,GO:0050767,GO:0050768,GO:0050769,GO:0050789,GO:0050793,GO:0050794,GO:0051093,GO:0051094,GO:0051098,GO:0051128,GO:0051130,GO:0051147,GO:0051149,GO:0051150,GO:0051152,GO:0051171,GO:0051173,GO:0051239,GO:0051240,GO:0051241,GO:0051252,GO:0051254,GO:0051276,GO:0051427,GO:0051726,GO:0051960,GO:0051961,GO:0051962,GO:0060041,GO:0060255,GO:0060284,GO:0060914,GO:0061061,GO:0065007,GO:0065009,GO:0070013,GO:0070603,GO:0071564,GO:0071565,GO:0071704,GO:0071824,GO:0071840,GO:0072091,GO:0072359,GO:0080090,GO:0090068,GO:0090304,GO:0097159,GO:0097458,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1901987,GO:1901989,GO:1901990,GO:1901992,GO:1902275,GO:1902494,GO:1902680,GO:1902692,GO:1902749,GO:1902751,GO:1903506,GO:1903508,GO:1904949,GO:1905269,GO:2000026,GO:2000112,GO:2000177,GO:2000178,GO:2000179,GO:2000647,GO:2000648,GO:2001141,GO:2001252	-	ko:K11650	ko04714,ko05225,map04714,map05225	-	-	-	ko00000,ko00001,ko03021,ko03036	-	-	-	SWIB
k59_460675_1	291985.CCSI01000001_gene2580	0.000303	48.5	COG1506@1|root,COG1506@2|Bacteria,1P6E1@1224|Proteobacteria,2TRVE@28211|Alphaproteobacteria,2K0U1@204457|Sphingomonadales	204457|Sphingomonadales	E	peptidase S9	-	-	3.4.14.5	ko:K01278	ko04974,map04974	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	DPPIV_N,Peptidase_S9
k59_1626888_1	871963.Desdi_0140	4.16e-09	55.1	COG1006@1|root,COG1006@2|Bacteria,1V7CR@1239|Firmicutes,24WG4@186801|Clostridia	186801|Clostridia	P	oxidoreductase, chain 4L	-	-	-	ko:K05567	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Oxidored_q2
k59_1626888_2	883169.HMPREF9719_01357	1.71e-20	94.4	COG1009@1|root,COG2111@1|root,COG1009@2|Bacteria,COG2111@2|Bacteria,2GIT4@201174|Actinobacteria,22JKT@1653|Corynebacteriaceae	201174|Actinobacteria	CP	NADH ubiquinone oxidoreductase subunit 5 (Chain L) Multisubunit Na H antiporter, MnhA subunit	mrpA/mrpB	-	-	ko:K05565,ko:K14086	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	DUF4040,MnhB,Proton_antipo_M,Proton_antipo_N
k59_1071501_1	1382359.JIAL01000001_gene2689	6.16e-162	481.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,3Y3NT@57723|Acidobacteria,2JIBK@204432|Acidobacteriia	204432|Acidobacteriia	EU	Dipeptidyl peptidase IV (DPP IV) N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	DPPIV_N,PD40,Peptidase_S9
k59_1071512_1	67352.JODS01000079_gene3548	3.99e-41	146.0	COG3547@1|root,COG3547@2|Bacteria,2GS79@201174|Actinobacteria	201174|Actinobacteria	L	Transposase IS116 IS110 IS902	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_960356_1	1163617.SCD_n01925	2.53e-75	238.0	COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,2VIP2@28216|Betaproteobacteria	28216|Betaproteobacteria	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
k59_1293681_1	384765.SIAM614_25851	2.28e-83	259.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,2TT2J@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	ammonium transporter'	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_960358_1	331869.BAL199_20345	4.76e-71	233.0	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2TQY9@28211|Alphaproteobacteria,4BR6A@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	TRAP transporter, 4TM 12TM fusion protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3394,DctM
k59_237947_1	351348.Maqu_0982	7.08e-130	389.0	COG3666@1|root,COG3666@2|Bacteria,1QW5T@1224|Proteobacteria,1T44C@1236|Gammaproteobacteria,46D6Z@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_1071546_1	1385517.N800_00720	6.27e-25	110.0	COG1361@1|root,COG3188@1|root,COG1361@2|Bacteria,COG3188@2|Bacteria,1R5G4@1224|Proteobacteria,1T61M@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Domain of unknown function DUF11	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
k59_348407_1	598659.NAMH_1231	1.31e-58	194.0	COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,42M5K@68525|delta/epsilon subdivisions,2YMJ2@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	F	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
k59_1626950_2	1504672.669783226	9.97e-07	53.9	COG0642@1|root,COG0745@1|root,COG3829@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,COG3829@2|Bacteria,1NRP8@1224|Proteobacteria,2WGNE@28216|Betaproteobacteria,4AGGJ@80864|Comamonadaceae	28216|Betaproteobacteria	T	His Kinase A (phospho-acceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
k59_348432_1	1502851.FG93_00182	1.96e-40	153.0	COG0642@1|root,COG2203@1|root,COG5002@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,2TX3Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,Hpt,Response_reg,dCache_1
k59_1405346_1	1455608.JDTH01000001_gene3281	1.19e-82	260.0	COG0174@1|root,arCOG01909@2157|Archaea,2XSYS@28890|Euryarchaeota,23SVV@183963|Halobacteria	183963|Halobacteria	E	glutamine synthetase	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
k59_1516338_1	595460.RRSWK_01024	9.08e-15	73.6	COG0715@1|root,COG0715@2|Bacteria,2J07J@203682|Planctomycetes	203682|Planctomycetes	P	Protein of unknown function (DUF3500)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3500
k59_404559_1	1267534.KB906758_gene2464	1.04e-65	223.0	COG0317@1|root,COG0317@2|Bacteria,3Y38Q@57723|Acidobacteria,2JIN0@204432|Acidobacteriia	204432|Acidobacteriia	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	-	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
k59_1683081_1	1218076.BAYB01000028_gene4608	5.73e-26	109.0	COG2982@1|root,COG2982@2|Bacteria,1NBZ0@1224|Proteobacteria,2VPGQ@28216|Betaproteobacteria,1K1QE@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Domain of Unknown Function (DUF748)	-	-	-	-	-	-	-	-	-	-	-	-	DUF748
k59_1461141_1	1207063.P24_16477	3.13e-180	513.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TSG6@28211|Alphaproteobacteria,2JQUU@204441|Rhodospirillales	204441|Rhodospirillales	C	FAD linked oxidases, C-terminal domain	glcD	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_404565_1	215803.DB30_3561	2.09e-100	305.0	COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,42MAR@68525|delta/epsilon subdivisions,2WJEU@28221|Deltaproteobacteria,2YWSR@29|Myxococcales	28221|Deltaproteobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_1071592_1	269799.Gmet_1935	1.89e-30	116.0	COG0142@1|root,COG0142@2|Bacteria,1MWNG@1224|Proteobacteria,42NPN@68525|delta/epsilon subdivisions,2WIY4@28221|Deltaproteobacteria,43U3I@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Polyprenyl synthetase	ispA	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K00795,ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00366	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
k59_1071592_2	330214.NIDE1520	2.62e-76	238.0	COG1562@1|root,COG1562@2|Bacteria,3J17J@40117|Nitrospirae	40117|Nitrospirae	I	Squalene/phytoene synthase	-	-	2.5.1.32,2.5.1.99	ko:K02291	ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110	M00097	R02065,R04218,R07270,R10177	RC00362,RC01101,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	SQS_PSY
k59_295171_1	575609.HMPREF0629_00964	1.12e-07	57.0	COG1493@1|root,COG1493@2|Bacteria,1TP5Z@1239|Firmicutes,24999@186801|Clostridia,22GC4@1570339|Peptoniphilaceae	186801|Clostridia	H	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion	hprK	-	-	ko:K06023	-	-	-	-	ko00000,ko01000	-	-	-	Hpr_kinase_C,Hpr_kinase_N
k59_1740359_2	1122609.AUGT01000002_gene3985	1.19e-15	77.8	COG0781@1|root,COG0781@2|Bacteria,2IM3D@201174|Actinobacteria,4DR4N@85009|Propionibacteriales	201174|Actinobacteria	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	GO:0008150,GO:0040007	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
k59_1573710_1	313606.M23134_01996	2.41e-43	154.0	COG0477@1|root,COG2814@2|Bacteria,4NEZT@976|Bacteroidetes,47M0X@768503|Cytophagia	976|Bacteroidetes	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1573710_2	1038860.AXAP01000017_gene2934	2.01e-06	49.7	COG1529@1|root,COG2010@1|root,COG1529@2|Bacteria,COG2010@2|Bacteria,1MV6D@1224|Proteobacteria,2TVYT@28211|Alphaproteobacteria,3K6MK@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	MA20_26525	-	1.17.2.1	ko:K18030	ko00760,ko01120,map00760,map01120	M00622	R09473	RC00589	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C2,Cytochrom_C,Cytochrome_CBB3
k59_1518034_1	1122604.JONR01000005_gene973	2.68e-11	68.2	COG4966@1|root,COG4966@2|Bacteria,1R5YK@1224|Proteobacteria,1RZIZ@1236|Gammaproteobacteria,1X8AT@135614|Xanthomonadales	135614|Xanthomonadales	NU	Type IV Pilus-assembly protein W	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl,PilW
k59_628024_1	1547437.LL06_01360	2.57e-29	115.0	COG0526@1|root,COG0526@2|Bacteria,1RI3N@1224|Proteobacteria,2TSEW@28211|Alphaproteobacteria,43H32@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	CO	periplasmic protein thiol disulfide	cycY	-	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	AhpC-TSA,Redoxin
k59_740239_1	1313265.JNIE01000002_gene795	3.84e-26	108.0	COG0296@1|root,COG0296@2|Bacteria	2|Bacteria	G	1,4-alpha-glucan branching enzyme activity	glgB	GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0055114,GO:0071704,GO:1901576	2.4.1.18,3.2.1.141	ko:K00700,ko:K01236	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110,R09995,R11256	RC00049	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
k59_740239_2	909663.KI867151_gene3004	1.54e-25	104.0	COG1449@1|root,COG1449@2|Bacteria,1PUYM@1224|Proteobacteria,42MQP@68525|delta/epsilon subdivisions,2WKP2@28221|Deltaproteobacteria,2MQ8B@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Belongs to the glycosyl hydrolase 57 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF3536,Glyco_hydro_57
k59_17436_1	1382306.JNIM01000001_gene441	5.36e-66	220.0	COG1884@1|root,COG1884@2|Bacteria,2G62T@200795|Chloroflexi	200795|Chloroflexi	I	TIGRFAM methylmalonyl-CoA mutase, large subunit	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
k59_517644_1	765420.OSCT_0695	4.89e-34	127.0	COG1129@1|root,COG1129@2|Bacteria,2GAI0@200795|Chloroflexi,377BP@32061|Chloroflexia	32061|Chloroflexia	G	ATPases associated with a variety of cellular activities	-	-	3.6.3.17	ko:K10545	ko02010,map02010	M00215	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.4	-	-	ABC_tran
k59_127564_1	1125863.JAFN01000001_gene2991	9.34e-61	196.0	COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,42NNQ@68525|delta/epsilon subdivisions,2WM2H@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM transposase IS116 IS110 IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_685096_1	685727.REQ_42460	9.31e-67	221.0	COG0493@1|root,COG1149@1|root,COG0493@2|Bacteria,COG1149@2|Bacteria,2GJ4A@201174|Actinobacteria,4FU0J@85025|Nocardiaceae	201174|Actinobacteria	E	4Fe-4S binding domain	-	-	1.18.1.2,1.19.1.1	ko:K00528	-	-	R10159	-	ko00000,ko01000	-	-	-	Fer4,Pyr_redox_2
k59_1407164_1	1123057.P872_24260	7.22e-48	170.0	COG1283@1|root,COG1283@2|Bacteria,4NHMY@976|Bacteroidetes,47NEB@768503|Cytophagia	976|Bacteroidetes	P	Na+/Pi-cotransporter	-	-	-	ko:K03324	-	-	-	-	ko00000,ko02000	2.A.58.2	-	-	Na_Pi_cotrans
k59_907470_1	251221.35210715	7.65e-76	235.0	COG3039@1|root,COG3039@2|Bacteria,1G1EK@1117|Cyanobacteria	1117|Cyanobacteria	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_3
k59_628067_1	402626.Rpic_4390	3.8e-57	198.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,2VHNJ@28216|Betaproteobacteria,1K4ZD@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_1351373_1	426117.M446_0171	9.05e-62	210.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria,1JTP3@119045|Methylobacteriaceae	1224|Proteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3,6.2.1.31,6.2.1.48	ko:K00666,ko:K01897,ko:K02182,ko:K16876,ko:K18661	ko00061,ko00071,ko00280,ko00365,ko01100,ko01120,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map00280,map00365,map01100,map01120,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280,R02986,R03383	RC00004,RC00014,RC00137,RC00174	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
k59_462729_1	1540257.JQMW01000009_gene3669	1.26e-08	55.5	COG0482@1|root,COG0482@2|Bacteria,1TPIZ@1239|Firmicutes,247YV@186801|Clostridia,36EFA@31979|Clostridiaceae	186801|Clostridia	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
k59_462729_2	1305732.JAGG01000001_gene2199	4.12e-20	92.4	COG1104@1|root,COG1104@2|Bacteria,2GKUT@201174|Actinobacteria,4FK4V@85023|Microbacteriaceae	201174|Actinobacteria	E	Aminotransferase class-V	iscS	GO:0003674,GO:0003824,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016226,GO:0016740,GO:0016782,GO:0016783,GO:0022607,GO:0031071,GO:0031163,GO:0040007,GO:0044085,GO:0044237,GO:0051186,GO:0071840	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
k59_1018525_1	269799.Gmet_3173	5.77e-55	185.0	COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,42MBH@68525|delta/epsilon subdivisions,2WJQV@28221|Deltaproteobacteria,43S19@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
k59_1073255_1	1123504.JQKD01000012_gene1372	2.72e-57	189.0	COG3384@1|root,COG3384@2|Bacteria,1PVHA@1224|Proteobacteria,2WBB4@28216|Betaproteobacteria,4AHWW@80864|Comamonadaceae	28216|Betaproteobacteria	S	Catalytic LigB subunit of aromatic ring-opening dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	LigB
k59_628074_2	986075.CathTA2_0912	7.53e-46	160.0	COG1073@1|root,COG1073@2|Bacteria,1V1RV@1239|Firmicutes,4HGDR@91061|Bacilli	91061|Bacilli	S	alpha beta	M1-904	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Hydrolase_4
k59_740279_1	83406.HDN1F_28220	3.2e-103	303.0	COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,1RMHX@1236|Gammaproteobacteria,1J513@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
k59_17479_1	1030157.AFMP01000008_gene3276	5.87e-58	193.0	COG0715@1|root,COG0715@2|Bacteria,1MWDN@1224|Proteobacteria,2TS0X@28211|Alphaproteobacteria,2K03R@204457|Sphingomonadales	204457|Sphingomonadales	P	Nitrate transporter	-	-	-	ko:K22067	-	-	-	-	ko00000,ko02022	-	-	-	NMT1_2
k59_685120_2	1499967.BAYZ01000069_gene1913	3.79e-72	229.0	COG0849@1|root,COG0849@2|Bacteria,2NNU2@2323|unclassified Bacteria	2|Bacteria	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	GO:0000166,GO:0003674,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008144,GO:0008150,GO:0009898,GO:0009987,GO:0016020,GO:0017076,GO:0030554,GO:0032153,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0051301,GO:0071944,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
k59_1018561_1	1232437.KL662001_gene4608	1.92e-46	170.0	COG1924@1|root,COG3580@1|root,COG3581@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,COG3581@2|Bacteria,1PKG6@1224|Proteobacteria,42MY4@68525|delta/epsilon subdivisions,2WJFI@28221|Deltaproteobacteria,2MIP0@213118|Desulfobacterales	28221|Deltaproteobacteria	I	BadF BadG BcrA BcrD	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229,HGD-D
k59_421259_1	247490.KSU1_B0100	2.8e-82	254.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4372
k59_478861_1	479434.Sthe_0337	2.9e-104	330.0	COG0060@1|root,COG0060@2|Bacteria,2G5SN@200795|Chloroflexi,27XEH@189775|Thermomicrobia	189775|Thermomicrobia	J	Anticodon-binding domain of tRNA	-	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
k59_810626_1	1260251.SPISAL_04045	5.48e-76	238.0	COG1559@1|root,COG1559@2|Bacteria,1MUQF@1224|Proteobacteria,1RMWD@1236|Gammaproteobacteria,1WWK3@135613|Chromatiales	135613|Chromatiales	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
k59_1478166_1	1124780.ANNU01000008_gene2769	1.07e-103	318.0	COG1164@1|root,COG1164@2|Bacteria,4NJFW@976|Bacteroidetes,47TFT@768503|Cytophagia	976|Bacteroidetes	E	Angiotensin-converting enzyme	-	-	3.4.15.1	ko:K01283	ko04614,ko04924,ko05142,ko05410,map04614,map04924,map05142,map05410	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	Peptidase_M2
k59_532435_1	1247963.JPHU01000001_gene2111	3.33e-103	316.0	COG4805@1|root,COG4805@2|Bacteria	2|Bacteria	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
k59_253932_1	1183438.GKIL_4031	1.21e-18	90.9	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_587483_1	497321.C664_01965	1.07e-48	177.0	COG3299@1|root,COG3299@2|Bacteria,1MWKI@1224|Proteobacteria,2VI5M@28216|Betaproteobacteria	28216|Betaproteobacteria	S	homolog of phage Mu protein gp47	-	-	-	-	-	-	-	-	-	-	-	-	Baseplate_J
k59_810664_1	1123399.AQVE01000001_gene724	1.14e-52	171.0	COG1941@1|root,COG1941@2|Bacteria,1NS0E@1224|Proteobacteria,1RW0G@1236|Gammaproteobacteria,461P0@72273|Thiotrichales	72273|Thiotrichales	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	-	-	1.12.1.2	ko:K18007	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_q6
k59_810664_2	857087.Metme_0247	2.65e-24	100.0	COG3259@1|root,COG3259@2|Bacteria,1QUQ7@1224|Proteobacteria,1T20U@1236|Gammaproteobacteria,1XDSA@135618|Methylococcales	135618|Methylococcales	C	Belongs to the NiFe NiFeSe hydrogenase large subunit family	-	-	1.12.1.2	ko:K00436	-	-	R00700	-	ko00000,ko01000	-	-	-	NiFeSe_Hases
k59_700270_1	935840.JAEQ01000001_gene3082	2.2e-59	194.0	COG0687@1|root,COG0687@2|Bacteria,1MUYW@1224|Proteobacteria,2TSUZ@28211|Alphaproteobacteria,43H41@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Required for the activity of the bacterial periplasmic transport system of putrescine	potF	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015695,GO:0015696,GO:0015846,GO:0015847,GO:0019808,GO:0019810,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043167,GO:0043169,GO:0044464,GO:0051179,GO:0051234,GO:0070405,GO:0071702,GO:0071705	-	ko:K11073	ko02010,map02010	M00300	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.2	-	-	SBP_bac_8
k59_700270_2	1144310.PMI07_003532	1.59e-29	114.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQMJ@28211|Alphaproteobacteria,4B8X7@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Part of the ABC transporter complex potABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	potA	GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015695,GO:0015696,GO:0015846,GO:0015847,GO:0016020,GO:0016021,GO:0031224,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351	-	ko:K11076	ko02010,map02010	M00300	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.2	-	-	ABC_tran,TOBE_2
k59_1034922_1	570967.JMLV01000003_gene2319	6.01e-85	263.0	COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,2TQU7@28211|Alphaproteobacteria,2JPGI@204441|Rhodospirillales	204441|Rhodospirillales	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
k59_1642796_1	439235.Dalk_2391	9.11e-55	189.0	COG1520@1|root,COG1520@2|Bacteria,1NYGT@1224|Proteobacteria,42TY0@68525|delta/epsilon subdivisions,2WQ74@28221|Deltaproteobacteria,2MKHR@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Arylsulfotransferase (ASST)	-	-	-	-	-	-	-	-	-	-	-	-	Arylsulfotran_2,Arylsulfotrans
k59_1311922_1	760192.Halhy_5470	1.51e-23	103.0	COG2801@1|root,COG2801@2|Bacteria,4NM64@976|Bacteroidetes,1IS2R@117747|Sphingobacteriia	976|Bacteroidetes	L	PFAM Integrase core domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	rve,rve_3
k59_810678_1	1294273.roselon_02595	9.79e-17	84.7	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,2TQZE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	COG0739 Membrane proteins related to metalloendopeptidases	MA20_30780	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_478926_1	1223545.GS4_08_01830	3.43e-61	211.0	COG0550@1|root,COG1754@1|root,COG0550@2|Bacteria,COG1754@2|Bacteria,2GJU7@201174|Actinobacteria,4GBZM@85026|Gordoniaceae	201174|Actinobacteria	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0009892,GO:0010605,GO:0016020,GO:0016853,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0032069,GO:0032074,GO:0040007,GO:0043086,GO:0043167,GO:0043169,GO:0044092,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060700,GO:0060701,GO:0065007,GO:0065009,GO:0071944,GO:0080090,GO:0140097	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,Toprim_C_rpt
k59_642522_1	1110502.TMO_1355	9.62e-68	223.0	COG5309@1|root,COG5309@2|Bacteria,1MWJJ@1224|Proteobacteria,2U19Q@28211|Alphaproteobacteria,2JQVV@204441|Rhodospirillales	204441|Rhodospirillales	G	beta (1-6) glucans synthase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_17
k59_142616_1	765869.BDW_01480	4.11e-81	247.0	COG1344@1|root,COG1344@2|Bacteria,1MV1N@1224|Proteobacteria,42MX8@68525|delta/epsilon subdivisions,2MTHE@213481|Bdellovibrionales,2WKE1@28221|Deltaproteobacteria	213481|Bdellovibrionales	N	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella	fliC	-	-	ko:K02406	ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_IN,Flagellin_N
k59_1478235_1	926569.ANT_28720	6.75e-113	328.0	COG0745@1|root,COG0745@2|Bacteria,2G5TG@200795|Chloroflexi	200795|Chloroflexi	K	Two component transcriptional regulator, winged helix family	-	-	-	ko:K07669	ko02020,map02020	M00460	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_978580_1	28444.JODQ01000006_gene916	4.74e-24	102.0	COG0667@1|root,COG0667@2|Bacteria,2GMNA@201174|Actinobacteria,4EGXG@85012|Streptosporangiales	201174|Actinobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_978580_2	76114.p2A120	5.73e-26	106.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria	1224|Proteobacteria	H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis	-	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
k59_1366893_1	1288826.MSNKSG1_14142	1.04e-54	185.0	COG0531@1|root,COG0531@2|Bacteria,1NCSX@1224|Proteobacteria,1RND7@1236|Gammaproteobacteria,4695V@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	Amino acid permease	yjeH	GO:0000099,GO:0000101,GO:0000102,GO:0001101,GO:0003333,GO:0003674,GO:0005215,GO:0005294,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0009719,GO:0009987,GO:0010033,GO:0010243,GO:0015075,GO:0015171,GO:0015175,GO:0015179,GO:0015191,GO:0015238,GO:0015291,GO:0015297,GO:0015318,GO:0015711,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015820,GO:0015821,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0043200,GO:0043865,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0070887,GO:0071229,GO:0071230,GO:0071310,GO:0071417,GO:0071495,GO:0071702,GO:0071705,GO:0071944,GO:0072348,GO:0098655,GO:0098656,GO:1901680,GO:1901682,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902475,GO:1903714,GO:1903785,GO:1903825,GO:1905039	-	ko:K03757,ko:K03759,ko:K16263	-	-	-	-	ko00000,ko02000	2.A.3.13,2.A.3.2	-	-	AA_permease_2
k59_1589060_1	344747.PM8797T_27719	2.89e-59	191.0	COG2197@1|root,COG2197@2|Bacteria,2IZND@203682|Planctomycetes	203682|Planctomycetes	K	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_587561_1	401053.AciPR4_2778	8.34e-14	76.3	COG0845@1|root,COG0845@2|Bacteria,3Y2XB@57723|Acidobacteria,2JI4U@204432|Acidobacteriia	204432|Acidobacteriia	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
k59_923997_1	450851.PHZ_c0606	1.24e-09	64.3	COG1597@1|root,COG1597@2|Bacteria,1MY37@1224|Proteobacteria,2TT5I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Diacylglycerol kinase	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
k59_923997_2	1144275.COCOR_07943	3.83e-26	103.0	COG0454@1|root,COG0456@2|Bacteria,1RD40@1224|Proteobacteria,43EF3@68525|delta/epsilon subdivisions,2X0ID@28221|Deltaproteobacteria,2Z1N2@29|Myxococcales	28221|Deltaproteobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_1034993_1	1519464.HY22_00520	1.96e-39	145.0	COG5621@1|root,COG5621@2|Bacteria	2|Bacteria	S	spheroidene biosynthetic process	attH	-	-	-	-	-	-	-	-	-	-	-	CrtC,Lipocalin_9
k59_1366904_1	1116472.MGMO_19c00080	8.41e-68	222.0	COG1004@1|root,COG1004@2|Bacteria	2|Bacteria	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
k59_1642853_1	1042376.AFPK01000045_gene2748	7.5e-07	49.7	COG0639@1|root,COG0639@2|Bacteria,4NEQW@976|Bacteroidetes,1HWXJ@117743|Flavobacteriia,406T7@61432|unclassified Flavobacteriaceae	976|Bacteroidetes	T	Calcineurin-like phosphoesterase superfamily domain	pphA	-	3.1.3.16	ko:K07313	-	-	-	-	ko00000,ko01000	-	-	-	Metallophos
k59_1642853_2	867845.KI911784_gene3189	5.15e-07	51.6	COG0607@1|root,COG0607@2|Bacteria	2|Bacteria	P	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_810771_1	926569.ANT_15910	8.89e-75	242.0	COG0481@1|root,COG0481@2|Bacteria,2G5K2@200795|Chloroflexi	200795|Chloroflexi	J	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C
k59_924034_1	1894.JOER01000005_gene2633	9.8e-86	268.0	COG0112@1|root,COG0112@2|Bacteria,2GK7U@201174|Actinobacteria	201174|Actinobacteria	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	-	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
k59_978629_1	1207063.P24_12811	2.23e-09	53.5	COG0255@1|root,COG0255@2|Bacteria,1N6PR@1224|Proteobacteria,2UF59@28211|Alphaproteobacteria,2JUAU@204441|Rhodospirillales	204441|Rhodospirillales	J	Belongs to the universal ribosomal protein uL29 family	rpmC	-	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
k59_978629_2	244581.IM40_02055	3.14e-76	229.0	COG0197@1|root,COG0197@2|Bacteria,1RA0Z@1224|Proteobacteria,2U710@28211|Alphaproteobacteria,47FB1@766|Rickettsiales	766|Rickettsiales	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	-	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
k59_1257159_1	406552.NJ7G_3851	7.89e-23	100.0	COG3119@1|root,arCOG02785@2157|Archaea,2XUB1@28890|Euryarchaeota,23TRP@183963|Halobacteria	183963|Halobacteria	P	COG3119 Arylsulfatase A and related enzymes	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_1422058_1	402881.Plav_2856	1.79e-103	305.0	COG2890@1|root,COG2890@2|Bacteria,1QWA6@1224|Proteobacteria,2TZBM@28211|Alphaproteobacteria,1JN9Z@119043|Rhodobiaceae	28211|Alphaproteobacteria	JM	ubiE/COQ5 methyltransferase family	-	-	2.1.1.156	ko:K18896	ko00260,map00260	-	R10060	RC00003,RC03038	ko00000,ko00001,ko01000	-	-	-	Methyltransf_25
k59_700395_1	985665.HPL003_07855	3.53e-60	202.0	COG1190@1|root,COG1190@2|Bacteria,1TP2P@1239|Firmicutes,4H9X4@91061|Bacilli,26R3F@186822|Paenibacillaceae	91061|Bacilli	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
k59_1756089_1	1121405.dsmv_1320	2.62e-67	226.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,42NDJ@68525|delta/epsilon subdivisions,2WJSH@28221|Deltaproteobacteria,2MIZ3@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_33704_1	1038866.KB902773_gene863	3.15e-44	164.0	COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TTJ0@28211|Alphaproteobacteria,3JS5D@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HAMP,HATPase_c,HisKA,PAS_7,dCache_1
k59_1480070_1	1379270.AUXF01000002_gene1577	2.49e-23	103.0	COG0515@1|root,COG5616@1|root,COG0515@2|Bacteria,COG5616@2|Bacteria,1ZUKV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
k59_255757_1	880072.Desac_2074	1.54e-161	464.0	COG0438@1|root,COG0438@2|Bacteria,1MYTB@1224|Proteobacteria,42MCA@68525|delta/epsilon subdivisions,2WJVX@28221|Deltaproteobacteria,2MQT9@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	PFAM Glycosyl transferases group 1	-	-	2.4.1.245	ko:K13057	ko00500,ko01100,map00500,map01100	-	R08946,R10525,R11306	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000	-	GT4	-	Glycos_transf_1
k59_423142_1	648757.Rvan_2588	5.8e-43	142.0	COG1917@1|root,COG1917@2|Bacteria,1MZNT@1224|Proteobacteria,2UCC4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	PFAM Cupin 2 conserved barrel domain protein	-	-	-	ko:K11312	-	-	-	-	ko00000	-	-	-	Cupin_2
k59_423142_2	222534.KB893713_gene2311	2.35e-25	99.0	COG0748@1|root,COG0748@2|Bacteria,2IN9W@201174|Actinobacteria	201174|Actinobacteria	P	F420H(2)-dependent quinone reductase	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
k59_980493_1	861299.J421_0393	1.49e-47	176.0	COG0577@1|root,COG0577@2|Bacteria	861299.J421_0393|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_480833_1	1121022.ABENE_23525	9.46e-39	139.0	COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,2KGFM@204458|Caulobacterales	204458|Caulobacterales	L	HTH-like domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
k59_480833_2	118173.KB235910_gene4661	8.54e-10	56.6	COG2963@1|root,COG2963@2|Bacteria,1GA7D@1117|Cyanobacteria,1HGED@1150|Oscillatoriales	1117|Cyanobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
k59_89437_1	644107.SL1157_A0044	1.55e-15	82.0	COG1626@1|root,COG1626@2|Bacteria,1QU4C@1224|Proteobacteria,2TSRJ@28211|Alphaproteobacteria,4ND81@97050|Ruegeria	28211|Alphaproteobacteria	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_63,Trehalase
k59_423173_2	379066.GAU_0578	5.71e-18	84.3	COG2204@1|root,COG2204@2|Bacteria,1ZSZ6@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1703372_1	926569.ANT_12290	6.05e-85	265.0	COG3464@1|root,COG3464@2|Bacteria,2G9B1@200795|Chloroflexi	200795|Chloroflexi	L	Transposase IS66 family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66
k59_144398_1	1158318.ATXC01000001_gene127	1.56e-11	68.2	COG0470@1|root,COG0470@2|Bacteria,2G57C@200783|Aquificae	200783|Aquificae	L	DNA polymerase III, delta subunit	-	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2
k59_144398_2	1304888.ATWF01000001_gene1309	8.03e-06	47.0	COG1162@1|root,COG1162@2|Bacteria	2|Bacteria	S	GTPase activity	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RNHCP,RsgA_GTPase
k59_1703376_2	1214101.BN159_6764	2.27e-06	51.2	COG0826@1|root,COG0826@2|Bacteria,2GKAK@201174|Actinobacteria	201174|Actinobacteria	O	peptidase U32	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1644540_1	1134474.O59_000129	1.83e-42	159.0	COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,1RMS3@1236|Gammaproteobacteria,1FG1C@10|Cellvibrio	1236|Gammaproteobacteria	CH	FAD binding domain	ubiH	GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008681,GO:0009058,GO:0009108,GO:0009314,GO:0009416,GO:0009628,GO:0009987,GO:0016491,GO:0016705,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0050896,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901576,GO:1901661,GO:1901663	-	ko:K03185,ko:K18800	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04987,R04989,R08768,R08773	RC00046,RC02670	ko00000,ko00001,ko00002,ko01000	-	-	iB21_1397.B21_02702,iECBD_1354.ECBD_0830,iECB_1328.ECB_02739,iECD_1391.ECD_02739,iEcHS_1320.EcHS_A3066	FAD_binding_3
k59_702226_1	1469245.JFBG01000010_gene599	3.67e-88	283.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,1T1JA@1236|Gammaproteobacteria,1X2PM@135613|Chromatiales	135613|Chromatiales	C	TIGRFAM formate dehydrogenase, alpha subunit	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_1258994_1	126957.SMAR004973-PA	1.2e-05	52.8	KOG4155@1|root,KOG4155@2759|Eukaryota,38F9N@33154|Opisthokonta,3BHBH@33208|Metazoa,3CX0Z@33213|Bilateria,41XJX@6656|Arthropoda	33208|Metazoa	S	U-box domain	WDSUB1	-	-	-	-	-	-	-	-	-	-	-	SAM_1,SAM_2,U-box,WD40
k59_1703387_1	485913.Krac_5673	4.45e-60	190.0	COG0262@1|root,COG0262@2|Bacteria,2G8UG@200795|Chloroflexi	200795|Chloroflexi	H	PFAM bifunctional deaminase-reductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
k59_866768_1	765420.OSCT_1127	4.8e-13	68.9	COG1185@1|root,COG1185@2|Bacteria,2G5TS@200795|Chloroflexi,374W6@32061|Chloroflexia	32061|Chloroflexia	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
k59_866768_2	1123389.ATXJ01000007_gene1731	1.89e-11	60.1	COG0184@1|root,COG0184@2|Bacteria,1WKC8@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
k59_866773_1	1484460.JSWG01000015_gene968	2.34e-104	318.0	COG1109@1|root,COG1109@2|Bacteria,4NFU7@976|Bacteroidetes,1HXUQ@117743|Flavobacteriia	976|Bacteroidetes	G	Phosphoglucomutase phosphomannomutase, alpha beta alpha domain II	pgcA	-	5.4.2.2	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00549	R00959,R01057,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_1591146_1	420662.Mpe_A3261	5.06e-74	234.0	COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,2W90Y@28216|Betaproteobacteria,1KP5D@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Aminotransferase class-V	-	-	2.6.1.37,2.6.1.44,2.6.1.45,2.6.1.51	ko:K00830,ko:K03430	ko00250,ko00260,ko00440,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00440,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	M00346,M00532	R00369,R00372,R00585,R00588,R04152	RC00006,RC00008,RC00018,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
k59_1756187_1	1380394.JADL01000001_gene2778	5.09e-100	302.0	COG4948@1|root,COG4948@2|Bacteria,1MVFW@1224|Proteobacteria,2TU7R@28211|Alphaproteobacteria,2JQRD@204441|Rhodospirillales	28211|Alphaproteobacteria	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	4.2.1.81	ko:K22209	-	-	-	-	ko00000,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
k59_1423913_1	1382306.JNIM01000001_gene1179	7.93e-10	60.5	COG0465@1|root,COG0465@2|Bacteria,2G5J3@200795|Chloroflexi	200795|Chloroflexi	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,Peptidase_M41
k59_1423913_2	693986.MOC_0466	1.36e-25	102.0	COG4126@1|root,COG4126@2|Bacteria,1Q1CD@1224|Proteobacteria,2TXDM@28211|Alphaproteobacteria,1JRSD@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	Asp/Glu/Hydantoin racemase	-	-	-	-	-	-	-	-	-	-	-	-	Asp_Glu_race
k59_423226_1	1007105.PT7_0069	5.32e-05	48.9	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2W1AD@28216|Betaproteobacteria,3T2J3@506|Alcaligenaceae	28216|Betaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_312958_1	948106.AWZT01000001_gene5077	8.57e-67	222.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,2WBWM@28216|Betaproteobacteria,1K6TM@119060|Burkholderiaceae	28216|Betaproteobacteria	H	3-octaprenyl-4-hydroxybenzoate carboxy-lyase	-	-	-	-	-	-	-	-	-	-	-	-	UbiD
k59_1147046_1	861299.J421_2404	2.93e-21	92.0	2DW4B@1|root,33YGG@2|Bacteria,1ZV12@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_702275_1	926569.ANT_01250	8.15e-137	395.0	COG0078@1|root,COG0078@2|Bacteria,2G7QE@200795|Chloroflexi	200795|Chloroflexi	E	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain	-	-	2.1.3.9	ko:K09065	ko00220,ko01100,ko01230,map00220,map01100,map01230	M00845	R07245	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_367296_1	65093.PCC7418_2890	1.47e-48	162.0	COG4803@1|root,COG4803@2|Bacteria,1G531@1117|Cyanobacteria	1117|Cyanobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF1269
k59_199838_2	237368.SCABRO_00954	3.41e-86	274.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_4
k59_33860_1	1411123.JQNH01000001_gene112	1.46e-19	85.9	COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,2TR11@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
k59_33860_2	883080.HMPREF9697_02479	1.26e-53	182.0	COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,2TQYK@28211|Alphaproteobacteria,3JRUG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
k59_89553_1	1267534.KB906757_gene967	2.69e-18	89.4	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_313003_1	251221.35211638	2.51e-25	107.0	COG1042@1|root,COG1670@1|root,COG1042@2|Bacteria,COG1670@2|Bacteria,1G2D3@1117|Cyanobacteria	1117|Cyanobacteria	CJ	TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain	-	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
k59_313003_2	1265313.HRUBRA_00544	6.22e-29	114.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,1RQUR@1236|Gammaproteobacteria,1J54K@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdZ	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Intein_splicing,LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN
k59_993915_1	259536.Psyc_1177	4.83e-26	112.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,1RP0K@1236|Gammaproteobacteria,3NIGC@468|Moraxellaceae	1236|Gammaproteobacteria	L	DNA polymerase	dnaE	GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032991,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0046483,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_656506_1	1123276.KB893246_gene558	9.64e-11	68.2	COG1629@1|root,COG4774@1|root,COG1629@2|Bacteria,COG4774@2|Bacteria,4PKAS@976|Bacteroidetes,47YFD@768503|Cytophagia	976|Bacteroidetes	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
k59_267847_1	502025.Hoch_1848	2.23e-67	211.0	COG0572@1|root,COG0572@2|Bacteria,1MWCH@1224|Proteobacteria,42T0E@68525|delta/epsilon subdivisions,2WPTV@28221|Deltaproteobacteria,2YUY9@29|Myxococcales	28221|Deltaproteobacteria	F	Phosphoribulokinase / Uridine kinase family	udk	-	2.7.1.19,2.7.1.48	ko:K00855,ko:K00876	ko00240,ko00710,ko00983,ko01100,ko01120,ko01200,map00240,map00710,map00983,map01100,map01120,map01200	M00165,M00166	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01523,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PRK
k59_1049819_1	1210046.B277_15714	0.000259	48.5	COG1721@1|root,COG1721@2|Bacteria,2GIWE@201174|Actinobacteria,4FGA2@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
k59_825627_1	1118054.CAGW01000053_gene1389	1.21e-09	62.8	COG2141@1|root,COG2141@2|Bacteria,1TRBN@1239|Firmicutes,4HBYT@91061|Bacilli,26W4T@186822|Paenibacillaceae	91061|Bacilli	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_46333_1	1122138.AQUZ01000004_gene889	1.18e-104	307.0	COG0479@1|root,COG0479@2|Bacteria,2GJPS@201174|Actinobacteria,4DPU6@85009|Propionibacteriales	201174|Actinobacteria	C	Succinate dehydrogenase fumarate reductase	sdhB	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_7,Fer4_8
k59_993943_1	351607.Acel_1004	1.2e-37	145.0	COG0768@1|root,COG0768@2|Bacteria,2GKHH@201174|Actinobacteria,4ERN7@85013|Frankiales	201174|Actinobacteria	M	Penicillin-binding protein, dimerisation domain	ftsI	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PBP_dimer,Transpeptidase
k59_381240_1	317936.Nos7107_4585	1.62e-78	246.0	COG2942@1|root,COG2942@2|Bacteria,1G04P@1117|Cyanobacteria,1HKN1@1161|Nostocales	1117|Cyanobacteria	G	PFAM N-acylglucosamine 2-epimerase	-	-	5.1.3.8	ko:K01787	ko00520,map00520	-	R01207	RC00290	ko00000,ko00001,ko01000	-	-	-	GlcNAc_2-epim
k59_1328191_1	886293.Sinac_1525	5.37e-51	172.0	COG2115@1|root,COG2115@2|Bacteria	2|Bacteria	G	xylose isomerase activity	-	-	5.3.1.5	ko:K01805	ko00040,ko00051,ko01100,map00040,map00051,map01100	-	R00878,R01432	RC00376,RC00516	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
k59_1161431_2	420247.Msm_1422	2.52e-43	147.0	COG1704@1|root,arCOG04574@2157|Archaea,2XX6E@28890|Euryarchaeota,23PYB@183925|Methanobacteria	183925|Methanobacteria	S	LemA family	-	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
k59_940049_1	1205683.CAKR01000037_gene337	5.99e-19	90.9	COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,1RME9@1236|Gammaproteobacteria,41F58@629|Yersinia	1236|Gammaproteobacteria	P	transporter of a GTP-driven Fe(2 ) uptake system	feoB	GO:0000041,GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005215,GO:0005381,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006826,GO:0006950,GO:0006974,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015093,GO:0015318,GO:0015684,GO:0016020,GO:0017076,GO:0019001,GO:0022857,GO:0022890,GO:0030001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0033554,GO:0034220,GO:0034755,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0044464,GO:0046873,GO:0046915,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0070838,GO:0071944,GO:0072509,GO:0072511,GO:0097159,GO:0097367,GO:0098655,GO:0098660,GO:0098662,GO:1901265,GO:1901363,GO:1903874	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	iECs_1301.ECs4251,iYL1228.KPN_03779	FeoB_C,FeoB_N,Gate
k59_1769847_1	697282.Mettu_0250	6.02e-85	269.0	COG0296@1|root,COG0296@2|Bacteria,1MVM7@1224|Proteobacteria,1RP2N@1236|Gammaproteobacteria,1XE30@135618|Methylococcales	135618|Methylococcales	G	TIGRFAM malto-oligosyltrehalose trehalohydrolase	-	-	3.2.1.141	ko:K01236	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11256	RC00049	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48,DUF3459
k59_547622_1	1379270.AUXF01000006_gene175	8.39e-53	176.0	COG1702@1|root,COG1702@2|Bacteria,1ZSSD@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	PhoH-like protein	-	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
k59_1382803_1	1283287.KB822579_gene2104	6.91e-13	69.3	COG2321@1|root,COG2321@2|Bacteria,2H3UT@201174|Actinobacteria,4DNNG@85009|Propionibacteriales	201174|Actinobacteria	S	Putative neutral zinc metallopeptidase	ypfJ	GO:0005575,GO:0005576	-	ko:K07054	-	-	-	-	ko00000	-	-	-	Zn_peptidase
k59_1382803_2	373994.Riv7116_1995	9.98e-24	99.0	COG2321@1|root,COG2321@2|Bacteria,1G20J@1117|Cyanobacteria,1HRR5@1161|Nostocales	1117|Cyanobacteria	S	Putative neutral zinc metallopeptidase	-	-	-	ko:K07054	-	-	-	-	ko00000	-	-	-	Zn_peptidase
k59_1214716_1	1129794.C427_1227	7.83e-59	194.0	COG1028@1|root,COG1028@2|Bacteria,1MUCH@1224|Proteobacteria,1RNAA@1236|Gammaproteobacteria,465UT@72275|Alteromonadaceae	1236|Gammaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_656574_1	1207063.P24_12537	3.41e-16	74.3	COG0824@1|root,COG0824@2|Bacteria,1RGZN@1224|Proteobacteria,2U95R@28211|Alphaproteobacteria,2JT13@204441|Rhodospirillales	204441|Rhodospirillales	S	Thioesterase-like superfamily	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
k59_656574_2	395019.Bmul_4949	2.86e-51	176.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VIFS@28216|Betaproteobacteria,1K04V@119060|Burkholderiaceae	28216|Betaproteobacteria	C	belongs to the aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
k59_1328232_1	596151.DesfrDRAFT_2298	7.94e-48	167.0	COG3177@1|root,COG3177@2|Bacteria,1MV69@1224|Proteobacteria,42MWV@68525|delta/epsilon subdivisions,2WJJZ@28221|Deltaproteobacteria,2MA8G@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	filamentation induced by cAMP protein Fic	-	-	-	-	-	-	-	-	-	-	-	-	Fic,Fic_N
k59_547636_1	234267.Acid_5465	4.47e-23	102.0	COG0577@1|root,COG0577@2|Bacteria,3Y6MX@57723|Acidobacteria	2|Bacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_212931_1	580327.Tthe_2694	1.32e-57	191.0	COG3547@1|root,COG3547@2|Bacteria,1TQP6@1239|Firmicutes,248VD@186801|Clostridia,42FT8@68295|Thermoanaerobacterales	186801|Clostridia	L	Transposase IS116 IS110 IS902 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_329413_1	42565.FP66_09540	5.08e-72	232.0	COG4623@1|root,COG4623@2|Bacteria,1MWDS@1224|Proteobacteria,1RM8W@1236|Gammaproteobacteria,1XI7H@135619|Oceanospirillales	135619|Oceanospirillales	M	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella	mltF	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944	-	ko:K18691	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	SBP_bac_3,SLT
k59_1330503_1	519989.ECTPHS_01354	1.28e-44	151.0	COG1952@1|root,COG1952@2|Bacteria,1RI75@1224|Proteobacteria,1S62H@1236|Gammaproteobacteria,1WY33@135613|Chromatiales	135613|Chromatiales	U	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA	secB	-	-	ko:K03071	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03110	3.A.5	-	-	SecB
k59_212940_1	767029.HMPREF9154_1536	2.85e-22	90.5	COG0756@1|root,COG0756@2|Bacteria,2IHYY@201174|Actinobacteria,4DQW7@85009|Propionibacteriales	201174|Actinobacteria	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
k59_1659990_1	1200792.AKYF01000010_gene1916	1.46e-53	185.0	COG0111@1|root,COG0111@2|Bacteria,1V410@1239|Firmicutes,4H9PH@91061|Bacilli,26QG6@186822|Paenibacillaceae	91061|Bacilli	E	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iYO844.BSU23070	2-Hacid_dh,2-Hacid_dh_C,ACT
k59_269230_1	1120985.AUMI01000020_gene1306	7.7e-16	82.0	COG1193@1|root,COG1193@2|Bacteria,1TP5W@1239|Firmicutes,4H2Z9@909932|Negativicutes	909932|Negativicutes	L	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_V,Smr
k59_995411_1	713586.KB900536_gene264	8.59e-70	220.0	COG2010@1|root,COG2010@2|Bacteria,1MV6D@1224|Proteobacteria,1RMYF@1236|Gammaproteobacteria,1WYQ3@135613|Chromatiales	135613|Chromatiales	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
k59_770634_2	1206731.BAGB01000062_gene7561	4e-37	135.0	COG3239@1|root,COG3239@2|Bacteria,2I8NB@201174|Actinobacteria,4G0AE@85025|Nocardiaceae	201174|Actinobacteria	I	Fatty acid desaturase	-	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase
k59_212962_1	498761.HM1_0679	2.38e-32	133.0	COG0037@1|root,COG0037@2|Bacteria,1TPXP@1239|Firmicutes,248TY@186801|Clostridia	186801|Clostridia	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS,TilS_C
k59_1275850_1	344747.PM8797T_23971	1.01e-73	234.0	COG0389@1|root,COG0389@2|Bacteria,2IZ2I@203682|Planctomycetes	203682|Planctomycetes	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
k59_1439125_1	180281.CPCC7001_1441	1.21e-65	220.0	COG4108@1|root,COG4108@2|Bacteria,1G0Y8@1117|Cyanobacteria,22S07@167375|Cyanobium	1117|Cyanobacteria	J	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP	prfC	-	-	ko:K02837	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,RF3_C
k59_1216128_1	1380390.JIAT01000010_gene3620	4.84e-54	172.0	COG0789@1|root,COG0789@2|Bacteria,2GKTU@201174|Actinobacteria,4CQ1W@84995|Rubrobacteria	84995|Rubrobacteria	K	MerR, DNA binding	-	-	-	ko:K13639	-	-	-	-	ko00000,ko03000	-	-	-	MerR,MerR-DNA-bind
k59_1051487_1	1122621.ATZA01000002_gene1701	5.71e-60	201.0	COG2234@1|root,COG2234@2|Bacteria,4NE66@976|Bacteroidetes,1IUY6@117747|Sphingobacteriia	976|Bacteroidetes	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
k59_160221_1	1197477.IA57_02160	1.35e-138	397.0	COG3396@1|root,COG3396@2|Bacteria,4NFJN@976|Bacteroidetes,1HXY6@117743|Flavobacteriia	976|Bacteroidetes	Q	With PaaBCDE catalyzes the hydroxylation of phenylacetyl-CoA	paaA	-	1.14.13.149	ko:K02609	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001,ko01000	-	-	-	PaaA_PaaC
k59_658194_1	309799.DICTH_0907	2.64e-09	57.4	COG0686@1|root,COG0686@2|Bacteria	2|Bacteria	E	alanine dehydrogenase activity	ald	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_1099	AlaDh_PNT_C,AlaDh_PNT_N
k59_658194_2	1283299.AUKG01000002_gene5179	6.52e-15	77.0	COG0612@1|root,COG0612@2|Bacteria,2GJZ3@201174|Actinobacteria,4CPQG@84995|Rubrobacteria	84995|Rubrobacteria	S	Belongs to the peptidase M16 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_1106278_1	1047013.AQSP01000076_gene1470	9.21e-76	243.0	COG3385@1|root,COG3385@2|Bacteria,2NRDU@2323|unclassified Bacteria	2|Bacteria	L	Transposase DDE domain group 1	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k59_827477_2	1120705.FG95_03243	1.27e-08	55.5	COG1801@1|root,COG1801@2|Bacteria,1MU7F@1224|Proteobacteria,2TT1D@28211|Alphaproteobacteria,2K8RV@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
k59_438090_1	926560.KE387023_gene3256	2.62e-24	95.9	COG2606@1|root,COG2606@2|Bacteria,1WJSU@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	YbaK prolyl-tRNA synthetase associated	ebsC	-	-	-	-	-	-	-	-	-	-	-	tRNA_edit
k59_438090_2	313606.M23134_02768	5.66e-13	66.2	COG0457@1|root,COG0457@2|Bacteria,4PBAK@976|Bacteroidetes,47VJ2@768503|Cytophagia	976|Bacteroidetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_941659_1	1226322.HMPREF1545_00749	1.44e-96	298.0	COG3547@1|root,COG3547@2|Bacteria,1TQ5G@1239|Firmicutes,247ME@186801|Clostridia,2N7E9@216572|Oscillospiraceae	186801|Clostridia	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1385068_1	1121920.AUAU01000004_gene661	4.84e-33	126.0	COG1071@1|root,COG1071@2|Bacteria,3Y4M3@57723|Acidobacteria	57723|Acidobacteria	C	Dehydrogenase E1 component	-	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
k59_1496607_1	1121405.dsmv_0651	1.47e-57	191.0	COG1060@1|root,COG1060@2|Bacteria,1MX50@1224|Proteobacteria,42M6U@68525|delta/epsilon subdivisions,2WJ6Y@28221|Deltaproteobacteria,2MJ4P@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnC	-	1.21.98.1	ko:K11784	ko00130,ko01110,map00130,map01110	-	R08588	RC02329	ko00000,ko00001,ko01000	-	-	-	Radical_SAM
k59_48200_1	237727.NAP1_06070	3.84e-31	123.0	COG2348@1|root,COG2348@2|Bacteria,1MXFY@1224|Proteobacteria,2TTYM@28211|Alphaproteobacteria,2K1U6@204457|Sphingomonadales	204457|Sphingomonadales	V	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_6
k59_1771604_1	1340493.JNIF01000003_gene4558	1.51e-49	168.0	COG1082@1|root,COG1082@2|Bacteria,3Y3CH@57723|Acidobacteria	57723|Acidobacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
k59_329585_2	196490.AUEZ01000010_gene2192	8.33e-19	85.9	COG0654@1|root,COG0654@2|Bacteria,1MUN4@1224|Proteobacteria,2TQT8@28211|Alphaproteobacteria,3JVYJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	CH	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
k59_496933_1	1047013.AQSP01000140_gene2486	5.4e-36	126.0	COG1051@1|root,COG1051@2|Bacteria,2NPYB@2323|unclassified Bacteria	2|Bacteria	F	NUDIX domain	-	-	1.1.1.169,3.1.3.25,3.6.1.55	ko:K00077,ko:K01092,ko:K03574	ko00521,ko00562,ko00770,ko01100,ko01110,ko04070,map00521,map00562,map00770,map01100,map01110,map04070	M00119,M00131	R01185,R01186,R01187,R02472	RC00078,RC00726	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	NUDIX
k59_496933_2	1121422.AUMW01000002_gene2280	2.27e-35	132.0	COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes,247NQ@186801|Clostridia,25ZZ5@186807|Peptococcaceae	186801|Clostridia	E	PFAM Aminotransferase class I and II	aspB	-	2.6.1.1	ko:K00812,ko:K10907	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	iHN637.CLJU_RS06550	Aminotran_1_2
k59_1660128_1	1191523.MROS_0644	9.9e-26	105.0	COG4799@1|root,COG4799@2|Bacteria	2|Bacteria	I	CoA carboxylase activity	mmdA	-	2.1.3.15,6.4.1.3,6.4.1.4	ko:K01966,ko:K01969	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00036,M00373,M00741	R01859,R04138	RC00097,RC00367,RC00609,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_1496669_1	1380394.JADL01000002_gene1140	3.18e-63	207.0	COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,2TQRI@28211|Alphaproteobacteria,2JQ0Y@204441|Rhodospirillales	204441|Rhodospirillales	H	COG0303 Molybdopterin biosynthesis enzyme	-	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
k59_1606134_2	342113.DM82_2021	2.59e-44	149.0	COG3556@1|root,COG3556@2|Bacteria,1N3XH@1224|Proteobacteria,2VRQ4@28216|Betaproteobacteria,1K72R@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Predicted membrane protein (DUF2214)	-	-	-	ko:K08983	-	-	-	-	ko00000	-	-	-	DUF2214
k59_718783_2	1410670.JHXF01000008_gene873	0.000177	43.9	COG1363@1|root,COG1363@2|Bacteria,1TNZT@1239|Firmicutes,248D0@186801|Clostridia,3WGHW@541000|Ruminococcaceae	186801|Clostridia	G	M42 glutamyl aminopeptidase	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Peptidase_M42
k59_496985_1	1120919.AUBI01000009_gene240	3.04e-10	67.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2TSN8@28211|Alphaproteobacteria,2JPTB@204441|Rhodospirillales	204441|Rhodospirillales	MU	Secretion system type I outer membrane efflux pump lipoprotein NodT	-	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_827572_1	1042375.AFPL01000031_gene805	8.71e-32	127.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,463YY@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	glnG	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_718795_1	1454004.AW11_01056	6.52e-81	258.0	COG0843@1|root,COG0843@2|Bacteria,1R57U@1224|Proteobacteria,2VJ1N@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Cytochrome C oxidase subunit I	cbaA	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_1660157_1	760192.Halhy_0690	8.2e-49	173.0	COG2273@1|root,COG2273@2|Bacteria,4NKMT@976|Bacteroidetes,1IW20@117747|Sphingobacteriia	976|Bacteroidetes	G	COG2273 Beta-glucanase Beta-glucan synthetase	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C,Glyco_hydro_16
k59_1163380_1	452637.Oter_0605	4.61e-55	195.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1144@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1144@2|Bacteria,46SAT@74201|Verrucomicrobia,3K7FK@414999|Opitutae	414999|Opitutae	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	-	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_603412_1	1123373.ATXI01000031_gene284	1.78e-12	74.3	COG0827@1|root,COG1002@1|root,COG0827@2|Bacteria,COG1002@2|Bacteria,2GI9C@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	LV	Type II restriction enzyme, methylase subunits	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1228474_1	1263831.F543_23760	4.73e-21	97.8	COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,1RP55@1236|Gammaproteobacteria,1Y7EN@135625|Pasteurellales	135625|Pasteurellales	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
k59_1672768_1	926569.ANT_11650	1.48e-87	270.0	COG1239@1|root,COG1239@2|Bacteria,2G832@200795|Chloroflexi	200795|Chloroflexi	H	SMART AAA ATPase	-	-	6.6.1.1	ko:K03405	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	-	Mg_chelatase
k59_1283585_1	324602.Caur_3745	2.15e-90	283.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
k59_1450571_1	861299.J421_1491	1.01e-92	289.0	COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1ZSZ7@142182|Gemmatimonadetes	142182|Gemmatimonadetes	CE	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_20,Fer4_7,Pyr_redox_2,Pyr_redox_3
k59_1450579_1	1144275.COCOR_07054	1.95e-24	103.0	COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,42URE@68525|delta/epsilon subdivisions,2WR5V@28221|Deltaproteobacteria,2YY8T@29|Myxococcales	28221|Deltaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_449842_1	1191523.MROS_1286	1.36e-80	264.0	COG2183@1|root,COG2183@2|Bacteria	2|Bacteria	K	obsolete transcription factor activity, core RNA polymerase II binding	yhgF	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010212,GO:0044424,GO:0044444,GO:0044464,GO:0050896	-	ko:K06959	-	-	-	-	ko00000	-	-	-	HHH_3,S1,Tex_N,Tex_YqgF
k59_5127_1	311403.Arad_7933	8.73e-51	179.0	COG0028@1|root,COG0028@2|Bacteria,1R859@1224|Proteobacteria,2UR7G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EH	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	-	-	-	-	-	-	-	-	-	-	TPP_enzyme_C,TPP_enzyme_N
k59_171705_1	1121904.ARBP01000018_gene2633	0.000356	48.5	COG0265@1|root,COG0265@2|Bacteria,4NFCS@976|Bacteroidetes,47KF5@768503|Cytophagia	976|Bacteroidetes	O	PDZ domain (Also known as DHR or GLGF)	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_1,PDZ_2,Trypsin_2
k59_1394690_1	159087.Daro_0152	9.64e-31	122.0	COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,2VRSM@28216|Betaproteobacteria,2KVQV@206389|Rhodocyclales	206389|Rhodocyclales	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	ko:K02849	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
k59_1394690_2	1121004.ATVC01000001_gene369	7.59e-08	53.1	COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,2VIBU@28216|Betaproteobacteria,2KS1B@206351|Neisseriales	206351|Neisseriales	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
k59_394111_1	1049564.TevJSym_ac01750	4.7e-125	360.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,1RM9U@1236|Gammaproteobacteria,1J5NQ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Polyphosphate kinase 2 (PPK2)	ppk2	-	2.7.4.1	ko:K22468	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PPK2
k59_1117089_2	290315.Clim_1055	3.18e-18	85.5	2EH9H@1|root,33B1D@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_229832_1	768671.ThimaDRAFT_2471	1.01e-84	263.0	COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,1RYPY@1236|Gammaproteobacteria,1X08U@135613|Chromatiales	135613|Chromatiales	S	Transposase zinc-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
k59_118257_1	479433.Caci_6264	6.97e-26	110.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,Trans_reg_C
k59_674636_1	1411123.JQNH01000001_gene1153	1.18e-84	263.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,2TSCR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	glutamine synthetase	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
k59_1285953_1	935836.JAEL01000010_gene3735	3.3e-16	80.1	COG1178@1|root,COG1178@2|Bacteria,1TPMX@1239|Firmicutes,4HA2U@91061|Bacilli,1ZQER@1386|Bacillus	91061|Bacilli	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
k59_118264_1	391937.NA2_00865	1.34e-42	147.0	COG0559@1|root,COG0559@2|Bacteria,1QDNH@1224|Proteobacteria,2U1CJ@28211|Alphaproteobacteria,43NX1@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	U	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_118264_2	1380355.JNIJ01000021_gene3716	2.95e-84	259.0	COG0683@1|root,COG0683@2|Bacteria,1NNXR@1224|Proteobacteria,2VEZD@28211|Alphaproteobacteria,3K6E7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Receptor family ligand binding region	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
k59_229844_1	1122611.KB903948_gene6718	3.87e-25	111.0	COG0577@1|root,COG0577@2|Bacteria,2H997@201174|Actinobacteria,4EGB7@85012|Streptosporangiales	201174|Actinobacteria	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX
k59_1231225_1	404589.Anae109_2239	1.56e-72	231.0	COG1875@1|root,COG1875@2|Bacteria,1MUX1@1224|Proteobacteria,42MK9@68525|delta/epsilon subdivisions,2WJ1C@28221|Deltaproteobacteria,2YY78@29|Myxococcales	28221|Deltaproteobacteria	T	Large family of predicted nucleotide-binding domains	phoH1	-	-	ko:K07175	-	-	-	-	ko00000	-	-	-	PIN_4,PhoH
k59_340683_2	1235794.C811_00630	1.01e-17	82.0	COG0319@1|root,COG0319@2|Bacteria,2GMUF@201174|Actinobacteria,4CVZI@84998|Coriobacteriia	84998|Coriobacteriia	S	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	UPF0054
k59_897102_1	1499967.BAYZ01000028_gene1307	7.97e-97	296.0	COG4177@1|root,COG4177@2|Bacteria,2NPMP@2323|unclassified Bacteria	2|Bacteria	U	Branched-chain amino acid transport system / permease component	livM	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_7573_1	666685.R2APBS1_1312	5.5e-36	135.0	COG4709@1|root,COG4709@2|Bacteria,1NX5K@1224|Proteobacteria,1SPS6@1236|Gammaproteobacteria,1X34I@135614|Xanthomonadales	135614|Xanthomonadales	S	Putative sensor	-	-	-	-	-	-	-	-	-	-	-	-	Sensor
k59_229870_1	391735.Veis_3321	1.39e-63	216.0	COG1042@1|root,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2VI9R@28216|Betaproteobacteria,4AAAJ@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM CoA-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,Acetyltransf_3,Acetyltransf_4,CoA_binding_2,Succ_CoA_lig
k59_340685_3	1089552.KI911559_gene873	1.99e-26	99.4	COG0073@1|root,COG0073@2|Bacteria,1RGU7@1224|Proteobacteria,2U9AH@28211|Alphaproteobacteria,2JT0T@204441|Rhodospirillales	204441|Rhodospirillales	J	Putative tRNA binding domain	-	-	-	ko:K06878	-	-	-	-	ko00000	-	-	-	tRNA_bind
k59_285436_1	113395.AXAI01000015_gene390	2.64e-13	73.2	COG1716@1|root,COG1716@2|Bacteria,1MXT7@1224|Proteobacteria,2U0R7@28211|Alphaproteobacteria,3JRHD@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Inner membrane component of T3SS, cytoplasmic domain	-	-	-	-	-	-	-	-	-	-	-	-	Yop-YscD_cpl
k59_1008225_1	526222.Desal_2337	1.18e-48	164.0	COG1272@1|root,COG1272@2|Bacteria,1PGRH@1224|Proteobacteria,42SPM@68525|delta/epsilon subdivisions,2WMYY@28221|Deltaproteobacteria,2MAFZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	TIGRFAM channel protein, hemolysin III family	-	-	-	ko:K11068	-	-	-	-	ko00000,ko02042	-	-	-	HlyIII
k59_396495_1	1123253.AUBD01000001_gene1898	2.79e-42	157.0	COG0460@1|root,COG0527@1|root,COG0460@2|Bacteria,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,1RN1G@1236|Gammaproteobacteria,1X4R3@135614|Xanthomonadales	135614|Xanthomonadales	E	homoserine dehydrogenase	thrA	-	1.1.1.3,2.7.2.4	ko:K12524	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00017,M00018,M00526,M00527	R00480,R01773,R01775	RC00002,RC00043,RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7,Homoserine_dh,NAD_binding_3
k59_452328_2	42256.RradSPS_0863	3.63e-28	114.0	COG1459@1|root,COG1459@2|Bacteria,2GQW0@201174|Actinobacteria,4CPUI@84995|Rubrobacteria	84995|Rubrobacteria	NU	COG COG1459 Type II secretory pathway component PulF Cell motility and secretion Intracellular trafficking and secretion	-	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
k59_507759_1	1123501.KB902294_gene3529	3.19e-65	219.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TVI3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctA
k59_897138_1	880072.Desac_0786	2.14e-10	67.4	COG4962@1|root,COG4962@2|Bacteria,1R7EN@1224|Proteobacteria,42NAK@68525|delta/epsilon subdivisions,2WIYX@28221|Deltaproteobacteria,2MQ42@213462|Syntrophobacterales	28221|Deltaproteobacteria	U	PFAM Type II secretion system protein E	-	-	-	ko:K02283,ko:K03609	-	-	-	-	ko00000,ko02035,ko02044,ko03036,ko04812	-	-	-	CbiA,FHA,T2SSE
k59_229905_2	1220534.B655_0176	1.47e-46	167.0	COG1950@1|root,arCOG09731@2157|Archaea,2Y2F9@28890|Euryarchaeota,23PAN@183925|Methanobacteria	183925|Methanobacteria	S	Mycobacterial 4 TMS phage holin, superfamily IV	-	-	-	-	-	-	-	-	-	-	-	-	Phage_holin_4_2,Phosphodiest
k59_1397233_1	1121927.GOHSU_23_00320	0.00058	45.8	COG0261@1|root,COG0261@2|Bacteria,2HXCU@201174|Actinobacteria,4GFCT@85026|Gordoniaceae	201174|Actinobacteria	J	This protein binds to 23S rRNA in the presence of protein L20	-	-	-	-	-	-	-	-	-	-	-	-	Rho_N
k59_118331_1	999541.bgla_2g27330	8.56e-48	166.0	COG0323@1|root,COG0323@2|Bacteria,1R57G@1224|Proteobacteria,2VP7W@28216|Betaproteobacteria,1K86N@119060|Burkholderiaceae	28216|Betaproteobacteria	L	DNA mismatch repair	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_3
k59_174116_1	1366050.N234_01395	1.16e-56	196.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2VM2H@28216|Betaproteobacteria,1K0UN@119060|Burkholderiaceae	28216|Betaproteobacteria	L	helicase	pcrA	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_841079_1	909663.KI867150_gene2628	3.93e-94	298.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,2MR70@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_1453135_1	1379270.AUXF01000002_gene1577	9.07e-85	273.0	COG0515@1|root,COG5616@1|root,COG0515@2|Bacteria,COG5616@2|Bacteria,1ZUKV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
k59_1341648_1	56780.SYN_00558	3.19e-99	307.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,42N1K@68525|delta/epsilon subdivisions,2WIT6@28221|Deltaproteobacteria,2MQAG@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
k59_897168_2	1280954.HPO_16555	0.000649	45.4	COG1309@1|root,COG1309@2|Bacteria,1N6JM@1224|Proteobacteria,2UU8Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_1675239_1	80884.CCF34976	7.23e-52	170.0	COG1986@1|root,2S3KM@2759|Eukaryota,3A77F@33154|Opisthokonta,3PFNG@4751|Fungi,3R36W@4890|Ascomycota,21A3K@147550|Sordariomycetes,1EUAU@1028384|Glomerellales	4751|Fungi	F	Protein of unknown function DUF84	-	-	-	-	-	-	-	-	-	-	-	-	NTPase_I-T
k59_1453152_1	979556.MTES_1774	3.52e-33	127.0	COG0402@1|root,COG0402@2|Bacteria,2GZ2Q@201174|Actinobacteria,4FNUB@85023|Microbacteriaceae	201174|Actinobacteria	F	Amidohydrolase family	hutF	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_396535_2	1120965.AUBV01000015_gene1119	8.54e-18	82.0	COG3222@1|root,COG3222@2|Bacteria,4NM7F@976|Bacteroidetes,47PF2@768503|Cytophagia	976|Bacteroidetes	S	protein conserved in bacteria	-	-	-	ko:K09931	-	-	-	-	ko00000	-	-	-	DUF2064
k59_7649_1	1416760.AYMS01000051_gene190	0.00013	49.3	COG3547@1|root,COG3547@2|Bacteria,4NIKY@976|Bacteroidetes,1HZCU@117743|Flavobacteriia	976|Bacteroidetes	L	Transposase IS116 IS110 IS902	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1008294_1	1033802.SSPSH_001271	8.38e-55	181.0	COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,1RMBI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	GO:0003674,GO:0003824,GO:0004857,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0006979,GO:0008150,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030234,GO:0043021,GO:0043022,GO:0043023,GO:0043086,GO:0044092,GO:0044424,GO:0044464,GO:0044877,GO:0050790,GO:0050896,GO:0065007,GO:0065009,GO:0098772	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
k59_1619425_2	984962.XP_009552086.1	5.7e-05	47.4	COG1063@1|root,KOG0024@2759|Eukaryota,38I3Q@33154|Opisthokonta,3NZVH@4751|Fungi,3UZ4S@5204|Basidiomycota,22BHV@155619|Agaricomycetes,3H716@355688|Agaricomycetes incertae sedis	4751|Fungi	Q	Glucose dehydrogenase C-terminus	-	-	1.1.1.287	ko:K17818	ko00040,ko01100,map00040,map01100	-	R07143,R07144	RC00102	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N,Glu_dehyd_C
k59_952415_11	28152.DJ57_2550	3.9e-140	434.0	28JKJ@1|root,2Z9DD@2|Bacteria,1MUN2@1224|Proteobacteria,1RQIP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Phage P22-like portal protein	-	-	-	-	-	-	-	-	-	-	-	-	P22_portal
k59_952415_12	1121921.KB898706_gene3039	1.69e-107	335.0	COG1783@1|root,COG1783@2|Bacteria,1R66A@1224|Proteobacteria,1RQFD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Phage terminase, large subunit	Z012_12305	-	-	ko:K06909	-	-	-	-	ko00000	-	-	-	Terminase_3,Terminase_3C
k59_952415_22	1122970.AUHC01000022_gene2495	2.08e-15	71.6	2E7GT@1|root,331ZH@2|Bacteria,1NAHD@1224|Proteobacteria,2UHC5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_952415_25	411154.GFO_2454	4.67e-81	254.0	COG0175@1|root,COG0175@2|Bacteria,4NIGW@976|Bacteroidetes,1I12Z@117743|Flavobacteriia	976|Bacteroidetes	EH	sulfate reduction	-	-	-	-	-	-	-	-	-	-	-	-	PAPS_reduct
k59_952415_30	1122201.AUAZ01000021_gene3141	5.99e-44	153.0	COG1403@1|root,COG1403@2|Bacteria,1RHFB@1224|Proteobacteria,1S4HW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	NinG protein	-	-	-	-	-	-	-	-	-	-	-	-	NinG
k59_1690892_1	1340493.JNIF01000004_gene171	1.74e-87	264.0	COG1209@1|root,COG1209@2|Bacteria,3Y2ZJ@57723|Acidobacteria	57723|Acidobacteria	M	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
k59_913611_1	1278073.MYSTI_07720	1.45e-50	174.0	COG0534@1|root,COG0534@2|Bacteria,1MVRV@1224|Proteobacteria,42QG6@68525|delta/epsilon subdivisions,2WNNB@28221|Deltaproteobacteria,2YUAE@29|Myxococcales	28221|Deltaproteobacteria	V	MatE	-	-	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
k59_1249562_1	1137281.D778_01933	1.76e-14	72.4	COG0373@1|root,COG0373@2|Bacteria,4NFTY@976|Bacteroidetes,1HX42@117743|Flavobacteriia	976|Bacteroidetes	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
k59_1249562_2	1121912.AUHD01000008_gene28	4.51e-72	231.0	COG0181@1|root,COG1587@1|root,COG0181@2|Bacteria,COG1587@2|Bacteria,4NHH4@976|Bacteroidetes,1HXKZ@117743|Flavobacteriia	976|Bacteroidetes	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	-	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4,Porphobil_deam,Porphobil_deamC
k59_80117_1	768066.HELO_1899	5.91e-41	140.0	COG1905@1|root,COG1905@2|Bacteria,1RHBU@1224|Proteobacteria,1S779@1236|Gammaproteobacteria,1XS6W@135619|Oceanospirillales	135619|Oceanospirillales	C	Thioredoxin-like [2Fe-2S] ferredoxin	-	-	-	ko:K00127	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	2Fe-2S_thioredx
k59_1470538_1	861299.J421_2767	2.16e-77	259.0	COG0085@1|root,COG0085@2|Bacteria,1ZSQH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_970394_1	224325.AF_0130	3e-61	201.0	COG0123@1|root,arCOG00324@2157|Archaea,2XT0B@28890|Euryarchaeota,246V5@183980|Archaeoglobi	183980|Archaeoglobi	BQ	PFAM histone deacetylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
k59_1693104_1	1469607.KK073769_gene6074	1.85e-84	260.0	COG3293@1|root,COG3293@2|Bacteria,1G0BW@1117|Cyanobacteria,1HNSC@1161|Nostocales	1117|Cyanobacteria	L	transposase	-	-	-	ko:K07492	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
k59_857381_1	926569.ANT_12110	8.47e-60	201.0	COG0739@1|root,COG1388@1|root,COG0739@2|Bacteria,COG1388@2|Bacteria	2|Bacteria	M	LysM domain	-	-	2.7.7.6	ko:K03046,ko:K03641,ko:K08642	ko00230,ko00240,ko01100,ko02024,ko03020,map00230,map00240,map01100,map02024,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko01002,ko02000,ko03021,ko03400	2.C.1.2	-	-	Glyco_hydro_18,LysM,OapA,PD40,Peptidase_M23
k59_1359150_1	1150469.RSPPHO_01870	1.46e-56	198.0	COG1215@1|root,COG5309@1|root,COG1215@2|Bacteria,COG5309@2|Bacteria,1MWF8@1224|Proteobacteria,2VEZT@28211|Alphaproteobacteria,2JR2N@204441|Rhodospirillales	204441|Rhodospirillales	M	Glycosyl transferase family group 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_17,Glyco_tranf_2_3,Glyco_trans_2_3
k59_857385_1	706587.Desti_2465	2.18e-58	204.0	COG0243@1|root,COG1104@1|root,COG0243@2|Bacteria,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,42M5V@68525|delta/epsilon subdivisions,2WIR6@28221|Deltaproteobacteria,2MQ79@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine	nifS-2	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5,Molybdopterin,Molydop_binding
k59_135343_1	379066.GAU_3001	2.24e-36	138.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,1ZUC3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
k59_579934_1	1244869.H261_14625	4.89e-65	209.0	COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,2TRQA@28211|Alphaproteobacteria,2JPTV@204441|Rhodospirillales	204441|Rhodospirillales	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
k59_692355_1	1000565.METUNv1_04052	1.56e-110	329.0	COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,2VHW4@28216|Betaproteobacteria,2KURW@206389|Rhodocyclales	206389|Rhodocyclales	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
k59_1525708_2	1123251.ATWM01000002_gene221	5.02e-05	50.1	COG0079@1|root,COG0079@2|Bacteria,2GJ9W@201174|Actinobacteria,4FFMU@85021|Intrasporangiaceae	201174|Actinobacteria	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_1693145_1	178306.PAE2861	0.000521	47.8	COG3301@1|root,arCOG02027@2157|Archaea	2157|Archaea	P	PFAM Polysulphide reductase, NrfD	-	-	-	ko:K04015	-	-	-	-	ko00000	-	-	-	NrfD
k59_692368_1	324602.Caur_0549	1.16e-46	164.0	COG2128@1|root,COG2128@2|Bacteria,2G7WP@200795|Chloroflexi,376HC@32061|Chloroflexia	32061|Chloroflexia	S	Protein of unknown function (DUF3179)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3179
k59_135382_1	1379270.AUXF01000003_gene3859	4.81e-47	164.0	COG1260@1|root,COG1260@2|Bacteria,1ZT2X@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Myo-inositol-1-phosphate synthase	-	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth,NAD_binding_5
k59_1581464_1	710243.XP_007594630.1	1.87e-08	60.1	COG1282@1|root,2QQ0A@2759|Eukaryota,38CB0@33154|Opisthokonta,3NYXQ@4751|Fungi,3QKYV@4890|Ascomycota,21582@147550|Sordariomycetes,1EW13@1028384|Glomerellales	4751|Fungi	C	NAD(P) transhydrogenase	-	-	1.6.1.2	ko:K00323	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N,PNTB,PNTB_4TM
k59_1414530_1	700598.Niako_6344	1.76e-65	212.0	COG1271@1|root,COG1271@2|Bacteria,4NG7U@976|Bacteroidetes,1IP9E@117747|Sphingobacteriia	976|Bacteroidetes	C	Cytochrome bd ubiquinol oxidase subunit I	cydA	-	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_I
k59_1303660_1	316056.RPC_3288	4.17e-47	169.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,2TSR0@28211|Alphaproteobacteria,3JUVV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Flavin containing amine oxidoreductase	MA20_01895	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
k59_1470611_1	926569.ANT_01220	2.74e-74	241.0	COG1001@1|root,COG1001@2|Bacteria,2G64P@200795|Chloroflexi	200795|Chloroflexi	F	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family	ade	-	3.5.4.2	ko:K01486	ko00230,ko01100,map00230,map01100	-	R01244	RC00477	ko00000,ko00001,ko01000	-	-	-	Adenine_deam_C,Amidohydro_1
k59_302872_1	443255.SCLAV_1700	2.46e-08	57.8	COG1121@1|root,COG1121@2|Bacteria,2GP3A@201174|Actinobacteria	201174|Actinobacteria	P	ABC transporter	mntB	-	-	ko:K09817	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC_tran
k59_579982_2	1121448.DGI_2607	0.000381	43.9	COG0517@1|root,COG0517@2|Bacteria,1RA25@1224|Proteobacteria,42R80@68525|delta/epsilon subdivisions,2WMW6@28221|Deltaproteobacteria,2MARF@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM CBS domain containing protein	-	-	-	ko:K04767	-	-	-	-	ko00000	-	-	-	CBS
k59_1026606_1	326427.Cagg_0668	8.52e-09	62.0	COG5184@1|root,COG5184@2|Bacteria,2G8WU@200795|Chloroflexi,3765G@32061|Chloroflexia	200795|Chloroflexi	DZ	PFAM regulator of chromosome condensation, RCC1	-	-	-	-	-	-	-	-	-	-	-	-	RCC1,RCC1_2
k59_1026610_1	1297863.APJF01000005_gene1852	3.35e-23	90.9	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,2UF6W@28211|Alphaproteobacteria,3K03T@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	'Cold-shock' DNA-binding domain	MA20_05565	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
k59_1693193_1	1541065.JRFE01000025_gene1983	1.13e-05	47.0	COG3265@1|root,COG3265@2|Bacteria,1G60D@1117|Cyanobacteria,3VK3G@52604|Pleurocapsales	1117|Cyanobacteria	G	Shikimate kinase	gntK	-	2.7.1.12	ko:K00851	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	-	R01737	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	SKI
k59_1693193_2	1120998.AUFC01000002_gene2799	5.19e-16	79.0	COG0524@1|root,COG0524@2|Bacteria,1TQRC@1239|Firmicutes,249QQ@186801|Clostridia,3WD6T@538999|Clostridiales incertae sedis	186801|Clostridia	G	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway	rbsK	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
k59_1249652_1	1469607.KK073768_gene3963	5.92e-18	78.6	COG0102@1|root,COG0102@2|Bacteria,1G512@1117|Cyanobacteria,1HN1X@1161|Nostocales	1117|Cyanobacteria	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
k59_1249652_2	558173.CDOO_03100	4.89e-25	100.0	COG0103@1|root,COG0103@2|Bacteria,2GNDY@201174|Actinobacteria,22KYK@1653|Corynebacteriaceae	201174|Actinobacteria	J	Belongs to the universal ribosomal protein uS9 family	rpsI	GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
k59_24966_1	1041139.KB902724_gene3997	2.44e-14	74.3	COG3616@1|root,COG3616@2|Bacteria,1MVQE@1224|Proteobacteria,2TSQ3@28211|Alphaproteobacteria,4B9GX@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	amino acid aldolase or racemase	MA20_27460	-	-	-	-	-	-	-	-	-	-	-	Ala_racemase_N,D-ser_dehydrat
k59_747627_1	382640.BT_1197	3.3e-10	65.9	COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,2TR2H@28211|Alphaproteobacteria,48TGP@772|Bartonellaceae	28211|Alphaproteobacteria	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_525186_1	64471.sync_1460	1.57e-39	147.0	COG3424@1|root,COG3424@2|Bacteria,1G098@1117|Cyanobacteria,1GZ25@1129|Synechococcus	1117|Cyanobacteria	Q	synthase	-	-	-	ko:K16167,ko:K16233	-	-	-	-	ko00000,ko01008	-	-	-	Chal_sti_synt_C,Chal_sti_synt_N,FAE1_CUT1_RppA
k59_246846_1	1042375.AFPL01000022_gene2525	7.53e-21	91.3	COG0688@1|root,COG0688@2|Bacteria,1MVT4@1224|Proteobacteria,1RN1U@1236|Gammaproteobacteria,4656J@72275|Alteromonadaceae	1236|Gammaproteobacteria	I	Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)	psd	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
k59_246848_1	667014.Thein_0956	1.12e-22	99.4	COG1409@1|root,COG1409@2|Bacteria,2GI8F@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
k59_246848_2	1038859.AXAU01000008_gene2066	3.89e-26	99.4	COG0346@1|root,COG0346@2|Bacteria,1RH79@1224|Proteobacteria,2UAPG@28211|Alphaproteobacteria,3JYFP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	MA20_43515	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
k59_302932_1	1207063.P24_00445	8.78e-78	239.0	COG2833@1|root,COG2833@2|Bacteria,1MW0V@1224|Proteobacteria,2TQJU@28211|Alphaproteobacteria,2JPH7@204441|Rhodospirillales	204441|Rhodospirillales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF455
k59_857493_1	717231.Flexsi_1835	7.96e-30	117.0	COG0616@1|root,COG0616@2|Bacteria,2GFM0@200930|Deferribacteres	200930|Deferribacteres	OU	Peptidase family S49	-	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
k59_915761_2	926569.ANT_06490	2.55e-62	198.0	COG1083@1|root,COG1083@2|Bacteria	2|Bacteria	M	cytidylyl-transferase	-	-	2.7.7.43	ko:K00983	ko00520,ko01100,map00520,map01100	-	R01117,R04215	RC00152	ko00000,ko00001,ko01000	-	-	-	CTP_transf_3,RraA-like
k59_1525820_1	1232443.BAIA02000098_gene3463	1.89e-07	51.2	COG2172@1|root,COG2172@2|Bacteria,1VAPM@1239|Firmicutes,24J9J@186801|Clostridia	186801|Clostridia	T	Histidine kinase-like ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2
k59_1635900_1	1121035.AUCH01000013_gene3087	7.4e-119	371.0	COG0842@1|root,COG1129@1|root,COG0842@2|Bacteria,COG1129@2|Bacteria,1QTT9@1224|Proteobacteria,2WGGY@28216|Betaproteobacteria,2KVF7@206389|Rhodocyclales	206389|Rhodocyclales	V	ABC-type multidrug transport system, ATPase component	-	-	-	ko:K13926	-	-	-	-	ko00000	-	-	-	ABC2_membrane_3,ABC_tran
k59_747673_1	1167006.UWK_00067	5.39e-56	186.0	COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,42KZG@68525|delta/epsilon subdivisions,2WIQ5@28221|Deltaproteobacteria,2MIKI@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Belongs to the CarA family	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
k59_1581573_1	926569.ANT_22970	1.79e-70	233.0	COG0531@1|root,COG0531@2|Bacteria,2G5ZF@200795|Chloroflexi	200795|Chloroflexi	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
k59_692497_1	1487923.DP73_07390	8.07e-16	75.5	COG2197@1|root,COG2197@2|Bacteria,1VV36@1239|Firmicutes,2508S@186801|Clostridia,2651R@186807|Peptococcaceae	186801|Clostridia	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_191250_1	314230.DSM3645_02358	1.03e-51	183.0	COG1529@1|root,COG1529@2|Bacteria,2IYIN@203682|Planctomycetes	203682|Planctomycetes	C	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL	-	-	1.17.1.4	ko:K11177	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_803310_1	1242864.D187_002863	1.5e-28	118.0	COG0318@1|root,COG1020@1|root,COG0318@2|Bacteria,COG1020@2|Bacteria,1MU6G@1224|Proteobacteria,43C6Z@68525|delta/epsilon subdivisions,2X7HT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	IQ	Pfam:HxxPF_rpt	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
k59_1635937_1	32057.KB217478_gene3340	4.87e-06	55.5	COG0515@1|root,COG4191@1|root,COG0515@2|Bacteria,COG4191@2|Bacteria,1G07W@1117|Cyanobacteria,1HQWI@1161|Nostocales	1117|Cyanobacteria	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9
k59_470809_1	324602.Caur_3302	2.18e-45	158.0	COG2141@1|root,COG2141@2|Bacteria,2G87P@200795|Chloroflexi,377SH@32061|Chloroflexia	32061|Chloroflexia	C	Luciferase-like monooxygenase	-	-	1.14.14.5	ko:K04091	ko00920,map00920	-	R07210,R10206	RC01779,RC02556	ko00000,ko00001,ko01000	-	-	-	Bac_luciferase
k59_1359335_1	1121441.AUCX01000017_gene2043	2.65e-30	121.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,42N5S@68525|delta/epsilon subdivisions,2WIUS@28221|Deltaproteobacteria,2M92Z@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	SMART Adenylyl cyclase class-3 4 guanylyl cyclase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
k59_915821_1	1121918.ARWE01000001_gene3470	5.21e-08	58.2	COG1234@1|root,COG1234@2|Bacteria,1PE64@1224|Proteobacteria,42RZR@68525|delta/epsilon subdivisions,2WMCC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
k59_1525864_1	215803.DB30_5827	5.53e-49	166.0	COG3324@1|root,COG3324@2|Bacteria,1R81W@1224|Proteobacteria,430ZU@68525|delta/epsilon subdivisions,2WWJB@28221|Deltaproteobacteria,2YV8T@29|Myxococcales	28221|Deltaproteobacteria	S	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
k59_857566_1	997346.HMPREF9374_0476	1.47e-140	408.0	COG0133@1|root,COG0133@2|Bacteria,1TPI3@1239|Firmicutes,4H9WC@91061|Bacilli,27AVB@186824|Thermoactinomycetaceae	91061|Bacilli	E	Pyridoxal-phosphate dependent enzyme	trpB	GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.20,5.3.1.24	ko:K01696,ko:K01817	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722,R03509	RC00209,RC00210,RC00700,RC00701,RC00945,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU22640	PALP
k59_246925_1	330214.NIDE0545	6e-22	97.1	COG0745@1|root,COG2202@1|root,COG3290@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG3290@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GGDEF,HATPase_c,PAS,PAS_3,PAS_4,PAS_9,Response_reg,SpoIIE,dCache_1
k59_747720_1	867845.KI911784_gene1475	4.43e-32	124.0	COG0624@1|root,COG0624@2|Bacteria,2G63E@200795|Chloroflexi	200795|Chloroflexi	E	peptidase dimerisation domain protein	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
k59_747720_2	1462527.CCDM010000005_gene5158	1.18e-05	48.9	COG0524@1|root,COG0524@2|Bacteria,1TQRC@1239|Firmicutes,4HA87@91061|Bacilli,23KEE@182709|Oceanobacillus	91061|Bacilli	G	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway	rbsK	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
k59_80317_1	926569.ANT_14470	1.64e-105	332.0	COG1529@1|root,COG2080@1|root,COG1529@2|Bacteria,COG2080@2|Bacteria,2G5NF@200795|Chloroflexi	200795|Chloroflexi	C	COGs COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs	xdh	-	-	ko:K12528	ko00450,map00450	-	R07229	RC02420	ko00000,ko00001	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2
k59_1081070_1	797209.ZOD2009_09785	1.17e-14	75.9	COG1266@1|root,arCOG02768@2157|Archaea,2XZ3X@28890|Euryarchaeota,23WZT@183963|Halobacteria	183963|Halobacteria	S	metal-dependent membrane protease	-	-	-	-	-	-	-	-	-	-	-	-	Abi
k59_1470778_1	1408419.JHYG01000012_gene2002	2.44e-23	97.4	COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,2U0EE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
k59_970617_1	269799.Gmet_2119	5.44e-24	97.4	COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,42MD6@68525|delta/epsilon subdivisions,2WMNX@28221|Deltaproteobacteria,43UCX@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Cytochrome b(N-terminal)/b6/petB	pcmC	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_B
k59_1137502_1	322710.Avin_51170	0.000534	47.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,1RNK8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	COG2931 RTX toxins and related Ca2 -binding proteins	psmE	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Cadherin_3,DUF4114,He_PIG,HemolysinCabind,Pectate_lyase_3,Peptidase_M10,Peptidase_M10_C
k59_1693353_1	497964.CfE428DRAFT_1861	3.26e-15	80.1	COG1595@1|root,COG4194@1|root,COG1595@2|Bacteria,COG4194@2|Bacteria,46TQ4@74201|Verrucomicrobia	74201|Verrucomicrobia	K	RNA polymerase sigma factor, sigma-70 family	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2,TonB_C
k59_970630_1	264198.Reut_B4980	5.91e-20	92.4	COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,2VHSI@28216|Betaproteobacteria,1K38N@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Phospholipase D Transphosphatidylase	-	-	-	ko:K06132	ko00564,ko01100,map00564,map01100	-	R11062	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
k59_525314_1	1121396.KB893076_gene721	9.09e-10	58.9	COG0010@1|root,COG0010@2|Bacteria,1MVFH@1224|Proteobacteria,42MXZ@68525|delta/epsilon subdivisions,2WJWG@28221|Deltaproteobacteria,2MIZR@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Arginase family	-	-	3.5.3.1	ko:K01476	ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146	M00029,M00134	R00551	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
k59_525314_2	871968.DESME_06325	5.48e-17	80.5	COG0622@1|root,COG0622@2|Bacteria,1V7VB@1239|Firmicutes,2593B@186801|Clostridia,2628M@186807|Peptococcaceae	186801|Clostridia	S	TIGRFAM phosphoesterase, MJ0936 family	-	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	Metallophos_2
k59_1525901_1	1254432.SCE1572_34585	1.73e-43	157.0	COG3547@1|root,COG3547@2|Bacteria	2|Bacteria	L	Transposase (IS116 IS110 IS902 family)	tnp3510a	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1713815_1	1522072.IL54_2155	3.24e-50	170.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,2TR9H@28211|Alphaproteobacteria,2K3M8@204457|Sphingomonadales	204457|Sphingomonadales	C	Cysteine-rich domain	-	-	-	ko:K11473,ko:K18928	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_7
k59_1324766_1	1382356.JQMP01000003_gene2155	1.72e-38	142.0	COG0006@1|root,COG0006@2|Bacteria,2G5J8@200795|Chloroflexi,27Z3N@189775|Thermomicrobia	189775|Thermomicrobia	E	Metallopeptidase family M24	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M24
k59_1654719_1	582744.Msip34_2812	2.92e-84	267.0	COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,2VHVY@28216|Betaproteobacteria,2KKU5@206350|Nitrosomonadales	206350|Nitrosomonadales	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
k59_653714_1	1121405.dsmv_2319	3.88e-13	73.6	COG0388@1|root,COG0454@1|root,COG0388@2|Bacteria,COG0456@2|Bacteria,1MX4I@1224|Proteobacteria,42N4T@68525|delta/epsilon subdivisions,2WJK8@28221|Deltaproteobacteria,2MIQ0@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,CN_hydrolase
k59_936938_1	1122138.AQUZ01000055_gene6239	4e-54	185.0	COG2141@1|root,COG4639@1|root,COG2141@2|Bacteria,COG4639@2|Bacteria,2GM7W@201174|Actinobacteria,4DPZ7@85009|Propionibacteriales	201174|Actinobacteria	C	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_33,Bac_luciferase
k59_491302_1	643648.Slip_0945	2.34e-37	137.0	COG1206@1|root,COG1206@2|Bacteria,1TP67@1239|Firmicutes,24971@186801|Clostridia,42JH5@68298|Syntrophomonadaceae	186801|Clostridia	J	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs	trmFO	-	2.1.1.74	ko:K04094	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	GIDA
k59_491302_2	1229204.AMYY01000033_gene2338	3.71e-10	60.8	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,2TRGN@28211|Alphaproteobacteria,4BPJJ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom
k59_433193_1	34506.g3058	2.11e-10	67.0	COG0265@1|root,KOG1320@2759|Eukaryota,38G0B@33154|Opisthokonta,3BA39@33208|Metazoa,3CU4J@33213|Bilateria,40GYK@6231|Nematoda	33208|Metazoa	O	Trypsin-like peptidase domain	-	-	3.4.21.107,3.4.21.108	ko:K04771,ko:K08669	ko01503,ko02020,ko04210,ko04214,ko04215,ko05012,map01503,map02020,map04210,map04214,map04215,map05012	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Ribosomal_L24e,Trypsin_2
k59_43330_1	309807.SRU_1928	7.74e-58	198.0	COG5276@1|root,COG5276@2|Bacteria,4NDUD@976|Bacteroidetes,1FIMC@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,LVIVD,MAM,TSP_3,fn3
k59_208942_1	414684.RC1_3619	8.4e-79	249.0	COG0312@1|root,COG0312@2|Bacteria,1MUVW@1224|Proteobacteria,2TSAV@28211|Alphaproteobacteria,2JQGM@204441|Rhodospirillales	204441|Rhodospirillales	S	Zn-dependent proteases and their inactivated homologs	pmbA	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
k59_1324794_1	880073.Calab_0511	1.19e-44	155.0	COG4221@1|root,COG4221@2|Bacteria,2NPJV@2323|unclassified Bacteria	2|Bacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short
k59_1157424_1	1379270.AUXF01000001_gene2161	3.09e-67	229.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,COG1146@2|Bacteria	2|Bacteria	C	4 iron, 4 sulfur cluster binding	nifJ	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4,Fer4_16,Fer4_6,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_1543892_1	1123489.AUAN01000005_gene1633	1.71e-40	146.0	COG0772@1|root,COG0772@2|Bacteria,1TPGH@1239|Firmicutes,4H21I@909932|Negativicutes	909932|Negativicutes	M	Peptidoglycan polymerase that is essential for cell wall elongation	rodA	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
k59_653757_1	656024.FsymDg_2386	2.84e-05	51.2	COG0705@1|root,COG0705@2|Bacteria,2GNPK@201174|Actinobacteria,4ESF4@85013|Frankiales	201174|Actinobacteria	S	PFAM Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
k59_1270144_1	501479.ACNW01000035_gene2187	8.15e-60	205.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2U2QW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_877815_1	1541065.JRFE01000014_gene1584	5.84e-13	74.3	COG1529@1|root,COG1529@2|Bacteria,1GBFS@1117|Cyanobacteria,3VM3G@52604|Pleurocapsales	1117|Cyanobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_1211657_1	1333998.M2A_1924	1.7e-24	106.0	COG4246@1|root,COG4246@2|Bacteria,1N7Y1@1224|Proteobacteria,2TTZW@28211|Alphaproteobacteria,4BSGP@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Esterase-like activity of phytase	-	-	-	-	-	-	-	-	-	-	-	-	Phytase-like
k59_1270153_1	1519464.HY22_02295	3.73e-48	170.0	COG2204@1|root,COG2204@2|Bacteria,1FES6@1090|Chlorobi	1090|Chlorobi	T	Two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_822595_1	138119.DSY3851	2.07e-27	118.0	COG1129@1|root,COG4720@1|root,COG1129@2|Bacteria,COG4720@2|Bacteria,1TQRP@1239|Firmicutes,24YCF@186801|Clostridia,267B9@186807|Peptococcaceae	186801|Clostridia	G	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K16785,ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran,ECF-ribofla_trS,ECF_trnsprt
k59_1654797_1	1293047.CBMA010000052_gene3259	4.04e-08	55.1	COG1131@1|root,arCOG00194@2157|Archaea,2XTJV@28890|Euryarchaeota,23T3F@183963|Halobacteria	183963|Halobacteria	E	ABC-type multidrug transport system, ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1654797_2	991905.SL003B_1112	6.16e-48	160.0	COG0600@1|root,COG0600@2|Bacteria,1MWS0@1224|Proteobacteria,2VET7@28211|Alphaproteobacteria,4BTCX@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K15554	ko00920,ko02010,map00920,map02010	M00436	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.17.2	-	-	BPD_transp_1
k59_1379533_1	861299.J421_3561	8.39e-75	244.0	COG0556@1|root,COG0556@2|Bacteria,1ZSQS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
k59_265161_1	714943.Mucpa_0354	8.23e-12	70.9	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_544513_1	649638.Trad_1259	3.17e-76	239.0	COG0045@1|root,COG0045@2|Bacteria,1WIT1@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
k59_544513_2	1121097.JCM15093_346	1.56e-06	48.9	COG0074@1|root,COG0074@2|Bacteria,4NE6B@976|Bacteroidetes,2FM2M@200643|Bacteroidia,4AN34@815|Bacteroidaceae	976|Bacteroidetes	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA,Succ_CoA_lig
k59_1654814_1	215803.DB30_1796	2.81e-106	332.0	COG1960@1|root,COG1960@2|Bacteria,1RIW2@1224|Proteobacteria,439BZ@68525|delta/epsilon subdivisions,2X4K0@28221|Deltaproteobacteria,2YZ65@29|Myxococcales	28221|Deltaproteobacteria	I	Acyl-CoA oxidase	-	-	1.3.3.6	ko:K00232	ko00071,ko00592,ko01040,ko01100,ko01110,ko01212,ko03320,ko04024,ko04146,map00071,map00592,map01040,map01100,map01110,map01212,map03320,map04024,map04146	M00087,M00113	R01175,R01279,R03777,R03857,R03990,R04751,R04754,R07888,R07892,R07896,R07934,R07950	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000	-	-	-	ACOX,Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_265169_1	1173264.KI913949_gene2216	4.18e-12	70.5	COG2027@1|root,COG2027@2|Bacteria,1G0QN@1117|Cyanobacteria,1H91Q@1150|Oscillatoriales	1117|Cyanobacteria	M	D-Ala-D-Ala carboxypeptidase 3 (S13) family	-	-	3.4.16.4	ko:K07259	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S13
k59_1047295_1	338963.Pcar_1442	1.6e-47	166.0	COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,42M0T@68525|delta/epsilon subdivisions,2WJ3C@28221|Deltaproteobacteria,43SDW@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Serine hydroxymethyltransferase	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
k59_1324866_1	1123368.AUIS01000001_gene1896	5.92e-63	213.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,1SJQ1@1236|Gammaproteobacteria,2NDRU@225057|Acidithiobacillales	225057|Acidithiobacillales	G	Transketolase, thiamine diphosphate binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
k59_1047298_2	1547437.LL06_18160	4.59e-07	54.7	COG1018@1|root,COG1018@2|Bacteria,1MY2Q@1224|Proteobacteria,2U0WY@28211|Alphaproteobacteria,43J7K@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	Oxidoreductase FAD-binding domain	paaE	-	-	ko:K02613	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
k59_378101_1	1207063.P24_00990	1.03e-38	140.0	COG0683@1|root,COG0683@2|Bacteria,1NHBN@1224|Proteobacteria,2TWTC@28211|Alphaproteobacteria,2JYPG@204441|Rhodospirillales	28211|Alphaproteobacteria	E	COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_766304_1	450851.PHZ_c3183	8.79e-24	93.6	COG1950@1|root,COG1950@2|Bacteria,1N1DF@1224|Proteobacteria,2UDEK@28211|Alphaproteobacteria,2KGZA@204458|Caulobacterales	204458|Caulobacterales	S	PFAM Membrane protein of	-	-	-	ko:K08972	-	-	-	-	ko00000	-	-	-	Phage_holin_4_2
k59_766304_2	84531.JMTZ01000002_gene779	1.94e-43	145.0	COG3791@1|root,COG3791@2|Bacteria,1N6S5@1224|Proteobacteria,1SCC4@1236|Gammaproteobacteria,1X8DT@135614|Xanthomonadales	135614|Xanthomonadales	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
k59_209034_1	886379.AEWI01000149_gene3383	1.18e-54	186.0	COG0366@1|root,COG0366@2|Bacteria,4NEVK@976|Bacteroidetes,2FNVI@200643|Bacteroidia,3XJM5@558415|Marinilabiliaceae	976|Bacteroidetes	G	Maltogenic Amylase, C-terminal domain	amyB	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,Alpha-amylase_C,DUF3459,Malt_amylase_C
k59_433310_1	296591.Bpro_5256	2.07e-74	241.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VNQD@28216|Betaproteobacteria,4AAKZ@80864|Comamonadaceae	28216|Betaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	aliA	-	-	ko:K04116	ko00362,ko01120,map00362,map01120	M00540	R05620	RC00004,RC01438	ko00000,ko00001,ko00002,ko01000	-	-	-	AMP-binding,AMP-binding_C
k59_766316_1	1231392.OCGS_0121	3.47e-102	303.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2U0FG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
k59_491458_1	1379270.AUXF01000003_gene3427	1.03e-57	189.0	COG0356@1|root,COG0356@2|Bacteria,1ZSQ5@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
k59_1491062_1	981369.JQMJ01000004_gene5420	1.82e-28	112.0	COG0276@1|root,COG0276@2|Bacteria,2GJTQ@201174|Actinobacteria,2NG8G@228398|Streptacidiphilus	201174|Actinobacteria	H	Ferrochelatase	hemH	GO:0003674,GO:0003824,GO:0004325,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0040007,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0046148,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051537,GO:0051540,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
k59_1491062_2	926550.CLDAP_19070	7.28e-44	150.0	COG3253@1|root,COG3253@2|Bacteria	2|Bacteria	S	peroxidase activity	ywfI	-	-	ko:K00435	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R11522	RC00884	ko00000,ko00001,ko01000	-	-	-	Chlor_dismutase
k59_1654899_1	926569.ANT_06880	5.44e-47	167.0	COG0642@1|root,COG2203@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria	2|Bacteria	T	PhoQ Sensor	devS	GO:0000166,GO:0000287,GO:0001666,GO:0003032,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005488,GO:0005509,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0009593,GO:0009628,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0017076,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0019825,GO:0019826,GO:0020037,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0036293,GO:0040007,GO:0042165,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046777,GO:0046872,GO:0046906,GO:0048037,GO:0050896,GO:0051606,GO:0051775,GO:0051776,GO:0070025,GO:0070026,GO:0070482,GO:0070483,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564	2.7.13.3	ko:K07682	ko02020,map02020	M00482	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	GAF,GAF_2,GAF_3,HATPase_c,HATPase_c_2,HisKA_3
k59_155174_1	765910.MARPU_09755	2.21e-46	169.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WXV4@135613|Chromatiales	135613|Chromatiales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_433348_1	926550.CLDAP_24920	1.74e-74	235.0	COG0451@1|root,COG0451@2|Bacteria,2G8B1@200795|Chloroflexi	200795|Chloroflexi	GM	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
k59_378164_1	997884.HMPREF1068_00528	1.55e-57	201.0	COG0532@1|root,COG0532@2|Bacteria,4NGP3@976|Bacteroidetes,2FM01@200643|Bacteroidia,4AKHK@815|Bacteroidaceae	976|Bacteroidetes	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N
k59_937100_1	1244869.H261_18682	1.57e-18	81.3	COG0718@1|root,COG0718@2|Bacteria,1RGZD@1224|Proteobacteria,2UBQB@28211|Alphaproteobacteria,2JT9R@204441|Rhodospirillales	204441|Rhodospirillales	S	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection	-	-	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
k59_937100_2	1321815.HMPREF9193_01892	4.69e-22	92.0	COG0353@1|root,COG0353@2|Bacteria,2J74I@203691|Spirochaetes	203691|Spirochaetes	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecR,Toprim_4
k59_491526_1	1499967.BAYZ01000108_gene2198	6.41e-18	87.8	COG1609@1|root,COG1609@2|Bacteria	2|Bacteria	K	purine nucleotide biosynthetic process	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
k59_43511_1	671143.DAMO_0178	3.44e-113	337.0	COG3405@1|root,COG3405@2|Bacteria,2NRVX@2323|unclassified Bacteria	2|Bacteria	G	Glycosyl hydrolases family 8	bcsZ	GO:0003674,GO:0003824,GO:0004553,GO:0005575,GO:0005576,GO:0008810,GO:0016787,GO:0016798	3.2.1.4	ko:K01179,ko:K20542	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH8,GH9	-	Glyco_hydro_8
k59_378189_1	1242864.D187_009651	2.82e-13	68.9	COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,42M0J@68525|delta/epsilon subdivisions,2WK1D@28221|Deltaproteobacteria,2YWE7@29|Myxococcales	28221|Deltaproteobacteria	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N,Glyco_hydro_2
k59_1766395_1	358823.DF19_14115	1.87e-18	90.1	28KB1@1|root,2Z9Y5@2|Bacteria,2GM37@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_653915_1	319224.Sputcn32_2341	1.14e-08	61.2	COG1629@1|root,COG4771@2|Bacteria,1MXY7@1224|Proteobacteria,1T3Y6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Outer membrane protein beta-barrel family	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug
k59_1379671_2	1132855.KB913035_gene1772	8.86e-32	124.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2VIE4@28216|Betaproteobacteria	28216|Betaproteobacteria	L	PFAM transposase, IS4 family protein	-	-	-	ko:K07487	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_265277_1	871968.DESME_15740	2.43e-108	327.0	COG0104@1|root,COG0104@2|Bacteria,1TQ4C@1239|Firmicutes,247RN@186801|Clostridia,260YE@186807|Peptococcaceae	186801|Clostridia	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
k59_155227_1	886293.Sinac_1091	1.8e-62	193.0	COG1917@1|root,COG1917@2|Bacteria,2J385@203682|Planctomycetes	203682|Planctomycetes	S	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_155227_2	1185876.BN8_06444	3.14e-19	87.4	COG2272@1|root,COG2272@2|Bacteria,4NF5N@976|Bacteroidetes,47MY3@768503|Cytophagia	976|Bacteroidetes	I	Belongs to the type-B carboxylesterase lipase family	-	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase
k59_1047396_1	357808.RoseRS_0453	1.03e-58	189.0	COG0640@1|root,COG3860@1|root,COG0640@2|Bacteria,COG3860@2|Bacteria,2G8TH@200795|Chloroflexi,377X2@32061|Chloroflexia	32061|Chloroflexia	K	Uncharacterized protein conserved in bacteria (DUF2087)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2087,HTH_5
k59_1601616_1	1121123.AUAO01000002_gene195	5.65e-22	99.4	COG2234@1|root,COG2234@2|Bacteria,1MV86@1224|Proteobacteria,2TVJ5@28211|Alphaproteobacteria,2KFR6@204458|Caulobacterales	204458|Caulobacterales	S	PA domain	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
k59_209113_1	1123054.KB907712_gene431	4.93e-10	60.1	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria,1WWG5@135613|Chromatiales	135613|Chromatiales	V	pfam abc	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
k59_209113_2	404589.Anae109_4314	0.000701	45.4	COG1452@1|root,COG1452@2|Bacteria	2|Bacteria	M	lipopolysaccharide transport	-	-	-	ko:K09774	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	LptC
k59_209127_1	314287.GB2207_11138	3.82e-30	120.0	COG0628@1|root,COG0628@2|Bacteria,1MXXU@1224|Proteobacteria,1RQCM@1236|Gammaproteobacteria,1J4EG@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	AI-2E family transporter	tqsA	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0009372,GO:0009987,GO:0015562,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0044764,GO:0051179,GO:0051234,GO:0051704,GO:0055085,GO:0071944	-	ko:K11744	-	-	-	-	ko00000	-	-	-	AI-2E_transport
k59_1655001_1	861299.J421_2513	1.03e-15	76.3	COG4867@1|root,COG4867@2|Bacteria,1ZT0B@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2
k59_1655001_2	526227.Mesil_0270	4.52e-24	100.0	COG1194@1|root,COG1194@2|Bacteria,1WI9U@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	L	PFAM HhH-GPD superfamily base excision DNA repair protein	mutY	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD,NUDIX_4
k59_1047428_1	288000.BBta_0440	3.11e-35	122.0	COG2963@1|root,COG2963@2|Bacteria,1RGZ5@1224|Proteobacteria,2UAIS@28211|Alphaproteobacteria,3K1PX@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Transposase	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_43561_1	234267.Acid_7947	5.43e-23	102.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_713369_1	177437.HRM2_15130	2.41e-25	109.0	COG5557@1|root,COG5557@2|Bacteria,1QURB@1224|Proteobacteria,43BT1@68525|delta/epsilon subdivisions,2X73S@28221|Deltaproteobacteria,2MMX3@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Pfam Polysulphide reductase, NrfD	actF	-	-	-	-	-	-	-	-	-	-	-	-
k59_653969_1	467661.RKLH11_222	4.01e-26	107.0	COG4122@1|root,COG4122@2|Bacteria,1R9D7@1224|Proteobacteria,2U823@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_24
k59_1325056_1	1121382.JQKG01000026_gene2919	2.66e-98	296.0	COG3508@1|root,COG3508@2|Bacteria	2|Bacteria	Q	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate	hmgA	-	1.13.11.5	ko:K00451	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R02519	RC00737	ko00000,ko00001,ko00002,ko01000	-	-	-	HgmA
k59_1434406_1	661478.OP10G_1029	1.47e-30	120.0	COG3844@1|root,COG3844@2|Bacteria	2|Bacteria	E	kynureninase activity	kynU	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016054,GO:0016787,GO:0016822,GO:0016823,GO:0019439,GO:0019441,GO:0019752,GO:0030429,GO:0032787,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043420,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0070189,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	3.7.1.3	ko:K01556	ko00380,ko01100,map00380,map01100	M00038	R00987,R02668,R03936	RC00284,RC00415	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5
k59_713416_1	331869.BAL199_09835	2.6e-75	249.0	COG0668@1|root,COG0668@2|Bacteria,1MY0I@1224|Proteobacteria,2TSIN@28211|Alphaproteobacteria,4BQ8D@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	M	Mechanosensitive ion channel	-	-	-	ko:K22044	-	-	-	-	ko00000,ko02000	1.A.23.3	-	-	MS_channel
k59_209202_1	592031.GCWU000322_00520	3.21e-51	176.0	COG0541@1|root,COG0541@2|Bacteria,1TP06@1239|Firmicutes,248EU@186801|Clostridia,25V24@186806|Eubacteriaceae	186801|Clostridia	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
k59_1601712_1	1191523.MROS_0276	3.75e-07	53.5	COG0356@1|root,COG0356@2|Bacteria	2|Bacteria	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
k59_1714101_1	1444309.JAQG01000021_gene1373	1.9e-22	100.0	COG1228@1|root,COG1228@2|Bacteria,1TQQ0@1239|Firmicutes,4HDKW@91061|Bacilli,26QUJ@186822|Paenibacillaceae	91061|Bacilli	Q	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_435407_2	411684.HPDFL43_11786	2.3e-65	210.0	COG2128@1|root,COG2128@2|Bacteria,1N82C@1224|Proteobacteria,2TSPV@28211|Alphaproteobacteria,43NY3@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3179)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3179
k59_1768829_1	525904.Tter_0409	3.75e-85	270.0	COG0277@1|root,COG0277@2|Bacteria,2NP1E@2323|unclassified Bacteria	2|Bacteria	C	FAD linked oxidases, C-terminal domain	glcD	-	1.1.3.15	ko:K00104,ko:K18930	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_546732_2	379066.GAU_1714	7.69e-58	189.0	COG1702@1|root,COG1702@2|Bacteria,1ZSSD@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	PhoH-like protein	-	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
k59_285196_1	1122951.ATUE01000010_gene311	1.64e-05	52.8	COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,1RPC6@1236|Gammaproteobacteria,3NIUR@468|Moraxellaceae	1236|Gammaproteobacteria	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA	recB	GO:0000166,GO:0000724,GO:0000725,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0004518,GO:0004519,GO:0004520,GO:0004527,GO:0004529,GO:0004536,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006952,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0008854,GO:0009314,GO:0009338,GO:0009628,GO:0009987,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016788,GO:0016796,GO:0016817,GO:0016818,GO:0016887,GO:0016895,GO:0017076,GO:0017111,GO:0030554,GO:0032392,GO:0032508,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044355,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0099046,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1902494	3.1.11.5	ko:K03582	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
k59_840811_2	1396418.BATQ01000106_gene5355	1.47e-11	67.0	COG3794@1|root,COG3794@2|Bacteria,46SUG@74201|Verrucomicrobia,2IVQT@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1619134_1	574087.Acear_1890	4.91e-13	73.6	COG5662@1|root,COG5662@2|Bacteria,1UHWV@1239|Firmicutes,24JF8@186801|Clostridia,3WBR9@53433|Halanaerobiales	186801|Clostridia	K	Domain of unknown function (DUF4349)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4349,zf-HC2
k59_507503_1	479434.Sthe_1008	5.18e-19	89.7	COG0454@1|root,COG0456@2|Bacteria,2G6N6@200795|Chloroflexi	200795|Chloroflexi	K	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_1508204_1	880073.Calab_3175	2.65e-97	293.0	COG1064@1|root,COG1064@2|Bacteria,2NP06@2323|unclassified Bacteria	2|Bacteria	S	Alcohol dehydrogenase GroES-like domain	adhA	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_840819_1	1238186.AOCN01000016_gene253	5.34e-24	101.0	COG0628@1|root,COG0628@2|Bacteria,2GK0H@201174|Actinobacteria,4FKUH@85023|Microbacteriaceae	201174|Actinobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
k59_229650_1	1211815.CBYP010000074_gene3608	2.01e-53	185.0	COG1012@1|root,COG1012@2|Bacteria,2GJ95@201174|Actinobacteria,4EU3Z@85013|Frankiales	201174|Actinobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.99.10	ko:K22445	-	-	-	-	ko00000,ko01000	-	-	-	Aldedh
k59_1452862_1	999550.KI421507_gene1547	9.58e-45	151.0	COG0315@1|root,COG0315@2|Bacteria,1RCYZ@1224|Proteobacteria,2U747@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
k59_952314_1	1502724.FF80_01545	2.81e-20	84.3	COG2154@1|root,COG2154@2|Bacteria,1MZ5Q@1224|Proteobacteria,2UBWN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	pterin-4-alpha-carbinolamine dehydratase	phhB	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
k59_952314_2	1448389.BAVQ01000003_gene3421	6e-76	234.0	COG0842@1|root,COG0842@2|Bacteria,2GKJF@201174|Actinobacteria	201174|Actinobacteria	V	transport, permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
k59_1341391_1	188626.HMPREF0321_1906	2.38e-28	110.0	COG0036@1|root,COG0036@2|Bacteria,2GJZ9@201174|Actinobacteria,1ZVGI@145357|Dermacoccaceae	201174|Actinobacteria	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
k59_1007993_1	706587.Desti_1505	1.52e-62	209.0	COG0477@1|root,COG2814@2|Bacteria,1MUZ8@1224|Proteobacteria,42YIF@68525|delta/epsilon subdivisions,2WU4S@28221|Deltaproteobacteria,2MQET@213462|Syntrophobacterales	28221|Deltaproteobacteria	EGP	PFAM Major Facilitator Superfamily	-	-	-	ko:K08218	ko01501,map01501	M00628	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.25	-	-	MFS_1
k59_896866_1	926569.ANT_16390	3.12e-35	124.0	2FJCP@1|root,34B2I@2|Bacteria,2G94J@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1396991_1	999423.HMPREF9161_01574	4.84e-13	64.7	COG0093@1|root,COG0093@2|Bacteria,1V3N0@1239|Firmicutes,4H4B6@909932|Negativicutes	909932|Negativicutes	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	-	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
k59_1396991_2	335543.Sfum_1566	8.26e-39	132.0	COG0198@1|root,COG0198@2|Bacteria,1MZQD@1224|Proteobacteria,42TGC@68525|delta/epsilon subdivisions,2WQ2G@28221|Deltaproteobacteria,2MS2M@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplX	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
k59_396268_1	1123376.AUIU01000012_gene1512	3.49e-72	243.0	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,3J0TJ@40117|Nitrospirae	40117|Nitrospirae	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C,GATase_5
k59_730144_1	448385.sce5248	5.64e-29	109.0	COG0662@1|root,COG0662@2|Bacteria,1NB9H@1224|Proteobacteria,43EDY@68525|delta/epsilon subdivisions,2X9DD@28221|Deltaproteobacteria,2Z2J0@29|Myxococcales	28221|Deltaproteobacteria	G	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_730144_2	1382306.JNIM01000001_gene1945	0.000355	44.3	COG2070@1|root,COG2070@2|Bacteria,2G78C@200795|Chloroflexi	200795|Chloroflexi	S	Nitronate monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	NMO
k59_1730487_1	926569.ANT_10900	6.08e-79	244.0	COG2949@1|root,COG2949@2|Bacteria,2G6VI@200795|Chloroflexi	200795|Chloroflexi	S	DUF218 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
k59_618546_1	879212.DespoDRAFT_03654	1.8e-23	98.6	COG0577@1|root,COG0577@2|Bacteria,1MWBK@1224|Proteobacteria,42PZC@68525|delta/epsilon subdivisions,2WK59@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_618546_2	1121448.DGI_2946	3.22e-73	226.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,42QF5@68525|delta/epsilon subdivisions,2WK2K@28221|Deltaproteobacteria,2M96E@213115|Desulfovibrionales	28221|Deltaproteobacteria	V	pfam abc	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1341404_2	1379270.AUXF01000006_gene203	1.67e-13	65.9	28VAR@1|root,2ZHDJ@2|Bacteria,1ZU25@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	rpoZ	-	-	-	-	-	-	-	-	-	-	-	RNA_pol_Rpb6
k59_1341404_3	1124983.PFLCHA0_c60110	1.83e-14	73.2	COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,1RMKQ@1236|Gammaproteobacteria,1YP8G@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	GO:0000166,GO:0003674,GO:0003824,GO:0004632,GO:0004633,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0010181,GO:0015936,GO:0015937,GO:0016829,GO:0016830,GO:0016831,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032553,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	iEC042_1314.EC042_3945,iECUMN_1333.ECUMN_4154,iJN746.PP_5285,iSBO_1134.SBO_3641	DFP,Flavoprotein
k59_1452887_1	1244869.H261_02186	1.03e-65	217.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,2TS07@28211|Alphaproteobacteria,2JPIQ@204441|Rhodospirillales	204441|Rhodospirillales	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
k59_1008018_2	194439.CT0149	3.3e-05	44.7	COG0690@1|root,COG0690@2|Bacteria,1FE96@1090|Chlorobi	1090|Chlorobi	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	-	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
k59_7388_2	1233950.IW22_24410	1.53e-12	67.8	2AKCX@1|root,31B42@2|Bacteria,4P1TT@976|Bacteroidetes,1IHFI@117743|Flavobacteriia,3ZU5G@59732|Chryseobacterium	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1508243_1	1173026.Glo7428_1768	3.27e-74	253.0	COG1020@1|root,COG1020@2|Bacteria	2|Bacteria	Q	D-alanine [D-alanyl carrier protein] ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,Methyltransf_21,PP-binding,Thioesterase
k59_840858_1	868595.Desca_0520	1.66e-86	285.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1TQ0B@1239|Firmicutes,248IB@186801|Clostridia,260N1@186807|Peptococcaceae	186801|Clostridia	E	glutamate synthase	gltB	-	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_1174599_1	84531.JMTZ01000020_gene3702	1.07e-13	70.9	COG1960@1|root,COG1960@2|Bacteria,1MUK0@1224|Proteobacteria,1RNBX@1236|Gammaproteobacteria,1X45S@135614|Xanthomonadales	135614|Xanthomonadales	I	Acyl-CoA dehydrogenase	gcdH	-	1.3.8.6	ko:K00252	ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130	M00032	R02487,R02488,R10074	RC00052,RC00156	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_1063363_1	1150469.RSPPHO_03277	3.46e-19	88.6	COG1216@1|root,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_507559_1	497964.CfE428DRAFT_3727	2.11e-23	97.1	2FH6M@1|root,34912@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4203)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4203
k59_618578_1	1121904.ARBP01000008_gene3377	4.27e-19	91.7	COG1858@1|root,COG1858@2|Bacteria,4NE50@976|Bacteroidetes,47KXQ@768503|Cytophagia	976|Bacteroidetes	C	cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG
k59_562898_1	1000565.METUNv1_00698	6.15e-54	191.0	COG4232@1|root,COG4233@1|root,COG4232@2|Bacteria,COG4233@2|Bacteria,1MU8W@1224|Proteobacteria,2VI8I@28216|Betaproteobacteria	28216|Betaproteobacteria	CO	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps	-	-	1.8.1.8	ko:K04084,ko:K08344	-	-	-	-	ko00000,ko01000,ko02000,ko03110	5.A.1.1,5.A.1.5	-	-	DsbC,DsbD,Thioredoxin_7
k59_1341440_1	1121033.AUCF01000004_gene5039	1.31e-89	275.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,2TS63@28211|Alphaproteobacteria,2JPW2@204441|Rhodospirillales	204441|Rhodospirillales	C	Belongs to the citrate synthase family	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
k59_1452919_1	796942.HMPREF9623_00863	7.48e-22	94.7	COG2071@1|root,COG2071@2|Bacteria,1V1KC@1239|Firmicutes,24JCU@186801|Clostridia	186801|Clostridia	G	peptidase C26	ntpR	-	-	ko:K07010	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_C26
k59_1452919_2	1410632.JHWW01000004_gene1622	2.14e-06	47.8	COG0335@1|root,COG0335@2|Bacteria,1V6FT@1239|Firmicutes,24J83@186801|Clostridia,27N93@186928|unclassified Lachnospiraceae	186801|Clostridia	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	-	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
k59_1508268_1	1123393.KB891316_gene1945	8.3e-92	296.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,1KR9P@119069|Hydrogenophilales	28216|Betaproteobacteria	V	AcrB/AcrD/AcrF family	acrD	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_1231071_1	997346.HMPREF9374_0445	4.89e-34	130.0	COG1160@1|root,COG1160@2|Bacteria,1TPNM@1239|Firmicutes,4HAJ6@91061|Bacilli,27BMY@186824|Thermoactinomycetaceae	91061|Bacilli	S	KH-domain-like of EngA bacterial GTPase enzymes, C-terminal	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
k59_1231071_2	926569.ANT_09460	1.66e-61	204.0	COG4856@1|root,COG4856@2|Bacteria,2G75D@200795|Chloroflexi	200795|Chloroflexi	S	PFAM YbbR family protein	-	-	-	-	-	-	-	-	-	-	-	-	YbbR
k59_229722_1	502025.Hoch_4095	2.41e-124	372.0	COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,42NYT@68525|delta/epsilon subdivisions,2WIM3@28221|Deltaproteobacteria,2Z34A@29|Myxococcales	28221|Deltaproteobacteria	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
k59_730221_1	981085.XP_010087589.1	7.12e-34	134.0	COG0367@1|root,KOG0571@2759|Eukaryota,37JXE@33090|Viridiplantae,3GEJM@35493|Streptophyta,4JHBC@91835|fabids	35493|Streptophyta	E	Asparagine synthetase	-	GO:0003674,GO:0003824,GO:0004066,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005911,GO:0006082,GO:0006520,GO:0006528,GO:0006529,GO:0006807,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009314,GO:0009416,GO:0009506,GO:0009628,GO:0009642,GO:0009646,GO:0009651,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0030054,GO:0032787,GO:0034641,GO:0042538,GO:0042802,GO:0042803,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046983,GO:0050896,GO:0055044,GO:0071704,GO:0072330,GO:0097164,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
k59_340573_1	543632.JOJL01000011_gene6846	2.22e-184	530.0	COG3547@1|root,COG3547@2|Bacteria,2IDDB@201174|Actinobacteria	201174|Actinobacteria	L	Transposase and inactivated derivatives	tnp3512a	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1341476_1	1459636.NTE_03279	3.05e-138	406.0	COG1155@1|root,arCOG00868@2157|Archaea,41SZU@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit	atpA	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
k59_1619244_1	1380394.JADL01000009_gene3234	3.01e-16	77.8	COG0795@1|root,COG0795@2|Bacteria,1MVW3@1224|Proteobacteria,2TR76@28211|Alphaproteobacteria,2JPJ2@204441|Rhodospirillales	204441|Rhodospirillales	S	Predicted permease YjgP/YjgQ family	-	-	-	ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
k59_1619244_2	414684.RC1_1378	1.28e-14	76.3	COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,2TR3B@28211|Alphaproteobacteria,2JPHT@204441|Rhodospirillales	204441|Rhodospirillales	M	Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	lptD	-	-	ko:K04744	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA,OstA_C
k59_618616_2	768704.Desmer_4321	3.65e-160	473.0	COG3666@1|root,COG3666@2|Bacteria,1TQQ9@1239|Firmicutes,24AG9@186801|Clostridia,26246@186807|Peptococcaceae	186801|Clostridia	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_1730596_2	765912.Thimo_2554	2.42e-34	123.0	COG0816@1|root,COG0816@2|Bacteria,1RDHZ@1224|Proteobacteria,1S96Q@1236|Gammaproteobacteria,1WYAH@135613|Chromatiales	135613|Chromatiales	L	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	-	-	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
k59_1730596_3	349124.Hhal_0938	8.29e-27	103.0	COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,1S3YV@1236|Gammaproteobacteria,1WX8T@135613|Chromatiales	135613|Chromatiales	K	Belongs to the UPF0301 (AlgH) family	-	-	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
k59_1397105_1	1174528.JH992898_gene977	1.79e-56	193.0	COG5421@1|root,COG5421@2|Bacteria,1G3YW@1117|Cyanobacteria	1117|Cyanobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_897005_1	882083.SacmaDRAFT_1331	6.6e-58	198.0	COG3960@1|root,COG3960@2|Bacteria,2GJY3@201174|Actinobacteria,4DX9N@85010|Pseudonocardiales	201174|Actinobacteria	S	Belongs to the TPP enzyme family	gcl	-	4.1.1.47	ko:K01608	ko00630,ko01100,map00630,map01100	-	R00013	RC00899	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_1563874_1	1077972.ARGLB_118_01060	3.83e-06	52.0	COG1053@1|root,COG1053@2|Bacteria,2GIXG@201174|Actinobacteria	201174|Actinobacteria	C	PFAM fumarate reductase succinate dehydrogenase flavoprotein domain protein	-	-	1.3.99.4	ko:K05898	ko00984,ko01100,ko01120,map00984,map01100,map01120	-	R09884	RC00991	ko00000,ko00001,ko01000	-	-	-	FAD_binding_2
k59_1231158_1	479433.Caci_0975	9.26e-49	169.0	COG1131@1|root,COG1131@2|Bacteria,2GKWB@201174|Actinobacteria	201174|Actinobacteria	V	abc transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1063465_1	1502851.FG93_01033	5.02e-23	98.2	COG3637@1|root,COG3637@2|Bacteria,1NJWW@1224|Proteobacteria,2UD8G@28211|Alphaproteobacteria,3K68N@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Porin subfamily	-	-	-	ko:K16079	-	-	-	-	ko00000,ko02000	1.B.4.2.1	-	-	OMP_b-brl
k59_1063465_2	1120956.JHZK01000030_gene30	1.29e-08	55.5	29APY@1|root,2ZXPR@2|Bacteria,1R817@1224|Proteobacteria,2TSBC@28211|Alphaproteobacteria,1JP2W@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF1849)	MA20_36210	-	-	-	-	-	-	-	-	-	-	-	DUF1849
k59_340628_1	1246995.AFR_08775	6.14e-53	178.0	COG1277@1|root,COG1277@2|Bacteria,2ID14@201174|Actinobacteria,4DCGZ@85008|Micromonosporales	201174|Actinobacteria	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
k59_62869_1	313624.NSP_8860	1.14e-28	119.0	COG2239@1|root,COG2239@2|Bacteria,1G0CN@1117|Cyanobacteria,1HMQJ@1161|Nostocales	1117|Cyanobacteria	P	Acts as a magnesium transporter	mgtE	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
k59_7531_1	639030.JHVA01000001_gene3351	1.54e-32	126.0	COG0492@1|root,COG0492@2|Bacteria,3Y2NX@57723|Acidobacteria,2JI8S@204432|Acidobacteriia	204432|Acidobacteriia	O	L-lysine 6-monooxygenase (NADPH-requiring)	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_3
k59_396418_1	1122939.ATUD01000006_gene1644	6.32e-43	157.0	COG0380@1|root,COG0380@2|Bacteria,2GMX7@201174|Actinobacteria,4CPJV@84995|Rubrobacteria	84995|Rubrobacteria	G	Glycosyl transferase, family 20	-	-	2.4.1.15,2.4.1.347	ko:K00697	ko00500,ko01100,map00500,map01100	-	R02737	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT20	-	Glyco_transf_20
k59_509084_1	1122134.KB893650_gene945	9.07e-70	221.0	COG1131@1|root,COG1131@2|Bacteria,1R3XF@1224|Proteobacteria,1S0MM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	abc transporter atp-binding protein	nodI	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1454578_1	1304865.JAGF01000001_gene2094	0.000309	49.3	COG0210@1|root,COG2887@1|root,COG0210@2|Bacteria,COG2887@2|Bacteria,2GM2E@201174|Actinobacteria,4F10D@85016|Cellulomonadaceae	201174|Actinobacteria	L	Belongs to the helicase family. UvrD subfamily	uvrD2	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
k59_1342956_2	1236000.L0AR07_9CAUD	3.17e-25	103.0	4QAMU@10239|Viruses,4QV4U@35237|dsDNA viruses  no RNA stage,4QPEV@28883|Caudovirales,4QI0J@10662|Myoviridae	10662|Myoviridae	S	Baseplate J-like protein	-	GO:0005575,GO:0019012,GO:0044423,GO:0098015,GO:0098025	-	-	-	-	-	-	-	-	-	-	-
k59_1176244_1	744872.Spica_0145	6.83e-05	47.4	COG0612@1|root,COG0612@2|Bacteria,2J5S5@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Peptidase M16 inactive domain	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_1065002_1	1499967.BAYZ01000184_gene4568	1.29e-125	376.0	COG1966@1|root,COG1966@2|Bacteria,2NNP2@2323|unclassified Bacteria	2|Bacteria	T	5TM C-terminal transporter carbon starvation CstA	cstA	-	-	ko:K06200	-	-	-	-	ko00000	-	-	-	CstA,CstA_5TM
k59_801499_1	42256.RradSPS_1755	1.19e-38	145.0	COG0007@1|root,COG1587@1|root,COG0007@2|Bacteria,COG1587@2|Bacteria,2GMJZ@201174|Actinobacteria,4CU1Q@84995|Rubrobacteria	84995|Rubrobacteria	H	Belongs to the precorrin methyltransferase family	-	-	2.1.1.107,4.2.1.75	ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165,R03194	RC00003,RC00871,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4,TP_methylase
k59_523406_1	318424.EU78_23335	4.75e-82	251.0	COG0491@1|root,COG0491@2|Bacteria,2GMSA@201174|Actinobacteria,2339Y@1762|Mycobacteriaceae	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	ytnP_1	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_633640_1	5693.XP_821559.1	1.35e-10	66.6	COG0631@1|root,KOG0698@2759|Eukaryota,3XYDG@5653|Kinetoplastida	5653|Kinetoplastida	T	Sigma factor PP2C-like phosphatases	-	-	3.1.3.16	ko:K01090	-	-	-	-	ko00000,ko01000	-	-	-	PP2C
k59_1634132_1	861299.J421_3279	6.79e-78	243.0	COG0045@1|root,COG0045@2|Bacteria,1ZSZ4@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
k59_633642_1	1382306.JNIM01000001_gene3736	0.000768	46.6	COG0631@1|root,COG0631@2|Bacteria,2G8RD@200795|Chloroflexi	2|Bacteria	T	SMART protein phosphatase 2C domain protein	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2,Pkinase
k59_412151_1	330214.NIDE2031	7.18e-71	224.0	COG1980@1|root,COG1980@2|Bacteria	2|Bacteria	G	fructose-bisphosphate aldolase activity	fbp	-	3.1.3.11,4.1.2.13	ko:K01622	ko00010,ko00030,ko00051,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00003	R00762,R01068,R01070,R02568,R04780	RC00017,RC00438,RC00439	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_3
k59_245141_1	384765.SIAM614_00582	7.19e-23	101.0	COG3547@1|root,COG3547@2|Bacteria,1MW0N@1224|Proteobacteria,2TUGE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	PFAM transposase IS116 IS110 IS902 family	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_633672_1	195250.CM001776_gene1952	7.94e-79	246.0	COG2223@1|root,COG2223@2|Bacteria	2|Bacteria	P	nitrite transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1524102_2	935261.JAGL01000012_gene3465	2.4e-47	161.0	COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,2TSDZ@28211|Alphaproteobacteria,43GQC@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	H	Belongs to the FPP GGPP synthase family	ispB	GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009108,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0042180,GO:0042181,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110	-	R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
k59_1691005_1	1168067.JAGP01000001_gene182	1.47e-06	53.9	COG2836@1|root,COG2836@2|Bacteria,1RIGJ@1224|Proteobacteria,1S5V1@1236|Gammaproteobacteria,460UR@72273|Thiotrichales	72273|Thiotrichales	S	Cytochrome C biogenesis protein transmembrane region	-	-	-	ko:K09792	-	-	-	-	ko00000	-	-	-	DsbD_2
k59_1079192_1	1177928.TH2_19093	1.64e-76	244.0	COG2719@1|root,COG2719@2|Bacteria,1MW6U@1224|Proteobacteria,2TRJG@28211|Alphaproteobacteria,2JR42@204441|Rhodospirillales	204441|Rhodospirillales	S	SpoVR like protein	-	-	-	ko:K06415	-	-	-	-	ko00000	-	-	-	SpoVR
k59_1412919_1	570967.JMLV01000001_gene2422	1.23e-91	288.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2TS19@28211|Alphaproteobacteria,2JQ9Y@204441|Rhodospirillales	204441|Rhodospirillales	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	nrdA	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC,Ribonuc_red_lgN
k59_690715_1	999547.KI421503_gene73	9.33e-108	318.0	COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,1PBHA@1224|Proteobacteria,2TRQF@28211|Alphaproteobacteria,281ZM@191028|Leisingera	28211|Alphaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,rve,rve_3
k59_1579696_1	1121382.JQKG01000018_gene1086	7.53e-41	147.0	COG0002@1|root,COG0002@2|Bacteria,1WIZ3@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Catalyzes the NADPH-dependent reduction of LysW - aminoadipate 6-phosphate to yield LysW -aminoadipate 6- semialdehyde	lysY	-	-	ko:K05829	ko00220,ko00300,ko01100,ko01110,ko01210,ko01230,map00220,map00300,map01100,map01110,map01210,map01230	M00031,M00763	R09777,R10931	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
k59_801552_1	631454.N177_0159	1.47e-71	233.0	COG0028@1|root,COG0028@2|Bacteria,1R743@1224|Proteobacteria,2U4KA@28211|Alphaproteobacteria,1JPSX@119043|Rhodobiaceae	28211|Alphaproteobacteria	EH	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain	-	-	3.7.1.22	ko:K03336	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R08603	RC02331	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_1247892_1	536019.Mesop_2142	1.01e-184	526.0	COG3845@1|root,COG3845@2|Bacteria,1NT0H@1224|Proteobacteria,2UPJ8@28211|Alphaproteobacteria,43NY1@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	ATPases associated with a variety of cellular activities	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
k59_245169_1	1267534.KB906755_gene4130	2.26e-43	150.0	COG0250@1|root,COG0250@2|Bacteria	2|Bacteria	K	Participates in transcription elongation, termination and antitermination	nusG	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K02601,ko:K05785	-	-	-	-	ko00000,ko03000,ko03009,ko03021	-	-	-	KOW,NusG
k59_690724_1	1097668.BYI23_C002780	2.95e-55	185.0	COG2159@1|root,COG2159@2|Bacteria,1MXI7@1224|Proteobacteria,2VTG7@28216|Betaproteobacteria,1KGWJ@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Amidohydrolase	-	-	4.1.1.52	ko:K22213	-	-	-	-	ko00000,ko01000	-	-	-	Amidohydro_2
k59_968558_2	1123355.JHYO01000011_gene1420	7.56e-24	99.0	COG3773@1|root,COG3773@2|Bacteria,1MWX3@1224|Proteobacteria,2TT15@28211|Alphaproteobacteria,36YF2@31993|Methylocystaceae	28211|Alphaproteobacteria	M	Cell Wall Hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_2
k59_1524130_2	479435.Kfla_4189	5.33e-23	95.9	COG1595@1|root,COG1595@2|Bacteria,2GJUI@201174|Actinobacteria,4DR64@85009|Propionibacteriales	201174|Actinobacteria	K	Sigma-70 region 2	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
k59_746016_1	366602.Caul_0584	7.56e-64	214.0	COG2272@1|root,COG2272@2|Bacteria,1MVQZ@1224|Proteobacteria,2TTHT@28211|Alphaproteobacteria,2KHMC@204458|Caulobacterales	204458|Caulobacterales	I	Carboxylesterase family	-	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase
k59_412212_1	203119.Cthe_2696	4.34e-09	62.8	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1TNZE@1239|Firmicutes,2480H@186801|Clostridia,3WG7J@541000|Ruminococcaceae	186801|Clostridia	H	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	ACPS,Carb_kinase,YjeF_N
k59_133681_1	504472.Slin_5681	9.54e-12	64.3	COG1595@1|root,COG1595@2|Bacteria,4NQCH@976|Bacteroidetes,47PTY@768503|Cytophagia	976|Bacteroidetes	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_468748_1	1126627.BAWE01000006_gene6619	2.32e-156	451.0	COG3039@1|root,COG3039@2|Bacteria,1MVTU@1224|Proteobacteria,2TVIR@28211|Alphaproteobacteria,3JT6Q@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	hmm pf01609	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1_6,DUF772
k59_523483_1	438753.AZC_0439	1.69e-47	170.0	COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,2TRJ9@28211|Alphaproteobacteria,3EY0H@335928|Xanthobacteraceae	28211|Alphaproteobacteria	NU	Peptidoglycan-binding domain 1	-	-	-	ko:K21470	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	PG_binding_1,YkuD
k59_1691055_1	555778.Hneap_0383	2.74e-83	266.0	COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,1RMJB@1236|Gammaproteobacteria,1WW7K@135613|Chromatiales	135613|Chromatiales	T	GTP-binding protein TypA	-	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
k59_468764_1	396588.Tgr7_2473	2.22e-55	186.0	COG4301@1|root,COG4301@2|Bacteria,1MUCG@1224|Proteobacteria,1RR44@1236|Gammaproteobacteria,1WVVH@135613|Chromatiales	135613|Chromatiales	S	Methyltransferase	-	-	2.1.1.44	ko:K18911	ko00340,map00340	-	R01169	RC00003,RC02308	ko00000,ko00001,ko01000	-	-	-	Methyltransf_33
k59_468764_2	457398.HMPREF0326_02857	1.05e-12	64.3	COG0640@1|root,COG0640@2|Bacteria,1MZPS@1224|Proteobacteria,4322C@68525|delta/epsilon subdivisions,2WWD8@28221|Deltaproteobacteria,2MCKU@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
k59_1579752_1	37727.XP_002152392.1	9.51e-21	95.5	COG1012@1|root,COG3325@1|root,KOG2451@2759|Eukaryota,KOG2806@2759|Eukaryota,38CKE@33154|Opisthokonta,3NYUA@4751|Fungi,3QS4H@4890|Ascomycota,20EZD@147545|Eurotiomycetes,3S7E8@5042|Eurotiales	4751|Fungi	C	Dehydrogenase	-	-	1.2.1.24	ko:K00139	ko00250,ko00650,ko01100,ko01120,map00250,map00650,map01100,map01120	M00027	R00713	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_468774_1	546268.NEISUBOT_03712	1.16e-83	256.0	COG0207@1|root,COG0207@2|Bacteria,1MUBD@1224|Proteobacteria,2VIIR@28216|Betaproteobacteria,2KPIK@206351|Neisseriales	206351|Neisseriales	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	thyA	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
k59_855894_1	344747.PM8797T_04445	1.6e-50	179.0	COG4990@1|root,COG4990@2|Bacteria,2IY3C@203682|Planctomycetes	203682|Planctomycetes	S	G8	-	-	-	-	-	-	-	-	-	-	-	-	G8
k59_1357566_1	997296.PB1_04480	2.54e-53	177.0	COG0351@1|root,COG0351@2|Bacteria,1TQ4A@1239|Firmicutes,4HAAH@91061|Bacilli,1ZCQT@1386|Bacillus	91061|Bacilli	H	Phosphomethylpyrimidine kinase	thiD	-	2.7.1.49,2.7.4.7	ko:K00941	ko00730,ko01100,map00730,map01100	M00127	R03471,R04509	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Phos_pyr_kin
k59_133724_1	595537.Varpa_3989	1.74e-63	208.0	COG4941@1|root,COG4941@2|Bacteria,1MU3D@1224|Proteobacteria,2VPJ6@28216|Betaproteobacteria,4ABHA@80864|Comamonadaceae	28216|Betaproteobacteria	K	RNA polymerase sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2
k59_1634260_1	1238182.C882_4385	4.92e-61	211.0	COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,2TQJZ@28211|Alphaproteobacteria,2JPMW@204441|Rhodospirillales	204441|Rhodospirillales	L	Belongs to the helicase family. UvrD subfamily	addA	-	3.6.4.12	ko:K16898	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
k59_1634260_2	743836.AYNA01000035_gene674	1.1e-05	47.4	COG2887@1|root,COG3893@1|root,COG2887@2|Bacteria,COG3893@2|Bacteria,1MY2G@1224|Proteobacteria,2TS74@28211|Alphaproteobacteria,36XJ1@31993|Methylocystaceae	28211|Alphaproteobacteria	L	PD-(D/E)XK nuclease superfamily	addB	-	3.6.4.12	ko:K16899	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	PDDEXK_1
k59_1634272_1	1305737.JAFX01000001_gene3570	1.96e-19	87.4	COG1506@1|root,COG1506@2|Bacteria,4NE2Q@976|Bacteroidetes,47N56@768503|Cytophagia	976|Bacteroidetes	E	Dipeptidyl peptidase IV (DPP IV) N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	DPPIV_N,Peptidase_S9
k59_1190725_1	579405.Dd703_3545	3.48e-16	85.9	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1MW7X@1224|Proteobacteria,1RRF4@1236|Gammaproteobacteria,2JBPV@204037|Dickeya	1236|Gammaproteobacteria	L	Transposase	-	-	-	ko:K07494	-	-	-	-	ko00000	-	-	-	DDE_3,HTH_23,HTH_29,HTH_32,HTH_33
k59_23282_1	1121406.JAEX01000019_gene2772	6.03e-19	87.8	COG0341@1|root,COG0342@1|root,COG0341@2|Bacteria,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,42M6V@68525|delta/epsilon subdivisions,2WJCI@28221|Deltaproteobacteria,2M865@213115|Desulfovibrionales	28221|Deltaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
k59_133760_1	158500.BV97_05789	4.33e-49	169.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2TSA7@28211|Alphaproteobacteria,2K3IJ@204457|Sphingomonadales	204457|Sphingomonadales	L	Transposase domain (DUF772)	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
k59_356168_1	401053.AciPR4_2187	2.18e-26	115.0	COG0577@1|root,COG0577@2|Bacteria,3Y7DY@57723|Acidobacteria,2JKJB@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_1301840_2	338963.Pcar_0642	1.29e-46	164.0	COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,42N91@68525|delta/epsilon subdivisions,2WIMM@28221|Deltaproteobacteria,43T9K@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Metallo-beta-lactamase superfamily domain	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_6,RMMBL
k59_690829_1	751994.AGIG01000007_gene1176	3.41e-06	48.5	COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,1RN22@1236|Gammaproteobacteria,1J559@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iJN746.PP_2469	Phe_tRNA-synt_N,tRNA-synt_2d
k59_690829_2	1121033.AUCF01000003_gene3511	1.48e-51	166.0	COG0292@1|root,COG0292@2|Bacteria,1RGU2@1224|Proteobacteria,2U756@28211|Alphaproteobacteria,2JSNZ@204441|Rhodospirillales	204441|Rhodospirillales	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	-	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
k59_412304_2	314278.NB231_15718	1.36e-39	134.0	COG2963@1|root,COG2963@2|Bacteria,1N8Y3@1224|Proteobacteria	1224|Proteobacteria	L	PFAM transposase IS3 IS911 family protein	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_1079321_1	1210908.HSB1_12720	9.25e-30	110.0	arCOG00516@1|root,arCOG00516@2157|Archaea,2XXT7@28890|Euryarchaeota,23WEB@183963|Halobacteria	183963|Halobacteria	S	flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
k59_189638_1	509191.AEDB02000048_gene4684	2.33e-14	78.6	COG1032@1|root,COG1032@2|Bacteria,1UYAF@1239|Firmicutes,24D1D@186801|Clostridia,3WKPM@541000|Ruminococcaceae	186801|Clostridia	C	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
k59_1413058_1	1123024.AUII01000006_gene4636	9.85e-61	210.0	COG3696@1|root,COG3696@2|Bacteria,2I53X@201174|Actinobacteria,4EE9U@85010|Pseudonocardiales	201174|Actinobacteria	P	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1691171_1	977880.RALTA_B0169	3.86e-74	239.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VI4Q@28216|Betaproteobacteria,1K0B4@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Belongs to the peptidase S1C family	mucD	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
k59_1248030_1	595593.JREV01000007_gene2833	5.25e-33	131.0	COG5283@1|root,COG5283@2|Bacteria,2I8JB@201174|Actinobacteria	201174|Actinobacteria	D	Phage tail tape measure protein, TP901 family	-	-	-	-	-	-	-	-	-	-	-	-	PhageMin_Tail
k59_1357643_1	337075.U4LKS9	7.18e-08	60.5	COG2234@1|root,KOG2195@2759|Eukaryota,38HFE@33154|Opisthokonta,3NV3A@4751|Fungi,3QJAX@4890|Ascomycota	4751|Fungi	O	Belongs to the peptidase M28 family	-	-	3.4.11.15	ko:K01264	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PA,Peptidase_M28
k59_1079337_2	1278073.MYSTI_05205	6.68e-26	106.0	COG4206@1|root,COG4206@2|Bacteria,1QXUW@1224|Proteobacteria,43C7J@68525|delta/epsilon subdivisions,2X7HV@28221|Deltaproteobacteria,2YU5W@29|Myxococcales	28221|Deltaproteobacteria	H	CarboxypepD_reg-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
k59_468906_1	1229780.BN381_130021	1.44e-78	252.0	COG0034@1|root,COG0034@2|Bacteria,2GK6I@201174|Actinobacteria,3UW8X@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
k59_1524265_1	861299.J421_3410	2.47e-09	57.4	COG0528@1|root,COG0528@2|Bacteria,1ZSY2@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
k59_1524265_2	521098.Aaci_1422	1.78e-57	185.0	COG0233@1|root,COG0233@2|Bacteria,1V1F2@1239|Firmicutes,4HFSH@91061|Bacilli,278BF@186823|Alicyclobacillaceae	91061|Bacilli	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
k59_1190787_1	700598.Niako_6669	3.55e-58	192.0	COG0156@1|root,COG0156@2|Bacteria,4NFBU@976|Bacteroidetes,1IP7S@117747|Sphingobacteriia	976|Bacteroidetes	H	Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA	kbl	-	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_1190787_2	76114.ebA6680	8.36e-20	84.7	COG0500@1|root,COG2226@2|Bacteria,1MVIS@1224|Proteobacteria,2VRUU@28216|Betaproteobacteria,2KWI9@206389|Rhodocyclales	206389|Rhodocyclales	Q	ubiE/COQ5 methyltransferase family	-	-	2.1.1.17,2.1.1.71	ko:K00570	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00091	R01320,R02056,R03424	RC00003,RC00060,RC00181,RC00496	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11
k59_468929_1	1454004.AW11_03482	9.03e-56	192.0	COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,2VIRG@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Ferrous iron transport protein B	-	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
k59_358054_1	645465.ACUR01000510_gene377	3.02e-48	165.0	COG2234@1|root,COG2234@2|Bacteria,2I9BM@201174|Actinobacteria	201174|Actinobacteria	G	Peptidase, M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
k59_525322_1	251221.35211385	8.82e-70	239.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
k59_1747636_1	1380394.JADL01000001_gene2360	1.11e-12	73.6	COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,2TVQS@28211|Alphaproteobacteria,2JVHN@204441|Rhodospirillales	204441|Rhodospirillales	P	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
k59_303069_1	682795.AciX8_4752	1.29e-31	127.0	COG1501@1|root,COG1501@2|Bacteria,3Y4C8@57723|Acidobacteria	57723|Acidobacteria	G	Belongs to the glycosyl hydrolase 31 family	-	-	3.2.1.177,3.2.1.20	ko:K01187,ko:K01811	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	DUF4968,DUF5110,Glyco_hydro_31
k59_803390_1	85643.Tmz1t_2948	1.31e-84	258.0	COG1924@1|root,COG1924@2|Bacteria,1R6HU@1224|Proteobacteria,2VSQQ@28216|Betaproteobacteria,2KXX8@206389|Rhodocyclales	206389|Rhodocyclales	I	BadF/BadG/BcrA/BcrD ATPase family	-	-	1.3.7.8	ko:K04115	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R02451	RC00002,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	BcrAD_BadFG
k59_857622_1	105559.Nwat_1912	7.51e-104	317.0	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,1RNI4@1236|Gammaproteobacteria,1WXM2@135613|Chromatiales	135613|Chromatiales	C	TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_303074_1	1435356.Y013_07840	2.4e-73	235.0	COG0160@1|root,COG0160@2|Bacteria,2GJNQ@201174|Actinobacteria,4FV56@85025|Nocardiaceae	201174|Actinobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	lat	-	2.6.1.36	ko:K03918	ko01100,map01100	-	R00457	RC00006,RC00062	ko00000,ko01000,ko01007	-	-	iNJ661.Rv3290c	Aminotran_3
k59_1747640_1	1235803.C825_01171	3.94e-12	68.6	COG1629@1|root,COG1629@2|Bacteria,4NDXS@976|Bacteroidetes,2FKYX@200643|Bacteroidia,22W07@171551|Porphyromonadaceae	976|Bacteroidetes	P	TonB-dependent receptor plug domain	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Plug,STN,TonB_dep_Rec
k59_1747640_2	639282.DEFDS_1130	5.04e-12	68.6	COG4907@1|root,COG4907@2|Bacteria,2GF9W@200930|Deferribacteres	200930|Deferribacteres	S	Predicted membrane protein (DUF2207)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2207
k59_470883_1	383381.EH30_05470	2.5e-78	255.0	COG0046@1|root,COG0046@2|Bacteria,1MYN4@1224|Proteobacteria,2TRGM@28211|Alphaproteobacteria,2K25A@204457|Sphingomonadales	204457|Sphingomonadales	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
k59_747770_1	391896.A1I_05825	1.28e-61	207.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2TQRZ@28211|Alphaproteobacteria,47EZF@766|Rickettsiales	766|Rickettsiales	S	ABC transporter	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_Xtn
k59_1693396_1	465817.ETA_01060	4.08e-23	98.6	COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,1RM8I@1236|Gammaproteobacteria,3X5F7@551|Erwinia	1236|Gammaproteobacteria	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	GO:0003674,GO:0003824,GO:0004807,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iJN746.PP_4715	TIM
k59_1693396_2	1321781.HMPREF1985_01017	3.67e-14	72.0	COG0126@1|root,COG0126@2|Bacteria,1TP3H@1239|Firmicutes,4H6JR@909932|Negativicutes	909932|Negativicutes	F	Belongs to the phosphoglycerate kinase family	pgk	-	-	-	-	-	-	-	-	-	-	-	PGK
k59_1081133_1	1449049.JONW01000009_gene4504	3.24e-75	240.0	COG1215@1|root,COG1215@2|Bacteria,1MXG7@1224|Proteobacteria,2TVZ5@28211|Alphaproteobacteria,2KFD4@204458|Caulobacterales	204458|Caulobacterales	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
k59_1762537_1	1267535.KB906767_gene1957	3.7e-29	121.0	COG0577@1|root,COG0577@2|Bacteria,3Y6MX@57723|Acidobacteria,2JKBK@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_933396_1	319003.Bra1253DRAFT_06988	2.67e-33	123.0	COG1028@1|root,COG1028@2|Bacteria,1MUS7@1224|Proteobacteria,2TTYG@28211|Alphaproteobacteria,3JVR1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	bdh	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
k59_933396_2	1156844.KB891851_gene3976	1.21e-21	89.7	COG0251@1|root,COG0251@2|Bacteria,2IHXH@201174|Actinobacteria	201174|Actinobacteria	J	endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
k59_429806_1	926566.Terro_3652	1.08e-43	154.0	COG0346@1|root,COG0346@2|Bacteria,3Y61Q@57723|Acidobacteria,2JKDJ@204432|Acidobacteriia	204432|Acidobacteriia	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K15975	-	-	-	-	ko00000	-	-	-	Glyoxalase
k59_1266562_1	886377.Murru_3303	9.43e-84	264.0	COG3653@1|root,COG3653@2|Bacteria,4NHDD@976|Bacteroidetes,1HYSX@117743|Flavobacteriia	976|Bacteroidetes	Q	COG3653 N-acyl-D-aspartate D-glutamate deacylase	-	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
k59_1097833_1	1198114.AciX9_1564	0.000842	42.7	COG0612@1|root,COG0612@2|Bacteria,3Y3M9@57723|Acidobacteria,2JHY4@204432|Acidobacteriia	204432|Acidobacteriia	S	Belongs to the peptidase M16 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_1097833_2	273068.TTE1384	1.16e-45	152.0	COG0756@1|root,COG0756@2|Bacteria,1V6HX@1239|Firmicutes,24K3X@186801|Clostridia,42GTP@68295|Thermoanaerobacterales	186801|Clostridia	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	-	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
k59_1044019_1	1380394.JADL01000003_gene5084	9.56e-82	255.0	COG4638@1|root,COG4638@2|Bacteria,1MX47@1224|Proteobacteria,2VG2H@28211|Alphaproteobacteria,2JZP7@204441|Rhodospirillales	204441|Rhodospirillales	P	Rieske [2Fe-2S] domain	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
k59_262119_1	1121929.KB898666_gene2422	1.14e-87	269.0	COG0626@1|root,COG0626@2|Bacteria,1TPC7@1239|Firmicutes,4HBQK@91061|Bacilli	91061|Bacilli	E	Methionine gamma-lyase	-	-	2.5.1.48	ko:K01739	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00420,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
k59_933430_1	1300345.LF41_2410	2.46e-18	84.0	COG2197@1|root,COG2197@2|Bacteria,1NA3X@1224|Proteobacteria	1224|Proteobacteria	KT	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH_3
k59_429847_1	485913.Krac_12226	3.2e-29	119.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	rfaG	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008194,GO:0008610,GO:0008653,GO:0008919,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0046401,GO:0046527,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	-	ko:K02844	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT4	iSDY_1059.SDY_4061	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
k59_709451_1	404589.Anae109_2392	2.1e-14	78.2	COG0454@1|root,COG1022@1|root,COG0456@2|Bacteria,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,42N2G@68525|delta/epsilon subdivisions,2WIXB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	PFAM AMP-dependent synthetase and ligase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding
k59_819241_1	379066.GAU_1646	3.57e-77	243.0	COG0045@1|root,COG0045@2|Bacteria,1ZSZ4@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
k59_1541039_1	335541.Swol_2152	1.47e-12	72.8	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,42KHF@68298|Syntrophomonadaceae	186801|Clostridia	NT	Pfam:Cache_1	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,CHASE3,HAMP,MCPsignal,dCache_1,dCache_3
k59_650588_1	1308866.J416_05293	5.78e-05	48.5	COG1234@1|root,COG1234@2|Bacteria,1TRGP@1239|Firmicutes,4HABM@91061|Bacilli,46ZX6@74385|Gracilibacillus	91061|Bacilli	S	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA	rnz	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0031123,GO:0034414,GO:0034470,GO:0034641,GO:0034660,GO:0042779,GO:0042780,GO:0042781,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1905267	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B,Lactamase_B_2
k59_650588_2	159450.NH14_17795	2.7e-08	54.3	COG1387@1|root,COG1387@2|Bacteria,1MYXV@1224|Proteobacteria,2VJIQ@28216|Betaproteobacteria,1K4RW@119060|Burkholderiaceae	28216|Betaproteobacteria	L	DNA polymerase	-	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP
k59_1097871_1	948106.AWZT01000005_gene4477	3.58e-77	240.0	COG0331@1|root,COG0331@2|Bacteria,1MV6N@1224|Proteobacteria,2VJF7@28216|Betaproteobacteria,1K35C@119060|Burkholderiaceae	28216|Betaproteobacteria	I	malonyl CoA-acyl carrier protein transacylase	fabD	-	2.3.1.39	ko:K00645,ko:K15355	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
k59_1710613_1	318167.Sfri_0277	4.64e-61	200.0	COG2177@1|root,COG2177@2|Bacteria,1MU65@1224|Proteobacteria,1RYBV@1236|Gammaproteobacteria,2QAA7@267890|Shewanellaceae	1236|Gammaproteobacteria	D	Part of the ABC transporter FtsEX involved in cellular division	ftsX	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0009274,GO:0009276,GO:0009987,GO:0016020,GO:0016021,GO:0030312,GO:0030313,GO:0031224,GO:0031975,GO:0032153,GO:0044425,GO:0044464,GO:0051301,GO:0071944	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	FtsX
k59_709471_1	1121374.KB891583_gene2884	6.93e-156	454.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,1RR2W@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	COG3666 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_763319_1	349521.HCH_02566	7.69e-47	155.0	COG3293@1|root,COG3293@2|Bacteria,1R5NV@1224|Proteobacteria,1SZ5P@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
k59_763319_2	1144275.COCOR_04404	5.26e-42	146.0	COG3293@1|root,COG3293@2|Bacteria,1R5NV@1224|Proteobacteria,42UQV@68525|delta/epsilon subdivisions,2WQC0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Putative transposase of IS4/5 family (DUF4096)	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4096
k59_374515_1	977880.RALTA_B1472	8.73e-28	113.0	COG0318@1|root,COG0764@1|root,COG0318@2|Bacteria,COG0764@2|Bacteria,1MXPB@1224|Proteobacteria,2VJ3A@28216|Betaproteobacteria,1KH0W@119060|Burkholderiaceae	28216|Betaproteobacteria	IQ	AMP-binding enzyme	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,FabA
k59_374515_2	365046.Rta_02530	9.31e-17	79.0	COG4648@1|root,COG4648@2|Bacteria,1RII0@1224|Proteobacteria,2VSMC@28216|Betaproteobacteria,4AFJS@80864|Comamonadaceae	28216|Betaproteobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_819278_1	1121920.AUAU01000019_gene2603	1.35e-34	133.0	COG2433@1|root,COG2433@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K12065	-	-	-	-	ko00000,ko02044	3.A.7.11.1	-	-	Porin_O_P
k59_987784_1	880074.BARVI_07305	9.61e-21	96.3	COG1283@1|root,COG1283@2|Bacteria,4NHMY@976|Bacteroidetes,2FMJB@200643|Bacteroidia,22WCR@171551|Porphyromonadaceae	976|Bacteroidetes	P	Na Pi-cotransporter II-like protein	-	-	-	ko:K03324	-	-	-	-	ko00000,ko02000	2.A.58.2	-	-	Na_Pi_cotrans,PhoU
k59_262187_1	383372.Rcas_3190	6.93e-16	83.6	COG0728@1|root,COG0728@2|Bacteria,2G5MD@200795|Chloroflexi,37596@32061|Chloroflexia	32061|Chloroflexia	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	-	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
k59_1266650_1	1347342.BN863_24050	1.52e-72	235.0	COG0441@1|root,COG0441@2|Bacteria,4NEFT@976|Bacteroidetes,1HX1R@117743|Flavobacteriia	976|Bacteroidetes	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
k59_1266650_2	398720.MED217_15030	8.76e-05	44.7	COG0270@1|root,COG0270@2|Bacteria,4NG9I@976|Bacteroidetes	976|Bacteroidetes	H	Cytosine-specific methyltransferase	-	-	2.1.1.37	ko:K00558	ko00270,ko01100,ko05206,map00270,map01100,map05206	M00035	R04858	RC00003,RC00332	ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_methylase
k59_374527_1	379066.GAU_0027	2.27e-61	201.0	COG1475@1|root,COG1475@2|Bacteria,1ZSKT@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	ParB-like nuclease domain	-	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
k59_1044128_2	1267534.KB906754_gene3465	7.46e-29	114.0	COG0491@1|root,COG0491@2|Bacteria,3Y54H@57723|Acidobacteria,2JM9F@204432|Acidobacteriia	204432|Acidobacteriia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_1541110_1	1158606.I579_01573	1.49e-13	75.5	COG1234@1|root,COG1234@2|Bacteria,1V1TF@1239|Firmicutes,4HFNV@91061|Bacilli,4AZQ3@81852|Enterococcaceae	91061|Bacilli	S	Metallo-beta-lactamase superfamily	yhfI	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0031123,GO:0034414,GO:0034470,GO:0034641,GO:0034660,GO:0042779,GO:0042780,GO:0042781,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1905267	-	-	-	-	-	-	-	-	-	-	Lactamase_B,Lactamase_B_2
k59_1266678_1	869213.JCM21142_3989	4.32e-91	298.0	COG0841@1|root,COG0841@2|Bacteria,4NDZG@976|Bacteroidetes	976|Bacteroidetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1153743_1	502025.Hoch_2606	1.67e-40	150.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2YUJU@29|Myxococcales	28221|Deltaproteobacteria	T	response regulator	-	-	-	ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_596427_1	1379270.AUXF01000003_gene3556	1.27e-87	276.0	COG0443@1|root,COG0443@2|Bacteria,1ZT75@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
k59_1541117_1	990073.ATHU01000001_gene1543	1.45e-13	70.9	COG1360@1|root,COG1360@2|Bacteria,1MU4S@1224|Proteobacteria,42Q7D@68525|delta/epsilon subdivisions,2YMSU@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	N	Membrane MotB of proton-channel complex MotA/MotB	motS	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotB_plug,OmpA
k59_1541117_2	765911.Thivi_4360	1.83e-11	65.5	28K7D@1|root,2Z9VI@2|Bacteria,1R8BZ@1224|Proteobacteria,1S0U2@1236|Gammaproteobacteria,1WXW5@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_206196_2	583345.Mmol_1393	4.2e-52	178.0	COG4965@1|root,COG4965@2|Bacteria,1MUXK@1224|Proteobacteria,2VJ80@28216|Betaproteobacteria,2KN95@206350|Nitrosomonadales	206350|Nitrosomonadales	U	Type II secretion system (T2SS), protein F	-	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
k59_1430934_1	1163407.UU7_14810	3.25e-09	58.5	COG1609@1|root,COG1609@2|Bacteria,1MVUR@1224|Proteobacteria,1RN2K@1236|Gammaproteobacteria,1X3V1@135614|Xanthomonadales	135614|Xanthomonadales	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	LacI,Peripla_BP_3
k59_1321337_1	1173020.Cha6605_5319	5.34e-29	115.0	COG1597@1|root,COG1597@2|Bacteria,1G0MV@1117|Cyanobacteria	1117|Cyanobacteria	I	PFAM Diacylglycerol kinase, catalytic	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
k59_1762699_1	278957.ABEA03000176_gene2790	3.75e-24	96.7	COG0614@1|root,COG0614@2|Bacteria,46XU2@74201|Verrucomicrobia,3K9Q9@414999|Opitutae	414999|Opitutae	P	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
k59_1430937_1	406552.NJ7G_0766	2.64e-17	84.7	COG0277@1|root,arCOG00340@2157|Archaea,2Y85H@28890|Euryarchaeota,24157@183963|Halobacteria	183963|Halobacteria	C	COG0277 FAD FMN-containing dehydrogenases	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
k59_987883_1	536019.Mesop_4588	7.43e-10	63.2	COG0697@1|root,COG0697@2|Bacteria,1R6KH@1224|Proteobacteria,2TTBR@28211|Alphaproteobacteria,43IEN@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	EG	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	MA20_23245	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_1710741_2	865937.Gilli_1846	2.68e-128	398.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,4NGU2@976|Bacteroidetes,1HYJJ@117743|Flavobacteriia	976|Bacteroidetes	M	Tricorn protease homolog	-	-	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
k59_541212_1	861299.J421_3855	4.73e-12	63.9	COG0740@1|root,COG0740@2|Bacteria,1ZSPR@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
k59_541212_2	379066.GAU_2409	6.05e-26	110.0	COG0544@1|root,COG0544@2|Bacteria,1ZSSF@142182|Gemmatimonadetes	142182|Gemmatimonadetes	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	-	-	ko:K03545	-	-	-	-	ko00000	-	-	-	Trigger_C,Trigger_N
k59_987909_1	404589.Anae109_1874	7.81e-77	245.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,42MSP@68525|delta/epsilon subdivisions,2WIUZ@28221|Deltaproteobacteria,2YUCI@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
k59_596461_1	1100721.ALKO01000003_gene2070	2.44e-55	188.0	COG4638@1|root,COG4638@2|Bacteria,1MWXW@1224|Proteobacteria,2VM92@28216|Betaproteobacteria,4ACS4@80864|Comamonadaceae	28216|Betaproteobacteria	P	Rieske 2Fe-2S domain protein	nagG	-	1.14.12.1,1.14.13.172	ko:K16319,ko:K18242	ko00626,ko00627,ko01120,map00626,map00627,map01120	M00637,M00638	R00823,R00825,R07709,R07710	RC00192,RC00490	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske,Ring_hydroxyl_A
k59_206226_1	671143.DAMO_3055	1.25e-34	136.0	COG0577@1|root,COG4591@1|root,COG0577@2|Bacteria,COG4591@2|Bacteria,2NQQA@2323|unclassified Bacteria	2|Bacteria	V	MacB-like periplasmic core domain	lolE-2	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_1046500_1	391038.Bphy_1094	1.04e-47	162.0	COG0517@1|root,COG0517@2|Bacteria,1RE9W@1224|Proteobacteria,2VRIH@28216|Betaproteobacteria,1K4C0@119060|Burkholderiaceae	28216|Betaproteobacteria	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	BON,CBS
k59_1378628_1	744985.HIMB59_00005210	2.38e-24	97.8	COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,2TSH9@28211|Alphaproteobacteria,4BPBF@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	P	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system	tauB	-	3.6.3.36	ko:K02049,ko:K10831	ko00920,ko02010,map00920,map02010	M00188,M00435	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.16,3.A.1.17,3.A.1.17.1,3.A.1.17.4	-	-	ABC_tran
k59_1378628_2	744985.HIMB59_00005220	7.87e-56	181.0	COG0600@1|root,COG0600@2|Bacteria,1NJ59@1224|Proteobacteria,2TUZ1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	ABC-type nitrate sulfonate bicarbonate transport system permease component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
k59_1378629_1	1382356.JQMP01000003_gene2113	8.55e-64	208.0	COG1960@1|root,COG1960@2|Bacteria,2G65J@200795|Chloroflexi,27Y45@189775|Thermomicrobia	189775|Thermomicrobia	C	Acyl- CoA dehydrogenase type 2 domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_1100381_1	1347393.HG726020_gene829	5.69e-49	173.0	COG2270@1|root,COG2270@2|Bacteria,4PM3J@976|Bacteroidetes,2FQ2T@200643|Bacteroidia,4AP4Z@815|Bacteroidaceae	976|Bacteroidetes	S	Transmembrane secretion effector	-	-	-	ko:K08217	-	-	-	-	br01600,ko00000,ko01504,ko02000	2.A.1.21.1,2.A.1.21.22	-	-	MFS_1,MFS_3
k59_821734_1	215803.DB30_2967	1.19e-74	235.0	2C57D@1|root,2Z7RS@2|Bacteria,1MX6G@1224|Proteobacteria,42Y78@68525|delta/epsilon subdivisions,2X3CW@28221|Deltaproteobacteria,2YUS0@29|Myxococcales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF2891)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2891
k59_377169_1	706587.Desti_3607	1.94e-140	409.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,42M7A@68525|delta/epsilon subdivisions,2WJ8P@28221|Deltaproteobacteria,2MR6S@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	TIGRFAM glutamine synthetase, type I	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
k59_876906_2	315456.RF_0079	1.59e-08	57.8	COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,2TQKD@28211|Alphaproteobacteria,47F2Y@766|Rickettsiales	766|Rickettsiales	E	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
k59_99073_1	1448139.AI20_08100	3.65e-16	82.8	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
k59_1269280_1	1131269.AQVV01000005_gene372	3.58e-72	235.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	nadE	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.1.5,6.3.5.1	ko:K01916,ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00189,R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
k59_1156324_1	1354722.JQLS01000005_gene3850	1.31e-80	253.0	COG2271@1|root,COG2271@2|Bacteria,1QVY6@1224|Proteobacteria,2TVPK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1653791_1	1205680.CAKO01000040_gene697	2.51e-15	72.4	COG1329@1|root,COG1329@2|Bacteria,1MWI2@1224|Proteobacteria,2TTVP@28211|Alphaproteobacteria,2JRY7@204441|Rhodospirillales	204441|Rhodospirillales	K	transcriptional regulator	ydeB	-	-	ko:K07736	-	-	-	-	ko00000,ko03000	-	-	-	CarD_CdnL_TRCF
k59_1653791_2	1430440.MGMSRv2_3122	1.45e-27	108.0	COG0639@1|root,COG0639@2|Bacteria,1NPR1@1224|Proteobacteria,2U19D@28211|Alphaproteobacteria,2JPXQ@204441|Rhodospirillales	204441|Rhodospirillales	T	COG0639 Diadenosine tetraphosphatase and related serine threonine protein phosphatases	-	-	3.1.3.16	ko:K07313	-	-	-	-	ko00000,ko01000	-	-	-	-
k59_652935_1	1123320.KB889677_gene2786	1.13e-09	63.5	COG2197@1|root,COG2197@2|Bacteria,2GMUG@201174|Actinobacteria	201174|Actinobacteria	T	Two component transcriptional regulator, LuxR family	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_765488_1	1049564.TevJSym_aj00250	2.37e-106	317.0	COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,1RMXY@1236|Gammaproteobacteria,1J4FB@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	GO:0000166,GO:0003674,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008144,GO:0008150,GO:0009898,GO:0009987,GO:0016020,GO:0017076,GO:0030554,GO:0032153,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0051301,GO:0071944,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
k59_1765252_1	69395.JQLZ01000001_gene3081	5.94e-37	141.0	COG1174@1|root,COG1732@1|root,COG1174@2|Bacteria,COG1732@2|Bacteria,1MXA1@1224|Proteobacteria,2TUNH@28211|Alphaproteobacteria,2KFTB@204458|Caulobacterales	204458|Caulobacterales	P	of ABC-type glycine betaine transport system	-	-	-	ko:K05845,ko:K05846	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1,OpuAC
k59_1378673_1	243231.GSU2863	1.5e-74	252.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,43DMZ@68525|delta/epsilon subdivisions,2WIW5@28221|Deltaproteobacteria,43T41@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_99099_1	1192034.CAP_7003	3.21e-76	240.0	COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,42M67@68525|delta/epsilon subdivisions,2WJQX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Cys Met metabolism	-	-	2.5.1.48,4.4.1.11,4.4.1.8	ko:K01739,ko:K01760,ko:K01761	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00654,R00782,R00999,R01286,R01288,R02408,R02508,R03217,R03260,R04770,R04941,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00196,RC00348,RC00382,RC00420,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
k59_432421_1	1144305.PMI02_05037	1.04e-19	90.1	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,2U1Z0@28211|Alphaproteobacteria,2KAWY@204457|Sphingomonadales	204457|Sphingomonadales	L	Group II intron, maturase-specific domain	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k59_208218_1	1123258.AQXZ01000018_gene837	2.15e-22	101.0	COG0477@1|root,COG2814@2|Bacteria,2GIZX@201174|Actinobacteria,4FUCD@85025|Nocardiaceae	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_821780_1	1170562.Cal6303_3568	6.99e-24	103.0	COG0515@1|root,COG0642@1|root,COG3899@1|root,COG0515@2|Bacteria,COG2205@2|Bacteria,COG3899@2|Bacteria,1GBKM@1117|Cyanobacteria,1HJ09@1161|Nostocales	1117|Cyanobacteria	KLT	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GAF,HATPase_c,HisKA,PAS_3,PAS_9,Pkinase,Response_reg
k59_821780_2	926569.ANT_11840	1.45e-78	235.0	COG0784@1|root,COG0784@2|Bacteria,2G9B3@200795|Chloroflexi	200795|Chloroflexi	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
k59_1600756_1	1395587.P364_0103720	6.36e-10	64.7	COG1028@1|root,COG1028@2|Bacteria,1TSNP@1239|Firmicutes,4IPV4@91061|Bacilli,26RT2@186822|Paenibacillaceae	91061|Bacilli	IQ	KR domain	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_598464_1	479434.Sthe_1273	2.78e-72	233.0	COG0277@1|root,COG0277@2|Bacteria	2|Bacteria	C	FAD linked oxidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
k59_1210841_1	1121468.AUBR01000001_gene479	3.31e-22	99.8	COG1032@1|root,COG1032@2|Bacteria,1TPGT@1239|Firmicutes,247JS@186801|Clostridia,42FJE@68295|Thermoanaerobacterales	186801|Clostridia	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4080,Radical_SAM
k59_1543158_1	1191523.MROS_1330	6.4e-27	113.0	COG0366@1|root,COG0366@2|Bacteria	2|Bacteria	G	hydrolase activity, hydrolyzing O-glycosyl compounds	amyA	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase
k59_444195_2	290397.Adeh_0731	9.11e-09	57.4	COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,42MP8@68525|delta/epsilon subdivisions,2WKMR@28221|Deltaproteobacteria,2YUYM@29|Myxococcales	28221|Deltaproteobacteria	H	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
k59_53778_1	1121930.AQXG01000010_gene3076	1.22e-38	135.0	COG0702@1|root,COG0702@2|Bacteria,4NMGY@976|Bacteroidetes,1IXBD@117747|Sphingobacteriia	976|Bacteroidetes	GM	NAD(P)H-binding	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10
k59_663938_1	926569.ANT_16630	4.8e-48	166.0	COG0820@1|root,COG0820@2|Bacteria,2G5SD@200795|Chloroflexi	200795|Chloroflexi	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Radical_SAM
k59_217890_2	1386089.N865_21410	6.59e-06	50.4	COG0265@1|root,COG0265@2|Bacteria,2GJ96@201174|Actinobacteria,4FEHF@85021|Intrasporangiaceae	201174|Actinobacteria	O	PDZ domain (Also known as DHR or GLGF)	degP	-	-	ko:K08372	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Trypsin_2
k59_53789_1	1123371.ATXH01000003_gene1947	4.24e-36	132.0	COG1624@1|root,COG1624@2|Bacteria,2GID9@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	DisA bacterial checkpoint controller nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	DisA_N
k59_165940_1	1280001.BAOA01000132_gene1258	1.02e-37	130.0	COG0346@1|root,COG0346@2|Bacteria,1N116@1224|Proteobacteria,1S4X5@1236|Gammaproteobacteria,1XWYD@135623|Vibrionales	135623|Vibrionales	E	COG0346 Lactoylglutathione lyase and related lyases	-	-	-	ko:K07032	-	-	-	-	ko00000	-	-	-	Glyoxalase
k59_833522_1	1121033.AUCF01000003_gene3327	5.87e-32	122.0	COG0726@1|root,COG0726@2|Bacteria,1R5QW@1224|Proteobacteria,2TTV0@28211|Alphaproteobacteria,2JS3M@204441|Rhodospirillales	204441|Rhodospirillales	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1220944_1	339671.Asuc_0633	1.76e-32	125.0	COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,1RP4T@1236|Gammaproteobacteria,1Y7H3@135625|Pasteurellales	135625|Pasteurellales	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	Z012_07185	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_1665139_1	570967.JMLV01000009_gene1005	4.37e-103	315.0	COG1866@1|root,COG1866@2|Bacteria,1MWXN@1224|Proteobacteria,2TRC4@28211|Alphaproteobacteria,2JQSD@204441|Rhodospirillales	204441|Rhodospirillales	C	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA	pckA	-	4.1.1.49	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00170	R00341	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_ATP
k59_1445130_1	926569.ANT_31010	7.13e-72	222.0	COG0528@1|root,COG0528@2|Bacteria,2G5RG@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
k59_217956_1	1192034.CAP_8694	1.29e-71	236.0	COG0318@1|root,COG0318@2|Bacteria,1MW0Y@1224|Proteobacteria,42SEI@68525|delta/epsilon subdivisions,2WPEN@28221|Deltaproteobacteria,2YY7E@29|Myxococcales	28221|Deltaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	menE	-	6.2.1.26	ko:K01911	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R04030	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	AMP-binding,AMP-binding_C
k59_217956_2	1445613.JALM01000005_gene1214	5.69e-06	49.3	COG0824@1|root,COG0824@2|Bacteria,2IINH@201174|Actinobacteria,4E74I@85010|Pseudonocardiales	201174|Actinobacteria	S	Thioesterase-like superfamily	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
k59_444306_1	639282.DEFDS_0387	3.68e-24	95.1	COG1669@1|root,COG1669@2|Bacteria	2|Bacteria	S	nucleotidyltransferase activity	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	NTP_transf_2
k59_775903_1	981383.AEWH01000035_gene898	4.4e-73	241.0	COG0542@1|root,COG0542@2|Bacteria,1TPMU@1239|Firmicutes,4HACY@91061|Bacilli	91061|Bacilli	O	Belongs to the ClpA ClpB family	clpC	GO:0006950,GO:0008150,GO:0010035,GO:0010038,GO:0042221,GO:0046686,GO:0046688,GO:0050896,GO:0097501,GO:1990169,GO:1990170	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
k59_1611873_1	794903.OPIT5_16120	2.22e-88	273.0	COG1509@1|root,COG1509@2|Bacteria,46SVQ@74201|Verrucomicrobia,3K7P6@414999|Opitutae	414999|Opitutae	C	lysine 2,3-aminomutase	-	-	5.4.3.2	ko:K01843	ko00310,map00310	-	R00461	RC00303	ko00000,ko00001,ko01000	-	-	-	LAM_C,Radical_SAM
k59_775914_2	446471.Xcel_0988	1.03e-12	67.4	COG1053@1|root,COG1053@2|Bacteria,2GJ45@201174|Actinobacteria,4F3VF@85017|Promicromonosporaceae	201174|Actinobacteria	C	Fumarate reductase flavoprotein C-term	sdhA	GO:0000104,GO:0000166,GO:0001539,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0006113,GO:0006928,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016491,GO:0016627,GO:0022607,GO:0022900,GO:0030030,GO:0030031,GO:0032991,GO:0033554,GO:0036094,GO:0040011,GO:0043167,GO:0043168,GO:0044085,GO:0044237,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0044780,GO:0044781,GO:0045273,GO:0045274,GO:0045283,GO:0045284,GO:0045333,GO:0048037,GO:0048870,GO:0050660,GO:0050662,GO:0050896,GO:0051179,GO:0051674,GO:0051716,GO:0055114,GO:0070469,GO:0070470,GO:0070925,GO:0071840,GO:0071944,GO:0071949,GO:0071973,GO:0097159,GO:0097588,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363	1.3.5.1,1.3.5.4,1.4.3.16	ko:K00239,ko:K00244,ko:K00278	ko00020,ko00190,ko00250,ko00620,ko00650,ko00720,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,ko05134,map00020,map00190,map00250,map00620,map00650,map00720,map00760,map01100,map01110,map01120,map01130,map01200,map02020,map05134	M00009,M00011,M00115,M00149,M00150,M00173,M00374,M00376	R00357,R00481,R02164	RC00006,RC00045,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_833621_1	1340493.JNIF01000004_gene292	1.43e-24	107.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_553896_1	1210884.HG799463_gene10216	4.45e-46	163.0	COG0448@1|root,COG0448@2|Bacteria,2IWRQ@203682|Planctomycetes	203682|Planctomycetes	H	Belongs to the bacterial plant glucose-1-phosphate adenylyltransferase family	-	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
k59_166035_1	32049.SYNPCC7002_A0893	4.03e-109	333.0	COG3211@1|root,COG3211@2|Bacteria,1GD52@1117|Cyanobacteria,1H47D@1129|Synechococcus	1117|Cyanobacteria	S	Bacterial protein of unknown function (DUF839)	-	-	-	ko:K07093	-	-	-	-	ko00000	-	-	-	DUF839
k59_274596_1	866536.Belba_1571	3.6e-85	268.0	COG3867@1|root,COG3867@2|Bacteria,4NI3G@976|Bacteroidetes,47MXH@768503|Cytophagia	976|Bacteroidetes	G	Arabinogalactan	-	-	3.2.1.89	ko:K01224	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_hydro_53
k59_53934_1	1123517.JOMR01000001_gene1684	2.67e-33	127.0	COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,1RPCE@1236|Gammaproteobacteria,4605K@72273|Thiotrichales	72273|Thiotrichales	M	Glycosyl transferase family 2	-	-	-	ko:K20534	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.2.1.9	GT2	-	Glycos_transf_2
k59_775940_1	1415779.JOMH01000001_gene1367	8.88e-14	75.5	COG0657@1|root,COG0657@2|Bacteria,1Q14N@1224|Proteobacteria,1RZIY@1236|Gammaproteobacteria,1X7DR@135614|Xanthomonadales	135614|Xanthomonadales	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
k59_664121_1	1343739.PAP_06885	8.42e-44	158.0	COG1850@1|root,arCOG04443@2157|Archaea,2XVBP@28890|Euryarchaeota,242KB@183968|Thermococci	183968|Thermococci	G	Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase	rbcL	-	4.1.1.39	ko:K01601	ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200	M00165,M00166,M00532	R00024,R03140	RC00172,RC00859	ko00000,ko00001,ko00002,ko01000	-	-	-	RuBisCO_large,RuBisCO_large_N
k59_1611941_1	351607.Acel_0891	2.01e-64	202.0	COG2128@1|root,COG2128@2|Bacteria,2HTUG@201174|Actinobacteria,4EUKU@85013|Frankiales	201174|Actinobacteria	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_664129_1	861299.J421_2469	6.18e-81	261.0	COG0646@1|root,COG0685@1|root,COG0646@2|Bacteria,COG0685@2|Bacteria,1ZT6C@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Methylenetetrahydrofolate reductase	-	-	1.5.1.20,2.1.1.10	ko:K00297,ko:K00547	ko00270,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01523,map00270,map00670,map00720,map01100,map01110,map01120,map01200,map01523	M00377	R00650,R01224,R07168	RC00003,RC00035,RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR,S-methyl_trans
k59_1553387_1	1247963.JPHU01000012_gene933	2.85e-90	286.0	COG1680@1|root,COG1680@2|Bacteria,1NHIY@1224|Proteobacteria,2U0A3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	Beta-lactamase class C and other penicillin binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_166098_1	926569.ANT_15310	2.18e-67	216.0	COG0466@1|root,COG0466@2|Bacteria,2G5TZ@200795|Chloroflexi	200795|Chloroflexi	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_775984_1	861299.J421_2771	2.31e-135	404.0	COG0480@1|root,COG0480@2|Bacteria,1ZT9G@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_1445282_1	240302.BN982_00104	1.72e-31	126.0	COG1884@1|root,COG1884@2|Bacteria,1TQAD@1239|Firmicutes,4H9QB@91061|Bacilli,3NENI@45667|Halobacillus	91061|Bacilli	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
k59_1722291_2	247490.KSU1_B0604	6.84e-07	51.6	2EABA@1|root,334FH@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	TIG
k59_444428_1	521045.Kole_1509	1.09e-31	126.0	COG1173@1|root,COG4171@1|root,COG1173@2|Bacteria,COG4171@2|Bacteria,2GC1J@200918|Thermotogae	200918|Thermotogae	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
k59_388547_1	225849.swp_0941	1.45e-15	74.3	COG1863@1|root,COG1863@2|Bacteria,1MZYJ@1224|Proteobacteria,1S7Z3@1236|Gammaproteobacteria,2QBMS@267890|Shewanellaceae	1236|Gammaproteobacteria	P	PFAM cation antiporter	mnhE	-	-	ko:K05569	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MNHE
k59_388547_2	998674.ATTE01000001_gene739	2.47e-28	104.0	COG2212@1|root,COG2212@2|Bacteria,1N6VV@1224|Proteobacteria,1SE40@1236|Gammaproteobacteria,462U9@72273|Thiotrichales	72273|Thiotrichales	P	Multiple resistance and pH regulation protein F (MrpF / PhaF)	-	-	-	ko:K05570	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MrpF_PhaF
k59_1553433_1	1123376.AUIU01000013_gene1779	2.26e-30	110.0	COG1586@1|root,COG1586@2|Bacteria,3J15H@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine	speH	-	4.1.1.50	ko:K01611	ko00270,ko00330,ko01100,map00270,map00330,map01100	M00034,M00133	R00178	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_dc
k59_1445323_1	398767.Glov_1939	9.35e-56	185.0	COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,42MU6@68525|delta/epsilon subdivisions,2WIJN@28221|Deltaproteobacteria,43S1E@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH-2	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
k59_1221111_1	911045.PSE_2213	6.48e-27	103.0	COG0454@1|root,COG0456@2|Bacteria,1N3HD@1224|Proteobacteria,2UC5X@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	-	-	-	ko:K03826,ko:K03827	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
k59_388572_1	452637.Oter_3359	1.62e-59	206.0	COG1643@1|root,COG1643@2|Bacteria,46TMT@74201|Verrucomicrobia,3K7J2@414999|Opitutae	414999|Opitutae	L	ATP-dependent helicase C-terminal	-	-	3.6.4.13	ko:K03579	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HA2,Helicase_C,HrpB_C
k59_833782_1	591167.Sfla_3004	9.9e-58	198.0	COG3119@1|root,COG3119@2|Bacteria,2GJ8H@201174|Actinobacteria	201174|Actinobacteria	P	Pfam Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
k59_166182_1	89187.ISM_14425	1.8e-57	196.0	COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,2TVYU@28211|Alphaproteobacteria,46RUJ@74030|Roseovarius	28211|Alphaproteobacteria	EQ	Hydantoinase B/oxoprolinase	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
k59_167709_2	926569.ANT_17260	3.16e-39	143.0	COG0161@1|root,COG0161@2|Bacteria	2|Bacteria	H	adenosylmethionine-8-amino-7-oxononanoate transaminase activity	-	-	2.6.1.55	ko:K15372	ko00410,ko00430,ko01100,map00410,map00430,map01100	-	R00908,R01684	RC00006,RC00062	ko00000,ko00001,ko01000	-	-	-	Aminotran_3
k59_1001644_1	1187851.A33M_2089	9.31e-59	203.0	COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,2TS8V@28211|Alphaproteobacteria,3FDQ6@34008|Rhodovulum	28211|Alphaproteobacteria	Q	FtsX-like permease family	MA20_43810	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_1501960_1	926569.ANT_09170	6.56e-79	265.0	COG1956@1|root,COG2202@1|root,COG2203@1|root,COG2770@1|root,COG3437@1|root,COG1956@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2770@2|Bacteria,COG3437@2|Bacteria,2G7KX@200795|Chloroflexi	2|Bacteria	T	HD domain	yebR	-	1.8.4.14,3.1.3.3,4.6.1.1	ko:K01768,ko:K02584,ko:K02660,ko:K07315,ko:K08968,ko:K17763	ko00230,ko00270,ko02020,ko02025,ko04113,ko04213,map00230,map00270,map02020,map02025,map04113,map04213	M00695	R00089,R00434,R02025	RC00295,RC00639	ko00000,ko00001,ko00002,ko01000,ko02035,ko02044,ko03000,ko03021	-	-	-	GAF,GAF_2,GGDEF,HATPase_c,HD_5,HisKA,PAS,PAS_3,PAS_4,PAS_9,STAS,SpoIIE,dCache_1
k59_612445_1	290397.Adeh_4307	2.57e-110	343.0	COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,42P3K@68525|delta/epsilon subdivisions,2WMB8@28221|Deltaproteobacteria,2YWYR@29|Myxococcales	28221|Deltaproteobacteria	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
k59_1224063_1	861299.J421_6081	8.65e-85	264.0	COG4948@1|root,COG4948@2|Bacteria,1ZUQN@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB)	-	-	4.2.1.113	ko:K02549	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R04031	RC01053	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
k59_501259_1	1502851.FG93_03252	2.92e-12	72.0	COG1999@1|root,COG2010@1|root,COG1999@2|Bacteria,COG2010@2|Bacteria,1MYNE@1224|Proteobacteria,2V9Z1@28211|Alphaproteobacteria,3K5DU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
k59_834848_2	1235792.C808_05031	4.56e-05	50.8	COG0463@1|root,COG0463@2|Bacteria,1UP84@1239|Firmicutes,25H8A@186801|Clostridia,27UJW@186928|unclassified Lachnospiraceae	2|Bacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1,Glycos_transf_2
k59_556843_1	292564.Cyagr_3091	5.61e-40	144.0	COG0604@1|root,COG0604@2|Bacteria,1G0N4@1117|Cyanobacteria,22SHW@167375|Cyanobium	1117|Cyanobacteria	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
k59_723735_1	926569.ANT_14720	1.07e-87	272.0	COG1109@1|root,COG1109@2|Bacteria,2G5Y4@200795|Chloroflexi	200795|Chloroflexi	G	phosphoglucomutase phosphomannomutase alpha beta alpha domain I	-	-	5.4.2.8	ko:K01840	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01818	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_1724357_1	1120960.ATXG01000001_gene844	2.78e-51	171.0	COG0702@1|root,COG0702@2|Bacteria,2I234@201174|Actinobacteria,4FQJE@85023|Microbacteriaceae	201174|Actinobacteria	GM	NAD(P)H-binding	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10
k59_445737_1	439235.Dalk_0497	8.29e-78	256.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,42MPZ@68525|delta/epsilon subdivisions,2WIR9@28221|Deltaproteobacteria,2MHQG@213118|Desulfobacterales	28221|Deltaproteobacteria	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
k59_668101_1	1451261.AS96_07920	4.8e-157	461.0	COG0364@1|root,COG0364@2|Bacteria,2GISI@201174|Actinobacteria,4FKKW@85023|Microbacteriaceae	201174|Actinobacteria	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
k59_1168452_1	189753.AXAS01000084_gene6056	5.68e-51	183.0	COG2114@1|root,COG3629@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3629@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,3JTQ7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,DZR,Guanylate_cyc,SAM_1,Trans_reg_C
k59_278885_1	551789.ATVJ01000003_gene380	2.02e-35	137.0	COG1520@1|root,COG2010@1|root,COG1520@2|Bacteria,COG2010@2|Bacteria,1PIDE@1224|Proteobacteria,2TTS3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	PQQ-like domain	-	-	1.1.2.6	ko:K05889	-	-	R03136	-	ko00000,ko01000	-	-	-	Cytochrome_CBB3,PQQ,PQQ_2,PQQ_3
k59_834868_1	379066.GAU_1727	7.56e-43	152.0	COG0547@1|root,COG0547@2|Bacteria,1ZTDS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18	ko:K00766	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R01073	RC00440	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
k59_834868_2	751945.Theos_0401	5.77e-31	121.0	COG0101@1|root,COG0101@2|Bacteria,1WJ4J@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
k59_1613163_1	237368.SCABRO_03677	3.62e-73	232.0	COG0156@1|root,COG0156@2|Bacteria,2IX0H@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA	kbl	-	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_223332_1	1415778.JQMM01000001_gene1963	1.46e-78	250.0	COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,1RNE4@1236|Gammaproteobacteria,1J4XQ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Acts as a magnesium transporter	mgtE	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
k59_1668811_1	682795.AciX8_0881	5.04e-36	140.0	COG3250@1|root,COG3250@2|Bacteria,3Y6RC@57723|Acidobacteria,2JKAB@204432|Acidobacteriia	204432|Acidobacteriia	G	alpha-L-rhamnosidase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_106
k59_1446494_1	543728.Vapar_5479	1.2e-81	259.0	COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,2VM9R@28216|Betaproteobacteria,4AD4V@80864|Comamonadaceae	28216|Betaproteobacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	korC	-	-	-	-	-	-	-	-	-	-	-	Fer4_20,Fer4_7,Pyr_redox_2,Pyr_redox_3
k59_1279674_2	420662.Mpe_A3017	6.24e-10	59.3	COG1428@1|root,COG1428@2|Bacteria,1RC50@1224|Proteobacteria,2VQ8U@28216|Betaproteobacteria	28216|Betaproteobacteria	F	Deoxynucleoside kinase	dgk	-	-	-	-	-	-	-	-	-	-	-	dNK
k59_501307_1	1117108.PAALTS15_25374	2.24e-11	63.5	COG0470@1|root,COG0470@2|Bacteria,1V0N0@1239|Firmicutes,4HD0I@91061|Bacilli,26UY6@186822|Paenibacillaceae	91061|Bacilli	L	DNA polymerase III	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_612506_1	197221.22294882	4.97e-35	137.0	COG0841@1|root,COG0841@2|Bacteria,1G0C2@1117|Cyanobacteria	1117|Cyanobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_668139_1	1038860.AXAP01000048_gene6883	3.69e-67	216.0	COG1960@1|root,COG1960@2|Bacteria,1N05C@1224|Proteobacteria,2TT9T@28211|Alphaproteobacteria,3JTG7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	acyl-CoA dehydrogenase	MA20_06725	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_N
k59_946107_1	1479237.JMLY01000001_gene2378	1.87e-08	57.4	28I45@1|root,2Z87Q@2|Bacteria,1R432@1224|Proteobacteria,1S0XF@1236|Gammaproteobacteria,46B9X@72275|Alteromonadaceae	1236|Gammaproteobacteria	H	NHase catalyzes the hydration of various nitrile compounds to the corresponding amides	-	-	4.2.1.84	ko:K20807	ko00364,ko00380,ko00627,ko00643,ko01120,map00364,map00380,map00627,map00643,map01120	-	R04020,R05379,R05596,R07780,R07854	RC00483,RC01345,RC01432	ko00000,ko00001,ko01000	-	-	-	NHase_beta
k59_15924_2	671143.DAMO_2917	2.52e-49	174.0	COG0667@1|root,COG1331@1|root,COG0667@2|Bacteria,COG1331@2|Bacteria,2NP26@2323|unclassified Bacteria	2|Bacteria	O	Protein of unknown function, DUF255	yyaL	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,GlcNAc_2-epim,Thioredox_DsbH
k59_238363_2	661478.OP10G_0618	4.71e-23	99.4	COG2242@1|root,COG2242@2|Bacteria	2|Bacteria	H	protein methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
k59_1405762_1	1163409.UUA_07884	8.2e-07	57.4	COG1629@1|root,COG4771@2|Bacteria,1N6JG@1224|Proteobacteria,1RP10@1236|Gammaproteobacteria,1X3ZY@135614|Xanthomonadales	135614|Xanthomonadales	P	Oar protein	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
k59_1516730_1	667014.Thein_0593	2.94e-07	54.3	COG0438@1|root,COG0438@2|Bacteria,2GHMH@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1516730_2	309798.COPRO5265_1552	1.24e-31	122.0	COG0438@1|root,COG0438@2|Bacteria,1TS4X@1239|Firmicutes,24BYU@186801|Clostridia,42F0Q@68295|Thermoanaerobacterales	186801|Clostridia	M	Glycosyl transferases group 1	-	-	2.4.1.245	ko:K13057	ko00500,ko01100,map00500,map01100	-	R08946,R10525,R11306	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000	-	GT4	-	Glycos_transf_1
k59_15954_1	264732.Moth_1608	1.19e-17	85.5	COG0741@1|root,COG0741@2|Bacteria,1V6DD@1239|Firmicutes,24JDA@186801|Clostridia,42GU3@68295|Thermoanaerobacterales	186801|Clostridia	M	PFAM Lytic transglycosylase catalytic	yjbJ	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT
k59_1128356_1	1121028.ARQE01000008_gene2263	3.49e-15	79.3	COG1879@1|root,COG1879@2|Bacteria,1MWGU@1224|Proteobacteria,2U2E3@28211|Alphaproteobacteria,2PM4I@255475|Aurantimonadaceae	28211|Alphaproteobacteria	G	Periplasmic binding proteins and sugar binding domain of LacI family	-	-	-	ko:K10439,ko:K17205,ko:K17213	ko02010,ko02030,map02010,map02030	M00212,M00591,M00593	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.15,3.A.1.2.19	-	-	Peripla_BP_4
k59_571271_1	1117647.M5M_07370	6.83e-70	226.0	COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,1RMR2@1236|Gammaproteobacteria,1J55X@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_571271_2	1410676.JNKL01000008_gene40	0.000924	40.8	COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,1RM8I@1236|Gammaproteobacteria,1Y3WB@135624|Aeromonadales	135624|Aeromonadales	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
k59_15967_2	1506994.JNLQ01000002_gene3343	7.77e-29	110.0	COG0708@1|root,COG0708@2|Bacteria,1TPFB@1239|Firmicutes,24849@186801|Clostridia,4BXP7@830|Butyrivibrio	186801|Clostridia	L	Endonuclease/Exonuclease/phosphatase family	xth	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
k59_348865_1	717605.Theco_0419	6.93e-45	157.0	COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,4HBB9@91061|Bacilli,26Q9W@186822|Paenibacillaceae	91061|Bacilli	EP	ABC transporter permease	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
k59_1128403_1	1279015.KB908457_gene2311	9.69e-102	305.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,1RP3G@1236|Gammaproteobacteria,1Y56W@135624|Aeromonadales	135624|Aeromonadales	C	COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit	-	-	1.2.4.1,1.2.4.4	ko:K00162,ko:K00167	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
k59_1683541_1	251221.35211835	3.74e-15	80.5	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_849113_1	864051.BurJ1DRAFT_1462	6.83e-74	234.0	COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,2VHXR@28216|Betaproteobacteria,1KK3W@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	4.2.3.152,4.2.3.4	ko:K01735,ko:K19969	ko00400,ko00525,ko01100,ko01110,ko01130,ko01230,map00400,map00525,map01100,map01110,map01130,map01230	M00022,M00814,M00815	R03083,R10937	RC00847,RC03308	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
k59_16011_1	935557.ATYB01000009_gene734	2.49e-29	122.0	COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,4BBZJ@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_7,PAS_9
k59_1016915_1	1537994.JQFW01000021_gene1153	7.49e-38	142.0	COG3547@1|root,COG3547@2|Bacteria	2|Bacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_348880_1	518766.Rmar_2790	2.72e-39	144.0	COG2303@1|root,COG2303@2|Bacteria,4NEHP@976|Bacteroidetes,1FKEH@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	C	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2,GMC_oxred_C,GMC_oxred_N
k59_348880_2	309807.SRU_2528	8.9e-19	85.5	2CISN@1|root,2Z7MB@2|Bacteria,4NFJX@976|Bacteroidetes,1FJQ0@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Gluconate 2-dehydrogenase subunit 3	-	-	-	-	-	-	-	-	-	-	-	-	Gluconate_2-dh3
k59_738900_1	1042376.AFPK01000044_gene2623	4.58e-05	45.1	COG2318@1|root,COG2318@2|Bacteria,4NNQI@976|Bacteroidetes,1I28A@117743|Flavobacteriia,406DE@61432|unclassified Flavobacteriaceae	976|Bacteroidetes	S	DinB superfamily	yfiT	-	-	-	-	-	-	-	-	-	-	-	DinB_2
k59_1240312_1	266117.Rxyl_2809	1.19e-32	122.0	COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria,4CRNI@84995|Rubrobacteria	84995|Rubrobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_571344_1	1089550.ATTH01000001_gene934	1.03e-23	103.0	COG0750@1|root,COG0750@2|Bacteria,4NEAR@976|Bacteroidetes,1FIJ2@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	M	Peptidase family M50	rseP	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
k59_1072009_1	1449069.JMLO01000016_gene3394	1.42e-35	127.0	COG0748@1|root,COG0748@2|Bacteria,2IFYD@201174|Actinobacteria,4G9EE@85025|Nocardiaceae	201174|Actinobacteria	P	F420H(2)-dependent quinone reductase	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
k59_1683573_1	761193.Runsl_1399	6.39e-142	417.0	COG3664@1|root,COG3664@2|Bacteria,4NHQ0@976|Bacteroidetes,47N7Z@768503|Cytophagia	976|Bacteroidetes	G	PFAM glycoside hydrolase family 39	-	-	3.2.1.37	ko:K01198	ko00520,ko01100,map00520,map01100	-	R01433	RC00467	ko00000,ko00001,ko01000	-	GH43	-	Glyco_hydro_39
k59_1294233_1	237368.SCABRO_01504	1.88e-36	137.0	COG0659@1|root,COG0659@2|Bacteria,2IX8K@203682|Planctomycetes	203682|Planctomycetes	P	secondary active sulfate transmembrane transporter activity	-	-	-	ko:K06901	-	-	-	-	ko00000,ko02000	2.A.1.40	-	-	-
k59_738915_1	107636.JQNK01000009_gene3513	4.08e-249	696.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2TRXG@28211|Alphaproteobacteria,370BU@31993|Methylocystaceae	28211|Alphaproteobacteria	L	Transposase DDE domain	-	-	-	ko:K07487	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_1461616_2	1040989.AWZU01000121_gene3966	5.09e-16	72.4	COG1942@1|root,COG1942@2|Bacteria,1Q0HZ@1224|Proteobacteria,2V2E0@28211|Alphaproteobacteria,3K223@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Tautomerase enzyme	-	-	5.3.2.6	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	M00569	R03966,R05389	RC01040,RC01355	ko00000,ko00001,ko00002,ko01000	-	-	-	Tautomerase
k59_626883_1	530564.Psta_0844	4e-09	57.0	COG1778@1|root,COG1778@2|Bacteria,2IZM6@203682|Planctomycetes	203682|Planctomycetes	S	TIGRFAM 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family	-	-	3.1.3.45	ko:K03270	ko00540,ko01100,map00540,map01100	M00063	R03350	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase_3
k59_626883_2	584708.Apau_0901	6.79e-22	94.0	COG2877@1|root,COG2877@2|Bacteria,3T9Z1@508458|Synergistetes	508458|Synergistetes	H	3-deoxy-D-manno-octulosonic acid 8-phosphate synthase	kdsA	-	2.5.1.55	ko:K01627	ko00540,ko01100,map00540,map01100	M00063	R03254	RC00435	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	DAHP_synth_1
k59_683740_1	1121912.AUHD01000035_gene1852	2.23e-23	90.9	2B9ZZ@1|root,323DM@2|Bacteria,4NTEB@976|Bacteroidetes,1I2YU@117743|Flavobacteriia	976|Bacteroidetes	S	COG NOG15344 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_72800_1	1203606.HMPREF1526_01438	1.01e-61	198.0	COG0052@1|root,COG0052@2|Bacteria,1TPNA@1239|Firmicutes,247ZR@186801|Clostridia,36DHW@31979|Clostridiaceae	186801|Clostridia	J	Belongs to the universal ribosomal protein uS2 family	rpsB	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
k59_462921_1	364733.XP_007787955.1	2.82e-06	51.2	COG0412@1|root,2RYJ9@2759|Eukaryota,38F6H@33154|Opisthokonta,3P0P6@4751|Fungi,3QQAC@4890|Ascomycota,20D2G@147545|Eurotiomycetes,3MQC1@451870|Chaetothyriomycetidae	4751|Fungi	Q	dienelactone hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL,SnoaL_2
k59_1518252_1	243159.AFE_0602	1.97e-05	51.6	COG0803@1|root,COG0803@2|Bacteria,1PNWI@1224|Proteobacteria,1RS9D@1236|Gammaproteobacteria,2NBTE@225057|Acidithiobacillales	225057|Acidithiobacillales	P	Zinc-uptake complex component A periplasmic	-	-	-	ko:K02077	-	M00244	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ZnuA
k59_517830_1	189753.AXAS01000055_gene5701	5.85e-77	234.0	COG1765@1|root,COG1765@2|Bacteria,1RBJN@1224|Proteobacteria,2VF54@28211|Alphaproteobacteria,3K6E6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
k59_517830_2	1038866.KB902806_gene2451	8.18e-36	132.0	COG2072@1|root,COG2072@2|Bacteria,1MWPJ@1224|Proteobacteria,2TSQA@28211|Alphaproteobacteria,3JT1R@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	ko:K07222	-	-	-	-	ko00000	-	-	-	Pyr_redox_3
k59_962631_2	575540.Isop_0901	4.74e-14	75.5	COG1082@1|root,COG1716@1|root,COG2199@1|root,COG1082@2|Bacteria,COG1716@2|Bacteria,COG3706@2|Bacteria,2IXZ6@203682|Planctomycetes	203682|Planctomycetes	G	isomerase	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
k59_628281_1	1033806.HTIA_2395	1.16e-18	88.2	COG0565@1|root,arCOG01018@2157|Archaea,2XUIY@28890|Euryarchaeota,23SSK@183963|Halobacteria	183963|Halobacteria	J	RNA methyltransferase, TrmH family, group 1	trmH	-	-	-	-	-	-	-	-	-	-	-	SpoU_methylase
k59_962640_1	380358.XALC_0689	6.39e-18	83.6	COG4301@1|root,COG4301@2|Bacteria,1MUCG@1224|Proteobacteria,1RR44@1236|Gammaproteobacteria,1X4P9@135614|Xanthomonadales	135614|Xanthomonadales	S	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_33
k59_1685240_1	311402.Avi_5351	4.38e-15	75.5	COG1173@1|root,COG1173@2|Bacteria,1MUG0@1224|Proteobacteria,2VETJ@28211|Alphaproteobacteria,4B73C@82115|Rhizobiaceae	28211|Alphaproteobacteria	EP	ABC-type dipeptide oligopeptide nickel transport systems, permease components	dppC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02034,ko:K12370	ko02010,ko02024,map02010,map02024	M00239,M00324	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
k59_1685240_2	765420.OSCT_0206	3.57e-49	167.0	COG0601@1|root,COG0601@2|Bacteria,2G6BV@200795|Chloroflexi,376PM@32061|Chloroflexia	32061|Chloroflexia	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_740427_1	1220582.RRU01S_01_00210	1.62e-74	240.0	COG1070@1|root,COG1070@2|Bacteria,1MW4A@1224|Proteobacteria,2TR7P@28211|Alphaproteobacteria,4BCCU@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	FGGY family of carbohydrate kinases, C-terminal domain	xylBch	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
k59_628296_1	571166.KI421509_gene4104	7.5e-80	251.0	COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,2U4XB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	MgtE intracellular N domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,MgtE,MgtE_N
k59_1073421_1	404589.Anae109_4242	1.28e-54	190.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,43BKG@68525|delta/epsilon subdivisions,2X6YU@28221|Deltaproteobacteria,2YYW6@29|Myxococcales	28221|Deltaproteobacteria	K	ATPase associated with various cellular activities, AAA_5	-	-	-	ko:K02584	ko02020,map02020	-	-	-	ko00000,ko00001,ko03000	-	-	-	GAF,GAF_2,HTH_8,PAS_9,Sigma54_activat
k59_1295826_1	323850.Shew_0927	3.65e-90	281.0	COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,1RNB7@1236|Gammaproteobacteria,2Q9PB@267890|Shewanellaceae	1236|Gammaproteobacteria	S	PFAM Amidohydrolase 3	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_1463040_1	1122176.KB903554_gene3791	1.26e-12	73.9	COG0457@1|root,COG0457@2|Bacteria,4NKQV@976|Bacteroidetes	976|Bacteroidetes	T	Pfam Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1463041_1	644548.SCNU_17435	4.33e-14	69.7	COG1051@1|root,COG1051@2|Bacteria,2IQEU@201174|Actinobacteria,4GEZ3@85026|Gordoniaceae	201174|Actinobacteria	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
k59_1463041_2	1313172.YM304_17230	5.85e-30	117.0	COG0624@1|root,COG0624@2|Bacteria,2GKKW@201174|Actinobacteria,4CP4J@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
k59_572750_1	1158292.JPOE01000002_gene1600	3.57e-91	276.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2VH7B@28216|Betaproteobacteria,1KJBI@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysM	GO:0000003,GO:0000096,GO:0000097,GO:0000902,GO:0000904,GO:0003006,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005773,GO:0005774,GO:0005777,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0007568,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009507,GO:0009532,GO:0009536,GO:0009566,GO:0009567,GO:0009570,GO:0009653,GO:0009826,GO:0009856,GO:0009860,GO:0009932,GO:0009987,GO:0010035,GO:0010038,GO:0016020,GO:0016043,GO:0016049,GO:0016053,GO:0016740,GO:0016765,GO:0019344,GO:0019752,GO:0019842,GO:0019953,GO:0022414,GO:0030154,GO:0030170,GO:0031090,GO:0032501,GO:0032502,GO:0032989,GO:0036094,GO:0040007,GO:0042221,GO:0042579,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0044706,GO:0046394,GO:0046686,GO:0048037,GO:0048046,GO:0048468,GO:0048588,GO:0048589,GO:0048856,GO:0048868,GO:0048869,GO:0050662,GO:0050896,GO:0051704,GO:0060560,GO:0070279,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0098588,GO:0098805,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.47	ko:K12339	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03132,R03601,R04859	RC00020,RC02814,RC02821,RC02876	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_1685271_1	671143.DAMO_2624	1.46e-114	354.0	COG0466@1|root,COG0466@2|Bacteria,2NNNN@2323|unclassified Bacteria	2|Bacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_295456_1	504472.Slin_2519	1.81e-27	112.0	COG3386@1|root,COG3386@2|Bacteria,4NS13@976|Bacteroidetes,47UF3@768503|Cytophagia	976|Bacteroidetes	G	SMP-30/Gluconolaconase/LRE-like region	-	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	SGL
k59_295456_2	679926.Mpet_2761	1.98e-08	56.2	COG3548@1|root,arCOG04887@2157|Archaea,2XUMU@28890|Euryarchaeota	28890|Euryarchaeota	S	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1211
k59_1295860_1	29581.BW37_00870	7.71e-38	148.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,1MX41@1224|Proteobacteria,2WBDI@28216|Betaproteobacteria,475K6@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Tricorn protease homolog	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
k59_1685289_1	1459636.NTE_02033	6.37e-71	222.0	COG0074@1|root,arCOG01339@2157|Archaea,41SEU@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
k59_239962_1	290397.Adeh_2256	9.32e-41	147.0	COG0644@1|root,COG0644@2|Bacteria	2|Bacteria	C	geranylgeranyl reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
k59_72888_1	945713.IALB_1882	6.6e-44	156.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PA,PD40,PDZ_2,Peptidase_M28
k59_127788_1	765420.OSCT_0452	6.25e-39	150.0	COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,2G699@200795|Chloroflexi,3766E@32061|Chloroflexia	32061|Chloroflexia	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Guanylate_cyc,TPR_12
k59_406719_1	1122247.C731_4292	1.46e-44	157.0	COG1028@1|root,COG1028@2|Bacteria,2I9FM@201174|Actinobacteria,234G0@1762|Mycobacteriaceae	201174|Actinobacteria	IQ	Dehydrogenase	fabG3_1	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_796038_1	1122605.KB893626_gene2749	1.39e-14	76.6	COG3757@1|root,COG3757@2|Bacteria,4NKHF@976|Bacteroidetes,1ISMY@117747|Sphingobacteriia	976|Bacteroidetes	M	PFAM Glycosyl hydrolases family 25	acm	-	-	ko:K07273	-	-	-	-	ko00000	-	-	-	Glyco_hydro_25
k59_1130016_1	1047013.AQSP01000119_gene1307	1.07e-102	312.0	COG2403@1|root,COG2403@2|Bacteria,2NNTB@2323|unclassified Bacteria	2|Bacteria	S	cyclic 2,3-diphosphoglycerate synthetase activity	cpgS	-	-	ko:K05716	-	-	R03298	RC00900	ko00000,ko01000	-	-	-	cobW
k59_796048_1	96561.Dole_1777	1.82e-46	164.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2MPSH@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Sigma-54 interaction domain	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_740496_1	452662.SJA_C1-07790	1.03e-20	91.3	COG0500@1|root,COG2226@2|Bacteria,1PVPS@1224|Proteobacteria,2TREE@28211|Alphaproteobacteria,2JZZE@204457|Sphingomonadales	204457|Sphingomonadales	Q	ubiquinone menaquinone biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31
k59_796064_1	1274.HX89_00770	1.88e-12	72.4	COG0515@1|root,COG0515@2|Bacteria,2GJ1J@201174|Actinobacteria,1ZVV9@145357|Dermacoccaceae	201174|Actinobacteria	KLT	Protein kinase domain	pknB	GO:0000270,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008047,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0010698,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0022603,GO:0022604,GO:0030145,GO:0030203,GO:0030234,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032091,GO:0034645,GO:0036211,GO:0040007,GO:0042304,GO:0042546,GO:0042802,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043388,GO:0043393,GO:0043412,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046872,GO:0046890,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051055,GO:0051098,GO:0051099,GO:0051100,GO:0051101,GO:0051128,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0075136,GO:0080090,GO:0098772,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
k59_685327_1	558169.AGAV01000015_gene505	2.56e-93	290.0	COG3876@1|root,COG3876@2|Bacteria,1VRMG@1239|Firmicutes,4HA8F@91061|Bacilli	91061|Bacilli	G	Protein conserved in bacteria	ybbC	-	-	-	-	-	-	-	-	-	-	-	DUF1343
k59_350436_1	861299.J421_6223	9.47e-74	248.0	COG2091@1|root,COG2091@2|Bacteria,1ZUE3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_796072_1	1122604.JONR01000007_gene2903	8.73e-25	110.0	COG3011@1|root,COG3011@2|Bacteria,1NP8B@1224|Proteobacteria,1RZ0C@1236|Gammaproteobacteria,1X5DK@135614|Xanthomonadales	135614|Xanthomonadales	S	Vitamin K-dependent gamma-carboxylase	-	-	-	-	-	-	-	-	-	-	-	-	DUF393,VKG_Carbox
k59_973297_1	1123263.AUKY01000001_gene131	2.11e-13	68.9	COG1528@1|root,COG1528@2|Bacteria,1V1BJ@1239|Firmicutes,3VQDW@526524|Erysipelotrichia	526524|Erysipelotrichia	P	Iron-storage protein	-	-	-	-	-	-	-	-	-	-	-	-	Ferritin
k59_194000_1	1123368.AUIS01000032_gene1398	4.13e-63	213.0	COG0398@1|root,COG1502@1|root,COG0398@2|Bacteria,COG1502@2|Bacteria,1MV8I@1224|Proteobacteria,1RSB6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Pfam SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	PLDc,PLDc_2,SNARE_assoc
k59_1252267_1	985054.JQEZ01000004_gene806	7.33e-17	82.0	28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria,4ND0W@97050|Ruegeria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
k59_194002_1	251221.35211322	7.64e-58	202.0	COG2866@1|root,COG2866@2|Bacteria	2|Bacteria	E	metallocarboxypeptidase activity	-	-	-	ko:K14054	-	-	-	-	ko00000	-	-	-	AstE_AspA,Peptidase_M14
k59_1195094_1	1267535.KB906767_gene5138	1.76e-85	261.0	COG2813@1|root,COG2813@2|Bacteria	2|Bacteria	J	rRNA (guanine-N2-)-methyltransferase activity	-	GO:0003674,GO:0003824,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0009058,GO:0009987,GO:0015994,GO:0015995,GO:0016740,GO:0016741,GO:0018130,GO:0019438,GO:0030493,GO:0030494,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0036067,GO:0036069,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.1.304,2.1.1.333	ko:K13604,ko:K21460	ko00860,ko01110,map00860,map01110	-	R09063	RC00003,RC01662	ko00000,ko00001,ko01000	-	-	-	Dimerisation2,Methyltransf_12,Methyltransf_2,Methyltransf_25
k59_973306_1	1160718.SU9_13950	1.38e-90	278.0	COG1131@1|root,COG1131@2|Bacteria,2GKWB@201174|Actinobacteria	201174|Actinobacteria	V	abc transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_27562_1	1100721.ALKO01000022_gene1904	2.28e-13	75.5	COG4963@1|root,COG4963@2|Bacteria,1MWNY@1224|Proteobacteria,2VNYQ@28216|Betaproteobacteria,4ADIP@80864|Comamonadaceae	28216|Betaproteobacteria	D	AAA domain	cpaE1	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	AAA_31,Response_reg
k59_918774_1	945713.IALB_2868	5.53e-96	294.0	COG2986@1|root,COG2986@2|Bacteria	2|Bacteria	E	ammonia-lyase activity	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
k59_416636_1	794903.OPIT5_01165	1.89e-08	61.6	COG1305@1|root,COG1305@2|Bacteria,46U50@74201|Verrucomicrobia,3K7ZV@414999|Opitutae	414999|Opitutae	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,Transglut_core
k59_1473430_1	926569.ANT_02800	5.66e-79	244.0	COG1162@1|root,COG1162@2|Bacteria,2G5IS@200795|Chloroflexi	200795|Chloroflexi	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase,RsgA_N
k59_1750104_1	518766.Rmar_1427	9.53e-89	280.0	COG0365@1|root,COG0365@2|Bacteria,4NEAD@976|Bacteroidetes,1FIMS@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	I	AMP-binding enzyme C-terminal domain	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_1528384_1	1205680.CAKO01000004_gene3631	4.51e-69	230.0	COG4231@1|root,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2TSHH@28211|Alphaproteobacteria,2JSZE@204441|Rhodospirillales	204441|Rhodospirillales	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	-	-	-	-	-	-	-	-	-	-	-	-	TPP_enzyme_C
k59_582634_1	243090.RB13273	4.8e-50	170.0	COG4307@1|root,COG4307@2|Bacteria	2|Bacteria	T	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_Mx,zinc-ribbon_6
k59_83145_1	861299.J421_2764	2.8e-81	246.0	COG0081@1|root,COG0081@2|Bacteria,1ZSS7@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
k59_83145_2	929506.CbC4_0216	1.12e-21	88.2	COG0080@1|root,COG0080@2|Bacteria,1V1BS@1239|Firmicutes,24FSQ@186801|Clostridia,36I00@31979|Clostridiaceae	186801|Clostridia	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	-	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
k59_527898_1	456442.Mboo_1810	1.4e-40	150.0	arCOG06712@1|root,arCOG07605@1|root,arCOG06712@2157|Archaea,arCOG07605@2157|Archaea,2Y7KG@28890|Euryarchaeota	28890|Euryarchaeota	T	signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GAF_3,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9
k59_1195142_1	1037409.BJ6T_49110	2.38e-41	146.0	COG2301@1|root,COG2301@2|Bacteria,1MW0A@1224|Proteobacteria,2U6H0@28211|Alphaproteobacteria,3K62H@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	HpcH/HpaI aldolase/citrate lyase family	-	-	4.1.3.34	ko:K01644	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
k59_416675_1	765913.ThidrDRAFT_2239	2.84e-25	109.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1T423@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	signal transduction Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
k59_1195150_1	311424.DhcVS_930	4.23e-30	119.0	COG1173@1|root,COG1173@2|Bacteria,2G9WH@200795|Chloroflexi,34DKE@301297|Dehalococcoidia	301297|Dehalococcoidia	EP	N-terminal TM domain of oligopeptide transport permease C	-	-	-	ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1,OppC_N
k59_1750145_1	420662.Mpe_A3153	1.02e-52	167.0	COG0316@1|root,COG0316@2|Bacteria,1RHCW@1224|Proteobacteria,2VR2M@28216|Betaproteobacteria,1KKSP@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Required for insertion of 4Fe-4S clusters	erpA	-	-	ko:K15724	-	-	-	-	ko00000	-	-	-	Fe-S_biosyn
k59_1750145_2	1268622.AVS7_00110	5.56e-20	85.1	COG1664@1|root,COG1664@2|Bacteria,1MZN0@1224|Proteobacteria,2VTZQ@28216|Betaproteobacteria,4AEHA@80864|Comamonadaceae	28216|Betaproteobacteria	M	Integral membrane protein CcmA involved in cell shape determination	ccmA	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
k59_1195152_1	1122613.ATUP01000001_gene1917	7.98e-29	118.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,2TRKI@28211|Alphaproteobacteria,43WEC@69657|Hyphomonadaceae	28211|Alphaproteobacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_83164_1	1379698.RBG1_1C00001G1667	3.78e-48	167.0	COG0577@1|root,COG0577@2|Bacteria,2NQPT@2323|unclassified Bacteria	2|Bacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_1696153_2	97139.C824_05071	1.84e-07	55.5	COG1475@1|root,COG1475@2|Bacteria,1TQ2B@1239|Firmicutes,249VV@186801|Clostridia,36DTS@31979|Clostridiaceae	186801|Clostridia	K	Belongs to the ParB family	spo0J	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
k59_1306736_1	926569.ANT_13990	8.51e-79	244.0	COG0524@1|root,COG0524@2|Bacteria,2G6PQ@200795|Chloroflexi	200795|Chloroflexi	G	PFAM PfkB domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
k59_138144_1	269799.Gmet_0208	7.08e-59	195.0	2C19K@1|root,33PMS@2|Bacteria,1NSP6@1224|Proteobacteria,42YKB@68525|delta/epsilon subdivisions,2WTSZ@28221|Deltaproteobacteria,43TR8@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1140158_1	1347369.CCAD010000090_gene1990	8.17e-48	167.0	COG0504@1|root,COG0504@2|Bacteria,1TP34@1239|Firmicutes,4H9X6@91061|Bacilli,1ZB0S@1386|Bacillus	91061|Bacilli	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
k59_1140158_2	909663.KI867150_gene1177	3.55e-05	47.4	COG1212@1|root,COG1212@2|Bacteria,1MUUU@1224|Proteobacteria,42PTX@68525|delta/epsilon subdivisions,2WMQW@28221|Deltaproteobacteria,2MQEA@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria	kdsB	-	2.7.7.38	ko:K00979	ko00540,ko01100,map00540,map01100	M00063	R03351,R11396	RC00152,RC00910	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_3
k59_1084027_2	671143.DAMO_2269	1.73e-80	243.0	COG2353@1|root,COG2353@2|Bacteria,2NPJW@2323|unclassified Bacteria	2|Bacteria	S	YceI-like domain	-	-	-	-	-	-	-	-	-	-	-	-	YceI
k59_194124_1	1137268.AZXF01000008_gene2171	1.13e-29	114.0	COG0860@1|root,COG0860@2|Bacteria,2GPA9@201174|Actinobacteria,4EM6I@85012|Streptosporangiales	201174|Actinobacteria	M	Ami_3	-	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008745,GO:0016787,GO:0016810,GO:0016811,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464,GO:0061783	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3
k59_194124_2	126957.SMAR011641-PA	1.08e-05	48.5	COG2114@1|root,KOG3619@2759|Eukaryota,38CKV@33154|Opisthokonta,3B9YI@33208|Metazoa,3CRAW@33213|Bilateria,41WAE@6656|Arthropoda	33208|Metazoa	C	Belongs to the adenylyl cyclase class-4 guanylyl cyclase family	ADCY5	GO:0000149,GO:0001101,GO:0001973,GO:0002791,GO:0003008,GO:0003013,GO:0003014,GO:0003018,GO:0003091,GO:0003674,GO:0003824,GO:0004016,GO:0004383,GO:0005080,GO:0005102,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005768,GO:0005829,GO:0005856,GO:0005886,GO:0005902,GO:0005929,GO:0006139,GO:0006163,GO:0006164,GO:0006171,GO:0006182,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006873,GO:0006874,GO:0006875,GO:0007154,GO:0007165,GO:0007166,GO:0007186,GO:0007187,GO:0007188,GO:0007189,GO:0007191,GO:0007193,GO:0007195,GO:0007204,GO:0007212,GO:0007275,GO:0007399,GO:0007417,GO:0007420,GO:0007507,GO:0007568,GO:0007610,GO:0007623,GO:0007626,GO:0008015,GO:0008074,GO:0008104,GO:0008150,GO:0008152,GO:0008179,GO:0008294,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009187,GO:0009190,GO:0009259,GO:0009260,GO:0009410,GO:0009719,GO:0009725,GO:0009975,GO:0009987,GO:0010033,GO:0010243,GO:0010646,GO:0010720,GO:0010721,GO:0010817,GO:0010975,GO:0010977,GO:0012505,GO:0014070,GO:0014072,GO:0016020,GO:0016021,GO:0016829,GO:0016849,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019725,GO:0019899,GO:0019900,GO:0019901,GO:0019932,GO:0019933,GO:0019935,GO:0022008,GO:0023051,GO:0023052,GO:0030003,GO:0030104,GO:0030154,GO:0031224,GO:0031226,GO:0031253,GO:0031344,GO:0031345,GO:0031410,GO:0031528,GO:0031982,GO:0032501,GO:0032502,GO:0032507,GO:0032870,GO:0032879,GO:0032880,GO:0032991,GO:0033036,GO:0033762,GO:0033993,GO:0034613,GO:0034641,GO:0034654,GO:0034694,GO:0034695,GO:0035150,GO:0035296,GO:0035556,GO:0035587,GO:0035588,GO:0035690,GO:0035809,GO:0035811,GO:0042221,GO:0042493,GO:0042592,GO:0042995,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043232,GO:0043278,GO:0043279,GO:0043434,GO:0043900,GO:0043902,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044444,GO:0044445,GO:0044459,GO:0044463,GO:0044464,GO:0045111,GO:0045121,GO:0045185,GO:0045595,GO:0045596,GO:0045597,GO:0045664,GO:0045665,GO:0046058,GO:0046068,GO:0046390,GO:0046483,GO:0046677,GO:0046883,GO:0046982,GO:0046983,GO:0048511,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048699,GO:0048731,GO:0048856,GO:0048869,GO:0048871,GO:0048878,GO:0050708,GO:0050767,GO:0050768,GO:0050789,GO:0050793,GO:0050794,GO:0050796,GO:0050801,GO:0050877,GO:0050878,GO:0050880,GO:0050885,GO:0050891,GO:0050896,GO:0050905,GO:0051046,GO:0051049,GO:0051093,GO:0051094,GO:0051128,GO:0051129,GO:0051179,GO:0051223,GO:0051235,GO:0051239,GO:0051240,GO:0051241,GO:0051480,GO:0051641,GO:0051651,GO:0051716,GO:0051960,GO:0051961,GO:0052652,GO:0055065,GO:0055074,GO:0055080,GO:0055082,GO:0055086,GO:0060281,GO:0060282,GO:0060284,GO:0060322,GO:0060341,GO:0060359,GO:0061178,GO:0061478,GO:0065007,GO:0065008,GO:0070201,GO:0070542,GO:0070727,GO:0070887,GO:0071229,GO:0071236,GO:0071310,GO:0071375,GO:0071377,GO:0071379,GO:0071380,GO:0071396,GO:0071398,GO:0071407,GO:0071417,GO:0071495,GO:0071704,GO:0071867,GO:0071868,GO:0071869,GO:0071870,GO:0071944,GO:0072347,GO:0072359,GO:0072503,GO:0072507,GO:0072521,GO:0072522,GO:0072657,GO:0072658,GO:0072659,GO:0072660,GO:0090066,GO:0090087,GO:0090276,GO:0090407,GO:0097110,GO:0097305,GO:0097306,GO:0097708,GO:0097746,GO:0098589,GO:0098590,GO:0098771,GO:0098805,GO:0098857,GO:0098858,GO:0120025,GO:0120035,GO:0120038,GO:1900193,GO:1900195,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901652,GO:1901653,GO:1901654,GO:1901655,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1903429,GO:1903431,GO:1903530,GO:1904116,GO:1904117,GO:1904321,GO:1904322,GO:1905879,GO:1905881,GO:1990778,GO:2000026,GO:2000241,GO:2000243	4.6.1.1	ko:K08045,ko:K08046	ko00230,ko01522,ko04015,ko04022,ko04024,ko04062,ko04072,ko04114,ko04211,ko04213,ko04261,ko04270,ko04371,ko04540,ko04611,ko04713,ko04714,ko04723,ko04724,ko04725,ko04726,ko04727,ko04728,ko04742,ko04750,ko04911,ko04912,ko04913,ko04914,ko04915,ko04916,ko04918,ko04921,ko04923,ko04924,ko04925,ko04926,ko04927,ko04934,ko04961,ko04962,ko04970,ko04971,ko04972,ko04976,ko05012,ko05030,ko05031,ko05032,ko05034,ko05166,ko05200,ko05414,map00230,map01522,map04015,map04022,map04024,map04062,map04072,map04114,map04211,map04213,map04261,map04270,map04371,map04540,map04611,map04713,map04714,map04723,map04724,map04725,map04726,map04727,map04728,map04742,map04750,map04911,map04912,map04913,map04914,map04915,map04916,map04918,map04921,map04923,map04924,map04925,map04926,map04927,map04934,map04961,map04962,map04970,map04971,map04972,map04976,map05012,map05030,map05031,map05032,map05034,map05166,map05200,map05414	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	AC_N,DUF1053,Guanylate_cyc
k59_974932_1	330214.NIDE1184	9.27e-64	206.0	COG2159@1|root,COG2159@2|Bacteria	2|Bacteria	E	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
k59_1751597_2	1229780.BN381_10199	6.8e-22	99.8	COG5617@1|root,COG5617@2|Bacteria,2H32H@201174|Actinobacteria	201174|Actinobacteria	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1031388_1	383372.Rcas_1840	0.000193	44.3	COG0624@1|root,COG0624@2|Bacteria,2G5IT@200795|Chloroflexi,376TA@32061|Chloroflexia	32061|Chloroflexia	E	peptidase dimerisation domain protein	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
k59_1031388_2	926569.ANT_19700	1.38e-50	169.0	COG1238@1|root,COG1238@2|Bacteria,2G932@200795|Chloroflexi	200795|Chloroflexi	S	PFAM SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
k59_1031388_3	6669.EFX68543	0.000332	43.1	COG0652@1|root,KOG0880@2759|Eukaryota,39ZZ0@33154|Opisthokonta,3BQ82@33208|Metazoa,3D73Y@33213|Bilateria,41YMU@6656|Arthropoda	33208|Metazoa	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005788,GO:0006457,GO:0006458,GO:0006464,GO:0006491,GO:0006517,GO:0006726,GO:0006807,GO:0006915,GO:0006950,GO:0007154,GO:0007165,GO:0007602,GO:0007603,GO:0008144,GO:0008150,GO:0008152,GO:0008219,GO:0009058,GO:0009059,GO:0009100,GO:0009314,GO:0009416,GO:0009581,GO:0009582,GO:0009583,GO:0009584,GO:0009605,GO:0009628,GO:0009987,GO:0012501,GO:0012505,GO:0016018,GO:0016020,GO:0016021,GO:0016063,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0023052,GO:0031224,GO:0031410,GO:0031974,GO:0031982,GO:0033218,GO:0033554,GO:0034976,GO:0035556,GO:0036211,GO:0042277,GO:0042440,GO:0042441,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043324,GO:0043412,GO:0043473,GO:0043474,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0046148,GO:0046154,GO:0048066,GO:0048069,GO:0050789,GO:0050794,GO:0050896,GO:0051606,GO:0051716,GO:0065007,GO:0070013,GO:0070059,GO:0071704,GO:0097190,GO:0097193,GO:0097708,GO:0140096,GO:1901135,GO:1901564,GO:1901566,GO:1901576	5.2.1.8	ko:K01802,ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
k59_362137_1	671143.DAMO_2609	6.92e-55	184.0	COG0673@1|root,COG0673@2|Bacteria,2NREF@2323|unclassified Bacteria	2|Bacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_1529888_1	1217658.F987_00335	1.1e-43	146.0	COG1670@1|root,COG1670@2|Bacteria,1REQ5@1224|Proteobacteria,1S6YN@1236|Gammaproteobacteria,3NNR5@468|Moraxellaceae	1236|Gammaproteobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
k59_1308387_1	864051.BurJ1DRAFT_1463	1.96e-104	309.0	COG1099@1|root,COG1099@2|Bacteria,1MY2H@1224|Proteobacteria,2VJVP@28216|Betaproteobacteria	28216|Betaproteobacteria	S	TatD related DNase	-	-	-	ko:K07051	-	-	-	-	ko00000	-	-	-	TatD_DNase
k59_1418655_1	936455.KI421499_gene6278	1.33e-37	143.0	COG0402@1|root,COG0402@2|Bacteria,1R9S5@1224|Proteobacteria,2U10N@28211|Alphaproteobacteria,3JU9Z@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	F	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_1085622_2	1207063.P24_03725	1.3e-23	92.4	COG0640@1|root,COG0640@2|Bacteria,1N10H@1224|Proteobacteria,2UBRH@28211|Alphaproteobacteria,2JU0I@204441|Rhodospirillales	204441|Rhodospirillales	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
k59_639607_1	640081.Dsui_2265	1.41e-39	149.0	COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,2VHCS@28216|Betaproteobacteria,2KUNR@206389|Rhodocyclales	206389|Rhodocyclales	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	-	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP
k59_1751637_1	497964.CfE428DRAFT_3829	1.34e-68	217.0	COG0657@1|root,COG0657@2|Bacteria	2|Bacteria	I	acetylesterase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,F5_F8_type_C,Peptidase_S9
k59_139602_1	1499967.BAYZ01000139_gene143	1e-88	273.0	COG0463@1|root,COG0463@2|Bacteria,2NP2G@2323|unclassified Bacteria	2|Bacteria	M	Glycosyltransferase like family 2	arnC	GO:0000271,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0030258,GO:0030259,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0070085,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
k59_697010_1	192952.MM_0051	3.2e-38	133.0	arCOG07958@1|root,arCOG07958@2157|Archaea	2157|Archaea	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3225,SnoaL_3
k59_1475025_1	452637.Oter_1873	6.8e-11	67.8	COG0577@1|root,COG0577@2|Bacteria	452637.Oter_1873|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_475461_1	172088.AUGA01000001_gene6634	1.33e-16	82.0	COG1028@1|root,COG1028@2|Bacteria,1MWGC@1224|Proteobacteria,2TSNX@28211|Alphaproteobacteria,3JQUD@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	Dehydrogenase	MA20_18560	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_861616_1	926569.ANT_14230	4.66e-79	259.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2G5W2@200795|Chloroflexi	200795|Chloroflexi	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_751701_1	926569.ANT_06600	1.88e-33	132.0	COG2203@1|root,COG5002@1|root,COG2203@2|Bacteria,COG5002@2|Bacteria,2G7NF@200795|Chloroflexi	200795|Chloroflexi	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA
k59_1196767_1	1122921.KB898187_gene4602	5.61e-83	256.0	COG0667@1|root,COG0667@2|Bacteria,1TRS0@1239|Firmicutes,4HBX5@91061|Bacilli,26STF@186822|Paenibacillaceae	91061|Bacilli	C	Voltage-gated potassium channel	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_1196767_2	468059.AUHA01000002_gene268	1.33e-33	126.0	2A6FK@1|root,30V8I@2|Bacteria,4PIJP@976|Bacteroidetes,1ITEW@117747|Sphingobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_195644_2	545696.HOLDEFILI_00405	3.05e-35	125.0	COG0691@1|root,COG0691@2|Bacteria,1V3IJ@1239|Firmicutes,3VQI2@526524|Erysipelotrichia	526524|Erysipelotrichia	O	the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
k59_84683_1	714961.BFZC1_19310	0.000998	45.1	COG0454@1|root,COG1670@1|root,COG0456@2|Bacteria,COG1670@2|Bacteria,1V1EY@1239|Firmicutes,4HGK9@91061|Bacilli,3IW2M@400634|Lysinibacillus	91061|Bacilli	J	GNAT family acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_3
k59_807423_2	1120960.ATXG01000029_gene3170	8.67e-06	47.8	COG0601@1|root,COG0601@2|Bacteria,2GJ2C@201174|Actinobacteria,4FKII@85023|Microbacteriaceae	201174|Actinobacteria	EP	Binding-protein-dependent transport system inner membrane component	dppB	-	-	ko:K02033,ko:K15581	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1
k59_475503_1	263820.PTO1297	2.04e-14	77.4	COG0079@1|root,arCOG04273@2157|Archaea,2XTFZ@28890|Euryarchaeota,242D6@183967|Thermoplasmata	183967|Thermoplasmata	E	Aminotransferase class I and II	-	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_1529962_1	390989.JOEG01000034_gene1647	0.00063	48.5	COG2199@1|root,COG3850@1|root,COG3706@2|Bacteria,COG3850@2|Bacteria,2IA4H@201174|Actinobacteria,4D9U5@85008|Micromonosporales	201174|Actinobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GGDEF,HAMP
k59_807427_2	1042377.AFPJ01000037_gene2834	2.72e-16	76.3	2CHH4@1|root,32SC0@2|Bacteria,1NPE4@1224|Proteobacteria	1224|Proteobacteria	S	Bacterial PH domain	-	-	-	-	-	-	-	-	-	-	-	-	bPH_5
k59_861643_1	103690.17133336	4.56e-59	189.0	COG0097@1|root,COG0097@2|Bacteria,1G4ZT@1117|Cyanobacteria,1HJTG@1161|Nostocales	1117|Cyanobacteria	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rpl6	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
k59_861643_2	97138.C820_00859	4.98e-08	51.6	COG0096@1|root,COG0096@2|Bacteria,1V3KK@1239|Firmicutes,24HCP@186801|Clostridia,36I6W@31979|Clostridiaceae	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	-	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
k59_1253951_1	1379270.AUXF01000006_gene148	1.53e-44	155.0	COG0042@1|root,COG0042@2|Bacteria,1ZSQC@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	-	-	-	-	-	-	-	-	-	-	-	-	Dus
k59_139683_1	1244869.H261_16710	2.77e-08	59.7	COG2199@1|root,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,2TRAF@28211|Alphaproteobacteria,2JV2B@204441|Rhodospirillales	204441|Rhodospirillales	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
k59_529568_1	555779.Dthio_PD3478	3.03e-55	184.0	COG2006@1|root,COG2006@2|Bacteria,1NV7D@1224|Proteobacteria,42ZEV@68525|delta/epsilon subdivisions,2WV1N@28221|Deltaproteobacteria,2M8BU@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
k59_1640180_1	167542.P9515_15151	2e-16	82.4	COG0111@1|root,COG0111@2|Bacteria,1FZZU@1117|Cyanobacteria,1MM6F@1212|Prochloraceae	1117|Cyanobacteria	E	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
k59_1031536_2	1116369.KB890024_gene2200	1.41e-44	149.0	COG2391@1|root,COG2391@2|Bacteria,1MZ3A@1224|Proteobacteria,2UCDT@28211|Alphaproteobacteria,43K1T@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	transporter component	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
k59_307648_1	861299.J421_0897	1.35e-79	253.0	COG0031@1|root,COG0031@2|Bacteria,1ZTA6@142182|Gemmatimonadetes	142182|Gemmatimonadetes	EK	Domain in cystathionine beta-synthase and other proteins.	-	-	4.2.1.22	ko:K01697	ko00260,ko00270,ko01100,ko01130,ko01230,map00260,map00270,map01100,map01130,map01230	M00035,M00338	R00891,R01290,R04942	RC00056,RC00069,RC00256,RC00489,RC01246	ko00000,ko00001,ko00002,ko01000	-	-	-	CBS,PALP
k59_1640188_1	1122176.KB903532_gene2618	1.94e-08	56.6	2DEZ2@1|root,2ZPUS@2|Bacteria	2|Bacteria	S	Transcription factor zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-TFIIB
k59_432261_1	264402.Cagra.0402s0056.1.p	1.37e-45	166.0	COG0147@1|root,KOG1223@2759|Eukaryota,37NZG@33090|Viridiplantae,3G9ZX@35493|Streptophyta,3HWNC@3699|Brassicales	35493|Streptophyta	E	isochorismate synthase	ICS	GO:0002376,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005741,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006766,GO:0006807,GO:0006950,GO:0006952,GO:0006955,GO:0008150,GO:0008152,GO:0008483,GO:0008909,GO:0009058,GO:0009108,GO:0009110,GO:0009266,GO:0009396,GO:0009409,GO:0009507,GO:0009536,GO:0009605,GO:0009607,GO:0009617,GO:0009620,GO:0009627,GO:0009628,GO:0009696,GO:0009697,GO:0009814,GO:0009987,GO:0010118,GO:0010817,GO:0016020,GO:0016053,GO:0016740,GO:0016769,GO:0016853,GO:0016866,GO:0016999,GO:0017000,GO:0017144,GO:0018130,GO:0018958,GO:0019438,GO:0019752,GO:0019867,GO:0031090,GO:0031347,GO:0031348,GO:0031966,GO:0031967,GO:0031968,GO:0031975,GO:0032787,GO:0034641,GO:0042180,GO:0042181,GO:0042372,GO:0042374,GO:0042398,GO:0042445,GO:0042446,GO:0042537,GO:0042558,GO:0042559,GO:0042742,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045087,GO:0046189,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046820,GO:0048519,GO:0048583,GO:0048585,GO:0050486,GO:0050789,GO:0050832,GO:0050896,GO:0051186,GO:0051188,GO:0051704,GO:0051707,GO:0065007,GO:0065008,GO:0071704,GO:0072330,GO:0080134,GO:0098542,GO:0098588,GO:0098805,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663	5.4.4.2	ko:K02552,ko:K15040	ko00130,ko01053,ko01100,ko01110,ko01130,ko04020,ko04022,ko04216,ko04217,ko04218,ko04621,ko04979,ko05012,ko05016,ko05166,map00130,map01053,map01100,map01110,map01130,map04020,map04022,map04216,map04217,map04218,map04621,map04979,map05012,map05016,map05166	M00116	R01717	RC00588	ko00000,ko00001,ko00002,ko01000,ko02000,ko03029	1.B.8.1	-	-	Chorismate_bind,Porin_3
k59_1269143_1	760192.Halhy_2059	1.61e-59	208.0	COG4447@1|root,COG4447@2|Bacteria,4NESU@976|Bacteroidetes,1IW7V@117747|Sphingobacteriia	976|Bacteroidetes	S	Sortilin, neurotensin receptor 3,	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
k59_1712983_1	190650.CC_2539	9.62e-34	130.0	COG3975@1|root,COG3975@2|Bacteria,1MUHZ@1224|Proteobacteria,2U47T@28211|Alphaproteobacteria,2KHKD@204458|Caulobacterales	204458|Caulobacterales	S	M61 glycyl aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M61
k59_598304_1	481448.Minf_1828	3.4e-33	130.0	COG3011@1|root,COG3011@2|Bacteria,46U84@74201|Verrucomicrobia,37G6V@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	S	Lipase maturation factor	-	-	-	-	-	-	-	-	-	-	-	-	LMF1
k59_936021_1	880073.Calab_3757	7.06e-39	135.0	COG0350@1|root,COG0350@2|Bacteria,2NPJ5@2323|unclassified Bacteria	2|Bacteria	L	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	ogt	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1,Methyltransf_1N
k59_990173_2	1254432.SCE1572_36420	1.35e-31	117.0	COG3436@1|root,COG3436@2|Bacteria,1RHDW@1224|Proteobacteria,43BFC@68525|delta/epsilon subdivisions,2X6TQ@28221|Deltaproteobacteria,2Z3CQ@29|Myxococcales	28221|Deltaproteobacteria	L	IS66 Orf2 like protein	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	TnpB_IS66
k59_990184_1	1123234.AUKI01000011_gene1461	4.67e-81	265.0	28I5V@1|root,2Z891@2|Bacteria,4NF4U@976|Bacteroidetes,1HZRH@117743|Flavobacteriia	976|Bacteroidetes	G	Cellulase N-terminal ig-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CelD_N,Glyco_hydro_9
k59_1100297_1	469383.Cwoe_1832	1.39e-28	106.0	COG2151@1|root,COG2151@2|Bacteria,2IKUH@201174|Actinobacteria,4CQHE@84995|Rubrobacteria	84995|Rubrobacteria	S	Iron-sulfur cluster assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
k59_1378553_1	1089550.ATTH01000001_gene495	1.91e-80	258.0	COG0154@1|root,COG0154@2|Bacteria,4NF8C@976|Bacteroidetes,1FIX6@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	J	Amidase	-	-	-	-	-	-	-	-	-	-	-	-	Amidase
k59_1210701_1	1232437.KL661966_gene3173	1.7e-63	215.0	COG2133@1|root,COG2133@2|Bacteria,1NRFC@1224|Proteobacteria,42YAV@68525|delta/epsilon subdivisions,2WTUF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_377102_2	543728.Vapar_4004	1.16e-05	53.1	COG3391@1|root,COG3794@1|root,COG3391@2|Bacteria,COG3794@2|Bacteria,1P862@1224|Proteobacteria,2VM1W@28216|Betaproteobacteria	28216|Betaproteobacteria	C	TIGRFAM 40-residue YVTN family beta-propeller repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
k59_432321_1	530564.Psta_2288	1.48e-66	226.0	COG0841@1|root,COG0841@2|Bacteria,2IX3P@203682|Planctomycetes	203682|Planctomycetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K18299	-	M00641	-	-	ko00000,ko00002,ko01504,ko02000	2.A.6.2.16	-	-	ACR_tran
k59_598359_2	1121028.ARQE01000002_gene1658	9.72e-10	60.8	COG0438@1|root,COG0438@2|Bacteria,1MVEG@1224|Proteobacteria,2U1M8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Domain of unknown function (DUF3492)	-	-	-	ko:K21011	ko02025,map02025	-	-	-	ko00000,ko00001,ko01003	-	GT4	-	DUF3492,Glycos_transf_1
k59_1100347_1	1449351.RISW2_03665	1.61e-43	160.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,2TTPX@28211|Alphaproteobacteria,4KMEG@93682|Roseivivax	28211|Alphaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_652878_1	861299.J421_1854	1.65e-60	200.0	COG4952@1|root,COG4952@2|Bacteria	2|Bacteria	M	isomerase activity	rhaI	-	5.3.1.14	ko:K01820	ko00040,ko00051,ko01120,map00040,map00051,map01120	-	R01906,R02437,R06589	RC00376,RC00434,RC00516	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2,RhaA
k59_1765177_1	1122201.AUAZ01000062_gene175	1.19e-11	60.5	COG3668@1|root,COG3668@2|Bacteria,1N73M@1224|Proteobacteria,1SCB7@1236|Gammaproteobacteria,46BKU@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	PFAM plasmid	-	-	-	-	-	-	-	-	-	-	-	-	ParE_toxin
k59_714771_1	880072.Desac_2183	1.57e-83	259.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,42MKR@68525|delta/epsilon subdivisions,2WJ0U@28221|Deltaproteobacteria,2MQ46@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	PFAM Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
k59_101334_1	349520.PPE_01489	6.66e-19	92.0	COG0609@1|root,COG0609@2|Bacteria,1TPX6@1239|Firmicutes,4HBTA@91061|Bacilli,26RZ1@186822|Paenibacillaceae	91061|Bacilli	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	fhuB5	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
k59_1602702_1	1144312.PMI09_00508	8.42e-56	191.0	COG2072@1|root,COG2072@2|Bacteria,1MWPJ@1224|Proteobacteria,2TSQA@28211|Alphaproteobacteria,4B9Z6@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	L-lysine 6-monooxygenase (NADPH-requiring)	-	-	-	ko:K07222	-	-	-	-	ko00000	-	-	-	Pyr_redox_3
k59_1102642_1	83406.HDN1F_10930	1.33e-55	188.0	28H52@1|root,2Z7HQ@2|Bacteria,1MXTF@1224|Proteobacteria,1RN8H@1236|Gammaproteobacteria,1J8US@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1329)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1329
k59_600469_1	525897.Dbac_0080	9.85e-61	196.0	COG2962@1|root,COG2962@2|Bacteria,1MX5G@1224|Proteobacteria,42QPT@68525|delta/epsilon subdivisions,2WN1M@28221|Deltaproteobacteria,2M987@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	TIGRFAM RarD protein, DMT superfamily transporter	rarD	-	-	ko:K05786	-	-	-	-	ko00000,ko02000	2.A.7.7	-	-	EamA
k59_1102647_1	491952.Mar181_0728	8.33e-26	110.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,1RNAM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	TRAP-type C4-dicarboxylate transport system, large permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_1767873_1	861299.J421_2922	2.91e-10	60.5	COG0568@1|root,COG0568@2|Bacteria,1ZSR6@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_1767873_2	765869.BDW_02895	3.37e-17	80.5	COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,42NJE@68525|delta/epsilon subdivisions,2WKMA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	Belongs to the peptidase S26 family	-	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
k59_1159293_1	349520.PPE_00704	1.37e-18	86.3	COG0350@1|root,COG1600@1|root,COG0350@2|Bacteria,COG1600@2|Bacteria,1TP6Q@1239|Firmicutes,4HAEW@91061|Bacilli,26R4Y@186822|Paenibacillaceae	91061|Bacilli	C	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	queG	GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Fer4_16,HEAT_2
k59_1159293_2	1068980.ARVW01000001_gene6489	7.04e-27	108.0	COG0477@1|root,COG2814@2|Bacteria,2IDPG@201174|Actinobacteria	201174|Actinobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
k59_1213047_1	760192.Halhy_0718	2.39e-106	329.0	COG1529@1|root,COG1529@2|Bacteria,4NFFU@976|Bacteroidetes,1IPWF@117747|Sphingobacteriia	976|Bacteroidetes	C	COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs	-	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C2
k59_379456_1	390989.JOEG01000001_gene5219	4.18e-41	147.0	COG0501@1|root,COG0501@2|Bacteria,2GKJQ@201174|Actinobacteria,4DBRM@85008|Micromonosporales	201174|Actinobacteria	O	Peptidase M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
k59_379456_2	1320556.AVBP01000016_gene2776	2.15e-27	109.0	COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,2TW14@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	COG0626 Cystathionine beta-lyases cystathionine gamma-synthases	metB	-	4.4.1.1	ko:K01758	ko00260,ko00270,ko00450,ko01100,ko01130,ko01230,map00260,map00270,map00450,map01100,map01130,map01230	M00338	R00782,R01001,R02408,R04770,R04930,R09366	RC00056,RC00069,RC00348,RC00382,RC00710,RC01209,RC01210,RC01245,RC02303	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Cys_Met_Meta_PP
k59_1656467_1	1380380.JIAX01000006_gene928	1.96e-88	296.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_823988_1	379066.GAU_0518	2.74e-107	335.0	COG0495@1|root,COG0495@2|Bacteria,1ZSXC@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Leucyl-tRNA synthetase, Domain 2	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
k59_1545220_1	1121957.ATVL01000007_gene2363	1.16e-24	108.0	COG1835@1|root,COG1835@2|Bacteria,4NMNZ@976|Bacteroidetes,47KWV@768503|Cytophagia	976|Bacteroidetes	I	Domain of unknown function (DUF4153)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4153
k59_101394_1	1278309.KB907108_gene1550	3e-43	157.0	COG1538@1|root,COG1538@2|Bacteria,1MWCJ@1224|Proteobacteria,1RQQV@1236|Gammaproteobacteria,1XJ1X@135619|Oceanospirillales	135619|Oceanospirillales	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_44768_1	648996.Theam_0443	2.09e-28	117.0	COG0475@1|root,COG0475@2|Bacteria,2G3ZZ@200783|Aquificae	200783|Aquificae	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
k59_1715164_1	83406.HDN1F_10280	7.68e-86	274.0	COG0128@1|root,COG0287@1|root,COG0128@2|Bacteria,COG0287@2|Bacteria,1MWMK@1224|Proteobacteria,1RQ8U@1236|Gammaproteobacteria,1J541@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	1.3.1.12,1.3.1.43,2.5.1.19	ko:K00210,ko:K00220,ko:K00800	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00022,M00025,M00040	R00732,R01728,R03460	RC00125,RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase,PDH
k59_1767939_1	1449076.JOOE01000001_gene3004	4.21e-35	130.0	2CISN@1|root,2Z7MB@2|Bacteria,1MZKH@1224|Proteobacteria,2UGIZ@28211|Alphaproteobacteria,2K9B2@204457|Sphingomonadales	204457|Sphingomonadales	S	Gluconate 2-dehydrogenase subunit 3	-	-	-	-	-	-	-	-	-	-	-	-	Gluconate_2-dh3
k59_1435608_1	333138.LQ50_14025	8.15e-10	60.8	COG2055@1|root,COG2055@2|Bacteria,1TR0Z@1239|Firmicutes,4HB6X@91061|Bacilli,1ZB9H@1386|Bacillus	91061|Bacilli	C	Belongs to the LDH2 MDH2 oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Ldh_2
k59_1102721_1	314285.KT71_02522	7.74e-69	231.0	COG1913@1|root,COG1913@2|Bacteria,1MY52@1224|Proteobacteria,1RSIP@1236|Gammaproteobacteria,1J4I2@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF5117)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4953,DUF5117
k59_714886_1	1347087.CBYO010000014_gene1965	6.26e-38	146.0	COG0847@1|root,COG1199@1|root,COG0847@2|Bacteria,COG1199@2|Bacteria,1TQHQ@1239|Firmicutes,4HB2Y@91061|Bacilli	91061|Bacilli	L	helicase involved in DNA repair and perhaps also replication	dinG	-	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,Helicase_C_2,RNase_T,ResIII
k59_938460_1	926569.ANT_01220	1.44e-80	257.0	COG1001@1|root,COG1001@2|Bacteria,2G64P@200795|Chloroflexi	200795|Chloroflexi	F	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family	ade	-	3.5.4.2	ko:K01486	ko00230,ko01100,map00230,map01100	-	R01244	RC00477	ko00000,ko00001,ko01000	-	-	-	Adenine_deam_C,Amidohydro_1
k59_434721_1	986075.CathTA2_2989	1.83e-25	107.0	COG0809@1|root,COG0809@2|Bacteria,1TPKD@1239|Firmicutes,4H9PT@91061|Bacilli	91061|Bacilli	J	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
k59_1326319_1	236097.ADG881_2993	1.62e-30	130.0	COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,1MVI9@1224|Proteobacteria,1RNB0@1236|Gammaproteobacteria,1XI0P@135619|Oceanospirillales	135619|Oceanospirillales	D	protein involved in exopolysaccharide biosynthesis	wzc	-	-	ko:K16554,ko:K16692	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01001,ko02000	8.A.3.1	-	-	AAA_31,GNVR,Wzz
k59_1715206_1	477641.MODMU_5367	8.58e-39	149.0	COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria,4ERST@85013|Frankiales	201174|Actinobacteria	C	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_824058_1	671143.DAMO_1588	1.14e-71	237.0	COG1138@1|root,COG1138@2|Bacteria,2NNYV@2323|unclassified Bacteria	2|Bacteria	O	Cytochrome C assembly protein	ccmF	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0017003,GO:0017004,GO:0017006,GO:0018063,GO:0018193,GO:0018198,GO:0018378,GO:0019538,GO:0020037,GO:0022607,GO:0031224,GO:0031226,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046906,GO:0048037,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564	-	ko:K02198,ko:K04016	-	-	R05712	RC00176	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
k59_714914_2	395495.Lcho_0046	4.98e-34	122.0	COG0745@1|root,COG0745@2|Bacteria,1RD7E@1224|Proteobacteria,2VVWD@28216|Betaproteobacteria,1KPCJ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	PFAM response regulator receiver	-	-	-	ko:K11443	ko02020,ko04112,map02020,map04112	M00511	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
k59_1715212_1	391624.OIHEL45_18966	4.93e-86	275.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TRFN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase a b hammerhead	-	-	1.17.1.4	ko:K11177	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_266490_1	1122217.KB899605_gene66	7.3e-61	200.0	COG0138@1|root,COG0138@2|Bacteria,1TPQ5@1239|Firmicutes,4H2SF@909932|Negativicutes	909932|Negativicutes	F	AICARFT IMPCHase bienzyme	purH2	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas
k59_1767996_1	926569.ANT_01110	1.15e-25	108.0	COG0845@1|root,COG0845@2|Bacteria,2G8X1@200795|Chloroflexi	200795|Chloroflexi	M	PFAM secretion protein HlyD family protein	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3
k59_1213150_1	1510531.JQJJ01000015_gene3017	1.11e-13	72.0	COG0053@1|root,COG0053@2|Bacteria,1MVH8@1224|Proteobacteria,2TVQV@28211|Alphaproteobacteria,3JSW2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Cation efflux family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
k59_1159442_1	1123242.JH636434_gene3841	8.38e-70	218.0	COG1484@1|root,COG1484@2|Bacteria,2J3U3@203682|Planctomycetes	203682|Planctomycetes	L	PFAM IstB-like ATP binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
k59_600583_1	1089553.Tph_c21870	9.49e-07	51.6	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
k59_325378_1	1528106.JRJE01000020_gene2455	7.15e-25	105.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,2JPID@204441|Rhodospirillales	204441|Rhodospirillales	T	signal transduction histidine kinase	-	-	2.7.13.3	ko:K13587	ko02020,ko04112,map02020,map04112	M00512	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS_4,PAS_8,PAS_9,Response_reg
k59_1159456_1	379066.GAU_3098	8.01e-05	47.8	COG4249@1|root,COG4249@2|Bacteria,1ZUQX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Peptidase C14 caspase catalytic subunit p20	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1435677_1	1463856.JOHY01000019_gene2637	5.65e-16	74.3	COG1720@1|root,COG1720@2|Bacteria,2IKKT@201174|Actinobacteria	201174|Actinobacteria	S	Uncharacterised protein family UPF0066	-	-	-	-	-	-	-	-	-	-	-	-	UPF0066
k59_1435677_2	1121946.AUAX01000012_gene6528	1.29e-23	96.7	COG1309@1|root,COG1309@2|Bacteria,2IJNE@201174|Actinobacteria,4DDDQ@85008|Micromonosporales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
k59_1326369_1	926569.ANT_05240	3.05e-41	153.0	COG0109@1|root,COG1612@1|root,COG0109@2|Bacteria,COG1612@2|Bacteria,2G5UC@200795|Chloroflexi	200795|Chloroflexi	H	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	COX15-CtaA,UbiA
k59_44860_1	1122963.AUHB01000004_gene3168	2.06e-91	272.0	COG2884@1|root,COG2884@2|Bacteria,1MVQ4@1224|Proteobacteria,2TS9Y@28211|Alphaproteobacteria,36XBI@31993|Methylocystaceae	28211|Alphaproteobacteria	D	AAA domain, putative AbiEii toxin, Type IV TA system	ftsE	-	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
k59_1381082_1	1128421.JAGA01000002_gene1867	1.42e-09	64.3	COG1290@1|root,COG1290@2|Bacteria,2NP8C@2323|unclassified Bacteria	2|Bacteria	C	Cytochrome b(N-terminal)/b6/petB	petB	-	-	-	-	-	-	-	-	-	-	iAF987.Gmet_3585	Cytochrom_B_C,Cytochrom_B_N_2,Cytochrome_B
k59_782715_1	83406.HDN1F_16850	5.9e-107	330.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,1RP3T@1236|Gammaproteobacteria,1J5GE@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	ppsA	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008986,GO:0009058,GO:0009987,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016781,GO:0019318,GO:0019319,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046872,GO:0071704,GO:1901576	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	iEcE24377_1341.EcE24377A_1919,iYL1228.KPN_02160	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_949580_1	1267534.KB906759_gene1728	1.2e-48	172.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,3Y3NX@57723|Acidobacteria,2JKIA@204432|Acidobacteriia	2|Bacteria	C	Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg	porA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iLJ478.TM1164	PFOR_II,POR,POR_N,Transketolase_C
k59_782717_1	1245469.S58_69210	1.01e-60	203.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2TSA7@28211|Alphaproteobacteria,3JTRC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_337766_1	1469245.JFBG01000044_gene1863	3.89e-101	299.0	COG1402@1|root,COG1402@2|Bacteria,1MXR9@1224|Proteobacteria,1RZ21@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Creatinine amidohydrolase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
k59_1450050_1	1198232.CYCME_2226	8.91e-13	66.6	COG2096@1|root,COG2096@2|Bacteria,1RDUF@1224|Proteobacteria,1S40D@1236|Gammaproteobacteria,4628K@72273|Thiotrichales	72273|Thiotrichales	S	Cobalamin adenosyltransferase	-	-	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans
k59_1450050_2	338966.Ppro_2894	6.22e-54	177.0	COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,42MA4@68525|delta/epsilon subdivisions,2WIPU@28221|Deltaproteobacteria,43UK1@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	Enoyl- acyl-carrier-protein reductase NADH	fabI	-	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_337768_1	593907.Celgi_0123	0.000741	44.7	COG1876@1|root,COG1876@2|Bacteria,2ICD5@201174|Actinobacteria,4F1E2@85016|Cellulomonadaceae	201174|Actinobacteria	M	PFAM peptidase M15B and M15C DD-carboxypeptidase VanY endolysin	-	-	-	-	-	-	-	-	-	-	-	-	VanY
k59_115538_1	861299.J421_1696	2.65e-65	223.0	COG2866@1|root,COG2866@2|Bacteria,1ZUNB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Zinc carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
k59_615886_1	1121930.AQXG01000015_gene1861	9.71e-46	166.0	COG4206@1|root,COG4206@2|Bacteria	2|Bacteria	H	cobalamin-transporting ATPase activity	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,CarboxypepD_reg,Plug
k59_504887_1	572478.Vdis_0392	1.98e-21	98.6	COG0674@1|root,arCOG01606@2157|Archaea,2XQ12@28889|Crenarchaeota	28889|Crenarchaeota	C	Pyruvate ferredoxin flavodoxin oxidoreductase	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
k59_337781_1	671143.DAMO_0882	3.4e-38	138.0	COG1028@1|root,COG1028@2|Bacteria,2NQVU@2323|unclassified Bacteria	2|Bacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.5.1.33	ko:K03793	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
k59_1672297_1	1463920.JOGB01000052_gene3901	1.5e-22	104.0	COG0642@1|root,COG2205@2|Bacteria,2GJKC@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	kdpD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0044424,GO:0044464,GO:0071944	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,HATPase_c,HisKA,KdpD,Usp
k59_949606_1	7425.NV15140-PA	1.25e-19	90.5	COG1012@1|root,KOG2450@2759|Eukaryota,38CDB@33154|Opisthokonta,3BCJG@33208|Metazoa,3CU6J@33213|Bilateria,41WX8@6656|Arthropoda,3SKJT@50557|Insecta,46EG8@7399|Hymenoptera	33208|Metazoa	C	Aldehyde dehydrogenase X, mitochondrial-like	-	GO:0003674,GO:0003824,GO:0004029,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006090,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0031974,GO:0032787,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0055114,GO:0070013,GO:0071704	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_949606_2	315730.BcerKBAB4_3177	2.21e-39	147.0	COG0665@1|root,COG0665@2|Bacteria,1TR1R@1239|Firmicutes,4HB8E@91061|Bacilli,1ZC21@1386|Bacillus	91061|Bacilli	E	FAD dependent oxidoreductase	-	-	-	ko:K09471	ko00330,ko01100,map00330,map01100	M00136	R07415	RC00062	ko00000,ko00001,ko00002,ko01000	-	-	-	DAO
k59_117185_1	865937.Gilli_0162	2.46e-07	51.2	COG2120@1|root,COG2120@2|Bacteria,4NE9K@976|Bacteroidetes,1HX7T@117743|Flavobacteriia,2P6FG@244698|Gillisia	976|Bacteroidetes	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
k59_117185_2	379066.GAU_0394	2.67e-129	385.0	COG0591@1|root,COG0591@2|Bacteria,1ZT93@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Sodium:solute symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
k59_951354_1	1282876.BAOK01000002_gene674	6.75e-18	83.6	COG0625@1|root,COG0625@2|Bacteria,1MXJD@1224|Proteobacteria,2U5C5@28211|Alphaproteobacteria,4BR9K@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	O	Glutathione S-transferase, C-terminal domain	-	-	2.5.1.18	ko:K00799,ko:K03599	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000,ko03021	1.A.12.2.2,1.A.12.3.1,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_N_3
k59_673484_1	1198232.CYCME_0602	6.31e-54	173.0	COG0757@1|root,COG0757@2|Bacteria,1RDDT@1224|Proteobacteria,1S3PX@1236|Gammaproteobacteria,460Q7@72273|Thiotrichales	72273|Thiotrichales	E	Catalyzes a trans-dehydration via an enolate intermediate	aroQ	-	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
k59_673484_2	243277.VC_0296	8.41e-12	62.8	COG0511@1|root,COG0511@2|Bacteria,1RCXA@1224|Proteobacteria,1S3YP@1236|Gammaproteobacteria,1XWV0@135623|Vibrionales	135623|Vibrionales	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA	accB	-	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
k59_951372_1	1120956.JHZK01000002_gene946	1.61e-132	383.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2TS33@28211|Alphaproteobacteria,1JNQ8@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	Pyridoxal-phosphate dependent enzyme	cysK	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_451137_2	1123070.KB899254_gene1160	3.21e-19	83.2	COG0645@1|root,COG0645@2|Bacteria,46X6T@74201|Verrucomicrobia,2IUS3@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_33
k59_1507225_1	861299.J421_0118	2.26e-16	83.6	COG3325@1|root,COG3325@2|Bacteria	2|Bacteria	G	chitin binding	-	-	3.2.1.14	ko:K01183	ko00520,ko01100,map00520,map01100	-	R01206,R02334	RC00467	ko00000,ko00001,ko01000	-	GH18	-	Calx-beta,Glyco_hydro_18,PA14,PKD,fn3
k59_617627_1	395493.BegalDRAFT_1734	2.31e-52	179.0	COG0624@1|root,COG0624@2|Bacteria,1MW6G@1224|Proteobacteria,1RMNQ@1236|Gammaproteobacteria,460BJ@72273|Thiotrichales	72273|Thiotrichales	E	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
k59_895938_2	525367.HMPREF0556_12438	2.73e-70	223.0	COG0022@1|root,COG0022@2|Bacteria,1TP3J@1239|Firmicutes,4HAP6@91061|Bacilli,26JP8@186820|Listeriaceae	91061|Bacilli	C	Pyruvate 2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit	bfmBAB	-	1.2.4.4	ko:K00167,ko:K21417	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU24040	Transket_pyr,Transketolase_C
k59_1173643_1	78245.Xaut_3070	2.8e-07	53.9	COG1309@1|root,COG1309@2|Bacteria,1MUUY@1224|Proteobacteria,2TUIH@28211|Alphaproteobacteria,3EYJI@335928|Xanthobacteraceae	28211|Alphaproteobacteria	K	WHG domain	MA20_04045	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
k59_1451921_1	1151292.QEW_0594	1.72e-07	56.6	COG1309@1|root,COG1309@2|Bacteria,1V1M7@1239|Firmicutes,24FRQ@186801|Clostridia	186801|Clostridia	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_395364_1	348824.LPU83_1717	9.57e-10	59.7	28PTM@1|root,2ZCEU@2|Bacteria,1R5DD@1224|Proteobacteria,2TVG7@28211|Alphaproteobacteria,4BGD7@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Family of unknown function (DUF5309)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5309
k59_1618262_1	861299.J421_0334	1.99e-25	109.0	COG0577@1|root,COG0577@2|Bacteria	861299.J421_0334|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_729220_1	1122132.AQYH01000010_gene3950	8.9e-40	151.0	COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,2TR3B@28211|Alphaproteobacteria,4B9QM@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	lptD	-	-	ko:K04744	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA,OstA_C
k59_1396090_1	1487921.DP68_16125	2.61e-20	91.3	COG1301@1|root,COG1301@2|Bacteria,1TPME@1239|Firmicutes,247UX@186801|Clostridia,36DYZ@31979|Clostridiaceae	186801|Clostridia	C	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family	gltT	-	-	ko:K11102	-	-	-	-	ko00000,ko02000	2.A.23.1.1,2.A.23.1.2	-	-	SDF
k59_1451943_1	215803.DB30_7885	2.47e-07	58.2	COG1714@1|root,COG1714@2|Bacteria,1RIE9@1224|Proteobacteria,4315Y@68525|delta/epsilon subdivisions,2WWQ6@28221|Deltaproteobacteria,2YX8X@29|Myxococcales	28221|Deltaproteobacteria	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	RDD
k59_1284905_1	479431.Namu_0806	5.42e-90	283.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4ERP6@85013|Frankiales	201174|Actinobacteria	V	ABC transporter, transmembrane region	yfiC	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_729225_1	56110.Oscil6304_5585	1.26e-40	150.0	COG2837@1|root,COG2837@2|Bacteria	2|Bacteria	P	iron assimilation	-	-	-	ko:K16301	-	-	-	-	ko00000,ko01000,ko02000	2.A.108.2.3	-	-	Dyp_perox
k59_839977_2	555793.WSK_4047	5.67e-08	57.8	28NHI@1|root,2ZBJA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_673554_2	285514.JNWO01000026_gene2446	4.28e-20	90.9	COG4097@1|root,COG4097@2|Bacteria,2GQH2@201174|Actinobacteria	201174|Actinobacteria	P	nitric oxide dioxygenase activity	-	-	-	ko:K17247	-	-	-	-	ko00000	-	-	-	Ferric_reduct
k59_1451949_2	1157708.KB907456_gene2307	1.01e-21	87.0	COG3237@1|root,COG3237@2|Bacteria,1N6X4@1224|Proteobacteria,2VW2V@28216|Betaproteobacteria,4AFCQ@80864|Comamonadaceae	28216|Betaproteobacteria	S	Belongs to the UPF0337 (CsbD) family	-	-	-	-	-	-	-	-	-	-	-	-	CsbD
k59_173010_1	639282.DEFDS_2164	1.34e-06	50.1	COG0701@1|root,COG0701@2|Bacteria,2GGGP@200930|Deferribacteres	200930|Deferribacteres	S	Predicted permease	-	-	-	-	-	-	-	-	-	-	-	-	ArsP_1
k59_173010_2	237368.SCABRO_01059	4.61e-37	130.0	COG1853@1|root,COG1853@2|Bacteria	2|Bacteria	S	FMN binding	flr	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
k59_61871_1	426117.M446_7013	1.43e-30	122.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2TTHU@28211|Alphaproteobacteria,1JWXG@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	HTH_29,rve
k59_284347_1	1041142.ATTP01000013_gene730	5.46e-70	229.0	COG0277@1|root,COG0277@2|Bacteria,1MUPW@1224|Proteobacteria,2TUNK@28211|Alphaproteobacteria,4BCK6@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	Berberine and berberine like	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
k59_561990_1	675635.Psed_0725	1.11e-33	129.0	COG0560@1|root,COG0560@2|Bacteria,2GKRQ@201174|Actinobacteria	201174|Actinobacteria	E	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
k59_395403_1	1294143.H681_04485	4.2e-97	293.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,1RMAQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_784547_1	911045.PSE_0100	2.99e-65	210.0	COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,2TRTJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	cytochrome c peroxidase	ccpA	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
k59_729253_2	388467.A19Y_3152	3.4e-22	95.1	COG0187@1|root,COG0187@2|Bacteria,1G139@1117|Cyanobacteria,1H885@1150|Oscillatoriales	1117|Cyanobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005575,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,HTH_3,Intein_splicing,LAGLIDADG_3,Toprim
k59_1062463_1	1207063.P24_02241	2.34e-73	229.0	COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,2TSM8@28211|Alphaproteobacteria,2JQG4@204441|Rhodospirillales	204441|Rhodospirillales	CH	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	gyaR	-	1.1.1.26	ko:K00015	ko00630,ko01100,ko01110,ko01120,map00630,map01100,map01110,map01120	-	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_1674113_1	342610.Patl_3923	2.77e-26	105.0	COG3764@1|root,COG3764@2|Bacteria,1P806@1224|Proteobacteria,1S9RI@1236|Gammaproteobacteria,2Q36A@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	M	Sortase family	srtA	-	3.4.22.70	ko:K07284	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Sortase
k59_1674113_2	330214.NIDE0941	1.88e-09	62.8	COG2304@1|root,COG2304@2|Bacteria	2|Bacteria	IU	oxidoreductase activity	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VIT,VWA_3
k59_117297_1	1128427.KB904821_gene3906	9.19e-73	240.0	COG0155@1|root,COG0155@2|Bacteria,1G0Z6@1117|Cyanobacteria,1H7MU@1150|Oscillatoriales	1117|Cyanobacteria	C	Nitrite and sulphite reductase 4Fe-4S domain	-	-	1.8.7.1	ko:K00392	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R00859,R03600	RC00065	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
k59_1507318_1	1278309.KB907099_gene2933	3.1e-31	122.0	COG0492@1|root,COG1145@1|root,COG0492@2|Bacteria,COG1145@2|Bacteria,1QYEW@1224|Proteobacteria,1T3PI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	CO	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5,Pyr_redox_3
k59_117306_1	1051632.TPY_1317	8.09e-53	175.0	COG0388@1|root,COG0388@2|Bacteria,1TRMU@1239|Firmicutes,25B19@186801|Clostridia	186801|Clostridia	S	N-carbamoylputrescine amidase	aguB	-	3.5.1.53,3.5.1.6	ko:K01431,ko:K12251	ko00240,ko00330,ko00410,ko00770,ko00983,ko01100,map00240,map00330,map00410,map00770,map00983,map01100	M00046	R00905,R01152,R04666,R08228	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase
k59_173054_1	497964.CfE428DRAFT_5750	5.12e-06	55.5	COG2202@1|root,COG4585@1|root,COG2202@2|Bacteria,COG4585@2|Bacteria,46VC0@74201|Verrucomicrobia	74201|Verrucomicrobia	T	Histidine kinase	moxY	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,PAS,PAS_9
k59_896034_1	313606.M23134_01148	1.25e-53	182.0	2F4SK@1|root,33XF9@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1618337_1	713586.KB900536_gene1736	5.7e-37	140.0	COG2271@1|root,COG2271@2|Bacteria,1QU9E@1224|Proteobacteria,1T2A0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Pfam Major Facilitator Superfamily	-	-	-	ko:K08223	-	-	-	-	ko00000,ko02000	2.A.1.35	-	-	MFS_1
k59_673623_2	1278307.KB907007_gene183	4.41e-21	91.3	COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,1S3WP@1236|Gammaproteobacteria,2QHMK@267894|Psychromonadaceae	1236|Gammaproteobacteria	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism	ssb	GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006281,GO:0006298,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008047,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0030234,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0042802,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050790,GO:0050896,GO:0051716,GO:0065007,GO:0065009,GO:0071496,GO:0071704,GO:0090304,GO:0097159,GO:0098772,GO:1901360,GO:1901363,GO:1901576	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
k59_840042_1	396588.Tgr7_1990	3.43e-62	216.0	COG5001@1|root,COG5002@1|root,COG5001@2|Bacteria,COG5002@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1WVZ7@135613|Chromatiales	135613|Chromatiales	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,HAMP,PAS,PAS_3,PAS_4,Response_reg
k59_117317_1	36809.MAB_0428	5.04e-19	89.0	COG1173@1|root,COG1173@2|Bacteria,2GJ9E@201174|Actinobacteria,233QB@1762|Mycobacteriaceae	201174|Actinobacteria	EP	ABC transporter	dppC	-	-	ko:K02034,ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1,OppC_N
k59_117317_2	981369.JQMJ01000004_gene6022	1.15e-38	139.0	COG0601@1|root,COG0601@2|Bacteria,2GJ2C@201174|Actinobacteria,2NF0H@228398|Streptacidiphilus	201174|Actinobacteria	EP	Binding-protein-dependent transport system inner membrane component	dppB	-	-	ko:K02033,ko:K15581	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1
k59_1562932_1	31033.ENSTRUP00000030341	4.24e-11	67.4	COG0457@1|root,KOG1124@2759|Eukaryota,38CY4@33154|Opisthokonta,3BAFG@33208|Metazoa,3CV6Z@33213|Bilateria,483KS@7711|Chordata,48WWG@7742|Vertebrata,49VMF@7898|Actinopterygii	33208|Metazoa	S	Transmembrane and tetratricopeptide repeat containing 4	TMTC4	-	-	-	-	-	-	-	-	-	-	-	DUF1736,TPR_1,TPR_16,TPR_17,TPR_2,TPR_8
k59_840050_1	555778.Hneap_0183	1.12e-32	122.0	COG0607@1|root,COG0640@1|root,COG0607@2|Bacteria,COG0640@2|Bacteria,1R71B@1224|Proteobacteria,1S2D9@1236|Gammaproteobacteria,1X0QE@135613|Chromatiales	135613|Chromatiales	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5,Rhodanese
k59_784605_1	290318.Cvib_0786	8.76e-47	164.0	COG0454@1|root,COG0456@2|Bacteria,1FDE7@1090|Chlorobi	1090|Chlorobi	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_6525_1	1499968.TCA2_2334	1.71e-45	157.0	COG0600@1|root,COG0600@2|Bacteria,1TRFD@1239|Firmicutes,4HWFW@91061|Bacilli,26T4M@186822|Paenibacillaceae	91061|Bacilli	P	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
k59_284419_1	861299.J421_5993	1.98e-19	90.5	COG0845@1|root,COG0845@2|Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	acrA	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
k59_451285_1	1380394.JADL01000010_gene4147	2.52e-42	142.0	COG0394@1|root,COG0394@2|Bacteria,1RANV@1224|Proteobacteria,2U5EE@28211|Alphaproteobacteria,2JS65@204441|Rhodospirillales	204441|Rhodospirillales	T	Belongs to the low molecular weight phosphotyrosine protein phosphatase family	-	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
k59_451285_2	1121033.AUCF01000013_gene1644	7.44e-25	98.6	COG0424@1|root,COG0424@2|Bacteria,1RH6H@1224|Proteobacteria,2TSS5@28211|Alphaproteobacteria,2JRPN@204441|Rhodospirillales	204441|Rhodospirillales	D	Maf-like protein	maf	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
k59_1618374_1	391038.Bphy_1293	5.84e-56	189.0	COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,2VJ4R@28216|Betaproteobacteria,1K011@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Catalyzes the transformation of hydroxyatrazine to N-isopropylammelide and ethylamine in the atrazine degradation pathway	atzB	-	3.5.4.32	ko:K18456	-	-	-	-	ko00000,ko01000	-	-	-	Amidohydro_1
k59_784616_1	985867.AEWF01000007_gene441	7.48e-112	339.0	COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,2TQWI@28211|Alphaproteobacteria,47EWK@766|Rickettsiales	766|Rickettsiales	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
k59_1618375_1	1469245.JFBG01000026_gene1571	1.1e-76	244.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RZAV@1236|Gammaproteobacteria,1WXBM@135613|Chromatiales	135613|Chromatiales	O	Trypsin	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
k59_20119_1	1120956.JHZK01000033_gene199	1.44e-23	95.1	COG2845@1|root,COG2845@2|Bacteria	2|Bacteria	Q	Protein of unknown function (DUF459)	-	-	-	ko:K16029	ko01051,ko01052,map01051,map01052	-	-	-	ko00000,ko00001	-	-	-	Inh
k59_20119_2	1205680.CAKO01000038_gene1412	2.28e-20	93.2	COG1485@1|root,COG1485@2|Bacteria,1MUUW@1224|Proteobacteria,2TRG1@28211|Alphaproteobacteria,2JPDE@204441|Rhodospirillales	204441|Rhodospirillales	S	AFG1-like ATPase	-	-	-	ko:K06916	-	-	-	-	ko00000,ko03036	-	-	-	AFG1_ATPase
k59_1743052_1	556261.HMPREF0240_02111	8.66e-34	125.0	COG1402@1|root,COG1402@2|Bacteria,1V0N8@1239|Firmicutes,24B66@186801|Clostridia,36W4B@31979|Clostridiaceae	186801|Clostridia	S	Creatinine amidohydrolase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
k59_687720_1	1089439.KB902270_gene2705	1.09e-41	150.0	COG1075@1|root,COG1075@2|Bacteria,1RKW5@1224|Proteobacteria	1224|Proteobacteria	S	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	LCAT,PGAP1
k59_630729_1	69395.JQLZ01000001_gene3056	8.48e-10	62.0	COG1414@1|root,COG1414@2|Bacteria,1R7TS@1224|Proteobacteria,2VEWD@28211|Alphaproteobacteria,2KI5Q@204458|Caulobacterales	204458|Caulobacterales	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
k59_630729_2	743525.TSC_c11540	3.03e-21	87.4	COG0599@1|root,COG0599@2|Bacteria,1WK2N@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
k59_522211_1	1122613.ATUP01000002_gene2493	4.34e-125	377.0	COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,2TRCK@28211|Alphaproteobacteria,43WQW@69657|Hyphomonadaceae	28211|Alphaproteobacteria	E	COG0339 Zn-dependent oligopeptidases	dcp	GO:0003674,GO:0003824,GO:0004180,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0016787,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.15.5	ko:K01284	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
k59_854646_1	717231.Flexsi_1210	1.61e-18	79.7	COG0720@1|root,COG0720@2|Bacteria,2GFPK@200930|Deferribacteres	200930|Deferribacteres	H	6-pyruvoyl tetrahydropterin synthase	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
k59_1578383_1	266264.Rmet_2380	5.89e-07	56.6	COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,2VH1I@28216|Betaproteobacteria,1K0YM@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
k59_800331_1	1122947.FR7_0325	8.62e-70	221.0	COG0745@1|root,COG0745@2|Bacteria,1U3FH@1239|Firmicutes,4H3RA@909932|Negativicutes	909932|Negativicutes	T	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
k59_967123_1	331869.BAL199_02734	2.81e-134	397.0	COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2TQKQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
k59_299814_1	3656.XP_008448895.1	2.31e-05	52.4	COG0457@1|root,KOG0548@2759|Eukaryota,37KEJ@33090|Viridiplantae,3G8SM@35493|Streptophyta,4JNQG@91835|fabids	35493|Streptophyta	O	hsp70-Hsp90 organizing protein	-	GO:0003674,GO:0005488,GO:0005515,GO:0006950,GO:0006986,GO:0008150,GO:0009266,GO:0009408,GO:0009409,GO:0009611,GO:0009628,GO:0009987,GO:0010033,GO:0016043,GO:0022607,GO:0031072,GO:0033554,GO:0034605,GO:0034622,GO:0035966,GO:0042221,GO:0043933,GO:0044085,GO:0050896,GO:0051131,GO:0051716,GO:0051879,GO:0065003,GO:0070417,GO:0070678,GO:0071840	-	ko:K09553	ko05020,map05020	-	-	-	ko00000,ko00001,ko03110	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
k59_689482_1	929713.NIASO_16905	4.91e-34	129.0	COG0304@1|root,COG0304@2|Bacteria,4NEKC@976|Bacteroidetes,1IPBP@117747|Sphingobacteriia	976|Bacteroidetes	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_689482_2	998674.ATTE01000001_gene1690	4.53e-13	63.9	COG0236@1|root,COG0236@2|Bacteria,1MZ4P@1224|Proteobacteria,1S8X4@1236|Gammaproteobacteria,4615Q@72273|Thiotrichales	72273|Thiotrichales	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
k59_1633079_1	1452718.JBOY01000054_gene1977	4.74e-97	300.0	COG0457@1|root,COG0457@2|Bacteria,1N0A9@1224|Proteobacteria,1RZSZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_7
k59_800349_1	1348657.M622_06740	6.56e-105	330.0	COG0842@1|root,COG1129@1|root,COG0842@2|Bacteria,COG1129@2|Bacteria,1QTT9@1224|Proteobacteria,2WGGY@28216|Betaproteobacteria,2KVF7@206389|Rhodocyclales	206389|Rhodocyclales	V	ABC-type multidrug transport system, ATPase component	-	-	-	ko:K13926	-	-	-	-	ko00000	-	-	-	ABC2_membrane_3,ABC_tran
k59_632422_1	240302.BN982_02448	1.32e-63	211.0	COG3534@1|root,COG3534@2|Bacteria,1TR7B@1239|Firmicutes,4HCUX@91061|Bacilli	91061|Bacilli	G	alpha-N-arabinofuranosidase	xsa	-	3.2.1.55	ko:K01209	ko00520,map00520	-	R01762	-	ko00000,ko00001,ko01000	-	GH51	-	Alpha-L-AF_C
k59_1411753_1	671143.DAMO_0571	3.62e-113	340.0	COG0195@1|root,COG0195@2|Bacteria,2NNV1@2323|unclassified Bacteria	2|Bacteria	K	Participates in both transcription termination and antitermination	nusA	GO:0001000,GO:0001121,GO:0001125,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0019904,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043175,GO:0043244,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
k59_967165_1	671143.DAMO_3101	1.36e-26	107.0	COG3705@1|root,COG3705@2|Bacteria,2NQXE@2323|unclassified Bacteria	2|Bacteria	E	Histidyl-tRNA synthetase	hisZ	-	2.4.2.17,6.1.1.21	ko:K00765,ko:K01892,ko:K02502	ko00340,ko00970,ko01100,ko01110,ko01230,map00340,map00970,map01100,map01110,map01230	M00026,M00359,M00360	R01071,R03655	RC00055,RC00523,RC02819,RC03200	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_His
k59_967165_2	671143.DAMO_3100	8.14e-51	175.0	COG0111@1|root,COG0111@2|Bacteria,2NNZW@2323|unclassified Bacteria	2|Bacteria	EH	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
k59_299855_1	1172180.KB911777_gene1405	3.42e-24	97.4	COG3682@1|root,COG3682@2|Bacteria,2IKP5@201174|Actinobacteria	201174|Actinobacteria	K	Pfam Penicillinase repressor	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
k59_1411758_1	1072685.IX83_08695	4.51e-11	60.8	COG0690@1|root,COG0690@2|Bacteria,1RDI9@1224|Proteobacteria,2VUEX@28216|Betaproteobacteria,3T4BY@506|Alcaligenaceae	28216|Betaproteobacteria	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	-	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
k59_1411758_2	1395571.TMS3_0124060	3e-52	169.0	COG0250@1|root,COG0250@2|Bacteria,1MU14@1224|Proteobacteria,1RMW0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Participates in transcription elongation, termination and antitermination	nusG	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043244,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
k59_1134341_2	867845.KI911784_gene1213	4.96e-40	147.0	COG0529@1|root,COG2046@1|root,COG0529@2|Bacteria,COG2046@2|Bacteria,2G7JD@200795|Chloroflexi,376A2@32061|Chloroflexia	32061|Chloroflexia	H	Catalyzes the synthesis of activated sulfate	cysC	-	2.7.7.4	ko:K00958	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase,ATP-sulfurylase,PUA_2
k59_1356392_1	263820.PTO0135	6.85e-18	88.6	COG0515@1|root,arCOG03682@2157|Archaea,2XWZP@28890|Euryarchaeota	28890|Euryarchaeota	T	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	NosD,Pkinase
k59_1578470_2	1121085.AUCI01000002_gene4021	9.25e-17	74.7	29SGJ@1|root,30DMJ@2|Bacteria,1UBFB@1239|Firmicutes,4IMU0@91061|Bacilli,1ZKUH@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_411078_1	1123073.KB899242_gene1292	3.14e-42	144.0	COG1664@1|root,COG1664@2|Bacteria,1MZG6@1224|Proteobacteria,1S826@1236|Gammaproteobacteria,1X74A@135614|Xanthomonadales	135614|Xanthomonadales	M	Integral membrane protein CcmA involved in cell shape determination	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
k59_522324_1	382464.ABSI01000011_gene2491	2.32e-64	209.0	COG0673@1|root,COG0673@2|Bacteria,46TQ2@74201|Verrucomicrobia,2IVP0@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
k59_1578487_1	768671.ThimaDRAFT_4175	1.08e-78	257.0	COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,1RMPC@1236|Gammaproteobacteria,1WXPW@135613|Chromatiales	135613|Chromatiales	O	Belongs to the peptidase S16 family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_32,Lon_C
k59_854763_1	998674.ATTE01000001_gene4144	1.78e-31	124.0	COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,1RMD2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate	-	-	1.1.99.1	ko:K00108	ko00260,ko01100,map00260,map01100	M00555	R01025	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
k59_411114_1	1123023.JIAI01000002_gene5619	6.3e-17	85.1	COG2202@1|root,COG2203@1|root,COG4585@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG4585@2|Bacteria,2I312@201174|Actinobacteria,4DZGK@85010|Pseudonocardiales	201174|Actinobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K02480	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	GAF_2,HAMP,HATPase_c,HisKA_3,PAS_4
k59_854765_1	290397.Adeh_2304	6.03e-43	157.0	COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,42MYN@68525|delta/epsilon subdivisions,2WIND@28221|Deltaproteobacteria,2YUEV@29|Myxococcales	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.8.5.3,1.8.5.5	ko:K07306,ko:K08352	ko00920,ko01120,map00920,map01120	-	R09501,R10149	RC02555,RC02823	ko00000,ko00001,ko01000,ko02000	5.A.3.3,5.A.3.5	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_854765_2	240016.ABIZ01000001_gene604	6.74e-15	70.5	COG1917@1|root,COG1917@2|Bacteria	2|Bacteria	L	Cupin 2, conserved barrel domain protein	-	-	-	ko:K11312	-	-	-	-	ko00000	-	-	-	Cupin_2,Cupin_3
k59_1467597_1	1123242.JH636435_gene1177	1.14e-26	102.0	COG1917@1|root,COG1917@2|Bacteria,2J134@203682|Planctomycetes	203682|Planctomycetes	S	PFAM Cupin 2 conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_912512_1	861299.J421_1863	5.83e-31	126.0	COG0515@1|root,COG3629@1|root,COG0515@2|Bacteria,COG3629@2|Bacteria	2|Bacteria	K	phosphorelay signal transduction system	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	AAA_16,BTAD,TPR_12,Trans_reg_C
k59_689605_1	443143.GM18_0501	5.77e-118	355.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,42Y93@68525|delta/epsilon subdivisions,2WU1Y@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM RNA-directed DNA polymerase (Reverse transcriptase)	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k59_1744895_1	319795.Dgeo_1292	1.97e-26	108.0	COG1307@1|root,COG1307@2|Bacteria,1WIY0@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM Uncharacterised protein, DegV family COG1307	-	-	-	-	-	-	-	-	-	-	-	-	DegV
k59_744847_1	1195236.CTER_3452	4.11e-60	195.0	COG2120@1|root,COG2120@2|Bacteria,1V145@1239|Firmicutes,24FD4@186801|Clostridia,3WNSI@541000|Ruminococcaceae	186801|Clostridia	S	GlcNAc-PI de-N-acetylase	-	-	-	ko:K01463	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
k59_1467602_1	697282.Mettu_4406	5.17e-81	254.0	COG2801@1|root,COG2801@2|Bacteria,1MWVQ@1224|Proteobacteria,1RN12@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_28,HTH_32,rve
k59_1522847_1	1200557.JHWV01000001_gene445	1.45e-40	151.0	COG0768@1|root,COG0768@2|Bacteria,1TQHY@1239|Firmicutes,4H3C8@909932|Negativicutes	909932|Negativicutes	M	Penicillin-binding protein 2	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
k59_632535_1	1144275.COCOR_00022	3.59e-40	149.0	COG2843@1|root,COG2843@2|Bacteria,1Q4SV@1224|Proteobacteria,42ZT3@68525|delta/epsilon subdivisions,2WV46@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Bacterial capsule synthesis protein PGA_cap	-	-	-	-	-	-	-	-	-	-	-	-	PGA_cap
k59_1744914_1	582744.Msip34_0512	2.04e-28	109.0	COG0261@1|root,COG0261@2|Bacteria,1MZEW@1224|Proteobacteria,2VSHZ@28216|Betaproteobacteria,2KMZW@206350|Nitrosomonadales	206350|Nitrosomonadales	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	-	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
k59_354890_1	1043493.BBLU01000008_gene404	8.98e-38	140.0	COG0001@1|root,COG0001@2|Bacteria,2GJSH@201174|Actinobacteria	201174|Actinobacteria	H	Aminotransferase	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_1578552_1	861299.J421_4161	5.31e-07	57.8	COG1747@1|root,COG1747@2|Bacteria,1ZT0K@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	RNA polymerase binding	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_800495_1	1267535.KB906767_gene5335	1.51e-95	294.0	COG3328@1|root,COG3328@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	Transposase_mut
k59_1633235_1	1304878.AUGD01000006_gene6646	4.81e-33	122.0	COG3678@1|root,COG3678@2|Bacteria,1MZKK@1224|Proteobacteria,2UE6S@28211|Alphaproteobacteria,3K0P9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	NPTU	ATP-independent chaperone mediated protein folding	-	-	-	-	-	-	-	-	-	-	-	-	LTXXQ,Metal_resist
k59_132644_1	649638.Trad_0376	4.74e-31	125.0	COG1492@1|root,COG2087@1|root,COG1492@2|Bacteria,COG2087@2|Bacteria,1WJ9J@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation	cobQ	-	6.3.5.10	ko:K02232	ko00860,ko01100,map00860,map01100	M00122	R05225	RC00010,RC01302	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26,CbiA,CobU,GATase_3
k59_1356499_1	251221.35211934	1.04e-128	378.0	COG0719@1|root,COG0719@2|Bacteria,1G0TH@1117|Cyanobacteria	1117|Cyanobacteria	O	ABC-type transport system involved in Fe-S cluster assembly, permease component	sufB	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
k59_522422_1	1487953.JMKF01000006_gene5813	5.84e-94	305.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1G0XM@1117|Cyanobacteria,1H9JF@1150|Oscillatoriales	1117|Cyanobacteria	E	PFAM Conserved region in glutamate synthase	gltB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.7.1	ko:K00284	ko00630,ko00910,ko01120,map00630,map00910,map01120	-	R00021,R10086	RC00006,RC00010	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_411188_1	1038859.AXAU01000002_gene322	1.7e-94	285.0	COG0673@1|root,COG0673@2|Bacteria,1MUP0@1224|Proteobacteria,2TT57@28211|Alphaproteobacteria,3JSAU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_300018_1	330214.NIDE2699	1.92e-71	236.0	COG0367@1|root,COG0367@2|Bacteria	2|Bacteria	E	asparagine synthase	asnB	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
k59_854872_1	485913.Krac_0317	2.76e-87	277.0	COG3547@1|root,COG3547@2|Bacteria	2|Bacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1023375_2	91464.S7335_2718	3.03e-19	82.0	COG1047@1|root,COG1047@2|Bacteria,1G5R4@1117|Cyanobacteria,1H3C2@1129|Synechococcus	1117|Cyanobacteria	O	FKBP-type peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	FKBP_C
k59_632616_1	439481.Aboo_1400	3.04e-20	93.2	COG1506@1|root,arCOG01646@2157|Archaea	2157|Archaea	E	Peptidase S9 prolyl oligopeptidase active site	-	-	3.4.14.11	ko:K01281	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Abhydrolase_1
k59_300061_1	1288826.MSNKSG1_13557	4.06e-06	47.4	COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,1RQ5E@1236|Gammaproteobacteria,466CU@72275|Alteromonadaceae	1236|Gammaproteobacteria	NT	COG1352 Methylase of chemotaxis methyl-accepting proteins	pilK	-	2.1.1.80	ko:K00575,ko:K02661	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035,ko02044	-	-	-	CheR,CheR_N
k59_300061_2	225937.HP15_3518	6.71e-105	337.0	COG0643@1|root,COG0784@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,4650G@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	COG0643 Chemotaxis protein histidine kinase and related kinases	chpA	-	-	ko:K02487,ko:K06596	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg
k59_1744995_1	1206731.BAGB01000157_gene5868	3.06e-34	124.0	COG0500@1|root,COG0500@2|Bacteria,2GX4K@201174|Actinobacteria,4G9PR@85025|Nocardiaceae	201174|Actinobacteria	Q	Thiopurine S-methyltransferase (TPMT)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,TPMT
k59_354993_1	373994.Riv7116_3289	1.54e-37	143.0	COG2133@1|root,COG2133@2|Bacteria,1G39K@1117|Cyanobacteria,1HR5R@1161|Nostocales	1117|Cyanobacteria	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
k59_1633320_1	234267.Acid_1054	2.51e-62	201.0	COG1397@1|root,COG1397@2|Bacteria,3Y94D@57723|Acidobacteria	57723|Acidobacteria	O	ADP-ribosylglycohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH
k59_77451_1	1033730.CAHG01000012_gene2094	1.11e-06	50.4	COG2197@1|root,COG2197@2|Bacteria,2IA77@201174|Actinobacteria,4DWM2@85009|Propionibacteriales	201174|Actinobacteria	KT	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_1578658_1	555217.Zmob_1582	4.97e-61	208.0	COG1657@1|root,COG1657@2|Bacteria,1MUIP@1224|Proteobacteria,2TRF3@28211|Alphaproteobacteria,2K06U@204457|Sphingomonadales	204457|Sphingomonadales	I	PFAM Prenyltransferase squalene oxidase	-	-	4.2.1.129,5.4.99.17	ko:K06045	ko00909,ko01110,map00909,map01110	-	R07322,R07323	RC01850,RC01851	ko00000,ko00001,ko01000	-	-	-	SQHop_cyclase_C,SQHop_cyclase_N
k59_411264_1	521098.Aaci_0537	2.03e-41	142.0	COG0394@1|root,COG0394@2|Bacteria,1V3JW@1239|Firmicutes,4HH49@91061|Bacilli,278FI@186823|Alicyclobacillaceae	91061|Bacilli	T	PFAM Protein-tyrosine phosphatase, low molecular weight	arsC	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0008794,GO:0016491,GO:0030611,GO:0030613,GO:0030614,GO:0042221,GO:0046685,GO:0050896,GO:0055114	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
k59_300078_1	472175.EL18_00667	6.25e-74	245.0	COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2TQP0@28211|Alphaproteobacteria,43HW8@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	Belongs to the ABC transporter superfamily	gsiA3	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_1633332_1	1254432.SCE1572_03080	5.23e-105	337.0	COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,42NAW@68525|delta/epsilon subdivisions,2WISU@28221|Deltaproteobacteria,2YUJI@29|Myxococcales	28221|Deltaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_1300760_1	1005048.CFU_0238	1.83e-13	73.2	COG2706@1|root,COG2706@2|Bacteria,1MWGS@1224|Proteobacteria,2VKJU@28216|Betaproteobacteria,4760F@75682|Oxalobacteraceae	28216|Betaproteobacteria	G	Lactonase, 7-bladed beta-propeller	-	-	3.1.1.31	ko:K07404	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Lactonase
k59_1467744_1	1461694.ATO9_18795	1.44e-22	93.6	COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,2PDBD@252301|Oceanicola	28211|Alphaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve,rve_3
k59_1356594_1	521098.Aaci_1994	4.05e-35	132.0	COG2264@1|root,COG2264@2|Bacteria,1TPKI@1239|Firmicutes,4HAMF@91061|Bacilli,278D7@186823|Alicyclobacillaceae	91061|Bacilli	J	Ribosomal protein L11 methyltransferase	prmA	-	-	ko:K02687	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PrmA
k59_1647989_1	266117.Rxyl_1174	7.72e-05	50.1	COG1178@1|root,COG1178@2|Bacteria,2GKPT@201174|Actinobacteria	201174|Actinobacteria	P	Binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
k59_1094472_1	485913.Krac_6795	1.43e-60	196.0	COG1013@1|root,COG1013@2|Bacteria,2G679@200795|Chloroflexi	200795|Chloroflexi	C	PFAM thiamine pyrophosphate protein domain protein TPP-binding	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
k59_870917_1	404589.Anae109_2537	2.29e-116	352.0	COG2766@1|root,COG2766@2|Bacteria,1MVW7@1224|Proteobacteria,42NBQ@68525|delta/epsilon subdivisions,2WKR5@28221|Deltaproteobacteria,2YUIB@29|Myxococcales	28221|Deltaproteobacteria	T	PrkA AAA domain	prkA	-	-	ko:K07180	-	-	-	-	ko00000	-	-	-	AAA_PrkA,PrkA
k59_592998_1	880073.Calab_2352	9.08e-117	347.0	COG0334@1|root,COG0334@2|Bacteria,2NNTY@2323|unclassified Bacteria	2|Bacteria	E	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase	gdhA	-	1.4.1.4	ko:K00262	ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100	-	R00248	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
k59_316911_3	926569.ANT_14100	3.97e-25	106.0	COG0628@1|root,COG0628@2|Bacteria,2G6TV@200795|Chloroflexi	200795|Chloroflexi	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
k59_815907_1	1463853.JOHW01000002_gene5670	4.06e-62	208.0	COG1129@1|root,COG1129@2|Bacteria,2GJ3F@201174|Actinobacteria	201174|Actinobacteria	G	Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system	-	-	3.6.3.17	ko:K02056,ko:K10441	ko02010,map02010	M00212,M00221	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
k59_93023_2	340177.Cag_1476	1.71e-12	69.3	COG0438@1|root,COG0438@2|Bacteria,1FD90@1090|Chlorobi	1090|Chlorobi	H	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
k59_537977_1	1173020.Cha6605_5435	1.22e-97	303.0	COG1898@1|root,COG4310@1|root,COG1898@2|Bacteria,COG4310@2|Bacteria,1G39N@1117|Cyanobacteria	1117|Cyanobacteria	M	Domain of unknown function (DUF4910)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2172,DUF4910,HTH_47
k59_1150508_1	671143.DAMO_1846	1.73e-66	224.0	COG5009@1|root,COG5009@2|Bacteria,2NS4K@2323|unclassified Bacteria	2|Bacteria	M	Transglycosylase	mrcA	GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0008955,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042546,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	iAF987.Gmet_0354	PCB_OB,Transgly,Transpeptidase
k59_930036_1	502025.Hoch_2745	2.3e-05	47.0	28NPB@1|root,2ZBP9@2|Bacteria,1R3HY@1224|Proteobacteria,43BB6@68525|delta/epsilon subdivisions,2X6QB@28221|Deltaproteobacteria,2YYYB@29|Myxococcales	28221|Deltaproteobacteria	S	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_1
k59_930036_2	1123009.AUID01000001_gene1131	3.73e-51	172.0	COG0604@1|root,COG0604@2|Bacteria,1TPGR@1239|Firmicutes,24AAD@186801|Clostridia,26AWR@186813|unclassified Clostridiales	186801|Clostridia	C	Zinc-binding dehydrogenase	-	-	-	ko:K19745	ko00640,ko01100,map00640,map01100	-	R00919	RC00095	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_316937_1	935837.JAEK01000032_gene2599	2.79e-79	247.0	COG0673@1|root,COG0673@2|Bacteria,1TNYR@1239|Firmicutes,4HAZU@91061|Bacilli,1ZCPS@1386|Bacillus	91061|Bacilli	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_1150527_1	671143.DAMO_2847	1.06e-170	484.0	COG0180@1|root,COG0180@2|Bacteria,2NNQX@2323|unclassified Bacteria	2|Bacteria	J	tRNA synthetases class I (W and Y)	trpS	GO:0003674,GO:0003824,GO:0004812,GO:0004830,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006436,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
k59_984579_1	1049564.TevJSym_ab01020	8.41e-37	134.0	2A20V@1|root,30QAU@2|Bacteria,1RDQH@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_815957_1	694431.DESACE_06435	4.65e-71	225.0	COG2876@1|root,COG2876@2|Bacteria,1QVAD@1224|Proteobacteria,42MU4@68525|delta/epsilon subdivisions,2WJ8Y@28221|Deltaproteobacteria,2M6FY@213113|Desulfurellales	28221|Deltaproteobacteria	E	NeuB family	aroG-2	-	2.5.1.54,5.4.99.5	ko:K03856,ko:K04516	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022,M00024,M00025	R01715,R01826	RC00435,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_2,DAHP_synth_1
k59_316970_1	1120792.JAFV01000001_gene3184	3.19e-36	131.0	COG4763@1|root,COG4763@2|Bacteria,1Q61M@1224|Proteobacteria,2TR19@28211|Alphaproteobacteria,36ZC5@31993|Methylocystaceae	28211|Alphaproteobacteria	S	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
k59_316970_2	977880.RALTA_A2267	7.42e-36	136.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2VHKU@28216|Betaproteobacteria,1K17A@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	tctA4	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
k59_1484010_1	1278073.MYSTI_02349	2.98e-32	119.0	COG1428@1|root,COG1428@2|Bacteria,1RC50@1224|Proteobacteria	1224|Proteobacteria	F	Deoxynucleoside kinase	dgk	-	-	-	-	-	-	-	-	-	-	-	dNK
k59_259095_1	384765.SIAM614_07383	1.66e-115	341.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TS1R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Belongs to the thiolase family	fadA	GO:0003674,GO:0003824,GO:0003988,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0006725,GO:0006805,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009404,GO:0009407,GO:0009410,GO:0009636,GO:0009850,GO:0009852,GO:0009987,GO:0010124,GO:0010817,GO:0016020,GO:0016042,GO:0016054,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0019395,GO:0019439,GO:0019748,GO:0019752,GO:0030258,GO:0030312,GO:0032787,GO:0033554,GO:0033812,GO:0034440,GO:0042178,GO:0042221,GO:0042445,GO:0042447,GO:0042537,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044464,GO:0046395,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071466,GO:0071704,GO:0071944,GO:0072329,GO:0098754,GO:1901360,GO:1901361,GO:1901575	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_984604_1	102129.Lepto7375DRAFT_2614	2.01e-23	97.1	2CCSR@1|root,32RWC@2|Bacteria,1GA04@1117|Cyanobacteria,1HDA0@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM S23 ribosomal protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
k59_760230_1	366602.Caul_5358	5.99e-10	60.5	COG3547@1|root,COG3547@2|Bacteria,1Q4TE@1224|Proteobacteria,2TT7C@28211|Alphaproteobacteria,2KIIT@204458|Caulobacterales	204458|Caulobacterales	L	Transposase IS116/IS110/IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_20
k59_1150561_1	1382306.JNIM01000001_gene4159	1.46e-57	194.0	COG0114@1|root,COG0114@2|Bacteria,2GBNI@200795|Chloroflexi	200795|Chloroflexi	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	-	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
k59_815971_1	745310.G432_15550	5.86e-14	70.1	COG1309@1|root,COG1309@2|Bacteria,1NM2A@1224|Proteobacteria,2VE44@28211|Alphaproteobacteria,2K3MQ@204457|Sphingomonadales	204457|Sphingomonadales	K	Bacterial regulatory proteins, tetR family	-	-	-	ko:K09017	-	-	-	-	ko00000,ko03000	-	-	-	TetR_N
k59_815971_3	1341646.CBMO010000137_gene2321	3.3e-11	63.2	COG2124@1|root,COG2124@2|Bacteria,2GKKN@201174|Actinobacteria,23477@1762|Mycobacteriaceae	201174|Actinobacteria	Q	cytochrome p450	-	-	1.14.15.13	ko:K17474	-	-	-	-	ko00000,ko00199,ko01000	-	-	-	p450
k59_871006_1	404589.Anae109_3542	1.58e-28	109.0	2DN8B@1|root,32W2U@2|Bacteria,1R03I@1224|Proteobacteria,42XCH@68525|delta/epsilon subdivisions,2WT8A@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_984626_1	929556.Solca_0522	5.02e-81	256.0	COG1032@1|root,COG1032@2|Bacteria,4PHMM@976|Bacteroidetes,1IWI2@117747|Sphingobacteriia	976|Bacteroidetes	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_317001_1	1120972.AUMH01000013_gene2398	3.5e-32	122.0	COG0673@1|root,COG0673@2|Bacteria,1TPT5@1239|Firmicutes,4HAPJ@91061|Bacilli	91061|Bacilli	S	oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_1263109_1	1313172.YM304_05680	8.84e-27	102.0	2AEFI@1|root,314AK@2|Bacteria,2HDRV@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1595078_1	886293.Sinac_0956	1.6e-87	285.0	COG2010@1|root,COG2010@2|Bacteria,2IWY5@203682|Planctomycetes	203682|Planctomycetes	C	Planctomycete cytochrome C	-	-	-	-	-	-	-	-	-	-	-	-	PA14,PSCyt1,PSCyt2,PSD1
k59_538080_1	69293.ENSGACP00000005907	2.69e-05	46.6	COG0044@1|root,KOG2584@2759|Eukaryota,38CFY@33154|Opisthokonta,3BD2V@33208|Metazoa,3CY3E@33213|Bilateria,488TX@7711|Chordata,498VB@7742|Vertebrata,49Y0D@7898|Actinopterygii	33208|Metazoa	F	Zgc 103559	-	GO:0003674,GO:0003824,GO:0004038,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0019439,GO:0034641,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575	3.5.2.5	ko:K01466	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R02425	RC00680	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
k59_538080_2	1094980.Mpsy_2203	1.16e-17	82.0	COG3247@1|root,arCOG03582@2157|Archaea,2Y5FW@28890|Euryarchaeota,2NBDS@224756|Methanomicrobia	224756|Methanomicrobia	S	Short repeat of unknown function (DUF308)	-	-	-	-	-	-	-	-	-	-	-	-	DUF308
k59_37070_1	526225.Gobs_2966	3.25e-47	167.0	COG0508@1|root,COG0508@2|Bacteria,2GM0D@201174|Actinobacteria	201174|Actinobacteria	C	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_317026_2	1121007.AUML01000025_gene7	1.55e-16	80.1	COG5002@1|root,COG5002@2|Bacteria,4PKV1@976|Bacteroidetes,1IKKI@117743|Flavobacteriia	976|Bacteroidetes	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,GAF_2,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
k59_760279_1	379066.GAU_2003	1.23e-50	176.0	COG0591@1|root,COG0591@2|Bacteria,1ZTEB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Sodium:solute symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
k59_593133_1	1408473.JHXO01000008_gene2813	7.88e-22	95.1	COG2091@1|root,COG2091@2|Bacteria,4NFQ6@976|Bacteroidetes,2FS4M@200643|Bacteroidia	976|Bacteroidetes	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
k59_593133_2	1242864.D187_002602	1.91e-16	79.0	COG0006@1|root,COG0006@2|Bacteria,1MVHD@1224|Proteobacteria	1224|Proteobacteria	E	Xaa-Pro aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M24
k59_259172_1	469371.Tbis_2599	5.02e-76	241.0	COG1032@1|root,COG1032@2|Bacteria,2HW71@201174|Actinobacteria,4E7P4@85010|Pseudonocardiales	201174|Actinobacteria	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
k59_1372792_1	1463879.JOHP01000005_gene5999	1.22e-07	58.5	COG2159@1|root,COG2159@2|Bacteria,2HEB4@201174|Actinobacteria	201174|Actinobacteria	CH	amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
k59_1150635_1	1260251.SPISAL_05805	1.67e-115	355.0	COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,1RM9A@1236|Gammaproteobacteria,1WWP6@135613|Chromatiales	135613|Chromatiales	D	DNA segregation ATPase FtsK SpoIIIE	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
k59_1263167_1	869213.JCM21142_52192	4.29e-23	97.1	COG1012@1|root,COG1012@2|Bacteria,4NFPJ@976|Bacteroidetes,47JJR@768503|Cytophagia	976|Bacteroidetes	C	Belongs to the aldehyde dehydrogenase family	pcd	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_1648168_1	1121896.JMLU01000001_gene1093	2.99e-06	55.5	COG1747@1|root,COG1747@2|Bacteria,4NEB8@976|Bacteroidetes,1HXVQ@117743|Flavobacteriia,2NU0A@237|Flavobacterium	976|Bacteroidetes	S	SprA protein	sprA	-	-	-	-	-	-	-	-	-	-	-	SprA_N
k59_1150654_1	1144275.COCOR_04241	2.31e-28	108.0	COG0652@1|root,COG0652@2|Bacteria,1RENS@1224|Proteobacteria,42RIB@68525|delta/epsilon subdivisions,2X5WM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K03767	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
k59_1263198_1	1449076.JOOE01000004_gene393	7.28e-25	107.0	COG2819@1|root,COG2819@2|Bacteria,1R9SG@1224|Proteobacteria,2U7D0@28211|Alphaproteobacteria,2K715@204457|Sphingomonadales	204457|Sphingomonadales	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
k59_1648189_1	1519464.HY22_08510	4.91e-15	79.3	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
k59_593189_2	324602.Caur_1958	9.37e-34	122.0	2E3MN@1|root,302XP@2|Bacteria,2G95X@200795|Chloroflexi,377TT@32061|Chloroflexia	32061|Chloroflexia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1318190_1	861299.J421_4119	1.77e-37	139.0	COG0534@1|root,COG0534@2|Bacteria,1ZT8D@142182|Gemmatimonadetes	142182|Gemmatimonadetes	V	MatE	-	-	-	-	-	-	-	-	-	-	-	-	MatE
k59_706138_1	1001585.MDS_2343	7.19e-31	121.0	COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,1RR72@1236|Gammaproteobacteria,1YCSG@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	G	transporter	dctP	GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0008150,GO:0015711,GO:0015740,GO:0015849,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464,GO:0046942,GO:0051179,GO:0051234,GO:0071702	-	ko:K11688	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctP
k59_930234_1	1283283.ATXA01000001_gene539	0.000117	43.5	2E35Q@1|root,32Y5M@2|Bacteria,2GS2Q@201174|Actinobacteria,4ETIJ@85013|Frankiales	201174|Actinobacteria	S	Short C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	SHOCT
k59_930234_2	471853.Bcav_0736	2.78e-26	103.0	COG4803@1|root,COG4803@2|Bacteria,2IIN1@201174|Actinobacteria	201174|Actinobacteria	S	membrane protein of uknown function UCP014873	-	-	-	-	-	-	-	-	-	-	-	-	SHOCT
k59_1538236_1	794903.OPIT5_02510	6.05e-20	93.6	COG4974@1|root,COG4974@2|Bacteria,46UB9@74201|Verrucomicrobia,3K9DD@414999|Opitutae	414999|Opitutae	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
k59_203257_1	1128421.JAGA01000003_gene3678	7.76e-38	145.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2NQCZ@2323|unclassified Bacteria	2|Bacteria	K	NB-ARC domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,AAA_22,BTAD,NB-ARC,TPR_10,TPR_12,TPR_8,Trans_reg_C
k59_1372873_1	1193181.BN10_920037	0.00016	43.5	COG0251@1|root,COG0251@2|Bacteria,2IIB2@201174|Actinobacteria,4FHUK@85021|Intrasporangiaceae	201174|Actinobacteria	J	Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
k59_1372873_2	85643.Tmz1t_2130	6.66e-67	216.0	COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,2VJ89@28216|Betaproteobacteria,2KVYN@206389|Rhodocyclales	206389|Rhodocyclales	S	tRNA-splicing ligase RtcB	-	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
k59_871152_1	386415.NT01CX_1268	2.27e-53	180.0	COG3958@1|root,COG3958@2|Bacteria,1V0K5@1239|Firmicutes,24914@186801|Clostridia,36E9P@31979|Clostridiaceae	186801|Clostridia	G	Transketolase	tktB	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
k59_1648237_1	926569.ANT_03630	2.56e-09	58.2	COG5322@1|root,COG5322@2|Bacteria,2G8N0@200795|Chloroflexi	200795|Chloroflexi	S	PFAM Shikimate quinate 5-dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Shikimate_DH
k59_1648237_2	926569.ANT_03640	1.38e-33	125.0	COG0746@1|root,COG0746@2|Bacteria	2|Bacteria	H	molybdenum cofactor guanylyltransferase activity	mobA	GO:0003674,GO:0003824,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0071704,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.7.77	ko:K03752,ko:K13818	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
k59_706179_1	331869.BAL199_06664	2.19e-29	117.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TSN5@28211|Alphaproteobacteria,4BR7H@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	4Fe-4S dicluster domain	MA20_43170	-	-	-	-	-	-	-	-	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_8
k59_706179_2	391613.RTM1035_19186	7.38e-36	131.0	COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,2TQSN@28211|Alphaproteobacteria,46PP8@74030|Roseovarius	28211|Alphaproteobacteria	E	COG0075 Serine-pyruvate aminotransferase archaeal aspartate aminotransferase	-	-	2.6.1.44,2.6.1.45,2.6.1.51	ko:K00830	ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	M00346,M00532	R00369,R00372,R00585,R00588	RC00006,RC00008,RC00018	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
k59_1648250_1	1123247.AUIJ01000001_gene1731	1.84e-116	342.0	COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,2TS5C@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Part of the tripartite ATP-independent periplasmic (TRAP) transport system	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_984794_1	880073.Calab_2438	2.74e-87	275.0	COG0443@1|root,COG0443@2|Bacteria,2NNU1@2323|unclassified Bacteria	2|Bacteria	O	Heat shock 70 kDa protein	dnaK	GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0018995,GO:0019219,GO:0019222,GO:0020003,GO:0022607,GO:0030430,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0033643,GO:0033646,GO:0033655,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043230,GO:0043531,GO:0043656,GO:0043657,GO:0043933,GO:0044085,GO:0044183,GO:0044215,GO:0044216,GO:0044217,GO:0044421,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0065010,GO:0070887,GO:0071310,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
k59_93327_1	373994.Riv7116_5283	2.35e-112	337.0	COG1012@1|root,COG1012@2|Bacteria,1G09W@1117|Cyanobacteria,1HMAB@1161|Nostocales	1117|Cyanobacteria	C	Aldehyde dehydrogenase family	-	-	1.2.1.18,1.2.1.27	ko:K00140	ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200	M00013	R00705,R00706,R00922,R00935	RC00004,RC02723,RC02817	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_1318282_1	1519464.HY22_13740	5.74e-16	79.3	COG1079@1|root,COG1079@2|Bacteria,1FDHG@1090|Chlorobi	1090|Chlorobi	P	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
k59_538258_2	717773.Thicy_0196	2.42e-22	93.6	COG0396@1|root,COG0396@2|Bacteria,1MUGK@1224|Proteobacteria,1RPFE@1236|Gammaproteobacteria,45ZRE@72273|Thiotrichales	72273|Thiotrichales	O	FeS assembly ATPase SufC	sufC	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
k59_1094772_1	443143.GM18_0465	3.66e-05	45.4	COG1668@1|root,COG1668@2|Bacteria,1QZ6M@1224|Proteobacteria	1224|Proteobacteria	CP	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
k59_1094772_2	1123288.SOV_6c01010	2.33e-33	126.0	COG1131@1|root,COG1131@2|Bacteria,1TQKM@1239|Firmicutes,4H3CG@909932|Negativicutes	909932|Negativicutes	V	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
k59_760453_1	331869.BAL199_08288	5e-23	95.5	COG1082@1|root,COG1082@2|Bacteria,1Q173@1224|Proteobacteria,2TTFM@28211|Alphaproteobacteria,4BQK3@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
k59_760453_2	384765.SIAM614_09558	9.82e-45	151.0	COG0834@1|root,COG0834@2|Bacteria,1MVT6@1224|Proteobacteria,2TU5Z@28211|Alphaproteobacteria	28211|Alphaproteobacteria	ET	belongs to the bacterial solute-binding protein 3 family	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
k59_1539993_1	1048339.KB913029_gene69	5.71e-96	286.0	COG0479@1|root,COG0479@2|Bacteria,2GP9C@201174|Actinobacteria,4ERFH@85013|Frankiales	201174|Actinobacteria	C	Succinate dehydrogenase and fumarate reductase iron-sulfur protein	sdhB1	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv0247c	Fer2_3,Fer4_8
k59_275470_1	105559.Nwat_1090	1.29e-80	267.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,1WW84@135613|Chromatiales	135613|Chromatiales	E	Vitamin B12 dependent methionine synthase activation	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_55137_2	1122137.AQXF01000005_gene1270	2.29e-22	90.1	2E42N@1|root,32YZ4@2|Bacteria,1NB0A@1224|Proteobacteria,2UHGU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_218897_1	1267005.KB911258_gene398	5.15e-05	48.5	COG5612@1|root,COG5612@2|Bacteria,1NGG9@1224|Proteobacteria,2UJA4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Heavy-metal resistance	-	-	-	-	-	-	-	-	-	-	-	-	Metal_resist
k59_1723110_2	314345.SPV1_07606	2.67e-49	165.0	COG0451@1|root,COG0451@2|Bacteria,1MXKV@1224|Proteobacteria	1224|Proteobacteria	GM	Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides	rmlB2	-	4.1.1.35,4.2.1.46	ko:K01710,ko:K08678	ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00520,map00521,map00523,map00525,map01055,map01100,map01130	M00361,M00793	R01384,R06513	RC00402,RC00508	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
k59_554787_1	1242864.D187_001113	1.2e-22	101.0	COG0654@1|root,COG0654@2|Bacteria,1MUN4@1224|Proteobacteria,43EZ5@68525|delta/epsilon subdivisions,2X2Q4@28221|Deltaproteobacteria,2YUCS@29|Myxococcales	28221|Deltaproteobacteria	CH	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
k59_218928_1	338966.Ppro_0970	5.32e-58	186.0	COG1778@1|root,COG1778@2|Bacteria,1RH85@1224|Proteobacteria,42SN2@68525|delta/epsilon subdivisions,2WPT4@28221|Deltaproteobacteria,43UYH@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family	kdsC	-	3.1.3.45	ko:K03270	ko00540,ko01100,map00540,map01100	M00063	R03350	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase_3
k59_111085_1	35841.BT1A1_0464	0.000521	43.5	COG1175@1|root,COG1175@2|Bacteria,1UPAZ@1239|Firmicutes,4HCFS@91061|Bacilli,1ZQ7K@1386|Bacillus	91061|Bacilli	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
k59_111085_2	649638.Trad_1729	3.5e-15	75.9	COG1653@1|root,COG1653@2|Bacteria,1WM3Y@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K10188	ko02010,map02010	M00199	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.4	-	-	SBP_bac_1
k59_1723152_1	671143.DAMO_2140	6.32e-17	79.3	COG0505@1|root,COG0505@2|Bacteria,2NNMS@2323|unclassified Bacteria	2|Bacteria	F	Belongs to the CarA family	carA	GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005951,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0019627,GO:0019752,GO:0032991,GO:0034641,GO:0040007,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1383	CPSase_sm_chain,GATase
k59_1723152_2	66692.ABC2338	1.55e-26	105.0	COG2065@1|root,COG2065@2|Bacteria,1V3GV@1239|Firmicutes,4HGYE@91061|Bacilli,1ZB3P@1386|Bacillus	91061|Bacilli	F	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant	pyrR	GO:0003674,GO:0003700,GO:0006139,GO:0006220,GO:0006221,GO:0006355,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019637,GO:0019693,GO:0031323,GO:0031326,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0055086,GO:0060255,GO:0065007,GO:0071704,GO:0072527,GO:0072528,GO:0080090,GO:0090407,GO:0140110,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:2000112,GO:2001141	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000,ko03000	-	-	-	Pribosyltran
k59_111114_1	1288963.ADIS_4110	7.06e-42	146.0	COG0179@1|root,COG0179@2|Bacteria,4NFMZ@976|Bacteroidetes,47N4F@768503|Cytophagia	976|Bacteroidetes	Q	PFAM fumarylacetoacetate (FAA) hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
k59_111114_2	762903.Pedsa_0486	1.29e-11	63.2	COG1028@1|root,COG1028@2|Bacteria,4NH6Y@976|Bacteroidetes,1IQBS@117747|Sphingobacteriia	976|Bacteroidetes	IQ	short-chain dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_1554600_1	313596.RB2501_05185	4.07e-74	238.0	COG2234@1|root,COG2234@2|Bacteria,4NE66@976|Bacteroidetes,1HYK4@117743|Flavobacteriia	976|Bacteroidetes	S	Peptidase m28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
k59_609397_1	448385.sce7100	6.21e-85	267.0	COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,42MA8@68525|delta/epsilon subdivisions,2WIXR@28221|Deltaproteobacteria,2YUA9@29|Myxococcales	28221|Deltaproteobacteria	S	Circularly permuted ATP-grasp type 2	-	-	-	-	-	-	-	-	-	-	-	-	CP_ATPgrasp_2
k59_609398_1	1265503.KB905161_gene3232	1.48e-07	58.2	COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,1RNB8@1236|Gammaproteobacteria,2Q67A@267889|Colwelliaceae	1236|Gammaproteobacteria	O	Bacterial pre-peptidase C-terminal domain	-	-	-	ko:K14645	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Inhibitor_I9,PA,PPC,P_proprotein,Peptidase_S8
k59_111152_2	694431.DESACE_07205	2.17e-30	115.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,42P5P@68525|delta/epsilon subdivisions,2WITN@28221|Deltaproteobacteria,2M7PQ@213113|Desulfurellales	28221|Deltaproteobacteria	E	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Fer4_9,Pyr_redox_2
k59_777287_1	1392490.JHZX01000001_gene426	3.1e-84	252.0	COG0290@1|root,COG0290@2|Bacteria,4NIZ5@976|Bacteroidetes,1I178@117743|Flavobacteriia	976|Bacteroidetes	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
k59_1554639_1	861299.J421_5619	3.48e-50	176.0	COG5434@1|root,COG5434@2|Bacteria	2|Bacteria	M	polygalacturonase activity	-	-	3.2.1.15	ko:K01184	ko00040,ko01100,map00040,map01100	M00081	R01982,R02360	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_28,Pectate_lyase_3
k59_609440_1	742765.HMPREF9457_03693	9.85e-36	139.0	COG3344@1|root,COG3344@2|Bacteria,1TP9A@1239|Firmicutes,248M4@186801|Clostridia	186801|Clostridia	L	Reverse transcriptase	-	-	-	-	-	-	-	-	-	-	-	-	Intron_maturas2,RVT_1
k59_609454_1	1116472.MGMO_61c00230	4.57e-26	106.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,1RNS6@1236|Gammaproteobacteria,1XE9P@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	bioF	-	2.3.1.47	ko:K00652	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03210,R10124	RC00004,RC00039,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_609454_2	1177181.T9A_00667	1.5e-49	169.0	COG0502@1|root,COG0502@2|Bacteria,1MVFF@1224|Proteobacteria,1RMEQ@1236|Gammaproteobacteria,1XI08@135619|Oceanospirillales	135619|Oceanospirillales	H	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism	bioB	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	BATS,Radical_SAM
k59_777355_2	1282360.ABAC460_03155	1.87e-10	64.3	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,2KFYE@204458|Caulobacterales	204458|Caulobacterales	L	Transposase IS116/IS110/IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_55307_1	394221.Mmar10_0004	2.7e-10	65.9	COG1266@1|root,COG1266@2|Bacteria,1R5RA@1224|Proteobacteria,2UKBY@28211|Alphaproteobacteria,43YTK@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
k59_1666628_1	290400.Jann_1801	4.95e-18	86.7	COG0697@1|root,COG0697@2|Bacteria,1R6KH@1224|Proteobacteria,2TTBR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EG	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	MA20_23245	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_609514_1	383372.Rcas_1205	2.2e-60	203.0	COG0449@1|root,COG0449@2|Bacteria,2G5T5@200795|Chloroflexi,374VE@32061|Chloroflexia	32061|Chloroflexia	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
k59_609514_2	644966.Tmar_0462	1.42e-13	73.6	COG0038@1|root,COG0517@1|root,COG0038@2|Bacteria,COG0517@2|Bacteria,1TPX0@1239|Firmicutes,247R4@186801|Clostridia,3WDH0@538999|Clostridiales incertae sedis	186801|Clostridia	P	Voltage gated chloride channel	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,Voltage_CLC
k59_1723297_1	926569.ANT_18490	2.45e-44	151.0	COG0785@1|root,COG0785@2|Bacteria,2G6V3@200795|Chloroflexi	200795|Chloroflexi	O	PFAM cytochrome c biogenesis protein, transmembrane region	ccdA	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	DsbD
k59_1666671_1	926569.ANT_26040	4.44e-45	154.0	COG5433@1|root,COG5433@2|Bacteria,2G91G@200795|Chloroflexi	200795|Chloroflexi	L	DDE_Tnp_1-associated	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_assoc
k59_1222253_1	992406.RIA_1861	2.9e-46	165.0	COG1253@1|root,COG1253@2|Bacteria,4NDZ7@976|Bacteroidetes,1HXF3@117743|Flavobacteriia	976|Bacteroidetes	S	gliding motility-associated protein GldE	gldE	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
k59_275795_1	224911.27355733	6.06e-81	253.0	COG4307@1|root,COG4307@2|Bacteria,1MXES@1224|Proteobacteria,2U06R@28211|Alphaproteobacteria,3JRXQ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Putative zinc-binding metallo-peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_Mx
k59_777445_1	195253.Syn6312_0412	5.87e-12	65.1	COG0497@1|root,COG0497@2|Bacteria,1G0D4@1117|Cyanobacteria,1GYQE@1129|Synechococcus	1117|Cyanobacteria	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SMC_N
k59_777445_2	1480694.DC28_02190	1.29e-27	110.0	COG0061@1|root,COG0061@2|Bacteria,2J5BE@203691|Spirochaetes	203691|Spirochaetes	H	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
k59_275824_1	318996.AXAZ01000073_gene3360	7.09e-51	175.0	COG4301@1|root,COG4301@2|Bacteria,1MUCG@1224|Proteobacteria,2TRMH@28211|Alphaproteobacteria,3JRIF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Histidine-specific methyltransferase, SAM-dependent	MA20_09135	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_33
k59_1666747_1	485916.Dtox_1350	3.9e-15	80.9	COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,26166@186807|Peptococcaceae	186801|Clostridia	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Fer4_7,NAD_binding_8,Pyr_redox_2
k59_275861_1	1123371.ATXH01000030_gene2007	2.78e-83	261.0	COG0215@1|root,COG0215@2|Bacteria,2GGZ1@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	-	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
k59_555079_1	237368.SCABRO_04028	2.25e-63	207.0	COG0644@1|root,COG0664@1|root,COG0644@2|Bacteria,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	prnA	-	1.14.19.9	ko:K07058,ko:K14266	ko00404,ko01130,map00404,map01130	M00789,M00790	R09570	RC00949	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_5,Trp_halogenase,cNMP_binding
k59_1222371_1	56780.SYN_01454	2.44e-79	261.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,42MKB@68525|delta/epsilon subdivisions,2WJ4W@28221|Deltaproteobacteria,2MQ7V@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
k59_1554905_1	926569.ANT_05370	1.37e-36	134.0	COG2723@1|root,COG2723@2|Bacteria,2G5QE@200795|Chloroflexi	200795|Chloroflexi	G	PFAM glycoside hydrolase, family 1	-	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1
k59_1554905_2	357808.RoseRS_1604	1.08e-18	87.4	COG3570@1|root,COG3570@2|Bacteria,2G7VJ@200795|Chloroflexi	200795|Chloroflexi	H	PFAM aminoglycoside hydroxyurea antibiotic resistance kinase	-	-	2.7.1.72	ko:K04343	-	M00766	R02225	RC00002,RC00078	br01600,ko00000,ko00002,ko01000,ko01504	-	-	-	APH_6_hur
k59_555155_1	1379270.AUXF01000001_gene2097	7.55e-61	197.0	2B33H@1|root,31VR5@2|Bacteria,1ZUG1@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1554945_2	1457250.BBMO01000001_gene1807	4.96e-06	50.4	COG1011@1|root,arCOG02291@2157|Archaea,2XT5H@28890|Euryarchaeota,23V2M@183963|Halobacteria	183963|Halobacteria	S	hydrolase (HAD superfamily)	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
k59_55563_1	1165094.RINTHH_14330	2.84e-51	176.0	COG0484@1|root,COG0484@2|Bacteria,1G0IY@1117|Cyanobacteria,1HJ99@1161|Nostocales	1117|Cyanobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
k59_777667_1	349521.HCH_01319	2.08e-90	288.0	COG1409@1|root,COG1409@2|Bacteria,1N44U@1224|Proteobacteria,1RY17@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	C terminal of Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,MetallophosC,MetallophosN
k59_555227_1	1380391.JIAS01000002_gene3168	3.38e-78	255.0	COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,2TQV8@28211|Alphaproteobacteria,2JQ45@204441|Rhodospirillales	204441|Rhodospirillales	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
k59_777720_1	517418.Ctha_2028	5.65e-19	85.5	COG0735@1|root,COG0735@2|Bacteria,1FE4D@1090|Chlorobi	1090|Chlorobi	K	Belongs to the Fur family	-	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
k59_777720_2	1267534.KB906756_gene621	2.34e-11	62.4	COG0461@1|root,COG0461@2|Bacteria,3Y4ID@57723|Acidobacteria,2JJDT@204432|Acidobacteriia	204432|Acidobacteriia	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
k59_1555083_1	429009.Adeg_1915	1.04e-72	232.0	COG3344@1|root,COG3344@2|Bacteria,1TP9A@1239|Firmicutes,248M4@186801|Clostridia,42EZK@68295|Thermoanaerobacterales	186801|Clostridia	L	PFAM RNA-directed DNA polymerase (Reverse transcriptase)	-	-	2.7.7.49	ko:K00986	-	-	-	-	ko00000,ko01000	-	-	-	GIIM,RVT_1
k59_555286_1	469378.Ccur_01580	4.97e-21	97.1	COG2812@1|root,COG2812@2|Bacteria,2GJKA@201174|Actinobacteria,4CUJ5@84998|Coriobacteriia	84998|Coriobacteriia	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
k59_665798_1	483216.BACEGG_03644	6.71e-05	46.2	COG3119@1|root,COG3119@2|Bacteria,4NHH7@976|Bacteroidetes,2FMAW@200643|Bacteroidia,4AK8N@815|Bacteroidaceae	976|Bacteroidetes	P	COG COG3119 Arylsulfatase A and related enzymes	mdsA	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
k59_665798_2	1267533.KB906733_gene2809	3.21e-11	65.5	COG1472@1|root,COG1472@2|Bacteria,3Y3M7@57723|Acidobacteria,2JMBP@204432|Acidobacteriia	204432|Acidobacteriia	G	Glycosyl hydrolase family 3 C-terminal domain	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
k59_1555108_1	1267535.KB906767_gene3329	7.81e-75	235.0	COG1533@1|root,COG1533@2|Bacteria,3Y2S5@57723|Acidobacteria,2JIC8@204432|Acidobacteriia	204432|Acidobacteriia	L	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
k59_276104_1	1218084.BBJK01000020_gene2126	1.06e-53	178.0	COG1024@1|root,COG1024@2|Bacteria,1Q51H@1224|Proteobacteria,2VIMS@28216|Betaproteobacteria,1K0A8@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	echA15	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
k59_276104_2	1206743.BAGM01000108_gene3394	5.08e-10	56.2	COG2154@1|root,COG2154@2|Bacteria,2IKXR@201174|Actinobacteria,4G30U@85025|Nocardiaceae	201174|Actinobacteria	H	pterin-4-alpha-carbinolamine dehydratase	phhB	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
k59_1555159_1	439235.Dalk_0052	7.65e-74	246.0	COG0531@1|root,COG3064@1|root,COG0531@2|Bacteria,COG3064@2|Bacteria,1R4IZ@1224|Proteobacteria,42MTQ@68525|delta/epsilon subdivisions,2WK39@28221|Deltaproteobacteria,2MIIG@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease,SLC12
k59_609943_1	224325.AF_0438	1.01e-05	49.3	COG0183@1|root,arCOG01278@2157|Archaea,2XT38@28890|Euryarchaeota,245Q6@183980|Archaeoglobi	183980|Archaeoglobi	I	Beta-ketoacyl synthase, N-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_609943_2	1379698.RBG1_1C00001G0906	1.58e-52	172.0	COG1028@1|root,COG1028@2|Bacteria,2NP35@2323|unclassified Bacteria	2|Bacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_777866_1	313628.LNTAR_24818	1.64e-54	184.0	COG3328@1|root,COG3328@2|Bacteria	2|Bacteria	L	transposase activity	tnp	-	-	ko:K07493	-	-	-	-	ko00000	-	-	-	Transposase_mut
k59_555387_1	379066.GAU_1953	1.26e-68	227.0	COG0556@1|root,COG0556@2|Bacteria,1ZSQS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
k59_555389_1	1123355.JHYO01000007_gene477	1.39e-81	251.0	COG1024@1|root,COG1024@2|Bacteria,1MXBB@1224|Proteobacteria,2TU4V@28211|Alphaproteobacteria,36YFA@31993|Methylocystaceae	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
k59_610003_1	1232410.KI421421_gene3657	3.86e-18	82.4	COG2165@1|root,COG2165@2|Bacteria,1N1QJ@1224|Proteobacteria,42TXR@68525|delta/epsilon subdivisions,2WQP0@28221|Deltaproteobacteria,43SPZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	U	Prokaryotic N-terminal methylation motif	-	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl
k59_276210_1	1150626.PHAMO_190062	5.69e-42	149.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,2TRSS@28211|Alphaproteobacteria,2JPYT@204441|Rhodospirillales	204441|Rhodospirillales	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhA	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
k59_1613751_1	926569.ANT_19790	2.18e-24	107.0	COG0210@1|root,COG0210@2|Bacteria,2G86J@200795|Chloroflexi	200795|Chloroflexi	L	UvrD-like helicase C-terminal domain	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_1057858_1	189425.PGRAT_07205	3.89e-05	47.0	COG1492@1|root,COG1492@2|Bacteria,1TP5E@1239|Firmicutes,4HAQW@91061|Bacilli,26UJH@186822|Paenibacillaceae	91061|Bacilli	H	Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation	cobQ	-	6.3.5.10	ko:K02232	ko00860,ko01100,map00860,map01100	M00122	R05225	RC00010,RC01302	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26,CbiA,GATase_3
k59_1057858_2	330214.NIDE2674	6.5e-25	104.0	COG0614@1|root,COG0614@2|Bacteria,3J173@40117|Nitrospirae	40117|Nitrospirae	P	Periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
k59_1724990_1	161156.JQKW01000008_gene508	6.88e-19	84.7	COG2410@1|root,COG2410@2|Bacteria,2GI69@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Protein of unknown function (DUF429)	-	-	-	-	-	-	-	-	-	-	-	-	DUF429
k59_1724990_2	1122921.KB898193_gene2414	4.38e-27	105.0	COG2318@1|root,COG2318@2|Bacteria,1VI69@1239|Firmicutes,4HPG9@91061|Bacilli,26TJI@186822|Paenibacillaceae	91061|Bacilli	S	DinB superfamily	ywlC1	-	-	-	-	-	-	-	-	-	-	-	DinB,DinB_2
k59_557488_1	335284.Pcryo_1208	7.33e-18	79.7	COG1539@1|root,COG1539@2|Bacteria,1MZ8Z@1224|Proteobacteria,1S9B2@1236|Gammaproteobacteria,3NNI7@468|Moraxellaceae	1236|Gammaproteobacteria	H	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin	folB	GO:0003674,GO:0003824,GO:0004150,GO:0005488,GO:0005515,GO:0016829,GO:0016830,GO:0016832,GO:0042802	1.13.11.81,4.1.2.25,5.1.99.8	ko:K01633	ko00790,ko01100,map00790,map01100	M00126,M00840	R03504,R11037,R11073	RC00721,RC00943,RC01479,RC03333,RC03334	ko00000,ko00001,ko00002,ko01000	-	-	iECDH1ME8569_1439.ECDH1ME8569_2955,iECSE_1348.ECSE_3338,iPC815.YPO0648,iSBO_1134.SBO_2914,iSDY_1059.SDY_3241,iSFxv_1172.SFxv_3403,iUTI89_1310.UTI89_C3494,iYL1228.KPN_03462,ic_1306.c3808	FolB
k59_1169095_1	1128427.KB904821_gene2760	9.17e-08	55.1	COG2197@1|root,COG2197@2|Bacteria,1FZXR@1117|Cyanobacteria,1H9GP@1150|Oscillatoriales	1117|Cyanobacteria	KT	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_613119_1	1121403.AUCV01000065_gene4170	1.72e-09	63.9	COG0025@1|root,COG0025@2|Bacteria,1MW5T@1224|Proteobacteria,42M9Y@68525|delta/epsilon subdivisions,2X5IZ@28221|Deltaproteobacteria,2MPF3@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Sodium/hydrogen exchanger family	-	-	-	ko:K03316	-	-	-	-	ko00000	2.A.36	-	-	Na_H_Exchanger
k59_11503_1	330214.NIDE2454	1.8e-96	297.0	COG0114@1|root,COG0114@2|Bacteria,3J0FU@40117|Nitrospirae	40117|Nitrospirae	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	-	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
k59_1512392_1	99598.Cal7507_1962	9.13e-60	205.0	COG0458@1|root,COG0458@2|Bacteria,1G00J@1117|Cyanobacteria,1HJHR@1161|Nostocales	1117|Cyanobacteria	F	PFAM Carbamoyl-phosphate synthase L chain, ATP binding domain	carB	GO:0000050,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_1512392_2	33876.JNXY01000033_gene2181	4.08e-05	43.9	COG1942@1|root,COG1942@2|Bacteria,2IS20@201174|Actinobacteria	201174|Actinobacteria	S	Tautomerase enzyme	-	-	5.3.2.6	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	M00569	R03966,R05389	RC01040,RC01355	ko00000,ko00001,ko00002,ko01000	-	-	-	Tautomerase
k59_734480_1	1254432.SCE1572_49835	5.94e-56	193.0	COG0065@1|root,COG0066@1|root,COG0065@2|Bacteria,COG0066@2|Bacteria,1MVYR@1224|Proteobacteria,42M5D@68525|delta/epsilon subdivisions,2WJ59@28221|Deltaproteobacteria,2YX5D@29|Myxococcales	28221|Deltaproteobacteria	E	Aconitase C-terminal domain	-	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k59_1401183_1	110319.CF8_2011	6.16e-17	76.6	2DRD4@1|root,33B9X@2|Bacteria,2GTDE@201174|Actinobacteria,4DW52@85009|Propionibacteriales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1289917_1	1379270.AUXF01000002_gene1585	8.95e-36	139.0	COG0515@1|root,COG0515@2|Bacteria,1ZUMJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
k59_11515_1	1429916.X566_16000	1.58e-54	199.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VFYM@28211|Alphaproteobacteria,3K6HF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_1123826_1	1123503.KB908059_gene282	7.19e-26	102.0	COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,2TT50@28211|Alphaproteobacteria,2KFSV@204458|Caulobacterales	204458|Caulobacterales	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	1.1.1.31,1.1.1.60	ko:K00020,ko:K00042	ko00280,ko00630,ko01100,map00280,map00630,map01100	-	R01745,R01747,R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
k59_1123826_2	1045855.DSC_06175	2.26e-53	177.0	COG1946@1|root,COG1946@2|Bacteria,1MV9R@1224|Proteobacteria,1RPFI@1236|Gammaproteobacteria,1X38E@135614|Xanthomonadales	135614|Xanthomonadales	I	Acyl-CoA thioesterase	tesB	-	-	ko:K10805	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	4HBT_3
k59_1123838_1	266779.Meso_2282	2.43e-72	241.0	COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,2TTJZ@28211|Alphaproteobacteria,43JFR@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	V	COG0577 ABC-type antimicrobial peptide transport system, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_789938_2	857087.Metme_4338	1.34e-14	74.7	COG0494@1|root,COG0494@2|Bacteria,1RCX7@1224|Proteobacteria,1S3ZE@1236|Gammaproteobacteria,1XEB9@135618|Methylococcales	135618|Methylococcales	L	pfam nudix	-	-	-	ko:K08312	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
k59_1067706_1	1408422.JHYF01000002_gene2492	1.4e-26	112.0	COG0747@1|root,COG0747@2|Bacteria,1TQ0N@1239|Firmicutes,25CDM@186801|Clostridia,36EUU@31979|Clostridiaceae	186801|Clostridia	E	family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_1401219_2	1123368.AUIS01000003_gene1806	1.42e-45	153.0	COG4319@1|root,COG4319@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440,LUD_dom,SnoaL_3,SnoaL_4
k59_289530_1	1238425.J07HQW2_00965	3.76e-45	154.0	COG0819@1|root,arCOG01128@2157|Archaea,2XTG7@28890|Euryarchaeota,23STS@183963|Halobacteria	183963|Halobacteria	K	transcription activator	tenA	-	3.5.99.2	ko:K03707	ko00730,ko01100,map00730,map01100	-	R02133,R09993	RC00224,RC00652,RC02832	ko00000,ko00001,ko01000,ko03000	-	-	-	TENA_THI-4
k59_456395_1	997353.HMPREF9144_0818	5.22e-34	125.0	COG1208@1|root,COG1208@2|Bacteria,4NMJ5@976|Bacteroidetes,2FNEE@200643|Bacteroidia	976|Bacteroidetes	JM	Nucleotidyl transferase	hddC	-	-	-	-	-	-	-	-	-	-	-	NTP_transferase
k59_1345482_1	706587.Desti_1672	1.28e-26	101.0	COG0432@1|root,COG0432@2|Bacteria,1N5SN@1224|Proteobacteria,42SJC@68525|delta/epsilon subdivisions,2WP9F@28221|Deltaproteobacteria,2MRXI@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
k59_956363_2	941639.BCO26_0077	0.000111	48.5	COG1388@1|root,COG3858@1|root,COG1388@2|Bacteria,COG3858@2|Bacteria,1TQK2@1239|Firmicutes,4HBJC@91061|Bacilli,1ZBQC@1386|Bacillus	91061|Bacilli	M	Glycoside Hydrolase Family	yaaH	-	-	ko:K06306	-	-	-	-	ko00000	-	-	-	Glyco_hydro_18,LysM
k59_1457218_1	936136.ARRT01000006_gene2010	1.48e-38	132.0	COG5349@1|root,COG5349@2|Bacteria,1N0WU@1224|Proteobacteria,2UCE7@28211|Alphaproteobacteria,4BEKH@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF983)	-	-	-	-	-	-	-	-	-	-	-	-	DUF983
k59_1457218_2	1538295.JY96_14855	1.88e-35	130.0	COG3346@1|root,COG3346@2|Bacteria,1MWWG@1224|Proteobacteria,2VQAZ@28216|Betaproteobacteria	28216|Betaproteobacteria	S	SURF1-like protein	-	-	-	ko:K14998	-	-	-	-	ko00000,ko03029	3.D.4.8	-	-	SURF1
k59_844942_2	1210884.HG799469_gene14163	1.55e-19	90.5	COG0666@1|root,COG1520@1|root,COG0666@2|Bacteria,COG1520@2|Bacteria,2J2A4@203682|Planctomycetes	203682|Planctomycetes	S	beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
k59_1123878_1	1122138.AQUZ01000003_gene550	8.18e-85	263.0	COG0448@1|root,COG0448@2|Bacteria,2I2EF@201174|Actinobacteria,4DPN8@85009|Propionibacteriales	201174|Actinobacteria	G	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
k59_289555_1	1122611.KB903965_gene4979	4.19e-32	121.0	COG0412@1|root,COG0412@2|Bacteria,2HG49@201174|Actinobacteria,4EKAP@85012|Streptosporangiales	201174|Actinobacteria	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
k59_66890_1	472759.Nhal_0735	1.27e-14	71.6	COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,1S0TV@1236|Gammaproteobacteria,1WXDV@135613|Chromatiales	135613|Chromatiales	K	response regulator receiver	-	-	-	ko:K13041	ko02020,map02020	M00514	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
k59_66890_2	876269.ARWA01000001_gene686	1.78e-25	107.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,3NAFU@45404|Beijerinckiaceae	28211|Alphaproteobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	fixL	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.13.3	ko:K14986	ko02020,map02020	M00524	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,HATPase_c,HisKA,MEDS,PAS,PAS_3,PAS_4,PAS_9
k59_1623173_1	1089544.KB912942_gene3327	4.89e-22	102.0	COG4805@1|root,COG4805@2|Bacteria,2GMUR@201174|Actinobacteria,4DZQU@85010|Pseudonocardiales	201174|Actinobacteria	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
k59_344665_1	861299.J421_2248	6.74e-71	231.0	COG0446@1|root,COG0446@2|Bacteria	2|Bacteria	Q	pyridine nucleotide-disulphide oxidoreductase	-	-	-	ko:K21572	-	-	-	-	ko00000,ko02000	8.A.46.1,8.A.46.3	-	-	SusD-like_3,SusD_RagB
k59_678926_2	306281.AJLK01000183_gene3358	5.04e-35	128.0	COG2323@1|root,COG2323@2|Bacteria,1G5E3@1117|Cyanobacteria,1JJFK@1189|Stigonemataceae	1117|Cyanobacteria	S	Protein of unknown function (DUF421)	-	-	-	-	-	-	-	-	-	-	-	-	DUF421
k59_1178960_1	1123269.NX02_27750	3.42e-11	68.6	COG1680@1|root,COG1680@2|Bacteria,1NHIY@1224|Proteobacteria,2U0A3@28211|Alphaproteobacteria,2K5YI@204457|Sphingomonadales	204457|Sphingomonadales	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_1345514_1	720555.BATR1942_09430	6.25e-17	81.3	COG1595@1|root,COG1595@2|Bacteria,1V4T2@1239|Firmicutes,4HFZ0@91061|Bacilli,1ZEC7@1386|Bacillus	91061|Bacilli	K	Belongs to the sigma-70 factor family. ECF subfamily	sigX	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
k59_1067755_1	1000565.METUNv1_01726	3.12e-43	159.0	COG0419@1|root,COG0419@2|Bacteria,1R4K4@1224|Proteobacteria,2VJVF@28216|Betaproteobacteria,2KW0F@206389|Rhodocyclales	206389|Rhodocyclales	L	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_23
k59_678936_1	1229172.JQFA01000004_gene343	9.97e-30	117.0	COG0797@1|root,COG0797@2|Bacteria,1G0XF@1117|Cyanobacteria,1H985@1150|Oscillatoriales	1117|Cyanobacteria	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	rlpA	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1
k59_11595_1	331678.Cphamn1_2315	3.88e-26	107.0	COG0069@1|root,COG4638@1|root,COG0069@2|Bacteria,COG4638@2|Bacteria,1FDGS@1090|Chlorobi	1090|Chlorobi	C	Belongs to the glutamate synthase family	-	-	-	-	-	-	-	-	-	-	-	-	Glu_synthase,Rieske
k59_344681_1	189753.AXAS01000021_gene1842	5.86e-35	139.0	COG0457@1|root,COG3710@1|root,COG3899@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2U2S9@28211|Alphaproteobacteria,3JX6E@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Trans_reg_C
k59_1178979_1	671143.DAMO_0005	3.07e-67	218.0	COG0612@1|root,COG0612@2|Bacteria,2NP50@2323|unclassified Bacteria	2|Bacteria	S	Insulinase (Peptidase family M16)	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_567142_1	1499967.BAYZ01000028_gene1306	6.83e-77	237.0	COG0559@1|root,COG0559@2|Bacteria,2NP7Z@2323|unclassified Bacteria	2|Bacteria	E	Branched-chain amino acid transport system / permease component	livH	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_122330_1	983920.Y88_3625	7.12e-20	93.6	COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,2TTRU@28211|Alphaproteobacteria,2K1UV@204457|Sphingomonadales	204457|Sphingomonadales	S	Metal-dependent hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_11610_1	1380386.JIAW01000030_gene3590	2.79e-31	127.0	COG1178@1|root,COG1178@2|Bacteria,2GKDH@201174|Actinobacteria,2392Z@1762|Mycobacteriaceae	201174|Actinobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02011,ko:K02063	ko02010,map02010	M00190,M00191	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10,3.A.1.19	-	-	BPD_transp_1,SBP_bac_6
k59_1178993_1	713586.KB900536_gene328	1.46e-37	134.0	COG2133@1|root,COG2133@2|Bacteria,1QWB2@1224|Proteobacteria	1224|Proteobacteria	G	CHRD domain	-	-	-	-	-	-	-	-	-	-	-	-	CHRD
k59_178032_1	1380394.JADL01000002_gene1488	9.21e-79	241.0	COG0220@1|root,COG0220@2|Bacteria,1MUWJ@1224|Proteobacteria,2TUU9@28211|Alphaproteobacteria,2JRSC@204441|Rhodospirillales	204441|Rhodospirillales	J	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	trmB	-	2.1.1.33	ko:K03439	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_4
k59_11627_1	551789.ATVJ01000001_gene2015	2.65e-23	100.0	COG0520@1|root,COG0520@2|Bacteria,1QU0N@1224|Proteobacteria,2TW6K@28211|Alphaproteobacteria,43WBB@69657|Hyphomonadaceae	28211|Alphaproteobacteria	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
k59_11627_2	1380394.JADL01000004_gene5741	4.95e-48	161.0	COG0491@1|root,COG0491@2|Bacteria,1MU8Q@1224|Proteobacteria,2TSVS@28211|Alphaproteobacteria,2JQE0@204441|Rhodospirillales	204441|Rhodospirillales	S	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	gloB	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	HAGH_C,Lactamase_B
k59_678975_1	485913.Krac_9227	1.77e-11	64.3	COG0125@1|root,COG0125@2|Bacteria	2|Bacteria	F	dTDP biosynthetic process	tmk	GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004798,GO:0005488,GO:0005515,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009129,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009161,GO:0009165,GO:0009173,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009218,GO:0009219,GO:0009221,GO:0009259,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0018130,GO:0019001,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0019693,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046044,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046872,GO:0046940,GO:0046983,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.4.9,4.1.1.19	ko:K00943,ko:K01585	ko00240,ko00330,ko01100,map00240,map00330,map01100	M00053,M00133	R00566,R02094,R02098	RC00002,RC00299	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS00680,iJN746.PP_3363,iNJ661.Rv3247c	AAA_33,Thymidylate_kin
k59_678975_2	632292.Calhy_2415	3.22e-39	139.0	COG0125@1|root,COG0125@2|Bacteria,1V07S@1239|Firmicutes,24F7F@186801|Clostridia,42I4T@68295|Thermoanaerobacterales	186801|Clostridia	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	-	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
k59_1734746_1	379066.GAU_1920	1.31e-17	87.0	COG1629@1|root,COG4771@2|Bacteria,1ZST4@142182|Gemmatimonadetes	142182|Gemmatimonadetes	P	CarboxypepD_reg-like domain	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
k59_400676_2	331869.BAL199_23262	4.75e-59	185.0	COG3415@1|root,COG3415@2|Bacteria,1N7CS@1224|Proteobacteria,2UFAY@28211|Alphaproteobacteria,4BR0R@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_32,HTH_33,HTH_Tnp_IS630
k59_567179_1	1042377.AFPJ01000043_gene921	3.23e-24	97.8	COG3090@1|root,COG3090@2|Bacteria,1RJ8K@1224|Proteobacteria,1SA02@1236|Gammaproteobacteria,467GJ@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
k59_567179_2	886379.AEWI01000001_gene1809	9.41e-38	137.0	COG1638@1|root,COG1638@2|Bacteria,4NGV4@976|Bacteroidetes,2FQWN@200643|Bacteroidia,3XJHI@558415|Marinilabiliaceae	976|Bacteroidetes	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_344741_1	765913.ThidrDRAFT_0180	3.43e-25	103.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,1WWT4@135613|Chromatiales	135613|Chromatiales	U	Ammonium transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_344741_2	574966.KB898648_gene682	3.04e-50	161.0	COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,1S67I@1236|Gammaproteobacteria,1XKBF@135619|Oceanospirillales	135619|Oceanospirillales	K	Belongs to the P(II) protein family	-	-	-	ko:K04751,ko:K04752	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
k59_513527_1	1121116.KB894766_gene382	1.52e-18	90.1	COG0491@1|root,COG0491@2|Bacteria,1MVC3@1224|Proteobacteria,2VICE@28216|Betaproteobacteria,4ABG9@80864|Comamonadaceae	28216|Betaproteobacteria	L	PFAM NUDIX hydrolase	-	-	-	ko:K07455	-	-	-	-	ko00000,ko03400	-	-	-	Lactamase_B,NUDIX
k59_1680930_2	1038859.AXAU01000018_gene6728	7.08e-20	88.2	COG1175@1|root,COG1175@2|Bacteria,1MWB7@1224|Proteobacteria,2U6X8@28211|Alphaproteobacteria,3K63F@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
k59_1180692_2	465541.ATCJ01000005_gene4109	0.000891	42.0	COG3585@1|root,COG3585@2|Bacteria,2IKQV@201174|Actinobacteria	201174|Actinobacteria	H	DNA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17,MerR,TOBE
k59_1347303_1	1449068.JMLQ01000003_gene1999	2.45e-35	131.0	COG0052@1|root,COG0052@2|Bacteria,2GMYC@201174|Actinobacteria,4FTWY@85025|Nocardiaceae	201174|Actinobacteria	J	Belongs to the universal ribosomal protein uS2 family	rpsB	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
k59_1347303_2	56780.SYN_03145	2.4e-31	117.0	COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,42NNS@68525|delta/epsilon subdivisions,2WMS3@28221|Deltaproteobacteria,2MRG2@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
k59_1125715_1	1301098.PKB_3909	5.38e-30	118.0	COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,1RN13@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine	mtaD	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
k59_1125715_2	205914.HS_1162	2.14e-20	88.6	COG2227@1|root,COG2227@2|Bacteria,1MU89@1224|Proteobacteria,1RMV7@1236|Gammaproteobacteria,1Y7BY@135625|Pasteurellales	135625|Pasteurellales	H	O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway	ubiG	-	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_23
k59_791839_1	674977.VMC_09370	3.77e-13	74.7	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1XSRH@135623|Vibrionales	135623|Vibrionales	T	signal transduction protein containing a membrane domain, an EAL and a GGDEF domain	-	-	3.1.4.52	ko:K20962	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000	-	-	-	EAL,GGDEF,Response_reg
k59_1014308_1	396588.Tgr7_1815	7.53e-26	101.0	COG0744@1|root,COG0744@2|Bacteria,1RDAQ@1224|Proteobacteria,1RMGB@1236|Gammaproteobacteria,1WWMW@135613|Chromatiales	135613|Chromatiales	M	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors	mtgA	-	2.4.1.129	ko:K03814	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly
k59_1569874_1	1123392.AQWL01000007_gene943	1.29e-15	80.5	COG1821@1|root,COG1821@2|Bacteria,1RBY6@1224|Proteobacteria,2VQ4F@28216|Betaproteobacteria,1KS3K@119069|Hydrogenophilales	119069|Hydrogenophilales	S	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_3
k59_1736451_1	1565129.JSFF01000019_gene1700	3.61e-17	80.5	COG0179@1|root,COG0179@2|Bacteria,1MV0V@1224|Proteobacteria,1RNYV@1236|Gammaproteobacteria,2QA7J@267890|Shewanellaceae	1236|Gammaproteobacteria	Q	PFAM fumarylacetoacetate (FAA) hydrolase	uptA	-	3.7.1.2	ko:K16171	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R01364	RC00326,RC00446	ko00000,ko00001,ko00002,ko01000	-	-	-	FAA_hydrolase
k59_1736451_2	555793.WSK_0848	3.42e-14	75.9	COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,2TSUQ@28211|Alphaproteobacteria,2K0TH@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
k59_1125725_1	159087.Daro_0872	3.15e-81	249.0	COG0777@1|root,COG0777@2|Bacteria,1MW8G@1224|Proteobacteria,2VHEQ@28216|Betaproteobacteria,2KUCF@206389|Rhodocyclales	206389|Rhodocyclales	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	-	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_1291719_1	83406.HDN1F_21290	7.24e-61	201.0	COG0719@1|root,COG0719@2|Bacteria,1MVK0@1224|Proteobacteria,1RP2A@1236|Gammaproteobacteria,1J4N2@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	COG0719 ABC-type transport system involved in Fe-S cluster assembly, permease component	sufD	GO:0006790,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0044085,GO:0044237,GO:0050896,GO:0051186,GO:0071840	-	ko:K09015	-	-	-	-	ko00000	-	-	iB21_1397.B21_01640,iECBD_1354.ECBD_1964,iECB_1328.ECB_01650,iECD_1391.ECD_01650,iUMNK88_1353.UMNK88_2144	UPF0051
k59_846664_1	1122604.JONR01000033_gene45	2.68e-30	124.0	COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,1S0DF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,Guanylate_cyc
k59_1417319_2	1397696.KK211189_gene343	2.3e-26	98.2	COG4895@1|root,COG4895@2|Bacteria,1VEG3@1239|Firmicutes,4HNJA@91061|Bacilli	91061|Bacilli	S	Uncharacterized conserved protein (DUF2196)	ywbE	-	-	-	-	-	-	-	-	-	-	-	DUF2196
k59_695554_1	1231391.AMZF01000001_gene2864	5.56e-30	126.0	COG0577@1|root,COG1136@1|root,COG0577@2|Bacteria,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,2VHZ2@28216|Betaproteobacteria,3T22M@506|Alcaligenaceae	28216|Betaproteobacteria	V	Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides	macB	-	-	ko:K05685	ko02010,map02010	M00709	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.122.1,3.A.1.122.12	-	-	ABC_tran,FtsX,MacB_PCD
k59_27717_1	187272.Mlg_2061	4.28e-52	179.0	COG0477@1|root,COG2814@2|Bacteria,1N2NP@1224|Proteobacteria,1RP1Y@1236|Gammaproteobacteria,1WWDI@135613|Chromatiales	135613|Chromatiales	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1696250_1	472759.Nhal_1853	3.25e-73	234.0	COG0477@1|root,COG2814@2|Bacteria,1MXPM@1224|Proteobacteria,1RNP5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
k59_1750253_1	237368.SCABRO_00954	6.34e-78	249.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_4
k59_1696253_1	1127673.GLIP_3657	3.62e-28	110.0	COG4242@1|root,COG4242@2|Bacteria,1R5TW@1224|Proteobacteria,1RYMR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	PQ	Belongs to the peptidase S51 family	-	-	-	-	-	-	-	-	-	-	-	-	PPC,Peptidase_S51
k59_83277_1	240015.ACP_0853	1.15e-18	91.7	COG1629@1|root,COG3485@1|root,COG3485@2|Bacteria,COG4771@2|Bacteria,3Y36T@57723|Acidobacteria,2JP26@204432|Acidobacteriia	204432|Acidobacteriia	PQ	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
k59_473919_1	1123242.JH636438_gene5826	3.97e-29	118.0	COG0642@1|root,COG2205@2|Bacteria,2IX1S@203682|Planctomycetes	203682|Planctomycetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Ammonium_transp,HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_4,Response_reg
k59_416801_1	1424334.W822_09225	6.41e-09	59.3	COG2175@1|root,COG2175@2|Bacteria,1Q0C7@1224|Proteobacteria,2VQEW@28216|Betaproteobacteria,3T3V5@506|Alcaligenaceae	28216|Betaproteobacteria	Q	Taurine catabolism dioxygenase TauD, TfdA family	-	-	-	-	-	-	-	-	-	-	-	-	TauD
k59_194216_1	1122137.AQXF01000003_gene2220	7.2e-67	216.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,2TQYP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA	kbl	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008144,GO:0016874,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_360782_1	1038859.AXAU01000002_gene255	1.13e-48	172.0	COG1680@1|root,COG1680@2|Bacteria,1MY4Y@1224|Proteobacteria,2TYCG@28211|Alphaproteobacteria,3JTS9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	V	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_1638703_1	314282.PCNPT3_04455	1.16e-31	130.0	COG2304@1|root,COG2931@1|root,COG2304@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,1RNK8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,Cadherin_3,HemolysinCabind,PA14
k59_1084149_1	395494.Galf_2927	1.75e-98	292.0	COG3639@1|root,COG3639@2|Bacteria,1MW4F@1224|Proteobacteria,2VI8W@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Phosphonate ABC transporter	phnE	-	-	ko:K02042	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	BPD_transp_1
k59_1029936_1	402881.Plav_1060	4.4e-96	292.0	COG1960@1|root,COG1960@2|Bacteria,1MVJC@1224|Proteobacteria,2TQRA@28211|Alphaproteobacteria,1JPS7@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	Acyl-CoA dehydrogenase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_1306917_1	1232683.ADIMK_1703	7.37e-48	167.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,1RNAM@1236|Gammaproteobacteria,46AH8@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_1306917_2	1238450.VIBNISOn1_790048	9.11e-11	62.8	COG3090@1|root,COG3090@2|Bacteria,1N0N7@1224|Proteobacteria,1SA1W@1236|Gammaproteobacteria,1Y127@135623|Vibrionales	135623|Vibrionales	G	TRAP-type C4-dicarboxylate transport system, small permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
k59_582850_1	1449080.JQMV01000003_gene1789	6.37e-43	149.0	COG0755@1|root,COG0755@2|Bacteria,1WISW@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	O	ABC-type transport system involved in cytochrome c biogenesis permease component	-	-	-	ko:K02195	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	Cytochrom_C_asm
k59_806090_1	1278073.MYSTI_01655	2.78e-46	172.0	COG0204@1|root,COG1022@1|root,COG3320@1|root,COG0204@2|Bacteria,COG1022@2|Bacteria,COG3320@2|Bacteria,1MU4D@1224|Proteobacteria,42NHQ@68525|delta/epsilon subdivisions,2WJZ5@28221|Deltaproteobacteria,2YU6Q@29|Myxococcales	28221|Deltaproteobacteria	IQ	Male sterility protein	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C,Acyltransferase,NAD_binding_4,PP-binding,Sterile
k59_473993_1	1196323.ALKF01000187_gene5772	2.37e-12	64.3	COG1725@1|root,COG1725@2|Bacteria,1V9ZC@1239|Firmicutes,4HKSY@91061|Bacilli,26XJS@186822|Paenibacillaceae	91061|Bacilli	K	GntR family transcriptional regulator	ytrA_1	-	-	ko:K07979	-	-	-	-	ko00000,ko03000	-	-	-	GntR
k59_473993_2	1122915.AUGY01000153_gene1130	1.14e-17	84.3	COG2208@1|root,COG2208@2|Bacteria,1TQY5@1239|Firmicutes,4HAF6@91061|Bacilli,274E1@186822|Paenibacillaceae	91061|Bacilli	KT	Sigma factor PP2C-like phosphatases	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIE
k59_194274_1	118168.MC7420_6357	4.94e-32	130.0	COG2730@1|root,COG2931@1|root,COG2730@2|Bacteria,COG2931@2|Bacteria,1G314@1117|Cyanobacteria,1HAD6@1150|Oscillatoriales	1117|Cyanobacteria	G	Glycosyl hydrolase family 9	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	CBM_2,Calx-beta,Glyco_hydro_9
k59_1638746_1	1077144.AGFF01000007_gene1686	1.27e-85	263.0	COG1131@1|root,COG1131@2|Bacteria,2GKEH@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
k59_83345_1	1134474.O59_001444	3.46e-39	148.0	COG0515@1|root,COG1262@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria,1T4K6@1236|Gammaproteobacteria,1FGY3@10|Cellvibrio	1236|Gammaproteobacteria	KLT	Sulfatase-modifying factor enzyme 1	ppkA	-	2.7.11.1	ko:K11912	ko02025,ko03070,map02025,map03070	-	-	-	ko00000,ko00001,ko01000,ko01001,ko02044	-	-	-	FGE-sulfatase,PEGA,Pkinase
k59_1638748_1	272568.GDI0121	7.36e-29	117.0	COG0420@1|root,COG0420@2|Bacteria,1MXMJ@1224|Proteobacteria,2TUDV@28211|Alphaproteobacteria,2JSRY@204441|Rhodospirillales	204441|Rhodospirillales	L	Calcineurin-like phosphoesterase	-	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos
k59_1417406_1	765952.PUV_20290	4.15e-21	92.4	COG2267@1|root,COG2267@2|Bacteria,2JG4Y@204428|Chlamydiae	204428|Chlamydiae	I	carboxylic ester hydrolase activity	menH	-	4.2.99.20	ko:K08680	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R08166	RC02148,RC02475	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_6,Hydrolase_4
k59_1584452_1	1122180.Lokhon_02835	0.0008	48.1	COG1538@1|root,COG1538@2|Bacteria,1MWCJ@1224|Proteobacteria,2TR3S@28211|Alphaproteobacteria,2P8J6@245186|Loktanella	28211|Alphaproteobacteria	MU	Outer membrane efflux protein	bepC	-	-	ko:K12340,ko:K12535	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	M00325,M00326,M00327,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	1.B.17,2.A.6.2	-	-	OEP
k59_1195350_2	875328.JDM601_2776	1.21e-22	97.8	COG2114@1|root,COG2267@1|root,COG2114@2|Bacteria,COG2267@2|Bacteria,2IASU@201174|Actinobacteria,232Z7@1762|Mycobacteriaceae	201174|Actinobacteria	IT	PFAM Adenylate and Guanylate cyclase catalytic domain	lipJ	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Guanylate_cyc
k59_27803_1	1123023.JIAI01000001_gene6831	2.07e-52	176.0	COG0662@1|root,COG0662@2|Bacteria,2IA7I@201174|Actinobacteria,4E1GB@85010|Pseudonocardiales	201174|Actinobacteria	G	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1696350_1	391589.RGAI101_430	2.9e-55	194.0	COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2TQP0@28211|Alphaproteobacteria,2P20P@2433|Roseobacter	28211|Alphaproteobacteria	P	COG1123 ATPase components of various ABC-type transport systems, contain duplicated ATPase	gsiA3	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_1750350_1	1306174.JODP01000013_gene7292	4.91e-06	48.1	COG0684@1|root,COG0684@2|Bacteria,2I8VQ@201174|Actinobacteria	201174|Actinobacteria	H	Methyltransferase	ligK	-	4.1.3.17	ko:K10218	ko00362,ko00660,ko01120,map00362,map00660,map01120	-	R00008,R00350	RC00067,RC00502,RC01205	ko00000,ko00001,ko01000	-	-	-	RraA-like
k59_1750350_2	645465.ACUR01000590_gene3460	4.83e-65	205.0	COG2120@1|root,COG2120@2|Bacteria,2GJP3@201174|Actinobacteria	201174|Actinobacteria	S	GlcNAc-PI de-N-acetylase	-	-	4.2.1.83	ko:K16515	ko00362,map00362	-	R04478	RC00498	ko00000,ko00001,ko01000	-	-	-	PIG-L
k59_1084236_1	861299.J421_1255	2.79e-56	179.0	COG3795@1|root,COG3795@2|Bacteria,1ZUYD@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
k59_1084236_2	935567.JAES01000020_gene572	0.000663	41.6	COG4941@1|root,COG4941@2|Bacteria,1MU3D@1224|Proteobacteria,1RN25@1236|Gammaproteobacteria,1X30Y@135614|Xanthomonadales	135614|Xanthomonadales	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_306200_1	1210884.HG799463_gene9521	0.000189	45.1	2DF1X@1|root,2ZQ60@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_973619_1	717785.HYPMC_3777	0.000824	43.5	COG2133@1|root,COG2133@2|Bacteria,1MVK5@1224|Proteobacteria,2TRN9@28211|Alphaproteobacteria,3N6GM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
k59_973619_2	522306.CAP2UW1_4048	4.17e-36	129.0	COG0179@1|root,COG0179@2|Bacteria,1MVFA@1224|Proteobacteria,2VHG8@28216|Betaproteobacteria,1KQKM@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	Q	Fumarylacetoacetate (FAA) hydrolase family	nagK	-	3.7.1.20	ko:K16165	ko00350,ko01100,ko01120,map00350,map01100,map01120	-	R01085	RC00326,RC00446	ko00000,ko00001,ko01000	-	-	-	FAA_hydrolase
k59_1030026_1	1229780.BN381_50144	6.11e-98	317.0	COG0458@1|root,COG0458@2|Bacteria,2GK5N@201174|Actinobacteria,3UW8D@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	F	Carbamoyl-phosphate synthetase large chain, oligomerisation domain	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_695693_1	756272.Plabr_0018	1.93e-75	255.0	COG0178@1|root,COG0178@2|Bacteria,2IXFK@203682|Planctomycetes	203682|Planctomycetes	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	-	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_249753_1	1089453.GOSPT_022_02700	5.98e-11	67.8	COG0596@1|root,COG0596@2|Bacteria,2I2NR@201174|Actinobacteria,4GCQ0@85026|Gordoniaceae	201174|Actinobacteria	S	Alpha/beta hydrolase family	-	-	3.7.1.17	ko:K16050	ko00984,ko01100,ko01120,ko01220,map00984,map01100,map01120,map01220	-	R09883	RC02018,RC02740	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
k59_27839_2	1121447.JONL01000002_gene2149	5.81e-29	116.0	COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,42NC6@68525|delta/epsilon subdivisions,2WJEV@28221|Deltaproteobacteria,2M7Y4@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
k59_1584504_1	1122216.AUHW01000038_gene266	4.35e-37	137.0	COG0083@1|root,COG0083@2|Bacteria,1TRWS@1239|Firmicutes,4H272@909932|Negativicutes	909932|Negativicutes	E	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate	thrB	-	2.7.1.39	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
k59_1696392_1	472175.EL18_00913	2.39e-87	281.0	COG0341@1|root,COG0342@1|root,COG0341@2|Bacteria,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,2TQYG@28211|Alphaproteobacteria,43HFH@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
k59_582938_1	1123371.ATXH01000012_gene1458	6.33e-73	237.0	COG3604@1|root,COG3604@2|Bacteria,2GGRI@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	T	GAF domain	-	-	-	ko:K02584	ko02020,map02020	-	-	-	ko00000,ko00001,ko03000	-	-	-	GAF,GAF_2,HTH_8,Sigma54_activat
k59_1473744_1	329726.AM1_6085	1.85e-50	181.0	COG2909@1|root,COG2909@2|Bacteria,1G3UH@1117|Cyanobacteria	1117|Cyanobacteria	K	ATP-dependent transcriptional regulator	-	-	-	ko:K03556	-	-	-	-	ko00000,ko03000	-	-	-	GerE
k59_1252598_1	485916.Dtox_4318	2.68e-83	262.0	COG0174@1|root,COG0174@2|Bacteria,1TNZA@1239|Firmicutes,2489S@186801|Clostridia,264Q7@186807|Peptococcaceae	186801|Clostridia	E	Glutamine synthetase, catalytic domain	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
k59_806181_1	319795.Dgeo_1304	5.32e-40	146.0	COG0166@1|root,COG0166@2|Bacteria,1WIGN@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	Belongs to the GPI family	pgi	-	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
k59_806181_2	1220582.RRU01S_07_04520	2.91e-17	80.5	COG1023@1|root,COG1023@2|Bacteria,1QU14@1224|Proteobacteria,2TT6S@28211|Alphaproteobacteria,4B8FR@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	6-phosphogluconate dehydrogenase	gnd	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
k59_1473773_1	1120956.JHZK01000025_gene2012	3.69e-06	52.0	COG3637@1|root,COG3637@2|Bacteria,1RGBR@1224|Proteobacteria,2VAKH@28211|Alphaproteobacteria,1JQ7X@119043|Rhodobiaceae	28211|Alphaproteobacteria	M	OmpA-like transmembrane domain	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl
k59_973692_1	290397.Adeh_2550	1.33e-42	159.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,42M6W@68525|delta/epsilon subdivisions,2WIZF@28221|Deltaproteobacteria,2YUFJ@29|Myxococcales	28221|Deltaproteobacteria	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
k59_138411_1	944480.ATUV01000001_gene1248	2.55e-83	257.0	COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,42M8G@68525|delta/epsilon subdivisions,2WIYB@28221|Deltaproteobacteria,2M6YX@213113|Desulfurellales	28221|Deltaproteobacteria	CE	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
k59_475135_1	1392502.JNIO01000008_gene1934	4.79e-05	51.6	COG0578@1|root,COG0578@2|Bacteria,1TQJN@1239|Firmicutes,4H2I3@909932|Negativicutes	909932|Negativicutes	C	PFAM FAD dependent oxidoreductase	glpA	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,Fer2_BFD
k59_1751357_1	996637.SGM_3958	1.07e-65	217.0	COG4122@1|root,COG4122@2|Bacteria,2GJGI@201174|Actinobacteria	201174|Actinobacteria	S	proteasome accessory factor PafA2	dop	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006464,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0016810,GO:0016811,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0051603,GO:0070490,GO:0070647,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	3.5.1.119	ko:K20814	-	-	-	-	ko00000,ko01000,ko03051	-	-	-	Pup_ligase
k59_1474762_1	247633.GP2143_11237	2.5e-66	209.0	COG4221@1|root,COG4221@2|Bacteria,1QTXD@1224|Proteobacteria,1T1MG@1236|Gammaproteobacteria,1J8AB@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_920194_1	768671.ThimaDRAFT_0896	6.6e-36	132.0	COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,1RMFQ@1236|Gammaproteobacteria,1WX4T@135613|Chromatiales	135613|Chromatiales	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GTP1_OBG,MMR_HSR1
k59_920194_2	1155714.KB891987_gene3143	2.32e-05	47.0	COG0599@1|root,COG0599@2|Bacteria	2|Bacteria	S	peroxiredoxin activity	-	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD
k59_1418424_1	316274.Haur_3201	4.07e-41	145.0	COG0451@1|root,COG0451@2|Bacteria	2|Bacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase,NAD_binding_10
k59_751428_1	102107.XP_008244248.1	2.88e-31	125.0	COG0492@1|root,COG0526@1|root,KOG0404@2759|Eukaryota,KOG0907@2759|Eukaryota,37IAU@33090|Viridiplantae,3GAAM@35493|Streptophyta,4JGSC@91835|fabids	35493|Streptophyta	O	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	-	GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006109,GO:0008047,GO:0008150,GO:0008152,GO:0009056,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009636,GO:0009889,GO:0009987,GO:0010380,GO:0010556,GO:0010581,GO:0010675,GO:0010962,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0016999,GO:0017001,GO:0017144,GO:0019222,GO:0019725,GO:0030234,GO:0031323,GO:0031326,GO:0032881,GO:0032885,GO:0042221,GO:0042592,GO:0042737,GO:0042743,GO:0042744,GO:0042802,GO:0043085,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043255,GO:0044093,GO:0044237,GO:0044248,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0045454,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051171,GO:0051186,GO:0051187,GO:0051193,GO:0051716,GO:0055114,GO:0060255,GO:0065007,GO:0065008,GO:0065009,GO:0070887,GO:0072593,GO:0080090,GO:0090056,GO:0097237,GO:0098754,GO:0098772,GO:0098869,GO:1901401,GO:1901463,GO:1990748,GO:2000112,GO:2000904	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Thioredoxin
k59_417989_1	1439940.BAY1663_00847	9.94e-06	45.4	COG0346@1|root,COG0346@2|Bacteria,1RJR7@1224|Proteobacteria,1S71Y@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Lactoylglutathione lyase and related lyases	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
k59_417989_2	1122135.KB893157_gene397	1.08e-68	217.0	COG1703@1|root,COG1703@2|Bacteria,1MVI0@1224|Proteobacteria,2TS96@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	periplasmic protein kinase ArgK and related GTPases of G3E family	argK	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
k59_195383_1	381666.H16_B1406	1.89e-43	147.0	COG0702@1|root,COG0702@2|Bacteria,1MYVU@1224|Proteobacteria,2VHXZ@28216|Betaproteobacteria,1K36U@119060|Burkholderiaceae	28216|Betaproteobacteria	GM	NmrA family	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10,NmrA
k59_1639821_1	1231391.AMZF01000003_gene3115	2.73e-55	180.0	COG1028@1|root,COG1028@2|Bacteria,1N3A2@1224|Proteobacteria,2W95G@28216|Betaproteobacteria,3T7RQ@506|Alcaligenaceae	28216|Betaproteobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_1363304_1	1121403.AUCV01000056_gene3022	6.93e-89	270.0	COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,42N2V@68525|delta/epsilon subdivisions,2WIPS@28221|Deltaproteobacteria,2MIPC@213118|Desulfobacterales	28221|Deltaproteobacteria	O	HflC and HflK could regulate a protease	hflC	-	-	ko:K04087	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
k59_28864_1	388051.AUFE01000034_gene3649	1.08e-08	53.9	COG0251@1|root,COG0251@2|Bacteria,1RB9R@1224|Proteobacteria,2VRZG@28216|Betaproteobacteria,1K81G@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
k59_28864_2	7719.XP_004225568.2	1.65e-15	78.2	2CDB0@1|root,2S5FA@2759|Eukaryota,38DQQ@33154|Opisthokonta,3BH0H@33208|Metazoa,3CSSQ@33213|Bilateria,485TW@7711|Chordata	33208|Metazoa	C	thyroxine 5-deiodinase activity	DIO3	GO:0001654,GO:0001754,GO:0003407,GO:0003674,GO:0003824,GO:0004800,GO:0005575,GO:0005623,GO:0005886,GO:0006575,GO:0006590,GO:0006725,GO:0006807,GO:0006915,GO:0007275,GO:0007399,GO:0007423,GO:0008150,GO:0008152,GO:0008219,GO:0009056,GO:0009653,GO:0009887,GO:0009987,GO:0010721,GO:0010817,GO:0012501,GO:0016020,GO:0016491,GO:0018958,GO:0019336,GO:0019439,GO:0022008,GO:0022603,GO:0030154,GO:0030182,GO:0032501,GO:0032502,GO:0033798,GO:0040008,GO:0040014,GO:0040018,GO:0042219,GO:0042403,GO:0042404,GO:0042445,GO:0042447,GO:0042461,GO:0042462,GO:0042478,GO:0042480,GO:0042670,GO:0043010,GO:0044237,GO:0044248,GO:0044464,GO:0045595,GO:0045596,GO:0045664,GO:0045665,GO:0045927,GO:0046530,GO:0046532,GO:0046533,GO:0046549,GO:0048468,GO:0048513,GO:0048518,GO:0048519,GO:0048523,GO:0048592,GO:0048593,GO:0048638,GO:0048639,GO:0048666,GO:0048699,GO:0048731,GO:0048856,GO:0048869,GO:0050767,GO:0050768,GO:0050789,GO:0050793,GO:0050794,GO:0051093,GO:0051094,GO:0051239,GO:0051240,GO:0051241,GO:0051402,GO:0051960,GO:0051961,GO:0055114,GO:0060041,GO:0060042,GO:0060219,GO:0060284,GO:0065007,GO:0065008,GO:0070997,GO:0071704,GO:0071944,GO:0090596,GO:0097474,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901615,GO:1901616,GO:1990009,GO:2000026,GO:2000027	1.21.99.3,1.21.99.4	ko:K01562,ko:K07754	ko04919,map04919	-	-	-	ko00000,ko00001,ko01000	-	-	-	T4_deiodinase
k59_920207_1	1347086.CCBA010000027_gene3528	6.64e-25	104.0	COG4962@1|root,COG4962@2|Bacteria,1TQ0Z@1239|Firmicutes,4HAQM@91061|Bacilli,1ZBDR@1386|Bacillus	91061|Bacilli	U	COG4962 Flp pilus assembly protein, ATPase CpaF	cpaF	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
k59_529207_1	642492.Clole_3786	1.34e-41	147.0	COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,247IP@186801|Clostridia	186801|Clostridia	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_139334_1	237368.SCABRO_00506	3.09e-94	290.0	COG1690@1|root,COG1690@2|Bacteria,2IWY4@203682|Planctomycetes	203682|Planctomycetes	S	Belongs to the RtcB family	rtcB	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
k59_861400_1	1299327.I546_2236	2.43e-48	171.0	COG5421@1|root,COG5421@2|Bacteria,2IEYR@201174|Actinobacteria	201174|Actinobacteria	L	Domain of unknown function (DUF4277)	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4277
k59_807186_1	391625.PPSIR1_25986	2.32e-40	150.0	COG1866@1|root,COG1866@2|Bacteria	2|Bacteria	H	phosphoenolpyruvate carboxykinase (ATP) activity	pckA	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004611,GO:0004612,GO:0005488,GO:0005509,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016829,GO:0016830,GO:0016831,GO:0017076,GO:0019318,GO:0019319,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046872,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901576	4.1.1.49	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00170	R00341	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_3169,iSB619.SA_RS09060,iSF_1195.SF3422,iUTI89_1310.UTI89_C3903,iYO844.BSU30560	PEPCK_ATP
k59_1363334_1	4896.SPAC637.05c.1	6.98e-45	160.0	COG1156@1|root,KOG1351@2759|Eukaryota,38F6K@33154|Opisthokonta,3NWY5@4751|Fungi,3QK93@4890|Ascomycota,3MBNI@451866|Taphrinomycotina	4751|Fungi	C	V-type ATPase V1 subunit B	VMA2	GO:0000221,GO:0000322,GO:0000323,GO:0000324,GO:0000329,GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005773,GO:0005774,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006873,GO:0006874,GO:0006875,GO:0006885,GO:0006914,GO:0007035,GO:0008150,GO:0008152,GO:0008324,GO:0009056,GO:0009405,GO:0009987,GO:0010494,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015988,GO:0015991,GO:0016020,GO:0016021,GO:0016043,GO:0016462,GO:0016469,GO:0016471,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019725,GO:0019829,GO:0022607,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030003,GO:0030004,GO:0030641,GO:0031090,GO:0031224,GO:0032991,GO:0033176,GO:0033178,GO:0033180,GO:0034220,GO:0034622,GO:0035770,GO:0036442,GO:0036464,GO:0042592,GO:0042623,GO:0042625,GO:0042626,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043248,GO:0043492,GO:0043933,GO:0044085,GO:0044232,GO:0044237,GO:0044248,GO:0044419,GO:0044422,GO:0044424,GO:0044425,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0044769,GO:0045851,GO:0046961,GO:0048878,GO:0050801,GO:0051179,GO:0051234,GO:0051452,GO:0051453,GO:0051704,GO:0055065,GO:0055067,GO:0055074,GO:0055080,GO:0055082,GO:0055085,GO:0061919,GO:0065003,GO:0065007,GO:0065008,GO:0071840,GO:0071944,GO:0072503,GO:0072507,GO:0090662,GO:0098588,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:0098796,GO:0098805,GO:0098852,GO:0099131,GO:0099132,GO:1902600,GO:1902906,GO:1990816,GO:1990904	-	ko:K02147	ko00190,ko01100,ko04145,ko04150,ko04721,ko04966,ko05110,ko05120,ko05323,map00190,map01100,map04145,map04150,map04721,map04966,map05110,map05120,map05323	M00160	-	-	ko00000,ko00001,ko00002,ko04147	3.A.2.2	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_1639853_1	930166.CD58_11765	7.92e-42	155.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1T1IW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GAF_2,GGDEF,HTH_8,Sigma54_activat,V4R,XylR_N
k59_639371_1	1231392.OCGS_2825	4.86e-83	254.0	COG2030@1|root,COG2030@2|Bacteria,1MUR2@1224|Proteobacteria,2TUM7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydrat_N,MaoC_dehydratas
k59_153247_1	9646.ENSAMEP00000003498	4.68e-43	153.0	COG1028@1|root,KOG1208@2759|Eukaryota,38CZD@33154|Opisthokonta,3BACQ@33208|Metazoa,3CSEJ@33213|Bilateria,4883Z@7711|Chordata,4917U@7742|Vertebrata,3J8YR@40674|Mammalia,3EK3C@33554|Carnivora	33208|Metazoa	Q	Retinol dehydrogenase 13	RDH13	GO:0001523,GO:0001654,GO:0001754,GO:0003407,GO:0003674,GO:0003824,GO:0004033,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006066,GO:0006629,GO:0006720,GO:0006721,GO:0007275,GO:0007399,GO:0007423,GO:0008106,GO:0008150,GO:0008152,GO:0009314,GO:0009416,GO:0009628,GO:0009642,GO:0009644,GO:0009653,GO:0009887,GO:0009987,GO:0010817,GO:0010842,GO:0016020,GO:0016101,GO:0016491,GO:0016614,GO:0016616,GO:0019866,GO:0022008,GO:0030154,GO:0030182,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032501,GO:0032502,GO:0034308,GO:0034754,GO:0042445,GO:0042461,GO:0042462,GO:0042572,GO:0043010,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046530,GO:0048468,GO:0048513,GO:0048592,GO:0048593,GO:0048646,GO:0048666,GO:0048699,GO:0048731,GO:0048856,GO:0048869,GO:0050896,GO:0052650,GO:0055114,GO:0060041,GO:0060042,GO:0065007,GO:0065008,GO:0071704,GO:0090596,GO:1901615	1.1.1.300,2.3.2.27	ko:K04506,ko:K11152,ko:K11153,ko:K11161	ko00830,ko01100,ko04013,ko04115,ko04120,ko04310,map00830,map01100,map04013,map04115,map04120,map04310	-	R08379,R08380,R08383	RC00649	ko00000,ko00001,ko01000,ko04121	-	-	-	adh_short
k59_652118_1	1192034.CAP_0448	3.43e-44	168.0	COG0457@1|root,COG0515@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,42NXT@68525|delta/epsilon subdivisions,2WIZ3@28221|Deltaproteobacteria,2YU18@29|Myxococcales	28221|Deltaproteobacteria	KLT	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Guanylate_cyc,Pkinase
k59_153261_1	1123024.AUII01000006_gene4635	4.76e-58	193.0	2DN8B@1|root,32W2U@2|Bacteria,2ISPU@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1210006_1	1122223.KB890697_gene1079	1.36e-30	125.0	COG2199@1|root,COG3903@1|root,COG3706@2|Bacteria,COG3903@2|Bacteria	2|Bacteria	K	ADP binding	-	-	2.7.11.1	ko:K08282	-	-	-	-	ko00000,ko01000	-	-	-	AAA_22,BTAD,GGDEF,Guanylate_cyc,NB-ARC,Pkinase,TPR_12,Trans_reg_C
k59_597708_1	1205680.CAKO01000040_gene939	1.44e-32	129.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TW3C@28211|Alphaproteobacteria,2JQPB@204441|Rhodospirillales	204441|Rhodospirillales	IQ	AMP-binding enzyme	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding
k59_597709_1	1463854.JOHT01000001_gene2651	3.64e-32	128.0	COG0146@1|root,COG0146@2|Bacteria,2HWA8@201174|Actinobacteria	201174|Actinobacteria	EQ	PFAM Hydantoinase B oxoprolinase	-	-	-	-	-	-	-	-	-	-	-	-	Hydantoinase_B
k59_876105_1	1246484.D479_09200	2.34e-57	181.0	COG0096@1|root,COG0096@2|Bacteria,1V3KK@1239|Firmicutes,4HH32@91061|Bacilli,3NERQ@45667|Halobacillus	91061|Bacilli	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
k59_1377871_1	751944.HALDL1_14330	7e-47	169.0	COG0421@1|root,arCOG00050@2157|Archaea,2XUEJ@28890|Euryarchaeota,23T1E@183963|Halobacteria	183963|Halobacteria	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	speE	-	-	-	-	-	-	-	-	-	-	-	Spermine_synth
k59_1432563_1	65093.PCC7418_0299	2.06e-31	127.0	COG0659@1|root,COG0664@1|root,COG0659@2|Bacteria,COG0664@2|Bacteria,1G3AY@1117|Cyanobacteria	1117|Cyanobacteria	P	COGs COG0659 Sulfate permease and related transporter (MFS superfamily)	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp,cNMP_binding
k59_711204_1	357808.RoseRS_3055	1.89e-72	227.0	COG1172@1|root,COG1172@2|Bacteria,2G8TB@200795|Chloroflexi	200795|Chloroflexi	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
k59_1542418_1	526227.Mesil_3344	1.56e-38	147.0	COG5295@1|root,COG5295@2|Bacteria	2|Bacteria	UW	Hep Hag repeat protein	yeeJ	-	-	ko:K21449	-	-	-	-	ko00000,ko02000	1.B.40.2	-	-	DUF5122,Peptidase_S74,YadA_head,YadA_stalk
k59_153311_1	1038859.AXAU01000015_gene986	2.99e-56	190.0	COG1960@1|root,COG1960@2|Bacteria,1MXMQ@1224|Proteobacteria,2TTF6@28211|Alphaproteobacteria,3JV1J@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.14.14.12,1.14.14.27	ko:K16047,ko:K20942	ko00362,ko00984,ko01100,ko01120,map00362,map00984,map01100,map01120	-	R09819,R11348	RC00046,RC00236	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_2,Acyl-CoA_dh_N
k59_376411_1	861299.J421_3346	1.11e-56	192.0	COG4799@1|root,COG4799@2|Bacteria,1ZTGB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Carboxyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
k59_711215_1	518766.Rmar_0629	2.97e-32	130.0	COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria,4NERT@976|Bacteroidetes,1FJ3R@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	MU	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	BSP,Bac_surface_Ag,PD40
k59_98339_1	1122599.AUGR01000002_gene3357	2.34e-61	201.0	COG4948@1|root,COG4948@2|Bacteria,1MYZE@1224|Proteobacteria,1RYFV@1236|Gammaproteobacteria,1XR9A@135619|Oceanospirillales	135619|Oceanospirillales	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	5.1.2.2	ko:K01781	ko00627,ko01120,map00627,map01120	-	R03791,R04161	RC00998	ko00000,ko00001,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
k59_1432579_2	448385.sce4838	5.56e-41	142.0	COG3253@1|root,COG3253@2|Bacteria	2|Bacteria	S	peroxidase activity	ywfI	-	-	ko:K00435	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R11522	RC00884	ko00000,ko00001,ko01000	-	-	-	Chlor_dismutase
k59_711222_1	644282.Deba_0559	4.41e-17	83.2	COG1775@1|root,COG1775@2|Bacteria,1NKED@1224|Proteobacteria,42NFZ@68525|delta/epsilon subdivisions,2WMBX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM 2-hydroxyglutaryl-CoA dehydratase, D-component	-	-	-	-	-	-	-	-	-	-	-	-	HGD-D
k59_711222_2	1121447.JONL01000005_gene1643	1.84e-31	119.0	COG1924@1|root,COG1924@2|Bacteria,1R6HU@1224|Proteobacteria,42RWX@68525|delta/epsilon subdivisions,2WNC9@28221|Deltaproteobacteria,2MGTF@213115|Desulfovibrionales	28221|Deltaproteobacteria	I	BadF/BadG/BcrA/BcrD ATPase family	yjiL	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
k59_1323194_1	211165.AJLN01000149_gene6648	1.27e-41	156.0	COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria,1JJA2@1189|Stigonemataceae	1117|Cyanobacteria	Q	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,TauD,Thioesterase
k59_41788_1	313595.P700755_000763	5.64e-05	52.0	COG1629@1|root,COG4771@2|Bacteria,4NDX3@976|Bacteroidetes,1HY9Q@117743|Flavobacteriia,4C4ED@83612|Psychroflexus	976|Bacteroidetes	P	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
k59_98349_1	344747.PM8797T_27954	2.32e-37	141.0	COG4974@1|root,COG4974@2|Bacteria	2|Bacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,PRiA4_ORF3,zf-IS66
k59_98349_2	398525.KB900701_gene457	7.06e-14	69.7	COG3436@1|root,COG3436@2|Bacteria,1N0VT@1224|Proteobacteria,2USZ3@28211|Alphaproteobacteria,3K4CT@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	IS66 Orf2 like protein	-	-	-	-	-	-	-	-	-	-	-	-	TnpB_IS66
k59_431664_1	163908.KB235896_gene4878	5.05e-52	179.0	COG3385@1|root,COG3385@2|Bacteria,1G2T1@1117|Cyanobacteria,1HMX0@1161|Nostocales	1117|Cyanobacteria	L	PFAM Transposase DDE domain	-	-	-	ko:K07495	-	-	-	-	ko00000	-	-	-	DDE_5,DDE_Tnp_1
k59_711237_1	886293.Sinac_1231	1.02e-36	140.0	COG3464@1|root,COG3464@2|Bacteria,2J4EX@203682|Planctomycetes	203682|Planctomycetes	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1323209_1	861299.J421_3571	7.81e-97	312.0	COG0458@1|root,COG0458@2|Bacteria,1ZSPK@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Carbamoyl-phosphate synthetase large chain, oligomerisation domain	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_1268516_2	485913.Krac_2347	1.73e-50	175.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,2G8EF@200795|Chloroflexi	2|Bacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_28,HTH_29,HTH_32,HTH_33
k59_322229_1	195250.CM001776_gene2309	4.84e-45	155.0	COG4122@1|root,COG4122@2|Bacteria,1G4MU@1117|Cyanobacteria,1H1TI@1129|Synechococcus	1117|Cyanobacteria	M	Macrocin-O-methyltransferase (TylF)	-	-	-	ko:K05303	-	-	-	-	ko00000,ko01000	-	-	-	Glycos_transf_2,Methyltransf_23,Methyltransf_24,TylF
k59_322229_2	1074488.AGBX01000001_gene1007	1.85e-32	120.0	COG0384@1|root,COG0384@2|Bacteria,2GM1W@201174|Actinobacteria,4FDJA@85020|Dermabacteraceae	201174|Actinobacteria	S	Phenazine biosynthesis-like protein	phzF	-	-	-	-	-	-	-	-	-	-	-	PhzC-PhzF
k59_207538_1	862751.SACTE_0168	2.54e-05	48.5	COG2197@1|root,COG2197@2|Bacteria,2GM61@201174|Actinobacteria	201174|Actinobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_711249_1	861299.J421_0144	4.3e-94	289.0	COG1004@1|root,COG1004@2|Bacteria,1ZTH3@142182|Gemmatimonadetes	2|Bacteria	M	UDP binding domain	ugd	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
k59_989632_1	1168289.AJKI01000001_gene3626	6.12e-07	56.2	COG5002@1|root,COG5002@2|Bacteria,4PKV1@976|Bacteroidetes,2G0ES@200643|Bacteroidia	976|Bacteroidetes	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_9,Response_reg
k59_876160_1	1168065.DOK_18800	3.92e-58	192.0	COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,1RNIR@1236|Gammaproteobacteria,1J5D9@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
k59_711259_1	1191523.MROS_0711	1.12e-72	233.0	COG0493@1|root,COG0493@2|Bacteria	2|Bacteria	C	'glutamate synthase	gltD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	iJN678.gltD,iNJ661.Rv3858c,iSB619.SA_RS02450	Fer4_20,Pyr_redox_2
k59_489471_1	981384.AEYW01000006_gene2901	5.34e-09	59.3	COG3852@1|root,COG3852@2|Bacteria,1MVN6@1224|Proteobacteria,2TQS1@28211|Alphaproteobacteria,4NBP5@97050|Ruegeria	28211|Alphaproteobacteria	T	Nitrogen regulation protein	ntrB	-	2.7.13.3	ko:K07708	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_4
k59_489471_2	264732.Moth_2131	1.79e-10	63.5	COG2206@1|root,COG2206@2|Bacteria,1V6WM@1239|Firmicutes,24FPG@186801|Clostridia,42J9V@68295|Thermoanaerobacterales	186801|Clostridia	T	HDOD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD,HD_5
k59_1045908_1	266265.Bxe_A3278	3.42e-56	179.0	COG3865@1|root,COG3865@2|Bacteria,1N7IY@1224|Proteobacteria,2VSAQ@28216|Betaproteobacteria,1KGYN@119060|Burkholderiaceae	28216|Betaproteobacteria	H	3-Demethylubiquinone-9 3-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	3-dmu-9_3-mt
k59_711261_1	999549.KI421514_gene319	2.85e-11	67.4	COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,2TQQ4@28211|Alphaproteobacteria,2810S@191028|Leisingera	28211|Alphaproteobacteria	J	Anticodon binding domain	proS	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b
k59_322258_1	379066.GAU_1124	1.88e-51	174.0	COG0484@1|root,COG0484@2|Bacteria,1ZT5T@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	-	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
k59_153381_1	1120950.KB892750_gene6877	1.71e-15	79.0	COG0005@1|root,COG0005@2|Bacteria,2GKGG@201174|Actinobacteria,4DMZ7@85009|Propionibacteriales	201174|Actinobacteria	F	Phosphorylase superfamily	mtnP	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
k59_1155404_1	760568.Desku_1546	6.47e-24	106.0	COG3276@1|root,COG3276@2|Bacteria,1TPQS@1239|Firmicutes,2484U@186801|Clostridia,260IK@186807|Peptococcaceae	186801|Clostridia	J	Elongation factor Tu domain 2	selB	-	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3
k59_376478_1	1242864.D187_005262	3.25e-52	175.0	COG1409@1|root,COG1409@2|Bacteria,1RJ6Z@1224|Proteobacteria	1224|Proteobacteria	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
k59_937561_1	316274.Haur_3782	1.41e-51	177.0	COG0520@1|root,COG0520@2|Bacteria,2G7N0@200795|Chloroflexi,377HP@32061|Chloroflexia	32061|Chloroflexia	H	PFAM aminotransferase class V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
k59_209505_1	7955.ENSDARP00000115860	0.000683	47.4	COG0664@1|root,KOG1113@2759|Eukaryota,38GS1@33154|Opisthokonta,3BESA@33208|Metazoa,3CWK8@33213|Bilateria	33208|Metazoa	T	Camp-dependent protein kinase type	PRKAR2A	GO:0000166,GO:0000902,GO:0000904,GO:0001664,GO:0001674,GO:0001932,GO:0001933,GO:0001934,GO:0003008,GO:0003014,GO:0003091,GO:0003674,GO:0004857,GO:0004860,GO:0004862,GO:0005102,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005813,GO:0005815,GO:0005829,GO:0005856,GO:0005886,GO:0005929,GO:0005952,GO:0006469,GO:0006928,GO:0006935,GO:0006950,GO:0007154,GO:0007165,GO:0007275,GO:0007399,GO:0007409,GO:0007411,GO:0007596,GO:0007599,GO:0007610,GO:0007622,GO:0007623,GO:0007626,GO:0008150,GO:0008603,GO:0009410,GO:0009605,GO:0009611,GO:0009636,GO:0009653,GO:0009719,GO:0009725,GO:0009892,GO:0009893,GO:0009987,GO:0010033,GO:0010243,GO:0010562,GO:0010563,GO:0010564,GO:0010604,GO:0010605,GO:0010720,GO:0014070,GO:0015630,GO:0016020,GO:0016043,GO:0017076,GO:0019207,GO:0019210,GO:0019220,GO:0019222,GO:0019887,GO:0019899,GO:0019900,GO:0019901,GO:0019904,GO:0022008,GO:0022607,GO:0023052,GO:0030030,GO:0030104,GO:0030154,GO:0030182,GO:0030234,GO:0030291,GO:0030315,GO:0030534,GO:0030551,GO:0030552,GO:0030554,GO:0031175,GO:0031323,GO:0031324,GO:0031325,GO:0031399,GO:0031400,GO:0031401,GO:0031588,GO:0031625,GO:0031690,GO:0031698,GO:0032147,GO:0032268,GO:0032269,GO:0032270,GO:0032501,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0032870,GO:0032989,GO:0032990,GO:0032991,GO:0033673,GO:0033674,GO:0033762,GO:0034199,GO:0034236,GO:0035556,GO:0036094,GO:0040011,GO:0042060,GO:0042220,GO:0042221,GO:0042325,GO:0042326,GO:0042327,GO:0042330,GO:0042383,GO:0042493,GO:0042585,GO:0042592,GO:0042802,GO:0042803,GO:0042995,GO:0043073,GO:0043085,GO:0043086,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043279,GO:0043434,GO:0043549,GO:0043900,GO:0043902,GO:0043933,GO:0044085,GO:0044092,GO:0044093,GO:0044389,GO:0044422,GO:0044424,GO:0044425,GO:0044430,GO:0044441,GO:0044444,GO:0044446,GO:0044459,GO:0044463,GO:0044464,GO:0044853,GO:0045121,GO:0045471,GO:0045475,GO:0045595,GO:0045597,GO:0045787,GO:0045859,GO:0045860,GO:0045936,GO:0045937,GO:0046677,GO:0046983,GO:0048148,GO:0048149,GO:0048468,GO:0048471,GO:0048511,GO:0048512,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048666,GO:0048667,GO:0048699,GO:0048731,GO:0048812,GO:0048856,GO:0048858,GO:0048869,GO:0048871,GO:0048878,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050817,GO:0050878,GO:0050891,GO:0050896,GO:0051018,GO:0051094,GO:0051171,GO:0051172,GO:0051173,GO:0051174,GO:0051239,GO:0051240,GO:0051246,GO:0051247,GO:0051248,GO:0051259,GO:0051291,GO:0051338,GO:0051347,GO:0051348,GO:0051445,GO:0051446,GO:0051716,GO:0051726,GO:0060255,GO:0060281,GO:0060282,GO:0060284,GO:0060359,GO:0061564,GO:0061695,GO:0065003,GO:0065007,GO:0065008,GO:0065009,GO:0070887,GO:0071310,GO:0071375,GO:0071377,GO:0071417,GO:0071495,GO:0071840,GO:0071900,GO:0071901,GO:0071944,GO:0072347,GO:0080090,GO:0090068,GO:0097159,GO:0097305,GO:0097332,GO:0097338,GO:0097367,GO:0097485,GO:0097546,GO:0098589,GO:0098590,GO:0098772,GO:0098805,GO:0098857,GO:0120025,GO:0120036,GO:0120038,GO:0120039,GO:1900193,GO:1900195,GO:1901265,GO:1901363,GO:1901652,GO:1901653,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902494,GO:1902911,GO:1903429,GO:1903431,GO:1903538,GO:1904146,GO:1905879,GO:1905881,GO:1990234,GO:2000241,GO:2000243,GO:2000479,GO:2000480	-	ko:K04739	ko04910,map04910	-	-	-	ko00000,ko00001	-	-	-	RIIa,cNMP_binding
k59_100533_2	1396858.Q666_04055	5.81e-92	274.0	COG1177@1|root,COG1177@2|Bacteria,1MVC5@1224|Proteobacteria,1RQB7@1236|Gammaproteobacteria,46461@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	COG1177 ABC-type spermidine putrescine transport system, permease component II	potC	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0008519,GO:0015075,GO:0015101,GO:0015203,GO:0015399,GO:0015405,GO:0015417,GO:0015595,GO:0015606,GO:0015695,GO:0015696,GO:0015846,GO:0015847,GO:0015848,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0042623,GO:0042626,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072488,GO:0098533,GO:0098655,GO:0098796,GO:0098797,GO:1902047,GO:1902494,GO:1902495,GO:1903711,GO:1904949,GO:1990351	-	ko:K11070	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	iSBO_1134.SBO_1939	BPD_transp_1
k59_878425_1	671143.DAMO_2062	7.86e-81	258.0	COG0498@1|root,COG0498@2|Bacteria,2NP42@2323|unclassified Bacteria	2|Bacteria	E	Threonine synthase	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	LeuA_dimer,PALP
k59_1325432_1	1380394.JADL01000016_gene462	5.02e-39	136.0	COG0824@1|root,COG0824@2|Bacteria,1MZB3@1224|Proteobacteria,2U7CU@28211|Alphaproteobacteria,2JUFI@204441|Rhodospirillales	204441|Rhodospirillales	S	Thioesterase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT_2
k59_1047770_1	522306.CAP2UW1_2826	1.56e-94	299.0	COG0398@1|root,COG1249@1|root,COG0398@2|Bacteria,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2VH3T@28216|Betaproteobacteria,1KQAC@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	C	SNARE associated Golgi protein	merA	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim,SNARE_assoc
k59_766805_1	1137269.AZWL01000012_gene3017	1.53e-23	98.6	COG4315@1|root,COG4315@2|Bacteria,2GNDV@201174|Actinobacteria	201174|Actinobacteria	S	Secreted repeat of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	Lipoprotein_15
k59_1101878_1	543632.JOJL01000024_gene2045	1.5e-41	157.0	COG0068@1|root,COG0298@1|root,COG0068@2|Bacteria,COG0298@2|Bacteria,2GJYF@201174|Actinobacteria,4DID7@85008|Micromonosporales	201174|Actinobacteria	O	Acylphosphatase	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
k59_766806_1	379066.GAU_1686	6.48e-68	222.0	COG0305@1|root,COG0305@2|Bacteria,1ZSMZ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Participates in initiation and elongation during chromosome replication	-	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
k59_1714410_1	1177928.TH2_06946	5.03e-50	169.0	COG0583@1|root,COG0583@2|Bacteria,1MV36@1224|Proteobacteria,2TVHU@28211|Alphaproteobacteria,2JWHN@204441|Rhodospirillales	204441|Rhodospirillales	K	COG0583 Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_1714410_2	224911.27350588	5.48e-07	51.2	COG3485@1|root,COG3485@2|Bacteria,1MUYX@1224|Proteobacteria,2TU2C@28211|Alphaproteobacteria,3JVVZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Protocatechuate 3,4-dioxygenase beta subunit N terminal	pcaH	-	1.13.11.3	ko:K00449	ko00362,ko00624,ko01100,ko01120,ko01220,map00362,map00624,map01100,map01120,map01220	-	R01631,R03549	RC00388,RC00953	br01602,ko00000,ko00001,ko01000	-	-	-	Dioxygenase_C,PCDO_beta_N
k59_599792_1	95619.PM1_0219815	1.46e-06	50.8	COG2199@1|root,COG3706@2|Bacteria	2|Bacteria	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,dCache_1
k59_265702_2	1379270.AUXF01000001_gene2303	1.48e-14	75.5	COG2304@1|root,COG5426@1|root,COG2304@2|Bacteria,COG5426@2|Bacteria,1ZUB1@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Putative glutamine amidotransferase	-	-	-	-	-	-	-	-	-	-	-	-	GATase1_like
k59_545102_1	1382304.JNIL01000001_gene3229	1.47e-36	136.0	COG2025@1|root,COG2025@2|Bacteria,1TPC8@1239|Firmicutes,4HAE2@91061|Bacilli,27893@186823|Alicyclobacillaceae	91061|Bacilli	C	Electron transfer flavoprotein FAD-binding domain	etfA	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006091,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009055,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0019395,GO:0019752,GO:0022900,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901575	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
k59_1434782_1	756499.Desde_3781	1.06e-65	216.0	COG0849@1|root,COG0849@2|Bacteria,1TQC5@1239|Firmicutes,24BFJ@186801|Clostridia,2605E@186807|Peptococcaceae	186801|Clostridia	D	TIGRFAM conserved	mutL2	-	-	-	-	-	-	-	-	-	-	-	MutL
k59_492113_1	760192.Halhy_3405	1.12e-69	224.0	COG0381@1|root,COG0381@2|Bacteria,4NGBD@976|Bacteroidetes,1IR9A@117747|Sphingobacteriia	976|Bacteroidetes	M	Belongs to the UDP-N-acetylglucosamine 2-epimerase family	wecB	-	5.1.3.14,5.1.3.23	ko:K01791,ko:K13019	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420,R09600	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase_2
k59_1544491_1	543632.JOJL01000024_gene1979	2.36e-05	49.7	COG5637@1|root,COG5637@2|Bacteria,2I3U7@201174|Actinobacteria,4DMM4@85008|Micromonosporales	201174|Actinobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
k59_1602039_1	1453501.JELR01000002_gene577	3.39e-18	84.0	COG0683@1|root,COG0683@2|Bacteria,1MU8V@1224|Proteobacteria,1RMIJ@1236|Gammaproteobacteria,4654K@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component	urtA	-	-	ko:K11959	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	Peripla_BP_5
k59_545112_1	1196031.ALEG01000041_gene2677	5.05e-16	78.2	COG1959@1|root,COG1959@2|Bacteria,1V6FG@1239|Firmicutes,4HMA4@91061|Bacilli,1ZF97@1386|Bacillus	91061|Bacilli	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
k59_1325470_1	472759.Nhal_2137	2.83e-72	229.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,1RMUD@1236|Gammaproteobacteria,1WWH3@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	-	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
k59_492138_1	404589.Anae109_1894	1.42e-39	145.0	COG0674@1|root,COG0674@2|Bacteria,1NBSJ@1224|Proteobacteria,42MS1@68525|delta/epsilon subdivisions,2WJ97@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
k59_766835_1	1218075.BAYA01000052_gene6846	1.45e-112	339.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2VK9J@28216|Betaproteobacteria,1K4IS@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Product type h extrachromosomal origin	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
k59_937630_1	477974.Daud_0851	2.24e-48	176.0	COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,1TP53@1239|Firmicutes,247XR@186801|Clostridia,264Z9@186807|Peptococcaceae	186801|Clostridia	G	Alpha-amylase domain	ams	-	2.4.1.4,3.2.1.1,5.4.99.16	ko:K05341,ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R01823,R02108,R02112,R11262	RC00028,RC01816	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase
k59_1625876_1	1198232.CYCME_1005	1.06e-84	261.0	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,1RNHY@1236|Gammaproteobacteria,45ZTV@72273|Thiotrichales	72273|Thiotrichales	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
k59_625348_1	379066.GAU_0711	1.08e-64	207.0	COG1127@1|root,COG1127@2|Bacteria,1ZT5N@142182|Gemmatimonadetes	142182|Gemmatimonadetes	Q	ABC transporter	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
k59_1404167_1	880073.Calab_1223	7.45e-58	194.0	COG2079@1|root,COG2079@2|Bacteria,2NREN@2323|unclassified Bacteria	2|Bacteria	S	MmgE/PrpD family	prpD	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009268,GO:0009628,GO:0009987,GO:0010447,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017001,GO:0017144,GO:0019541,GO:0019543,GO:0019626,GO:0019629,GO:0019679,GO:0019752,GO:0030312,GO:0032787,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046459,GO:0047547,GO:0050896,GO:0071704,GO:0071944,GO:0072329,GO:1901575	4.2.1.79	ko:K01720	ko00640,map00640	-	R04424	RC01152	ko00000,ko00001,ko01000	-	-	-	MmgE_PrpD
k59_904366_1	443152.MDG893_15040	1.05e-32	127.0	COG2423@1|root,COG2423@2|Bacteria,1N3EI@1224|Proteobacteria	1224|Proteobacteria	E	ornithine cyclodeaminase	-	-	4.3.1.12	ko:K01750	ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230	-	R00671	RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
k59_292434_1	469378.Ccur_07940	1.04e-10	69.7	COG0365@1|root,COG0365@2|Bacteria,2GJSQ@201174|Actinobacteria,4CUM0@84998|Coriobacteriia	84998|Coriobacteriia	I	AMP-binding enzyme C-terminal domain	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_124870_1	196367.JNFG01000199_gene3708	5.41e-07	53.1	COG4964@1|root,COG4964@2|Bacteria,1MV8G@1224|Proteobacteria,2VIVD@28216|Betaproteobacteria,1JZXV@119060|Burkholderiaceae	28216|Betaproteobacteria	U	Belongs to the GSP D family	-	-	-	ko:K02280	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Secretin,T2SS-T3SS_pil_N
k59_1238622_2	1122137.AQXF01000006_gene806	2.97e-20	91.7	COG0189@1|root,COG0189@2|Bacteria,1MV29@1224|Proteobacteria,2U88X@28211|Alphaproteobacteria	28211|Alphaproteobacteria	HJ	COG0189 Glutathione synthase Ribosomal protein S6 modification enzyme (glutaminyl transferase)	-	-	-	-	-	-	-	-	-	-	-	-	GSH-S_ATP
k59_1015376_1	1453501.JELR01000001_gene2897	6.99e-23	100.0	COG2010@1|root,COG2010@2|Bacteria,1MVYK@1224|Proteobacteria,1RQH2@1236|Gammaproteobacteria,465QC@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_236891_1	926569.ANT_25700	4.9e-101	326.0	COG0265@1|root,COG0642@1|root,COG2203@1|root,COG0265@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,2G7SE@200795|Chloroflexi	200795|Chloroflexi	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA
k59_236896_1	1449076.JOOE01000003_gene3761	3.11e-28	118.0	COG5360@1|root,COG5360@2|Bacteria,1MUJ4@1224|Proteobacteria,2TR5G@28211|Alphaproteobacteria,2K1RQ@204457|Sphingomonadales	204457|Sphingomonadales	S	Heparinase	-	-	-	-	-	-	-	-	-	-	-	-	Hepar_II_III
k59_1737561_1	62928.azo3706	1.48e-57	188.0	COG0500@1|root,COG0500@2|Bacteria,1N3PV@1224|Proteobacteria,2VK53@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	Putative methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
k59_682022_1	1120948.KB903218_gene1855	2.72e-40	150.0	COG0365@1|root,COG0365@2|Bacteria,2GJVK@201174|Actinobacteria,4E0VD@85010|Pseudonocardiales	201174|Actinobacteria	I	AMP-binding enzyme C-terminal domain	badA	-	6.2.1.25,6.2.1.50	ko:K04110,ko:K12424	ko00362,ko00627,ko01100,ko01120,map00362,map00627,map01100,map01120	-	R01422,R11608,R11872,R11873	RC00004,RC00174	ko00000,ko00001,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_1238640_1	522306.CAP2UW1_1452	2.4e-62	202.0	28J8Y@1|root,2Z943@2|Bacteria,1REXC@1224|Proteobacteria,2W0TK@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Domain of unknown function (DUF4338)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4338
k59_625399_1	1122176.KB903565_gene3388	1.56e-15	75.5	COG0224@1|root,COG0224@2|Bacteria,4NECM@976|Bacteroidetes,1IQEQ@117747|Sphingobacteriia	976|Bacteroidetes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
k59_625399_2	932678.THERU_05560	3.53e-22	95.9	COG0056@1|root,COG0056@2|Bacteria,2G3IZ@200783|Aquificae	200783|Aquificae	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
k59_459620_1	861299.J421_3971	8.93e-64	218.0	COG0550@1|root,COG0550@2|Bacteria,1ZTA9@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
k59_14490_1	931627.MycrhDRAFT_3414	2.92e-06	56.2	COG0515@1|root,COG3903@1|root,COG0515@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,233DM@1762|Mycobacteriaceae	201174|Actinobacteria	K	involved in signal transduction (via phosphorylation) involved in transcriptional regulatory mechanism and in the regulation of secondary metabolites catalytic activity ATP a protein ADP a phosphoprotein	pknK_2	-	-	-	-	-	-	-	-	-	-	-	AAA_22,GerE,NB-ARC,Pkinase,TPR_12
k59_1292745_1	929712.KI912613_gene4372	3.9e-67	228.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2GJY2@201174|Actinobacteria,4CP7C@84995|Rubrobacteria	84995|Rubrobacteria	L	DNA polymerase	-	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A
k59_792915_1	1131269.AQVV01000004_gene599	2.66e-27	112.0	COG3225@1|root,COG3225@2|Bacteria	2|Bacteria	-	-	gldG	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC_transp_aux
k59_792915_2	880072.Desac_0031	1.32e-32	121.0	COG1277@1|root,COG1277@2|Bacteria,1NZZ9@1224|Proteobacteria,42SH9@68525|delta/epsilon subdivisions,2WPWW@28221|Deltaproteobacteria,2MRMI@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_3,ABC_transp_aux
k59_1625945_1	1216007.AOPM01000114_gene199	2.06e-32	115.0	COG3695@1|root,COG3695@2|Bacteria,1N7J2@1224|Proteobacteria,1SCIZ@1236|Gammaproteobacteria,2Q3D9@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	L	methylated DNA-protein cysteine methyltransferase	ybaZ	GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0005488,GO:0005515,GO:0019899,GO:0097159,GO:1901363	-	ko:K07443	-	-	-	-	ko00000	-	-	-	DNA_binding_1
k59_1625945_2	1137799.GZ78_04215	2.46e-13	70.5	COG2271@1|root,COG2271@2|Bacteria,1QUF4@1224|Proteobacteria,1RPSF@1236|Gammaproteobacteria,1XRU0@135619|Oceanospirillales	135619|Oceanospirillales	G	COG0477 Permeases of the major facilitator superfamily	-	-	-	ko:K08218	ko01501,map01501	M00628	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.25	-	-	Acatn,MFS_1
k59_180783_1	1162668.LFE_0771	3.26e-16	80.9	COG2204@1|root,COG2204@2|Bacteria,3J0YM@40117|Nitrospirae	40117|Nitrospirae	T	Bacterial regulatory protein, Fis family	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1238685_2	580340.Tlie_1575	5.28e-57	187.0	COG1180@1|root,COG1180@2|Bacteria,3T9PA@508458|Synergistetes	508458|Synergistetes	C	TIGRFAM glycyl-radical enzyme activating protein family	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4,Fer4_12,Radical_SAM
k59_292514_1	28532.XP_010536637.1	2.79e-106	323.0	COG0137@1|root,KOG1706@2759|Eukaryota,37QUX@33090|Viridiplantae,3G8Y6@35493|Streptophyta,3HYQY@3699|Brassicales	35493|Streptophyta	E	argininosuccinate synthase	-	GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
k59_792943_1	706587.Desti_1075	1.74e-82	270.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k59_292516_1	1177179.A11A3_09155	1.71e-50	176.0	COG0671@1|root,COG0671@2|Bacteria,1RF6B@1224|Proteobacteria,1SC5U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	COG0671 Membrane-associated phospholipid phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	PAP2_3
k59_569872_1	1089547.KB913013_gene2706	1.07e-31	124.0	COG1960@1|root,COG1960@2|Bacteria,4NFD4@976|Bacteroidetes,47NH5@768503|Cytophagia	976|Bacteroidetes	I	Acyl-CoA dehydrogenase, middle domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_124959_1	223184.AS25_08120	2.36e-44	159.0	COG0151@1|root,COG0151@2|Bacteria,2I2F5@201174|Actinobacteria,1W832@1268|Micrococcaceae	201174|Actinobacteria	F	Belongs to the GARS family	purD	GO:0008150,GO:0040007	6.3.3.1,6.3.4.13	ko:K01945,ko:K11788	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144,R04208	RC00090,RC00166,RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
k59_847711_1	667632.KB890220_gene2766	1.87e-17	85.1	COG0438@1|root,COG0438@2|Bacteria,1MVA7@1224|Proteobacteria,2VM0Z@28216|Betaproteobacteria,1K0MP@119060|Burkholderiaceae	28216|Betaproteobacteria	M	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
k59_1070583_1	266117.Rxyl_0336	1.02e-07	52.4	COG3391@1|root,COG3391@2|Bacteria,2I9U0@201174|Actinobacteria,4CSKA@84995|Rubrobacteria	84995|Rubrobacteria	S	56kDa selenium binding protein (SBP56)	-	-	-	ko:K17285	-	-	-	-	ko00000,ko04147	-	-	-	SBP56
k59_1070583_2	266117.Rxyl_0337	2.03e-48	161.0	2AI77@1|root,318MJ@2|Bacteria,2IG4V@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1348493_2	404589.Anae109_4238	1.33e-46	152.0	COG2030@1|root,COG2030@2|Bacteria,1RJN8@1224|Proteobacteria	1224|Proteobacteria	I	dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
k59_569900_1	1101190.ARWB01000001_gene3136	5.57e-42	144.0	COG0431@1|root,COG0431@2|Bacteria,1MXQ8@1224|Proteobacteria,2TRI5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	NAD(P)H-dependent FMN reductase	MA20_28735	-	-	-	-	-	-	-	-	-	-	-	FMN_red
k59_1460186_1	935557.ATYB01000008_gene5433	7.89e-42	157.0	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2TQY9@28211|Alphaproteobacteria,4BAMI@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	transporter	-	-	-	-	-	-	-	-	-	-	-	-	DUF3394,DctM
k59_1515379_1	926550.CLDAP_22960	7.07e-65	224.0	COG2909@1|root,COG3629@1|root,COG2909@2|Bacteria,COG3629@2|Bacteria,2G7WA@200795|Chloroflexi	200795|Chloroflexi	K	intracellular signal transduction	-	-	-	-	-	-	-	-	-	-	-	-	BTAD
k59_904523_1	518766.Rmar_1428	7.01e-57	199.0	COG3063@1|root,COG3063@2|Bacteria	2|Bacteria	NU	photosynthesis	-	-	2.7.11.1	ko:K12132,ko:K20543	-	-	-	-	ko00000,ko01000,ko01001,ko02000	1.B.55.3	-	-	AAA_16,NfrA_C,Pkinase,TPR_10,TPR_12,TPR_14,TPR_16,TPR_19,TPR_8
k59_292553_1	525368.HMPREF0591_4367	7.75e-69	240.0	COG3039@1|root,COG3039@2|Bacteria,2HW75@201174|Actinobacteria,237RJ@1762|Mycobacteriaceae	201174|Actinobacteria	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_793001_1	207954.MED92_07936	7.29e-79	254.0	COG0304@1|root,COG0304@2|Bacteria,1MV67@1224|Proteobacteria,1RMXJ@1236|Gammaproteobacteria,1XHM8@135619|Oceanospirillales	135619|Oceanospirillales	IQ	Belongs to the beta-ketoacyl-ACP synthases family	-	-	2.3.1.180	ko:K18473	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_292555_1	290398.Csal_3094	5.25e-112	340.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,1RMDD@1236|Gammaproteobacteria,1XI2A@135619|Oceanospirillales	135619|Oceanospirillales	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
k59_514835_2	1122622.ATWJ01000007_gene1610	4.67e-65	209.0	COG0714@1|root,COG0714@2|Bacteria,2GK07@201174|Actinobacteria,4FEQS@85021|Intrasporangiaceae	201174|Actinobacteria	S	ATPase family associated with various cellular activities (AAA)	moxR2	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
k59_1460220_1	1207063.P24_01956	3.55e-103	313.0	COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,2TQXH@28211|Alphaproteobacteria,2JQXD@204441|Rhodospirillales	204441|Rhodospirillales	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
k59_237049_2	523791.Kkor_0194	6.72e-34	119.0	COG3070@1|root,COG3070@2|Bacteria,1N0ND@1224|Proteobacteria,1SE8F@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Regulator of competence-specific genes	-	-	-	-	-	-	-	-	-	-	-	-	TfoX_N
k59_14607_1	640510.BC1001_3616	6.24e-43	150.0	COG1801@1|root,COG1801@2|Bacteria,1MU7F@1224|Proteobacteria,2VIFI@28216|Betaproteobacteria,1K07U@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
k59_69888_1	289376.THEYE_A0930	1.89e-34	130.0	COG0774@1|root,COG0774@2|Bacteria,3J0JG@40117|Nitrospirae	40117|Nitrospirae	M	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis	lpxC	-	3.5.1.108	ko:K02535	ko00540,ko01100,map00540,map01100	M00060	R04587	RC00166,RC00300	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxC
k59_1682159_1	1382356.JQMP01000004_gene241	1.33e-07	52.4	2A4RG@1|root,30TCV@2|Bacteria,2GA1J@200795|Chloroflexi,27YN3@189775|Thermomicrobia	189775|Thermomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1682159_2	671143.DAMO_1586	1.41e-38	136.0	COG3088@1|root,COG3088@2|Bacteria,2NRBD@2323|unclassified Bacteria	2|Bacteria	P	subunit of a heme lyase	ccmH	-	-	ko:K02198,ko:K02200	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmH
k59_959473_1	986075.CathTA2_2530	9.7e-78	241.0	COG0090@1|root,COG0090@2|Bacteria,1TP9X@1239|Firmicutes,4HAE8@91061|Bacilli	91061|Bacilli	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
k59_1460232_1	292459.STH1774	4.4e-09	63.2	COG0260@1|root,COG0260@2|Bacteria,1TPJZ@1239|Firmicutes,248KF@186801|Clostridia	186801|Clostridia	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
k59_682192_1	861299.J421_0266	3.16e-22	95.9	COG5012@1|root,COG5012@2|Bacteria,1ZV9T@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding
k59_180887_1	224911.27350923	1.29e-33	129.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2TTXG@28211|Alphaproteobacteria,3JVJZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_237059_1	926569.ANT_15830	5.9e-43	149.0	COG1087@1|root,COG1087@2|Bacteria,2GA96@200795|Chloroflexi	200795|Chloroflexi	M	3-beta hydroxysteroid dehydrogenase/isomerase family	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
k59_237059_2	926569.ANT_19980	1.22e-39	143.0	COG1086@1|root,COG2148@1|root,COG1086@2|Bacteria,COG2148@2|Bacteria,2G67F@200795|Chloroflexi	200795|Chloroflexi	M	PFAM sugar transferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
k59_569955_1	1869.MB27_33105	1.97e-31	117.0	COG5433@1|root,COG5433@2|Bacteria,2HYBN@201174|Actinobacteria,4DD18@85008|Micromonosporales	201174|Actinobacteria	L	required for the transposition of insertion element IS2404	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
k59_569955_2	380394.Lferr_2797	1.17e-10	63.2	COG5433@1|root,COG5433@2|Bacteria,1RAHU@1224|Proteobacteria,1S1TZ@1236|Gammaproteobacteria,2NDWK@225057|Acidithiobacillales	1236|Gammaproteobacteria	L	DDE_Tnp_1-associated	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc,DUF4338
k59_1070651_1	1201290.M902_2388	1.38e-57	198.0	COG0189@1|root,COG0189@2|Bacteria,1MX5X@1224|Proteobacteria,42MPG@68525|delta/epsilon subdivisions,2WKW8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	HJ	RimK-like ATPgrasp N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Dala_Dala_lig_C,RLAN,RimK
k59_514883_1	1122622.ATWJ01000010_gene1431	4.24e-48	162.0	2F548@1|root,33XRC@2|Bacteria,2H5BG@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_403609_1	344747.PM8797T_03935	5.4e-55	194.0	COG0457@1|root,COG0457@2|Bacteria,2IXP3@203682|Planctomycetes	203682|Planctomycetes	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,TPR_16
k59_1737739_1	1150469.RSPPHO_00357	5.74e-65	210.0	COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,2TQKG@28211|Alphaproteobacteria,2JPCN@204441|Rhodospirillales	204441|Rhodospirillales	CE	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
k59_1571102_1	483219.LILAB_26000	5.13e-83	259.0	COG2801@1|root,COG2801@2|Bacteria,1PBHA@1224|Proteobacteria,42MUE@68525|delta/epsilon subdivisions,2WJFZ@28221|Deltaproteobacteria,2YTXG@29|Myxococcales	28221|Deltaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	rve
k59_459801_1	439235.Dalk_0260	3.78e-08	58.9	COG0789@1|root,COG0789@2|Bacteria,1N7M7@1224|Proteobacteria,42WAT@68525|delta/epsilon subdivisions,2WRPH@28221|Deltaproteobacteria,2MMFX@213118|Desulfobacterales	28221|Deltaproteobacteria	K	PFAM regulatory protein MerR	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
k59_69924_1	309801.trd_1930	3.89e-167	489.0	COG0366@1|root,COG0366@2|Bacteria,2G89J@200795|Chloroflexi,27XYW@189775|Thermomicrobia	189775|Thermomicrobia	G	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB	glgE	-	2.4.99.16	ko:K16147	ko00500,ko01100,map00500,map01100	-	R09994	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3416
k59_1348589_1	1121939.L861_17285	1.6e-107	323.0	COG0277@1|root,COG0277@2|Bacteria,1MUPW@1224|Proteobacteria,1RRDD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	FAD linked oxidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
k59_1070686_2	5147.XP_003345039.1	1.4e-09	60.5	COG0580@1|root,KOG0223@2759|Eukaryota,398Y2@33154|Opisthokonta,3NV37@4751|Fungi,3QNEU@4890|Ascomycota,214DM@147550|Sordariomycetes,3U7N1@5139|Sordariales,3UFXV@5148|Sordariaceae	4751|Fungi	P	Belongs to the MIP aquaporin (TC 1.A.8) family	AQY1	GO:0000003,GO:0003006,GO:0003674,GO:0005215,GO:0005372,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006833,GO:0007049,GO:0008150,GO:0009653,GO:0009987,GO:0012505,GO:0015250,GO:0015267,GO:0015318,GO:0016020,GO:0016021,GO:0019953,GO:0022402,GO:0022413,GO:0022414,GO:0022803,GO:0022838,GO:0022857,GO:0030154,GO:0030435,GO:0030437,GO:0031224,GO:0031226,GO:0031984,GO:0032502,GO:0032505,GO:0034220,GO:0034293,GO:0042044,GO:0042175,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043934,GO:0043935,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044459,GO:0044464,GO:0044703,GO:0048468,GO:0048646,GO:0048856,GO:0048869,GO:0051179,GO:0051234,GO:0051321,GO:0051704,GO:0055085,GO:0071944,GO:0098827,GO:1903046	-	ko:K09885	-	-	-	-	ko00000,ko02000	1.A.8	-	-	MIP
k59_906510_1	671143.DAMO_0611	2.44e-75	241.0	COG1216@1|root,COG1216@2|Bacteria,2NRAF@2323|unclassified Bacteria	2|Bacteria	S	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	GT87
k59_16558_1	477974.Daud_0851	2.36e-187	558.0	COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,1TP53@1239|Firmicutes,247XR@186801|Clostridia,264Z9@186807|Peptococcaceae	186801|Clostridia	G	Alpha-amylase domain	ams	-	2.4.1.4,3.2.1.1,5.4.99.16	ko:K05341,ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R01823,R02108,R02112,R11262	RC00028,RC01816	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase
k59_849589_1	477641.MODMU_2527	1.84e-84	258.0	COG0500@1|root,COG2226@2|Bacteria,2GNXF@201174|Actinobacteria	201174|Actinobacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
k59_516827_1	28444.JODQ01000001_gene2375	2.01e-106	323.0	COG1653@1|root,COG1653@2|Bacteria,2I9M7@201174|Actinobacteria,4EQ61@85012|Streptosporangiales	201174|Actinobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K10117	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	SBP_bac_1,SBP_bac_8
k59_71770_1	525897.Dbac_1840	2.9e-44	158.0	COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,42TI5@68525|delta/epsilon subdivisions,2WQR8@28221|Deltaproteobacteria,2MG9C@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
k59_849593_1	1128421.JAGA01000002_gene785	2.12e-68	223.0	COG1003@1|root,COG1003@2|Bacteria,2NNSG@2323|unclassified Bacteria	2|Bacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	GO:0001505,GO:0003674,GO:0003824,GO:0004375,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016491,GO:0016638,GO:0016642,GO:0017144,GO:0019464,GO:0019752,GO:0032991,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902494,GO:1990204	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS11880	Aminotran_5,GDC-P
k59_461797_1	1123389.ATXJ01000006_gene2253	6.97e-10	65.1	COG0411@1|root,COG4177@1|root,COG0411@2|Bacteria,COG4177@2|Bacteria,1WI0Z@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01995,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C,BPD_transp_2
k59_193701_1	1122919.KB905549_gene2090	2.54e-79	250.0	COG0281@1|root,COG0281@2|Bacteria,1TPJ3@1239|Firmicutes,4H9WR@91061|Bacilli,26QD2@186822|Paenibacillaceae	91061|Bacilli	C	Malic enzyme	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	Malic_M,malic
k59_1416881_1	1123368.AUIS01000021_gene987	1.42e-38	139.0	COG0725@1|root,COG0725@2|Bacteria,1NACV@1224|Proteobacteria,1T2QW@1236|Gammaproteobacteria,2ND9P@225057|Acidithiobacillales	225057|Acidithiobacillales	P	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_11
k59_1583903_1	1283300.ATXB01000001_gene1268	4.82e-91	287.0	COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,1RP6F@1236|Gammaproteobacteria,1XDJH@135618|Methylococcales	135618|Methylococcales	G	Belongs to the glycosyl hydrolase 13 family	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,CBM_48
k59_973020_1	134676.ACPL_3072	1.98e-27	115.0	COG0514@1|root,COG0514@2|Bacteria,2GJSS@201174|Actinobacteria,4D9ZJ@85008|Micromonosporales	201174|Actinobacteria	L	DNA helicase	recQ	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,Helicase_C,RQC,RecQ_Zn_bind
k59_637773_1	1144310.PMI07_005437	2.77e-55	181.0	COG0235@1|root,COG0235@2|Bacteria,1RB5Z@1224|Proteobacteria,2U0PK@28211|Alphaproteobacteria,4BJMH@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Class II Aldolase and Adducin N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II
k59_1638245_1	388413.ALPR1_14459	9.73e-80	256.0	COG0308@1|root,COG0308@2|Bacteria,4NE13@976|Bacteroidetes,47K4C@768503|Cytophagia	976|Bacteroidetes	E	Peptidase family M1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
k59_1749845_1	1459636.NTE_02809	1.8e-99	301.0	COG1915@1|root,arCOG04422@2157|Archaea,41SBQ@651137|Thaumarchaeota	651137|Thaumarchaeota	S	LOR SDH bifunctional	-	-	-	-	-	-	-	-	-	-	-	-	Saccharop_dh_N
k59_1194819_1	187272.Mlg_1646	3.61e-96	300.0	COG2225@1|root,COG2225@2|Bacteria,1MVEV@1224|Proteobacteria,1RPVI@1236|Gammaproteobacteria,1WXV7@135613|Chromatiales	135613|Chromatiales	C	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA	glcB	-	2.3.3.9	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472	RC00004,RC00308,RC02747	ko00000,ko00001,ko00002,ko01000	-	-	-	Malate_synthase
k59_1473153_1	714943.Mucpa_2155	4.74e-19	94.7	COG0577@1|root,COG0577@2|Bacteria,4NDUK@976|Bacteroidetes,1INWS@117747|Sphingobacteriia	976|Bacteroidetes	V	InterPro IPR003838	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_416373_1	1128421.JAGA01000002_gene1417	1.94e-35	129.0	COG2178@1|root,COG2178@2|Bacteria,2NR1U@2323|unclassified Bacteria	2|Bacteria	J	PFAM Translin	-	-	-	ko:K07477	-	-	-	-	ko00000	-	-	-	-
k59_1252021_1	1283283.ATXA01000005_gene2208	7.12e-79	243.0	COG4974@1|root,COG4974@2|Bacteria,2ID5W@201174|Actinobacteria,4EWWQ@85013|Frankiales	201174|Actinobacteria	L	Phage integrase, N-terminal SAM-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_1638256_2	323259.Mhun_2065	1.07e-12	67.8	COG1233@1|root,arCOG01521@2157|Archaea,2Y1KE@28890|Euryarchaeota	28890|Euryarchaeota	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
k59_637790_1	1038859.AXAU01000012_gene4355	1.39e-47	170.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,2TQTG@28211|Alphaproteobacteria,3JUU3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	B12 binding domain	metH	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_637790_2	395019.Bmul_1049	1.08e-29	113.0	COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,2VHCD@28216|Betaproteobacteria,1K20D@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Belongs to the GST superfamily	gstI	-	2.5.1.18	ko:K00799,ko:K11209	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_N,GST_N_2
k59_859874_1	381666.H16_A1807	0.000345	42.0	COG0119@1|root,COG0119@2|Bacteria,1MVQG@1224|Proteobacteria,2W05X@28216|Betaproteobacteria,1KGY9@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds	-	-	4.1.3.39	ko:K01666	ko00360,ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00360,map00362,map00621,map00622,map01100,map01120,map01220	M00545,M00569	R00750	RC00307,RC00371	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	DmpG_comm,HMGL-like
k59_859874_2	383381.EH30_10300	1.96e-37	134.0	COG4569@1|root,COG4569@2|Bacteria,1MV23@1224|Proteobacteria,2U26H@28211|Alphaproteobacteria,2K23D@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds	-	-	1.2.1.10	ko:K04073	ko00360,ko00362,ko00620,ko00621,ko00622,ko00650,ko01100,ko01120,ko01220,map00360,map00362,map00620,map00621,map00622,map00650,map01100,map01120,map01220	M00545,M00569	R00228,R01172	RC00004,RC00184,RC01195	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	AcetDehyd-dimer,Semialdhyde_dh
k59_1695821_2	319225.Plut_1624	9.29e-22	93.6	COG4974@1|root,COG4974@2|Bacteria,1FD7Q@1090|Chlorobi	1090|Chlorobi	D	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids	xerC	-	-	ko:K03733	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_249230_1	1463861.JNXE01000001_gene5008	1.41e-43	159.0	COG2936@1|root,COG2936@2|Bacteria,2GK8B@201174|Actinobacteria	201174|Actinobacteria	IQ	Peptidase S15	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
k59_1361744_1	1502724.FF80_01736	6.15e-07	52.4	COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,2TQRC@28211|Alphaproteobacteria,3N67N@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
k59_1361744_2	1054213.HMPREF9946_04728	5.47e-29	112.0	COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,2TVFA@28211|Alphaproteobacteria,2JQEE@204441|Rhodospirillales	204441|Rhodospirillales	S	COG1253 Hemolysins and related proteins containing CBS domains	-	-	-	ko:K06189	-	-	-	-	ko00000,ko02000	9.A.40.1.2	-	-	CBS,CorC_HlyC
k59_305639_1	309807.SRU_1060	2.58e-14	74.7	COG0202@1|root,COG0202@2|Bacteria,4NE8W@976|Bacteroidetes,1FJ43@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
k59_305639_2	671143.DAMO_0567	1.95e-41	141.0	COG0203@1|root,COG0203@2|Bacteria,2NPYQ@2323|unclassified Bacteria	2|Bacteria	J	Ribosomal protein L17	rplQ	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02879,ko:K16193	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
k59_973077_2	78346.BRUM_1133	6.69e-13	72.0	COG1968@1|root,COG1968@2|Bacteria,2GJVG@201174|Actinobacteria,4CZ83@85004|Bifidobacteriales	201174|Actinobacteria	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
k59_1749888_1	1121930.AQXG01000008_gene175	3.07e-24	104.0	COG4826@1|root,COG4826@2|Bacteria,4NG1G@976|Bacteroidetes,1IRRU@117747|Sphingobacteriia	976|Bacteroidetes	O	Belongs to the serpin family	-	-	-	ko:K13963	ko05146,map05146	-	-	-	ko00000,ko00001	-	-	-	Serpin
k59_1695841_1	1380394.JADL01000004_gene5722	7.41e-80	244.0	COG0179@1|root,COG0179@2|Bacteria,1MUPF@1224|Proteobacteria,2TQMB@28211|Alphaproteobacteria,2JR7S@204441|Rhodospirillales	204441|Rhodospirillales	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
k59_1473212_1	1380355.JNIJ01000047_gene228	5.3e-82	264.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,3JR8W@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc
k59_582410_1	643562.Daes_2703	2.64e-53	176.0	COG2940@1|root,COG2940@2|Bacteria,1QAQZ@1224|Proteobacteria,43EC9@68525|delta/epsilon subdivisions,2X0BC@28221|Deltaproteobacteria,2MBPB@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain	-	-	-	ko:K07117	-	-	-	-	ko00000	-	-	-	SET
k59_1638306_1	1041147.AUFB01000028_gene2836	1.13e-08	61.6	COG1940@1|root,COG1940@2|Bacteria,1NFM0@1224|Proteobacteria,2U1BM@28211|Alphaproteobacteria,4BD1Y@82115|Rhizobiaceae	28211|Alphaproteobacteria	GK	ROK family	-	-	-	-	-	-	-	-	-	-	-	-	ROK
k59_918548_1	396588.Tgr7_0775	4.85e-127	372.0	COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,1RPZS@1236|Gammaproteobacteria,1WXJ6@135613|Chromatiales	135613|Chromatiales	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
k59_1252079_1	411465.PEPMIC_01628	5.86e-63	196.0	COG0197@1|root,COG0197@2|Bacteria,1V1AY@1239|Firmicutes,24FQX@186801|Clostridia,22H73@1570339|Peptoniphilaceae	186801|Clostridia	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	-	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
k59_1252079_2	370438.PTH_0328	7.17e-07	48.1	COG0255@1|root,COG0255@2|Bacteria,1VEME@1239|Firmicutes,24QV1@186801|Clostridia,262YR@186807|Peptococcaceae	186801|Clostridia	J	Belongs to the universal ribosomal protein uL29 family	rpmC	-	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
k59_527657_1	67373.JOBF01000012_gene3992	1.37e-102	309.0	COG2141@1|root,COG2141@2|Bacteria,2GKP1@201174|Actinobacteria	201174|Actinobacteria	C	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_1749905_2	1379270.AUXF01000005_gene655	1.11e-15	73.6	COG0634@1|root,COG0634@2|Bacteria,1ZTH7@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Phosphoribosyl transferase domain	-	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
k59_305665_1	1415779.JOMH01000001_gene2363	5.56e-10	60.5	COG2020@1|root,COG2020@2|Bacteria,1MWU6@1224|Proteobacteria,1S2PS@1236|Gammaproteobacteria,1X6TI@135614|Xanthomonadales	135614|Xanthomonadales	O	NnrU protein	-	-	-	-	-	-	-	-	-	-	-	-	NnrU
k59_305665_2	101510.RHA1_ro04202	2.33e-18	82.0	COG2197@1|root,COG2197@2|Bacteria,2IFE7@201174|Actinobacteria,4FYGI@85025|Nocardiaceae	201174|Actinobacteria	K	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_805665_1	118163.Ple7327_2337	3.24e-67	210.0	COG1853@1|root,COG1853@2|Bacteria,1G4QZ@1117|Cyanobacteria	1117|Cyanobacteria	S	Flavin reductase like domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
k59_1306437_1	365044.Pnap_2183	7.37e-33	129.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2VHCZ@28216|Betaproteobacteria,4A9J4@80864|Comamonadaceae	28216|Betaproteobacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1083718_1	1177181.T9A_02807	3.78e-83	256.0	COG1804@1|root,COG1804@2|Bacteria,1MW1H@1224|Proteobacteria,1RN9B@1236|Gammaproteobacteria,1XID3@135619|Oceanospirillales	135619|Oceanospirillales	C	carnitine dehydratase	-	-	5.1.99.4	ko:K01796	ko00120,ko01100,ko04146,map00120,map01100,map04146	M00104	R08734,R08739	RC02345	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_transf_3
k59_1083720_1	1123008.KB905697_gene3358	6.03e-11	67.8	COG0577@1|root,COG0577@2|Bacteria,4NFUG@976|Bacteroidetes,2FM5B@200643|Bacteroidia,22X15@171551|Porphyromonadaceae	976|Bacteroidetes	V	ABC transporter, permease protein	macB_3	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_1584010_1	1042375.AFPL01000008_gene3198	1.21e-05	52.8	2DB6N@1|root,2Z7HZ@2|Bacteria,1PQ9P@1224|Proteobacteria,1RRV9@1236|Gammaproteobacteria,465YP@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4392)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4392
k59_1528200_1	69279.BG36_09600	1.06e-86	263.0	COG1173@1|root,COG1173@2|Bacteria,1MVHY@1224|Proteobacteria,2TQVQ@28211|Alphaproteobacteria,43JAB@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	MA20_19550	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
k59_1528200_2	69279.BG36_09605	5.01e-47	159.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TQJC@28211|Alphaproteobacteria,43J58@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_1029506_1	981384.AEYW01000014_gene131	8.3e-80	244.0	COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,4NC5D@97050|Ruegeria	28211|Alphaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve,rve_3
k59_193833_1	369723.Strop_3951	1.21e-78	251.0	COG0028@1|root,COG0028@2|Bacteria,2GKU4@201174|Actinobacteria,4DHQS@85008|Micromonosporales	201174|Actinobacteria	EH	Thiamine pyrophosphate enzyme, central domain	ilvB2	GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.2.1.6,4.1.1.7	ko:K01576,ko:K01652	ko00290,ko00627,ko00650,ko00660,ko00770,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00290,map00627,map00650,map00660,map00770,map01100,map01110,map01120,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R01764,R02672,R03050,R04672,R04673,R08648	RC00027,RC00106,RC00595,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_1361800_1	402626.Rpic_2177	5.37e-71	226.0	COG1960@1|root,COG1960@2|Bacteria,1MU2V@1224|Proteobacteria,2VI1V@28216|Betaproteobacteria,1K1EX@119060|Burkholderiaceae	28216|Betaproteobacteria	C	acyl-CoA dehydrogenase	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_1139906_1	316067.Geob_2011	2.32e-70	222.0	COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,42N2N@68525|delta/epsilon subdivisions,2WK67@28221|Deltaproteobacteria,43VF5@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	probably responsible for the translocation of the substrate across the membrane	pstC	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	iAF987.Gmet_2702	BPD_transp_1
k59_1361804_1	926569.ANT_10060	1.9e-07	50.1	COG0089@1|root,COG0089@2|Bacteria,2G73T@200795|Chloroflexi	200795|Chloroflexi	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	-	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
k59_1361804_2	926569.ANT_10070	3.33e-64	203.0	COG0090@1|root,COG0090@2|Bacteria,2G65E@200795|Chloroflexi	200795|Chloroflexi	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
k59_1252119_1	926569.ANT_09870	4.72e-34	132.0	COG1595@1|root,COG1595@2|Bacteria,2GBP1@200795|Chloroflexi	200795|Chloroflexi	K	N-terminal 7TM region of histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_7TM
k59_193842_1	1123242.JH636436_gene552	1.72e-34	130.0	COG2520@1|root,COG2520@2|Bacteria,2J4W5@203682|Planctomycetes	203682|Planctomycetes	J	Dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	Dimerisation2,Methyltransf_2
k59_1749946_1	1116472.MGMO_24c00010	7.09e-09	59.7	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,1RYUH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Adenylyl cyclase class-3 4 guanylyl cyclase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
k59_1029521_2	479434.Sthe_1472	1.42e-26	106.0	COG1024@1|root,COG1024@2|Bacteria,2G5JW@200795|Chloroflexi,27XIU@189775|Thermomicrobia	189775|Thermomicrobia	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
k59_918605_1	867903.ThesuDRAFT_00508	4.82e-44	154.0	COG0010@1|root,COG0010@2|Bacteria,1TP2A@1239|Firmicutes,2493V@186801|Clostridia,3WDFT@538999|Clostridiales incertae sedis	186801|Clostridia	E	Arginase family	speB	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
k59_1695903_1	316274.Haur_4702	1.69e-20	95.1	COG1396@1|root,COG2909@1|root,COG1396@2|Bacteria,COG2909@2|Bacteria	2|Bacteria	K	trisaccharide binding	msr0960	-	-	ko:K03556	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3,HTH_31
k59_1749947_1	748247.AZKH_4517	1.78e-59	194.0	COG0703@1|root,COG1476@1|root,COG0703@2|Bacteria,COG1476@2|Bacteria,1MX66@1224|Proteobacteria,2VK91@28216|Betaproteobacteria,2KYAV@206389|Rhodocyclales	206389|Rhodocyclales	F	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	boxR	-	-	ko:K15546	-	-	-	-	ko00000,ko03000	-	-	-	HTH_31,SKI
k59_305715_1	1122132.AQYH01000016_gene2887	9.54e-81	254.0	COG0260@1|root,COG0260@2|Bacteria,1MUIN@1224|Proteobacteria,2TSI6@28211|Alphaproteobacteria,4B8TH@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Belongs to the peptidase M17 family	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17
k59_1584041_1	1122135.KB893170_gene2664	5.29e-16	72.8	COG5460@1|root,COG5460@2|Bacteria,1NQ45@1224|Proteobacteria	1224|Proteobacteria	S	Uncharacterized conserved protein (DUF2164)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2164
k59_360437_2	999419.HMPREF1077_03083	7.7e-22	92.4	COG0745@1|root,COG0745@2|Bacteria,4NHXA@976|Bacteroidetes,2G2YZ@200643|Bacteroidia,22XSA@171551|Porphyromonadaceae	976|Bacteroidetes	T	Transcriptional regulatory protein, C terminal	cusR	-	-	ko:K07665	ko02020,map02020	M00452,M00745	-	-	ko00000,ko00001,ko00002,ko01504,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_1306485_1	1101192.KB910516_gene4125	2.01e-09	64.3	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2U4DT@28211|Alphaproteobacteria,1JQUY@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_1640977_1	1366050.N234_05230	3.34e-26	109.0	COG0583@1|root,COG0583@2|Bacteria,1MWY0@1224|Proteobacteria,2VJWP@28216|Betaproteobacteria,1K0AI@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_252014_1	1237149.C900_03836	4.9e-46	162.0	COG0591@1|root,COG0591@2|Bacteria	2|Bacteria	E	symporter activity	putP_2	-	-	ko:K03307,ko:K11928	-	-	-	-	ko00000,ko02000	2.A.21,2.A.21.2	-	-	SSF
k59_1419794_1	189753.AXAS01000011_gene7551	1.08e-38	144.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2URQN@28211|Alphaproteobacteria,3K6JB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC_sub_bind
k59_862684_1	648757.Rvan_3509	5e-38	138.0	COG1262@1|root,COG1262@2|Bacteria,1MUNC@1224|Proteobacteria,2TQXE@28211|Alphaproteobacteria,3N7UE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2,FGE-sulfatase,Methyltransf_33
k59_862684_2	1449049.JONW01000011_gene2385	1.65e-13	71.6	COG1262@1|root,COG4301@1|root,COG1262@2|Bacteria,COG4301@2|Bacteria,1MUNC@1224|Proteobacteria,2TQXE@28211|Alphaproteobacteria,2KFXT@204458|Caulobacterales	204458|Caulobacterales	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2,FGE-sulfatase,Methyltransf_33
k59_1142937_1	313603.FB2170_11616	7.4e-45	166.0	COG0531@1|root,COG0531@2|Bacteria,4NFFX@976|Bacteroidetes,1HZT1@117743|Flavobacteriia	976|Bacteroidetes	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease
k59_325868_1	1317118.ATO8_02065	3.44e-62	204.0	COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,2TQSI@28211|Alphaproteobacteria,4KKEU@93682|Roseivivax	28211|Alphaproteobacteria	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
k59_1272253_1	519442.Huta_0973	2.05e-06	54.7	arCOG02980@1|root,arCOG02980@2157|Archaea,2XTKT@28890|Euryarchaeota,23SJA@183963|Halobacteria	183963|Halobacteria	S	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_493802_2	413816.BBJP01000010_gene634	1.73e-37	130.0	COG3439@1|root,arCOG02761@2157|Archaea,2XZR9@28890|Euryarchaeota,23WSC@183963|Halobacteria	183963|Halobacteria	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
k59_1768617_1	242527.Q6V7M4_9CAUD	5.9e-44	148.0	4QGY0@10239|Viruses,4QWBI@35237|dsDNA viruses  no RNA stage,4QR52@28883|Caudovirales	28883|Caudovirales	S	transferase activity, transferring acyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_493813_1	430998.XP_007678782.1	0.00019	49.7	KOG0301@1|root,KOG0301@2759|Eukaryota,38BSR@33154|Opisthokonta,3NUQN@4751|Fungi,3QJG5@4890|Ascomycota,1ZX7K@147541|Dothideomycetes,3MJ69@451867|Dothideomycetidae	4751|Fungi	I	PFU (PLAA family ubiquitin binding)	lub1	GO:0000726,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006303,GO:0006325,GO:0006464,GO:0006508,GO:0006511,GO:0006725,GO:0006807,GO:0006914,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0010992,GO:0016043,GO:0016236,GO:0016567,GO:0016569,GO:0016570,GO:0016574,GO:0019538,GO:0019725,GO:0019941,GO:0030163,GO:0032182,GO:0032446,GO:0033554,GO:0034517,GO:0034641,GO:0035973,GO:0036211,GO:0042592,GO:0043130,GO:0043161,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051603,GO:0051716,GO:0061912,GO:0061919,GO:0065007,GO:0065008,GO:0070647,GO:0071704,GO:0071840,GO:0072671,GO:0090304,GO:1901360,GO:1901564,GO:1901565,GO:1901575	-	ko:K14018	ko04141,map04141	-	-	-	ko00000,ko00001	-	-	-	PFU,PUL,WD40
k59_768106_1	861299.J421_3848	6.27e-75	243.0	COG0443@1|root,COG0443@2|Bacteria,1ZT75@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
k59_1436207_1	944479.JQLX01000013_gene1447	1.5e-110	334.0	COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,42M14@68525|delta/epsilon subdivisions,2WIN7@28221|Deltaproteobacteria,2M6KR@213113|Desulfurellales	28221|Deltaproteobacteria	I	Biotin carboxylase C-terminal domain	pccA	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
k59_879938_1	388413.ALPR1_05705	1.9e-08	60.8	COG4447@1|root,COG4447@2|Bacteria,4NESU@976|Bacteroidetes,47M5A@768503|Cytophagia	976|Bacteroidetes	S	Sortilin, neurotensin receptor 3,	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
k59_1160139_1	765914.ThisiDRAFT_1928	6.01e-101	323.0	COG0574@1|root,COG1080@1|root,COG1372@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,COG1372@2|Bacteria,1MU0R@1224|Proteobacteria,1RP3T@1236|Gammaproteobacteria,1WXGJ@135613|Chromatiales	135613|Chromatiales	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_1545826_1	68170.KL590510_gene7215	1.4e-83	251.0	COG3647@1|root,COG3647@2|Bacteria,2IATE@201174|Actinobacteria,4E3YF@85010|Pseudonocardiales	201174|Actinobacteria	S	Predicted membrane protein (DUF2238)	-	-	-	ko:K08984	-	-	-	-	ko00000	-	-	-	DUF2238
k59_266989_1	258594.RPA3634	9.79e-31	125.0	COG0166@1|root,COG0176@1|root,COG0166@2|Bacteria,COG0176@2|Bacteria,1MUFP@1224|Proteobacteria,2TQKP@28211|Alphaproteobacteria,3JR2T@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2,5.3.1.9	ko:K01810,ko:K13810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00004,M00007,M00114	R01827,R02739,R02740,R03321	RC00376,RC00439,RC00563,RC00604	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI,TAL_FSA
k59_768154_1	1385511.N783_16725	9.84e-23	101.0	COG3181@1|root,COG3181@2|Bacteria,1V0HH@1239|Firmicutes,4HF4M@91061|Bacilli	91061|Bacilli	S	Tripartite tricarboxylate transporter family receptor	-	-	-	ko:K07795	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctC
k59_1493094_1	661478.OP10G_2200	5.49e-42	152.0	2DQGC@1|root,336PP@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4872)	-	-	-	-	-	-	-	-	-	-	-	-	BtrH_N,DUF4872
k59_715671_1	118166.JH976537_gene2683	1.06e-12	73.2	COG0747@1|root,COG0747@2|Bacteria,1GBHH@1117|Cyanobacteria,1HEP5@1150|Oscillatoriales	1117|Cyanobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_5
k59_1545854_1	1379698.RBG1_1C00001G0022	2.26e-24	98.2	COG0377@1|root,COG0377@2|Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
k59_1545854_2	742725.HMPREF9450_00510	9.05e-21	85.9	COG0838@1|root,COG0838@2|Bacteria,4NQET@976|Bacteroidetes,2FTGA@200643|Bacteroidia	976|Bacteroidetes	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoA	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0055114,GO:0098796,GO:1902494	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
k59_380145_1	1521187.JPIM01000102_gene3716	8.23e-104	312.0	COG2876@1|root,COG2876@2|Bacteria,2G643@200795|Chloroflexi,37722@32061|Chloroflexia	32061|Chloroflexia	E	PFAM DAHP synthetase I KDSA	-	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
k59_1049027_1	1218103.CIN01S_04_04900	3.1e-55	189.0	COG0265@1|root,COG0265@2|Bacteria,4NFCS@976|Bacteroidetes,1HXT7@117743|Flavobacteriia,3ZPMF@59732|Chryseobacterium	976|Bacteroidetes	O	Trypsin	htrA	-	-	-	-	-	-	-	-	-	-	-	PDZ_1,PDZ_2,Trypsin_2
k59_1213751_1	649747.HMPREF0083_02683	7.6e-91	280.0	COG0332@1|root,COG0332@2|Bacteria,1TP0K@1239|Firmicutes,4HATK@91061|Bacilli,26QJP@186822|Paenibacillaceae	91061|Bacilli	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
k59_1213753_1	326427.Cagg_3490	1.78e-25	108.0	COG0471@1|root,COG0490@1|root,COG0471@2|Bacteria,COG0490@2|Bacteria,2G7T5@200795|Chloroflexi,376QR@32061|Chloroflexia	32061|Chloroflexia	P	Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,TrkA_C
k59_157363_2	1005048.CFU_3247	1.4e-36	129.0	COG0662@1|root,COG0662@2|Bacteria,1RHWU@1224|Proteobacteria,2VT6E@28216|Betaproteobacteria,4779M@75682|Oxalobacteraceae	28216|Betaproteobacteria	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_493923_1	300852.55772630	2.34e-79	255.0	COG0365@1|root,COG0365@2|Bacteria,1WI8W@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_1715775_1	91464.S7335_2844	2.62e-42	156.0	COG0653@1|root,COG0653@2|Bacteria,1G1B4@1117|Cyanobacteria,1GYJY@1129|Synechococcus	1117|Cyanobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SecA_DEAD,SecA_PP_bind,SecA_SW
k59_1272393_1	709986.Deima_1326	1.54e-12	67.0	COG3383@1|root,COG3383@2|Bacteria,1WJDD@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	TIGRFAM formate dehydrogenase, alpha subunit, archaeal-type	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_1272393_2	926569.ANT_29920	2.97e-47	169.0	COG3383@1|root,COG3383@2|Bacteria,2GBH3@200795|Chloroflexi	200795|Chloroflexi	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_45421_1	1500257.JQNM01000014_gene2919	2.74e-76	241.0	COG4638@1|root,COG4638@2|Bacteria,1MX47@1224|Proteobacteria,2TV03@28211|Alphaproteobacteria,4B9MF@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Rieske [2Fe-2S] domain	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
k59_102139_1	926550.CLDAP_32780	8.12e-115	338.0	COG1173@1|root,COG1173@2|Bacteria,2G6HB@200795|Chloroflexi	200795|Chloroflexi	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
k59_102139_2	1265505.ATUG01000002_gene1456	9.11e-28	110.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,42P18@68525|delta/epsilon subdivisions,2WKTS@28221|Deltaproteobacteria,2MJEJ@213118|Desulfobacterales	28221|Deltaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_1436312_1	631454.N177_3094	7.06e-31	122.0	COG2267@1|root,COG3629@1|root,COG3899@1|root,COG2267@2|Bacteria,COG3629@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Abhydrolase_1,Guanylate_cyc,TPR_4
k59_1436312_2	670292.JH26_02675	3.18e-09	55.8	COG3339@1|root,COG3339@2|Bacteria,1MZR5@1224|Proteobacteria,2UCIB@28211|Alphaproteobacteria,1JYVG@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1232)	MA20_25305	-	-	-	-	-	-	-	-	-	-	-	DUF1232
k59_326007_1	1038860.AXAP01000061_gene2387	6.95e-99	299.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2TSA7@28211|Alphaproteobacteria,3JTRC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_1049055_2	1108045.GORHZ_193_00110	2.99e-07	56.6	COG0583@1|root,COG0583@2|Bacteria,2HGRW@201174|Actinobacteria,4GAF0@85026|Gordoniaceae	201174|Actinobacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_1436315_1	861299.J421_4115	4.55e-18	89.7	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_1381690_1	926569.ANT_27540	1.13e-85	263.0	COG0460@1|root,COG0460@2|Bacteria,2G6PU@200795|Chloroflexi	200795|Chloroflexi	E	homoserine dehydrogenase	metM	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,Homoserine_dh,NAD_binding_3
k59_1545903_2	1379270.AUXF01000006_gene92	9.24e-11	59.3	COG1722@1|root,COG1722@2|Bacteria,1ZU7T@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
k59_1545903_3	1380358.JADJ01000007_gene3058	3.13e-08	56.2	COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,1RNAZ@1236|Gammaproteobacteria,1XIJ4@135619|Oceanospirillales	135619|Oceanospirillales	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
k59_1272418_1	555778.Hneap_0662	6.61e-85	266.0	COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,1RM92@1236|Gammaproteobacteria,1WWJ8@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
k59_1545906_2	717606.PaecuDRAFT_4034	6.83e-09	57.8	COG1595@1|root,COG1595@2|Bacteria,1V7S9@1239|Firmicutes,4HJ5E@91061|Bacilli,26UZY@186822|Paenibacillaceae	91061|Bacilli	K	Belongs to the sigma-70 factor family. ECF subfamily	sigW9	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_1768766_1	994479.GL877878_gene114	2.27e-07	55.5	COG0477@1|root,COG0477@2|Bacteria,2GIYR@201174|Actinobacteria,4E03T@85010|Pseudonocardiales	201174|Actinobacteria	EGP	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
k59_546672_1	270374.MELB17_12686	4.62e-91	283.0	COG0538@1|root,COG0538@2|Bacteria,1MUIB@1224|Proteobacteria,1RNT7@1236|Gammaproteobacteria,469IH@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	Isocitrate/isopropylmalate dehydrogenase	-	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
k59_1715817_1	666686.B1NLA3E_11700	2.51e-22	99.0	COG0679@1|root,COG0679@2|Bacteria,1UEYG@1239|Firmicutes,4HD45@91061|Bacilli,1ZD15@1386|Bacillus	91061|Bacilli	S	Membrane transport protein	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
k59_210939_1	383372.Rcas_1762	6.78e-16	82.0	COG0589@1|root,COG0589@2|Bacteria,2G8FB@200795|Chloroflexi,377FW@32061|Chloroflexia	32061|Chloroflexia	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_1381727_2	5057.CADACLAP00006742	1.24e-12	69.3	COG0388@1|root,KOG0805@2759|Eukaryota,39SCM@33154|Opisthokonta,3NU8M@4751|Fungi,3QRRN@4890|Ascomycota,20FAK@147545|Eurotiomycetes	4751|Fungi	E	nitrilase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
k59_102198_1	1336233.JAEH01000018_gene3078	2e-11	70.9	COG0642@1|root,COG2205@2|Bacteria,1N9SU@1224|Proteobacteria,1RMF5@1236|Gammaproteobacteria,2Q9I2@267890|Shewanellaceae	1236|Gammaproteobacteria	T	PFAM ATP-binding region, ATPase domain protein	-	-	2.7.13.3	ko:K02484	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
k59_1049094_1	335543.Sfum_2777	6.99e-71	236.0	COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,42MDI@68525|delta/epsilon subdivisions,2WIVY@28221|Deltaproteobacteria,2MQ89@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Malic enzyme, NAD binding domain	maeB	-	1.1.1.38,1.1.1.40	ko:K00027,ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,ko02020,map00620,map00710,map01100,map01120,map01200,map02020	M00169,M00172	R00214,R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1637	Malic_M,PTA_PTB,malic
k59_435401_1	1267533.KB906733_gene3362	1.22e-61	211.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,3Y7E7@57723|Acidobacteria,2JKGS@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
k59_380239_1	1200792.AKYF01000009_gene2948	5.2e-09	61.2	COG0438@1|root,COG0438@2|Bacteria,1UASH@1239|Firmicutes,4HKSK@91061|Bacilli,26QSQ@186822|Paenibacillaceae	91061|Bacilli	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
k59_1436378_1	710687.KI912270_gene3313	7.8e-77	242.0	COG2072@1|root,COG2072@2|Bacteria,2GM3S@201174|Actinobacteria,235PB@1762|Mycobacteriaceae	201174|Actinobacteria	P	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	ko:K07222	-	-	-	-	ko00000	-	-	-	Pyr_redox_3
k59_882892_1	1282356.H045_02350	6.84e-07	53.9	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1YR7E@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	T	Double sensory domain of two-component sensor kinase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,HAMP,dCache_3
k59_1770936_1	533240.CRC_01319	2.98e-13	75.1	COG1087@1|root,COG1087@2|Bacteria,1G08G@1117|Cyanobacteria,1HJUV@1161|Nostocales	1117|Cyanobacteria	M	Belongs to the NAD(P)-dependent epimerase dehydratase family	galE	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
k59_1770936_2	926569.ANT_06280	1.05e-09	58.5	COG1846@1|root,COG1846@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	DUF4388,HTH_24,MarR_2
k59_1384344_1	426355.Mrad2831_5093	1.38e-15	81.3	COG1053@1|root,COG1053@2|Bacteria,1MX5A@1224|Proteobacteria,2TV7T@28211|Alphaproteobacteria,1JRP2@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	PFAM fumarate reductase succinate dehydrogenase flavoprotein domain protein	-	-	-	ko:K13796	-	-	-	-	ko00000	-	-	-	FAD_binding_2
k59_1605454_1	1125863.JAFN01000001_gene2657	7.36e-30	116.0	COG0811@1|root,COG0811@2|Bacteria,1QNJ1@1224|Proteobacteria,43BH1@68525|delta/epsilon subdivisions,2X6VI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	MotA/TolQ/ExbB proton channel family	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
k59_382843_1	1120971.AUCA01000044_gene1192	2.7e-84	264.0	COG0082@1|root,COG0082@2|Bacteria,1TQ40@1239|Firmicutes,4HA0H@91061|Bacilli,2784T@186823|Alicyclobacillaceae	91061|Bacilli	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
k59_1605458_1	1121445.ATUZ01000016_gene2590	6.53e-39	143.0	COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,42MBH@68525|delta/epsilon subdivisions,2WJQV@28221|Deltaproteobacteria,2M94P@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	PFAM aminotransferase class V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
k59_1050827_1	1234664.AMRO01000035_gene2676	3.3e-20	89.0	COG0183@1|root,COG0183@2|Bacteria,1TP07@1239|Firmicutes,4H9RJ@91061|Bacilli,1WEA8@129337|Geobacillus	91061|Bacilli	I	Belongs to the thiolase family	pcaF	-	2.3.1.174,2.3.1.223	ko:K02615	ko00360,ko01120,map00360,map01120	-	R00829,R09839	RC00004,RC00326,RC03003	ko00000,ko00001,ko01000	-	-	-	Thiolase_C,Thiolase_N
k59_1050827_2	931627.MycrhDRAFT_2705	2.97e-26	106.0	COG1024@1|root,COG1024@2|Bacteria,2GJDK@201174|Actinobacteria,23DCP@1762|Mycobacteriaceae	201174|Actinobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
k59_1329868_1	566466.NOR53_3332	1.96e-33	124.0	COG0357@1|root,COG0357@2|Bacteria,1MY0K@1224|Proteobacteria,1RMRZ@1236|Gammaproteobacteria,1J67N@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Specifically methylates the N7 position of guanine in position 527 of 16S rRNA	rsmG	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
k59_718150_1	1187851.A33M_4026	5.55e-62	205.0	COG0642@1|root,COG2205@2|Bacteria,1MUAK@1224|Proteobacteria,2TQRE@28211|Alphaproteobacteria,3FCWS@34008|Rhodovulum	28211|Alphaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	2.7.13.3	ko:K07638	ko02020,ko02026,map02020,map02026	M00445,M00742,M00743	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
k59_602858_2	742767.HMPREF9456_03412	3.33e-28	106.0	2EMSQ@1|root,33FF4@2|Bacteria,4P5SB@976|Bacteroidetes,2FV07@200643|Bacteroidia	976|Bacteroidetes	S	Protein of unknown function (DUF1064)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1064
k59_1438593_1	484019.THA_1118	5e-20	94.7	COG1757@1|root,COG1757@2|Bacteria,2GC30@200918|Thermotogae	200918|Thermotogae	C	PFAM Na H antiporter	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_antiporter
k59_1605510_1	504472.Slin_6455	4.64e-23	96.3	COG0500@1|root,COG2226@2|Bacteria,4NEDR@976|Bacteroidetes,47JXK@768503|Cytophagia	976|Bacteroidetes	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
k59_1329911_1	682795.AciX8_4155	2.71e-53	188.0	COG3533@1|root,COG3533@2|Bacteria,3Y3WA@57723|Acidobacteria,2JKD6@204432|Acidobacteriia	204432|Acidobacteriia	S	Beta-L-arabinofuranosidase, GH127	-	-	-	ko:K09955	-	-	-	-	ko00000	-	-	-	Glyco_hydro_127
k59_1329931_1	760117.JN27_07125	3.45e-56	197.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,2VHVB@28216|Betaproteobacteria,4761P@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Insulinase (Peptidase family M16)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_941096_2	570967.JMLV01000004_gene651	1.14e-12	67.8	COG0687@1|root,COG0687@2|Bacteria,1MUYW@1224|Proteobacteria,2TSUZ@28211|Alphaproteobacteria,2JPA2@204441|Rhodospirillales	204441|Rhodospirillales	E	Required for the activity of the bacterial periplasmic transport system of putrescine	potF	-	-	ko:K11069,ko:K11073	ko02010,map02010	M00299,M00300	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1,3.A.1.11.2	-	-	SBP_bac_6,SBP_bac_8
k59_1726051_1	517418.Ctha_1169	8.32e-35	140.0	COG0457@1|root,COG3903@1|root,COG0457@2|Bacteria,COG3903@2|Bacteria	2|Bacteria	K	ADP binding	-	-	-	-	-	-	-	-	-	-	-	-	DUF320,HTH_31,NB-ARC,TIR_2,TPR_12
k59_1336961_2	1116369.KB890025_gene5163	1.04e-17	85.5	COG1960@1|root,COG1960@2|Bacteria,1MVQH@1224|Proteobacteria,2TTX8@28211|Alphaproteobacteria,43J1N@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	I	acyl-CoA dehydrogenase	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_781002_1	1306947.ARQD01000002_gene553	3.25e-16	76.6	COG0694@1|root,COG0694@2|Bacteria,2NQ7X@2323|unclassified Bacteria	2|Bacteria	O	NifU-like domain	nifU	-	-	-	-	-	-	-	-	-	-	-	Nfu_N,NifU
k59_1614822_1	368408.Tpen_0138	5.13e-10	65.1	COG1801@1|root,arCOG04291@2157|Archaea	2157|Archaea	L	DUF72 domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
k59_1170154_2	392499.Swit_4527	4.62e-05	50.1	COG2244@1|root,COG2244@2|Bacteria,1R9I0@1224|Proteobacteria,2TV6V@28211|Alphaproteobacteria,2KD90@204457|Sphingomonadales	204457|Sphingomonadales	S	Membrane protein involved in the export of O-antigen and teichoic acid	-	-	-	ko:K03328	-	-	-	-	ko00000	2.A.66.2	-	-	Polysacc_synt_3
k59_1226003_1	1313172.YM304_38340	7.8e-106	317.0	COG0174@1|root,COG0174@2|Bacteria,2GJ2I@201174|Actinobacteria,4CMV7@84992|Acidimicrobiia	84992|Acidimicrobiia	E	glutamine synthetase	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
k59_503076_1	670292.JH26_02945	6.51e-17	80.1	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2TVFX@28211|Alphaproteobacteria,1JZ5D@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	PALP
k59_1614841_1	1048339.KB913029_gene1872	1.07e-79	250.0	COG0372@1|root,COG0372@2|Bacteria,2GJ7E@201174|Actinobacteria,4ESB0@85013|Frankiales	201174|Actinobacteria	C	Belongs to the citrate synthase family	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
k59_1503666_1	1121335.Clst_1616	2.62e-11	69.3	COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,248JC@186801|Clostridia,3WH5Q@541000|Ruminococcaceae	186801|Clostridia	IQ	AMP-binding enzyme	lcfB	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
k59_1058944_1	663610.JQKO01000008_gene199	1.09e-47	173.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR56@28211|Alphaproteobacteria,3N9V6@45404|Beijerinckiaceae	28211|Alphaproteobacteria	P	haloacid dehalogenase-like hydrolase	cadA	-	-	-	-	-	-	-	-	-	-	-	E1-E2_ATPase,Hemerythrin,Hydrolase
k59_947849_1	118173.KB235914_gene1772	5.76e-14	76.6	COG1020@1|root,COG1020@2|Bacteria,1G2QF@1117|Cyanobacteria,1HD5R@1150|Oscillatoriales	1117|Cyanobacteria	Q	Condensation domain	-	-	-	-	-	-	-	-	-	-	-	-	Condensation
k59_503096_1	1121918.ARWE01000001_gene698	5.37e-48	169.0	COG0534@1|root,COG0534@2|Bacteria,1R3WH@1224|Proteobacteria,42Q54@68525|delta/epsilon subdivisions,2WM10@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	Mate efflux family protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1003476_1	29581.BW37_02383	4.28e-45	160.0	COG3395@1|root,COG3395@2|Bacteria,1MW4G@1224|Proteobacteria,2VI5S@28216|Betaproteobacteria,4764D@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Putative nucleotide-binding of sugar-metabolising enzyme	hop	-	2.7.1.217	ko:K21948	-	-	R11706,R11707	-	ko00000,ko01000	-	-	-	DUF1357_C,DUF1537
k59_391912_1	644966.Tmar_0252	1.48e-72	231.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,1TPE2@1239|Firmicutes,25CRT@186801|Clostridia	186801|Clostridia	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,Rhodanese
k59_1614863_1	580332.Slit_2777	9.54e-55	186.0	COG1030@1|root,COG1030@2|Bacteria,1MUJN@1224|Proteobacteria,2VMUK@28216|Betaproteobacteria	28216|Betaproteobacteria	O	serine protease	nfeD	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	NfeD
k59_1503684_2	1122180.Lokhon_02895	1.78e-53	176.0	COG1595@1|root,COG1595@2|Bacteria,1N00E@1224|Proteobacteria,2U6J3@28211|Alphaproteobacteria,2P97Y@245186|Loktanella	28211|Alphaproteobacteria	K	Sigma-70, region 4	MA20_09680	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
k59_725594_2	244581.IM40_00020	3.34e-110	341.0	COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,2TRBK@28211|Alphaproteobacteria,47EU2@766|Rickettsiales	766|Rickettsiales	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_225083_2	1247963.JPHU01000010_gene2268	2.02e-38	134.0	COG0740@1|root,COG0740@2|Bacteria,1MV46@1224|Proteobacteria,2TR5M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	OU	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
k59_892349_1	314270.RB2083_1588	5.43e-26	104.0	COG2801@1|root,COG2801@2|Bacteria,1RG0C@1224|Proteobacteria,2U7S5@28211|Alphaproteobacteria,3ZHKU@58840|unclassified Rhodobacteraceae	28211|Alphaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_28,HTH_29,HTH_32,rve,rve_3
k59_892349_2	1123360.thalar_02827	1.6e-76	236.0	COG2801@1|root,COG2801@2|Bacteria,1RG0C@1224|Proteobacteria,2U7S5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_28,HTH_29,HTH_32,rve,rve_3
k59_1503691_1	467661.RKLH11_1870	2.5e-43	146.0	COG0315@1|root,COG0315@2|Bacteria,1RCYZ@1224|Proteobacteria,2U747@28211|Alphaproteobacteria,3ZH5R@58840|unclassified Rhodobacteraceae	28211|Alphaproteobacteria	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
k59_225098_2	861299.J421_0601	1.17e-07	55.1	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_280735_1	448385.sce0363	9.24e-72	233.0	COG0515@1|root,COG0515@2|Bacteria,1P913@1224|Proteobacteria,4377Q@68525|delta/epsilon subdivisions,2X28Z@28221|Deltaproteobacteria,2YUDY@29|Myxococcales	28221|Deltaproteobacteria	KLT	Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
k59_836594_1	1379270.AUXF01000002_gene1826	5.26e-156	456.0	COG0843@1|root,COG0843@2|Bacteria,1ZSMG@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_669951_1	357808.RoseRS_0444	6.93e-40	146.0	COG3385@1|root,COG3385@2|Bacteria,2G9A6@200795|Chloroflexi	200795|Chloroflexi	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_947905_1	240015.ACP_1725	4.3e-20	91.7	COG1215@1|root,COG1215@2|Bacteria,3Y31I@57723|Acidobacteria,2JIKW@204432|Acidobacteriia	204432|Acidobacteriia	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
k59_947905_2	671143.DAMO_0611	1.22e-22	97.4	COG1216@1|root,COG1216@2|Bacteria,2NRAF@2323|unclassified Bacteria	2|Bacteria	S	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	GT87
k59_1226090_1	243233.MCA1226	1.18e-71	224.0	COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,1RMD4@1236|Gammaproteobacteria,1XDWZ@135618|Methylococcales	135618|Methylococcales	U	PFAM MotA TolQ ExbB proton channel	tolQ	-	-	ko:K03562	ko01120,map01120	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	MotA_ExbB
k59_1226090_2	1123256.KB907932_gene2934	3.62e-35	125.0	COG0824@1|root,COG0824@2|Bacteria,1MZH6@1224|Proteobacteria,1S93F@1236|Gammaproteobacteria,1X6W5@135614|Xanthomonadales	135614|Xanthomonadales	S	Acyl-CoA thioesterase	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT
k59_1614921_1	1286632.P278_24730	7.22e-67	220.0	COG2303@1|root,COG2303@2|Bacteria,4NEHP@976|Bacteroidetes,1HXAS@117743|Flavobacteriia	976|Bacteroidetes	E	COG2303 Choline dehydrogenase and related	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2,GMC_oxred_C,GMC_oxred_N
k59_1059012_1	404589.Anae109_2021	5.82e-93	297.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,42MKU@68525|delta/epsilon subdivisions,2WJR3@28221|Deltaproteobacteria,2YWBK@29|Myxococcales	28221|Deltaproteobacteria	L	UvrD-like helicase C-terminal domain	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_892392_2	1123229.AUBC01000005_gene539	2.76e-60	207.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2TQK9@28211|Alphaproteobacteria,3JTF6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_836623_1	373903.Hore_03950	1.29e-47	164.0	COG0667@1|root,COG0667@2|Bacteria,1UKPC@1239|Firmicutes,24F85@186801|Clostridia,3WAGJ@53433|Halanaerobiales	186801|Clostridia	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_1337064_1	1121920.AUAU01000015_gene1161	2.61e-116	351.0	COG0365@1|root,COG0365@2|Bacteria	2|Bacteria	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	prpE	GO:0003674,GO:0003824,GO:0003987,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006091,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0017144,GO:0031974,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046950,GO:0046951,GO:0050218,GO:0070013,GO:0071704,GO:1901568,GO:1901570,GO:1901576,GO:1902224	6.2.1.1,6.2.1.17	ko:K01895,ko:K01908	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iJN746.PP_2351	ACAS_N,AMP-binding,AMP-binding_C
k59_503177_1	1499968.TCA2_4373	1.56e-05	53.9	COG1653@1|root,COG1653@2|Bacteria,1UQZ3@1239|Firmicutes,4HAVZ@91061|Bacilli,26XY0@186822|Paenibacillaceae	91061|Bacilli	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K17315	ko02010,map02010	M00605	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.24,3.A.1.1.30	-	-	SBP_bac_1
k59_836627_2	662755.CRES_2027	4.16e-46	158.0	COG0177@1|root,COG0177@2|Bacteria,2GJ01@201174|Actinobacteria,22KIT@1653|Corynebacteriaceae	201174|Actinobacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0030312,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
k59_1392496_1	219305.MCAG_04813	2.28e-41	146.0	COG0667@1|root,COG0667@2|Bacteria,2GKEP@201174|Actinobacteria,4D972@85008|Micromonosporales	201174|Actinobacteria	C	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_1392496_2	1279038.KB907343_gene2408	1.38e-05	48.9	COG1472@1|root,COG1472@2|Bacteria,1MVIV@1224|Proteobacteria,2TS28@28211|Alphaproteobacteria,2JR2T@204441|Rhodospirillales	204441|Rhodospirillales	G	Fibronectin type III-like domain	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
k59_558609_1	379066.GAU_2776	7.64e-17	85.9	COG0515@1|root,COG0515@2|Bacteria,1ZTFJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Serine/Threonine protein kinases, catalytic domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
k59_113962_1	1380391.JIAS01000013_gene3518	1.27e-88	271.0	COG1177@1|root,COG1177@2|Bacteria,1MVC5@1224|Proteobacteria,2TRRJ@28211|Alphaproteobacteria,2JQ7X@204441|Rhodospirillales	204441|Rhodospirillales	E	COG1177 ABC-type spermidine putrescine transport system, permease component II	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
k59_1114843_1	909663.KI867150_gene1130	1.31e-56	186.0	COG1924@1|root,COG1924@2|Bacteria,1R6HU@1224|Proteobacteria,42R04@68525|delta/epsilon subdivisions,2WMZ2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	PFAM ATPase, BadF BadG BcrA BcrD type	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
k59_60578_1	349124.Hhal_0857	4.33e-22	93.6	COG0088@1|root,COG0088@2|Bacteria,1MXPF@1224|Proteobacteria,1RNNK@1236|Gammaproteobacteria,1WW16@135613|Chromatiales	135613|Chromatiales	J	Forms part of the polypeptide exit tunnel	rplD	-	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
k59_1228531_1	373994.Riv7116_2666	9.59e-53	179.0	COG0216@1|root,COG0216@2|Bacteria,1FZY4@1117|Cyanobacteria,1HJN8@1161|Nostocales	1117|Cyanobacteria	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
k59_1450619_1	262724.TT_P0070	2.93e-39	140.0	COG1030@1|root,COG1030@2|Bacteria,1WKAY@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1061167_1	926569.ANT_01340	3.06e-100	307.0	COG2812@1|root,COG2812@2|Bacteria,2G5PK@200795|Chloroflexi	200795|Chloroflexi	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
k59_1617053_1	344747.PM8797T_17999	2.7e-16	85.1	COG1716@1|root,COG2203@1|root,COG2208@1|root,COG1716@2|Bacteria,COG2203@2|Bacteria,COG2208@2|Bacteria,2IWVF@203682|Planctomycetes	203682|Planctomycetes	T	FHA domain	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	FHA,GAF_2,SpoIIE
k59_1283653_1	68170.KL590477_gene2086	0.000177	47.0	COG0413@1|root,COG0413@2|Bacteria,2GJP6@201174|Actinobacteria,4DZTC@85010|Pseudonocardiales	201174|Actinobacteria	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	GO:0000287,GO:0003674,GO:0003824,GO:0003864,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0016742,GO:0019752,GO:0032787,GO:0034641,GO:0040007,GO:0042364,GO:0042398,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0072330,GO:1901564,GO:1901566,GO:1901576	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
k59_1283653_2	572544.Ilyop_1091	1.39e-08	56.2	COG1529@1|root,COG1529@2|Bacteria,379CG@32066|Fusobacteria	32066|Fusobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding	-	-	1.17.1.4	ko:K00087	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_1172402_1	1459636.NTE_03311	9.74e-43	139.0	arCOG08782@1|root,arCOG08782@2157|Archaea,41SVH@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1172402_2	1459636.NTE_03310	4.34e-34	117.0	COG1145@1|root,arCOG00291@2157|Archaea,41SNB@651137|Thaumarchaeota	651137|Thaumarchaeota	C	NADH ubiquinone oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
k59_449889_1	471852.Tcur_2290	2.02e-39	143.0	COG2047@1|root,COG2047@2|Bacteria,2I2H9@201174|Actinobacteria,4EGJA@85012|Streptosporangiales	201174|Actinobacteria	S	PAC2 family	-	-	-	-	-	-	-	-	-	-	-	-	PAC2
k59_1228553_1	398578.Daci_5724	2.86e-30	120.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2VH8J@28216|Betaproteobacteria,4ABRB@80864|Comamonadaceae	28216|Betaproteobacteria	P	heavy metal translocating P-type ATPase	-	GO:0000041,GO:0000139,GO:0000166,GO:0003674,GO:0003824,GO:0004008,GO:0005215,GO:0005375,GO:0005488,GO:0005507,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005768,GO:0005770,GO:0005794,GO:0005802,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006825,GO:0006873,GO:0006874,GO:0006875,GO:0006878,GO:0008144,GO:0008150,GO:0008324,GO:0009987,GO:0010035,GO:0010038,GO:0012505,GO:0015075,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015677,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019725,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030003,GO:0030554,GO:0031090,GO:0031224,GO:0031226,GO:0031410,GO:0031982,GO:0031984,GO:0032553,GO:0032555,GO:0032559,GO:0032588,GO:0034220,GO:0035434,GO:0035639,GO:0036094,GO:0042221,GO:0042592,GO:0042623,GO:0042625,GO:0042626,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0043682,GO:0044422,GO:0044424,GO:0044425,GO:0044431,GO:0044444,GO:0044446,GO:0044459,GO:0044464,GO:0046688,GO:0046872,GO:0046873,GO:0046914,GO:0046915,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051179,GO:0051208,GO:0051234,GO:0051235,GO:0055065,GO:0055070,GO:0055074,GO:0055076,GO:0055080,GO:0055082,GO:0055085,GO:0060003,GO:0065007,GO:0065008,GO:0071944,GO:0072503,GO:0072507,GO:0090662,GO:0097159,GO:0097367,GO:0097708,GO:0098588,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:0098791,GO:0099131,GO:0099132,GO:1901265,GO:1901363	3.6.3.54	ko:K17686,ko:K19597	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5,3.A.3.5.20	-	-	E1-E2_ATPase,HMA,Hydrolase
k59_1450639_1	1262914.BN533_01772	5.39e-12	66.6	COG1121@1|root,COG1121@2|Bacteria,1TQ68@1239|Firmicutes,4H4H4@909932|Negativicutes	909932|Negativicutes	P	ABC transporter	-	-	-	ko:K09817	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC_tran
k59_1450639_2	383372.Rcas_1591	2.27e-14	73.6	COG0803@1|root,COG0803@2|Bacteria,2G8F6@200795|Chloroflexi,37738@32061|Chloroflexia	32061|Chloroflexia	P	Belongs to the bacterial solute-binding protein 9 family	-	-	-	ko:K02077,ko:K09818	-	M00243,M00244	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ZnuA
k59_1061181_1	1121403.AUCV01000004_gene2011	3.19e-23	102.0	COG0477@1|root,COG2814@2|Bacteria,1QWMM@1224|Proteobacteria,42PZZ@68525|delta/epsilon subdivisions,2WJ1J@28221|Deltaproteobacteria,2MIYY@213118|Desulfobacterales	28221|Deltaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	ko:K08223	-	-	-	-	ko00000,ko02000	2.A.1.35	-	-	MFS_1
k59_505433_1	1267535.KB906767_gene1620	6.16e-31	124.0	COG0577@1|root,COG0577@2|Bacteria,3Y41Z@57723|Acidobacteria,2JI5N@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_283100_1	639030.JHVA01000001_gene366	4.37e-25	103.0	COG0586@1|root,COG0607@1|root,COG0586@2|Bacteria,COG0607@2|Bacteria,3Y3N9@57723|Acidobacteria,2JHWT@204432|Acidobacteriia	204432|Acidobacteriia	P	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese,SNARE_assoc
k59_283100_2	1179778.PMM47T1_12618	1.4e-10	61.6	COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,1RNVM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
k59_338344_1	1117958.PE143B_0129225	5.12e-24	100.0	COG3566@1|root,COG3566@2|Bacteria,1RDHK@1224|Proteobacteria,1S79H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2213)	-	-	-	ko:K09960	-	-	-	-	ko00000	-	-	-	DUF2213
k59_338344_2	1304883.KI912532_gene1203	8.57e-12	67.4	COG2369@1|root,COG2369@2|Bacteria,1RFUM@1224|Proteobacteria,2VTZM@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Phage head morphogenesis protein, SPP1 gp7 family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_Mu_F
k59_838758_1	706587.Desti_0841	1.57e-38	146.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,42PDA@68525|delta/epsilon subdivisions,2WK05@28221|Deltaproteobacteria,2MREH@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	1.3.1.34	ko:K00219	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_FMN,Pyr_redox_2
k59_5185_1	1382356.JQMP01000001_gene1178	1.88e-49	162.0	COG2080@1|root,COG2080@2|Bacteria,2G8E9@200795|Chloroflexi,27Z6U@189775|Thermomicrobia	189775|Thermomicrobia	C	[2Fe-2S] binding domain	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
k59_5185_2	977880.RALTA_A2830	9.37e-21	94.4	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2VJBN@28216|Betaproteobacteria,1KGP4@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.17.1.4	ko:K00087	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_1394748_1	379066.GAU_1936	1.29e-105	321.0	COG2987@1|root,COG2987@2|Bacteria,1ZSQX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
k59_1320699_1	1504981.KO116_1633	8.97e-30	109.0	COG0838@1|root,COG0838@2|Bacteria,1N03S@1224|Proteobacteria,1SATQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	-	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
k59_1597781_1	1095769.CAHF01000022_gene254	3.36e-24	104.0	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2WI6E@28216|Betaproteobacteria,473WW@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS_3,dCache_1
k59_1762134_1	1430440.MGMSRv2_0049	1.19e-47	154.0	COG0198@1|root,COG0198@2|Bacteria,1MZQD@1224|Proteobacteria,2UC6Y@28211|Alphaproteobacteria,2JT9D@204441|Rhodospirillales	204441|Rhodospirillales	J	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit	rplX	-	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
k59_1762134_2	314271.RB2654_11103	1.58e-42	141.0	COG0093@1|root,COG0093@2|Bacteria,1RCWZ@1224|Proteobacteria,2U743@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
k59_1540550_1	420324.KI912080_gene8208	4.29e-108	321.0	COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,2TS6X@28211|Alphaproteobacteria,1JX9I@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Putative transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
k59_762841_1	910314.HMPREF9220_0698	4.45e-05	52.0	COG1450@1|root,COG1450@2|Bacteria,1UKP4@1239|Firmicutes,4H9BE@909932|Negativicutes	909932|Negativicutes	NU	Type II and III secretion system protein	-	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Secretin,Secretin_N
k59_1486744_1	1068980.ARVW01000001_gene5682	1.85e-42	156.0	COG0028@1|root,COG0028@2|Bacteria,2GM6Y@201174|Actinobacteria,4DXB8@85010|Pseudonocardiales	201174|Actinobacteria	EH	Belongs to the TPP enzyme family	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_818764_1	1278073.MYSTI_02176	5.29e-27	114.0	COG0577@1|root,COG0577@2|Bacteria,1NREW@1224|Proteobacteria	1224|Proteobacteria	V	COG0577 ABC-type antimicrobial peptide transport system permease component	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_932979_1	570967.JMLV01000012_gene3184	7.78e-35	124.0	COG0440@1|root,COG0440@2|Bacteria,1RAGN@1224|Proteobacteria,2U5CW@28211|Alphaproteobacteria,2JRQK@204441|Rhodospirillales	204441|Rhodospirillales	E	Acetolactate synthase small	ilvH	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C
k59_932979_2	42565.FP66_10280	2.4e-14	73.2	COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,1RNA8@1236|Gammaproteobacteria,1XIH7@135619|Oceanospirillales	135619|Oceanospirillales	EH	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
k59_987266_1	926550.CLDAP_29200	7.15e-15	81.3	COG1647@1|root,COG1647@2|Bacteria	2|Bacteria	M	Serine aminopeptidase, S33	-	-	3.1.1.1	ko:K03928	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_6,Hydrolase_4
k59_1486753_2	1247726.MIM_c15560	5.6e-42	143.0	COG2153@1|root,COG2153@2|Bacteria,1MZ86@1224|Proteobacteria,2VMR6@28216|Betaproteobacteria,3T4MR@506|Alcaligenaceae	28216|Betaproteobacteria	S	Histone acetyltransferase HPA2 and related acetyltransferases	yjcF	-	-	-	-	-	-	-	-	-	-	-	4HBT,Acetyltransf_10
k59_487222_1	266779.Meso_2140	2.51e-97	291.0	COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,2TR1H@28211|Alphaproteobacteria,43HIH@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
k59_1207763_1	926569.ANT_04250	1.02e-48	176.0	COG0303@1|root,COG1910@1|root,COG0303@2|Bacteria,COG1910@2|Bacteria,2G64H@200795|Chloroflexi	200795|Chloroflexi	K	PBP superfamily domain	-	-	2.10.1.1	ko:K03750,ko:K07219	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	HTH_3,MoCF_biosynth,MoeA_C,MoeA_N,PBP_like
k59_1207764_1	30611.ENSOGAP00000003666	0.000206	46.6	28KNG@1|root,2QT44@2759|Eukaryota,396DW@33154|Opisthokonta,3BB4R@33208|Metazoa,3CS3Y@33213|Bilateria,487HS@7711|Chordata,492UY@7742|Vertebrata,3J1MU@40674|Mammalia,35IUE@314146|Euarchontoglires,4MGUB@9443|Primates	33208|Metazoa	S	NNMT/PNMT/TEMT family	PNMT	GO:0001101,GO:0001666,GO:0003008,GO:0003674,GO:0003824,GO:0004603,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006575,GO:0006584,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0006950,GO:0007275,GO:0007600,GO:0007606,GO:0007610,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008757,GO:0009058,GO:0009116,GO:0009119,GO:0009266,GO:0009409,GO:0009410,GO:0009414,GO:0009415,GO:0009628,GO:0009636,GO:0009712,GO:0009713,GO:0009719,GO:0009725,GO:0009987,GO:0010033,GO:0010035,GO:0010243,GO:0014070,GO:0014823,GO:0016740,GO:0016741,GO:0017144,GO:0018958,GO:0019438,GO:0019752,GO:0030325,GO:0030424,GO:0030425,GO:0031960,GO:0032259,GO:0032501,GO:0032502,GO:0032868,GO:0032870,GO:0033267,GO:0033993,GO:0034641,GO:0035176,GO:0035270,GO:0035690,GO:0035900,GO:0035902,GO:0036293,GO:0036477,GO:0042221,GO:0042278,GO:0042414,GO:0042415,GO:0042418,GO:0042423,GO:0042493,GO:0042995,GO:0043005,GO:0043025,GO:0043195,GO:0043196,GO:0043204,GO:0043434,GO:0043436,GO:0043679,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044297,GO:0044304,GO:0044306,GO:0044424,GO:0044444,GO:0044456,GO:0044463,GO:0044464,GO:0045202,GO:0045471,GO:0045472,GO:0046128,GO:0046189,GO:0046483,GO:0046498,GO:0046500,GO:0046677,GO:0048513,GO:0048545,GO:0048731,GO:0048732,GO:0048856,GO:0050877,GO:0050896,GO:0050909,GO:0051186,GO:0051384,GO:0051703,GO:0051704,GO:0051705,GO:0051716,GO:0055086,GO:0070482,GO:0070848,GO:0070887,GO:0071310,GO:0071363,GO:0071375,GO:0071383,GO:0071384,GO:0071385,GO:0071396,GO:0071407,GO:0071417,GO:0071466,GO:0071495,GO:0071548,GO:0071549,GO:0071704,GO:0072521,GO:0097305,GO:0097327,GO:0097447,GO:0097458,GO:0098793,GO:0120025,GO:0120038,GO:0150034,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901615,GO:1901617,GO:1901652,GO:1901653,GO:1901654,GO:1901655,GO:1901657,GO:1901698,GO:1901699,GO:1901700,GO:1901701	2.1.1.1,2.1.1.28	ko:K00541,ko:K00553	ko00350,ko00760,ko01100,map00350,map00760,map01100	M00042	R01269,R02533	RC00003,RC00060,RC00484	ko00000,ko00001,ko00002,ko01000,ko03036	-	-	-	NNMT_PNMT_TEMT
k59_39621_1	861299.J421_1667	1.65e-23	104.0	COG0577@1|root,COG0577@2|Bacteria	861299.J421_1667|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_708993_1	118168.MC7420_8133	4.58e-108	329.0	COG3387@1|root,COG3387@2|Bacteria,1G3VS@1117|Cyanobacteria,1H860@1150|Oscillatoriales	1117|Cyanobacteria	G	Glycosyl hydrolases family 15	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_15
k59_1710157_1	1123400.KB904768_gene3408	5.94e-58	202.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,1RN6N@1236|Gammaproteobacteria,461JN@72273|Thiotrichales	72273|Thiotrichales	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_1540579_1	990285.RGCCGE502_06789	5.82e-06	55.5	COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,2TSF9@28211|Alphaproteobacteria,4B7PD@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
k59_261705_1	1122194.AUHU01000005_gene1101	8.63e-71	239.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,4643G@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	Methionine synthase	metH	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	iECO103_1326.ECO103_4764,iECUMN_1333.ECUMN_4545	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_429425_1	1267533.KB906736_gene1146	4.79e-36	140.0	COG0577@1|root,COG0577@2|Bacteria,3Y41Z@57723|Acidobacteria,2JI5N@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_873731_1	1267533.KB906733_gene3306	5.99e-12	66.6	COG2802@1|root,COG2802@2|Bacteria,3Y7JR@57723|Acidobacteria,2JMUX@204432|Acidobacteriia	204432|Acidobacteriia	S	ATP-dependent protease La (LON) substrate-binding domain	-	-	-	ko:K07157	-	-	-	-	ko00000	-	-	-	LON_substr_bdg
k59_873731_2	309801.trd_1572	1.52e-26	107.0	COG1012@1|root,COG1012@2|Bacteria,2G5JZ@200795|Chloroflexi,27Y57@189775|Thermomicrobia	189775|Thermomicrobia	C	Belongs to the aldehyde dehydrogenase family	-	-	-	ko:K22187	ko00040,map00040	-	R11768	RC00080	ko00000,ko00001,ko01000	-	-	-	Aldedh
k59_374023_1	1168034.FH5T_01630	2.2e-84	257.0	COG0437@1|root,COG0437@2|Bacteria,4NIEP@976|Bacteroidetes	976|Bacteroidetes	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_11,Fer4_4
k59_1375535_2	1128421.JAGA01000002_gene1845	4.27e-55	181.0	COG0623@1|root,COG0623@2|Bacteria	2|Bacteria	I	enoyl-[acyl-carrier-protein] reductase (NADH) activity	fabI	GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0030497,GO:0032787,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:1901576	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_429431_1	671143.DAMO_2608	4.12e-27	112.0	COG0558@1|root,COG0558@2|Bacteria	2|Bacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	-	-	-	-	-	-	-	-	-	-	CDP-OH_P_transf
k59_1207782_1	269084.syc1032_d	1.45e-26	104.0	COG0681@1|root,COG0681@2|Bacteria,1G54H@1117|Cyanobacteria,1GZ4P@1129|Synechococcus	1117|Cyanobacteria	U	Belongs to the peptidase S26 family	lepB2	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
k59_1486775_1	1042377.AFPJ01000051_gene35	1.81e-43	157.0	28HC9@1|root,2Z7P5@2|Bacteria,1R4BH@1224|Proteobacteria,1RSAN@1236|Gammaproteobacteria,4642U@72275|Alteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_818797_1	1122176.KB903532_gene2710	9.4e-67	231.0	COG1629@1|root,COG4771@2|Bacteria,4NDU8@976|Bacteroidetes,1INX1@117747|Sphingobacteriia	976|Bacteroidetes	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
k59_595887_1	641147.HMPREF9021_00346	4.56e-21	89.4	COG0494@1|root,COG0494@2|Bacteria,1RCX7@1224|Proteobacteria,2VRU5@28216|Betaproteobacteria,2KR33@206351|Neisseriales	206351|Neisseriales	L	Psort location Cytoplasmic, score 8.96	mutT	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
k59_1430377_1	1121935.AQXX01000132_gene2624	4.88e-90	278.0	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,1RMN6@1236|Gammaproteobacteria,1XHSI@135619|Oceanospirillales	135619|Oceanospirillales	P	Trk system potassium uptake protein	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
k59_818807_1	314287.GB2207_05192	3.61e-78	247.0	COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,1RPM2@1236|Gammaproteobacteria,1J4Z9@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins	dnaB	GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0032392,GO:0032508,GO:0034641,GO:0034645,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
k59_487270_2	1168034.FH5T_07025	2.37e-48	176.0	COG3250@1|root,COG3250@2|Bacteria,4NF3W@976|Bacteroidetes,2FM0P@200643|Bacteroidia	976|Bacteroidetes	G	beta-galactosidase	-	-	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	Bgal_small_N,DUF4981,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
k59_1489382_2	489825.LYNGBM3L_22490	8.83e-28	117.0	COG0578@1|root,COG0578@2|Bacteria,1G1T3@1117|Cyanobacteria,1H86N@1150|Oscillatoriales	1117|Cyanobacteria	C	FAD dependent oxidoreductase	-	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C
k59_935431_1	395494.Galf_2689	6.37e-79	249.0	COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,2VKNG@28216|Betaproteobacteria,44UYU@713636|Nitrosomonadales	28216|Betaproteobacteria	J	S-adenosylmethionine-dependent methyltransferase	rlmI	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
k59_1210142_1	1122201.AUAZ01000032_gene1600	4.89e-66	208.0	COG0284@1|root,COG0284@2|Bacteria,1MW2C@1224|Proteobacteria,1RNJR@1236|Gammaproteobacteria,464PB@72275|Alteromonadaceae	1236|Gammaproteobacteria	F	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)	pyrF	GO:0003674,GO:0003824,GO:0004590,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	iECO103_1326.ECO103_1444,iECSF_1327.ECSF_1264,iSFV_1184.SFV_1294,iSF_1195.SF1285,iSFxv_1172.SFxv_1457,iS_1188.S1368,ic_1306.c1750	OMPdecase
k59_1653007_2	926569.ANT_08730	1.38e-47	169.0	COG0751@1|root,COG0752@1|root,COG0751@2|Bacteria,COG0752@2|Bacteria,2G7V0@200795|Chloroflexi	200795|Chloroflexi	J	Glycyl-tRNA synthetase alpha subunit	glyQS	-	6.1.1.14	ko:K14164	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	tRNA-synt_2e,tRNA_synt_2f
k59_876215_1	1121930.AQXG01000010_gene3060	2.87e-96	310.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,4NGU2@976|Bacteroidetes,1IR3P@117747|Sphingobacteriia	976|Bacteroidetes	M	Tricorn protease homolog	-	-	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
k59_153422_1	1094980.Mpsy_3179	5.15e-26	104.0	COG2386@1|root,arCOG01328@2157|Archaea,2XTAS@28890|Euryarchaeota,2NAJD@224756|Methanomicrobia	224756|Methanomicrobia	O	CcmB protein	-	-	-	ko:K02194	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	CcmB
k59_652272_1	1121904.ARBP01000008_gene3346	2.64e-19	93.2	COG2091@1|root,COG2091@2|Bacteria,4NFQ6@976|Bacteroidetes,47MUU@768503|Cytophagia	976|Bacteroidetes	H	Carbohydrate family 9 binding domain-like	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
k59_1600150_1	931627.MycrhDRAFT_6556	5.4e-68	217.0	COG2141@1|root,COG2141@2|Bacteria,2H0K9@201174|Actinobacteria,236R5@1762|Mycobacteriaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_41892_1	1197477.IA57_06200	3.17e-107	326.0	COG0449@1|root,COG0449@2|Bacteria,4NE8Q@976|Bacteroidetes,1HX0U@117743|Flavobacteriia	976|Bacteroidetes	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
k59_1489440_1	608538.HTH_0825	7.92e-44	155.0	COG1694@1|root,COG3956@2|Bacteria,2G3T8@200783|Aquificae	200783|Aquificae	S	TIGRFAM MazG family protein	mazG	-	-	ko:K02499	-	-	-	-	ko00000,ko03036	-	-	-	MazG
k59_1155492_1	1313172.YM304_14970	8.12e-08	52.4	COG0164@1|root,COG0164@2|Bacteria,2GJFN@201174|Actinobacteria,4CN9Z@84992|Acidimicrobiia	84992|Acidimicrobiia	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	-	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
k59_652307_1	1121085.AUCI01000001_gene3530	8.58e-51	176.0	COG2828@1|root,COG2828@2|Bacteria,1TPP6@1239|Firmicutes,4HD7I@91061|Bacilli,1ZBED@1386|Bacillus	91061|Bacilli	S	PrpF protein	yraM	-	-	-	-	-	-	-	-	-	-	-	PrpF
k59_263836_1	485913.Krac_1655	6.09e-51	171.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	ko:K07494	-	-	-	-	ko00000	-	-	-	DDE_3,HTH_23,HTH_32,HTH_33
k59_989734_1	379066.GAU_3378	5.51e-42	147.0	2DCAE@1|root,2ZDF3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_989741_1	384765.SIAM614_29071	2.39e-67	214.0	COG4177@1|root,COG4177@2|Bacteria,1NY9G@1224|Proteobacteria,2TTSN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_989741_2	1410620.SHLA_70c000060	1.2e-40	141.0	COG0559@1|root,COG0559@2|Bacteria,1P3FU@1224|Proteobacteria,2U0D7@28211|Alphaproteobacteria,4B8KN@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
k59_1764543_1	459495.SPLC1_S570310	1.16e-27	109.0	COG4803@1|root,COG4803@2|Bacteria,1GA6S@1117|Cyanobacteria,1HEWV@1150|Oscillatoriales	1117|Cyanobacteria	S	Protein of unknown function (DUF1269)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1269
k59_543035_1	1242864.D187_007915	3.89e-08	59.7	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
k59_821189_1	313598.MED152_05570	3.26e-37	139.0	COG0770@1|root,COG0770@2|Bacteria,4NDWD@976|Bacteroidetes,1HY7Q@117743|Flavobacteriia,3VVIA@52959|Polaribacter	976|Bacteroidetes	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_1046041_1	1247963.JPHU01000007_gene1600	6.9e-80	253.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,2TSR0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Phytoene dehydrogenase	crtI	-	1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31,5.2.1.13	ko:K09835,ko:K10027	ko00906,ko01100,ko01110,map00906,map01100,map01110	M00097	R04787,R04798,R04800,R07512,R09691,R09692	RC01214,RC01960,RC02088,RC02605	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
k59_98532_1	926569.ANT_25740	5.05e-49	176.0	COG0863@1|root,COG0863@2|Bacteria	2|Bacteria	L	N-4 methylation of cytosine	-	-	2.1.1.113	ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	-
k59_489664_1	1286093.C266_23543	8.94e-74	238.0	COG2072@1|root,COG2072@2|Bacteria,1MUKW@1224|Proteobacteria,2VJ50@28216|Betaproteobacteria,1K05D@119060|Burkholderiaceae	28216|Betaproteobacteria	P	FAD-NAD(P)-binding	-	-	-	-	-	-	-	-	-	-	-	-	K_oxygenase,Pyr_redox_3
k59_1046045_1	1165841.SULAR_08667	1.31e-12	66.6	COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,42NAA@68525|delta/epsilon subdivisions,2YMYI@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	-	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
k59_1046045_2	992406.RIA_1159	1.18e-29	113.0	COG0020@1|root,COG0020@2|Bacteria,4NF2B@976|Bacteroidetes,1HXRP@117743|Flavobacteriia	976|Bacteroidetes	I	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
k59_935579_1	1168034.FH5T_10880	1.58e-42	156.0	COG0028@1|root,COG0028@2|Bacteria,4NENG@976|Bacteroidetes,2FMMH@200643|Bacteroidia	976|Bacteroidetes	H	acetolactate synthase	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_764967_1	530564.Psta_4545	3.33e-10	59.7	COG0377@1|root,COG0377@2|Bacteria,2IY3F@203682|Planctomycetes	203682|Planctomycetes	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
k59_764967_2	1284679.HMPREF1626_08345	4.01e-22	91.3	COG0838@1|root,COG0838@2|Bacteria,2IKWT@201174|Actinobacteria,4D5TE@85005|Actinomycetales	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoA	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0055114,GO:0098796,GO:1902494	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
k59_1155592_2	926560.KE387023_gene3374	7.73e-45	152.0	COG2318@1|root,COG2318@2|Bacteria	2|Bacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
k59_1155592_3	1144275.COCOR_01063	2.2e-25	103.0	COG0596@1|root,COG0596@2|Bacteria,1QVBQ@1224|Proteobacteria	1224|Proteobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_42003_1	713586.KB900536_gene575	1.04e-26	102.0	2EJUZ@1|root,33DJM@2|Bacteria,1NIYD@1224|Proteobacteria,1SGV4@1236|Gammaproteobacteria,1WZJR@135613|Chromatiales	135613|Chromatiales	S	Putative prokaryotic signal transducing protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2007
k59_42003_2	272134.KB731324_gene6043	3.88e-32	114.0	COG3805@1|root,COG3805@2|Bacteria,1G7MF@1117|Cyanobacteria,1HFX2@1150|Oscillatoriales	1117|Cyanobacteria	Q	Dopa 4,5-dioxygenase family	-	-	-	ko:K10253	-	-	-	-	ko00000,ko01000	-	-	-	DOPA_dioxygen
k59_1046059_1	1207058.L53_15670	6.03e-31	123.0	COG0845@1|root,COG0845@2|Bacteria,1Q10W@1224|Proteobacteria,2TSC8@28211|Alphaproteobacteria,43ZAU@69657|Hyphomonadaceae	28211|Alphaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_3
k59_1268732_1	861299.J421_0057	1.22e-24	97.8	COG0782@1|root,COG0782@2|Bacteria,1ZTPD@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Transcription elongation factor, N-terminal	-	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
k59_1228869_2	1267534.KB906756_gene142	9.47e-40	142.0	COG0821@1|root,COG0821@2|Bacteria,3Y2GU@57723|Acidobacteria,2JHND@204432|Acidobacteriia	204432|Acidobacteriia	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
k59_560994_1	216432.CA2559_06995	6.99e-25	100.0	COG2323@1|root,COG2323@2|Bacteria,4NR3N@976|Bacteroidetes,1IIDW@117743|Flavobacteriia	976|Bacteroidetes	S	Protein of unknown function (DUF421)	-	-	-	-	-	-	-	-	-	-	-	-	DUF421
k59_1561858_1	1117958.PE143B_0129225	3.28e-58	193.0	COG3566@1|root,COG3566@2|Bacteria,1RDHK@1224|Proteobacteria,1S79H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2213)	-	-	-	ko:K09960	-	-	-	-	ko00000	-	-	-	DUF2213
k59_338611_1	1282876.BAOK01000002_gene460	1.38e-42	146.0	COG0176@1|root,COG0176@2|Bacteria,1MWQ8@1224|Proteobacteria,2TQJB@28211|Alphaproteobacteria,4BPKX@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	H	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	GO:0003674,GO:0003824,GO:0006002,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016830,GO:0016832,GO:0019637,GO:0044237,GO:0071704,GO:1901135	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
k59_1117428_1	1459636.NTE_01618	9.67e-46	150.0	COG1310@1|root,arCOG01139@2157|Archaea,41SQ7@651137|Thaumarchaeota	651137|Thaumarchaeota	S	metal-dependent protease of the PAD1 JAB1 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Prok-JAB
k59_5463_1	314345.SPV1_03243	1.6e-06	49.7	COG2304@1|root,COG2304@2|Bacteria,1MW51@1224|Proteobacteria	1224|Proteobacteria	M	protein containing a von Willebrand factor type A (vWA) domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	TPR_1,TPR_2,VWA_2
k59_5463_2	377629.TERTU_2435	3.43e-19	90.9	COG0457@1|root,COG0457@2|Bacteria,1MXK4@1224|Proteobacteria,1RNFM@1236|Gammaproteobacteria,2PNC1@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	S	Oxygen tolerance	batD	-	-	-	-	-	-	-	-	-	-	-	BatD
k59_227719_1	991905.SL003B_2525	4.63e-78	249.0	COG1053@1|root,COG1053@2|Bacteria,1MURY@1224|Proteobacteria,2TSRQ@28211|Alphaproteobacteria,4BRHP@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2
k59_561011_1	1121033.AUCF01000006_gene4295	8.47e-72	242.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,2TR7W@28211|Alphaproteobacteria,2JQIV@204441|Rhodospirillales	204441|Rhodospirillales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
k59_1673133_1	1210884.HG799465_gene11610	1.93e-14	72.0	COG2808@1|root,COG2808@2|Bacteria,2IYVC@203682|Planctomycetes	203682|Planctomycetes	K	Transcriptional regulator	-	-	-	ko:K07734	-	-	-	-	ko00000,ko03000	-	-	-	FMN_bind_2
k59_1673133_2	89187.ISM_12020	1.72e-11	60.5	COG3791@1|root,COG3791@2|Bacteria,1N031@1224|Proteobacteria,2UC7G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Glutathione-dependent formaldehyde-activating	-	-	-	-	-	-	-	-	-	-	-	-	GFA
k59_1283963_1	251221.35211248	1.26e-36	129.0	COG1695@1|root,COG1695@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	-	-	-	-	-	-	-	-	-	PadR
k59_1450967_1	305900.GV64_20025	2.11e-24	98.6	COG0625@1|root,COG0625@2|Bacteria,1RD7K@1224|Proteobacteria,1S42S@1236|Gammaproteobacteria,1XPCN@135619|Oceanospirillales	135619|Oceanospirillales	O	Glutathione S-transferase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	GST_C_2,GST_N_3
k59_1450967_2	589865.DaAHT2_2453	1.01e-30	120.0	COG0471@1|root,COG3273@1|root,COG0471@2|Bacteria,COG3273@2|Bacteria,1MU0K@1224|Proteobacteria,42MR7@68525|delta/epsilon subdivisions,2WIKA@28221|Deltaproteobacteria,2MMR4@213118|Desulfobacterales	28221|Deltaproteobacteria	P	PFAM Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,Na_sulph_symp,TrkA_C
k59_505734_1	571166.KI421509_gene2288	6.86e-71	226.0	COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,2U0EE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
k59_1506261_1	215803.DB30_5880	4.85e-57	200.0	COG2132@1|root,COG2132@2|Bacteria,1N9H3@1224|Proteobacteria,42Z37@68525|delta/epsilon subdivisions,2WUNE@28221|Deltaproteobacteria,2YZFR@29|Myxococcales	28221|Deltaproteobacteria	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1172735_1	207954.MED92_03957	4.07e-50	181.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,1XIHW@135619|Oceanospirillales	135619|Oceanospirillales	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topo_Zn_Ribbon,Topoisom_bac,Toprim,zf-C4_Topoisom
k59_450226_1	45351.EDO48725	4.43e-53	179.0	COG0620@1|root,KOG2263@2759|Eukaryota,38GZS@33154|Opisthokonta,3BNKS@33208|Metazoa	33208|Metazoa	E	Cobalamin-independent synthase, Catalytic domain	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
k59_1228935_1	1120970.AUBZ01000029_gene1055	4.72e-30	120.0	COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,1RNGY@1236|Gammaproteobacteria,465T8@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.7.1.15	ko:K00362	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_BFD,Pyr_redox_2
k59_1228935_2	1121935.AQXX01000139_gene3014	5.21e-12	66.2	COG3303@1|root,COG3303@2|Bacteria,1R5JF@1224|Proteobacteria,1S13K@1236|Gammaproteobacteria,1XNJE@135619|Oceanospirillales	135619|Oceanospirillales	C	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_c3_2
k59_1561909_1	438753.AZC_3631	7.04e-89	278.0	COG0166@1|root,COG0166@2|Bacteria,1MUFP@1224|Proteobacteria,2TQKP@28211|Alphaproteobacteria,3EYXB@335928|Xanthobacteraceae	28211|Alphaproteobacteria	G	Phosphoglucose isomerase	pgi	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
k59_116396_1	996637.SGM_6525	3.15e-32	123.0	COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria	201174|Actinobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_1506288_1	1001240.GY21_08125	1.41e-10	66.2	COG0406@1|root,COG0406@2|Bacteria,2GK8N@201174|Actinobacteria,4FKKE@85023|Microbacteriaceae	201174|Actinobacteria	G	Phosphoglycerate mutase family	-	-	5.4.2.11	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
k59_672608_1	84531.JMTZ01000056_gene2546	1.99e-08	60.5	COG3202@1|root,COG3202@2|Bacteria,1MVP5@1224|Proteobacteria,1RNY6@1236|Gammaproteobacteria,1X4WT@135614|Xanthomonadales	135614|Xanthomonadales	C	Major Facilitator Superfamily	-	-	-	ko:K03301	-	-	-	-	ko00000	2.A.12	-	-	MFS_1,TLC
k59_839100_1	1150600.ADIARSV_1171	2.97e-41	157.0	COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria,4NERT@976|Bacteroidetes,1IPI7@117747|Sphingobacteriia	976|Bacteroidetes	MU	Periplasmic component of the Tol biopolymer transport system	-	-	-	-	-	-	-	-	-	-	-	-	BSP,PD40,Peptidase_MA_2
k59_172114_1	1232410.KI421421_gene3632	2.69e-101	303.0	COG0656@1|root,COG0656@2|Bacteria	2|Bacteria	S	aldo-keto reductase (NADP) activity	-	-	1.1.1.65	ko:K05275	ko00750,ko01100,ko01120,map00750,map01100,map01120	-	R01708	RC00116	ko00000,ko00001,ko01000	-	-	-	Aldo_ket_red
k59_1451026_2	351016.RAZWK3B_16705	8.76e-70	221.0	28MVD@1|root,2ZB2Y@2|Bacteria,1R8NK@1224|Proteobacteria,2U265@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF4043)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4043
k59_1728707_1	485913.Krac_9327	7.68e-12	66.2	COG3547@1|root,COG3547@2|Bacteria	2|Bacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1728707_2	742735.HMPREF9467_04258	9.2e-10	65.5	COG3547@1|root,COG3547@2|Bacteria,1TQP6@1239|Firmicutes,248VD@186801|Clostridia,21ZH2@1506553|Lachnoclostridium	186801|Clostridia	L	transposase IS116 IS110 IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1673205_1	118166.JH976537_gene1430	2.08e-09	65.1	COG0491@1|root,COG0491@2|Bacteria,1G455@1117|Cyanobacteria,1HDSU@1150|Oscillatoriales	1117|Cyanobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_1673211_1	1313172.YM304_10310	1.55e-70	227.0	COG0019@1|root,COG0019@2|Bacteria,2GKAI@201174|Actinobacteria,4CMVX@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
k59_895088_1	585531.HMPREF0063_12660	2.8e-22	98.6	COG0642@1|root,COG2205@2|Bacteria,2I3JI@201174|Actinobacteria,4DPJI@85009|Propionibacteriales	201174|Actinobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
k59_1728727_1	562970.Btus_0349	1.09e-42	156.0	COG1804@1|root,COG1804@2|Bacteria,1TP54@1239|Firmicutes,4HABI@91061|Bacilli,279GP@186823|Alicyclobacillaceae	91061|Bacilli	C	CoA-transferase family III	-	-	2.8.3.19	ko:K18702	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
k59_1229008_1	313612.L8106_26162	2.73e-49	172.0	COG3635@1|root,COG3635@2|Bacteria,1G24J@1117|Cyanobacteria,1H9EU@1150|Oscillatoriales	1117|Cyanobacteria	G	2,3-bisphosphoglycerate-independent phosphoglycerate mutase	-	-	-	-	-	-	-	-	-	-	-	-	Metalloenzyme,PhosphMutase
k59_728332_1	518766.Rmar_1420	1.44e-119	355.0	COG1228@1|root,COG1228@2|Bacteria,4P0AG@976|Bacteroidetes,1FJ21@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_1339671_1	861299.J421_0393	9.96e-27	113.0	COG0577@1|root,COG0577@2|Bacteria	861299.J421_0393|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1229010_1	68260.JOAY01000058_gene5401	6.52e-22	90.5	COG4405@1|root,COG4405@2|Bacteria,2IKQP@201174|Actinobacteria	201174|Actinobacteria	I	ASCH	-	-	-	-	-	-	-	-	-	-	-	-	ASCH
k59_1229010_2	479434.Sthe_2591	9.59e-38	140.0	COG0665@1|root,COG0665@2|Bacteria,2G6HT@200795|Chloroflexi,27XXT@189775|Thermomicrobia	189775|Thermomicrobia	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
k59_172150_1	765911.Thivi_2106	8.71e-28	116.0	COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,1RPSJ@1236|Gammaproteobacteria,1WX1A@135613|Chromatiales	135613|Chromatiales	T	Putative nucleotidyltransferase substrate binding domain	-	-	-	ko:K07182	-	-	-	-	ko00000	-	-	-	CBS,DUF294,DUF294_C,cNMP_binding
k59_1561987_1	697282.Mettu_1553	8.65e-90	289.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,1RMTF@1236|Gammaproteobacteria,1XDWG@135618|Methylococcales	135618|Methylococcales	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
k59_1174079_1	926550.CLDAP_02410	6.28e-35	126.0	COG3335@1|root,COG3335@2|Bacteria,2G9RC@200795|Chloroflexi	200795|Chloroflexi	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
k59_340011_1	298655.KI912266_gene2181	9.51e-41	147.0	COG1741@1|root,COG1741@2|Bacteria,2GM9P@201174|Actinobacteria,4ETSB@85013|Frankiales	201174|Actinobacteria	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
k59_62266_1	1151126.AQYI01000006_gene2785	2e-06	49.3	COG0745@1|root,COG0745@2|Bacteria,2ICPT@201174|Actinobacteria,4FNNU@85023|Microbacteriaceae	201174|Actinobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
k59_62266_2	880073.Calab_2008	2.53e-14	77.0	COG2189@1|root,COG2189@2|Bacteria,2NP0F@2323|unclassified Bacteria	2|Bacteria	L	PFAM DNA methylase N-4 N-6	-	-	2.1.1.72	ko:K00571,ko:K07316	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
k59_507076_1	243230.DR_2211	3.54e-38	138.0	COG0566@1|root,COG0566@2|Bacteria,1WID3@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	J	Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA	trmH	GO:0001510,GO:0002128,GO:0002938,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008175,GO:0008757,GO:0009020,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0106050,GO:0140098,GO:0140101,GO:1901360	2.1.1.34	ko:K00556	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylas_C,SpoU_methylase
k59_840399_2	926569.ANT_14410	5.61e-66	207.0	COG1478@1|root,COG1478@2|Bacteria,2G5TU@200795|Chloroflexi	200795|Chloroflexi	S	TIGRFAM F420-dependent oxidoreductase	-	-	6.3.2.31,6.3.2.34	ko:K12234	ko00680,ko01120,map00680,map01120	M00378	R09399,R09400	RC00064,RC00090,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_ligase
k59_1062859_1	195250.CM001776_gene2865	3.91e-91	278.0	COG3385@1|root,COG3385@2|Bacteria,1G2YX@1117|Cyanobacteria	1117|Cyanobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
k59_507093_1	1121935.AQXX01000120_gene4836	2.16e-35	137.0	COG5001@1|root,COG5001@2|Bacteria,1PV95@1224|Proteobacteria,1RRN3@1236|Gammaproteobacteria,1XN5V@135619|Oceanospirillales	135619|Oceanospirillales	T	7TM diverse intracellular signalling	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,EAL,GGDEF
k59_507093_2	522306.CAP2UW1_0327	4.12e-21	95.9	2B4YM@1|root,31XRK@2|Bacteria,1MY6A@1224|Proteobacteria,2VUKQ@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF2894)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2894
k59_62288_1	926569.ANT_13950	0.000665	41.2	COG4191@1|root,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	GGDEF,PAS,PilZ
k59_62288_2	228405.HNE_3497	8.29e-37	143.0	COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,2TTRU@28211|Alphaproteobacteria,43WFY@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	metal-dependent hydrolase with the TIM-barrel fold	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_896426_2	1123248.KB893337_gene2427	8.3e-24	100.0	COG0697@1|root,COG0697@2|Bacteria,4NGJR@976|Bacteroidetes,1IPGU@117747|Sphingobacteriia	976|Bacteroidetes	EG	PFAM EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_674012_1	323848.Nmul_A1023	3.24e-147	437.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,2VJ2J@28216|Betaproteobacteria,373U8@32003|Nitrosomonadales	28216|Betaproteobacteria	C	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus	-	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
k59_951885_1	1121948.AUAC01000004_gene49	2.14e-11	63.2	COG0730@1|root,COG0730@2|Bacteria,1MVY3@1224|Proteobacteria,2TU6M@28211|Alphaproteobacteria,43ZSE@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
k59_951885_2	1141663.OOC_19102	1.06e-86	265.0	COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,1RRPI@1236|Gammaproteobacteria,3Z8CS@586|Providencia	1236|Gammaproteobacteria	C	Psort location Cytoplasmic, score	yeaU	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003862,GO:0005488,GO:0006082,GO:0006108,GO:0008150,GO:0008152,GO:0009027,GO:0009987,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0019752,GO:0036094,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044281,GO:0046553,GO:0046872,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363	1.1.1.83,1.1.1.93,4.1.1.73	ko:K07246	ko00630,ko00650,map00630,map00650	-	R00215,R01751,R02545,R06180	RC00084,RC00105,RC00594	ko00000,ko00001,ko01000	-	-	iSBO_1134.SBO_1288	Iso_dh
k59_1730069_1	40571.JOEA01000007_gene6729	2.33e-06	50.8	COG1366@1|root,COG1366@2|Bacteria,2GUSD@201174|Actinobacteria,4E73D@85010|Pseudonocardiales	201174|Actinobacteria	T	STAS domain	-	-	-	-	-	-	-	-	-	-	-	-	STAS,STAS_2
k59_1674531_1	570967.JMLV01000012_gene3205	3.75e-11	67.4	COG0318@1|root,COG0318@2|Bacteria,1PUY0@1224|Proteobacteria,2U1K6@28211|Alphaproteobacteria,2JQ3F@204441|Rhodospirillales	204441|Rhodospirillales	IQ	GH3 auxin-responsive promoter	-	-	-	-	-	-	-	-	-	-	-	-	GH3
k59_674020_1	1122221.JHVI01000014_gene1396	1.1e-70	219.0	COG0262@1|root,COG0262@2|Bacteria	2|Bacteria	H	dihydrofolate reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
k59_1563324_1	555779.Dthio_PD3239	1.65e-58	201.0	COG1614@1|root,COG1614@2|Bacteria,1MVI5@1224|Proteobacteria,42N9A@68525|delta/epsilon subdivisions,2WK4H@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM CO dehydrogenase acetyl-CoA synthase complex beta subunit	-	-	2.3.1.169	ko:K14138	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00377	R08433,R10243	RC00004,RC00113,RC01144,RC02963,RC02964,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhC
k59_451666_1	1380394.JADL01000002_gene1729	2.73e-35	137.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2TQVK@28211|Alphaproteobacteria,2JUZD@204441|Rhodospirillales	204441|Rhodospirillales	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C2
k59_1674539_1	1123508.JH636455_gene36	4.37e-05	49.7	COG0515@1|root,COG0515@2|Bacteria,2IXXT@203682|Planctomycetes	203682|Planctomycetes	KLT	Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
k59_395855_1	555793.WSK_2670	0.000593	50.4	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,2TRFB@28211|Alphaproteobacteria,2K05M@204457|Sphingomonadales	204457|Sphingomonadales	S	Peptidase, M16	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_951916_1	1123073.KB899245_gene94	9.06e-66	213.0	COG4638@1|root,COG4638@2|Bacteria,1MWXW@1224|Proteobacteria,1S9NJ@1236|Gammaproteobacteria,1X5C8@135614|Xanthomonadales	135614|Xanthomonadales	P	COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit	-	-	1.14.12.1	ko:K16319	ko00627,ko01120,map00627,map01120	M00637	R00823,R00825	RC00192	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske,Ring_hydroxyl_A
k59_785038_2	1340434.AXVA01000003_gene1556	4.3e-110	338.0	COG1123@1|root,COG4172@2|Bacteria,1UZK8@1239|Firmicutes,4HTUD@91061|Bacilli,1ZSDT@1386|Bacillus	91061|Bacilli	P	Oligopeptide/dipeptide transporter, C-terminal region	oppF	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_284806_2	485918.Cpin_1365	4.84e-10	63.2	COG0392@1|root,COG0392@2|Bacteria	2|Bacteria	M	lysyltransferase activity	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
k59_1396602_1	1267535.KB906767_gene5149	5.23e-06	48.9	COG1652@1|root,COG1652@2|Bacteria,3Y84E@57723|Acidobacteria	57723|Acidobacteria	S	Lysin motif	-	-	-	-	-	-	-	-	-	-	-	-	LysM
k59_799932_1	374847.Kcr_1186	8.55e-40	146.0	COG0404@1|root,arCOG00756@2157|Archaea	2157|Archaea	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
k59_132062_1	460265.Mnod_1906	1.44e-77	241.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,2TQP8@28211|Alphaproteobacteria,1JQRM@119045|Methylobacteriaceae	28211|Alphaproteobacteria	J	GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
k59_1467049_1	1266925.JHVX01000004_gene1249	4.27e-62	213.0	COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,2VJYV@28216|Betaproteobacteria,373XN@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdop_Fe4S4,Molybdopterin,NADH-G_4Fe-4S_3
k59_521873_1	28229.ND2E_4229	2.66e-86	283.0	COG3250@1|root,COG3250@2|Bacteria,1MVBN@1224|Proteobacteria,1RMER@1236|Gammaproteobacteria,2Q7DS@267889|Colwelliaceae	1236|Gammaproteobacteria	G	Beta galactosidase small chain	-	-	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	Bgal_small_N,DUF4981,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
k59_243718_1	1288826.MSNKSG1_13877	2.25e-06	48.9	COG1309@1|root,COG1309@2|Bacteria,1MUJ5@1224|Proteobacteria,1T10H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_243718_2	1288826.MSNKSG1_13892	5.34e-66	210.0	COG1902@1|root,COG1902@2|Bacteria,1MVIX@1224|Proteobacteria,1RMFI@1236|Gammaproteobacteria,464MK@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
k59_1188872_1	883.DvMF_1527	2.57e-05	47.4	28Q1P@1|root,2ZCJY@2|Bacteria,1RCE9@1224|Proteobacteria,42R28@68525|delta/epsilon subdivisions,2WN78@28221|Deltaproteobacteria,2MBBP@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Zinc dependent phospholipase C	-	-	-	-	-	-	-	-	-	-	-	-	Zn_dep_PLPC
k59_1632716_1	1003200.AXXA_06208	1.92e-15	81.3	COG0028@1|root,COG0028@2|Bacteria,1MX3Q@1224|Proteobacteria,2VMUI@28216|Betaproteobacteria,3T2PP@506|Alcaligenaceae	28216|Betaproteobacteria	EH	Thiamine pyrophosphate enzyme, central domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_966737_1	314285.KT71_02522	6.03e-73	241.0	COG1913@1|root,COG1913@2|Bacteria,1MY52@1224|Proteobacteria,1RSIP@1236|Gammaproteobacteria,1J4I2@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF5117)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4953,DUF5117
k59_1300111_1	743719.PaelaDRAFT_4489	2.78e-35	132.0	COG1131@1|root,COG1131@2|Bacteria,1TQEV@1239|Firmicutes,4HBHF@91061|Bacilli,26SXK@186822|Paenibacillaceae	91061|Bacilli	V	ABC transporter, ATP-binding protein	yxlF	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
k59_1022774_1	494419.ALPM01000100_gene1050	5.65e-66	210.0	arCOG06481@1|root,2ZB4E@2|Bacteria,2I95D@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_521887_1	1267534.KB906759_gene1728	5.73e-11	62.4	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,3Y3NX@57723|Acidobacteria,2JKIA@204432|Acidobacteriia	2|Bacteria	C	Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg	porA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iLJ478.TM1164	PFOR_II,POR,POR_N,Transketolase_C
k59_521887_2	935866.JAER01000008_gene1016	8.94e-23	90.9	COG1146@1|root,COG1146@2|Bacteria,2IKVN@201174|Actinobacteria,4DR37@85009|Propionibacteriales	201174|Actinobacteria	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	fdxA	-	-	-	-	-	-	-	-	-	-	-	Fer4
k59_243749_1	450851.PHZ_p0142	5.54e-83	261.0	COG0213@1|root,COG0213@2|Bacteria,1MV3H@1224|Proteobacteria,2TS24@28211|Alphaproteobacteria,2KJGW@204458|Caulobacterales	204458|Caulobacterales	F	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis	-	-	2.4.2.4	ko:K00758	ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219	-	R01570,R02484,R08222,R08230	RC00063	ko00000,ko00001,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
k59_799987_1	94122.Shewana3_0245	3.99e-12	65.5	COG3658@1|root,COG3658@2|Bacteria,1RIG7@1224|Proteobacteria,1S4KI@1236|Gammaproteobacteria,2QB8E@267890|Shewanellaceae	1236|Gammaproteobacteria	C	PFAM cytochrome B561	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
k59_76870_1	485913.Krac_11199	1.29e-59	207.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,2G5Y6@200795|Chloroflexi	200795|Chloroflexi	H	Methionine synthase B12-binding module cap domain protein	-	-	2.1.1.13,2.1.1.258	ko:K00548,ko:K15023	ko00270,ko00450,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01230,map00270,map00450,map00670,map00720,map01100,map01110,map01120,map01200,map01230	M00017,M00377	R00946,R02289,R09365,R10243	RC00004,RC00035,RC00113,RC01144,RC01241,RC02871,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_187884_1	936455.KI421499_gene6958	7.44e-79	245.0	COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,2TR0J@28211|Alphaproteobacteria,3JSG0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EP	Belongs to the ABC transporter superfamily	MA20_22935	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_799999_1	300852.55773313	3.32e-32	120.0	COG0723@1|root,COG0723@2|Bacteria,1WJBT@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	PFAM Rieske 2Fe-2S domain	-	-	-	ko:K15878	-	-	-	-	ko00000	-	-	-	Rieske
k59_799999_2	1038866.KB902796_gene7404	8.8e-09	57.0	COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TS2Q@28211|Alphaproteobacteria,3JSFY@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	PQQ-like domain	MA20_34345	-	1.1.2.8	ko:K00114	ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130	-	R05062,R05198,R05285	RC00087,RC00088,RC01039	ko00000,ko00001,ko01000	-	-	-	PQQ,PQQ_2
k59_966787_1	580327.Tthe_2694	8.36e-107	323.0	COG3547@1|root,COG3547@2|Bacteria,1TQP6@1239|Firmicutes,248VD@186801|Clostridia,42FT8@68295|Thermoanaerobacterales	186801|Clostridia	L	Transposase IS116 IS110 IS902 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_854380_1	504487.JCM19302_3553	3.7e-48	170.0	COG1228@1|root,COG1228@2|Bacteria,4NFI3@976|Bacteroidetes,1HY2V@117743|Flavobacteriia	976|Bacteroidetes	Q	Imidazolonepropionase and related	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_1022826_2	1123508.JH636445_gene6824	1.88e-31	125.0	COG4805@1|root,COG4805@2|Bacteria,2IXQZ@203682|Planctomycetes	203682|Planctomycetes	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
k59_467097_1	926550.CLDAP_39510	1.25e-83	260.0	COG1350@1|root,COG1350@2|Bacteria,2G5YY@200795|Chloroflexi	200795|Chloroflexi	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	-	-	4.2.1.20	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_1689375_1	866775.HMPREF9243_0245	7.2e-06	52.8	COG1011@1|root,COG1011@2|Bacteria,1V3WC@1239|Firmicutes,4HHZ7@91061|Bacilli	91061|Bacilli	S	hydrolase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
k59_1744496_2	867903.ThesuDRAFT_00562	9.9e-78	239.0	COG0090@1|root,COG0090@2|Bacteria,1TP9X@1239|Firmicutes,247XY@186801|Clostridia,3WCDD@538999|Clostridiales incertae sedis	186801|Clostridia	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
k59_1356022_1	1347342.BN863_10240	7.5e-69	226.0	COG3119@1|root,COG3119@2|Bacteria,4NHH7@976|Bacteroidetes,1HX4R@117743|Flavobacteriia	976|Bacteroidetes	P	arylsulfatase a	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
k59_243788_1	1502852.FG94_04481	2.76e-22	101.0	COG2374@1|root,COG2374@2|Bacteria,1MX52@1224|Proteobacteria,2VK7U@28216|Betaproteobacteria,476KP@75682|Oxalobacteraceae	28216|Betaproteobacteria	O	Lamin Tail Domain	-	-	-	ko:K07004	-	-	-	-	ko00000	-	-	-	Exo_endo_phos,LTD
k59_521954_1	926550.CLDAP_16790	3.97e-50	166.0	COG2129@1|root,COG2129@2|Bacteria,2G8MC@200795|Chloroflexi	200795|Chloroflexi	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
k59_1356030_1	1124983.PFLCHA0_c45330	5.63e-46	164.0	COG1807@1|root,COG1807@2|Bacteria,1QR8D@1224|Proteobacteria,1RU4H@1236|Gammaproteobacteria,1YNZ7@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
k59_243795_1	1111134.HMPREF1253_0261	1.95e-30	119.0	COG0126@1|root,COG0126@2|Bacteria,1TP3H@1239|Firmicutes,248VS@186801|Clostridia,22GEA@1570339|Peptoniphilaceae	186801|Clostridia	F	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3,5.3.1.1	ko:K00927,ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01015,R01512	RC00002,RC00043,RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
k59_243795_2	926569.ANT_13250	1.7e-19	86.7	COG0057@1|root,COG0057@2|Bacteria,2G5MG@200795|Chloroflexi	200795|Chloroflexi	C	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gap	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
k59_1580371_1	596153.Alide_4621	2.85e-93	289.0	COG4584@1|root,COG4584@2|Bacteria,1MU2G@1224|Proteobacteria,2VJIW@28216|Betaproteobacteria,4AB7Y@80864|Comamonadaceae	28216|Betaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_524095_1	932678.THERU_01595	1.36e-11	64.7	2E20Q@1|root,32X8P@2|Bacteria,2G53C@200783|Aquificae	200783|Aquificae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_412880_1	671143.DAMO_2940	3.83e-29	106.0	COG0718@1|root,COG0718@2|Bacteria,2NPUK@2323|unclassified Bacteria	2|Bacteria	S	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection	ybaB	-	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
k59_412880_2	401526.TcarDRAFT_2542	0.000956	45.1	COG2812@1|root,COG2812@2|Bacteria,1TPS9@1239|Firmicutes,4H359@909932|Negativicutes	909932|Negativicutes	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
k59_1524683_1	153948.NAL212_1340	3.98e-47	172.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,2VM4W@28216|Betaproteobacteria,372UR@32003|Nitrosomonadales	28216|Betaproteobacteria	G	PFAM glycosyl transferase, family 35	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
k59_914598_1	644282.Deba_1638	1e-29	124.0	COG0531@1|root,COG0531@2|Bacteria,1MXNJ@1224|Proteobacteria,42MGQ@68525|delta/epsilon subdivisions,2WJ87@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	COGs COG0531 Amino acid transporter	-	-	-	ko:K03294,ko:K20265	ko02024,map02024	-	-	-	ko00000,ko00001,ko02000	2.A.3.2,2.A.3.7.1,2.A.3.7.3	-	-	AA_permease_2
k59_1079834_1	1296416.JACB01000029_gene4189	3.03e-50	169.0	COG4916@1|root,COG4916@2|Bacteria,4NRKR@976|Bacteroidetes,1I4HF@117743|Flavobacteriia,2YHBK@290174|Aquimarina	976|Bacteroidetes	S	TIR domain	-	-	-	-	-	-	-	-	-	-	-	-	TIR_2
k59_1079841_2	1340493.JNIF01000003_gene1919	8.23e-68	232.0	COG5000@1|root,COG5000@2|Bacteria,3Y32Z@57723|Acidobacteria	57723|Acidobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
k59_969415_1	414684.RC1_2667	1.86e-140	424.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2TTBF@28211|Alphaproteobacteria,2JR68@204441|Rhodospirillales	204441|Rhodospirillales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_1079844_1	1051632.TPY_2012	1.99e-35	137.0	COG1529@1|root,COG2080@1|root,COG1529@2|Bacteria,COG2080@2|Bacteria,1TP7U@1239|Firmicutes,248BV@186801|Clostridia,3WD5H@538999|Clostridiales incertae sedis	186801|Clostridia	C	Aldehyde oxidase and xanthine dehydrogenase, a b hammerhead domain	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2
k59_412911_1	545264.KB898745_gene1088	2.49e-89	273.0	COG3588@1|root,COG3588@2|Bacteria,1MVFK@1224|Proteobacteria,1RQ57@1236|Gammaproteobacteria,1WZYG@135613|Chromatiales	135613|Chromatiales	G	Fructose-bisphosphate aldolase class-I	-	-	4.1.2.13	ko:K01623	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000,ko03036,ko04131,ko04147	-	-	-	Glycolytic
k59_412917_1	1499967.BAYZ01000104_gene3692	4.09e-40	147.0	COG0738@1|root,COG0738@2|Bacteria	2|Bacteria	G	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1248599_1	518766.Rmar_1775	2.12e-34	134.0	COG0457@1|root,COG0457@2|Bacteria,4NFIY@976|Bacteroidetes	976|Bacteroidetes	S	Peptidase, family M49	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M49
k59_1191337_1	1121413.JMKT01000011_gene2230	6.93e-47	169.0	COG2208@1|root,COG2770@1|root,COG2208@2|Bacteria,COG2770@2|Bacteria,1MXJQ@1224|Proteobacteria,42MFQ@68525|delta/epsilon subdivisions,2WIJ4@28221|Deltaproteobacteria,2M7Z5@213115|Desulfovibrionales	28221|Deltaproteobacteria	KT	SMART protein phosphatase 2C domain protein	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	Cache_3-Cache_2,HAMP,SpoIIE,dCache_1,dCache_2
k59_190189_1	1197906.CAJQ02000024_gene1323	2.2e-82	249.0	COG0447@1|root,COG0447@2|Bacteria,1QTZ2@1224|Proteobacteria,2U0ZZ@28211|Alphaproteobacteria,3JWVZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	H	Belongs to the enoyl-CoA hydratase isomerase family. MenB subfamily	menB	-	4.1.3.36	ko:K01661,ko:K07536	ko00130,ko00362,ko01100,ko01110,ko01120,ko01220,map00130,map00362,map01100,map01110,map01120,map01220	M00116,M00540	R05592,R07263	RC01429,RC01923	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
k59_1469501_1	1538644.KO02_00705	1.35e-19	94.7	COG2120@1|root,COG2120@2|Bacteria,4NE9K@976|Bacteroidetes,1IPTV@117747|Sphingobacteriia	976|Bacteroidetes	G	LmbE family	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
k59_79114_1	1278073.MYSTI_03023	8.49e-41	152.0	COG2234@1|root,COG2234@2|Bacteria,1MV86@1224|Proteobacteria,43E81@68525|delta/epsilon subdivisions,2WZZ4@28221|Deltaproteobacteria,2YU4S@29|Myxococcales	28221|Deltaproteobacteria	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
k59_1580451_1	396588.Tgr7_0692	5.35e-143	415.0	COG2801@1|root,COG2801@2|Bacteria,1N207@1224|Proteobacteria,1S1FB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_28,HTH_32,LZ_Tnp_IS481,rve,rve_3
k59_691377_1	926569.ANT_13870	2.64e-57	192.0	COG4962@1|root,COG4962@2|Bacteria,2G7K7@200795|Chloroflexi	200795|Chloroflexi	U	PFAM type II secretion system protein E	-	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
k59_301863_1	926569.ANT_16290	4.98e-72	235.0	COG2759@1|root,COG2759@2|Bacteria,2G5QS@200795|Chloroflexi	200795|Chloroflexi	F	Belongs to the formate--tetrahydrofolate ligase family	fhs	GO:0003674,GO:0003824,GO:0004329,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006144,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009112,GO:0009113,GO:0009256,GO:0009257,GO:0009396,GO:0009987,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0016874,GO:0016879,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042440,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.5.1.5,3.5.4.9,6.3.4.3	ko:K00288,ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00141,M00377	R00943,R01220,R01655	RC00026,RC00111,RC00202,RC00578	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	FTHFS
k59_190208_1	1349822.NSB1T_08720	7.65e-10	64.7	COG3537@1|root,COG3537@2|Bacteria,4NDYB@976|Bacteroidetes,2FMQ9@200643|Bacteroidia,22W3K@171551|Porphyromonadaceae	976|Bacteroidetes	G	Glycosyl hydrolase family 92	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_92
k59_412971_1	234267.Acid_2183	4.16e-24	105.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_1136217_1	926569.ANT_10570	1.92e-115	355.0	COG1185@1|root,COG1185@2|Bacteria,2G5TS@200795|Chloroflexi	200795|Chloroflexi	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004654,GO:0005488,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
k59_969469_1	1121930.AQXG01000005_gene719	8.9e-16	78.6	COG1510@1|root,COG1510@2|Bacteria,4NQPD@976|Bacteroidetes,1ISGU@117747|Sphingobacteriia	976|Bacteroidetes	K	Belongs to the GbsR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5,MarR_2,TrmB
k59_802265_1	314278.NB231_16478	5.64e-80	256.0	COG0366@1|root,COG0366@2|Bacteria,1MWBZ@1224|Proteobacteria,1RYKS@1236|Gammaproteobacteria,1WX35@135613|Chromatiales	135613|Chromatiales	G	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB	glgE	-	2.4.99.16	ko:K16147	ko00500,ko01100,map00500,map01100	-	R09994	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3416
k59_1136221_1	1234595.C725_1308	5.61e-52	180.0	COG1012@1|root,COG1012@2|Bacteria,1MVGW@1224|Proteobacteria,2TR9T@28211|Alphaproteobacteria,4BPSC@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Aldehyde dehydrogenase family	calB	-	1.2.1.68,1.2.99.10	ko:K00154,ko:K22445	-	-	-	-	ko00000,ko01000	-	-	-	Aldedh
k59_356869_1	1048834.TC41_2669	8.75e-09	60.8	COG4454@1|root,COG4454@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	SoxE
k59_1634865_1	247634.GPB2148_14	1.06e-28	112.0	COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,1PBHA@1224|Proteobacteria	1224|Proteobacteria	L	Transposase and inactivated derivatives	-	-	2.7.7.49	ko:K00986,ko:K07497	-	-	-	-	ko00000,ko01000	-	-	-	HTH_32,rve,rve_3
k59_1191376_1	59538.XP_005961496.1	2.32e-61	202.0	COG0152@1|root,KOG2835@2759|Eukaryota,38CMB@33154|Opisthokonta,3BXK6@33208|Metazoa,3DDV4@33213|Bilateria	33208|Metazoa	F	AIR carboxylase	-	-	4.1.1.21,6.3.2.6	ko:K01587	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04209,R04591	RC00064,RC00162,RC00590	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
k59_1248643_1	477641.MODMU_4480	1.09e-62	211.0	COG0028@1|root,COG0028@2|Bacteria,2GKU4@201174|Actinobacteria,4ES0H@85013|Frankiales	201174|Actinobacteria	E	TIGRFAM Acetolactate synthase, large subunit, biosynthetic	ilvB	GO:0000287,GO:0003674,GO:0003824,GO:0003984,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0019842,GO:0030312,GO:0030976,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046872,GO:0048037,GO:0050662,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901681	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv3003c	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_1524782_1	388413.ALPR1_13520	3.2e-65	224.0	COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,4NFHX@976|Bacteroidetes,47KS7@768503|Cytophagia	976|Bacteroidetes	EI	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly	icmF	-	5.4.99.13	ko:K11942	-	-	-	-	ko00000,ko01000	-	-	-	ArgK,B12-binding,MM_CoA_mutase
k59_79152_1	635013.TherJR_2514	1.43e-12	65.1	COG0724@1|root,COG0724@2|Bacteria,1VBMH@1239|Firmicutes,24NVR@186801|Clostridia,262F2@186807|Peptococcaceae	186801|Clostridia	S	PFAM RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
k59_1302689_1	311402.Avi_7426	2.03e-09	61.2	COG2079@1|root,COG2079@2|Bacteria,1PMKJ@1224|Proteobacteria,2V07A@28211|Alphaproteobacteria,4BDIS@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	MmgE/PrpD family	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
k59_1524790_1	1035308.AQYY01000001_gene1676	6e-56	186.0	COG4449@1|root,COG4449@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_634304_1	671143.DAMO_0587	2.24e-102	310.0	COG0460@1|root,COG0460@2|Bacteria,2NP8S@2323|unclassified Bacteria	2|Bacteria	E	homoserine dehydrogenase	hom	GO:0003674,GO:0003824,GO:0004412,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0030312,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1294,iSB619.SA_RS06610	ACT,Homoserine_dh,NAD_binding_3
k59_1191394_1	1183438.GKIL_4242	2.02e-102	306.0	COG1830@1|root,COG1830@2|Bacteria,1G3Z5@1117|Cyanobacteria	1117|Cyanobacteria	G	DeoC/LacD family aldolase	-	-	4.1.2.13	ko:K11645	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
k59_469728_1	1168289.AJKI01000042_gene3707	7.9e-190	542.0	COG3534@1|root,COG3534@2|Bacteria,4NHR5@976|Bacteroidetes,2G2XU@200643|Bacteroidia,3XKKF@558415|Marinilabiliaceae	976|Bacteroidetes	G	Alpha-L-arabinofuranosidase C-terminal domain	-	-	3.2.1.55	ko:K01209	ko00520,map00520	-	R01762	-	ko00000,ko00001,ko01000	-	GH51	-	Alpha-L-AF_C
k59_1248664_1	411684.HPDFL43_21102	8.47e-08	53.1	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2TSMP@28211|Alphaproteobacteria,43P1X@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
k59_1248664_2	172088.AUGA01000002_gene5947	6.47e-16	80.1	COG0559@1|root,COG0559@2|Bacteria,1N5XH@1224|Proteobacteria,2TSH5@28211|Alphaproteobacteria,3JS3Y@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_746711_1	1267535.KB906767_gene5449	3.08e-23	103.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_1025571_1	861299.J421_2028	1.42e-30	124.0	COG0577@1|root,COG0577@2|Bacteria	861299.J421_2028|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1428210_1	1122137.AQXF01000003_gene1948	1.97e-66	224.0	COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,2TRI9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	exporters of the RND superfamily	MA20_16090	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
k59_1760142_2	1329516.JPST01000006_gene1599	1.91e-27	112.0	COG4603@1|root,COG4603@2|Bacteria,1TP1F@1239|Firmicutes,4H9VE@91061|Bacilli,27AU6@186824|Thermoactinomycetaceae	91061|Bacilli	S	Branched-chain amino acid transport system / permease component	yufP	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0015144,GO:0015145,GO:0015749,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0034219,GO:0044425,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
k59_1041544_2	526227.Mesil_3298	9.86e-54	181.0	COG0174@1|root,COG0174@2|Bacteria,1WM8G@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Glutamine synthetase, catalytic domain	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
k59_1095224_1	589924.Ferp_0322	3.08e-30	121.0	COG0439@1|root,arCOG01590@2157|Archaea,2Y8CM@28890|Euryarchaeota,245X6@183980|Archaeoglobi	183980|Archaeoglobi	I	acetyl-CoA carboxylase, biotin carboxylase	-	-	6.4.1.1	ko:K01959	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
k59_1205750_1	98439.AJLL01000060_gene982	2.88e-33	123.0	COG0745@1|root,COG0745@2|Bacteria,1G0YA@1117|Cyanobacteria,1JH4C@1189|Stigonemataceae	1117|Cyanobacteria	T	Transcriptional regulatory protein, C terminal	rpaB	-	-	ko:K11329	ko02020,map02020	M00467	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_1708141_2	1379270.AUXF01000002_gene1266	2.41e-36	132.0	COG3170@1|root,COG3170@2|Bacteria,1ZUU4@142182|Gemmatimonadetes	142182|Gemmatimonadetes	NU	Protein of unknown function (DUF3108)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3108
k59_1095232_1	861299.J421_3771	1.65e-182	533.0	COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1ZT01@142182|Gemmatimonadetes	2|Bacteria	C	Phosphate acetyl/butaryl transferase	maeB	GO:0003674,GO:0003824,GO:0004470,GO:0004473,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0030145,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0055114	1.1.1.38,1.1.1.40,2.3.1.8	ko:K00027,ko:K00029,ko:K00625,ko:K13788	ko00430,ko00620,ko00640,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,ko02020,map00430,map00620,map00640,map00680,map00710,map00720,map01100,map01120,map01200,map02020	M00169,M00172,M00357,M00579	R00214,R00216,R00230,R00921	RC00004,RC00105,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1637	Malic_M,PTA_PTB,malic
k59_985249_1	1192759.AKIB01000006_gene65	2.96e-37	135.0	COG1028@1|root,COG1028@2|Bacteria,1R6C1@1224|Proteobacteria,2V7S9@28211|Alphaproteobacteria,2K960@204457|Sphingomonadales	204457|Sphingomonadales	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_930803_1	671143.DAMO_2605	2.29e-26	112.0	COG1033@1|root,COG1033@2|Bacteria,2NQ2I@2323|unclassified Bacteria	2|Bacteria	S	MMPL family	hpnN	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
k59_1484692_1	251221.35211937	1.01e-138	404.0	COG0520@1|root,COG0520@2|Bacteria,1G15D@1117|Cyanobacteria	1117|Cyanobacteria	E	Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family	-	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
k59_427427_1	926569.ANT_03290	4.18e-155	451.0	COG0119@1|root,COG0119@2|Bacteria,2G5V9@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
k59_1648768_1	316067.Geob_0347	6.61e-25	107.0	COG0729@1|root,COG0729@2|Bacteria,1MUKM@1224|Proteobacteria,42MB2@68525|delta/epsilon subdivisions,2WJAF@28221|Deltaproteobacteria,43U8C@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	POTRA domain TamA domain 1	-	-	-	ko:K07277,ko:K07278	-	-	-	-	ko00000,ko02000,ko03029	1.B.33,1.B.33.2.4	-	-	Bac_surface_Ag,POTRA,POTRA_TamA_1
k59_1484705_1	948106.AWZT01000017_gene80	1.67e-114	350.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2VI9R@28216|Betaproteobacteria,1K035@119060|Burkholderiaceae	28216|Betaproteobacteria	C	CoA-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,Acetyltransf_3,Acetyltransf_4,CoA_binding_2,Succ_CoA_lig
k59_371821_1	1184267.A11Q_222	0.000684	40.8	COG3311@1|root,COG3311@2|Bacteria,1N779@1224|Proteobacteria,42VDM@68525|delta/epsilon subdivisions,2WR6J@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	TIGRFAM DNA binding domain protein, excisionase family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17
k59_1595749_1	991905.SL003B_1319	3.88e-121	379.0	COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria,4BPWR@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	EQ	Hydantoinase B/oxoprolinase	oplA	-	3.5.2.9	ko:K01469	ko00480,map00480	-	R00251	RC00553	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A,Hydantoinase_B
k59_148704_1	1437425.CSEC_0410	3.85e-32	127.0	COG0513@1|root,COG0513@2|Bacteria,2JFPJ@204428|Chlamydiae	204428|Chlamydiae	L	Belongs to the DEAD box helicase family	-	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,Helicase_C
k59_1648792_1	1459636.NTE_02785	1.53e-60	199.0	COG0477@1|root,arCOG00132@2157|Archaea	2157|Archaea	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
k59_648165_1	936573.HMPREF1147_0555	6.14e-34	129.0	COG0452@1|root,COG0452@2|Bacteria,1TPP3@1239|Firmicutes,4H27H@909932|Negativicutes	909932|Negativicutes	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
k59_648165_2	768670.Calni_1669	3.81e-19	85.5	2CA4A@1|root,32RQK@2|Bacteria,2GFRZ@200930|Deferribacteres	200930|Deferribacteres	S	Domain of unknown function (DUF4416)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4416
k59_203799_2	1089548.KI783301_gene1388	8.24e-20	91.7	COG1208@1|root,COG1208@2|Bacteria,1VDBC@1239|Firmicutes,4IS8X@91061|Bacilli,3WG72@539002|Bacillales incertae sedis	91061|Bacilli	JM	MobA-like NTP transferase domain	-	-	2.7.7.13	ko:K00966	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
k59_1095283_1	1382306.JNIM01000001_gene661	2.8e-49	167.0	COG0842@1|root,COG0842@2|Bacteria,2G6H9@200795|Chloroflexi	2|Bacteria	V	Transport permease protein	pedC	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
k59_593809_1	1162668.LFE_2477	1.11e-25	103.0	COG1183@1|root,COG1183@2|Bacteria,3J0KW@40117|Nitrospirae	40117|Nitrospirae	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_transf
k59_593809_2	1267534.KB906754_gene2997	3.78e-18	82.8	COG0688@1|root,COG0688@2|Bacteria,3Y4AZ@57723|Acidobacteria,2JJ6I@204432|Acidobacteriia	204432|Acidobacteriia	I	Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)	psd	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
k59_1595780_1	316067.Geob_0122	1.15e-06	55.8	COG2010@1|root,COG2010@2|Bacteria,1RJJ2@1224|Proteobacteria,42SCM@68525|delta/epsilon subdivisions,2WPS4@28221|Deltaproteobacteria,43U4I@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Cytochrome c	pcmF	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
k59_1318784_1	324925.Ppha_2442	1.85e-10	65.1	COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1FEF9@1090|Chlorobi	1090|Chlorobi	C	electron transfer flavoprotein-ubiquinone oxidoreductase	-	-	1.5.5.1	ko:K00311	-	-	-	-	ko00000,ko01000	-	-	-	ETF_QO
k59_648175_1	96561.Dole_0563	6.53e-38	132.0	2A4CF@1|root,30SY3@2|Bacteria,1RFXP@1224|Proteobacteria,42RIM@68525|delta/epsilon subdivisions,2WNS6@28221|Deltaproteobacteria,2MNMZ@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Yip1
k59_427476_1	118173.KB235914_gene4304	6.8e-26	103.0	2AQ5P@1|root,31FB4@2|Bacteria,1G7CB@1117|Cyanobacteria,1HG1V@1150|Oscillatoriales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_150550_1	315750.BPUM_0979	1.63e-17	83.6	COG3616@1|root,COG3616@2|Bacteria,1TSES@1239|Firmicutes,4HDIP@91061|Bacilli,1ZEFH@1386|Bacillus	91061|Bacilli	E	Putative serine dehydratase domain	-	-	-	-	-	-	-	-	-	-	-	-	Ala_racemase_N,D-ser_dehydrat
k59_150550_2	483219.LILAB_14380	2.28e-21	94.4	COG4784@1|root,COG4784@2|Bacteria,1QTT7@1224|Proteobacteria,43C89@68525|delta/epsilon subdivisions,2X7IN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
k59_1097020_1	1304865.JAGF01000001_gene686	3.29e-49	178.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2GK73@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_1043239_1	926550.CLDAP_05920	8.97e-31	121.0	COG1894@1|root,COG1905@1|root,COG1894@2|Bacteria,COG1905@2|Bacteria,2G5W1@200795|Chloroflexi	200795|Chloroflexi	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	-	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
k59_1320389_1	289376.THEYE_A1890	4.76e-69	236.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,3J0XC@40117|Nitrospirae	40117|Nitrospirae	T	Adenylate cyclase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
k59_873418_1	247633.GP2143_17796	6.68e-49	169.0	28NHI@1|root,2ZBJA@2|Bacteria,1RCPZ@1224|Proteobacteria,1ST6N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1429984_1	504728.K649_01260	0.000197	48.9	COG0624@1|root,COG0624@2|Bacteria,1WIA9@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	PFAM Peptidase family M20 M25 M40	-	-	3.4.17.11	ko:K01295	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
k59_932639_1	631362.Thi970DRAFT_00233	1.75e-42	160.0	COG3464@1|root,COG3464@2|Bacteria,1N5CJ@1224|Proteobacteria,1T4WB@1236|Gammaproteobacteria,1WZSX@135613|Chromatiales	1236|Gammaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1540258_1	926569.ANT_22700	6.5e-141	417.0	COG1132@1|root,COG1132@2|Bacteria,2G7KA@200795|Chloroflexi	200795|Chloroflexi	P	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_39292_1	1267211.KI669560_gene2369	3.61e-108	324.0	COG0334@1|root,COG0334@2|Bacteria,4NEBH@976|Bacteroidetes,1IPRA@117747|Sphingobacteriia	976|Bacteroidetes	E	Belongs to the Glu Leu Phe Val dehydrogenases family	gdhA	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
k59_1043251_1	926569.ANT_30270	2.11e-71	235.0	COG0673@1|root,COG1063@1|root,COG0673@2|Bacteria,COG1063@2|Bacteria,2G75J@200795|Chloroflexi	200795|Chloroflexi	C	PFAM Alcohol dehydrogenase zinc-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
k59_1097043_1	485913.Krac_9626	2.73e-61	197.0	COG3039@1|root,COG3039@2|Bacteria,2G8AJ@200795|Chloroflexi	200795|Chloroflexi	L	SPTR B2JC10 Transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_319464_1	1173028.ANKO01000197_gene6110	1.14e-32	132.0	COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1G0GI@1117|Cyanobacteria,1H9N1@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GAF_3,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
k59_873431_1	160860.XP_007339753.1	2.1e-19	89.0	28IP3@1|root,2QR03@2759|Eukaryota,396BN@33154|Opisthokonta,3NXB9@4751|Fungi,3V4ZJ@5204|Basidiomycota,2255J@155619|Agaricomycetes,3H315@355688|Agaricomycetes incertae sedis	4751|Fungi	O	Glycoside Hydrolase family 74	-	-	3.2.1.155	ko:K18578	-	-	-	-	ko00000,ko01000	-	CBM1,GH74	-	CBM_1
k59_873431_2	1121373.KB903647_gene3339	1.17e-19	89.0	COG2730@1|root,COG4447@1|root,COG5276@1|root,COG2730@2|Bacteria,COG4447@2|Bacteria,COG5276@2|Bacteria,4NK79@976|Bacteroidetes,47U3E@768503|Cytophagia	976|Bacteroidetes	G	TIGRFAM Por secretion system C-terminal sorting domain	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1207466_1	886293.Sinac_2843	4.22e-08	60.1	COG1680@1|root,COG2173@1|root,COG1680@2|Bacteria,COG2173@2|Bacteria,2IWSU@203682|Planctomycetes	203682|Planctomycetes	MV	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,Peptidase_M15
k59_1265783_1	747365.Thena_0747	7.17e-06	52.8	COG0617@1|root,COG0617@2|Bacteria,1TQ2A@1239|Firmicutes,247XC@186801|Clostridia,42FBY@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM Polynucleotide adenylyltransferase region	-	-	2.7.7.19,2.7.7.72	ko:K00970,ko:K00974	ko03013,ko03018,map03013,map03018	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2
k59_1043263_1	573.JG24_00995	3.24e-88	274.0	COG2801@1|root,COG2801@2|Bacteria,1MWVQ@1224|Proteobacteria,1RN12@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_28,HTH_32,rve
k59_1265785_1	315730.BcerKBAB4_5168	8.75e-19	90.5	COG0744@1|root,COG0744@2|Bacteria,1TPM5@1239|Firmicutes,4H9SA@91061|Bacilli,1ZBUK@1386|Bacillus	91061|Bacilli	M	penicillin-binding protein	pbpG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.4.1.129,3.4.16.4	ko:K21464	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
k59_873439_1	1123508.JH636439_gene1010	5.28e-70	226.0	COG0031@1|root,COG0031@2|Bacteria,2IY6T@203682|Planctomycetes	203682|Planctomycetes	E	Pyridoxal-phosphate dependent enzyme	-	-	4.2.1.22	ko:K01697	ko00260,ko00270,ko01100,ko01130,ko01230,map00260,map00270,map01100,map01130,map01230	M00035,M00338	R00891,R01290,R04942	RC00056,RC00069,RC00256,RC00489,RC01246	ko00000,ko00001,ko00002,ko01000	-	-	-	CBS,PALP
k59_595540_1	1123258.AQXZ01000016_gene2524	1.66e-12	73.2	COG0470@1|root,COG2319@1|root,COG0470@2|Bacteria,COG2319@2|Bacteria,2GJN3@201174|Actinobacteria,4FUSK@85025|Nocardiaceae	201174|Actinobacteria	L	WD40 repeats	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31,WD40
k59_1207480_1	530564.Psta_3183	4.53e-50	168.0	COG1321@1|root,COG1321@2|Bacteria,2IYW3@203682|Planctomycetes	203682|Planctomycetes	K	iron dependent repressor	-	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA
k59_39318_1	1229780.BN381_80228	2.39e-79	248.0	COG1960@1|root,COG1960@2|Bacteria,2GIX8@201174|Actinobacteria,3UX43@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_261389_1	926569.ANT_17960	3.07e-26	107.0	COG0719@1|root,COG0719@2|Bacteria,2G5S8@200795|Chloroflexi	200795|Chloroflexi	O	TIGRFAM FeS assembly protein SufD	sufD	-	-	ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
k59_261389_2	1121372.AULK01000001_gene1980	1.37e-16	76.3	COG2146@1|root,COG2146@2|Bacteria,2IQK7@201174|Actinobacteria,4FP2S@85023|Microbacteriaceae	201174|Actinobacteria	P	Rieske-like [2Fe-2S] domain	hcaC	-	-	ko:K05710	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002	-	-	-	Rieske
k59_261389_3	1136177.KCA1_1248	3.13e-06	50.1	COG0520@1|root,COG0520@2|Bacteria,1TQ1W@1239|Firmicutes,4HA6Z@91061|Bacilli,3F3UP@33958|Lactobacillaceae	91061|Bacilli	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	sufS	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
k59_95714_1	1459636.NTE_00733	3.7e-49	164.0	COG0189@1|root,arCOG01589@2157|Archaea,41SCQ@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Lysine biosynthesis	-	-	6.3.2.43	ko:K05827	ko00300,ko01100,ko01210,ko01230,map00300,map01100,map01210,map01230	M00031	R09775	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	RimK
k59_95723_1	483219.LILAB_08885	2.6e-62	214.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,42NYP@68525|delta/epsilon subdivisions,2WIPJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Belongs to the peptidase M16 family	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_1320444_1	1382304.JNIL01000001_gene1396	4.72e-17	80.1	COG1804@1|root,COG1804@2|Bacteria,1TP54@1239|Firmicutes,4HABI@91061|Bacilli	91061|Bacilli	C	acyl-CoA transferases carnitine dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_1320444_2	398580.Dshi_1048	2.19e-23	99.4	COG1024@1|root,COG1024@2|Bacteria,1MXBB@1224|Proteobacteria,2TU4V@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.1.1.41,4.2.1.17	ko:K01692,ko:K11264	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R00923,R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00097,RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
k59_205462_1	643473.KB235930_gene1962	7.56e-75	253.0	COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria,1HKNU@1161|Nostocales	1117|Cyanobacteria	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,Methyltransf_12,PP-binding,Thioesterase
k59_1375230_1	1519464.HY22_07105	1.13e-25	110.0	COG1506@1|root,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9
k59_429162_1	795359.TOPB45_0362	4.38e-31	122.0	COG0644@1|root,COG0644@2|Bacteria	2|Bacteria	C	geranylgeranyl reductase activity	-	-	1.3.1.101,1.3.7.11,5.5.1.18	ko:K06444,ko:K17830	ko00564,ko00906,ko01100,ko01110,map00564,map00906,map01100,map01110	-	R06960,R06963,R07840,R10325,R10326,R10331	RC01612,RC03134	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3,Lycopene_cycl,NAD_binding_8,Pyr_redox_2,Trp_halogenase
k59_762613_1	882083.SacmaDRAFT_2540	2.61e-30	123.0	COG1178@1|root,COG1178@2|Bacteria,2GKDH@201174|Actinobacteria,4EAXP@85010|Pseudonocardiales	201174|Actinobacteria	P	ABC-type Fe3 transport system, permease component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1,SBP_bac_6
k59_595595_1	861299.J421_2893	4.07e-23	101.0	2F044@1|root,33T7T@2|Bacteria	861299.J421_2893|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_873492_1	554065.XP_005845781.1	7.21e-21	88.6	COG0607@1|root,KOG1530@2759|Eukaryota,37UIG@33090|Viridiplantae,34IXX@3041|Chlorophyta	3041|Chlorophyta	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_873492_2	671143.DAMO_0883	1.46e-36	130.0	COG0491@1|root,COG0491@2|Bacteria,2NPD5@2323|unclassified Bacteria	2|Bacteria	S	Metallo-beta-lactamase superfamily	pksB	GO:0003674,GO:0003824,GO:0004416,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006082,GO:0006090,GO:0006518,GO:0006575,GO:0006749,GO:0006750,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016787,GO:0016788,GO:0016790,GO:0019184,GO:0019752,GO:0031974,GO:0032787,GO:0034641,GO:0042398,GO:0043043,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0051186,GO:0051188,GO:0070013,GO:0071704,GO:1901564,GO:1901566,GO:1901576	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
k59_818522_1	1123257.AUFV01000002_gene2367	3.85e-17	81.3	COG3752@1|root,COG3752@2|Bacteria,1RD8F@1224|Proteobacteria,1S3R5@1236|Gammaproteobacteria,1XA2S@135614|Xanthomonadales	135614|Xanthomonadales	S	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1295
k59_818522_2	523791.Kkor_2389	1.52e-08	57.4	COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,1RNC8@1236|Gammaproteobacteria,1XP2X@135619|Oceanospirillales	135619|Oceanospirillales	S	OPT oligopeptide transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	OPT
k59_1375271_1	557598.LHK_00846	1.19e-62	198.0	COG1402@1|root,COG1402@2|Bacteria,1MXR9@1224|Proteobacteria	1224|Proteobacteria	F	Creatininase	crnA_1	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
k59_1761947_1	1385420.FRA_44c11290	3.82e-11	63.2	COG1949@1|root,COG1949@2|Bacteria,1R9WX@1224|Proteobacteria,1S217@1236|Gammaproteobacteria,460FA@72273|Thiotrichales	72273|Thiotrichales	L	3'-to-5' exoribonuclease specific for small oligoribonucleotides	orn	-	-	ko:K13288	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	RNase_T
k59_487006_1	926562.Oweho_2200	6.04e-49	182.0	COG0841@1|root,COG0841@2|Bacteria,4NDZG@976|Bacteroidetes,1HX2H@117743|Flavobacteriia,2PBB4@246874|Cryomorphaceae	976|Bacteroidetes	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_39399_2	948106.AWZT01000003_gene5779	2.01e-28	107.0	COG0346@1|root,COG0346@2|Bacteria,1RHD4@1224|Proteobacteria,2VSJM@28216|Betaproteobacteria,1K7MX@119060|Burkholderiaceae	28216|Betaproteobacteria	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K08234	-	-	-	-	ko00000	-	-	-	Glyoxalase
k59_95789_1	8010.XP_010898171.1	4.47e-19	92.4	COG0462@1|root,KOG0225@2759|Eukaryota,38G37@33154|Opisthokonta,3BBAB@33208|Metazoa,3CUBV@33213|Bilateria,488JJ@7711|Chordata,493T6@7742|Vertebrata,49Q0M@7898|Actinopterygii	33208|Metazoa	C	Pyruvate dehydrogenase E1 component subunit alpha	PDHA1	GO:0003674,GO:0003824,GO:0004738,GO:0004739,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005730,GO:0005737,GO:0005739,GO:0005759,GO:0005967,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006091,GO:0006099,GO:0006101,GO:0006139,GO:0006163,GO:0006164,GO:0006637,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009060,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015980,GO:0016491,GO:0016620,GO:0016624,GO:0016903,GO:0016999,GO:0017144,GO:0018130,GO:0019362,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0031974,GO:0031981,GO:0032787,GO:0032991,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034603,GO:0034604,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0043209,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045254,GO:0045333,GO:0046390,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0061732,GO:0070013,GO:0071616,GO:0071704,GO:0072350,GO:0072521,GO:0072522,GO:0072524,GO:0090407,GO:0098798,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902494,GO:1990204	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
k59_1540362_2	1243664.CAVL020000045_gene2105	9.03e-86	268.0	COG0439@1|root,COG0439@2|Bacteria,1TP16@1239|Firmicutes,4HA40@91061|Bacilli,1ZMF3@1386|Bacillus	91061|Bacilli	I	Biotin carboxylase C-terminal domain	-	-	6.3.4.6	ko:K01941	ko00220,ko00791,ko01100,map00220,map00791,map01100	-	R00774	RC00378	ko00000,ko00001,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,CT_A_B,CT_C_D
k59_873519_1	1108045.GORHZ_154_00260	2e-109	327.0	COG2072@1|root,COG2072@2|Bacteria,2GM3S@201174|Actinobacteria,4GGGG@85026|Gordoniaceae	201174|Actinobacteria	P	Flavin-binding monooxygenase-like	-	-	-	ko:K07222	-	-	-	-	ko00000	-	-	-	Pyr_redox_3
k59_1597587_1	1147.D082_23340	0.000129	44.3	COG1595@1|root,COG1595@2|Bacteria,1G5PA@1117|Cyanobacteria,1H6CR@1142|Synechocystis	1117|Cyanobacteria	K	ECF sigma factor	sigH	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
k59_762656_1	266940.Krad_1151	1.4e-26	104.0	COG1595@1|root,COG1595@2|Bacteria,2GK4C@201174|Actinobacteria	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	sigE	GO:0000302,GO:0000988,GO:0000990,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009405,GO:0009408,GO:0009410,GO:0009605,GO:0009607,GO:0009628,GO:0009636,GO:0009889,GO:0010035,GO:0010468,GO:0010556,GO:0016987,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0040007,GO:0042221,GO:0042493,GO:0042542,GO:0043207,GO:0043254,GO:0044087,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0060255,GO:0065007,GO:0075136,GO:0080090,GO:0090034,GO:0097159,GO:0140110,GO:1901363,GO:1901700,GO:1903506,GO:2000112,GO:2000142,GO:2001141	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_334216_1	1379270.AUXF01000001_gene2325	1.66e-107	350.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1ZSQA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Conserved region in glutamate synthase	-	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_1223796_1	1123279.ATUS01000001_gene960	1.59e-39	149.0	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,1RPAV@1236|Gammaproteobacteria,1J4U2@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003909,GO:0003911,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0034645,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050662,GO:0050896,GO:0051103,GO:0051287,GO:0051716,GO:0070403,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1901576	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	iEC55989_1330.EC55989_2701,iECABU_c1320.ECABU_c27320,iECIAI1_1343.ECIAI1_2469,iECO103_1326.ECO103_2930,iECO111_1330.ECO111_3141,iECO26_1355.ECO26_3464,iECSE_1348.ECSE_2702,iECW_1372.ECW_m2640,iEKO11_1354.EKO11_1317,iEcE24377_1341.EcE24377A_2698,iEcSMS35_1347.EcSMS35_2566,iWFL_1372.ECW_m2640,iYL1228.KPN_02758,ic_1306.c2945	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
k59_1612893_1	926550.CLDAP_11050	3.29e-34	129.0	COG0747@1|root,COG0747@2|Bacteria	2|Bacteria	E	dipeptide transport	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_723465_1	1121948.AUAC01000004_gene152	7.62e-34	130.0	COG1216@1|root,COG1216@2|Bacteria,1R6SJ@1224|Proteobacteria,2U47V@28211|Alphaproteobacteria,43W7J@69657|Hyphomonadaceae	28211|Alphaproteobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
k59_612227_1	710111.FraQA3DRAFT_2859	8.03e-36	137.0	COG0771@1|root,COG0771@2|Bacteria,2GJZA@201174|Actinobacteria,4ERI0@85013|Frankiales	201174|Actinobacteria	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	iNJ661.Rv2155c	AlaDh_PNT_C,Mur_ligase_C,Mur_ligase_M
k59_334233_1	1342299.Z947_120	1.1e-30	119.0	COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,2TU0R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Hydrolase CocE NonD family	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
k59_334233_2	1120983.KB894571_gene2480	1.26e-33	127.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,2TSR0@28211|Alphaproteobacteria,1JPCC@119043|Rhodobiaceae	28211|Alphaproteobacteria	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
k59_779031_1	1382306.JNIM01000001_gene257	1.64e-55	189.0	COG0593@1|root,COG0593@2|Bacteria,2G5W8@200795|Chloroflexi	200795|Chloroflexi	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
k59_389868_1	86416.Clopa_0410	2.67e-47	162.0	COG0253@1|root,COG0253@2|Bacteria,1TPMN@1239|Firmicutes,24AGY@186801|Clostridia,36EBG@31979|Clostridiaceae	186801|Clostridia	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	-	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
k59_1446204_1	204669.Acid345_2300	8.17e-29	118.0	COG5316@1|root,COG5316@2|Bacteria,3Y46P@57723|Acidobacteria,2JMJ4@204432|Acidobacteriia	204432|Acidobacteriia	S	Domain of unknown function (DUF4139)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139
k59_56313_1	713586.KB900536_gene2659	2.41e-95	290.0	COG2801@1|root,COG2801@2|Bacteria,1N207@1224|Proteobacteria,1S1FB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_28,HTH_32,LZ_Tnp_IS481,rve,rve_3
k59_1670250_1	671143.DAMO_2624	2.45e-99	314.0	COG0466@1|root,COG0466@2|Bacteria,2NNNN@2323|unclassified Bacteria	2|Bacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_1336684_1	742725.HMPREF9450_00464	8.33e-43	155.0	COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,4NDVV@976|Bacteroidetes,2FMFI@200643|Bacteroidia,22U0G@171550|Rikenellaceae	976|Bacteroidetes	S	Belongs to the CinA family	cinA	-	3.5.1.42	ko:K03742,ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
k59_113579_1	592015.HMPREF1705_02374	3.79e-19	85.1	COG0035@1|root,COG0698@1|root,COG0035@2|Bacteria,COG0698@2|Bacteria,3T9RJ@508458|Synergistetes	508458|Synergistetes	F	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate	upp	-	2.4.2.9	ko:K00761	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000	-	-	-	LacAB_rpiB,UPRTase
k59_335873_1	1192034.CAP_1063	1.86e-88	270.0	COG0863@1|root,COG0863@2|Bacteria	2|Bacteria	L	N-4 methylation of cytosine	-	-	2.1.1.72	ko:K00571,ko:K03497	-	-	-	-	ko00000,ko01000,ko02048,ko03000,ko03036,ko04812	-	-	-	N6_N4_Mtase,ParBc,RE_Eco29kI
k59_58053_1	948106.AWZT01000075_gene4896	1.58e-12	72.4	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2VHBT@28216|Betaproteobacteria,1K4NQ@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19,TPR_8,Trans_reg_C
k59_947573_1	1120792.JAFV01000001_gene1773	2.08e-97	306.0	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,2TRGS@28211|Alphaproteobacteria,36YMH@31993|Methylocystaceae	28211|Alphaproteobacteria	E	FAD dependent oxidoreductase central domain	Sardh	GO:0000166,GO:0001505,GO:0003674,GO:0003824,GO:0005488,GO:0005542,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006520,GO:0006575,GO:0006576,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008480,GO:0009056,GO:0009063,GO:0009308,GO:0009310,GO:0009987,GO:0016054,GO:0016491,GO:0016645,GO:0019695,GO:0019752,GO:0019842,GO:0031406,GO:0031974,GO:0033218,GO:0034641,GO:0035999,GO:0036094,GO:0042133,GO:0042135,GO:0042219,GO:0042402,GO:0042426,GO:0042558,GO:0043167,GO:0043168,GO:0043177,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0046483,GO:0046653,GO:0046997,GO:0048037,GO:0050660,GO:0050662,GO:0051186,GO:0055114,GO:0065007,GO:0065008,GO:0070013,GO:0071704,GO:0072341,GO:0097159,GO:0097164,GO:1901052,GO:1901053,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.5.3.19	ko:K19191	ko00760,ko01120,map00760,map01120	-	R10102	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO,FAO_M,GCV_T,GCV_T_C
k59_502793_1	582744.Msip34_0320	2e-15	70.5	COG1841@1|root,COG1841@2|Bacteria,1N6ZE@1224|Proteobacteria,2VVPT@28216|Betaproteobacteria,2KNAI@206350|Nitrosomonadales	206350|Nitrosomonadales	J	TIGRFAM ribosomal protein L30	rpmD	-	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
k59_502793_2	290398.Csal_0438	4.62e-23	94.4	COG0098@1|root,COG0098@2|Bacteria,1MUS4@1224|Proteobacteria,1RNEV@1236|Gammaproteobacteria,1XHWV@135619|Oceanospirillales	135619|Oceanospirillales	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	-	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
k59_280398_2	1089548.KI783301_gene1899	2.46e-30	118.0	COG0001@1|root,COG0001@2|Bacteria,1TPNH@1239|Firmicutes,4HANQ@91061|Bacilli,3WFAP@539002|Bacillales incertae sedis	91061|Bacilli	H	intramolecular transferase activity, transferring amino groups	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iSB619.SA_RS08395	Aminotran_3
k59_224783_1	1049564.TevJSym_bf00250	1.26e-25	110.0	COG2304@1|root,COG3509@1|root,COG4257@1|root,COG2304@2|Bacteria,COG3509@2|Bacteria,COG4257@2|Bacteria,1PDQV@1224|Proteobacteria,1RPGD@1236|Gammaproteobacteria,1J904@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	V	Integrin alpha (beta-propellor repeats).	-	-	-	-	-	-	-	-	-	-	-	-	DUF5011,FG-GAP_2
k59_2542_1	614083.AWQR01000005_gene1144	4.2e-22	96.3	COG0451@1|root,COG0451@2|Bacteria,1MVE4@1224|Proteobacteria,2VH69@28216|Betaproteobacteria,4AC04@80864|Comamonadaceae	28216|Betaproteobacteria	F	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose	hldD	-	5.1.3.20	ko:K03274	ko00540,ko01100,map00540,map01100	M00064	R05176	RC01291	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase
k59_224797_1	999541.bgla_2g29830	4.42e-06	49.3	COG2128@1|root,COG2128@2|Bacteria,1RG50@1224|Proteobacteria,2W1HE@28216|Betaproteobacteria,1KG0H@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD
k59_224797_2	395965.Msil_2117	2.16e-28	109.0	COG1058@1|root,COG1058@2|Bacteria,1MVG6@1224|Proteobacteria,2TU5C@28211|Alphaproteobacteria,3NA7R@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	Probable molybdopterin binding domain	cinA1	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
k59_280430_1	767031.HMPREF9137_0964	2.44e-33	130.0	COG1216@1|root,COG1216@2|Bacteria,4NFW5@976|Bacteroidetes,2FQ14@200643|Bacteroidia	976|Bacteroidetes	S	Glycosyltransferase, group 2 family protein	wbbL	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glyco_tranf_2_3,Glyco_trans_2_3,Glycos_transf_2
k59_1114513_1	488538.SAR116_2179	7.08e-73	228.0	COG0730@1|root,COG0730@2|Bacteria,1MWX2@1224|Proteobacteria,2TRIC@28211|Alphaproteobacteria,4BPDR@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	membrane transporter protein	MA20_19835	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
k59_558305_3	1122613.ATUP01000001_gene1496	2.07e-19	85.5	COG1335@1|root,COG1335@2|Bacteria,1N48X@1224|Proteobacteria,2U17G@28211|Alphaproteobacteria,43YZU@69657|Hyphomonadaceae	28211|Alphaproteobacteria	Q	COG1335 Amidases related to nicotinamidase	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
k59_780792_1	1177181.T9A_02388	1.11e-94	291.0	COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,1RMD2@1236|Gammaproteobacteria,1XHHA@135619|Oceanospirillales	135619|Oceanospirillales	E	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate	alkJ2	-	1.1.99.1	ko:K00108	ko00260,ko01100,map00260,map01100	M00555	R01025	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
k59_113648_1	317936.Nos7107_3546	1.98e-15	73.9	COG0703@1|root,COG0703@2|Bacteria,1GJPH@1117|Cyanobacteria,1HS8A@1161|Nostocales	1117|Cyanobacteria	E	Shikimate kinase	-	-	-	-	-	-	-	-	-	-	-	-	SKI
k59_113648_2	1333523.L593_10490	4.84e-11	66.2	COG0618@1|root,arCOG01566@2157|Archaea,2XSWT@28890|Euryarchaeota,23SZI@183963|Halobacteria	183963|Halobacteria	S	COG1226 Kef-type K transport systems	-	-	-	-	-	-	-	-	-	-	-	-	DHH,DHHA1,TrkA_N
k59_725336_1	398525.KB900701_gene7034	5.4e-09	62.4	COG2433@1|root,COG2433@2|Bacteria,1QW6M@1224|Proteobacteria,2TWQ2@28211|Alphaproteobacteria,3JRK5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Pfam Transposase IS66	MA20_46300	-	-	-	-	-	-	-	-	-	-	-	-
k59_1392194_1	979556.MTES_3297	1.13e-37	142.0	COG0389@1|root,COG0389@2|Bacteria,2GKBI@201174|Actinobacteria,4FKWX@85023|Microbacteriaceae	201174|Actinobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	HHH_5,IMS,IMS_C,IMS_HHH
k59_280464_1	1196323.ALKF01000162_gene4738	2.55e-35	124.0	COG3870@1|root,COG3870@2|Bacteria,1V6NI@1239|Firmicutes,4HIHA@91061|Bacilli,26XJT@186822|Paenibacillaceae	91061|Bacilli	S	Cyclic-di-AMP receptor	yaaQ	-	-	-	-	-	-	-	-	-	-	-	CdAMP_rec
k59_502873_1	1313172.YM304_16940	4.04e-92	286.0	COG3119@1|root,COG3119@2|Bacteria,2GJ8H@201174|Actinobacteria	201174|Actinobacteria	P	Pfam Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
k59_2611_1	546266.NEIMUCOT_05484	1.33e-33	125.0	COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,2VJ6H@28216|Betaproteobacteria,2KPX2@206351|Neisseriales	206351|Neisseriales	F	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor	pyrD	-	1.3.5.2	ko:K00254	ko00240,ko01100,map00240,map01100	M00051	R01868	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
k59_558334_1	671143.DAMO_0088	2.23e-42	156.0	COG3276@1|root,COG3276@2|Bacteria,2NNQU@2323|unclassified Bacteria	2|Bacteria	J	Elongation factor SelB, winged helix	selB	-	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3
k59_335963_2	580340.Tlie_1655	2.62e-26	106.0	COG0451@1|root,COG0451@2|Bacteria,3T9U6@508458|Synergistetes	508458|Synergistetes	M	NAD dependent epimerase dehydratase family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
k59_1392214_2	861299.J421_0477	9.35e-36	132.0	COG0859@1|root,COG0859@2|Bacteria,1ZT3G@142182|Gemmatimonadetes	2|Bacteria	M	Glycosyltransferase family 9 (heptosyltransferase)	opsX	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	-	ko:K02841,ko:K02843,ko:K02849,ko:K12982	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
k59_280494_2	1273538.G159_16680	1.22e-05	52.0	COG1088@1|root,COG1088@2|Bacteria,1TPWM@1239|Firmicutes,4HA3Y@91061|Bacilli,26EPN@186818|Planococcaceae	91061|Bacilli	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily	-	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
k59_224875_1	596151.DesfrDRAFT_2997	7.78e-09	60.5	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WIR4@28221|Deltaproteobacteria,2M8AY@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4,PAS_9,Response_reg
k59_1670381_1	65497.JODV01000021_gene2136	5.02e-27	105.0	COG0262@1|root,COG0262@2|Bacteria,2GKX0@201174|Actinobacteria,4E351@85010|Pseudonocardiales	201174|Actinobacteria	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
k59_1670381_2	666686.B1NLA3E_11620	1.95e-25	101.0	COG3865@1|root,COG3865@2|Bacteria,1TP7B@1239|Firmicutes,4HDPM@91061|Bacilli,1ZR5K@1386|Bacillus	91061|Bacilli	S	3-demethylubiquinone-9 3-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	3-dmu-9_3-mt
k59_1225845_1	204669.Acid345_0343	9.03e-85	261.0	COG1085@1|root,COG1085@2|Bacteria,3Y41K@57723|Acidobacteria,2JMKJ@204432|Acidobacteriia	204432|Acidobacteriia	C	Domain of unknown function (DUF4921)	-	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	GalP_UDP_tr_C
k59_1281244_1	1168065.DOK_13194	3.96e-70	222.0	COG2141@1|root,COG2141@2|Bacteria,1R76K@1224|Proteobacteria,1RQYQ@1236|Gammaproteobacteria,1J5B4@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_335991_1	525904.Tter_0799	4.22e-59	189.0	COG2197@1|root,COG2197@2|Bacteria,2NQFJ@2323|unclassified Bacteria	2|Bacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_502924_1	1294143.H681_04485	1.28e-121	356.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,1RMAQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_892165_1	110319.CF8_3522	2.01e-37	137.0	COG4177@1|root,COG4177@2|Bacteria,2GMGD@201174|Actinobacteria,4DNIE@85009|Propionibacteriales	201174|Actinobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_892165_2	882083.SacmaDRAFT_5689	4.21e-29	114.0	COG0559@1|root,COG0559@2|Bacteria,2HDZ9@201174|Actinobacteria,4DZD5@85010|Pseudonocardiales	201174|Actinobacteria	U	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_1670402_1	570952.ATVH01000011_gene241	1.01e-10	67.0	COG3087@1|root,COG3087@2|Bacteria,1MXII@1224|Proteobacteria,2TTG3@28211|Alphaproteobacteria,2JT9Z@204441|Rhodospirillales	204441|Rhodospirillales	D	Sporulation related domain	-	-	-	-	-	-	-	-	-	-	-	-	SPOR
k59_224898_1	380394.Lferr_1427	5.62e-56	176.0	COG2963@1|root,COG2963@2|Bacteria,1N1AA@1224|Proteobacteria,1S5XP@1236|Gammaproteobacteria,2ND6D@225057|Acidithiobacillales	225057|Acidithiobacillales	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
k59_1448137_2	1279009.ADICEAN_00473	4.32e-06	52.0	COG1629@1|root,COG4206@1|root,COG4206@2|Bacteria,COG4771@2|Bacteria,4NDU8@976|Bacteroidetes,47KVA@768503|Cytophagia	976|Bacteroidetes	HP	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
k59_780876_1	204669.Acid345_1339	1.23e-50	172.0	COG2912@1|root,COG2912@2|Bacteria,3Y53Z@57723|Acidobacteria,2JMYF@204432|Acidobacteriia	204432|Acidobacteriia	S	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	TPR_9,Transglut_core2
k59_502932_1	1449347.JQLN01000005_gene5089	6.58e-27	110.0	COG0442@1|root,COG0442@2|Bacteria,2GJ9G@201174|Actinobacteria,2M0SA@2063|Kitasatospora	201174|Actinobacteria	J	Aminoacyl-tRNA editing domain	proS	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
k59_502937_1	710696.Intca_3460	3.21e-12	62.8	COG3651@1|root,COG3651@2|Bacteria,2IHNI@201174|Actinobacteria,4FH7J@85021|Intrasporangiaceae	201174|Actinobacteria	S	Uncharacterized protein conserved in bacteria (DUF2237)	-	-	-	ko:K09966	-	-	-	-	ko00000	-	-	-	DUF2237
k59_502937_2	1068980.ARVW01000001_gene5682	1.7e-36	139.0	COG0028@1|root,COG0028@2|Bacteria,2GM6Y@201174|Actinobacteria,4DXB8@85010|Pseudonocardiales	201174|Actinobacteria	EH	Belongs to the TPP enzyme family	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_892180_1	1449126.JQKL01000003_gene1813	1.39e-36	139.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,26A1J@186813|unclassified Clostridiales	186801|Clostridia	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
k59_1559181_1	1268622.AVS7_02191	1.27e-14	76.6	COG2084@1|root,COG2084@2|Bacteria,1MX8V@1224|Proteobacteria,2VMCM@28216|Betaproteobacteria,4ADV6@80864|Comamonadaceae	28216|Betaproteobacteria	I	Domain of unknown function (DUF1932)	-	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	DUF1932,NAD_binding_2
k59_1559181_2	640081.Dsui_0500	4.65e-10	60.5	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2VIA1@28216|Betaproteobacteria,2KVJT@206389|Rhodocyclales	206389|Rhodocyclales	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	spoT	-	2.7.6.5,3.1.7.2	ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
k59_1392267_1	566466.NOR53_3566	1.08e-230	648.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,1S01K@1236|Gammaproteobacteria,1J7W3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	L COG3666 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_614066_1	266779.Meso_3378	7.48e-62	192.0	COG1146@1|root,COG1146@2|Bacteria,1RH5I@1224|Proteobacteria,2U98K@28211|Alphaproteobacteria,43K14@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions	fdxA	-	-	ko:K05524	-	-	-	-	ko00000	-	-	-	DUF3470,Fer4,Fer4_4
k59_836428_2	28072.Nos7524_0684	1.52e-11	61.2	2DRDY@1|root,33BC0@2|Bacteria,1G9R7@1117|Cyanobacteria,1HPI3@1161|Nostocales	1117|Cyanobacteria	S	PFAM Coenzyme PQQ synthesis protein D (PqqD)	-	-	-	-	-	-	-	-	-	-	-	-	PqqD
k59_892187_1	1128421.JAGA01000001_gene2365	3.84e-10	62.4	COG1600@1|root,COG1600@2|Bacteria,2NNWV@2323|unclassified Bacteria	2|Bacteria	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	queG	GO:0003674,GO:0003824,GO:0006091,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009055,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0022900,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Fer4_16
k59_1336856_1	580332.Slit_1269	2.93e-27	114.0	COG2114@1|root,COG2114@2|Bacteria,1RD0X@1224|Proteobacteria,2VS0D@28216|Betaproteobacteria,44VWF@713636|Nitrosomonadales	28216|Betaproteobacteria	T	adenylyl cyclase class-3 4 guanylyl cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,PEGA
k59_558402_1	1379698.RBG1_1C00001G1656	7.57e-93	300.0	COG0653@1|root,COG0653@2|Bacteria,2NNRK@2323|unclassified Bacteria	2|Bacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_558404_1	357808.RoseRS_3183	1.61e-55	187.0	COG1721@1|root,COG1721@2|Bacteria,2G7JJ@200795|Chloroflexi	200795|Chloroflexi	M	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
k59_294162_1	1128421.JAGA01000002_gene465	1.81e-06	55.1	COG0404@1|root,COG0404@2|Bacteria	2|Bacteria	E	The glycine cleavage system catalyzes the degradation of glycine	-	-	1.5.99.5,2.1.2.10	ko:K00605,ko:K06980,ko:K22086	ko00260,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200	M00532	R00609,R01221,R02300,R04125	RC00022,RC00069,RC00183,RC00190,RC00557,RC02834	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	GCV_T,GCV_T_C
k59_182460_2	1123054.KB907710_gene904	3.44e-35	136.0	COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,1WXQ0@135613|Chromatiales	135613|Chromatiales	P	Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,TrkA_C
k59_461508_1	1246995.AFR_09940	2.45e-36	137.0	COG0128@1|root,COG0128@2|Bacteria,2GJKX@201174|Actinobacteria,4DB3A@85008|Micromonosporales	201174|Actinobacteria	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
k59_516579_1	1168289.AJKI01000065_gene3755	2.84e-85	276.0	COG1472@1|root,COG1472@2|Bacteria,4NE90@976|Bacteroidetes,2FNZH@200643|Bacteroidia,3XKGR@558415|Marinilabiliaceae	976|Bacteroidetes	G	Fibronectin type III-like domain	bglB	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
k59_1741143_2	1242864.D187_003642	5.54e-21	89.7	COG1670@1|root,COG1670@2|Bacteria,1P18R@1224|Proteobacteria	2|Bacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
k59_1574482_1	701347.Entcl_2607	6.85e-05	46.6	COG0709@1|root,COG0709@2|Bacteria,1MWFG@1224|Proteobacteria,1RQ5Q@1236|Gammaproteobacteria,3X0QF@547|Enterobacter	1236|Gammaproteobacteria	F	Synthesizes selenophosphate from selenide and ATP	selD	GO:0000287,GO:0001887,GO:0003674,GO:0003824,GO:0004756,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009451,GO:0009987,GO:0010467,GO:0016053,GO:0016070,GO:0016259,GO:0016260,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016781,GO:0019752,GO:0034470,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0070329,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	iPC815.YPO2164,iSFV_1184.SFV_1453,iSF_1195.SF1459,iSFxv_1172.SFxv_1645,iS_1188.S1574	AIRS,AIRS_C
k59_1574482_2	1122194.AUHU01000005_gene1007	3.17e-35	126.0	COG2755@1|root,COG2755@2|Bacteria,1RCXZ@1224|Proteobacteria,1S3QU@1236|Gammaproteobacteria,466ZZ@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	COG2755 Lysophospholipase L1 and related esterases	tesA	GO:0003674,GO:0003824,GO:0004620,GO:0004622,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016289,GO:0016290,GO:0016298,GO:0016787,GO:0016788,GO:0016790,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0042802,GO:0043170,GO:0044238,GO:0044464,GO:0047617,GO:0052689,GO:0071704,GO:0140096,GO:1901564	3.1.1.5	ko:K10804	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	iECED1_1282.ECED1_0521,iLF82_1304.LF82_2242,iNRG857_1313.NRG857_02365	Lipase_GDSL_2
k59_1185351_1	247634.GPB2148_1538	4.39e-27	114.0	COG4774@1|root,COG4774@2|Bacteria,1NMCN@1224|Proteobacteria,1T239@1236|Gammaproteobacteria,1J4TJ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	COG1629 Outer membrane receptor proteins, mostly Fe transport	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
k59_628823_1	926569.ANT_31720	1.2e-37	138.0	COG2987@1|root,COG2987@2|Bacteria,2G5PQ@200795|Chloroflexi	200795|Chloroflexi	E	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
k59_463538_1	1454010.JEOE01000018_gene1203	2.7e-07	52.0	COG0640@1|root,COG0640@2|Bacteria,2IQDH@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
k59_963210_1	671143.DAMO_1648	3.53e-76	237.0	COG3494@1|root,COG3494@2|Bacteria,2NR94@2323|unclassified Bacteria	2|Bacteria	S	Protein of unknown function (DUF1009)	cdsA2	GO:0003674,GO:0003824,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008758,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.4.1.182	ko:K00748,ko:K09949	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	-	DUF1009
k59_1185365_1	379066.GAU_1738	8.28e-103	313.0	COG0034@1|root,COG0034@2|Bacteria,1ZTD7@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6
k59_685777_1	1239962.C943_02799	8.57e-30	126.0	COG2114@1|root,COG3292@1|root,COG2114@2|Bacteria,COG3292@2|Bacteria,4NEVN@976|Bacteroidetes,47MR3@768503|Cytophagia	976|Bacteroidetes	T	Belongs to the adenylyl cyclase class-4 guanylyl cyclase family	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	7TMR-DISM_7TM,Guanylate_cyc,Reg_prop,Response_reg,TPR_12,Y_Y_Y
k59_1407929_1	928724.SacglDRAFT_02183	1.41e-36	140.0	COG0339@1|root,COG0339@2|Bacteria,2GM2Z@201174|Actinobacteria,4E24H@85010|Pseudonocardiales	201174|Actinobacteria	E	PFAM Peptidase family M3	dcp	-	3.4.15.5	ko:K01284	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
k59_1074005_1	1547437.LL06_17135	5.98e-27	114.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,2TSR0@28211|Alphaproteobacteria,43GY1@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
k59_350911_1	1124780.ANNU01000002_gene1606	1.45e-16	84.7	COG0642@1|root,COG3292@1|root,COG2205@2|Bacteria,COG3292@2|Bacteria,4NKGA@976|Bacteroidetes,47TQU@768503|Cytophagia	976|Bacteroidetes	T	Stage II sporulation protein E (SpoIIE)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Reg_prop,SpoIIE,Y_Y_Y
k59_128339_2	379066.GAU_1887	8.6e-50	165.0	COG0669@1|root,COG0669@2|Bacteria,1ZTTQ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
k59_128339_3	1045004.OKIT_1836	3.21e-05	46.2	COG0280@1|root,COG0280@2|Bacteria,1TPQ0@1239|Firmicutes,4H9VH@91061|Bacilli,4AWST@81850|Leuconostocaceae	91061|Bacilli	C	phosphate acetyltransferase	pta	-	2.3.1.8,3.6.3.21	ko:K00625,ko:K02028	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00236,M00357,M00579	R00230,R00921	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3	-	iSB619.SA_RS03155	PTA_PTB
k59_1074019_1	305900.GV64_22965	3.34e-96	284.0	COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,1RQ38@1236|Gammaproteobacteria,1XI4I@135619|Oceanospirillales	135619|Oceanospirillales	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
k59_1019326_2	309800.C498_10046	1.03e-13	73.6	COG3839@1|root,arCOG00177@2157|Archaea,2XSVD@28890|Euryarchaeota,23SSF@183963|Halobacteria	183963|Halobacteria	E	COG3839 ABC-type sugar transport systems, ATPase components	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE_2
k59_908316_1	278963.ATWD01000001_gene4496	5.6e-24	106.0	COG0577@1|root,COG0577@2|Bacteria,3Y6C8@57723|Acidobacteria,2JMHC@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_1574540_1	1282876.BAOK01000001_gene3566	1.41e-59	191.0	COG0135@1|root,COG0135@2|Bacteria,1RA87@1224|Proteobacteria,2U7CH@28211|Alphaproteobacteria,4BQMQ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	N-(5'phosphoribosyl)anthranilate (PRA) isomerase	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
k59_908318_2	575540.Isop_1666	3.78e-17	81.3	COG0793@1|root,COG0793@2|Bacteria	2|Bacteria	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S41,Tricorn_C1
k59_740998_1	742743.HMPREF9453_00095	8.42e-19	90.5	COG4666@1|root,COG4666@2|Bacteria,1TP0V@1239|Firmicutes,4H3FG@909932|Negativicutes	909932|Negativicutes	S	TRAP transporter, 4TM 12TM fusion protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3394,DctM
k59_350934_2	335541.Swol_1301	1.18e-48	168.0	COG3635@1|root,COG3635@2|Bacteria,1TQ5S@1239|Firmicutes,248U6@186801|Clostridia,42JI0@68298|Syntrophomonadaceae	186801|Clostridia	G	2,3-bisphosphoglycerate-independent phosphoglycerate mutase	-	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
k59_1130547_1	321955.AAGP01000003_gene2912	1.13e-10	67.4	COG0210@1|root,COG2887@1|root,COG0210@2|Bacteria,COG2887@2|Bacteria,2GJD0@201174|Actinobacteria,4F96D@85019|Brevibacteriaceae	201174|Actinobacteria	L	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	AAA_19,PDDEXK_1,UvrD-helicase,UvrD_C
k59_1074031_1	762376.AXYL_01255	9.3e-12	69.3	COG3181@1|root,COG3181@2|Bacteria,1R8ZB@1224|Proteobacteria,2VHN1@28216|Betaproteobacteria,3T725@506|Alcaligenaceae	28216|Betaproteobacteria	S	Extra-cytoplasmic solute receptor family protein 24	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_1130552_1	1056820.KB900685_gene2797	3.74e-19	85.9	COG1215@1|root,COG1215@2|Bacteria,1QUG1@1224|Proteobacteria,1RZH7@1236|Gammaproteobacteria,2PQ9F@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	M	Glycosyl transferase family group 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_1074039_1	864051.BurJ1DRAFT_4870	9.23e-14	73.2	COG1192@1|root,COG1192@2|Bacteria,1QBJX@1224|Proteobacteria,2VJNI@28216|Betaproteobacteria,1KKPC@119065|unclassified Burkholderiales	28216|Betaproteobacteria	D	ATPase MipZ	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31,CbiA
k59_1185427_1	314225.ELI_14900	1.85e-114	335.0	COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,2K2F6@204457|Sphingomonadales	204457|Sphingomonadales	L	COG2801 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve,rve_3
k59_18223_1	655815.ZPR_1379	0.000196	45.8	COG1506@1|root,COG1506@2|Bacteria,4NE2Q@976|Bacteroidetes,1HWSF@117743|Flavobacteriia	976|Bacteroidetes	E	COG1506 Dipeptidyl aminopeptidases acylaminoacyl-peptidases	-	-	-	-	-	-	-	-	-	-	-	-	DPPIV_N,Peptidase_S9
k59_741036_1	3218.PP1S314_12V6.1	8.8e-05	50.1	COG0668@1|root,2QRDM@2759|Eukaryota,37MGH@33090|Viridiplantae,3GAT0@35493|Streptophyta	35493|Streptophyta	M	Mechanosensitive ion channel protein 1	-	GO:0003674,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006810,GO:0006950,GO:0006979,GO:0008150,GO:0008381,GO:0009507,GO:0009526,GO:0009536,GO:0009941,GO:0009987,GO:0015267,GO:0016020,GO:0019866,GO:0022803,GO:0022836,GO:0022857,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0033554,GO:0034599,GO:0042221,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044429,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0070887	-	ko:K22047	-	-	-	-	ko00000,ko02000	1.A.23.4	-	-	MS_channel
k59_741048_1	1121405.dsmv_2280	1.86e-82	250.0	COG0395@1|root,COG0395@2|Bacteria,1N4I0@1224|Proteobacteria,43AKX@68525|delta/epsilon subdivisions,2X612@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
k59_518526_1	1382356.JQMP01000003_gene1881	1.15e-10	65.1	COG1009@1|root,COG1009@2|Bacteria,2G5NJ@200795|Chloroflexi,27XR2@189775|Thermomicrobia	189775|Thermomicrobia	C	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus	-	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
k59_463640_2	1165096.ARWF01000001_gene165	1.49e-18	87.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2VHCZ@28216|Betaproteobacteria,2KKBT@206350|Nitrosomonadales	206350|Nitrosomonadales	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_18257_1	398720.MED217_11554	5.37e-62	205.0	COG2017@1|root,COG2017@2|Bacteria,4NF5G@976|Bacteroidetes,1HZCR@117743|Flavobacteriia,2XIUC@283735|Leeuwenhoekiella	976|Bacteroidetes	G	Aldose 1-epimerase	-	-	5.1.3.3	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	M00632	R01602,R10619	RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldose_epim
k59_351000_1	880073.Calab_2811	1.58e-34	135.0	COG0038@1|root,COG0517@1|root,COG0038@2|Bacteria,COG0517@2|Bacteria,2NPC4@2323|unclassified Bacteria	2|Bacteria	P	Voltage gated chloride channel	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	iAF987.Gmet_3470	CBS,TrkA_C,Voltage_CLC
k59_128436_2	1217720.ALOX01000054_gene2230	1.47e-05	48.5	2E4J2@1|root,32ZE4@2|Bacteria,1N7YM@1224|Proteobacteria,2UBV9@28211|Alphaproteobacteria,2JU1G@204441|Rhodospirillales	204441|Rhodospirillales	S	Protein of unknown function (DUF3775)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3775
k59_1463701_1	1280946.HY29_14775	2e-58	186.0	COG0349@1|root,COG0349@2|Bacteria,1MWFD@1224|Proteobacteria,2TQXS@28211|Alphaproteobacteria,43WZZ@69657|Hyphomonadaceae	28211|Alphaproteobacteria	L	exonuclease	rnd1	-	3.1.13.5	ko:K03684	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DNA_pol_A_exo1
k59_1629548_1	1122915.AUGY01000017_gene2509	4.93e-63	216.0	COG1048@1|root,COG1048@2|Bacteria,1VTMM@1239|Firmicutes,4HB5N@91061|Bacilli,26R9T@186822|Paenibacillaceae	91061|Bacilli	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	acnA	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k59_1741285_1	1173028.ANKO01000112_gene4786	2.87e-86	265.0	COG5379@1|root,COG5379@2|Bacteria,1GC1E@1117|Cyanobacteria,1HEN7@1150|Oscillatoriales	1117|Cyanobacteria	I	Protein of unknown function (DUF3419)	-	-	-	ko:K13622	ko00564,map00564	-	R09072	RC00021,RC01091	ko00000,ko00001	-	-	-	DUF3419
k59_240573_1	1124982.MSI_01390	0.000136	43.5	COG0587@1|root,COG0587@2|Bacteria,2J5B5@203691|Spirochaetes	203691|Spirochaetes	L	DNA-directed DNA polymerase	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_240573_2	552811.Dehly_0662	8.81e-115	346.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,2G5WB@200795|Chloroflexi,34CZX@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
k59_1685960_1	926569.ANT_09200	6.38e-42	156.0	COG0568@1|root,COG0568@2|Bacteria,2G5W3@200795|Chloroflexi	200795|Chloroflexi	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_1074155_2	264462.Bd0137	1.34e-48	169.0	COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,42M3S@68525|delta/epsilon subdivisions,2MSRP@213481|Bdellovibrionales,2WJVZ@28221|Deltaproteobacteria	213481|Bdellovibrionales	T	elongation factor Tu domain 2 protein	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
k59_685934_1	1449065.JMLL01000015_gene4278	2.99e-85	270.0	COG2766@1|root,COG2766@2|Bacteria,1MVW7@1224|Proteobacteria,2TTW4@28211|Alphaproteobacteria,43H0J@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	T	serine protein kinase	yeaG	-	-	ko:K07180	-	-	-	-	ko00000	-	-	-	AAA_PrkA,PrkA
k59_796691_1	479434.Sthe_1921	3.35e-30	116.0	COG0294@1|root,COG0294@2|Bacteria,2G6A6@200795|Chloroflexi,27XJT@189775|Thermomicrobia	189775|Thermomicrobia	H	Pterin binding enzyme	-	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
k59_1074174_1	246196.MSMEI_2432	3.71e-12	71.6	COG0624@1|root,COG0624@2|Bacteria,2I8IJ@201174|Actinobacteria,238BU@1762|Mycobacteriaceae	201174|Actinobacteria	E	Peptidase family M20/M25/M40	argE	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
k59_1463756_1	330214.NIDE2714	5.25e-42	145.0	COG0250@1|root,COG0250@2|Bacteria,3J17S@40117|Nitrospirae	40117|Nitrospirae	K	Transcription termination factor nusG	-	-	-	-	-	-	-	-	-	-	-	-	NusG
k59_351065_1	610130.Closa_1081	1.01e-28	117.0	COG1306@1|root,COG1306@2|Bacteria,1TQZV@1239|Firmicutes,24ADG@186801|Clostridia,21YAT@1506553|Lachnoclostridium	186801|Clostridia	S	Putative glycosyl hydrolase domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4015
k59_963382_1	877418.ATWV01000008_gene688	1.81e-27	118.0	COG3547@1|root,COG3547@2|Bacteria,2J8TB@203691|Spirochaetes	203691|Spirochaetes	L	Transposase IS116/IS110/IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1130679_1	1122917.KB899679_gene451	2.08e-34	128.0	COG0084@1|root,COG0084@2|Bacteria,1TNY1@1239|Firmicutes,4HA74@91061|Bacilli,26RCQ@186822|Paenibacillaceae	91061|Bacilli	L	Hydrolase, tatd	tatD	GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
k59_296163_1	518766.Rmar_1440	9.35e-07	50.4	COG0845@1|root,COG0845@2|Bacteria,4NFT4@976|Bacteroidetes	976|Bacteroidetes	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23,OEP
k59_296163_2	1121007.AUML01000004_gene2443	6.88e-18	87.8	COG0577@1|root,COG0577@2|Bacteria,4NFUG@976|Bacteroidetes,1HZ09@117743|Flavobacteriia,2YGQR@290174|Aquimarina	976|Bacteroidetes	V	MacB-like periplasmic core domain	macB_3	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_1685992_1	547163.BN979_05074	1.94e-20	92.0	COG0672@1|root,COG0672@2|Bacteria,2GJ22@201174|Actinobacteria,235WY@1762|Mycobacteriaceae	201174|Actinobacteria	P	Iron permease FTR1	-	-	-	ko:K07243	-	-	-	-	ko00000,ko02000	2.A.108.1,2.A.108.2	-	-	FTR1
k59_1574691_1	518766.Rmar_1284	2.03e-49	169.0	COG1018@1|root,COG1018@2|Bacteria,4PEIX@976|Bacteroidetes,1FJ74@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	C	Oxidoreductase NAD-binding domain	-	-	1.18.1.2,1.19.1.1	ko:K00528	-	-	R10159	-	ko00000,ko01000	-	-	-	FAD_binding_6,NAD_binding_1
k59_1185559_1	1487953.JMKF01000079_gene4188	9.68e-25	107.0	COG4671@1|root,COG4671@2|Bacteria,1G142@1117|Cyanobacteria,1H7A9@1150|Oscillatoriales	1117|Cyanobacteria	S	Glycosyl transferase family 1	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_963399_1	545276.KB898732_gene2442	1.2e-32	121.0	COG0735@1|root,COG0735@2|Bacteria,1RH58@1224|Proteobacteria,1SAXA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	belongs to the Fur family	-	-	-	ko:K09826	-	-	-	-	ko00000,ko03000	-	-	-	FUR
k59_908502_1	690850.Desaf_0167	8e-13	68.2	arCOG06766@1|root,2Z87F@2|Bacteria,1R8CC@1224|Proteobacteria,43F1F@68525|delta/epsilon subdivisions,2X2ZM@28221|Deltaproteobacteria,2M9TP@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_240639_1	518766.Rmar_0118	7.03e-102	311.0	COG2939@1|root,COG2939@2|Bacteria,4NF48@976|Bacteroidetes,1FJ5Z@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	M	Serine carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S10
k59_741171_1	926569.ANT_14870	3.08e-63	218.0	COG0112@1|root,COG0404@1|root,COG0112@2|Bacteria,COG0404@2|Bacteria,2G624@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
k59_1408142_1	1121440.AUMA01000022_gene2037	7.07e-36	134.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,42M9N@68525|delta/epsilon subdivisions,2WIZR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	PFAM TRAP C4-dicarboxylate transport system permease DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_425428_1	525909.Afer_0907	1.61e-126	378.0	COG1222@1|root,COG1222@2|Bacteria,2GMR1@201174|Actinobacteria,4CMRU@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Proteasomal ATPase OB/ID domain	arc	-	-	ko:K13527	ko03050,map03050	M00342	-	-	ko00000,ko00001,ko00002,ko03051	-	-	-	AAA,Prot_ATP_ID_OB
k59_814642_1	1197951.I6S2A9_9CAUD	1.33e-59	204.0	4QCM5@10239|Viruses,4QVZY@35237|dsDNA viruses  no RNA stage,4QQFH@28883|Caudovirales	28883|Caudovirales	S	Bacteriophage head to tail connecting protein	-	GO:0005575,GO:0008150,GO:0016032,GO:0019012,GO:0019028,GO:0019058,GO:0019068,GO:0019072,GO:0019073,GO:0032991,GO:0044403,GO:0044419,GO:0044423,GO:0046798,GO:0051704	-	-	-	-	-	-	-	-	-	-	-
k59_1758230_1	768670.Calni_1647	6.33e-96	290.0	COG2805@1|root,COG2805@2|Bacteria,2GEWK@200930|Deferribacteres	200930|Deferribacteres	NU	Type II/IV secretion system protein	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
k59_1316765_1	339671.Asuc_1933	3.05e-36	138.0	COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,1RMIV@1236|Gammaproteobacteria,1Y6X7@135625|Pasteurellales	135625|Pasteurellales	M	Peptidoglycan polymerase that is essential for cell division	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
k59_983294_1	251229.Chro_1581	3.26e-51	180.0	COG1914@1|root,COG1914@2|Bacteria,1GIFV@1117|Cyanobacteria,3VM6A@52604|Pleurocapsales	1117|Cyanobacteria	P	H( )-stimulated, divalent metal cation uptake system	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1758236_1	1123240.ATVO01000005_gene1833	9.34e-08	57.0	COG1670@1|root,COG1670@2|Bacteria,1RCX2@1224|Proteobacteria,2U97G@28211|Alphaproteobacteria,2K59G@204457|Sphingomonadales	204457|Sphingomonadales	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
k59_1646710_1	3641.EOY19461	1.77e-41	155.0	COG0187@1|root,KOG0582@1|root,KOG4585@1|root,KOG0355@2759|Eukaryota,KOG0582@2759|Eukaryota,KOG4585@2759|Eukaryota,37SQ1@33090|Viridiplantae,3GH2J@35493|Streptophyta	35493|Streptophyta	B	DNA gyrase subunit A	-	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_201799_1	861299.J421_1874	1.7e-68	215.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
k59_646245_1	59538.XP_005968812.1	4.42e-78	243.0	COG0197@1|root,KOG3422@2759|Eukaryota,39S31@33154|Opisthokonta,3BPN3@33208|Metazoa	33208|Metazoa	J	Ribosomal protein S3, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	KH_2,Ribosomal_L16,Ribosomal_S3_C
k59_814680_2	1336237.JAEE01000001_gene1770	2.15e-09	63.9	COG0620@1|root,COG0620@2|Bacteria,1MV2Z@1224|Proteobacteria,1RPTM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	methionine synthase	yxjG	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
k59_315623_1	1379270.AUXF01000005_gene316	2.22e-08	61.6	COG5492@1|root,COG5492@2|Bacteria	2|Bacteria	N	domain, Protein	ligA1	-	-	-	-	-	-	-	-	-	-	-	Big_2
k59_1261608_1	234267.Acid_4160	4.71e-60	202.0	COG4962@1|root,COG4962@2|Bacteria,3Y360@57723|Acidobacteria	57723|Acidobacteria	U	PFAM type II secretion system protein E	-	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
k59_1706233_1	1535422.ND16A_0636	1.14e-31	124.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,1RMAQ@1236|Gammaproteobacteria,2Q7NY@267889|Colwelliaceae	1236|Gammaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1482706_1	1090320.KB900605_gene2144	2.96e-116	342.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,2K2SD@204457|Sphingomonadales	204457|Sphingomonadales	L	Transposase	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1039636_1	987059.RBXJA2T_03698	4.43e-54	186.0	COG2759@1|root,COG2759@2|Bacteria,1MUR8@1224|Proteobacteria,2VKR6@28216|Betaproteobacteria,1KIXT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Formate--tetrahydrofolate ligase	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
k59_1706237_1	749222.Nitsa_0867	1.94e-65	224.0	COG0474@1|root,COG0475@1|root,COG0474@2|Bacteria,COG0475@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2YNQF@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	P	COG0474 Cation transport ATPase	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3,Na_H_Exchanger
k59_201830_1	1146883.BLASA_1920	8.18e-75	250.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,4ERFZ@85013|Frankiales	201174|Actinobacteria	P	E1-E2 ATPase	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K12954,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3,3.A.3.5	-	-	Cupredoxin_1,E1-E2_ATPase,HMA,Hydrolase,YHS
k59_483469_2	1380394.JADL01000002_gene1605	1.31e-45	156.0	COG1028@1|root,COG1028@2|Bacteria,1Q7EW@1224|Proteobacteria,2TSMG@28211|Alphaproteobacteria,2JQ2V@204441|Rhodospirillales	204441|Rhodospirillales	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.47	ko:K00034	ko00030,ko01120,ko01200,map00030,map01120,map01200	-	R01520,R01521	RC00066	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
k59_1536953_1	1235788.C802_00727	2.2e-41	142.0	COG0756@1|root,COG0756@2|Bacteria,4NNI4@976|Bacteroidetes,2FR7A@200643|Bacteroidia,4AP3D@815|Bacteroidaceae	976|Bacteroidetes	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
k59_1536953_2	1356852.N008_00910	1.68e-27	109.0	COG0686@1|root,COG0686@2|Bacteria,4NE8F@976|Bacteroidetes,47K8G@768503|Cytophagia	976|Bacteroidetes	E	Belongs to the AlaDH PNT family	ald	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
k59_814718_1	1410608.JNKX01000008_gene1236	9.86e-10	65.1	COG1629@1|root,COG1629@2|Bacteria,4PM06@976|Bacteroidetes,2G09V@200643|Bacteroidia,4AV5C@815|Bacteroidaceae	976|Bacteroidetes	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
k59_1149361_1	926569.ANT_01460	2.54e-16	77.4	COG1159@1|root,COG1159@2|Bacteria,2G69C@200795|Chloroflexi	200795|Chloroflexi	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	-	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
k59_869700_1	1267535.KB906767_gene3835	5.64e-13	73.9	COG0577@1|root,COG0577@2|Bacteria,3Y47F@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_591789_1	1379270.AUXF01000002_gene1836	7.03e-44	161.0	COG1027@1|root,COG1027@2|Bacteria,1ZT1Y@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Fumarase C C-terminus	-	-	4.3.1.1	ko:K01744	ko00250,ko01100,map00250,map01100	-	R00490	RC00316,RC02799	ko00000,ko00001,ko01000	-	-	-	FumaraseC_C,Lyase_1,cNMP_binding
k59_1593750_1	452637.Oter_0067	2.28e-33	127.0	COG3279@1|root,COG3279@2|Bacteria,46VCX@74201|Verrucomicrobia,3KA2E@414999|Opitutae	2|Bacteria	K	PFAM response regulator receiver	-	-	-	ko:K02477	-	-	-	-	ko00000,ko02022	-	-	-	EAL,HATPase_c,HisKA,LytTR,Response_reg
k59_928722_1	211114.JOEF01000004_gene6518	4.08e-46	162.0	COG4266@1|root,COG4266@2|Bacteria,2GJ1V@201174|Actinobacteria,4DXW3@85010|Pseudonocardiales	201174|Actinobacteria	F	Belongs to the allantoicase family	alc	-	3.5.3.4	ko:K01477	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R02422	RC00379,RC00712	ko00000,ko00001,ko00002,ko01000	-	-	-	Allantoicase
k59_814735_1	1424334.W822_08910	1.89e-73	228.0	COG2159@1|root,COG2159@2|Bacteria,1MUUR@1224|Proteobacteria,2VM1S@28216|Betaproteobacteria,3T2VV@506|Alcaligenaceae	28216|Betaproteobacteria	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
k59_1039674_1	313606.M23134_04935	1.96e-38	146.0	COG1538@1|root,COG1538@2|Bacteria,4NHGK@976|Bacteroidetes	976|Bacteroidetes	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC_sub_bind,OEP
k59_1316856_1	1246484.D479_11646	1.61e-70	223.0	COG0190@1|root,COG0190@2|Bacteria,1TP1P@1239|Firmicutes,4H9Q6@91061|Bacilli,3NDAH@45667|Halobacillus	91061|Bacilli	H	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
k59_1482746_1	379066.GAU_1741	5.15e-36	125.0	COG1762@1|root,COG1762@2|Bacteria,1ZTIY@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2	-	-	-	ko:K02806	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	PTS_EIIA_2
k59_814746_1	1268622.AVS7_03160	2.1e-34	134.0	COG0399@1|root,COG0399@2|Bacteria,1MUMJ@1224|Proteobacteria,2VQRJ@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Putative transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
k59_1316866_1	504728.K649_14300	1.35e-31	119.0	COG0500@1|root,COG2226@2|Bacteria,1WIUM@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
k59_1316866_2	246194.CHY_0475	9.84e-17	79.7	COG2876@1|root,COG2876@2|Bacteria,1TP61@1239|Firmicutes,24812@186801|Clostridia,42F9V@68295|Thermoanaerobacterales	186801|Clostridia	E	PFAM DAHP synthetase I KDSA	aroF	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
k59_1706303_1	314285.KT71_06262	1.38e-19	94.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1RWT7@1236|Gammaproteobacteria,1JBPX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1646828_1	1121930.AQXG01000001_gene1526	1.16e-14	75.9	COG0737@1|root,COG2374@1|root,COG0737@2|Bacteria,COG2374@2|Bacteria	2|Bacteria	F	nucleotide catabolic process	xynX5	-	3.2.1.8	ko:K01181,ko:K07004	-	-	-	-	ko00000,ko01000	-	-	-	Endonuclease_1,Exo_endo_phos,LTD,SLH,SprB
k59_704681_1	861299.J421_1868	1.79e-12	67.8	COG3408@1|root,COG3408@2|Bacteria	2|Bacteria	G	Glycogen debranching enzyme	glgX	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N
k59_704681_2	118166.JH976537_gene4031	3.38e-34	125.0	COG0580@1|root,COG0580@2|Bacteria,1G3MJ@1117|Cyanobacteria,1H9H5@1150|Oscillatoriales	1117|Cyanobacteria	G	Major intrinsic protein	-	-	-	ko:K06188	-	-	-	-	ko00000,ko02000	1.A.8	-	-	MIP
k59_814797_1	926569.ANT_04390	3.06e-56	189.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,Sugar_tr
k59_1261740_1	1207075.PputUW4_01659	3.2e-06	53.9	COG2267@1|root,COG2267@2|Bacteria,1MZG8@1224|Proteobacteria,1RQYM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	mhpC	-	3.7.1.17	ko:K16050	ko00984,ko01100,ko01120,ko01220,map00984,map01100,map01120,map01220	-	R09883	RC02018,RC02740	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_6
k59_257991_1	1267535.KB906767_gene59	3.01e-83	257.0	COG1894@1|root,COG1894@2|Bacteria,3Y2NM@57723|Acidobacteria,2JI09@204432|Acidobacteriia	204432|Acidobacteriia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	-	-	-	-	-	-	-	-	-	-	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
k59_257991_2	1123368.AUIS01000006_gene660	2.19e-68	228.0	COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,1RMUH@1236|Gammaproteobacteria,2NBWZ@225057|Acidithiobacillales	225057|Acidithiobacillales	C	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region	-	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdop_Fe4S4,Molybdopterin,NADH-G_4Fe-4S_3
k59_146797_1	945713.IALB_1062	1.8e-56	186.0	COG0283@1|root,COG0283@2|Bacteria	2|Bacteria	F	belongs to the cytidylate kinase family. Type 1 subfamily	cmk	GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.5.1.19,2.7.4.25,6.3.2.1	ko:K00800,ko:K00945,ko:K03977,ko:K13799	ko00240,ko00400,ko00410,ko00770,ko01100,ko01110,ko01130,ko01230,map00240,map00400,map00410,map00770,map01100,map01110,map01130,map01230	M00022,M00052,M00119	R00158,R00512,R01665,R02473,R03460	RC00002,RC00096,RC00141,RC00350	ko00000,ko00001,ko00002,ko01000,ko03009	-	-	-	Cytidylate_kin,Pantoate_ligase
k59_369891_1	90371.CY43_03810	2.15e-17	84.7	COG0642@1|root,COG2205@2|Bacteria,1MUZQ@1224|Proteobacteria,1RMZT@1236|Gammaproteobacteria,3ZJ70@590|Salmonella	1236|Gammaproteobacteria	T	Domain of unknown function (DUF4118)	kdpD	GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006970,GO:0007154,GO:0007165,GO:0008134,GO:0008150,GO:0008152,GO:0009593,GO:0009605,GO:0009628,GO:0009651,GO:0009987,GO:0009991,GO:0016020,GO:0016021,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0016787,GO:0016788,GO:0016791,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0031224,GO:0031226,GO:0031668,GO:0033554,GO:0035556,GO:0036211,GO:0042221,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051606,GO:0051716,GO:0065007,GO:0071214,GO:0071470,GO:0071472,GO:0071496,GO:0071704,GO:0071944,GO:0104004,GO:0140096,GO:1901564	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,GAF_3,HATPase_c,HisKA,KdpD,Usp
k59_146803_1	661478.OP10G_0240	7.73e-32	130.0	COG1626@1|root,COG1626@2|Bacteria	2|Bacteria	G	alpha,alpha-trehalase activity	ygjK	GO:0003674,GO:0003824,GO:0004553,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0015926,GO:0016787,GO:0016798,GO:0033554,GO:0050896,GO:0051716	3.2.1.28	ko:K01194,ko:K03931	ko00500,ko01100,map00500,map01100	-	R00010	RC00049	ko00000,ko00001,ko00537,ko01000	-	GH37,GH63	-	Glyco_hydro_63,Trehalase
k59_983477_1	1229780.BN381_80302	4.26e-42	157.0	COG1674@1|root,COG1674@2|Bacteria,2GK3T@201174|Actinobacteria,3UW6P@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	D	Ftsk_gamma	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
k59_146808_1	575540.Isop_0191	9.88e-06	51.2	COG0515@1|root,COG0515@2|Bacteria,2IZFV@203682|Planctomycetes	203682|Planctomycetes	KLT	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1261770_1	1005048.CFU_0039	4.59e-80	247.0	COG1028@1|root,COG1028@2|Bacteria,1MUWC@1224|Proteobacteria,2VK5Z@28216|Betaproteobacteria,47431@75682|Oxalobacteraceae	28216|Betaproteobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
k59_1646891_1	1122915.AUGY01000021_gene6622	9.63e-07	57.0	COG1653@1|root,COG1653@2|Bacteria,1UQ5N@1239|Firmicutes,4HB2S@91061|Bacilli,26WET@186822|Paenibacillaceae	91061|Bacilli	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
k59_1316962_1	1054213.HMPREF9946_04301	5.21e-39	135.0	COG5405@1|root,COG5405@2|Bacteria,1MVF2@1224|Proteobacteria,2TRRE@28211|Alphaproteobacteria,2JR0U@204441|Rhodospirillales	204441|Rhodospirillales	O	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery	hslV	-	3.4.25.2	ko:K01419	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Proteasome
k59_1316962_2	1120972.AUMH01000011_gene226	2.08e-23	97.4	COG4974@1|root,COG4974@2|Bacteria,1TPQB@1239|Firmicutes,4HARA@91061|Bacilli,2789H@186823|Alicyclobacillaceae	91061|Bacilli	D	Belongs to the 'phage' integrase family. XerC subfamily	xerC	-	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_869833_1	290402.Cbei_0729	7.68e-10	60.8	COG1012@1|root,COG1012@2|Bacteria,1TP4S@1239|Firmicutes,247W7@186801|Clostridia,36DK7@31979|Clostridiaceae	186801|Clostridia	C	Belongs to the aldehyde dehydrogenase family	aldA	-	1.2.1.32,1.2.1.39,1.2.1.60,1.2.1.8,1.2.1.85,1.2.1.99	ko:K00130,ko:K00146,ko:K00151,ko:K09472,ko:K10217	ko00260,ko00330,ko00350,ko00360,ko00362,ko00380,ko00622,ko00643,ko01100,ko01120,ko01220,map00260,map00330,map00350,map00360,map00362,map00380,map00622,map00643,map01100,map01120,map01220	M00038,M00136,M00533,M00555,M00569	R02536,R02565,R02566,R02762,R03889,R04418,R05353,R07417,R07418	RC00080,RC00218,RC00254	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_928851_1	554065.XP_005850697.1	3.92e-17	81.3	2CV9C@1|root,2RRJX@2759|Eukaryota,381ZQ@33090|Viridiplantae	33090|Viridiplantae	S	HpcH/HpaI aldolase/citrate lyase family	-	-	-	ko:K11390	-	-	-	-	ko00000,ko01000	-	-	-	HpcH_HpaI
k59_928851_2	485913.Krac_11103	3.09e-45	155.0	COG0451@1|root,COG0451@2|Bacteria,2G9SG@200795|Chloroflexi	200795|Chloroflexi	GM	PFAM NAD-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
k59_1204023_1	944547.ABLL_0452	3.94e-74	237.0	COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,42PT5@68525|delta/epsilon subdivisions,2YNNW@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	C	NADH-quinone oxidoreductase	nuoG	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,NADH-G_4Fe-4S_3
k59_315801_1	717785.HYPMC_2369	6.32e-09	58.2	COG4520@1|root,COG4520@2|Bacteria,1N0YF@1224|Proteobacteria,2UA8D@28211|Alphaproteobacteria,3N7G9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Glycine zipper 2TM domain	omp	-	-	-	-	-	-	-	-	-	-	-	17kDa_Anti_2,Gly-zipper_Omp,Rick_17kDa_Anti
k59_1646900_1	247634.GPB2148_756	1.34e-54	186.0	COG0535@1|root,COG0535@2|Bacteria,1NEM7@1224|Proteobacteria	1224|Proteobacteria	M	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
k59_591933_1	1304883.KI912532_gene1507	4.02e-100	302.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,2VHPE@28216|Betaproteobacteria,2KUZY@206389|Rhodocyclales	206389|Rhodocyclales	U	type II secretion system protein	pilC	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
k59_146838_1	1161401.ASJA01000001_gene260	9.36e-20	90.9	COG4244@1|root,COG4244@2|Bacteria,1R2SC@1224|Proteobacteria,2UJ91@28211|Alphaproteobacteria,440SI@69657|Hyphomonadaceae	2|Bacteria	S	Predicted membrane protein (DUF2231)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2231,SnoaL_3
k59_91929_1	1385519.N801_15015	2.94e-57	191.0	COG0122@1|root,COG0122@2|Bacteria	2|Bacteria	L	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase	alkA	-	3.2.2.21	ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
k59_1204038_1	1123377.AUIV01000037_gene2143	7.43e-107	327.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria,1XDAY@135614|Xanthomonadales	135614|Xanthomonadales	V	ABC-type multidrug transport system, ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1646916_1	1268622.AVS7_02862	7.86e-23	100.0	COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,2VHY4@28216|Betaproteobacteria,4AB9A@80864|Comamonadaceae	28216|Betaproteobacteria	U	PFAM type II and III secretion system protein	pilQ	-	-	ko:K02666	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	AMIN,STN,Secretin,Secretin_N
k59_1204042_1	1123401.JHYQ01000003_gene2174	2.11e-05	52.4	COG3650@1|root,COG3650@2|Bacteria,1R2PG@1224|Proteobacteria	1224|Proteobacteria	S	Bacterial SH3 domain homologues	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_36021_1	96561.Dole_2142	9.26e-59	189.0	COG2129@1|root,COG2129@2|Bacteria,1RJJX@1224|Proteobacteria,42T2C@68525|delta/epsilon subdivisions,2WP7Q@28221|Deltaproteobacteria,2MQ17@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Metallophosphoesterase, calcineurin superfamily	-	-	-	ko:K07096	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2,Metallophos_3
k59_1261824_1	351607.Acel_0042	5.24e-37	130.0	COG1765@1|root,COG1765@2|Bacteria,2HA74@201174|Actinobacteria	201174|Actinobacteria	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
k59_1261824_2	278963.ATWD01000001_gene3959	3.15e-10	63.2	COG2318@1|root,COG2318@2|Bacteria,3Y7XR@57723|Acidobacteria,2JN1J@204432|Acidobacteriia	204432|Acidobacteriia	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
k59_646460_1	316274.Haur_4652	2.42e-14	77.8	COG1404@1|root,COG1404@2|Bacteria,2G8UU@200795|Chloroflexi,3759F@32061|Chloroflexia	32061|Chloroflexia	O	PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,CarboxypepD_reg,Peptidase_S8
k59_1039836_1	357808.RoseRS_4512	4.78e-64	206.0	COG1321@1|root,COG1918@1|root,COG1321@2|Bacteria,COG1918@2|Bacteria	2|Bacteria	P	iron ion homeostasis	feoA	-	-	ko:K03322,ko:K03709,ko:K04758	-	-	-	-	ko00000,ko02000,ko03000	2.A.55.2.6,2.A.55.3	-	-	Fe_dep_repr_C,FeoA
k59_1039836_2	357808.RoseRS_4511	4.3e-40	140.0	COG0370@1|root,COG0370@2|Bacteria,2GAJB@200795|Chloroflexi,376HM@32061|Chloroflexia	32061|Chloroflexia	P	Ferrous iron transport protein B	-	-	-	-	-	-	-	-	-	-	-	-	FeoB_N
k59_315864_1	179408.Osc7112_0973	4.22e-31	113.0	COG1396@1|root,COG1396@2|Bacteria,1G9VE@1117|Cyanobacteria,1HDBM@1150|Oscillatoriales	1117|Cyanobacteria	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_37
k59_427964_2	1150469.RSPPHO_01221	3.33e-49	159.0	COG0051@1|root,COG0051@2|Bacteria,1RGWF@1224|Proteobacteria,2U95D@28211|Alphaproteobacteria,2JST1@204441|Rhodospirillales	204441|Rhodospirillales	J	Involved in the binding of tRNA to the ribosomes	rpsJ	-	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
k59_707368_1	926561.KB900621_gene2771	4.39e-61	202.0	COG0104@1|root,COG0104@2|Bacteria,1TQ4C@1239|Firmicutes,247RN@186801|Clostridia,3WAAB@53433|Halanaerobiales	186801|Clostridia	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
k59_931425_1	243090.RB8472	2.56e-47	165.0	COG0591@1|root,COG0591@2|Bacteria,2IYAQ@203682|Planctomycetes	203682|Planctomycetes	E	Sodium:solute symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
k59_931425_2	1123487.KB892868_gene1270	2.09e-05	48.1	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,2VJ07@28216|Betaproteobacteria,2KVNA@206389|Rhodocyclales	206389|Rhodocyclales	H	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis	ubiB	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1
k59_615208_1	1205680.CAKO01000014_gene123	3.67e-16	80.5	COG1250@1|root,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2TSGF@28211|Alphaproteobacteria,2JPV5@204441|Rhodospirillales	204441|Rhodospirillales	I	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	3HCDH,3HCDH_N
k59_893401_1	504728.K649_05855	7.14e-08	61.6	COG1002@1|root,COG1002@2|Bacteria,1WIE6@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	V	N-6 DNA Methylase	-	-	-	-	-	-	-	-	-	-	-	-	Eco57I,N6_Mtase
k59_281821_1	768706.Desor_2361	4.45e-78	259.0	COG0243@1|root,COG0243@2|Bacteria,1V09X@1239|Firmicutes,24BPK@186801|Clostridia,264AS@186807|Peptococcaceae	186801|Clostridia	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.7.2.3	ko:K07812	-	-	-	-	ko00000,ko01000,ko02000	5.A.3.4	-	-	Molybdopterin,Molydop_binding
k59_615210_1	545276.KB898724_gene2063	1.12e-36	137.0	COG0529@1|root,COG2046@1|root,COG0529@2|Bacteria,COG2046@2|Bacteria,1MX0D@1224|Proteobacteria,1RNWT@1236|Gammaproteobacteria,1X2EG@135613|Chromatiales	135613|Chromatiales	P	PUA-like domain	-	-	2.7.7.4	ko:K00958	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase,ATP-sulfurylase,PUA_2
k59_114922_1	1123401.JHYQ01000013_gene680	7.75e-14	72.8	COG2197@1|root,COG2197@2|Bacteria,1N3M4@1224|Proteobacteria,1T0ZR@1236|Gammaproteobacteria,4630K@72273|Thiotrichales	72273|Thiotrichales	KT	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE
k59_948924_1	264462.Bd1596	6.73e-42	155.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2MSNC@213481|Bdellovibrionales,2WIPP@28221|Deltaproteobacteria	213481|Bdellovibrionales	NU	PFAM Type II secretion system protein E	gspE	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
k59_226147_1	234267.Acid_7161	1.41e-22	95.1	COG2159@1|root,COG2159@2|Bacteria,3Y5M2@57723|Acidobacteria	57723|Acidobacteria	E	PFAM Amidohydrolase 2	-	-	4.1.1.45	ko:K03392,ko:K07045	ko00380,ko01100,map00380,map01100	M00038	R04323	RC00779	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
k59_226147_2	861299.J421_1475	8.43e-36	134.0	COG0531@1|root,COG0531@2|Bacteria	2|Bacteria	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
k59_1115849_1	95619.PM1_0226585	8.18e-60	189.0	COG2065@1|root,COG2065@2|Bacteria,1RI6U@1224|Proteobacteria,1S6WA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	uracil phosphoribosyltransferase	pyrR	-	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000,ko03000	-	-	-	Pribosyltran
k59_1338066_1	1502851.FG93_02509	7.39e-108	332.0	COG0028@1|root,COG0028@2|Bacteria,1MX3Q@1224|Proteobacteria,2U2RW@28211|Alphaproteobacteria,3JX83@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EH	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain	-	-	2.2.1.6,4.1.1.7	ko:K01576,ko:K01652	ko00290,ko00627,ko00650,ko00660,ko00770,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00290,map00627,map00650,map00660,map00770,map01100,map01110,map01120,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R01764,R02672,R03050,R04672,R04673,R08648	RC00027,RC00106,RC00595,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_782111_1	215803.DB30_4177	0.000107	47.4	COG2133@1|root,COG2133@2|Bacteria,1Q2X7@1224|Proteobacteria,433WC@68525|delta/epsilon subdivisions,2X3UW@28221|Deltaproteobacteria,2YX6D@29|Myxococcales	28221|Deltaproteobacteria	G	pyrroloquinoline quinone binding	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1727150_1	926569.ANT_25290	5.8e-80	265.0	COG0653@1|root,COG0653@2|Bacteria,2G603@200795|Chloroflexi	200795|Chloroflexi	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_448678_1	858215.Thexy_0619	4.58e-14	78.2	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,42HU3@68295|Thermoanaerobacterales	186801|Clostridia	NT	PFAM Chemotaxis methyl-accepting receptor, signalling	mcpC3	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,dCache_1,sCache_2
k59_1227251_1	1122915.AUGY01000020_gene6476	1.93e-85	268.0	COG4638@1|root,COG4638@2|Bacteria,1UZWG@1239|Firmicutes,4HBGQ@91061|Bacilli,26VC1@186822|Paenibacillaceae	2|Bacteria	P	Rieske [2Fe-2S] domain	ligX	-	-	ko:K15060	ko00627,ko01120,map00627,map01120	-	R09275	RC00392,RC01533	ko00000,ko00001	-	-	-	Rieske
k59_3957_1	1121106.JQKB01000007_gene1070	2.13e-69	226.0	COG0620@1|root,COG0620@2|Bacteria,1MUI9@1224|Proteobacteria,2TTWK@28211|Alphaproteobacteria,2JV0E@204441|Rhodospirillales	204441|Rhodospirillales	E	Methionine synthase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1615916_1	748449.Halha_0026	6.34e-38	145.0	COG1052@1|root,COG1052@2|Bacteria,1TPCX@1239|Firmicutes,25F0C@186801|Clostridia,3WCBS@53433|Halanaerobiales	186801|Clostridia	E	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	1.1.1.26,1.1.1.310,1.1.1.399,1.1.1.95	ko:K00015,ko:K00058,ko:K16843	ko00260,ko00270,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00020	R00717,R01388,R01513,R05693	RC00031,RC00042	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
k59_782140_1	518766.Rmar_0906	7.7e-101	308.0	COG2234@1|root,COG2234@2|Bacteria,4NE66@976|Bacteroidetes	976|Bacteroidetes	J	Peptidase m28	PGCP	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
k59_1004607_1	1122997.AUDD01000005_gene1890	1.29e-06	48.9	COG0153@1|root,COG0153@2|Bacteria,2H2AH@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the GHMP kinase family	-	-	2.7.1.6	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00554,M00632	R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
k59_1004607_2	58344.JOEL01000003_gene1229	2.24e-07	57.4	COG1209@1|root,COG1209@2|Bacteria,2GP20@201174|Actinobacteria	201174|Actinobacteria	M	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
k59_1504722_1	269796.Rru_A3449	3.9e-33	123.0	COG1493@1|root,COG1493@2|Bacteria,1NNN5@1224|Proteobacteria,2UFPB@28211|Alphaproteobacteria,2JTFD@204441|Rhodospirillales	204441|Rhodospirillales	T	COG1493 Serine kinase of the HPr protein, regulates carbohydrate metabolism	hprK	-	-	ko:K06023	-	-	-	-	ko00000,ko01000	-	-	-	Hpr_kinase_C
k59_59457_1	189753.AXAS01000001_gene3616	4.06e-105	313.0	COG1073@1|root,COG1073@2|Bacteria,1MUCD@1224|Proteobacteria,2TU9V@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Acetyl xylan esterase (AXE1)	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4
k59_504270_1	529884.Rhola_00002490	9.16e-24	102.0	COG0513@1|root,COG0513@2|Bacteria,2GIUR@201174|Actinobacteria,4FMCE@85023|Microbacteriaceae	201174|Actinobacteria	L	helicase superfamily c-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	DEAD,Helicase_C
k59_3990_1	991905.SL003B_1727	1.94e-25	100.0	COG0081@1|root,COG0081@2|Bacteria,1MUE6@1224|Proteobacteria,2TRXP@28211|Alphaproteobacteria,4BPG4@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
k59_3990_2	1094558.ME5_01157	8.43e-64	197.0	COG0080@1|root,COG0080@2|Bacteria,1RA2M@1224|Proteobacteria,2U760@28211|Alphaproteobacteria,48TRS@772|Bartonellaceae	28211|Alphaproteobacteria	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
k59_226226_1	1207063.P24_06237	6.14e-40	149.0	COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,2TTBG@28211|Alphaproteobacteria,2JPA6@204441|Rhodospirillales	204441|Rhodospirillales	P	Voltage gated chloride channel	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,Voltage_CLC
k59_393011_1	644966.Tmar_1513	6.83e-92	288.0	COG1012@1|root,COG1012@2|Bacteria,1TP4S@1239|Firmicutes,247W7@186801|Clostridia,3WDC3@538999|Clostridiales incertae sedis	186801|Clostridia	C	PFAM Aldehyde dehydrogenase family	aldA	-	1.2.1.3,1.2.1.32,1.2.1.39,1.2.1.60,1.2.1.8,1.2.1.85,1.2.1.99	ko:K00128,ko:K00130,ko:K00146,ko:K00151,ko:K09472,ko:K10217	ko00010,ko00053,ko00071,ko00260,ko00280,ko00310,ko00330,ko00340,ko00350,ko00360,ko00362,ko00380,ko00410,ko00561,ko00620,ko00622,ko00625,ko00643,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00053,map00071,map00260,map00280,map00310,map00330,map00340,map00350,map00360,map00362,map00380,map00410,map00561,map00620,map00622,map00625,map00643,map00903,map00981,map01100,map01110,map01120,map01130,map01220	M00038,M00135,M00136,M00533,M00555,M00569	R00264,R00631,R00710,R00904,R01752,R01986,R02536,R02549,R02565,R02566,R02678,R02762,R02940,R02957,R03283,R03869,R03889,R04065,R04418,R04506,R04903,R05050,R05237,R05238,R05286,R05353,R06366,R07417,R07418,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00254,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_1115930_1	1189619.pgond44_02298	1.27e-15	77.0	COG3547@1|root,COG3547@2|Bacteria,4NF2F@976|Bacteroidetes,1HXCM@117743|Flavobacteriia,4C2NG@83612|Psychroflexus	976|Bacteroidetes	L	COG3547 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1282545_1	861299.J421_3981	2.53e-43	152.0	COG4972@1|root,COG4972@2|Bacteria,1ZSYA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	NU	Type IV pilus assembly protein PilM;	-	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
k59_504288_1	570952.ATVH01000017_gene1699	4.65e-10	60.1	COG0174@1|root,COG0174@2|Bacteria,1MXPK@1224|Proteobacteria,2TUHR@28211|Alphaproteobacteria,2JPM1@204441|Rhodospirillales	204441|Rhodospirillales	E	Glutamine synthetase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Gln-synt_C,Gln-synt_N_2
k59_504288_2	420324.KI911965_gene832	1.43e-32	127.0	COG4178@1|root,COG4178@2|Bacteria,1MW09@1224|Proteobacteria,2TS9Q@28211|Alphaproteobacteria,1JQWF@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	PFAM ABC transporter	-	-	-	ko:K02471	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1.203.11,3.A.1.203.4	-	-	ABC_membrane_2,ABC_tran
k59_1449474_1	69279.BG36_12550	2.71e-13	77.4	COG0348@1|root,COG0348@2|Bacteria,1R9JQ@1224|Proteobacteria,2U3WR@28211|Alphaproteobacteria,43H6R@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_559607_1	713586.KB900536_gene2659	3.12e-93	287.0	COG2801@1|root,COG2801@2|Bacteria,1N207@1224|Proteobacteria,1S1FB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_28,HTH_32,LZ_Tnp_IS481,rve,rve_3
k59_949034_1	796942.HMPREF9623_01032	3.86e-14	75.9	COG1040@1|root,COG1040@2|Bacteria,1VF2G@1239|Firmicutes,24IG6@186801|Clostridia	186801|Clostridia	S	ComF family	comF	-	-	ko:K02242	-	M00429	-	-	ko00000,ko00002,ko02044	-	-	-	Pribosyltran
k59_281941_1	59196.RICGR_1132	4.78e-37	134.0	COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,1RQ72@1236|Gammaproteobacteria,1JCUB@118969|Legionellales	118969|Legionellales	M	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis	lpxC	-	3.5.1.108	ko:K02535	ko00540,ko01100,map00540,map01100	M00060	R04587	RC00166,RC00300	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxC
k59_59492_1	272134.KB731324_gene6649	7.28e-83	268.0	COG1554@1|root,COG1554@2|Bacteria,1G0DN@1117|Cyanobacteria,1HA78@1150|Oscillatoriales	1117|Cyanobacteria	G	Glycosyl hydrolase family 65 central catalytic domain	-	-	2.4.1.64	ko:K05342	ko00500,ko01100,map00500,map01100	-	R02727	RC00049	ko00000,ko00001,ko01000	-	GH65	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m
k59_837669_1	1380391.JIAS01000011_gene4715	1.16e-19	82.8	COG5572@1|root,COG5572@2|Bacteria	2|Bacteria	S	Predicted integral membrane protein (DUF2282)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2282
k59_4025_1	1129374.AJE_15564	1.21e-42	157.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MUJ3@1224|Proteobacteria,1RRN4@1236|Gammaproteobacteria,4674P@72275|Alteromonadaceae	1236|Gammaproteobacteria	EU	Prolyl oligopeptidase, N-terminal beta-propeller domain	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9,Peptidase_S9_N
k59_1560460_1	379066.GAU_3468	6.77e-34	122.0	COG3832@1|root,COG3832@2|Bacteria	2|Bacteria	J	glyoxalase III activity	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	AHSA1
k59_1560460_2	1535287.JP74_08015	2.41e-23	92.4	COG0640@1|root,COG0640@2|Bacteria,1RH5P@1224|Proteobacteria,2U960@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	transcriptional regulator, ArsR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
k59_559630_1	319003.Bra1253DRAFT_00193	1.15e-40	139.0	COG1917@1|root,COG1917@2|Bacteria,1RGZB@1224|Proteobacteria,2U5EF@28211|Alphaproteobacteria,3JYKP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_671105_1	335543.Sfum_3028	8.76e-40	144.0	COG1183@1|root,COG1183@2|Bacteria,1MWD9@1224|Proteobacteria,42QV4@68525|delta/epsilon subdivisions,2WMR6@28221|Deltaproteobacteria,2MQE6@213462|Syntrophobacterales	28221|Deltaproteobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pssA	-	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_transf
k59_782211_2	1007105.PT7_2633	8.74e-32	117.0	arCOG10157@1|root,3220G@2|Bacteria,1NPKZ@1224|Proteobacteria,2VYBF@28216|Betaproteobacteria,3T53D@506|Alcaligenaceae	28216|Betaproteobacteria	S	Methylmuconolactone methyl-isomerase	-	-	-	-	-	-	-	-	-	-	-	-	EthD
k59_337272_1	290315.Clim_2321	2.02e-05	51.6	COG0842@1|root,COG0842@2|Bacteria,1FEI2@1090|Chlorobi	1090|Chlorobi	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
k59_4052_1	909663.KI867150_gene61	2.27e-29	117.0	COG0620@1|root,COG0620@2|Bacteria,1R6KI@1224|Proteobacteria,42PCN@68525|delta/epsilon subdivisions,2WKT3@28221|Deltaproteobacteria,2MRRP@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_671111_1	936455.KI421499_gene7677	5.78e-34	132.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,3JR8W@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,TPR_2,Trans_reg_C
k59_1671754_1	269799.Gmet_2820	1.2e-79	257.0	COG1657@1|root,COG1657@2|Bacteria,1MUIP@1224|Proteobacteria,42Q4W@68525|delta/epsilon subdivisions,2WJ9H@28221|Deltaproteobacteria,43UJ3@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	Squalene-hopene cyclase C-terminal domain	shc-1	-	4.2.1.129,5.4.99.17,5.4.99.7	ko:K01852,ko:K06045	ko00100,ko00909,ko01100,ko01110,ko01130,map00100,map00909,map01100,map01110,map01130	M00101	R03199,R07322,R07323	RC00874,RC01850,RC01851	ko00000,ko00001,ko00002,ko01000	-	-	-	SQHop_cyclase_C,SQHop_cyclase_N
k59_1004687_1	1206741.BAFX01000003_gene5447	5.22e-06	51.6	COG4585@1|root,COG4585@2|Bacteria,2GMMU@201174|Actinobacteria,4G8KJ@85025|Nocardiaceae	201174|Actinobacteria	T	Putative sensor	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,Sensor
k59_4062_1	1408437.JNJN01000001_gene1678	1.74e-20	92.0	COG0550@1|root,COG0550@2|Bacteria,1TPUS@1239|Firmicutes,248MG@186801|Clostridia,25V5P@186806|Eubacteriaceae	186801|Clostridia	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
k59_726789_1	489825.LYNGBM3L_75220	4.28e-62	204.0	2DG8R@1|root,2ZUYV@2|Bacteria,1G8JI@1117|Cyanobacteria,1HC9E@1150|Oscillatoriales	1117|Cyanobacteria	H	Sulfotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_1
k59_115074_1	640081.Dsui_3268	2.63e-61	204.0	COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,2VJIC@28216|Betaproteobacteria,2KU79@206389|Rhodocyclales	206389|Rhodocyclales	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
k59_671134_1	1443665.JACA01000003_gene613	2.04e-18	88.2	COG0596@1|root,COG0596@2|Bacteria,4NQYB@976|Bacteroidetes,1I318@117743|Flavobacteriia,2YK2Q@290174|Aquimarina	976|Bacteroidetes	S	TAP-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
k59_1393603_1	1122226.AUHX01000006_gene2120	6.65e-09	62.4	COG4099@1|root,COG4099@2|Bacteria,4NFSH@976|Bacteroidetes,1HY30@117743|Flavobacteriia	976|Bacteroidetes	E	Phospholipase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_2,Esterase_phd,Peptidase_S9
k59_559663_1	225937.HP15_440	1.09e-39	145.0	COG0438@1|root,COG0438@2|Bacteria,1PDW1@1224|Proteobacteria,1RZIK@1236|Gammaproteobacteria,469U7@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
k59_893589_1	574966.KB898652_gene1689	1.52e-50	172.0	COG0697@1|root,COG0697@2|Bacteria,1R7CG@1224|Proteobacteria,1S0XU@1236|Gammaproteobacteria,1XJ96@135619|Oceanospirillales	135619|Oceanospirillales	EG	of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_726817_1	56107.Cylst_0306	3.09e-18	85.9	2B0GJ@1|root,31SU3@2|Bacteria,1G4WP@1117|Cyanobacteria,1HPIU@1161|Nostocales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_782260_1	37919.EP51_25250	8.05e-26	104.0	COG1082@1|root,COG1082@2|Bacteria,2GK1S@201174|Actinobacteria,4G4P8@85025|Nocardiaceae	201174|Actinobacteria	G	AP endonuclease family 2 C terminus	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
k59_782260_2	1460634.JCM19037_3995	1.25e-38	139.0	COG1082@1|root,COG1082@2|Bacteria,1TPJT@1239|Firmicutes,4H9KJ@91061|Bacilli	91061|Bacilli	G	Xylose isomerase	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
k59_4099_1	1379270.AUXF01000003_gene3394	1.21e-75	238.0	COG4972@1|root,COG4972@2|Bacteria,1ZSYA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	NU	Type IV pilus assembly protein PilM;	-	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
k59_893599_1	1178482.BJB45_18855	0.000212	48.5	COG0845@1|root,COG0845@2|Bacteria,1R99C@1224|Proteobacteria,1RZS0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3
k59_1393621_1	1117315.AHCA01000004_gene678	2.44e-06	55.8	COG4772@1|root,COG4772@2|Bacteria,1MUIH@1224|Proteobacteria,1RQYX@1236|Gammaproteobacteria,2PZVE@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	P	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k59_1504840_1	1121939.L861_17285	2.41e-84	263.0	COG0277@1|root,COG0277@2|Bacteria,1MUPW@1224|Proteobacteria,1RRDD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	FAD linked oxidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
k59_4105_2	927677.ALVU02000001_gene1806	1.76e-59	190.0	COG5485@1|root,COG5485@2|Bacteria,1GCKP@1117|Cyanobacteria	1117|Cyanobacteria	S	Ester cyclase	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	SnoaL
k59_1282647_1	387631.Asulf_00175	5.59e-38	134.0	COG2057@1|root,arCOG05316@2157|Archaea,2XW2C@28890|Euryarchaeota,246AI@183980|Archaeoglobi	183980|Archaeoglobi	I	Coenzyme A transferase	-	-	2.8.3.12	ko:K01040	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
k59_1282647_2	387631.Asulf_00176	3.79e-32	121.0	COG1788@1|root,arCOG01987@2157|Archaea,2XVRA@28890|Euryarchaeota,246WP@183980|Archaeoglobi	183980|Archaeoglobi	I	Coenzyme A transferase	-	-	2.8.3.12	ko:K01039	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
k59_949116_1	1167006.UWK_00989	8.3e-28	109.0	COG2823@1|root,COG2823@2|Bacteria,1NB3W@1224|Proteobacteria,42T8P@68525|delta/epsilon subdivisions,2WR4I@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM transport-associated	-	-	-	ko:K04065	-	-	-	-	ko00000	-	-	-	BON
k59_949116_2	443143.GM18_1678	2.57e-32	115.0	COG2823@1|root,COG2823@2|Bacteria,1N0SU@1224|Proteobacteria,42VD3@68525|delta/epsilon subdivisions,2WRQJ@28221|Deltaproteobacteria,43VE0@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	BON domain	-	-	-	-	-	-	-	-	-	-	-	-	BON
k59_505837_1	1163408.UU9_10262	1.03e-16	78.2	COG1062@1|root,COG1062@2|Bacteria,1MUK4@1224|Proteobacteria,1RNQ4@1236|Gammaproteobacteria,1X3UT@135614|Xanthomonadales	135614|Xanthomonadales	C	Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily	adhC	-	1.1.1.1,1.1.1.284	ko:K00121	ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_505837_2	679199.HMPREF9332_01373	4.25e-13	70.9	COG0454@1|root,COG0801@1|root,COG0456@2|Bacteria,COG0801@2|Bacteria,4NGE8@976|Bacteroidetes,2FSKM@200643|Bacteroidia,1WDHN@1283313|Alloprevotella	976|Bacteroidetes	HK	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)	folK	-	2.7.6.3	ko:K00950	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HPPK,dNK
k59_783688_1	497964.CfE428DRAFT_0631	8.4e-32	128.0	COG2114@1|root,COG3903@1|root,COG2114@2|Bacteria,COG3903@2|Bacteria,46TZ3@74201|Verrucomicrobia	74201|Verrucomicrobia	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,NB-ARC
k59_1339687_1	1333998.M2A_0299	3.13e-47	155.0	COG0735@1|root,COG0735@2|Bacteria,1RDWJ@1224|Proteobacteria,2U6ZS@28211|Alphaproteobacteria,4BQAG@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	K	Belongs to the Fur family	fur	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
k59_1339687_2	414684.RC1_2607	8.3e-14	71.6	COG3176@1|root,COG3176@2|Bacteria,1MWIM@1224|Proteobacteria,2TUVA@28211|Alphaproteobacteria,2JPVT@204441|Rhodospirillales	204441|Rhodospirillales	S	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_5
k59_1673252_1	1121085.AUCI01000008_gene636	3.3e-32	127.0	COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,1TP3N@1239|Firmicutes,4HBQ6@91061|Bacilli,1ZCWU@1386|Bacillus	91061|Bacilli	J	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA	sun	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N,NusB
k59_950596_1	1123052.AUDF01000010_gene1308	4.84e-05	50.8	COG0747@1|root,COG0747@2|Bacteria,2GJ4B@201174|Actinobacteria,4FKFM@85023|Microbacteriaceae	201174|Actinobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_616844_1	492774.JQMB01000016_gene1645	4.41e-24	107.0	COG4618@1|root,COG4618@2|Bacteria,1NTI5@1224|Proteobacteria,2TR17@28211|Alphaproteobacteria,4B9EG@82115|Rhizobiaceae	28211|Alphaproteobacteria	V	ABC-type protease lipase transport system, ATPase and permease components	-	GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0016020,GO:0044464,GO:0046903,GO:0051179,GO:0051234,GO:0071944	-	ko:K06148	-	-	-	-	ko00000,ko02000	3.A.1	-	-	ABC_membrane,ABC_tran
k59_1451084_1	670292.JH26_02420	0.000313	48.9	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Adenylate cyclase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,TPR_2,TPR_8
k59_180959_1	1111732.AZOD01000023_gene1880	1.2e-41	143.0	COG0723@1|root,COG0723@2|Bacteria,1RAA2@1224|Proteobacteria,1RP9H@1236|Gammaproteobacteria,1X4TD@135614|Xanthomonadales	135614|Xanthomonadales	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	petA	-	1.10.2.2	ko:K00411	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske,UCR_Fe-S_N
k59_180959_2	546268.NEISUBOT_03143	6.29e-24	100.0	COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,2VHP5@28216|Betaproteobacteria,2KQHP@206351|Neisseriales	206351|Neisseriales	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	petB	-	-	ko:K00412	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko03029	-	-	-	Cytochrom_B_C,Cytochrome_B
k59_1515505_1	1223542.GM1_011_00410	2.92e-07	57.4	COG3629@1|root,COG3899@1|root,COG3629@2|Bacteria,COG3899@2|Bacteria,2I2U4@201174|Actinobacteria,4GB84@85026|Gordoniaceae	201174|Actinobacteria	K	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,Trans_reg_C
k59_1238886_1	661478.OP10G_2431	7.63e-22	99.8	COG1228@1|root,COG1228@2|Bacteria	2|Bacteria	Q	imidazolonepropionase activity	-	-	3.5.1.25	ko:K01443	ko00520,ko01130,map00520,map01130	-	R02059	RC00166,RC00300	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
k59_1238888_1	526227.Mesil_1914	1.43e-23	101.0	COG0675@1|root,COG0675@2|Bacteria,1WJPZ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	L	SPTR C1XTD3 Transposase, IS605 OrfB family, central region	-	-	-	ko:K07496	-	-	-	-	ko00000	-	-	-	HTH_OrfB_IS605,OrfB_IS605,OrfB_Zn_ribbon
k59_847874_1	1033802.SSPSH_001269	1.82e-45	156.0	COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,1S46A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
k59_237161_2	1121413.JMKT01000010_gene852	2.3e-40	137.0	COG0824@1|root,COG0824@2|Bacteria,1RI3X@1224|Proteobacteria,42SW5@68525|delta/epsilon subdivisions,2WW97@28221|Deltaproteobacteria,2MBHH@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Acyl-ACP thioesterase	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	Acyl-ACP_TE
k59_737622_1	95619.PM1_0205055	6.11e-33	131.0	COG0784@1|root,COG4251@1|root,COG0784@2|Bacteria,COG4251@2|Bacteria,1NC9X@1224|Proteobacteria,1SVEC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Histidine kinase	-	-	-	ko:K20971	ko02025,map02025	-	-	-	ko00000,ko00001,ko01001,ko02022	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,HATPase_c,HisKA,Response_reg
k59_1515534_1	1380391.JIAS01000018_gene1084	4.59e-20	87.8	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2TSA7@28211|Alphaproteobacteria,2JVG4@204441|Rhodospirillales	204441|Rhodospirillales	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6
k59_1127105_1	926569.ANT_11050	5.52e-117	347.0	COG0766@1|root,COG0766@2|Bacteria,2G666@200795|Chloroflexi	200795|Chloroflexi	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
k59_959597_1	1231241.Mc24_07073	6.59e-40	145.0	COG2873@1|root,COG2873@2|Bacteria,2GC2R@200918|Thermotogae	200918|Thermotogae	E	TIGRFAM O-acetylhomoserine O-acetylserine sulfhydrylase	-	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
k59_1015677_1	868595.Desca_1044	7.1e-18	82.0	COG2215@1|root,COG2215@2|Bacteria,1VA77@1239|Firmicutes	1239|Firmicutes	S	PFAM Nickel cobalt transporter, high-affinity	ureH	-	-	-	-	-	-	-	-	-	-	-	DsbD_2
k59_237184_1	225400.XP_006765717.1	1.41e-16	84.0	COG1249@1|root,KOG0405@2759|Eukaryota,39J8D@33154|Opisthokonta,3BDB0@33208|Metazoa,3D06N@33213|Bilateria,482J2@7711|Chordata,48UWV@7742|Vertebrata,3J217@40674|Mammalia,4KP6P@9397|Chiroptera	33208|Metazoa	Q	Glutathione reductase	GSR	GO:0000003,GO:0000166,GO:0000302,GO:0000303,GO:0000305,GO:0002931,GO:0003674,GO:0003824,GO:0004362,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0005886,GO:0006091,GO:0006139,GO:0006518,GO:0006575,GO:0006725,GO:0006749,GO:0006790,GO:0006807,GO:0006950,GO:0006979,GO:0007276,GO:0007283,GO:0007568,GO:0007584,GO:0008150,GO:0008152,GO:0009055,GO:0009605,GO:0009636,GO:0009897,GO:0009986,GO:0009987,GO:0009991,GO:0010033,GO:0010035,GO:0010038,GO:0010039,GO:0010041,GO:0014823,GO:0015036,GO:0015037,GO:0015038,GO:0015949,GO:0016020,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0018996,GO:0019953,GO:0022404,GO:0022414,GO:0022900,GO:0031667,GO:0031974,GO:0032501,GO:0032502,GO:0032504,GO:0033189,GO:0033218,GO:0033273,GO:0033554,GO:0033993,GO:0034599,GO:0034641,GO:0035094,GO:0036094,GO:0042221,GO:0042277,GO:0042303,GO:0042395,GO:0042493,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043295,GO:0043603,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044459,GO:0044464,GO:0044703,GO:0045471,GO:0046483,GO:0046677,GO:0046686,GO:0046983,GO:0048037,GO:0048232,GO:0048609,GO:0050660,GO:0050661,GO:0050662,GO:0050896,GO:0051186,GO:0051704,GO:0051716,GO:0055086,GO:0055114,GO:0070013,GO:0070887,GO:0071704,GO:0071944,GO:0072341,GO:0097159,GO:0097237,GO:0097305,GO:0098552,GO:0098622,GO:0098754,GO:0098869,GO:1900750,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901681,GO:1901700,GO:1990748	1.8.1.7	ko:K00383	ko00480,ko04918,map00480,map04918	-	R00094,R00115	RC00011	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_1737853_1	1333998.M2A_1792	8.52e-101	306.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2TU0K@28211|Alphaproteobacteria,4BPW3@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	merA	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_1460362_1	671143.DAMO_1057	2.07e-58	204.0	COG1391@1|root,COG1391@2|Bacteria	2|Bacteria	H	[glutamate-ammonia-ligase] adenylyltransferase activity	glnE	GO:0000166,GO:0000287,GO:0000820,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006521,GO:0006541,GO:0006542,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0008882,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0010565,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0019222,GO:0019752,GO:0030554,GO:0031323,GO:0032553,GO:0032555,GO:0032559,GO:0033238,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0070566,GO:0071704,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
k59_1682305_1	1347086.CCBA010000003_gene3962	1.38e-23	102.0	COG0324@1|root,COG0324@2|Bacteria,1TPSC@1239|Firmicutes,4HAVW@91061|Bacilli,1ZBX9@1386|Bacillus	91061|Bacilli	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
k59_70027_1	1121378.KB899716_gene485	4.55e-33	127.0	COG0715@1|root,COG0715@2|Bacteria,1WMBN@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	NMT1/THI5 like	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
k59_1348692_1	926569.ANT_30070	1.53e-25	101.0	COG0357@1|root,COG0357@2|Bacteria,2G6HF@200795|Chloroflexi	200795|Chloroflexi	J	Specifically methylates the N7 position of a guanine in 16S rRNA	rsmG	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
k59_1348692_2	880073.Calab_0294	2.53e-41	139.0	COG1917@1|root,COG1917@2|Bacteria,2NQ91@2323|unclassified Bacteria	2|Bacteria	S	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_125162_1	1120953.AUBH01000017_gene2892	1.17e-05	46.6	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,1RP81@1236|Gammaproteobacteria,4657S@72275|Alteromonadaceae	1236|Gammaproteobacteria	F	Catalyzes the synthesis of GMP from XMP	guaA	GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	iJN746.PP_1032,iSF_1195.SF2553,iSFxv_1172.SFxv_2808,iS_1188.S2725,iYL1228.KPN_02833	GATase,GMP_synt_C,NAD_synthase
k59_125162_2	1379270.AUXF01000006_gene141	3.81e-102	313.0	COG0442@1|root,COG0442@2|Bacteria,1ZT48@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
k59_1404541_1	1238182.C882_1234	5.62e-99	306.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,2TU21@28211|Alphaproteobacteria,2JSY5@204441|Rhodospirillales	204441|Rhodospirillales	C	Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR,POR_N
k59_1127144_1	1254432.SCE1572_12180	3.47e-30	122.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42MK5@68525|delta/epsilon subdivisions,2WJ3Z@28221|Deltaproteobacteria,2YZPZ@29|Myxococcales	28221|Deltaproteobacteria	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_847940_1	263820.PTO0118	5.66e-34	127.0	COG1335@1|root,arCOG01943@2157|Archaea,2Y1IW@28890|Euryarchaeota,2427T@183967|Thermoplasmata	183967|Thermoplasmata	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
k59_904746_1	1268239.PALB_12380	6.45e-08	58.2	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,2PZWM@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	M	Belongs to the peptidase S1C family	degQ	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0006508,GO:0006515,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009897,GO:0009986,GO:0009987,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019538,GO:0030163,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031233,GO:0031975,GO:0042597,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051603,GO:0061077,GO:0070011,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0140096,GO:1901564,GO:1901565,GO:1901575	1.3.1.74,3.4.21.107	ko:K04771,ko:K04772,ko:K08070	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ,PDZ_2,Trypsin_2
k59_625692_1	1410676.JNKL01000014_gene1920	4.95e-60	193.0	COG1347@1|root,COG1347@2|Bacteria,1MUZR@1224|Proteobacteria,1RNFE@1236|Gammaproteobacteria,1Y3FG@135624|Aeromonadales	135624|Aeromonadales	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrD	-	1.6.5.8	ko:K00349	-	-	-	-	ko00000,ko01000	-	-	-	Rnf-Nqr
k59_1515597_1	237368.SCABRO_03411	1.46e-41	145.0	COG2003@1|root,COG2003@2|Bacteria,2J06Y@203682|Planctomycetes	203682|Planctomycetes	E	RadC-like JAB domain	-	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
k59_1515597_2	1121440.AUMA01000008_gene953	0.000148	44.3	COG1914@1|root,COG1914@2|Bacteria,1MW6X@1224|Proteobacteria,42RRV@68525|delta/epsilon subdivisions,2WNKH@28221|Deltaproteobacteria,2MH39@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Natural resistance-associated macrophage protein	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
k59_904757_1	1499967.BAYZ01000028_gene1307	6.53e-84	261.0	COG4177@1|root,COG4177@2|Bacteria,2NPMP@2323|unclassified Bacteria	2|Bacteria	U	Branched-chain amino acid transport system / permease component	livM	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_459972_1	1177594.MIC448_460014	1.05e-17	81.6	COG3832@1|root,COG3832@2|Bacteria	2|Bacteria	J	glyoxalase III activity	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
k59_1571257_1	1229780.BN381_100074	3.8e-90	276.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,3UW6J@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
k59_1737912_1	1261545.MBE-HAL_2568	6.27e-11	65.1	COG0392@1|root,arCOG00897@2157|Archaea,2XT65@28890|Euryarchaeota,23T0C@183963|Halobacteria	183963|Halobacteria	M	COG0463 Glycosyltransferases involved in cell wall biogenesis	dpg	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	Glycos_transf_2,LPG_synthase_TM
k59_125194_1	523791.Kkor_2182	6.03e-17	81.6	COG0726@1|root,COG0726@2|Bacteria,1RFCG@1224|Proteobacteria,1S808@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
k59_125194_2	204669.Acid345_3040	1.01e-14	73.9	COG3653@1|root,COG3653@2|Bacteria,3Y3Q2@57723|Acidobacteria,2JJ0K@204432|Acidobacteriia	204432|Acidobacteriia	Q	Amidohydrolase family	-	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
k59_292780_1	1479623.JHEL01000015_gene302	1.32e-20	89.4	COG0472@1|root,COG0472@2|Bacteria,2GNEH@201174|Actinobacteria,4FM5T@85023|Microbacteriaceae	201174|Actinobacteria	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	GO:0008150,GO:0040007	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
k59_292780_2	309807.SRU_0558	3.33e-24	105.0	COG0771@1|root,COG0771@2|Bacteria,4NEFF@976|Bacteroidetes,1FITH@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
k59_14810_1	754476.Q7A_2896	4.87e-09	58.9	COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,1RM8G@1236|Gammaproteobacteria,46031@72273|Thiotrichales	72273|Thiotrichales	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
k59_14810_2	218284.CCDN010000009_gene4274	2.92e-30	118.0	COG1624@1|root,COG1624@2|Bacteria,1TPRW@1239|Firmicutes,4H9XZ@91061|Bacilli,1ZBIU@1386|Bacillus	91061|Bacilli	S	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria	dacA	GO:0003674,GO:0003824,GO:0004016,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0009975,GO:0016020,GO:0016021,GO:0016829,GO:0016849,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	2.7.7.85	ko:K18672	-	-	-	-	ko00000,ko01000	-	-	-	DisA_N
k59_1737923_1	1411123.JQNH01000001_gene2578	1.17e-55	186.0	COG0392@1|root,COG0392@2|Bacteria,1MXH9@1224|Proteobacteria,2U1DX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
k59_682429_2	1121440.AUMA01000008_gene1000	2.17e-16	83.2	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,42MW3@68525|delta/epsilon subdivisions,2WIXV@28221|Deltaproteobacteria,2M800@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	PFAM Pyruvate phosphate dikinase, PEP	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
k59_515087_1	682795.AciX8_0056	1.4e-70	223.0	COG0777@1|root,COG0777@2|Bacteria,3Y2U9@57723|Acidobacteria,2JI81@204432|Acidobacteriia	204432|Acidobacteriia	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	-	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_959688_1	545264.KB898752_gene2347	1.75e-83	264.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1MU9U@1224|Proteobacteria,1RNKA@1236|Gammaproteobacteria,1WWS1@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.5.1	ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
k59_403804_2	882082.SaccyDRAFT_3811	3.8e-41	149.0	COG4626@1|root,COG4626@2|Bacteria,2IB7D@201174|Actinobacteria,4E8SB@85010|Pseudonocardiales	201174|Actinobacteria	S	Terminase	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_1
k59_125220_1	1267535.KB906767_gene4998	9.83e-23	102.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_1571292_1	1287276.X752_27350	2.44e-54	184.0	COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,2TRWG@28211|Alphaproteobacteria,43I37@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	-	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C
k59_1239025_1	29486.NJ56_02720	1.57e-47	162.0	COG3717@1|root,COG3717@2|Bacteria,1MU9D@1224|Proteobacteria,1RPDB@1236|Gammaproteobacteria,41E38@629|Yersinia	1236|Gammaproteobacteria	G	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate	kduI	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005975,GO:0005996,GO:0006063,GO:0006064,GO:0006082,GO:0008150,GO:0008152,GO:0008697,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016853,GO:0016860,GO:0016861,GO:0019585,GO:0019586,GO:0019698,GO:0019752,GO:0032787,GO:0042802,GO:0042839,GO:0042840,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046365,GO:0046395,GO:0046396,GO:0046397,GO:0046872,GO:0071704,GO:0072329,GO:1901575	5.3.1.17	ko:K01815	ko00040,map00040	-	R04383	RC00541	ko00000,ko00001,ko01000	-	-	-	KduI
k59_904799_2	37919.EP51_26835	2.36e-19	84.7	COG1024@1|root,COG1024@2|Bacteria,2GJ1A@201174|Actinobacteria,4G8SW@85025|Nocardiaceae	201174|Actinobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
k59_1348779_1	883096.HMPREF9699_00528	6.1e-31	120.0	COG3293@1|root,COG3293@2|Bacteria,4NM10@976|Bacteroidetes,1I0ZW@117743|Flavobacteriia	976|Bacteroidetes	L	PFAM Transposase, IS4-like	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DDE_Tnp_4,DUF4096
k59_1293105_1	1116472.MGMO_96c00130	4.04e-09	58.5	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1XEV2@135618|Methylococcales	135618|Methylococcales	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k59_1293105_2	1089552.KI911559_gene169	7.33e-29	111.0	COG2353@1|root,COG2353@2|Bacteria,1RJFZ@1224|Proteobacteria,2UBXA@28211|Alphaproteobacteria,2JTIZ@204441|Rhodospirillales	204441|Rhodospirillales	S	YceI-like domain	-	-	-	-	-	-	-	-	-	-	-	-	YceI
k59_1571321_1	388051.AUFE01000070_gene3819	2.33e-27	115.0	COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2VKH1@28216|Betaproteobacteria,1JZT2@119060|Burkholderiaceae	28216|Betaproteobacteria	T	adenylyl cyclase class-3 4 guanylyl cyclase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DZR,Guanylate_cyc
k59_1737975_1	926569.ANT_20670	1.38e-35	135.0	COG2064@1|root,COG2064@2|Bacteria,2G6CF@200795|Chloroflexi	200795|Chloroflexi	NU	PFAM type II secretion system protein	-	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
k59_737763_1	926569.ANT_03090	1.27e-51	174.0	COG1575@1|root,COG1575@2|Bacteria	2|Bacteria	H	Belongs to the MenA family. Type 1 subfamily	menA	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
k59_959739_1	497321.C664_06953	1.62e-50	171.0	COG3026@1|root,COG3026@2|Bacteria,1MUQ8@1224|Proteobacteria,2VMZQ@28216|Betaproteobacteria,2KUKH@206389|Rhodocyclales	206389|Rhodocyclales	T	Sigma E regulatory protein, MucB RseB	rseB	-	-	ko:K03598	-	-	-	-	ko00000,ko03021	-	-	-	MucB_RseB,MucB_RseB_C
k59_515147_1	946483.Cenrod_0414	1.83e-51	176.0	COG0493@1|root,COG1144@1|root,COG0493@2|Bacteria,COG1144@2|Bacteria,1MU2H@1224|Proteobacteria,2VM9R@28216|Betaproteobacteria,4AD4V@80864|Comamonadaceae	28216|Betaproteobacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Pyr_redox_2,Pyr_redox_3
k59_515147_2	1255043.TVNIR_3268	2.3e-25	105.0	COG0281@1|root,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,1RQ11@1236|Gammaproteobacteria,1WX9G@135613|Chromatiales	135613|Chromatiales	C	PFAM Malic enzyme, NAD binding domain	-	-	1.1.1.40	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00169,M00172	R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,malic
k59_1348812_1	765914.ThisiDRAFT_0962	1.08e-75	254.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,1RP0K@1236|Gammaproteobacteria,1WVZ3@135613|Chromatiales	135613|Chromatiales	L	DNA polymerase III alpha subunit	-	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,Intein_splicing,LAGLIDADG_3,PHP,tRNA_anti-codon
k59_1127264_1	525904.Tter_0922	2.13e-12	66.6	COG2120@1|root,COG2120@2|Bacteria,2NPAV@2323|unclassified Bacteria	2|Bacteria	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
k59_1127264_2	926569.ANT_18190	3.83e-28	112.0	COG1774@1|root,COG1774@2|Bacteria,2G6AJ@200795|Chloroflexi	200795|Chloroflexi	NU	PFAM PSP1 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PSP1
k59_1406805_1	1123288.SOV_7c00350	1.41e-59	193.0	COG0321@1|root,COG0321@2|Bacteria,1V44P@1239|Firmicutes,4H7EU@909932|Negativicutes	909932|Negativicutes	H	Biotin/lipoate A/B protein ligase family	-	-	-	-	-	-	-	-	-	-	-	-	BPL_LplA_LipB
k59_517395_1	1123487.KB892841_gene4306	1.74e-48	172.0	COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,2VHBJ@28216|Betaproteobacteria,2KUXR@206389|Rhodocyclales	206389|Rhodocyclales	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
k59_517395_2	265072.Mfla_1625	9.9e-13	67.8	COG0566@1|root,COG0566@2|Bacteria,1MWCM@1224|Proteobacteria,2VHF4@28216|Betaproteobacteria,2KKG5@206350|Nitrosomonadales	206350|Nitrosomonadales	J	Specifically methylates the ribose of guanosine 2251 in 23S rRNA	rlmB	-	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
k59_795433_1	926569.ANT_11200	1.65e-19	89.0	COG2843@1|root,COG2843@2|Bacteria,2G78I@200795|Chloroflexi	200795|Chloroflexi	M	Bacterial capsule synthesis protein PGA_cap	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
k59_795433_2	313612.L8106_13405	1.59e-11	63.2	COG1878@1|root,COG1878@2|Bacteria,1G60Q@1117|Cyanobacteria,1HHEV@1150|Oscillatoriales	1117|Cyanobacteria	S	Putative cyclase	-	-	3.5.1.9	ko:K07130	ko00380,ko00630,ko01100,map00380,map00630,map01100	M00038	R00988,R01959,R04911	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Cyclase
k59_1129495_1	861299.J421_3747	4.47e-52	186.0	COG1197@1|root,COG1197@2|Bacteria,1ZT88@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_294955_1	316274.Haur_1430	1.05e-26	114.0	COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,2G699@200795|Chloroflexi,3764S@32061|Chloroflexia	200795|Chloroflexi	T	PFAM adenylyl cyclase class-3 4 guanylyl cyclase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DZR,Guanylate_cyc
k59_1241479_1	877418.ATWV01000010_gene192	3.75e-06	54.7	COG2373@1|root,COG2373@2|Bacteria,2J5M0@203691|Spirochaetes	203691|Spirochaetes	S	Alpha-2-macroglobulin family	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,A2M_comp,Big_5,MG1
k59_127273_1	314292.VAS14_10089	2.95e-28	106.0	COG3791@1|root,COG3791@2|Bacteria,1RHWZ@1224|Proteobacteria,1S4HQ@1236|Gammaproteobacteria,1XXI2@135623|Vibrionales	135623|Vibrionales	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
k59_127273_2	1220535.IMCC14465_11000	3.19e-24	100.0	COG2175@1|root,COG2175@2|Bacteria,1R95X@1224|Proteobacteria,2VGYB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	PFAM taurine catabolism dioxygenase, TauD TfdA	-	-	1.14.11.17	ko:K03119	ko00430,ko00920,map00430,map00920	-	R05320	RC01331	ko00000,ko00001,ko01000	-	-	-	TauD
k59_627824_1	290318.Cvib_0289	4.5e-22	101.0	COG0457@1|root,COG0697@1|root,COG0457@2|Bacteria,COG0697@2|Bacteria,1FDC1@1090|Chlorobi	1090|Chlorobi	EG	Protein of unknown function (DUF2723)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2723
k59_1573479_1	1313172.YM304_23690	7.37e-68	221.0	COG0034@1|root,COG0034@2|Bacteria,2GK6I@201174|Actinobacteria,4CMWP@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_7,Pribosyltran
k59_517412_1	471852.Tcur_0550	7.79e-74	233.0	COG2227@1|root,COG2227@2|Bacteria,2I3C3@201174|Actinobacteria,4ER5A@85012|Streptosporangiales	201174|Actinobacteria	H	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
k59_1089470_1	484019.THA_1020	1.13e-55	187.0	COG0601@1|root,COG0601@2|Bacteria,2GBYF@200918|Thermotogae	200918|Thermotogae	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_924473_1	886293.Sinac_7190	1.06e-40	154.0	COG0642@1|root,COG0784@1|root,COG2198@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2205@2|Bacteria,2IXFD@203682|Planctomycetes	203682|Planctomycetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,PAS_3,PAS_9,Response_reg
k59_365837_1	1247726.MIM_c04380	4.78e-35	127.0	COG0066@1|root,COG0066@2|Bacteria,1NZAW@1224|Proteobacteria,2VRJ2@28216|Betaproteobacteria,3T7I2@506|Alcaligenaceae	28216|Betaproteobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	-	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
k59_365837_2	1415166.NONO_c62560	1.17e-23	99.4	COG2303@1|root,COG2303@2|Bacteria,2GJAU@201174|Actinobacteria,4FU19@85025|Nocardiaceae	201174|Actinobacteria	E	Belongs to the GMC oxidoreductase family	-	-	1.1.99.1	ko:K00108	ko00260,ko01100,map00260,map01100	M00555	R01025	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
k59_254457_1	472759.Nhal_0414	3.55e-50	174.0	COG2433@1|root,COG2433@2|Bacteria,1QW3W@1224|Proteobacteria,1T2RV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Pfam Transposase IS66	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1701892_1	641524.ADICYQ_1354	1.55e-44	160.0	COG0076@1|root,COG0076@2|Bacteria,4NFUP@976|Bacteroidetes,47NKR@768503|Cytophagia	976|Bacteroidetes	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	-	-	-	-	-	-	-	-	-	-	Pyridoxal_deC
k59_254464_2	935863.AWZR01000001_gene1623	1.09e-27	114.0	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,1RMSR@1236|Gammaproteobacteria,1X36C@135614|Xanthomonadales	135614|Xanthomonadales	M	Belongs to the peptidase S41A family	ctp	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
k59_1589610_1	1123054.KB907722_gene2905	1.62e-10	68.6	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1S720@1236|Gammaproteobacteria,1WYW3@135613|Chromatiales	135613|Chromatiales	O	Tetratricopeptide repeats	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_8,Trans_reg_C
k59_924491_1	1197906.CAJQ02000014_gene332	9.38e-71	242.0	COG2217@1|root,COG2608@1|root,COG2217@2|Bacteria,COG2608@2|Bacteria,1MU08@1224|Proteobacteria,2TR56@28211|Alphaproteobacteria,3JRCG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	E1-E2 ATPase	cadA	-	3.6.3.3,3.6.3.5	ko:K01534	-	-	-	-	ko00000,ko01000	3.A.3.6	-	-	E1-E2_ATPase,Hydrolase
k59_588054_1	1380390.JIAT01000009_gene625	3.85e-17	79.0	COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria	201174|Actinobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_588054_2	196367.JNFG01000199_gene3491	1.09e-18	87.4	COG2202@1|root,COG3829@1|root,COG4585@1|root,COG2202@2|Bacteria,COG3829@2|Bacteria,COG4585@2|Bacteria,1MWPN@1224|Proteobacteria,2VJV5@28216|Betaproteobacteria,1K5TA@119060|Burkholderiaceae	28216|Betaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,PAS_3,PAS_4,PAS_9
k59_1257642_1	392500.Swoo_1073	3.96e-75	231.0	29DWE@1|root,300UA@2|Bacteria,1RDK5@1224|Proteobacteria,1S3V9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Cytochrome P460	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_P460
k59_1478780_1	1380391.JIAS01000003_gene1766	6.56e-94	280.0	COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,2TSU4@28211|Alphaproteobacteria,2JPNH@204441|Rhodospirillales	204441|Rhodospirillales	I	Enoyl- acyl-carrier-protein reductase NADH	fabI	-	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_421905_1	1122179.KB890436_gene1414	4.98e-26	109.0	COG0265@1|root,COG0265@2|Bacteria,4NFCS@976|Bacteroidetes,1INQ7@117747|Sphingobacteriia	976|Bacteroidetes	O	COGs COG0265 Trypsin-like serine protease typically periplasmic contain C-terminal PDZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
k59_811266_1	1122622.ATWJ01000008_gene2999	2.91e-13	71.2	COG2382@1|root,COG2382@2|Bacteria,2I844@201174|Actinobacteria,4FE3S@85021|Intrasporangiaceae	201174|Actinobacteria	P	Putative esterase	-	-	-	ko:K07214	-	-	-	-	ko00000	-	-	-	DUF3327,Esterase
k59_1533493_1	1123277.KB893244_gene5172	1.33e-19	91.7	COG3386@1|root,COG3386@2|Bacteria	2|Bacteria	G	gluconolactonase activity	-	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Esterase,SGL
k59_643009_1	1396141.BATP01000039_gene1319	9.29e-76	240.0	COG1533@1|root,COG1533@2|Bacteria,46S99@74201|Verrucomicrobia,2ITTT@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
k59_1754893_1	697303.Thewi_2529	5.6e-63	211.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,42F44@68295|Thermoanaerobacterales	186801|Clostridia	V	ABC transporter, transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_1478817_1	1121930.AQXG01000001_gene1392	5.47e-88	273.0	COG2234@1|root,COG2234@2|Bacteria,4NE66@976|Bacteroidetes,1IP9S@117747|Sphingobacteriia	976|Bacteroidetes	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
k59_755382_1	1120948.KB903240_gene4064	6.08e-07	53.5	COG2084@1|root,COG2084@2|Bacteria,2GTGE@201174|Actinobacteria,4E7CY@85010|Pseudonocardiales	201174|Actinobacteria	I	Domain of unknown function (DUF1932)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1932,NAD_binding_2
k59_755382_2	756272.Plabr_1294	9.31e-16	77.4	COG1611@1|root,COG1611@2|Bacteria,2IXIR@203682|Planctomycetes	203682|Planctomycetes	S	Rossmann fold nucleotide-binding protein	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
k59_811290_1	1122917.KB899667_gene3581	3.32e-33	130.0	COG2182@1|root,COG2182@2|Bacteria,1UI3N@1239|Firmicutes,4ITV1@91061|Bacilli,277E3@186822|Paenibacillaceae	91061|Bacilli	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
k59_1478820_1	584708.Apau_0899	5.15e-27	114.0	COG1663@1|root,COG4370@1|root,COG1663@2|Bacteria,COG4370@2|Bacteria,3T9ZA@508458|Synergistetes	508458|Synergistetes	M	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)	lpxK	-	2.7.1.130	ko:K00912	ko00540,ko01100,map00540,map01100	M00060	R04657	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxK
k59_1257687_1	1089550.ATTH01000001_gene591	2.23e-16	79.0	COG0363@1|root,COG0363@2|Bacteria,4NGB9@976|Bacteroidetes,1FJK8@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	G	Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase	pgl	-	3.1.1.31	ko:K01057	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
k59_588117_1	926569.ANT_04530	1.7e-94	298.0	COG0542@1|root,COG0542@2|Bacteria,2G5RA@200795|Chloroflexi	200795|Chloroflexi	O	ATPase AAA-2 domain protein	clpC	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,HTH_17,UVR
k59_1035551_1	765910.MARPU_08215	2.2e-40	152.0	COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,1RMPC@1236|Gammaproteobacteria,1WXPW@135613|Chromatiales	135613|Chromatiales	O	Belongs to the peptidase S16 family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_32,Lon_C
k59_143183_1	1463820.JOGW01000008_gene1268	1.47e-12	72.8	COG2197@1|root,COG3903@1|root,COG2197@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,GerE
k59_1367467_1	761193.Runsl_3076	6.95e-49	172.0	COG3119@1|root,COG3119@2|Bacteria,4NEZJ@976|Bacteroidetes,47NF5@768503|Cytophagia	976|Bacteroidetes	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
k59_1089585_1	1123023.JIAI01000014_gene3736	2.17e-25	108.0	COG1252@1|root,COG1252@2|Bacteria,2GJFE@201174|Actinobacteria,4DXU1@85010|Pseudonocardiales	201174|Actinobacteria	C	NADH dehydrogenase	-	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_143205_1	1089550.ATTH01000001_gene2481	2.42e-73	230.0	COG0332@1|root,COG0332@2|Bacteria,4NEYH@976|Bacteroidetes,1FINU@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	-	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
k59_865459_2	880073.Calab_1393	4.47e-19	79.0	COG2835@1|root,COG2835@2|Bacteria,2NQ60@2323|unclassified Bacteria	2|Bacteria	S	Trm112p-like protein	ycaR	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	2.7.1.130	ko:K00912,ko:K09791	ko00540,ko01100,map00540,map01100	M00060	R04657	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Trm112p
k59_365964_2	272558.10175111	2.78e-80	247.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,4HAA6@91061|Bacilli,1ZCDY@1386|Bacillus	91061|Bacilli	IQ	reductase	fabG	GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iYO844.BSU15910	adh_short_C2
k59_1589739_1	1122201.AUAZ01000020_gene2658	1.59e-52	169.0	COG1490@1|root,COG1490@2|Bacteria,1RGTV@1224|Proteobacteria,1S61I@1236|Gammaproteobacteria,467IU@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106026,GO:0106074,GO:0140098,GO:0140101,GO:1901360	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
k59_1312622_1	637390.AFOH01000132_gene1882	3.46e-68	218.0	COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,1RMDH@1236|Gammaproteobacteria,2NCS5@225057|Acidithiobacillales	225057|Acidithiobacillales	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
k59_421996_1	1048339.KB913029_gene3060	9.08e-16	80.1	COG2030@1|root,COG2030@2|Bacteria,2H7MB@201174|Actinobacteria,4ES36@85013|Frankiales	201174|Actinobacteria	I	N-terminal half of MaoC dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydrat_N
k59_143235_1	1121104.AQXH01000001_gene1911	4.31e-61	209.0	COG5549@1|root,COG5549@2|Bacteria,4NEA0@976|Bacteroidetes,1IQA8@117747|Sphingobacteriia	976|Bacteroidetes	O	Domain of unknown function (DUF5118)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4953,DUF5117,DUF5118
k59_1367525_1	209285.XP_006695149.1	4.11e-22	101.0	COG1404@1|root,KOG1153@2759|Eukaryota,38H6S@33154|Opisthokonta,3NZK9@4751|Fungi,3QSDC@4890|Ascomycota,214WP@147550|Sordariomycetes,3U5FD@5139|Sordariales,3H9CA@35718|Chaetomiaceae	4751|Fungi	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Inhibitor_I9,Peptidase_S8
k59_311650_1	58344.JOEL01000016_gene5882	2.88e-24	105.0	COG1228@1|root,COG1228@2|Bacteria	2|Bacteria	Q	imidazolonepropionase activity	-	-	3.5.2.18	ko:K15358	ko00760,ko01120,map00760,map01120	-	R07984	RC01933	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
k59_254597_1	1121324.CLIT_4c00250	7.18e-25	108.0	COG0475@1|root,COG0569@1|root,COG0475@2|Bacteria,COG0569@2|Bacteria,1TS32@1239|Firmicutes,247XW@186801|Clostridia,25RVB@186804|Peptostreptococcaceae	186801|Clostridia	P	CPA2 family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
k59_1089634_2	316056.RPC_2070	7.36e-172	490.0	COG5433@1|root,COG5433@2|Bacteria,1MXB5@1224|Proteobacteria,2U26E@28211|Alphaproteobacteria,3K2QG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
k59_1089646_1	266835.14022849	1.56e-30	113.0	COG1230@1|root,COG1230@2|Bacteria,1MUSS@1224|Proteobacteria,2TVQN@28211|Alphaproteobacteria,43NPM@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	Cation efflux family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux
k59_1643440_1	608538.HTH_0153	3.2e-18	85.5	COG0843@1|root,COG0843@2|Bacteria	2|Bacteria	C	heme-copper terminal oxidase activity	cbaA	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_1643440_2	1437824.BN940_02346	2.27e-22	92.0	COG1622@1|root,COG1622@2|Bacteria,1NZNI@1224|Proteobacteria,2VNRT@28216|Betaproteobacteria	28216|Betaproteobacteria	C	cytochrome c oxidase (Subunit II)	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2
k59_1645254_1	65393.PCC7424_1587	6.99e-57	187.0	COG1075@1|root,COG1611@1|root,COG1075@2|Bacteria,COG1611@2|Bacteria,1GK68@1117|Cyanobacteria,3KJFV@43988|Cyanothece	1117|Cyanobacteria	S	TIR domain	-	-	-	-	-	-	-	-	-	-	-	-	TIR_2
k59_867686_1	1449347.JQLN01000001_gene253	1.49e-06	50.8	COG2365@1|root,COG2365@2|Bacteria,2GK28@201174|Actinobacteria	201174|Actinobacteria	T	Protein tyrosine serine phosphatase	-	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_10,Y_phosphatase3
k59_703022_1	1089552.KI911559_gene1068	5.01e-32	127.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,2JPQJ@204441|Rhodospirillales	204441|Rhodospirillales	C	Aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
k59_757531_1	926550.CLDAP_24400	3.15e-69	220.0	COG0309@1|root,COG0309@2|Bacteria,2G5MV@200795|Chloroflexi	200795|Chloroflexi	O	hydrogenase expression formation protein HypE	hypE	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
k59_1091666_2	1469613.JT55_05045	0.000721	45.8	COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,2TRZE@28211|Alphaproteobacteria,3FE5K@34008|Rhodovulum	28211|Alphaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	ko:K21395	-	-	-	-	ko00000,ko02000	2.A.56.1	-	-	DctP
k59_1037760_1	1121106.JQKB01000049_gene3064	2.7e-55	185.0	COG4275@1|root,COG4275@2|Bacteria,1MYDE@1224|Proteobacteria,2TV61@28211|Alphaproteobacteria,2JVSA@204441|Rhodospirillales	204441|Rhodospirillales	S	Chromate resistance exported protein	-	-	-	-	-	-	-	-	-	-	-	-	Chrome_Resist
k59_423974_1	391603.FBALC1_00702	3.15e-110	346.0	COG4447@1|root,COG4447@2|Bacteria,4NESU@976|Bacteroidetes,1HXIG@117743|Flavobacteriia	976|Bacteroidetes	G	BNR Asp-box repeat	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
k59_368018_1	373994.Riv7116_0922	6.93e-67	222.0	COG1075@1|root,COG1075@2|Bacteria,1GIQY@1117|Cyanobacteria,1HP99@1161|Nostocales	1117|Cyanobacteria	S	Alpha/beta hydrolase of unknown function (DUF900)	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_481825_1	83406.HDN1F_19800	1.85e-83	258.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RPGB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	acyl-CoA dehydrogenase	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_757566_1	1502852.FG94_04302	1.04e-38	143.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VHFW@28216|Betaproteobacteria,475Y7@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	CoA-transferase family III	-	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
k59_481862_1	671143.DAMO_0874	2.49e-112	335.0	COG0065@1|root,COG0065@2|Bacteria,2NP2K@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	GO:0003674,GO:0003824,GO:0003861,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009316,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iEcE24377_1341.EcE24377A_0075,iPC815.YPO0531,iSB619.SA_RS10700	Aconitase
k59_1147844_1	1280952.HJA_03611	5.93e-31	111.0	COG2010@1|root,COG2010@2|Bacteria,1RFJV@1224|Proteobacteria	1224|Proteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
k59_1147844_2	702113.PP1Y_AT23257	3.74e-15	72.8	COG2010@1|root,COG2010@2|Bacteria,1NA68@1224|Proteobacteria,2UMYR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
k59_867773_1	997346.HMPREF9374_0644	5.16e-84	259.0	COG0156@1|root,COG0156@2|Bacteria,1TPUX@1239|Firmicutes,4HAH3@91061|Bacilli,27B3G@186824|Thermoactinomycetaceae	91061|Bacilli	E	Cys/Met metabolism PLP-dependent enzyme	kbl	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0008890,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_481879_1	1380391.JIAS01000015_gene302	8.1e-82	258.0	COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,2TS0R@28211|Alphaproteobacteria,2JPVD@204441|Rhodospirillales	204441|Rhodospirillales	C	Electron transfer flavoprotein-ubiquinone oxidoreductase	-	-	1.5.5.1	ko:K00311	-	-	-	-	ko00000,ko01000	-	-	-	ETF_QO,FAD_binding_2,NAD_binding_8
k59_867786_1	1121022.ABENE_00175	5.56e-38	143.0	COG3664@1|root,COG3664@2|Bacteria,1MWYX@1224|Proteobacteria,2U4D0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Glycosyl hydrolases family 39	xynB	-	3.2.1.37	ko:K01198	ko00520,ko01100,map00520,map01100	-	R01433	RC00467	ko00000,ko00001,ko01000	-	GH43	-	Glyco_hydro_39
k59_1314978_1	543913.D521_0168	5.65e-09	57.4	COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,2VHJ1@28216|Betaproteobacteria,1KPNA@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	D	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
k59_1314978_2	887898.HMPREF0551_1811	3.94e-13	75.1	COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,2VI5Q@28216|Betaproteobacteria,1K0M1@119060|Burkholderiaceae	28216|Betaproteobacteria	D	Peptidoglycan polymerase that is essential for cell division	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
k59_1164567_1	644107.SL1157_0594	6.78e-38	140.0	COG0334@1|root,COG0334@2|Bacteria,1MUXS@1224|Proteobacteria,2VGKD@28211|Alphaproteobacteria,4NAUH@97050|Ruegeria	28211|Alphaproteobacteria	C	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.9	ko:K00263	ko00280,ko00290,ko01100,ko01110,ko01130,map00280,map00290,map01100,map01110,map01130	-	R01088,R01434,R02196	RC00006,RC00036	ko00000,ko00001,ko01000	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
k59_719934_1	391612.CY0110_13831	1.32e-38	142.0	COG0515@1|root,COG0515@2|Bacteria,1G08U@1117|Cyanobacteria,3KH6Q@43988|Cyanothece	1117|Cyanobacteria	KLT	Serine Threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,TPR_1,TPR_2,TPR_8
k59_498182_1	1178825.ALIH01000008_gene721	0.000171	50.1	COG0823@1|root,COG0823@2|Bacteria,4NG4S@976|Bacteroidetes,1I1I2@117743|Flavobacteriia	976|Bacteroidetes	U	WD40-like Beta Propeller Repeat	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
k59_1440334_1	293826.Amet_3032	2.43e-44	164.0	COG1480@1|root,COG1480@2|Bacteria,1TR1A@1239|Firmicutes,249W0@186801|Clostridia,36E2C@31979|Clostridiaceae	186801|Clostridia	S	SMART Metal-dependent phosphohydrolase, HD region	-	-	-	ko:K07037	-	-	-	-	ko00000	-	-	-	7TM-7TMR_HD,7TMR-HDED,HD
k59_1607219_1	742725.HMPREF9450_00666	2.79e-53	189.0	COG4225@1|root,COG4225@2|Bacteria,4PNX5@976|Bacteroidetes,2G0ZQ@200643|Bacteroidia,22VKW@171550|Rikenellaceae	2|Bacteria	S	Heparinase II/III-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Hepar_II_III
k59_214082_1	1173264.KI913949_gene2161	3.84e-28	118.0	COG0464@1|root,COG0464@2|Bacteria,1G2M7@1117|Cyanobacteria,1HE1K@1150|Oscillatoriales	1117|Cyanobacteria	O	PFAM ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA
k59_771750_2	1280950.HJO_12786	5.93e-54	186.0	COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TS2Q@28211|Alphaproteobacteria,43X6D@69657|Hyphomonadaceae	28211|Alphaproteobacteria	CG	alcohol dehydrogenase	-	-	1.1.5.2	ko:K00117	ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130	-	R06620	RC00066	ko00000,ko00001,ko01000	-	-	-	Cytochrome_CBB3,PQQ,PQQ_2
k59_1277342_1	1379270.AUXF01000002_gene1585	1.49e-23	107.0	COG0515@1|root,COG0515@2|Bacteria,1ZUMJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
k59_604361_1	1128427.KB904821_gene3637	7.56e-36	131.0	COG2912@1|root,COG2912@2|Bacteria,1G11S@1117|Cyanobacteria,1H8P0@1150|Oscillatoriales	1117|Cyanobacteria	S	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	TPR_9,Transglut_core2
k59_1052954_1	1121904.ARBP01000009_gene4264	1.27e-48	176.0	COG0577@1|root,COG0577@2|Bacteria,4NDUK@976|Bacteroidetes,47JJN@768503|Cytophagia	976|Bacteroidetes	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_1277366_1	713587.THITH_03135	3.63e-57	197.0	COG3299@1|root,COG3299@2|Bacteria,1MWKI@1224|Proteobacteria,1S0AE@1236|Gammaproteobacteria,1X0R0@135613|Chromatiales	135613|Chromatiales	S	Baseplate J-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Baseplate_J
k59_1497979_1	981369.JQMJ01000004_gene282	1.12e-55	185.0	COG2159@1|root,COG2159@2|Bacteria,2GMQY@201174|Actinobacteria,2NGZ5@228398|Streptacidiphilus	201174|Actinobacteria	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
k59_498245_1	344747.PM8797T_24796	1.32e-34	129.0	COG1409@1|root,COG1409@2|Bacteria,2J1WA@203682|Planctomycetes	203682|Planctomycetes	S	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_214115_1	1042163.BRLA_c007330	2.36e-07	58.9	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,4HA3S@91061|Bacilli,26QA9@186822|Paenibacillaceae	91061|Bacilli	V	ABC transporter, ATP-binding protein	ygaD	GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015399,GO:0015405,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0071702	-	ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106	-	-	ABC_membrane,ABC_tran
k59_1718967_1	1211815.CBYP010000002_gene1970	3.07e-68	212.0	COG0454@1|root,COG0456@2|Bacteria,2GY1D@201174|Actinobacteria	201174|Actinobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_214126_1	1379698.RBG1_1C00001G0857	9.71e-65	212.0	COG5557@1|root,COG5557@2|Bacteria,2NNNQ@2323|unclassified Bacteria	1379698.RBG1_1C00001G0857|-	C	Polysulphide reductase, NrfD	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1607274_1	1316936.K678_14744	0.000697	41.6	COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,2TRN1@28211|Alphaproteobacteria,2JPZW@204441|Rhodospirillales	204441|Rhodospirillales	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
k59_161457_1	1190603.AJYD01000026_gene3336	2.45e-10	63.5	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,1RMQB@1236|Gammaproteobacteria,1XUNK@135623|Vibrionales	135623|Vibrionales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctA
k59_1386513_2	1249997.JHZW01000002_gene1720	1.45e-44	154.0	COG0524@1|root,COG0524@2|Bacteria,4NFH8@976|Bacteroidetes,1HXXT@117743|Flavobacteriia,2PG6B@252356|Maribacter	976|Bacteroidetes	G	pfkB family carbohydrate kinase	-	-	2.7.1.45	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00061,M00308,M00631	R01541	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
k59_1498026_1	266940.Krad_3528	1.57e-53	191.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,BTAD,HTH_31,Trans_reg_C
k59_996427_1	207559.Dde_2013	6.61e-34	133.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WIWE@28221|Deltaproteobacteria,2M7YQ@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Belongs to the peptidase S1C family	degP	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
k59_943115_1	1523503.JPMY01000006_gene2249	2.43e-09	63.5	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RQ36@1236|Gammaproteobacteria	1236|Gammaproteobacteria	JKL	DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit. Has an RNA-dependent ATPase activity, which is specific for 23S rRNA, and a 3' to 5' RNA helicase activity that uses the energy of ATP hydrolysis to destabilize and unwind short rRNA duplexes	dbpA	GO:0000027,GO:0000166,GO:0003674,GO:0003676,GO:0003723,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008144,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0033677,GO:0034458,GO:0034459,GO:0034622,GO:0034641,GO:0035639,GO:0036094,GO:0042254,GO:0042255,GO:0042273,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043531,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0065003,GO:0070035,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:0140098,GO:1901265,GO:1901360,GO:1901363	3.6.4.13	ko:K05591	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	DEAD,DbpA,Helicase_C
k59_1277437_1	262724.TT_C0106	2.29e-72	229.0	COG0037@1|root,COG0037@2|Bacteria,1WIQC@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	D	Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system	ttcA	-	2.8.1.15	ko:K14058,ko:K21947	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3
k59_105748_1	1122165.AUHS01000004_gene3159	1.24e-47	169.0	COG2826@1|root,COG2826@2|Bacteria,1MWI0@1224|Proteobacteria,1RRSE@1236|Gammaproteobacteria,1JEXQ@118969|Legionellales	118969|Legionellales	L	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_38,rve
k59_550146_1	290402.Cbei_1206	1.59e-18	88.2	COG0196@1|root,COG0196@2|Bacteria,1TPKS@1239|Firmicutes,2484A@186801|Clostridia,36EA2@31979|Clostridiaceae	186801|Clostridia	H	Belongs to the ribF family	ribF	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
k59_720082_1	553385.JEMF01000019_gene1061	5.12e-68	226.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,1RMIT@1236|Gammaproteobacteria,1XIJT@135619|Oceanospirillales	135619|Oceanospirillales	M	gamma-glutamyltransferase	ggt	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k59_604447_1	570967.JMLV01000004_gene673	1.64e-54	179.0	COG3175@1|root,COG3175@2|Bacteria,1RDTU@1224|Proteobacteria,2U6ZT@28211|Alphaproteobacteria,2JSCM@204441|Rhodospirillales	204441|Rhodospirillales	O	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I	-	-	-	-	-	-	-	-	-	-	-	-	CtaG_Cox11
k59_604447_2	570967.JMLV01000004_gene674	1.76e-10	60.1	COG2847@1|root,COG2847@2|Bacteria,1Q3NX@1224|Proteobacteria,2UIQF@28211|Alphaproteobacteria,2JZST@204441|Rhodospirillales	204441|Rhodospirillales	S	Copper chaperone PCu(A)C	-	-	-	-	-	-	-	-	-	-	-	-	PCuAC
k59_384611_1	234267.Acid_0353	1.2e-22	95.1	COG0022@1|root,COG0022@2|Bacteria,3Y48G@57723|Acidobacteria	57723|Acidobacteria	C	Transketolase, pyrimidine binding domain	-	-	1.2.4.4	ko:K00167	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
k59_384611_2	979556.MTES_3457	5.64e-25	108.0	COG0508@1|root,COG0508@2|Bacteria,2GMUV@201174|Actinobacteria,4FK9I@85023|Microbacteriaceae	201174|Actinobacteria	C	e3 binding domain	sucB	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_1277484_1	926569.ANT_19800	9.81e-55	191.0	COG0210@1|root,COG0210@2|Bacteria,2G7VU@200795|Chloroflexi	200795|Chloroflexi	F	DNA helicase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_105785_1	1189619.pgond44_05365	1.04e-103	318.0	COG2759@1|root,COG2759@2|Bacteria,4NG3E@976|Bacteroidetes,1HXR5@117743|Flavobacteriia,4C43R@83612|Psychroflexus	976|Bacteroidetes	F	Formate--tetrahydrofolate ligase	fhs	GO:0003674,GO:0003824,GO:0004329,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006144,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009112,GO:0009113,GO:0009256,GO:0009257,GO:0009396,GO:0009987,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0016874,GO:0016879,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042440,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
k59_720123_1	570952.ATVH01000016_gene2561	3.15e-93	294.0	COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,2TQJT@28211|Alphaproteobacteria,2JPC0@204441|Rhodospirillales	204441|Rhodospirillales	C	malic enzyme	dme	-	1.1.1.40	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00169,M00172	R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,PTA_PTB,malic
k59_828762_1	1410668.JNKC01000003_gene387	1.71e-84	260.0	COG1879@1|root,COG1879@2|Bacteria,1TQ1B@1239|Firmicutes,25BRG@186801|Clostridia,36GIU@31979|Clostridiaceae	186801|Clostridia	G	Periplasmic binding proteins and sugar binding domain of LacI family	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
k59_1549372_1	595460.RRSWK_03757	2.47e-101	327.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,2IYDT@203682|Planctomycetes	203682|Planctomycetes	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	-	-	-	-	-	-	-	-	-	-	-	-	EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_1107592_1	1206741.BAFX01000108_gene1071	1.11e-52	189.0	COG0243@1|root,COG1018@1|root,COG0243@2|Bacteria,COG1018@2|Bacteria,2GNYQ@201174|Actinobacteria,4FUC7@85025|Nocardiaceae	201174|Actinobacteria	C	Molydopterin dinucleotide binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_6,Fer2,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NAD_binding_1
k59_1440482_1	420662.Mpe_A2711	5.33e-08	53.1	COG1396@1|root,COG1396@2|Bacteria,1NGFD@1224|Proteobacteria,2VXDF@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31
k59_661105_1	765913.ThidrDRAFT_2426	2.99e-42	157.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WW0R@135613|Chromatiales	135613|Chromatiales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_333297_1	1532558.JL39_02410	7.15e-63	214.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria,4BDJQ@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_1499915_1	419947.MRA_0394	5.08e-07	54.7	COG2114@1|root,COG2197@1|root,COG3903@1|root,COG2114@2|Bacteria,COG2197@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,233DM@1762|Mycobacteriaceae	201174|Actinobacteria	K	involved in signal transduction (via phosphorylation) involved in transcriptional regulatory mechanism and in the regulation of secondary metabolites catalytic activity ATP a protein ADP a phosphoprotein	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Guanylate_cyc,NB-ARC
k59_1499915_2	1123319.AUBE01000007_gene3687	6.15e-65	207.0	COG0454@1|root,COG0456@2|Bacteria,2GNE2@201174|Actinobacteria	201174|Actinobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_215563_1	991905.SL003B_1214	1.64e-91	288.0	COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,2TT32@28211|Alphaproteobacteria,4BPGY@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009380,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0071496,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
k59_333299_1	342610.Patl_1560	2.09e-37	148.0	COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,1RN9H@1236|Gammaproteobacteria,2PZJ5@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	M	Catalyzes cross-linking of the peptidoglycan cell wall	mrdA	GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042493,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0045229,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:0071972,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	iEcE24377_1341.EcE24377A_0661,iPC815.YPO2604	PBP_dimer,Transpeptidase
k59_830418_1	1242864.D187_007991	1.17e-50	172.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,42NI4@68525|delta/epsilon subdivisions,2WKRT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	ABC transporter	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
k59_1499926_1	215803.DB30_8592	1.12e-68	235.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1QK4F@1224|Proteobacteria,43BZC@68525|delta/epsilon subdivisions,2X7A3@28221|Deltaproteobacteria,2YWPR@29|Myxococcales	28221|Deltaproteobacteria	Q	Thioesterase domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,Ketoacyl-synt_C,Methyltransf_12,PP-binding,Thioesterase,ketoacyl-synt
k59_51072_1	1265502.KB905958_gene234	2.08e-92	296.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,2VP2Q@28216|Betaproteobacteria,4AAQA@80864|Comamonadaceae	28216|Betaproteobacteria	C	formate dehydrogenase, alpha subunit	fdhA1	-	1.17.1.9,1.17.99.7	ko:K00123,ko:K22015	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_1442112_1	237368.SCABRO_02910	1.84e-15	79.7	COG0644@1|root,COG0644@2|Bacteria,2J1WS@203682|Planctomycetes	203682|Planctomycetes	C	oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1662645_1	1227739.Hsw_2651	6.42e-39	142.0	COG2301@1|root,COG2301@2|Bacteria,4NJ95@976|Bacteroidetes,47T2T@768503|Cytophagia	976|Bacteroidetes	G	Belongs to the HpcH HpaI aldolase family	-	-	-	-	-	-	-	-	-	-	-	-	HpcH_HpaI
k59_1662645_2	698440.XP_007294956.1	8.35e-07	52.8	COG3648@1|root,KOG1599@2759|Eukaryota,38FJ4@33154|Opisthokonta,3NWXW@4751|Fungi,3QP7E@4890|Ascomycota,20W6T@147548|Leotiomycetes	4751|Fungi	Q	Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin	-	GO:0003674,GO:0003824,GO:0004846,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0006139,GO:0006144,GO:0006145,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016491,GO:0016661,GO:0016663,GO:0019439,GO:0019627,GO:0034641,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0055114,GO:0071704,GO:0071941,GO:0072521,GO:0072523,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575	1.7.3.3	ko:K00365	ko00230,ko00232,ko01100,ko01120,map00230,map00232,map01100,map01120	M00546	R02106,R07981	RC02107,RC02551	ko00000,ko00001,ko00002,ko01000	-	-	-	Uricase
k59_887365_1	99598.Cal7507_2756	1.47e-45	168.0	COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria	1117|Cyanobacteria	Q	Amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,NAD_binding_4,PP-binding,TPR_1,TPR_8,Thioesterase
k59_1662664_1	523845.AQXV01000040_gene1694	1.66e-13	74.7	COG1976@1|root,arCOG04176@2157|Archaea,2XU7N@28890|Euryarchaeota,23QQR@183939|Methanococci	183939|Methanococci	J	Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex	eif6	GO:0000460,GO:0000470,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0030684,GO:0030687,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042273,GO:0043021,GO:0043023,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046483,GO:0065003,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360,GO:1902626,GO:1990904	-	ko:K03264	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009,ko03012	-	-	-	eIF-6
k59_272089_1	886293.Sinac_1119	2.9e-56	190.0	COG1262@1|root,COG1262@2|Bacteria,2IXRC@203682|Planctomycetes	203682|Planctomycetes	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2,FGE-sulfatase
k59_661163_1	1123366.TH3_04609	5.44e-48	174.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,2JPRP@204441|Rhodospirillales	204441|Rhodospirillales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_830472_1	1120949.KB903339_gene8070	3.7e-31	127.0	COG2267@1|root,COG3710@1|root,COG2267@2|Bacteria,COG3710@2|Bacteria,2I75H@201174|Actinobacteria	201174|Actinobacteria	I	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
k59_1662675_1	93220.LV28_15005	2.36e-62	209.0	COG1274@1|root,COG1274@2|Bacteria,1MX3C@1224|Proteobacteria,2VINZ@28216|Betaproteobacteria,1JZXA@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	GO:0000003,GO:0001655,GO:0001822,GO:0001889,GO:0003006,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004457,GO:0004611,GO:0004613,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005975,GO:0005996,GO:0006006,GO:0006007,GO:0006066,GO:0006071,GO:0006082,GO:0006089,GO:0006090,GO:0006091,GO:0006094,GO:0006109,GO:0006111,GO:0006113,GO:0006139,GO:0006163,GO:0006464,GO:0006629,GO:0006631,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006735,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007028,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007296,GO:0007610,GO:0008150,GO:0008152,GO:0008906,GO:0009056,GO:0009058,GO:0009062,GO:0009117,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009166,GO:0009167,GO:0009179,GO:0009185,GO:0009199,GO:0009205,GO:0009259,GO:0009410,GO:0009605,GO:0009636,GO:0009653,GO:0009719,GO:0009725,GO:0009790,GO:0009792,GO:0009887,GO:0009888,GO:0009889,GO:0009966,GO:0009967,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010646,GO:0010647,GO:0010675,GO:0010906,GO:0014070,GO:0014074,GO:0015036,GO:0015980,GO:0016042,GO:0016043,GO:0016051,GO:0016052,GO:0016053,GO:0016054,GO:0016301,GO:0016310,GO:0016491,GO:0016614,GO:0016651,GO:0016667,GO:0016668,GO:0016740,GO:0016772,GO:0016773,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017001,GO:0017144,GO:0018130,GO:0018991,GO:0019098,GO:0019222,GO:0019249,GO:0019318,GO:0019319,GO:0019320,GO:0019362,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019516,GO:0019538,GO:0019541,GO:0019543,GO:0019563,GO:0019626,GO:0019637,GO:0019659,GO:0019660,GO:0019661,GO:0019666,GO:0019674,GO:0019693,GO:0019751,GO:0019752,GO:0019953,GO:0022412,GO:0022414,GO:0023051,GO:0023056,GO:0030145,GO:0030154,GO:0030703,GO:0030855,GO:0031323,GO:0031667,GO:0031960,GO:0031974,GO:0032501,GO:0032502,GO:0032504,GO:0032787,GO:0032868,GO:0032869,GO:0032870,GO:0033993,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035690,GO:0036211,GO:0042221,GO:0042493,GO:0042594,GO:0042737,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043255,GO:0043412,GO:0043434,GO:0043436,GO:0043687,GO:0043900,GO:0043903,GO:0043949,GO:0043950,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044267,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0045471,GO:0046031,GO:0046034,GO:0046164,GO:0046174,GO:0046364,GO:0046365,GO:0046394,GO:0046395,GO:0046434,GO:0046459,GO:0046483,GO:0046496,GO:0046677,GO:0046683,GO:0046700,GO:0046872,GO:0046914,GO:0047134,GO:0048468,GO:0048477,GO:0048513,GO:0048518,GO:0048522,GO:0048545,GO:0048562,GO:0048568,GO:0048583,GO:0048584,GO:0048598,GO:0048609,GO:0048646,GO:0048731,GO:0048732,GO:0048856,GO:0048869,GO:0050789,GO:0050792,GO:0050794,GO:0050896,GO:0051186,GO:0051384,GO:0051591,GO:0051704,GO:0051716,GO:0055086,GO:0055114,GO:0060429,GO:0061005,GO:0061008,GO:0062012,GO:0065007,GO:0070013,GO:0070365,GO:0070887,GO:0071236,GO:0071310,GO:0071361,GO:0071375,GO:0071383,GO:0071384,GO:0071385,GO:0071396,GO:0071407,GO:0071417,GO:0071466,GO:0071495,GO:0071548,GO:0071549,GO:0071704,GO:0071840,GO:0072001,GO:0072071,GO:0072329,GO:0072330,GO:0072521,GO:0072524,GO:0080090,GO:0097159,GO:0097237,GO:0097305,GO:0097306,GO:0097327,GO:1901135,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901575,GO:1901576,GO:1901615,GO:1901616,GO:1901617,GO:1901652,GO:1901653,GO:1901654,GO:1901655,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902531,GO:1902533	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_C,PEPCK_N
k59_1388480_1	4538.ORGLA04G0159500.1	5.37e-06	53.9	COG2986@1|root,KOG0222@2759|Eukaryota,37M4G@33090|Viridiplantae,3G9T5@35493|Streptophyta,3M5P5@4447|Liliopsida,3IN64@38820|Poales	35493|Streptophyta	H	Phenylalanine ammonia-lyase	PAL2	GO:0001101,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006725,GO:0006950,GO:0006979,GO:0007275,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009314,GO:0009411,GO:0009414,GO:0009415,GO:0009416,GO:0009555,GO:0009628,GO:0009696,GO:0009698,GO:0009699,GO:0009808,GO:0009819,GO:0009987,GO:0010035,GO:0010224,GO:0010817,GO:0016054,GO:0016829,GO:0016840,GO:0016841,GO:0016999,GO:0017001,GO:0017144,GO:0018958,GO:0019336,GO:0019438,GO:0019439,GO:0019748,GO:0019752,GO:0032501,GO:0032502,GO:0032787,GO:0032991,GO:0042221,GO:0042445,GO:0042447,GO:0042537,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0044550,GO:0045548,GO:0046244,GO:0046271,GO:0046274,GO:0046395,GO:0048229,GO:0048856,GO:0050896,GO:0065007,GO:0065008,GO:0071704,GO:0072329,GO:0080167,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576,GO:1901615,GO:1901616,GO:1901700	4.3.1.24,4.3.1.25	ko:K10775,ko:K13064	ko00360,ko00940,ko01100,ko01110,map00360,map00940,map01100,map01110	M00039,M00137,M00350	R00697,R00737	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
k59_51128_1	999541.bgla_1g13440	1.58e-33	125.0	COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,2VH2Q@28216|Betaproteobacteria,1K2R5@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
k59_661182_1	1129794.C427_2737	2.36e-42	156.0	COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,1RMNX@1236|Gammaproteobacteria,465XA@72275|Alteromonadaceae	1236|Gammaproteobacteria	KL	COG1199 Rad3-related DNA helicases	yoaA	GO:0003674,GO:0003824,GO:0004386,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008026,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0070035,GO:0071704,GO:0090304,GO:1901360	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_2,Helicase_C_2,ResIII
k59_1109296_1	396588.Tgr7_0189	2.19e-19	86.7	COG1192@1|root,COG1192@2|Bacteria,1QBJX@1224|Proteobacteria,1S739@1236|Gammaproteobacteria	1236|Gammaproteobacteria	D	involved in chromosome partitioning	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31,CbiA
k59_272123_1	1121405.dsmv_2602	1.1e-11	65.1	COG0642@1|root,COG0715@1|root,COG5002@1|root,COG0642@2|Bacteria,COG0715@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,42NK9@68525|delta/epsilon subdivisions,2X7E0@28221|Deltaproteobacteria,2MITZ@213118|Desulfobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,PAS,PAS_4,PAS_9,Response_reg,SBP_bac_3
k59_721992_1	416348.Hlac_0188	2.9e-14	76.3	COG0451@1|root,arCOG03095@2157|Archaea,2XTPI@28890|Euryarchaeota,23STT@183963|Halobacteria	183963|Halobacteria	M	NAD-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase,NAD_binding_10
k59_1662714_1	926550.CLDAP_13040	1.55e-42	150.0	COG1173@1|root,COG1173@2|Bacteria,2G6HB@200795|Chloroflexi	200795|Chloroflexi	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
k59_721998_1	666686.B1NLA3E_21365	1.43e-06	50.4	COG0839@1|root,COG0839@2|Bacteria,1V48R@1239|Firmicutes,4HJAV@91061|Bacilli,1ZFW1@1386|Bacillus	91061|Bacilli	C	Belongs to the complex I subunit 6 family	nuoJ	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
k59_721998_2	926569.ANT_08390	7.59e-37	127.0	COG0713@1|root,COG0713@2|Bacteria,2G6TP@200795|Chloroflexi	200795|Chloroflexi	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
k59_1500035_1	314256.OG2516_08783	1.2e-14	77.0	COG2186@1|root,COG2186@2|Bacteria,1MXN5@1224|Proteobacteria,2U1II@28211|Alphaproteobacteria,2PCTI@252301|Oceanicola	28211|Alphaproteobacteria	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
k59_1500042_1	498211.CJA_0703	1.94e-47	153.0	COG0185@1|root,COG0185@2|Bacteria,1RGYX@1224|Proteobacteria,1S5VT@1236|Gammaproteobacteria,1FHNZ@10|Cellvibrio	1236|Gammaproteobacteria	J	Ribosomal protein S19	rpsS	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
k59_287889_1	926569.ANT_28690	2.3e-47	163.0	COG3868@1|root,COG3868@2|Bacteria,2G983@200795|Chloroflexi	200795|Chloroflexi	S	Carbohydrate family 9 binding domain-like	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
k59_1677549_1	1123251.ATWM01000008_gene2553	8.98e-79	253.0	COG0481@1|root,COG0481@2|Bacteria,2GJAB@201174|Actinobacteria,4FEI5@85021|Intrasporangiaceae	201174|Actinobacteria	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
k59_398950_1	497965.Cyan7822_2100	3.7e-22	97.8	COG2211@1|root,COG2211@2|Bacteria,1G0ZY@1117|Cyanobacteria,3KGM5@43988|Cyanothece	1117|Cyanobacteria	G	TIGRFAM sugar (Glycoside-Pentoside-Hexuronide) transporter	melB	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
k59_343092_1	244582.JQAK01000001_gene1424	5.07e-55	177.0	COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,2U6Z9@28211|Alphaproteobacteria,47FEP@766|Rickettsiales	766|Rickettsiales	O	bacterioferritin comigratory protein	bcp	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
k59_677217_2	1282876.BAOK01000002_gene332	2.68e-34	129.0	COG2133@1|root,COG2133@2|Bacteria,1MVK5@1224|Proteobacteria,2TRN9@28211|Alphaproteobacteria,4BQIN@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
k59_398953_1	926569.ANT_11210	3.42e-59	197.0	COG3404@1|root,COG3643@1|root,COG3404@2|Bacteria,COG3643@2|Bacteria,2G64T@200795|Chloroflexi	200795|Chloroflexi	E	Formiminotransferase domain, N-terminal subdomain	-	-	2.1.2.5,4.3.1.4	ko:K00603,ko:K13990	ko00340,ko00670,ko01100,map00340,map00670,map01100	-	R02287,R02302,R03189	RC00165,RC00221,RC00223,RC00688,RC00870	ko00000,ko00001,ko01000,ko03036,ko04147	-	-	-	FTCD,FTCD_C,FTCD_N
k59_1566495_1	1123355.JHYO01000008_gene2605	0.000704	46.6	COG4977@1|root,COG4977@2|Bacteria,1MUDK@1224|Proteobacteria,2TS7I@28211|Alphaproteobacteria,3707Q@31993|Methylocystaceae	28211|Alphaproteobacteria	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI,HTH_18
k59_1621658_1	1380356.JNIK01000016_gene3544	9.84e-62	199.0	COG2356@1|root,COG2356@2|Bacteria,2GJ38@201174|Actinobacteria,4ESGG@85013|Frankiales	201174|Actinobacteria	L	Protein of unknown function (DUF1524)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1524,Excalibur
k59_1177318_1	1408424.JHYI01000039_gene2662	9.39e-08	60.1	COG1352@1|root,COG2201@1|root,COG4191@1|root,COG1352@2|Bacteria,COG2201@2|Bacteria,COG4191@2|Bacteria,1VCNJ@1239|Firmicutes,4HVBX@91061|Bacilli,1ZS41@1386|Bacillus	91061|Bacilli	T	Histidine kinase	-	-	2.1.1.80,3.1.1.61	ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,CheR,CheR_N,HATPase_c,HisKA,PAS_10,PAS_4,PAS_9
k59_1010775_2	926569.ANT_16960	3.36e-49	171.0	COG2262@1|root,COG2262@2|Bacteria,2G634@200795|Chloroflexi	200795|Chloroflexi	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
k59_1010776_1	479433.Caci_7600	3.71e-10	65.9	COG1300@1|root,COG1300@2|Bacteria,2GJTG@201174|Actinobacteria	201174|Actinobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIM
k59_788347_1	1182553.XP_007749277.1	8.55e-26	110.0	COG0154@1|root,KOG1211@2759|Eukaryota,39UAN@33154|Opisthokonta,3P017@4751|Fungi,3QJEI@4890|Ascomycota,20ABX@147545|Eurotiomycetes,3MQ1Q@451870|Chaetothyriomycetidae	4751|Fungi	J	Amidase	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
k59_1677580_1	517418.Ctha_1735	3.97e-71	226.0	COG4663@1|root,COG4663@2|Bacteria,1FDID@1090|Chlorobi	1090|Chlorobi	C	PFAM TRAP dicarboxylate transporter- DctP subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_343126_1	1278309.KB907110_gene3169	5.81e-45	155.0	arCOG08211@1|root,2ZBM3@2|Bacteria,1RIRV@1224|Proteobacteria,1SFXN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_454825_1	926569.ANT_16640	9.21e-98	292.0	COG0552@1|root,COG0552@2|Bacteria,2G63M@200795|Chloroflexi	200795|Chloroflexi	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
k59_1621696_1	555079.Toce_1427	7.92e-52	182.0	COG1080@1|root,COG1080@2|Bacteria,1TPK8@1239|Firmicutes,248QP@186801|Clostridia,42FHW@68295|Thermoanaerobacterales	186801|Clostridia	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ptsP	-	2.7.3.9,2.7.9.2	ko:K01007,ko:K08483	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,ko02060,map00620,map00680,map00720,map01100,map01120,map01200,map02060	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
k59_1399654_2	649747.HMPREF0083_01561	1.08e-42	152.0	COG0001@1|root,COG0001@2|Bacteria,1TPNH@1239|Firmicutes,4HV0C@91061|Bacilli,271MY@186822|Paenibacillaceae	91061|Bacilli	E	Aminotransferase class-III	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_3
k59_1510921_1	519442.Huta_2278	1.04e-20	96.7	COG1042@1|root,arCOG01338@2157|Archaea,arCOG01340@2157|Archaea,2XT9G@28890|Euryarchaeota,23SB7@183963|Halobacteria	183963|Halobacteria	C	COG1042 Acyl-CoA synthetase (NDP forming)	acdA	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
k59_1288460_1	639030.JHVA01000001_gene2358	7.48e-16	72.8	COG1695@1|root,COG1695@2|Bacteria,3Y4XD@57723|Acidobacteria,2JJIX@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
k59_1234065_1	247490.KSU1_D0754	1.3e-65	211.0	COG3039@1|root,COG3039@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_5
k59_1399669_1	926569.ANT_14810	8.36e-77	254.0	COG1529@1|root,COG2080@1|root,COG1529@2|Bacteria,COG2080@2|Bacteria,2G65D@200795|Chloroflexi	200795|Chloroflexi	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2
k59_1455693_1	1286106.MPL1_00792	2.72e-38	141.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RRXX@1236|Gammaproteobacteria,45ZZX@72273|Thiotrichales	72273|Thiotrichales	T	response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	DUF229,HTH_8,Response_reg,Sigma54_activ_2,Sigma54_activat
k59_1010843_1	1034345.CAEM01000007_gene1350	1.98e-47	169.0	COG2759@1|root,COG2759@2|Bacteria,2GT0X@201174|Actinobacteria,4CUYS@84998|Coriobacteriia	84998|Coriobacteriia	H	Belongs to the formate--tetrahydrofolate ligase family	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
k59_1066168_1	285535.JOEY01000045_gene1791	2.15e-27	110.0	COG3547@1|root,COG3547@2|Bacteria,2GS79@201174|Actinobacteria	201174|Actinobacteria	L	Transposase IS116 IS110 IS902	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1566588_1	861299.J421_3024	4.9e-122	371.0	COG1012@1|root,COG1012@2|Bacteria,1ZT7A@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_843478_1	269796.Rru_A0665	2.3e-16	74.3	COG3437@1|root,COG3437@2|Bacteria,1QXI4@1224|Proteobacteria,2TXB8@28211|Alphaproteobacteria,2JWWR@204441|Rhodospirillales	204441|Rhodospirillales	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
k59_843478_2	1382303.JPOM01000001_gene84	8.98e-41	149.0	COG4251@1|root,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,2TSPY@28211|Alphaproteobacteria,2KGQK@204458|Caulobacterales	204458|Caulobacterales	T	CHASE3 domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,HATPase_c,HisKA
k59_1733191_1	1121441.AUCX01000003_gene2961	1.44e-27	110.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,42N8U@68525|delta/epsilon subdivisions,2WJAN@28221|Deltaproteobacteria,2M8J0@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Belongs to the citrate synthase family	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
k59_1234112_1	1177181.T9A_02231	4.87e-43	153.0	COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,1RR2F@1236|Gammaproteobacteria,1XN78@135619|Oceanospirillales	135619|Oceanospirillales	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA,HrcA_DNA-bdg
k59_65411_1	1500257.JQNM01000008_gene1237	9.29e-20	90.9	COG0834@1|root,COG0834@2|Bacteria,1N6H5@1224|Proteobacteria,2U5FP@28211|Alphaproteobacteria,4BMC9@82115|Rhizobiaceae	28211|Alphaproteobacteria	ET	Bacterial periplasmic substrate-binding proteins	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
k59_843497_1	322710.Avin_05920	3.39e-68	227.0	COG2225@1|root,COG2225@2|Bacteria,1MVEV@1224|Proteobacteria,1RPVI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA	glcB	GO:0003674,GO:0003824,GO:0004474,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016740,GO:0016746,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046912,GO:0055114,GO:0071704,GO:0072350	2.3.3.9	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472	RC00004,RC00308,RC02747	ko00000,ko00001,ko00002,ko01000	-	-	iJN746.PP_0356	Malate_synthase
k59_1344042_1	269799.Gmet_1877	9.43e-42	151.0	COG0618@1|root,COG0618@2|Bacteria,1N0JS@1224|Proteobacteria,42P1S@68525|delta/epsilon subdivisions,2WJV0@28221|Deltaproteobacteria,43SCM@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	DHH family	-	-	-	-	-	-	-	-	-	-	-	-	DHH,DHHA1
k59_1566618_1	448385.sce7105	1.17e-78	248.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,42MSR@68525|delta/epsilon subdivisions,2WIXG@28221|Deltaproteobacteria,2YUF5@29|Myxococcales	28221|Deltaproteobacteria	I	Belongs to the thiolase family	bamN	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_1066201_1	1118235.CAJH01000037_gene2284	7.06e-24	100.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1T1IW@1236|Gammaproteobacteria,1X3YG@135614|Xanthomonadales	135614|Xanthomonadales	T	Fis family transcriptional regulator	fleQ	-	-	ko:K10941	ko02020,ko02025,ko05111,map02020,map02025,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	FleQ,HTH_8,Sigma54_activat
k59_565626_1	1869.MB27_40810	6.81e-20	87.4	COG0479@1|root,COG0479@2|Bacteria,2GP9C@201174|Actinobacteria,4D9G8@85008|Micromonosporales	201174|Actinobacteria	C	Succinate dehydrogenase and fumarate reductase iron-sulfur protein	sdhB1	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv0247c	Fer2_3,Fer4_8
k59_565626_2	1286106.MPL1_12381	3.11e-20	87.4	2EDAV@1|root,33776@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_677360_1	926569.ANT_05830	2.19e-109	326.0	COG1883@1|root,COG1883@2|Bacteria	2|Bacteria	C	oxaloacetate decarboxylase activity	oadB	-	4.1.1.3	ko:K01572	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	OAD_beta
k59_1733222_2	1382356.JQMP01000003_gene1447	2.54e-06	52.0	COG0845@1|root,COG0845@2|Bacteria,2G6RK@200795|Chloroflexi	200795|Chloroflexi	M	PFAM secretion protein HlyD family protein	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
k59_399092_1	1046714.AMRX01000004_gene3353	3.16e-06	51.2	COG2206@1|root,COG2206@2|Bacteria,1MW7F@1224|Proteobacteria,1RPEZ@1236|Gammaproteobacteria,464BT@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	COG2206 HD-GYP domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3391,HD,HD_5
k59_454923_1	926569.ANT_01770	6.43e-56	186.0	COG0438@1|root,COG0438@2|Bacteria,2G6KX@200795|Chloroflexi	200795|Chloroflexi	M	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4
k59_289648_1	1248916.ANFY01000006_gene1956	4.56e-06	55.5	COG3349@1|root,COG3349@2|Bacteria,1N0QS@1224|Proteobacteria,2U39T@28211|Alphaproteobacteria,2K9HY@204457|Sphingomonadales	204457|Sphingomonadales	S	NAD(P)-binding Rossmann-like domain	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_8
k59_679008_1	388413.ALPR1_05715	6.17e-64	210.0	COG1233@1|root,COG1233@2|Bacteria,4NF31@976|Bacteroidetes,47KN2@768503|Cytophagia	976|Bacteroidetes	Q	Flavin containing amine oxidoreductase	pys	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
k59_1679243_1	498211.CJA_1911	1.45e-28	118.0	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,1RNA6@1236|Gammaproteobacteria,1FGBQ@10|Cellvibrio	1236|Gammaproteobacteria	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
k59_1345617_1	1267535.KB906767_gene1124	1.78e-32	132.0	COG0577@1|root,COG0577@2|Bacteria,3Y6YF@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_344781_1	926566.Terro_3334	1.01e-23	105.0	COG2010@1|root,COG4993@1|root,COG2010@2|Bacteria,COG4993@2|Bacteria,3Y6BM@57723|Acidobacteria,2JKSS@204432|Acidobacteriia	204432|Acidobacteriia	CG	PQQ enzyme repeat	-	-	1.1.5.2	ko:K00117	ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130	-	R06620	RC00066	ko00000,ko00001,ko01000	-	-	-	Cytochrome_CBB3,PQQ,PQQ_2
k59_1457358_1	1003195.SCAT_5798	1.43e-17	87.4	COG0477@1|root,COG0477@2|Bacteria,2GJ7J@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
k59_344782_1	396588.Tgr7_0496	1.7e-88	268.0	COG1132@1|root,COG1132@2|Bacteria,1MX5V@1224|Proteobacteria,1RY02@1236|Gammaproteobacteria,1WXG2@135613|Chromatiales	135613|Chromatiales	V	(ABC) transporter	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_234117_1	880072.Desac_0492	5.86e-33	132.0	COG0784@1|root,COG2203@1|root,COG4191@1|root,COG5000@1|root,COG0784@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,COG5000@2|Bacteria,1RCM9@1224|Proteobacteria,42M1R@68525|delta/epsilon subdivisions,2WK3J@28221|Deltaproteobacteria,2MSIC@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,SBP_bac_3
k59_178116_1	36080.S2JDN0	1.3e-17	85.5	COG2303@1|root,2QSD8@2759|Eukaryota,38CB7@33154|Opisthokonta,3NUKJ@4751|Fungi,1GSNR@112252|Fungi incertae sedis	4751|Fungi	E	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
k59_178116_2	926569.ANT_03630	1.21e-08	56.2	COG5322@1|root,COG5322@2|Bacteria,2G8N0@200795|Chloroflexi	200795|Chloroflexi	S	PFAM Shikimate quinate 5-dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Shikimate_DH
k59_289713_1	1007096.BAGW01000004_gene1666	5.1e-37	132.0	COG0241@1|root,COG0241@2|Bacteria,1UXGW@1239|Firmicutes,25MSQ@186801|Clostridia,2N8NW@216572|Oscillospiraceae	186801|Clostridia	E	Polynucleotide kinase 3 phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_like
k59_1623321_1	926569.ANT_12010	1e-89	273.0	COG0533@1|root,COG0533@2|Bacteria,2G5V0@200795|Chloroflexi	200795|Chloroflexi	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0019538,GO:0043170,GO:0044238,GO:0071704,GO:1901564	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
k59_234141_1	1288494.EBAPG3_18910	6.8e-59	198.0	COG0277@1|root,COG0277@2|Bacteria,1RKIM@1224|Proteobacteria,2WB50@28216|Betaproteobacteria,3740K@32003|Nitrosomonadales	28216|Betaproteobacteria	C	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_4
k59_456587_2	590998.Celf_2919	3.83e-05	45.8	COG1722@1|root,COG1722@2|Bacteria,2GR0U@201174|Actinobacteria	201174|Actinobacteria	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
k59_456587_3	1274524.BSONL12_14769	3.28e-11	62.0	COG1963@1|root,COG1963@2|Bacteria,1VAVC@1239|Firmicutes,4HHA6@91061|Bacilli,1ZFKA@1386|Bacillus	91061|Bacilli	S	protein conserved in bacteria	yuiD	-	-	ko:K09775	-	-	-	-	ko00000	-	-	-	DUF212
k59_1623332_1	1379270.AUXF01000006_gene265	4.77e-97	300.0	COG0504@1|root,COG0504@2|Bacteria,1ZT0J@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
k59_901642_1	1121930.AQXG01000002_gene2370	9.77e-06	46.6	COG0239@1|root,COG0239@2|Bacteria,4NV3N@976|Bacteroidetes,1IUJE@117747|Sphingobacteriia	976|Bacteroidetes	D	CrcB-like protein, Camphor Resistance (CrcB)	crcB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
k59_901642_2	671143.DAMO_2925	7.02e-44	145.0	COG1993@1|root,COG1993@2|Bacteria,2NPXF@2323|unclassified Bacteria	2|Bacteria	T	Uncharacterized ACR, COG1993	-	-	-	ko:K06199,ko:K09137	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CBS,DUF190
k59_901642_3	272134.KB731324_gene1337	1.47e-13	67.8	COG1670@1|root,COG1670@2|Bacteria,1G5GV@1117|Cyanobacteria,1HAQ0@1150|Oscillatoriales	1117|Cyanobacteria	J	PFAM Acetyltransferase (GNAT) family	-	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
k59_1124064_1	715451.ambt_07655	1.18e-30	124.0	COG0366@1|root,COG0366@2|Bacteria,1MU90@1224|Proteobacteria,1RQ1S@1236|Gammaproteobacteria,464Q7@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.135	ko:K21575	-	-	-	-	ko00000,ko01000	-	GH13	-	Alpha-amylase,Cyc-maltodext_C,Cyc-maltodext_N
k59_344828_1	1463934.JOCF01000043_gene120	1.31e-05	52.4	COG4106@1|root,COG4106@2|Bacteria,2I2Y5@201174|Actinobacteria	201174|Actinobacteria	S	O-Methyltransferase	-	-	-	ko:K14251	ko00253,ko01057,ko01130,map00253,map01057,map01130	M00780,M00823	R09189	RC00003,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Dimerisation2,Methyltransf_2
k59_1457417_1	118163.Ple7327_2136	1.79e-63	218.0	COG0156@1|root,COG0604@1|root,COG3321@1|root,COG0156@2|Bacteria,COG0604@2|Bacteria,COG3321@2|Bacteria,1FZXE@1117|Cyanobacteria,3VM40@52604|Pleurocapsales	1117|Cyanobacteria	CHQ	aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2,AMP-binding,Acyl_transf_1,Aminotran_1_2,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
k59_344838_1	861299.J421_3747	1.59e-06	55.5	COG1197@1|root,COG1197@2|Bacteria,1ZT88@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_1679320_1	926569.ANT_15860	1.9e-35	140.0	COG1807@1|root,COG5427@1|root,COG1807@2|Bacteria,COG5427@2|Bacteria,2G5UJ@200795|Chloroflexi	200795|Chloroflexi	M	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2298,PMT_2,TPR_16,TPR_19,TPR_8
k59_901661_1	96561.Dole_1777	1.27e-26	109.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2MPSH@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Sigma-54 interaction domain	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_901661_2	85643.Tmz1t_2260	0.000284	44.3	COG0642@1|root,COG2205@2|Bacteria,1MUAK@1224|Proteobacteria,2VJ6W@28216|Betaproteobacteria,2KUEB@206389|Rhodocyclales	206389|Rhodocyclales	T	Periplasmic domain of Sensor histidine kinase RisS	-	-	2.7.13.3	ko:K07638	ko02020,ko02026,map02020,map02026	M00445,M00742,M00743	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,RisS_PPD
k59_122476_1	751945.Theos_1608	7.67e-23	92.8	COG2332@1|root,COG2332@2|Bacteria,1WJVR@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	O	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH	ccmE	-	-	ko:K02197	-	-	-	-	ko00000	-	-	-	CcmE
k59_122476_2	1123487.KB892857_gene2396	4.02e-18	88.2	COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,2VHUE@28216|Betaproteobacteria,2KUNW@206389|Rhodocyclales	206389|Rhodocyclales	O	Cytochrome c	ccmF	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
k59_400794_1	1122135.KB893138_gene1149	1.49e-66	214.0	COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,2TQSN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Serine-pyruvate aminotransferase archaeal aspartate aminotransferase	phnW	-	2.6.1.37	ko:K03430	ko00440,ko01100,ko01120,map00440,map01100,map01120	-	R04152	RC00008,RC00062	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_5
k59_344844_1	882083.SacmaDRAFT_2728	2.04e-36	134.0	COG1131@1|root,COG1131@2|Bacteria,2IBJD@201174|Actinobacteria,4E1YQ@85010|Pseudonocardiales	201174|Actinobacteria	V	ABC-type multidrug transport system, ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
k59_344844_2	981369.JQMJ01000004_gene450	0.000886	43.1	COG0842@1|root,COG0842@2|Bacteria,2IART@201174|Actinobacteria,2NGAA@228398|Streptacidiphilus	201174|Actinobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_3
k59_1290180_2	1094508.Tsac_1498	0.000152	43.5	COG0285@1|root,COG0285@2|Bacteria,1TPX5@1239|Firmicutes,247PC@186801|Clostridia,42EM6@68295|Thermoanaerobacterales	186801|Clostridia	H	Belongs to the folylpolyglutamate synthase family	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
k59_845164_1	911045.PSE_p0174	9.09e-68	213.0	COG1335@1|root,COG1335@2|Bacteria,1N48X@1224|Proteobacteria,2U17G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG1335 Amidases related to nicotinamidase	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
k59_1512648_1	999541.bgla_1g07700	1.07e-18	87.4	COG0596@1|root,COG0596@2|Bacteria,1MWVN@1224|Proteobacteria,2VM0R@28216|Betaproteobacteria,1JZY1@119060|Burkholderiaceae	28216|Betaproteobacteria	S	epoxide hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	EHN
k59_1067945_2	1123239.KB898630_gene2517	1.78e-20	92.4	COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,4HB3V@91061|Bacilli	91061|Bacilli	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_289771_1	1219084.AP014508_gene778	4.29e-44	157.0	COG0438@1|root,COG0438@2|Bacteria,2GC8Z@200918|Thermotogae	200918|Thermotogae	M	PFAM glycosyl transferase group 1	-	-	2.4.1.245	ko:K13057	ko00500,ko01100,map00500,map01100	-	R08946,R10525,R11306	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000	-	GT4	-	Glycos_transf_1
k59_916558_2	861299.J421_3353	4.89e-21	89.4	COG0319@1|root,COG0319@2|Bacteria,1ZTUP@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	UPF0054
k59_748311_1	1380394.JADL01000007_gene4550	1.15e-52	177.0	COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,2TT2C@28211|Alphaproteobacteria,2JQ4V@204441|Rhodospirillales	204441|Rhodospirillales	FP	exopolyphosphatase	-	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
k59_414728_1	1121013.P873_12705	6.51e-16	82.8	COG2911@1|root,COG2911@2|Bacteria,1MW9V@1224|Proteobacteria,1S3FX@1236|Gammaproteobacteria,1X466@135614|Xanthomonadales	135614|Xanthomonadales	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1193105_1	671143.DAMO_0003	1.7e-68	215.0	COG0785@1|root,COG0785@2|Bacteria,2NPE4@2323|unclassified Bacteria	2|Bacteria	O	Cytochrome C biogenesis protein transmembrane region	ccdA	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	DsbD
k59_1138142_1	945713.IALB_1631	4.4e-104	318.0	COG1008@1|root,COG1008@2|Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoM2	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
k59_81038_1	644282.Deba_1084	3.15e-33	127.0	COG0490@1|root,COG1226@1|root,COG0490@2|Bacteria,COG1226@2|Bacteria,1MU1R@1224|Proteobacteria,42MW6@68525|delta/epsilon subdivisions,2WIYU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Ion transport 2 domain protein	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2,TrkA_C,TrkA_N
k59_1694036_1	1129794.C427_2477	8.75e-48	166.0	COG3677@1|root,COG3677@2|Bacteria,1MXYX@1224|Proteobacteria,1SZQR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	ISXO2-like transposase domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1595,Zn_Tnp_IS1595
k59_471564_1	1236959.BAMT01000002_gene2165	1.15e-19	84.3	COG3339@1|root,COG3339@2|Bacteria,1MZCY@1224|Proteobacteria,2VV31@28216|Betaproteobacteria,2KN8M@206350|Nitrosomonadales	206350|Nitrosomonadales	P	Protein of unknown function (DUF1232)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1232
k59_916600_2	419610.Mext_2996	8.05e-07	56.2	COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2TRC2@28211|Alphaproteobacteria,1JSC4@119045|Methylobacteriaceae	28211|Alphaproteobacteria	I	Carbamoyl-phosphate synthetase large chain domain protein	pccA	GO:0003674,GO:0003824,GO:0004658,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009374,GO:0009987,GO:0016421,GO:0016874,GO:0016885,GO:0017144,GO:0019752,GO:0019842,GO:0019899,GO:0031406,GO:0031974,GO:0032787,GO:0033218,GO:0033293,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0070013,GO:0071704,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901681	6.4.1.3	ko:K01965	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
k59_916600_3	1385512.N784_03050	1.31e-07	52.8	COG4799@1|root,COG4799@2|Bacteria,1TQCV@1239|Firmicutes,4HC50@91061|Bacilli,2Y9JT@289201|Pontibacillus	91061|Bacilli	I	Methylmalonyl-CoA carboxyltransferase	yqjD	GO:0003674,GO:0003824,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016421,GO:0016874,GO:0016885,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0071704,GO:0072329,GO:1901575	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_971330_1	1469613.JT55_09840	3.47e-22	100.0	COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,2TQV5@28211|Alphaproteobacteria,3FCT4@34008|Rhodovulum	28211|Alphaproteobacteria	S	Tetratricopeptide repeat	MA20_42300	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_2,TPR_6,TPR_7,TPR_8
k59_971330_2	1547437.LL06_02620	1.2e-09	58.5	COG1947@1|root,COG1947@2|Bacteria,1MVU3@1224|Proteobacteria,2TUFV@28211|Alphaproteobacteria,43HJ9@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	I	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
k59_471576_1	1173029.JH980292_gene3913	1.06e-60	205.0	COG1816@1|root,COG1816@2|Bacteria,1GAME@1117|Cyanobacteria	1117|Cyanobacteria	F	PFAM Adenosine AMP deaminase	-	-	3.5.4.4	ko:K01488,ko:K19572	ko00230,ko01100,ko05340,map00230,map01100,map05340	-	R01560,R02556	RC00477	ko00000,ko00001,ko01000	-	-	-	A_deaminase
k59_1193145_1	196490.AUEZ01000002_gene4255	2.27e-43	159.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,3JR8W@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,TPR_16,TPR_8
k59_1526521_2	458639.A7KV42_9CAUD	8.03e-22	89.0	4QB3B@10239|Viruses,4QW5R@35237|dsDNA viruses  no RNA stage,4QPXE@28883|Caudovirales,4QHW8@10662|Myoviridae	10662|Myoviridae	S	Bacterial DNA-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_525959_1	1444711.CCJF01000004_gene2369	1.79e-51	185.0	COG3291@1|root,COG3391@1|root,COG3291@2|Bacteria,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Calx-beta,SBBP
k59_1636653_1	926569.ANT_07860	1.18e-71	229.0	COG1316@1|root,COG1316@2|Bacteria	2|Bacteria	K	TRANSCRIPTIONal	-	-	-	-	-	-	-	-	-	-	-	-	LytR_C,LytR_cpsA_psr
k59_916633_1	485913.Krac_0876	2.98e-38	134.0	COG5646@1|root,COG5646@2|Bacteria,2G6Q8@200795|Chloroflexi	200795|Chloroflexi	S	InterPro IPR014922	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
k59_916633_2	913325.N799_13835	1.7e-05	46.6	COG4430@1|root,COG4430@2|Bacteria,1N8ME@1224|Proteobacteria,1T0U8@1236|Gammaproteobacteria,1XD1S@135614|Xanthomonadales	135614|Xanthomonadales	S	Domain of unknown function (DUF1905)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1905,OmdA
k59_358683_1	1127673.GLIP_3893	2.06e-07	52.8	COG3000@1|root,COG3000@2|Bacteria,1PK2S@1224|Proteobacteria,1S338@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	COG3000 Sterol desaturase	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
k59_358683_2	1123070.KB899250_gene449	3.15e-22	94.4	292BJ@1|root,2ZPW1@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_858251_1	926569.ANT_11800	1.38e-54	195.0	COG2203@1|root,COG3850@1|root,COG2203@2|Bacteria,COG3850@2|Bacteria	2|Bacteria	T	phosphorelay sensor kinase activity	-	-	2.7.13.3	ko:K07638,ko:K07673,ko:K21009	ko02020,ko02025,ko02026,map02020,map02025,map02026	M00445,M00471,M00742,M00743	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	AAA_16,GAF,GAF_2,GGDEF,HAMP,HATPase_c,HD,HisKA,PAS_3,PAS_9,PilJ,Pkinase,Response_reg,SpoIIE
k59_1526541_1	1304275.C41B8_07447	2.28e-53	186.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,1RQ7D@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	asparagine synthase, glutamine-hydrolyzing	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
k59_25729_1	926569.ANT_06740	1.58e-50	174.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	ko:K08217	-	-	-	-	br01600,ko00000,ko01504,ko02000	2.A.1.21.1,2.A.1.21.22	-	-	MFS_1
k59_1471520_1	386415.NT01CX_0550	1.34e-31	123.0	COG3872@1|root,COG3872@2|Bacteria,1TPBU@1239|Firmicutes,25C8E@186801|Clostridia,36FM3@31979|Clostridiaceae	186801|Clostridia	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	-	-	-	-	-	-	-	-	-	-	-	DUF1385,MTS
k59_136265_1	338969.Rfer_2205	2.99e-22	97.1	COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,2VJ6H@28216|Betaproteobacteria,4AA48@80864|Comamonadaceae	28216|Betaproteobacteria	F	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor	pyrD	-	1.3.5.2	ko:K00254	ko00240,ko01100,map00240,map01100	M00051	R01868	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
k59_136265_2	1187851.A33M_2210	3.53e-27	102.0	2CAZC@1|root,32ZW8@2|Bacteria,1N86F@1224|Proteobacteria,2UGV9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	MA20_22075	-	-	-	-	-	-	-	-	-	-	-	-
k59_1415340_2	1403313.AXBR01000019_gene3368	1.3e-17	82.8	COG1053@1|root,COG1053@2|Bacteria,1TPAR@1239|Firmicutes,4HAXN@91061|Bacilli,1ZBU7@1386|Bacillus	91061|Bacilli	C	COG1053 Succinate dehydrogenase fumarate reductase, flavoprotein subunit	-	-	-	ko:K13796	-	-	-	-	ko00000	-	-	-	FAD_binding_2
k59_1193189_2	1565129.JSFF01000002_gene3476	2.5e-18	83.2	COG0500@1|root,COG2226@2|Bacteria,1QVT4@1224|Proteobacteria,1T2P6@1236|Gammaproteobacteria,2QC0S@267890|Shewanellaceae	1236|Gammaproteobacteria	Q	Methyltransferase type 12	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23,Methyltransf_25,TehB
k59_414817_1	867903.ThesuDRAFT_00246	2.93e-46	162.0	COG0020@1|root,COG0020@2|Bacteria,1TQTS@1239|Firmicutes,247TE@186801|Clostridia,3WD1H@538999|Clostridiales incertae sedis	186801|Clostridia	H	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
k59_695238_1	1144310.PMI07_005586	6.35e-94	297.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TVI3@28211|Alphaproteobacteria,4BCQJ@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	-	-	-	-	-	-	-	-	-	TctA,TctB
k59_805732_1	296591.Bpro_1824	6.36e-105	308.0	COG3485@1|root,COG3485@2|Bacteria	2|Bacteria	Q	protocatechuate 3,4-dioxygenase activity	catA	-	1.13.11.1	ko:K03381	ko00361,ko00362,ko00364,ko00623,ko01100,ko01120,ko01220,map00361,map00362,map00364,map00623,map01100,map01120,map01220	M00568	R00817,R04258,R05299,R08114,R08115,R09134	RC00388,RC00535,RC01366	ko00000,ko00001,ko00002,ko01000	-	-	-	Dioxygenase_C
k59_249345_1	472759.Nhal_3586	9.46e-98	306.0	COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,1RN7H@1236|Gammaproteobacteria,1X0IX@135613|Chromatiales	135613|Chromatiales	S	PFAM peptidase S15	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
k59_193880_1	331869.BAL199_24954	6.11e-30	113.0	COG4149@1|root,COG4149@2|Bacteria,1MUXR@1224|Proteobacteria,2TSYJ@28211|Alphaproteobacteria,4BQHT@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	modB	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	BPD_transp_1
k59_193880_2	1378168.N510_00222	1.66e-15	77.0	COG3842@1|root,COG3842@2|Bacteria,1TQ18@1239|Firmicutes	1239|Firmicutes	E	ABC transporter	modC	-	3.6.3.29	ko:K02017	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran
k59_1749975_1	489825.LYNGBM3L_09370	5.57e-94	283.0	COG2877@1|root,COG2877@2|Bacteria,1G2XI@1117|Cyanobacteria,1HE3V@1150|Oscillatoriales	1117|Cyanobacteria	M	DAHP synthetase I family	kdsA	-	2.5.1.55	ko:K01627	ko00540,ko01100,map00540,map01100	M00063	R03254	RC00435	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	DAHP_synth_1
k59_582492_1	648757.Rvan_0993	9.2e-24	107.0	COG2211@1|root,COG2211@2|Bacteria,1QZ99@1224|Proteobacteria,2TZ09@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	BT1 family	-	-	-	ko:K08226	-	-	-	-	ko00000,ko02000	2.A.1.41	-	-	PUCC
k59_582492_2	246194.CHY_0481	4.58e-14	72.0	COG1232@1|root,COG1232@2|Bacteria,1TQ6W@1239|Firmicutes,24IHQ@186801|Clostridia	186801|Clostridia	H	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX	-	-	1.3.3.15,1.3.3.4	ko:K00231	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03222,R04178	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
k59_1083788_1	1416752.AYME01000004_gene2137	5.48e-59	192.0	COG1250@1|root,COG1250@2|Bacteria,2GJBM@201174|Actinobacteria,4FM25@85023|Microbacteriaceae	201174|Actinobacteria	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	paaH	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
k59_1584081_1	215803.DB30_1542	9.51e-77	247.0	COG0427@1|root,COG1670@1|root,COG0427@2|Bacteria,COG1670@2|Bacteria,1MUGE@1224|Proteobacteria,42MHC@68525|delta/epsilon subdivisions,2WINZ@28221|Deltaproteobacteria,2YW0C@29|Myxococcales	28221|Deltaproteobacteria	C	Acetyl-CoA hydrolase/transferase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro,Acetyltransf_1
k59_1029576_1	1333998.M2A_0627	3.51e-87	273.0	COG0019@1|root,COG0019@2|Bacteria,1MZ7Y@1224|Proteobacteria,2TSKB@28211|Alphaproteobacteria,4BP9T@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Pyridoxal-dependent decarboxylase, pyridoxal binding domain	ldc	-	4.1.1.17	ko:K01581	ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130	M00134	R00670	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
k59_582509_1	1229780.BN381_90114	1.37e-74	234.0	COG1732@1|root,COG1732@2|Bacteria,2GJWY@201174|Actinobacteria,3UXCV@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	M	Substrate binding domain of ABC-type glycine betaine transport system	-	-	-	ko:K05845	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	OpuAC
k59_860013_1	591157.SSLG_00163	6.92e-128	374.0	COG4638@1|root,COG4638@2|Bacteria,2HJQP@201174|Actinobacteria	201174|Actinobacteria	P	Rieske [2Fe-2S] domain	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
k59_1083804_1	1346791.M529_19325	1.92e-26	112.0	COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,2TR1W@28211|Alphaproteobacteria,2JZYK@204457|Sphingomonadales	204457|Sphingomonadales	FP	exopolyphosphatase	-	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
k59_1584086_1	526225.Gobs_3780	6.51e-19	87.8	COG0579@1|root,COG0579@2|Bacteria,2GKFB@201174|Actinobacteria,4ETP5@85013|Frankiales	201174|Actinobacteria	S	FAD dependent oxidoreductase	-	-	-	ko:K15736	-	-	-	-	ko00000,ko01000	-	-	-	DAO,NAD_binding_8
k59_1584086_2	1397278.AYMV01000030_gene2465	1.87e-05	48.5	COG2084@1|root,COG2084@2|Bacteria,2GNB0@201174|Actinobacteria,4FNG4@85023|Microbacteriaceae	201174|Actinobacteria	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	1.1.1.31,1.1.1.60	ko:K00020,ko:K00042	ko00280,ko00630,ko01100,map00280,map00630,map01100	-	R01745,R01747,R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
k59_137974_1	391038.Bphy_4692	1.9e-22	94.0	COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,2VH1U@28216|Betaproteobacteria,1K1FH@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
k59_637954_1	1382306.JNIM01000001_gene3845	1.07e-71	233.0	COG0138@1|root,COG0138@2|Bacteria,2G5JG@200795|Chloroflexi	200795|Chloroflexi	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
k59_1306547_1	323261.Noc_0909	5.72e-31	122.0	COG2377@1|root,COG2377@2|Bacteria,1MV4E@1224|Proteobacteria,1RNTZ@1236|Gammaproteobacteria,1WXXP@135613|Chromatiales	135613|Chromatiales	O	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling	anmK	-	2.7.1.170	ko:K09001	-	-	-	-	ko00000,ko01000	-	-	-	AnmK
k59_695278_1	671143.DAMO_1990	2.6e-54	185.0	COG1207@1|root,COG1207@2|Bacteria,2NNPC@2323|unclassified Bacteria	2|Bacteria	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	GO:0000270,GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0003977,GO:0005488,GO:0005975,GO:0005976,GO:0006022,GO:0006023,GO:0006024,GO:0006629,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009252,GO:0009273,GO:0009987,GO:0016051,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0019134,GO:0022610,GO:0030203,GO:0030260,GO:0033692,GO:0034637,GO:0034645,GO:0035635,GO:0040007,GO:0042546,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044403,GO:0044406,GO:0044409,GO:0044419,GO:0044650,GO:0046872,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0070569,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1903509	2.3.1.157,2.7.7.23	ko:K04042,ko:K11528,ko:K16203	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000,ko01002	3.A.1.5.2	-	iJN678.glmU,iLJ478.TM1629	Hexapep,NTP_transf_3,NTP_transferase
k59_1417075_1	565045.NOR51B_794	5.87e-23	93.6	COG3577@1|root,COG3577@2|Bacteria,1N2PE@1224|Proteobacteria,1S60F@1236|Gammaproteobacteria,1J6M3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	aspartyl protease	orf	-	-	ko:K06985	ko04112,map04112	-	-	-	ko00000,ko00001	-	-	-	gag-asp_proteas
k59_1417075_2	399739.Pmen_0778	2.31e-33	123.0	COG0157@1|root,COG0157@2|Bacteria,1MW0C@1224|Proteobacteria,1RMBU@1236|Gammaproteobacteria,1YEWU@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	H	Belongs to the NadC ModD family	nadC	GO:0003674,GO:0003824,GO:0004514,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016054,GO:0016740,GO:0016757,GO:0016763,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034213,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0042737,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046483,GO:0046496,GO:0046700,GO:0046874,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0072526,GO:0090407,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	iECP_1309.ECP_0109	QRPTase_C,QRPTase_N
k59_1528293_1	247490.KSU1_A0077	1.08e-28	112.0	COG3259@1|root,COG3259@2|Bacteria,2IYS2@203682|Planctomycetes	203682|Planctomycetes	C	Nickel-dependent hydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NiFeSe_Hases
k59_1528293_2	518766.Rmar_2589	9.45e-44	149.0	COG1941@1|root,COG1941@2|Bacteria	2|Bacteria	C	coenzyme F420 hydrogenase activity	hoxY	-	-	-	-	-	-	-	-	-	-	-	Oxidored_q6
k59_1252207_1	1499967.BAYZ01000073_gene2044	7.39e-28	110.0	COG3383@1|root,COG3383@2|Bacteria	2|Bacteria	C	formate dehydrogenase (NAD+) activity	-	-	1.17.1.10	ko:K05299	ko00680,ko00720,ko01100,ko01120,ko01200,map00680,map00720,map01100,map01120,map01200	M00377	R00134	RC02796	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_4,Fer4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_1252207_2	555088.DealDRAFT_1821	3.99e-09	57.4	COG3383@1|root,COG3383@2|Bacteria,1TT6D@1239|Firmicutes,24YN9@186801|Clostridia,42JP3@68298|Syntrophomonadaceae	186801|Clostridia	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	fdhA	-	1.17.1.10,1.17.1.9	ko:K00123,ko:K05299	ko00630,ko00680,ko00720,ko01100,ko01120,ko01200,map00630,map00680,map00720,map01100,map01120,map01200	M00377	R00134,R00519	RC02796	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_4,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_193936_1	1245469.S58_30890	1.37e-36	136.0	COG1142@1|root,COG1142@2|Bacteria,1RIXA@1224|Proteobacteria,2UDYU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1638437_1	1211115.ALIQ01000179_gene1561	5.21e-23	102.0	COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,2TS5N@28211|Alphaproteobacteria,3N9RE@45404|Beijerinckiaceae	28211|Alphaproteobacteria	C	2-oxoacid dehydrogenases acyltransferase (catalytic domain)	sucB	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_249406_1	331869.BAL199_23804	6.75e-55	181.0	COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,2TRHP@28211|Alphaproteobacteria,4BP7V@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	F	Belongs to the ATCase OTCase family	pyrB	GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_1638459_1	860228.Ccan_14040	7.51e-09	58.9	COG0702@1|root,COG0702@2|Bacteria,4NHAI@976|Bacteroidetes,1I15G@117743|Flavobacteriia,1ERFB@1016|Capnocytophaga	976|Bacteroidetes	GM	Pfam:SusD	-	-	-	ko:K21572	-	-	-	-	ko00000,ko02000	8.A.46.1,8.A.46.3	-	-	SusD-like_3,SusD_RagB
k59_1638459_2	420662.Mpe_A1703	1.62e-09	57.8	COG0288@1|root,COG0288@2|Bacteria,1NGFN@1224|Proteobacteria,2VR34@28216|Betaproteobacteria,1KMBY@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Reversible hydration of carbon dioxide	cynT	GO:0003674,GO:0003824,GO:0004089,GO:0005488,GO:0008150,GO:0008270,GO:0015976,GO:0016829,GO:0016835,GO:0016836,GO:0043167,GO:0043169,GO:0046872,GO:0046914	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
k59_1361906_1	675635.Psed_0787	9.23e-06	52.0	COG0265@1|root,COG0265@2|Bacteria,2GJ96@201174|Actinobacteria,4DXXX@85010|Pseudonocardiales	201174|Actinobacteria	O	PDZ domain (Also known as DHR or GLGF)	pepD	-	-	ko:K08372	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Trypsin_2
k59_1361906_2	1267535.KB906767_gene1497	1.04e-16	80.1	COG2120@1|root,COG2120@2|Bacteria,3Y3NP@57723|Acidobacteria,2JIEH@204432|Acidobacteriia	204432|Acidobacteriia	S	GlcNAc-PI de-N-acetylase	-	-	-	ko:K01463	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
k59_473674_1	448385.sce8247	1.17e-16	80.9	COG1309@1|root,COG1309@2|Bacteria,1N45Z@1224|Proteobacteria,432D4@68525|delta/epsilon subdivisions,2WYS6@28221|Deltaproteobacteria,2Z0GQ@29|Myxococcales	28221|Deltaproteobacteria	K	Bacterial transcriptional repressor C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_11,TetR_N
k59_360555_1	1125700.HMPREF9195_01791	1.4e-21	95.1	COG0749@1|root,COG0749@2|Bacteria,2J5FM@203691|Spirochaetes	203691|Spirochaetes	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_360555_2	986075.CathTA2_1906	4.33e-28	105.0	COG1247@1|root,COG1247@2|Bacteria,1V6X5@1239|Firmicutes,4HGYP@91061|Bacilli	91061|Bacilli	M	Sortase and related acyltransferases	pat	-	2.3.1.183	ko:K03823	ko00440,ko01130,map00440,map01130	-	R08871,R08938	RC00004,RC00064	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_4
k59_305847_1	319236.JCM19294_591	2.46e-43	154.0	COG2195@1|root,COG2195@2|Bacteria,4NG8I@976|Bacteroidetes,1HWUA@117743|Flavobacteriia,3HJKR@363408|Nonlabens	976|Bacteroidetes	E	Peptidase dimerisation domain	pepD	-	-	ko:K01270	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
k59_1696040_1	1408224.SAMCCGM7_c2350	2.91e-23	100.0	COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,2VF65@28211|Alphaproteobacteria,4BBA2@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Transposase for insertion sequence element	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_416604_1	292564.Cyagr_2675	9.21e-61	210.0	COG3119@1|root,COG3119@2|Bacteria,1G22U@1117|Cyanobacteria,22RRC@167375|Cyanobium	1117|Cyanobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_27536_1	886293.Sinac_2348	1.52e-100	310.0	COG0365@1|root,COG0365@2|Bacteria,2IX5P@203682|Planctomycetes	203682|Planctomycetes	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_305858_1	329726.AM1_2178	4.54e-51	182.0	COG0842@1|root,COG1131@1|root,COG1716@1|root,COG0842@2|Bacteria,COG1131@2|Bacteria,COG1716@2|Bacteria,1G102@1117|Cyanobacteria	1117|Cyanobacteria	V	ABC-type multidrug transport system ATPase component	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane,ABC_tran,FHA
k59_360568_1	926569.ANT_13790	6.54e-123	362.0	COG0055@1|root,COG0055@2|Bacteria,2G5JI@200795|Chloroflexi	200795|Chloroflexi	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_1541727_1	1125863.JAFN01000001_gene2235	7.85e-07	48.1	COG3462@1|root,COG3462@2|Bacteria	2|Bacteria	S	membrane protein (DUF2078)	-	-	-	ko:K08982	-	-	-	-	ko00000	-	-	-	SHOCT
k59_430731_1	204669.Acid345_3500	4.97e-37	146.0	COG0577@1|root,COG0577@2|Bacteria,3Y402@57723|Acidobacteria,2JP1F@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_1599217_1	1385518.N798_01200	2.18e-63	208.0	COG1835@1|root,COG1835@2|Bacteria,2GN56@201174|Actinobacteria,4FFV2@85021|Intrasporangiaceae	201174|Actinobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
k59_321280_1	1267003.KB911407_gene945	0.000788	44.3	COG0595@1|root,COG0595@2|Bacteria,1TQ9G@1239|Firmicutes,4HAAP@91061|Bacilli,3F3U9@33958|Lactobacillaceae	91061|Bacilli	J	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay	rnjB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016787,GO:0016788,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,RMMBL
k59_710327_2	234267.Acid_5296	6.18e-90	273.0	COG4447@1|root,COG4447@2|Bacteria,3Y3TM@57723|Acidobacteria	57723|Acidobacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR
k59_1711593_1	1267003.KB911406_gene1468	1.98e-45	155.0	COG0702@1|root,COG0702@2|Bacteria,1UJSC@1239|Firmicutes,4HCVT@91061|Bacilli,3F4ZZ@33958|Lactobacillaceae	91061|Bacilli	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10
k59_1711593_2	99598.Cal7507_5544	1.02e-38	139.0	COG0667@1|root,COG0667@2|Bacteria,1G3GW@1117|Cyanobacteria,1HMUJ@1161|Nostocales	1117|Cyanobacteria	C	PFAM aldo keto reductase	-	-	1.1.1.65	ko:K05275	ko00750,ko01100,ko01120,map00750,map01100,map01120	-	R01708	RC00116	ko00000,ko00001,ko01000	-	-	-	Aldo_ket_red
k59_262942_1	1443665.JACA01000056_gene3206	4.67e-11	68.6	COG0823@1|root,COG1228@1|root,COG0823@2|Bacteria,COG1228@2|Bacteria,4PM8I@976|Bacteroidetes,1HZ2Z@117743|Flavobacteriia,2YIU9@290174|Aquimarina	976|Bacteroidetes	QU	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,PD40
k59_321310_1	1279009.ADICEAN_01324	1.67e-44	155.0	COG1131@1|root,COG1131@2|Bacteria,4NEH0@976|Bacteroidetes,47KF6@768503|Cytophagia	976|Bacteroidetes	V	TIGRFAM Gliding motility-associated ABC transporter ATP-binding subunit GldA	gldA	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_875206_1	1379270.AUXF01000002_gene1585	4.71e-55	195.0	COG0515@1|root,COG0515@2|Bacteria,1ZUMJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
k59_1541765_1	518766.Rmar_2129	8.68e-104	314.0	COG0334@1|root,COG0334@2|Bacteria,4NEBH@976|Bacteroidetes,1FIWI@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	C	Belongs to the Glu Leu Phe Val dehydrogenases family	gdhA	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
k59_1322292_1	255470.cbdbA722	1.17e-23	102.0	COG0634@1|root,COG1102@1|root,COG2203@1|root,COG0634@2|Bacteria,COG1102@2|Bacteria,COG2203@2|Bacteria,2G6HX@200795|Chloroflexi,34D91@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Phosphoribosyl transferase domain	-	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	GAF_2,Pribosyltran
k59_1322292_2	1122622.ATWJ01000010_gene1191	1.39e-05	45.8	COG1259@1|root,COG1259@2|Bacteria,2GN26@201174|Actinobacteria,4FGHI@85021|Intrasporangiaceae	201174|Actinobacteria	S	Bifunctional nuclease	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase
k59_764100_1	316274.Haur_1014	2.94e-09	62.4	COG1309@1|root,COG1309@2|Bacteria,2G9J8@200795|Chloroflexi,3760Y@32061|Chloroflexia	32061|Chloroflexia	K	PFAM regulatory protein TetR	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_1599293_1	1463854.JOHT01000018_gene3899	3.93e-05	51.2	COG0500@1|root,COG2230@1|root,COG2226@2|Bacteria,COG2230@2|Bacteria,2IAU4@201174|Actinobacteria	201174|Actinobacteria	M	methyltransferase	-	-	2.1.1.156,2.1.1.157	ko:K18896,ko:K18897	ko00260,map00260	-	R10060,R10061	RC00003,RC03038,RC03040	ko00000,ko00001,ko01000	-	-	-	Methyltransf_11,Methyltransf_25
k59_710370_1	498761.HM1_1355	1.23e-79	253.0	COG0008@1|root,COG0008@2|Bacteria,1TPJC@1239|Firmicutes,2482P@186801|Clostridia	186801|Clostridia	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.24	ko:K09698	ko00970,ko01100,map00970,map01100	M00360	R03651,R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c
k59_1045121_1	1453501.JELR01000001_gene2934	3.38e-96	296.0	COG4805@1|root,COG4805@2|Bacteria,1MZDR@1224|Proteobacteria,1RZK8@1236|Gammaproteobacteria,465YN@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1599300_2	861299.J421_0308	5.5e-39	136.0	COG1595@1|root,COG1595@2|Bacteria,1ZTP3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_1154518_1	279714.FuraDRAFT_0669	2.56e-81	268.0	COG1038@1|root,COG1038@2|Bacteria,1NW9R@1224|Proteobacteria,2VI52@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second	pyc	-	6.4.1.1	ko:K01958	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,HMGL-like,PYC_OADA
k59_262981_1	1247963.JPHU01000011_gene829	3.86e-23	95.1	COG2885@1|root,COG2885@2|Bacteria,1MYBP@1224|Proteobacteria,2U787@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Belongs to the ompA family	yiaD	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_Omp,Gly-zipper_YMGG,OmpA
k59_764120_1	765913.ThidrDRAFT_3974	2.48e-45	162.0	COG3213@1|root,COG3213@2|Bacteria,1MUJK@1224|Proteobacteria,1RMCR@1236|Gammaproteobacteria,1WXCQ@135613|Chromatiales	135613|Chromatiales	P	PFAM NnrS family protein	-	-	-	ko:K07234	-	-	-	-	ko00000	-	-	-	NnrS
k59_1322323_1	1122929.KB908224_gene3538	6.06e-21	92.4	COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,2TRDA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	2.7.1.71,4.2.3.4	ko:K01735,ko:K13829	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R03083	RC00002,RC00078,RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase,SKI
k59_1322323_2	1122132.AQYH01000007_gene2222	7.92e-26	102.0	COG0703@1|root,COG0703@2|Bacteria,1MUFJ@1224|Proteobacteria,2U76C@28211|Alphaproteobacteria,4BMI3@82115|Rhizobiaceae	28211|Alphaproteobacteria	F	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
k59_543260_2	1417296.U879_06615	4.19e-40	147.0	COG0053@1|root,COG0053@2|Bacteria,1PXF4@1224|Proteobacteria,2TV0K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
k59_1210471_1	1123401.JHYQ01000002_gene2630	1.38e-09	62.4	COG0546@1|root,COG0546@2|Bacteria,1RCXJ@1224|Proteobacteria,1S3VU@1236|Gammaproteobacteria,460UI@72273|Thiotrichales	72273|Thiotrichales	S	PFAM Haloacid dehalogenase-like hydrolase	-	-	3.1.3.105	ko:K22292	ko00520,map00520	-	R11785	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
k59_821423_1	977880.RALTA_B1366	2.56e-62	212.0	COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,2VGZZ@28216|Betaproteobacteria,1K0ZA@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48,Glyco_hydro_77
k59_1210472_1	1463887.KL589983_gene5255	0.000117	48.9	COG1309@1|root,COG1309@2|Bacteria,2HG87@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_1210474_1	926569.ANT_29920	6.24e-83	270.0	COG3383@1|root,COG3383@2|Bacteria,2GBH3@200795|Chloroflexi	200795|Chloroflexi	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_264092_1	1297742.A176_05990	2.42e-14	76.3	COG4784@1|root,COG4784@2|Bacteria,1QTT7@1224|Proteobacteria,43C89@68525|delta/epsilon subdivisions,2X7IN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
k59_1542829_1	570967.JMLV01000012_gene3209	7.3e-70	223.0	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,2TSGS@28211|Alphaproteobacteria,2JQEM@204441|Rhodospirillales	204441|Rhodospirillales	Q	Permease MlaE	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE,STAS_2
k59_1600457_2	1121413.JMKT01000009_gene2094	1.14e-30	120.0	COG1488@1|root,COG1488@2|Bacteria,1R5W0@1224|Proteobacteria,42NQQ@68525|delta/epsilon subdivisions,2WJ4V@28221|Deltaproteobacteria,2MB2B@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	-	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	NAPRTase,QRPTase_C
k59_322667_1	1379698.RBG1_1C00001G0109	6.67e-50	168.0	COG1108@1|root,COG1108@2|Bacteria,2NQ6F@2323|unclassified Bacteria	2|Bacteria	U	ABC 3 transport family	znuB	-	-	ko:K02075,ko:K09816	ko02010,map02010	M00242,M00244	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15,3.A.1.15.3,3.A.1.15.5	-	-	ABC-3
k59_98781_1	926551.KB900730_gene1714	8.05e-23	92.8	2DNPH@1|root,32YF1@2|Bacteria,4NVUP@976|Bacteroidetes,1IIC9@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1653425_1	421531.IX38_00325	4.67e-07	56.6	COG4198@1|root,COG4198@2|Bacteria,4NI11@976|Bacteroidetes,1HY2D@117743|Flavobacteriia,3ZQGA@59732|Chryseobacterium	976|Bacteroidetes	S	Starch-binding associating with outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	SusD-like
k59_1653431_2	234267.Acid_0372	6.61e-21	92.4	COG3104@1|root,COG3104@2|Bacteria,3Y6W5@57723|Acidobacteria	57723|Acidobacteria	E	POT family	-	-	-	ko:K03305	-	-	-	-	ko00000	2.A.17	-	-	PTR2
k59_98796_1	290397.Adeh_0430	9.84e-66	211.0	COG1801@1|root,COG1801@2|Bacteria,1N4QE@1224|Proteobacteria,42PDW@68525|delta/epsilon subdivisions,2WK6H@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
k59_1323672_1	1379270.AUXF01000001_gene2742	5.86e-69	232.0	COG2866@1|root,COG2866@2|Bacteria,1ZSMP@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Zinc carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
k59_98801_1	1462527.CCDM010000002_gene790	4.01e-10	59.7	COG0352@1|root,COG0352@2|Bacteria,1V6KJ@1239|Firmicutes,4HIM9@91061|Bacilli	91061|Bacilli	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	tenI	-	2.5.1.3,5.3.99.10	ko:K00788,ko:K10810	ko00730,ko01100,map00730,map01100	M00127	R03223,R09977,R10712	RC00224,RC02766,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000,ko03000	-	-	-	TMP-TENI
k59_98801_2	1123267.JONN01000001_gene1588	1.02e-17	76.6	COG2022@1|root,COG2022@2|Bacteria,1QYPA@1224|Proteobacteria,2TXU5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	ThiS family	-	-	-	-	-	-	-	-	-	-	-	-	ThiS
k59_1100116_2	1432055.GLUCORHAEAF1_08735	1.73e-29	119.0	COG2379@1|root,COG2379@2|Bacteria,1MVIK@1224|Proteobacteria,2TQJY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Hydroxypyruvate reductase	ttuD	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
k59_207927_1	1121428.DESHY_70037___1	2.81e-89	277.0	COG0154@1|root,COG0154@2|Bacteria,1TP0C@1239|Firmicutes,24911@186801|Clostridia,2613E@186807|Peptococcaceae	186801|Clostridia	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
k59_1489805_1	977880.RALTA_A1087	5.92e-48	169.0	COG1250@1|root,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2VK75@28216|Betaproteobacteria,1K1T0@119060|Burkholderiaceae	28216|Betaproteobacteria	I	3-hydroxyacyl-CoA dehydrogenase	paaH	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
k59_876634_1	861299.J421_4207	1.66e-37	144.0	COG0612@1|root,COG0612@2|Bacteria,1ZSU0@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Insulinase (Peptidase family M16)	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_42282_1	1211579.PP4_51530	4.11e-22	96.3	COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,1RPZ7@1236|Gammaproteobacteria,1YWBP@136845|Pseudomonas putida group	1236|Gammaproteobacteria	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006276,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0010332,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042221,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0046677,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
k59_42282_2	323848.Nmul_A0702	3.63e-70	214.0	COG1981@1|root,COG1981@2|Bacteria,1RHGS@1224|Proteobacteria,2VR5Y@28216|Betaproteobacteria,3737C@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Uncharacterised protein family (UPF0093)	-	-	-	ko:K08973	-	-	-	-	ko00000	-	-	-	UPF0093
k59_322731_1	1379270.AUXF01000004_gene3140	7.37e-59	196.0	COG4324@1|root,COG4324@2|Bacteria,1ZT8G@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Putative aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Aminopep
k59_1210557_1	1396141.BATP01000032_gene4415	8.17e-74	248.0	COG2273@1|root,COG2931@1|root,COG5492@1|root,COG2273@2|Bacteria,COG2931@2|Bacteria,COG5492@2|Bacteria,46UXF@74201|Verrucomicrobia,2IV2T@203494|Verrucomicrobiae	203494|Verrucomicrobiae	GN	Domain of unknown function (DUF5060)	-	-	-	-	-	-	-	-	-	-	-	-	Collagen_bind_2,DUF5060
k59_490035_1	309803.CTN_0256	3.44e-74	232.0	COG1402@1|root,COG1402@2|Bacteria	2|Bacteria	I	creatininase	-	-	3.5.2.10	ko:K01470,ko:K22232	ko00330,ko00562,map00330,map00562	-	R01884,R11771	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
k59_711840_2	1122962.AULH01000022_gene2906	3.53e-31	119.0	COG0395@1|root,COG0395@2|Bacteria,1MUMG@1224|Proteobacteria,2TVBP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	ABC-type sugar transport system, permease component	aglG	-	-	ko:K10234	ko02010,map02010	M00201	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.32,3.A.1.1.8	-	-	BPD_transp_1
k59_598226_1	671143.DAMO_1028	6.12e-97	290.0	COG0031@1|root,COG0031@2|Bacteria,2NP1M@2323|unclassified Bacteria	2|Bacteria	E	Pyridoxal-phosphate dependent enzyme	cysM	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0032991,GO:0033847,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0080146,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.113,2.5.1.47,6.1.1.16	ko:K01883,ko:K12339,ko:K21148	ko00270,ko00920,ko00970,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04122,map00270,map00920,map00970,map01100,map01110,map01120,map01130,map01200,map01230,map04122	M00021,M00359,M00360	R00897,R03132,R03601,R03650,R04859,R10610	RC00020,RC00055,RC00523,RC02814,RC02821,RC02876,RC03225	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	PALP,tRNA-synt_1e
k59_1653513_1	477184.KYC_28477	8.61e-38	137.0	COG0596@1|root,COG0596@2|Bacteria,1MVVX@1224|Proteobacteria,2WGX8@28216|Betaproteobacteria,3T6EN@506|Alcaligenaceae	28216|Betaproteobacteria	S	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
k59_153894_2	1230457.C476_08073	5.81e-10	59.3	arCOG10140@1|root,arCOG10140@2157|Archaea,2XYX2@28890|Euryarchaeota,23X2V@183963|Halobacteria	183963|Halobacteria	S	Ethyl tert-butyl ether degradation EthD	-	-	-	-	-	-	-	-	-	-	-	-	EthD,MmlI
k59_1600543_1	414684.RC1_1608	1.67e-86	279.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,2USBB@28211|Alphaproteobacteria,2JQFN@204441|Rhodospirillales	204441|Rhodospirillales	M	penicillin-binding protein 1A	mrcA	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	PCB_OB,Transgly,Transpeptidase
k59_322768_1	685035.ADAE01000007_gene1401	8.33e-31	121.0	COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria,2TST5@28211|Alphaproteobacteria,2K5FS@204457|Sphingomonadales	204457|Sphingomonadales	P	Sodium/calcium exchanger protein	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
k59_1600552_1	234267.Acid_6081	1.68e-48	168.0	COG3292@1|root,COG3292@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_3,HATPase_c,PKD_3,Reg_prop
k59_652735_1	926569.ANT_14340	8.89e-70	231.0	COG1480@1|root,COG1480@2|Bacteria,2G5WC@200795|Chloroflexi	200795|Chloroflexi	S	metal-dependent phosphohydrolase, HD sub domain	-	-	-	ko:K07037	-	-	-	-	ko00000	-	-	-	7TM-7TMR_HD,7TMR-HDED,HD
k59_990107_1	861299.J421_3134	6.16e-24	106.0	COG4206@1|root,COG4206@2|Bacteria	2|Bacteria	H	cobalamin-transporting ATPase activity	btuB	-	-	ko:K02014,ko:K16092	-	-	-	-	ko00000,ko02000	1.B.14,1.B.14.3	-	-	Plug,TonB_dep_Rec
k59_711897_1	671143.DAMO_2945	2.18e-105	330.0	COG0188@1|root,COG0188@2|Bacteria,2NNNR@2323|unclassified Bacteria	2|Bacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_1210610_1	398527.Bphyt_6657	2.9e-69	219.0	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,2VHUC@28216|Betaproteobacteria,1K4YM@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
k59_821565_1	746697.Aeqsu_2695	6.58e-06	48.9	COG2815@1|root,COG2815@2|Bacteria,4NXFG@976|Bacteroidetes,1I6HM@117743|Flavobacteriia	976|Bacteroidetes	S	TIR domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	TIR_2
k59_98902_1	983545.Glaag_0023	5.86e-14	68.6	COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,1S247@1236|Gammaproteobacteria,466J1@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008270,GO:0008463,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043021,GO:0043022,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046872,GO:0046914,GO:0071704,GO:1901564	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
k59_98902_2	998674.ATTE01000001_gene502	1.15e-28	112.0	COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,1RP1T@1236|Gammaproteobacteria,45ZQR@72273|Thiotrichales	72273|Thiotrichales	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
k59_153947_1	441620.Mpop_5127	1.95e-23	103.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,1JTNU@119045|Methylobacteriaceae	28211|Alphaproteobacteria	V	Hydrophobe Amphiphile Efflux-1 (HAE1) Family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_1046383_1	251221.35214685	1.55e-37	136.0	COG1064@1|root,COG1064@2|Bacteria,1G0B9@1117|Cyanobacteria	1117|Cyanobacteria	C	alcohol dehydrogenase	-	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_1765042_1	713586.KB900536_gene1821	6.97e-59	192.0	COG0500@1|root,COG2226@2|Bacteria,1PA5F@1224|Proteobacteria,1RY7A@1236|Gammaproteobacteria,1WW45@135613|Chromatiales	135613|Chromatiales	H	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway	bioC	-	2.1.1.197	ko:K02169	ko00780,ko01100,map00780,map01100	M00572	R09543	RC00003,RC00460	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11
k59_781336_1	316274.Haur_1217	6.21e-43	159.0	COG0642@1|root,COG2202@1|root,COG3290@1|root,COG3829@1|root,COG3850@1|root,COG5002@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,COG3290@2|Bacteria,COG3829@2|Bacteria,COG3850@2|Bacteria,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	2.7.13.3,4.6.1.1	ko:K01768,ko:K11527,ko:K18143	ko00230,ko01501,ko02025,ko04113,ko04213,map00230,map01501,map02025,map04113,map04213	M00649,M00655,M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022	-	-	-	CHASE,GAF,GGDEF,HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
k59_725874_2	1353531.AZNX01000005_gene3546	1.55e-171	485.0	2C1EG@1|root,2Z7MZ@2|Bacteria,1NQTP@1224|Proteobacteria,2UPDR@28211|Alphaproteobacteria,4BAAM@82115|Rhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1670858_2	867903.ThesuDRAFT_02020	1.22e-77	236.0	COG2080@1|root,COG2080@2|Bacteria,1V6HE@1239|Firmicutes,24HQN@186801|Clostridia	186801|Clostridia	C	aerobic-type carbon monoxide dehydrogenase, small subunit CoxS	hcrC	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
k59_169817_1	1273125.Rrhod_4294	2.63e-30	123.0	COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria,4FV5G@85025|Nocardiaceae	201174|Actinobacteria	C	Dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_169817_2	1051632.TPY_2012	4.5e-25	106.0	COG1529@1|root,COG2080@1|root,COG1529@2|Bacteria,COG2080@2|Bacteria,1TP7U@1239|Firmicutes,248BV@186801|Clostridia,3WD5H@538999|Clostridiales incertae sedis	186801|Clostridia	C	Aldehyde oxidase and xanthine dehydrogenase, a b hammerhead domain	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2
k59_1615160_1	861299.J421_0584	4.66e-73	239.0	COG0308@1|root,COG0308@2|Bacteria,1ZT68@142182|Gemmatimonadetes	2|Bacteria	E	aminopeptidase N	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
k59_781354_2	671143.DAMO_1694	1.42e-05	46.6	COG1225@1|root,COG1225@2|Bacteria	2|Bacteria	O	peroxiredoxin activity	-	-	1.11.1.15	ko:K03386,ko:K03564,ko:K16922	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04147	-	-	-	AhpC-TSA,Redoxin
k59_670232_1	864069.MicloDRAFT_00054840	5.24e-63	197.0	COG0625@1|root,COG0625@2|Bacteria,1RA05@1224|Proteobacteria,2TS58@28211|Alphaproteobacteria,1JR35@119045|Methylobacteriaceae	28211|Alphaproteobacteria	O	PFAM Glutathione S-transferase domain	gstch8	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_N,GST_N_3
k59_1003807_1	404589.Anae109_0267	6.57e-42	151.0	COG2264@1|root,COG2264@2|Bacteria,1MUPC@1224|Proteobacteria,42NSS@68525|delta/epsilon subdivisions,2WIVV@28221|Deltaproteobacteria,2Z2ZT@29|Myxococcales	28221|Deltaproteobacteria	J	Methylates ribosomal protein L11	prmA	-	-	ko:K02687	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PrmA
k59_1226397_1	1167006.UWK_02578	9.99e-60	199.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,42NES@68525|delta/epsilon subdivisions,2WJ0V@28221|Deltaproteobacteria,2MHWD@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	type II secretion system	pilC	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
k59_1226397_2	903818.KI912268_gene3151	2.31e-39	142.0	COG2805@1|root,COG2805@2|Bacteria,3Y316@57723|Acidobacteria	57723|Acidobacteria	NU	Type II/IV secretion system protein	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
k59_615677_1	1459636.NTE_02046	3.18e-53	182.0	COG0381@1|root,arCOG01392@2157|Archaea	2157|Archaea	M	UDP-N-acetylglucosamine 2-epimerase	-	-	5.1.3.14	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase_2
k59_671451_1	1121104.AQXH01000003_gene329	4.84e-43	162.0	COG5276@1|root,COG5276@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,DUF1566,LVIVD,Pec_lyase_C,Pectinesterase
k59_1227720_1	203122.Sde_0930	2.15e-93	292.0	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,1RNNJ@1236|Gammaproteobacteria,464WS@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA2	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_1227733_1	246196.MSMEI_1061	3.43e-20	90.9	COG0831@1|root,COG0832@1|root,COG0831@2|Bacteria,COG0832@2|Bacteria,2IKNA@201174|Actinobacteria,23F15@1762|Mycobacteriaceae	201174|Actinobacteria	E	COG0831 Urea amidohydrolase (urease) gamma subunit	ureAB	-	3.5.1.5	ko:K14048	ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120	-	R00131	RC02798,RC02806	ko00000,ko00001,ko01000	-	-	-	Urease_beta,Urease_gamma
k59_1727610_1	454957.IA64_08105	2.14e-47	172.0	COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,1RSNV@1236|Gammaproteobacteria,1X46E@135614|Xanthomonadales	135614|Xanthomonadales	L	Helicase	lhr1	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
k59_1449877_1	225937.HP15_3273	2.14e-12	64.3	COG1309@1|root,COG1309@2|Bacteria,1MWF7@1224|Proteobacteria,1RPZ6@1236|Gammaproteobacteria,465HE@72275|Alteromonadaceae	1236|Gammaproteobacteria	D	Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions	slmA	GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0000918,GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0007049,GO:0007346,GO:0008150,GO:0009295,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0010564,GO:0010948,GO:0010974,GO:0016043,GO:0019219,GO:0019222,GO:0022402,GO:0022607,GO:0031323,GO:0031326,GO:0031333,GO:0032271,GO:0032272,GO:0032465,GO:0032466,GO:0032506,GO:0032954,GO:0032955,GO:0042802,GO:0043085,GO:0043087,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043254,GO:0043547,GO:0043565,GO:0043590,GO:0044085,GO:0044087,GO:0044093,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0045786,GO:0045930,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051252,GO:0051301,GO:0051302,GO:0051336,GO:0051345,GO:0051726,GO:0051782,GO:0060255,GO:0061640,GO:0065007,GO:0065009,GO:0071840,GO:0080090,GO:0090529,GO:0097159,GO:0140110,GO:1901363,GO:1901891,GO:1901892,GO:1902410,GO:1902412,GO:1902413,GO:1903047,GO:1903436,GO:1903437,GO:1903506,GO:1990837,GO:2000112,GO:2001141	-	ko:K05501	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	TetR_N
k59_1449877_2	1288826.MSNKSG1_12432	1.24e-65	206.0	COG2022@1|root,COG2022@2|Bacteria,1N0N5@1224|Proteobacteria,1RMPD@1236|Gammaproteobacteria,465GP@72275|Alteromonadaceae	1236|Gammaproteobacteria	H	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S	thiG	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.8.1.10	ko:K03149	ko00730,ko01100,map00730,map01100	-	R10247	RC03096,RC03097,RC03461	ko00000,ko00001,ko01000	-	-	iECABU_c1320.ECABU_c45060,iECO26_1355.ECO26_5099,ic_1306.c4947	ThiG
k59_1060449_1	1286631.X805_37300	1.17e-56	182.0	COG3023@1|root,COG3023@2|Bacteria,1RDHU@1224|Proteobacteria,2VR5A@28216|Betaproteobacteria,1KKNN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	V	Negative regulator of	ampD	GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008745,GO:0009056,GO:0009057,GO:0009253,GO:0009254,GO:0009392,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0019867,GO:0030203,GO:0043167,GO:0043169,GO:0043170,GO:0046872,GO:0046914,GO:0061783,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575	3.5.1.28	ko:K03806	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	Amidase_2
k59_1060449_2	395494.Galf_0370	2.89e-27	110.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,44VDT@713636|Nitrosomonadales	28216|Betaproteobacteria	T	PFAM sigma-54 factor interaction domain-containing protein	pilR	-	-	ko:K02667	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_671488_1	77635.BISU_0662	6.17e-05	42.0	29W73@1|root,30HSA@2|Bacteria,2IRUV@201174|Actinobacteria,4D19P@85004|Bifidobacteriales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_671488_2	1296416.JACB01000019_gene4878	9.9e-09	56.6	2CIH2@1|root,2ZTG0@2|Bacteria,4NV9G@976|Bacteroidetes,1I6EU@117743|Flavobacteriia	976|Bacteroidetes	S	Putative lumazine-binding	-	-	-	-	-	-	-	-	-	-	-	-	Lumazine_bd_2
k59_393425_1	1144275.COCOR_00079	4.44e-79	263.0	COG0823@1|root,COG1228@1|root,COG0823@2|Bacteria,COG1228@2|Bacteria,1MX3A@1224|Proteobacteria,438QJ@68525|delta/epsilon subdivisions,2X3XW@28221|Deltaproteobacteria,2YXIE@29|Myxococcales	28221|Deltaproteobacteria	QU	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,PD40
k59_1060467_2	457398.HMPREF0326_02891	1.8e-20	86.3	COG3542@1|root,COG3542@2|Bacteria,1RHBE@1224|Proteobacteria,42T2P@68525|delta/epsilon subdivisions,2WPQ3@28221|Deltaproteobacteria,2MBSS@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Cupin superfamily (DUF985)	-	-	-	ko:K09705	-	-	-	-	ko00000	-	-	-	Cupin_5
k59_559996_1	1120950.KB892767_gene5139	3.81e-39	149.0	COG0110@1|root,COG0663@1|root,COG1020@1|root,COG0110@2|Bacteria,COG0663@2|Bacteria,COG1020@2|Bacteria,2I8TI@201174|Actinobacteria,4DNE5@85009|Propionibacteriales	201174|Actinobacteria	Q	Phosphopantetheine attachment site	nrps4	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Hexapep,Hexapep_2,PP-binding
k59_1116384_1	1190603.AJYD01000026_gene3336	8.93e-77	249.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,1RMQB@1236|Gammaproteobacteria,1XUNK@135623|Vibrionales	135623|Vibrionales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctA
k59_838059_1	926569.ANT_04500	3.55e-95	286.0	COG0674@1|root,COG0674@2|Bacteria,2G5UG@200795|Chloroflexi	200795|Chloroflexi	C	Pyruvate:ferredoxin oxidoreductase core domain II	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
k59_727168_1	574087.Acear_2351	1.4e-20	92.0	COG0706@1|root,COG0706@2|Bacteria,1TQ0J@1239|Firmicutes,247V9@186801|Clostridia,3WAP9@53433|Halanaerobiales	186801|Clostridia	U	TIGRFAM membrane protein insertase, YidC Oxa1 family	oxaA	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP
k59_1282970_2	247156.NFA_46610	2.05e-09	60.1	COG2084@1|root,COG2084@2|Bacteria,2GNI7@201174|Actinobacteria,4FVG5@85025|Nocardiaceae	201174|Actinobacteria	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	1.1.1.31,1.1.1.60	ko:K00020,ko:K00042	ko00280,ko00630,ko01100,map00280,map00630,map01100	-	R01745,R01747,R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
k59_949457_1	700508.D174_07195	5.02e-11	64.7	COG3193@1|root,COG3193@2|Bacteria,2IHWI@201174|Actinobacteria,239G4@1762|Mycobacteriaceae	201174|Actinobacteria	S	Haem-degrading	-	-	-	-	-	-	-	-	-	-	-	-	Haem_degrading
k59_226699_1	1449126.JQKL01000020_gene3350	1.97e-19	93.6	COG1167@1|root,COG1167@2|Bacteria,1TPS5@1239|Firmicutes,248ZB@186801|Clostridia,26947@186813|unclassified Clostridiales	186801|Clostridia	EK	Psort location Cytoplasmic, score	-	-	-	ko:K05825	ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210	-	R01939	RC00006	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2
k59_560026_1	935845.JADQ01000010_gene2983	3.28e-09	62.0	COG0619@1|root,COG0619@2|Bacteria,1TPMV@1239|Firmicutes,4HBTW@91061|Bacilli,26T8A@186822|Paenibacillaceae	91061|Bacilli	P	ABC-type cobalt transport system, permease component CbiQ	cbiQ	-	-	ko:K16785	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	CbiQ
k59_1616401_1	1232446.BAIE02000047_gene374	1.86e-37	136.0	COG1125@1|root,COG1125@2|Bacteria,1TPV8@1239|Firmicutes,248YZ@186801|Clostridia	186801|Clostridia	E	glycine betaine L-proline	-	-	-	ko:K05847	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	ABC_tran
k59_171098_1	926569.ANT_30110	2.72e-33	125.0	COG0860@1|root,COG0860@2|Bacteria,2G7IE@200795|Chloroflexi	200795|Chloroflexi	M	PFAM cell wall hydrolase autolysin	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3
k59_1560884_1	1254432.SCE1572_35300	6.11e-51	177.0	COG3930@1|root,COG3930@2|Bacteria,1PYFH@1224|Proteobacteria,42ZAK@68525|delta/epsilon subdivisions,2WUH8@28221|Deltaproteobacteria,2YUXI@29|Myxococcales	28221|Deltaproteobacteria	S	DUF1704	-	-	-	-	-	-	-	-	-	-	-	-	DUF1704,FGase
k59_1060505_1	1120933.ATUY01000001_gene786	1.31e-44	163.0	COG0358@1|root,COG0358@2|Bacteria,2GJFX@201174|Actinobacteria,4D4GH@85005|Actinomycetales	201174|Actinobacteria	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,DnaG_DnaB_bind,Toprim_4,Toprim_N,zf-CHC2
k59_1116419_1	1094508.Tsac_0382	3.87e-63	212.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,42F44@68295|Thermoanaerobacterales	186801|Clostridia	V	ABC transporter, transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_504779_2	926569.ANT_30110	8.6e-74	230.0	COG0860@1|root,COG0860@2|Bacteria,2G7IE@200795|Chloroflexi	200795|Chloroflexi	M	PFAM cell wall hydrolase autolysin	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3
k59_782636_1	383372.Rcas_2666	9.14e-79	248.0	COG1879@1|root,COG1879@2|Bacteria,2G8QP@200795|Chloroflexi	200795|Chloroflexi	P	Periplasmic binding protein domain	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
k59_893997_1	379066.GAU_3308	5.38e-45	160.0	COG2234@1|root,COG2234@2|Bacteria,1ZTDG@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
k59_782638_1	987059.RBXJA2T_11917	1.22e-56	186.0	COG1218@1|root,COG1218@2|Bacteria,1N0GY@1224|Proteobacteria,2VJWH@28216|Betaproteobacteria	28216|Betaproteobacteria	P	3'(2'),5'-bisphosphate nucleotidase	cysQ	-	3.1.3.7	ko:K01082	ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	Inositol_P
k59_393510_1	1169152.AXVD01000031_gene2212	9.86e-28	111.0	COG3173@1|root,COG3173@2|Bacteria,2GJT0@201174|Actinobacteria,4FUKX@85025|Nocardiaceae	201174|Actinobacteria	S	Aminoglycoside phosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	APH
k59_226747_1	526225.Gobs_1069	5.17e-35	135.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,2GMN4@201174|Actinobacteria,4ES6Q@85013|Frankiales	201174|Actinobacteria	GT	PEP-utilising enzyme, mobile domain	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
k59_1283032_1	1120973.AQXL01000124_gene2325	4.92e-73	236.0	COG1175@1|root,COG1175@2|Bacteria,1TTAF@1239|Firmicutes,4HBIM@91061|Bacilli,2790R@186823|Alicyclobacillaceae	91061|Bacilli	G	Binding-protein-dependent transport system inner membrane component	sugA_2	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
k59_4527_1	888808.HMPREF9380_0299	2.09e-11	66.6	COG1577@1|root,COG1577@2|Bacteria,1TPVW@1239|Firmicutes,4IRCB@91061|Bacilli,1WQME@1305|Streptococcus sanguinis	91061|Bacilli	I	Mevalonate kinase	mvk	-	2.7.1.36	ko:K00869	ko00900,ko01100,ko01110,ko01130,ko04146,map00900,map01100,map01110,map01130,map04146	M00095	R02245	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
k59_504808_1	338963.Pcar_0537	1.3e-38	131.0	COG2963@1|root,COG2963@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_28,HTH_Tnp_1
k59_1449976_1	864702.OsccyDRAFT_4322	9.55e-92	279.0	COG3385@1|root,COG3385@2|Bacteria,1G7HA@1117|Cyanobacteria,1HHM3@1150|Oscillatoriales	1117|Cyanobacteria	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5,DDE_Tnp_1
k59_671593_1	671143.DAMO_0495	4.23e-43	144.0	COG0848@1|root,COG0848@2|Bacteria,2NQ52@2323|unclassified Bacteria	2|Bacteria	U	Biopolymer transport protein ExbD/TolR	tolR	-	-	ko:K03559,ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.1,1.A.30.2.2	-	-	ExbD
k59_671593_2	671143.DAMO_0494	1.87e-20	87.8	COG0811@1|root,COG0811@2|Bacteria,2NPFR@2323|unclassified Bacteria	2|Bacteria	U	MotA/TolQ/ExbB proton channel family	tolQ	-	-	ko:K03561,ko:K03562	ko01120,map01120	-	-	-	ko00000,ko02000	1.A.30.2.1,1.A.30.2.2	-	-	MotA_ExbB
k59_282452_1	545276.KB898727_gene305	7.07e-57	193.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,1MUDN@1224|Proteobacteria,1RMMG@1236|Gammaproteobacteria,1WXIJ@135613|Chromatiales	135613|Chromatiales	P	Metallo-beta-lactamase superfamily	-	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B,Rhodanese
k59_1505268_1	1123501.KB902313_gene2835	3.68e-06	53.9	COG3214@1|root,COG3214@2|Bacteria,1N40B@1224|Proteobacteria,2TT7U@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein conserved in bacteria	-	-	-	ko:K09927	-	-	-	-	ko00000	-	-	-	HTH_42
k59_727255_1	861299.J421_2629	6.15e-149	431.0	COG0055@1|root,COG0055@2|Bacteria,1ZSNP@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_1116470_1	335543.Sfum_1389	1.47e-38	137.0	COG1811@1|root,COG1811@2|Bacteria,1MX1D@1224|Proteobacteria,42S9G@68525|delta/epsilon subdivisions,2WNUQ@28221|Deltaproteobacteria,2MQH1@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF554)	-	-	-	ko:K07150	-	-	-	-	ko00000	-	-	-	DUF554
k59_393537_1	1403819.BATR01000184_gene6389	2.87e-70	219.0	COG0702@1|root,COG0702@2|Bacteria,46UG1@74201|Verrucomicrobia	74201|Verrucomicrobia	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_671613_2	319795.Dgeo_2388	1.52e-45	159.0	COG0599@1|root,COG2267@1|root,COG0599@2|Bacteria,COG2267@2|Bacteria,1WJIG@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	Alpha beta hydrolase	-	-	3.1.1.24,4.1.1.44	ko:K01055,ko:K14727	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00568	R02991,R03470	RC00825,RC00938	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1,CMD
k59_671623_2	56780.SYN_00691	9.76e-25	102.0	COG1013@1|root,COG1013@2|Bacteria,1MUY9@1224|Proteobacteria,42MQY@68525|delta/epsilon subdivisions,2WJGJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Thiamine pyrophosphate	-	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
k59_782691_1	1340493.JNIF01000003_gene4033	1.67e-44	160.0	COG0577@1|root,COG0577@2|Bacteria,3Y3XI@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_727280_1	398580.Dshi_3330	6.02e-91	280.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_337750_1	234267.Acid_4154	2.45e-15	81.6	COG0577@1|root,COG0577@2|Bacteria,3Y3K0@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_1338681_1	1348663.KCH_40980	9.31e-20	91.7	COG1073@1|root,COG1073@2|Bacteria,2IC0U@201174|Actinobacteria,2M4EH@2063|Kitasatospora	201174|Actinobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6,Hydrolase_4
k59_894070_1	1122951.ATUE01000007_gene790	4.88e-23	102.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,1RMAP@1236|Gammaproteobacteria,3NJMK@468|Moraxellaceae	1236|Gammaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
k59_1283089_1	376733.IT41_19950	7.41e-75	238.0	COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,2TTAW@28211|Alphaproteobacteria,2PZC6@265|Paracoccus	28211|Alphaproteobacteria	L	Transposase, Mutator family	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_1227923_1	330214.NIDE0986	1.34e-41	144.0	COG0107@1|root,COG0107@2|Bacteria,3J0GV@40117|Nitrospirae	40117|Nitrospirae	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
k59_1450043_1	1131269.AQVV01000004_gene608	6.07e-94	285.0	COG1932@1|root,COG1932@2|Bacteria	2|Bacteria	E	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	GO:0003674,GO:0003824,GO:0004648,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006520,GO:0006553,GO:0006563,GO:0006564,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009085,GO:0009089,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019752,GO:0019842,GO:0030170,GO:0033359,GO:0034641,GO:0036094,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046394,GO:0046451,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901615,GO:1901617	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iEcE24377_1341.EcE24377A_1004,iPC815.YPO1389,iYL1228.KPN_00935	Aminotran_5
k59_1686298_1	118005.AWNK01000005_gene1729	2e-90	293.0	COG0458@1|root,COG0458@2|Bacteria	2|Bacteria	F	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	carB	GO:0000050,GO:0000166,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016053,GO:0016597,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0071941,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b0033,iBWG_1329.BWG_0031,iECDH10B_1368.ECDH10B_0034,iECDH1ME8569_1439.ECDH1ME8569_0031,iECUMN_1333.ECUMN_0034,iEcDH1_1363.EcDH1_3566,iJN746.PP_4723,iJO1366.b0033,iJR904.b0033,iPC815.YPO0482,iY75_1357.Y75_RS00170,iYL1228.KPN_00041	CPSase_L_D2,CPSase_L_D3,MGS
k59_1243047_1	1117647.M5M_05025	6.52e-74	236.0	COG3930@1|root,COG3930@2|Bacteria,1PYFH@1224|Proteobacteria,1RP1J@1236|Gammaproteobacteria,1J7I5@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	DUF1704	IV02_27630	-	-	-	-	-	-	-	-	-	-	-	DUF1704
k59_296471_1	861299.J421_2768	9.35e-129	406.0	COG0086@1|root,COG0086@2|Bacteria,1ZSZQ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_629303_1	1249627.D779_1480	7.71e-71	234.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RR0R@1236|Gammaproteobacteria,1WWF9@135613|Chromatiales	1236|Gammaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	-	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_1520556_1	314285.KT71_11770	1.67e-59	208.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1J8DZ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	V	Protein export membrane protein	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_1075867_1	1121874.KB892380_gene1745	3.23e-07	52.4	COG0735@1|root,COG0735@2|Bacteria,1VF38@1239|Firmicutes	1239|Firmicutes	P	Belongs to the Fur family	fur	-	-	ko:K02076,ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
k59_1075867_2	383372.Rcas_1591	2.13e-20	91.7	COG0803@1|root,COG0803@2|Bacteria,2G8F6@200795|Chloroflexi,37738@32061|Chloroflexia	32061|Chloroflexia	P	Belongs to the bacterial solute-binding protein 9 family	-	-	-	ko:K02077,ko:K09818	-	M00243,M00244	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ZnuA
k59_130233_1	926569.ANT_05390	1.5e-94	284.0	COG1240@1|root,COG1240@2|Bacteria,2G7UF@200795|Chloroflexi	200795|Chloroflexi	H	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2
k59_1465336_1	1121946.AUAX01000003_gene1554	3.1e-45	157.0	COG0546@1|root,COG0546@2|Bacteria,2GNCU@201174|Actinobacteria,4DC5V@85008|Micromonosporales	201174|Actinobacteria	S	HAD-hyrolase-like	-	-	-	-	-	-	-	-	-	-	-	-	HAD,HAD_2,Hydrolase_like
k59_408967_1	247639.MGP2080_07082	1.87e-54	183.0	COG2008@1|root,COG2008@2|Bacteria,1MWCR@1224|Proteobacteria,1RRGS@1236|Gammaproteobacteria,1J7S9@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde	ltaE	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
k59_408981_1	1267535.KB906767_gene914	9.6e-45	159.0	COG0304@1|root,COG0304@2|Bacteria,3Y43C@57723|Acidobacteria,2JMFI@204432|Acidobacteriia	204432|Acidobacteriia	IQ	Beta-ketoacyl synthase, C-terminal domain	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_1021108_1	1379270.AUXF01000005_gene643	3.64e-48	174.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1ZTF0@142182|Gemmatimonadetes	142182|Gemmatimonadetes	EU	Acetyl xylan esterase (AXE1)	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
k59_75180_1	44056.XP_009036948.1	1.51e-10	69.3	29QRV@1|root,2RX97@2759|Eukaryota	2759|Eukaryota	S	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	REJ,VCBS
k59_186180_1	1120953.AUBH01000001_gene849	3.52e-53	192.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,464AK@72275|Alteromonadaceae	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1465359_1	1417296.U879_09230	2.29e-130	384.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1Q7PK@1224|Proteobacteria,2U20K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Winged helix-turn helix	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_29,HTH_33
k59_1298337_2	1379270.AUXF01000002_gene1846	1.02e-59	206.0	COG1538@1|root,COG1538@2|Bacteria,1ZT9S@142182|Gemmatimonadetes	142182|Gemmatimonadetes	MU	Outer membrane efflux protein	-	-	-	ko:K12340	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	1.B.17,2.A.6.2	-	-	OEP
k59_19935_1	378806.STAUR_5864	6.45e-63	216.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,42M9S@68525|delta/epsilon subdivisions,2WJSZ@28221|Deltaproteobacteria,2YUBF@29|Myxococcales	28221|Deltaproteobacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_465360_1	309801.trd_0193	2.03e-08	60.8	COG2373@1|root,COG2373@2|Bacteria,2GBGP@200795|Chloroflexi,27XNP@189775|Thermomicrobia	189775|Thermomicrobia	M	Prenyltransferase and squalene oxidase repeat	-	-	-	-	-	-	-	-	-	-	-	-	Prenyltrans
k59_130276_1	991905.SL003B_2107	4.36e-113	335.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,2TS63@28211|Alphaproteobacteria,4BPQA@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Citrate synthase, C-terminal domain	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
k59_1687661_1	926560.KE387023_gene2723	3.83e-54	181.0	COG3437@1|root,COG3437@2|Bacteria,1WM50@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	HD domain	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD,Response_reg
k59_1742887_1	1231391.AMZF01000014_gene2433	7.4e-20	88.2	COG0600@1|root,COG0600@2|Bacteria,1MVD2@1224|Proteobacteria,2VI9N@28216|Betaproteobacteria,3T1V6@506|Alcaligenaceae	28216|Betaproteobacteria	P	ABC transporter	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
k59_910312_1	517722.AEUE01000004_gene902	1.05e-43	155.0	COG3239@1|root,COG3239@2|Bacteria,1MVY5@1224|Proteobacteria,2U156@28211|Alphaproteobacteria,2K0CR@204457|Sphingomonadales	204457|Sphingomonadales	I	Fatty acid desaturase	-	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase
k59_1354141_1	504487.JCM19302_2359	1.28e-36	134.0	COG0235@1|root,COG0235@2|Bacteria,4NFRG@976|Bacteroidetes,1I0I4@117743|Flavobacteriia	976|Bacteroidetes	G	Class II Aldolase and Adducin N-terminal domain	-	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
k59_409026_1	485913.Krac_11199	1.96e-97	316.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,2G5Y6@200795|Chloroflexi	200795|Chloroflexi	H	Methionine synthase B12-binding module cap domain protein	-	-	2.1.1.13,2.1.1.258	ko:K00548,ko:K15023	ko00270,ko00450,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01230,map00270,map00450,map00670,map00720,map01100,map01110,map01120,map01200,map01230	M00017,M00377	R00946,R02289,R09365,R10243	RC00004,RC00035,RC00113,RC01144,RC01241,RC02871,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_242163_1	246194.CHY_1926	8.57e-16	75.5	COG0204@1|root,COG0204@2|Bacteria,1U8N2@1239|Firmicutes,25B02@186801|Clostridia,42GFG@68295|Thermoanaerobacterales	186801|Clostridia	I	PFAM Phospholipid glycerol acyltransferase	plsC	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
k59_852748_1	999141.GME_14665	9.23e-107	319.0	COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,1RP95@1236|Gammaproteobacteria,1XHZA@135619|Oceanospirillales	135619|Oceanospirillales	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
k59_742775_1	189753.AXAS01000012_gene4337	1.12e-37	139.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
k59_242168_1	717785.HYPMC_2438	8.7e-34	122.0	COG0355@1|root,COG0355@2|Bacteria,1N0ZB@1224|Proteobacteria,2U9XA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC_2	-	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE_N
k59_242168_2	640512.BC1003_1759	2.85e-37	139.0	COG0055@1|root,COG0055@2|Bacteria,1N6UZ@1224|Proteobacteria,2VI8G@28216|Betaproteobacteria,1K5MG@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD2	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_687582_1	1111069.TCCBUS3UF1_1190	2.11e-09	65.5	COG3385@1|root,COG3385@2|Bacteria,1WJCS@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_297839_1	1205680.CAKO01000030_gene4824	8.73e-09	60.8	COG0583@1|root,COG0583@2|Bacteria,1MV5N@1224|Proteobacteria,2TRAX@28211|Alphaproteobacteria,2JPCC@204441|Rhodospirillales	204441|Rhodospirillales	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_297839_2	1177179.A11A3_00805	3.32e-09	57.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,1RNH8@1236|Gammaproteobacteria,1XIJM@135619|Oceanospirillales	135619|Oceanospirillales	H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis	ubiD	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
k59_1244534_1	658187.LDG_6602	1.12e-73	231.0	COG3220@1|root,COG3220@2|Bacteria,1MURE@1224|Proteobacteria,1RQ9H@1236|Gammaproteobacteria,1JCNU@118969|Legionellales	118969|Legionellales	S	Belongs to the UPF0276 family	-	-	-	ko:K09930	-	-	-	-	ko00000	-	-	-	DUF692
k59_409063_1	1042209.HK44_007320	1.42e-20	89.4	COG0316@1|root,COG2151@1|root,COG0316@2|Bacteria,COG2151@2|Bacteria,1MZ9Y@1224|Proteobacteria,1S36X@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	FeS assembly SUF system protein SufT	sufT	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
k59_409063_2	671143.DAMO_2378	9.49e-27	100.0	COG2151@1|root,COG2151@2|Bacteria,2NPUI@2323|unclassified Bacteria	2|Bacteria	S	Pfam:DUF59	paaD	-	-	ko:K02612	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001	-	-	-	FeS_assembly_P
k59_910370_1	861299.J421_2633	1.08e-41	157.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
k59_1742940_2	1123278.KB893444_gene1710	6.54e-24	102.0	COG0624@1|root,COG0624@2|Bacteria,4NEHJ@976|Bacteroidetes,47MC5@768503|Cytophagia	976|Bacteroidetes	E	Peptidase dimerisation domain	-	-	-	ko:K13049	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
k59_630600_1	1501230.ET33_07070	2.95e-81	248.0	COG2197@1|root,COG2197@2|Bacteria,1VTB2@1239|Firmicutes,4HUXN@91061|Bacilli,274DU@186822|Paenibacillaceae	91061|Bacilli	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_1298433_1	1040986.ATYO01000038_gene1344	3.99e-16	83.2	COG4932@1|root,COG4932@2|Bacteria,1QYHZ@1224|Proteobacteria,2UHT4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Conserved repeat domain	-	-	-	-	-	-	-	-	-	-	-	-	SdrD_B
k59_1576418_1	1122223.KB890687_gene2738	0.000582	47.8	COG3828@1|root,COG3828@2|Bacteria,1WN34@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	FG-GAP repeat	-	-	-	-	-	-	-	-	-	-	-	-	ThuA,VCBS
k59_1298439_1	82654.Pse7367_1527	3.84e-45	164.0	COG0591@1|root,COG0591@2|Bacteria,1G1JV@1117|Cyanobacteria,1H88V@1150|Oscillatoriales	1117|Cyanobacteria	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	putP	-	-	-	-	-	-	-	-	-	-	-	SSF
k59_1576423_1	4081.Solyc02g076720.2.1	1.3e-110	353.0	COG0046@1|root,KOG1907@2759|Eukaryota,37IK9@33090|Viridiplantae,3GFB1@35493|Streptophyta,44G15@71274|asterids	35493|Streptophyta	F	phosphoribosylformylglycinamidine synthase	-	GO:0000166,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0007275,GO:0008144,GO:0008150,GO:0009507,GO:0009532,GO:0009536,GO:0009555,GO:0009570,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0030554,GO:0032501,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0048229,GO:0048856,GO:0055046,GO:0097159,GO:0097367,GO:1901265,GO:1901363	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS_C,GATase_5
k59_1354219_1	1122132.AQYH01000005_gene459	4.49e-22	92.0	COG2834@1|root,COG2834@2|Bacteria,1RA1S@1224|Proteobacteria,2U58W@28211|Alphaproteobacteria,4B8UW@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	lolA	-	-	-	-	-	-	-	-	-	-	-	LolA
k59_1354219_2	1381123.AYOD01000014_gene2347	1.98e-27	106.0	COG0708@1|root,COG0708@2|Bacteria,1MVMC@1224|Proteobacteria,2TRWQ@28211|Alphaproteobacteria,43I5U@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	L	exodeoxyribonuclease III	xthA2	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
k59_1465459_1	33898.JRHJ01000001_gene601	3.76e-54	191.0	COG0542@1|root,COG0542@2|Bacteria,2GJ73@201174|Actinobacteria	201174|Actinobacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695,ko:K03696	ko01100,ko04213,map01100,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_1576443_1	211114.JOEF01000047_gene5458	1.14e-14	77.8	COG0235@1|root,COG0235@2|Bacteria,2GJ8W@201174|Actinobacteria,4E5TS@85010|Pseudonocardiales	201174|Actinobacteria	G	Class II Aldolase and Adducin N-terminal domain	-	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
k59_20053_2	56780.SYN_02506	2.23e-17	82.0	COG5608@1|root,COG5608@2|Bacteria,1Q3JI@1224|Proteobacteria,42XEN@68525|delta/epsilon subdivisions,2WSWH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	SMART Water Stress and Hypersensitive response	-	-	-	-	-	-	-	-	-	-	-	-	LEA_2
k59_297906_1	157783.LK03_20435	4.56e-11	67.0	28MSC@1|root,2ZB0S@2|Bacteria,1NG2A@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_630647_1	78245.Xaut_2625	8.37e-39	142.0	COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,2TRFA@28211|Alphaproteobacteria,3EYXT@335928|Xanthobacteraceae	28211|Alphaproteobacteria	E	Belongs to the aspartokinase family	lysC	GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
k59_630647_2	477974.Daud_0358	7.32e-33	125.0	COG0119@1|root,COG0119@2|Bacteria,1TRIK@1239|Firmicutes,249Q4@186801|Clostridia,25ZY6@186807|Peptococcaceae	186801|Clostridia	E	Belongs to the alpha-IPM synthase homocitrate synthase family	leuA3	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
k59_465494_1	290397.Adeh_0963	8.05e-30	118.0	COG1273@1|root,COG1273@2|Bacteria,1N4UX@1224|Proteobacteria,42RD5@68525|delta/epsilon subdivisions,2WMZ1@28221|Deltaproteobacteria,2YV5B@29|Myxococcales	28221|Deltaproteobacteria	L	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD	ku	-	-	ko:K10979	ko03450,map03450	-	-	-	ko00000,ko00001,ko03400	-	-	-	Ku
k59_742870_1	448385.sce1683	2.85e-20	90.5	COG4221@1|root,COG4221@2|Bacteria,1QVCA@1224|Proteobacteria,431MP@68525|delta/epsilon subdivisions,2WWCC@28221|Deltaproteobacteria,2Z3JH@29|Myxococcales	28221|Deltaproteobacteria	S	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_186334_1	1168059.KB899087_gene2519	1.21e-13	75.9	COG0398@1|root,COG1502@1|root,COG0398@2|Bacteria,COG1502@2|Bacteria,1MV8I@1224|Proteobacteria,2TTM4@28211|Alphaproteobacteria,3F0DU@335928|Xanthobacteraceae	28211|Alphaproteobacteria	I	Phospholipase D Active site motif	-	-	-	-	-	-	-	-	-	-	-	-	PLDc,PLDc_2,SNARE_assoc
k59_409132_1	926569.ANT_14270	7.4e-124	362.0	COG0022@1|root,COG0022@2|Bacteria,2G60F@200795|Chloroflexi	200795|Chloroflexi	C	PFAM Transketolase central region	-	-	1.2.4.1,1.2.4.4	ko:K00162,ko:K11381,ko:K21417	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
k59_1021284_1	867903.ThesuDRAFT_00242	1.71e-76	243.0	COG0821@1|root,COG0821@2|Bacteria,1TPFR@1239|Firmicutes,247N1@186801|Clostridia,3WCC9@538999|Clostridiales incertae sedis	186801|Clostridia	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS06430	GcpE
k59_1631314_1	1123366.TH3_06360	1.33e-46	164.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria,2JQI2@204441|Rhodospirillales	204441|Rhodospirillales	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	-	ko:K18661	ko00280,map00280	-	R03383	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C
k59_965210_1	1123393.KB891333_gene2505	4.04e-101	314.0	COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,2VI3K@28216|Betaproteobacteria,1KSG5@119069|Hydrogenophilales	119069|Hydrogenophilales	C	Inorganic H+ pyrophosphatase	-	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
k59_1743033_1	671143.DAMO_1024	1.02e-92	281.0	COG0476@1|root,COG1977@1|root,COG0476@2|Bacteria,COG1977@2|Bacteria,2NPX3@2323|unclassified Bacteria	2|Bacteria	H	ThiF family	moeB	-	2.7.7.73,2.7.7.80,2.8.1.11	ko:K03148,ko:K03636,ko:K21029,ko:K21147	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	Rhodanese,ThiF,ThiS
k59_75365_1	298654.FraEuI1c_6914	4.42e-42	148.0	COG2267@1|root,COG2267@2|Bacteria,2I94I@201174|Actinobacteria	201174|Actinobacteria	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
k59_1465549_1	981085.XP_010101845.1	1.27e-42	152.0	COG0158@1|root,KOG1458@2759|Eukaryota,37JJU@33090|Viridiplantae,3GECH@35493|Streptophyta,4JFHY@91835|fabids	35493|Streptophyta	G	Belongs to the FBPase class 1 family	FBP	GO:0003674,GO:0003824,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005984,GO:0005985,GO:0005986,GO:0005996,GO:0006000,GO:0006002,GO:0006006,GO:0006091,GO:0006094,GO:0006793,GO:0006796,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009266,GO:0009311,GO:0009312,GO:0009409,GO:0009507,GO:0009526,GO:0009532,GO:0009536,GO:0009570,GO:0009628,GO:0009719,GO:0009725,GO:0009735,GO:0009767,GO:0009773,GO:0009987,GO:0010033,GO:0010319,GO:0015979,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019318,GO:0019319,GO:0019637,GO:0019684,GO:0022900,GO:0030388,GO:0031967,GO:0031975,GO:0034637,GO:0042132,GO:0042221,GO:0042578,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046351,GO:0046364,GO:0048046,GO:0050308,GO:0050896,GO:0055114,GO:0071704,GO:1901135,GO:1901576	3.1.3.11	ko:K03841	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko04152,ko04910,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map04152,map04910	M00003,M00165,M00167,M00344	R00762,R04780	RC00017	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	FBPase
k59_186380_2	700598.Niako_6385	4.72e-70	216.0	COG0252@1|root,COG0252@2|Bacteria,4NRB3@976|Bacteroidetes,1IXAX@117747|Sphingobacteriia	976|Bacteroidetes	EJ	Asparaginase, N-terminal	-	-	3.5.1.1	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	-	R00485	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Asparaginase
k59_1631328_1	1313172.YM304_21320	2.52e-90	270.0	COG1028@1|root,COG1028@2|Bacteria,2GK6C@201174|Actinobacteria,4CN06@84992|Acidimicrobiia	84992|Acidimicrobiia	IQ	KR domain	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_242304_1	402881.Plav_2307	3.55e-38	145.0	COG0457@1|root,COG0457@2|Bacteria,1N0A9@1224|Proteobacteria,2TTMN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_14,TPR_16,TPR_19,TPR_2,TPR_8
k59_1752294_1	1123322.KB904692_gene4466	2.45e-21	97.4	COG5002@1|root,COG5002@2|Bacteria,2GJY7@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	senX3	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009405,GO:0009987,GO:0016020,GO:0016310,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044419,GO:0044464,GO:0046777,GO:0051704,GO:0071704,GO:0071944,GO:1901564	2.7.13.3	ko:K07768	ko02020,map02020	M00443	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
k59_85351_1	1292020.H483_0115390	1.7e-10	63.5	COG4961@1|root,COG4961@2|Bacteria,2IS3K@201174|Actinobacteria	201174|Actinobacteria	U	TadE-like protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
k59_753865_1	1112204.GPOL_c25660	1.03e-24	98.6	COG3576@1|root,COG3576@2|Bacteria,2II3S@201174|Actinobacteria	201174|Actinobacteria	IQ	pyridoxamine 5-phosphate	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
k59_1700376_1	351746.Pput_3705	8.75e-12	68.9	COG0235@1|root,COG0235@2|Bacteria,1MWP9@1224|Proteobacteria,1RXYI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	class II Aldolase	-	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
k59_1034075_1	391038.Bphy_2359	2.59e-150	430.0	COG0604@1|root,COG0604@2|Bacteria,1R8NX@1224|Proteobacteria,2W0KY@28216|Betaproteobacteria,1K4PK@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Alcohol dehydrogenase GroES-like domain	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N_2
k59_141787_1	1034347.CAHJ01000010_gene2212	1.06e-07	57.0	COG3336@1|root,COG3336@2|Bacteria,1TQFK@1239|Firmicutes,4H9WN@91061|Bacilli,1ZBC8@1386|Bacillus	91061|Bacilli	S	cytochrome c oxidase	ctaG	-	-	ko:K02862	-	-	-	-	ko00000	-	-	-	Caa3_CtaG
k59_141787_2	479434.Sthe_1585	2.68e-20	85.9	2EKS3@1|root,33EFV@2|Bacteria,2GBBM@200795|Chloroflexi,27YP9@189775|Thermomicrobia	189775|Thermomicrobia	S	Prokaryotic Cytochrome C oxidase subunit IV	-	-	1.9.3.1	ko:K02277	ko00190,ko01100,map00190,map01100	M00155	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.4	-	-	COX4_pro
k59_1311072_1	1379698.RBG1_1C00001G1850	4.5e-27	109.0	COG0705@1|root,COG0705@2|Bacteria,2NPSK@2323|unclassified Bacteria	2|Bacteria	S	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
k59_420512_1	740709.A10D4_11866	9.55e-39	140.0	COG0531@1|root,COG0531@2|Bacteria,1QVWZ@1224|Proteobacteria,1T2MA@1236|Gammaproteobacteria,2QFQB@267893|Idiomarinaceae	1236|Gammaproteobacteria	E	Amino Acid	ybaT	GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0008150,GO:0009268,GO:0009628,GO:0010035,GO:0010038,GO:0016020,GO:0042221,GO:0044464,GO:0046688,GO:0050896,GO:0071944,GO:0097501,GO:1990169	-	-	-	-	-	-	-	-	-	-	AA_permease_2
k59_531674_1	1121015.N789_06695	2.65e-80	256.0	COG0529@1|root,COG2895@1|root,COG0529@2|Bacteria,COG2895@2|Bacteria,1MX0D@1224|Proteobacteria,1RNWT@1236|Gammaproteobacteria,1XCHJ@135614|Xanthomonadales	135614|Xanthomonadales	P	Adenylylsulphate kinase	-	-	2.7.1.25,2.7.7.4	ko:K00955	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176	R00509,R00529,R04928,R04929	RC00002,RC00078,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase,GTP_EFTU
k59_531680_1	1122138.AQUZ01000049_gene2367	2.78e-91	286.0	COG0520@1|root,COG0520@2|Bacteria,2GP7W@201174|Actinobacteria,4DNX7@85009|Propionibacteriales	201174|Actinobacteria	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
k59_141803_2	395964.KE386496_gene1743	9.23e-05	49.3	COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,2TTBG@28211|Alphaproteobacteria,3N9JI@45404|Beijerinckiaceae	28211|Alphaproteobacteria	P	Voltage gated chloride channel	clc	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,Voltage_CLC
k59_1034109_1	323261.Noc_1323	1.02e-42	154.0	2DBYQ@1|root,32TYF@2|Bacteria,1N2HM@1224|Proteobacteria,1SB6Y@1236|Gammaproteobacteria,1X1T1@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1700434_1	269799.Gmet_0655	2.09e-10	62.4	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,42NC3@68525|delta/epsilon subdivisions,2WIJJ@28221|Deltaproteobacteria,43T8A@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	ABC-2 family transporter protein	ybhR	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
k59_1700434_2	370438.PTH_2804	0.000542	45.4	COG0842@1|root,COG1511@1|root,COG0842@2|Bacteria,COG1511@2|Bacteria,1V061@1239|Firmicutes,24DQ8@186801|Clostridia,26016@186807|Peptococcaceae	186801|Clostridia	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
k59_923140_1	7994.ENSAMXP00000003751	9.42e-45	159.0	COG2220@1|root,KOG3798@2759|Eukaryota,39UP3@33154|Opisthokonta,3BFB2@33208|Metazoa,3CWR9@33213|Bilateria,47ZVI@7711|Chordata,48Z9Y@7742|Vertebrata,49XAP@7898|Actinopterygii	33208|Metazoa	S	N-acyl phosphatidylethanolamine phospholipase D	NAPEPLD	GO:0001523,GO:0001659,GO:0001750,GO:0003674,GO:0003824,GO:0004620,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005635,GO:0005654,GO:0005737,GO:0005768,GO:0005769,GO:0005794,GO:0005829,GO:0005886,GO:0005929,GO:0006066,GO:0006576,GO:0006629,GO:0006644,GO:0006650,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007568,GO:0008081,GO:0008150,GO:0008152,GO:0008270,GO:0009308,GO:0009987,GO:0012505,GO:0016020,GO:0016101,GO:0016298,GO:0016787,GO:0016788,GO:0019637,GO:0031090,GO:0031253,GO:0031347,GO:0031349,GO:0031410,GO:0031967,GO:0031974,GO:0031975,GO:0031981,GO:0031982,GO:0032101,GO:0032103,GO:0032501,GO:0032502,GO:0034308,GO:0034641,GO:0035900,GO:0036477,GO:0042439,GO:0042578,GO:0042592,GO:0042622,GO:0042802,GO:0042995,GO:0043005,GO:0043025,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043603,GO:0044106,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044297,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044441,GO:0044444,GO:0044446,GO:0044459,GO:0044463,GO:0044464,GO:0045595,GO:0045597,GO:0045598,GO:0045600,GO:0046337,GO:0046486,GO:0046872,GO:0046914,GO:0048518,GO:0048519,GO:0048521,GO:0048522,GO:0048583,GO:0048584,GO:0048871,GO:0050727,GO:0050729,GO:0050789,GO:0050793,GO:0050794,GO:0050795,GO:0050896,GO:0051094,GO:0060170,GO:0060259,GO:0065007,GO:0065008,GO:0070013,GO:0070290,GO:0070291,GO:0070292,GO:0071704,GO:0071944,GO:0080134,GO:0090335,GO:0090336,GO:0097458,GO:0097708,GO:0097730,GO:0097731,GO:0097733,GO:0098588,GO:0098590,GO:0120025,GO:0120038,GO:1901564,GO:1901615,GO:1903998,GO:1903999,GO:2000252	3.1.4.54	ko:K13985	ko04723,map04723	-	-	-	ko00000,ko00001,ko01000	-	-	-	Lactamase_B_2
k59_478138_1	861299.J421_3309	5.18e-81	254.0	COG0126@1|root,COG0126@2|Bacteria,1ZT1B@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Phosphoglycerate kinase	pgk	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
k59_699502_1	1380391.JIAS01000015_gene72	5.14e-71	232.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2TSSI@28211|Alphaproteobacteria,2JPQ1@204441|Rhodospirillales	204441|Rhodospirillales	I	COG1022 Long-chain acyl-CoA synthetases (AMP-forming)	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
k59_31261_1	1173028.ANKO01000168_gene4334	1.32e-41	156.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1G1P1@1117|Cyanobacteria,1H8EM@1150|Oscillatoriales	1117|Cyanobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_31263_1	759362.KVU_0405	7.77e-104	317.0	COG0804@1|root,COG0804@2|Bacteria,1MU5P@1224|Proteobacteria,2TSXP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family	ureC	-	3.5.1.5	ko:K01428	ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120	-	R00131	RC02798,RC02806	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1,Urease_alpha
k59_923154_1	1547437.LL06_14890	3.2e-05	45.1	COG4957@1|root,COG4957@2|Bacteria,1RGUW@1224|Proteobacteria,2U99M@28211|Alphaproteobacteria,43JUW@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	K	Transcriptional regulator	rosR	-	-	-	-	-	-	-	-	-	-	-	ROS_MUCR
k59_364528_2	401526.TcarDRAFT_2624	5.36e-17	82.4	COG0726@1|root,COG0726@2|Bacteria,1V2Z7@1239|Firmicutes,4H3BX@909932|Negativicutes	909932|Negativicutes	G	PFAM Polysaccharide deacetylase	-	-	-	ko:K11931	ko02026,map02026	-	-	-	ko00000,ko00001,ko01000	-	-	-	GHL13,Polysacc_deac_1
k59_1034156_1	492774.JQMB01000008_gene71	2.78e-45	157.0	COG5662@1|root,COG5662@2|Bacteria,1MV95@1224|Proteobacteria,2TVRG@28211|Alphaproteobacteria,4B8U9@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
k59_1642140_1	1121403.AUCV01000001_gene864	6.56e-70	230.0	COG4231@1|root,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,42N44@68525|delta/epsilon subdivisions,2WIX6@28221|Deltaproteobacteria,2MMVZ@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA-1	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,Fer4_7,POR_N,TPP_enzyme_C
k59_753992_1	379066.GAU_2809	6.92e-40	141.0	COG0501@1|root,COG0501@2|Bacteria,1ZSNK@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Peptidase family M48	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
k59_86855_1	373994.Riv7116_4087	3.77e-28	118.0	COG0642@1|root,COG0784@1|root,COG2199@1|root,COG2202@1|root,COG2203@1|root,COG3829@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG3706@2|Bacteria,COG3829@2|Bacteria,1G09B@1117|Cyanobacteria,1HJ8D@1161|Nostocales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	2.7.13.3	ko:K11527	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
k59_809931_1	1123366.TH3_00185	2.62e-65	211.0	COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,2TRIG@28211|Alphaproteobacteria,2JP9M@204441|Rhodospirillales	204441|Rhodospirillales	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_1700485_1	1469245.JFBG01000006_gene1588	1.21e-20	88.6	COG5012@1|root,COG5012@2|Bacteria,1QDZ3@1224|Proteobacteria,1RYST@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,B12-binding_2
k59_1700485_2	1123251.ATWM01000009_gene2831	3.37e-41	150.0	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,2GNCW@201174|Actinobacteria,4FENX@85021|Intrasporangiaceae	201174|Actinobacteria	E	Belongs to the GcvT family	-	-	-	-	-	-	-	-	-	-	-	-	DAO,FAO_M,GCV_T,GCV_T_C
k59_1700486_1	1038859.AXAU01000010_gene1766	7.72e-129	371.0	COG3618@1|root,COG3618@2|Bacteria,1R4T9@1224|Proteobacteria,2TRFM@28211|Alphaproteobacteria,3JX2A@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
k59_1588261_2	1957.JODX01000012_gene425	3.03e-15	74.3	COG0809@1|root,COG0809@2|Bacteria,2GN51@201174|Actinobacteria	201174|Actinobacteria	J	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	-	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
k59_1256345_1	1267533.KB906736_gene883	9.52e-33	127.0	COG2215@1|root,COG2215@2|Bacteria,3Y79H@57723|Acidobacteria,2JM3I@204432|Acidobacteriia	204432|Acidobacteriia	S	High-affinity nickel-transport protein	-	-	-	ko:K07241	-	-	-	-	ko00000,ko02000	2.A.52.1	-	-	NicO
k59_1256345_2	28258.KP05_10325	1.51e-07	55.5	COG0735@1|root,COG0735@2|Bacteria,1MZIW@1224|Proteobacteria,1S5ZI@1236|Gammaproteobacteria,1XJKD@135619|Oceanospirillales	135619|Oceanospirillales	K	Belongs to the Fur family	-	-	-	ko:K09823	ko02024,map02024	-	-	-	ko00000,ko00001,ko03000	-	-	-	FUR
k59_1588272_1	717605.Theco_0858	1.16e-52	178.0	COG4214@1|root,COG4214@2|Bacteria,1VU1F@1239|Firmicutes,4HBDM@91061|Bacilli,26T54@186822|Paenibacillaceae	91061|Bacilli	G	Belongs to the binding-protein-dependent transport system permease family	araH	-	-	ko:K10544,ko:K10547	ko02010,map02010	M00215,M00216	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.4,3.A.1.2.5	-	-	BPD_transp_2
k59_1588272_2	593907.Celgi_2313	3.31e-17	81.3	COG1129@1|root,COG1129@2|Bacteria,2GJ3F@201174|Actinobacteria,4F0KB@85016|Cellulomonadaceae	201174|Actinobacteria	G	PFAM ABC transporter related	araG	-	3.6.3.17	ko:K10548	ko02010,map02010	M00216	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.5	-	-	ABC_tran
k59_864102_1	357808.RoseRS_2730	4.09e-99	300.0	COG4806@1|root,COG4806@2|Bacteria,2GAHK@200795|Chloroflexi,37666@32061|Chloroflexia	32061|Chloroflexia	H	Belongs to the rhamnose isomerase family	rhaA	-	5.3.1.14	ko:K01813	ko00051,ko01120,map00051,map01120	-	R02437	RC00434	ko00000,ko00001,ko01000	-	-	-	RhaA
k59_1642188_1	861299.J421_0327	3.99e-88	266.0	COG4117@1|root,COG4117@2|Bacteria,1ZUUH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Prokaryotic cytochrome b561	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
k59_1700528_1	1313172.YM304_38680	5.52e-57	192.0	COG1622@1|root,COG1622@2|Bacteria,2GNXA@201174|Actinobacteria,4CN92@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM
k59_310198_1	1121937.AUHJ01000022_gene1361	6.98e-35	137.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMDS@1236|Gammaproteobacteria,464FV@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs	rne	-	3.1.26.12	ko:K08300	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
k59_1588296_1	338966.Ppro_2167	7.54e-78	241.0	COG2513@1|root,COG2513@2|Bacteria,1N4VT@1224|Proteobacteria,42PWB@68525|delta/epsilon subdivisions,2X5K5@28221|Deltaproteobacteria,43VRB@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Phosphoenolpyruvate phosphomutase	-	-	5.4.2.9	ko:K01841	ko00440,ko01100,ko01120,ko01130,map00440,map01100,map01120,map01130	-	R00661	RC02792	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like,NTP_transf_3,PEP_mutase
k59_586815_1	383372.Rcas_2077	2.39e-109	348.0	COG0366@1|root,COG0366@2|Bacteria,2G7SV@200795|Chloroflexi	200795|Chloroflexi	G	Alpha amylase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase
k59_531801_1	489653.NLA_16350	4.59e-35	128.0	COG0424@1|root,COG0424@2|Bacteria,1RH6H@1224|Proteobacteria,2VQC3@28216|Betaproteobacteria,2KR56@206351|Neisseriales	206351|Neisseriales	D	Maf-like protein	-	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
k59_1588306_1	204669.Acid345_0435	1.08e-35	134.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	moxG	-	-	ko:K00406,ko:K16255	ko00190,ko00680,ko01100,ko01120,ko02020,map00190,map00680,map01100,map01120,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	Cytochrom_C,Cytochrome_CBB3
k59_1642210_1	388051.AUFE01000049_gene3930	1.59e-29	122.0	COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2VKH1@28216|Betaproteobacteria,1JZT2@119060|Burkholderiaceae	28216|Betaproteobacteria	T	adenylyl cyclase class-3 4 guanylyl cyclase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DZR,Guanylate_cyc
k59_1256396_1	489825.LYNGBM3L_65490	3.93e-71	233.0	COG3044@1|root,COG3044@2|Bacteria,1G21U@1117|Cyanobacteria,1H8FT@1150|Oscillatoriales	1117|Cyanobacteria	S	ATPase of the ABC class	-	-	-	-	-	-	-	-	-	-	-	-	ABC_ATPase
k59_810010_1	1333998.M2A_1074	1.74e-107	335.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,2TR4E@28211|Alphaproteobacteria,4BPJT@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_810018_1	395493.BegalDRAFT_2219	6.21e-10	64.3	COG1572@1|root,COG2931@1|root,COG3210@1|root,COG3420@1|root,COG4886@1|root,COG4932@1|root,COG1572@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG3420@2|Bacteria,COG4886@2|Bacteria,COG4932@2|Bacteria,1MXIP@1224|Proteobacteria,1RSAX@1236|Gammaproteobacteria,461F5@72273|Thiotrichales	72273|Thiotrichales	U	Large exoproteins involved in heme utilization or adhesion	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_478270_1	379066.GAU_2666	1.98e-38	145.0	COG0823@1|root,COG1228@1|root,COG0823@2|Bacteria,COG1228@2|Bacteria,1ZUMT@142182|Gemmatimonadetes	142182|Gemmatimonadetes	QU	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,PD40
k59_977887_1	1007105.PT7_2650	3.82e-26	106.0	COG1052@1|root,COG1052@2|Bacteria,1REXX@1224|Proteobacteria	1224|Proteobacteria	C	D-isomer specific 2-hydroxyacid dehydrogenase	serA	-	1.1.1.26,1.1.1.28,1.1.1.29,1.1.1.310,1.1.1.399,1.1.1.95	ko:K00015,ko:K00018,ko:K00058,ko:K03778,ko:K16843	ko00260,ko00270,ko00620,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00620,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00020,M00346	R00704,R00717,R01388,R01513,R05693	RC00031,RC00042,RC00044	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
k59_754107_1	1211777.BN77_0436	2.91e-05	50.8	COG1309@1|root,COG1309@2|Bacteria,1N1Q3@1224|Proteobacteria,2TVF4@28211|Alphaproteobacteria,4BAZX@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	transcriptional regulator	-	-	-	ko:K16137	-	-	-	-	ko00000,ko03000	-	-	-	TetR_N
k59_1588342_1	926569.ANT_20960	1.06e-42	151.0	COG0803@1|root,COG0803@2|Bacteria,2G6XK@200795|Chloroflexi	200795|Chloroflexi	P	Zinc-uptake complex component A periplasmic	-	-	-	ko:K09818	-	M00243	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ZnuA
k59_1088319_1	83406.HDN1F_02530	3.73e-90	273.0	COG4221@1|root,COG4221@2|Bacteria,1QTXD@1224|Proteobacteria,1T1MG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_420718_1	243231.GSU1459	2.94e-57	190.0	COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,42M3V@68525|delta/epsilon subdivisions,2WJJ4@28221|Deltaproteobacteria,43T8H@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
k59_1477587_1	1150469.RSPPHO_00672	8.46e-138	410.0	COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,2TRVS@28211|Alphaproteobacteria,2JQKB@204441|Rhodospirillales	204441|Rhodospirillales	G	Belongs to the glycosyl hydrolase 13 family	glgX	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
k59_1532272_2	1288963.ADIS_3236	4.98e-07	50.8	COG1764@1|root,COG1764@2|Bacteria,4NQKB@976|Bacteroidetes,47QN1@768503|Cytophagia	976|Bacteroidetes	O	redox protein regulator of disulfide bond formation	osmC	-	-	ko:K04063	-	-	-	-	ko00000	-	-	-	OsmC
k59_1421332_1	561175.KB894100_gene4848	2.68e-14	77.8	COG0491@1|root,COG0491@2|Bacteria,2HFVZ@201174|Actinobacteria,4EFG8@85012|Streptosporangiales	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	ko:K05555	ko01057,ko01130,map01057,map01130	M00778	R09305	-	ko00000,ko00001,ko00002,ko01000,ko01008	-	-	-	Lactamase_B
k59_1366247_1	498848.TaqDRAFT_3967	2.69e-15	69.7	2BMUI@1|root,32GE2@2|Bacteria,1WKN5@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Protein of unknown function (DUF2905)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2905
k59_1366247_2	314278.NB231_08685	4.28e-43	158.0	COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,1RNC8@1236|Gammaproteobacteria,1WXBI@135613|Chromatiales	135613|Chromatiales	S	oligopeptide transporter	-	-	-	-	-	-	-	-	-	-	-	-	OPT
k59_586917_1	1382305.AZUC01000046_gene338	0.000453	46.6	COG0251@1|root,COG0251@2|Bacteria,1V6HG@1239|Firmicutes,4HC05@91061|Bacilli	91061|Bacilli	J	Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
k59_478340_1	1463853.JOHW01000015_gene184	1.36e-36	139.0	COG0477@1|root,COG2814@2|Bacteria,2GIR8@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
k59_1144481_1	266940.Krad_3528	5.89e-34	135.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,BTAD,HTH_31,Trans_reg_C
k59_864227_1	861299.J421_4450	5.72e-98	313.0	COG0466@1|root,COG0466@2|Bacteria,1ZTCH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_1700653_1	1283300.ATXB01000001_gene1393	6.67e-22	91.7	COG0284@1|root,COG0284@2|Bacteria,1MW2C@1224|Proteobacteria,1RNJR@1236|Gammaproteobacteria,1XEBB@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)	pyrF	GO:0003674,GO:0003824,GO:0004590,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
k59_1700653_2	1121878.AUGL01000011_gene817	2.04e-19	87.4	COG1295@1|root,COG1295@2|Bacteria,1QICW@1224|Proteobacteria,1RMKI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	UPF0761 membrane protein	rbn	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
k59_478343_1	987059.RBXJA2T_11797	9.33e-32	126.0	COG2199@1|root,COG4191@1|root,COG3706@2|Bacteria,COG4191@2|Bacteria,1MX83@1224|Proteobacteria,2VJP2@28216|Betaproteobacteria,1KPKS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Cache domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,dCache_1
k59_1421363_1	189425.PGRAT_06125	2.54e-07	54.3	COG4430@1|root,COG4430@2|Bacteria,1V1KQ@1239|Firmicutes,4HGIT@91061|Bacilli,275QQ@186822|Paenibacillaceae	91061|Bacilli	S	Bacteriocin-protection, YdeI or OmpD-Associated	-	-	-	-	-	-	-	-	-	-	-	-	OmdA
k59_1421363_2	452637.Oter_4323	1.59e-13	70.1	COG3797@1|root,COG3797@2|Bacteria,46WV6@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Protein of unknown function (DUF1697)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1697
k59_1256507_1	1397278.AYMV01000011_gene1686	2.41e-16	83.6	COG2079@1|root,COG2079@2|Bacteria,2GKUR@201174|Actinobacteria,4FMAS@85023|Microbacteriaceae	201174|Actinobacteria	S	MmgE/PrpD family	prpD	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009268,GO:0009628,GO:0009987,GO:0010447,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017001,GO:0017144,GO:0019541,GO:0019543,GO:0019626,GO:0019629,GO:0019679,GO:0019752,GO:0030312,GO:0032787,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046459,GO:0047547,GO:0050896,GO:0071704,GO:0071944,GO:0072329,GO:1901575	4.2.1.79	ko:K01720	ko00640,map00640	-	R04424	RC01152	ko00000,ko00001,ko01000	-	-	-	MmgE_PrpD
k59_531924_1	285514.JNWO01000005_gene2099	3.44e-47	174.0	COG5276@1|root,COG5276@2|Bacteria,2I3D6@201174|Actinobacteria	201174|Actinobacteria	L	WD40 repeats	-	-	-	-	-	-	-	-	-	-	-	-	WD40
k59_754202_1	93220.LV28_04685	4.43e-29	112.0	COG3803@1|root,COG3803@2|Bacteria,1RHYI@1224|Proteobacteria,2VSHT@28216|Betaproteobacteria,1K3V0@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Bacterial protein of unknown function (DUF924)	-	-	-	-	-	-	-	-	-	-	-	-	DUF924
k59_197703_1	36874.HQ34_05165	8.06e-70	218.0	COG0302@1|root,COG0302@2|Bacteria,4NFC2@976|Bacteroidetes,2FMYB@200643|Bacteroidia,22WSJ@171551|Porphyromonadaceae	976|Bacteroidetes	F	GTP cyclohydrolase 1	folE	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
k59_87056_2	552811.Dehly_0235	1.8e-07	54.7	COG1307@1|root,COG1307@2|Bacteria,2G6P2@200795|Chloroflexi,34CU6@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Uncharacterised protein, DegV family COG1307	-	-	-	-	-	-	-	-	-	-	-	-	DegV
k59_197705_1	1082933.MEA186_09545	9.26e-79	246.0	COG2072@1|root,COG2072@2|Bacteria,1MWPJ@1224|Proteobacteria,2TSQA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Flavoprotein involved in K transport	-	-	-	ko:K07222	-	-	-	-	ko00000	-	-	-	Pyr_redox_3
k59_549717_1	1268239.PALB_9130	4.17e-20	96.3	COG2176@1|root,COG2176@2|Bacteria,1QUVW@1224|Proteobacteria,1T2N1@1236|Gammaproteobacteria,2Q1IT@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	L	VRR_NUC	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	GIY-YIG,RNase_T,VRR_NUC
k59_48904_1	1227739.Hsw_0789	8.56e-38	145.0	COG1629@1|root,COG4771@2|Bacteria,4NF66@976|Bacteroidetes,47JMC@768503|Cytophagia	976|Bacteroidetes	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
k59_160979_1	314278.NB231_15378	2.5e-65	207.0	COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,1RPCE@1236|Gammaproteobacteria,1WXFS@135613|Chromatiales	135613|Chromatiales	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_1107039_1	706587.Desti_1350	1.17e-60	210.0	COG3280@1|root,COG3280@2|Bacteria,1QTVK@1224|Proteobacteria,42MEW@68525|delta/epsilon subdivisions,2WJX1@28221|Deltaproteobacteria,2MQXA@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	PFAM alpha amylase, catalytic	treY	-	5.4.99.15	ko:K06044	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01824,R09995	-	ko00000,ko00001,ko00002,ko01000	-	GH13	-	Alpha-amylase
k59_48909_1	1499967.BAYZ01000043_gene2307	2.95e-16	84.0	COG3899@1|root,COG3899@2|Bacteria	2|Bacteria	T	PFAM Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	AAA_16,Trans_reg_C
k59_1718651_1	396588.Tgr7_2900	8.28e-19	91.3	COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1WWZQ@135613|Chromatiales	135613|Chromatiales	T	response regulator receiver	-	-	-	ko:K02487,ko:K06596	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg
k59_160994_1	1340493.JNIF01000004_gene369	1.6e-09	62.8	COG3832@1|root,COG3832@2|Bacteria	2|Bacteria	J	glyoxalase III activity	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1,Polyketide_cyc2
k59_1331562_1	944479.JQLX01000016_gene335	4.2e-58	199.0	COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,42NR7@68525|delta/epsilon subdivisions,2WK49@28221|Deltaproteobacteria,2M6D9@213113|Desulfurellales	28221|Deltaproteobacteria	C	Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
k59_160997_1	1382306.JNIM01000001_gene2083	7.08e-33	131.0	COG1529@1|root,COG1529@2|Bacteria,2G8AB@200795|Chloroflexi	200795|Chloroflexi	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_1164165_1	479434.Sthe_3419	2.57e-12	63.5	COG1669@1|root,COG1669@2|Bacteria,2G76P@200795|Chloroflexi	200795|Chloroflexi	L	PFAM DNA polymerase, beta domain protein region	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	NTP_transf_2
k59_438924_1	545264.KB898746_gene796	1.3e-24	101.0	COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,1RR6K@1236|Gammaproteobacteria,1X2HB@135613|Chromatiales	135613|Chromatiales	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	ko:K02849	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
k59_497773_1	443143.GM18_1260	1.95e-23	106.0	COG4251@1|root,COG4936@1|root,COG5000@1|root,COG4251@2|Bacteria,COG4936@2|Bacteria,COG5000@2|Bacteria,1NSQ1@1224|Proteobacteria,42QPS@68525|delta/epsilon subdivisions,2WMWT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,HATPase_c,HisKA,PAS_4,PAS_8,PAS_9,dCache_1
k59_1107081_1	391735.Veis_4509	7.56e-33	130.0	COG0028@1|root,COG0028@2|Bacteria	2|Bacteria	EH	Belongs to the TPP enzyme family	ilvB2	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_658997_1	1352941.M877_05320	9.59e-52	182.0	COG0444@1|root,COG1173@1|root,COG0444@2|Bacteria,COG1173@2|Bacteria,2GIXV@201174|Actinobacteria	201174|Actinobacteria	EP	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
k59_1276879_1	926569.ANT_25190	7.73e-106	323.0	COG0493@1|root,COG0493@2|Bacteria,2G6SR@200795|Chloroflexi	200795|Chloroflexi	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.18.1.2,1.19.1.1	ko:K00528	-	-	R10159	-	ko00000,ko01000	-	-	-	Pyr_redox_2
k59_105359_1	1540221.JQNI01000002_gene1404	1.29e-70	228.0	COG0183@1|root,COG0183@2|Bacteria,1WIPU@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	Belongs to the thiolase family	-	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_1660802_1	518766.Rmar_2129	2.67e-102	310.0	COG0334@1|root,COG0334@2|Bacteria,4NEBH@976|Bacteroidetes,1FIWI@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	C	Belongs to the Glu Leu Phe Val dehydrogenases family	gdhA	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
k59_213770_1	1122164.JHWF01000016_gene1563	1.96e-89	276.0	COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,1RMR2@1236|Gammaproteobacteria,1JCJV@118969|Legionellales	118969|Legionellales	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_330618_1	1408428.JNJP01000085_gene2434	5.59e-56	191.0	COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,42M7X@68525|delta/epsilon subdivisions,2WJCA@28221|Deltaproteobacteria,2M7ZB@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
k59_1660816_1	1038860.AXAP01000088_gene3681	9.65e-62	198.0	COG1028@1|root,COG1028@2|Bacteria,1MUFX@1224|Proteobacteria,2TRWN@28211|Alphaproteobacteria,3JUHZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	MA20_20960	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_1331641_1	1173024.KI912148_gene4715	7.1e-68	213.0	COG1940@1|root,COG1940@2|Bacteria,1G0YU@1117|Cyanobacteria,1JJZG@1189|Stigonemataceae	1117|Cyanobacteria	GK	ROK family	ppgK	-	2.7.1.63	ko:K00886	ko00010,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R02187,R02189	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
k59_942620_1	368407.Memar_2026	9.01e-25	101.0	COG1985@1|root,arCOG01484@2157|Archaea,2XU47@28890|Euryarchaeota,2N96I@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM bifunctional deaminase-reductase domain protein	-	-	1.1.1.302	ko:K14654	ko00740,ko01100,map00740,map01100	-	R09375,R09376	RC00933	ko00000,ko00001,ko01000	-	-	-	RibD_C
k59_497835_2	67257.JODR01000005_gene2284	5.44e-59	193.0	COG0006@1|root,COG0006@2|Bacteria,2GM7D@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the peptidase M24B family	pepE	-	3.4.13.9	ko:K01271,ko:K01274	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
k59_884711_1	1104324.P186_0659	3.47e-34	125.0	COG0846@1|root,arCOG04248@2157|Archaea,2XQBQ@28889|Crenarchaeota	28889|Crenarchaeota	K	form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription	cobB	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
k59_604070_1	861299.J421_6109	7.22e-58	190.0	COG3279@1|root,COG3279@2|Bacteria,1ZUZN@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	LytTr DNA-binding domain	-	-	-	ko:K02477	-	-	-	-	ko00000,ko02022	-	-	-	LytTR,Response_reg
k59_549801_1	1123037.AUDE01000043_gene826	2.78e-10	65.9	2E3AK@1|root,331MR@2|Bacteria,4NXD2@976|Bacteroidetes,1I65G@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_771463_1	420662.Mpe_A1227	4.72e-17	78.6	2AHZN@1|root,318CZ@2|Bacteria,1Q06K@1224|Proteobacteria,2W4WA@28216|Betaproteobacteria,1KNW5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_771463_2	1042377.AFPJ01000023_gene661	6.38e-11	62.4	COG0811@1|root,COG0811@2|Bacteria,1PKF8@1224|Proteobacteria,1RRWP@1236|Gammaproteobacteria,465RQ@72275|Alteromonadaceae	1236|Gammaproteobacteria	U	COG0811 Biopolymer transport proteins	-	-	-	-	-	-	-	-	-	-	-	-	MotA_ExbB
k59_828327_1	402777.KB235898_gene5311	4.78e-15	80.1	COG0642@1|root,COG0784@1|root,COG2199@1|root,COG2202@1|root,COG2203@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG3706@2|Bacteria,1G09B@1117|Cyanobacteria,1H7T9@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
k59_942650_1	357808.RoseRS_2270	3.55e-33	130.0	COG1132@1|root,COG1132@2|Bacteria,2G7QN@200795|Chloroflexi,374U2@32061|Chloroflexia	32061|Chloroflexia	V	PFAM ABC transporter transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	ABC_membrane,ABC_tran
k59_270147_1	136993.KB900626_gene2691	4.99e-19	93.2	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,2TRTY@28211|Alphaproteobacteria,36XSK@31993|Methylocystaceae	28211|Alphaproteobacteria	T	CHASE2	cyaD	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
k59_884737_2	637910.ROD_26381	5.58e-18	84.0	COG2801@1|root,COG2801@2|Bacteria,1PUMN@1224|Proteobacteria,1RYSS@1236|Gammaproteobacteria,3WZ2S@544|Citrobacter	1236|Gammaproteobacteria	L	DDE domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
k59_1107161_2	1463821.JOGR01000003_gene899	1.51e-52	182.0	COG2133@1|root,COG2730@1|root,COG2133@2|Bacteria,COG2730@2|Bacteria,2I9ZW@201174|Actinobacteria	201174|Actinobacteria	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	CBM_2,GSDH
k59_1440050_2	1304883.KI912532_gene2111	4.53e-22	91.7	COG2020@1|root,COG2020@2|Bacteria,1N3YJ@1224|Proteobacteria,2VT4V@28216|Betaproteobacteria,2KWM8@206389|Rhodocyclales	206389|Rhodocyclales	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
k59_105450_2	867845.KI911784_gene835	5.2e-21	92.4	COG2120@1|root,COG2120@2|Bacteria,2G6W3@200795|Chloroflexi,375I3@32061|Chloroflexia	32061|Chloroflexia	S	PFAM LmbE family protein	-	-	3.5.1.115	ko:K18455	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
k59_1772683_1	926569.ANT_16170	9.92e-80	249.0	COG0499@1|root,COG0499@2|Bacteria,2G5X8@200795|Chloroflexi	200795|Chloroflexi	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
k59_1718761_1	880073.Calab_0032	1.73e-28	123.0	COG3408@1|root,COG3408@2|Bacteria,2NPYR@2323|unclassified Bacteria	2|Bacteria	G	Amylo-alpha-1,6-glucosidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF608,GDE_C,GDE_N_bis
k59_1660893_1	234267.Acid_5749	6.12e-16	82.4	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
k59_1277039_1	717605.Theco_0240	3.88e-07	58.5	COG0412@1|root,COG0412@2|Bacteria,1UMV9@1239|Firmicutes	1239|Firmicutes	Q	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_7
k59_330778_1	1122621.ATZA01000021_gene1750	3.64e-17	85.9	COG0577@1|root,COG0577@2|Bacteria,4NDUK@976|Bacteroidetes,1IQ1E@117747|Sphingobacteriia	976|Bacteroidetes	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_49106_1	1089552.KI911559_gene3112	3.04e-25	110.0	COG2982@1|root,COG2982@2|Bacteria,1MUAN@1224|Proteobacteria,2U26R@28211|Alphaproteobacteria,2JPQ3@204441|Rhodospirillales	204441|Rhodospirillales	M	AsmA family	-	-	-	ko:K07289,ko:K07290	-	-	-	-	ko00000	9.B.121	-	-	AsmA,AsmA_2
k59_942755_1	631454.N177_2554	1.78e-45	161.0	COG4536@1|root,COG4536@2|Bacteria,1NZ99@1224|Proteobacteria,2TVZH@28211|Alphaproteobacteria,1JNCN@119043|Rhodobiaceae	28211|Alphaproteobacteria	P	Domain of unknown function DUF21	corB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
k59_1052679_1	1122603.ATVI01000008_gene2233	2.81e-23	100.0	COG0491@1|root,COG0491@2|Bacteria	2|Bacteria	GM	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	blaB3	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_1331801_1	765914.ThisiDRAFT_1295	1.04e-101	309.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,1WX5F@135613|Chromatiales	135613|Chromatiales	NU	PFAM Type II secretion system protein E	-	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
k59_1497710_1	1449350.OCH239_16540	2.97e-40	147.0	COG0564@1|root,COG0564@2|Bacteria,1MUBN@1224|Proteobacteria,2TSBK@28211|Alphaproteobacteria,4KME4@93682|Roseivivax	28211|Alphaproteobacteria	J	Pseudouridine synthase	rluD	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
k59_330811_2	530564.Psta_4193	1.48e-32	126.0	COG0433@1|root,COG0433@2|Bacteria,2IY71@203682|Planctomycetes	203682|Planctomycetes	L	AAA-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF853,DUF87,PDDEXK_1
k59_1607035_1	1191523.MROS_1186	1.55e-75	243.0	COG3005@1|root,COG3005@2|Bacteria	2|Bacteria	C	denitrification pathway	-	GO:0003674,GO:0003824,GO:0005575,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0031224,GO:0044237,GO:0044425,GO:0045333,GO:0055114	-	ko:K15876	ko00910,ko01120,map00910,map01120	M00530	R05712	RC00176	ko00000,ko00001,ko00002	-	-	-	Cytochrom_NNT,Cytochrom_c3_2
k59_1497731_1	1120971.AUCA01000019_gene1106	3.72e-21	90.9	COG1386@1|root,COG1386@2|Bacteria,1V6HI@1239|Firmicutes,4HIQ0@91061|Bacilli,278E1@186823|Alicyclobacillaceae	91061|Bacilli	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	scpB	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
k59_1386207_1	545264.KB898755_gene2797	2.65e-96	300.0	COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,1RMCI@1236|Gammaproteobacteria,1WXIB@135613|Chromatiales	135613|Chromatiales	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parE	-	-	ko:K02622	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_1388694_2	1515746.HR45_04855	6.17e-21	84.3	2E78M@1|root,331S8@2|Bacteria,1NAG9@1224|Proteobacteria,1SCP5@1236|Gammaproteobacteria,2QCSH@267890|Shewanellaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_272260_1	357808.RoseRS_3056	3.77e-100	301.0	COG1172@1|root,COG1172@2|Bacteria,2G8WV@200795|Chloroflexi,377N4@32061|Chloroflexia	32061|Chloroflexia	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057,ko:K10440	ko02010,map02010	M00212,M00221	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
k59_887637_1	1120999.JONM01000014_gene2826	5.19e-44	149.0	2C8XG@1|root,2Z7PK@2|Bacteria,1RA5I@1224|Proteobacteria,2VQGY@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF4197)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4197
k59_887637_2	391624.OIHEL45_16099	1.79e-16	78.6	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQNK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	COG1593 TRAP-type C4-dicarboxylate transport system, large permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_1720355_1	572478.Vdis_0348	1.65e-12	72.8	COG0303@1|root,COG1910@1|root,arCOG00217@2157|Archaea,arCOG00230@2157|Archaea,2XPP4@28889|Crenarchaeota	28889|Crenarchaeota	H	MoeA domain protein domain I and II	-	-	2.10.1.1	ko:K03750,ko:K07219	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N,PBP_like
k59_51347_1	1379270.AUXF01000006_gene30	3.04e-29	120.0	COG0760@1|root,COG0760@2|Bacteria,1ZTD1@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	SurA N-terminal domain	-	-	5.2.1.8	ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_2,SurA_N_2
k59_606027_1	1173020.Cha6605_1165	5.72e-09	53.9	COG3093@1|root,COG3093@2|Bacteria,1G82A@1117|Cyanobacteria	1117|Cyanobacteria	K	TIGRFAM addiction module antidote protein, HigA family	-	-	-	ko:K21498	-	-	-	-	ko00000,ko02048	-	-	-	HTH_3
k59_1285068_1	1033732.CAHI01000005_gene1924	3.71e-07	57.8	COG3119@1|root,COG3119@2|Bacteria,4NGX1@976|Bacteroidetes,2FMSX@200643|Bacteroidia,22UZG@171550|Rikenellaceae	976|Bacteroidetes	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
k59_1340683_1	926569.ANT_14860	1.37e-91	281.0	COG1167@1|root,COG1167@2|Bacteria,2G61E@200795|Chloroflexi	200795|Chloroflexi	EK	PFAM Aminotransferase class I and II	-	-	-	ko:K05825	ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210	-	R01939	RC00006	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2
k59_1173843_1	1336233.JAEH01000055_gene4125	1.43e-13	74.7	COG0491@1|root,COG0491@2|Bacteria,1PBSA@1224|Proteobacteria,1SWGM@1236|Gammaproteobacteria,2QE2R@267890|Shewanellaceae	1236|Gammaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_729404_2	1042375.AFPL01000046_gene1960	4.52e-22	98.2	COG2199@1|root,COG3706@2|Bacteria,1NECV@1224|Proteobacteria,1S1ZR@1236|Gammaproteobacteria,46766@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	COG2199 FOG GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,GAF_2,GGDEF
k59_617827_2	1238182.C882_1179	5.3e-06	47.0	COG5502@1|root,COG5502@2|Bacteria,1NB8V@1224|Proteobacteria,2U9GZ@28211|Alphaproteobacteria,2JUEH@204441|Rhodospirillales	204441|Rhodospirillales	S	Uncharacterized conserved protein (DUF2267)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2267
k59_617827_3	1144275.COCOR_07114	3.17e-09	57.8	COG0438@1|root,COG0438@2|Bacteria,1MYTB@1224|Proteobacteria,42MCA@68525|delta/epsilon subdivisions,2WJVX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM Glycosyl transferase, group 1	-	-	2.4.1.245	ko:K13057	ko00500,ko01100,map00500,map01100	-	R08946,R10525,R11306	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000	-	GT4	-	Glycos_transf_1
k59_1563040_1	1123023.JIAI01000002_gene5639	1.55e-35	139.0	COG1403@1|root,COG1403@2|Bacteria,2INVR@201174|Actinobacteria	201174|Actinobacteria	V	HNH nucleases	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
k59_1173860_1	1178482.BJB45_09245	1.9e-100	299.0	COG2057@1|root,COG2057@2|Bacteria,1MY3S@1224|Proteobacteria,1RP1U@1236|Gammaproteobacteria,1XMGE@135619|Oceanospirillales	135619|Oceanospirillales	I	transferase	-	-	2.8.3.12	ko:K01040	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
k59_1173860_2	1464048.JNZS01000007_gene4474	1.26e-19	86.7	COG1414@1|root,COG1414@2|Bacteria,2GNHA@201174|Actinobacteria,4D9QJ@85008|Micromonosporales	201174|Actinobacteria	K	Transcriptional regulator	pcaR	-	-	ko:K02624	-	-	-	-	ko00000,ko03000	-	-	-	HTH_IclR,IclR
k59_784708_1	1238182.C882_2235	5.58e-50	168.0	COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,2TR0T@28211|Alphaproteobacteria,2JPBV@204441|Rhodospirillales	204441|Rhodospirillales	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
k59_784708_2	1380394.JADL01000009_gene3288	1.04e-07	53.5	COG1721@1|root,COG1721@2|Bacteria,1MWPG@1224|Proteobacteria,2TTDX@28211|Alphaproteobacteria,2JPHZ@204441|Rhodospirillales	204441|Rhodospirillales	S	conserved protein (some members contain a von Willebrand factor type A (vWA) domain)	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
k59_1230213_1	1144275.COCOR_01938	3.04e-58	191.0	COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,42R1W@68525|delta/epsilon subdivisions,2WMQ4@28221|Deltaproteobacteria,2YVHS@29|Myxococcales	28221|Deltaproteobacteria	G	Inositol monophosphatase	suhB	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
k59_617850_1	330214.NIDE0892	4.08e-33	119.0	29E6W@1|root,3014W@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_617850_2	330214.NIDE0891	2.58e-46	157.0	COG0535@1|root,COG0535@2|Bacteria,3J0X6@40117|Nitrospirae	40117|Nitrospirae	S	Domain of unknown function (DUF3463)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3463,Radical_SAM
k59_228943_1	926562.Oweho_1395	6.12e-57	185.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
k59_1674280_1	1280676.AUJO01000030_gene1245	4.9e-40	148.0	COG1134@1|root,COG1134@2|Bacteria,1TQKK@1239|Firmicutes,24A5V@186801|Clostridia,4BXB9@830|Butyrivibrio	186801|Clostridia	GM	Wzt C-terminal domain	-	-	3.6.3.40	ko:K01990,ko:K09691,ko:K09693	ko02010,map02010	M00250,M00251,M00254	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.103,3.A.1.104	-	-	ABC_tran,Wzt_C
k59_1340737_1	246194.CHY_2563	2.83e-85	262.0	COG0216@1|root,COG0216@2|Bacteria,1TQ7V@1239|Firmicutes,248CN@186801|Clostridia,42FEW@68295|Thermoanaerobacterales	186801|Clostridia	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
k59_506887_1	1435356.Y013_24500	6.54e-18	87.4	COG0491@1|root,COG0491@2|Bacteria,2GMDD@201174|Actinobacteria,4FZD4@85025|Nocardiaceae	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_284548_2	234267.Acid_2723	1.75e-18	82.8	2DBN7@1|root,2ZA2Y@2|Bacteria,3Y6N3@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF4159)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4159
k59_562199_1	1121935.AQXX01000056_gene1488	1.03e-97	317.0	COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,1XH56@135619|Oceanospirillales	135619|Oceanospirillales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_896202_1	247490.KSU1_C1314	1.4e-71	235.0	COG0535@1|root,COG0535@2|Bacteria,2J2KS@203682|Planctomycetes	203682|Planctomycetes	S	Proto-chlorophyllide reductase 57 kD subunit	-	-	-	-	-	-	-	-	-	-	-	-	PCP_red,Radical_SAM,SPASM
k59_228978_1	1382359.JIAL01000001_gene2735	2.19e-14	78.6	COG0383@1|root,COG0383@2|Bacteria,3Y3ID@57723|Acidobacteria,2JINT@204432|Acidobacteriia	204432|Acidobacteriia	G	Glycosyl hydrolase 38 domain protein	-	-	3.2.1.24	ko:K01191	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04131	-	GH38	-	Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C
k59_339838_1	926569.ANT_14810	1.58e-76	254.0	COG1529@1|root,COG2080@1|root,COG1529@2|Bacteria,COG2080@2|Bacteria,2G65D@200795|Chloroflexi	200795|Chloroflexi	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2
k59_1729863_1	1380394.JADL01000020_gene1826	1.43e-54	183.0	COG0742@1|root,COG0742@2|Bacteria,1MW6A@1224|Proteobacteria,2TQNI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	ribosomal rna small subunit methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1007354_1	1499967.BAYZ01000091_gene3428	1.43e-10	67.0	COG2067@1|root,COG2067@2|Bacteria	2|Bacteria	I	long-chain fatty acid transporting porin activity	-	-	-	ko:K06076	-	-	-	-	ko00000,ko02000	1.B.9	-	-	OprB,PorP_SprF,SLH,Toluene_X
k59_1618522_1	926569.ANT_08710	1.94e-31	127.0	COG0358@1|root,COG0358@2|Bacteria,2G65X@200795|Chloroflexi	200795|Chloroflexi	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
k59_1396378_1	575540.Isop_2672	1.47e-15	75.5	COG0589@1|root,COG0589@2|Bacteria,2J0XB@203682|Planctomycetes	203682|Planctomycetes	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_840240_1	1401328.P856_105	2.22e-05	46.6	COG3551@1|root,COG3551@2|Bacteria,1RB2G@1224|Proteobacteria,2U7MV@28211|Alphaproteobacteria,2JT3X@204441|Rhodospirillales	204441|Rhodospirillales	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_617912_1	344747.PM8797T_06617	2.27e-76	238.0	COG0573@1|root,COG0573@2|Bacteria,2IZ0E@203682|Planctomycetes	203682|Planctomycetes	P	probably responsible for the translocation of the substrate across the membrane	-	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
k59_784790_1	765420.OSCT_1356	2.81e-35	134.0	COG2211@1|root,COG2211@2|Bacteria,2G6B9@200795|Chloroflexi,3767E@32061|Chloroflexia	32061|Chloroflexia	G	major facilitator superfamily MFS_1	-	-	-	ko:K08226	-	-	-	-	ko00000,ko02000	2.A.1.41	-	-	PUCC
k59_6721_1	232721.Ajs_0026	8.37e-50	176.0	COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,2VIGG@28216|Betaproteobacteria,4AAPK@80864|Comamonadaceae	28216|Betaproteobacteria	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	-	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
k59_1173956_1	1296415.JACC01000032_gene642	5.49e-29	121.0	COG1020@1|root,COG1020@2|Bacteria	2|Bacteria	Q	D-alanine [D-alanyl carrier protein] ligase activity	-	-	-	ko:K15654	ko01054,ko02024,map01054,map02024	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
k59_117525_1	1121015.N789_11145	1.1e-37	144.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,1RR36@1236|Gammaproteobacteria,1X4T9@135614|Xanthomonadales	135614|Xanthomonadales	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
k59_784820_1	639282.DEFDS_0202	3.3e-34	127.0	COG0739@1|root,COG0739@2|Bacteria,2GF3Z@200930|Deferribacteres	200930|Deferribacteres	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_896263_1	1304865.JAGF01000001_gene585	3.43e-26	109.0	COG2252@1|root,COG2252@2|Bacteria,2GKYD@201174|Actinobacteria,4F0DV@85016|Cellulomonadaceae	201174|Actinobacteria	S	Permease family	pbuG	-	-	ko:K06901	-	-	-	-	ko00000,ko02000	2.A.1.40	-	-	Xan_ur_permease
k59_284620_1	1123037.AUDE01000008_gene763	2.89e-105	326.0	COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,4NE4A@976|Bacteroidetes,1HYUM@117743|Flavobacteriia	976|Bacteroidetes	C	Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type	pdhB	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
k59_1396420_2	1254432.SCE1572_04480	1.32e-27	115.0	COG1716@1|root,COG2203@1|root,COG3829@1|root,COG1716@2|Bacteria,COG2203@2|Bacteria,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,43BKG@68525|delta/epsilon subdivisions,2X6YI@28221|Deltaproteobacteria,2YZGR@29|Myxococcales	28221|Deltaproteobacteria	KT	Sigma-54 interaction domain	-	-	-	ko:K02584	ko02020,map02020	-	-	-	ko00000,ko00001,ko03000	-	-	-	FHA,GAF,GAF_2,HTH_8,Sigma54_activat,Yop-YscD_cpl
k59_1007406_1	292415.Tbd_2634	7.64e-22	101.0	COG2199@1|root,COG2202@1|root,COG2202@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2WHF0@28216|Betaproteobacteria,1KTCS@119069|Hydrogenophilales	119069|Hydrogenophilales	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
k59_1563165_1	58123.JOFJ01000003_gene1998	1.18e-08	60.8	COG0596@1|root,COG0596@2|Bacteria,2I8EU@201174|Actinobacteria,4EQPH@85012|Streptosporangiales	201174|Actinobacteria	S	Serine aminopeptidase, S33	lipV	GO:0003674,GO:0003824,GO:0005488,GO:0005504,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008289,GO:0009056,GO:0009062,GO:0009268,GO:0009628,GO:0009987,GO:0010447,GO:0016042,GO:0016054,GO:0016298,GO:0016787,GO:0016788,GO:0019752,GO:0031406,GO:0032787,GO:0033293,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0050896,GO:0051716,GO:0071214,GO:0071467,GO:0071468,GO:0071704,GO:0072329,GO:0104004,GO:1901575	-	ko:K19311	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_6
k59_1452268_1	717785.HYPMC_1361	1.99e-62	204.0	COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,2TR87@28211|Alphaproteobacteria,3N633@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
k59_784837_1	1123355.JHYO01000011_gene1476	4.88e-20	92.0	COG0745@1|root,COG0745@2|Bacteria,1N5U3@1224|Proteobacteria,2UGU1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
k59_1396426_1	237609.PSAKL28_37000	1.13e-22	102.0	COG3182@1|root,COG3182@2|Bacteria,1MUX8@1224|Proteobacteria,1S33A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	PepSY-associated TM region	-	-	-	-	-	-	-	-	-	-	-	-	PepSY_TM
k59_62171_1	926556.Echvi_0516	4.53e-44	157.0	COG3534@1|root,COG3534@2|Bacteria,4NECK@976|Bacteroidetes,47JK0@768503|Cytophagia	976|Bacteroidetes	G	Alpha-L-arabinofuranosidase C-terminus	-	-	3.2.1.55	ko:K01209	ko00520,map00520	-	R01762	-	ko00000,ko00001,ko01000	-	GH51	-	Alpha-L-AF_C
k59_395705_1	861299.J421_4428	4.72e-94	286.0	COG0761@1|root,COG0761@2|Bacteria,1ZTGU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	LytB protein	-	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
k59_451520_1	1379270.AUXF01000002_gene1585	9.47e-88	283.0	COG0515@1|root,COG0515@2|Bacteria,1ZUMJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
k59_1062768_1	379066.GAU_1115	1.76e-58	186.0	COG2018@1|root,COG2018@2|Bacteria,1ZTK7@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Roadblock/LC7 domain	-	-	-	-	-	-	-	-	-	-	-	-	Robl_LC7
k59_1285245_1	357808.RoseRS_2905	0.000725	41.2	COG0236@1|root,COG0304@1|root,COG1028@1|root,COG3321@1|root,COG0236@2|Bacteria,COG0304@2|Bacteria,COG1028@2|Bacteria,COG3321@2|Bacteria,2G68I@200795|Chloroflexi,3765Y@32061|Chloroflexia	32061|Chloroflexia	IQ	PFAM short-chain dehydrogenase reductase SDR	-	-	-	ko:K15314	ko01059,ko01130,map01059,map01130	M00824,M00825	R11435	-	ko00000,ko00001,ko00002,ko01008	-	-	-	Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
k59_1285245_2	292.DM42_376	0.00018	50.4	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2VH3R@28216|Betaproteobacteria,1JZVT@119060|Burkholderiaceae	28216|Betaproteobacteria	C	acyl-CoA dehydrogenase	-	-	1.3.8.1	ko:K00248	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N
k59_173350_1	1120956.JHZK01000001_gene3457	4.68e-71	226.0	COG0604@1|root,COG0604@2|Bacteria,1MWBD@1224|Proteobacteria,2TS3Z@28211|Alphaproteobacteria,1JN6K@119043|Rhodobiaceae	1224|Proteobacteria	C	Zinc-binding dehydrogenase	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
k59_1674439_2	1114959.SZMC14600_12822	1.26e-24	96.7	COG4977@1|root,COG4977@2|Bacteria,2I3BT@201174|Actinobacteria,4E409@85010|Pseudonocardiales	201174|Actinobacteria	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
k59_1062801_1	379066.GAU_2419	3.2e-59	195.0	COG0859@1|root,COG0859@2|Bacteria,1ZT3G@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	ko:K12982	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
k59_339958_1	701176.VIBRN418_00666	0.000667	43.5	COG0076@1|root,COG0160@1|root,COG0076@2|Bacteria,COG0160@2|Bacteria,1MWUX@1224|Proteobacteria,1RQ8G@1236|Gammaproteobacteria,1XV42@135623|Vibrionales	135623|Vibrionales	E	COG0160 4-aminobutyrate aminotransferase and related aminotransferases	-	-	2.6.1.76,4.1.1.86	ko:K00836,ko:K13745	ko00260,ko01100,ko01120,ko01210,ko01230,map00260,map01100,map01120,map01210,map01230	M00033	R06977,R07650	RC00006,RC00062,RC00299	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3,Pyridoxal_deC
k59_339958_2	99598.Cal7507_5247	7.56e-51	169.0	COG1063@1|root,COG1063@2|Bacteria,1FZZE@1117|Cyanobacteria,1HJXK@1161|Nostocales	1117|Cyanobacteria	E	PFAM Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N,Shikimate_DH
k59_62216_1	485913.Krac_5027	2.12e-27	115.0	COG2909@1|root,COG3903@1|root,COG2909@2|Bacteria,COG3903@2|Bacteria,2G7SC@200795|Chloroflexi	200795|Chloroflexi	K	intracellular signal transduction	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,TPR_12
k59_1340881_1	1392490.JHZX01000001_gene764	1.28e-07	57.8	COG3533@1|root,COG3533@2|Bacteria,4NF8W@976|Bacteroidetes,1HYF5@117743|Flavobacteriia	976|Bacteroidetes	S	glycosyl hydrolase of	-	-	-	ko:K09955	-	-	-	-	ko00000	-	-	-	DUF4986,Glyco_hydro_127
k59_1340881_2	332101.JIBU02000005_gene275	3e-14	74.7	COG0682@1|root,COG0682@2|Bacteria,1TPAK@1239|Firmicutes,24BK7@186801|Clostridia,36EP7@31979|Clostridiaceae	186801|Clostridia	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
k59_229116_1	861299.J421_3566	1.16e-49	179.0	COG0653@1|root,COG0653@2|Bacteria,1ZSMK@142182|Gemmatimonadetes	142182|Gemmatimonadetes	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_284695_1	671143.DAMO_2142	3.16e-130	403.0	COG0458@1|root,COG0458@2|Bacteria,2NNPB@2323|unclassified Bacteria	2|Bacteria	EF	Carbamoyl-phosphate synthetase ammonia chain	carB	GO:0000050,GO:0000166,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016053,GO:0016597,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0071941,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b0033,iBWG_1329.BWG_0031,iECDH10B_1368.ECDH10B_0034,iECDH1ME8569_1439.ECDH1ME8569_0031,iECUMN_1333.ECUMN_0034,iEcDH1_1363.EcDH1_3566,iJN746.PP_4723,iJO1366.b0033,iJR904.b0033,iPC815.YPO0482,iY75_1357.Y75_RS00170,iYL1228.KPN_00041	CPSase_L_D2,CPSase_L_D3,MGS
k59_1563240_1	1121033.AUCF01000020_gene744	5.35e-105	317.0	COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,2TT03@28211|Alphaproteobacteria,2JPHV@204441|Rhodospirillales	204441|Rhodospirillales	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
k59_562352_1	443598.AUFA01000010_gene157	1.27e-90	302.0	COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,3JTQ7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DZR,Guanylate_cyc,SAM_1
k59_1118830_1	1379270.AUXF01000002_gene1164	3.28e-72	243.0	COG0249@1|root,COG0249@2|Bacteria,1ZST5@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
k59_117624_1	545695.TREAZ_1181	1.85e-10	61.6	COG1664@1|root,COG1664@2|Bacteria,2J861@203691|Spirochaetes	203691|Spirochaetes	M	Integral membrane protein CcmA involved in cell shape determination	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
k59_1619827_1	1485545.JQLW01000006_gene270	1.61e-25	108.0	COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria	1224|Proteobacteria	M	zinc metalloprotease	rseP	GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006355,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016021,GO:0016787,GO:0019219,GO:0019222,GO:0019538,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0043170,GO:0043856,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0045152,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:0140110,GO:1901564,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
k59_1397696_1	269796.Rru_A0279	3.06e-93	283.0	COG1600@1|root,COG1600@2|Bacteria,1MV1H@1224|Proteobacteria,2TR5E@28211|Alphaproteobacteria,2JPW4@204441|Rhodospirillales	204441|Rhodospirillales	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	queG	-	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Fer4_16,HEAT_2
k59_952831_1	404589.Anae109_2994	3.36e-60	206.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,42MXV@68525|delta/epsilon subdivisions,2WIIT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR,POR_N
k59_508196_1	1313172.YM304_12060	1.71e-49	167.0	COG2513@1|root,COG2513@2|Bacteria,2GMQ4@201174|Actinobacteria	201174|Actinobacteria	G	COG2513 PEP phosphonomutase and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	PEP_mutase
k59_563546_2	234267.Acid_4751	1.4e-05	50.1	COG0517@1|root,COG0517@2|Bacteria,3Y6WE@57723|Acidobacteria	57723|Acidobacteria	S	Putative transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
k59_8066_1	402881.Plav_2504	5.1e-34	127.0	COG2175@1|root,COG2175@2|Bacteria,1Q8GZ@1224|Proteobacteria,2VCP6@28211|Alphaproteobacteria,1JQ4Y@119043|Rhodobiaceae	28211|Alphaproteobacteria	Q	Taurine catabolism dioxygenase TauD, TfdA family	-	-	1.14.11.17	ko:K03119	ko00430,ko00920,map00430,map00920	-	R05320	RC01331	ko00000,ko00001,ko01000	-	-	-	TauD
k59_730865_2	1896.JOAU01000005_gene4968	2.11e-56	189.0	COG0436@1|root,COG0436@2|Bacteria,2GJ7R@201174|Actinobacteria	201174|Actinobacteria	E	Aminotransferase	aspC	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_952840_1	1382359.JIAL01000001_gene1135	4.94e-64	203.0	COG2227@1|root,COG2227@2|Bacteria,3Y9AQ@57723|Acidobacteria	57723|Acidobacteria	H	Thiopurine S-methyltransferase (TPMT)	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1175284_1	383372.Rcas_3033	1.2e-69	232.0	COG0471@1|root,COG3273@1|root,COG0471@2|Bacteria,COG3273@2|Bacteria,2G7T5@200795|Chloroflexi,376H4@32061|Chloroflexia	32061|Chloroflexia	P	TRAP C4-dicarboxylate transport system permease DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,TrkA_C
k59_1064064_1	556269.ACDQ01000002_gene1063	7.13e-22	94.7	COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,2VI9W@28216|Betaproteobacteria,473D3@75682|Oxalobacteraceae	28216|Betaproteobacteria	O	HflC and HflK could regulate a protease	hflC	-	-	ko:K04087	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
k59_1064064_2	1123504.JQKD01000031_gene4568	1e-11	60.8	COG3242@1|root,COG3242@2|Bacteria,1NG9Q@1224|Proteobacteria,2VXNJ@28216|Betaproteobacteria,4AFHA@80864|Comamonadaceae	28216|Betaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2065)	-	-	-	ko:K09937	-	-	-	-	ko00000	-	-	-	DUF2065
k59_1689992_1	264203.ZMO1668	2.35e-14	73.2	COG1495@1|root,COG1495@2|Bacteria,1N89I@1224|Proteobacteria,2UF49@28211|Alphaproteobacteria,2K59V@204457|Sphingomonadales	204457|Sphingomonadales	O	Disulfide bond formation protein	-	-	-	-	-	-	-	-	-	-	-	-	DsbB
k59_1689992_2	1380394.JADL01000003_gene5222	2.29e-51	168.0	COG2941@1|root,COG2941@2|Bacteria,1RAK4@1224|Proteobacteria,2U85I@28211|Alphaproteobacteria,2JSA9@204441|Rhodospirillales	204441|Rhodospirillales	H	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol	coq7	-	-	ko:K06134	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00128	R04984,R08775	RC01254	ko00000,ko00001,ko00002,ko01000	-	-	-	COQ7
k59_411342_1	379066.GAU_1168	6.64e-111	335.0	COG1012@1|root,COG1012@2|Bacteria,1ZST9@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Aldehyde dehydrogenase family	-	-	-	ko:K22187	ko00040,map00040	-	R11768	RC00080	ko00000,ko00001,ko01000	-	-	-	Aldedh
k59_300164_1	329726.AM1_6084	3.52e-20	83.2	2DNVA@1|root,32ZBE@2|Bacteria,1GFXX@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_300164_2	574375.BAGA_18610	9.57e-34	125.0	COG0604@1|root,COG0604@2|Bacteria,1TSWF@1239|Firmicutes,4HANV@91061|Bacilli,1ZPZP@1386|Bacillus	91061|Bacilli	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
k59_244405_1	379066.GAU_2419	1.63e-48	167.0	COG0859@1|root,COG0859@2|Bacteria,1ZT3G@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	ko:K12982	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
k59_967507_1	196162.Noca_0039	5.29e-10	61.2	COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria,4DPU8@85009|Propionibacteriales	201174|Actinobacteria	C	PFAM L-carnitine dehydratase bile acid-inducible protein F	-	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
k59_967507_2	1173024.KI912151_gene2025	1e-15	73.6	COG1764@1|root,COG1764@2|Bacteria,1G767@1117|Cyanobacteria	1117|Cyanobacteria	O	OsmC-like protein	-	-	-	ko:K04063	-	-	-	-	ko00000	-	-	-	OsmC
k59_800713_1	861299.J421_1935	2.37e-53	191.0	COG2091@1|root,COG2091@2|Bacteria,1ZU9H@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_188607_1	926569.ANT_29130	4.61e-47	160.0	COG0348@1|root,COG0348@2|Bacteria	2|Bacteria	C	4 iron, 4 sulfur cluster binding	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5
k59_188607_2	926569.ANT_29120	1.22e-46	158.0	COG0348@1|root,COG0348@2|Bacteria,2G8SY@200795|Chloroflexi	200795|Chloroflexi	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_5
k59_1412078_1	314264.ROS217_09045	8.64e-80	253.0	COG2211@1|root,COG2211@2|Bacteria,1MWSH@1224|Proteobacteria,2U0DN@28211|Alphaproteobacteria,46QAF@74030|Roseovarius	28211|Alphaproteobacteria	G	BT1 family	-	-	-	-	-	-	-	-	-	-	-	-	BT1
k59_1745114_1	575540.Isop_2672	5.28e-16	77.4	COG0589@1|root,COG0589@2|Bacteria,2J0XB@203682|Planctomycetes	203682|Planctomycetes	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_1134664_1	1120941.AUBL01000003_gene1831	1.28e-06	56.2	COG5002@1|root,COG5002@2|Bacteria,2GJ2D@201174|Actinobacteria,4D32P@85005|Actinomycetales	201174|Actinobacteria	T	ATPase histidine kinase DNA gyrase B HSP90 domain protein	mtrB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	2.7.13.3	ko:K07636,ko:K07654	ko02020,map02020	M00434,M00461	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
k59_800726_1	331113.SNE_A14250	3.01e-105	310.0	COG0447@1|root,COG0447@2|Bacteria,2JFGT@204428|Chlamydiae	204428|Chlamydiae	H	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)	menB	-	4.1.3.36	ko:K01661	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R07263	RC01923	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
k59_800726_2	888064.HMPREF9088_0654	5.44e-26	107.0	COG0596@1|root,COG0596@2|Bacteria,1TS4C@1239|Firmicutes,4HB6G@91061|Bacilli,4B5Z9@81852|Enterococcaceae	91061|Bacilli	S	Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC)	menH	GO:0003674,GO:0003824,GO:0016787	4.2.99.20	ko:K08680	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R08166	RC02148,RC02475	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_6
k59_1356693_1	391612.CY0110_28954	9.47e-08	57.8	COG2114@1|root,COG2203@1|root,COG2114@2|Bacteria,COG2203@2|Bacteria,1G0F6@1117|Cyanobacteria,3KH5G@43988|Cyanothece	1117|Cyanobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	cyaC	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	GAF,Guanylate_cyc,HATPase_c,HisKA,Response_reg
k59_188641_2	246197.MXAN_7220	1.87e-41	148.0	COG0006@1|root,COG0006@2|Bacteria,1MVHD@1224|Proteobacteria	1224|Proteobacteria	E	Xaa-Pro aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M24
k59_1189704_1	1187848.AJYQ01000036_gene2746	1.11e-79	256.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,1TFGC@1236|Gammaproteobacteria,1Y0A3@135623|Vibrionales	135623|Vibrionales	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_1633452_1	1183438.GKIL_2770	3.23e-45	167.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,1G1EB@1117|Cyanobacteria	1117|Cyanobacteria	KLT	serine threonine protein kinase	-	-	2.7.1.37,2.7.11.1	ko:K00870,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	FHA,Pkinase,TPR_11,TPR_16,TPR_8
k59_244452_1	298655.KI912266_gene1943	1.4e-90	286.0	COG1217@1|root,COG1217@2|Bacteria,2GJUJ@201174|Actinobacteria,4ES8A@85013|Frankiales	201174|Actinobacteria	T	GTP-binding protein TypA	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
k59_1633462_1	1380393.JHVP01000004_gene557	4.91e-33	122.0	COG2159@1|root,COG2159@2|Bacteria,2GMQY@201174|Actinobacteria,4EWAG@85013|Frankiales	201174|Actinobacteria	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
k59_132890_1	218140.BPSY_2094	5.65e-13	71.6	COG4221@1|root,COG4221@2|Bacteria,2GMGQ@201174|Actinobacteria,4CZA7@85004|Bifidobacteriales	201174|Actinobacteria	S	Enoyl-(Acyl carrier protein) reductase	sdh	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	adh_short
k59_300244_1	1121106.JQKB01000014_gene5710	3.38e-101	316.0	COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria,2JREA@204441|Rhodospirillales	28211|Alphaproteobacteria	EQ	Hydantoinase/oxoprolinase N-terminal region	-	-	3.5.2.14,3.5.2.9	ko:K01469,ko:K01473	ko00330,ko00480,ko01100,map00330,map00480,map01100	-	R00251,R03187	RC00553,RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A,Hydantoinase_B
k59_689913_1	1122135.KB893157_gene382	4.09e-79	259.0	COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,2TUKS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	KL	helicase	dinG	-	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Helicase_C_2
k59_855080_1	1380390.JIAT01000011_gene2343	4e-17	85.9	COG1524@1|root,COG1524@2|Bacteria,2HH0Q@201174|Actinobacteria,4CRNQ@84995|Rubrobacteria	84995|Rubrobacteria	S	Mycobacterial 4 TMS phage holin, superfamily IV	-	-	-	-	-	-	-	-	-	-	-	-	Phage_holin_4_2,Phosphodiest
k59_632837_1	926569.ANT_06840	2.56e-93	286.0	COG0305@1|root,COG0305@2|Bacteria,2G64D@200795|Chloroflexi	200795|Chloroflexi	L	Participates in initiation and elongation during chromosome replication	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
k59_300274_1	1235279.C772_01046	1.34e-18	90.5	COG0747@1|root,COG0747@2|Bacteria,1TQ0N@1239|Firmicutes,4HARF@91061|Bacilli,26H18@186818|Planococcaceae	91061|Bacilli	E	Bacterial extracellular solute-binding proteins, family 5 Middle	appA	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_522714_1	1238182.C882_4156	3.05e-37	138.0	COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,2TQXJ@28211|Alphaproteobacteria,2JPKM@204441|Rhodospirillales	204441|Rhodospirillales	M	zinc metalloprotease	rseP	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
k59_522718_1	85643.Tmz1t_1855	1.68e-69	225.0	COG0701@1|root,COG0701@2|Bacteria,1MUN8@1224|Proteobacteria,2VNTF@28216|Betaproteobacteria,2KVB8@206389|Rhodocyclales	206389|Rhodocyclales	S	Predicted permease	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1
k59_467851_1	671143.DAMO_2491	3.21e-60	196.0	COG1028@1|root,COG1028@2|Bacteria,2NQBD@2323|unclassified Bacteria	2|Bacteria	IQ	NAD(P)H binding domain of trans-2-enoyl-CoA reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_411476_1	1095769.CAHF01000005_gene1480	3.45e-63	208.0	COG2982@1|root,COG2982@2|Bacteria,1NBZ0@1224|Proteobacteria,2VPGQ@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Domain of Unknown Function (DUF748)	-	-	-	-	-	-	-	-	-	-	-	-	DUF748
k59_188748_1	326427.Cagg_2762	1.6e-66	212.0	COG0451@1|root,COG0451@2|Bacteria,2G6ET@200795|Chloroflexi,375HU@32061|Chloroflexia	32061|Chloroflexia	M	short-chain dehydrogenase reductase SDR	-	-	5.1.3.10	ko:K12454	ko00520,map00520	-	R04266	RC00528	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
k59_1578911_1	1121033.AUCF01000029_gene326	3.21e-75	228.0	COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,2U5BM@28211|Alphaproteobacteria,2JS2Q@204441|Rhodospirillales	204441|Rhodospirillales	C	[2Fe-2S] binding domain	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
k59_1578911_2	1279038.KB907350_gene2867	1.84e-18	84.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria,2JQ9H@204441|Rhodospirillales	204441|Rhodospirillales	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_22470_1	1089552.KI911559_gene2555	3.23e-88	275.0	COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,2TQYG@28211|Alphaproteobacteria,2JPTK@204441|Rhodospirillales	204441|Rhodospirillales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
k59_522754_1	679200.HMPREF9333_02030	1.54e-54	192.0	COG0188@1|root,COG0188@2|Bacteria,1TP2Z@1239|Firmicutes,2482G@186801|Clostridia	186801|Clostridia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_132980_2	596151.DesfrDRAFT_2307	1.14e-41	151.0	COG0702@1|root,COG0702@2|Bacteria,1PDTN@1224|Proteobacteria,42M8X@68525|delta/epsilon subdivisions,2WJ5J@28221|Deltaproteobacteria,2M7RB@213115|Desulfovibrionales	28221|Deltaproteobacteria	GM	NAD-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2867,NAD_binding_10
k59_355266_1	1380346.JNIH01000022_gene3956	7.62e-40	148.0	COG0277@1|root,COG0277@2|Bacteria,2GK5U@201174|Actinobacteria	201174|Actinobacteria	C	PFAM FAD linked oxidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
k59_1301029_1	1500304.JQKY01000018_gene781	1.42e-46	165.0	COG0520@1|root,COG0520@2|Bacteria,1MX5B@1224|Proteobacteria,2TVGK@28211|Alphaproteobacteria,4BCKU@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
k59_1356833_1	1121127.JAFA01000010_gene3936	6.24e-09	58.5	COG2706@1|root,COG2706@2|Bacteria,1NG69@1224|Proteobacteria	1224|Proteobacteria	G	Lactonase, 7-bladed beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
k59_1189863_1	1121456.ATVA01000015_gene2498	1.94e-102	309.0	COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,42M5M@68525|delta/epsilon subdivisions,2WM27@28221|Deltaproteobacteria,2MEJA@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	Cytochrome C and Quinol oxidase polypeptide I	ccoN	-	1.9.3.1	ko:K00404	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	COX1
k59_1134831_1	926560.KE387023_gene3263	7.19e-38	145.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,1WM5I@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,TPR_12
k59_800897_1	1286093.C266_06394	1.18e-75	239.0	COG0624@1|root,COG0624@2|Bacteria,1MVUX@1224|Proteobacteria,2VHQ8@28216|Betaproteobacteria,1K4DN@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Peptidase family M28	-	-	3.5.1.6,3.5.1.87	ko:K06016	ko00240,ko01100,map00240,map01100	M00046	R00905,R04666	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
k59_577797_1	1229205.BUPH_02101	3.62e-16	80.9	COG0457@1|root,COG3710@1|root,COG3903@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG3903@2|Bacteria,1PYUK@1224|Proteobacteria,2WETX@28216|Betaproteobacteria,1KHVS@119060|Burkholderiaceae	28216|Betaproteobacteria	K	transcriptional regulator, winged helix family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,NB-ARC,Trans_reg_C
k59_745257_1	930169.B5T_01767	1.84e-75	241.0	COG3385@1|root,COG3385@2|Bacteria,1MVRM@1224|Proteobacteria,1RTDH@1236|Gammaproteobacteria,1XQQP@135619|Oceanospirillales	135619|Oceanospirillales	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_300377_1	694431.DESACE_04815	9.09e-36	132.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,42NMG@68525|delta/epsilon subdivisions,2WJIS@28221|Deltaproteobacteria,2M6K9@213113|Desulfurellales	28221|Deltaproteobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	livG	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
k59_800908_1	1121430.JMLG01000002_gene1075	3.47e-09	61.6	COG2267@1|root,COG2267@2|Bacteria,1V4GY@1239|Firmicutes,25EJZ@186801|Clostridia,261ST@186807|Peptococcaceae	186801|Clostridia	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
k59_967707_1	926556.Echvi_1451	1.26e-07	54.7	COG2259@1|root,COG2259@2|Bacteria,4NSBJ@976|Bacteroidetes,47SCA@768503|Cytophagia	976|Bacteroidetes	S	DoxX	-	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
k59_188818_1	298655.KI912266_gene5298	1.57e-10	68.6	COG0358@1|root,COG0358@2|Bacteria,2GJFX@201174|Actinobacteria,4ERCW@85013|Frankiales	201174|Actinobacteria	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,DnaG_DnaB_bind,Toprim_4,Toprim_N,zf-CHC2
k59_802699_1	1123355.JHYO01000012_gene667	2.37e-40	152.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,36Z4F@31993|Methylocystaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	-	-	-	-	-	-	-	-	-	TctA
k59_969922_1	926569.ANT_21030	4.27e-81	255.0	COG1640@1|root,COG1640@2|Bacteria,2G668@200795|Chloroflexi	200795|Chloroflexi	G	PFAM glycoside hydrolase, family 77	malQ	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
k59_302359_1	1121877.JQKF01000011_gene424	8.34e-25	105.0	COG2755@1|root,COG2755@2|Bacteria,2GYQF@201174|Actinobacteria	201174|Actinobacteria	E	GDSL-like Lipase/Acylhydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
k59_190663_1	1121939.L861_01755	4.87e-46	168.0	COG3629@1|root,COG3629@2|Bacteria,1QU9N@1224|Proteobacteria	1224|Proteobacteria	K	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Abhydrolase_1,BTAD
k59_302363_1	1100720.ALKN01000033_gene808	4.72e-31	124.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VHFW@28216|Betaproteobacteria,4AAG0@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM L-carnitine dehydratase bile acid-inducible protein F	-	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
k59_1414067_1	861299.J421_0668	3.41e-81	258.0	COG5276@1|root,COG5276@2|Bacteria,1ZUNW@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_302372_1	652103.Rpdx1_3041	2.68e-32	132.0	28IH4@1|root,2Z8IE@2|Bacteria,1N4IS@1224|Proteobacteria,2U2RF@28211|Alphaproteobacteria,3JX5S@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_24419_1	1379270.AUXF01000006_gene206	1.41e-48	170.0	COG1066@1|root,COG1066@2|Bacteria,1ZSYF@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	ATPase
k59_1580970_1	1205680.CAKO01000038_gene1647	2.52e-76	239.0	COG1893@1|root,COG1893@2|Bacteria,1MVZ1@1224|Proteobacteria,2TRJN@28211|Alphaproteobacteria,2JV65@204441|Rhodospirillales	204441|Rhodospirillales	H	Ketopantoate reductase PanE/ApbA C terminal	-	-	-	-	-	-	-	-	-	-	-	-	ApbA,ApbA_C
k59_134885_1	1211813.CAPH01000006_gene1606	0.00052	47.8	COG0666@1|root,COG0666@2|Bacteria,4NEYY@976|Bacteroidetes,2FVRK@200643|Bacteroidia	976|Bacteroidetes	S	Ankyrin repeats (many copies)	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2,Ank_3,Ank_4,Ank_5,SHOCT,SecA_DEAD
k59_1303170_1	671143.DAMO_1590	1.8e-85	258.0	COG0755@1|root,COG0755@2|Bacteria,2NPG8@2323|unclassified Bacteria	2|Bacteria	O	Cytochrome C assembly protein	ccmC	GO:0001539,GO:0002048,GO:0002049,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006518,GO:0006629,GO:0006643,GO:0006664,GO:0006807,GO:0006810,GO:0006928,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009237,GO:0009247,GO:0009636,GO:0009987,GO:0015886,GO:0016020,GO:0016021,GO:0016209,GO:0016491,GO:0016684,GO:0019184,GO:0019290,GO:0019748,GO:0031224,GO:0031226,GO:0034641,GO:0040011,GO:0042221,GO:0043043,GO:0043107,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044425,GO:0044459,GO:0044464,GO:0044550,GO:0046467,GO:0048870,GO:0050896,GO:0051179,GO:0051181,GO:0051186,GO:0051188,GO:0051234,GO:0051674,GO:0051716,GO:0055114,GO:0070887,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0071973,GO:0071975,GO:0071977,GO:0071978,GO:0097237,GO:0097588,GO:0098754,GO:0098869,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1901678,GO:1903509,GO:1990748	-	ko:K02195	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	iECDH1ME8569_1439.ECDH1ME8569_2134,iSFV_1184.SFV_2275,iSFxv_1172.SFxv_2517,iUTI89_1310.UTI89_C2477,ic_1306.c2736	Cytochrom_C_asm
k59_1358733_1	1469245.JFBG01000009_gene574	8.04e-109	330.0	COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,1RP1F@1236|Gammaproteobacteria,1WX77@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	-	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC-associated,ThiC_Rad_SAM
k59_357381_1	446469.Sked_18480	2.13e-12	72.0	COG0815@1|root,COG0815@2|Bacteria,2GJ9F@201174|Actinobacteria	201174|Actinobacteria	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
k59_1249144_1	1379270.AUXF01000003_gene3453	5.67e-69	220.0	COG1960@1|root,COG1960@2|Bacteria,1ZSVE@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.6	ko:K00252	ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130	M00032	R02487,R02488,R10074	RC00052,RC00156	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_246336_1	385682.AFSL01000008_gene2632	6.75e-60	207.0	COG0726@1|root,COG0726@2|Bacteria,4NFJP@976|Bacteroidetes,2FNX2@200643|Bacteroidia,3XKJ3@558415|Marinilabiliaceae	976|Bacteroidetes	G	Glycosyl hydrolase family 9	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	CelD_N,Glyco_hydro_9,Polysacc_deac_1
k59_1635336_1	595460.RRSWK_02092	3.99e-89	279.0	COG1069@1|root,COG1069@2|Bacteria,2IY2X@203682|Planctomycetes	203682|Planctomycetes	G	FGGY family of carbohydrate kinases, N-terminal domain	araB	-	2.7.1.16	ko:K00853	ko00040,ko01100,map00040,map01100	-	R01526,R02439	RC00002,RC00538	ko00000,ko00001,ko01000	-	-	-	FGGY_C,FGGY_N
k59_1635340_1	1341679.P253_01015	5.04e-23	104.0	COG4372@1|root,COG4372@2|Bacteria,1MUCX@1224|Proteobacteria,1SU06@1236|Gammaproteobacteria,3NKH9@468|Moraxellaceae	1236|Gammaproteobacteria	S	IS66 C-terminal element	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
k59_1317594_1	1461577.CCMH01000005_gene1855	1.48e-18	90.9	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,4NE2Y@976|Bacteroidetes,1HZX5@117743|Flavobacteriia	976|Bacteroidetes	P	COGs COG0491 Zn-dependent hydrolase including glyoxylase	-	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B,Rhodanese
k59_870505_1	1390370.O203_02000	2.95e-05	47.0	COG0625@1|root,COG0625@2|Bacteria,1RHSK@1224|Proteobacteria,1RR26@1236|Gammaproteobacteria,1YKHV@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	O	Glutathione S-transferase, N-terminal domain	Z012_07295	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_N_3
k59_870505_2	189753.AXAS01000058_gene146	1.06e-50	163.0	COG0662@1|root,COG0662@2|Bacteria,1N1XN@1224|Proteobacteria,2U6GE@28211|Alphaproteobacteria,3JY7Y@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_316484_1	426114.THI_1678	2.48e-116	338.0	COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,2VHXJ@28216|Betaproteobacteria,1KJ75@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	PFAM Electron transfer flavoprotein alpha beta-subunit	etfB	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
k59_316484_2	391038.Bphy_4828	5.09e-16	76.6	COG2025@1|root,COG2025@2|Bacteria,1MUFI@1224|Proteobacteria,2VI6W@28216|Betaproteobacteria,1K1EZ@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Electron transfer flavoprotein	etfA	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
k59_1537670_1	574375.BAGA_29205	1.23e-07	58.9	COG0463@1|root,COG0500@1|root,COG1215@1|root,COG0463@2|Bacteria,COG1215@2|Bacteria,COG2226@2|Bacteria,1V659@1239|Firmicutes,4IS7V@91061|Bacilli,1ZI9W@1386|Bacillus	91061|Bacilli	MQ	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,Methyltransf_11
k59_1427058_1	1380350.JIAP01000004_gene5263	3.8e-14	76.6	COG1028@1|root,COG1028@2|Bacteria,1MUWP@1224|Proteobacteria,2TUTV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_592600_2	717773.Thicy_0281	6.42e-32	122.0	COG0628@1|root,COG0628@2|Bacteria,1MXXU@1224|Proteobacteria,1RQCM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	permease	tqsA	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0009372,GO:0009987,GO:0015562,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0044764,GO:0051179,GO:0051234,GO:0051704,GO:0055085,GO:0071944	-	ko:K11744	-	-	-	-	ko00000	-	-	-	AI-2E_transport
k59_1094084_1	760192.Halhy_6351	2.87e-06	51.2	COG2366@1|root,COG2366@2|Bacteria,4NEIX@976|Bacteroidetes,1IPU7@117747|Sphingobacteriia	976|Bacteroidetes	S	COG2366 Protein related to penicillin acylase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
k59_537617_1	1151122.AQYD01000004_gene2860	1.7e-76	246.0	COG1472@1|root,COG1472@2|Bacteria,2GJ5H@201174|Actinobacteria,4FMCS@85023|Microbacteriaceae	201174|Actinobacteria	G	Glycosyl hydrolase family 3 N terminal domain	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	F5_F8_type_C,Glyco_hydro_3,Glyco_hydro_3_C
k59_537619_1	1121920.AUAU01000021_gene2510	3.94e-83	261.0	COG1013@1|root,COG1014@1|root,COG1013@2|Bacteria,COG1014@2|Bacteria,3Y3G3@57723|Acidobacteria	57723|Acidobacteria	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	-	-	1.2.7.7	ko:K00187	ko00280,ko01100,map00280,map01100	-	R07160,R08566,R08567	RC00004,RC02833,RC02856	br01601,ko00000,ko00001,ko01000	-	-	-	POR,TPP_enzyme_C
k59_1094098_1	1197906.CAJQ02000003_gene3148	2.68e-12	67.4	COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,2TR7V@28211|Alphaproteobacteria,3JRG1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	DEAD/H associated	lhr	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
k59_1094098_2	570967.JMLV01000010_gene1237	2.69e-34	125.0	COG1407@1|root,COG1407@2|Bacteria,1RC5G@1224|Proteobacteria,2TU2T@28211|Alphaproteobacteria,2JS1N@204441|Rhodospirillales	204441|Rhodospirillales	S	Calcineurin-like phosphoesterase	-	-	-	ko:K06953	-	-	-	-	ko00000	-	-	-	Metallophos
k59_1537707_1	1157637.KB892113_gene4862	9.39e-104	311.0	COG1816@1|root,COG1816@2|Bacteria,2GJ6I@201174|Actinobacteria	201174|Actinobacteria	F	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism	add	GO:0003674,GO:0003824,GO:0004000,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006144,GO:0006152,GO:0006154,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009116,GO:0009119,GO:0009163,GO:0009164,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0042440,GO:0042451,GO:0042454,GO:0042455,GO:0042737,GO:0043094,GO:0043096,GO:0043101,GO:0043103,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046085,GO:0046100,GO:0046101,GO:0046102,GO:0046103,GO:0046112,GO:0046128,GO:0046129,GO:0046130,GO:0046148,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:1901135,GO:1901136,GO:1901137,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658,GO:1901659	3.5.4.4	ko:K01488	ko00230,ko01100,ko05340,map00230,map01100,map05340	-	R01560,R02556	RC00477	ko00000,ko00001,ko01000	-	-	iNJ661.Rv3313c	A_deaminase
k59_1427093_1	1123288.SOV_1c02950	1.02e-38	145.0	COG0243@1|root,COG0243@2|Bacteria,1TPZG@1239|Firmicutes,4H4MY@909932|Negativicutes	909932|Negativicutes	C	Anaerobic dimethyl sulfoxide reductase, A subunit, DmsA YnfE	-	-	1.8.5.3	ko:K07306	ko00920,map00920	-	R09501	RC02555	ko00000,ko00001,ko01000,ko02000	5.A.3.3	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_1262590_1	1416760.AYMS01000046_gene2688	2.39e-32	126.0	COG0079@1|root,COG0079@2|Bacteria,4NEW8@976|Bacteroidetes,1HXQE@117743|Flavobacteriia,47IN3@76831|Myroides	976|Bacteroidetes	E	Aminotransferase class I and II	-	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_316543_1	926569.ANT_31520	9.91e-85	260.0	COG3464@1|root,COG3464@2|Bacteria,2G9B1@200795|Chloroflexi	200795|Chloroflexi	L	Transposase IS66 family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66
k59_537645_1	1198232.CYCME_2404	7.35e-47	160.0	COG2513@1|root,COG2513@2|Bacteria,1N4VT@1224|Proteobacteria,1RMR5@1236|Gammaproteobacteria,46076@72273|Thiotrichales	72273|Thiotrichales	G	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate	prpB	-	4.1.3.30	ko:K03417	ko00640,map00640	-	R00409	RC00286,RC00287	ko00000,ko00001,ko01000	-	-	-	PEP_mutase
k59_537645_2	1380387.JADM01000009_gene3242	4.53e-09	57.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNT1@1236|Gammaproteobacteria,1XI36@135619|Oceanospirillales	135619|Oceanospirillales	C	Belongs to the citrate synthase family	prpC	-	2.3.3.5	ko:K01659	ko00640,map00640	-	R00931	RC00004,RC00406,RC02827	ko00000,ko00001,ko01000	-	-	-	Citrate_synt
k59_36663_1	861299.J421_3571	9.55e-106	334.0	COG0458@1|root,COG0458@2|Bacteria,1ZSPK@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Carbamoyl-phosphate synthetase large chain, oligomerisation domain	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_929656_1	1056820.KB900633_gene2079	4.02e-05	45.4	COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,1RMUG@1236|Gammaproteobacteria,2PMJD@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	O	Bacterial membrane protein N terminal	hflK	-	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7,HflK_N
k59_929656_2	1168065.DOK_18490	1.97e-74	231.0	COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,1RMF2@1236|Gammaproteobacteria,1J92E@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	HflC and HflK could regulate a protease	-	-	-	ko:K04087	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
k59_147571_1	997346.HMPREF9374_0632	1.52e-74	238.0	COG2262@1|root,COG2262@2|Bacteria,1TNZB@1239|Firmicutes,4HACA@91061|Bacilli,27BNI@186824|Thermoactinomycetaceae	91061|Bacilli	S	GTP-binding GTPase Middle Region	hflX	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0043021,GO:0043022,GO:0044424,GO:0044464,GO:0044877	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
k59_1594639_2	1316936.K678_15911	3.58e-14	73.2	COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,2TUHH@28211|Alphaproteobacteria,2JPDC@204441|Rhodospirillales	204441|Rhodospirillales	M	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis	lpxC	-	3.5.1.108	ko:K02535	ko00540,ko01100,map00540,map01100	M00060	R04587	RC00166,RC00300	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxC
k59_1594646_1	1122197.ATWI01000014_gene82	2.58e-54	172.0	COG3308@1|root,COG3308@2|Bacteria,1N5UB@1224|Proteobacteria,1SAAJ@1236|Gammaproteobacteria,4693B@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Predicted membrane protein (DUF2069)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2069
k59_1594646_2	1479237.JMLY01000001_gene1951	3.33e-19	87.4	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,4662Z@72275|Alteromonadaceae	1236|Gammaproteobacteria	NU	COG2804 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB	gspE	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
k59_1040512_1	1411123.JQNH01000001_gene1199	2.4e-98	293.0	COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,2TR9N@28211|Alphaproteobacteria	28211|Alphaproteobacteria	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
k59_1427146_1	1054213.HMPREF9946_04807	7.84e-07	56.2	COG0438@1|root,COG0438@2|Bacteria,1PDR7@1224|Proteobacteria,2U1R4@28211|Alphaproteobacteria,2JZEY@204441|Rhodospirillales	204441|Rhodospirillales	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4
k59_815612_1	1209989.TepiRe1_1402	1.65e-27	109.0	COG1514@1|root,COG1514@2|Bacteria,1VEU2@1239|Firmicutes,24MTR@186801|Clostridia,42H6P@68295|Thermoanaerobacterales	186801|Clostridia	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	ligT	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
k59_1537770_1	861299.J421_2886	5.28e-90	269.0	COG1100@1|root,COG1100@2|Bacteria,1ZSQI@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	ADP-ribosylation factor family	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	Arf
k59_592703_1	1121405.dsmv_1953	1.01e-51	177.0	COG0674@1|root,COG0674@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2WJG3@28221|Deltaproteobacteria,2MJ3H@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Pyruvate:ferredoxin oxidoreductase core domain II	-	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
k59_984264_1	63737.Npun_R3027	6.36e-55	194.0	COG0001@1|root,COG0318@1|root,COG1020@1|root,COG3321@1|root,COG0001@2|Bacteria,COG0318@2|Bacteria,COG1020@2|Bacteria,COG3321@2|Bacteria,1FZXE@1117|Cyanobacteria,1HIST@1161|Nostocales	1117|Cyanobacteria	Q	acyl transferase domain	-	-	-	ko:K16129	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Aminotran_3,Bac_luciferase,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,ketoacyl-synt
k59_870628_1	1236976.JCM16418_1563	3.17e-31	119.0	COG0647@1|root,COG0647@2|Bacteria,1TQGM@1239|Firmicutes,4HA3R@91061|Bacilli,26TV6@186822|Paenibacillaceae	91061|Bacilli	G	Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro	nagD	-	3.1.3.41	ko:K01101	ko00627,ko01120,map00627,map01120	-	R03024	RC00151	ko00000,ko00001,ko01000	-	-	-	Hydrolase_6,Hydrolase_like
k59_870628_2	265729.GS18_0217945	0.000217	44.3	COG0647@1|root,COG0647@2|Bacteria,1TQGM@1239|Firmicutes,4HA3R@91061|Bacilli,1ZB73@1386|Bacillus	91061|Bacilli	G	Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro	nagD	-	3.1.3.41	ko:K01101	ko00627,ko01120,map00627,map01120	-	R03024	RC00151	ko00000,ko00001,ko01000	-	-	-	Hydrolase_6,Hydrolase_like
k59_1150224_2	690850.Desaf_1703	2.68e-17	81.3	COG1148@1|root,COG1148@2|Bacteria,1R0SK@1224|Proteobacteria,43EFN@68525|delta/epsilon subdivisions,2X89E@28221|Deltaproteobacteria,2MHDW@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
k59_1594676_1	1123392.AQWL01000002_gene2096	0.000562	43.9	COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,2VHZU@28216|Betaproteobacteria,1KSME@119069|Hydrogenophilales	119069|Hydrogenophilales	O	UbiA prenyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	UbiA
k59_36709_1	1089547.KB913013_gene1003	4.55e-54	196.0	COG4206@1|root,COG4206@2|Bacteria,4P258@976|Bacteroidetes,47Y6D@768503|Cytophagia	976|Bacteroidetes	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Plug,STN,TonB_dep_Rec
k59_592714_1	1282361.ABAC402_01220	3.04e-76	246.0	COG3867@1|root,COG3867@2|Bacteria,1R33X@1224|Proteobacteria,2U17E@28211|Alphaproteobacteria,2KHND@204458|Caulobacterales	204458|Caulobacterales	G	PFAM glycosyl hydrolase 53 domain protein	-	-	3.2.1.89	ko:K01224	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_hydro_53
k59_1204776_2	984262.SGRA_3084	3.48e-22	94.0	COG0448@1|root,COG1209@1|root,COG0448@2|Bacteria,COG1209@2|Bacteria,4PMCK@976|Bacteroidetes,1J0PR@117747|Sphingobacteriia	976|Bacteroidetes	M	Nucleotidyl transferase	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
k59_1483666_1	1250006.JHZZ01000001_gene319	3.77e-19	90.1	COG4850@1|root,COG4850@2|Bacteria,4NFZ6@976|Bacteroidetes,1HX0X@117743|Flavobacteriia,3VX4V@52959|Polaribacter	976|Bacteroidetes	S	Uncharacterized conserved protein (DUF2183)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2183
k59_1150231_1	555778.Hneap_2051	3.28e-15	80.5	COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,1RNR3@1236|Gammaproteobacteria,1WWSJ@135613|Chromatiales	135613|Chromatiales	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
k59_592726_1	1282876.BAOK01000002_gene185	4.09e-50	178.0	COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,2TV0X@28211|Alphaproteobacteria,4BP5D@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Glyco_hydro_76,Thioredox_DsbH
k59_1707170_1	196162.Noca_1631	1.99e-73	230.0	COG0540@1|root,COG0540@2|Bacteria,2GKNA@201174|Actinobacteria,4DV65@85009|Propionibacteriales	201174|Actinobacteria	F	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_36724_2	883158.HMPREF9140_01126	8.53e-25	103.0	COG0500@1|root,COG2226@2|Bacteria,4NEDR@976|Bacteroidetes,2FMI3@200643|Bacteroidia	976|Bacteroidetes	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
k59_815653_1	1173024.KI912149_gene6518	2.28e-11	70.9	COG0814@1|root,COG0814@2|Bacteria,1G4RP@1117|Cyanobacteria	1117|Cyanobacteria	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_316633_1	1380394.JADL01000007_gene4514	1.11e-30	120.0	COG0642@1|root,COG2205@2|Bacteria,1MW8M@1224|Proteobacteria,2TUSJ@28211|Alphaproteobacteria,2JQSP@204441|Rhodospirillales	204441|Rhodospirillales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
k59_316633_2	1205680.CAKO01000007_gene4410	5.47e-74	228.0	COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria,2TRTZ@28211|Alphaproteobacteria,2JQ2Y@204441|Rhodospirillales	204441|Rhodospirillales	T	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
k59_815659_1	1430440.MGMSRv2_3199	1.39e-44	159.0	COG2992@1|root,COG2992@2|Bacteria,1RD3U@1224|Proteobacteria,2U71B@28211|Alphaproteobacteria,2JS9D@204441|Rhodospirillales	204441|Rhodospirillales	S	FlgJ-related protein	-	-	-	ko:K03796	-	-	-	-	ko00000	-	GH73	-	Glucosaminidase
k59_815662_1	861299.J421_1069	3.8e-09	57.8	COG0594@1|root,COG0594@2|Bacteria,1ZV89@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	rnpA	-	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
k59_815662_2	1313301.AUGC01000001_gene1635	2.49e-15	69.3	COG0230@1|root,COG0230@2|Bacteria,4NUTV@976|Bacteroidetes	976|Bacteroidetes	J	Belongs to the bacterial ribosomal protein bL34 family	rpmH	-	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
k59_929753_1	1096930.L284_14475	4.24e-44	164.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,2TRKI@28211|Alphaproteobacteria,2K00X@204457|Sphingomonadales	204457|Sphingomonadales	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_1429084_2	278957.ABEA03000053_gene1242	8.44e-19	87.4	COG0812@1|root,COG0812@2|Bacteria	2|Bacteria	M	UDP-N-acetylmuramate dehydrogenase activity	murB	GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008762,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0055114,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	1.3.1.98,6.3.2.4	ko:K00075,ko:K01921	ko00473,ko00520,ko00550,ko01100,ko01502,map00473,map00520,map00550,map01100,map01502	-	R01150,R03191,R03192	RC00064,RC00141,RC02639	ko00000,ko00001,ko01000,ko01011	-	-	iIT341.HP1418,iYO844.BSU15230	FAD_binding_4,MurB_C
k59_38447_1	1173024.KI912148_gene3488	4.44e-29	110.0	COG1670@1|root,COG1670@2|Bacteria,1GKPG@1117|Cyanobacteria,1JMI6@1189|Stigonemataceae	1117|Cyanobacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_817487_1	1265313.HRUBRA_01563	3.33e-27	112.0	COG3547@1|root,COG3547@2|Bacteria,1QYJU@1224|Proteobacteria,1RN0A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Transposase IS116 IS110 IS902	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_38448_2	330214.NIDE3060	6.55e-53	176.0	COG2022@1|root,COG2022@2|Bacteria,3J0EI@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S	thiG	-	2.8.1.10	ko:K03149	ko00730,ko01100,map00730,map01100	-	R10247	RC03096,RC03097,RC03461	ko00000,ko00001,ko01000	-	-	-	ThiG
k59_986067_2	471853.Bcav_0929	3.5e-32	122.0	COG0667@1|root,COG0667@2|Bacteria,2GJ4R@201174|Actinobacteria	201174|Actinobacteria	C	aldo keto reductase	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_1429096_1	672.VV93_v1c16360	4.69e-94	286.0	COG2826@1|root,COG2826@2|Bacteria,1MWI0@1224|Proteobacteria,1RRSE@1236|Gammaproteobacteria,1XW0E@135623|Vibrionales	135623|Vibrionales	L	other refs with uncharged polar side chains (S Ser or T Thr), and there are a few more such examples along the aa-chain (ex R Arg changed with H His)	-	-	-	-	-	-	-	-	-	-	-	-	HTH_38,rve
k59_1374305_1	1121033.AUCF01000008_gene5761	5.24e-08	59.7	COG0642@1|root,COG5002@1|root,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,2TXJ2@28211|Alphaproteobacteria,2JPEA@204441|Rhodospirillales	204441|Rhodospirillales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,PAS,PAS_4,PAS_7,Response_reg
k59_1485568_1	1149133.ppKF707_1715	1.23e-61	200.0	COG0639@1|root,COG0639@2|Bacteria,1QE1Y@1224|Proteobacteria,1RRG9@1236|Gammaproteobacteria,1YDJ9@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	T	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
k59_1596608_1	1089550.ATTH01000001_gene686	1.39e-11	70.1	COG0760@1|root,COG0760@2|Bacteria,4NDZZ@976|Bacteroidetes,1FIMM@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	O	SurA N-terminal domain	ppiD	-	5.2.1.8	ko:K01802,ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_2,Rotamase_3,SurA_N_2
k59_1264810_1	555778.Hneap_0431	2.55e-36	142.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1T1IW@1236|Gammaproteobacteria,1WW3B@135613|Chromatiales	135613|Chromatiales	K	sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K10941	ko02020,ko02025,ko05111,map02020,map02025,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	FleQ,HTH_8,Sigma54_activat
k59_428260_1	349521.HCH_01797	2.2e-81	258.0	COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,1RPFB@1236|Gammaproteobacteria,1XHZZ@135619|Oceanospirillales	135619|Oceanospirillales	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
k59_204601_1	290397.Adeh_1435	4.94e-18	87.4	COG0697@1|root,COG0697@2|Bacteria,1RBQS@1224|Proteobacteria,42U3T@68525|delta/epsilon subdivisions,2WQAP@28221|Deltaproteobacteria,2Z2VR@29|Myxococcales	28221|Deltaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_1649644_1	1278073.MYSTI_02092	3.96e-54	193.0	COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,42NH4@68525|delta/epsilon subdivisions,2WN7A@28221|Deltaproteobacteria,2YTZA@29|Myxococcales	28221|Deltaproteobacteria	Q	non-ribosomal peptide synthetase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
k59_986102_1	926550.CLDAP_28000	1.04e-69	224.0	COG0626@1|root,COG0626@2|Bacteria,2G7Q6@200795|Chloroflexi	200795|Chloroflexi	E	PFAM Cys Met metabolism pyridoxal-phosphate-dependent	-	-	4.4.1.11	ko:K01761	ko00270,ko00450,map00270,map00450	-	R00654,R04770	RC00196,RC00348,RC01209,RC01210	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
k59_1206629_1	861299.J421_4544	4.17e-37	137.0	COG0697@1|root,COG0697@2|Bacteria,1ZTM7@142182|Gemmatimonadetes	142182|Gemmatimonadetes	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_94768_1	106582.XP_004558992.1	5.86e-06	53.1	COG2126@1|root,KOG1419@2759|Eukaryota,38BBJ@33154|Opisthokonta,3BA2P@33208|Metazoa,3CR7B@33213|Bilateria,4812D@7711|Chordata,492Q6@7742|Vertebrata,49Y4R@7898|Actinopterygii	33208|Metazoa	P	Potassium voltage-gated channel	KCNQ2	GO:0001700,GO:0002027,GO:0003008,GO:0003012,GO:0003013,GO:0003015,GO:0003674,GO:0005215,GO:0005216,GO:0005244,GO:0005249,GO:0005261,GO:0005267,GO:0005488,GO:0005515,GO:0005516,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0006936,GO:0006941,GO:0007154,GO:0007165,GO:0007186,GO:0007213,GO:0007267,GO:0007268,GO:0007275,GO:0007399,GO:0008015,GO:0008016,GO:0008076,GO:0008092,GO:0008150,GO:0008324,GO:0009719,GO:0009725,GO:0009790,GO:0009792,GO:0009986,GO:0009987,GO:0010033,GO:0015075,GO:0015077,GO:0015079,GO:0015267,GO:0015318,GO:0015672,GO:0016020,GO:0016021,GO:0019226,GO:0022803,GO:0022832,GO:0022836,GO:0022838,GO:0022839,GO:0022843,GO:0022857,GO:0022890,GO:0023052,GO:0030001,GO:0030424,GO:0030506,GO:0031224,GO:0031226,GO:0032501,GO:0032502,GO:0032870,GO:0032991,GO:0033267,GO:0033268,GO:0034220,GO:0034702,GO:0034703,GO:0034705,GO:0035556,GO:0035637,GO:0035690,GO:0042221,GO:0042493,GO:0042995,GO:0043005,GO:0043194,GO:0044057,GO:0044304,GO:0044425,GO:0044459,GO:0044463,GO:0044464,GO:0046873,GO:0047485,GO:0048731,GO:0048856,GO:0050789,GO:0050794,GO:0050877,GO:0050896,GO:0051179,GO:0051234,GO:0051239,GO:0051716,GO:0055085,GO:0060047,GO:0060048,GO:0060359,GO:0065007,GO:0065008,GO:0070887,GO:0071242,GO:0071310,GO:0071495,GO:0071804,GO:0071805,GO:0071944,GO:0095500,GO:0097458,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0098916,GO:0099536,GO:0099537,GO:0120025,GO:0120038,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902495,GO:1903522,GO:1903831,GO:1905144,GO:1905145,GO:1990351	-	ko:K04927,ko:K04929,ko:K04930	ko04725,map04725	-	-	-	ko00000,ko00001,ko04040	1.A.1.15.2,1.A.1.15.4,1.A.1.15.5	-	-	Ion_trans,KCNQ2_u3,KCNQC3-Ank-G_bd,KCNQ_channel
k59_428267_1	1173022.Cri9333_4061	7.81e-71	240.0	COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,1G2UN@1117|Cyanobacteria,1H977@1150|Oscillatoriales	1117|Cyanobacteria	G	Alpha amylase, catalytic domain	-	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	APH,Alpha-amylase,Malt_amylase_C
k59_1429141_1	1329516.JPST01000001_gene998	4.1e-08	55.5	COG1574@1|root,COG1574@2|Bacteria,1TQ6G@1239|Firmicutes,4H9T6@91061|Bacilli,27BP8@186824|Thermoactinomycetaceae	91061|Bacilli	S	Amidohydrolase family	nfdA_1	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_260582_1	1173028.ANKO01000030_gene3274	2.12e-27	115.0	COG0642@1|root,COG4191@1|root,COG2205@2|Bacteria,COG4191@2|Bacteria,1G07W@1117|Cyanobacteria,1H7H2@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9
k59_707733_1	324602.Caur_3090	4.19e-21	94.0	COG3437@1|root,COG3437@2|Bacteria,2GBI7@200795|Chloroflexi,376P2@32061|Chloroflexia	32061|Chloroflexia	T	metal-dependent phosphohydrolase, HD sub domain	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD_5,Response_reg
k59_707733_2	1002340.AFCF01000031_gene4101	2.25e-05	46.6	COG2114@1|root,COG2114@2|Bacteria,1ND4Q@1224|Proteobacteria,2U51W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Protein of unknown function (DUF2652)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2652,Polyketide_cyc2
k59_648967_1	690850.Desaf_1576	1.08e-21	99.4	COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,42M1S@68525|delta/epsilon subdivisions,2WJ02@28221|Deltaproteobacteria,2M8RM@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	TIGRFAM Penicillin-binding protein 2	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	iAF987.Gmet_0928	PBP_dimer,Transpeptidase
k59_594664_1	1333998.M2A_2188	1.49e-75	236.0	COG2834@1|root,COG2834@2|Bacteria,1MXW0@1224|Proteobacteria,2U3UR@28211|Alphaproteobacteria,4BR6M@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	M	Outer membrane lipoprotein-sorting protein	-	-	-	-	-	-	-	-	-	-	-	-	LolA_like
k59_428283_1	177437.HRM2_35950	7.36e-47	162.0	COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,42M84@68525|delta/epsilon subdivisions,2WJ5V@28221|Deltaproteobacteria,2MISN@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
k59_1206650_1	566466.NOR53_3318	6.76e-47	171.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1J4XX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	acrF	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_149648_1	357804.Ping_2678	4.07e-11	64.7	COG4325@1|root,COG4325@2|Bacteria,1MXTM@1224|Proteobacteria,1RNYZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF2254
k59_149648_2	716544.wcw_1764	2.99e-19	88.2	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,2JFDM@204428|Chlamydiae	204428|Chlamydiae	P	Rhodanese Homology Domain	-	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B,Rhodanese
k59_888653_1	290402.Cbei_2652	4.2e-12	68.2	COG0577@1|root,COG0577@2|Bacteria,1TPHU@1239|Firmicutes,247QW@186801|Clostridia,36VPE@31979|Clostridiaceae	186801|Clostridia	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
k59_888671_2	639030.JHVA01000001_gene2511	5.32e-50	166.0	COG4312@1|root,COG4312@2|Bacteria,3Y4MZ@57723|Acidobacteria,2JKEI@204432|Acidobacteriia	204432|Acidobacteriia	S	Bacterial protein of unknown function (DUF899)	-	-	-	-	-	-	-	-	-	-	-	-	DUF899
k59_1056235_1	1120972.AUMH01000010_gene260	1.93e-05	45.4	COG2963@1|root,COG2963@2|Bacteria,1VPYW@1239|Firmicutes,4HZBX@91061|Bacilli	91061|Bacilli	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
k59_1056235_2	545276.KB898737_gene2371	5.39e-16	76.6	COG2801@1|root,COG2801@2|Bacteria	2|Bacteria	L	transposition	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve,rve_3
k59_1610048_1	595537.Varpa_4930	8.05e-20	90.5	COG4962@1|root,COG4962@2|Bacteria,1R7EN@1224|Proteobacteria,2VJWJ@28216|Betaproteobacteria,4ABAY@80864|Comamonadaceae	28216|Betaproteobacteria	U	type II secretion system protein E	-	-	-	ko:K02283,ko:K20527	ko02024,map02024	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.7.4	-	-	FHA,T2SSE,Yop-YscD_cpl
k59_1610048_2	498211.CJA_2579	4.01e-21	94.7	COG0642@1|root,COG0784@1|root,COG2198@1|root,COG2770@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2205@2|Bacteria,COG2770@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1FGI2@10|Cellvibrio	1236|Gammaproteobacteria	T	Histidine Phosphotransfer domain	barA	GO:0000155,GO:0000160,GO:0000302,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009636,GO:0009927,GO:0009987,GO:0010033,GO:0010035,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0035556,GO:0036211,GO:0042221,GO:0042493,GO:0042542,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046677,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007,GO:0070887,GO:0071310,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901700	2.7.13.3	ko:K07678	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	M00475	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF2222,HAMP,HATPase_c,HisKA,Hpt,Response_reg
k59_1443214_1	429009.Adeg_0153	1.45e-28	119.0	COG3039@1|root,COG3039@2|Bacteria,1TPFS@1239|Firmicutes,249JM@186801|Clostridia,42F2V@68295|Thermoanaerobacterales	186801|Clostridia	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_386840_1	398512.JQKC01000022_gene3556	1.45e-65	221.0	COG0480@1|root,COG0480@2|Bacteria,1TPF9@1239|Firmicutes,247VN@186801|Clostridia,3WGEG@541000|Ruminococcaceae	186801|Clostridia	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_216473_1	861299.J421_6359	1.72e-26	112.0	COG0577@1|root,COG0577@2|Bacteria	861299.J421_6359|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_272978_1	1687.BCOR_0108	1.39e-11	65.5	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,4CZ24@85004|Bifidobacteriales	201174|Actinobacteria	P	E1-E2 ATPase	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	Cupredoxin_1,E1-E2_ATPase,HMA,Hydrolase,YHS
k59_272978_2	984262.SGRA_0363	7.18e-08	55.8	COG0607@1|root,COG0607@2|Bacteria,4NUPH@976|Bacteroidetes,1IU89@117747|Sphingobacteriia	976|Bacteroidetes	P	COG0607 Rhodanese-related sulfurtransferase	glpE	-	-	-	-	-	-	-	-	-	-	-	Rhodanese,Thioredoxin
k59_272978_3	1229909.NSED_04560	0.000318	45.8	COG1651@1|root,arCOG02868@2157|Archaea,41T2A@651137|Thaumarchaeota	651137|Thaumarchaeota	O	DSBA-like thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
k59_606685_1	485917.Phep_1474	1.5e-23	99.0	COG0178@1|root,COG0178@2|Bacteria,4NJCU@976|Bacteroidetes,1INT4@117747|Sphingobacteriia	976|Bacteroidetes	L	pfam abc	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
k59_606685_2	1123320.KB889664_gene1221	7.52e-31	112.0	COG5646@1|root,COG5646@2|Bacteria,2IINN@201174|Actinobacteria	201174|Actinobacteria	S	InterPro IPR014922	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
k59_831650_1	926569.ANT_28320	4.97e-111	352.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1146@2|Bacteria,2G5M1@200795|Chloroflexi	200795|Chloroflexi	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	porA	-	1.2.7.1	ko:K00169,ko:K03737	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034,R10866	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,Fer4_6,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_888709_1	314271.RB2654_13770	4.94e-78	256.0	COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	TRAP-type mannitol chloroaromatic compound transport system large permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_1663552_1	1459636.NTE_01403	1.79e-58	194.0	COG2132@1|root,arCOG03914@2157|Archaea,41SZT@651137|Thaumarchaeota	651137|Thaumarchaeota	Q	Multicopper oxidase	-	-	1.7.2.1	ko:K00368	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Cu-oxidase_3
k59_1219412_1	1048339.KB913029_gene2788	2.58e-17	85.9	COG0787@1|root,COG0787@2|Bacteria,2GM2Y@201174|Actinobacteria,4ERH5@85013|Frankiales	201174|Actinobacteria	E	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
k59_216506_1	999419.HMPREF1077_02798	8.61e-23	102.0	COG0457@1|root,COG0457@2|Bacteria,4NERG@976|Bacteroidetes,2FMK5@200643|Bacteroidia,22X3E@171551|Porphyromonadaceae	976|Bacteroidetes	S	Oxygen tolerance	batD	-	-	-	-	-	-	-	-	-	-	-	BatD,TPR_2
k59_1389718_1	880072.Desac_2709	1.29e-111	341.0	COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,42NYT@68525|delta/epsilon subdivisions,2WIM3@28221|Deltaproteobacteria,2MQVI@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
k59_273017_1	1123256.KB907929_gene3367	4.23e-40	140.0	COG1876@1|root,COG1876@2|Bacteria,1N1CQ@1224|Proteobacteria,1SASN@1236|Gammaproteobacteria,1X577@135614|Xanthomonadales	135614|Xanthomonadales	M	D-alanyl-D-alanine carboxypeptidase	-	-	3.4.17.14	ko:K07260	ko00550,ko01100,ko01502,ko02020,map00550,map01100,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	-	-	-	VanY
k59_386883_1	204669.Acid345_1270	3.75e-77	247.0	COG1233@1|root,COG1233@2|Bacteria,3Y3T3@57723|Acidobacteria,2JME5@204432|Acidobacteriia	204432|Acidobacteriia	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_8
k59_108160_1	1121324.CLIT_4c00250	2.13e-11	69.3	COG0475@1|root,COG0569@1|root,COG0475@2|Bacteria,COG0569@2|Bacteria,1TS32@1239|Firmicutes,247XW@186801|Clostridia,25RVB@186804|Peptostreptococcaceae	186801|Clostridia	P	CPA2 family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
k59_1776492_1	861299.J421_3561	2.75e-78	253.0	COG0556@1|root,COG0556@2|Bacteria,1ZSQS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
k59_888777_2	867845.KI911784_gene152	1.48e-29	119.0	COG4962@1|root,COG4962@2|Bacteria,2G68E@200795|Chloroflexi,374Z4@32061|Chloroflexia	32061|Chloroflexia	U	PFAM type II secretion system protein E	-	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
k59_1610135_1	1242864.D187_005825	4.39e-36	133.0	COG0739@1|root,COG0739@2|Bacteria,1MY2X@1224|Proteobacteria,42U06@68525|delta/epsilon subdivisions,2WQXU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_998478_1	1894.JOER01000010_gene2175	1.75e-80	253.0	COG0044@1|root,COG0044@2|Bacteria,2GK4A@201174|Actinobacteria	201174|Actinobacteria	F	Dihydropyrimidinase	hydA	-	3.5.2.2	ko:K01464	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R02269,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Amidohydro_1
k59_1443329_1	648996.Theam_0353	4.02e-17	76.6	COG1254@1|root,COG1254@2|Bacteria,2G49Q@200783|Aquificae	200783|Aquificae	C	Belongs to the acylphosphatase family	-	-	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
k59_1443329_2	525264.HMPREF0305_10519	1.97e-25	103.0	COG0266@1|root,COG0266@2|Bacteria,2GJNT@201174|Actinobacteria,22K5T@1653|Corynebacteriaceae	201174|Actinobacteria	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	GO:0000702,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006979,GO:0008150,GO:0008152,GO:0008534,GO:0009987,GO:0016020,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034039,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
k59_606764_2	1167006.UWK_00654	1.85e-07	52.0	COG4584@1|root,COG4584@2|Bacteria,1MU2G@1224|Proteobacteria,42N2X@68525|delta/epsilon subdivisions,2X7GJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Sigma-70, region 4	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_1443332_1	1454004.AW11_03037	2.87e-21	96.7	COG0025@1|root,COG0025@2|Bacteria,1QTUE@1224|Proteobacteria	1224|Proteobacteria	P	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
k59_1776541_1	690850.Desaf_2482	1.8e-07	54.7	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria,2M7WE@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
k59_1776541_2	448385.sce4570	0.0005	43.1	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,42MW3@68525|delta/epsilon subdivisions,2WJRZ@28221|Deltaproteobacteria,2YW7G@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2101	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_164359_2	1408433.JHXV01000012_gene4004	1.05e-06	50.8	COG0607@1|root,COG0607@2|Bacteria,4NSD1@976|Bacteroidetes,1I4FW@117743|Flavobacteriia,2PC1E@246874|Cryomorphaceae	976|Bacteroidetes	P	PFAM Rhodanese-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_108210_1	649831.L083_4644	2.18e-41	147.0	COG0596@1|root,COG0596@2|Bacteria,2IFCI@201174|Actinobacteria,4DC31@85008|Micromonosporales	201174|Actinobacteria	S	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
k59_606775_2	743721.Psesu_1045	1.09e-42	155.0	COG1874@1|root,COG1874@2|Bacteria,1P0Y5@1224|Proteobacteria,1RZHZ@1236|Gammaproteobacteria,1X4DM@135614|Xanthomonadales	135614|Xanthomonadales	G	glycoside hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_35,Glyco_hydro_42
k59_888837_1	247634.GPB2148_2551	8.98e-49	168.0	COG2141@1|root,COG2141@2|Bacteria,1R9CH@1224|Proteobacteria,1RZ9F@1236|Gammaproteobacteria,1J57F@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_888837_3	883077.HMPREF9241_00961	7.38e-49	171.0	COG0820@1|root,COG0820@2|Bacteria,2GJ48@201174|Actinobacteria,4D3E7@85005|Actinomycetales	201174|Actinobacteria	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030312,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Radical_SAM
k59_662341_1	926550.CLDAP_26100	1.41e-74	228.0	COG3415@1|root,COG3415@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_28,HTH_32,HTH_33
k59_386946_1	903818.KI912268_gene3360	4.72e-42	157.0	COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,3Y3IC@57723|Acidobacteria	57723|Acidobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K11527	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	GAF_2,HATPase_c,HisKA,Hpt,PAS_9,Response_reg
k59_1389832_1	696281.Desru_2442	1.27e-62	210.0	COG4988@1|root,COG4988@2|Bacteria,1TQ1P@1239|Firmicutes,248SV@186801|Clostridia,2612P@186807|Peptococcaceae	186801|Clostridia	CO	Cysteine export CydDC family ABC transporter permease subunit ATP-binding protein CydD	cydD	-	-	ko:K06148,ko:K16013	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1,3.A.1.129	-	-	ABC_membrane,ABC_tran
k59_888853_1	1316936.K678_04637	1.08e-60	208.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,2TQTB@28211|Alphaproteobacteria,2JQ5G@204441|Rhodospirillales	204441|Rhodospirillales	T	COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation	ntrY	-	2.7.13.3	ko:K13598	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4
k59_774310_1	324602.Caur_3096	1.32e-24	108.0	COG1197@1|root,COG1197@2|Bacteria,2G5UW@200795|Chloroflexi,375DR@32061|Chloroflexia	32061|Chloroflexia	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_386950_1	671143.DAMO_3137	2.91e-51	167.0	COG0597@1|root,COG0597@2|Bacteria,2NPU1@2323|unclassified Bacteria	2|Bacteria	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
k59_1219506_2	1157637.KB892155_gene7563	0.000334	47.8	COG0591@1|root,COG0591@2|Bacteria,2GKPW@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
k59_1110461_1	1111732.AZOD01000030_gene1378	2.24e-24	105.0	COG2010@1|root,COG2010@2|Bacteria,1MV6D@1224|Proteobacteria,1RMYF@1236|Gammaproteobacteria,1X4BN@135614|Xanthomonadales	135614|Xanthomonadales	C	Cytochrome c, mono-and diheme variants family	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
k59_52290_1	1125863.JAFN01000001_gene1350	1.42e-64	215.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,42N7V@68525|delta/epsilon subdivisions,2WJWF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	3-octaprenyl-4-hydroxybenzoate carboxy-lyase	-	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
k59_276210_2	1540221.JQNI01000002_gene2285	1.46e-10	61.6	COG0022@1|root,COG0022@2|Bacteria,1WINY@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Pyruvate 2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit	-	-	1.2.4.4	ko:K00167	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
k59_276222_1	1157708.KB907450_gene6422	5.55e-54	180.0	COG3777@1|root,COG3777@2|Bacteria,1P96N@1224|Proteobacteria,2VIUS@28216|Betaproteobacteria,4AAUD@80864|Comamonadaceae	28216|Betaproteobacteria	S	N-terminal half of MaoC dehydratase	-	-	4.2.1.153,4.2.1.56	ko:K09709,ko:K18291	ko00660,ko00720,ko01120,ko01200,map00660,map00720,map01120,map01200	M00376	R02491,R09282	RC00730,RC02479	ko00000,ko00001,ko00002,ko01000	-	-	-	MaoC_dehydrat_N
k59_777958_1	1120948.KB903229_gene5164	7.72e-57	189.0	COG0620@1|root,COG0620@2|Bacteria,2H8H4@201174|Actinobacteria,4E8PX@85010|Pseudonocardiales	2|Bacteria	E	Methionine synthase	metE2	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
k59_219642_1	237368.SCABRO_02000	1.07e-06	47.8	COG0713@1|root,COG0713@2|Bacteria,2J0GU@203682|Planctomycetes	203682|Planctomycetes	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	-	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
k59_219642_2	1306174.JODP01000006_gene3496	5.33e-16	79.7	COG0839@1|root,COG0839@2|Bacteria,2GKRS@201174|Actinobacteria	201174|Actinobacteria	C	Belongs to the complex I subunit 6 family	nuoJ	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
k59_777983_1	644548.SCNU_09251	8.34e-09	61.6	COG1024@1|root,COG1024@2|Bacteria,2GKJ6@201174|Actinobacteria,4GA5Q@85026|Gordoniaceae	201174|Actinobacteria	I	Enoyl-CoA hydratase/isomerase	echA19	GO:0003674,GO:0003824,GO:0004300,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
k59_276262_1	1396418.BATQ01000016_gene4252	3.36e-50	167.0	COG0406@1|root,COG0406@2|Bacteria,46T4J@74201|Verrucomicrobia,2IV5M@203494|Verrucomicrobiae	203494|Verrucomicrobiae	G	Phosphoglycerate mutase family	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
k59_1222813_1	1120949.KB903301_gene6369	9.64e-116	337.0	COG3618@1|root,COG3618@2|Bacteria,2IB8W@201174|Actinobacteria,4DJ63@85008|Micromonosporales	201174|Actinobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
k59_610082_1	1136417.AZWE01000015_gene1538	7.84e-25	110.0	COG0477@1|root,COG2814@2|Bacteria,2GJU2@201174|Actinobacteria,4DBGR@85008|Micromonosporales	201174|Actinobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
k59_610098_2	439235.Dalk_2026	5.87e-20	92.4	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,42P7V@68525|delta/epsilon subdivisions,2WJQA@28221|Deltaproteobacteria,2MJ2Q@213118|Desulfobacterales	28221|Deltaproteobacteria	V	ABC-2 family transporter protein	ybhS	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_3
k59_1222830_1	985665.HPL003_20090	1.41e-06	54.3	COG1974@1|root,COG1974@2|Bacteria,1TQ3H@1239|Firmicutes,4HBHA@91061|Bacilli,26RDN@186822|Paenibacillaceae	91061|Bacilli	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031668,GO:0032991,GO:0032993,GO:0033554,GO:0043565,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
k59_276318_1	1123392.AQWL01000004_gene2790	1.82e-05	52.4	COG3164@1|root,COG3164@2|Bacteria,1MXWF@1224|Proteobacteria,2VH52@28216|Betaproteobacteria,1KS47@119069|Hydrogenophilales	119069|Hydrogenophilales	S	Protein of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	AsmA_2,DUF3971
k59_666056_2	485913.Krac_7418	1.04e-75	230.0	COG0262@1|root,COG0262@2|Bacteria	2|Bacteria	H	dihydrofolate reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
k59_219757_1	1459636.NTE_02911	1.23e-17	82.0	COG0459@1|root,arCOG01257@2157|Archaea,41SDG@651137|Thaumarchaeota	2157|Archaea	O	PFAM TCP-1 cpn60 chaperonin family	thsA	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0044183,GO:0051082,GO:0061077	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
k59_1222920_1	1160718.SU9_26459	8.71e-27	114.0	COG0318@1|root,COG0318@2|Bacteria,2GJR0@201174|Actinobacteria	201174|Actinobacteria	IQ	synthetase	-	-	6.1.3.1	ko:K22319	-	-	-	-	ko00000,ko01000	-	-	-	AMP-binding,Abhydrolase_1
k59_1222924_1	1380355.JNIJ01000109_gene5339	8.44e-80	247.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2TSA7@28211|Alphaproteobacteria,3JTRC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_1555409_1	1123277.KB893206_gene3406	8.05e-19	83.2	COG3324@1|root,COG3324@2|Bacteria,4NMFV@976|Bacteroidetes,47S1F@768503|Cytophagia	976|Bacteroidetes	S	Glyoxalase-like domain	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
k59_276400_1	1123229.AUBC01000005_gene735	0.000574	46.6	COG3090@1|root,COG3090@2|Bacteria,1RA8Q@1224|Proteobacteria,2U67A@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	TRAP-type C4-dicarboxylate transport system small permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
k59_1667406_1	1280689.AUJC01000011_gene1572	6.61e-07	52.0	COG0129@1|root,COG0129@2|Bacteria,1TP1R@1239|Firmicutes,247UC@186801|Clostridia,36DS1@31979|Clostridiaceae	186801|Clostridia	EG	Belongs to the IlvD Edd family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
k59_610252_1	1229204.AMYY01000007_gene1203	3.04e-40	154.0	COG4122@1|root,COG4122@2|Bacteria,1QWCT@1224|Proteobacteria,2TYCV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_219879_1	744980.TRICHSKD4_1741	1.16e-72	243.0	COG0506@1|root,COG4230@1|root,COG0506@2|Bacteria,COG4230@2|Bacteria,1MV93@1224|Proteobacteria,2TQPT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Oxidizes proline to glutamate for use as a carbon and nitrogen source	putA	-	1.2.1.88,1.5.5.2	ko:K13821	ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130	-	R00245,R00707,R00708,R01253,R04444,R04445,R05051	RC00080,RC00083,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000,ko03000	-	-	-	Aldedh,Pro_dh,Pro_dh-DNA_bdg
k59_610282_1	566466.NOR53_3441	7.07e-99	303.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,1S01K@1236|Gammaproteobacteria,1J7W3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	L COG3666 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_219903_1	671143.DAMO_2785	3.76e-90	272.0	COG0115@1|root,COG0115@2|Bacteria,2NP1Q@2323|unclassified Bacteria	2|Bacteria	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
k59_666220_1	525903.Taci_0806	1.29e-25	99.4	COG0691@1|root,COG0691@2|Bacteria,3TAY0@508458|Synergistetes	508458|Synergistetes	J	the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
k59_276535_1	1123355.JHYO01000005_gene893	3.01e-15	80.9	COG2304@1|root,COG2911@1|root,COG2931@1|root,COG3210@1|root,COG2304@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,36ZVS@31993|Methylocystaceae	28211|Alphaproteobacteria	Q	Haemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind,Hint_2,PA14
k59_778313_1	319236.JCM19294_1879	3.06e-23	95.5	COG1024@1|root,COG1024@2|Bacteria,4NEH4@976|Bacteroidetes,1HXB6@117743|Flavobacteriia,3HJTZ@363408|Nonlabens	976|Bacteroidetes	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.18	ko:K13766	ko00280,ko01100,map00280,map01100	M00036	R02085	RC02416	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
k59_778313_2	1197477.IA57_02085	2.87e-71	229.0	COG0508@1|root,COG0508@2|Bacteria,4NED0@976|Bacteroidetes,1HYJX@117743|Flavobacteriia	976|Bacteroidetes	C	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex	pdhC	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_666228_1	715451.ambt_14960	3.83e-75	241.0	COG0457@1|root,COG0457@2|Bacteria,1Q3YA@1224|Proteobacteria,1RN2D@1236|Gammaproteobacteria,46595@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Peptidase family M49	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M49
k59_276552_1	331869.BAL199_15703	3.47e-09	57.0	COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,2TRXK@28211|Alphaproteobacteria,4BPP4@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	GO:0003674,GO:0003824,GO:0004774,GO:0004775,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016874,GO:0016877,GO:0016878,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
k59_276552_2	1121861.KB899917_gene3596	1.38e-90	273.0	COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,2TQKB@28211|Alphaproteobacteria,2JPJ9@204441|Rhodospirillales	204441|Rhodospirillales	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
## 14223 queries scanned
## Total time (seconds): 215.27424693107605
## Rate: 66.07 q/s