## Fri Jan 3 02:46:45 2025 ## emapper-2.1.12 ## /data/home/zhuyingjie/miniforge3/envs/eggnog/bin/emapper.py -i /data/home/zhuyingjie/01_Project/01_metagenome/mangrove/mmseqs_cluster/PRJNA947344/SRR24201525/SRR24201525_p_cluster_rep_seq.fasta --output PRJNA947344_SRR24201525 --data_dir /data/software/eggnog_database -m diamond --sensmode fast --output_dir /data/home/zhuyingjie/01_Project/01_metagenome/mangrove/annotation --temp_dir /data/software/eggnog_database/temp --excel --dbmem --cpu 24 ## #query seed_ortholog evalue score eggNOG_OGs max_annot_lvl COG_category Description Preferred_name GOs EC KEGG_ko KEGG_Pathway KEGG_Module KEGG_Reaction KEGG_rclass BRITE KEGG_TC CAZy BiGG_Reaction PFAMs k59_431047_1 446468.Ndas_2257 1.56e-13 75.9 COG1052@1|root,COG1052@2|Bacteria,2HFW8@201174|Actinobacteria,4EPNJ@85012|Streptosporangiales 201174|Actinobacteria C D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain - - - - - - - - - - - - 2-Hacid_dh,2-Hacid_dh_C k59_1283328_1 335659.S23_18570 8.25e-35 125.0 COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2TSA6@28211|Alphaproteobacteria,3JUSQ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E ATPases associated with a variety of cellular activities MA20_02445 - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran k59_1283328_2 224911.27354757 2.37e-44 151.0 COG0411@1|root,COG0411@2|Bacteria,1MVAU@1224|Proteobacteria,2TVRN@28211|Alphaproteobacteria,3JW0T@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Branched-chain amino acid ATP-binding cassette transporter MA20_02440 - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_48050_1 570952.ATVH01000015_gene1382 4.64e-45 157.0 COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,2TS7B@28211|Alphaproteobacteria,2JQR2@204441|Rhodospirillales 204441|Rhodospirillales L Transposase - - - - - - - - - - - - DDE_Tnp_1,DUF772 k59_814048_1 1266925.JHVX01000010_gene1337 1.08e-60 203.0 COG2027@1|root,COG2027@2|Bacteria,1MW40@1224|Proteobacteria,2VH20@28216|Betaproteobacteria,3726P@32003|Nitrosomonadales 28216|Betaproteobacteria M PFAM Peptidase S13, D-Ala-D-Ala carboxypeptidase C dacB - 3.4.16.4 ko:K07259 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - Peptidase_S13 k59_89613_1 631454.N177_0417 1.11e-85 265.0 COG2224@1|root,COG2224@2|Bacteria,1MWIF@1224|Proteobacteria,2TU0Q@28211|Alphaproteobacteria,1JN2Y@119043|Rhodobiaceae 28211|Alphaproteobacteria C Phosphoenolpyruvate phosphomutase aceA - 4.1.3.1 ko:K01637 ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200 M00012 R00479 RC00311,RC00313 ko00000,ko00001,ko00002,ko01000 - - - ICL,PEP_mutase k59_985177_1 1121377.KB906400_gene1245 2.49e-141 416.0 COG0554@1|root,COG0554@2|Bacteria,1WI6Q@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus C Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate glpK GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 - R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 - - - FGGY_C,FGGY_N k59_1283368_1 261292.Nit79A3_3121 2.47e-50 177.0 COG0557@1|root,COG0557@2|Bacteria,1NGSQ@1224|Proteobacteria,2VHMM@28216|Betaproteobacteria,3721E@32003|Nitrosomonadales 28216|Betaproteobacteria K ribonuclease II rnb - 3.1.13.1 ko:K01147 - - - - ko00000,ko01000,ko03016 - - - RNB k59_1029131_2 1392838.AWNM01000038_gene969 4.65e-125 369.0 COG0809@1|root,COG0809@2|Bacteria,1MUH3@1224|Proteobacteria,2VHJF@28216|Betaproteobacteria,3T1KD@506|Alcaligenaceae 28216|Betaproteobacteria J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) queA GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 ko:K07568 - - - - ko00000,ko01000,ko03016 - - - Queuosine_synth k59_1241002_1 1223521.BBJX01000001_gene818 1.3e-84 258.0 COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,2W0NK@28216|Betaproteobacteria,4ACNQ@80864|Comamonadaceae 28216|Betaproteobacteria P Belongs to the ABC transporter superfamily - - - ko:K02031 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_1029219_1 292459.STH1159 5.81e-33 120.0 COG0817@1|root,COG0817@2|Bacteria,1V3N9@1239|Firmicutes,24HMI@186801|Clostridia 186801|Clostridia L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group ruvC - 3.1.22.4 ko:K01159 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvC k59_942608_2 1195246.AGRI_05117 1.48e-29 120.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RPM5@1236|Gammaproteobacteria,4657E@72275|Alteromonadaceae 1236|Gammaproteobacteria I COG1960 Acyl-CoA dehydrogenases fadE GO:0003674,GO:0003824,GO:0003995,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016491,GO:0016627,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:1901575 - ko:K06445 ko00071,ko01100,ko01212,map00071,map01100,map01212 M00087 R01175,R01279,R03777,R03857,R03990,R04751,R04754 RC00052,RC00076 ko00000,ko00001,ko00002,ko01000 - - iSbBS512_1146.SbBS512_E0217 Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,DUF1974 k59_729517_1 1005048.CFU_3565 7.31e-16 75.1 COG0350@1|root,COG0350@2|Bacteria,1RGB5@1224|Proteobacteria,2VRHP@28216|Betaproteobacteria,478VI@75682|Oxalobacteraceae 28216|Betaproteobacteria H 6-O-methylguanine DNA methyltransferase, DNA binding domain ogt - 2.1.1.63 ko:K00567 - - - - ko00000,ko01000,ko03400 - - - DNA_binding_1 k59_729517_2 713586.KB900536_gene702 1.22e-104 314.0 COG2055@1|root,COG2055@2|Bacteria,1MWQY@1224|Proteobacteria,1RRSU@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the LDH2 MDH2 oxidoreductase family comC - 1.1.1.338,1.5.1.21 ko:K13609,ko:K16844 ko00270,ko00310,ko00960,ko01100,ko01120,map00270,map00310,map00960,map01100,map01120 - R02203,R07137 RC00031,RC00135 ko00000,ko00001,ko01000 - - - Ldh_2 k59_729537_2 1206735.BAGG01000095_gene4152 8.84e-05 51.2 COG0596@1|root,COG0596@2|Bacteria,2I8EU@201174|Actinobacteria,4FWB1@85025|Nocardiaceae 201174|Actinobacteria S Serine aminopeptidase, S33 lipV GO:0003674,GO:0003824,GO:0005488,GO:0005504,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008289,GO:0009056,GO:0009062,GO:0009268,GO:0009628,GO:0009987,GO:0010447,GO:0016042,GO:0016054,GO:0016298,GO:0016787,GO:0016788,GO:0019752,GO:0031406,GO:0032787,GO:0033293,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0050896,GO:0051716,GO:0071214,GO:0071467,GO:0071468,GO:0071704,GO:0072329,GO:0104004,GO:1901575 - ko:K19311 - - - - ko00000,ko01000 - - - Abhydrolase_1,Abhydrolase_6 k59_729537_3 196490.AUEZ01000046_gene6768 3.35e-05 45.1 COG1017@1|root,COG1017@2|Bacteria,1QVJP@1224|Proteobacteria,2U5M6@28211|Alphaproteobacteria,3JY65@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Belongs to the globin family MA20_17055 - 1.14.12.17 ko:K05916 ko05132,map05132 - - - ko00000,ko00001,ko01000 - - - Globin k59_1326922_1 709797.CSIRO_1195 4.26e-39 145.0 COG2358@1|root,COG2358@2|Bacteria,1MXW1@1224|Proteobacteria,2TSK2@28211|Alphaproteobacteria,3JSVJ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S NMT1-like family - - - ko:K07080 - - - - ko00000 - - - NMT1_3 k59_89767_1 1380394.JADL01000008_gene3614 2.79e-68 232.0 COG0506@1|root,COG4230@1|root,COG0506@2|Bacteria,COG4230@2|Bacteria,1MV93@1224|Proteobacteria,2TQPT@28211|Alphaproteobacteria,2JPKY@204441|Rhodospirillales 204441|Rhodospirillales CE Oxidizes proline to glutamate for use as a carbon and nitrogen source putA - 1.2.1.88,1.5.5.2 ko:K13821 ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130 - R00245,R00707,R00708,R01253,R04444,R04445,R05051 RC00080,RC00083,RC00216,RC00242,RC00255 ko00000,ko00001,ko01000,ko03000 - - - Aldedh,Pro_dh,Pro_dh-DNA_bdg k59_1326941_1 1054213.HMPREF9946_00954 7.23e-05 45.1 COG0696@1|root,COG0696@2|Bacteria,1MUQ1@1224|Proteobacteria,2TS6R@28211|Alphaproteobacteria,2JR4Y@204441|Rhodospirillales 204441|Rhodospirillales G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate gpmI - 5.4.2.12 ko:K15633 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - Metalloenzyme,Phosphodiest,iPGM_N k59_260290_2 1485545.JQLW01000008_gene1984 2.3e-40 147.0 COG0615@1|root,COG0615@2|Bacteria,1N9T6@1224|Proteobacteria 1224|Proteobacteria IM Sulfotransferase family - - - - - - - - - - - - Sulfotransfer_3 k59_175520_1 109871.XP_006676525.1 1.86e-33 133.0 COG0139@1|root,COG0141@1|root,KOG2697@2759|Eukaryota,KOG4311@2759|Eukaryota,38HWK@33154|Opisthokonta,3NURS@4751|Fungi 4751|Fungi E Histidine biosynthesis trifunctional protein HIS4 GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0004635,GO:0004636,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016462,GO:0016491,GO:0016614,GO:0016616,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23,3.5.4.19,3.6.1.31 ko:K14152 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012,R04035,R04037 RC00002,RC00099,RC00242,RC00463,RC01055 ko00000,ko00001,ko00002,ko01000 - - - Histidinol_dh,PRA-CH,PRA-PH k59_473846_1 1380355.JNIJ01000050_gene136 2.82e-46 169.0 COG0348@1|root,COG3889@1|root,COG0348@2|Bacteria,COG3889@2|Bacteria,1R9JQ@1224|Proteobacteria,2U3WR@28211|Alphaproteobacteria,3K36U@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C domain, Protein - - - - - - - - - - - - - k59_686974_1 1454004.AW11_03721 1.51e-29 117.0 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,2VJMF@28216|Betaproteobacteria,1KQ8U@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_132338_1 76114.ebA2525 2.93e-30 116.0 COG1943@1|root,COG1943@2|Bacteria,1P19I@1224|Proteobacteria,2VKZ3@28216|Betaproteobacteria,2KX0Z@206389|Rhodocyclales 206389|Rhodocyclales L Transposase IS200 like - - - ko:K07491 - - - - ko00000 - - - Y1_Tnp k59_218050_1 301.JNHE01000022_gene2592 4.43e-46 152.0 COG4454@1|root,COG4454@2|Bacteria,1R91G@1224|Proteobacteria,1S5Y8@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Copper binding proteins, plastocyanin/azurin family - - - - - - - - - - - - Copper-bind,Cupredoxin_1 k59_218050_2 365044.Pnap_1260 1.12e-20 90.1 COG4454@1|root,COG5569@1|root,COG4454@2|Bacteria,COG5569@2|Bacteria,1R91G@1224|Proteobacteria,2VSDP@28216|Betaproteobacteria,4AED8@80864|Comamonadaceae 28216|Betaproteobacteria P PFAM Blue (type 1) copper domain - - - - - - - - - - - - Copper-bind,Cupredoxin_1,CusF_Ec k59_175557_1 196367.JNFG01000214_gene1294 1.77e-30 120.0 COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,2VNSH@28216|Betaproteobacteria,1KGQD@119060|Burkholderiaceae 28216|Betaproteobacteria L Phage integrase, N-terminal SAM-like domain - - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_4,Phage_integrase k59_942779_1 247633.GP2143_05985 2.91e-23 98.6 28HKI@1|root,2Z7VC@2|Bacteria,1MW0I@1224|Proteobacteria,1RQ5H@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_942779_2 1123236.KB899377_gene312 5.01e-20 89.0 COG2133@1|root,COG2133@2|Bacteria,1R74P@1224|Proteobacteria,1RSG0@1236|Gammaproteobacteria,4676D@72275|Alteromonadaceae 1236|Gammaproteobacteria G Carbohydrate family 9 binding domain-like - - - - - - - - - - - - CBM9_1 k59_1241233_1 754477.Q7C_449 1.2e-47 173.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,45ZZR@72273|Thiotrichales 72273|Thiotrichales T Diguanylate cyclase - - - - - - - - - - - - EAL,GAF_2,GGDEF,PAS_9 k59_1283611_1 391937.NA2_01000 6.08e-68 218.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TUX3@28211|Alphaproteobacteria,43JBR@69277|Phyllobacteriaceae 28211|Alphaproteobacteria I Belongs to the thiolase family MA20_44850 - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_1283611_2 477184.KYC_27748 1.91e-08 56.6 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VKIW@28216|Betaproteobacteria,3T1CY@506|Alcaligenaceae 28216|Betaproteobacteria I Acyl-CoA dehydrogenases fadE - - ko:K06445 ko00071,ko01100,ko01212,map00071,map01100,map01212 M00087 R01175,R01279,R03777,R03857,R03990,R04751,R04754 RC00052,RC00076 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,DUF1974 k59_1029456_1 861299.J421_5991 3.71e-23 102.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1283626_1 1265502.KB905964_gene1374 3.86e-139 418.0 COG4231@1|root,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2VK1K@28216|Betaproteobacteria,4AASY@80864|Comamonadaceae 28216|Betaproteobacteria C Indolepyruvate ferredoxin oxidoreductase - - 1.2.7.8 ko:K00179 - - - - br01601,ko00000,ko01000 - - - TPP_enzyme_C k59_175628_1 557598.LHK_03217 5.76e-44 153.0 COG0730@1|root,COG0730@2|Bacteria,1R3V4@1224|Proteobacteria,2VKXN@28216|Betaproteobacteria,2KQBS@206351|Neisseriales 206351|Neisseriales S membrane transporter protein - - - ko:K07090 - - - - ko00000 - - - TauE k59_1072028_1 298653.Franean1_4711 3.9e-15 75.1 COG1319@1|root,COG1319@2|Bacteria,2GP37@201174|Actinobacteria,4EUCN@85013|Frankiales 201174|Actinobacteria C CO dehydrogenase flavoprotein C-terminal domain - - 1.2.5.3 ko:K03519 - - R11168 RC02800 ko00000,ko01000 - - - CO_deh_flav_C,FAD_binding_5 k59_1072028_2 331869.BAL199_04969 5.99e-11 60.8 COG0789@1|root,COG0789@2|Bacteria,1MZ3P@1224|Proteobacteria,2UC95@28211|Alphaproteobacteria 28211|Alphaproteobacteria K transcriptional regulator merR - - ko:K08365 - - - - ko00000,ko03000 - - - MerR,MerR-DNA-bind,MerR_1 k59_729712_1 713587.THITH_11720 1.11e-21 94.7 COG1921@1|root,COG1921@2|Bacteria,1MWXI@1224|Proteobacteria,1RN73@1236|Gammaproteobacteria,1X014@135613|Chromatiales 135613|Chromatiales H Selenocysteine synthase N terminal - - 2.9.1.1 ko:K01042 ko00450,ko00970,map00450,map00970 - R08219 RC01246 ko00000,ko00001,ko01000 - - - Se-cys_synth_N,SelA k59_729712_2 1469245.JFBG01000037_gene1849 1.86e-42 153.0 COG3276@1|root,COG3276@2|Bacteria,1MWXH@1224|Proteobacteria,1RQJI@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Translation elongation factor selB GO:0000049,GO:0000166,GO:0001514,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006412,GO:0006414,GO:0006417,GO:0006451,GO:0006518,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009069,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016259,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031326,GO:0032268,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034248,GO:0034641,GO:0034645,GO:0035368,GO:0035639,GO:0036094,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:2000112 - ko:K03833 - - - - ko00000,ko03012 - - - GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3 k59_687119_1 1205680.CAKO01000038_gene1694 2.71e-79 253.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TR1I@28211|Alphaproteobacteria,2JPQC@204441|Rhodospirillales 204441|Rhodospirillales E COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_773039_1 395019.Bmul_2222 6.8e-71 228.0 COG0312@1|root,COG0312@2|Bacteria,1MUVW@1224|Proteobacteria,2VHJ4@28216|Betaproteobacteria,1K0SS@119060|Burkholderiaceae 28216|Betaproteobacteria S PFAM peptidase U62 modulator of DNA gyrase pmbA - - ko:K03592 - - - - ko00000,ko01002 - - - PmbA_TldD k59_1029536_1 443598.AUFA01000014_gene6964 1.44e-104 309.0 COG1024@1|root,COG1024@2|Bacteria,1MVEC@1224|Proteobacteria,2TRPS@28211|Alphaproteobacteria,3JREH@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I Enoyl-CoA hydratase/isomerase MA20_40175 - 4.2.1.18,4.2.1.57 ko:K13766,ko:K13779 ko00280,ko00281,ko01100,map00280,map00281,map01100 M00036 R02085,R03493 RC00941,RC02416 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_1029536_2 1280952.HJA_13600 9.02e-09 60.1 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2TSME@28211|Alphaproteobacteria 28211|Alphaproteobacteria E gamma-glutamyltransferase - - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_1156076_2 398527.Bphyt_4942 7.39e-49 167.0 COG3302@1|root,COG3302@2|Bacteria,1MWY1@1224|Proteobacteria,2VN4W@28216|Betaproteobacteria,1K58I@119060|Burkholderiaceae 28216|Betaproteobacteria S DMSO reductase dmsC - - ko:K21309 ko00920,ko01100,ko01120,map00920,map01100,map01120 - R11487 RC00168 ko00000,ko00001 - - - DmsC k59_132503_1 1550073.JROH01000006_gene1510 3.93e-104 323.0 COG1506@1|root,COG1506@2|Bacteria,1MUJ3@1224|Proteobacteria,2TUZZ@28211|Alphaproteobacteria,2K37J@204457|Sphingomonadales 204457|Sphingomonadales E X-Pro dipeptidyl-peptidase (S15 family) - - - - - - - - - - - - PD40,Peptidase_S9 k59_304907_1 1123277.KB893186_gene5438 5.52e-32 126.0 COG2133@1|root,COG2133@2|Bacteria,4NF0B@976|Bacteroidetes,47JS6@768503|Cytophagia 976|Bacteroidetes G Glucose / Sorbosone dehydrogenase - - - - - - - - - - - - CBM_6,GSDH,PKD k59_218240_1 580332.Slit_0768 3.21e-21 89.0 COG0088@1|root,COG0088@2|Bacteria,1MXPF@1224|Proteobacteria,2VHS6@28216|Betaproteobacteria,44V4P@713636|Nitrosomonadales 28216|Betaproteobacteria J Forms part of the polypeptide exit tunnel rplD - - ko:K02926 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L4 k59_218240_2 582744.Msip34_0303 2.49e-35 123.0 COG0089@1|root,COG0089@2|Bacteria,1MZXX@1224|Proteobacteria,2VU1C@28216|Betaproteobacteria,2KMY0@206350|Nitrosomonadales 206350|Nitrosomonadales J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome rplW - - ko:K02892 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L23 k59_218240_3 402626.Rpic_3294 2.99e-23 95.5 COG0090@1|root,COG0090@2|Bacteria,1MVTD@1224|Proteobacteria,2VHSD@28216|Betaproteobacteria,1K0IX@119060|Burkholderiaceae 28216|Betaproteobacteria J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity rplB - - ko:K02886 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L2,Ribosomal_L2_C k59_558879_1 1265313.HRUBRA_01023 2.81e-28 107.0 COG2236@1|root,COG2236@2|Bacteria,1MXS1@1224|Proteobacteria,1RPSD@1236|Gammaproteobacteria 1236|Gammaproteobacteria F phosphoribosyltransferase hpt - - ko:K07101 - - - - ko00000 - - - Pribosyltran k59_1072200_1 402881.Plav_0957 6.36e-63 217.0 COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,2TRUM@28211|Alphaproteobacteria,1JN2F@119043|Rhodobiaceae 28211|Alphaproteobacteria E Domain of unknown function (DUF3458_C) ARM repeats pepN GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0016020,GO:0016787,GO:0019538,GO:0033218,GO:0042277,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0070006,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564 3.4.11.2 ko:K01256 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - DUF3458,DUF3458_C,Peptidase_M1 k59_346871_1 94624.Bpet4936 2.3e-24 94.4 COG0096@1|root,COG0096@2|Bacteria,1RDG3@1224|Proteobacteria,2VRBD@28216|Betaproteobacteria,3T3SI@506|Alcaligenaceae 28216|Betaproteobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit rpsH - - ko:K02994 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S8 k59_346871_2 580332.Slit_0782 9.07e-66 204.0 COG0097@1|root,COG0097@2|Bacteria,1R9YZ@1224|Proteobacteria,2VQ4W@28216|Betaproteobacteria,44VQK@713636|Nitrosomonadales 28216|Betaproteobacteria J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center rplF - - ko:K02933 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L6 k59_729842_1 1121035.AUCH01000004_gene390 1.83e-65 207.0 COG3770@1|root,COG3770@2|Bacteria,1PXYG@1224|Proteobacteria,2VRMN@28216|Betaproteobacteria 28216|Betaproteobacteria M Penicillin-insensitive murein endopeptidase - - - - - - - - - - - - Peptidase_M74 k59_175795_1 1217718.ALOU01000064_gene2018 1.16e-147 461.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,2VHUY@28216|Betaproteobacteria,1K0VQ@119060|Burkholderiaceae 28216|Betaproteobacteria E glutamate synthase gltB - 1.4.1.13,1.4.1.14,1.4.7.1 ko:K00265,ko:K00284 ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 - R00021,R00093,R00114,R00248,R10086 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_1283787_1 1095769.CAHF01000011_gene2451 2.32e-99 310.0 COG1657@1|root,COG1657@2|Bacteria,1MUIP@1224|Proteobacteria,2VPPA@28216|Betaproteobacteria 28216|Betaproteobacteria I Squalene--hopene cyclase shc - 4.2.1.129,5.4.99.17 ko:K06045 ko00909,ko01110,map00909,map01110 - R07322,R07323 RC01850,RC01851 ko00000,ko00001,ko01000 - - - SQHop_cyclase_C,SQHop_cyclase_N k59_1198785_2 310539.Q5G7N4_9CAUD 6.4e-49 160.0 4QGVB@10239|Viruses,4QV8Q@35237|dsDNA viruses no RNA stage,4QSSB@28883|Caudovirales,4QM45@10699|Siphoviridae 10699|Siphoviridae S hydrolase activity - - - - - - - - - - - - - k59_1241439_1 710421.Mycch_1104 1.46e-06 49.3 2BZ0R@1|root,2Z7U0@2|Bacteria,2GU1J@201174|Actinobacteria,234V3@1762|Mycobacteriaceae 201174|Actinobacteria S PFAM Nitrile hydratase alpha scnC - 3.5.5.8,4.2.1.84 ko:K01721,ko:K20762 ko00364,ko00380,ko00627,ko00643,ko01120,map00364,map00380,map00627,map00643,map01120 - R02828,R04020,R05379,R05596,R07780,R07854 RC00483,RC00792,RC01345,RC01432 ko00000,ko00001,ko01000 - - - NHase_alpha k59_1241439_2 1492922.GY26_14445 1.11e-48 167.0 COG1902@1|root,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,1RMII@1236|Gammaproteobacteria,1J5TE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family namA - - - - - - - - - - - Oxidored_FMN k59_985640_1 946483.Cenrod_2528 5.87e-25 103.0 COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,2VHM5@28216|Betaproteobacteria,4AAZS@80864|Comamonadaceae 28216|Betaproteobacteria J Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner lepA - - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C k59_985640_2 640081.Dsui_2458 1.71e-114 335.0 COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,2VJ9D@28216|Betaproteobacteria,2KUHJ@206389|Rhodocyclales 206389|Rhodocyclales U Belongs to the peptidase S26 family lepB - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 k59_431565_1 1123368.AUIS01000004_gene125 2.3e-135 398.0 COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,1S1KY@1236|Gammaproteobacteria,2NCIC@225057|Acidithiobacillales 225057|Acidithiobacillales M Mycolic acid cyclopropane synthetase - - 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - - CMAS k59_218315_1 331869.BAL199_03564 6.97e-89 275.0 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQNK@28211|Alphaproteobacteria,4BR75@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria G COG1593 TRAP-type C4-dicarboxylate transport system, large permease component - - - - - - - - - - - - DctM k59_48670_1 382464.ABSI01000009_gene3980 1.67e-38 145.0 COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria 2|Bacteria C 2Fe-2S iron-sulfur cluster binding domain nqrF GO:0005575,GO:0005622,GO:0005623,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044464,GO:0046858 - ko:K04755,ko:K08952,ko:K08953,ko:K08954 - - - - ko00000,ko00194 - - - DUF4445,Fer2 k59_388513_1 1089552.KI911559_gene1984 3.15e-83 276.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,2JRMJ@204441|Rhodospirillales 28211|Alphaproteobacteria V AcrB/AcrD/AcrF family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_603420_2 1354722.JQLS01000004_gene4234 1.63e-47 161.0 COG1024@1|root,COG1024@2|Bacteria,1MXEN@1224|Proteobacteria,2TTIH@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Enoyl-CoA hydratase - - - - - - - - - - - - ECH_1 k59_773226_1 1126627.BAWE01000005_gene6111 2.36e-95 315.0 COG1572@1|root,COG2931@1|root,COG3210@1|root,COG4070@1|root,COG1572@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4070@2|Bacteria,1MU7T@1224|Proteobacteria 1224|Proteobacteria Q COG2931, RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - Autotransporter,Cadherin-like,Calx-beta,DUF4347,He_PIG k59_1156192_1 1123255.JHYS01000002_gene2651 3.31e-11 72.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria,4AAGH@80864|Comamonadaceae 28216|Betaproteobacteria NT chemotaxis - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal,TarH k59_947316_1 543913.D521_0815 6.04e-58 182.0 COG0599@1|root,COG0599@2|Bacteria,1RJU6@1224|Proteobacteria,2VSYU@28216|Betaproteobacteria 28216|Betaproteobacteria E 4-carboxymuconolactone decarboxylase pcaC - 4.1.1.44 ko:K01607 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 - R03470 RC00938 ko00000,ko00001,ko01000 - - - Abhydrolase_1,CMD k59_93912_1 485913.Krac_12092 1.51e-93 288.0 COG4799@1|root,COG4799@2|Bacteria,2G5IX@200795|Chloroflexi 200795|Chloroflexi I PFAM carboxyl transferase - - 2.1.3.15,6.4.1.3 ko:K01966 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R01859 RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_860936_1 717605.Theco_1404 1.69e-19 94.0 COG1232@1|root,COG1232@2|Bacteria,1TQ6W@1239|Firmicutes,4HAUG@91061|Bacilli,26RYF@186822|Paenibacillaceae 91061|Bacilli H Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX hemY - 1.3.3.15,1.3.3.4 ko:K00231 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03222,R04178 RC00885 ko00000,ko00001,ko00002,ko01000 - - iSB619.SA_RS09325 Amino_oxidase k59_1172129_2 1415756.JQMY01000005_gene97 6.69e-56 185.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TSGZ@28211|Alphaproteobacteria,2PFSQ@252301|Oceanicola 28211|Alphaproteobacteria L Transposase IS116/IS110/IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_1299125_1 45157.CMA052CT 9.17e-10 63.5 COG0019@1|root,KOG0622@2759|Eukaryota 2759|Eukaryota E putrescine biosynthetic process from ornithine - GO:0003674,GO:0003824,GO:0004586,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006576,GO:0006591,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009308,GO:0009309,GO:0009445,GO:0009446,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0033387,GO:0034641,GO:0042401,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.4.1.132,2.4.1.257,4.1.1.17 ko:K01581,ko:K03843 ko00330,ko00480,ko00510,ko00513,ko01100,ko01110,ko01130,map00330,map00480,map00510,map00513,map01100,map01110,map01130 M00055,M00134 R00670,R05973,R06238 RC00299 ko00000,ko00001,ko00002,ko01000,ko01003 - GT4 - Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_404754_1 101510.RHA1_ro04494 1.41e-57 191.0 COG2072@1|root,COG2072@2|Bacteria,2GM3S@201174|Actinobacteria,4FXC2@85025|Nocardiaceae 201174|Actinobacteria P L-lysine 6-monooxygenase (NADPH-requiring) - - - ko:K07222 - - - - ko00000 - - - Pyr_redox_3 k59_366422_1 1150599.MPHLEI_21189 7.07e-76 242.0 COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,233QF@1762|Mycobacteriaceae 201174|Actinobacteria C Aldehyde dehydrogenase - - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_68419_1 1288494.EBAPG3_4260 3.85e-72 233.0 COG0166@1|root,COG0166@2|Bacteria,1MUFP@1224|Proteobacteria,2VHR9@28216|Betaproteobacteria,371Q3@32003|Nitrosomonadales 28216|Betaproteobacteria G Belongs to the GPI family pgi - 5.3.1.9 ko:K01810 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114 R02739,R02740,R03321 RC00376,RC00563 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGI k59_573024_1 1304883.KI912532_gene2652 6.25e-67 211.0 COG1562@1|root,COG1562@2|Bacteria,1N6J2@1224|Proteobacteria,2VIZC@28216|Betaproteobacteria,2KUC0@206389|Rhodocyclales 206389|Rhodocyclales I phytoene - - 2.5.1.32,2.5.1.99 ko:K02291 ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110 M00097 R02065,R04218,R07270,R10177 RC00362,RC01101,RC02869 ko00000,ko00001,ko00002,ko01000,ko01006 - - - SQS_PSY k59_703406_1 1191523.MROS_2810 1.82e-41 146.0 COG2086@1|root,COG2086@2|Bacteria 2|Bacteria C electron transfer activity etfB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0022900,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0055114 - ko:K03521 - - - - ko00000 - - - ETF k59_958979_1 1047013.AQSP01000034_gene1654 2.46e-62 204.0 COG0343@1|root,COG0343@2|Bacteria,2NNQS@2323|unclassified Bacteria 2|Bacteria J Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) tgt GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046116,GO:0046483,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.29 ko:K00773 - - R03789,R10209 RC00063 ko00000,ko01000,ko03016 - - - TGT k59_233879_1 391595.RLO149_c008170 2.46e-82 257.0 COG2358@1|root,COG2358@2|Bacteria,1Q6GH@1224|Proteobacteria,2U1DH@28211|Alphaproteobacteria,2P4C7@2433|Roseobacter 28211|Alphaproteobacteria S NMT1-like family - - - ko:K07080 - - - - ko00000 - - - NMT1_3 k59_233879_2 1408164.MOLA814_01775 2.65e-22 95.1 COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,2WEXA@28216|Betaproteobacteria 28216|Betaproteobacteria P sulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase k59_274781_2 288000.BBta_0389 1.37e-41 143.0 COG2755@1|root,COG2755@2|Bacteria,1RCXZ@1224|Proteobacteria,2U74E@28211|Alphaproteobacteria,3JQRR@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E GDSL-like Lipase/Acylhydrolase tesA - 3.1.1.5 ko:K10804 ko01040,map01040 - - - ko00000,ko00001,ko01000,ko01004 - - - Lipase_GDSL_2 k59_146720_1 864069.MicloDRAFT_00005200 6.65e-44 152.0 COG0175@1|root,COG0175@2|Bacteria,1MUCZ@1224|Proteobacteria,2TT2D@28211|Alphaproteobacteria,1JRIT@119045|Methylobacteriaceae 28211|Alphaproteobacteria H TIGRFAM sulfate adenylyltransferase, small subunit cysD - 2.7.7.4 ko:K00957 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R04929 RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - PAPS_reduct k59_146720_2 317013.NY99_07995 1.53e-14 73.6 COG0529@1|root,COG2895@1|root,COG0529@2|Bacteria,COG2895@2|Bacteria,1MUD9@1224|Proteobacteria,1RME4@1236|Gammaproteobacteria,1X3RS@135614|Xanthomonadales 135614|Xanthomonadales H Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily cysC - 2.7.1.25,2.7.7.4 ko:K00955 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176 R00509,R00529,R04928,R04929 RC00002,RC00078,RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - APS_kinase,GTP_EFTU,GTP_EFTU_D3 k59_1257649_1 1349767.GJA_4068 2.95e-39 150.0 COG1305@1|root,COG1305@2|Bacteria,1MWCE@1224|Proteobacteria,2VHZP@28216|Betaproteobacteria,4726K@75682|Oxalobacteraceae 28216|Betaproteobacteria E Domain of unknown function (DUF3488) - - 2.3.2.13 ko:K22452 - - - - ko00000,ko01000 - - - DUF3488,DUF4129,Transglut_core k59_916591_1 1249627.D779_0453 9.71e-36 139.0 COG3437@1|root,COG3437@2|Bacteria,1R0ZH@1224|Proteobacteria,1S4GZ@1236|Gammaproteobacteria,1X0BF@135613|Chromatiales 135613|Chromatiales KT HD domain - - - - - - - - - - - - HD_5,PAS_4 k59_23397_1 1150469.RSPPHO_00001 2.61e-17 83.2 COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,2TRTY@28211|Alphaproteobacteria,2JQU2@204441|Rhodospirillales 204441|Rhodospirillales T CHASE2 - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CHASE2,Guanylate_cyc k59_23397_2 1122604.JONR01000009_gene2309 5.21e-95 286.0 COG1235@1|root,COG1235@2|Bacteria,1NW4Z@1224|Proteobacteria,1RPS3@1236|Gammaproteobacteria 1236|Gammaproteobacteria S COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I - - - - - - - - - - - - Lactamase_B_2 k59_404868_2 1123072.AUDH01000013_gene1495 4.25e-11 63.9 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2TSYQ@28211|Alphaproteobacteria,2JPTW@204441|Rhodospirillales 204441|Rhodospirillales O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_573106_1 446469.Sked_06080 9.61e-62 206.0 COG4108@1|root,COG4108@2|Bacteria,2GKQA@201174|Actinobacteria 201174|Actinobacteria J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP prfC - - ko:K02837 - - - - ko00000,ko03012 - - - GTP_EFTU,RF3_C k59_233946_1 1205680.CAKO01000002_gene2502 2.03e-52 184.0 COG1042@1|root,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2TR24@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG1042 Acyl-CoA synthetase (NDP forming) - - - - - - - - - - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig k59_1215024_1 864069.MicloDRAFT_00007460 2.13e-06 55.1 COG0457@1|root,COG3629@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TUIF@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Bacterial transcriptional activator domain - - - - - - - - - - - - BTAD k59_323667_1 1207076.ALAT01000147_gene283 9.44e-14 70.1 COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,1RNME@1236|Gammaproteobacteria,1Z01S@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria G COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family suhB - 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P k59_323667_2 1038860.AXAP01000004_gene5038 5.33e-67 219.0 COG0477@1|root,COG2814@2|Bacteria,1MVKJ@1224|Proteobacteria,2TUK5@28211|Alphaproteobacteria,3JQXB@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria EGP Sugar (and other) transporter MA20_39450 - - - - - - - - - - - Sugar_tr k59_959100_1 246197.MXAN_4473 1.3e-110 326.0 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,42M98@68525|delta/epsilon subdivisions,2WMKB@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM Integrase catalytic - - - ko:K07497 - - - - ko00000 - - - HTH_21,HTH_Tnp_1,rve k59_274899_1 78245.Xaut_1572 2.79e-09 62.8 COG0508@1|root,COG0596@1|root,COG0508@2|Bacteria,COG0596@2|Bacteria,1MUGY@1224|Proteobacteria,2TRXM@28211|Alphaproteobacteria,3EY01@335928|Xanthobacteraceae 28211|Alphaproteobacteria C The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) - - 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_703538_1 85643.Tmz1t_0743 3.59e-74 224.0 2DKA3@1|root,30905@2|Bacteria,1RGG6@1224|Proteobacteria 1224|Proteobacteria S SnoaL-like domain - - - - - - - - - - - - SnoaL_2 k59_703538_2 196367.JNFG01000020_gene4674 1.46e-28 110.0 COG0596@1|root,COG0596@2|Bacteria,1RB3Q@1224|Proteobacteria,2WEMP@28216|Betaproteobacteria 28216|Betaproteobacteria S alpha/beta hydrolase fold - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_959106_1 1304883.KI912532_gene1266 2.36e-13 69.7 COG2607@1|root,COG2607@2|Bacteria,1MVMX@1224|Proteobacteria,2VID5@28216|Betaproteobacteria,2KUQI@206389|Rhodocyclales 206389|Rhodocyclales S ATPase (AAA - - - ko:K06923 - - - - ko00000 - - - DUF815 k59_959106_2 887062.HGR_01066 3.45e-66 214.0 COG1364@1|root,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,2VJ84@28216|Betaproteobacteria,4AACJ@80864|Comamonadaceae 28216|Betaproteobacteria E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate argJ - 2.3.1.1,2.3.1.35 ko:K00620 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259,R02282 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - ArgJ k59_1299392_1 502558.EGYY_05290 1.98e-35 137.0 COG0143@1|root,COG0143@2|Bacteria,2GK4S@201174|Actinobacteria,4CUHQ@84998|Coriobacteriia 84998|Coriobacteriia J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG - 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1g k59_1172376_1 204773.HEAR3276 4.43e-56 180.0 COG1595@1|root,COG1595@2|Bacteria,1MZMC@1224|Proteobacteria,2VSEK@28216|Betaproteobacteria,474CT@75682|Oxalobacteraceae 28216|Betaproteobacteria K Sigma-70, region 4 rpoE8 - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_1091911_2 398525.KB900701_gene616 2.91e-36 136.0 COG2072@1|root,COG2072@2|Bacteria,1MWPJ@1224|Proteobacteria,2TT05@28211|Alphaproteobacteria,3JS8N@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P Flavin-binding monooxygenase-like - - - - - - - - - - - - Pyr_redox_3 k59_1347170_1 159087.Daro_3260 2.34e-95 294.0 COG2010@1|root,COG3391@1|root,COG2010@2|Bacteria,COG3391@2|Bacteria,1PYK3@1224|Proteobacteria,2VIU7@28216|Betaproteobacteria,2KU6N@206389|Rhodocyclales 206389|Rhodocyclales C cytochrome nirN - - - - - - - - - - - Cytochrom_D1,Cytochrome_CBB3 k59_1172386_1 224911.27351989 6.39e-79 246.0 COG1294@1|root,COG1294@2|Bacteria,1MURP@1224|Proteobacteria,2TU3I@28211|Alphaproteobacteria,3K2TF@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Cytochrome bd terminal oxidase subunit II cydB - 1.10.3.14 ko:K00426 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_II k59_1049566_1 1297863.APJF01000013_gene3902 5.76e-37 130.0 COG0262@1|root,COG0262@2|Bacteria,1RH0P@1224|Proteobacteria,2U9GC@28211|Alphaproteobacteria,3JQWH@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis folA - 1.5.1.3 ko:K00287 ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523 M00126,M00840 R00936,R00937,R00939,R00940,R02235,R02236,R11765 RC00109,RC00110,RC00158 ko00000,ko00001,ko00002,ko01000 - - - DHFR_1 k59_1049566_2 323261.Noc_0783 1.36e-06 52.8 COG0642@1|root,COG2205@2|Bacteria,1N58A@1224|Proteobacteria,1RP34@1236|Gammaproteobacteria,1WYRG@135613|Chromatiales 135613|Chromatiales T Histidine kinase - - 2.7.13.3 ko:K07711 ko02020,ko02024,map02020,map02024 M00502 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_23553_2 589865.DaAHT2_0078 4.84e-41 143.0 COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,42MEE@68525|delta/epsilon subdivisions,2WJYV@28221|Deltaproteobacteria,2MJ0G@213118|Desulfobacterales 28221|Deltaproteobacteria O Belongs to the peptidase M48B family htpX - - ko:K03799 - M00743 - - ko00000,ko00002,ko01000,ko01002 - - - Peptidase_M48 k59_146896_1 1205680.CAKO01000006_gene3155 2.15e-69 222.0 COG0683@1|root,COG0683@2|Bacteria,1MWR8@1224|Proteobacteria,2UQXU@28211|Alphaproteobacteria,2JYN9@204441|Rhodospirillales 204441|Rhodospirillales E Receptor family ligand binding region - - - - - - - - - - - - Peripla_BP_6 k59_108210_2 572477.Alvin_1456 3.81e-31 119.0 COG1566@1|root,COG1566@2|Bacteria,1RBK7@1224|Proteobacteria,1S241@1236|Gammaproteobacteria,1X2HT@135613|Chromatiales 135613|Chromatiales V HlyD family secretion protein - - - ko:K01993 - - - - ko00000 - - - HlyD_3 k59_920485_1 1123023.JIAI01000009_gene968 3.34e-74 232.0 COG5285@1|root,COG5285@2|Bacteria 2|Bacteria Q dioxygenase activity htxA - 1.14.11.18 ko:K00477 ko04146,map04146 - - - ko00000,ko00001,ko01000 - - - PhyH k59_1096264_1 388399.SSE37_24309 5.68e-20 95.1 COG3490@1|root,COG3490@2|Bacteria,1NNS5@1224|Proteobacteria,2TTEJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein conserved in bacteria - - - ko:K09947 - - - - ko00000 - - - DUF1513 k59_627373_1 365044.Pnap_1858 6.61e-70 225.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2VI6G@28216|Betaproteobacteria,4AB65@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase odhL GO:0003674,GO:0003824,GO:0004148,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006139,GO:0006163,GO:0006164,GO:0006464,GO:0006637,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0018130,GO:0018335,GO:0019362,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0019752,GO:0031974,GO:0031981,GO:0032787,GO:0032991,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0036211,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043436,GO:0043543,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0046390,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0061732,GO:0070013,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0072524,GO:0090407,GO:0106077,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902494,GO:1990204,GO:1990234 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim k59_627373_2 882378.RBRH_03623 1.58e-33 126.0 COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,2VIEM@28216|Betaproteobacteria,1K1V0@119060|Burkholderiaceae 28216|Betaproteobacteria C The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) sucB - 2.3.1.61 ko:K00658 ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R02570,R02571,R08549 RC00004,RC02727,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_920527_1 1380394.JADL01000001_gene2038 1.82e-47 159.0 COG0406@1|root,COG0406@2|Bacteria,1NPC4@1224|Proteobacteria,2U9WD@28211|Alphaproteobacteria,2JSYG@204441|Rhodospirillales 204441|Rhodospirillales G Phosphoglycerate mutase family - - - - - - - - - - - - His_Phos_1 k59_920527_2 331869.BAL199_10622 6.49e-26 106.0 COG4671@1|root,COG4671@2|Bacteria,1NE6T@1224|Proteobacteria,2U08G@28211|Alphaproteobacteria,4BQBK@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Glycosyltransferase family 28 C-terminal domain redA - - - - - - - - - - - Glyco_tran_28_C k59_72392_2 1528098.NOVO_08155 1.16e-46 166.0 COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,2TQJT@28211|Alphaproteobacteria,47EXX@766|Rickettsiales 766|Rickettsiales C Malic enzyme maeB - 1.1.1.40 ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200 M00169,M00172 R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - - Malic_M,PTA_PTB,malic k59_278708_1 1286093.C266_16330 5.25e-73 233.0 COG2071@1|root,COG2071@2|Bacteria,1MV8E@1224|Proteobacteria,2VMMI@28216|Betaproteobacteria,1K422@119060|Burkholderiaceae 28216|Betaproteobacteria S peptidase C26 - - 4.1.3.27 ko:K01658,ko:K07010 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000,ko01002 - - - Peptidase_C26 k59_1218955_1 365046.Rta_20250 1.04e-104 311.0 COG2220@1|root,COG2220@2|Bacteria,1MUY6@1224|Proteobacteria,2VM81@28216|Betaproteobacteria,4AGC0@80864|Comamonadaceae 28216|Betaproteobacteria S Beta-lactamase superfamily domain - - - - - - - - - - - - Lactamase_B_3 k59_27395_2 1502770.JQMG01000001_gene1024 1e-37 140.0 COG2165@1|root,COG2165@2|Bacteria,1RIBU@1224|Proteobacteria,2VUK8@28216|Betaproteobacteria,2KMUC@206350|Nitrosomonadales 206350|Nitrosomonadales NU Prokaryotic N-terminal methylation motif - - - - - - - - - - - - N_methyl k59_27395_3 582744.Msip34_0253 5.92e-31 124.0 COG4191@1|root,COG4191@2|Bacteria,1QZS3@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase-like ATPases - - - - - - - - - - - - HATPase_c k59_370429_1 582744.Msip34_0971 5.09e-47 160.0 COG0670@1|root,COG0670@2|Bacteria,1MU69@1224|Proteobacteria,2VKZV@28216|Betaproteobacteria,2KMJ9@206350|Nitrosomonadales 206350|Nitrosomonadales S Belongs to the BI1 family - - - ko:K19416 - M00742 - - ko00000,ko00002,ko02000 1.A.14.2.1 - - Bax1-I k59_1005445_1 1005048.CFU_1252 2.84e-84 261.0 COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,2VH7Y@28216|Betaproteobacteria,472ZF@75682|Oxalobacteraceae 28216|Betaproteobacteria G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno GO:0000015,GO:0000287,GO:0003674,GO:0003824,GO:0004634,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005856,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043167,GO:0043169,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046872,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902494 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N k59_664649_1 522306.CAP2UW1_0634 8.73e-49 174.0 COG0642@1|root,COG0642@2|Bacteria,1R49A@1224|Proteobacteria,2VKU5@28216|Betaproteobacteria 28216|Betaproteobacteria T Histidine kinase-like ATPases - - - - - - - - - - - - HATPase_c k59_327172_1 391625.PPSIR1_16130 1.89e-88 279.0 COG3039@1|root,COG3039@2|Bacteria,1R70H@1224|Proteobacteria,42Y58@68525|delta/epsilon subdivisions,2WTVD@28221|Deltaproteobacteria 28221|Deltaproteobacteria L Transposase domain (DUF772) - - - ko:K07487 - - - - ko00000 - - - DDE_Tnp_1,DUF772 k59_664680_1 2340.JV46_14060 1.5e-51 176.0 COG0154@1|root,COG0154@2|Bacteria,1MWRI@1224|Proteobacteria,1RS2Z@1236|Gammaproteobacteria,1J92V@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Amidase - - - - - - - - - - - - Amidase k59_664680_2 1120956.JHZK01000001_gene3373 0.000905 41.2 COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria,1JPPV@119043|Rhodobiaceae 28211|Alphaproteobacteria Q Tripartite ATP-independent periplasmic transporter, DctM component - - - - - - - - - - - - DctM k59_796733_1 443906.CMM_2745 0.000434 45.4 COG2085@1|root,COG2085@2|Bacteria,2GJF5@201174|Actinobacteria,4FMM4@85023|Microbacteriaceae 201174|Actinobacteria S NADP oxidoreductase coenzyme F420-dependent - - 1.5.1.40 ko:K06988 - - - - ko00000,ko01000 - - - F420_oxidored k59_796733_2 1458357.BG58_08165 1.82e-06 50.1 COG4923@1|root,COG4923@2|Bacteria,1MY1R@1224|Proteobacteria,2WBKP@28216|Betaproteobacteria,1K688@119060|Burkholderiaceae 28216|Betaproteobacteria S Protein of unknown function (DUF429) - - - - - - - - - - - - DUF429 k59_750068_1 1562701.BBOF01000034_gene1016 2.66e-06 48.1 COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,2VH2K@28216|Betaproteobacteria,1K0W5@119060|Burkholderiaceae 28216|Betaproteobacteria E Methionine aminopeptidase map GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009987,GO:0016787,GO:0019538,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0070006,GO:0070011,GO:0070084,GO:0071704,GO:0140096,GO:1901564 3.4.11.18 ko:K01265 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 k59_750068_2 553385.JEMF01000018_gene869 4.93e-43 160.0 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,1RN5T@1236|Gammaproteobacteria,1XHBY@135619|Oceanospirillales 135619|Oceanospirillales O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD - 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,GlnD_UR_UTase,HD,NTP_transf_2 k59_1351042_1 1502852.FG94_02195 1.36e-25 114.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,472RR@75682|Oxalobacteraceae 28216|Betaproteobacteria T PFAM EAL domain, GGDEF domain - - - - - - - - - - - - CHASE,EAL,GGDEF,PAS_4,PAS_9 k59_874806_1 1101195.Meth11DRAFT_0727 1.38e-132 384.0 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,2VHHW@28216|Betaproteobacteria,2KKFY@206350|Nitrosomonadales 206350|Nitrosomonadales NU PFAM type II secretion system protein E - - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_195830_1 649638.Trad_0898 6.25e-23 102.0 COG0508@1|root,COG0508@2|Bacteria,1WIIU@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus C The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) sucB - 2.3.1.61 ko:K00658 ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R02570,R02571,R08549 RC00004,RC02727,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_1351052_2 1123228.AUIH01000049_gene376 6.63e-49 167.0 COG2227@1|root,COG2227@2|Bacteria,1RM6F@1224|Proteobacteria 1224|Proteobacteria H Methyltransferase domain - - - - - - - - - - - - Methyltransf_23,Methyltransf_25 k59_1303663_1 977880.RALTA_A1111 1.69e-59 203.0 COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,2VHHA@28216|Betaproteobacteria,1K174@119060|Burkholderiaceae 28216|Betaproteobacteria L May be involved in recombinational repair of damaged DNA recN - - ko:K03631 - - - - ko00000,ko03400 - - - SMC_N k59_1176396_1 744979.R2A130_3418 4.57e-57 192.0 COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q TRAP-type mannitol chloroaromatic compound transport system large permease component - - - - - - - - - - - - DctM k59_920712_1 661367.LLO_1816 1.59e-29 120.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,1JCH1@118969|Legionellales 118969|Legionellales I 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain yfcX - 1.1.1.35,4.2.1.17,5.1.2.3 ko:K01782 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_920712_2 159087.Daro_1545 1.24e-41 148.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2VMHS@28216|Betaproteobacteria,2KUQ2@206389|Rhodocyclales 206389|Rhodocyclales I Belongs to the thiolase family fadA - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_195857_1 760117.JN27_18730 0.000127 43.5 COG0625@1|root,COG0625@2|Bacteria,1MXHH@1224|Proteobacteria,2VH95@28216|Betaproteobacteria,472S2@75682|Oxalobacteraceae 28216|Betaproteobacteria O Glutathione S-transferase, C-terminal domain gstA - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_C_3,GST_N,GST_N_3 k59_195857_2 1187851.A33M_3618 7.17e-92 283.0 COG0391@1|root,COG0391@2|Bacteria,1NK78@1224|Proteobacteria,2TUUA@28211|Alphaproteobacteria 28211|Alphaproteobacteria S LPPG Fo 2-phospho-L-lactate transferase cofD - 2.7.8.28 ko:K11212 ko00680,ko01120,map00680,map01120 M00378 R09398 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - UPF0052 k59_195857_3 55529.EKX31445 1.01e-06 54.3 COG0400@1|root,KOG2112@2759|Eukaryota 2759|Eukaryota J acyl-protein thioesterase - - 3.1.1.5 ko:K06128,ko:K06130 ko00564,ko05231,map00564,map05231 - R02746,R02747,R03416,R03417 RC00020,RC00037,RC00041,RC00094 ko00000,ko00001,ko01000 - - - Abhydrolase_2 k59_238423_1 1211114.ALIP01000112_gene1793 2.52e-06 55.1 COG2885@1|root,COG3637@1|root,COG2885@2|Bacteria,COG3637@2|Bacteria,1RKGT@1224|Proteobacteria,1S6ZQ@1236|Gammaproteobacteria,1X563@135614|Xanthomonadales 135614|Xanthomonadales M Belongs to the ompA family mopB - - ko:K03286 - - - - ko00000,ko02000 1.B.6 - - OMP_b-brl,OmpA,TSP_3 k59_494369_2 1089544.KB912942_gene1308 1.75e-06 49.7 COG1595@1|root,COG1595@2|Bacteria 2|Bacteria K DNA-templated transcription, initiation - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4,Sigma70_r4_2 k59_537026_1 1266925.JHVX01000004_gene1296 2.16e-38 144.0 COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,2VJ0G@28216|Betaproteobacteria,371W3@32003|Nitrosomonadales 28216|Betaproteobacteria C dehydrogenase, E1 component sucA - 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_537026_2 323848.Nmul_A0856 9.03e-30 116.0 COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,2VIEM@28216|Betaproteobacteria,372IF@32003|Nitrosomonadales 28216|Betaproteobacteria C The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) sucB - 2.3.1.61 ko:K00658 ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R02570,R02571,R08549 RC00004,RC02727,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_963200_1 998674.ATTE01000001_gene2257 1.44e-86 263.0 COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,1RPHB@1236|Gammaproteobacteria,4605I@72273|Thiotrichales 72273|Thiotrichales M Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxA - 2.3.1.129 ko:K00677 ko00540,ko01100,ko01503,map00540,map01100,map01503 M00060 R04567 RC00039,RC00055 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Acetyltransf_11,Hexapep k59_16614_1 626418.bglu_1g12520 1.43e-105 320.0 COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,2VH93@28216|Betaproteobacteria,1K1ZE@119060|Burkholderiaceae 28216|Betaproteobacteria O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA - - ko:K04485 - - - - ko00000,ko03400 - - - AAA_25,ATPase,ChlI,Lon_C k59_739345_1 650150.ERH_1029 9.39e-21 99.8 COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,1TP3F@1239|Firmicutes,3VP78@526524|Erysipelotrichia 526524|Erysipelotrichia KLT Psort location CytoplasmicMembrane, score prkC - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase k59_1083729_1 1207063.P24_09521 7.31e-61 202.0 COG0477@1|root,COG2814@2|Bacteria,1MX2P@1224|Proteobacteria,2TWIP@28211|Alphaproteobacteria,2JQZZ@204441|Rhodospirillales 204441|Rhodospirillales EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_1083745_1 296591.Bpro_0619 6.15e-79 244.0 COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VPME@28216|Betaproteobacteria,4ADEN@80864|Comamonadaceae 28216|Betaproteobacteria S Tripartite tricarboxylate transporter family receptor - - - - - - - - - - - - TctC k59_526276_1 604331.AUHY01000007_gene693 9.68e-61 206.0 COG0021@1|root,COG0021@2|Bacteria,1WITH@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_696816_1 1547437.LL06_10875 1.93e-93 288.0 COG1593@1|root,COG1593@2|Bacteria,1N1HM@1224|Proteobacteria,2TR8B@28211|Alphaproteobacteria,43HPN@69277|Phyllobacteriaceae 28211|Alphaproteobacteria G Tripartite ATP-independent periplasmic transporter, DctM component - - - - - - - - - - - - DctM k59_1208311_1 82654.Pse7367_1168 1.02e-10 70.1 COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1G107@1117|Cyanobacteria,1H9NE@1150|Oscillatoriales 1117|Cyanobacteria T CHASE2 domain - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CHASE2,Guanylate_cyc k59_1338929_1 204773.HEAR0483 5.79e-17 83.2 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,4733N@75682|Oxalobacteraceae 28216|Betaproteobacteria T Sigma-54 interaction domain aoxR - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_1041388_1 234267.Acid_6861 6.78e-50 161.0 COG2963@1|root,COG2963@2|Bacteria 2|Bacteria L transposase activity - - - ko:K07483,ko:K07497 - - - - ko00000 - - - HTH_Tnp_1 k59_1041388_2 234267.Acid_6069 1.27e-111 329.0 COG2801@1|root,COG2801@2|Bacteria 2|Bacteria L transposition - - - - - - - - - - - - HTH_21,rve,rve_3 k59_60472_1 1298867.AUES01000001_gene1605 6.15e-33 123.0 COG1893@1|root,COG1893@2|Bacteria,1MVZ1@1224|Proteobacteria,2TRJN@28211|Alphaproteobacteria,3JWE8@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria H Ketopantoate reductase PanE/ApbA C terminal - - 1.1.1.169 ko:K00077 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R02472 RC00726 ko00000,ko00001,ko00002,ko01000 - - - ApbA,ApbA_C k59_60472_2 331869.BAL199_27940 5.67e-40 140.0 COG2084@1|root,COG2084@2|Bacteria,1NRG2@1224|Proteobacteria,2VFEF@28211|Alphaproteobacteria 28211|Alphaproteobacteria I NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - 1.1.1.31 ko:K00020 ko00280,ko01100,map00280,map01100 - R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_483617_1 76114.ebA2619 1.21e-137 407.0 COG0155@1|root,COG0155@2|Bacteria,1MVVB@1224|Proteobacteria,2VIYX@28216|Betaproteobacteria,2KU69@206389|Rhodocyclales 206389|Rhodocyclales C Sulfite reductase cysI - 1.8.1.2 ko:K00381 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R00858 RC00065 ko00000,ko00001,ko00002,ko01000 - - - NIR_SIR,NIR_SIR_ferr k59_60479_1 95619.PM1_0229010 5.49e-52 184.0 COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,1RMH1@1236|Gammaproteobacteria 1236|Gammaproteobacteria U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022607,GO:0031224,GO:0031226,GO:0032977,GO:0033036,GO:0034613,GO:0042886,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051205,GO:0051234,GO:0051259,GO:0051260,GO:0051641,GO:0061024,GO:0065003,GO:0070727,GO:0071702,GO:0071705,GO:0071840,GO:0071944,GO:0072657,GO:0090150 - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas k59_526312_1 1528106.JRJE01000004_gene619 2.22e-99 304.0 COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2TRA0@28211|Alphaproteobacteria,2JQ2J@204441|Rhodospirillales 204441|Rhodospirillales I Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) - - 6.4.1.4 ko:K01969 ko00280,ko01100,map00280,map01100 M00036 R04138 RC00367,RC00942 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_358559_1 1217720.ALOX01000053_gene1584 2.48e-46 168.0 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria,2JQY7@204441|Rhodospirillales 204441|Rhodospirillales C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - 1.2.5.3 ko:K03520 - - R11168 RC02800 ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_526338_1 269796.Rru_A1516 4.4e-73 223.0 COG3293@1|root,COG3293@2|Bacteria,1RFRK@1224|Proteobacteria,2U8TH@28211|Alphaproteobacteria,2JTJP@204441|Rhodospirillales 204441|Rhodospirillales L Putative transposase of IS4/5 family (DUF4096) - - - - - - - - - - - - DUF4096 k59_526338_2 269796.Rru_A1515 9.88e-54 171.0 COG3293@1|root,COG3293@2|Bacteria,1PVIT@1224|Proteobacteria,2TURP@28211|Alphaproteobacteria,2JSDJ@204441|Rhodospirillales 204441|Rhodospirillales L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_2,DUF4096 k59_739433_1 69279.BG36_16355 2.25e-68 227.0 COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,2TWBA@28211|Alphaproteobacteria,43MU4@69277|Phyllobacteriaceae 28211|Alphaproteobacteria C Transketolase, pyrimidine binding domain - - 1.2.4.4 ko:K11381,ko:K21416 ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130 M00036 R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00027,RC00627,RC02743,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 - - - Biotin_lipoyl,E1_dh,Transket_pyr,Transketolase_C k59_1121035_1 561175.KB894101_gene4649 1.98e-52 179.0 COG0154@1|root,COG0154@2|Bacteria,2GKPZ@201174|Actinobacteria,4EN0I@85012|Streptosporangiales 201174|Actinobacteria J Amidase - - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_20970_1 1123487.KB892834_gene2786 2.28e-120 352.0 COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,2VIR9@28216|Betaproteobacteria,2KUHG@206389|Rhodocyclales 206389|Rhodocyclales D Rod shape-determining protein MreB mreB - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl k59_363811_1 670292.JH26_21535 4.58e-70 216.0 COG3335@1|root,COG3335@2|Bacteria,1P76X@1224|Proteobacteria,2U16U@28211|Alphaproteobacteria,1JRW2@119045|Methylobacteriaceae 28211|Alphaproteobacteria L DDE superfamily endonuclease - - - - - - - - - - - - DDE_3 k59_363811_2 1089552.KI911559_gene1027 1.4e-18 83.2 COG3415@1|root,COG3415@2|Bacteria,1ND8F@1224|Proteobacteria,2UEU9@28211|Alphaproteobacteria,2JYGT@204441|Rhodospirillales 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - HTH_28,HTH_Tnp_IS630 k59_402441_1 1198452.Jab_2c29780 7.22e-46 154.0 COG2050@1|root,COG2050@2|Bacteria,1RH35@1224|Proteobacteria,2VRC2@28216|Betaproteobacteria,474D2@75682|Oxalobacteraceae 28216|Betaproteobacteria Q phenylacetic acid degradation protein paaI GO:0003674,GO:0003824,GO:0016289,GO:0016787,GO:0016788,GO:0016790 - ko:K02614 ko00360,map00360 - R09840 RC00004,RC00014 ko00000,ko00001,ko01000 - - - 4HBT k59_402441_2 626418.bglu_1g04460 3.62e-147 426.0 COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,2VI46@28216|Betaproteobacteria,1K11N@119060|Burkholderiaceae 28216|Betaproteobacteria H Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) paaK - 6.2.1.30 ko:K01912 ko00360,ko01120,ko05111,map00360,map01120,map05111 - R02539 RC00004,RC00014 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C_2 k59_914215_1 340.xcc-b100_3951 2.26e-63 209.0 COG1252@1|root,COG1252@2|Bacteria,1MX96@1224|Proteobacteria,1RM9I@1236|Gammaproteobacteria,1X3HK@135614|Xanthomonadales 135614|Xanthomonadales C NADH dehydrogenase, FAD-containing subunit ndh - 1.6.99.3 ko:K03885 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_487893_2 768671.ThimaDRAFT_2665 4.08e-49 174.0 COG5473@1|root,COG5473@2|Bacteria,1R8RR@1224|Proteobacteria,1S0TC@1236|Gammaproteobacteria,1WWZI@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_487893_3 338969.Rfer_1756 2.07e-27 117.0 COG0477@1|root,COG2814@2|Bacteria,1QUY6@1224|Proteobacteria,2VNN5@28216|Betaproteobacteria,4AAMP@80864|Comamonadaceae 28216|Betaproteobacteria EGP Major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_363882_1 596154.Alide2_2310 5.72e-61 202.0 COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,2VHN4@28216|Betaproteobacteria,4ABUH@80864|Comamonadaceae 28216|Betaproteobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family cysS - 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,tRNA-synt_1e,tRNA-synt_1g k59_487944_1 266265.Bxe_C1226 1.03e-14 77.4 COG2079@1|root,COG2079@2|Bacteria,1NECN@1224|Proteobacteria,2VN65@28216|Betaproteobacteria,1K3BE@119060|Burkholderiaceae 28216|Betaproteobacteria S MmgE/PrpD family - - - - - - - - - - - - MmgE_PrpD k59_1046672_1 395494.Galf_1005 5.7e-38 144.0 COG1639@1|root,COG2199@1|root,COG1639@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2VHDQ@28216|Betaproteobacteria,44VWQ@713636|Nitrosomonadales 28216|Betaproteobacteria T SMART GGDEF domain containing protein - - - - - - - - - - - - GGDEF,HDOD,Response_reg k59_321597_1 1121035.AUCH01000014_gene2377 2.68e-88 287.0 COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,2VKKZ@28216|Betaproteobacteria,2KV93@206389|Rhodocyclales 206389|Rhodocyclales E Putative amidoligase enzyme (DUF2126) - - - - - - - - - - - - Bact_transglu_N,DUF2126,Transglut_core k59_999251_1 391038.Bphy_2803 3.69e-34 124.0 COG2717@1|root,COG2717@2|Bacteria,1RDUP@1224|Proteobacteria,2VRBQ@28216|Betaproteobacteria,1K3TE@119060|Burkholderiaceae 28216|Betaproteobacteria C Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain msrQ - - ko:K17247 - - - - ko00000 - - - Ferric_reduct k59_999251_2 640081.Dsui_1300 6.56e-10 58.5 COG2041@1|root,COG2041@2|Bacteria,1MUW0@1224|Proteobacteria,2VH08@28216|Betaproteobacteria,2KV6B@206389|Rhodocyclales 206389|Rhodocyclales C Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide msrP - - ko:K07147 - - - - ko00000,ko01000 - - - Oxidored_molyb k59_1212691_1 1095769.CAHF01000022_gene341 2.73e-56 198.0 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,2VJEX@28216|Betaproteobacteria,476HV@75682|Oxalobacteraceae 28216|Betaproteobacteria NU Neisseria PilC beta-propeller domain pilY1 - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC k59_272724_1 1320556.AVBP01000007_gene569 1.84e-111 340.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria,43N97@69277|Phyllobacteriaceae 28211|Alphaproteobacteria IQ AMP-binding enzyme C-terminal domain fadD GO:0001676,GO:0003674,GO:0003824,GO:0004467,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006635,GO:0006637,GO:0006644,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009056,GO:0009058,GO:0009062,GO:0009117,GO:0009150,GO:0009259,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009898,GO:0009987,GO:0015645,GO:0016020,GO:0016042,GO:0016054,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0019395,GO:0019637,GO:0019693,GO:0019752,GO:0030258,GO:0031406,GO:0032787,GO:0033293,GO:0033865,GO:0033875,GO:0034032,GO:0034440,GO:0034641,GO:0035383,GO:0036041,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046395,GO:0046483,GO:0050896,GO:0051186,GO:0055086,GO:0055114,GO:0070538,GO:0071704,GO:0071944,GO:0072329,GO:0072521,GO:0090407,GO:0098552,GO:0098562,GO:1901135,GO:1901360,GO:1901564,GO:1901575,GO:1901576 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_189525_1 543632.JOJL01000002_gene8246 2.28e-111 350.0 COG0146@1|root,COG0146@2|Bacteria,2HWA8@201174|Actinobacteria,4DITC@85008|Micromonosporales 201174|Actinobacteria EQ Hydantoinase B/oxoprolinase - - 3.5.2.14 ko:K01474 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Acetone_carb_G,Hydantoinase_B k59_1255397_1 946483.Cenrod_0414 5.14e-87 272.0 COG0493@1|root,COG1144@1|root,COG0493@2|Bacteria,COG1144@2|Bacteria,1MU2H@1224|Proteobacteria,2VM9R@28216|Betaproteobacteria,4AD4V@80864|Comamonadaceae 28216|Betaproteobacteria C Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - - - - - - - - - - Fer4,Fer4_20,Pyr_redox_2,Pyr_redox_3 k59_65920_1 1123487.KB892836_gene3182 2.4e-129 395.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2VH3Q@28216|Betaproteobacteria,2KUCG@206389|Rhodocyclales 206389|Rhodocyclales F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen nrdA - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_lgC k59_701194_1 1207063.P24_03740 2.18e-24 98.2 COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,2TTVR@28211|Alphaproteobacteria,2JPS1@204441|Rhodospirillales 204441|Rhodospirillales O Belongs to the GST superfamily - - - ko:K11209 - - - - ko00000,ko01000 - - - GST_C,GST_N k59_701194_2 1100720.ALKN01000045_gene433 3.55e-103 306.0 COG4221@1|root,COG4221@2|Bacteria,1MWXS@1224|Proteobacteria,2VHSZ@28216|Betaproteobacteria 28216|Betaproteobacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_1297030_1 113395.AXAI01000002_gene5223 2.51e-28 114.0 COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S ABC transporter substrate binding protein - - - ko:K01989 - M00247 - - ko00000,ko00002,ko02000 - - - ABC_sub_bind k59_1089198_1 640081.Dsui_3334 4.44e-06 48.1 COG3437@1|root,COG5001@1|root,COG3437@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KVEE@206389|Rhodocyclales 206389|Rhodocyclales T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS_3,Response_reg k59_1089198_2 987059.RBXJA2T_14566 1.11e-24 107.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2VHAN@28216|Betaproteobacteria,1KJ7I@119065|unclassified Burkholderiales 28216|Betaproteobacteria V ABC transporter, transmembrane region - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_530741_1 1121861.KB899931_gene159 8.74e-29 114.0 COG1073@1|root,COG2114@1|root,COG2197@1|root,COG1073@2|Bacteria,COG2114@2|Bacteria,COG2197@2|Bacteria,1QWKB@1224|Proteobacteria,2TX0H@28211|Alphaproteobacteria 28211|Alphaproteobacteria KT Serine aminopeptidase, S33 - - - - - - - - - - - - Abhydrolase_1,GerE,Guanylate_cyc,Hydrolase_4 k59_790283_1 63737.Npun_F0305 2.29e-09 63.9 COG2931@1|root,COG2931@2|Bacteria,1GQCK@1117|Cyanobacteria 1117|Cyanobacteria Q PFAM Hemolysin-type calcium-binding - - 3.4.24.40 ko:K01406 ko01503,map01503 - - - ko00000,ko00001,ko01000,ko01002 - - - Calx-beta,DUF4347,HemolysinCabind,VCBS k59_658001_1 1380355.JNIJ01000030_gene5629 4.05e-46 165.0 COG2801@1|root,COG2801@2|Bacteria,1MWVQ@1224|Proteobacteria,2TQPC@28211|Alphaproteobacteria,3JZ69@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L Homeodomain-like domain - - - ko:K18996 - - - - ko00000,ko03032 - - - HTH_28,HTH_29,HTH_32,rve k59_364071_1 1163617.SCD_n01612 1.16e-138 407.0 COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,2VHVA@28216|Betaproteobacteria 28216|Betaproteobacteria F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG GO:0001775,GO:0002376,GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008283,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032943,GO:0034404,GO:0034641,GO:0034654,GO:0042098,GO:0042100,GO:0042110,GO:0042113,GO:0042221,GO:0042455,GO:0042493,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045321,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046649,GO:0046651,GO:0050896,GO:0055086,GO:0070661,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - - CTP_synth_N,GATase k59_1212797_2 1122604.JONR01000023_gene4156 1.57e-139 399.0 COG0842@1|root,COG0842@2|Bacteria,1MUH1@1224|Proteobacteria,1RP0Z@1236|Gammaproteobacteria,1X3BP@135614|Xanthomonadales 135614|Xanthomonadales V Transport permease protein yadH - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane k59_189645_1 1424334.W822_18525 1.9e-43 152.0 COG1414@1|root,COG1414@2|Bacteria,1PXJ1@1224|Proteobacteria,2WCYI@28216|Betaproteobacteria,3T6HC@506|Alcaligenaceae 28216|Betaproteobacteria K Bacterial transcriptional regulator - - - - - - - - - - - - HTH_IclR,IclR k59_869234_1 1380394.JADL01000016_gene398 6.37e-74 231.0 COG0235@1|root,COG0235@2|Bacteria,1MWP9@1224|Proteobacteria,2TRMV@28211|Alphaproteobacteria,2JRJV@204441|Rhodospirillales 204441|Rhodospirillales G COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases - - - - - - - - - - - - Aldolase_II k59_1297104_1 1123366.TH3_03419 1.29e-30 118.0 28HAG@1|root,2Z7MV@2|Bacteria,1PMGH@1224|Proteobacteria,2U27X@28211|Alphaproteobacteria,2JPS8@204441|Rhodospirillales 204441|Rhodospirillales - - - - - - - - - - - - - - - k59_402685_1 1288494.EBAPG3_28130 1.06e-100 303.0 COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,2VGZP@28216|Betaproteobacteria,372QQ@32003|Nitrosomonadales 28216|Betaproteobacteria D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring ftsA - - ko:K03590 ko04112,map04112 - - - ko00000,ko00001,ko03036,ko04812 - - - FtsA,SHS2_FTSA k59_272856_1 977880.RALTA_A2582 4.3e-95 289.0 COG0382@1|root,COG0382@2|Bacteria,1MV4Q@1224|Proteobacteria,2VHEU@28216|Betaproteobacteria,1K3QR@119060|Burkholderiaceae 28216|Betaproteobacteria H Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate ubiA - 2.5.1.39 ko:K03179 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R05000,R05615 RC00209,RC02895 ko00000,ko00001,ko00002,ko01000,ko01006 - - - UbiA k59_1255565_1 1248916.ANFY01000017_gene1406 1.22e-19 90.9 COG0464@1|root,COG0464@2|Bacteria,1MXFG@1224|Proteobacteria,2TTA9@28211|Alphaproteobacteria 28211|Alphaproteobacteria O ATPase with chaperone activity - - - - - - - - - - - - - k59_488166_1 883077.HMPREF9241_00764 9.14e-20 97.1 COG0553@1|root,COG0553@2|Bacteria,2GISC@201174|Actinobacteria,4D3XH@85005|Actinomycetales 201174|Actinobacteria KL SNF2 family N-terminal domain protein helZ - - - - - - - - - - - Helicase_C,SNF2_N,SNF2_assoc,SWIM k59_869318_1 391937.NA2_18220 1.83e-22 101.0 COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,2USBQ@28211|Alphaproteobacteria,43IWP@69277|Phyllobacteriaceae 28211|Alphaproteobacteria V Type I secretion system ATPase - - - ko:K12541 ko02010,map02010 M00330 - - ko00000,ko00001,ko00002,ko02000,ko02044 3.A.1.109.3,3.A.1.109.4 - - ABC_membrane,ABC_tran,Peptidase_C39 k59_1089365_1 1519464.HY22_04845 1.41e-13 75.9 COG3852@1|root,COG3852@2|Bacteria 1519464.HY22_04845|- T phosphorelay sensor kinase activity - - - - - - - - - - - - - k59_231854_1 381666.H16_A0114 1.37e-62 203.0 COG1792@1|root,COG1792@2|Bacteria,1N8ZS@1224|Proteobacteria,2VK0Y@28216|Betaproteobacteria,1K372@119060|Burkholderiaceae 28216|Betaproteobacteria M shape-determining protein MreC mreC - - ko:K03570 - - - - ko00000,ko03036 9.B.157.1 - - MreC k59_66211_1 717785.HYPMC_1710 7.41e-31 120.0 COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2TSA7@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - DDE_Tnp_1_6,DUF772 k59_231883_1 1354722.JQLS01000005_gene3881 4.18e-95 283.0 COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,2TRGY@28211|Alphaproteobacteria,46S2R@74030|Roseovarius 28211|Alphaproteobacteria L IstB-like ATP binding protein - - - - - - - - - - - - IstB_IS21 k59_231885_2 292.DM42_229 2.84e-61 196.0 COG0596@1|root,COG0596@2|Bacteria,1MVVX@1224|Proteobacteria,2VH81@28216|Betaproteobacteria,1K0W4@119060|Burkholderiaceae 28216|Betaproteobacteria S Alpha beta hydrolase phaY2 - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_957036_1 765912.Thimo_1466 6.45e-24 95.5 COG0792@1|root,COG0792@2|Bacteria,1N6VN@1224|Proteobacteria,1SC8A@1236|Gammaproteobacteria,1WYJE@135613|Chromatiales 135613|Chromatiales L Belongs to the UPF0102 family - - - ko:K07460 - - - - ko00000 - - - UPF0102 k59_957036_2 243276.TPANIC_0975 3.03e-13 68.2 COG0313@1|root,COG0313@2|Bacteria,2J5DW@203691|Spirochaetes 203691|Spirochaetes H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA rsmI - 2.1.1.198 ko:K07056 - - - - ko00000,ko01000,ko03009 - - - TP_methylase k59_1089442_1 1396141.BATP01000003_gene4967 7.24e-57 204.0 COG3391@1|root,COG3391@2|Bacteria,46X7X@74201|Verrucomicrobia,2IUXV@203494|Verrucomicrobiae 203494|Verrucomicrobiae C cytochrome C peroxidase - - - - - - - - - - - - CCP_MauG k59_744024_1 1231391.AMZF01000037_gene581 1.65e-59 193.0 COG1028@1|root,COG1028@2|Bacteria,1MWB6@1224|Proteobacteria,2W1GT@28216|Betaproteobacteria,3T5D6@506|Alcaligenaceae 28216|Betaproteobacteria IQ NAD dependent epimerase/dehydratase family - - - - - - - - - - - - adh_short_C2 k59_744024_2 1038860.AXAP01000017_gene2908 2.95e-59 192.0 COG0329@1|root,COG0329@2|Bacteria,1MWAH@1224|Proteobacteria,2TSXX@28211|Alphaproteobacteria,3JX92@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria EM Dihydrodipicolinate synthetase family dapAch4 - 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - DHDPS k59_826506_1 76114.ebA3608 6.06e-64 211.0 COG0591@1|root,COG0591@2|Bacteria,1MUBI@1224|Proteobacteria,2VHA8@28216|Betaproteobacteria,2KUVM@206389|Rhodocyclales 206389|Rhodocyclales E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - - - - - - - - - - SSF k59_364327_1 404589.Anae109_2870 3.27e-19 90.1 2DTFW@1|root,33K6G@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Methyltransf_11,Methyltransf_23 k59_914625_1 1218075.BAYA01000024_gene5318 4.34e-52 176.0 COG1230@1|root,COG1230@2|Bacteria,1MVQB@1224|Proteobacteria,2VMHH@28216|Betaproteobacteria,1K45E@119060|Burkholderiaceae 28216|Betaproteobacteria P TIGRFAM cation diffusion facilitator family transporter - - - ko:K16264 - - - - ko00000,ko02000 2.A.4.1 - - Cation_efflux k59_790582_1 640081.Dsui_3083 2.19e-75 240.0 COG0683@1|root,COG0683@2|Bacteria,1MWR8@1224|Proteobacteria,2VHH6@28216|Betaproteobacteria,2KVK6@206389|Rhodocyclales 206389|Rhodocyclales E amino acid - - - - - - - - - - - - Peripla_BP_6 k59_402881_1 1408419.JHYG01000001_gene1915 9.11e-70 226.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TRI3@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Belongs to the aldehyde dehydrogenase family - - 1.2.1.28 ko:K00141 ko00622,ko00623,ko00627,ko01100,ko01120,ko01220,map00622,map00623,map00627,map01100,map01120,map01220 M00537,M00538 R01293,R01419,R05289,R05663,R05664,R07667 RC00075 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_701500_1 1031711.RSPO_c02093 1.23e-114 358.0 COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,2VJ0G@28216|Betaproteobacteria,1K532@119060|Burkholderiaceae 28216|Betaproteobacteria C Dehydrogenase E1 component sucA - 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_826545_1 331869.BAL199_13021 3.23e-64 211.0 COG0633@1|root,COG2114@1|root,COG0633@2|Bacteria,COG2114@2|Bacteria,1N5XC@1224|Proteobacteria,2TRGX@28211|Alphaproteobacteria,4BQ19@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria CT Adenylyl- / guanylyl cyclase, catalytic domain cyaA - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - Fer2,Guanylate_cyc k59_914660_1 1057002.KB905371_gene17 3.11e-17 75.9 COG0251@1|root,COG0251@2|Bacteria 2|Bacteria J oxidation-reduction process - - - - - - - - - - - - Ribonuc_L-PSP k59_914660_2 1108045.GORHZ_247_00380 4.69e-30 117.0 COG2197@1|root,COG2267@1|root,COG2197@2|Bacteria,COG2267@2|Bacteria,2GN4Z@201174|Actinobacteria,4GGNX@85026|Gordoniaceae 201174|Actinobacteria K helix_turn_helix, Lux Regulon - - - - - - - - - - - - Abhydrolase_1,GerE k59_402915_1 666685.R2APBS1_3946 4.75e-15 77.8 COG1577@1|root,COG1577@2|Bacteria,1N400@1224|Proteobacteria,1SC29@1236|Gammaproteobacteria,1XAB2@135614|Xanthomonadales 135614|Xanthomonadales I GHMP kinases N terminal domain - - 2.7.4.2 ko:K00938 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00095 R03245 RC00002 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_N k59_826566_1 1354722.JQLS01000004_gene4233 1.35e-62 207.0 COG1884@1|root,COG1884@2|Bacteria,1MUXX@1224|Proteobacteria,2U39P@28211|Alphaproteobacteria 28211|Alphaproteobacteria I TIGRFAM methylmalonyl-CoA mutase, large subunit - - 5.4.99.2 ko:K01848 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - MM_CoA_mutase k59_869466_1 1082933.MEA186_30901 1.29e-12 73.9 COG1572@1|root,COG2931@1|root,COG3210@1|root,COG4070@1|root,COG1572@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4070@2|Bacteria,1MU7T@1224|Proteobacteria 1224|Proteobacteria Q COG2931, RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - Autotransporter,Cadherin-like,Calx-beta,DUF4347,He_PIG k59_1125008_1 1123355.JHYO01000005_gene912 1.36e-62 200.0 COG2928@1|root,COG2928@2|Bacteria,1MWT5@1224|Proteobacteria,2TZPK@28211|Alphaproteobacteria,36YDT@31993|Methylocystaceae 28211|Alphaproteobacteria S Protein of unknown function (DUF502) MA20_12960 - - - - - - - - - - - DUF502 k59_1209550_1 543913.D521_1531 3.01e-46 164.0 COG0477@1|root,COG2814@2|Bacteria,1MV79@1224|Proteobacteria,2WHGI@28216|Betaproteobacteria 28216|Betaproteobacteria EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_360066_1 1266925.JHVX01000005_gene1832 1.64e-76 249.0 COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,2VHPK@28216|Betaproteobacteria,371PH@32003|Nitrosomonadales 28216|Betaproteobacteria M Soluble lytic murein transglycosylase L domain slt - - ko:K08309 - - - - ko00000,ko01000,ko01011 - GH23 - SLT,SLT_L k59_786376_1 640081.Dsui_1587 9.41e-113 360.0 COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,2VIJ7@28216|Betaproteobacteria,2KVBE@206389|Rhodocyclales 206389|Rhodocyclales M Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane lptD - - ko:K04744 - - - - ko00000,ko02000 1.B.42.1 - - OstA,OstA_C k59_786381_1 1260251.SPISAL_00210 3.33e-101 307.0 COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,1RNPT@1236|Gammaproteobacteria,1WW8D@135613|Chromatiales 135613|Chromatiales C The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) - - 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_786381_2 999541.bgla_1g28040 6.43e-37 137.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2VI6G@28216|Betaproteobacteria,1K1V8@119060|Burkholderiaceae 28216|Betaproteobacteria C Dehydrogenase lpdA - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim k59_957941_1 1121272.KB903249_gene2462 5.34e-15 76.3 COG0558@1|root,COG0558@2|Bacteria,2GYKW@201174|Actinobacteria,4DCRP@85008|Micromonosporales 201174|Actinobacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pgsA1 GO:0003674,GO:0003824,GO:0003881,GO:0003882,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0030312,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576 2.7.8.11,2.7.8.5 ko:K00995,ko:K00999 ko00562,ko00564,ko01100,ko04070,map00562,map00564,map01100,map04070 - R01801,R01802 RC00002,RC00017,RC00078,RC02795 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf k59_1000439_1 1123060.JONP01000005_gene5592 1.27e-68 218.0 COG0604@1|root,COG0604@2|Bacteria,1MU4N@1224|Proteobacteria,2TRDI@28211|Alphaproteobacteria,2JQ0K@204441|Rhodospirillales 204441|Rhodospirillales C Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N_2 k59_744952_1 1085623.GNIT_1126 6.49e-42 149.0 COG0564@1|root,COG0564@2|Bacteria,1MUBN@1224|Proteobacteria,1RN7F@1236|Gammaproteobacteria,4643F@72275|Alteromonadaceae 1236|Gammaproteobacteria J Responsible for synthesis of pseudouridine from uracil rluD GO:0000027,GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022607,GO:0022613,GO:0022618,GO:0031118,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360 5.4.99.23 ko:K06180 - - - - ko00000,ko01000,ko03009 - - iE2348C_1286.E2348C_2868,iECED1_1282.ECED1_3035,iECSF_1327.ECSF_2432 PseudoU_synth_2,S4 k59_744952_2 1123257.AUFV01000006_gene409 8.79e-05 45.1 COG1496@1|root,COG1496@2|Bacteria,1MW2H@1224|Proteobacteria,1RNV4@1236|Gammaproteobacteria,1X34B@135614|Xanthomonadales 135614|Xanthomonadales S Belongs to the multicopper oxidase YfiH RL5 family - - - ko:K05810 - - - - ko00000,ko01000 - - - Cu-oxidase_4 k59_1171197_1 1469245.JFBG01000023_gene1270 1.53e-120 366.0 COG0398@1|root,COG1249@1|root,COG0398@2|Bacteria,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RQTU@1236|Gammaproteobacteria,1X2Q6@135613|Chromatiales 135613|Chromatiales C SNARE associated Golgi protein - - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim,SNARE_assoc k59_232840_1 751944.HALDL1_11220 1.22e-46 168.0 COG2133@1|root,arCOG02796@2157|Archaea,2XT1Q@28890|Euryarchaeota,23SKI@183963|Halobacteria 183963|Halobacteria G COG2133 Glucose sorbosone dehydrogenases - - - - - - - - - - - - GSDH k59_744999_1 264198.Reut_B3891 1.13e-110 335.0 COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2VK54@28216|Betaproteobacteria 28216|Betaproteobacteria I PFAM carboxyl transferase - - - - - - - - - - - - Carboxyl_trans k59_745025_1 290397.Adeh_1417 4.3e-79 254.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42PMK@68525|delta/epsilon subdivisions,2X5G7@28221|Deltaproteobacteria,2Z35F@29|Myxococcales 28221|Deltaproteobacteria C Acyl-CoA dehydrogenase, N-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1171268_1 323848.Nmul_A0220 6.33e-78 249.0 COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,2VH9N@28216|Betaproteobacteria,371S3@32003|Nitrosomonadales 28216|Betaproteobacteria G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) ptsI - 2.7.3.9 ko:K08483 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 8.A.7 - - PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C k59_489251_1 1123278.KB893511_gene1455 2.01e-20 95.5 COG4993@1|root,COG4993@2|Bacteria,4NFK0@976|Bacteroidetes,47N4C@768503|Cytophagia 976|Bacteroidetes C PQQ-like domain - - 1.1.5.2 ko:K00117 ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130 - R06620 RC00066 ko00000,ko00001,ko01000 - - - Cytochrome_CBB3,PQQ,PQQ_2 k59_67543_1 926569.ANT_12290 1.24e-78 245.0 COG3464@1|root,COG3464@2|Bacteria,2G9B1@200795|Chloroflexi 200795|Chloroflexi L Transposase IS66 family - - - - - - - - - - - - DDE_Tnp_IS66 k59_1256737_1 240292.Ava_1611 1.75e-67 231.0 COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria,1HKNU@1161|Nostocales 1117|Cyanobacteria Q TIGRFAM amino acid adenylation domain - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding k59_1000580_1 1411123.JQNH01000001_gene886 1.64e-72 238.0 COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2TQP0@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Belongs to the ABC transporter superfamily - - - ko:K02031,ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_791829_1 502025.Hoch_5393 4.53e-87 265.0 COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,42M9C@68525|delta/epsilon subdivisions,2WJ75@28221|Deltaproteobacteria,2YV0S@29|Myxococcales 28221|Deltaproteobacteria E ABC transporter - - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran k59_403910_1 1304872.JAGC01000003_gene2689 8.88e-16 75.9 COG4446@1|root,COG4446@2|Bacteria,1N7IZ@1224|Proteobacteria,42V21@68525|delta/epsilon subdivisions,2WRFF@28221|Deltaproteobacteria,2MCVG@213115|Desulfovibrionales 28221|Deltaproteobacteria S Protein of unknown function (DUF1499) - - - - - - - - - - - - DUF1499 k59_403910_2 497321.C664_10657 8.12e-12 65.1 COG3568@1|root,COG3568@2|Bacteria,1R99W@1224|Proteobacteria,2VPVB@28216|Betaproteobacteria,2KUNI@206389|Rhodocyclales 206389|Rhodocyclales L Endonuclease Exonuclease phosphatase - - - - - - - - - - - - Exo_endo_phos k59_1048307_1 859657.RPSI07_2809 7.09e-31 124.0 COG0477@1|root,COG0477@2|Bacteria,1MU46@1224|Proteobacteria,2VHKK@28216|Betaproteobacteria,1K1H6@119060|Burkholderiaceae 28216|Betaproteobacteria EGP Major Facilitator proP_2 - - - - - - - - - - - Sugar_tr k59_1000591_1 1123393.KB891329_gene931 1.5e-65 203.0 COG0691@1|root,COG0691@2|Bacteria,1RDFP@1224|Proteobacteria,2VRG9@28216|Betaproteobacteria,1KRM7@119069|Hydrogenophilales 119069|Hydrogenophilales O SmpB protein - - - ko:K03664 - - - - ko00000 - - - SmpB k59_1000591_2 1198452.Jab_2c11440 4.3e-36 128.0 COG2867@1|root,COG2867@2|Bacteria,1RGUH@1224|Proteobacteria,2VR4X@28216|Betaproteobacteria,47453@75682|Oxalobacteraceae 28216|Betaproteobacteria I Oligoketide cyclase lipid transport protein ratA - - - - - - - - - - - Polyketide_cyc k59_1298290_1 882082.SaccyDRAFT_1680 1.46e-53 182.0 COG3135@1|root,COG3135@2|Bacteria,2GNQX@201174|Actinobacteria,4DYUB@85010|Pseudonocardiales 201174|Actinobacteria Q Benzoate membrane transport protein benE - - ko:K05782 - - - - ko00000,ko02000 2.A.46.1 - - BenE k59_1256765_2 1205680.CAKO01000005_gene3550 2.48e-131 381.0 COG2175@1|root,COG2175@2|Bacteria,1MVI6@1224|Proteobacteria,2TVHF@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q PFAM Taurine catabolism dioxygenase TauD, TfdA family - - - - - - - - - - - - TauD k59_621825_1 1266925.JHVX01000009_gene45 1.01e-108 323.0 COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,2VHX4@28216|Betaproteobacteria,372MJ@32003|Nitrosomonadales 28216|Betaproteobacteria H Belongs to the FPP GGPP synthase family ispB - 2.5.1.90 ko:K02523 ko00900,ko01110,map00900,map01110 - R09248 RC00279 ko00000,ko00001,ko01000,ko01006 - - - polyprenyl_synt k59_489361_2 1216966.BAUC01000026_gene1346 1.19e-16 76.3 COG0590@1|root,COG0590@2|Bacteria,1RGU0@1224|Proteobacteria,1S60Z@1236|Gammaproteobacteria 1236|Gammaproteobacteria FJ Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) tadA GO:0002097,GO:0002100,GO:0003674,GO:0003824,GO:0004000,GO:0005488,GO:0006139,GO:0006382,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008251,GO:0008270,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016553,GO:0016787,GO:0016810,GO:0016814,GO:0019239,GO:0034470,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0046914,GO:0052717,GO:0071704,GO:0090304,GO:1901360 3.5.4.33 ko:K11991 - - R10223 RC00477 ko00000,ko01000,ko03016 - - - MafB19-deam,dCMP_cyt_deam_1 k59_273967_1 1163617.SCD_n00632 1.33e-75 228.0 COG0197@1|root,COG0197@2|Bacteria,1RA0Z@1224|Proteobacteria,2VQ0A@28216|Betaproteobacteria 28216|Betaproteobacteria J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs rplP - - ko:K02878 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L16 k59_273967_2 1502852.FG94_01430 4.39e-10 55.5 COG0255@1|root,COG0255@2|Bacteria,1N6PR@1224|Proteobacteria,2VVNT@28216|Betaproteobacteria,4752D@75682|Oxalobacteraceae 28216|Betaproteobacteria J Belongs to the universal ribosomal protein uL29 family rpmC - - ko:K02904 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L29 k59_1090761_1 375286.mma_2179 2.4e-20 94.4 COG1295@1|root,COG1295@2|Bacteria,1QICW@1224|Proteobacteria,2VJNM@28216|Betaproteobacteria,472DM@75682|Oxalobacteraceae 28216|Betaproteobacteria S Virulence factor BrkB rbn - - ko:K07058 - - - - ko00000 - - - Virul_fac_BrkB k59_365707_2 1454004.AW11_01012 2.09e-48 162.0 COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,2VKF3@28216|Betaproteobacteria 28216|Betaproteobacteria K Transcriptional regulator crp fnr family crp - - ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - Crp,HTH_Crp_2,cNMP_binding k59_1000675_1 1454004.AW11_02554 1.54e-79 245.0 COG0400@1|root,COG0400@2|Bacteria,1RA02@1224|Proteobacteria,2VJ6G@28216|Betaproteobacteria,1KQ05@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria S General function prediction only estB - - ko:K06999 - - - - ko00000 - - - Abhydrolase_2 k59_1048423_2 1336208.JADY01000012_gene2977 3.88e-70 221.0 COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TRH6@28211|Alphaproteobacteria,2JPTF@204441|Rhodospirillales 204441|Rhodospirillales EP Binding-protein-dependent transport system inner membrane component - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_365719_1 1038859.AXAU01000015_gene940 2.1e-61 200.0 COG0457@1|root,COG0457@2|Bacteria,1N01S@1224|Proteobacteria,2TSR4@28211|Alphaproteobacteria,3K3I1@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S COG0457 FOG TPR repeat - - - - - - - - - - - - - k59_1214164_2 1380355.JNIJ01000040_gene5195 7.02e-91 276.0 COG0607@1|root,COG4275@1|root,COG0607@2|Bacteria,COG4275@2|Bacteria,1MYDE@1224|Proteobacteria,2TRC3@28211|Alphaproteobacteria,3JRCM@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P Chromate resistance exported protein - - - - - - - - - - - - Chrome_Resist,Rhodanese k59_1214164_3 697282.Mettu_2209 2.51e-19 86.3 COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,1RPNP@1236|Gammaproteobacteria,1XG1Z@135618|Methylococcales 135618|Methylococcales P Chromate transporter - - - - - - - - - - - - Chromate_transp k59_67707_1 1089439.KB902253_gene1433 5.71e-05 51.2 COG1192@1|root,COG1192@2|Bacteria,1RK00@1224|Proteobacteria 1224|Proteobacteria D Cellulose biosynthesis protein BcsQ - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_827517_2 1380394.JADL01000009_gene3415 1.88e-15 78.2 COG4583@1|root,COG4583@2|Bacteria,1N27A@1224|Proteobacteria,2U77J@28211|Alphaproteobacteria,2JU5Y@204441|Rhodospirillales 204441|Rhodospirillales E Sarcosine oxidase, gamma subunit family - - 1.5.3.1 ko:K00305 ko00260,ko01100,map00260,map01100 - R00610 RC00060,RC00557 ko00000,ko00001,ko01000 - - - SoxG k59_702646_1 1185766.DL1_12340 8.64e-08 52.8 COG0006@1|root,COG0006@2|Bacteria,1MVX5@1224|Proteobacteria,2TRMK@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Xaa-Pro aminopeptidase - - 3.4.13.9 ko:K01271 - - - - ko00000,ko01000,ko01002 - - - Creatinase_N,Peptidase_M24 k59_702646_2 196162.Noca_4475 3.41e-62 202.0 COG2084@1|root,COG2084@2|Bacteria,2GNB0@201174|Actinobacteria,4DTGW@85009|Propionibacteriales 201174|Actinobacteria I NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - 1.1.1.31 ko:K00020 ko00280,ko01100,map00280,map01100 - R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_532132_2 376686.Fjoh_5036 2.72e-14 69.7 COG4894@1|root,COG4894@2|Bacteria,4NK2I@976|Bacteroidetes,1ICNE@117743|Flavobacteriia,2NTRI@237|Flavobacterium 976|Bacteroidetes S Scramblase - - - - - - - - - - - - Scramblase k59_659404_1 376733.IT41_00195 1.06e-59 205.0 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQNK@28211|Alphaproteobacteria,2PVKP@265|Paracoccus 28211|Alphaproteobacteria G C4-dicarboxylate ABC transporter permease - - - - - - - - - - - - DctM k59_659404_2 28042.GU90_13130 1.78e-98 295.0 COG0846@1|root,COG0846@2|Bacteria,2GJI3@201174|Actinobacteria,4DZA5@85010|Pseudonocardiales 201174|Actinobacteria K Sir2 family cobB2 - - ko:K12410 - - - - ko00000,ko01000 - - - SIR2 k59_659404_3 420324.KI911970_gene1402 1.58e-13 68.6 COG4221@1|root,COG4221@2|Bacteria,1MWXS@1224|Proteobacteria,2TQYY@28211|Alphaproteobacteria,1JR5N@119045|Methylobacteriaceae 28211|Alphaproteobacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family MA20_32450 - - - - - - - - - - - adh_short k59_1000749_1 5872.XP_004828731.1 0.000234 48.9 COG2227@1|root,KOG1270@2759|Eukaryota,3YBWN@5794|Apicomplexa,3KB9A@422676|Aconoidasida,3Z3VB@5863|Piroplasmida 422676|Aconoidasida H O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway - - 2.1.1.114,2.1.1.222,2.1.1.64 ko:K00568,ko:K00591 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117,M00128 R02175,R04711,R04988,R05614,R07235,R08769,R08771,R08781 RC00003,RC00392,RC01895 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_23 k59_958281_1 1430440.MGMSRv2_3131 6.17e-37 135.0 COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,2TVFA@28211|Alphaproteobacteria,2JQEE@204441|Rhodospirillales 204441|Rhodospirillales S COG1253 Hemolysins and related proteins containing CBS domains - - - ko:K06189 - - - - ko00000,ko02000 9.A.40.1.2 - - CBS,CorC_HlyC k59_1126005_1 1472716.KBK24_0108845 1.5e-78 255.0 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2VIR8@28216|Betaproteobacteria,1K1ZS@119060|Burkholderiaceae 28216|Betaproteobacteria C Aldehyde oxidase and xanthine dehydrogenase coxL - 1.2.5.3 ko:K03520 - - R11168 RC02800 ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_103634_1 1462527.CCDM010000001_gene2670 5.86e-45 164.0 COG0028@1|root,COG0028@2|Bacteria,1TQE8@1239|Firmicutes,4H9VR@91061|Bacilli,23JE7@182709|Oceanobacillus 91061|Bacilli EH Thiamine pyrophosphate enzyme, central domain - - - - - - - - - - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_103635_1 1408419.JHYG01000007_gene2982 4.94e-22 93.2 COG0517@1|root,COG0517@2|Bacteria,1NY5H@1224|Proteobacteria,2U1GG@28211|Alphaproteobacteria 28211|Alphaproteobacteria S CBS domain - - - - - - - - - - - - BON,CBS k59_103635_2 1205680.CAKO01000007_gene4362 8.68e-65 205.0 COG1024@1|root,COG1024@2|Bacteria,1PSRK@1224|Proteobacteria,2U22I@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Enoyl-CoA hydratase - - - - - - - - - - - - ECH_1 k59_827607_1 443598.AUFA01000008_gene4106 2.29e-79 258.0 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria,3JUMW@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain coxL - 1.2.5.3 ko:K03520 - - R11168 RC02800 ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_915907_1 1121035.AUCH01000016_gene2118 3.11e-115 346.0 COG2010@1|root,COG2010@2|Bacteria,1N3PN@1224|Proteobacteria,2VHSF@28216|Betaproteobacteria,2KVT2@206389|Rhodocyclales 206389|Rhodocyclales C Cytochrome D1 heme domain nirS - 1.7.2.1,1.7.99.1 ko:K15864 ko00910,ko01120,map00910,map01120 M00529 R00143,R00783,R00785 RC00086,RC02797 ko00000,ko00001,ko00002,ko01000 - - - Cytochrom_D1,Cytochrome_CBB3 k59_67851_1 640081.Dsui_0810 1.86e-78 256.0 COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,2VIDI@28216|Betaproteobacteria,2KV2P@206389|Rhodocyclales 206389|Rhodocyclales T Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_146091_1 269796.Rru_A2404 1.09e-112 330.0 COG3954@1|root,COG3954@2|Bacteria,1MWN9@1224|Proteobacteria,2TSV4@28211|Alphaproteobacteria,2JRA2@204441|Rhodospirillales 204441|Rhodospirillales G Phosphoribulokinase cbbP - 2.7.1.19 ko:K00855 ko00710,ko01100,ko01120,ko01200,map00710,map01100,map01120,map01200 M00165,M00166 R01523 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - PRK k59_146091_2 1247726.MIM_c14320 2.31e-54 179.0 COG0191@1|root,COG0191@2|Bacteria,1MURX@1224|Proteobacteria,2VHGI@28216|Betaproteobacteria,3T1MN@506|Alcaligenaceae 28216|Betaproteobacteria G catalyzes the reversible aldol condensation of dihydroxyacetonephosphate and glyceraldehyde 3-phosphate in the Calvin cycle, glycolysis and gluconeogenesis cbbA - 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - F_bP_aldolase k59_745357_1 765912.Thimo_3207 4.06e-99 306.0 COG3261@1|root,COG3262@1|root,COG3261@2|Bacteria,COG3262@2|Bacteria,1QUBF@1224|Proteobacteria,1RSJ4@1236|Gammaproteobacteria,1WWJR@135613|Chromatiales 135613|Chromatiales C NADH dehydrogenase - - - - - - - - - - - - Complex1_30kDa,Complex1_49kDa,NiFeSe_Hases k59_792115_1 1177179.A11A3_15272 1.65e-27 114.0 COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,1RND5@1236|Gammaproteobacteria,1XHGC@135619|Oceanospirillales 135619|Oceanospirillales CH hydroxylase ubiF - - ko:K18800 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04987,R08768 RC00046 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_3 k59_323100_1 1454004.AW11_01223 4.28e-37 133.0 COG3332@1|root,COG3332@2|Bacteria,1RDBS@1224|Proteobacteria,2VQK6@28216|Betaproteobacteria,1KQTN@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria S Transport and Golgi organisation 2 - - - - - - - - - - - - TANGO2 k59_323100_2 1123393.KB891316_gene1405 4.08e-10 58.5 2EPNT@1|root,33H9E@2|Bacteria,1NI6Z@1224|Proteobacteria,2WCD0@28216|Betaproteobacteria,1KTFV@119069|Hydrogenophilales 119069|Hydrogenophilales S Domain of unknown function (DUF4936) - - - - - - - - - - - - DUF4936 k59_323100_3 1031711.RSPO_c01815 1.11e-38 148.0 COG0354@1|root,COG0354@2|Bacteria,1N852@1224|Proteobacteria,2VK2D@28216|Betaproteobacteria,1K0KG@119060|Burkholderiaceae 28216|Betaproteobacteria S Belongs to the GcvT family ygfZ - - ko:K06980 - - - - ko00000,ko03016 - - - GCV_T,GCV_T_C k59_146156_1 666681.M301_2616 7.37e-17 86.3 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,2VHY8@28216|Betaproteobacteria,2KKXA@206350|Nitrosomonadales 206350|Nitrosomonadales NU Neisseria PilC beta-propeller domain - - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC k59_1048718_1 391615.ABSJ01000026_gene121 4.91e-31 122.0 2CIBN@1|root,2Z8JT@2|Bacteria,1R902@1224|Proteobacteria,1RXPM@1236|Gammaproteobacteria,1J8X1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Metal dependent phosphohydrolases with conserved 'HD' motif. - - - - - - - - - - - - - k59_1048718_2 1500304.JQKY01000004_gene1347 9.53e-74 236.0 COG0265@1|root,COG0265@2|Bacteria,1MURF@1224|Proteobacteria,2TUVW@28211|Alphaproteobacteria,4B76P@82115|Rhizobiaceae 28211|Alphaproteobacteria O Trypsin-like peptidase domain MA20_20705 - - - - - - - - - - - PDZ_2,Trypsin_2 k59_1048718_3 1218075.BAYA01000014_gene4146 1.43e-64 209.0 COG3568@1|root,COG3568@2|Bacteria,1R9NP@1224|Proteobacteria,2WGEU@28216|Betaproteobacteria,1K0J8@119060|Burkholderiaceae 28216|Betaproteobacteria L endonuclease - - - - - - - - - - - - Exo_endo_phos k59_745479_1 266809.PM03_10515 2.6e-70 222.0 COG3181@1|root,COG3181@2|Bacteria,1MXEX@1224|Proteobacteria,2TT5Y@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Tripartite tricarboxylate transporter family receptor - - - - - - - - - - - - TctC k59_870693_1 59538.XP_005974968.1 4.96e-98 305.0 COG0578@1|root,KOG0042@2759|Eukaryota,38FKM@33154|Opisthokonta,3BB5T@33208|Metazoa,3CRJI@33213|Bilateria,48928@7711|Chordata,493F8@7742|Vertebrata,3J5AP@40674|Mammalia,4IWKX@91561|Cetartiodactyla 2759|Eukaryota C Glycerol-3-phosphate dehydrogenase - - 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - DAO,DAO_C k59_622281_1 631454.N177_1280 4.63e-51 167.0 COG0127@1|root,COG0127@2|Bacteria,1MUK5@1224|Proteobacteria,2TV4B@28211|Alphaproteobacteria,1JNQZ@119043|Rhodobiaceae 28211|Alphaproteobacteria F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions rdgB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 ko:K02428 ko00230,map00230 - R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000 - - - Ham1p_like k59_745522_1 391165.GbCGDNIH1_0706 3.97e-12 71.2 COG0457@1|root,COG0457@2|Bacteria,1RK4Q@1224|Proteobacteria,2UBBB@28211|Alphaproteobacteria,2JSKY@204441|Rhodospirillales 204441|Rhodospirillales S COG0457 FOG TPR repeat - - - - - - - - - - - - TPR_16,TPR_9 k59_68021_1 1095769.CAHF01000001_gene3558 1.95e-64 213.0 COG3540@1|root,COG3540@2|Bacteria,1MWAF@1224|Proteobacteria,2VKX4@28216|Betaproteobacteria,473NS@75682|Oxalobacteraceae 28216|Betaproteobacteria P PhoD-like phosphatase phoD2 - 3.1.3.1 ko:K01113 ko00790,ko01100,ko02020,map00790,map01100,map02020 M00126 R04620 RC00017 ko00000,ko00001,ko00002,ko01000 - - - PhoD,PhoD_N k59_1001025_1 288000.BBta_p0210 1.85e-103 304.0 COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,3JZ81@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L Evidence Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - HTH_21,rve_3 k59_489787_1 1502724.FF80_02816 0.000992 42.4 COG3703@1|root,COG3703@2|Bacteria,1RKPP@1224|Proteobacteria,2UBDI@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides - - - ko:K07232 - - - - ko00000 - - - ChaC k59_489787_2 316067.Geob_2506 1.68e-66 216.0 COG1168@1|root,COG1168@2|Bacteria,1MY33@1224|Proteobacteria,42M6F@68525|delta/epsilon subdivisions,2WK37@28221|Deltaproteobacteria 28221|Deltaproteobacteria E PFAM aminotransferase class I and II - - 4.4.1.8 ko:K14155 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 - R00782,R01286,R02408,R04941 RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_1091247_1 77586.LPERR01G10100.1 4.32e-27 110.0 COG0119@1|root,COG5044@1|root,KOG2368@2759|Eukaryota,KOG4405@2759|Eukaryota,37RZC@33090|Viridiplantae,3H075@35493|Streptophyta,3KXZD@4447|Liliopsida,3IEKD@38820|Poales 35493|Streptophyta TU GDP dissociation inhibitor - - - - - - - - - - - - GDI k59_950877_3 1100720.ALKN01000035_gene980 3.41e-121 352.0 COG0235@1|root,COG0235@2|Bacteria,1MWP9@1224|Proteobacteria,2VN0U@28216|Betaproteobacteria,4AI0K@80864|Comamonadaceae 28216|Betaproteobacteria G Class II Aldolase and Adducin N-terminal domain - - - - - - - - - - - - Aldolase_II k59_950877_4 710685.MycrhN_4175 9.57e-09 57.0 COG0596@1|root,COG0596@2|Bacteria,2GMMB@201174|Actinobacteria,233I2@1762|Mycobacteriaceae 201174|Actinobacteria S Alpha beta hydrolase ephB GO:0003674,GO:0003824,GO:0004301,GO:0005488,GO:0005515,GO:0016787,GO:0016801,GO:0016803,GO:0018742,GO:0042802,GO:0042803,GO:0046983 - - - - - - - - - - Abhydrolase_1 k59_482084_1 944435.AXAJ01000001_gene689 1.58e-11 65.1 COG0715@1|root,COG0715@2|Bacteria,1PKQN@1224|Proteobacteria,2WBCE@28216|Betaproteobacteria,1K5QB@119060|Burkholderiaceae 1224|Proteobacteria P 4,5-dihydroxyphthalate decarboxylase - - - - - - - - - - - - - k59_482084_2 1437824.BN940_08521 4.08e-36 132.0 COG2084@1|root,COG2084@2|Bacteria,1MX8V@1224|Proteobacteria,2VMCM@28216|Betaproteobacteria,3T4CS@506|Alcaligenaceae 28216|Betaproteobacteria I Domain of unknown function (DUF1932) - - 1.1.1.31 ko:K00020 ko00280,ko01100,map00280,map01100 - R05066 RC00099 ko00000,ko00001,ko01000 - - - DUF1932,NAD_binding_2 k59_821232_1 426355.Mrad2831_0214 0.000594 40.8 COG0745@1|root,COG0745@2|Bacteria,1RD7E@1224|Proteobacteria,2UD5E@28211|Alphaproteobacteria,1JV34@119045|Methylobacteriaceae 28211|Alphaproteobacteria T cheY-homologous receiver domain - - - - - - - - - - - - Response_reg k59_821232_2 483219.LILAB_12790 2.72e-34 134.0 COG0642@1|root,COG0784@1|root,COG0840@1|root,COG1511@1|root,COG2199@1|root,COG2770@1|root,COG0784@2|Bacteria,COG0840@2|Bacteria,COG1511@2|Bacteria,COG2205@2|Bacteria,COG2770@2|Bacteria,COG3706@2|Bacteria,1NRP8@1224|Proteobacteria,42MW4@68525|delta/epsilon subdivisions,2WKWD@28221|Deltaproteobacteria,2Z3GS@29|Myxococcales 28221|Deltaproteobacteria T Histidine kinase - - - - - - - - - - - - 4HB_MCP_1,GAF_2,HAMP,HATPase_c,HisKA,Response_reg k59_1164121_1 94624.Bpet1285 2.89e-32 122.0 COG1028@1|root,COG1028@2|Bacteria,1RG9P@1224|Proteobacteria,2VRJZ@28216|Betaproteobacteria,3T8Z4@506|Alcaligenaceae 28216|Betaproteobacteria IQ Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - - - - - - - - - - adh_short_C2 k59_1291506_1 485913.Krac_5076 1.65e-63 214.0 COG0243@1|root,COG0243@2|Bacteria,2G5X7@200795|Chloroflexi 485913.Krac_5076|- C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - - - - - - - - - - - k59_396627_1 1227457.C451_04913 4.33e-19 91.7 COG2304@1|root,arCOG07611@1|root,arCOG02902@2157|Archaea,arCOG07611@2157|Archaea,2Y8GQ@28890|Euryarchaeota 28890|Euryarchaeota M Domain of unknown function DUF11 - - - - - - - - - - - - DUF11 k59_737899_1 28229.ND2E_3969 1.39e-06 52.8 COG0697@1|root,COG0697@2|Bacteria,1P3V0@1224|Proteobacteria,1RW4A@1236|Gammaproteobacteria,2Q8D9@267889|Colwelliaceae 1236|Gammaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA k59_737899_2 89187.ISM_05570 8.81e-10 60.8 COG1028@1|root,COG1028@2|Bacteria,1MXVZ@1224|Proteobacteria,2TSQ4@28211|Alphaproteobacteria,46NB3@74030|Roseovarius 28211|Alphaproteobacteria IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_139579_1 69328.PVLB_14855 6.03e-36 125.0 COG3558@1|root,COG3558@2|Bacteria,1RA64@1224|Proteobacteria,1S252@1236|Gammaproteobacteria 1236|Gammaproteobacteria S 50S ribosomal protein L21 - - - ko:K09958 - - - - ko00000 - - - DUF1348 k59_139579_2 1316932.MHH_c00630 1.92e-14 74.7 COG1335@1|root,COG1335@2|Bacteria,1N48X@1224|Proteobacteria,1S00N@1236|Gammaproteobacteria,1Y9ED@135625|Pasteurellales 135625|Pasteurellales Q Isochorismatase family - - - - - - - - - - - - Isochorismatase k59_97141_1 1235457.C404_19325 2.4e-61 212.0 COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,2VH05@28216|Betaproteobacteria,1K4Q5@119060|Burkholderiaceae 28216|Betaproteobacteria EI Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly icmF GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0006139,GO:0006163,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016866,GO:0017076,GO:0017111,GO:0019001,GO:0019637,GO:0019693,GO:0019842,GO:0031419,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0034784,GO:0035383,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043603,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046872,GO:0046906,GO:0047727,GO:0048037,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564 5.4.99.13 ko:K11942 - - - - ko00000,ko01000 - - - ArgK,B12-binding,MM_CoA_mutase k59_439529_2 1122236.KB905141_gene1811 6.32e-26 99.4 COG4654@1|root,COG4654@2|Bacteria,1N6UN@1224|Proteobacteria,2VW1Y@28216|Betaproteobacteria,2KMZ0@206350|Nitrosomonadales 206350|Nitrosomonadales C PFAM cytochrome c, class I - - - ko:K08738 ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 3.D.4.6 - - Cytochrom_C,Cytochrome_CBB3 k59_439529_3 1121106.JQKB01000006_gene1308 4.61e-20 87.8 COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,2TSDS@28211|Alphaproteobacteria,2JQSZ@204441|Rhodospirillales 204441|Rhodospirillales E Belongs to the binding-protein-dependent transport system permease family livH - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_783001_1 1163389.OOM_0329 0.000152 49.3 COG2885@1|root,COG2885@2|Bacteria,1R4WG@1224|Proteobacteria,1RZN8@1236|Gammaproteobacteria,460YY@72273|Thiotrichales 72273|Thiotrichales M Belongs to the ompA family - - - - - - - - - - - - OmpA k59_482159_2 316055.RPE_4546 4.74e-80 258.0 COG0318@1|root,COG0318@2|Bacteria,1MUMC@1224|Proteobacteria,2TTMQ@28211|Alphaproteobacteria,3JU68@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria IQ AMP-binding enzyme C-terminal domain MA20_26770 - 6.2.1.44 ko:K20034 ko00920,map00920 - R10820 RC00004,RC00014 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C k59_1119747_1 426114.THI_3126 3.41e-25 107.0 COG0642@1|root,COG0642@2|Bacteria,1PA1G@1224|Proteobacteria,2VHX5@28216|Betaproteobacteria 28216|Betaproteobacteria T Histidine kinase - - 2.7.13.1 ko:K05962 - - - - ko00000,ko01000 - - - HAMP,HATPase_c,HisKA k59_1119747_2 227377.CBU_2006 4.2e-10 59.3 COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,1RPKN@1236|Gammaproteobacteria,1JCWX@118969|Legionellales 118969|Legionellales K Transcriptional regulatory protein, C terminal ompR - - ko:K02483 - - - - ko00000,ko02022 - - - Response_reg,Trans_reg_C k59_226150_1 1126627.BAWE01000005_gene6387 1.06e-21 96.7 COG2084@1|root,COG2084@2|Bacteria,1MX8V@1224|Proteobacteria,2TVBS@28211|Alphaproteobacteria,3JUVX@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I Domain of unknown function (DUF1932) - - - - - - - - - - - - DUF1932,NAD_binding_2 k59_226150_2 1123072.AUDH01000001_gene2811 7.89e-14 69.7 COG3836@1|root,COG3836@2|Bacteria,1MUSG@1224|Proteobacteria,2TT2W@28211|Alphaproteobacteria,2JS3C@204441|Rhodospirillales 204441|Rhodospirillales G Belongs to the HpcH HpaI aldolase family - - 2.7.7.38,4.1.2.52 ko:K00979,ko:K02510 ko00350,ko00540,ko01100,ko01120,map00350,map00540,map01100,map01120 M00063 R01645,R01647,R03351,R11396 RC00152,RC00307,RC00572,RC00574,RC00910,RC03057 ko00000,ko00001,ko00002,ko01000,ko01005 - - - HpcH_HpaI k59_226170_1 269799.Gmet_2580 4.05e-88 290.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,42P3V@68525|delta/epsilon subdivisions,2WKWV@28221|Deltaproteobacteria,43TF0@69541|Desulfuromonadales 28221|Deltaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA1 - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_58719_1 1121033.AUCF01000013_gene1589 1.92e-75 243.0 COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,2TTUP@28211|Alphaproteobacteria,2JRGM@204441|Rhodospirillales 204441|Rhodospirillales F Belongs to the 5'-nucleotidase family - - 3.1.3.5,3.6.1.45 ko:K01081,ko:K11751 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - 5_nucleotid_C,Metallophos k59_15241_2 269796.Rru_A3480 1.16e-32 124.0 COG0624@1|root,COG0624@2|Bacteria,1MW6G@1224|Proteobacteria,2TT0J@28211|Alphaproteobacteria,2JQ29@204441|Rhodospirillales 204441|Rhodospirillales E Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls dapE - 3.5.1.18 ko:K01439 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R02734 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20 k59_908505_1 279714.FuraDRAFT_2280 1.36e-13 69.3 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2VHRB@28216|Betaproteobacteria,2KQBY@206351|Neisseriales 206351|Neisseriales V ABC transporter - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3,ABC_tran k59_908505_2 762376.AXYL_03492 1.32e-44 155.0 COG1566@1|root,COG1566@2|Bacteria,1QUDS@1224|Proteobacteria,2WHE9@28216|Betaproteobacteria,3T73T@506|Alcaligenaceae 28216|Betaproteobacteria V COG0845 Membrane-fusion protein - - - ko:K01993 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3 k59_951006_2 1121935.AQXX01000108_gene451 7.12e-68 221.0 COG3203@1|root,COG3203@2|Bacteria,1RIIY@1224|Proteobacteria,1T112@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Gram-negative porin - - - - - - - - - - - - Porin_4 k59_1291592_1 983920.Y88_0535 1.77e-21 85.5 COG0636@1|root,COG0636@2|Bacteria,1NAIE@1224|Proteobacteria,2UBRD@28211|Alphaproteobacteria,2K7IN@204457|Sphingomonadales 204457|Sphingomonadales C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation - - - ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_C k59_1291592_2 595460.RRSWK_00685 2.1e-09 62.8 COG0711@1|root,COG0711@2|Bacteria,2IZ3I@203682|Planctomycetes 203682|Planctomycetes C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) - - - ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_B k59_1206938_1 640512.BC1003_1148 2.84e-91 287.0 COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,2VHPQ@28216|Betaproteobacteria,1K0UB@119060|Burkholderiaceae 28216|Betaproteobacteria E PFAM peptidase M3A and M3B, thimet oligopeptidase F prlC - 3.4.24.70 ko:K01414 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3 k59_695452_1 1000565.METUNv1_03030 4.76e-82 256.0 COG2067@1|root,COG2067@2|Bacteria,1MV7W@1224|Proteobacteria,2VKWX@28216|Betaproteobacteria,2KW3I@206389|Rhodocyclales 206389|Rhodocyclales I Outer membrane protein transport protein (OMPP1/FadL/TodX) - - - ko:K06076 - - - - ko00000,ko02000 1.B.9 - - Toluene_X k59_139684_1 1123368.AUIS01000021_gene987 3.27e-97 293.0 COG0725@1|root,COG0725@2|Bacteria,1NACV@1224|Proteobacteria,1T2QW@1236|Gammaproteobacteria,2ND9P@225057|Acidithiobacillales 225057|Acidithiobacillales P Bacterial extracellular solute-binding protein - - - - - - - - - - - - SBP_bac_11 k59_783136_1 639030.JHVA01000001_gene709 2.62e-05 52.4 COG3437@1|root,COG5002@1|root,COG3437@2|Bacteria,COG5002@2|Bacteria,3Y3RN@57723|Acidobacteria,2JHP1@204432|Acidobacteriia 204432|Acidobacteriia T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,Response_reg k59_1206999_1 595537.Varpa_2120 3.9e-20 89.0 COG1024@1|root,COG1024@2|Bacteria,1MXBB@1224|Proteobacteria,2VICM@28216|Betaproteobacteria,4AD3D@80864|Comamonadaceae 28216|Betaproteobacteria I Enoyl-CoA hydratase carnithine racemase - - - - - - - - - - - - ECH_1 k59_1206999_2 1120948.KB903218_gene2081 3.32e-14 72.4 COG0596@1|root,COG0596@2|Bacteria,2GNFU@201174|Actinobacteria,4E1VI@85010|Pseudonocardiales 201174|Actinobacteria S Serine aminopeptidase, S33 - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_1164333_1 94624.Bpet3017 4.22e-91 286.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2VI6G@28216|Betaproteobacteria,3T1SX@506|Alcaligenaceae 28216|Betaproteobacteria C Pyruvate 2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3) component and related enzymes lpdA GO:0003674,GO:0003824,GO:0004148,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006139,GO:0006163,GO:0006164,GO:0006464,GO:0006637,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0018130,GO:0018335,GO:0019362,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0019752,GO:0031974,GO:0031981,GO:0032787,GO:0032991,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0036211,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043436,GO:0043543,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0046390,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0061732,GO:0070013,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0072524,GO:0090407,GO:0106077,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902494,GO:1990204,GO:1990234 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim k59_183924_1 1500894.JQNN01000001_gene3978 0.000211 43.5 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,2VHXF@28216|Betaproteobacteria,473GW@75682|Oxalobacteraceae 28216|Betaproteobacteria M Penicillin-binding protein OB-like domain mrcA - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - PCB_OB,Transgly,Transpeptidase k59_183924_2 522306.CAP2UW1_4189 2.72e-20 89.4 COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,2VH6W@28216|Betaproteobacteria 28216|Betaproteobacteria NU Type IV pilus assembly protein PilM pilM - - ko:K02662 - - - - ko00000,ko02035,ko02044 - - - PilM_2 k59_482342_1 580332.Slit_1833 2.75e-42 149.0 COG0604@1|root,COG0604@2|Bacteria,1MV3W@1224|Proteobacteria,2VINX@28216|Betaproteobacteria,44WDD@713636|Nitrosomonadales 28216|Betaproteobacteria C PFAM Alcohol dehydrogenase GroES domain protein - - - - - - - - - - - - ADH_N,ADH_zinc_N k59_482342_2 630626.EBL_c21270 5.09e-10 60.1 COG2079@1|root,COG2079@2|Bacteria,1MUIG@1224|Proteobacteria,1RPQN@1236|Gammaproteobacteria 1236|Gammaproteobacteria S 2-methylcitrate dehydratase prpD GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017001,GO:0017144,GO:0019541,GO:0019543,GO:0019626,GO:0019629,GO:0019679,GO:0019752,GO:0032787,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0046459,GO:0047547,GO:0048037,GO:0051536,GO:0051537,GO:0051540,GO:0071704,GO:0072329,GO:1901575 4.2.1.79 ko:K01720 ko00640,map00640 - R04424 RC01152 ko00000,ko00001,ko01000 - - iEcolC_1368.EcolC_3291 MmgE_PrpD k59_525029_1 232721.Ajs_1824 1.47e-113 340.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2VI6G@28216|Betaproteobacteria,4AB65@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase odhL GO:0003674,GO:0003824,GO:0004148,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006139,GO:0006163,GO:0006164,GO:0006464,GO:0006637,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0018130,GO:0018335,GO:0019362,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0019752,GO:0031974,GO:0031981,GO:0032787,GO:0032991,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0036211,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043436,GO:0043543,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0046390,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0061732,GO:0070013,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0072524,GO:0090407,GO:0106077,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902494,GO:1990204,GO:1990234 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim k59_525029_2 1163409.UUA_14694 1.27e-17 78.6 COG3260@1|root,COG3260@2|Bacteria,1QUBE@1224|Proteobacteria,1RNUG@1236|Gammaproteobacteria,1XATD@135614|Xanthomonadales 135614|Xanthomonadales C NADH ubiquinone oxidoreductase, 20 Kd subunit - - - - - - - - - - - - Oxidored_q6 k59_613404_2 1123059.KB823013_gene487 3.25e-48 167.0 COG4244@1|root,COG4244@2|Bacteria,1RK8N@1224|Proteobacteria,2VG0D@28211|Alphaproteobacteria,4413H@69657|Hyphomonadaceae 28211|Alphaproteobacteria S Predicted membrane protein (DUF2231) - - - - - - - - - - - - DUF2231,SnoaL_3 k59_908641_2 926549.KI421517_gene2514 0.000825 47.0 COG5362@1|root,COG5410@1|root,COG5362@2|Bacteria,COG5410@2|Bacteria,4NN30@976|Bacteroidetes,47TVV@768503|Cytophagia 976|Bacteroidetes S Terminase RNaseH-like domain - - - - - - - - - - - - Terminase_6,Terminase_6C k59_1039874_1 1157708.KB907457_gene2757 3.32e-42 145.0 COG0204@1|root,COG0204@2|Bacteria,1RA8V@1224|Proteobacteria,2VQ8G@28216|Betaproteobacteria,4ABCG@80864|Comamonadaceae 28216|Betaproteobacteria I PFAM phospholipid glycerol acyltransferase - - 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_1039874_2 311403.Arad_3662 4.98e-41 145.0 COG4589@1|root,COG4589@2|Bacteria,1MX58@1224|Proteobacteria,2TT9I@28211|Alphaproteobacteria,4B892@82115|Rhizobiaceae 28211|Alphaproteobacteria S Phosphatidate cytidylyltransferase cdsA2 - 2.7.7.41 ko:K00981 ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 M00093 R01799 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_1 k59_566126_1 1117314.PCIT_00643 4.29e-11 62.4 COG1018@1|root,COG1018@2|Bacteria,1MW37@1224|Proteobacteria,1RR95@1236|Gammaproteobacteria,2Q002@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria C COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 fpr GO:0000166,GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004324,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006000,GO:0006001,GO:0006790,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0010035,GO:0016043,GO:0016052,GO:0016226,GO:0016491,GO:0016730,GO:0016731,GO:0019318,GO:0019320,GO:0022607,GO:0031163,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0044085,GO:0044237,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051186,GO:0055114,GO:0071704,GO:0071840,GO:0071949,GO:0097159,GO:1901265,GO:1901363,GO:1901575,GO:1901700 1.18.1.2,1.19.1.1 ko:K00528 - - R10159 - ko00000,ko01000 - - iECIAI39_1322.ECIAI39_3072,iEcSMS35_1347.EcSMS35_4364,iYL1228.KPN_04002 FAD_binding_6,NAD_binding_1 k59_566126_2 1123072.AUDH01000011_gene3630 2.51e-42 146.0 COG0251@1|root,COG0251@2|Bacteria,1N1B6@1224|Proteobacteria,2TZWE@28211|Alphaproteobacteria 28211|Alphaproteobacteria J oxidation-reduction process MA20_16785 - - - - - - - - - - - - k59_97341_2 1318628.MARLIPOL_02875 6.63e-29 113.0 COG0309@1|root,COG0309@2|Bacteria,1MVCC@1224|Proteobacteria,1RQBE@1236|Gammaproteobacteria,466Z8@72275|Alteromonadaceae 1236|Gammaproteobacteria O AIR synthase related protein, N-terminal domain hypE GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0018193,GO:0018198,GO:0018249,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046892,GO:0051604,GO:0071704,GO:1901564 - ko:K04655 - - - - ko00000 - - - AIRS,AIRS_C k59_58948_1 314287.GB2207_07617 2.83e-75 236.0 COG4221@1|root,COG4221@2|Bacteria,1QTXF@1224|Proteobacteria 1224|Proteobacteria S short-chain dehydrogenase - - - - - - - - - - - - adh_short_C2 k59_821504_1 290397.Adeh_1659 7.67e-80 251.0 COG3005@1|root,COG3005@2|Bacteria,1R956@1224|Proteobacteria,42Q0X@68525|delta/epsilon subdivisions,2WMHI@28221|Deltaproteobacteria 28221|Deltaproteobacteria C NapC/NirT cytochrome c family, N-terminal region - GO:0003674,GO:0003824,GO:0005575,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0031224,GO:0044237,GO:0044425,GO:0045333,GO:0055114 - - - - - - - - - - Cytochrom_NNT k59_1249799_1 153948.NAL212_1749 4.76e-27 116.0 COG2202@1|root,COG3920@1|root,COG2202@2|Bacteria,COG3920@2|Bacteria,1MVPJ@1224|Proteobacteria,2VN2J@28216|Betaproteobacteria,373UM@32003|Nitrosomonadales 28216|Betaproteobacteria T PFAM Signal transduction histidine kinase, subgroup 2, dimerisation and phosphoacceptor - - - - - - - - - - - - HATPase_c,HATPase_c_2,HisKA_2,PAS,PAS_4,PAS_9 k59_613485_1 941449.dsx2_1962 6.86e-39 142.0 COG1159@1|root,COG1159@2|Bacteria,1MUKT@1224|Proteobacteria,42MUR@68525|delta/epsilon subdivisions,2WJC8@28221|Deltaproteobacteria,2M8A4@213115|Desulfovibrionales 28221|Deltaproteobacteria S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism era - - ko:K03595 - - - - ko00000,ko03009,ko03029 - - - KH_2,MMR_HSR1 k59_15463_1 1121035.AUCH01000003_gene1185 3.5e-13 67.4 COG2854@1|root,COG2854@2|Bacteria,1NKFA@1224|Proteobacteria,2VR85@28216|Betaproteobacteria,2KW7C@206389|Rhodocyclales 206389|Rhodocyclales Q ABC-type transport system involved in resistance to organic solvents, auxiliary component - - - ko:K07323 ko02010,map02010 M00210 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27.3 - - MlaC k59_15463_2 640081.Dsui_1403 6.64e-17 76.3 COG3113@1|root,COG3113@2|Bacteria,1PJKD@1224|Proteobacteria,2VW6E@28216|Betaproteobacteria,2KXIR@206389|Rhodocyclales 206389|Rhodocyclales S STAS domain - - - ko:K07122 ko02010,map02010 M00210 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27.3 - - STAS_2 k59_15464_2 314345.SPV1_12617 2.78e-55 188.0 COG0189@1|root,COG0189@2|Bacteria,1MX5X@1224|Proteobacteria 1224|Proteobacteria HJ Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase) rimK - - - - - - - - - - - Dala_Dala_lig_C,RLAN,RimK k59_1164463_1 1470591.BW41_02187 1.16e-17 85.9 COG0642@1|root,COG2205@2|Bacteria,1MW8M@1224|Proteobacteria,2TSD2@28211|Alphaproteobacteria,2KCJZ@204457|Sphingomonadales 204457|Sphingomonadales T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - - - - - - - - - - HATPase_c k59_59010_2 748247.AZKH_4600 9.52e-56 185.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VKD8@28216|Betaproteobacteria,2KV57@206389|Rhodocyclales 206389|Rhodocyclales T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activ_2 k59_315193_1 545695.TREAZ_3386 0.000126 50.4 COG0683@1|root,COG0683@2|Bacteria,2J62Q@203691|Spirochaetes 203691|Spirochaetes E PFAM Receptor family ligand binding region - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_15502_1 1100720.ALKN01000033_gene658 2.75e-118 348.0 COG2133@1|root,COG2133@2|Bacteria,1MVK5@1224|Proteobacteria,2VIRC@28216|Betaproteobacteria,4ACEX@80864|Comamonadaceae 28216|Betaproteobacteria G Glucose / Sorbosone dehydrogenase - - - - - - - - - - - - GSDH,SGL k59_59056_1 748247.AZKH_4280 3.12e-98 295.0 COG0583@1|root,COG0583@2|Bacteria,1MU8N@1224|Proteobacteria,2VHQY@28216|Betaproteobacteria,2KURX@206389|Rhodocyclales 206389|Rhodocyclales K Transcriptional regulator cysB - - ko:K13634 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate k59_951285_1 745014.OMB55_00017870 7.2e-77 242.0 COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,1RMAW@1236|Gammaproteobacteria,1J4TG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Belongs to the CarA family carA GO:0000050,GO:0003674,GO:0003824,GO:0004088,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0032991,GO:0034641,GO:0034654,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0055086,GO:0071704,GO:0071941,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_1950,iUTI89_1310.UTI89_C0036,ic_1306.c0040 CPSase_sm_chain,GATase k59_652742_2 1089552.KI911559_gene2017 4.85e-39 131.0 COG2963@1|root,COG2963@2|Bacteria,1RGZ5@1224|Proteobacteria,2UAIS@28211|Alphaproteobacteria,2JT7W@204441|Rhodospirillales 204441|Rhodospirillales L Transposase - - - - - - - - - - - - HTH_Tnp_1 k59_1082454_1 314285.KT71_06504 2.43e-55 187.0 COG1020@1|root,COG1020@2|Bacteria,1N7HY@1224|Proteobacteria,1SMER@1236|Gammaproteobacteria,1J8V8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Protein of unknown function (DUF1298) - - - - - - - - - - - - DUF1298,WES_acyltransf k59_1207210_2 661087.HMPREF1008_01721 0.000822 43.9 COG0514@1|root,COG0608@1|root,COG0514@2|Bacteria,COG0608@2|Bacteria,2IK2U@201174|Actinobacteria,4CUF5@84998|Coriobacteriia 84998|Coriobacteriia L single-stranded-DNA-specific exonuclease RecJ recJ - - ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,DHH,DHHA1,Helicase_C k59_1164544_1 521674.Plim_1354 2.5e-13 67.0 2BWS9@1|root,33DSN@2|Bacteria,2J18N@203682|Planctomycetes 203682|Planctomycetes - - - - - - - - - - - - - - - k59_482521_1 765177.Desmu_0868 9.9e-71 223.0 COG0451@1|root,arCOG04468@2157|Archaea,2XPTA@28889|Crenarchaeota 28889|Crenarchaeota M PFAM NAD-dependent epimerase dehydratase - - - - - - - - - - - - Epimerase k59_397030_1 545276.KB898727_gene300 2.58e-52 186.0 COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,1RMQE@1236|Gammaproteobacteria,1WXF0@135613|Chromatiales 135613|Chromatiales K 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs rnr - - ko:K12573 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03016,ko03019 - - - HTH_12,OB_RNB,RNB,S1 k59_1164550_1 562970.Btus_1715 2.02e-47 166.0 COG0128@1|root,COG0128@2|Bacteria,1TPIH@1239|Firmicutes,4HBHZ@91061|Bacilli,278T4@186823|Alicyclobacillaceae 91061|Bacilli E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate aroA GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576 2.5.1.19 ko:K00800 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03460 RC00350 ko00000,ko00001,ko00002,ko01000 - - - EPSP_synthase k59_1164550_2 1123284.KB899044_gene683 1.05e-17 81.6 COG0283@1|root,COG0283@2|Bacteria,1V3IA@1239|Firmicutes,4HFZE@91061|Bacilli,26NTN@186821|Sporolactobacillaceae 91061|Bacilli F Cytidylate kinase-like family cmk GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.4.25 ko:K00945 ko00240,ko01100,map00240,map01100 M00052 R00158,R00512,R01665 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Cytidylate_kin k59_1207233_1 1266925.JHVX01000018_gene1825 1.4e-102 307.0 COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,2VH5D@28216|Betaproteobacteria,372HU@32003|Nitrosomonadales 28216|Betaproteobacteria J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 k59_955499_2 187272.Mlg_1537 3.9e-14 67.0 COG4877@1|root,COG4877@2|Bacteria,1NNE2@1224|Proteobacteria,1SGNK@1236|Gammaproteobacteria,1WZNZ@135613|Chromatiales 135613|Chromatiales S Ribbon-helix-helix protein, copG family - - - - - - - - - - - - RHH_1,RHH_5 k59_868068_1 1266925.JHVX01000004_gene1197 6.22e-56 197.0 COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,2VIWI@28216|Betaproteobacteria,3728T@32003|Nitrosomonadales 28216|Betaproteobacteria S PFAM Peptidase S45, penicillin amidase - - 3.5.1.11 ko:K01434 ko00311,ko01130,map00311,map01130 - R02170 RC00166,RC00328 ko00000,ko00001,ko01000,ko01002 - - - Penicil_amidase k59_1342834_1 686340.Metal_2543 5.32e-57 190.0 COG0055@1|root,COG0055@2|Bacteria,1N6UZ@1224|Proteobacteria,1RNQW@1236|Gammaproteobacteria,1XDWQ@135618|Methylococcales 135618|Methylococcales C PFAM ATPase, F1 V1 A1 complex, alpha beta subunit, nucleotide-binding domain - - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N k59_401276_1 580332.Slit_0323 1.52e-21 99.8 2DBUQ@1|root,2ZB76@2|Bacteria,1R4DM@1224|Proteobacteria,2VP87@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_230450_1 883080.HMPREF9697_01752 1.89e-17 80.1 COG2030@1|root,COG2030@2|Bacteria,1NYEM@1224|Proteobacteria,2U0F4@28211|Alphaproteobacteria,3JVIY@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I dehydratase MA20_27475 - - - - - - - - - - - - k59_230450_2 258594.RPA4520 2.09e-41 144.0 COG0494@1|root,COG0494@2|Bacteria,1QXZR@1224|Proteobacteria,2TXF1@28211|Alphaproteobacteria,3K6UE@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L NUDIX domain - - - - - - - - - - - - NUDIX k59_788661_1 288000.BBta_3437 7.69e-34 133.0 COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,2TTJZ@28211|Alphaproteobacteria,3JVPM@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria V FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_64354_1 1207055.C100_18340 2.04e-10 61.2 COG2197@1|root,COG2197@2|Bacteria,1P4TD@1224|Proteobacteria,2U06A@28211|Alphaproteobacteria,2KCQ4@204457|Sphingomonadales 204457|Sphingomonadales T helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg k59_443678_2 240015.ACP_2983 5.08e-47 170.0 COG0653@1|root,COG0653@2|Bacteria,3Y34P@57723|Acidobacteria,2JHSP@204432|Acidobacteriia 204432|Acidobacteriia U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_867749_1 272560.BPSS0322 5.21e-42 151.0 COG1139@1|root,COG1139@2|Bacteria,1MV6J@1224|Proteobacteria,2VJ3Y@28216|Betaproteobacteria,1K2Z6@119060|Burkholderiaceae 28216|Betaproteobacteria C LUD domain - - - ko:K18929 - - - - ko00000 - - - DUF3390,Fer4_8,LUD_dom k59_867749_2 331869.BAL199_11151 8.29e-29 110.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,2TR9H@28211|Alphaproteobacteria,4BPCH@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria C Cysteine-rich domain - - - ko:K18928 - - - - ko00000 - - - CCG k59_1168368_1 614083.AWQR01000029_gene2143 3.03e-07 51.2 COG3825@1|root,COG3825@2|Bacteria,1MUAJ@1224|Proteobacteria,2VJ99@28216|Betaproteobacteria,4AAR6@80864|Comamonadaceae 28216|Betaproteobacteria S VWA domain containing CoxE-like protein - - - ko:K09989 - - - - ko00000 - - - VWA_CoxE k59_1168368_2 1031711.RSPO_c00341 8.46e-108 320.0 COG1028@1|root,COG1028@2|Bacteria,1MUWC@1224|Proteobacteria,2VK5Z@28216|Betaproteobacteria,1K0NP@119060|Burkholderiaceae 28216|Betaproteobacteria IQ Short-chain dehydrogenase reductase sdr - - - - - - - - - - - - adh_short_C2 k59_1168368_3 113395.AXAI01000003_gene5747 1.58e-32 119.0 COG3631@1|root,COG3631@2|Bacteria,1P5A2@1224|Proteobacteria,2TV5B@28211|Alphaproteobacteria,3JR2U@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S SnoaL-like domain MA20_24415 - - - - - - - - - - - SnoaL_2 k59_955146_1 292415.Tbd_1668 5.55e-75 243.0 COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2VH5T@28216|Betaproteobacteria 28216|Betaproteobacteria P Belongs to the ABC transporter superfamily dppF - - ko:K02031,ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_955146_2 95619.PM1_0210850 5.29e-21 95.9 COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,1RMFZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) mltD - - ko:K08307 - - - - ko00000,ko01000,ko01011 - - - LysM,MLTD_N,SLT k59_1123280_1 994479.GL877880_gene4013 2.34e-12 68.6 COG2267@1|root,COG2267@2|Bacteria,2I3KS@201174|Actinobacteria,4E24P@85010|Pseudonocardiales 201174|Actinobacteria I Alpha/beta hydrolase family - - 3.1.1.24 ko:K01055 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00568 R02991 RC00825 ko00000,ko00001,ko00002,ko01000 - - - Abhydrolase_1 k59_699568_1 395961.Cyan7425_4133 1.25e-41 157.0 COG0474@1|root,COG0474@2|Bacteria,1G0JX@1117|Cyanobacteria,3KGUQ@43988|Cyanothece 1117|Cyanobacteria P TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.2,3.6.3.8 ko:K01531,ko:K01537,ko:K12952 - - - - ko00000,ko01000 3.A.3.2,3.A.3.23,3.A.3.4 - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase k59_143252_1 977880.RALTA_A2160 3.25e-64 216.0 COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,2VHBQ@28216|Betaproteobacteria,1K0F8@119060|Burkholderiaceae 28216|Betaproteobacteria L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parE - - ko:K02622 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_361954_1 436308.Nmar_1577 1.66e-102 311.0 COG0459@1|root,arCOG01257@2157|Archaea,41T11@651137|Thaumarchaeota 651137|Thaumarchaeota O TCP-1/cpn60 chaperonin family - - - ko:K22447 - - - - ko00000,ko03110 - - - Cpn60_TCP1 k59_955186_1 316067.Geob_3695 8.86e-26 100.0 COG0835@1|root,COG0835@2|Bacteria,1RD1W@1224|Proteobacteria,42T5Y@68525|delta/epsilon subdivisions,2WPM8@28221|Deltaproteobacteria,43VJ6@69541|Desulfuromonadales 28221|Deltaproteobacteria NT Two component signalling adaptor domain cheW36H - - ko:K03408 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CheW k59_955186_2 269799.Gmet_2423 4.68e-06 52.8 COG0840@1|root,COG1511@1|root,COG0840@2|Bacteria,COG1511@2|Bacteria,1MU9B@1224|Proteobacteria,42KZR@68525|delta/epsilon subdivisions,2WJ2T@28221|Deltaproteobacteria,43STW@69541|Desulfuromonadales 28221|Deltaproteobacteria NT histidine kinase HAMP region domain protein mcp34H-3 - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,CZB,HAMP,MCPsignal,dCache_1 k59_1253819_1 1163617.SCD_n01777 6.44e-64 204.0 COG1562@1|root,COG1562@2|Bacteria,1MX4W@1224|Proteobacteria,2VJ13@28216|Betaproteobacteria 28216|Betaproteobacteria I phytoene synthase hpnD - 2.5.1.32,2.5.1.99 ko:K02291 ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110 M00097 R02065,R04218,R07270,R10177 RC00362,RC01101,RC02869 ko00000,ko00001,ko00002,ko01000,ko01006 - - - SQS_PSY k59_824916_2 1121033.AUCF01000003_gene3328 4.72e-29 111.0 2E8MG@1|root,332YX@2|Bacteria,1NA87@1224|Proteobacteria,2UGW0@28211|Alphaproteobacteria,2JU7Z@204441|Rhodospirillales 204441|Rhodospirillales - - - - - - - - - - - - - - - k59_143285_1 1281779.H009_21606 1.17e-64 209.0 COG2132@1|root,COG2132@2|Bacteria,1MV74@1224|Proteobacteria,2U1BK@28211|Alphaproteobacteria,4BADC@82115|Rhizobiaceae 28211|Alphaproteobacteria Q Nitrite reductase nirK - 1.7.2.1 ko:K00368 ko00910,ko01120,map00910,map01120 M00529 R00783,R00785 RC00086 ko00000,ko00001,ko00002,ko01000 - - - Cu-oxidase,Cu-oxidase_3 k59_320107_2 1219049.SP5_005_00880 3.46e-45 150.0 COG0432@1|root,COG0432@2|Bacteria,1RH13@1224|Proteobacteria,2U945@28211|Alphaproteobacteria,2K4HM@204457|Sphingomonadales 204457|Sphingomonadales S Uncharacterised protein family UPF0047 - - - - - - - - - - - - UPF0047 k59_997778_1 1082933.MEA186_30901 1.56e-54 193.0 COG1572@1|root,COG2931@1|root,COG3210@1|root,COG4070@1|root,COG1572@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4070@2|Bacteria,1MU7T@1224|Proteobacteria 1224|Proteobacteria Q COG2931, RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - Autotransporter,Cadherin-like,Calx-beta,DUF4347,He_PIG k59_401008_1 317655.Sala_1716 7.8e-33 124.0 COG0604@1|root,COG0604@2|Bacteria,1MWRK@1224|Proteobacteria,2TQMF@28211|Alphaproteobacteria,2JZUR@204457|Sphingomonadales 204457|Sphingomonadales C COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases - - - - - - - - - - - - ADH_N,ADH_zinc_N,ADH_zinc_N_2 k59_100948_2 1000565.METUNv1_00035 1.69e-41 150.0 COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,2VING@28216|Betaproteobacteria,2KU9B@206389|Rhodocyclales 206389|Rhodocyclales D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase tig GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K03545 - - - - ko00000 - - - FKBP_C,Trigger_C,Trigger_N k59_1123405_1 1380391.JIAS01000011_gene4750 9.64e-83 256.0 COG4977@1|root,COG4977@2|Bacteria,1MUDK@1224|Proteobacteria,2TS7I@28211|Alphaproteobacteria,2JPZ7@204441|Rhodospirillales 204441|Rhodospirillales K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - DJ-1_PfpI,HTH_18 k59_656544_1 1123279.ATUS01000001_gene925 5.05e-69 219.0 COG2908@1|root,COG2908@2|Bacteria,1N3U7@1224|Proteobacteria,1RP1X@1236|Gammaproteobacteria,1J5TJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxH GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008758,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019637,GO:0019897,GO:0019898,GO:0030145,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044459,GO:0044464,GO:0046467,GO:0046493,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 3.6.1.54 ko:K03269 ko00540,ko01100,map00540,map01100 M00060 R04549 RC00002 ko00000,ko00001,ko00002,ko01000,ko01005 - - iE2348C_1286.E2348C_0457 Metallophos,Metallophos_2 k59_656544_2 1121939.L861_19010 7.45e-55 183.0 COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,1RMCV@1236|Gammaproteobacteria,1XHB8@135619|Oceanospirillales 135619|Oceanospirillales E Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide metZ - - ko:K10764 ko00270,ko00920,ko01100,map00270,map00920,map01100 - R01288 RC00020,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP k59_912896_1 1231185.BAMP01000031_gene724 5.93e-25 107.0 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2TUKZ@28211|Alphaproteobacteria,43JAQ@69277|Phyllobacteriaceae 28211|Alphaproteobacteria J Belongs to the amidase family - - 3.5.1.4,6.3.5.6,6.3.5.7 ko:K01426,ko:K02433 ko00330,ko00360,ko00380,ko00627,ko00643,ko00970,ko01100,ko01120,map00330,map00360,map00380,map00627,map00643,map00970,map01100,map01120 - R02540,R03096,R03180,R03905,R03909,R04212,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_101000_1 1121918.ARWE01000001_gene1755 1.33e-38 137.0 COG1999@1|root,COG1999@2|Bacteria,1N19Q@1224|Proteobacteria,42XV1@68525|delta/epsilon subdivisions,2WSUD@28221|Deltaproteobacteria 28221|Deltaproteobacteria S SCO1 SenC - - - ko:K07152 - - - - ko00000,ko03029 - - - SCO1-SenC k59_271499_1 1454004.AW11_03673 3.24e-54 181.0 COG1651@1|root,COG1651@2|Bacteria,1RD39@1224|Proteobacteria,2VIHV@28216|Betaproteobacteria,1KQRT@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria O Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process dsbC - 5.3.4.1 ko:K03981 - - - - ko00000,ko01000,ko02044,ko03110 3.A.7.11.1 - - DsbC_N,Thioredoxin_2 k59_271514_1 1247726.MIM_c08590 1.43e-22 101.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VHAT@28216|Betaproteobacteria,3T1C9@506|Alcaligenaceae 28216|Betaproteobacteria IQ Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - 6.2.1.3 ko:K00666,ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_1211307_1 1000565.METUNv1_02684 5.26e-66 216.0 COG1721@1|root,COG1721@2|Bacteria,1R3QD@1224|Proteobacteria,2VN9P@28216|Betaproteobacteria,2KW8Q@206389|Rhodocyclales 206389|Rhodocyclales S conserved protein (some members contain a von Willebrand factor type A (vWA) domain) - - - - - - - - - - - - DUF58 k59_825072_1 290397.Adeh_3010 4.31e-128 374.0 COG0604@1|root,COG0604@2|Bacteria,1MWBD@1224|Proteobacteria,42PQH@68525|delta/epsilon subdivisions,2WM5W@28221|Deltaproteobacteria,2YWUY@29|Myxococcales 28221|Deltaproteobacteria C Zinc-binding dehydrogenase - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N,ADH_zinc_N_2 k59_362253_1 76114.ebA977 8.88e-102 323.0 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,2VH5B@28216|Betaproteobacteria,2KVC4@206389|Rhodocyclales 206389|Rhodocyclales H Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell glnE - 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_699826_1 1038859.AXAU01000026_gene2328 3.6e-77 241.0 COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,2TR0J@28211|Alphaproteobacteria,3JRF7@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria EP Oligopeptide/dipeptide transporter, C-terminal region - - - ko:K15583 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - ABC_tran,oligo_HPY k59_699826_2 400682.PAC_15710332 1.94e-33 129.0 COG1132@1|root,KOG0055@2759|Eukaryota,39YRK@33154|Opisthokonta,3BN4Z@33208|Metazoa 33208|Metazoa Q atp-binding protein - - - - - - - - - - - - ABC_tran,oligo_HPY k59_320312_1 1394178.AWOO02000029_gene4605 5.68e-59 196.0 COG3844@1|root,COG3844@2|Bacteria,2GMJQ@201174|Actinobacteria,4EH57@85012|Streptosporangiales 201174|Actinobacteria E Aminotransferase class-V kynU - 3.7.1.3 ko:K01556 ko00380,ko01100,map00380,map01100 M00038 R00987,R02668,R03936 RC00284,RC00415 ko00000,ko00001,ko00002,ko01000 - - - Aminotran_5 k59_230389_2 1123487.KB892868_gene1229 4.77e-55 193.0 COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,2VHY4@28216|Betaproteobacteria,2KUHK@206389|Rhodocyclales 206389|Rhodocyclales U Type 4 fimbrial biogenesis protein pilQ - - ko:K02666 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - AMIN,STN,Secretin,Secretin_N k59_320348_1 1123279.ATUS01000001_gene1081 1.45e-14 75.9 COG2207@1|root,COG2207@2|Bacteria,1MX23@1224|Proteobacteria,1RPJC@1236|Gammaproteobacteria,1JBVE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - Arabinose_bd,HTH_18 k59_320348_2 1231190.NA8A_11695 2e-12 67.0 COG0786@1|root,COG0786@2|Bacteria,1MVBC@1224|Proteobacteria,2U12R@28211|Alphaproteobacteria,43H8Z@69277|Phyllobacteriaceae 28211|Alphaproteobacteria E Sodium/glutamate symporter gltS - - ko:K03312 - - - - ko00000,ko02000 2.A.27 - - Glt_symporter k59_1211379_1 1211115.ALIQ01000206_gene4728 4.85e-115 346.0 COG0129@1|root,COG0129@2|Bacteria,1MV4I@1224|Proteobacteria,2TQRW@28211|Alphaproteobacteria,3NC3N@45404|Beijerinckiaceae 28211|Alphaproteobacteria EG Dehydratase family ilvD2 - 4.2.1.25 ko:K13875 ko00053,ko01100,map00053,map01100 - R02522 RC00543 ko00000,ko00001,ko01000 - - - ILVD_EDD k59_444053_1 596151.DesfrDRAFT_0628 1.44e-31 120.0 COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,42MCE@68525|delta/epsilon subdivisions,2WIYP@28221|Deltaproteobacteria,2MGAZ@213115|Desulfovibrionales 28221|Deltaproteobacteria M PFAM Glycosyl transferase family 2 - - 2.4.2.53 ko:K10012 ko00520,ko01503,map00520,map01503 M00721,M00761 R07661 RC00005,RC02954 ko00000,ko00001,ko00002,ko01000,ko01005,ko02000 4.D.2.1.8 GT2 - Glycos_transf_2 k59_788610_1 644801.Psest_0531 8.42e-58 192.0 COG1702@1|root,COG1702@2|Bacteria,1MVDV@1224|Proteobacteria,1RP2Y@1236|Gammaproteobacteria,1Z0Z0@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria T phosphate starvation-inducible protein PhoH ybeZ GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K06217 - - - - ko00000 - - - PhoH k59_1045185_1 1297569.MESS2_1020028 2.28e-72 233.0 COG1861@1|root,COG1861@2|Bacteria,1QU5J@1224|Proteobacteria,2U0ZH@28211|Alphaproteobacteria 28211|Alphaproteobacteria L DDE (Asp,Asp,Glu) domain - - - - - - - - - - - - DDE_Tnp_1_4 k59_188267_1 485913.Krac_5632 1.3e-21 94.7 COG1028@1|root,COG1028@2|Bacteria,2G660@200795|Chloroflexi 200795|Chloroflexi IQ COGs COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase) - - - - - - - - - - - - adh_short k59_188267_2 631362.Thi970DRAFT_00017 3.02e-08 52.8 COG2343@1|root,COG2343@2|Bacteria,1RJ3M@1224|Proteobacteria,1RVCY@1236|Gammaproteobacteria,1WY8R@135613|Chromatiales 135613|Chromatiales S Domain of unknown function (DUF427) - - - - - - - - - - - - NTP_transf_9 k59_1128470_1 396588.Tgr7_2271 2.77e-98 301.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMIW@1236|Gammaproteobacteria,1WW9V@135613|Chromatiales 135613|Chromatiales J TIGRFAM ribonuclease, Rne Rng family - - - ko:K08301 - - - - ko00000,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_1217055_1 1191523.MROS_2077 6.5e-74 236.0 COG2211@1|root,COG2211@2|Bacteria 2|Bacteria G Major facilitator Superfamily - - - ko:K03292,ko:K16248 - - - - ko00000,ko02000 2.A.2 - - MFS_2,MFS_3 k59_148785_1 1500897.JQNA01000002_gene1586 1.27e-30 124.0 COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,2VHHA@28216|Betaproteobacteria,1K174@119060|Burkholderiaceae 28216|Betaproteobacteria L May be involved in recombinational repair of damaged DNA recN - - ko:K03631 - - - - ko00000,ko03400 - - - SMC_N k59_492278_1 748280.NH8B_1920 1.34e-92 296.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2VJIV@28216|Betaproteobacteria,2KPDT@206351|Neisseriales 206351|Neisseriales F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides nrdA - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN k59_449703_1 414684.RC1_1075 8.35e-43 160.0 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria,2JQ9H@204441|Rhodospirillales 204441|Rhodospirillales C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - 1.2.5.3 ko:K03520 - - R11168 RC02800 ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_794813_3 87626.PTD2_03031 2.63e-22 89.7 COG3791@1|root,COG3791@2|Bacteria,1RHWZ@1224|Proteobacteria,1S4HQ@1236|Gammaproteobacteria,2Q2VN@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria S Glutathione-dependent formaldehyde-activating enzyme - - - - - - - - - - - - GFA k59_449745_1 1454004.AW11_00015 2.94e-38 135.0 COG0357@1|root,COG0357@2|Bacteria,1MY0K@1224|Proteobacteria,2VR3B@28216|Betaproteobacteria,1KQ1N@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria J Specifically methylates the N7 position of guanine in position 527 of 16S rRNA rsmG - 2.1.1.170 ko:K03501 - - - - ko00000,ko01000,ko03009,ko03036 - - - GidB k59_148856_1 570967.JMLV01000004_gene587 2.32e-24 99.4 COG0596@1|root,COG0596@2|Bacteria,1NUT9@1224|Proteobacteria,2TVMS@28211|Alphaproteobacteria,2JVBP@204441|Rhodospirillales 204441|Rhodospirillales I Alpha/beta hydrolase family - - - - - - - - - - - - Abhydrolase_1 k59_148856_2 999541.bgla_2g13850 3.43e-16 80.5 COG2271@1|root,COG2271@2|Bacteria,1QTYR@1224|Proteobacteria,2W0XP@28216|Betaproteobacteria,1KGJK@119060|Burkholderiaceae 28216|Betaproteobacteria G Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_325560_1 928210.CALU01000007_gene522 7.09e-41 153.0 COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,2TQJT@28211|Alphaproteobacteria,48TV6@772|Bartonellaceae 28211|Alphaproteobacteria C Malic enzyme, NAD binding domain dme GO:0003674,GO:0003824,GO:0004470,GO:0004473,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0030145,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0055114 1.1.1.40 ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200 M00169,M00172 R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - - Malic_M,PTA_PTB,malic k59_1003665_1 402881.Plav_3485 1.61e-79 251.0 COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,2TS6F@28211|Alphaproteobacteria,1JNAS@119043|Rhodobiaceae 28211|Alphaproteobacteria O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA - - ko:K04485 - - - - ko00000,ko03400 - - - AAA_25,ATPase,ChlI k59_705621_1 85643.Tmz1t_3709 2.69e-70 236.0 COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,2VJG2@28216|Betaproteobacteria,2KU82@206389|Rhodocyclales 206389|Rhodocyclales C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_748205_1 85643.Tmz1t_3382 1.83e-99 298.0 COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,2VI9W@28216|Betaproteobacteria,2KUAU@206389|Rhodocyclales 206389|Rhodocyclales O HflC and HflK could regulate a protease hflC - - ko:K04087 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7 k59_1217219_2 42565.FP66_05940 3.78e-19 87.0 COG1286@1|root,COG1286@2|Bacteria,1NF4G@1224|Proteobacteria,1RQ58@1236|Gammaproteobacteria,1XKNI@135619|Oceanospirillales 135619|Oceanospirillales S colicin V production cvpA - - ko:K03558 - - - - ko00000 - - - Colicin_V k59_1217219_3 365044.Pnap_1092 7.92e-36 133.0 COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,2VJM1@28216|Betaproteobacteria,4AASC@80864|Comamonadaceae 28216|Betaproteobacteria F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF - 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase_6,GATase_7,Pribosyltran k59_492416_1 414684.RC1_0412 1e-46 170.0 COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2TRC2@28211|Alphaproteobacteria,2JPYX@204441|Rhodospirillales 204441|Rhodospirillales I COG4770 Acetyl propionyl-CoA carboxylase, alpha subunit - - 6.4.1.3 ko:K01965 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R01859 RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_1217228_1 395019.Bmul_0305 8.54e-96 311.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,2VHUY@28216|Betaproteobacteria,1K0VQ@119060|Burkholderiaceae 28216|Betaproteobacteria E glutamate synthase gltB - 1.4.1.13,1.4.1.14,1.4.7.1 ko:K00265,ko:K00284 ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 - R00021,R00093,R00114,R00248,R10086 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_245345_2 882378.RBRH_03084 5.97e-47 165.0 COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,2VK4X@28216|Betaproteobacteria,1K3SV@119060|Burkholderiaceae 28216|Betaproteobacteria K Transcriptional regulator, LysR family - - - - - - - - - - - - HTH_1,LysR_substrate k59_583505_1 292459.STH1574 6.79e-32 126.0 COG3185@1|root,COG3185@2|Bacteria,1TQT2@1239|Firmicutes,249CY@186801|Clostridia 186801|Clostridia E Acyclic terpene utilisation family protein AtuA - - - - - - - - - - - - AtuA k59_78824_1 1218084.BBJK01000057_gene4372 5.54e-30 122.0 COG0741@1|root,COG0741@2|Bacteria,1RAP3@1224|Proteobacteria,2VQXG@28216|Betaproteobacteria,1K1Z2@119060|Burkholderiaceae 28216|Betaproteobacteria M PFAM Lytic transglycosylase catalytic - - - - - - - - - - - - SLT k59_1268048_1 358220.C380_10590 2.68e-39 144.0 COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VHK8@28216|Betaproteobacteria,4AB79@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM conserved - - - - - - - - - - - - TctC k59_880371_1 1417296.U879_00395 4.88e-24 104.0 COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,2TUAD@28211|Alphaproteobacteria 28211|Alphaproteobacteria S COG1520 FOG WD40-like repeat bamB - - ko:K17713 - - - - ko00000,ko02000 1.B.33.1 - - PQQ_2,PQQ_3 k59_333543_1 550540.Fbal_2774 1.17e-35 133.0 COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,1RNTY@1236|Gammaproteobacteria 1236|Gammaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secF GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - ko:K03074 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_458148_1 204669.Acid345_0642 5.54e-15 73.2 COG1028@1|root,COG1028@2|Bacteria,3Y2YB@57723|Acidobacteria,2JII9@204432|Acidobacteriia 204432|Acidobacteriia IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short_C2 k59_458148_2 395019.Bmul_2455 1.42e-73 229.0 COG0179@1|root,COG0179@2|Bacteria,1MUPF@1224|Proteobacteria,2VI5Z@28216|Betaproteobacteria,1K1Y5@119060|Burkholderiaceae 28216|Betaproteobacteria Q PFAM fumarylacetoacetate (FAA) hydrolase - - - ko:K18336 ko00051,ko01120,map00051,map01120 - R10691 RC00326,RC03236 ko00000,ko00001,ko01000 - - - FAA_hydrolase k59_114872_1 667014.Thein_0593 6.55e-25 103.0 COG0438@1|root,COG0438@2|Bacteria,2GHMH@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - - k59_114872_2 706587.Desti_1352 2.56e-13 70.5 COG0438@1|root,COG0438@2|Bacteria,1MYTB@1224|Proteobacteria,42MCA@68525|delta/epsilon subdivisions,2WJVX@28221|Deltaproteobacteria,2MQT9@213462|Syntrophobacterales 28221|Deltaproteobacteria M PFAM Glycosyl transferases group 1 - - 2.4.1.245 ko:K13057 ko00500,ko01100,map00500,map01100 - R08946,R10525,R11306 RC00005,RC00049,RC02748 ko00000,ko00001,ko01000 - GT4 - Glycos_transf_1 k59_78888_1 1173025.GEI7407_0458 0.000659 41.6 COG1972@1|root,COG1972@2|Bacteria,1G3CA@1117|Cyanobacteria,1H7FT@1150|Oscillatoriales 1117|Cyanobacteria F PFAM Na dependent nucleoside transporter - - - ko:K03317 - - - - ko00000 2.A.41 - - Gate,Nucleos_tra2_C,Nucleos_tra2_N k59_78888_2 631362.Thi970DRAFT_04180 2.67e-69 218.0 COG0284@1|root,COG0284@2|Bacteria,1MW2C@1224|Proteobacteria,1RNJR@1236|Gammaproteobacteria,1WW0C@135613|Chromatiales 135613|Chromatiales F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) pyrF - 4.1.1.23 ko:K01591 ko00240,ko01100,map00240,map01100 M00051 R00965 RC00409 ko00000,ko00001,ko00002,ko01000 - - - OMPdecase k59_756363_2 247639.MGP2080_05407 6.3e-46 160.0 COG1442@1|root,COG1442@2|Bacteria,1QH4S@1224|Proteobacteria 1224|Proteobacteria M glycosyl transferase family 8 - - - - - - - - - - - - Glyco_transf_8 k59_543286_1 979556.MTES_2359 2e-15 75.5 COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,4FKGH@85023|Microbacteriaceae 201174|Actinobacteria E Belongs to the ABC transporter superfamily - - - ko:K10112 ko02010,map02010 M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1 - - ABC_tran,TOBE_2 k59_543286_2 1054213.HMPREF9946_04581 1.16e-63 202.0 COG0395@1|root,COG0395@2|Bacteria,1PG6Q@1224|Proteobacteria,2U1HZ@28211|Alphaproteobacteria,2JW7Y@204441|Rhodospirillales 204441|Rhodospirillales G Binding-protein-dependent transport system inner membrane component - - - - - - - - - - - - BPD_transp_1 k59_157175_1 1245469.S58_12040 2.53e-69 220.0 COG4608@1|root,COG4608@2|Bacteria,1NU4K@1224|Proteobacteria,2TQTV@28211|Alphaproteobacteria,3JRYC@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Belongs to the ABC transporter superfamily MA20_20675 - - ko:K10823 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - ABC_tran,oligo_HPY k59_34012_1 882083.SacmaDRAFT_1909 4.56e-49 169.0 COG2141@1|root,COG2141@2|Bacteria,2GJRF@201174|Actinobacteria,4DYVJ@85010|Pseudonocardiales 201174|Actinobacteria C Luciferase-like monooxygenase - - 1.5.98.2 ko:K00320 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00567 R04464 RC01607 ko00000,ko00001,ko00002,ko01000 - - - Bac_luciferase k59_1182813_1 438753.AZC_1935 1.33e-53 176.0 COG0846@1|root,COG0846@2|Bacteria,1MUK1@1224|Proteobacteria,2TV1Q@28211|Alphaproteobacteria,3EZ5P@335928|Xanthobacteraceae 28211|Alphaproteobacteria K Sir2 family MA20_30275 - - ko:K12410 - - - - ko00000,ko01000 - - - SIR2 k59_927177_1 1038858.AXBA01000001_gene3498 4.91e-80 246.0 COG0388@1|root,COG0388@2|Bacteria,1MXG5@1224|Proteobacteria,2TVCS@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - 3.5.1.77 ko:K01459 - - - - ko00000,ko01000 - - - CN_hydrolase k59_927177_2 1380394.JADL01000012_gene1070 4.67e-05 44.7 COG0028@1|root,COG0028@2|Bacteria,1R6QP@1224|Proteobacteria,2TUEF@28211|Alphaproteobacteria,2JVP8@204441|Rhodospirillales 204441|Rhodospirillales EH Thiamine pyrophosphate enzyme, N-terminal TPP binding domain - - 4.1.1.82 ko:K09459 ko00440,ko01100,ko01120,ko01130,map00440,map01100,map01120,map01130 - R04053 RC00506 ko00000,ko00001,ko01000 - - - TPP_enzyme_C,TPP_enzyme_N k59_583642_1 1255043.TVNIR_2714 3.45e-17 79.0 COG2197@1|root,COG2197@2|Bacteria,1NQH7@1224|Proteobacteria,1RNXI@1236|Gammaproteobacteria,1WWCR@135613|Chromatiales 135613|Chromatiales K response regulator receiver - - - ko:K07684 ko02020,map02020 M00471 - - ko00000,ko00001,ko00002,ko02022 - - - GerE,Response_reg k59_583642_2 864051.BurJ1DRAFT_3342 8.64e-67 221.0 COG1018@1|root,COG1018@2|Bacteria,1REP4@1224|Proteobacteria,2VPWB@28216|Betaproteobacteria 28216|Betaproteobacteria C 2Fe-2S iron-sulfur cluster binding domain - - 1.17.1.1 ko:K00523 ko00520,map00520 - R03391,R03392 RC00230 ko00000,ko00001,ko01000 - - - FAD_binding_6,Fer2 k59_1103999_1 886293.Sinac_2761 8.86e-66 225.0 COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2IYTQ@203682|Planctomycetes 203682|Planctomycetes KLT PFAM Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase,TPR_11,TPR_16 k59_1061766_1 1429916.X566_14915 3.26e-66 218.0 COG2072@1|root,COG2072@2|Bacteria,1MUQH@1224|Proteobacteria,2TRG4@28211|Alphaproteobacteria,3JRSQ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P Flavin-binding monooxygenase-like - - 1.14.13.22 ko:K03379 ko00930,ko01120,ko01220,map00930,map01120,map01220 - R02231,R06622 RC00662,RC01550 ko00000,ko00001,ko01000 - - - FMO-like,Pyr_redox_3 k59_202258_1 395964.KE386496_gene2969 2.29e-124 369.0 COG2759@1|root,COG2759@2|Bacteria,1MUR8@1224|Proteobacteria,2TRMM@28211|Alphaproteobacteria,3NASQ@45404|Beijerinckiaceae 28211|Alphaproteobacteria F formate-tetrahydrofolate ligase activity fhs - 6.3.4.3 ko:K01938 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R00943 RC00026,RC00111 ko00000,ko00001,ko00002,ko01000 - - - FTHFS k59_1182908_1 1121914.AUDW01000003_gene966 1.34e-15 81.3 COG0531@1|root,COG0531@2|Bacteria,1TQ48@1239|Firmicutes,4HBGT@91061|Bacilli,3WG19@539002|Bacillales incertae sedis 91061|Bacilli E Amino acid permease frlA - - ko:K03294 - - - - ko00000 2.A.3.2 - - AA_permease_2 k59_416281_1 1380394.JADL01000004_gene5735 9.97e-18 79.0 COG1832@1|root,COG1832@2|Bacteria,1N03D@1224|Proteobacteria,2TUIY@28211|Alphaproteobacteria,2JRXU@204441|Rhodospirillales 204441|Rhodospirillales S CoA binding domain yccU - - ko:K06929 - - - - ko00000 - - - CoA_binding_2 k59_416281_2 1238182.C882_1824 2.83e-98 296.0 COG1024@1|root,COG1024@2|Bacteria,1MUJ7@1224|Proteobacteria,2TTMB@28211|Alphaproteobacteria,2JQEF@204441|Rhodospirillales 204441|Rhodospirillales I Enoyl-CoA hydratase - - - - - - - - - - - - ECH_1 k59_500844_1 983917.RGE_01680 6.43e-32 115.0 COG1186@1|root,COG1186@2|Bacteria,1RH75@1224|Proteobacteria,2VSE7@28216|Betaproteobacteria,1KMBI@119065|unclassified Burkholderiales 28216|Betaproteobacteria J RF-1 domain yaeJ - - ko:K15034 - - - - ko00000,ko03012 - - - RF-1 k59_713963_1 472759.Nhal_1635 9.46e-71 238.0 COG0398@1|root,COG1502@1|root,COG0398@2|Bacteria,COG1502@2|Bacteria,1MV8I@1224|Proteobacteria,1RSB6@1236|Gammaproteobacteria,1WXPA@135613|Chromatiales 135613|Chromatiales I PFAM SNARE associated Golgi protein - - - - - - - - - - - - PLDc,PLDc_2,SNARE_assoc k59_458308_3 1218074.BAXZ01000011_gene2731 5.02e-07 52.0 2E95F@1|root,333E6@2|Bacteria,1N8N7@1224|Proteobacteria,2VWBC@28216|Betaproteobacteria,1K70X@119060|Burkholderiaceae 28216|Betaproteobacteria S Protein of unknown function (DUF3619) - - - - - - - - - - - - DUF3619 k59_583728_1 1328313.DS2_18173 1.31e-05 47.8 COG3119@1|root,COG3119@2|Bacteria,1RAY6@1224|Proteobacteria,1RY4U@1236|Gammaproteobacteria,465PX@72275|Alteromonadaceae 1236|Gammaproteobacteria P Sulfatase - - - - - - - - - - - - Sulfatase k59_583728_2 1123023.JIAI01000001_gene6533 2.01e-51 173.0 COG3384@1|root,COG3384@2|Bacteria,2GJDG@201174|Actinobacteria 201174|Actinobacteria S PFAM Extradiol ring-cleavage dioxygenase, class III enzyme, subunit B - - - - - - - - - - - - LigB k59_79044_1 1000565.METUNv1_02091 6.59e-56 180.0 COG3175@1|root,COG3175@2|Bacteria,1RDTU@1224|Proteobacteria,2VHRQ@28216|Betaproteobacteria,2KWGM@206389|Rhodocyclales 206389|Rhodocyclales O oxidase assembly - - - ko:K02258 ko00190,ko01100,ko04714,map00190,map01100,map04714 M00154 - - ko00000,ko00001,ko00002,ko03029 3.D.4.8 - - CtaG_Cox11 k59_1061868_1 1125973.JNLC01000010_gene1128 9.04e-58 194.0 COG0402@1|root,COG0402@2|Bacteria,1MUFE@1224|Proteobacteria,2TR3A@28211|Alphaproteobacteria,3JRSG@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria F Amidohydrolase family hutF - 3.5.3.13 ko:K05603 ko00340,map00340 - R02286 RC00682 ko00000,ko00001,ko01000 - - - Amidohydro_1 k59_202338_1 78398.KS43_06265 7.65e-44 165.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,1RP0K@1236|Gammaproteobacteria,1MPV4@122277|Pectobacterium 1236|Gammaproteobacteria L DNA polymerase III alpha subunit dnaE GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032991,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0046483,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_382971_2 292415.Tbd_0579 1.62e-16 75.1 COG2927@1|root,COG2927@2|Bacteria,1MZ3V@1224|Proteobacteria,2VTYC@28216|Betaproteobacteria 28216|Betaproteobacteria L dna polymerase III (Chi subunit) holC - 2.7.7.7 ko:K02339 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_chi k59_422354_1 296591.Bpro_3388 1e-92 281.0 COG0620@1|root,COG0620@2|Bacteria,1MV2Z@1224|Proteobacteria,2VKXM@28216|Betaproteobacteria,4AAFX@80864|Comamonadaceae 28216|Betaproteobacteria E Methionine synthase - - 2.1.1.14 ko:K00549 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 M00017 R04405,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - Meth_synt_2 k59_1189034_1 1123023.JIAI01000002_gene5634 4.17e-16 77.0 COG1853@1|root,COG1853@2|Bacteria,2IK4U@201174|Actinobacteria 201174|Actinobacteria S Flavin reductase like domain - - 1.5.1.36 ko:K00484,ko:K09024 ko00240,ko00350,ko00740,ko01100,ko01120,ko01220,map00240,map00350,map00740,map01100,map01120,map01220 - R02698,R03299,R05705,R09748,R09750,R09936 RC00046,RC00126,RC02732 ko00000,ko00001,ko01000 - - - Flavin_Reduct k59_1189034_2 596154.Alide2_3809 4.3e-44 151.0 COG1733@1|root,COG1733@2|Bacteria,1NEKW@1224|Proteobacteria,2WEVZ@28216|Betaproteobacteria,4AJJI@80864|Comamonadaceae 28216|Betaproteobacteria K HxlR-like helix-turn-helix - - - - - - - - - - - - HxlR k59_291495_1 497321.C664_02740 2.3e-135 401.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2VHEV@28216|Betaproteobacteria,2KU76@206389|Rhodocyclales 206389|Rhodocyclales O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_291516_1 395493.BegalDRAFT_3504 5.28e-13 74.7 COG3307@1|root,COG3307@2|Bacteria,1R495@1224|Proteobacteria,1SF8U@1236|Gammaproteobacteria,463SU@72273|Thiotrichales 72273|Thiotrichales M O-antigen ligase like membrane protein - - - - - - - - - - - - Wzy_C k59_464456_2 159087.Daro_2938 2.23e-31 125.0 28MTI@1|root,2ZB1Q@2|Bacteria,1R894@1224|Proteobacteria,2VMZB@28216|Betaproteobacteria,2KVD1@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_464478_1 1304275.C41B8_18892 1.66e-26 105.0 COG0726@1|root,COG0726@2|Bacteria,1MV3V@1224|Proteobacteria,1RPKM@1236|Gammaproteobacteria 1236|Gammaproteobacteria G deacetylase puuE - 3.5.1.104,3.5.1.41,3.5.2.5 ko:K01452,ko:K16842,ko:K22278 ko00230,ko00520,ko01100,ko01120,map00230,map00520,map01100,map01120 M00546 R02333,R02425 RC00166,RC00300,RC00680 ko00000,ko00001,ko00002,ko01000 - - - Polysacc_deac_1 k59_1316913_1 414684.RC1_1541 1.06e-75 238.0 COG0349@1|root,COG0349@2|Bacteria,1MURV@1224|Proteobacteria,2TSQM@28211|Alphaproteobacteria,2JP8M@204441|Rhodospirillales 204441|Rhodospirillales J Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides rnd - 3.1.13.5 ko:K03684 - - - - ko00000,ko01000,ko03016 - - - DNA_pol_A_exo1,HRDC k59_507029_1 1122201.AUAZ01000002_gene952 2.24e-06 54.3 COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,1RMFZ@1236|Gammaproteobacteria,464A9@72275|Alteromonadaceae 1236|Gammaproteobacteria M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) mltD GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008150,GO:0008932,GO:0008933,GO:0009893,GO:0016020,GO:0016740,GO:0016757,GO:0019222,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043085,GO:0044093,GO:0044464,GO:0048518,GO:0050789,GO:0050790,GO:0051341,GO:0051353,GO:0061783,GO:0065007,GO:0065009 - ko:K08307 - - - - ko00000,ko01000,ko01011 - - - LysM,SLT k59_464490_1 94624.Bpet0102 2.22e-87 266.0 COG1173@1|root,COG1173@2|Bacteria,1MUG0@1224|Proteobacteria,2VIN2@28216|Betaproteobacteria,3T5VQ@506|Alcaligenaceae 28216|Betaproteobacteria P ABC-type dipeptide oligopeptide nickel transport systems, permease components dppC_1 - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1,OppC_N k59_464490_2 1089552.KI911559_gene3264 1.55e-13 69.7 COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TR3F@28211|Alphaproteobacteria,2JQU0@204441|Rhodospirillales 204441|Rhodospirillales EP Binding-protein-dependent transport system inner membrane component - - - - - - - - - - - - BPD_transp_1 k59_885877_1 570952.ATVH01000013_gene2657 1.28e-35 134.0 COG3572@1|root,COG3572@2|Bacteria,1MU47@1224|Proteobacteria,2TRPT@28211|Alphaproteobacteria,2JPAV@204441|Rhodospirillales 204441|Rhodospirillales H glutamate--cysteine ligase gshA - 6.3.2.2 ko:K01919 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00894,R10993 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - GCS2 k59_549572_1 926559.JoomaDRAFT_0598 4.88e-32 119.0 COG3637@1|root,COG3637@2|Bacteria,4PPA3@976|Bacteroidetes,1I0PG@117743|Flavobacteriia 976|Bacteroidetes M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - - - - - - - - - - - k59_549572_2 565045.NOR51B_448 4.86e-56 190.0 COG1524@1|root,COG1524@2|Bacteria,1R5V5@1224|Proteobacteria,1S06C@1236|Gammaproteobacteria,1J9AQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S proteins of the AP superfamily pafA - - - - - - - - - - - Phosphodiest k59_40480_1 522306.CAP2UW1_2651 4.64e-48 162.0 COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,2VIX7@28216|Betaproteobacteria 28216|Betaproteobacteria K Transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate k59_40480_3 1158756.AQXQ01000012_gene1995 2.18e-20 82.0 2E4KB@1|root,32ZFA@2|Bacteria,1N6R9@1224|Proteobacteria,1SFP8@1236|Gammaproteobacteria,1WZH8@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_1316960_1 1134474.O59_000405 1.83e-73 236.0 COG1232@1|root,COG1232@2|Bacteria,1R0ZY@1224|Proteobacteria,1T5QS@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Tryptophan halogenase - - - - - - - - - - - - Trp_halogenase k59_291601_1 1402135.SUH3_06270 2.4e-45 154.0 COG0785@1|root,COG0785@2|Bacteria,1RCP7@1224|Proteobacteria,2TSAI@28211|Alphaproteobacteria,3ZVQ8@60136|Sulfitobacter 28211|Alphaproteobacteria O Cytochrome C biogenesis protein transmembrane region ccdA - - ko:K06196 - - - - ko00000,ko02000 5.A.1.2 - - DsbD k59_291601_2 1297569.MESS2_730261 3.23e-11 61.6 COG0526@1|root,COG0526@2|Bacteria,1MZ5J@1224|Proteobacteria,2TR0C@28211|Alphaproteobacteria,43H5P@69277|Phyllobacteriaceae 28211|Alphaproteobacteria CO Thioredoxin-like tlpA - - - - - - - - - - - AhpC-TSA,Redoxin k59_121304_1 639283.Snov_2041 1.46e-72 232.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2TU0K@28211|Alphaproteobacteria,3F1F6@335928|Xanthobacteraceae 28211|Alphaproteobacteria C PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim k59_678166_1 1122135.KB893134_gene3128 6.05e-71 226.0 COG1960@1|root,COG1960@2|Bacteria,1MUTN@1224|Proteobacteria,2U38F@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_507108_1 1121035.AUCH01000017_gene2261 5.93e-27 104.0 COG2259@1|root,COG2259@2|Bacteria,1RDRZ@1224|Proteobacteria,2VS2G@28216|Betaproteobacteria,2KYXS@206389|Rhodocyclales 206389|Rhodocyclales S DoxX - - - ko:K15977 - - - - ko00000 - - - DoxX k59_507108_2 247634.GPB2148_171 1.82e-08 57.0 COG3219@1|root,COG3219@2|Bacteria,1R8C9@1224|Proteobacteria,1S23S@1236|Gammaproteobacteria,1J6PK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria - - - ko:K09929 - - - - ko00000 - - - DUF2063 k59_549634_1 1380394.JADL01000002_gene1234 6.15e-19 85.1 COG0620@1|root,COG0620@2|Bacteria,1MUI9@1224|Proteobacteria,2TTWK@28211|Alphaproteobacteria,2JUYS@204441|Rhodospirillales 204441|Rhodospirillales E Cobalamin-independent synthase, Catalytic domain - - 2.1.1.14 ko:K00549 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 M00017 R04405,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - Meth_synt_2 k59_549634_2 1121106.JQKB01000003_gene2503 1.3e-86 266.0 COG2267@1|root,COG2267@2|Bacteria,1QU7K@1224|Proteobacteria,2U0H3@28211|Alphaproteobacteria,2JV4P@204441|Rhodospirillales 204441|Rhodospirillales I Serine aminopeptidase, S33 - - - - - - - - - - - - - k59_383203_1 686340.Metal_0675 8.76e-78 236.0 COG2193@1|root,COG2193@2|Bacteria,1RAQ8@1224|Proteobacteria,1S2G2@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Bacterioferritin IV02_12050 - 1.16.3.1 ko:K03594 ko00860,map00860 - R00078 RC02758 ko00000,ko00001,ko01000 - - - Ferritin k59_383203_2 107636.JQNK01000009_gene2160 8.62e-20 87.4 COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,2TTI9@28211|Alphaproteobacteria,36ZWP@31993|Methylocystaceae 28211|Alphaproteobacteria S Alcohol dehydrogenase GroES-like domain - - 1.1.1.1 ko:K13953 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_885948_1 1246448.ANAZ01000010_gene3110 3.23e-09 57.0 COG0251@1|root,COG0251@2|Bacteria,2H01D@201174|Actinobacteria,4EQVW@85012|Streptosporangiales 201174|Actinobacteria J Endoribonuclease L-PSP - - - - - - - - - - - - Ribonuc_L-PSP k59_885948_2 85643.Tmz1t_2130 6.47e-142 412.0 COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,2VJ89@28216|Betaproteobacteria,2KVYN@206389|Rhodocyclales 206389|Rhodocyclales S tRNA-splicing ligase RtcB - - 6.5.1.3 ko:K14415 - - - - ko00000,ko01000,ko03016 - - - RtcB k59_1232041_1 1095769.CAHF01000011_gene2380 2.06e-72 231.0 COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,2VHN4@28216|Betaproteobacteria,473AW@75682|Oxalobacteraceae 28216|Betaproteobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family cysS - 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,tRNA-synt_1e,tRNA-synt_1g k59_251858_2 395963.Bind_0256 3.74e-08 54.7 COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,2TRPB@28211|Alphaproteobacteria,3NAFK@45404|Beijerinckiaceae 28211|Alphaproteobacteria L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity dnaX - 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNA_pol3_gamma3,DUF3646 k59_933624_1 1437824.BN940_02136 0.000165 41.6 COG2921@1|root,COG2921@2|Bacteria,1RGV5@1224|Proteobacteria,2VTY5@28216|Betaproteobacteria,3T4IE@506|Alcaligenaceae 28216|Betaproteobacteria S Belongs to the UPF0250 family ybeD - - ko:K09158 - - - - ko00000 - - - DUF493 k59_933624_2 159087.Daro_0290 1.26e-98 297.0 COG0115@1|root,COG0115@2|Bacteria,1MVAT@1224|Proteobacteria,2VIVK@28216|Betaproteobacteria,2KVN6@206389|Rhodocyclales 206389|Rhodocyclales EH Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase - - 2.6.1.21 ko:K00824 ko00310,ko00330,ko00360,ko00472,ko00473,ko01100,map00310,map00330,map00360,map00472,map00473,map01100 - R01148,R01582,R02459,R02851,R02924,R05053 RC00006,RC00008,RC00025 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_4 k59_163640_1 85643.Tmz1t_0199 2.11e-113 353.0 COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,2VMWP@28216|Betaproteobacteria,2KVYZ@206389|Rhodocyclales 206389|Rhodocyclales C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family padB - 1.17.5.1,3.1.2.25 ko:K18361 ko00360,map00360 - R07222,R07294 RC00004,RC01844,RC01903 ko00000,ko00001,ko01000 - - - Molybdopterin,Molydop_binding k59_590095_1 1125863.JAFN01000001_gene586 6.15e-28 116.0 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,42MFK@68525|delta/epsilon subdivisions,2WKBU@28221|Deltaproteobacteria 28221|Deltaproteobacteria E extracellular solute-binding protein, family 5 - - - ko:K02035,ko:K13893 ko02010,ko02024,map02010,map02024 M00239,M00349 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.21,3.A.1.5.24 - - SBP_bac_5 k59_340069_1 1229909.NSED_07185 5.81e-37 131.0 COG0189@1|root,arCOG01589@2157|Archaea,41SE8@651137|Thaumarchaeota 651137|Thaumarchaeota H Lysine biosynthesis - - 6.3.2.43 ko:K05827 ko00300,ko01100,ko01210,ko01230,map00300,map01100,map01210,map01230 M00031 R09775 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - RimK k59_340069_2 436308.Nmar_1294 6.27e-34 116.0 arCOG01588@1|root,arCOG01588@2157|Archaea,41STK@651137|Thaumarchaeota 651137|Thaumarchaeota E lysine biosynthesis protein LysW - - - ko:K05826 - M00031,M00763 - - ko00000,ko00001,ko00002 - - - - k59_340069_3 1131266.ARWQ01000004_gene1457 6.55e-28 110.0 COG0119@1|root,arCOG02092@2157|Archaea,41S7Y@651137|Thaumarchaeota 651137|Thaumarchaeota E HMGL-like - - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like k59_762718_1 666685.R2APBS1_0236 0.000623 44.7 COG5652@1|root,COG5652@2|Bacteria,1NGE7@1224|Proteobacteria,1SGEP@1236|Gammaproteobacteria,1X93B@135614|Xanthomonadales 135614|Xanthomonadales S PFAM VanZ - - - - - - - - - - - - - k59_911250_2 414684.RC1_2540 1.96e-08 55.1 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2TSC5@28211|Alphaproteobacteria,2JPQ5@204441|Rhodospirillales 204441|Rhodospirillales V ATPases associated with a variety of cellular activities - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_62095_1 399795.CtesDRAFT_PD3618 3.42e-101 308.0 COG0114@1|root,COG0114@2|Bacteria,1MUQI@1224|Proteobacteria,2VHA5@28216|Betaproteobacteria,4AAGV@80864|Comamonadaceae 28216|Betaproteobacteria C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate fumC - 4.2.1.2 ko:K01679 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211 M00009,M00011,M00173,M00376 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - FumaraseC_C,Lyase_1 k59_62095_2 864073.HFRIS_017027 6.09e-118 342.0 COG1741@1|root,COG1741@2|Bacteria,1MVSW@1224|Proteobacteria,2VHPA@28216|Betaproteobacteria,4734U@75682|Oxalobacteraceae 28216|Betaproteobacteria S Belongs to the pirin family yhhW_2 - - ko:K06911 - - - - ko00000 - - - Pirin k59_62095_3 94624.Bpet2554 1.99e-53 171.0 COG3118@1|root,COG3118@2|Bacteria,1RHRZ@1224|Proteobacteria,2VT09@28216|Betaproteobacteria,3T45F@506|Alcaligenaceae 28216|Betaproteobacteria O Belongs to the thioredoxin family trxC - 1.8.1.8 ko:K03671,ko:K03672 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko01000,ko03110 - - - Thioredoxin k59_568367_1 420324.KI912045_gene4585 2.09e-48 167.0 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,2TW3U@28211|Alphaproteobacteria,1JZHH@119045|Methylobacteriaceae 28211|Alphaproteobacteria V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_568367_2 204773.HEAR2618 1.32e-34 138.0 COG0457@1|root,COG0457@2|Bacteria,1NFQW@1224|Proteobacteria,2VQUC@28216|Betaproteobacteria 28216|Betaproteobacteria S Tetratricopeptide TPR_2 repeat protein - - - - - - - - - - - - TPR_16,TPR_2,TPR_8 k59_740713_1 859657.RPSI07_3248 1.76e-37 129.0 COG4274@1|root,COG4274@2|Bacteria,1MZVV@1224|Proteobacteria,2VUPM@28216|Betaproteobacteria,1K8BT@119060|Burkholderiaceae 28216|Betaproteobacteria S PFAM GYD family protein - - - - - - - - - - - - GYD k59_740713_2 323848.Nmul_A0733 1.87e-09 56.6 2ERQA@1|root,33J9N@2|Bacteria,1NI0Z@1224|Proteobacteria,2VYZY@28216|Betaproteobacteria,373P2@32003|Nitrosomonadales 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_823698_1 159087.Daro_0662 1.18e-164 476.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,2KUM4@206389|Rhodocyclales 206389|Rhodocyclales T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains pilR - - ko:K02667 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - HTH_8,Response_reg,Sigma54_activat k59_823698_2 998674.ATTE01000001_gene385 5.7e-29 118.0 COG4191@1|root,COG4191@2|Bacteria,1QU7R@1224|Proteobacteria,1T1Q4@1236|Gammaproteobacteria,461A6@72273|Thiotrichales 72273|Thiotrichales T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA k59_823709_2 1121937.AUHJ01000006_gene2459 8.72e-80 248.0 COG2141@1|root,COG2141@2|Bacteria,1MWI8@1224|Proteobacteria,1S10Y@1236|Gammaproteobacteria,468VQ@72275|Alteromonadaceae 1236|Gammaproteobacteria C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_1294182_1 1397666.RS24_01867 2.27e-16 78.2 COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,2TR81@28211|Alphaproteobacteria,4BP6R@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline argF - 2.1.3.3 ko:K00611 ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230 M00029,M00844 R01398 RC00096 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_1294182_2 438753.AZC_4028 1.04e-116 348.0 COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,2TSGT@28211|Alphaproteobacteria,3EZ5D@335928|Xanthobacteraceae 28211|Alphaproteobacteria E Aminotransferase class-III argD GO:0003674,GO:0005488,GO:0005515,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 2.6.1.11,2.6.1.17 ko:K00821 ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_318309_1 375286.mma_1078 1.02e-07 52.4 COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,2VHYE@28216|Betaproteobacteria,472E7@75682|Oxalobacteraceae 28216|Betaproteobacteria E Glutamine synthetase, catalytic domain glnA GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016866,GO:0034022,GO:0042537,GO:0044237,GO:0050486,GO:0071704,GO:1901360 5.4.4.3,6.3.1.2 ko:K01915,ko:K20712 ko00220,ko00250,ko00627,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00627,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253,R06988,R09284 RC00010,RC01754,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_318309_2 1288494.EBAPG3_1470 2.39e-28 107.0 COG0607@1|root,COG0607@2|Bacteria,1REHH@1224|Proteobacteria,2VR3P@28216|Betaproteobacteria,374M5@32003|Nitrosomonadales 28216|Betaproteobacteria P Rhodanese Homology Domain - - - - - - - - - - - - Rhodanese k59_698241_1 1479237.JMLY01000001_gene2706 1.94e-68 220.0 COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,1RM7I@1236|Gammaproteobacteria,4654T@72275|Alteromonadaceae 1236|Gammaproteobacteria C Belongs to the heme-copper respiratory oxidase family ccoN GO:0003674,GO:0003824,GO:0004129,GO:0005215,GO:0005488,GO:0005506,GO:0005507,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008144,GO:0008150,GO:0008152,GO:0008324,GO:0009055,GO:0009060,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015002,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015672,GO:0015975,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0016310,GO:0016491,GO:0016675,GO:0016676,GO:0016705,GO:0017144,GO:0019411,GO:0019637,GO:0019646,GO:0019693,GO:0019825,GO:0020037,GO:0022857,GO:0022890,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0034641,GO:0036094,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045154,GO:0045333,GO:0046034,GO:0046483,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0055114,GO:0070069,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0097159,GO:0098655,GO:0098660,GO:0098662,GO:1901135,GO:1901360,GO:1901363,GO:1901564,GO:1902600 1.9.3.1 ko:K00404 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - COX1 k59_866611_1 1123242.JH636435_gene933 3.62e-64 204.0 COG2197@1|root,COG2197@2|Bacteria,2J0EY@203682|Planctomycetes 203682|Planctomycetes K helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg k59_186639_2 935548.KI912159_gene3729 1.73e-98 290.0 COG0066@1|root,COG0066@2|Bacteria,1MVXB@1224|Proteobacteria,2TRRS@28211|Alphaproteobacteria,43GQY@69277|Phyllobacteriaceae 28211|Alphaproteobacteria E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuD - 4.2.1.33,4.2.1.35 ko:K01704 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R10170 RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase_C k59_953834_1 1197906.CAJQ02000043_gene2070 1.13e-67 223.0 COG0074@1|root,COG0074@2|Bacteria,1MWWN@1224|Proteobacteria,2TTYT@28211|Alphaproteobacteria,3JXIV@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C CoA-ligase - - - - - - - - - - - - CoA_binding,Ligase_CoA k59_1252459_2 760117.JN27_09430 1.76e-59 195.0 COG5621@1|root,COG5621@2|Bacteria,1MUVF@1224|Proteobacteria,2VHMT@28216|Betaproteobacteria,472WW@75682|Oxalobacteraceae 28216|Betaproteobacteria S Lipocalin-like domain - - - - - - - - - - - - CrtC,Lipocalin_9 k59_442415_1 1260251.SPISAL_08415 5.47e-23 97.1 COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,1RN65@1236|Gammaproteobacteria,1WWNZ@135613|Chromatiales 135613|Chromatiales K Belongs to the ParB family - - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_442415_2 1266925.JHVX01000005_gene1938 3.13e-19 84.3 COG3312@1|root,COG3312@2|Bacteria,1R3CS@1224|Proteobacteria,2WIGV@28216|Betaproteobacteria,374P5@32003|Nitrosomonadales 28216|Betaproteobacteria C ATP synthase I chain - - - ko:K02116 - - - - ko00000,ko00194 3.A.2.1 - - ATP-synt_I k59_442415_3 1288494.EBAPG3_29150 5.88e-52 172.0 COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,2VHR5@28216|Betaproteobacteria,371W5@32003|Nitrosomonadales 28216|Betaproteobacteria C it plays a direct role in the translocation of protons across the membrane atpB - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A k59_953854_1 305700.B447_01686 3.45e-47 167.0 COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,2VHAY@28216|Betaproteobacteria,2KUIC@206389|Rhodocyclales 206389|Rhodocyclales S Peptidase M48 - - - - - - - - - - - - Peptidase_M48,TPR_16,TPR_19 k59_1340741_1 395495.Lcho_3015 9.3e-107 320.0 COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,2VIHG@28216|Betaproteobacteria,1KMB7@119065|unclassified Burkholderiales 28216|Betaproteobacteria EH D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain serA - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C k59_655167_2 1454004.AW11_00950 1.22e-24 100.0 COG0664@1|root,COG0664@2|Bacteria,1RAF3@1224|Proteobacteria,2VQIC@28216|Betaproteobacteria 28216|Betaproteobacteria K Crp-like helix-turn-helix domain - - - - - - - - - - - - HTH_Crp_2 k59_1209788_1 313606.M23134_07499 3.29e-36 134.0 COG0501@1|root,COG0501@2|Bacteria,4PA0G@976|Bacteroidetes,47SGP@768503|Cytophagia 976|Bacteroidetes O Peptidase family M48 htpX - - ko:K03799 - M00743 - - ko00000,ko00002,ko01000,ko01002 - - - Peptidase_M48 k59_1209788_2 682795.AciX8_1736 1.96e-44 157.0 COG1249@1|root,COG1249@2|Bacteria,3Y3KM@57723|Acidobacteria,2JICF@204432|Acidobacteriia 204432|Acidobacteriia C Pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim k59_1167093_1 342610.Patl_3902 3.64e-56 186.0 COG1234@1|root,COG1234@2|Bacteria,1R64Z@1224|Proteobacteria,1S1KW@1236|Gammaproteobacteria,2Q5B8@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria S Beta-lactamase superfamily domain - - 3.1.26.11 ko:K00784 ko03013,map03013 - - - ko00000,ko00001,ko01000,ko03016 - - - Lactamase_B_2 k59_99715_1 1380394.JADL01000016_gene458 4.31e-45 166.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,2TR4E@28211|Alphaproteobacteria,2JQC9@204441|Rhodospirillales 204441|Rhodospirillales O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner - - - - - - - - - - - - AAA,LON_substr_bdg,Lon_C k59_442475_1 595537.Varpa_2590 4.23e-28 113.0 COG4638@1|root,COG4638@2|Bacteria,1N6MJ@1224|Proteobacteria,2VJ0B@28216|Betaproteobacteria,4AC5A@80864|Comamonadaceae 28216|Betaproteobacteria P Rieske 2Fe-2S domain protein - - - ko:K14748 ko00642,ko01100,ko01120,ko01220,map00642,map01100,map01120,map01220 - R05440 RC00098 br01602,ko00000,ko00001,ko01000 - - - Rieske,Ring_hydroxyl_A k59_442475_2 511.JT27_04960 2.79e-09 57.0 COG5517@1|root,COG5517@2|Bacteria,1RAVG@1224|Proteobacteria,2VQKZ@28216|Betaproteobacteria,3T3VK@506|Alcaligenaceae 28216|Betaproteobacteria Q Ring hydroxylating subunit beta family protein 3 - - 1.14.12.25 ko:K16303 ko00622,ko01120,ko01220,map00622,map01120,map01220 M00539 R05247 RC00267 br01602,ko00000,ko00001,ko00002,ko01000 - - - Ring_hydroxyl_B k59_186715_1 1469245.JFBG01000011_gene834 4.82e-30 113.0 COG1403@1|root,COG1403@2|Bacteria,1MWEQ@1224|Proteobacteria,1S2R0@1236|Gammaproteobacteria,1WWXG@135613|Chromatiales 135613|Chromatiales L PFAM HNH endonuclease - - - - - - - - - - - - HNH_5 k59_186715_2 91464.S7335_3946 5.77e-22 89.0 COG0776@1|root,COG0776@2|Bacteria,1G7ER@1117|Cyanobacteria,1H0RE@1129|Synechococcus 1117|Cyanobacteria L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions himA - - ko:K03530 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding k59_996465_1 1437824.BN940_08016 3.57e-108 337.0 COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,2VHYF@28216|Betaproteobacteria,3T21Y@506|Alcaligenaceae 28216|Betaproteobacteria O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_186739_1 323848.Nmul_A2338 2.85e-101 317.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,2VIAU@28216|Betaproteobacteria,3727H@32003|Nitrosomonadales 28216|Betaproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_318489_1 402881.Plav_3228 6.44e-57 192.0 COG0477@1|root,COG2814@2|Bacteria,1MVUF@1224|Proteobacteria,2TU4M@28211|Alphaproteobacteria,1JNSW@119043|Rhodobiaceae 28211|Alphaproteobacteria EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1,Sugar_tr k59_99775_1 1382303.JPOM01000001_gene334 8.37e-14 71.2 COG0318@1|root,COG0318@2|Bacteria,1MUQZ@1224|Proteobacteria,2TRV7@28211|Alphaproteobacteria,2KG8H@204458|Caulobacterales 204458|Caulobacterales IQ AMP-binding enzyme - - 6.2.1.34 ko:K12508 - - - - ko00000,ko01000 - - - AMP-binding k59_786762_1 749222.Nitsa_0867 4.37e-62 215.0 COG0474@1|root,COG0475@1|root,COG0474@2|Bacteria,COG0475@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2YNQF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P COG0474 Cation transport ATPase - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3,Na_H_Exchanger k59_62407_1 159450.NH14_10585 1.36e-100 318.0 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,2VK2H@28216|Betaproteobacteria,1K43X@119060|Burkholderiaceae 28216|Betaproteobacteria J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,IF-2,IF2_N,IF2_assoc k59_318620_1 582744.Msip34_0427 2.45e-10 65.9 COG0577@1|root,COG1136@1|root,COG0577@2|Bacteria,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,2VHZ2@28216|Betaproteobacteria,2KKWI@206350|Nitrosomonadales 206350|Nitrosomonadales V MacB-like periplasmic core domain - - - ko:K05685 ko02010,map02010 M00709 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.122.1,3.A.1.122.12 - - ABC_tran,FtsX,MacB_PCD k59_318620_2 903818.KI912269_gene135 1.61e-18 83.6 COG1136@1|root,COG1136@2|Bacteria,3Y30Q@57723|Acidobacteria 57723|Acidobacteria V ABC transporter - - - - - - - - - - - - ABC_tran k59_1209975_1 1205680.CAKO01000002_gene3006 5.71e-47 162.0 COG0559@1|root,COG0559@2|Bacteria,1P3FU@1224|Proteobacteria,2TT3V@28211|Alphaproteobacteria,2JTCX@204441|Rhodospirillales 204441|Rhodospirillales E COG0559 Branched-chain amino acid ABC-type transport system, permease components - - - - - - - - - - - - BPD_transp_2 k59_911601_1 580332.Slit_1327 1.66e-40 153.0 COG2203@1|root,COG3829@1|root,COG4251@1|root,COG2203@2|Bacteria,COG3829@2|Bacteria,COG4251@2|Bacteria,1RGKE@1224|Proteobacteria,2WHFM@28216|Betaproteobacteria,44WPK@713636|Nitrosomonadales 28216|Betaproteobacteria T SMART ATP-binding region ATPase domain protein - - - - - - - - - - - - HATPase_c,HisKA,PAS_4 k59_18380_2 1121106.JQKB01000130_gene1633 2.24e-10 63.2 COG2141@1|root,COG2141@2|Bacteria,1MWDV@1224|Proteobacteria,2TV51@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - - - - - - - - - - Bac_luciferase k59_1210044_2 1282876.BAOK01000001_gene1844 2.66e-35 130.0 COG0491@1|root,COG0491@2|Bacteria,1N22F@1224|Proteobacteria,2U2V5@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_741100_1 1247649.D560_0985 6.24e-93 306.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2VI87@28216|Betaproteobacteria,3T1BB@506|Alcaligenaceae 28216|Betaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA2 - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_911656_1 93220.LV28_10640 1.68e-28 119.0 COG0642@1|root,COG0642@2|Bacteria,1QTSX@1224|Proteobacteria,2VI80@28216|Betaproteobacteria,1K48Q@119060|Burkholderiaceae 28216|Betaproteobacteria T Histidine kinase - - 2.7.13.3 ko:K07649 ko02020,map02020 M00457 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - 2CSK_N,HATPase_c,HisKA k59_954147_1 479434.Sthe_1400 1.19e-66 214.0 COG1319@1|root,COG1319@2|Bacteria,2G60Y@200795|Chloroflexi,27XP9@189775|Thermomicrobia 189775|Thermomicrobia C CO dehydrogenase flavoprotein C-terminal domain - - 1.2.5.3 ko:K03519 - - R11168 RC02800 ko00000,ko01000 - - - CO_deh_flav_C,FAD_binding_5 k59_186967_1 525904.Tter_0968 1.18e-56 189.0 COG0489@1|root,COG0489@2|Bacteria,2NNX1@2323|unclassified Bacteria 2|Bacteria D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP mrp - - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - FeS_assembly_P,ParA k59_787015_1 228410.NE1321 1.34e-05 46.2 COG1183@1|root,COG1183@2|Bacteria,1MWD9@1224|Proteobacteria,2VIME@28216|Betaproteobacteria,3725D@32003|Nitrosomonadales 28216|Betaproteobacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pssA - 2.7.8.8 ko:K17103 ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110 M00093 R01800 RC00002,RC00017,RC02795 ko00000,ko00001,ko00002,ko01000 - - - CDP-OH_P_transf k59_787015_2 1198452.Jab_2c18520 4.01e-21 90.9 COG1183@1|root,COG1183@2|Bacteria,1MWD9@1224|Proteobacteria,2VIME@28216|Betaproteobacteria,47382@75682|Oxalobacteraceae 28216|Betaproteobacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pssA - 2.7.8.8 ko:K17103 ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110 M00093 R01800 RC00002,RC00017,RC02795 ko00000,ko00001,ko00002,ko01000 - - - CDP-OH_P_transf k59_787015_3 948106.AWZT01000021_gene2939 4.67e-48 167.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,2VI4G@28216|Betaproteobacteria,1K2XH@119060|Burkholderiaceae 28216|Betaproteobacteria E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) leuA - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_1252812_1 580332.Slit_1710 6.83e-61 193.0 COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,2VKVM@28216|Betaproteobacteria,44W9R@713636|Nitrosomonadales 28216|Betaproteobacteria C 4Fe-4S binding domain - - - ko:K21308 ko00920,ko01100,ko01120,map00920,map01100,map01120 - R11487 RC00168 ko00000,ko00001 - - - Fer4_11,Fer4_4 k59_1252812_2 1163617.SCD_n01211 9.94e-31 117.0 COG3302@1|root,COG3302@2|Bacteria,1MWY1@1224|Proteobacteria,2VN4W@28216|Betaproteobacteria 28216|Betaproteobacteria S DMSO reductase anchor subunit (DmsC) dmsC - - ko:K21309 ko00920,ko01100,ko01120,map00920,map01100,map01120 - R11487 RC00168 ko00000,ko00001 - - - DmsC k59_698596_1 748280.NH8B_1731 8.88e-30 118.0 COG1875@1|root,COG1875@2|Bacteria,1MUX1@1224|Proteobacteria,2VH4P@28216|Betaproteobacteria,2KQAF@206351|Neisseriales 206351|Neisseriales T Large family of predicted nucleotide-binding domains - - - ko:K07175 - - - - ko00000 - - - PIN_4,PhoH k59_698596_2 757424.Hsero_2083 8.44e-52 167.0 COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,2VR4P@28216|Betaproteobacteria,4743H@75682|Oxalobacteraceae 28216|Betaproteobacteria O Redoxin bcp GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008379,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044464,GO:0045454,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0051920,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA k59_954178_1 631362.Thi970DRAFT_04731 1.24e-67 228.0 COG0466@1|root,COG0466@2|Bacteria,1NTR5@1224|Proteobacteria,1RPID@1236|Gammaproteobacteria,1WWG2@135613|Chromatiales 135613|Chromatiales O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner - - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_1210130_1 1469245.JFBG01000052_gene2163 1.95e-36 135.0 COG2515@1|root,COG2515@2|Bacteria,1MVYF@1224|Proteobacteria,1RMYP@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the alpha,beta-elimination reaction of D- cysteine and of several D-cysteine derivatives. It could be a defense mechanism against D-cysteine - - 4.4.1.15,4.4.1.25 ko:K05396,ko:K17950 ko00270,map00270 - R01874,R07634 RC00382,RC01784 ko00000,ko00001,ko01000 - - - PALP k59_1210130_2 1158292.JPOE01000002_gene2199 7.03e-08 51.2 COG4319@1|root,COG4319@2|Bacteria,1RD4M@1224|Proteobacteria,2VVSD@28216|Betaproteobacteria,1KPE9@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Protein of unknown function (DUF3225) - - - - - - - - - - - - DUF3225 k59_568779_1 158500.BV97_01206 8.76e-07 56.2 COG1028@1|root,COG1028@2|Bacteria,1MU3W@1224|Proteobacteria,2TT5X@28211|Alphaproteobacteria,2K05I@204457|Sphingomonadales 204457|Sphingomonadales IQ Short-chain dehydrogenase reductase sdr - - - - - - - - - - - - adh_short_C2 k59_62708_1 552811.Dehly_1039 1.05e-15 79.0 COG0154@1|root,COG0154@2|Bacteria,2G5T0@200795|Chloroflexi,34CJK@301297|Dehalococcoidia 301297|Dehalococcoidia J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_62708_2 338969.Rfer_2852 3.56e-170 487.0 COG0657@1|root,COG0657@2|Bacteria 2|Bacteria I acetylesterase activity cytC6 - - - - - - - - - - - Abhydrolase_3,EB_dh k59_655492_1 1370120.AUWR01000012_gene1231 4.28e-107 321.0 COG1804@1|root,COG1804@2|Bacteria,2GKNX@201174|Actinobacteria,234U5@1762|Mycobacteriaceae 201174|Actinobacteria C carnitine dehydratase mcr - 5.1.99.4 ko:K01796 ko00120,ko01100,ko04146,map00120,map01100,map04146 M00104 R08734,R08739 RC02345 ko00000,ko00001,ko00002,ko01000 - - - CoA_transf_3 k59_1210162_1 1122975.AQVC01000009_gene1494 1.42e-13 76.3 COG3464@1|root,COG3464@2|Bacteria,4PNJ1@976|Bacteroidetes,2FXBK@200643|Bacteroidia 976|Bacteroidetes L Transposase IS66 family - - - - - - - - - - - - DDE_Tnp_IS66 k59_828365_1 395494.Galf_1266 5.28e-63 214.0 COG1596@1|root,COG1596@2|Bacteria,1N7GP@1224|Proteobacteria,2VJBU@28216|Betaproteobacteria 28216|Betaproteobacteria M polysaccharide export protein kpsD - - - - - - - - - - - Caps_synth_GfcC,Poly_export,SLBB k59_274986_1 713586.KB900536_gene1209 1.72e-67 212.0 COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,1RPKN@1236|Gammaproteobacteria,1WWR2@135613|Chromatiales 135613|Chromatiales T response regulator receiver - - - ko:K07659 ko02020,ko02026,map02020,map02026 M00445,M00742,M00743 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_573272_1 272626.lin2082 4.98e-45 158.0 COG0389@1|root,COG0389@2|Bacteria,1TP42@1239|Firmicutes,4HADJ@91061|Bacilli,26ISU@186820|Listeriaceae 91061|Bacilli L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII dinB GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 2.7.7.7 ko:K02346 - - - - ko00000,ko01000,ko03400 - - - IMS,IMS_C,IMS_HHH k59_828380_1 318996.AXAZ01000019_gene1790 5.01e-39 144.0 COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,2TS6X@28211|Alphaproteobacteria,3JWIG@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Putative transposase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_916778_1 265072.Mfla_1744 8.9e-11 69.3 COG3164@1|root,COG3164@2|Bacteria,1MXWF@1224|Proteobacteria,2VH52@28216|Betaproteobacteria,2KKF5@206350|Nitrosomonadales 206350|Nitrosomonadales S Protein of unknown function - - - - - - - - - - - - AsmA_2,DUF3971 k59_738494_1 261292.Nit79A3_0841 9.27e-80 252.0 COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,2VHR6@28216|Betaproteobacteria,372MN@32003|Nitrosomonadales 28216|Betaproteobacteria E Threonine synthase thrC - 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - - PALP,Thr_synth_N k59_1250124_1 395493.BegalDRAFT_3125 6e-169 487.0 COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,1RPTT@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the binding-protein-dependent transport system permease family livM GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015173,GO:0015175,GO:0015179,GO:0015188,GO:0015192,GO:0015238,GO:0015318,GO:0015658,GO:0015711,GO:0015801,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015823,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1902475,GO:1903714,GO:1903785,GO:1903825,GO:1905039 - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - iPC815.YPO3806,iSDY_1059.SDY_3605 BPD_transp_2,DUF3382 k59_1250124_2 1437448.AZRT01000002_gene2265 1.65e-15 75.5 COG0411@1|root,COG3743@1|root,COG0411@2|Bacteria,COG3743@2|Bacteria,1MUTY@1224|Proteobacteria,2TQK1@28211|Alphaproteobacteria,1J1DE@118882|Brucellaceae 28211|Alphaproteobacteria E AAA domain braF GO:0003333,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0015711,GO:0015803,GO:0015804,GO:0015807,GO:0015808,GO:0015818,GO:0015829,GO:0015849,GO:0015893,GO:0032328,GO:0034220,GO:0042221,GO:0042493,GO:0042940,GO:0042941,GO:0043090,GO:0046942,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098739,GO:1902475,GO:1903714,GO:1903785,GO:1903805,GO:1903806,GO:1903825,GO:1905039 3.5.4.44 ko:K01995,ko:K15783 ko00260,ko01100,ko02010,ko02024,map00260,map01100,map02010,map02024 M00237 R09800 RC02661 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_738513_1 991905.SL003B_0175 1.83e-40 140.0 COG0566@1|root,COG0566@2|Bacteria,1REIN@1224|Proteobacteria,2U76Y@28211|Alphaproteobacteria,4BQ4J@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria J SpoU rRNA Methylase family - - - - - - - - - - - - SpoU_methylase k59_1082707_1 357809.Cphy_2182 6.31e-07 57.8 COG1752@1|root,COG1752@2|Bacteria,1UBYN@1239|Firmicutes,247V3@186801|Clostridia,21YMK@1506553|Lachnoclostridium 186801|Clostridia S Patatin-like phospholipase - - - ko:K07001 - - - - ko00000 - - - Patatin k59_482734_1 1121004.ATVC01000051_gene1783 6.3e-28 110.0 COG2270@1|root,COG2270@2|Bacteria,1QUVA@1224|Proteobacteria,2WHTQ@28216|Betaproteobacteria,2KU4X@206351|Neisseriales 206351|Neisseriales S AmpG muropeptide MFS transporter K08218 - - - ko:K08218 ko01501,map01501 M00628 - - ko00000,ko00001,ko00002,ko02000 2.A.1.25 - - MFS_1 k59_482734_2 1123401.JHYQ01000029_gene1956 2.71e-105 311.0 COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,1RN4H@1236|Gammaproteobacteria,4606Q@72273|Thiotrichales 72273|Thiotrichales L Exodeoxyribonuclease III xth xth - 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos k59_613865_1 1123372.AUIT01000022_gene984 1.33e-21 97.4 COG1566@1|root,COG1566@2|Bacteria,2GHFR@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria V HlyD family secretion protein - - - ko:K01993 - - - - ko00000 - - - HlyD_D23 k59_1337837_1 420324.KI911934_gene172 3.11e-30 116.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,1JXEF@119045|Methylobacteriaceae 28211|Alphaproteobacteria L Transposase - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_738533_1 640081.Dsui_2340 7.05e-33 124.0 COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,2VKHP@28216|Betaproteobacteria,2KWV0@206389|Rhodocyclales 206389|Rhodocyclales V ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 k59_738533_2 414684.RC1_2057 5.56e-124 363.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2TR2P@28211|Alphaproteobacteria,2JYV7@204441|Rhodospirillales 204441|Rhodospirillales V AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_226764_1 1121866.AUGK01000002_gene1525 1.83e-60 210.0 COG0188@1|root,COG0188@2|Bacteria,2GJ2Q@201174|Actinobacteria,4CU8E@84998|Coriobacteriia 84998|Coriobacteriia L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k59_397314_1 402881.Plav_1767 5.19e-102 303.0 COG1028@1|root,COG1028@2|Bacteria,1PFUB@1224|Proteobacteria,2U149@28211|Alphaproteobacteria,1JQM5@119043|Rhodobiaceae 28211|Alphaproteobacteria IQ PFAM short-chain dehydrogenase reductase SDR - - - ko:K13774 ko00281,map00281 - R08087,R08096,R10125,R10126 RC00080,RC00087 ko00000,ko00001 - - - adh_short_C2 k59_909101_1 187272.Mlg_2843 2.31e-33 128.0 COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,1RMW3@1236|Gammaproteobacteria,1WXEF@135613|Chromatiales 135613|Chromatiales G Belongs to the pyruvate kinase family - - 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PK,PK_C k59_909101_2 1038869.AXAN01000022_gene1934 6.45e-14 72.4 COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,2VIWI@28216|Betaproteobacteria,1K590@119060|Burkholderiaceae 28216|Betaproteobacteria S penicillin amidase - - 3.5.1.11 ko:K01434 ko00311,ko01130,map00311,map01130 - R02170 RC00166,RC00328 ko00000,ko00001,ko01000,ko01002 - - - Penicil_amidase k59_951606_1 502025.Hoch_4546 2.54e-69 231.0 COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,42ZB2@68525|delta/epsilon subdivisions,2WUMC@28221|Deltaproteobacteria,2YUFT@29|Myxococcales 28221|Deltaproteobacteria C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - 1.3.99.16 ko:K07303 - - - - ko00000,ko01000 - - - Ald_Xan_dh_C2 k59_1292178_1 1123368.AUIS01000004_gene115 4.25e-116 365.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,2NDJD@225057|Acidithiobacillales 225057|Acidithiobacillales T Diguanylate cyclase - - - - - - - - - - - - EAL,GAF_2,GGDEF,PAS_4,Response_reg k59_440235_1 159087.Daro_3387 1.61e-109 328.0 COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,2VJ7K@28216|Betaproteobacteria,2KURU@206389|Rhodocyclales 206389|Rhodocyclales E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine hisD - 1.1.1.23 ko:K00013 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 - - - Histidinol_dh k59_994258_1 414684.RC1_3822 1.81e-45 168.0 COG3898@1|root,COG3898@2|Bacteria,1R052@1224|Proteobacteria 1224|Proteobacteria S HemY domain protein - - - - - - - - - - - - - k59_1250261_1 991905.SL003B_0089 6.11e-22 89.7 COG1403@1|root,COG1403@2|Bacteria,1MWEQ@1224|Proteobacteria,2TR3M@28211|Alphaproteobacteria,4BQ20@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria L HNH nucleases MA20_20605 - - - - - - - - - - - HNH,HNH_5 k59_1250261_2 78245.Xaut_3842 9.51e-13 67.4 COG0400@1|root,COG0400@2|Bacteria,1RA02@1224|Proteobacteria,2TTWP@28211|Alphaproteobacteria,3EZFC@335928|Xanthobacteraceae 28211|Alphaproteobacteria S PFAM phospholipase Carboxylesterase - - - ko:K06999 - - - - ko00000 - - - Abhydrolase_2 k59_525555_1 1111732.AZOD01000014_gene1509 2.69e-46 170.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMDS@1236|Gammaproteobacteria,1X37S@135614|Xanthomonadales 135614|Xanthomonadales J Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs rne - 3.1.26.12 ko:K08300 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_1040480_1 883126.HMPREF9710_02828 6.37e-31 116.0 COG2267@1|root,COG2267@2|Bacteria,1NTH9@1224|Proteobacteria,2WGMM@28216|Betaproteobacteria,473PT@75682|Oxalobacteraceae 28216|Betaproteobacteria I Serine aminopeptidase, S33 - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6,Hydrolase_4 k59_1040480_2 1380394.JADL01000002_gene1603 3.45e-80 253.0 COG1024@1|root,COG1024@2|Bacteria,1NTWU@1224|Proteobacteria,2UPY0@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Enoyl-CoA hydratase/isomerase - - - - - - - - - - - - ECH_1 k59_15957_1 313612.L8106_06734 2.68e-20 89.0 COG0412@1|root,COG0412@2|Bacteria,1G3JS@1117|Cyanobacteria,1HA80@1150|Oscillatoriales 1117|Cyanobacteria Q Dienelactone hydrolase family - - 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 - R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 - - - DLH k59_15957_3 1283300.ATXB01000002_gene3058 7.73e-19 80.9 COG0861@1|root,COG0861@2|Bacteria 2|Bacteria P Integral membrane protein TerC family - - - - - - - - - - - - PGPGW k59_1120403_1 1415780.JPOG01000001_gene1333 1.06e-64 219.0 COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,1RN5I@1236|Gammaproteobacteria,1X3SP@135614|Xanthomonadales 135614|Xanthomonadales C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate acnA - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_566614_1 1267535.KB906767_gene4061 3.56e-48 169.0 COG2204@1|root,COG2204@2|Bacteria,3Y38J@57723|Acidobacteria 57723|Acidobacteria T Response regulator receiver - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_1250334_1 1333998.M2A_2413 9.2e-35 129.0 COG0500@1|root,COG2226@2|Bacteria,1PPKI@1224|Proteobacteria,2TRIB@28211|Alphaproteobacteria,4BSGF@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria Q ubiE/COQ5 methyltransferase family MA20_37085 - - - - - - - - - - - Methyltransf_11,Methyltransf_25 k59_653199_1 1165096.ARWF01000001_gene1257 1.21e-85 265.0 COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,2VHP5@28216|Betaproteobacteria,2KKSW@206350|Nitrosomonadales 206350|Nitrosomonadales C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis - - - ko:K00412 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko03029 - - - Cytochrom_B_C,Cytochrome_B k59_653199_2 748247.AZKH_0858 1.03e-18 83.6 COG2857@1|root,COG2857@2|Bacteria,1QFU2@1224|Proteobacteria,2VIR6@28216|Betaproteobacteria,2KUIS@206389|Rhodocyclales 206389|Rhodocyclales P Cytochrome C1 petC - - ko:K00413 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002 - - - Cytochrom_C1 k59_440348_1 118168.MC7420_1478 1.77e-35 142.0 COG0642@1|root,COG2202@1|root,COG5000@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,COG5000@2|Bacteria,1G2I4@1117|Cyanobacteria,1H7VC@1150|Oscillatoriales 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9 k59_1083036_1 331869.BAL199_16353 6.2e-109 333.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TSTW@28211|Alphaproteobacteria,4BPZA@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria EH Belongs to the TPP enzyme family - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1040630_1 373994.Riv7116_0376 9.98e-45 167.0 COG0457@1|root,COG3914@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria,1G0YS@1117|Cyanobacteria,1HMAW@1161|Nostocales 1117|Cyanobacteria O Glycosyl transferase family 41 - - - - - - - - - - - - Glyco_transf_41,Sulfotransfer_2,TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8 k59_1040630_2 1266925.JHVX01000001_gene2629 4.05e-24 102.0 COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2WGHZ@28216|Betaproteobacteria,37225@32003|Nitrosomonadales 28216|Betaproteobacteria IQ AMP-dependent synthetase - - - - - - - - - - - - AMP-binding,Acyltransferase,PP-binding k59_909354_1 1123487.KB892857_gene2455 5.72e-87 269.0 COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,2VH9J@28216|Betaproteobacteria,2KUEI@206389|Rhodocyclales 206389|Rhodocyclales F Belongs to the GARS family purD - 6.3.4.13 ko:K01945 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144 RC00090,RC00166 ko00000,ko00001,ko00002,ko01000 - - - GARS_A,GARS_C,GARS_N k59_696278_1 1122135.KB893134_gene3180 1.8e-103 334.0 COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,2TS89@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Dehydrogenase gdhB GO:0003674,GO:0003824,GO:0004352,GO:0004353,GO:0008150,GO:0008152,GO:0016491,GO:0016638,GO:0016639,GO:0055114 1.4.1.2 ko:K15371 ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100 - R00243 RC00006,RC02799 ko00000,ko00001,ko01000 - - - Bac_GDH k59_268400_1 330214.NIDE3496 4.42e-34 129.0 COG0586@1|root,COG0607@1|root,COG0586@2|Bacteria,COG0607@2|Bacteria,3J1E4@40117|Nitrospirae 40117|Nitrospirae P Evidence 4 Homologs of previously reported genes of - - - ko:K03975 - - - - ko00000 - - - Rhodanese,SNARE_assoc k59_397603_1 1485544.JQKP01000003_gene148 1.51e-39 150.0 COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,2VH7P@28216|Betaproteobacteria,44V8A@713636|Nitrosomonadales 28216|Betaproteobacteria L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parC - - ko:K02621 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseA_C,DNA_topoisoIV k59_653320_1 266117.Rxyl_1929 3.53e-79 259.0 COG1067@1|root,COG1067@2|Bacteria,2H2TE@201174|Actinobacteria 201174|Actinobacteria O AAA domain - - - - - - - - - - - - AAA_32,Lon_C k59_1040736_1 522306.CAP2UW1_3571 2.31e-26 108.0 COG0591@1|root,COG0591@2|Bacteria,1MUBI@1224|Proteobacteria,2VHA8@28216|Betaproteobacteria,1KQEE@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family putP - - ko:K14392 - - - - ko00000,ko02000 2.A.21.1 - - SSF k59_1040736_2 243160.BMA0062 2.47e-33 127.0 COG5652@1|root,COG5652@2|Bacteria,1PJUW@1224|Proteobacteria,2VHEZ@28216|Betaproteobacteria,1K488@119060|Burkholderiaceae 28216|Betaproteobacteria S PFAM VanZ family protein - - - - - - - - - - - - VanZ k59_483110_1 456442.Mboo_0204 1.07e-28 117.0 COG0674@1|root,arCOG01608@2157|Archaea,2XTB0@28890|Euryarchaeota,2NA7I@224756|Methanomicrobia 224756|Methanomicrobia C PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein porA-2 - 1.2.7.1 ko:K00169 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR_N k59_16181_1 630626.EBL_c21830 3.04e-103 312.0 COG5565@1|root,COG5565@2|Bacteria,1R6R3@1224|Proteobacteria,1RY0J@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Terminase-like family - - - - - - - - - - - - Terminase_6,Terminase_6C k59_614352_1 983545.Glaag_1530 1.48e-61 204.0 COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,1RQ3D@1236|Gammaproteobacteria,4688W@72275|Alteromonadaceae 1236|Gammaproteobacteria H AMP-binding enzyme C-terminal domain - - 6.2.1.30 ko:K01912 ko00360,ko01120,ko05111,map00360,map01120,map05111 - R02539 RC00004,RC00014 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C_2 k59_1292495_1 1218076.BAYB01000059_gene6260 2.88e-114 359.0 COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2VJGC@28216|Betaproteobacteria,1K37E@119060|Burkholderiaceae 28216|Betaproteobacteria C oxidoreductase porG - 1.2.7.8 ko:K04090 - - - - br01601,ko00000,ko01000 - - - POR,TPP_enzyme_C k59_315990_1 1380394.JADL01000003_gene5081 9.16e-67 222.0 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,2JR1T@204441|Rhodospirillales 204441|Rhodospirillales T Adenylyl- / guanylyl cyclase, catalytic domain - - - - - - - - - - - - Guanylate_cyc,TPR_19 k59_357974_1 1266925.JHVX01000003_gene416 3.6e-145 423.0 COG0501@1|root,COG0501@2|Bacteria,1MUXT@1224|Proteobacteria,2VI1Y@28216|Betaproteobacteria,372MW@32003|Nitrosomonadales 28216|Betaproteobacteria O PFAM Peptidase M48 htpX_2 - 3.4.24.84 ko:K06013 ko00900,ko01130,map00900,map01130 - R09845 RC00141 ko00000,ko00001,ko01000,ko01002,ko04147 - - - Peptidase_M48,Peptidase_M48_N k59_357974_2 580332.Slit_1040 2.75e-44 146.0 COG2154@1|root,COG2154@2|Bacteria,1MZ5Q@1224|Proteobacteria,2VVZF@28216|Betaproteobacteria 28216|Betaproteobacteria H pterin-4-alpha-carbinolamine dehydratase - - 4.2.1.96 ko:K01724 ko00790,map00790 - R04734 RC01208 ko00000,ko00001,ko01000,ko04147 - - - Pterin_4a k59_357974_4 1163617.SCD_n02047 1.37e-31 120.0 COG1270@1|root,COG1270@2|Bacteria,1MWCK@1224|Proteobacteria,2VH7X@28216|Betaproteobacteria 28216|Betaproteobacteria H Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group cobD - 6.3.1.10 ko:K02227 ko00860,ko01100,map00860,map01100 M00122 R06529,R07302 RC00090,RC00096 ko00000,ko00001,ko00002,ko01000 - - - CobD_Cbib k59_784280_1 59538.XP_005973291.1 5.08e-05 44.7 COG0137@1|root,KOG1706@2759|Eukaryota,38BMZ@33154|Opisthokonta,3BAUF@33208|Metazoa,3CSN2@33213|Bilateria,47ZZH@7711|Chordata,494WS@7742|Vertebrata,3J8IS@40674|Mammalia 33208|Metazoa E argininosuccinate synthase ASS1 GO:0000050,GO:0000052,GO:0000053,GO:0000323,GO:0001101,GO:0001505,GO:0001655,GO:0001822,GO:0001889,GO:0002237,GO:0002376,GO:0002526,GO:0003674,GO:0003824,GO:0004055,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005739,GO:0005740,GO:0005741,GO:0005764,GO:0005773,GO:0005783,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006531,GO:0006575,GO:0006807,GO:0006950,GO:0006952,GO:0006953,GO:0006954,GO:0006955,GO:0007162,GO:0007275,GO:0007494,GO:0007517,GO:0007568,GO:0007584,GO:0007623,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009066,GO:0009084,GO:0009410,GO:0009605,GO:0009607,GO:0009617,GO:0009636,GO:0009719,GO:0009725,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010033,GO:0010035,GO:0010038,GO:0010043,GO:0010046,GO:0010243,GO:0012505,GO:0014070,GO:0014074,GO:0014075,GO:0015643,GO:0016020,GO:0016053,GO:0016597,GO:0016874,GO:0016879,GO:0019222,GO:0019627,GO:0019752,GO:0019867,GO:0022407,GO:0022408,GO:0030155,GO:0031090,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031406,GO:0031667,GO:0031960,GO:0031966,GO:0031967,GO:0031968,GO:0031975,GO:0032355,GO:0032496,GO:0032501,GO:0032502,GO:0032870,GO:0033554,GO:0033762,GO:0033993,GO:0034097,GO:0034201,GO:0034341,GO:0034405,GO:0034612,GO:0034616,GO:0034641,GO:0035295,GO:0035690,GO:0036094,GO:0036477,GO:0042221,GO:0042493,GO:0042802,GO:0042995,GO:0043005,GO:0043025,GO:0043167,GO:0043168,GO:0043177,GO:0043200,GO:0043204,GO:0043207,GO:0043209,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043434,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044297,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045087,GO:0045428,GO:0045429,GO:0046394,GO:0046683,GO:0048511,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048545,GO:0048565,GO:0048731,GO:0048732,GO:0048856,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051384,GO:0051591,GO:0051704,GO:0051707,GO:0051716,GO:0055123,GO:0060359,GO:0060416,GO:0060538,GO:0060539,GO:0060541,GO:0061008,GO:0061061,GO:0065007,GO:0065008,GO:0070542,GO:0070852,GO:0070887,GO:0071216,GO:0071219,GO:0071222,GO:0071229,GO:0071230,GO:0071242,GO:0071310,GO:0071320,GO:0071345,GO:0071346,GO:0071356,GO:0071375,GO:0071377,GO:0071383,GO:0071384,GO:0071385,GO:0071396,GO:0071398,GO:0071400,GO:0071407,GO:0071417,GO:0071418,GO:0071466,GO:0071495,GO:0071498,GO:0071499,GO:0071548,GO:0071549,GO:0071704,GO:0071941,GO:0072001,GO:0072350,GO:0097327,GO:0097458,GO:0098588,GO:0098805,GO:0120025,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901652,GO:1901653,GO:1901654,GO:1901655,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1903037,GO:1903038,GO:1903426,GO:1903428,GO:1904407,GO:2000377,GO:2000379 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Arginosuc_synth k59_784280_2 1163617.SCD_n02185 1.29e-115 337.0 COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,2VIVG@28216|Betaproteobacteria 28216|Betaproteobacteria E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline argF GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3 ko:K00611 ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230 M00029,M00844 R01398 RC00096 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_614396_1 1244869.H261_03133 7.17e-85 262.0 COG1775@1|root,COG1775@2|Bacteria,1NKED@1224|Proteobacteria,2U31W@28211|Alphaproteobacteria 28211|Alphaproteobacteria E benzoyl-CoA reductase - - 1.3.7.8 ko:K04113 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00541 R02451 RC00002,RC01839 ko00000,ko00001,ko00002,ko01000 - - - HGD-D k59_614396_2 316057.RPD_1536 7.49e-20 88.2 COG1924@1|root,COG1924@2|Bacteria,1R411@1224|Proteobacteria,2U1DN@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Benzoyl-CoA reductase subunit - - 1.3.7.8 ko:K04114 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00541 R02451 RC00002,RC01839 ko00000,ko00001,ko00002,ko01000 - - - BcrAD_BadFG k59_566843_1 1458716.W8FP51_9CAUD 5.22e-18 89.4 4QZQB@35237|dsDNA viruses no RNA stage,4QTX7@28883|Caudovirales,4QP1A@10744|Podoviridae 10744|Podoviridae S exonuclease activity - - - - - - - - - - - - - k59_789310_2 744980.TRICHSKD4_5670 6.35e-71 226.0 COG1363@1|root,COG1363@2|Bacteria,1MXEU@1224|Proteobacteria,2TSPX@28211|Alphaproteobacteria 28211|Alphaproteobacteria G COG1363 Cellulase M and related proteins - - - - - - - - - - - - Peptidase_M42 k59_1124045_1 667632.KB890188_gene3304 1.23e-94 289.0 COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,2VH0S@28216|Betaproteobacteria,1K1ET@119060|Burkholderiaceae 28216|Betaproteobacteria D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ - - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin k59_570394_1 78245.Xaut_0995 2.53e-46 166.0 COG0515@1|root,COG0790@1|root,COG0515@2|Bacteria,COG0790@2|Bacteria,1QA6R@1224|Proteobacteria,2TS3G@28211|Alphaproteobacteria,3F05W@335928|Xanthobacteraceae 28211|Alphaproteobacteria KLT Protein tyrosine kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase,Sel1 k59_101631_1 700512.G8CTD0_9CAUD 7.69e-45 166.0 4QAKM@10239|Viruses,4QUU7@35237|dsDNA viruses no RNA stage,4QPEF@28883|Caudovirales,4QKNE@10699|Siphoviridae 10699|Siphoviridae S DNA polymerase family A - GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 - - - - - - - - - - - k59_657260_1 243160.BMA0453 0.000319 46.6 COG0457@1|root,COG0859@1|root,COG0457@2|Bacteria,COG0859@2|Bacteria,1MUZK@1224|Proteobacteria,2VR7H@28216|Betaproteobacteria,1K1TE@119060|Burkholderiaceae 28216|Betaproteobacteria M repeat-containing protein - - - - - - - - - - - - Glyco_transf_9,TPR_1,TPR_11,TPR_16,TPR_2,TPR_4,TPR_8 k59_1124070_1 1238182.C882_3147 1.52e-32 130.0 COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,2TU7G@28211|Alphaproteobacteria,2JQT9@204441|Rhodospirillales 204441|Rhodospirillales O Belongs to the peptidase S16 family - - - - - - - - - - - - AAA_32,Lon_C k59_825664_1 1120956.JHZK01000006_gene615 7.09e-27 103.0 COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,2TTVR@28211|Alphaproteobacteria,1JPKX@119043|Rhodobiaceae 28211|Alphaproteobacteria O Glutathione S-transferase, N-terminal domain - - - ko:K11209 - - - - ko00000,ko01000 - - - GST_C,GST_C_2,GST_N,GST_N_3 k59_825664_2 1280949.HAD_00125 1.24e-21 94.0 COG0673@1|root,COG0673@2|Bacteria,1MZIG@1224|Proteobacteria,2UB61@28211|Alphaproteobacteria,43YUF@69657|Hyphomonadaceae 28211|Alphaproteobacteria E Oxidoreductase - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_1169324_1 1177928.TH2_19944 4.51e-99 310.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria,2JPCQ@204441|Rhodospirillales 204441|Rhodospirillales P COG2217 Cation transport ATPase - - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase,YHS k59_956087_1 1054213.HMPREF9946_03222 3.52e-21 95.9 COG2271@1|root,COG2271@2|Bacteria,1R8Q1@1224|Proteobacteria,2U16E@28211|Alphaproteobacteria,2JV4J@204441|Rhodospirillales 204441|Rhodospirillales G Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_956087_2 335543.Sfum_1142 2.91e-20 87.0 COG1846@1|root,COG1846@2|Bacteria,1N7G0@1224|Proteobacteria,42VBH@68525|delta/epsilon subdivisions,2WRGD@28221|Deltaproteobacteria,2MS6M@213462|Syntrophobacterales 28221|Deltaproteobacteria K helix_turn_helix multiple antibiotic resistance protein - - - - - - - - - - - - MarR,MarR_2 k59_1045904_1 864051.BurJ1DRAFT_1668 2.7e-81 252.0 COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,2VI13@28216|Betaproteobacteria,1KJEP@119065|unclassified Burkholderiales 28216|Betaproteobacteria NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR cheB - 3.1.1.61,3.5.1.44 ko:K03412 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,Response_reg k59_1254731_1 1121288.AULL01000015_gene210 6.39e-06 53.5 COG3291@1|root,COG3291@2|Bacteria,4NG09@976|Bacteroidetes,1HY3Z@117743|Flavobacteriia,3ZPCK@59732|Chryseobacterium 976|Bacteroidetes S Metalloprotease - - - - - - - - - - - - FTP,PA,PKD,Peptidase_M36 k59_825693_1 1123368.AUIS01000007_gene2692 1.69e-49 173.0 COG0143@1|root,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,1RMYM@1236|Gammaproteobacteria,2NCDZ@225057|Acidithiobacillales 225057|Acidithiobacillales J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG - 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1g,tRNA_bind k59_825693_2 1165096.ARWF01000001_gene16 3e-22 95.9 COG2114@1|root,COG2114@2|Bacteria,1RD0X@1224|Proteobacteria,2VS0D@28216|Betaproteobacteria 28216|Betaproteobacteria T Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - Guanylate_cyc,PEGA k59_487365_1 1198452.Jab_1c08300 2.81e-43 152.0 COG1660@1|root,COG1660@2|Bacteria,1MVX6@1224|Proteobacteria,2VIH5@28216|Betaproteobacteria,47677@75682|Oxalobacteraceae 28216|Betaproteobacteria S Displays ATPase and GTPase activities yhbJ - - ko:K06958 - - - - ko00000,ko03019 - - - ATP_bind_2 k59_1254761_1 522306.CAP2UW1_4250 2.11e-33 130.0 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,2WGNM@28216|Betaproteobacteria 28216|Betaproteobacteria K Transcriptional regulator - - - - - - - - - - - - Sigma54_activat k59_1212066_1 1123517.JOMR01000001_gene1030 6.63e-41 145.0 COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,1RN36@1236|Gammaproteobacteria,46018@72273|Thiotrichales 72273|Thiotrichales S Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates surE - 3.1.3.5 ko:K03787 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - SurE k59_1296400_1 1037409.BJ6T_65110 3.43e-24 100.0 COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S ABC transporter substrate binding protein - - - ko:K01989 - M00247 - - ko00000,ko00002,ko02000 - - - ABC_sub_bind k59_956159_2 760117.JN27_12600 3.76e-49 159.0 COG0745@1|root,COG0745@2|Bacteria,1RHDD@1224|Proteobacteria,2VSDT@28216|Betaproteobacteria,47497@75682|Oxalobacteraceae 28216|Betaproteobacteria KT cheY-homologous receiver domain cheY2 - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg k59_570487_1 1333998.M2A_0354 1.16e-68 231.0 COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,2TQQ8@28211|Alphaproteobacteria,4BPPH@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria M Transglycosylase pbpC - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase k59_321121_1 1246995.AFR_19605 5.1e-55 187.0 COG0277@1|root,COG0277@2|Bacteria,2GJ2T@201174|Actinobacteria,4DBYC@85008|Micromonosporales 201174|Actinobacteria C FAD linked oxidases, C-terminal domain glcD - 1.1.3.15 ko:K00104 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_1169443_1 1041159.AZUW01000007_gene5303 3.67e-31 120.0 COG0845@1|root,COG0845@2|Bacteria,1Q10W@1224|Proteobacteria,2TSC8@28211|Alphaproteobacteria,4BEXG@82115|Rhizobiaceae 28211|Alphaproteobacteria M HlyD family secretion protein - - - ko:K02005 - - - - ko00000 - - - HlyD_3 k59_209539_2 1410620.SHLA_25c000590 1.79e-30 119.0 COG0129@1|root,COG0129@2|Bacteria,1MV4I@1224|Proteobacteria,2TQRW@28211|Alphaproteobacteria,4B9NE@82115|Rhizobiaceae 28211|Alphaproteobacteria EG Dehydratase family - - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_679307_1 37919.EP51_25255 5.79e-24 107.0 COG0515@1|root,COG2197@1|root,COG3903@1|root,COG0515@2|Bacteria,COG2197@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,4G6JQ@85025|Nocardiaceae 201174|Actinobacteria K Protein tyrosine kinase - - 2.7.11.1 ko:K08282 - - - - ko00000,ko01000 - - - AAA_22,GerE,NB-ARC,Pkinase,TPR_12 k59_721320_2 1218084.BBJK01000023_gene2333 2.63e-10 60.8 COG3710@1|root,COG3710@2|Bacteria 2|Bacteria K Transcriptional regulator hemD - 2.7.11.1,4.2.1.75 ko:K01719,ko:K08282 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03165 RC01861 ko00000,ko00001,ko00002,ko01000 - - - HEM4,Trans_reg_C k59_1318176_1 1231391.AMZF01000014_gene2462 4.88e-38 137.0 COG0583@1|root,COG0583@2|Bacteria,1MVA1@1224|Proteobacteria,2VIBJ@28216|Betaproteobacteria,3T1ZW@506|Alcaligenaceae 28216|Betaproteobacteria K Transcriptional regulator oxyR - - ko:K04761 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - HTH_1,LysR_substrate k59_1275680_1 402626.Rpic_1232 4.04e-196 552.0 COG2224@1|root,COG2224@2|Bacteria,1MWIF@1224|Proteobacteria,2VHWS@28216|Betaproteobacteria,1K38Q@119060|Burkholderiaceae 28216|Betaproteobacteria C Isocitrate lyase aceA - 4.1.3.1 ko:K01637 ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200 M00012 R00479 RC00311,RC00313 ko00000,ko00001,ko00002,ko01000 - - - ICL k59_252955_2 1380394.JADL01000023_gene65 1.62e-58 184.0 COG2030@1|root,COG2030@2|Bacteria,1MW4N@1224|Proteobacteria,2U7FW@28211|Alphaproteobacteria,2JSWW@204441|Rhodospirillales 204441|Rhodospirillales I MaoC like domain - - - - - - - - - - - - MaoC_dehydratas k59_977008_2 344747.PM8797T_18946 1.82e-09 57.8 2BR4A@1|root,32K29@2|Bacteria,2J1BQ@203682|Planctomycetes 203682|Planctomycetes - - - - - - - - - - - - - - - k59_977011_1 292.DM42_2610 3.29e-62 194.0 COG2947@1|root,COG2947@2|Bacteria,1RHRU@1224|Proteobacteria,2VRIB@28216|Betaproteobacteria,1K4HB@119060|Burkholderiaceae 28216|Betaproteobacteria S EVE domain - - - - - - - - - - - - EVE k59_1142282_1 1158292.JPOE01000002_gene1667 1.2e-19 88.6 COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,2VJJH@28216|Betaproteobacteria,1KKP0@119065|unclassified Burkholderiales 28216|Betaproteobacteria K LysR substrate binding domain rbcR - - ko:K21703 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate k59_1142282_2 1125973.JNLC01000014_gene2512 5.67e-194 548.0 COG1850@1|root,COG1850@2|Bacteria,1MWEB@1224|Proteobacteria,2TSJV@28211|Alphaproteobacteria,3JU4U@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria H RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site cbbL - 4.1.1.39 ko:K01601 ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200 M00165,M00166,M00532 R00024,R03140 RC00172,RC00859 ko00000,ko00001,ko00002,ko01000 - - - RuBisCO_large,RuBisCO_large_N k59_934806_1 314278.NB231_12109 9.3e-149 439.0 COG3387@1|root,COG3387@2|Bacteria,1MV08@1224|Proteobacteria,1RS4U@1236|Gammaproteobacteria,1WWJ9@135613|Chromatiales 135613|Chromatiales G Glycoside hydrolase 15-related - - - - - - - - - - - - Glyco_hydro_15 k59_423825_1 1234364.AMSF01000002_gene2314 2.59e-16 83.6 COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1S720@1236|Gammaproteobacteria,1X954@135614|Xanthomonadales 135614|Xanthomonadales K Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Trans_reg_C k59_721456_1 111780.Sta7437_3257 7.57e-17 83.2 COG0300@1|root,COG0300@2|Bacteria,1G2GZ@1117|Cyanobacteria,3VKBZ@52604|Pleurocapsales 1117|Cyanobacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_122634_1 323848.Nmul_A2734 2.96e-26 100.0 COG0669@1|root,COG0669@2|Bacteria,1RD9F@1224|Proteobacteria,2VMQQ@28216|Betaproteobacteria,37305@32003|Nitrosomonadales 28216|Betaproteobacteria F Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate coaD - 2.7.7.3 ko:K00954 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_465877_1 426114.THI_1815 4.93e-132 387.0 COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,2VHYE@28216|Betaproteobacteria,1KJNG@119065|unclassified Burkholderiales 28216|Betaproteobacteria H glutamine synthetase glnA GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016866,GO:0034022,GO:0042537,GO:0044237,GO:0050486,GO:0071704,GO:1901360 5.4.4.3,6.3.1.2 ko:K01915,ko:K20712 ko00220,ko00250,ko00627,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00627,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253,R06988,R09284 RC00010,RC01754,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_977106_1 987059.RBXJA2T_09197 8.52e-150 429.0 COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,2VIVV@28216|Betaproteobacteria,1KJGI@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family trxB - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_887103_1 52598.EE36_11214 3.22e-22 96.3 COG3386@1|root,COG3386@2|Bacteria,1MX7V@1224|Proteobacteria,2U1AZ@28211|Alphaproteobacteria,3ZXP6@60136|Sulfitobacter 28211|Alphaproteobacteria G Strictosidine synthase - - - ko:K02057,ko:K10440 ko02010,map02010 M00212,M00221 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - BPD_transp_2,SGL,Str_synth k59_887103_2 863365.XHC_4346 1.72e-43 147.0 COG0302@1|root,COG0302@2|Bacteria,1MY3N@1224|Proteobacteria,1RMQM@1236|Gammaproteobacteria,1X3YF@135614|Xanthomonadales 135614|Xanthomonadales F GTP cyclohydrolase folE GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 3.5.4.16 ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - GTP_cyclohydroI k59_591348_1 402777.KB235903_gene1684 6.04e-05 50.4 COG2114@1|root,COG2203@1|root,COG5002@1|root,COG2114@2|Bacteria,COG2203@2|Bacteria,COG5002@2|Bacteria,1G1PT@1117|Cyanobacteria,1H7NV@1150|Oscillatoriales 1117|Cyanobacteria T PFAM Adenylate and Guanylate cyclase catalytic domain - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - GAF,Guanylate_cyc,PAS,PAS_9 k59_550987_1 1244869.H261_08343 9.14e-60 196.0 COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,2TRUF@28211|Alphaproteobacteria,2JQTD@204441|Rhodospirillales 204441|Rhodospirillales K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons hrcA - - ko:K03705 - - - - ko00000,ko03000 - - - HrcA,HrcA_DNA-bdg k59_164895_1 292415.Tbd_2563 1.84e-54 183.0 COG0543@1|root,COG0633@1|root,COG0543@2|Bacteria,COG0633@2|Bacteria,1MV72@1224|Proteobacteria,2VI9K@28216|Betaproteobacteria,1KRC9@119069|Hydrogenophilales 119069|Hydrogenophilales CH Oxidoreductase FAD-binding domain - - 1.17.1.1 ko:K00523 ko00520,map00520 - R03391,R03392 RC00230 ko00000,ko00001,ko01000 - - - FAD_binding_6,Fer2,NAD_binding_1 k59_887120_1 153721.MYP_329 1.25e-31 124.0 COG1449@1|root,COG1449@2|Bacteria,4NFXW@976|Bacteroidetes,47P2J@768503|Cytophagia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 57 family amyA - 3.2.1.1 ko:K07405 ko00500,ko01100,map00500,map01100 - R02108,R02112,R11262 - ko00000,ko00001,ko01000 - GH57 - Glyco_hydro_57 k59_934915_2 1038859.AXAU01000015_gene937 4.73e-61 202.0 COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,3JVRF@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Tripartite tricarboxylate transporter TctA family - - - ko:K07793 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.80.1 - - TctA k59_253141_1 1198452.Jab_2c20850 6.73e-31 121.0 COG0318@1|root,COG0764@1|root,COG0318@2|Bacteria,COG0764@2|Bacteria,1MXPB@1224|Proteobacteria,2VIYA@28216|Betaproteobacteria,473M1@75682|Oxalobacteraceae 28216|Betaproteobacteria IQ AMP-binding enzyme - - - - - - - - - - - - AMP-binding,AMP-binding_C,FabA k59_253141_2 948106.AWZT01000005_gene4341 7.65e-64 214.0 COG1216@1|root,COG4261@1|root,COG1216@2|Bacteria,COG4261@2|Bacteria,1MVXJ@1224|Proteobacteria,2WH20@28216|Betaproteobacteria,1KIGT@119060|Burkholderiaceae 28216|Betaproteobacteria S Pfam Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2,Lip_A_acyltrans k59_1190553_1 550540.Fbal_0853 1.33e-52 176.0 COG0568@1|root,COG0568@2|Bacteria,1MUDI@1224|Proteobacteria,1RN8V@1236|Gammaproteobacteria 1236|Gammaproteobacteria K RNA polymerase sigma rpoS GO:0000988,GO:0000990,GO:0001000,GO:0001121,GO:0001123,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043175,GO:0043254,GO:0044087,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - ko:K03087 ko02026,ko05111,map02026,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_423955_1 420662.Mpe_A1408 1.99e-10 61.2 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,2VJJ1@28216|Betaproteobacteria,1KJHB@119065|unclassified Burkholderiales 28216|Betaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain nuoF - 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_51K,NADH_4Fe-4S,SLBB k59_423955_2 261292.Nit79A3_2929 5.73e-74 225.0 COG1905@1|root,COG1905@2|Bacteria,1MWS2@1224|Proteobacteria,2VQD9@28216|Betaproteobacteria,371SU@32003|Nitrosomonadales 28216|Betaproteobacteria C Thioredoxin-like [2Fe-2S] ferredoxin nuoE - 1.6.5.3 ko:K00334 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx k59_934962_1 1148.1653490 2.16e-34 126.0 COG3588@1|root,COG3588@2|Bacteria,1GIGU@1117|Cyanobacteria,1H6CK@1142|Synechocystis 1117|Cyanobacteria F Fructose-bisphosphate aldolase class-I - - 4.1.2.13 ko:K01623 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000,ko03036,ko04131,ko04147 - - - Glycolytic k59_721613_1 999547.KI421502_gene3835 3.5e-23 106.0 COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2TQY9@28211|Alphaproteobacteria,2819I@191028|Leisingera 28211|Alphaproteobacteria S Tripartite ATP-independent periplasmic transporter, DctM component - - - - - - - - - - - - DctM k59_887187_1 323848.Nmul_A1551 1.39e-141 412.0 COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,2VH9T@28216|Betaproteobacteria,372HP@32003|Nitrosomonadales 28216|Betaproteobacteria E homoserine dehydrogenase hom - 1.1.1.3 ko:K00003 ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00017,M00018 R01773,R01775 RC00087 ko00000,ko00001,ko00002,ko01000 - - - ACT,Homoserine_dh,NAD_binding_3 k59_887187_2 261292.Nit79A3_0841 1.49e-33 127.0 COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,2VHR6@28216|Betaproteobacteria,372MN@32003|Nitrosomonadales 28216|Betaproteobacteria E Threonine synthase thrC - 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - - PALP,Thr_synth_N k59_1190628_1 1131553.JIBI01000039_gene1952 1.32e-47 167.0 COG2270@1|root,COG2270@2|Bacteria,1MWXB@1224|Proteobacteria,2VKNE@28216|Betaproteobacteria,372VG@32003|Nitrosomonadales 28216|Betaproteobacteria S Vacuole effluxer Atg22 like - - - ko:K06902 ko04138,map04138 - - - ko00000,ko00001,ko02000,ko04131 2.A.1.24,9.A.15.1 - - ATG22 k59_679668_2 283942.IL2031 8.45e-05 46.2 COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,1RN4V@1236|Gammaproteobacteria,2QFH6@267893|Idiomarinaceae 1236|Gammaproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamB GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0008152,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0016491,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0042802,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0055114,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063 - ko:K17713 - - - - ko00000,ko02000 1.B.33.1 - - PQQ_2,PQQ_3 k59_210006_1 1535422.ND16A_1984 5.42e-43 156.0 COG0457@1|root,COG0457@2|Bacteria,1N0A9@1224|Proteobacteria,1RZSZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S COG0457 FOG TPR repeat - - - - - - - - - - - - - k59_466100_1 1177928.TH2_19474 1.5e-66 204.0 COG0096@1|root,COG0096@2|Bacteria,1RDG3@1224|Proteobacteria,2U6ZH@28211|Alphaproteobacteria,2JS56@204441|Rhodospirillales 204441|Rhodospirillales J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit rpsH - - ko:K02994 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S8 k59_466100_2 158190.SpiGrapes_2149 3.71e-05 46.2 COG0097@1|root,COG0097@2|Bacteria,2J7WB@203691|Spirochaetes 203691|Spirochaetes J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center rplF - - ko:K02933 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L6 k59_122873_1 1288494.EBAPG3_8800 9e-104 324.0 COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,2VI8I@28216|Betaproteobacteria,371ZZ@32003|Nitrosomonadales 28216|Betaproteobacteria CO Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps dsbD - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - DsbC,DsbD,Thioredoxin_2,Thioredoxin_7 k59_424081_1 331869.BAL199_19216 5.09e-66 217.0 COG0318@1|root,COG0318@2|Bacteria,1MUMC@1224|Proteobacteria,2TR96@28211|Alphaproteobacteria,4BP9G@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria IQ AMP-binding enzyme C-terminal domain MA20_29420 - 6.2.1.48 ko:K00666,ko:K02182 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_424081_2 1288494.EBAPG3_200 2.81e-40 138.0 COG3448@1|root,COG3448@2|Bacteria,1PW0P@1224|Proteobacteria,2WBMR@28216|Betaproteobacteria,373ER@32003|Nitrosomonadales 28216|Betaproteobacteria T HPP family - - - - - - - - - - - - HPP k59_293197_1 483219.LILAB_23070 2.57e-84 267.0 COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,42MWZ@68525|delta/epsilon subdivisions,2WJ2B@28221|Deltaproteobacteria,2YX6I@29|Myxococcales 28221|Deltaproteobacteria J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 k59_977407_1 1123060.JONP01000012_gene2779 3.51e-70 233.0 COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,2TSAP@28211|Alphaproteobacteria,2JRAB@204441|Rhodospirillales 204441|Rhodospirillales C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.7.2.3 ko:K07812,ko:K08351 ko00780,ko01100,map00780,map01100 - R10127 RC03056 ko00000,ko00001,ko01000,ko02000 5.A.3.4 - - Molybdopterin,Molydop_binding,TAT_signal k59_293308_1 556268.OFAG_01273 2.14e-42 147.0 COG0639@1|root,COG0639@2|Bacteria,1MV10@1224|Proteobacteria,2VHV6@28216|Betaproteobacteria,472UW@75682|Oxalobacteraceae 28216|Betaproteobacteria T Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP apaH - 3.6.1.41 ko:K01525 ko00230,map00230 - R00125 RC00002 ko00000,ko00001,ko01000 - - - Metallophos k59_514394_1 391615.ABSJ01000005_gene583 3.15e-71 223.0 COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,1RNME@1236|Gammaproteobacteria,1J4DJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Inositol monophosphatase suhB - 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P k59_87966_1 314265.R2601_03953 2.56e-35 131.0 COG0824@1|root,COG0824@2|Bacteria 2|Bacteria IQ Thioesterase ybgC - - ko:K07107 - - - - ko00000,ko01000 - - - 4HBT,4HBT_2 k59_812440_1 1123393.KB891329_gene990 5.63e-115 333.0 COG0740@1|root,COG0740@2|Bacteria,1MV46@1224|Proteobacteria,2VHAZ@28216|Betaproteobacteria,1KRDV@119069|Hydrogenophilales 119069|Hydrogenophilales OU Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins clpP - 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease k59_812440_2 1198452.Jab_2c05890 4.96e-62 202.0 COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,2VIEU@28216|Betaproteobacteria,4729D@75682|Oxalobacteraceae 28216|Betaproteobacteria O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP clpX - - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX k59_344105_1 745014.OMB55_00022380 2.26e-96 304.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1J53A@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance spoT GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009259,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0015949,GO:0015969,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0019637,GO:0019693,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0033865,GO:0033875,GO:0034032,GO:0034035,GO:0034641,GO:0042278,GO:0042578,GO:0042594,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0071944,GO:0072521,GO:1901068,GO:1901135,GO:1901360,GO:1901564,GO:1901657 2.7.6.5,3.1.7.2 ko:K00951,ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - iECNA114_1301.ECNA114_3794,iECOK1_1307.ECOK1_4092,iECP_1309.ECP_3748,iECS88_1305.ECS88_4065,iECSF_1327.ECSF_3486,iLF82_1304.LF82_2165,iNRG857_1313.NRG857_18145,iUMN146_1321.UM146_18405,iUTI89_1310.UTI89_C4195,ic_1306.c4475 ACT_4,HD_4,RelA_SpoT,TGS k59_1196422_1 402881.Plav_3616 7.82e-51 171.0 COG0204@1|root,COG0204@2|Bacteria,1N2DG@1224|Proteobacteria,2TT8Q@28211|Alphaproteobacteria,1JNWR@119043|Rhodobiaceae 28211|Alphaproteobacteria I Phosphate acyltransferases plsC - 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_1239072_1 1123367.C666_02505 8.61e-181 529.0 COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,2VHTX@28216|Betaproteobacteria,2KV13@206389|Rhodocyclales 206389|Rhodocyclales M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamA - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_600457_2 153948.NAL212_0241 5.72e-122 358.0 COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,2VHIW@28216|Betaproteobacteria,3723I@32003|Nitrosomonadales 28216|Betaproteobacteria F Cell wall formation ddl - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C,Dala_Dala_lig_N k59_600457_3 693986.MOC_2781 1.44e-10 61.6 COG0812@1|root,COG0812@2|Bacteria,1MXDH@1224|Proteobacteria,2TRQR@28211|Alphaproteobacteria,1JTAT@119045|Methylobacteriaceae 28211|Alphaproteobacteria M Cell wall formation murB - 1.3.1.98 ko:K00075 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R03191,R03192 RC02639 ko00000,ko00001,ko01000,ko01011 - - - FAD_binding_4,MurB_C k59_727580_1 570967.JMLV01000001_gene2760 9.03e-74 233.0 COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,2TS1P@28211|Alphaproteobacteria,2JQF3@204441|Rhodospirillales 204441|Rhodospirillales M Belongs to the peptidase S11 family dacA - 3.4.16.4 ko:K07258 ko00550,ko01100,map00550,map01100 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - PBP5_C,Peptidase_S11 k59_3797_1 378806.STAUR_6743 2.51e-43 153.0 COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,42Z9B@68525|delta/epsilon subdivisions,2WMPJ@28221|Deltaproteobacteria,2YTYW@29|Myxococcales 28221|Deltaproteobacteria S Belongs to the pirin family - - - ko:K06911 - - - - ko00000 - - - Pirin,Pirin_C k59_258518_1 1454004.AW11_04012 1.43e-51 170.0 COG0560@1|root,COG0560@2|Bacteria,1RA1A@1224|Proteobacteria,2VMGV@28216|Betaproteobacteria,1KQNB@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria E haloacid dehalogenase-like hydrolase - - - - - - - - - - - - HAD k59_258518_2 760117.JN27_18190 2.74e-40 144.0 COG0593@1|root,COG0593@2|Bacteria,1MVW6@1224|Proteobacteria,2VSFD@28216|Betaproteobacteria,47250@75682|Oxalobacteraceae 28216|Betaproteobacteria L Belongs to the DnaA family hda - - ko:K10763 - - - - ko00000,ko03032 - - - Bac_DnaA k59_258518_3 395494.Galf_0603 5.47e-60 196.0 COG0628@1|root,COG0628@2|Bacteria,1MW0B@1224|Proteobacteria,2VHDW@28216|Betaproteobacteria,44WDZ@713636|Nitrosomonadales 28216|Betaproteobacteria S AI-2E family transporter perM - - - - - - - - - - - AI-2E_transport k59_1196514_1 930169.B5T_03966 3.37e-89 292.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1XHTM@135619|Oceanospirillales 135619|Oceanospirillales E Catalyzes the formation of glutamate from glutamine and alpha-ketoglutarate gltB - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_855211_1 420662.Mpe_A3769 1.57e-74 239.0 COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,2VHJ9@28216|Betaproteobacteria,1KIWK@119065|unclassified Burkholderiales 28216|Betaproteobacteria S modulator of DNA gyrase tldD - - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD k59_855211_2 640081.Dsui_3403 6.4e-08 53.9 COG3164@1|root,COG3164@2|Bacteria,1MXWF@1224|Proteobacteria,2VH52@28216|Betaproteobacteria,2KUGH@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function - - - - - - - - - - - - AsmA_2,DUF3971,DUF748 k59_471886_1 1279038.KB907337_gene264 6.02e-92 277.0 COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2TQK1@28211|Alphaproteobacteria,2JP9T@204441|Rhodospirillales 204441|Rhodospirillales E COG0411 ABC-type branched-chain amino acid transport systems, ATPase component - - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_685038_1 517722.AEUE01000008_gene58 8.87e-53 189.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria 28211|Alphaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_855224_2 1504672.669783771 7.37e-45 154.0 COG5662@1|root,COG5662@2|Bacteria,1RK1X@1224|Proteobacteria,2VQDP@28216|Betaproteobacteria,4ADKW@80864|Comamonadaceae 28216|Betaproteobacteria K transmembrane transcriptional prtR - - - - - - - - - - - zf-HC2 k59_898140_1 938709.AUSH02000054_gene1913 2.01e-15 73.6 COG0049@1|root,COG0049@2|Bacteria,4NEEM@976|Bacteroidetes 976|Bacteroidetes J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA rpsG GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02992 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S7 k59_898140_2 1121957.ATVL01000006_gene2857 2.07e-65 201.0 COG0048@1|root,COG0048@2|Bacteria,4NM3Y@976|Bacteroidetes,47PCE@768503|Cytophagia 976|Bacteroidetes J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit rpsL GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02950 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosom_S12_S23 k59_344282_1 264198.Reut_A0685 8.59e-80 253.0 COG2864@1|root,COG2864@2|Bacteria,1MXFQ@1224|Proteobacteria,2VKTA@28216|Betaproteobacteria,1K1V2@119060|Burkholderiaceae 28216|Betaproteobacteria C formate dehydrogenase fdhC - - ko:K00127 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001 - - - Ni_hydr_CYTB k59_344282_2 497321.C664_18524 7.86e-14 67.4 2E8DM@1|root,332S3@2|Bacteria,1ND1I@1224|Proteobacteria,2VX0K@28216|Betaproteobacteria,2KX9Z@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_344282_3 420662.Mpe_A1171 6e-66 205.0 COG0437@1|root,COG0437@2|Bacteria,1MU5T@1224|Proteobacteria,2VJXP@28216|Betaproteobacteria,1KKF1@119065|unclassified Burkholderiales 28216|Betaproteobacteria C 4Fe-4S dicluster domain fdhB - - ko:K00124,ko:K07307 ko00630,ko00680,ko00920,ko01100,ko01120,ko01200,map00630,map00680,map00920,map01100,map01120,map01200 - R00519,R09501 RC02555,RC02796 ko00000,ko00001,ko02000 5.A.3.3 - - Fer4_11,Fer4_7 k59_88114_1 1121007.AUML01000033_gene2794 8.83e-81 255.0 COG0603@1|root,COG0603@2|Bacteria,4NM2T@976|Bacteroidetes,1I8FT@117743|Flavobacteriia 976|Bacteroidetes F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) - - - - - - - - - - - - - k59_3959_1 243233.MCA2131 5.8e-85 278.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1XDW6@135618|Methylococcales 135618|Methylococcales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_1069510_1 323097.Nham_1939 1.43e-135 394.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,3JVIU@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_1154011_1 977880.RALTA_A3003 4.95e-37 127.0 COG0346@1|root,COG0346@2|Bacteria,1RHD4@1224|Proteobacteria,2VSJM@28216|Betaproteobacteria,1K7MX@119060|Burkholderiaceae 28216|Betaproteobacteria E PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - ko:K08234 - - - - ko00000 - - - Glyoxalase k59_1267322_1 488538.SAR116_2382 2.22e-49 163.0 COG0244@1|root,COG0244@2|Bacteria,1RAN5@1224|Proteobacteria,2U592@28211|Alphaproteobacteria,4BQP4@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors rplJ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02864 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L10 k59_284469_2 1101190.ARWB01000001_gene3700 4.48e-40 137.0 COG4113@1|root,COG4113@2|Bacteria,1N96B@1224|Proteobacteria,2UDE1@28211|Alphaproteobacteria,370F3@31993|Methylocystaceae 28211|Alphaproteobacteria S PIN domain - - - - - - - - - - - - PIN k59_284469_3 1120963.KB894491_gene1079 8.18e-15 73.2 COG0179@1|root,COG0179@2|Bacteria,1MV0V@1224|Proteobacteria,1RNYV@1236|Gammaproteobacteria,2Q47D@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria Q Fumarylacetoacetate (FAA) hydrolase family uptA - 3.7.1.2 ko:K16171 ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120 M00044 R01364 RC00326,RC00446 ko00000,ko00001,ko00002,ko01000 - - - FAA_hydrolase k59_582834_1 1244869.H261_03963 1.26e-08 58.9 2DP0X@1|root,3302S@2|Bacteria,1RIRD@1224|Proteobacteria,2UA7P@28211|Alphaproteobacteria,2JU7H@204441|Rhodospirillales 204441|Rhodospirillales S Protein of unknown function (DUF3306) - - - - - - - - - - - - DUF3306 k59_201429_1 744980.TRICHSKD4_5495 6.38e-17 75.9 COG1380@1|root,COG1380@2|Bacteria,1N753@1224|Proteobacteria,2UFFT@28211|Alphaproteobacteria 28211|Alphaproteobacteria S effector of murein hydrolase LrgA lrgA - - ko:K06518 - - - - ko00000,ko02000 1.E.14.2 - - LrgA k59_201429_2 398527.Bphyt_5345 2.28e-39 138.0 COG1346@1|root,COG1346@2|Bacteria,1MV81@1224|Proteobacteria,2VH4N@28216|Betaproteobacteria,1K2SA@119060|Burkholderiaceae 28216|Betaproteobacteria M PFAM LrgB family protein lrgB - - - - - - - - - - - LrgB k59_78168_1 998674.ATTE01000001_gene409 1.41e-44 155.0 COG2197@1|root,COG2197@2|Bacteria,1R2TM@1224|Proteobacteria,1S8D3@1236|Gammaproteobacteria 1236|Gammaproteobacteria T COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - - - - - - - - - - GerE,Response_reg k59_1182054_1 1173022.Cri9333_1229 7.14e-05 50.8 COG2203@1|root,COG4251@1|root,COG2203@2|Bacteria,COG4251@2|Bacteria,1G35U@1117|Cyanobacteria,1H78M@1150|Oscillatoriales 1117|Cyanobacteria T Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor domain - - - - - - - - - - - - CHASE3,DUF4118,GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg k59_582858_2 1121861.KB899917_gene3596 2.15e-74 232.0 COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,2TQKB@28211|Alphaproteobacteria,2JPJ9@204441|Rhodospirillales 204441|Rhodospirillales C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit sucD - 6.2.1.5 ko:K01902 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - CoA_binding,Ligase_CoA k59_1011115_1 317619.ANKN01000046_gene1052 3.09e-29 116.0 COG1723@1|root,COG1723@2|Bacteria,1G40I@1117|Cyanobacteria 1117|Cyanobacteria S PFAM Uncharacterised ACR, YagE family COG1723 - - - - - - - - - - - - DUF155 k59_332893_1 189753.AXAS01000008_gene6637 5.16e-167 473.0 COG3391@1|root,COG3391@2|Bacteria,1NT97@1224|Proteobacteria,2TWGD@28211|Alphaproteobacteria,3JQU4@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P NHL repeat MA20_20600 - - - - - - - - - - - NHL k59_1060881_1 1504672.669785151 2.31e-34 127.0 COG0656@1|root,COG0656@2|Bacteria,1MX6S@1224|Proteobacteria,2VNCV@28216|Betaproteobacteria,4AGTV@80864|Comamonadaceae 28216|Betaproteobacteria S Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red k59_1060881_2 331869.BAL199_05179 1.94e-24 99.4 28JPA@1|root,2Z9FC@2|Bacteria,1PN1F@1224|Proteobacteria,2TSKX@28211|Alphaproteobacteria,4BS51@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_284564_1 391625.PPSIR1_28023 9.99e-63 204.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,42Q0C@68525|delta/epsilon subdivisions,2WIIZ@28221|Deltaproteobacteria,2Z30M@29|Myxococcales 28221|Deltaproteobacteria L COG3344 Retron-type reverse transcriptase - - 2.7.7.49 ko:K00986,ko:K15342 - - - - ko00000,ko01000,ko02048,ko03400 - - - Cas_Cas1,GIIM,RVT_1 k59_201497_1 318996.AXAZ01000001_gene4789 6.07e-67 226.0 COG2203@1|root,COG4191@1|root,COG5002@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,COG5002@2|Bacteria,1RCM9@1224|Proteobacteria,2TTJ0@28211|Alphaproteobacteria,3K6MV@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Cache domain - - - - - - - - - - - - GAF,GAF_2,HAMP,HATPase_c,HisKA,dCache_1 k59_713185_1 948106.AWZT01000003_gene5914 1.05e-32 123.0 COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,2VI13@28216|Betaproteobacteria,1K0VA@119060|Burkholderiaceae 28216|Betaproteobacteria NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR cheB - 3.1.1.61,3.5.1.44 ko:K03412 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,Response_reg k59_879876_1 333138.LQ50_14315 1.38e-71 226.0 COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,4H9YB@91061|Bacilli,1ZBA4@1386|Bacillus 91061|Bacilli E Belongs to the ABC transporter superfamily appF GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K02032,ko:K10823 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - ABC_tran,oligo_HPY k59_457552_1 572477.Alvin_0044 2.02e-85 266.0 COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,1RP4V@1236|Gammaproteobacteria,1WVYR@135613|Chromatiales 135613|Chromatiales C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_1011225_1 331869.BAL199_18108 1.05e-61 213.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2TTBF@28211|Alphaproteobacteria,4BP6T@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015627,GO:0015628,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:0098776,GO:1901265,GO:1901363,GO:1904680 - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_78323_2 1523503.JPMY01000010_gene2611 1.55e-52 175.0 COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,1RMKP@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs truB GO:0000049,GO:0001522,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0031119,GO:0034337,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990481 5.4.99.25 ko:K03177 - - - - ko00000,ko01000,ko03016 - - - TruB-C_2,TruB_C_2,TruB_N k59_284675_1 1051985.l11_15330 1.22e-21 91.3 COG0801@1|root,COG0801@2|Bacteria,1MZH8@1224|Proteobacteria,2VSE2@28216|Betaproteobacteria,2KRBB@206351|Neisseriales 206351|Neisseriales H 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK - 2.7.6.3 ko:K00950 ko00790,ko01100,map00790,map01100 M00126,M00841 R03503 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - HPPK k59_284675_2 279714.FuraDRAFT_2258 3.69e-14 72.0 COG1428@1|root,COG1428@2|Bacteria,1RC50@1224|Proteobacteria,2VQ8U@28216|Betaproteobacteria,2KR9X@206351|Neisseriales 206351|Neisseriales F deoxyguanosine kinase K00904 dgk - - - - - - - - - - - dNK k59_802536_1 1469245.JFBG01000027_gene1470 3.09e-53 184.0 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria 1224|Proteobacteria E ABC-Type Dipeptide Transport System Periplasmic Component - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_755871_1 94624.Bpet2641 9.91e-109 320.0 COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,2VIM9@28216|Betaproteobacteria,3T1N5@506|Alcaligenaceae 28216|Betaproteobacteria J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily pheS - 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Phe_tRNA-synt_N,tRNA-synt_2d k59_755871_2 948106.AWZT01000009_gene2775 1.5e-56 197.0 COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1MWKS@1224|Proteobacteria,2VHR1@28216|Betaproteobacteria,1K1SA@119060|Burkholderiaceae 28216|Betaproteobacteria J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily pheT - 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5,FDX-ACB,tRNA_bind k59_114383_1 469610.HMPREF0189_00036 3.11e-106 320.0 COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,2VHQU@28216|Betaproteobacteria,1KJ5T@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_634513_2 1159870.KB907784_gene162 3.81e-22 91.7 COG0245@1|root,COG0245@2|Bacteria,1MVHA@1224|Proteobacteria,2VR7F@28216|Betaproteobacteria,3T3SA@506|Alcaligenaceae 28216|Betaproteobacteria I Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) ispF - 2.7.7.60,4.6.1.12 ko:K01770,ko:K12506 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05633,R05637 RC00002,RC01440 ko00000,ko00001,ko00002,ko01000 - - - YgbB k59_156711_2 345341.KUTG_03999 5.16e-10 61.6 COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,4E0IZ@85010|Pseudonocardiales 201174|Actinobacteria K Bacterial transcriptional activator domain - - - - - - - - - - - - AAA_22,BTAD,HTH_31,NB-ARC,TPR_12,Trans_reg_C k59_1061162_1 1000565.METUNv1_03995 8.66e-147 426.0 COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,2VHJ9@28216|Betaproteobacteria,2KUU8@206389|Rhodocyclales 206389|Rhodocyclales S modulator of DNA gyrase tldD - - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD k59_1061162_2 1123072.AUDH01000001_gene2906 6.6e-17 79.3 COG1788@1|root,COG1788@2|Bacteria,1NGS5@1224|Proteobacteria,2TVMU@28211|Alphaproteobacteria,2JU2U@204441|Rhodospirillales 204441|Rhodospirillales I COG1788 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit - - 2.8.3.12 ko:K01039 ko00643,ko00650,ko01120,map00643,map00650,map01120 - R04000,R05509 RC00012,RC00131,RC00137 ko00000,ko00001,ko01000 - - - CoA_trans k59_1061173_2 1100720.ALKN01000052_gene507 5.56e-33 125.0 COG2271@1|root,COG2271@2|Bacteria,1QTW2@1224|Proteobacteria 1224|Proteobacteria G Major facilitator Superfamily MA20_02120 - - - - - - - - - - - MFS_1 k59_1310230_1 402881.Plav_0935 1.96e-91 280.0 COG1804@1|root,COG1804@2|Bacteria,1PJ8T@1224|Proteobacteria,2V8SH@28211|Alphaproteobacteria,1JQ3K@119043|Rhodobiaceae 28211|Alphaproteobacteria C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_500270_1 96561.Dole_1488 5.23e-49 167.0 COG3640@1|root,COG3640@2|Bacteria,1R819@1224|Proteobacteria,42PQR@68525|delta/epsilon subdivisions,2WKE4@28221|Deltaproteobacteria,2MIKC@213118|Desulfobacterales 28221|Deltaproteobacteria D PFAM Cobyrinic acid ac-diamide synthase - - - ko:K07321 - - - - ko00000 - - - CbiA k59_713413_1 1245469.S58_69210 3.78e-167 478.0 COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2TSA7@28211|Alphaproteobacteria,3JTRC@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_504517_1 1408424.JHYI01000058_gene1560 1.12e-49 171.0 COG3547@1|root,COG3547@2|Bacteria,1V427@1239|Firmicutes,4HGY6@91061|Bacilli,1ZERT@1386|Bacillus 91061|Bacilli L PFAM transposase IS116 IS110 IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_37882_1 999541.bgla_1g04460 6.57e-112 338.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2VHES@28216|Betaproteobacteria,1K1SY@119060|Burkholderiaceae 28216|Betaproteobacteria S abc transporter yjjK - 3.6.3.25 ko:K06020 - - - - ko00000,ko01000 - - - ABC_tran,ABC_tran_Xtn k59_1271930_1 436308.Nmar_1753 2.11e-75 241.0 arCOG08764@1|root,arCOG08764@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_161002_1 1411123.JQNH01000001_gene145 1.12e-39 140.0 COG1175@1|root,COG1175@2|Bacteria,1MWB7@1224|Proteobacteria,2TUAN@28211|Alphaproteobacteria 28211|Alphaproteobacteria G ABC-type sugar transport systems permease components - - - ko:K02025 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 k59_161002_2 1038859.AXAU01000001_gene3889 4.17e-26 106.0 COG1653@1|root,COG1653@2|Bacteria,1MU64@1224|Proteobacteria,2TTUB@28211|Alphaproteobacteria,3JSQS@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria G Bacterial extracellular solute-binding protein - - - ko:K02027 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - SBP_bac_8,TAT_signal k59_289110_1 415426.Hbut_0441 8.54e-07 50.8 COG3276@1|root,arCOG01563@2157|Archaea,2XPP6@28889|Crenarchaeota 28889|Crenarchaeota J eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA eif2g - - ko:K03242 ko03013,map03013 - - - ko00000,ko00001,ko03012 - - - GTP_EFTU,GTP_EFTU_D2,eIF2_C k59_883776_1 580332.Slit_1699 7.4e-45 151.0 COG5501@1|root,COG5501@2|Bacteria,1RH4J@1224|Proteobacteria,2VT8I@28216|Betaproteobacteria 28216|Betaproteobacteria S sulfur oxidation protein SoxY soxY - - ko:K17226 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - SoxY k59_1272001_1 1380358.JADJ01000001_gene1087 6.71e-44 162.0 COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,1MUDP@1224|Proteobacteria,1RND3@1236|Gammaproteobacteria,1XH72@135619|Oceanospirillales 135619|Oceanospirillales E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvP - 1.4.4.2 ko:K00281,ko:K00283 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko00002,ko01000 - - - GDC-P k59_717730_1 1123504.JQKD01000018_gene1980 4.93e-21 88.6 COG0782@1|root,COG0782@2|Bacteria,1RAP0@1224|Proteobacteria,2VQ09@28216|Betaproteobacteria,4ABEW@80864|Comamonadaceae 28216|Betaproteobacteria K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length greB - - ko:K04760 - - - - ko00000,ko03021 - - - GreA_GreB,GreA_GreB_N k59_462091_1 1123504.JQKD01000007_gene3402 9.96e-56 184.0 COG0798@1|root,COG0798@2|Bacteria,1MUXY@1224|Proteobacteria,2VHWA@28216|Betaproteobacteria,4AA06@80864|Comamonadaceae 28216|Betaproteobacteria P PFAM Bile acid sodium symporter arsB - - ko:K03325 - - - - ko00000,ko02000 2.A.59 - - SBF k59_462091_2 365044.Pnap_2842 0.000884 41.6 COG2308@1|root,COG2308@2|Bacteria,1P9A0@1224|Proteobacteria,2VISX@28216|Betaproteobacteria,4ACKT@80864|Comamonadaceae 28216|Betaproteobacteria S Evidence 4 Homologs of previously reported genes of - - - - - - - - - - - - - k59_1015732_1 649349.Lbys_1456 8.06e-05 51.6 COG3385@1|root,COG3385@2|Bacteria,4P5DN@976|Bacteroidetes,47VRV@768503|Cytophagia 976|Bacteroidetes L DDE superfamily endonuclease - - - - - - - - - - - - DDE_5 k59_82826_1 1449976.KALB_8056 3.12e-32 117.0 COG0346@1|root,COG0346@2|Bacteria,2HZ9F@201174|Actinobacteria,4E7GG@85010|Pseudonocardiales 201174|Actinobacteria E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - - - - - - - - - - Glyoxalase,Glyoxalase_4 k59_82826_2 1230476.C207_02463 8.55e-57 191.0 COG4948@1|root,COG4948@2|Bacteria,1MV2S@1224|Proteobacteria,2TTFB@28211|Alphaproteobacteria,3JTFN@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M Mandelate Racemase Muconate Lactonizing - - - - - - - - - - - - MR_MLE_C k59_931091_1 1268622.AVS7_03116 5.66e-57 192.0 COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,2VJZN@28216|Betaproteobacteria,4A9YY@80864|Comamonadaceae 28216|Betaproteobacteria C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane pntA - 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N,PNTB_4TM k59_931091_2 946483.Cenrod_0944 5.51e-48 166.0 COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,2VIDR@28216|Betaproteobacteria,4AAKQ@80864|Comamonadaceae 28216|Betaproteobacteria C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane pntB - 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB k59_587557_1 640081.Dsui_1393 2.27e-137 405.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,2KUQA@206389|Rhodocyclales 206389|Rhodocyclales NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB - - - ko:K02454,ko:K02652 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSE,T2SSE_N k59_931119_1 1207063.P24_05279 7.5e-77 237.0 COG1173@1|root,COG1173@2|Bacteria,1MVER@1224|Proteobacteria,2TRB3@28211|Alphaproteobacteria,2JQ5D@204441|Rhodospirillales 204441|Rhodospirillales EP Binding-protein-dependent transport system inner membrane component - - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1,OppC_N k59_931119_2 285514.JNWO01000009_gene8760 1.32e-09 59.3 COG0444@1|root,COG0444@2|Bacteria,2GIXV@201174|Actinobacteria 201174|Actinobacteria EP Belongs to the ABC transporter superfamily - - - ko:K02031 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_420147_1 314264.ROS217_23920 1.56e-07 53.9 COG1853@1|root,COG1853@2|Bacteria,1MUPP@1224|Proteobacteria,2TT7S@28211|Alphaproteobacteria,46PS8@74030|Roseovarius 28211|Alphaproteobacteria S COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family - - - - - - - - - - - - Flavin_Reduct k59_289255_1 395495.Lcho_3893 4.6e-30 123.0 COG2132@1|root,COG2132@2|Bacteria,1N9H3@1224|Proteobacteria,2VZQA@28216|Betaproteobacteria,1KNDH@119065|unclassified Burkholderiales 28216|Betaproteobacteria Q Multicopper oxidase - - 1.16.3.3 ko:K22349 - - - - ko00000,ko01000 - - - - k59_973448_1 1123373.ATXI01000006_gene157 1.78e-71 229.0 COG0014@1|root,COG0014@2|Bacteria,2GH1U@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate proA - 1.2.1.41 ko:K00147 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 M00015 R03313 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_118963_1 1049564.TevJSym_ac00580 1.06e-60 208.0 COG2010@1|root,COG2010@2|Bacteria,1R28S@1224|Proteobacteria,1T5JD@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Cytochrome c - - - - - - - - - - - - Cytochrome_CBB3 k59_883945_1 999541.bgla_1g32670 5.66e-97 294.0 COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,2VIHD@28216|Betaproteobacteria,1K1BK@119060|Burkholderiaceae 28216|Betaproteobacteria D Tyrosine recombinase XerD xerD - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_883945_2 267608.RSc2545 1.35e-75 229.0 COG2606@1|root,COG2606@2|Bacteria,1RGX5@1224|Proteobacteria,2VQAY@28216|Betaproteobacteria,1K2NU@119060|Burkholderiaceae 28216|Betaproteobacteria S Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily ebsC - - ko:K03976 - - - - ko00000,ko01000,ko03016 - - - tRNA_edit k59_840757_1 882378.RBRH_03252 1.38e-76 241.0 COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,2VGZP@28216|Betaproteobacteria,1K1ZW@119060|Burkholderiaceae 28216|Betaproteobacteria D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring ftsA - - ko:K03590 ko04112,map04112 - - - ko00000,ko00001,ko03036,ko04812 - - - FtsA,SHS2_FTSA k59_1186941_1 1442599.JAAN01000014_gene3485 2.13e-136 403.0 COG1274@1|root,COG1274@2|Bacteria,1MX3C@1224|Proteobacteria,1RNGQ@1236|Gammaproteobacteria,1X482@135614|Xanthomonadales 135614|Xanthomonadales H Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle pckG - 4.1.1.32 ko:K01596 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964 M00003 R00431,R00726 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPCK_C,PEPCK_N k59_381014_1 2880.D7FW18 1.71e-29 119.0 2CY2I@1|root,2S1H1@2759|Eukaryota 2759|Eukaryota - - - - - - - - - - - - - - Ank_5 k59_1186948_1 321327.CYA_2851 4.78e-23 97.1 COG0668@1|root,COG0668@2|Bacteria,1G08V@1117|Cyanobacteria,1GZQV@1129|Synechococcus 1117|Cyanobacteria M Mechanosensitive ion channel mscS - - - - - - - - - - - MS_channel k59_1186948_2 1307759.JOMJ01000003_gene894 3.38e-38 141.0 COG0380@1|root,COG0380@2|Bacteria,1MUIY@1224|Proteobacteria,42NBU@68525|delta/epsilon subdivisions,2WJX9@28221|Deltaproteobacteria,2MA96@213115|Desulfovibrionales 28221|Deltaproteobacteria G PFAM Glycosyl transferase, family 20 otsAB - 2.4.1.15,2.4.1.347,3.1.3.12 ko:K00697,ko:K16055 ko00500,ko01100,map00500,map01100 - R02737,R02778 RC00005,RC00017,RC00049,RC02748 ko00000,ko00001,ko01000,ko01003 - GT20 - Glyco_transf_20,S6PP,Trehalose_PPase k59_289406_1 314230.DSM3645_28047 2.32e-51 179.0 COG3385@1|root,COG3385@2|Bacteria,2IYW8@203682|Planctomycetes 203682|Planctomycetes L COG3385 FOG Transposase and inactivated derivatives - - - - - - - - - - - - DDE_Tnp_1 k59_1314786_1 697282.Mettu_0386 5.9e-73 239.0 COG1234@1|root,COG1341@1|root,COG1234@2|Bacteria,COG1341@2|Bacteria,1PPRD@1224|Proteobacteria,1RRV8@1236|Gammaproteobacteria,1XFJE@135618|Methylococcales 135618|Methylococcales S Beta-lactamase superfamily domain - - 3.1.26.11 ko:K00784 ko03013,map03013 - - - ko00000,ko00001,ko01000,ko03016 - - - Lactamase_B_2 k59_547440_1 521674.Plim_2520 1.89e-42 146.0 COG1225@1|root,COG1225@2|Bacteria,2IZYV@203682|Planctomycetes 203682|Planctomycetes O Redoxin - - - - - - - - - - - - Redoxin k59_760468_1 1121937.AUHJ01000007_gene1956 3.07e-77 241.0 2DBQY@1|root,2ZAHD@2|Bacteria,1QYTK@1224|Proteobacteria,1T3V2@1236|Gammaproteobacteria,46DA3@72275|Alteromonadaceae 1236|Gammaproteobacteria S Transposase zinc-binding domain - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_1314791_2 1000565.METUNv1_02254 9.21e-47 157.0 COG0244@1|root,COG0244@2|Bacteria,1RAN5@1224|Proteobacteria,2VQ7A@28216|Betaproteobacteria,2KW86@206389|Rhodocyclales 206389|Rhodocyclales J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors rplJ - - ko:K02864 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L10 k59_1186986_1 388413.ALPR1_17608 2.77e-18 85.5 COG1236@1|root,COG1236@2|Bacteria,4NESD@976|Bacteroidetes,47K9F@768503|Cytophagia 976|Bacteroidetes J exonuclease of the beta-lactamase fold involved in RNA processing - - - ko:K07576 - - - - ko00000 - - - Beta-Casp,Lactamase_B,Lactamase_B_6,RMMBL k59_1186986_2 1123367.C666_01840 3.69e-52 172.0 COG0664@1|root,COG0664@2|Bacteria,1R6BV@1224|Proteobacteria,2VN3A@28216|Betaproteobacteria,2KVAG@206389|Rhodocyclales 206389|Rhodocyclales K COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases nnr - - ko:K01420 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding k59_973601_1 1458275.AZ34_06180 6.47e-49 174.0 COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,2VHJV@28216|Betaproteobacteria,4A9KF@80864|Comamonadaceae 28216|Betaproteobacteria D PFAM cell divisionFtsK SpoIIIE ftsK - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma k59_795908_1 558169.AGAV01000016_gene972 1.58e-42 150.0 COG0216@1|root,COG0216@2|Bacteria,1TQ7V@1239|Firmicutes,4H9MB@91061|Bacilli 91061|Bacilli J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_795908_2 382464.ABSI01000022_gene490 8.17e-10 60.5 COG2890@1|root,COG2890@2|Bacteria,46SZE@74201|Verrucomicrobia,2IU5P@203494|Verrucomicrobiae 203494|Verrucomicrobiae J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif prmC - 2.1.1.297 ko:K02493 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03012 - - - MTS k59_194987_1 189753.AXAS01000020_gene1631 3.21e-49 174.0 COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,2TS0E@28211|Alphaproteobacteria,3JSSV@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria H Catalyzes the oxidation of L-aspartate to iminoaspartate nadB - 1.4.3.16 ko:K00278 ko00250,ko00760,ko01100,map00250,map00760,map01100 M00115 R00357,R00481 RC00006,RC02566 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_408245_1 1027273.GZ77_22335 2.16e-54 182.0 COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,1RNJ1@1236|Gammaproteobacteria,1XJ29@135619|Oceanospirillales 135619|Oceanospirillales P transporter, permease oppB - - ko:K02033,ko:K15581 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - BPD_transp_1 k59_831050_1 1123256.KB907928_gene2204 1.51e-27 104.0 COG1734@1|root,COG1734@2|Bacteria,1NH80@1224|Proteobacteria,1SAW8@1236|Gammaproteobacteria 1236|Gammaproteobacteria T dksA traR - - - - - - - - - - - - zf-dskA_traR k59_831050_2 1123393.KB891326_gene76 2.84e-42 151.0 COG1488@1|root,COG1488@2|Bacteria,1PNWY@1224|Proteobacteria,2W9DN@28216|Betaproteobacteria,1KS4Z@119069|Hydrogenophilales 119069|Hydrogenophilales H Nicotinate phosphoribosyltransferase (NAPRTase) family - - - - - - - - - - - - NAPRTase k59_1095507_1 1408164.MOLA814_00005 4.25e-42 143.0 COG1845@1|root,COG1845@2|Bacteria,1MXAB@1224|Proteobacteria,2VRZP@28216|Betaproteobacteria 28216|Betaproteobacteria C Cytochrome c oxidase subunit III coxO - 1.9.3.1 ko:K02276 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.4,3.D.4.6 - - COX3 k59_1095507_2 936455.KI421499_gene3590 1.64e-31 116.0 COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,2U0NA@28211|Alphaproteobacteria,3JUYG@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Cytochrome c oxidase subunit III coxP - 1.9.3.1 ko:K02276,ko:K02299 ko00190,ko01100,map00190,map01100 M00155,M00417 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.4,3.D.4.5,3.D.4.6 - - COX3 k59_706644_1 305900.GV64_13440 3.51e-19 84.7 COG0565@1|root,COG0565@2|Bacteria,1N47Y@1224|Proteobacteria,1RPD3@1236|Gammaproteobacteria,1XH6W@135619|Oceanospirillales 135619|Oceanospirillales J Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA - - 2.1.1.200 ko:K15396 - - - - ko00000,ko01000,ko03016 - - - SpoU_methylase k59_706644_2 1123487.KB892840_gene21 2.21e-32 120.0 COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,2VIXG@28216|Betaproteobacteria,2KVHM@206389|Rhodocyclales 206389|Rhodocyclales G COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family - - 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P k59_149960_1 1095769.CAHF01000011_gene2637 4.75e-88 279.0 COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,2VH19@28216|Betaproteobacteria,4733B@75682|Oxalobacteraceae 28216|Betaproteobacteria J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG - 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1g,tRNA_bind k59_1302822_1 582744.Msip34_0906 2.26e-86 262.0 COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,2VH1U@28216|Betaproteobacteria,2KKX8@206350|Nitrosomonadales 206350|Nitrosomonadales C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit sucD - 6.2.1.5 ko:K01902 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - CoA_binding,Ligase_CoA k59_1218263_1 318586.Pden_0203 7.07e-54 181.0 COG2141@1|root,COG2141@2|Bacteria,1MX64@1224|Proteobacteria,2TV8M@28211|Alphaproteobacteria,2PXT9@265|Paracoccus 28211|Alphaproteobacteria C Luciferase-like monooxygenase limB - - - - - - - - - - - Bac_luciferase k59_663927_1 398525.KB900701_gene3628 5.38e-79 243.0 COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,2TRIH@28211|Alphaproteobacteria,3JRFJ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I Belongs to the enoyl-CoA hydratase isomerase family MA20_16365 - 4.2.1.149 ko:K08299 - - R10675 RC01095 ko00000,ko01000 - - - ECH_1 k59_1095563_1 314254.OA2633_05506 1.06e-28 110.0 COG0435@1|root,COG0435@2|Bacteria,1MV50@1224|Proteobacteria,2TRDE@28211|Alphaproteobacteria,43X7S@69657|Hyphomonadaceae 28211|Alphaproteobacteria O Glutathione S-transferase, C-terminal domain yqjG GO:0003674,GO:0003824,GO:0004364,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0016491,GO:0016667,GO:0016672,GO:0016740,GO:0016765,GO:0042221,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.8.5.7 ko:K07393 - - - - ko00000,ko01000 - - - GST_C_2,GST_N_2 k59_1095563_2 395961.Cyan7425_0831 5.31e-36 131.0 COG0614@1|root,COG0614@2|Bacteria,1G1W1@1117|Cyanobacteria,3KFRA@43988|Cyanothece 1117|Cyanobacteria P Periplasmic binding protein - - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 k59_706685_1 113395.AXAI01000011_gene6533 1.77e-19 92.0 COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S ABC transporter substrate binding protein - - - ko:K01989 - M00247 - - ko00000,ko00002,ko02000 - - - ABC_sub_bind k59_107636_1 1216976.AX27061_4805 7.73e-191 564.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,2VI4A@28216|Betaproteobacteria,3T1KP@506|Alcaligenaceae 28216|Betaproteobacteria F Four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_795983_1 1122164.JHWF01000015_gene1642 6.97e-25 106.0 COG1680@1|root,COG1680@2|Bacteria,1RIZ7@1224|Proteobacteria,1SZDG@1236|Gammaproteobacteria,1JDVX@118969|Legionellales 118969|Legionellales M Beta-lactamase - - - - - - - - - - - - Beta-lactamase k59_799946_1 1131553.JIBI01000071_gene2158 2.23e-101 310.0 COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,2VIH1@28216|Betaproteobacteria,3720Q@32003|Nitrosomonadales 28216|Betaproteobacteria C TrkA-N domain protein trkA - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N k59_1222339_1 395494.Galf_0288 1.06e-22 94.7 COG0352@1|root,COG0494@1|root,COG0352@2|Bacteria,COG0494@2|Bacteria,1RCZM@1224|Proteobacteria,2VHTP@28216|Betaproteobacteria,44V8D@713636|Nitrosomonadales 28216|Betaproteobacteria HL Thiamine monophosphate synthase mutT - 3.6.1.55 ko:K03574 - - - - ko00000,ko01000,ko03400 - - - NUDIX,TMP-TENI k59_1222339_2 522306.CAP2UW1_0259 1.09e-85 261.0 COG2607@1|root,COG2607@2|Bacteria,1MVMX@1224|Proteobacteria,2VID5@28216|Betaproteobacteria,1KPP1@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria S General function prediction only - - - ko:K06923 - - - - ko00000 - - - DUF815 k59_497516_1 1247963.JPHU01000005_gene254 8.18e-93 283.0 COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1MW7X@1224|Proteobacteria,2TTH8@28211|Alphaproteobacteria 28211|Alphaproteobacteria L COG3335 Transposase and inactivated derivatives - - - ko:K07494 - - - - ko00000 - - - DDE_3,HTH_29,HTH_32 k59_242119_1 1122929.KB908215_gene718 1.4e-127 371.0 COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,2TT50@28211|Alphaproteobacteria 28211|Alphaproteobacteria I COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases MA20_25935 - 1.1.1.31,1.1.1.60 ko:K00020,ko:K00042 ko00280,ko00630,ko01100,map00280,map00630,map01100 - R01745,R01747,R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_1264973_1 1248760.ANFZ01000009_gene1074 2.01e-12 68.2 COG1075@1|root,COG1075@2|Bacteria,1NJNA@1224|Proteobacteria,2TSQC@28211|Alphaproteobacteria,2K23V@204457|Sphingomonadales 204457|Sphingomonadales S Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_631383_1 1454004.AW11_02854 1.92e-73 236.0 COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,2VP1W@28216|Betaproteobacteria 28216|Betaproteobacteria CP Proton-conducting membrane transporter - - - - - - - - - - - - Proton_antipo_M k59_1264989_1 415426.Hbut_0885 8.13e-37 135.0 COG0024@1|root,arCOG01001@2157|Archaea,2XPVJ@28889|Crenarchaeota 28889|Crenarchaeota E Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) map - 3.4.11.18 ko:K01265 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 k59_1058016_1 78245.Xaut_4058 5.32e-81 253.0 COG0402@1|root,COG0402@2|Bacteria,1MX34@1224|Proteobacteria,2U0IN@28211|Alphaproteobacteria,3EY6B@335928|Xanthobacteraceae 28211|Alphaproteobacteria F Amidohydrolase family - - 3.5.4.1 ko:K01485 ko00240,ko00330,ko01100,map00240,map00330,map01100 - R00974,R01411,R02922 RC00074,RC00514,RC00809 ko00000,ko00001,ko01000 - - - Amidohydro_1,Amidohydro_3 k59_282114_1 381666.H16_B0450 3.09e-31 122.0 COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,2VI0E@28216|Betaproteobacteria,1K4KX@119060|Burkholderiaceae 28216|Betaproteobacteria L PFAM Integrase catalytic - - - - - - - - - - - - HTH_38,rve k59_1058029_1 1249627.D779_2949 1.92e-21 93.6 COG1394@1|root,COG1394@2|Bacteria,1RJ1P@1224|Proteobacteria,1S75D@1236|Gammaproteobacteria,1WYND@135613|Chromatiales 135613|Chromatiales C ATP synthase subunit D - - - ko:K02120 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - ATP-synt_D k59_1265010_1 265072.Mfla_2252 1.65e-79 255.0 COG0548@1|root,COG1246@1|root,COG1396@1|root,COG0548@2|Bacteria,COG1246@2|Bacteria,COG1396@2|Bacteria,1MUUP@1224|Proteobacteria,2VGZC@28216|Betaproteobacteria,2KKM3@206350|Nitrosomonadales 206350|Nitrosomonadales E Belongs to the acetyltransferase family. ArgA subfamily argA - 2.3.1.1 ko:K14682 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,Acetyltransf_1,HTH_31 k59_75845_1 1499686.BN1079_02543 2.03e-64 210.0 COG4324@1|root,COG4324@2|Bacteria,1N0FE@1224|Proteobacteria,1S0JM@1236|Gammaproteobacteria 1236|Gammaproteobacteria E aminopeptidase - - - - - - - - - - - - Aminopep k59_373824_1 1535422.ND16A_3571 5.14e-62 201.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,1RMAQ@1236|Gammaproteobacteria,2Q707@267889|Colwelliaceae 1236|Gammaproteobacteria L Transposase - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_966374_1 63737.Npun_F1592 5.9e-86 272.0 COG1282@1|root,COG1282@2|Bacteria,1G2AX@1117|Cyanobacteria,1HII6@1161|Nostocales 1117|Cyanobacteria C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane pntB - 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB k59_668603_1 1123360.thalar_02506 7.4e-81 248.0 COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,1PBHA@1224|Proteobacteria,2TRQF@28211|Alphaproteobacteria 28211|Alphaproteobacteria L COG2801 Transposase and inactivated derivatives - - - - - - - - - - - - HTH_32,rve k59_668603_2 1231190.NA8A_22031 1.5e-61 191.0 COG2963@1|root,COG2963@2|Bacteria,1RHKX@1224|Proteobacteria,2U9TV@28211|Alphaproteobacteria,43KIH@69277|Phyllobacteriaceae 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - HTH_Tnp_1 k59_540190_1 1293054.HSACCH_02488 7.36e-41 152.0 COG1757@1|root,COG1757@2|Bacteria,1TP8A@1239|Firmicutes,247V4@186801|Clostridia,3WA9C@53433|Halanaerobiales 186801|Clostridia C PFAM Na H antiporter - - - - - - - - - - - - Na_H_antiporter k59_710759_2 1469613.JT55_13450 2.49e-58 195.0 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,2TSCY@28211|Alphaproteobacteria,3FE8W@34008|Rhodovulum 28211|Alphaproteobacteria E Asparagine synthase asnB - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_455073_1 395494.Galf_1436 2.52e-82 265.0 COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,2VP2B@28216|Betaproteobacteria,44W71@713636|Nitrosomonadales 28216|Betaproteobacteria P ABC transporter transmembrane region - - - ko:K11004 ko02010,ko03070,ko05133,map02010,map03070,map05133 M00325,M00575 - - ko00000,ko00001,ko00002,ko02000,ko02044 3.A.1.109.1,3.A.1.109.2 - - ABC_membrane,ABC_tran k59_330361_1 1121406.JAEX01000015_gene619 1.07e-05 53.5 COG2972@1|root,COG4585@1|root,COG2972@2|Bacteria,COG4585@2|Bacteria,1MWPN@1224|Proteobacteria,42SJA@68525|delta/epsilon subdivisions,2WPP4@28221|Deltaproteobacteria,2MG1K@213115|Desulfovibrionales 28221|Deltaproteobacteria T Histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA_3,PAS,PAS_4,PAS_8,PAS_9,Response_reg k59_580518_1 1411123.JQNH01000001_gene2713 1.55e-108 332.0 COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2TQY9@28211|Alphaproteobacteria 28211|Alphaproteobacteria S transport system fused permease components - - - - - - - - - - - - DUF3394,DctM k59_75904_1 580332.Slit_1715 3.81e-122 365.0 COG1053@1|root,COG1053@2|Bacteria,1NZBR@1224|Proteobacteria,2VHJ5@28216|Betaproteobacteria,44WIW@713636|Nitrosomonadales 28216|Betaproteobacteria C Fumarate reductase flavoprotein C-term - - 1.8.99.2 ko:K00394 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00596 R00860,R04927,R08553 RC00007,RC01239,RC02862 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_1307509_1 394221.Mmar10_0677 3.04e-67 228.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,2TWVC@28211|Alphaproteobacteria,440R8@69657|Hyphomonadaceae 28211|Alphaproteobacteria S Sterol-sensing domain of SREBP cleavage-activation - - - ko:K07003 - - - - ko00000 - - - MMPL k59_1307531_1 640081.Dsui_1383 5.92e-104 322.0 COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2VHQQ@28216|Betaproteobacteria,2KUCM@206389|Rhodocyclales 206389|Rhodocyclales P Belongs to the monovalent cation proton antiporter 2 (cpa2) transporter (TC 2.A.37) family - - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger,TrkA_C,TrkA_N k59_154160_1 1429916.X566_14905 1.74e-43 149.0 COG0596@1|root,COG0596@2|Bacteria,1NUT9@1224|Proteobacteria,2TVMS@28211|Alphaproteobacteria,3JT3H@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Alpha/beta hydrolase family - - - - - - - - - - - - Abhydrolase_1 k59_154160_2 477184.KYC_08760 4.53e-20 86.3 COG3255@1|root,COG3255@2|Bacteria,1RG3A@1224|Proteobacteria,2VX1T@28216|Betaproteobacteria,3T80I@506|Alcaligenaceae 28216|Betaproteobacteria I Sterol carrier protein - - - - - - - - - - - - - k59_1222540_1 247490.KSU1_B0556 2.26e-47 164.0 COG0673@1|root,COG0673@2|Bacteria,2IXAX@203682|Planctomycetes 203682|Planctomycetes S Oxidoreductase domain protein - - - - - - - - - - - - GFO_IDH_MocA k59_497721_1 1198452.Jab_1c05970 7.58e-67 229.0 COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2VJGC@28216|Betaproteobacteria,472T4@75682|Oxalobacteraceae 28216|Betaproteobacteria C Pyruvate ferredoxin/flavodoxin oxidoreductase - - 1.2.7.8 ko:K04090 - - - - br01601,ko00000,ko01000 - - - POR,TPP_enzyme_C k59_413074_1 1123368.AUIS01000016_gene2546 8.09e-83 268.0 COG0457@1|root,COG4796@1|root,COG0457@2|Bacteria,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,1T5UQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria U Secretin and TonB N terminus short domain - - - - - - - - - - - - Secretin k59_1008905_2 1380394.JADL01000001_gene2865 6.19e-35 129.0 COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,2TQPN@28211|Alphaproteobacteria,2JPXN@204441|Rhodospirillales 204441|Rhodospirillales E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily hisC - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_111890_1 1044.EH31_12645 6.78e-55 191.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MWGR@1224|Proteobacteria,2TRTE@28211|Alphaproteobacteria,2K0PD@204457|Sphingomonadales 204457|Sphingomonadales EU Prolyl oligopeptidase family - - - - - - - - - - - - PD40,Peptidase_S9 k59_631633_1 85643.Tmz1t_0868 1.02e-82 252.0 COG4535@1|root,COG4535@2|Bacteria,1QTU8@1224|Proteobacteria,2VIU8@28216|Betaproteobacteria,2KV4Z@206389|Rhodocyclales 206389|Rhodocyclales P Mg2 and Co2 transporter CorC - - - ko:K06189 - - - - ko00000,ko02000 9.A.40.1.2 - - CBS,CorC_HlyC k59_455194_1 283165.BQ02200 4.58e-12 73.2 COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,2TRPB@28211|Alphaproteobacteria,48TBN@772|Bartonellaceae 28211|Alphaproteobacteria H DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity dnaX - 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNA_pol3_gamma3,DUF3646 k59_455194_2 1054213.HMPREF9946_02685 3.56e-35 123.0 COG0718@1|root,COG0718@2|Bacteria,1RGZD@1224|Proteobacteria,2UBQB@28211|Alphaproteobacteria,2JT9R@204441|Rhodospirillales 204441|Rhodospirillales S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection - - - ko:K09747 - - - - ko00000 - - - YbaB_DNA_bd k59_154275_1 395493.BegalDRAFT_0479 1.9e-40 143.0 2EMEM@1|root,33F3F@2|Bacteria,1NK08@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_924206_1 420324.KI911934_gene172 3.48e-65 208.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,1JXEF@119045|Methylobacteriaceae 28211|Alphaproteobacteria L Transposase - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_76049_1 1207063.P24_13673 5.75e-260 722.0 COG1053@1|root,COG1053@2|Bacteria,1MX5A@1224|Proteobacteria,2TV7T@28211|Alphaproteobacteria,2JQSB@204441|Rhodospirillales 204441|Rhodospirillales C FAD dependent oxidoreductase - - - - - - - - - - - - FAD_binding_2 k59_76049_2 1100721.ALKO01000017_gene1635 1.52e-15 75.5 COG1028@1|root,COG1028@2|Bacteria,1QWBB@1224|Proteobacteria,2W24M@28216|Betaproteobacteria,4AJ28@80864|Comamonadaceae 28216|Betaproteobacteria IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short_C2 k59_753542_1 994479.GL877882_gene6926 1.16e-18 88.2 COG1123@1|root,COG4172@2|Bacteria,2H3HY@201174|Actinobacteria,4DYQD@85010|Pseudonocardiales 201174|Actinobacteria P ATPases associated with a variety of cellular activities - - - ko:K02031,ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran k59_753542_2 869210.Marky_1517 2.24e-11 64.7 COG1732@1|root,COG1732@2|Bacteria,1WJ2C@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus M COGs COG1732 Periplasmic glycine betaine choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) - - - ko:K05845 ko02010,map02010 M00209 - - ko00000,ko00001,ko00002,ko02000 3.A.1.12 - - OpuAC k59_631745_1 305900.GV64_21950 2.85e-49 170.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,1XICI@135619|Oceanospirillales 135619|Oceanospirillales O Belongs to the peptidase S1C family - - 3.4.21.107 ko:K04691,ko:K04771,ko:K04772 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ,PDZ_2,Trypsin_2 k59_330630_1 1380391.JIAS01000006_gene2541 2.85e-71 226.0 COG0564@1|root,COG0564@2|Bacteria,1MVDX@1224|Proteobacteria,2TTQC@28211|Alphaproteobacteria,2JPRV@204441|Rhodospirillales 204441|Rhodospirillales J Responsible for synthesis of pseudouridine from uracil rluC - 5.4.99.24 ko:K06179 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_374096_1 439235.Dalk_5003 1.72e-08 55.5 COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,42Q40@68525|delta/epsilon subdivisions,2WKJ7@28221|Deltaproteobacteria,2MK6F@213118|Desulfobacterales 28221|Deltaproteobacteria K helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg k59_631812_1 404380.Gbem_3523 2.6e-26 113.0 COG2909@1|root,COG3629@1|root,COG2909@2|Bacteria,COG3629@2|Bacteria,1MVZZ@1224|Proteobacteria,43AN8@68525|delta/epsilon subdivisions,2X62F@28221|Deltaproteobacteria 28221|Deltaproteobacteria K Bacterial transcriptional activator domain - - - - - - - - - - - - BTAD k59_580795_1 325777.GW15_0200710 7.89e-13 68.2 COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,1RSEQ@1236|Gammaproteobacteria,1X3DR@135614|Xanthomonadales 135614|Xanthomonadales C Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates iorA - 1.2.7.8 ko:K04090 - - - - br01601,ko00000,ko01000 - - - POR,TPP_enzyme_C k59_580795_2 76114.ebA2917 2.19e-30 119.0 COG0477@1|root,COG2814@2|Bacteria,1MXPM@1224|Proteobacteria,2VHXT@28216|Betaproteobacteria,2KVE0@206389|Rhodocyclales 206389|Rhodocyclales EGP Sugar (and other) transporter - - - - - - - - - - - - MFS_1,Sugar_tr k59_1058440_1 1046625.AFQY01000003_gene2455 1.03e-12 61.6 2EJ6D@1|root,33CXK@2|Bacteria,1NHGW@1224|Proteobacteria,1SGZR@1236|Gammaproteobacteria,3NQBV@468|Moraxellaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1058440_2 795666.MW7_1882 3.11e-36 124.0 COG0776@1|root,COG0776@2|Bacteria,1MZ5B@1224|Proteobacteria,2VU4V@28216|Betaproteobacteria,1K8CW@119060|Burkholderiaceae 28216|Betaproteobacteria L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions hupB - - ko:K03530 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding k59_1058440_3 1163617.SCD_n01771 8.43e-40 147.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,2VIAU@28216|Betaproteobacteria 28216|Betaproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_374193_2 443144.GM21_0631 1.28e-08 57.4 COG1734@1|root,COG1734@2|Bacteria,1NH80@1224|Proteobacteria,42TPK@68525|delta/epsilon subdivisions,2X6N1@28221|Deltaproteobacteria,43UXV@69541|Desulfuromonadales 28221|Deltaproteobacteria K Prokaryotic dksA/traR C4-type zinc finger - - - ko:K06204 ko02026,map02026 - - - ko00000,ko00001,ko03000,ko03009,ko03021 - - - zf-dskA_traR k59_242643_1 187272.Mlg_2675 2.04e-39 154.0 COG2905@1|root,COG5001@1|root,COG2905@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1X0A7@135613|Chromatiales 135613|Chromatiales T Putative diguanylate phosphodiesterase - - - - - - - - - - - - CBS,EAL,GGDEF,PAS_9 k59_540600_1 561175.KB894099_gene5040 3.64e-46 165.0 COG0457@1|root,COG0457@2|Bacteria,2HG6N@201174|Actinobacteria,4EGR6@85012|Streptosporangiales 201174|Actinobacteria S Tetratricopeptide repeat - - - - - - - - - - - - - k59_112175_2 1121861.KB899945_gene3974 6.54e-06 47.4 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs MA20_27485 - 1.2.5.3 ko:K03520 - - R11168 RC02800 ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_413449_1 998674.ATTE01000001_gene2433 1.16e-50 174.0 COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,1RNQ8@1236|Gammaproteobacteria,460DY@72273|Thiotrichales 72273|Thiotrichales H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA - 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,GlutR_dimer,Shikimate_DH k59_1009228_1 1049564.TevJSym_bb00050 2.69e-13 70.5 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,1S0WV@1236|Gammaproteobacteria,1J5KF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases korA - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N k59_1009228_2 485913.Krac_6795 4.13e-50 169.0 COG1013@1|root,COG1013@2|Bacteria,2G679@200795|Chloroflexi 200795|Chloroflexi C PFAM thiamine pyrophosphate protein domain protein TPP-binding - - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFO_beta_C,TPP_enzyme_C k59_540646_1 754476.Q7A_2839 6.18e-38 146.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RR00@1236|Gammaproteobacteria,4601B@72273|Thiotrichales 72273|Thiotrichales EH Belongs to the TPP enzyme family - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1133564_1 1450694.BTS2_3075 9.26e-22 97.8 COG1623@1|root,COG1623@2|Bacteria,1TQD8@1239|Firmicutes,4HAQP@91061|Bacilli,1ZBIY@1386|Bacillus 91061|Bacilli L Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation disA - 2.7.7.85 ko:K07067 - - - - ko00000,ko01000 - - - DisA-linker,DisA_N,HHH,HHH_2 k59_949643_1 1485544.JQKP01000007_gene2024 1.85e-68 234.0 COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,2VJSZ@28216|Betaproteobacteria,44W8H@713636|Nitrosomonadales 28216|Betaproteobacteria T Histidine Phosphotransfer domain pilL - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_313178_1 1205680.CAKO01000006_gene3306 1.06e-95 288.0 COG1028@1|root,COG1028@2|Bacteria,1MWB6@1224|Proteobacteria,2TUKJ@28211|Alphaproteobacteria,2JVIA@204441|Rhodospirillales 204441|Rhodospirillales IQ KR domain - - 1.1.1.127 ko:K00065 ko00040,map00040 - R01542 RC00089 ko00000,ko00001,ko01000 - - - adh_short_C2 k59_1162843_1 909943.HIMB100_00002690 5.25e-112 338.0 COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,2TRTQ@28211|Alphaproteobacteria,4BPG5@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria EG Belongs to the IlvD Edd family ilvD GO:0003674,GO:0003824,GO:0004160,GO:0016829,GO:0016835,GO:0016836 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_823114_2 640081.Dsui_3533 8.72e-23 92.4 COG1714@1|root,COG1714@2|Bacteria,1REEC@1224|Proteobacteria,2VRE0@28216|Betaproteobacteria,2KWXJ@206389|Rhodocyclales 206389|Rhodocyclales S membrane protein domain - - - - - - - - - - - - RDD k59_99012_1 314256.OG2516_18440 3.01e-15 82.4 COG2931@1|root,COG3210@1|root,COG4070@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4070@2|Bacteria,1MU7T@1224|Proteobacteria,2V8V8@28211|Alphaproteobacteria,2PFGF@252301|Oceanicola 28211|Alphaproteobacteria Q COG2931, RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - - k59_1166325_1 381666.H16_B1300 4.21e-13 70.1 COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,2VHP1@28216|Betaproteobacteria,1K4GC@119060|Burkholderiaceae 28216|Betaproteobacteria C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) aceE1 GO:0000287,GO:0003674,GO:0003824,GO:0004738,GO:0005488,GO:0005515,GO:0008150,GO:0008152,GO:0016491,GO:0016903,GO:0019842,GO:0030976,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0046872,GO:0046983,GO:0048037,GO:0050662,GO:0055114,GO:0097159,GO:1901363,GO:1901681 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transketolase_C,Transketolase_N k59_1166325_2 1380394.JADL01000002_gene1796 4.49e-50 163.0 COG2050@1|root,COG2050@2|Bacteria,1PP3J@1224|Proteobacteria,2U5E4@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q protein possibly involved in aromatic compounds catabolism MA20_28520 - - - - - - - - - - - 4HBT k59_866005_1 1123508.JH636446_gene6313 5.2e-21 99.0 COG2931@1|root,COG3210@1|root,COG3291@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,COG3291@2|Bacteria,2J3HW@203682|Planctomycetes 203682|Planctomycetes QU calcium- and calmodulin-responsive adenylate cyclase activity - - - - - - - - - - - - - k59_866007_1 882378.RBRH_01237 5.35e-105 310.0 COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,2VH1U@28216|Betaproteobacteria,1K2NF@119060|Burkholderiaceae 28216|Betaproteobacteria C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit sucD GO:0003674,GO:0003824,GO:0004774,GO:0004776,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0016874,GO:0016877,GO:0016878,GO:0031974,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0070013 6.2.1.5 ko:K01902 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - CoA_binding,Ligase_CoA k59_228229_1 414684.RC1_3081 2.71e-16 75.5 COG4321@1|root,COG4321@2|Bacteria,1N6V0@1224|Proteobacteria,2UFNN@28211|Alphaproteobacteria,2JU24@204441|Rhodospirillales 204441|Rhodospirillales S Ribbon-helix-helix domain - - - - - - - - - - - - RHH_4 k59_228229_2 1449049.JONW01000002_gene2418 0.000148 41.6 COG0271@1|root,COG0271@2|Bacteria,1MZG5@1224|Proteobacteria,2UF6U@28211|Alphaproteobacteria,2KH96@204458|Caulobacterales 204458|Caulobacterales T Belongs to the BolA IbaG family - - - ko:K05527 - - - - ko00000,ko03000 - - - BolA k59_1209074_1 998674.ATTE01000001_gene4209 9.73e-82 253.0 COG1398@1|root,COG1398@2|Bacteria,1N2MA@1224|Proteobacteria,1RSN1@1236|Gammaproteobacteria,463KW@72273|Thiotrichales 72273|Thiotrichales I Transposase - - - - - - - - - - - - DDE_Tnp_ISL3,FA_desaturase k59_910681_1 1122613.ATUP01000001_gene1525 1.37e-06 50.1 COG1525@1|root,COG1525@2|Bacteria,1N0I9@1224|Proteobacteria,2UBYJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria L nuclease - - - - - - - - - - - - SNase k59_910681_2 1125973.JNLC01000017_gene3512 5.01e-24 98.2 COG0639@1|root,COG0639@2|Bacteria,1RD8M@1224|Proteobacteria,2U7N2@28211|Alphaproteobacteria,3JWKP@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Calcineurin-like phosphoesterase prp1 - 3.1.3.16 ko:K07313 - - - - ko00000,ko01000 - - - Metallophos k59_953200_1 76114.ebA3595 3.17e-59 193.0 COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,2VH51@28216|Betaproteobacteria,2KU9W@206389|Rhodocyclales 206389|Rhodocyclales O Peptidase U32 - - - ko:K08303 ko05120,map05120 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_U32 k59_1084763_1 1123253.AUBD01000002_gene1308 5.65e-17 90.9 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1X9AY@135614|Xanthomonadales 135614|Xanthomonadales T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS_3,PAS_4,PAS_9 k59_740191_1 335543.Sfum_0937 4.9e-61 196.0 COG0204@1|root,COG0204@2|Bacteria,1MY51@1224|Proteobacteria,42QIX@68525|delta/epsilon subdivisions,2WJHE@28221|Deltaproteobacteria 28221|Deltaproteobacteria I Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family - - 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_17496_1 1286093.C266_20215 2.03e-98 305.0 COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,2VIGG@28216|Betaproteobacteria,1K1UR@119060|Burkholderiaceae 28216|Betaproteobacteria D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA - - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc k59_484444_1 472759.Nhal_1371 3.66e-82 255.0 COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,1RQAM@1236|Gammaproteobacteria,1WY70@135613|Chromatiales 135613|Chromatiales S peptidase dimerisation domain - - - - - - - - - - - - M20_dimer,Peptidase_M20 k59_186042_1 270374.MELB17_17794 1.87e-90 270.0 COG2209@1|root,COG2209@2|Bacteria,1R33S@1224|Proteobacteria,1RMWV@1236|Gammaproteobacteria,464ST@72275|Alteromonadaceae 1236|Gammaproteobacteria C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol nqrE GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008137,GO:0008150,GO:0008152,GO:0015672,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030001,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0051179,GO:0051234,GO:0055114,GO:0098796,GO:1902494 1.6.5.8 ko:K00350 - - - - ko00000,ko01000 - - - Rnf-Nqr k59_186042_2 34506.g1763 7.14e-38 143.0 2D1GV@1|root,2SI2U@2759|Eukaryota,3AIRA@33154|Opisthokonta,3BYFA@33208|Metazoa,3DE5D@33213|Bilateria 33208|Metazoa S NQRA C-terminal domain - - - - - - - - - - - - NQRA,NQRA_SLBB k59_615972_2 1123504.JQKD01000062_gene33 5.11e-21 92.8 COG1893@1|root,COG1893@2|Bacteria,1MVZ1@1224|Proteobacteria,2VJFW@28216|Betaproteobacteria,4A9R6@80864|Comamonadaceae 28216|Betaproteobacteria H Ketopantoate reductase panE - 1.1.1.169 ko:K00077 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R02472 RC00726 ko00000,ko00001,ko00002,ko01000 - - - ApbA,ApbA_C k59_61498_1 398767.Glov_0439 4.27e-15 81.3 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,42WT2@68525|delta/epsilon subdivisions,2WR9X@28221|Deltaproteobacteria 28221|Deltaproteobacteria L transposase IS116 IS110 IS902 family protein - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_1251886_2 1415780.JPOG01000001_gene2946 2.57e-52 191.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1X3Q4@135614|Xanthomonadales 135614|Xanthomonadales T GGDEF domain - - - - - - - - - - - - EAL,GGDEF k59_269641_1 1205680.CAKO01000014_gene99 5.09e-09 57.0 COG1028@1|root,COG1028@2|Bacteria,1NCD3@1224|Proteobacteria,2TTFD@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short_C2 k59_269641_2 543728.Vapar_4715 1.86e-49 160.0 COG0662@1|root,COG0662@2|Bacteria,1RH1E@1224|Proteobacteria,2VSQU@28216|Betaproteobacteria,4AEEV@80864|Comamonadaceae 28216|Betaproteobacteria G Cupin 2, conserved barrel - - - - - - - - - - - - Cupin_2 k59_269641_3 1007105.PT7_0667 2.08e-24 100.0 COG1960@1|root,COG1960@2|Bacteria,1MVAH@1224|Proteobacteria,2VM1E@28216|Betaproteobacteria,3T8R9@506|Alcaligenaceae 28216|Betaproteobacteria C acyl-CoA dehydrogenase - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1042448_1 1469613.JT55_16965 1.09e-136 393.0 COG3435@1|root,COG3435@2|Bacteria,1MVJP@1224|Proteobacteria,2TUUS@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q Gentisate 1,2-dioxygenase - - 1.13.11.4 ko:K00450 ko00350,ko01100,ko01120,map00350,map01100,map01120 - R02656 RC00764 ko00000,ko00001,ko01000 - - - Cupin_2 k59_1251905_1 395494.Galf_1181 1.67e-75 238.0 COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,2VKJ8@28216|Betaproteobacteria,44WDG@713636|Nitrosomonadales 28216|Betaproteobacteria KLT PFAM Serine threonine-protein kinase-like domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PEGA,Pkinase k59_484500_1 1126627.BAWE01000004_gene2387 4.48e-58 189.0 COG0411@1|root,COG0411@2|Bacteria,1MUFT@1224|Proteobacteria,2U22X@28211|Alphaproteobacteria,3JVSH@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Branched-chain amino acid ATP-binding cassette transporter - - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_1121723_1 118173.KB235914_gene3631 4.97e-05 49.3 COG1075@1|root,COG1075@2|Bacteria,1G2TT@1117|Cyanobacteria,1H9AV@1150|Oscillatoriales 1117|Cyanobacteria S Serine aminopeptidase, S33 - - - - - - - - - - - - Hydrolase_4 k59_1121723_2 338969.Rfer_4176 1.3e-72 237.0 COG2271@1|root,COG2271@2|Bacteria,1R8Q1@1224|Proteobacteria,2VKPK@28216|Betaproteobacteria,4ABJB@80864|Comamonadaceae 28216|Betaproteobacteria G Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_269683_1 90814.KL370891_gene746 3.24e-64 222.0 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,1RNK8@1236|Gammaproteobacteria,460U8@72273|Thiotrichales 72273|Thiotrichales Q PFAM Hemolysin-type calcium-binding repeat (2 copies) - - - - - - - - - - - - HCBP_related,He_PIG,HemolysinCabind k59_1293772_1 265072.Mfla_1709 2.15e-136 391.0 COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,2VIVG@28216|Betaproteobacteria,2KKJ5@206350|Nitrosomonadales 206350|Nitrosomonadales E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline - - 2.1.3.3 ko:K00611 ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230 M00029,M00844 R01398 RC00096 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_616095_1 283942.IL1615 7.53e-21 86.3 COG2963@1|root,COG2963@2|Bacteria,1N28U@1224|Proteobacteria,1S9BK@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Transposase - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 k59_616095_2 1441629.PCH70_05980 3.5e-20 90.1 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,1RR4F@1236|Gammaproteobacteria,1Z7QZ@136849|Pseudomonas syringae group 1236|Gammaproteobacteria L Integrase core domain - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve k59_17636_1 87626.PTD2_18870 2.27e-94 303.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,2Q0X3@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria V COG0841 Cation multidrug efflux pump - - - ko:K03296,ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_186180_1 1120956.JHZK01000002_gene1034 2.59e-49 165.0 COG0218@1|root,COG0218@2|Bacteria,1MY3Z@1224|Proteobacteria,2U5E5@28211|Alphaproteobacteria,1JNW0@119043|Rhodobiaceae 28211|Alphaproteobacteria D Necessary for normal cell division and for the maintenance of normal septation engB - - ko:K03978 - - - - ko00000,ko03036 - - - MMR_HSR1 k59_1340147_2 504487.JCM19302_879 5.07e-64 218.0 COG0612@1|root,COG0612@2|Bacteria,4NEDZ@976|Bacteroidetes,1HYRS@117743|Flavobacteriia 976|Bacteroidetes M Peptidase M16 - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_1293861_1 671143.DAMO_1007 9.96e-82 252.0 COG2801@1|root,COG2801@2|Bacteria,2NR9G@2323|unclassified Bacteria 2|Bacteria L Integrase core domain - - - ko:K07497 - - - - ko00000 - - - rve,rve_3 k59_740392_1 595460.RRSWK_03194 6.1e-76 246.0 COG2239@1|root,COG2239@2|Bacteria,2IYCZ@203682|Planctomycetes 203682|Planctomycetes P Acts as a magnesium transporter - - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_866264_1 887062.HGR_13039 5.43e-27 107.0 COG3181@1|root,COG3181@2|Bacteria,1MXEX@1224|Proteobacteria,2VKSV@28216|Betaproteobacteria,4AC49@80864|Comamonadaceae 28216|Betaproteobacteria S Tripartite tricarboxylate transporter family receptor - - - - - - - - - - - - TctC k59_995992_1 243924.LT42_24330 2.36e-52 174.0 COG3622@1|root,COG3622@2|Bacteria,1MV53@1224|Proteobacteria,1RQF9@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Belongs to the hyi family ygbM - 5.3.1.35 ko:K22131 - - - - ko00000,ko01000 - - - AP_endonuc_2 k59_359807_1 517417.Cpar_1485 1.16e-05 47.8 COG1452@1|root,COG1452@2|Bacteria,1FEGW@1090|Chlorobi 1090|Chlorobi M Putative MetA-pathway of phenol degradation - - - - - - - - - - - - Phenol_MetA_deg k59_1293881_1 977880.RALTA_B1690 3.42e-126 367.0 COG0191@1|root,COG0191@2|Bacteria,1MURX@1224|Proteobacteria,2VHGI@28216|Betaproteobacteria,1K2B5@119060|Burkholderiaceae 28216|Betaproteobacteria G Class II cbbA - 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - F_bP_aldolase k59_953460_1 1244869.H261_00780 2.67e-104 330.0 COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,2U1PA@28211|Alphaproteobacteria,2JPJX@204441|Rhodospirillales 28211|Alphaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - - - - - - - - - - Molybdopterin,Molydop_binding k59_996009_1 469378.Ccur_06230 1.11e-22 98.6 COG0349@1|root,COG0349@2|Bacteria,2GKNM@201174|Actinobacteria,4CV2Q@84998|Coriobacteriia 84998|Coriobacteriia J Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides rnd - 3.1.13.5 ko:K03684 - - - - ko00000,ko01000,ko03016 - - - DNA_pol_A_exo1,HRDC k59_1293891_1 998674.ATTE01000001_gene2133 5.27e-108 332.0 COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,1RMTC@1236|Gammaproteobacteria,45ZVK@72273|Thiotrichales 72273|Thiotrichales L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parC - - ko:K02621 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseA_C,DNA_topoisoIV k59_953471_1 997296.PB1_15294 1.69e-65 218.0 COG0481@1|root,COG0481@2|Bacteria,1TP0G@1239|Firmicutes,4HASA@91061|Bacilli,1ZC7J@1386|Bacillus 91061|Bacilli M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner lepA - - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C k59_1293918_1 1411123.JQNH01000001_gene612 1.09e-45 156.0 COG2186@1|root,COG2186@2|Bacteria,1R5KH@1224|Proteobacteria,2TSJE@28211|Alphaproteobacteria 28211|Alphaproteobacteria K FCD - - - - - - - - - - - - FCD,GntR k59_1340306_1 1150599.MPHLEI_26837 3.65e-11 65.5 COG0558@1|root,COG0558@2|Bacteria,2GM3F@201174|Actinobacteria,236BF@1762|Mycobacteriaceae 201174|Actinobacteria I CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase pgsA2 GO:0003674,GO:0003824,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576 2.7.8.41,2.7.8.5 ko:K00995,ko:K08744 ko00564,ko01100,map00564,map01100 - R01801,R02030 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf k59_1209427_1 469610.HMPREF0189_00616 6.36e-76 256.0 COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,2VI3R@28216|Betaproteobacteria,1KJBK@119065|unclassified Burkholderiales 28216|Betaproteobacteria L TIGRFAM ATP-dependent helicase HrpA hrpA - 3.6.4.13 ko:K03578 - - - - ko00000,ko01000 - - - DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind k59_484738_1 1297742.A176_04402 7.85e-24 106.0 COG2133@1|root,COG2133@2|Bacteria,1PER7@1224|Proteobacteria,4399G@68525|delta/epsilon subdivisions,2X4GV@28221|Deltaproteobacteria,2YYZS@29|Myxococcales 28221|Deltaproteobacteria G Glucose / Sorbosone dehydrogenase - - - - - - - - - - - - GSDH k59_228583_1 1379698.RBG1_1C00001G1089 2.7e-05 51.6 COG3437@1|root,COG3437@2|Bacteria,2NP8B@2323|unclassified Bacteria 2|Bacteria T metal-dependent phosphohydrolase HD region - - - - - - - - - - - - GAF,GAF_2,GGDEF,HD,HD_5,PAS,PAS_3,PAS_9,Response_reg k59_141851_1 1035191.HMPREF0185_02402 7.12e-114 340.0 COG1228@1|root,COG1228@2|Bacteria,1MUYR@1224|Proteobacteria,2TSA1@28211|Alphaproteobacteria,2KFRA@204458|Caulobacterales 204458|Caulobacterales Q Imidazolone-5-propionate hydrolase hutI - 3.5.2.7 ko:K01468 ko00340,ko01100,map00340,map01100 M00045 R02288 RC00683 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1,Amidohydro_3 k59_186383_1 768671.ThimaDRAFT_3413 3.36e-71 234.0 COG0480@1|root,COG0480@2|Bacteria,1MVVY@1224|Proteobacteria,1RYCE@1236|Gammaproteobacteria,1WWXP@135613|Chromatiales 135613|Chromatiales J small GTP-binding protein - - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU k59_823556_1 323848.Nmul_A0022 2.32e-159 475.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,2VH6Z@28216|Betaproteobacteria,371VQ@32003|Nitrosomonadales 28216|Betaproteobacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_698017_1 397945.Aave_2022 4.98e-91 297.0 COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,1MVKX@1224|Proteobacteria,2VHW5@28216|Betaproteobacteria,4ABG1@80864|Comamonadaceae 28216|Betaproteobacteria G SMART alpha amylase catalytic sub domain treS - 3.2.1.1,5.4.99.16 ko:K05343 ko00500,ko01100,map00500,map01100 - R01557,R02108,R02112,R11262 RC01816 ko00000,ko00001,ko01000 - GH13 - APH,Alpha-amylase,Malt_amylase_C k59_141886_1 1207063.P24_08494 2.03e-68 220.0 COG0583@1|root,COG0583@2|Bacteria,1MVA1@1224|Proteobacteria,2TSUS@28211|Alphaproteobacteria,2JPGK@204441|Rhodospirillales 204441|Rhodospirillales K transcriptional regulator - - - ko:K04761 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - HTH_1,LysR_substrate k59_141886_2 715451.ambt_06195 4.08e-05 44.7 COG1814@1|root,COG1814@2|Bacteria,1MUZE@1224|Proteobacteria,1S2G7@1236|Gammaproteobacteria,466RY@72275|Alteromonadaceae 1236|Gammaproteobacteria S VIT family - - - - - - - - - - - - VIT1 k59_1042864_1 1380394.JADL01000003_gene5177 5.14e-41 146.0 COG3938@1|root,COG3938@2|Bacteria,1N02K@1224|Proteobacteria,2VGM8@28211|Alphaproteobacteria,2JSDZ@204441|Rhodospirillales 204441|Rhodospirillales E Proline racemase - - - - - - - - - - - - Pro_racemase k59_1042864_2 83344.XP_007924574.1 8.55e-08 52.8 COG0626@1|root,KOG0053@2759|Eukaryota,38F3Q@33154|Opisthokonta,3NVTU@4751|Fungi,3QPPV@4890|Ascomycota,1ZZP4@147541|Dothideomycetes,3MJET@451867|Dothideomycetidae 4751|Fungi E CoA binding domain MET15 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003961,GO:0004124,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006555,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009086,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016765,GO:0017144,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0050667,GO:0071265,GO:0071266,GO:0071268,GO:0071269,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.47,2.5.1.49 ko:K17069 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - CoA_binding_2,Cys_Met_Meta_PP k59_1085286_1 522306.CAP2UW1_2397 1.12e-26 110.0 28H91@1|root,2Z7KU@2|Bacteria,1R4NB@1224|Proteobacteria,2VS45@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_1085286_2 1123261.AXDW01000003_gene1948 2.47e-33 126.0 COG3239@1|root,COG3239@2|Bacteria,1MW29@1224|Proteobacteria,1RPHS@1236|Gammaproteobacteria,1X48K@135614|Xanthomonadales 135614|Xanthomonadales I Fatty acid desaturase - - - - - - - - - - - - FA_desaturase k59_1294024_1 1408423.JHYA01000005_gene1924 1.4e-25 103.0 COG0494@1|root,COG0494@2|Bacteria,1V6F5@1239|Firmicutes,4H4EZ@909932|Negativicutes 909932|Negativicutes L Hydrolase, NUDIX family nudF - 3.6.1.13 ko:K01515 ko00230,map00230 - R01054 RC00002 ko00000,ko00001,ko01000 - - - NUDIX k59_1085304_1 1502852.FG94_00666 2.15e-77 255.0 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,2VI2G@28216|Betaproteobacteria,472BY@75682|Oxalobacteraceae 28216|Betaproteobacteria O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD - 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,GlnD_UR_UTase,HD,NTP_transf_2 k59_788681_2 640081.Dsui_1968 7.26e-99 293.0 COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,2VIND@28216|Betaproteobacteria,2KU8F@206389|Rhodocyclales 206389|Rhodocyclales S Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates surE - 3.1.3.5 ko:K03787 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - SurE k59_1254170_2 748247.AZKH_0343 5.36e-61 195.0 COG3245@1|root,COG3245@2|Bacteria,1RJCX@1224|Proteobacteria,2VTRB@28216|Betaproteobacteria 28216|Betaproteobacteria C Cytochrome c7 and related cytochrome c - - - - - - - - - - - - Cytochrome_C7 k59_699963_1 443598.AUFA01000002_gene2620 3.67e-72 229.0 COG2055@1|root,COG2055@2|Bacteria,1MWQY@1224|Proteobacteria,2TR37@28211|Alphaproteobacteria,3JT0K@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Belongs to the LDH2 MDH2 oxidoreductase family MA20_16505 - 1.1.1.350 ko:K00073,ko:K13574 ko00230,ko01120,map00230,map01120 - R02935,R02936 RC00169 ko00000,ko00001,ko01000 - - - Ldh_2 k59_1087687_1 1046724.KB889872_gene2365 9.19e-13 72.4 COG3677@1|root,COG3677@2|Bacteria,1NUTK@1224|Proteobacteria,1S2MZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Transposase zinc-ribbon domain - - - - - - - - - - - - DDE_Tnp_IS1595,Zn_Tnp_IS1595 k59_825222_1 391615.ABSJ01000026_gene121 1.05e-85 266.0 2CIBN@1|root,2Z8JT@2|Bacteria,1R902@1224|Proteobacteria,1RXPM@1236|Gammaproteobacteria,1J8X1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Metal dependent phosphohydrolases with conserved 'HD' motif. - - - - - - - - - - - - - k59_486805_2 1381123.AYOD01000013_gene2196 1.05e-45 159.0 COG2358@1|root,COG2358@2|Bacteria,1R8QD@1224|Proteobacteria,2U7M9@28211|Alphaproteobacteria,43KXK@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S NMT1-like family - - - ko:K07080 - - - - ko00000 - - - NMT1_3 k59_1168819_1 1122137.AQXF01000002_gene445 2.55e-67 226.0 COG1629@1|root,COG4771@2|Bacteria,1MVFB@1224|Proteobacteria,2U1V9@28211|Alphaproteobacteria 28211|Alphaproteobacteria P TonB-dependent Receptor Plug Domain - - - - - - - - - - - - Plug,TonB_dep_Rec k59_64453_1 1123372.AUIT01000014_gene1596 4.17e-19 90.9 COG1290@1|root,COG1290@2|Bacteria,2GHDS@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis - - - - - - - - - - - - - k59_188406_1 1121940.AUDZ01000012_gene951 2.37e-53 184.0 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,1RPM2@1236|Gammaproteobacteria,1XHE1@135619|Oceanospirillales 135619|Oceanospirillales L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins - - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C,Intein_splicing,LAGLIDADG_3 k59_618901_2 62928.azo1537 1.19e-39 139.0 COG3576@1|root,COG3576@2|Bacteria,1N8Z5@1224|Proteobacteria,2VVVW@28216|Betaproteobacteria,2KX6P@206389|Rhodocyclales 206389|Rhodocyclales S pyridoxamine 5-phosphate - - - - - - - - - - - - - k59_401397_1 1437824.BN940_02876 1.43e-12 73.6 28IAN@1|root,2Z8D8@2|Bacteria,1NJD6@1224|Proteobacteria,2VVGV@28216|Betaproteobacteria,3T86Q@506|Alcaligenaceae 28216|Betaproteobacteria S to Bacteriophage MB78 60 kDa protein gp62 SWALL Q9T0Q3 (EMBL Y19202) (540 aa) fasta scores E() 2.1e-31, 31.2 id in 455 aa - - - - - - - - - - - - DUF4055 k59_913180_1 436308.Nmar_1273 2.76e-67 212.0 COG3794@1|root,arCOG02926@2157|Archaea 2157|Archaea C PFAM blue (type 1) copper domain protein - - - - - - - - - - - - Copper-bind k59_19962_1 1229205.BUPH_08508 6.35e-114 337.0 COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,2VNSH@28216|Betaproteobacteria,1KGQD@119060|Burkholderiaceae 28216|Betaproteobacteria L Phage integrase, N-terminal SAM-like domain - - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_4,Phage_integrase k59_320604_1 1163617.SCD_n00668 5.53e-121 351.0 COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,2VIA5@28216|Betaproteobacteria 28216|Betaproteobacteria K transcriptional regulatory protein yebC - - - - - - - - - - - Transcrip_reg k59_320604_2 1380394.JADL01000001_gene2257 6.56e-48 165.0 COG0697@1|root,COG0697@2|Bacteria,1MYHQ@1224|Proteobacteria,2U4JI@28211|Alphaproteobacteria,2JUE6@204441|Rhodospirillales 204441|Rhodospirillales EG EamA-like transporter family - - - - - - - - - - - - EamA k59_998211_1 29581.BW37_01860 1.31e-32 124.0 COG2197@1|root,COG2197@2|Bacteria,1RGN8@1224|Proteobacteria,2VRZK@28216|Betaproteobacteria,47766@75682|Oxalobacteraceae 28216|Betaproteobacteria K helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg k59_320636_1 941449.dsx2_1498 4.86e-20 91.3 COG2202@1|root,COG4585@1|root,COG2202@2|Bacteria,COG4585@2|Bacteria,1PGDJ@1224|Proteobacteria,435NJ@68525|delta/epsilon subdivisions,2X01U@28221|Deltaproteobacteria,2M9UQ@213115|Desulfovibrionales 28221|Deltaproteobacteria T Integral membrane sensor signal transduction histidine kinase - - - - - - - - - - - - HATPase_c,HisKA_3 k59_656892_2 420662.Mpe_A1212 9.16e-62 194.0 COG2332@1|root,COG2332@2|Bacteria,1RHN5@1224|Proteobacteria,2VRKZ@28216|Betaproteobacteria,1KKY8@119065|unclassified Burkholderiales 28216|Betaproteobacteria O Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH ccmE - - ko:K02197 - - - - ko00000 - - - CcmE k59_656892_3 935567.JAES01000004_gene114 1.9e-28 114.0 COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,1RMY5@1236|Gammaproteobacteria,1X4P1@135614|Xanthomonadales 135614|Xanthomonadales O Cytochrome C biogenesis ccmF2 - - ko:K02198 - - - - ko00000,ko02000 9.B.14.1 - - CcmF_C,Cytochrom_C_asm k59_825348_1 497321.C664_10782 6.73e-98 301.0 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2VH5A@28216|Betaproteobacteria,2KV7J@206389|Rhodocyclales 206389|Rhodocyclales C glycolate oxidase subunit GlcD - - - - - - - - - - - - FAD-oxidase_C,FAD_binding_4 k59_1254352_1 948106.AWZT01000020_gene4110 2.44e-16 72.8 COG0695@1|root,COG0695@2|Bacteria,1N72P@1224|Proteobacteria,2VU2J@28216|Betaproteobacteria,1K8MR@119060|Burkholderiaceae 28216|Betaproteobacteria O Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins grxC - - ko:K03676 - - - - ko00000,ko03110 - - - Glutaredoxin k59_1254352_2 279714.FuraDRAFT_2828 2.47e-54 175.0 COG1952@1|root,COG1952@2|Bacteria,1RI75@1224|Proteobacteria,2VQ1Q@28216|Betaproteobacteria,2KR9B@206351|Neisseriales 206351|Neisseriales U One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA secB - - ko:K03071 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03110 3.A.5 - - SecB k59_955724_1 93220.LV28_10940 1.89e-73 232.0 COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,2VJN0@28216|Betaproteobacteria,1K14B@119060|Burkholderiaceae 28216|Betaproteobacteria H Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) pdxA - 1.1.1.262 ko:K00097 ko00750,ko01100,map00750,map01100 M00124 R05681,R05837,R07406 RC00089,RC00675,RC01475 ko00000,ko00001,ko00002,ko01000 - - - PdxA k59_619045_1 1089546.AQUI01000002_gene3075 2.48e-05 52.4 COG2301@1|root,COG2301@2|Bacteria,2GK5J@201174|Actinobacteria 201174|Actinobacteria G Belongs to the HpcH HpaI aldolase family - - 4.1.3.34 ko:K01644 ko02020,map02020 - R00362 RC00067,RC01118 ko00000,ko00001,ko01000 - - - HpcH_HpaI k59_955762_1 331869.BAL199_21684 1.06e-58 191.0 COG1234@1|root,COG1234@2|Bacteria,1R64Z@1224|Proteobacteria,2TU6T@28211|Alphaproteobacteria 28211|Alphaproteobacteria S COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III - - - - - - - - - - - - Lactamase_B,Lactamase_B_2 k59_1254385_1 944481.JAFP01000001_gene1086 9.15e-27 112.0 COG1574@1|root,COG1574@2|Bacteria,1Q97Z@1224|Proteobacteria,42MRZ@68525|delta/epsilon subdivisions,2WMK2@28221|Deltaproteobacteria,2M6R6@213113|Desulfurellales 28221|Deltaproteobacteria S Pfam:DUF1446 - - - - - - - - - - - - AtuA k59_1045523_1 1121272.KB903249_gene1515 4.05e-77 255.0 COG1404@1|root,COG4935@1|root,COG1404@2|Bacteria,COG4935@2|Bacteria,2I9U6@201174|Actinobacteria,4DH83@85008|Micromonosporales 201174|Actinobacteria O Proprotein convertase P-domain - - - - - - - - - - - - P_proprotein,Peptidase_S8 k59_742766_1 338969.Rfer_2156 8.96e-68 233.0 COG1640@1|root,COG3280@1|root,COG1640@2|Bacteria,COG3280@2|Bacteria,1QTVJ@1224|Proteobacteria,2WGPV@28216|Betaproteobacteria,4AD3R@80864|Comamonadaceae 28216|Betaproteobacteria G SMART alpha amylase catalytic sub domain treY - 2.4.1.25,5.4.99.15 ko:K00705,ko:K06044 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R01824,R05196,R09995 RC00049 ko00000,ko00001,ko00002,ko01000 - GH13,GH77 - Alpha-amylase,Glyco_hydro_77 k59_1169046_1 1123389.ATXJ01000003_gene328 6.07e-78 251.0 COG0365@1|root,COG0365@2|Bacteria,1WI8W@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus I Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_789026_1 441620.Mpop_3824 1.36e-83 262.0 COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2TRXG@28211|Alphaproteobacteria,1JZ9R@119045|Methylobacteriaceae 28211|Alphaproteobacteria L Transposase domain (DUF772) - - - ko:K07487 - - - - ko00000 - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_1045581_2 83406.HDN1F_24450 5.89e-31 113.0 COG2363@1|root,COG2363@2|Bacteria,1MZX3@1224|Proteobacteria,1SCNB@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Small membrane protein ygdD GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - DUF423 k59_1045581_3 262724.TT_C1030 6e-05 41.6 2CAKS@1|root,30Q0J@2|Bacteria,1WKSR@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus J 30S ribosomal protein Thx - - - ko:K19033 - - - - br01610,ko00000,ko03011 - - - Thx k59_1045581_4 1045855.DSC_08390 7.9e-29 115.0 COG1410@1|root,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,1X36Z@135614|Xanthomonadales 135614|Xanthomonadales E 5-methyltetrahydrofolate--homocysteine methyltransferase metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_742802_1 1300345.LF41_2080 2.04e-58 193.0 COG2377@1|root,COG2377@2|Bacteria,1MV4E@1224|Proteobacteria,1RNTZ@1236|Gammaproteobacteria,1X4BE@135614|Xanthomonadales 135614|Xanthomonadales O Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling anmK - 2.7.1.170 ko:K09001 - - - - ko00000,ko01000 - - - AnmK k59_188622_1 1078020.KEK_01735 3.73e-35 134.0 COG1048@1|root,COG1048@2|Bacteria,2GJD5@201174|Actinobacteria,234YF@1762|Mycobacteriaceae 201174|Actinobacteria C aconitate hydratase acnA GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0005506,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008198,GO:0009060,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0015980,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0030312,GO:0030350,GO:0032787,GO:0040007,GO:0042221,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046459,GO:0046872,GO:0046914,GO:0047456,GO:0048037,GO:0050896,GO:0051536,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:1901363 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_188622_2 1120972.AUMH01000009_gene423 3.23e-30 112.0 COG2041@1|root,COG2041@2|Bacteria,1V1P9@1239|Firmicutes,4HFQC@91061|Bacilli,278B0@186823|Alicyclobacillaceae 91061|Bacilli S Oxidoreductase molybdopterin binding domain yuiH - - - - - - - - - - - Oxidored_molyb k59_271945_1 159087.Daro_0087 5.38e-49 161.0 COG1028@1|root,COG1028@2|Bacteria,1QKCK@1224|Proteobacteria,2VN0G@28216|Betaproteobacteria,2KXZG@206389|Rhodocyclales 206389|Rhodocyclales IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short_C2 k59_1343295_1 998674.ATTE01000001_gene508 5.65e-21 91.7 COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,1RMN6@1236|Gammaproteobacteria,45ZP9@72273|Thiotrichales 72273|Thiotrichales P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA trkH - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_1343295_2 1177179.A11A3_01200 7.86e-27 102.0 COG3791@1|root,COG3791@2|Bacteria,1N031@1224|Proteobacteria,1T0A4@1236|Gammaproteobacteria,1XKV1@135619|Oceanospirillales 135619|Oceanospirillales S Glutathione-dependent formaldehyde-activating enzyme - - - - - - - - - - - - GFA k59_1088070_1 1205680.CAKO01000038_gene1627 3.11e-48 161.0 2BZ0R@1|root,2Z7U0@2|Bacteria,1MX37@1224|Proteobacteria,2TSBD@28211|Alphaproteobacteria,2JR5M@204441|Rhodospirillales 204441|Rhodospirillales S Nitrile hydratase, alpha chain - - - - - - - - - - - - NHase_alpha k59_742850_1 1205680.CAKO01000002_gene2209 1.94e-48 164.0 COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,2TRXI@28211|Alphaproteobacteria,2JPZB@204441|Rhodospirillales 204441|Rhodospirillales EH Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate ilvC - 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 - - - IlvC,IlvN k59_742850_2 1123240.ATVO01000004_gene904 1.2e-18 81.3 COG0440@1|root,COG0440@2|Bacteria,1RAGN@1224|Proteobacteria,2U5CW@28211|Alphaproteobacteria,2K12R@204457|Sphingomonadales 204457|Sphingomonadales E acetolactate synthase ilvH - 2.2.1.6 ko:K01653 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - ACT,ACT_5,ALS_ss_C k59_998428_1 234267.Acid_0055 5.53e-50 166.0 2AY4N@1|root,31Q6J@2|Bacteria,3Y7H6@57723|Acidobacteria 57723|Acidobacteria - - - - - - - - - - - - - - - k59_700304_1 323848.Nmul_A0647 8.47e-119 363.0 COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,2VIDE@28216|Betaproteobacteria,372CB@32003|Nitrosomonadales 28216|Betaproteobacteria L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA - 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 k59_868425_1 489825.LYNGBM3L_39170 9.64e-113 343.0 COG0480@1|root,COG0480@2|Bacteria,1G2JV@1117|Cyanobacteria,1H85T@1150|Oscillatoriales 1117|Cyanobacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome - - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_20222_1 644966.Tmar_0710 4.53e-12 72.8 COG1178@1|root,COG1178@2|Bacteria 2|Bacteria P thiamine transport phnV - - ko:K02011 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - BPD_transp_1 k59_444491_1 760117.JN27_22120 1.33e-07 52.4 COG3245@1|root,COG3245@2|Bacteria,1MZBZ@1224|Proteobacteria,2VMBB@28216|Betaproteobacteria,476ER@75682|Oxalobacteraceae 28216|Betaproteobacteria C Cytochrome C oxidase, cbb3-type, subunit III - - - - - - - - - - - - Cytochrome_CBB3 k59_444491_2 522306.CAP2UW1_0674 5.49e-62 201.0 COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,2VIZ3@28216|Betaproteobacteria,1KPRN@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria H Belongs to the prokaryotic GSH synthase family gshB - 6.3.2.3 ko:K01920 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00497,R10994 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - GSH-S_ATP,GSH-S_N k59_230847_1 1440053.JOEI01000009_gene5939 1.22e-43 164.0 COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria 201174|Actinobacteria T signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - - - - - - - - - - EAL,GGDEF k59_998459_1 485916.Dtox_1820 2.99e-21 92.0 COG3344@1|root,COG3344@2|Bacteria,1TP9A@1239|Firmicutes,248M4@186801|Clostridia,2644N@186807|Peptococcaceae 186801|Clostridia L Group II intron, maturase-specific domain - - - - - - - - - - - - GIIM,RVT_1 k59_1254575_2 644107.SL1157_0789 9.48e-14 69.7 2C9TS@1|root,347R4@2|Bacteria,1P2X7@1224|Proteobacteria,2UUNG@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_444534_1 1245471.PCA10_08060 7.04e-47 164.0 COG1466@1|root,COG1466@2|Bacteria,1MWYT@1224|Proteobacteria,1RQRE@1236|Gammaproteobacteria,1YE5K@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria L Processivity clamp loader gamma complex DNA pol III C-term holA GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02340 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delt_C,DNA_pol3_delta k59_619359_2 358220.C380_11145 5.22e-41 149.0 COG5473@1|root,COG5473@2|Bacteria,1MVRU@1224|Proteobacteria,2VK3K@28216|Betaproteobacteria,4ACB6@80864|Comamonadaceae 28216|Betaproteobacteria S Predicted integral membrane protein (DUF2189) - - - - - - - - - - - - DUF2189 k59_868510_1 335659.S23_50100 1.04e-34 134.0 COG5476@1|root,COG5476@2|Bacteria,1MX4P@1224|Proteobacteria,2TS1C@28211|Alphaproteobacteria,3JVJY@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Involved in peptidolytic degradation of cyclic heptapeptide hepatotoxin microcystin (MC) - - - - - - - - - - - - DUF1485,MlrC_C k59_64977_1 1207063.P24_17347 4.15e-72 226.0 COG2755@1|root,COG2755@2|Bacteria,1QM85@1224|Proteobacteria,2U34V@28211|Alphaproteobacteria 28211|Alphaproteobacteria E lipolytic protein G-D-S-L family - - - - - - - - - - - - - k59_64977_2 1242864.D187_004195 1.24e-14 73.2 COG0846@1|root,COG0846@2|Bacteria,1MUK1@1224|Proteobacteria,42SWD@68525|delta/epsilon subdivisions,2WK1W@28221|Deltaproteobacteria,2YYDA@29|Myxococcales 28221|Deltaproteobacteria K Sir2 family cobB - - ko:K12410 - - - - ko00000,ko01000 - - - SIR2 k59_1088265_1 251221.35211704 2.1e-14 72.8 COG0848@1|root,COG0848@2|Bacteria 2|Bacteria U biopolymer transport protein - - - ko:K03559,ko:K03560 - - - - ko00000,ko02000 1.A.30.2.1,1.A.30.2.2 - - ExbD k59_956049_1 91464.S7335_2489 2.01e-06 55.8 COG0642@1|root,COG0745@1|root,COG2204@1|root,COG0745@2|Bacteria,COG2204@2|Bacteria,COG2205@2|Bacteria,1G09B@1117|Cyanobacteria 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,PAS_9,Response_reg k59_789310_1 1357272.AVEO02000144_gene1782 5.11e-33 127.0 COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,1RNC8@1236|Gammaproteobacteria,1Z9GJ@136849|Pseudomonas syringae group 1236|Gammaproteobacteria S Oligopeptide transporter, OPT family oliA GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0008150,GO:0016020,GO:0022857,GO:0051179,GO:0051234,GO:0055085 - - - - - - - - - - OPT k59_367958_2 864702.OsccyDRAFT_4774 1.56e-09 63.9 COG2159@1|root,COG2159@2|Bacteria,1G3DV@1117|Cyanobacteria,1HAHP@1150|Oscillatoriales 1117|Cyanobacteria S metal-dependent hydrolase of the TIM-barrel fold - - - - - - - - - - - - Amidohydro_2 k59_704906_1 279714.FuraDRAFT_1061 1.99e-07 51.2 COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,2VI2C@28216|Betaproteobacteria,2KPQP@206351|Neisseriales 206351|Neisseriales P Plays a role in the regulation of phosphate uptake phoU - - ko:K02039 - - - - ko00000 - - - PhoU k59_704906_2 76114.ebA1080 2.77e-66 207.0 COG0120@1|root,COG0120@2|Bacteria,1MVGR@1224|Proteobacteria,2VH27@28216|Betaproteobacteria,2KUHS@206389|Rhodocyclales 206389|Rhodocyclales G Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate rpiA - 5.3.1.6 ko:K01807 ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167,M00580 R01056 RC00434 ko00000,ko00001,ko00002,ko01000 - - - Rib_5-P_isom_A k59_661964_1 519989.ECTPHS_05851 1.36e-86 265.0 COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,1RQ49@1236|Gammaproteobacteria,1WW6K@135613|Chromatiales 135613|Chromatiales H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate ribB - 3.5.4.25,4.1.99.12 ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 - - - DHBP_synthase,GTP_cyclohydro2 k59_1216492_1 1538295.JY96_05805 8.02e-213 601.0 COG0318@1|root,COG0318@2|Bacteria,1MUMC@1224|Proteobacteria,2VIJ8@28216|Betaproteobacteria,1KJ4H@119065|unclassified Burkholderiales 28216|Betaproteobacteria IQ PFAM AMP-dependent synthetase and ligase - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_1259164_1 1100720.ALKN01000033_gene659 1.02e-20 89.0 COG2863@1|root,COG2863@2|Bacteria,1PFFQ@1224|Proteobacteria,2VXBF@28216|Betaproteobacteria,4AFPX@80864|Comamonadaceae 28216|Betaproteobacteria C cytochrome - - - - - - - - - - - - Cytochrome_CBB3 k59_1259164_2 1100720.ALKN01000033_gene658 1.09e-29 115.0 COG2133@1|root,COG2133@2|Bacteria,1MVK5@1224|Proteobacteria,2VIRC@28216|Betaproteobacteria,4ACEX@80864|Comamonadaceae 28216|Betaproteobacteria G Glucose / Sorbosone dehydrogenase - - - - - - - - - - - - GSDH,SGL k59_491717_1 1283300.ATXB01000001_gene89 1.08e-34 136.0 COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,1RMPC@1236|Gammaproteobacteria,1XEPA@135618|Methylococcales 135618|Methylococcales O Belongs to the peptidase S16 family - - - - - - - - - - - - AAA_32,Lon_C k59_406374_1 243233.MCA0468 1.78e-62 202.0 COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,1RP45@1236|Gammaproteobacteria,1XE09@135618|Methylococcales 135618|Methylococcales S associated with various cellular activities - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_794223_1 1449065.JMLL01000010_gene173 7.04e-07 50.1 COG1023@1|root,COG1023@2|Bacteria,1QU14@1224|Proteobacteria,2TT6S@28211|Alphaproteobacteria,43IEI@69277|Phyllobacteriaceae 28211|Alphaproteobacteria G 6-phosphogluconate dehydrogenase gnd - 1.1.1.343,1.1.1.44 ko:K00033 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200 M00004,M00006 R01528,R10221 RC00001,RC00539 ko00000,ko00001,ko00002,ko01000 - - - 6PGD,NAD_binding_2 k59_481542_2 1384056.N787_13605 2.64e-35 129.0 COG3832@1|root,COG3832@2|Bacteria,1N2PR@1224|Proteobacteria,1S71Z@1236|Gammaproteobacteria,1X6KN@135614|Xanthomonadales 135614|Xanthomonadales J glyoxalase III activity - - - - - - - - - - - - Polyketide_cyc2 k59_481542_3 1095769.CAHF01000006_gene1753 1.25e-32 122.0 COG0846@1|root,COG0846@2|Bacteria,1MUK1@1224|Proteobacteria,2VJUU@28216|Betaproteobacteria,475MD@75682|Oxalobacteraceae 28216|Betaproteobacteria K Sir2 family cobB - - - - - - - - - - - SIR2 k59_1038907_2 1333856.L686_16900 1.9e-13 68.9 COG0846@1|root,COG0846@2|Bacteria,1MUK1@1224|Proteobacteria,1RMX5@1236|Gammaproteobacteria,1Z2I0@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria K COG0846 NAD-dependent protein deacetylases, SIR2 family cobB2 - - ko:K12410 - - - - ko00000,ko01000 - - - SIR2 k59_737330_1 257310.BB1585 4.87e-86 266.0 COG0697@1|root,COG0697@2|Bacteria,1MV7Y@1224|Proteobacteria,2VR8Q@28216|Betaproteobacteria 28216|Betaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA k59_907848_1 76114.ebA1293 3.33e-109 319.0 COG0106@1|root,COG0106@2|Bacteria,1MW6S@1224|Proteobacteria,2VI38@28216|Betaproteobacteria,2KUM6@206389|Rhodocyclales 206389|Rhodocyclales E 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase hisA - 5.3.1.16 ko:K01814 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04640 RC00945 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth k59_694816_1 339670.Bamb_0680 9.03e-81 246.0 COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,2VJPW@28216|Betaproteobacteria,1K1BT@119060|Burkholderiaceae 28216|Betaproteobacteria U PFAM MotA TolQ ExbB proton channel tolQ - - ko:K03562 ko01120,map01120 - - - ko00000,ko02000 1.A.30.2.2 - - MotA_ExbB k59_1249001_1 215803.DB30_1899 1.72e-35 139.0 COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,43BQE@68525|delta/epsilon subdivisions,2X71H@28221|Deltaproteobacteria,2YX6T@29|Myxococcales 28221|Deltaproteobacteria I Biotin carboxylase C-terminal domain - - 6.4.1.4,6.4.1.5 ko:K01968,ko:K13777 ko00280,ko00281,ko01100,map00280,map00281,map01100 M00036 R03494,R04138 RC00367,RC00942 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_1336407_1 391735.Veis_1010 1.91e-38 147.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2VHAN@28216|Betaproteobacteria,4A9XP@80864|Comamonadaceae 28216|Betaproteobacteria V Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation msbA - - ko:K02021,ko:K11085 ko02010,map02010 - - - ko00000,ko00001,ko01000,ko02000 3.A.1.106,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21 - - ABC_membrane,ABC_tran k59_782346_1 388051.AUFE01000005_gene1094 1.77e-120 350.0 COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,2VHZW@28216|Betaproteobacteria,1K11F@119060|Burkholderiaceae 28216|Betaproteobacteria O PFAM band 7 protein - - - - - - - - - - - - Band_7 k59_782346_2 292415.Tbd_0491 3.23e-13 69.7 COG1030@1|root,COG1030@2|Bacteria,1MUJN@1224|Proteobacteria,2VMUK@28216|Betaproteobacteria 28216|Betaproteobacteria O serine protease nfeD - - ko:K07403 - - - - ko00000 - - - NfeD k59_183245_1 1121035.AUCH01000027_gene3400 9.26e-40 145.0 COG0438@1|root,COG0438@2|Bacteria,1MVB4@1224|Proteobacteria,2VNQ8@28216|Betaproteobacteria,2KWKZ@206389|Rhodocyclales 206389|Rhodocyclales M Glycosyltransferase Family 4 - - 2.4.1.348 ko:K12995 - - - - ko00000,ko01000,ko01003,ko01005 - GT4 - Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1,Glycos_transf_2 k59_439016_1 1056820.KB900699_gene1338 2.83e-06 54.3 COG1629@1|root,COG4771@2|Bacteria,1R5B9@1224|Proteobacteria,1SZT1@1236|Gammaproteobacteria,2PPV4@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1119308_1 795666.MW7_2007 1.89e-17 82.0 COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VKMJ@28216|Betaproteobacteria,1K0WK@119060|Burkholderiaceae 28216|Betaproteobacteria S Tripartite tricarboxylate transporter family receptor - - - - - - - - - - - - TctC k59_1119308_2 204773.HEAR3330 1.84e-50 168.0 COG1951@1|root,COG1951@2|Bacteria,1MUV9@1224|Proteobacteria,2VIP7@28216|Betaproteobacteria,472YG@75682|Oxalobacteraceae 1224|Proteobacteria C Catalyzes the reversible hydration of fumarate to (S)- malate ttdA - 4.2.1.2,4.2.1.32 ko:K01677,ko:K03779 ko00020,ko00620,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00630,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00339,R01082 RC00443,RC01382 ko00000,ko00001,ko00002,ko01000 - - - Fumerase k59_612603_1 614083.AWQR01000009_gene731 5.2e-97 305.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,4ACRA@80864|Comamonadaceae 28216|Betaproteobacteria NU General secretory system II, protein E domain protein - - - ko:K02454,ko:K02652,ko:K12276 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - GAF,T2SSE,T2SSE_N k59_950496_1 1313172.YM304_20340 7.89e-62 201.0 COG0082@1|root,COG0082@2|Bacteria,2GJJN@201174|Actinobacteria,4CMPX@84992|Acidimicrobiia 84992|Acidimicrobiia E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system aroC - 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 - - - Chorismate_synt k59_782406_1 1121033.AUCF01000032_gene2622 2.5e-58 192.0 COG0665@1|root,COG0665@2|Bacteria,1MY0G@1224|Proteobacteria,2TRM2@28211|Alphaproteobacteria,2JPDU@204441|Rhodospirillales 204441|Rhodospirillales E FAD dependent oxidoreductase - - 1.4.99.6 ko:K19746 ko00472,ko01100,map00472,map01100 - R11018 RC00006 ko00000,ko00001,ko01000 - - - DAO k59_907962_2 522306.CAP2UW1_3009 7.48e-80 243.0 COG0741@1|root,COG0741@2|Bacteria,1R666@1224|Proteobacteria,2VHI4@28216|Betaproteobacteria 28216|Betaproteobacteria M PFAM Lytic transglycosylase catalytic - - - - - - - - - - - - SLT k59_314293_1 1217718.ALOU01000007_gene1361 1.25e-08 54.7 COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,2VIUA@28216|Betaproteobacteria,1JZWS@119060|Burkholderiaceae 28216|Betaproteobacteria J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another frr - - ko:K02838 - - - - ko00000,ko03012 - - - RRF k59_314293_2 402626.Rpic_1282 2.58e-121 353.0 COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,2VH2E@28216|Betaproteobacteria,1K0E6@119060|Burkholderiaceae 28216|Betaproteobacteria H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids uppS - 2.5.1.31 ko:K00806 ko00900,ko01110,map00900,map01110 - R06447 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 - - - Prenyltransf k59_1119346_1 987059.RBXJA2T_01535 5.16e-33 130.0 COG0491@1|root,COG0491@2|Bacteria,1MVC3@1224|Proteobacteria,2VICE@28216|Betaproteobacteria,1KN7G@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B,NUDIX k59_14728_1 399795.CtesDRAFT_PD0440 2.9e-69 226.0 COG0154@1|root,COG0154@2|Bacteria,1MU51@1224|Proteobacteria,2VJN4@28216|Betaproteobacteria,4ACWQ@80864|Comamonadaceae 28216|Betaproteobacteria J Amidase - - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_907998_1 402626.Rpic_2426 5.06e-91 285.0 COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,2VHXG@28216|Betaproteobacteria,1K2IB@119060|Burkholderiaceae 28216|Betaproteobacteria H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,Transket_pyr,Transketolase_C k59_524398_1 936053.I1BXE6 6.38e-08 59.3 COG0639@1|root,KOG0374@2759|Eukaryota,39ZGT@33154|Opisthokonta,3P1A9@4751|Fungi,1GTY6@112252|Fungi incertae sedis 4751|Fungi T phosphatase - GO:0000298,GO:0000322,GO:0000323,GO:0000324,GO:0000328,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005773,GO:0005775,GO:0006082,GO:0006091,GO:0006112,GO:0006793,GO:0006797,GO:0006798,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0015980,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0031974,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044422,GO:0044424,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0055114,GO:0070013,GO:0071704,GO:1901575 - - - - - - - - - - Metallophos k59_139208_1 331869.BAL199_11786 1.11e-85 269.0 COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,2TVYU@28211|Alphaproteobacteria,4BRTN@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria EQ N-methylhydantoinase B acetone carboxylase, alpha subunit hyuB - 3.5.2.14 ko:K01474 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydantoinase_B k59_267227_1 1408473.JHXO01000008_gene2832 0.000962 45.4 COG0815@1|root,COG0815@2|Bacteria,4NMJK@976|Bacteroidetes 976|Bacteroidetes M Carbon-nitrogen hydrolase - - - ko:K03820 - - - - ko00000,ko01000 - GT2 - CN_hydrolase k59_267227_2 1123269.NX02_02995 8.99e-20 87.8 2DMP1@1|root,32SS8@2|Bacteria,1N0XZ@1224|Proteobacteria,2UBZ9@28211|Alphaproteobacteria,2K5H8@204457|Sphingomonadales 204457|Sphingomonadales S Belongs to the UPF0311 family - - - - - - - - - - - - DUF3237 k59_993154_1 159087.Daro_0259 1.53e-14 77.0 COG1716@1|root,COG2114@1|root,COG1716@2|Bacteria,COG2114@2|Bacteria 2|Bacteria T Pfam Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - FHA,Guanylate_cyc k59_993154_2 339670.Bamb_0683 9.52e-69 220.0 COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,2VJ4F@28216|Betaproteobacteria,1K0G0@119060|Burkholderiaceae 28216|Betaproteobacteria E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT k59_58177_1 981384.AEYW01000004_gene1769 1.89e-57 193.0 COG3659@1|root,COG3659@2|Bacteria,1R8TI@1224|Proteobacteria 1224|Proteobacteria M Carbohydrate-selective porin OprB - - - ko:K07267 - - - - ko00000,ko02000 1.B.19.1 - - OprB k59_737576_1 94624.Bpet0778 3.21e-74 245.0 COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,2VICG@28216|Betaproteobacteria,3T227@506|Alcaligenaceae 28216|Betaproteobacteria J Glycyl-tRNA synthetase beta subunit glyS - 6.1.1.14 ko:K01879 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_1,tRNA_synt_2f k59_950629_2 622637.KE124773_gene4163 6.62e-10 62.4 COG1765@1|root,COG1765@2|Bacteria 2|Bacteria O OsmC-like protein - - - - - - - - - - - - OsmC k59_1291231_1 1207063.P24_09756 5.77e-73 232.0 COG0624@1|root,COG0624@2|Bacteria,1MW6G@1224|Proteobacteria,2TT0J@28211|Alphaproteobacteria,2JQ29@204441|Rhodospirillales 204441|Rhodospirillales E Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls dapE - 3.5.1.18 ko:K01439 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R02734 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20 k59_782594_1 765420.OSCT_2454 8.14e-86 272.0 COG1028@1|root,COG3347@1|root,COG1028@2|Bacteria,COG3347@2|Bacteria 2|Bacteria IQ Class II Aldolase and Adducin N-terminal domain - - - - - - - - - - - - Aldolase_II,adh_short,adh_short_C2 k59_612826_1 1267533.KB906741_gene547 2.38e-44 163.0 COG2010@1|root,COG4993@1|root,COG2010@2|Bacteria,COG4993@2|Bacteria 2|Bacteria G Dehydrogenase - - 1.1.5.2 ko:K00117 ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130 - R06620 RC00066 ko00000,ko00001,ko01000 - - - Cytochrome_CBB3,PQQ,PQQ_2 k59_782646_1 420324.KI912086_gene7293 1.3e-37 147.0 COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,1JR57@119045|Methylobacteriaceae 28211|Alphaproteobacteria T Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - AAA_16,DZR,Guanylate_cyc,SAM_1 k59_993284_1 640510.BC1001_1444 1.02e-150 438.0 COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,2VHPW@28216|Betaproteobacteria,1K55C@119060|Burkholderiaceae 28216|Betaproteobacteria P TIGRFAM chromate transporter, chromate ion transporter (CHR) family - - - ko:K07240 - - - - ko00000,ko02000 2.A.51.1 - - Chromate_transp k59_993284_2 522373.Smlt0160 1.19e-20 87.8 COG2032@1|root,COG2032@2|Bacteria,1N26J@1224|Proteobacteria,1S8WE@1236|Gammaproteobacteria,1XC3N@135614|Xanthomonadales 135614|Xanthomonadales P Destroys radicals which are normally produced within the cells and which are toxic to biological systems - - 1.15.1.1 ko:K04565 ko04146,ko04213,ko05014,ko05016,ko05020,map04146,map04213,map05014,map05016,map05020 - - - ko00000,ko00001,ko01000 - - - Sod_Cu k59_314501_1 265072.Mfla_0271 5.21e-28 105.0 COG0222@1|root,COG0222@2|Bacteria,1RGU4@1224|Proteobacteria,2VSG7@28216|Betaproteobacteria,2KMX6@206350|Nitrosomonadales 206350|Nitrosomonadales J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation rplL - - ko:K02935 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L12,Ribosomal_L12_N k59_314501_2 1095769.CAHF01000004_gene2749 7.95e-48 170.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,2VHF3@28216|Betaproteobacteria,472V5@75682|Oxalobacteraceae 28216|Betaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_396371_1 1217718.ALOU01000016_gene3157 5.87e-22 100.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VNZF@28216|Betaproteobacteria,1K34S@119060|Burkholderiaceae 28216|Betaproteobacteria C L-carnitine dehydratase bile acid-inducible protein F caiB - - - - - - - - - - - CoA_transf_3 k59_1081720_1 264198.Reut_C6290 3.83e-39 132.0 COG3293@1|root,COG3293@2|Bacteria,1N8GF@1224|Proteobacteria,2WESM@28216|Betaproteobacteria,1KB9H@119060|Burkholderiaceae 28216|Betaproteobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1_2 k59_1081720_2 94624.Bpet1403 9.96e-72 218.0 COG3293@1|root,COG3293@2|Bacteria,1N0VW@1224|Proteobacteria 1224|Proteobacteria L Transposase - - - - - - - - - - - - DDE_Tnp_1_2,DUF4096 k59_612871_1 1090319.KE386571_gene672 8.28e-28 111.0 COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,2U401@28211|Alphaproteobacteria,2K3DC@204457|Sphingomonadales 204457|Sphingomonadales L Transposase domain (DUF772) - - - ko:K07481 - - - - ko00000 - - - DDE_Tnp_1,DUF772 k59_314523_1 990285.RGCCGE502_02176 2.94e-32 122.0 COG0265@1|root,COG0265@2|Bacteria,1MURF@1224|Proteobacteria,2TUVW@28211|Alphaproteobacteria,4B76P@82115|Rhizobiaceae 28211|Alphaproteobacteria O Trypsin-like peptidase domain MA20_20705 - - - - - - - - - - - PDZ_2,Trypsin_2 k59_612895_1 1449353.JQMQ01000004_gene6255 3.09e-43 151.0 COG2050@1|root,COG2050@2|Bacteria,2HT7R@201174|Actinobacteria,2NND7@228398|Streptacidiphilus 201174|Actinobacteria Q Thioesterase-like superfamily - - - - - - - - - - - - 4HBT_3 k59_737696_1 535289.Dtpsy_2124 2.65e-54 183.0 COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2VK9J@28216|Betaproteobacteria,4AB5J@80864|Comamonadaceae 28216|Betaproteobacteria L PFAM transposase, IS4 family protein - - - - - - - - - - - - DDE_Tnp_1,DUF772 k59_225928_1 1238182.C882_2092 3.38e-80 247.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2TSC5@28211|Alphaproteobacteria,2JPQ5@204441|Rhodospirillales 204441|Rhodospirillales V ATPases associated with a variety of cellular activities - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_225928_2 314254.OA2633_09459 6.05e-05 45.4 COG5000@1|root,COG5000@2|Bacteria,1QYPI@1224|Proteobacteria,2TXUK@28211|Alphaproteobacteria,440TX@69657|Hyphomonadaceae 28211|Alphaproteobacteria T His Kinase A (phosphoacceptor) domain - - 2.7.13.3 ko:K15011 ko02020,map02020 M00523 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_139415_1 1121035.AUCH01000009_gene907 1.02e-48 166.0 COG1589@1|root,COG1589@2|Bacteria,1N0T7@1224|Proteobacteria,2VRMV@28216|Betaproteobacteria,2KW1D@206389|Rhodocyclales 206389|Rhodocyclales D Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly ftsQ - - ko:K03589 ko04112,map04112 - - - ko00000,ko00001,ko03036 - - - FtsQ,POTRA_1 k59_139415_2 1437824.BN940_16691 3.29e-37 135.0 COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,2VGZP@28216|Betaproteobacteria,3T2G8@506|Alcaligenaceae 28216|Betaproteobacteria D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring ftsA - - ko:K03590 ko04112,map04112 - - - ko00000,ko00001,ko03036,ko04812 - - - FtsA,SHS2_FTSA k59_524660_2 1249627.D779_0150 2.77e-68 216.0 COG1230@1|root,COG1230@2|Bacteria,1MUSS@1224|Proteobacteria,1S1S4@1236|Gammaproteobacteria,1WYWT@135613|Chromatiales 135613|Chromatiales P cation efflux - - - - - - - - - - - - Cation_efflux k59_524660_3 379731.PST_0663 1.5e-17 77.4 COG0789@1|root,COG0789@2|Bacteria,1MZ3P@1224|Proteobacteria,1S8VE@1236|Gammaproteobacteria,1Z3E9@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria K MerR, DNA binding cadR - - - - - - - - - - - MerR,MerR-DNA-bind,MerR_1 k59_58470_1 460265.Mnod_0806 8.87e-69 216.0 COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,2TRYS@28211|Alphaproteobacteria,1JT04@119045|Methylobacteriaceae 28211|Alphaproteobacteria I Belongs to the enoyl-CoA hydratase isomerase family - - 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_993418_1 935848.JAEN01000020_gene63 2.31e-98 300.0 COG1250@1|root,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2TSGF@28211|Alphaproteobacteria,2PWNB@265|Paracoccus 28211|Alphaproteobacteria I 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain - - 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 - R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 - - - 3HCDH,3HCDH_N k59_1081871_1 467661.RKLH11_4136 1.89e-75 236.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TSGZ@28211|Alphaproteobacteria,3ZI2P@58840|unclassified Rhodobacteraceae 28211|Alphaproteobacteria L L COG3547 Transposase and inactivated derivatives - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_1164063_1 438753.AZC_0470 3.91e-10 65.9 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TTM5@28211|Alphaproteobacteria,3EYK0@335928|Xanthobacteraceae 28211|Alphaproteobacteria C Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR). Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate - - 2.8.3.16 ko:K07749 - - - - ko00000,ko01000 - - - CoA_transf_3 k59_267499_1 452638.Pnec_1225 9.68e-40 144.0 COG0730@1|root,COG0730@2|Bacteria,1R3V4@1224|Proteobacteria,2VKXN@28216|Betaproteobacteria,1K5U1@119060|Burkholderiaceae 28216|Betaproteobacteria S membrane transporter protein - - - ko:K07090 - - - - ko00000 - - - TauE k59_356593_1 396588.Tgr7_1023 2.23e-32 114.0 COG4327@1|root,COG4327@2|Bacteria 2|Bacteria S Domain of unknown function (DUF4212) - - - ko:K14393 - - - - ko00000,ko02000 2.A.21.7 - - DUF4212 k59_356593_2 859653.HIMB5_00014010 5.36e-07 50.4 COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,2TTA4@28211|Alphaproteobacteria,4BPV6@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family yjcG - - ko:K14393 - - - - ko00000,ko02000 2.A.21.7 - - DUF4212,SSF k59_58518_1 1521187.JPIM01000074_gene2856 2.33e-54 186.0 COG1012@1|root,COG1012@2|Bacteria,2G5JE@200795|Chloroflexi,375BH@32061|Chloroflexia 32061|Chloroflexia C Belongs to the aldehyde dehydrogenase family - - - - - - - - - - - - Aldedh k59_1291435_1 757424.Hsero_2798 7.45e-98 294.0 COG1960@1|root,COG1960@2|Bacteria,1MVAH@1224|Proteobacteria,2VKD1@28216|Betaproteobacteria,475B2@75682|Oxalobacteraceae 28216|Betaproteobacteria I Acyl-CoA dehydrogenase, C-terminal domain acd12 - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_864024_2 1002340.AFCF01000032_gene3694 1.62e-12 63.2 2E5T0@1|root,330HC@2|Bacteria,1N7GC@1224|Proteobacteria,2UHV0@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_652309_1 871968.DESME_03395 4.69e-09 57.0 COG4974@1|root,COG4974@2|Bacteria,1TR57@1239|Firmicutes,24ACW@186801|Clostridia,26128@186807|Peptococcaceae 186801|Clostridia L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_int_SAM_4,Phage_integrase k59_1291447_1 1304878.AUGD01000001_gene195 2.45e-120 352.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,3K066@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - DEDD_Tnp_IS110 k59_143026_2 395495.Lcho_2150 1.27e-60 200.0 COG0674@1|root,COG0674@2|Bacteria,1MVM0@1224|Proteobacteria,2VJSA@28216|Betaproteobacteria,1KK3S@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Pyruvate:ferredoxin oxidoreductase core domain II porA - 1.2.7.1 ko:K00169 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR_N k59_656146_1 1131266.ARWQ01000004_gene1463 1.71e-34 124.0 COG1339@1|root,arCOG01904@2157|Archaea,41SG9@651137|Thaumarchaeota 651137|Thaumarchaeota H Domain of unknown function DUF120 - - 2.7.1.161 ko:K07732 ko00740,ko01100,map00740,map01100 - R08574 RC00002,RC00017 ko00000,ko00001,ko01000 - - - CTP-dep_RFKase k59_656146_2 1229909.NSED_07215 2.1e-52 175.0 COG0358@1|root,arCOG04281@2157|Archaea,41S75@651137|Thaumarchaeota 651137|Thaumarchaeota L DNA primase dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - Toprim_4 k59_1210849_1 864051.BurJ1DRAFT_1463 4.38e-100 298.0 COG1099@1|root,COG1099@2|Bacteria,1MY2H@1224|Proteobacteria,2VJVP@28216|Betaproteobacteria 28216|Betaproteobacteria S TatD related DNase - - - ko:K07051 - - - - ko00000 - - - TatD_DNase k59_741919_1 85643.Tmz1t_0712 2.68e-27 104.0 COG1546@1|root,COG1546@2|Bacteria,1RH2Y@1224|Proteobacteria,2VSQF@28216|Betaproteobacteria,2KWIK@206389|Rhodocyclales 206389|Rhodocyclales S Belongs to the CinA family - - 3.5.1.42 ko:K03743 ko00760,map00760 - R02322 RC00100 ko00000,ko00001,ko01000 - - - CinA k59_741919_2 1095769.CAHF01000013_gene3240 6.45e-28 106.0 COG1267@1|root,COG1267@2|Bacteria,1MZJA@1224|Proteobacteria,2VSP2@28216|Betaproteobacteria,4744W@75682|Oxalobacteraceae 28216|Betaproteobacteria I Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) pgpA - 3.1.3.27 ko:K01095 ko00564,ko01100,map00564,map01100 - R02029 RC00017 ko00000,ko00001,ko01000 - - - PgpA k59_187751_1 1500894.JQNN01000001_gene2805 3.93e-66 216.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,2VI3N@28216|Betaproteobacteria,472QU@75682|Oxalobacteraceae 28216|Betaproteobacteria J Ribonuclease E/G family cafA - - ko:K08301 - - - - ko00000,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_741942_1 243231.GSU1193 1.06e-73 234.0 COG0191@1|root,COG0191@2|Bacteria,1NMAK@1224|Proteobacteria,42NPW@68525|delta/epsilon subdivisions,2WIMN@28221|Deltaproteobacteria,43T4V@69541|Desulfuromonadales 28221|Deltaproteobacteria G Fructose-bisphosphate aldolase class-II - - 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - F_bP_aldolase k59_1123144_1 748658.KB907319_gene774 6.11e-16 81.6 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1S1NC@1236|Gammaproteobacteria,1X06R@135613|Chromatiales 135613|Chromatiales T Sigma-54 interaction domain - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_656218_1 1187851.A33M_0441 8.95e-73 229.0 COG1237@1|root,COG1237@2|Bacteria,1NK2I@1224|Proteobacteria,2TTSG@28211|Alphaproteobacteria 28211|Alphaproteobacteria S beta-lactamase - - 2.5.1.105 ko:K06897 ko00790,map00790 - R10339 RC00121 ko00000,ko00001,ko01000 - - - Lactamase_B k59_63686_1 748247.AZKH_1497 1.97e-27 102.0 2E1DK@1|root,32WSU@2|Bacteria,1N3VJ@1224|Proteobacteria,2VV0D@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_63686_2 640512.BC1003_4748 3.84e-38 142.0 COG1387@1|root,COG1387@2|Bacteria,1MYXV@1224|Proteobacteria,2VJIQ@28216|Betaproteobacteria,1K4RW@119060|Burkholderiaceae 28216|Betaproteobacteria L DNA polymerase - - - ko:K02347 - - - - ko00000,ko03400 - - - DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP k59_1044657_1 489825.LYNGBM3L_63180 3.99e-05 45.4 COG0577@1|root,COG0577@2|Bacteria,1G0Z7@1117|Cyanobacteria,1H9BF@1150|Oscillatoriales 1117|Cyanobacteria V FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1044657_2 864051.BurJ1DRAFT_4019 7.46e-123 355.0 COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,2VJ7G@28216|Betaproteobacteria,1KJCW@119065|unclassified Burkholderiales 28216|Betaproteobacteria V ATPases associated with a variety of cellular activities - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1044657_3 1121434.AULY01000007_gene1368 3.83e-23 102.0 COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,42KZW@68525|delta/epsilon subdivisions,2WIQB@28221|Deltaproteobacteria,2M9BI@213115|Desulfovibrionales 28221|Deltaproteobacteria C CoA-binding domain protein - - - ko:K09181 - - - - ko00000 - - - ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig k59_319897_1 94624.Bpet4348 3.96e-68 230.0 COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2VHCG@28216|Betaproteobacteria,3T6RJ@506|Alcaligenaceae 28216|Betaproteobacteria C 4Fe-4S dicluster domain - - - - - - - - - - - - CCG,FAD-oxidase_C,FAD_binding_4,Fer4_8 k59_997592_1 999141.GME_16937 2.42e-58 206.0 COG0501@1|root,COG0501@2|Bacteria,1MVU4@1224|Proteobacteria,1RPJ5@1236|Gammaproteobacteria,1XHE3@135619|Oceanospirillales 135619|Oceanospirillales O COG0501 Zn-dependent protease with chaperone function - - - - - - - - - - - - Peptidase_M48 k59_912603_1 1121033.AUCF01000001_gene2294 7.54e-83 251.0 COG0047@1|root,COG0047@2|Bacteria,1MU4Y@1224|Proteobacteria,2TS67@28211|Alphaproteobacteria,2JPBQ@204441|Rhodospirillales 204441|Rhodospirillales F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purQ - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - GATase_5 k59_443678_1 204773.HEAR2799 1.63e-60 196.0 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,2VKR8@28216|Betaproteobacteria,4735M@75682|Oxalobacteraceae 28216|Betaproteobacteria M Peptidase family M23 - - 3.4.24.75 ko:K08259 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_M23 k59_488857_1 1380390.JIAT01000011_gene2348 4.99e-55 194.0 COG1366@1|root,COG2409@1|root,COG1366@2|Bacteria,COG2409@2|Bacteria,2GJ5A@201174|Actinobacteria,4CR8Y@84995|Rubrobacteria 84995|Rubrobacteria T MMPL family - - - - - - - - - - - - MMPL,STAS_2 k59_571796_1 1123247.AUIJ01000008_gene2620 2.69e-05 45.1 COG2872@1|root,COG2872@2|Bacteria,1MY0P@1224|Proteobacteria,2TRRW@28211|Alphaproteobacteria 28211|Alphaproteobacteria S metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain alaS2 GO:0000049,GO:0002161,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0097159,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K07050 - - - - ko00000,ko01000,ko03016 - - - tRNA-synt_2c,tRNA_SAD k59_702082_1 216591.BCAL2105 1.34e-17 87.0 COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,2VKYV@28216|Betaproteobacteria,1K09C@119060|Burkholderiaceae 28216|Betaproteobacteria I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol clsA - - ko:K06131 ko00564,ko01100,map00564,map01100 - R07390 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2,PLDc_N k59_1297849_2 1313172.YM304_27420 6.95e-60 197.0 COG0821@1|root,COG0821@2|Bacteria,2GK2S@201174|Actinobacteria,4CMRA@84992|Acidimicrobiia 84992|Acidimicrobiia I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate ispG - 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 - - - GcpE k59_22047_1 1278307.KB907022_gene824 3.39e-14 72.8 COG1972@1|root,COG1972@2|Bacteria,1MXXX@1224|Proteobacteria,1RMBX@1236|Gammaproteobacteria,2QHED@267894|Psychromonadaceae 1236|Gammaproteobacteria P Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family yeiM GO:0003674,GO:0005215,GO:0005337,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0015858,GO:0015931,GO:0015932,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:1901264,GO:1901505,GO:1901642 - ko:K03317 - - - - ko00000 2.A.41 - - Gate,Nucleos_tra2_C,Nucleos_tra2_N k59_22047_2 1120941.AUBL01000010_gene420 1.86e-24 99.4 COG2078@1|root,COG2078@2|Bacteria,2ISCW@201174|Actinobacteria,4D5I2@85005|Actinomycetales 201174|Actinobacteria S AMMECR1 - - - ko:K06990 - - - - ko00000,ko04812 - - - AMMECR1,Memo k59_22053_1 1163617.SCD_n00016 1.95e-91 275.0 COG1432@1|root,COG1432@2|Bacteria,1MX5C@1224|Proteobacteria,2VK44@28216|Betaproteobacteria 28216|Betaproteobacteria NU NYN domain - - - - - - - - - - - - NYN,OST-HTH k59_22053_2 1121035.AUCH01000008_gene1117 3.44e-26 106.0 COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,2VI3M@28216|Betaproteobacteria,2KVC9@206389|Rhodocyclales 206389|Rhodocyclales E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine lysA - 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_1297885_1 583345.Mmol_0029 2.1e-09 66.6 COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,2VI5J@28216|Betaproteobacteria,2KMI1@206350|Nitrosomonadales 206350|Nitrosomonadales M PFAM AsmA family - - - ko:K07289 - - - - ko00000 - - - AsmA,AsmA_2 k59_145485_1 46429.BV95_03758 0.000667 41.6 COG1024@1|root,COG1024@2|Bacteria,1MVPQ@1224|Proteobacteria,2TTJ4@28211|Alphaproteobacteria,2K20K@204457|Sphingomonadales 204457|Sphingomonadales I enoyl-CoA hydratase - - - - - - - - - - - - ECH_1 k59_145485_2 1121861.KB899945_gene3974 1.54e-58 202.0 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs MA20_27485 - 1.2.5.3 ko:K03520 - - R11168 RC02800 ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_1000229_1 765914.ThisiDRAFT_1039 3.53e-64 216.0 COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,1RMQI@1236|Gammaproteobacteria,1WWD1@135613|Chromatiales 135613|Chromatiales K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth rpoD - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_531639_1 511062.GU3_10535 3.5e-16 82.4 COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1MW7X@1224|Proteobacteria,1RRF4@1236|Gammaproteobacteria,1Y3VF@135624|Aeromonadales 135624|Aeromonadales L DDE superfamily endonuclease - - - - - - - - - - - - DDE_3,HTH_23,HTH_32,HTH_33 k59_1125516_1 580332.Slit_0533 1.41e-60 207.0 COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,2VJ72@28216|Betaproteobacteria 28216|Betaproteobacteria T Adenylyl cyclase class-3 4 guanylyl cyclase cyaA - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CHASE2,Guanylate_cyc k59_870016_1 59538.XP_005959125.1 9.34e-12 63.9 COG0443@1|root,KOG0102@2759|Eukaryota,38EJA@33154|Opisthokonta,3BABY@33208|Metazoa,3CT5K@33213|Bilateria,48BEX@7711|Chordata,48XVF@7742|Vertebrata,3JAJ8@40674|Mammalia,4IZNM@91561|Cetartiodactyla 33154|Opisthokonta O Heat shock 70 kDa protein - - - - - - - - - - - - HSP70 k59_870016_2 420662.Mpe_A2497 1.18e-36 133.0 COG0576@1|root,COG0576@2|Bacteria,1RH8T@1224|Proteobacteria,2VSEQ@28216|Betaproteobacteria,1KKZ2@119065|unclassified Burkholderiales 28216|Betaproteobacteria O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ grpE - - ko:K03687 - - - - ko00000,ko03029,ko03110 - - - GrpE k59_1297933_1 319003.Bra1253DRAFT_06974 2.24e-38 142.0 COG1960@1|root,COG1960@2|Bacteria,1MXMQ@1224|Proteobacteria,2TTF6@28211|Alphaproteobacteria,3JV1J@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I Acyl-CoA dehydrogenase, C-terminal domain MA20_38220 - 1.14.14.12 ko:K16047 ko00984,ko01100,ko01120,map00984,map01100,map01120 - R09819 RC00236 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_2,Acyl-CoA_dh_N k59_1297933_2 555793.WSK_3743 8.82e-11 62.4 COG0346@1|root,COG0346@2|Bacteria 2|Bacteria E lactoylglutathione lyase activity - - - ko:K08234 - - - - ko00000 - - - Glyoxalase,Glyoxalase_4 k59_273613_1 398525.KB900701_gene5932 2.62e-44 163.0 COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,3JTQ7@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - AAA_16,DZR,Guanylate_cyc,SAM_1 k59_621403_1 1122939.ATUD01000022_gene3671 2.89e-18 88.6 COG1208@1|root,COG1208@2|Bacteria,2GKTE@201174|Actinobacteria,4CPFB@84995|Rubrobacteria 84995|Rubrobacteria JM Nucleotidyl transferase - - 2.7.7.13 ko:K00966 ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110 M00114,M00361,M00362 R00885 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transferase k59_531698_1 1178482.BJB45_03735 2.5e-09 57.0 COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,1RM89@1236|Gammaproteobacteria,1XHJY@135619|Oceanospirillales 135619|Oceanospirillales L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL - - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C k59_531698_2 211165.AJLN01000100_gene4105 1.48e-115 338.0 COG1028@1|root,COG1028@2|Bacteria,1G4KK@1117|Cyanobacteria 1117|Cyanobacteria IQ Short chain dehydrogenase - - - - - - - - - - - - adh_short_C2 k59_103162_1 278963.ATWD01000001_gene3210 3.09e-47 169.0 COG1506@1|root,COG1506@2|Bacteria,3Y357@57723|Acidobacteria 57723|Acidobacteria E PFAM Tannase and feruloyl esterase - - - - - - - - - - - - Tannase k59_1297979_1 1191523.MROS_1058 8.35e-33 132.0 COG1529@1|root,COG1529@2|Bacteria 2|Bacteria C xanthine dehydrogenase activity - - 1.3.99.16 ko:K07303 - - - - ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_1256476_1 395495.Lcho_1903 4.63e-74 229.0 COG0566@1|root,COG0566@2|Bacteria,1MWCM@1224|Proteobacteria,2VHF4@28216|Betaproteobacteria,1KJA3@119065|unclassified Burkholderiales 28216|Betaproteobacteria J Specifically methylates the ribose of guanosine 2251 in 23S rRNA rlmB - 2.1.1.185 ko:K03218 - - - - ko00000,ko01000,ko03009 - - - SpoU_methylase,SpoU_sub_bind k59_273667_1 292415.Tbd_0525 3.07e-41 144.0 COG2802@1|root,COG2802@2|Bacteria,1RFYH@1224|Proteobacteria,2VSA4@28216|Betaproteobacteria 28216|Betaproteobacteria S Peptidase S16, lon domain protein - - - ko:K07157 - - - - ko00000 - - - LON_substr_bdg k59_571953_1 497321.C664_19798 4.26e-242 681.0 COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,2VHS3@28216|Betaproteobacteria,2KV81@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction thiC - 4.1.99.17 ko:K03147 ko00730,ko01100,map00730,map01100 M00127 R03472 RC03251,RC03252 ko00000,ko00001,ko00002,ko01000 - - - ThiC-associated,ThiC_Rad_SAM k59_791584_1 546262.NEICINOT_03085 2.07e-58 196.0 COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,2VJIC@28216|Betaproteobacteria,2KPFP@206351|Neisseriales 206351|Neisseriales L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseA - 3.1.11.6 ko:K03601 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_L,tRNA_anti_2 k59_1090424_1 375286.mma_0396 6.65e-152 441.0 COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2VHKU@28216|Betaproteobacteria,476QA@75682|Oxalobacteraceae 28216|Betaproteobacteria S Tripartite tricarboxylate transporter TctA family - - - ko:K07793 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.80.1 - - TctA k59_1090424_2 312153.Pnuc_0636 0.000375 42.0 COG0664@1|root,COG0664@2|Bacteria,1R64V@1224|Proteobacteria,2VJXN@28216|Betaproteobacteria 28216|Betaproteobacteria T cyclic nucleotide-binding - - - - - - - - - - - - cNMP_binding k59_489110_1 1144343.PMI41_02642 1.4e-21 94.0 COG0702@1|root,COG0702@2|Bacteria,1QU1T@1224|Proteobacteria,2TTHK@28211|Alphaproteobacteria,43MYG@69277|Phyllobacteriaceae 28211|Alphaproteobacteria GM NAD dependent epimerase/dehydratase family - - - - - - - - - - - - Epimerase k59_489110_2 1123392.AQWL01000005_gene2896 9.37e-45 153.0 COG1656@1|root,COG1656@2|Bacteria,1R442@1224|Proteobacteria,2VN8Q@28216|Betaproteobacteria,1KS9T@119069|Hydrogenophilales 119069|Hydrogenophilales S Mut7-C ubiquitin - - - ko:K09122 - - - - ko00000 - - - Mut7-C,Ub-Mut7C k59_791600_1 991905.SL003B_2913 4.79e-106 310.0 COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,2TSV8@28211|Alphaproteobacteria,4BRES@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria T Transcriptional regulatory protein, C terminal feuP - - ko:K02483 - - - - ko00000,ko02022 - - - Response_reg,Trans_reg_C k59_145652_1 457398.HMPREF0326_00313 5.44e-07 51.6 COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,42M32@68525|delta/epsilon subdivisions,2WJA4@28221|Deltaproteobacteria,2M7RC@213115|Desulfovibrionales 28221|Deltaproteobacteria S Tripartite tricarboxylate transporter TctA family - - - ko:K07793 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.80.1 - - TctA k59_145652_2 1005048.CFU_1999 7.36e-31 122.0 COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,2VKIR@28216|Betaproteobacteria,473NB@75682|Oxalobacteraceae 28216|Betaproteobacteria E Bacterial NAD-glutamate dehydrogenase gdhB - 1.4.1.2 ko:K15371 ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100 - R00243 RC00006,RC02799 ko00000,ko00001,ko01000 - - - Bac_GDH k59_791610_2 78245.Xaut_0799 4.56e-15 73.9 2DM35@1|root,31I40@2|Bacteria,1N0D2@1224|Proteobacteria,2TWGH@28211|Alphaproteobacteria 28211|Alphaproteobacteria S MerT mercuric transport protein - - - ko:K08363 - - - - ko00000,ko02000 1.A.72.1 - - MerT k59_1345868_1 396588.Tgr7_0594 2.61e-53 184.0 28HC9@1|root,2Z7P5@2|Bacteria,1R4BH@1224|Proteobacteria,1RSAN@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1171164_2 159087.Daro_0853 3.06e-84 262.0 COG1752@1|root,COG1752@2|Bacteria,1PIHH@1224|Proteobacteria,2VHKX@28216|Betaproteobacteria,2KUYE@206389|Rhodocyclales 206389|Rhodocyclales S esterase of the alpha-beta hydrolase superfamily - - - ko:K07001 - - - - ko00000 - - - Patatin k59_1000434_1 391625.PPSIR1_08217 4.91e-62 202.0 COG0057@1|root,COG0057@2|Bacteria,1N2N1@1224|Proteobacteria 1224|Proteobacteria G Glyceraldehyde-3-phosphate dehydrogenase - - 1.2.1.59 ko:K00150 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166 R01061,R01063 RC00149 ko00000,ko00001,ko00002,ko01000 - - - DapB_N,Gp_dh_C k59_1262105_1 1380355.JNIJ01000128_gene810 3.61e-25 101.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TSGZ@28211|Alphaproteobacteria,3JUDN@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L IS116 IS110 IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_963451_1 1122613.ATUP01000001_gene1882 1.56e-83 265.0 COG2978@1|root,COG2978@2|Bacteria,1MUJ1@1224|Proteobacteria,2U1AP@28211|Alphaproteobacteria,43WAR@69657|Hyphomonadaceae 28211|Alphaproteobacteria H AbgT putative transporter family - - - ko:K12942 - - - - ko00000 - - - ABG_transport k59_1351412_1 1205680.CAKO01000010_gene3927 5.7e-82 256.0 COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,2TRTJ@28211|Alphaproteobacteria,2JR9Q@204441|Rhodospirillales 204441|Rhodospirillales P Di-haem cytochrome c peroxidase - - 1.11.1.5 ko:K00428 - - - - ko00000,ko01000 - - - CCP_MauG,Cytochrom_C k59_1351420_1 1000565.METUNv1_02457 2.21e-88 275.0 COG2206@1|root,COG3437@1|root,COG2206@2|Bacteria,COG3437@2|Bacteria,1MV37@1224|Proteobacteria,2VJ21@28216|Betaproteobacteria,2KVJ8@206389|Rhodocyclales 206389|Rhodocyclales T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - 3.1.4.17 ko:K01120 ko00230,map00230 - R00191,R01234 RC00296 ko00000,ko00001,ko01000 - - - FHA,GAF,HD,HD_5 k59_1054636_2 1121935.AQXX01000130_gene2425 2.33e-35 125.0 2AD08@1|root,312N7@2|Bacteria,1NDC4@1224|Proteobacteria,1SAPT@1236|Gammaproteobacteria,1XQHK@135619|Oceanospirillales 135619|Oceanospirillales S Holin of 3TMs, for gene-transfer release - - - - - - - - - - - - GTA_holin_3TM k59_452127_1 1266925.JHVX01000004_gene1276 1.01e-106 335.0 COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,2VKDZ@28216|Betaproteobacteria,371SX@32003|Nitrosomonadales 28216|Betaproteobacteria C Aconitase C-terminal domain acnA - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_1304055_2 290398.Csal_0168 4.05e-40 138.0 COG3476@1|root,COG3476@2|Bacteria,1MZC1@1224|Proteobacteria,1S879@1236|Gammaproteobacteria,1XPHB@135619|Oceanospirillales 135619|Oceanospirillales T TspO/MBR family - - - ko:K05770 ko04080,ko04214,ko04979,ko05166,map04080,map04214,map04979,map05166 - - - ko00000,ko00001,ko02000 9.A.24 - - TspO_MBR k59_108834_1 1476876.JOJO01000008_gene2748 2.63e-18 88.2 COG2159@1|root,COG2159@2|Bacteria,2HEB4@201174|Actinobacteria 201174|Actinobacteria CH amidohydrolase - - 4.1.1.45,4.1.1.52 ko:K03392,ko:K22213 ko00380,ko01100,map00380,map01100 M00038 R04323 RC00779 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_2 k59_108838_1 1121106.JQKB01000037_gene663 3.01e-25 103.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,2JQAV@204441|Rhodospirillales 204441|Rhodospirillales C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_108838_2 34740.HMEL010504-PA 8.27e-08 53.1 COG2303@1|root,KOG1238@2759|Eukaryota,38UEK@33154|Opisthokonta,3BBXZ@33208|Metazoa,3CRXP@33213|Bilateria,41U7M@6656|Arthropoda,3SGW5@50557|Insecta,44944@7088|Lepidoptera 33208|Metazoa E GMC oxidoreductase - GO:0002165,GO:0003674,GO:0003824,GO:0006629,GO:0007275,GO:0008150,GO:0008152,GO:0008202,GO:0009791,GO:0009987,GO:0010817,GO:0016491,GO:0032501,GO:0032502,GO:0034754,GO:0042180,GO:0042445,GO:0044237,GO:0044238,GO:0044281,GO:0045455,GO:0048856,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:1901360 1.1.3.49 ko:K21270 - - - - ko00000,ko01000 - - - GMC_oxred_C,GMC_oxred_N k59_1130640_1 880072.Desac_2715 2.82e-16 80.1 COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,42NPG@68525|delta/epsilon subdivisions,2WJVP@28221|Deltaproteobacteria,2MREM@213462|Syntrophobacterales 28221|Deltaproteobacteria M Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxA - 2.3.1.129 ko:K00677 ko00540,ko01100,ko01503,map00540,map01100,map01503 M00060 R04567 RC00039,RC00055 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Acetyltransf_11,Hexapep k59_1130640_2 861299.J421_3221 2.24e-16 78.6 COG0764@1|root,COG0774@1|root,COG0764@2|Bacteria,COG0774@2|Bacteria,1ZT4Z@142182|Gemmatimonadetes 142182|Gemmatimonadetes IM Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis fabZ - 3.5.1.108,4.2.1.59 ko:K16363 ko00061,ko00540,ko01100,ko01212,map00061,map00540,map01100,map01212 M00060,M00083 R04428,R04535,R04537,R04544,R04568,R04587,R04954,R04965 RC00166,RC00300,RC00831,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004,ko01005 - - - FabA,LpxC k59_1304071_1 1121127.JAFA01000033_gene4547 5.1e-07 52.0 COG3213@1|root,COG3213@2|Bacteria,1MUJK@1224|Proteobacteria,2VJ75@28216|Betaproteobacteria,1K5JW@119060|Burkholderiaceae 28216|Betaproteobacteria P PFAM NnrS family protein - - - ko:K07234 - - - - ko00000 - - - NnrS k59_1304071_2 1278309.KB907106_gene1345 9.11e-34 119.0 COG3094@1|root,COG3094@2|Bacteria,1MZN6@1224|Proteobacteria,1S70H@1236|Gammaproteobacteria,1XKFQ@135619|Oceanospirillales 135619|Oceanospirillales S Invasion gene expression up-regulator - - - - - - - - - - - - SirB k59_750512_1 757424.Hsero_2774 6.71e-39 149.0 COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1MUKF@1224|Proteobacteria,2VHKP@28216|Betaproteobacteria,4737H@75682|Oxalobacteraceae 28216|Betaproteobacteria S Competence protein comA - - ko:K02238 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - Competence,DUF4131,Lactamase_B k59_665186_1 652103.Rpdx1_4127 8.05e-60 200.0 COG1924@1|root,COG1924@2|Bacteria,1R411@1224|Proteobacteria,2U1DN@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Benzoyl-CoA reductase subunit - - 1.3.7.8 ko:K04114 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00541 R02451 RC00002,RC01839 ko00000,ko00001,ko00002,ko01000 - - - BcrAD_BadFG k59_238826_1 1234595.C725_2406 2.73e-78 246.0 COG0564@1|root,COG0564@2|Bacteria,1MVDX@1224|Proteobacteria,2TTQC@28211|Alphaproteobacteria,4BQ6P@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria J Responsible for synthesis of pseudouridine from uracil rluC GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.24 ko:K06179 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_963549_1 1123255.JHYS01000012_gene1298 9.34e-10 55.8 COG4453@1|root,COG4453@2|Bacteria,1N7K8@1224|Proteobacteria,2VTUT@28216|Betaproteobacteria,4AG47@80864|Comamonadaceae 28216|Betaproteobacteria S Protein of unknown function (DUF1778) - - - - - - - - - - - - DUF1778 k59_963549_2 1392838.AWNM01000075_gene384 2.99e-36 133.0 COG2084@1|root,COG2084@2|Bacteria,1MV48@1224|Proteobacteria,2VPIY@28216|Betaproteobacteria,3T6QH@506|Alcaligenaceae 28216|Betaproteobacteria C NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - - - - - - - - - - - NAD_binding_11,NAD_binding_2 k59_371012_1 292415.Tbd_2366 1.36e-58 190.0 COG4582@1|root,COG4582@2|Bacteria,1MW69@1224|Proteobacteria,2VIIG@28216|Betaproteobacteria,1KRM9@119069|Hydrogenophilales 119069|Hydrogenophilales D Cell division protein - - - ko:K18778 - - - - ko00000,ko03036 - - - ZapD k59_1176840_1 159087.Daro_2379 1e-66 221.0 COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,2VJZD@28216|Betaproteobacteria,2KU9G@206389|Rhodocyclales 206389|Rhodocyclales H Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD - - - - - - - - - - - Carb_kinase,YjeF_N k59_628134_2 269796.Rru_A1751 7.33e-73 228.0 COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,2TSDS@28211|Alphaproteobacteria,2JQSZ@204441|Rhodospirillales 204441|Rhodospirillales E Belongs to the binding-protein-dependent transport system permease family livH - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_494766_2 1469245.JFBG01000057_gene2376 1.33e-30 117.0 COG4665@1|root,COG4665@2|Bacteria,1RG47@1224|Proteobacteria,1S3PZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q TRAP-type mannitol chloroaromatic compound transport system small permease component - - - - - - - - - - - - DctQ k59_1262240_1 349521.HCH_05382 1.06e-53 184.0 COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,1RN7V@1236|Gammaproteobacteria,1XHR4@135619|Oceanospirillales 135619|Oceanospirillales S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis hflX - - ko:K03665 - - - - ko00000,ko03009 - - - GTP-bdg_M,GTP-bdg_N,MMR_HSR1 k59_963587_1 159087.Daro_3142 5.38e-25 102.0 COG2003@1|root,COG2003@2|Bacteria,1MXZ5@1224|Proteobacteria,2VKTW@28216|Betaproteobacteria,2KUXZ@206389|Rhodocyclales 206389|Rhodocyclales E Belongs to the UPF0758 family radC - - ko:K03630 - - - - ko00000 - - - RadC k59_279378_1 1280953.HOC_17030 7.66e-74 236.0 COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2TQKF@28211|Alphaproteobacteria 28211|Alphaproteobacteria L COG4584 Transposase and inactivated derivatives - - - - - - - - - - - - rve k59_665298_1 977880.RALTA_A1817 5.19e-129 375.0 COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,2VI71@28216|Betaproteobacteria,1K25Z@119060|Burkholderiaceae 28216|Betaproteobacteria P Phosphate transporter pit - - ko:K03306 - - - - ko00000 2.A.20 - - PHO4 k59_452293_1 575540.Isop_0508 7.86e-37 141.0 COG0367@1|root,COG0367@2|Bacteria,2IXAI@203682|Planctomycetes 203682|Planctomycetes E Asparagine synthase, glutamine-hydrolyzing - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_1304210_1 483219.LILAB_29355 1.95e-12 67.8 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42M6C@68525|delta/epsilon subdivisions,2WM3G@28221|Deltaproteobacteria,2YV02@29|Myxococcales 28221|Deltaproteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,Response_reg k59_1304210_2 637390.AFOH01000013_gene746 3.68e-17 84.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,2NCKS@225057|Acidithiobacillales 225057|Acidithiobacillales T Bacterial regulatory protein, Fis family - - - ko:K07714 ko02020,map02020 M00500 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_1304210_3 1163617.SCD_n01316 2.48e-48 168.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,2VM1X@28216|Betaproteobacteria 28216|Betaproteobacteria U General secretion pathway protein F gspF - - ko:K02455 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSF k59_327763_1 382245.ASA_1070 4.26e-17 85.5 COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,1RM8M@1236|Gammaproteobacteria,1Y3M1@135624|Aeromonadales 135624|Aeromonadales M Transfers the fatty acyl group on membrane lipoproteins lnt - - ko:K03820 - - - - ko00000,ko01000 - GT2 - CN_hydrolase k59_1262353_1 570967.JMLV01000009_gene1056 6.07e-91 278.0 COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,2TQKT@28211|Alphaproteobacteria,2JQ46@204441|Rhodospirillales 204441|Rhodospirillales E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT k59_537534_1 1223521.BBJX01000006_gene1789 1.41e-22 99.0 COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,2VKFT@28216|Betaproteobacteria,4ABEC@80864|Comamonadaceae 28216|Betaproteobacteria K response regulator lytT - - - - - - - - - - - LytTR,Response_reg k59_494905_1 1316936.K678_04221 5.81e-80 248.0 COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,2TSJQ@28211|Alphaproteobacteria,2JPIB@204441|Rhodospirillales 204441|Rhodospirillales E Belongs to the binding-protein-dependent transport system permease family - - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_1351662_1 522306.CAP2UW1_2826 1.05e-103 322.0 COG0398@1|root,COG1249@1|root,COG0398@2|Bacteria,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2VH3T@28216|Betaproteobacteria,1KQAC@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria C SNARE associated Golgi protein merA - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim,SNARE_assoc k59_166628_1 292415.Tbd_2433 7.06e-101 313.0 COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,2VHPQ@28216|Betaproteobacteria,1KSEV@119069|Hydrogenophilales 119069|Hydrogenophilales E Peptidase family M3 - - 3.4.24.70 ko:K01414 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3 k59_166628_2 396588.Tgr7_0105 1.77e-05 51.6 COG2433@1|root,COG2433@2|Bacteria,1N0ZS@1224|Proteobacteria,1S7FF@1236|Gammaproteobacteria,1WYCM@135613|Chromatiales 135613|Chromatiales S Domain of unknown function (DUF4124) - - - - - - - - - - - - DUF4124 k59_765690_1 216594.MMAR_3216 4.36e-25 106.0 COG3407@1|root,COG3407@2|Bacteria,2GJEH@201174|Actinobacteria,23C8R@1762|Mycobacteriaceae 201174|Actinobacteria I Key enzyme in isoprenoid synthesis. converts (R)-5- diphosphomevalonate to phosphate isopentenyl diphosphate CO(2) mvaD - 4.1.1.33 ko:K01597 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00095 R01121 RC00453 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N k59_1021262_1 1120983.KB894575_gene528 6.81e-15 78.2 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,1JPNG@119043|Rhodobiaceae 28211|Alphaproteobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS_3,PAS_9,Response_reg,sCache_2 k59_510201_1 269796.Rru_A0335 8.13e-26 100.0 COG2606@1|root,COG2606@2|Bacteria,1RD82@1224|Proteobacteria,2U7H0@28211|Alphaproteobacteria 28211|Alphaproteobacteria S YbaK prolyl-tRNA synthetase associated ybaK - - - - - - - - - - - tRNA_edit k59_510202_1 502025.Hoch_0520 3.22e-34 126.0 COG1721@1|root,COG1721@2|Bacteria,1Q7RR@1224|Proteobacteria,43418@68525|delta/epsilon subdivisions,2X2J1@28221|Deltaproteobacteria,2Z08E@29|Myxococcales 28221|Deltaproteobacteria S Protein of unknown function DUF58 - - - - - - - - - - - - DUF58 k59_510202_2 314230.DSM3645_26884 1.61e-22 95.9 COG0714@1|root,COG0714@2|Bacteria,2IX23@203682|Planctomycetes 203682|Planctomycetes S PFAM ATPase family associated with various cellular activities (AAA) - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_1143882_1 296591.Bpro_1723 1.05e-37 140.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2VH4I@28216|Betaproteobacteria,4AAM8@80864|Comamonadaceae 28216|Betaproteobacteria L PFAM UvrD REP helicase uvrD - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_1143882_2 264198.Reut_B4611 1.28e-08 57.4 COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VKDI@28216|Betaproteobacteria,1KC3M@119060|Burkholderiaceae 28216|Betaproteobacteria S Tripartite tricarboxylate transporter family receptor - - - - - - - - - - - - TctC k59_765723_1 1283077.M1INZ1_9CAUD 5.83e-20 93.2 4QCM5@10239|Viruses,4QVZY@35237|dsDNA viruses no RNA stage,4QQFH@28883|Caudovirales,4QNDH@10744|Podoviridae 10744|Podoviridae S Bacteriophage head to tail connecting protein - GO:0005575,GO:0008150,GO:0016032,GO:0019012,GO:0019028,GO:0019058,GO:0019068,GO:0019072,GO:0019073,GO:0032991,GO:0044403,GO:0044419,GO:0044423,GO:0046798,GO:0051704 - - - - - - - - - - - k59_425640_1 85643.Tmz1t_3337 1.71e-75 231.0 COG0088@1|root,COG0088@2|Bacteria,1MXPF@1224|Proteobacteria,2VHS6@28216|Betaproteobacteria,2KVFP@206389|Rhodocyclales 206389|Rhodocyclales J 50S ribosomal protein L4 rplD - - ko:K02926 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L4 k59_1143897_2 1444712.BN1013_02408 2.92e-44 154.0 COG4834@1|root,COG4834@2|Bacteria 2|Bacteria S Uncharacterized protein conserved in bacteria (DUF2184) Z012_11565 - - - - - - - - - - - DUF2184 k59_723348_1 1000565.METUNv1_02596 9.02e-26 101.0 COG0723@1|root,COG0723@2|Bacteria,1MZ7A@1224|Proteobacteria,2VVI5@28216|Betaproteobacteria 28216|Betaproteobacteria C plastoquinol--plastocyanin reductase activity - - - - - - - - - - - - - k59_723348_2 1144342.PMI40_01561 6.93e-68 214.0 COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,2VIUV@28216|Betaproteobacteria,47247@75682|Oxalobacteraceae 28216|Betaproteobacteria O Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine aat - 2.3.2.6 ko:K00684 - - R03813,R11443,R11444 RC00055,RC00064 ko00000,ko01000 - - - Leu_Phe_trans k59_425668_1 279010.BL00393 3.95e-13 70.9 COG0266@1|root,COG0266@2|Bacteria,1TPM9@1239|Firmicutes,4H9Q7@91061|Bacilli,1ZCC9@1386|Bacillus 91061|Bacilli L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates fpg - 3.2.2.23,4.2.99.18 ko:K10563 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Fapy_DNA_glyco,H2TH,zf-FPG_IleRS k59_425668_2 1410631.JHWZ01000007_gene642 1.57e-11 65.9 COG0151@1|root,COG0151@2|Bacteria,1UHN9@1239|Firmicutes,25E76@186801|Clostridia,27I9F@186928|unclassified Lachnospiraceae 186801|Clostridia F Phosphoribosylglycinamide synthetase, C domain purD - 6.3.4.13 ko:K01945 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144 RC00090,RC00166 ko00000,ko00001,ko00002,ko01000 - - - GARS_A,GARS_C,GARS_N k59_1143959_1 713586.KB900536_gene1208 2.67e-62 214.0 COG4191@1|root,COG5000@1|root,COG4191@2|Bacteria,COG5000@2|Bacteria,1RCM9@1224|Proteobacteria,1RP53@1236|Gammaproteobacteria,1WZX9@135613|Chromatiales 135613|Chromatiales T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,Response_reg k59_978981_1 746697.Aeqsu_3225 1.5e-18 90.1 COG2866@1|root,COG3391@1|root,COG2866@2|Bacteria,COG3391@2|Bacteria,4NSJU@976|Bacteroidetes,1I4SR@117743|Flavobacteriia 976|Bacteroidetes E amine dehydrogenase activity - - - - - - - - - - - - - k59_211715_1 78245.Xaut_2905 8.8e-51 170.0 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2U0FG@28211|Alphaproteobacteria,3EZ6C@335928|Xanthobacteraceae 28211|Alphaproteobacteria L PFAM Integrase catalytic region - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve,rve_2 k59_1320150_1 296587.XP_002506201.1 2.5e-23 97.4 COG0235@1|root,KOG3699@2759|Eukaryota,37W8G@33090|Viridiplantae,34KQ0@3041|Chlorophyta 3041|Chlorophyta TZ Class II Aldolase and Adducin N-terminal domain - - - - - - - - - - - - Aldolase_II k59_467828_1 977880.RALTA_B1495 6.35e-95 303.0 COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,2VP2Q@28216|Betaproteobacteria,1K6SR@119060|Burkholderiaceae 28216|Betaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family fdhA1 - 1.17.1.9,1.17.99.7 ko:K00123,ko:K22015 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Fer2_4,Fer4,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_1021421_1 685035.ADAE01000003_gene2760 1.87e-48 175.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria 28211|Alphaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_467854_1 62928.azo1726 1.53e-92 293.0 COG0366@1|root,COG0366@2|Bacteria,1MWBZ@1224|Proteobacteria,2VK9R@28216|Betaproteobacteria,2KYHA@206389|Rhodocyclales 206389|Rhodocyclales F Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB - - 2.4.99.16 ko:K16147 ko00500,ko01100,map00500,map01100 - R09994 - ko00000,ko00001,ko01000 - GH13 - DUF3416 k59_593315_1 1217720.ALOX01000027_gene3734 1.06e-45 158.0 COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,2TRIG@28211|Alphaproteobacteria,2JP9M@204441|Rhodospirillales 204441|Rhodospirillales K transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate k59_166821_1 272568.GDI2142 3.54e-55 177.0 COG0764@1|root,COG0764@2|Bacteria,1RH2T@1224|Proteobacteria,2U7G4@28211|Alphaproteobacteria,2JS3T@204441|Rhodospirillales 204441|Rhodospirillales I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs fabZ - 4.2.1.59 ko:K02372 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121 RC00831,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FabA k59_765872_1 1379270.AUXF01000001_gene2303 4.4e-28 117.0 COG2304@1|root,COG5426@1|root,COG2304@2|Bacteria,COG5426@2|Bacteria,1ZUB1@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Putative glutamine amidotransferase - - - - - - - - - - - - GATase1_like k59_255049_1 1146883.BLASA_4410 1.29e-82 259.0 COG4799@1|root,COG4799@2|Bacteria,2GIRU@201174|Actinobacteria,4ERM7@85013|Frankiales 201174|Actinobacteria I Carboxyl transferase domain - - - - - - - - - - - - Carboxyl_trans k59_166880_1 666684.AfiDRAFT_1463 2.64e-95 292.0 COG1073@1|root,COG1765@1|root,COG1073@2|Bacteria,COG1765@2|Bacteria,1N2BT@1224|Proteobacteria,2TQN7@28211|Alphaproteobacteria,3JQSS@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria O OsmC-like protein MA20_16590 - - ko:K06889,ko:K07397 - - - - ko00000 - - - Hydrolase_4,OsmC k59_1277861_1 1121035.AUCH01000004_gene310 4.68e-14 77.4 COG2114@1|root,COG3629@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3629@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria 1224|Proteobacteria T Adenylate Guanylate cyclase - - - - - - - - - - - - AAA_16,BTAD,Guanylate_cyc k59_1235382_1 550540.Fbal_3714 1.01e-28 119.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria 1236|Gammaproteobacteria L it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction uvrD GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006289,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017116,GO:0022607,GO:0031297,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0042802,GO:0043142,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045005,GO:0046483,GO:0050896,GO:0051259,GO:0051260,GO:0051276,GO:0051716,GO:0065003,GO:0070035,GO:0070581,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_166918_1 857087.Metme_3221 7.45e-35 136.0 COG4249@1|root,COG4249@2|Bacteria,1QU7W@1224|Proteobacteria,1RZ8P@1236|Gammaproteobacteria,1XG8B@135618|Methylococcales 135618|Methylococcales S Peptidase C13 family - - - - - - - - - - - - Peptidase_C13 k59_1320302_1 1192124.LIG30_4938 6.21e-35 137.0 COG4258@1|root,COG4258@2|Bacteria,1MU1E@1224|Proteobacteria,2VHXY@28216|Betaproteobacteria,1K0YC@119060|Burkholderiaceae 28216|Betaproteobacteria S MMPL family - - - - - - - - - - - - MMPL k59_553057_1 1120983.KB894571_gene2655 3.02e-63 214.0 COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,2TQV8@28211|Alphaproteobacteria,1JNPY@119043|Rhodobiaceae 28211|Alphaproteobacteria J B3/4 domain pheT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5,FDX-ACB,tRNA_bind k59_255118_1 926569.ANT_04130 8.24e-66 219.0 COG2203@1|root,COG4585@1|root,COG2203@2|Bacteria,COG4585@2|Bacteria,2G8F9@200795|Chloroflexi 200795|Chloroflexi T histidine kinase, dimerisation and phosphoacceptor region - - - - - - - - - - - - GAF_2,GAF_3,HATPase_c,HisKA_3 k59_295129_1 479435.Kfla_4259 1.21e-35 129.0 COG2764@1|root,COG3832@1|root,COG2764@2|Bacteria,COG3832@2|Bacteria,2HUAQ@201174|Actinobacteria,4DU94@85009|Propionibacteriales 201174|Actinobacteria S glyoxalase bleomycin resistance protein dioxygenase - - - - - - - - - - - - - k59_295129_2 1120950.KB892757_gene6603 6.99e-38 130.0 COG0640@1|root,COG0640@2|Bacteria,2GS8K@201174|Actinobacteria,4DV3K@85009|Propionibacteriales 201174|Actinobacteria K helix_turn_helix, Arsenical Resistance Operon Repressor - - - - - - - - - - - - HTH_20,HTH_5 k59_1144168_2 305700.B447_13129 7.47e-54 186.0 COG2206@1|root,COG2206@2|Bacteria,1R3VR@1224|Proteobacteria,2VMY5@28216|Betaproteobacteria,2KVPZ@206389|Rhodocyclales 206389|Rhodocyclales T Domain of unknown function (DUF3391) - - - - - - - - - - - - DUF3391,HD_5 k59_1235497_1 395495.Lcho_2684 1.55e-27 116.0 COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,2VKIR@28216|Betaproteobacteria 28216|Betaproteobacteria E NAD-glutamate dehydrogenase gdhB - 1.4.1.2 ko:K15371 ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100 - R00243 RC00006,RC02799 ko00000,ko00001,ko01000 - - - Bac_GDH k59_845697_1 411684.HPDFL43_04306 6.23e-26 100.0 COG3909@1|root,COG3909@2|Bacteria,1N6Z5@1224|Proteobacteria,2UFS6@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Cytochrome C556 cycF - - - - - - - - - - - Cytochrom_C_2 k59_845697_2 1231190.NA8A_19685 7.51e-10 60.1 COG2010@1|root,COG2010@2|Bacteria,1MV6D@1224|Proteobacteria,2TT9U@28211|Alphaproteobacteria,43IDK@69277|Phyllobacteriaceae 28211|Alphaproteobacteria C Cytochrome c cycG GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - Cytochrom_C k59_979273_1 1266925.JHVX01000010_gene1322 3.67e-98 300.0 COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,2VHWM@28216|Betaproteobacteria,372BM@32003|Nitrosomonadales 28216|Betaproteobacteria P PFAM binding-protein-dependent transport systems inner membrane component oppC - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_553167_2 1005048.CFU_3721 1.29e-66 220.0 COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,2VIW1@28216|Betaproteobacteria,472BC@75682|Oxalobacteraceae 28216|Betaproteobacteria O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL - - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_593573_1 1173024.KI912149_gene5559 2.78e-15 75.1 COG1670@1|root,COG1670@2|Bacteria,1G6BV@1117|Cyanobacteria,1JM95@1189|Stigonemataceae 1117|Cyanobacteria J Acetyltransferase (GNAT) domain - - 2.3.1.128 ko:K03790 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_3 k59_593573_2 1122135.KB893146_gene1616 1.09e-33 123.0 COG1076@1|root,COG1076@2|Bacteria,1N270@1224|Proteobacteria,2TTX1@28211|Alphaproteobacteria 28211|Alphaproteobacteria O COG1076 DnaJ-domain-containing proteins 1 djlA - - ko:K05801 - - - - ko00000,ko03110 - - - DnaJ,TerB k59_937077_1 1306406.ASHX01000002_gene5452 2.64e-09 63.2 COG1361@1|root,COG3291@1|root,COG1361@2|Bacteria,COG3291@2|Bacteria 2|Bacteria S metallopeptidase activity - - - - - - - - - - - - Big_3_2,CHU_C,DUF11,DUF5011,Gram_pos_anchor k59_1278026_1 1267005.KB911261_gene2255 1.13e-94 280.0 COG0221@1|root,COG0221@2|Bacteria,1RA2F@1224|Proteobacteria,2TQZM@28211|Alphaproteobacteria,3N6U1@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria C Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions ppa - 3.6.1.1 ko:K01507 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyrophosphatase k59_1278026_2 1123060.JONP01000009_gene2080 9.47e-30 110.0 COG1546@1|root,COG1546@2|Bacteria,1RHXH@1224|Proteobacteria,2UACN@28211|Alphaproteobacteria,2JWT0@204441|Rhodospirillales 204441|Rhodospirillales S Competence-damaged protein - - - - - - - - - - - - CinA k59_1320459_1 713586.KB900536_gene937 1.08e-46 166.0 COG4191@1|root,COG4191@2|Bacteria,1QVHZ@1224|Proteobacteria,1S2DC@1236|Gammaproteobacteria,1WZY5@135613|Chromatiales 135613|Chromatiales T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - - - - - - - - - - HATPase_c,HisKA k59_593604_1 1532558.JL39_16615 9.64e-74 238.0 COG0654@1|root,COG0654@2|Bacteria,1N6PD@1224|Proteobacteria,2U19F@28211|Alphaproteobacteria,4BDU8@82115|Rhizobiaceae 28211|Alphaproteobacteria CH Alanine dehydrogenase/PNT, C-terminal domain - - - - - - - - - - - - FAD_oxidored k59_255273_1 1121035.AUCH01000008_gene1072 1.09e-77 243.0 COG2391@1|root,COG2391@2|Bacteria,1MXSE@1224|Proteobacteria,2VKGG@28216|Betaproteobacteria,2KVG7@206389|Rhodocyclales 206389|Rhodocyclales S Sulphur transport - - - ko:K07112 - - - - ko00000 - - - Sulf_transp k59_468178_1 713586.KB900536_gene1493 4.08e-59 194.0 COG2010@1|root,COG2010@2|Bacteria,1MUCW@1224|Proteobacteria,1RPYJ@1236|Gammaproteobacteria,1WWRW@135613|Chromatiales 135613|Chromatiales C C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex - - - ko:K00406 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - Cytochrome_CBB3,FixP_N k59_468237_1 765420.OSCT_0041 8.2e-59 194.0 COG1131@1|root,COG1131@2|Bacteria,2G7U7@200795|Chloroflexi,37725@32061|Chloroflexia 32061|Chloroflexia V PFAM ABC transporter related - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_468248_1 1123487.KB892835_gene3757 7.69e-37 136.0 COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,2VI2V@28216|Betaproteobacteria,2KVHH@206389|Rhodocyclales 206389|Rhodocyclales E Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia trpE - 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind k59_468248_2 287.DR97_3602 2.64e-82 249.0 COG0512@1|root,COG0512@2|Bacteria,1MV5Y@1224|Proteobacteria,1RMQW@1236|Gammaproteobacteria,1YEPV@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria EH Peptidase C26 pabA GO:0000162,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006575,GO:0006576,GO:0006586,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009108,GO:0009308,GO:0009309,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042398,GO:0042401,GO:0042430,GO:0042435,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046820,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 2.6.1.85,4.1.3.27 ko:K01658,ko:K01664 ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986,R01716 RC00010,RC01418,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_3095,iEC042_1314.EC042_3623,iECABU_c1320.ECABU_c37840,iECED1_1282.ECED1_4024,iECNA114_1301.ECNA114_3463,iECOK1_1307.ECOK1_3780,iECP_1309.ECP_3451,iECS88_1305.ECS88_3751,iECSF_1327.ECSF_3187,iLF82_1304.LF82_1586,iNRG857_1313.NRG857_16660,iUMN146_1321.UM146_16880,iUTI89_1310.UTI89_C3863,ic_1306.c4135 GATase k59_426170_1 378806.STAUR_6282 8.25e-166 475.0 COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,42M83@68525|delta/epsilon subdivisions,2WIZE@28221|Deltaproteobacteria,2YU8Q@29|Myxococcales 28221|Deltaproteobacteria H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine ahcY GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657 3.3.1.1 ko:K01251 ko00270,ko01100,map00270,map01100 M00035 R00192,R04936 RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko04147 - - - AdoHcyase,AdoHcyase_NAD k59_1278180_2 765913.ThidrDRAFT_0285 1.92e-58 188.0 COG1871@1|root,COG1871@2|Bacteria,1RDDB@1224|Proteobacteria,1S41X@1236|Gammaproteobacteria,1WVY2@135613|Chromatiales 135613|Chromatiales NT Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis cheD - 3.5.1.44 ko:K03411 ko02030,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheD k59_1278219_1 1379698.RBG1_1C00001G1527 5e-18 90.9 COG1404@1|root,COG1404@2|Bacteria,2NPDC@2323|unclassified Bacteria 2|Bacteria O Peptidase S8 - - 3.4.21.66 ko:K08651 - - - - ko00000,ko01000,ko01002,ko03110 - - - Peptidase_S8,fn3 k59_889177_1 380703.AHA_3251 4.8e-46 157.0 COG1057@1|root,COG1057@2|Bacteria,1RD0J@1224|Proteobacteria,1RP00@1236|Gammaproteobacteria,1Y4MD@135624|Aeromonadales 135624|Aeromonadales H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) nadD - 2.7.7.18 ko:K00969 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_1278275_1 358220.C380_03360 7.75e-95 298.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2VH0Y@28216|Betaproteobacteria,4AAB0@80864|Comamonadaceae 28216|Betaproteobacteria I 3-hydroxyacyl-CoA dehydrogenase fadB2 - 1.1.1.35,4.2.1.17,5.1.2.3 ko:K01782 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_1021944_1 883080.HMPREF9697_01740 5.88e-70 229.0 COG0277@1|root,COG0277@2|Bacteria,1MXTV@1224|Proteobacteria,2U0T4@28211|Alphaproteobacteria,3JRE4@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C PFAM FAD linked oxidase domain protein - - 2.5.1.26 ko:K00803 ko00565,ko01100,ko04146,map00565,map01100,map04146 - R04311 RC00020,RC02886 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_1235819_1 76114.ebA2945 1.21e-27 105.0 COG0746@1|root,COG0746@2|Bacteria,1RH3M@1224|Proteobacteria,2VQR2@28216|Betaproteobacteria,2KW8P@206389|Rhodocyclales 206389|Rhodocyclales H Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor mobA - 2.7.7.77 ko:K03752 ko00790,ko01100,map00790,map01100 - R11581 - ko00000,ko00001,ko01000 - - - NTP_transf_3 k59_469501_1 1370125.AUWT01000098_gene3799 1.72e-17 83.6 COG1484@1|root,COG1484@2|Bacteria,2H714@201174|Actinobacteria,236ZS@1762|Mycobacteriaceae 201174|Actinobacteria L IstB-like ATP binding protein - - - - - - - - - - - - IstB_IS21 k59_512168_1 246197.MXAN_3636 1.41e-51 186.0 COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,42NH4@68525|delta/epsilon subdivisions,2WN7A@28221|Deltaproteobacteria 28221|Deltaproteobacteria Q non-ribosomal peptide synthetase - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase k59_1194188_1 1207063.P24_00485 2.08e-90 289.0 COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2TQY9@28211|Alphaproteobacteria,2JRIJ@204441|Rhodospirillales 204441|Rhodospirillales S Tripartite ATP-independent periplasmic transporter, DctM component - - - - - - - - - - - - DctM k59_128588_1 420324.KI911965_gene734 1.02e-18 82.8 COG0778@1|root,COG0778@2|Bacteria,1MY39@1224|Proteobacteria,2TTZC@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG0778 Nitroreductase - - - - - - - - - - - - Nitroreductase k59_128588_2 395964.KE386496_gene2517 4.08e-52 170.0 COG2983@1|root,COG2983@2|Bacteria,1RHMX@1224|Proteobacteria,2U99S@28211|Alphaproteobacteria,3NAZX@45404|Beijerinckiaceae 28211|Alphaproteobacteria S Putative zinc- or iron-chelating domain MA20_15575 - - ko:K09160 - - - - ko00000 - - - CxxCxxCC k59_128590_1 290397.Adeh_1659 2.48e-91 282.0 COG3005@1|root,COG3005@2|Bacteria,1R956@1224|Proteobacteria,42Q0X@68525|delta/epsilon subdivisions,2WMHI@28221|Deltaproteobacteria 28221|Deltaproteobacteria C NapC/NirT cytochrome c family, N-terminal region - GO:0003674,GO:0003824,GO:0005575,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0031224,GO:0044237,GO:0044425,GO:0045333,GO:0055114 - - - - - - - - - - Cytochrom_NNT k59_853165_1 977880.RALTA_A2728 2.77e-125 370.0 COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,2VIKZ@28216|Betaproteobacteria,1K0U8@119060|Burkholderiaceae 28216|Betaproteobacteria M Belongs to the MurCDEF family murC - 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_1066525_1 28229.ND2E_3767 1.43e-09 60.1 COG0334@1|root,COG0334@2|Bacteria,1MUXS@1224|Proteobacteria,1RQ0T@1236|Gammaproteobacteria,2Q5TB@267889|Colwelliaceae 1236|Gammaproteobacteria E Belongs to the Glu Leu Phe Val dehydrogenases family ldh - 1.4.1.9 ko:K00263 ko00280,ko00290,ko01100,ko01110,ko01130,map00280,map00290,map01100,map01110,map01130 - R01088,R01434,R02196 RC00006,RC00036 ko00000,ko00001,ko01000 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_1066525_2 287.DR97_6303 7.8e-19 85.9 COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,1RREX@1236|Gammaproteobacteria,1YFH7@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria C Dehydrogenase E1 component bkdA1 - 1.2.4.4 ko:K00166 ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130 M00036 R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00027,RC00627,RC02743,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh,OxoDH_E1alpha_N k59_128614_1 1208323.B30_08333 1.36e-18 90.1 COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - - - - - - - - - - - CHASE,HAMP,HATPase_c,HisKA,MASE1,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,dCache_3,sCache_3_3 k59_938482_2 397945.Aave_1387 2.07e-54 172.0 COG0545@1|root,COG0545@2|Bacteria,1RDA1@1224|Proteobacteria,2VSIG@28216|Betaproteobacteria,4AEH2@80864|Comamonadaceae 28216|Betaproteobacteria G Peptidyl-prolyl cis-trans isomerase fkpA - 5.2.1.8 ko:K01802,ko:K03772 - - - - ko00000,ko01000,ko03110 - - - FKBP_C k59_938482_3 296591.Bpro_3399 5.77e-98 305.0 COG2918@1|root,COG2918@2|Bacteria,1MW9B@1224|Proteobacteria,2VKVU@28216|Betaproteobacteria,4AA8S@80864|Comamonadaceae 28216|Betaproteobacteria H Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily gshA - 6.3.2.2 ko:K01919 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00894,R10993 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - Glu_cys_ligase k59_554868_2 227882.SAV_1617 1.32e-11 63.9 COG0684@1|root,COG0684@2|Bacteria,2I8VQ@201174|Actinobacteria 201174|Actinobacteria H Methyltransferase - - 4.1.3.17 ko:K10218 ko00362,ko00660,ko01120,map00362,map00660,map01120 - R00008,R00350 RC00067,RC00502,RC01205 ko00000,ko00001,ko01000 - - - RraA-like k59_213833_1 1007105.PT7_2187 1.41e-88 270.0 COG1638@1|root,COG1638@2|Bacteria,1P3MK@1224|Proteobacteria 1224|Proteobacteria G COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component - - - ko:K11688 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.56.1 - - DctP k59_1154011_2 1038859.AXAU01000013_gene6552 1.74e-46 158.0 COG0111@1|root,COG0111@2|Bacteria,1MW0R@1224|Proteobacteria,2TWC9@28211|Alphaproteobacteria,3JVP3@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria EH D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain - - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C k59_770630_1 640081.Dsui_0407 7.17e-59 190.0 COG2518@1|root,COG2518@2|Bacteria,1RD6S@1224|Proteobacteria,2VJX3@28216|Betaproteobacteria,2KUMH@206389|Rhodocyclales 206389|Rhodocyclales O protein-L-isoaspartate(D-aspartate) O-methyltransferase - - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT k59_514652_1 977880.RALTA_A0218 2.39e-63 216.0 COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,2VH05@28216|Betaproteobacteria,1K4Q5@119060|Burkholderiaceae 28216|Betaproteobacteria EI Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly icmF GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0006139,GO:0006163,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016866,GO:0017076,GO:0017111,GO:0019001,GO:0019637,GO:0019693,GO:0019842,GO:0031419,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0034784,GO:0035383,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043603,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046872,GO:0046906,GO:0047727,GO:0048037,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564 5.4.99.13 ko:K11942 - - - - ko00000,ko01000 - - - ArgK,B12-binding,MM_CoA_mutase k59_1069574_1 1500306.JQLA01000003_gene4700 3.31e-59 199.0 COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,2TVJE@28211|Alphaproteobacteria,4B7YS@82115|Rhizobiaceae 28211|Alphaproteobacteria I Biotin carboxylase, N-terminal domain accC3 - 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_46123_1 649638.Trad_1144 2.42e-20 90.1 COG1309@1|root,COG1309@2|Bacteria,1WI7P@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_C_4,TetR_C_5,TetR_N k59_88190_1 1142394.PSMK_08050 1.47e-104 319.0 COG3046@1|root,COG3046@2|Bacteria,2IY44@203682|Planctomycetes 203682|Planctomycetes S protein related to deoxyribodipyrimidine photolyase - - - ko:K06876 - - - - ko00000 - - - DPRP,FAD_binding_7 k59_1027059_1 570967.JMLV01000012_gene3152 7.99e-95 288.0 COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,2TQYV@28211|Alphaproteobacteria,2JPU4@204441|Rhodospirillales 204441|Rhodospirillales IQ Beta-ketoacyl synthase, C-terminal domain - - 2.3.1.41 ko:K00647 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_685178_1 640081.Dsui_0385 1.07e-35 128.0 COG1418@1|root,COG1418@2|Bacteria,1RH6M@1224|Proteobacteria,2VRKW@28216|Betaproteobacteria,2KZQG@206389|Rhodocyclales 206389|Rhodocyclales S mRNA catabolic process - - - - - - - - - - - - - k59_685178_2 1265502.KB905941_gene2913 4.92e-150 434.0 COG0773@1|root,COG0773@2|Bacteria,1MUC5@1224|Proteobacteria,2VIX5@28216|Betaproteobacteria,4A9UY@80864|Comamonadaceae 28216|Betaproteobacteria M Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate mpl - 6.3.2.45 ko:K02558 - - - - ko00000,ko01000 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_344421_1 666685.R2APBS1_3673 2.03e-19 90.1 29TFP@1|root,30ENV@2|Bacteria,1RG86@1224|Proteobacteria,1SGXK@1236|Gammaproteobacteria,1X6ZE@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - - k59_344437_1 83219.PM02_19155 1.8e-36 132.0 COG3547@1|root,COG3547@2|Bacteria,1MXKJ@1224|Proteobacteria,2U2G6@28211|Alphaproteobacteria,3ZZ8R@60136|Sulfitobacter 28211|Alphaproteobacteria L Transposase IS116/IS110/IS902 family - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_302396_1 504832.OCAR_7524 2.64e-114 338.0 COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TRS8@28211|Alphaproteobacteria,3JS1M@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria EP Binding-protein-dependent transport system inner membrane component nikB - - ko:K02033,ko:K15585 ko02010,ko02024,map02010,map02024 M00239,M00440 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_855371_1 1121381.JNIV01000041_gene1122 6.66e-18 86.7 COG2084@1|root,COG2084@2|Bacteria 2|Bacteria I phosphogluconate dehydrogenase (decarboxylating) activity glxR - 1.1.1.60 ko:K00042 ko00630,ko01100,map00630,map01100 - R01745,R01747 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_386460_1 627192.SLG_37750 2.8e-25 106.0 COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,2TR7V@28211|Alphaproteobacteria,2K0I6@204457|Sphingomonadales 204457|Sphingomonadales L helicase lhr - - ko:K03724 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_assoc,Helicase_C k59_642505_1 935840.JAEQ01000001_gene3087 2.02e-16 79.0 COG0365@1|root,COG0365@2|Bacteria,1MUX7@1224|Proteobacteria,2TRND@28211|Alphaproteobacteria,43IUF@69277|Phyllobacteriaceae 28211|Alphaproteobacteria I COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases acsA1 - 6.2.1.16 ko:K01907 ko00280,ko00650,map00280,map00650 - R01357 RC00004,RC00014 ko00000,ko00001,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_642505_2 316067.Geob_1205 5.31e-13 69.3 COG0824@1|root,COG0824@2|Bacteria,1PF7Z@1224|Proteobacteria,42SV4@68525|delta/epsilon subdivisions,2WPY3@28221|Deltaproteobacteria,43SSY@69541|Desulfuromonadales 28221|Deltaproteobacteria S Thioesterase-like superfamily - - - ko:K07107 - - - - ko00000,ko01000 - - - 4HBT_2 k59_642505_3 634177.GLX_18020 1.37e-22 95.9 COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,2TS0R@28211|Alphaproteobacteria,2JPVD@204441|Rhodospirillales 204441|Rhodospirillales C Electron transfer flavoprotein-ubiquinone oxidoreductase - - 1.5.5.1 ko:K00311 - - - - ko00000,ko01000 - - - ETF_QO,FAD_binding_2,NAD_binding_8 k59_4119_1 1121861.KB899912_gene1019 2.03e-52 176.0 COG0473@1|root,COG0473@2|Bacteria,1QU2H@1224|Proteobacteria,2VFXG@28211|Alphaproteobacteria,2JRH8@204441|Rhodospirillales 204441|Rhodospirillales CE Isocitrate/isopropylmalate dehydrogenase - - 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_4119_2 113395.AXAI01000002_gene5469 1.08e-39 141.0 COG1319@1|root,COG1319@2|Bacteria,1MUDB@1224|Proteobacteria,2TTJF@28211|Alphaproteobacteria,3JT56@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C CO dehydrogenase flavoprotein C-terminal domain - - 1.2.5.3 ko:K03519 - - R11168 RC02800 ko00000,ko01000 - - - CO_deh_flav_C,FAD_binding_5 k59_130821_1 1509405.GV67_14030 4.49e-58 195.0 COG3666@1|root,COG3666@2|Bacteria,1QW5T@1224|Proteobacteria,2TWNW@28211|Alphaproteobacteria,4BP2N@82115|Rhizobiaceae 28211|Alphaproteobacteria L Transposase DDE domain tnp* - - - - - - - - - - - DDE_Tnp_1_6,DUF772 k59_1196733_1 76114.ebA6817 1.64e-57 187.0 COG0709@1|root,COG0709@2|Bacteria,1MWFG@1224|Proteobacteria,2VJSD@28216|Betaproteobacteria,2KUV8@206389|Rhodocyclales 206389|Rhodocyclales F Synthesizes selenophosphate from selenide and ATP selD - 2.7.9.3 ko:K01008 ko00450,ko01100,map00450,map01100 - R03595 RC00002,RC02878 ko00000,ko00001,ko01000,ko03016 - - - AIRS,AIRS_C k59_1196733_2 981384.AEYW01000006_gene2779 8.81e-11 67.8 COG0500@1|root,COG2226@2|Bacteria,1PPKI@1224|Proteobacteria,2TRIB@28211|Alphaproteobacteria,4NBF0@97050|Ruegeria 28211|Alphaproteobacteria Q Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - - - - - - - - - - Methyltransf_25,Methyltransf_31 k59_642532_1 1304883.KI912532_gene3146 9.71e-28 113.0 COG0144@1|root,COG0144@2|Bacteria,1MV2Q@1224|Proteobacteria,2VI1D@28216|Betaproteobacteria,2KUND@206389|Rhodocyclales 206389|Rhodocyclales J Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family - - 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F,Methyltr_RsmF_N k59_642532_3 864073.HFRIS_012594 8.24e-31 114.0 COG0299@1|root,COG0299@2|Bacteria,1MWN1@1224|Proteobacteria,2VJG8@28216|Betaproteobacteria,473PS@75682|Oxalobacteraceae 28216|Betaproteobacteria F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate purN - 2.1.2.2 ko:K11175 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04325,R04326 RC00026,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 - - - Formyl_trans_N k59_1324906_1 1122604.JONR01000014_gene215 4.43e-12 65.9 COG2808@1|root,COG2808@2|Bacteria,1N1B9@1224|Proteobacteria,1S7MT@1236|Gammaproteobacteria,1X6HS@135614|Xanthomonadales 135614|Xanthomonadales K transcriptional regulator paiB - - ko:K07734 - - - - ko00000,ko03000 - - - FMN_bind_2 k59_1324906_2 497321.C664_00865 5.57e-24 97.8 COG1514@1|root,COG1514@2|Bacteria,1RDB2@1224|Proteobacteria,2VTZU@28216|Betaproteobacteria,2KWXS@206389|Rhodocyclales 206389|Rhodocyclales J Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester ligT - 3.1.4.58 ko:K01975 - - - - ko00000,ko01000,ko03016 - - - LigT_PEase k59_1239429_1 1125863.JAFN01000001_gene2834 3.36e-48 166.0 COG0674@1|root,COG0674@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2WJG3@28221|Deltaproteobacteria 28221|Deltaproteobacteria C PFAM Pyruvate flavodoxin ferredoxin oxidoreductase - - 1.2.7.1 ko:K00169 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR_N k59_1239429_2 644282.Deba_3203 1e-06 47.8 COG1144@1|root,COG1144@2|Bacteria,1N99V@1224|Proteobacteria,42V8C@68525|delta/epsilon subdivisions,2WRCP@28221|Deltaproteobacteria 28221|Deltaproteobacteria C pyruvate ferredoxin flavodoxin oxidoreductase, delta subunit - - 1.2.7.1 ko:K00171 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - Fer4 k59_685291_1 273677.BW34_00896 2.82e-08 55.5 COG1088@1|root,COG1088@2|Bacteria,2GNDU@201174|Actinobacteria,4FKJH@85023|Microbacteriaceae 201174|Actinobacteria M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily rfbB - 4.2.1.46 ko:K01710 ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130 M00793 R06513 RC00402 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd k59_685309_1 317619.ANKN01000192_gene529 2.25e-51 188.0 COG1305@1|root,COG1305@2|Bacteria,1GJ51@1117|Cyanobacteria,1MPA8@1212|Prochloraceae 1117|Cyanobacteria E Transglutaminase/protease-like homologues - - - - - - - - - - - - Transglut_core k59_983700_1 396014.BF93_07905 6.81e-57 186.0 COG0745@1|root,COG0745@2|Bacteria,2H3IN@201174|Actinobacteria,4FCH7@85020|Dermabacteraceae 201174|Actinobacteria KT Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Response_reg,Trans_reg_C k59_1027244_1 663932.KB902575_gene937 2.46e-42 159.0 COG2010@1|root,COG4993@1|root,COG2010@2|Bacteria,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TS2Q@28211|Alphaproteobacteria,2JR1Q@204441|Rhodospirillales 204441|Rhodospirillales G PQQ-like domain adhA - 1.1.5.5 ko:K22473 ko00010,map00010 - R09479 RC00088 ko00000,ko00001,ko01000 - - - Cytochrome_CBB3,PQQ,PQQ_2 k59_855473_1 1218075.BAYA01000005_gene1887 1.36e-138 404.0 COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,2VM53@28216|Betaproteobacteria,1K0IU@119060|Burkholderiaceae 28216|Betaproteobacteria C maleylacetate reductase macA - 1.3.1.32 ko:K00217 ko00361,ko00362,ko00364,ko00623,ko01100,ko01120,ko01220,map00361,map00362,map00364,map00623,map01100,map01120,map01220 - R02988,R02989,R05355,R06848,R07781,R09137,R09138,R09223,R09224 RC00107,RC01335,RC01689,RC02442 ko00000,ko00001,ko01000 - - - Fe-ADH k59_855473_2 1437824.BN940_14586 3.79e-16 79.3 COG0477@1|root,COG2814@2|Bacteria,1PE5A@1224|Proteobacteria,2VHTJ@28216|Betaproteobacteria,3T1CE@506|Alcaligenaceae 28216|Betaproteobacteria EGP Permeases of the major facilitator superfamily emrB_1 - - - - - - - - - - - MFS_1,Sugar_tr k59_557216_1 640081.Dsui_2415 5.56e-24 102.0 COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,2VHHQ@28216|Betaproteobacteria,2KU7T@206389|Rhodocyclales 206389|Rhodocyclales Q ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX k59_557216_2 1218075.BAYA01000001_gene43 4.89e-41 142.0 COG4181@1|root,COG4181@2|Bacteria,1MXG9@1224|Proteobacteria,2VI54@28216|Betaproteobacteria,1K425@119060|Burkholderiaceae 28216|Betaproteobacteria Q ABC transporter lolD - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1154235_1 1157708.KB907450_gene5828 1.49e-91 276.0 COG0668@1|root,COG0668@2|Bacteria,1N2GE@1224|Proteobacteria,2WFQP@28216|Betaproteobacteria,4ABHJ@80864|Comamonadaceae 28216|Betaproteobacteria M PFAM Conserved TM helix repeat-containing protein - - - - - - - - - - - - TM_helix k59_1154235_2 314278.NB231_16468 6.16e-29 115.0 COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,1RP6F@1236|Gammaproteobacteria,1WX62@135613|Chromatiales 135613|Chromatiales G Belongs to the glycosyl hydrolase 13 family - - 3.2.1.68 ko:K01214 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11261 - ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48 k59_514860_1 519989.ECTPHS_00120 6.65e-73 226.0 COG1469@1|root,COG1469@2|Bacteria,1MV1B@1224|Proteobacteria,1RNDY@1236|Gammaproteobacteria,1WW3H@135613|Chromatiales 135613|Chromatiales S Converts GTP to 7,8-dihydroneopterin triphosphate folE2 - 3.5.4.16 ko:K09007 ko00790,ko01100,map00790,map01100 M00126 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - GCHY-1 k59_46356_2 1218074.BAXZ01000015_gene3202 3.14e-22 96.3 COG0457@1|root,COG3118@1|root,COG0457@2|Bacteria,COG3118@2|Bacteria,1MYB8@1224|Proteobacteria,2VI6C@28216|Betaproteobacteria,1K1RH@119060|Burkholderiaceae 28216|Betaproteobacteria O TPR repeat-containing protein - - - - - - - - - - - - TPR_16,TPR_19,TPR_8 k59_173919_1 566466.NOR53_465 8.98e-44 159.0 COG3746@1|root,COG3746@2|Bacteria 2|Bacteria - - - - - ko:K07221 - - - - ko00000,ko02000 1.B.5.1 - - Porin_O_P k59_130946_1 287986.DV20_42275 9.28e-10 61.2 COG1595@1|root,COG1595@2|Bacteria,2GMRK@201174|Actinobacteria,4DXVD@85010|Pseudonocardiales 201174|Actinobacteria K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2,SnoaL_2 k59_46391_1 864073.HFRIS_024252 4.92e-82 260.0 COG0155@1|root,COG0155@2|Bacteria,1MVVB@1224|Proteobacteria,2VIYX@28216|Betaproteobacteria,473ZZ@75682|Oxalobacteraceae 28216|Betaproteobacteria C Sulfite reductase, beta subunit (Hemoprotein) cysI - 1.8.1.2,1.8.7.1 ko:K00381,ko:K00392 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R00858,R00859,R03600 RC00065 ko00000,ko00001,ko00002,ko01000 - - - NIR_SIR,NIR_SIR_ferr k59_1196890_1 76114.ebA4823 1.56e-106 325.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2VHEV@28216|Betaproteobacteria,2KU76@206389|Rhodocyclales 206389|Rhodocyclales O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_728025_1 1121351.AUAP01000021_gene1255 4.82e-82 253.0 COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,2VH2M@28216|Betaproteobacteria,2KPF2@206351|Neisseriales 206351|Neisseriales C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate leuB - 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_728025_2 1219031.BBJR01000001_gene510 4.37e-07 50.1 COG0066@1|root,COG0066@2|Bacteria,1MVXB@1224|Proteobacteria,2VIJC@28216|Betaproteobacteria,4AA66@80864|Comamonadaceae 28216|Betaproteobacteria E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuD - 4.2.1.33,4.2.1.35 ko:K01704 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R10170 RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase_C k59_1282014_1 283166.BH16290 3.52e-23 97.8 COG0204@1|root,COG0204@2|Bacteria,1MY51@1224|Proteobacteria,2TT3P@28211|Alphaproteobacteria,48TC0@772|Bartonellaceae 28211|Alphaproteobacteria I Phosphate acyltransferases plsC - 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_1282014_2 1123366.TH3_18919 1.42e-07 52.4 COG1434@1|root,COG1434@2|Bacteria,1RHMV@1224|Proteobacteria,2U957@28211|Alphaproteobacteria,2JSAU@204441|Rhodospirillales 204441|Rhodospirillales S DUF218 domain - - - - - - - - - - - - DUF218 k59_130975_1 395494.Galf_2047 1.62e-68 241.0 COG3164@1|root,COG3164@2|Bacteria,1MXWF@1224|Proteobacteria,2VH52@28216|Betaproteobacteria,44VDF@713636|Nitrosomonadales 28216|Betaproteobacteria S Protein of unknown function - - - - - - - - - - - - AsmA_2,DUF3971 k59_1027380_1 1122139.KB907879_gene2905 1.22e-68 224.0 COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,1RMN6@1236|Gammaproteobacteria,1XJ03@135619|Oceanospirillales 135619|Oceanospirillales P Trk system potassium uptake protein - - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_1111303_1 1110502.TMO_2476 1.11e-15 73.6 COG1320@1|root,COG1320@2|Bacteria,1N75I@1224|Proteobacteria,2UETR@28211|Alphaproteobacteria 28211|Alphaproteobacteria P monovalent cation proton antiporter, MnhG PhaG subunit - - - ko:K05571 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - PhaG_MnhG_YufB k59_1111303_2 998674.ATTE01000001_gene739 2.91e-29 107.0 COG2212@1|root,COG2212@2|Bacteria,1N6VV@1224|Proteobacteria,1SE40@1236|Gammaproteobacteria,462U9@72273|Thiotrichales 72273|Thiotrichales P Multiple resistance and pH regulation protein F (MrpF / PhaF) - - - ko:K05570 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - MrpF_PhaF k59_859033_1 1218084.BBJK01000037_gene3499 8.42e-15 76.6 COG2084@1|root,COG2084@2|Bacteria,1MWR4@1224|Proteobacteria,2W0FJ@28216|Betaproteobacteria,1KFFZ@119060|Burkholderiaceae 28216|Betaproteobacteria I NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - 1.1.1.31 ko:K00020 ko00280,ko01100,map00280,map01100 - R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_859033_2 391615.ABSJ01000005_gene548 2.99e-10 61.6 COG0318@1|root,COG0318@2|Bacteria,1MUMC@1224|Proteobacteria,1RMGS@1236|Gammaproteobacteria 1236|Gammaproteobacteria IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II alkK - 6.2.1.44 ko:K20034 ko00920,map00920 - R10820 RC00004,RC00014 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C k59_1329953_2 400668.Mmwyl1_3481 3.86e-23 100.0 COG0438@1|root,COG0438@2|Bacteria,1R7VT@1224|Proteobacteria,1SYK1@1236|Gammaproteobacteria,1XK90@135619|Oceanospirillales 135619|Oceanospirillales M Glycosyl transferases group 1 - - - - - - - - - - - - Glycos_transf_1 k59_1329979_1 871963.Desdi_3158 0.000785 41.2 COG0686@1|root,COG0686@2|Bacteria,1TNZ5@1239|Firmicutes,2489D@186801|Clostridia,260WZ@186807|Peptococcaceae 186801|Clostridia C Belongs to the AlaDH PNT family ald - 1.4.1.1 ko:K00259 ko00250,ko00430,ko01100,map00250,map00430,map01100 - R00396 RC00008 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N k59_1329979_2 1123229.AUBC01000008_gene370 1.38e-19 88.2 COG0604@1|root,COG0604@2|Bacteria,1MWRK@1224|Proteobacteria,2TQMF@28211|Alphaproteobacteria,3JRI0@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Zinc-binding dehydrogenase MA20_25320 - 1.1.1.1,1.6.5.5 ko:K00001,ko:K00344 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_307651_1 309807.SRU_0853 7.15e-69 222.0 COG3039@1|root,COG3039@2|Bacteria,4PM5N@976|Bacteroidetes 2|Bacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_3 k59_1114736_1 1121875.KB907553_gene20 1.86e-11 64.3 COG5361@1|root,COG5361@2|Bacteria,4NKSK@976|Bacteroidetes,1IARY@117743|Flavobacteriia 976|Bacteroidetes S Protein of unknown function (DUF1254) - - - - - - - - - - - - DUF1214,DUF1254 k59_816349_1 76114.ebA1312 4.77e-49 163.0 COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,2VI5T@28216|Betaproteobacteria,2KUIX@206389|Rhodocyclales 206389|Rhodocyclales Q COG0767 ABC-type transport system involved in resistance to organic solvents, permease component - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE k59_816349_2 1101195.Meth11DRAFT_0324 1.18e-26 102.0 COG1463@1|root,COG1463@2|Bacteria,1NCUG@1224|Proteobacteria,2VRKR@28216|Betaproteobacteria,2KMJU@206350|Nitrosomonadales 206350|Nitrosomonadales Q PFAM Mammalian cell entry related domain protein - - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD k59_1158363_1 580332.Slit_2681 1.07e-42 159.0 COG1629@1|root,COG4771@2|Bacteria,1RA71@1224|Proteobacteria,2WGMC@28216|Betaproteobacteria,44V6B@713636|Nitrosomonadales 28216|Betaproteobacteria P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1200984_1 1437824.BN940_09831 8.57e-245 699.0 COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,2VIAH@28216|Betaproteobacteria,3T2IP@506|Alcaligenaceae 28216|Betaproteobacteria C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) aceE GO:0000287,GO:0003674,GO:0003824,GO:0004738,GO:0005488,GO:0005515,GO:0008150,GO:0008152,GO:0016491,GO:0016903,GO:0019842,GO:0030976,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0046872,GO:0046983,GO:0048037,GO:0050662,GO:0055114,GO:0097159,GO:1901363,GO:1901681 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N k59_902587_1 1288494.EBAPG3_2600 2.87e-35 129.0 COG0762@1|root,COG0762@2|Bacteria,1RCZV@1224|Proteobacteria,2VRHV@28216|Betaproteobacteria,3730Z@32003|Nitrosomonadales 28216|Betaproteobacteria S YGGT family - - - ko:K02221 - - - - ko00000,ko02044 - - - YGGT k59_902587_2 1123279.ATUS01000001_gene2539 3.19e-17 76.3 COG1872@1|root,COG1872@2|Bacteria,1MZ4E@1224|Proteobacteria,1S9AB@1236|Gammaproteobacteria,1J6X7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the UPF0235 family yggU - - ko:K09131 - - - - ko00000 - - - DUF167 k59_902587_3 1121479.AUBS01000005_gene2664 9.81e-12 65.9 COG0111@1|root,COG0111@2|Bacteria,1MW1U@1224|Proteobacteria,2TSUU@28211|Alphaproteobacteria 28211|Alphaproteobacteria EH D-isomer specific 2-hydroxyacid dehydrogenase ghrA - 1.1.1.79,1.1.1.81 ko:K12972 ko00260,ko00620,ko00630,ko01100,ko01110,ko01120,map00260,map00620,map00630,map01100,map01110,map01120 - R00465,R01388,R01392,R02527 RC00031,RC00042,RC00670 ko00000,ko00001,ko01000 - - - 2-Hacid_dh_C k59_349619_1 987059.RBXJA2T_16942 4.1e-56 194.0 COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,2VINT@28216|Betaproteobacteria,1KJN8@119065|unclassified Burkholderiales 28216|Betaproteobacteria L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA - - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,ResIII k59_349640_1 395965.Msil_0415 1.8e-14 73.2 COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,2TS6F@28211|Alphaproteobacteria,3NA6X@45404|Beijerinckiaceae 28211|Alphaproteobacteria L DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA - - ko:K04485 - - - - ko00000,ko03400 - - - AAA_25,ATPase,ChlI k59_349640_2 1122137.AQXF01000002_gene91 1.95e-55 179.0 COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,2TR2I@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q ABC transporter mkl - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran k59_349662_1 404589.Anae109_1349 2.29e-66 213.0 COG3335@1|root,COG3335@2|Bacteria,1MW7X@1224|Proteobacteria,42Q11@68525|delta/epsilon subdivisions,2WKFK@28221|Deltaproteobacteria 28221|Deltaproteobacteria L DDE superfamily endonuclease - - - - - - - - - - - - DDE_3,HTH_32 k59_307755_1 261292.Nit79A3_0003 1.77e-91 290.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,2VI8N@28216|Betaproteobacteria,3725J@32003|Nitrosomonadales 28216|Betaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_1158413_1 930169.B5T_04160 1.04e-53 176.0 COG4221@1|root,COG4221@2|Bacteria,1MWXS@1224|Proteobacteria,1RQSN@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_1158413_2 639030.JHVA01000001_gene1740 6.18e-17 76.3 COG1246@1|root,COG1246@2|Bacteria,3Y9DA@57723|Acidobacteria,2JMUP@204432|Acidobacteriia 204432|Acidobacteriia E FR47-like protein - - - - - - - - - - - - Acetyltransf_1 k59_519104_1 506534.Rhein_3581 8.42e-45 159.0 COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1Q7PK@1224|Proteobacteria,1RSF0@1236|Gammaproteobacteria,1WWA3@135613|Chromatiales 135613|Chromatiales L PFAM Integrase core domain - - - - - - - - - - - - DDE_3,HTH_23,HTH_29,HTH_33 k59_902647_1 1282362.AEAC466_18625 8.75e-61 199.0 COG2850@1|root,COG2850@2|Bacteria,1MUAC@1224|Proteobacteria,2TSG2@28211|Alphaproteobacteria,2KHVD@204458|Caulobacterales 204458|Caulobacterales S transcription factor jumonji - - - - - - - - - - - - Cupin_8 k59_51547_1 1122619.KB892281_gene1826 2.78e-25 109.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2VHSK@28216|Betaproteobacteria,3T2BM@506|Alcaligenaceae 28216|Betaproteobacteria KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance relA - 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_1114825_1 1163617.SCD_n02935 4.22e-36 131.0 COG2863@1|root,COG2863@2|Bacteria,1N2NB@1224|Proteobacteria,2VQNZ@28216|Betaproteobacteria 28216|Betaproteobacteria C PFAM Cytochrome c, class I cyc - - - - - - - - - - - Cytochrom_C,Cytochrome_CBB3 k59_1114825_2 547045.NEISICOT_01330 1.23e-16 75.9 COG0756@1|root,COG0756@2|Bacteria,1RA7P@1224|Proteobacteria,2VQ5I@28216|Betaproteobacteria,2KR3P@206351|Neisseriales 206351|Neisseriales F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA dut - 3.6.1.23 ko:K01520 ko00240,ko00983,ko01100,map00240,map00983,map01100 M00053 R02100,R11896 RC00002 ko00000,ko00001,ko00002,ko01000,ko03400 - - - dUTPase k59_9354_1 946483.Cenrod_1942 7.55e-65 207.0 COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,2VI8C@28216|Betaproteobacteria,4AAPJ@80864|Comamonadaceae 28216|Betaproteobacteria F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate folD - 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 - - - THF_DHG_CYH,THF_DHG_CYH_C k59_816435_1 1100721.ALKO01000018_gene1164 7.06e-24 105.0 COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2VHB9@28216|Betaproteobacteria,4AAS9@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM aldehyde oxidase and xanthine dehydrogenase molybdopterin binding - - - - - - - - - - - - Ald_Xan_dh_C2 k59_1158440_1 1318628.MARLIPOL_13384 1.56e-97 297.0 COG1639@1|root,COG2606@1|root,COG1639@2|Bacteria,COG2606@2|Bacteria,1R46H@1224|Proteobacteria,1S1DF@1236|Gammaproteobacteria,46CHJ@72275|Alteromonadaceae 1236|Gammaproteobacteria T Signal transduction protein - - - - - - - - - - - - HDOD,tRNA_edit k59_902685_1 1123251.ATWM01000009_gene2876 9.94e-59 194.0 COG0549@1|root,COG0549@2|Bacteria,2HWQ6@201174|Actinobacteria,4FFY6@85021|Intrasporangiaceae 201174|Actinobacteria E Belongs to the carbamate kinase family arcC - 2.7.2.2 ko:K00926 ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200 - R00150,R01395 RC00002,RC00043,RC02803,RC02804 ko00000,ko00001,ko01000 - - - AA_kinase k59_1330163_1 1070319.CAGGBEG34_360009 4.41e-111 330.0 COG0418@1|root,COG0418@2|Bacteria,1MUYP@1224|Proteobacteria,2VH6F@28216|Betaproteobacteria,1K06B@119060|Burkholderiaceae 28216|Betaproteobacteria F Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate pyrC - 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 k59_1330163_2 1392838.AWNM01000063_gene4083 1.29e-13 71.2 COG0313@1|root,COG0313@2|Bacteria,1MU0E@1224|Proteobacteria,2VHI1@28216|Betaproteobacteria,3T32X@506|Alcaligenaceae 28216|Betaproteobacteria H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA rsmI - 2.1.1.198 ko:K07056 - - - - ko00000,ko01000,ko03009 - - - TP_methylase k59_859186_1 1382306.JNIM01000001_gene221 4.6e-53 180.0 COG0627@1|root,COG0627@2|Bacteria 2|Bacteria J Serine hydrolase involved in the detoxification of formaldehyde - - - - - - - - - - - - Esterase k59_859186_2 931627.MycrhDRAFT_4771 2.09e-40 138.0 COG0599@1|root,COG0599@2|Bacteria,2IM8G@201174|Actinobacteria,239Q5@1762|Mycobacteriaceae 201174|Actinobacteria S decarboxylase pcaC - 4.1.1.44 ko:K01607 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 - R03470 RC00938 ko00000,ko00001,ko01000 - - - CMD k59_894425_2 652103.Rpdx1_3839 4.55e-29 111.0 COG1028@1|root,COG1028@2|Bacteria,1MWJI@1224|Proteobacteria,2TRNJ@28211|Alphaproteobacteria,3JS4Z@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria IQ Enoyl-(Acyl carrier protein) reductase MA20_19195 - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_849940_1 319003.Bra1253DRAFT_04604 2.58e-56 188.0 COG4638@1|root,COG4638@2|Bacteria,1MX47@1224|Proteobacteria,2TV03@28211|Alphaproteobacteria,3JV2C@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P Rieske [2Fe-2S] domain MA20_22525 - - - - - - - - - - - Aromatic_hydrox,Rieske k59_849940_2 1298867.AUES01000005_gene210 3.48e-11 62.0 COG0410@1|root,COG0410@2|Bacteria,1MVYI@1224|Proteobacteria,2TSRT@28211|Alphaproteobacteria,3JR1U@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E ABC transporter MA20_22545 - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran k59_849950_1 1121106.JQKB01000014_gene5711 1.06e-84 269.0 COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,2TVYU@28211|Alphaproteobacteria,2JV59@204441|Rhodospirillales 28211|Alphaproteobacteria EQ Hydantoinase B/oxoprolinase - - - - - - - - - - - - Hydantoinase_B k59_894702_1 1163617.SCD_n02454 3.08e-30 111.0 COG1539@1|root,COG1539@2|Bacteria,1MZ8Z@1224|Proteobacteria,2VUVV@28216|Betaproteobacteria 28216|Betaproteobacteria H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin folB - 1.13.11.81,4.1.2.25,5.1.99.8 ko:K01633 ko00790,ko01100,map00790,map01100 M00126,M00840 R03504,R11037,R11073 RC00721,RC00943,RC01479,RC03333,RC03334 ko00000,ko00001,ko00002,ko01000 - - - FolB k59_894702_2 29581.BW37_00610 1.08e-68 216.0 COG0344@1|root,COG0344@2|Bacteria,1RD4Z@1224|Proteobacteria,2VQ10@28216|Betaproteobacteria,472B0@75682|Oxalobacteraceae 28216|Betaproteobacteria I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP plsY - 2.3.1.15 ko:K08591 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - G3P_acyltransf k59_894702_3 267608.RSc2219 1.21e-37 138.0 COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,2VHDR@28216|Betaproteobacteria,1K0V6@119060|Burkholderiaceae 28216|Betaproteobacteria J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction tsaD - 2.3.1.234 ko:K01409 - - R10648 RC00070,RC00416 ko00000,ko01000,ko03016 - - - Peptidase_M22 k59_850216_1 240015.ACP_2972 9.67e-40 146.0 COG0380@1|root,COG0380@2|Bacteria,3Y3X7@57723|Acidobacteria,2JKGZ@204432|Acidobacteriia 204432|Acidobacteriia G Glycosyltransferase family 20 - - 2.4.1.15,2.4.1.347 ko:K00697 ko00500,ko01100,map00500,map01100 - R02737 RC00005,RC00049,RC02748 ko00000,ko00001,ko01000,ko01003 - GT20 - Glyco_transf_20 k59_850244_1 1392838.AWNM01000054_gene2965 5.98e-51 176.0 COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,2VI67@28216|Betaproteobacteria,3T203@506|Alcaligenaceae 28216|Betaproteobacteria M transferase kdtA - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02527 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763 RC00009,RC00077,RC00247 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT30 - Glycos_transf_1,Glycos_transf_N k59_850401_1 1121035.AUCH01000007_gene560 2.3e-06 48.1 COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,2VIQ5@28216|Betaproteobacteria,2KUKK@206389|Rhodocyclales 206389|Rhodocyclales H Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate ilvC - 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 - - - IlvC,IlvN k59_850401_2 580332.Slit_2403 1.03e-79 240.0 COG0440@1|root,COG0440@2|Bacteria,1RAGN@1224|Proteobacteria,2VH1H@28216|Betaproteobacteria,44VPP@713636|Nitrosomonadales 28216|Betaproteobacteria E ACT domain ilvH GO:0003674,GO:0003824,GO:0003984,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005948,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234 2.2.1.6 ko:K01653 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - ACT_5,ALS_ss_C k59_850473_3 580332.Slit_2404 5.65e-19 85.9 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2VJ55@28216|Betaproteobacteria,44V6P@713636|Nitrosomonadales 28216|Betaproteobacteria H PFAM thiamine pyrophosphate ilvI - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_851081_1 85643.Tmz1t_2130 1.37e-63 205.0 COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,2VJ89@28216|Betaproteobacteria,2KVYN@206389|Rhodocyclales 206389|Rhodocyclales S tRNA-splicing ligase RtcB - - 6.5.1.3 ko:K14415 - - - - ko00000,ko01000,ko03016 - - - RtcB k59_851132_1 1110502.TMO_0216 1.19e-44 159.0 COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,2TQKD@28211|Alphaproteobacteria,2JPXT@204441|Rhodospirillales 204441|Rhodospirillales M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids alr - 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 - R00401 RC00285 ko00000,ko00001,ko01000,ko01011 - - - Ala_racemase_C,Ala_racemase_N k59_1149427_1 911045.PSE_0787 6.16e-29 109.0 COG0813@1|root,COG0813@2|Bacteria,1MUW6@1224|Proteobacteria,2TRQM@28211|Alphaproteobacteria 28211|Alphaproteobacteria F phosphorylase deoD - 2.4.2.1 ko:K03784 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244 RC00033,RC00063,RC00122 ko00000,ko00001,ko01000 - - - PNP_UDP_1 k59_1149491_1 765911.Thivi_3385 7.34e-31 119.0 COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,1RN0W@1236|Gammaproteobacteria,1WWJH@135613|Chromatiales 135613|Chromatiales E peptidase M24B, X-Pro dipeptidase aminopeptidase - - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - AMP_N,Peptidase_M24 k59_1149491_2 748247.AZKH_0923 1.26e-19 90.1 COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,2VKV7@28216|Betaproteobacteria,2KV4R@206389|Rhodocyclales 206389|Rhodocyclales CH UbiH UbiF VisC COQ6 family ubiH - - ko:K03185 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04989,R08773 RC02670 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_3 k59_851715_1 1121939.L861_21310 1.21e-18 85.5 COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,1RNDC@1236|Gammaproteobacteria,1XHCZ@135619|Oceanospirillales 135619|Oceanospirillales J Tryptophanyl-tRNA synthetase trpS - 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1b k59_851715_2 225937.HP15_2765 1e-41 140.0 2CNK3@1|root,31TH7@2|Bacteria,1R38H@1224|Proteobacteria,1S7X7@1236|Gammaproteobacteria,46DFI@72275|Alteromonadaceae 1236|Gammaproteobacteria S Protein of Unknown function (DUF2784) - - - - - - - - - - - - DUF2784 k59_1149824_1 228410.NE2402 2.97e-205 593.0 COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,2VHYF@28216|Betaproteobacteria,371VX@32003|Nitrosomonadales 28216|Betaproteobacteria O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_1149824_2 634499.EpC_23160 4.8e-40 146.0 COG3907@1|root,COG3907@2|Bacteria,1MU4M@1224|Proteobacteria,1RQ2Y@1236|Gammaproteobacteria,3X669@551|Erwinia 1236|Gammaproteobacteria S PAP2 superfamily - - - - - - - - - - - - PAP2 k59_852045_1 1121396.KB892902_gene2275 9.17e-31 125.0 COG2909@1|root,COG3629@1|root,COG2909@2|Bacteria,COG3629@2|Bacteria,1ND43@1224|Proteobacteria,42Q70@68525|delta/epsilon subdivisions,2WKU1@28221|Deltaproteobacteria,2MMVA@213118|Desulfobacterales 28221|Deltaproteobacteria KT Transcriptional regulatory protein, C terminal - - - - - - - - - - - - BTAD,Trans_reg_C k59_852050_1 1158050.KB895452_gene365 6.99e-11 62.8 COG1125@1|root,COG1125@2|Bacteria,2GJHI@201174|Actinobacteria,1W7U5@1268|Micrococcaceae 201174|Actinobacteria E ABC transporter proV - - ko:K05847 ko02010,map02010 M00209 - - ko00000,ko00001,ko00002,ko02000 3.A.1.12 - iNJ661.Rv3758c ABC_tran k59_852050_2 349124.Hhal_2305 4.85e-55 182.0 COG0552@1|root,COG0552@2|Bacteria,1MUDU@1224|Proteobacteria,1RNIN@1236|Gammaproteobacteria,1WW5G@135613|Chromatiales 135613|Chromatiales U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components ftsY - - ko:K03110 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2,3.A.5.7 - - SRP54,SRP54_N k59_1150389_1 502025.Hoch_5272 4.01e-61 198.0 COG2171@1|root,COG2171@2|Bacteria,1MU0Y@1224|Proteobacteria,42SPQ@68525|delta/epsilon subdivisions,2WPX1@28221|Deltaproteobacteria,2YWQX@29|Myxococcales 28221|Deltaproteobacteria E Belongs to the transferase hexapeptide repeat family dapD - 2.3.1.117 ko:K00674 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R04365 RC00004,RC01136 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,Hexapep_2,THDPS_N_2 k59_896958_1 420324.KI912061_gene6197 2.25e-82 273.0 COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,1JR57@119045|Methylobacteriaceae 28211|Alphaproteobacteria T Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - AAA_16,Abhydrolase_1,Guanylate_cyc,TPR_4 k59_939592_1 1206729.BAFZ01000081_gene1698 4.21e-16 82.0 COG3173@1|root,COG3173@2|Bacteria,2GSTN@201174|Actinobacteria,4FY7Q@85025|Nocardiaceae 201174|Actinobacteria S Phosphotransferase enzyme family - - - - - - - - - - - - APH k59_599093_1 196367.JNFG01000214_gene1304 3.28e-95 290.0 COG3464@1|root,COG3464@2|Bacteria,1R8HI@1224|Proteobacteria,2VT67@28216|Betaproteobacteria,1KHTC@119060|Burkholderiaceae 28216|Betaproteobacteria L Transposase - - - - - - - - - - - - DDE_Tnp_ISL3,TrfA k59_2394_1 864051.BurJ1DRAFT_4687 2.43e-22 94.4 COG1999@1|root,COG1999@2|Bacteria,1R725@1224|Proteobacteria,2W1XA@28216|Betaproteobacteria,1KNI5@119065|unclassified Burkholderiales 28216|Betaproteobacteria S SCO1/SenC - - - - - - - - - - - - SCO1-SenC k59_2394_2 247490.KSU1_D0504 4.45e-15 75.5 COG0683@1|root,COG2010@1|root,COG0683@2|Bacteria,COG2010@2|Bacteria 2|Bacteria C Cytochrome c - - - - - - - - - - - - Cytochrom_C,Peripla_BP_6 k59_896983_1 2340.JV46_16550 5.74e-97 295.0 COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,1RM7N@1236|Gammaproteobacteria,1J53B@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Aminotransferase hemL GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016853,GO:0016866,GO:0016869,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042286,GO:0042440,GO:0042802,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - iUMNK88_1353.UMNK88_158 Aminotran_3 k59_44618_1 572477.Alvin_0006 4.08e-63 206.0 COG5621@1|root,COG5621@2|Bacteria,1MUVF@1224|Proteobacteria,1RZ65@1236|Gammaproteobacteria,1WWIJ@135613|Chromatiales 135613|Chromatiales S Lipocalin-like domain - - - - - - - - - - - - CrtC,Lipocalin_9 k59_44618_2 1121127.JAFA01000010_gene3997 3.99e-53 189.0 COG0577@1|root,COG0577@2|Bacteria,1MVCT@1224|Proteobacteria,2VJAI@28216|Betaproteobacteria,1K2BP@119060|Burkholderiaceae 28216|Betaproteobacteria MV FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1195376_1 1454004.AW11_00972 1.06e-59 207.0 COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,2VHHQ@28216|Betaproteobacteria,1KQ8R@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria Q FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_939630_1 404589.Anae109_2667 1e-13 71.6 COG0685@1|root,COG0685@2|Bacteria,1MUC9@1224|Proteobacteria,42P5X@68525|delta/epsilon subdivisions,2WIQW@28221|Deltaproteobacteria 28221|Deltaproteobacteria E PFAM Methylenetetrahydrofolate reductase metF - 1.5.1.20 ko:K00297 ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523 M00377 R01224,R07168 RC00081 ko00000,ko00001,ko00002,ko01000 - - - MTHFR k59_1152809_1 1095769.CAHF01000001_gene3463 8.35e-159 458.0 COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,2VJZN@28216|Betaproteobacteria,4735T@75682|Oxalobacteraceae 28216|Betaproteobacteria C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane pntA - 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N,PNTB_4TM k59_300748_2 1443665.JACA01000003_gene641 1.7e-06 49.3 COG1028@1|root,COG1028@2|Bacteria,4NE45@976|Bacteroidetes,1HWS3@117743|Flavobacteriia,2YGNT@290174|Aquimarina 976|Bacteroidetes IQ Enoyl-(Acyl carrier protein) reductase ykuF - - ko:K13774 ko00281,map00281 - R08087,R08096,R10125,R10126 RC00080,RC00087 ko00000,ko00001 - - - adh_short_C2 k59_300748_3 402881.Plav_0450 8.67e-30 113.0 COG1028@1|root,COG1028@2|Bacteria,1PFUB@1224|Proteobacteria,2U149@28211|Alphaproteobacteria,1JQM5@119043|Rhodobiaceae 28211|Alphaproteobacteria IQ PFAM short-chain dehydrogenase reductase SDR MA20_16350 - - - - - - - - - - - adh_short_C2 k59_897012_1 338969.Rfer_1460 0.000353 48.1 COG0715@1|root,COG0715@2|Bacteria,1MVZE@1224|Proteobacteria,2VJ88@28216|Betaproteobacteria,4A9W3@80864|Comamonadaceae 28216|Betaproteobacteria P NMT1-like family - - - ko:K02051 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - NMT1,NMT1_2 k59_257607_1 713586.KB900536_gene2525 2.16e-112 333.0 COG2046@1|root,COG2046@2|Bacteria,1MUQB@1224|Proteobacteria,1RP4Q@1236|Gammaproteobacteria,1WWF2@135613|Chromatiales 135613|Chromatiales P Belongs to the sulfate adenylyltransferase family sat - 2.7.7.4 ko:K00958 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R04929 RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - ATP-sulfurylase,PUA_2 k59_683939_1 1156919.QWC_12898 2.13e-24 98.6 COG1826@1|root,COG1826@2|Bacteria,1N73F@1224|Proteobacteria,2VVPX@28216|Betaproteobacteria,3T4FJ@506|Alcaligenaceae 28216|Betaproteobacteria U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation tatB - - ko:K03117 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 k59_683939_2 864051.BurJ1DRAFT_1223 5.9e-22 87.8 COG1826@1|root,COG1826@2|Bacteria,1N6S4@1224|Proteobacteria,2VVT6@28216|Betaproteobacteria,1KMNQ@119065|unclassified Burkholderiales 28216|Betaproteobacteria U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system tatA - - ko:K03116 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 k59_811594_1 398527.Bphyt_6755 4.22e-110 344.0 COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2VHCG@28216|Betaproteobacteria,1K1HS@119060|Burkholderiaceae 28216|Betaproteobacteria C FAD linked oxidase domain protein - - - ko:K06911 - - - - ko00000 - - - CCG,FAD-oxidase_C,FAD_binding_4,Fer4_8 k59_769259_1 640081.Dsui_0749 3.56e-39 149.0 COG5000@1|root,COG5001@1|root,COG5000@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KV9J@206389|Rhodocyclales 206389|Rhodocyclales T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,PAS_4,PAS_9,dCache_1 k59_1152857_1 1095769.CAHF01000022_gene126 8.93e-63 205.0 COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VHK8@28216|Betaproteobacteria,4731A@75682|Oxalobacteraceae 28216|Betaproteobacteria S Tripartite tricarboxylate transporter family receptor - - - - - - - - - - - - TctC k59_44712_1 266265.Bxe_B0458 1.63e-76 238.0 COG2513@1|root,COG2513@2|Bacteria,1N4VT@1224|Proteobacteria,2VZBQ@28216|Betaproteobacteria,1K5FI@119060|Burkholderiaceae 28216|Betaproteobacteria G Phosphoenolpyruvate phosphomutase - - 4.1.3.32 ko:K20454 ko00760,ko01120,map00760,map01120 - R01355 RC00286,RC01810 ko00000,ko00001,ko01000 - - - PEP_mutase k59_599243_1 1469245.JFBG01000014_gene2025 1.93e-92 278.0 COG3181@1|root,COG3181@2|Bacteria,1MXEX@1224|Proteobacteria,1S9CF@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Tripartite tricarboxylate transporter family receptor - - - - - - - - - - - - TctC k59_1025534_2 1278309.KB907099_gene2917 0.000338 45.1 COG4191@1|root,COG4191@2|Bacteria,1R8JK@1224|Proteobacteria,1SC56@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Histidine kinase - - 2.7.13.3 ko:K07709 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_897079_1 555779.Dthio_PD2126 6.27e-42 144.0 COG0449@1|root,COG0449@2|Bacteria,1RGWX@1224|Proteobacteria,42TA9@68525|delta/epsilon subdivisions,2WPHJ@28221|Deltaproteobacteria 68525|delta/epsilon subdivisions M ORF6N domain - - - - - - - - - - - - ORF6N k59_385369_1 1028806.GGE_1974 3.28e-16 75.5 2EE0G@1|root,337V9@2|Bacteria,1RG3P@1224|Proteobacteria,1TFTC@1236|Gammaproteobacteria,1YA5G@135625|Pasteurellales 135625|Pasteurellales S Protein of unknown function (DUF3277) Z012_10455 - - - - - - - - - - - DUF3277 k59_1068171_1 713586.KB900536_gene2578 1.05e-32 123.0 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,1RN8G@1236|Gammaproteobacteria,1WWZV@135613|Chromatiales 135613|Chromatiales NU PFAM Type II secretion system protein E - - - - - - - - - - - - T2SSE k59_1068171_2 100226.SCO7240 3.67e-18 86.3 COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2GMPZ@201174|Actinobacteria 201174|Actinobacteria KLT serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase,TPR_10,TPR_12 k59_1195523_1 1454004.AW11_00534 4.64e-95 290.0 COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,2VH09@28216|Betaproteobacteria 28216|Betaproteobacteria H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis ubiD - 4.1.1.98 ko:K03182 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04985,R04986 RC00391 ko00000,ko00001,ko00002,ko01000 - - - UbiD k59_1195523_2 1469245.JFBG01000043_gene1905 2.6e-41 152.0 COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,1RSEQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria C indolepyruvate ferredoxin oxidoreductase - - 1.2.7.8 ko:K04090 - - - - br01601,ko00000,ko01000 - - - POR,TPP_enzyme_C k59_1025616_1 673860.AciM339_1402 4.36e-60 209.0 COG0085@1|root,arCOG01762@2157|Archaea,2XU1X@28890|Euryarchaeota,3F2FW@33867|unclassified Euryarchaeota 28890|Euryarchaeota K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB1 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03044,ko:K13798 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00184 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_4,RNA_pol_Rpb2_5,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_1152998_1 85643.Tmz1t_1798 2.46e-27 103.0 COG0818@1|root,COG0818@2|Bacteria,1MZ3Q@1224|Proteobacteria,2VU5Y@28216|Betaproteobacteria,2KWKX@206389|Rhodocyclales 206389|Rhodocyclales M Recycling of diacylglycerol produced during the turnover of membrane phospholipid - - 2.7.1.107 ko:K00901 ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00561,map00564,map01100,map01110,map04070,map04072,map05231 - R02240 RC00002,RC00017 ko00000,ko00001,ko01000 - - - DAGK_prokar k59_1152998_2 365044.Pnap_2211 2.47e-44 150.0 COG2062@1|root,COG2062@2|Bacteria,1RIVH@1224|Proteobacteria,2VSSQ@28216|Betaproteobacteria,4ADWN@80864|Comamonadaceae 28216|Betaproteobacteria T PFAM Phosphoglycerate mutase sixA - - ko:K08296 - - - - ko00000,ko01000 - - - His_Phos_1 k59_385474_1 1485544.JQKP01000005_gene308 7.09e-25 98.2 COG0425@1|root,COG0425@2|Bacteria,1PX23@1224|Proteobacteria,2WCJT@28216|Betaproteobacteria,44W8S@713636|Nitrosomonadales 28216|Betaproteobacteria O Sulfurtransferase TusA - - - - - - - - - - - - TusA k59_385474_2 1123392.AQWL01000006_gene707 1.19e-38 139.0 2CB8R@1|root,2Z90U@2|Bacteria,1R4DV@1224|Proteobacteria,2VZZT@28216|Betaproteobacteria,1KSKS@119069|Hydrogenophilales 119069|Hydrogenophilales - - - - - - - - - - - - - - - k59_1323556_1 1187851.A33M_4207 9.24e-98 291.0 COG0543@1|root,COG0543@2|Bacteria 2|Bacteria C 2 iron, 2 sulfur cluster binding gltA - 1.18.1.2,1.19.1.1,1.4.1.13,1.4.1.14 ko:K00266,ko:K00528,ko:K02823 ko00240,ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00240,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248,R10159 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - DHODB_Fe-S_bind,FAD_binding_6,Fer4_20,NAD_binding_1,Pyr_redox_2 k59_854401_1 1382356.JQMP01000003_gene2449 2.47e-09 60.5 COG4454@1|root,COG4454@2|Bacteria,2GA6H@200795|Chloroflexi,27YMB@189775|Thermomicrobia 189775|Thermomicrobia P Copper binding proteins, plastocyanin/azurin family - - - - - - - - - - - - Cupredoxin_1 k59_1025730_1 1163617.SCD_n02069 3.89e-93 286.0 COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,2VKNG@28216|Betaproteobacteria 28216|Betaproteobacteria J SMART PUA domain containing protein rlmI - 2.1.1.191 ko:K06969 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_SAM k59_343207_1 1095769.CAHF01000022_gene339 2.21e-47 165.0 COG4966@1|root,COG4966@2|Bacteria,1RC4Q@1224|Proteobacteria,2VS7N@28216|Betaproteobacteria,476YR@75682|Oxalobacteraceae 28216|Betaproteobacteria NU Type IV Pilus-assembly protein W pilW - - ko:K02672 - - - - ko00000,ko02035,ko02044 - - - N_methyl,PilW k59_2757_2 1089552.KI911559_gene2018 2.05e-123 359.0 COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,2JV4G@204441|Rhodospirillales 204441|Rhodospirillales L HTH-like domain - - - - - - - - - - - - HTH_21,rve_3 k59_257812_1 1121861.KB899922_gene3091 2.23e-53 183.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2TQWP@28211|Alphaproteobacteria,2JQ0B@204441|Rhodospirillales 204441|Rhodospirillales E Gamma-glutamyltranspeptidase - - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_257812_2 331869.BAL199_01664 1.16e-52 182.0 COG0069@1|root,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,2TREH@28211|Alphaproteobacteria,4BRFG@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E Conserved region in glutamate synthase MA20_40290 - - - - - - - - - - - Glu_synthase k59_301074_1 1229909.NSED_06870 1.2e-31 119.0 COG0109@1|root,arCOG00479@2157|Archaea,41SDQ@651137|Thaumarchaeota 651137|Thaumarchaeota H Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group - - 2.5.1.141 ko:K02257 ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714 M00154 R07411 RC01786 ko00000,ko00001,ko00002,ko01000,ko01006,ko03029 - - - UbiA k59_301074_2 436308.Nmar_1226 2.03e-49 167.0 COG3794@1|root,arCOG02926@2157|Archaea,arCOG02929@2157|Archaea,41SHN@651137|Thaumarchaeota 651137|Thaumarchaeota C PFAM blue (type 1) copper domain protein - - - - - - - - - - - - Copper-bind k59_854445_1 1121033.AUCF01000006_gene4053 1.58e-90 278.0 COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,2TRP9@28211|Alphaproteobacteria,2JQM7@204441|Rhodospirillales 204441|Rhodospirillales P Potassium transporter peripheral membrane component trkA - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N k59_172709_2 1472716.KBK24_0108770 7.63e-22 93.6 COG0466@1|root,COG0466@2|Bacteria,1MWQ9@1224|Proteobacteria,2VJKY@28216|Betaproteobacteria,1K3YV@119060|Burkholderiaceae 28216|Betaproteobacteria O PFAM AAA ATPase central domain protein - - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA k59_513702_1 225849.swp_3095 9.81e-58 202.0 COG0642@1|root,COG2205@2|Bacteria,1N17V@1224|Proteobacteria,1RNFK@1236|Gammaproteobacteria,2QABE@267890|Shewanellaceae 1236|Gammaproteobacteria T histidine kinase HAMP region domain protein - - 2.7.13.3 ko:K07641 ko02020,map02020 M00449 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_2818_1 596153.Alide_0778 1.75e-11 62.4 COG1876@1|root,COG1876@2|Bacteria,1NAYN@1224|Proteobacteria,2VW00@28216|Betaproteobacteria 28216|Betaproteobacteria M D-alanyl-D-alanine carboxypeptidase - - - ko:K17733 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_M15_4,VanY k59_982580_1 1094508.Tsac_0905 3.53e-13 72.8 COG2084@1|root,COG2084@2|Bacteria,1UM9K@1239|Firmicutes,25GCT@186801|Clostridia,42J7Z@68295|Thermoanaerobacterales 186801|Clostridia C NAD NADP octopine nopaline dehydrogenase - - 1.5.1.28 ko:K04940 - - - - ko00000,ko01000 - - - NAD_binding_2,Octopine_DH k59_1323683_1 977880.RALTA_A1678 1.49e-41 152.0 COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,2VIBP@28216|Betaproteobacteria,1K18S@119060|Burkholderiaceae 28216|Betaproteobacteria M Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxB - 2.4.1.182 ko:K00748 ko00540,ko01100,map00540,map01100 M00060 R04606 RC00005,RC00059 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT19 - LpxB k59_726858_1 518766.Rmar_1656 2.59e-67 228.0 COG0019@1|root,COG0527@1|root,COG0019@2|Bacteria,COG0527@2|Bacteria,4NFWR@976|Bacteroidetes,1FIKN@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes E Belongs to the Orn Lys Arg decarboxylase class-II family - - 2.7.2.4,4.1.1.20 ko:K00928,ko:K12526 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00451,R00480 RC00002,RC00043,RC00299 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_1191838_1 1125971.ASJB01000083_gene1516 2.54e-27 114.0 COG3509@1|root,COG3509@2|Bacteria,2GNV6@201174|Actinobacteria,4E37Q@85010|Pseudonocardiales 201174|Actinobacteria Q Poly(3-hydroxybutyrate) depolymerase - - - ko:K03932 - - - - ko00000 - CE1 - Esterase_phd k59_552345_1 485916.Dtox_2289 8.55e-46 167.0 COG0608@1|root,COG0608@2|Bacteria,1TPXE@1239|Firmicutes,247NU@186801|Clostridia,25ZYA@186807|Peptococcaceae 186801|Clostridia L TIGRFAM single-stranded-DNA-specific exonuclease RecJ recJ - - ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1,Helicase_C k59_552362_1 402881.Plav_2798 1.47e-132 400.0 COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,2TQUZ@28211|Alphaproteobacteria,1JNFE@119043|Rhodobiaceae 28211|Alphaproteobacteria O C-terminal, D2-small domain, of ClpB protein clpA GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043335,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 - ko:K03694 - - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_1319699_1 983917.RGE_00680 5e-116 342.0 COG0722@1|root,COG0722@2|Bacteria,1MU5Q@1224|Proteobacteria,2VH4W@28216|Betaproteobacteria,1KJN3@119065|unclassified Burkholderiales 28216|Betaproteobacteria E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) - - 2.5.1.54 ko:K01626 ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - - DAHP_synth_1 k59_552435_1 1454004.AW11_00785 3.38e-50 172.0 COG0795@1|root,COG0795@2|Bacteria,1MVW3@1224|Proteobacteria,2VHA1@28216|Betaproteobacteria,1KQ9Q@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria S Predicted permease YjgP/YjgQ family lptG - - ko:K11720 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_592834_1 243090.RB8684 0.000476 42.7 COG3367@1|root,COG3367@2|Bacteria,2IWX8@203682|Planctomycetes 203682|Planctomycetes S Domain of unknown function (DUF1611_N) Rossmann-like domain - - - - - - - - - - - - DUF1611,DUF1611_N k59_592834_2 768710.DesyoDRAFT_4612 1.7e-28 114.0 COG0438@1|root,COG0438@2|Bacteria,1TPS8@1239|Firmicutes,25EPJ@186801|Clostridia,261ES@186807|Peptococcaceae 186801|Clostridia M PFAM Glycosyl - - - ko:K00754 - - - - ko00000,ko01000 - GT4 - Glyco_transf_4,Glycos_transf_1 k59_166360_1 1095769.CAHF01000011_gene2682 6.09e-153 443.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,4733N@75682|Oxalobacteraceae 28216|Betaproteobacteria T Sigma-54 interaction domain ntrC GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0043565,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141 - ko:K07712 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_1143619_1 314231.FP2506_17909 2.71e-44 156.0 2C7F6@1|root,2Z8AK@2|Bacteria,1PEE5@1224|Proteobacteria,2TTH2@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_1143619_2 1000565.METUNv1_02594 6.83e-30 111.0 COG1403@1|root,COG1403@2|Bacteria,1MWEQ@1224|Proteobacteria,2VKQH@28216|Betaproteobacteria,2KW5S@206389|Rhodocyclales 206389|Rhodocyclales L HNH endonuclease - - - - - - - - - - - - HNH_5 k59_1192006_1 583345.Mmol_0477 6.12e-56 191.0 COG0845@1|root,COG0845@2|Bacteria,1MUI8@1224|Proteobacteria,2VIAA@28216|Betaproteobacteria,2KNM2@206350|Nitrosomonadales 206350|Nitrosomonadales M TIGRFAM type I secretion membrane fusion protein, HlyD family - - - ko:K02022 - - - - ko00000 - - - HlyD,HlyD_3 k59_978612_1 631454.N177_3632 5.5e-37 135.0 COG1893@1|root,COG1893@2|Bacteria,1QMH8@1224|Proteobacteria,2TSGW@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid - - - - - - - - - - - - - k59_557313_1 631454.N177_0653 4.66e-27 105.0 COG0559@1|root,COG0559@2|Bacteria,1MY1E@1224|Proteobacteria,2U0TW@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the binding-protein-dependent transport system permease family - - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_557313_2 1504672.669784905 5.9e-74 246.0 COG1129@1|root,COG4177@1|root,COG1129@2|Bacteria,COG4177@2|Bacteria,1R9IW@1224|Proteobacteria,2VKMT@28216|Betaproteobacteria,4AK08@80864|Comamonadaceae 28216|Betaproteobacteria P Belongs to the binding-protein-dependent transport system permease family - - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C,BPD_transp_2 k59_88455_1 292415.Tbd_2130 2.63e-90 276.0 COG1194@1|root,COG1194@2|Bacteria,1MUD4@1224|Proteobacteria,2VH21@28216|Betaproteobacteria,1KRJI@119069|Hydrogenophilales 119069|Hydrogenophilales L NUDIX domain - - - ko:K03575 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - HhH-GPD,NUDIX_4 k59_88455_2 1380394.JADL01000004_gene5911 3.39e-81 253.0 COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,2TR5B@28211|Alphaproteobacteria,2JPY3@204441|Rhodospirillales 204441|Rhodospirillales S Psort location Cytoplasmic, score 7.50 - - - - - - - - - - - - M20_dimer,Peptidase_M20 k59_812928_1 397945.Aave_3965 4.56e-96 295.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VI4Q@28216|Betaproteobacteria,4A9SZ@80864|Comamonadaceae 28216|Betaproteobacteria O Belongs to the peptidase S1C family mucD - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_1196967_1 948106.AWZT01000015_gene714 1.83e-41 151.0 COG0277@1|root,COG0277@2|Bacteria,1MUPW@1224|Proteobacteria,2VI8J@28216|Betaproteobacteria,1K4EB@119060|Burkholderiaceae 28216|Betaproteobacteria C PFAM FAD linked oxidase domain protein - - - - - - - - - - - - BBE,FAD_binding_4 k59_46496_1 1123401.JHYQ01000009_gene2254 2.28e-56 185.0 COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,1RMJJ@1236|Gammaproteobacteria,462D8@72273|Thiotrichales 72273|Thiotrichales KT LytTr DNA-binding domain - - - ko:K08083 ko02020,map02020 M00493 - - ko00000,ko00001,ko00002,ko02022 - - - LytTR,Response_reg k59_855613_1 438753.AZC_1421 4.2e-52 187.0 COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,3EYFT@335928|Xanthobacteraceae 28211|Alphaproteobacteria T PAS fold - - - - - - - - - - - - GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,Response_reg k59_1282101_1 469618.FVAG_00036 1.02e-56 186.0 COG0171@1|root,COG0171@2|Bacteria,378BE@32066|Fusobacteria 32066|Fusobacteria H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source nadE GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.1.5 ko:K01916 ko00760,ko01100,map00760,map01100 M00115 R00189 RC00100 ko00000,ko00001,ko00002,ko01000 - - - NAD_synthase k59_515011_1 1380391.JIAS01000017_gene458 3.09e-62 196.0 COG0194@1|root,COG0194@2|Bacteria,1MW92@1224|Proteobacteria,2TSCQ@28211|Alphaproteobacteria,2JPXS@204441|Rhodospirillales 204441|Rhodospirillales F Essential for recycling GMP and indirectly, cGMP gmk - 2.7.4.8 ko:K00942 ko00230,ko01100,map00230,map01100 M00050 R00332,R02090 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_kin k59_515011_2 414684.RC1_1559 1.28e-22 94.0 COG1561@1|root,COG1561@2|Bacteria,1MWRA@1224|Proteobacteria,2TS81@28211|Alphaproteobacteria,2JPK7@204441|Rhodospirillales 204441|Rhodospirillales S Domain of unknown function (DUF1732) - - - - - - - - - - - - DUF1732,YicC_N k59_898610_1 1231391.AMZF01000006_gene2781 1.76e-52 176.0 COG4177@1|root,COG4177@2|Bacteria,1NPII@1224|Proteobacteria,2VNRM@28216|Betaproteobacteria 28216|Betaproteobacteria E Belongs to the binding-protein-dependent transport system permease family - - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_941241_1 323848.Nmul_A2423 3.73e-144 417.0 COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,2VHCK@28216|Betaproteobacteria,372A2@32003|Nitrosomonadales 28216|Betaproteobacteria K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons hrcA - - ko:K03705 - - - - ko00000,ko03000 - - - HrcA,HrcA_DNA-bdg k59_941241_2 557598.LHK_02404 8.27e-30 117.0 COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,2VH7Z@28216|Betaproteobacteria,2KPE7@206351|Neisseriales 206351|Neisseriales H Catalyzes the ferrous insertion into protoporphyrin IX hemH - 4.99.1.1,4.99.1.9 ko:K01772 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R00310,R11329 RC01012 ko00000,ko00001,ko00002,ko01000 - - - Ferrochelatase k59_728130_1 331869.BAL199_14207 1.18e-132 388.0 COG4948@1|root,COG4948@2|Bacteria,1MURK@1224|Proteobacteria,2TRS9@28211|Alphaproteobacteria,4BS1H@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria M Mandelate racemase / muconate lactonizing enzyme, C-terminal domain MA20_35850 - - - - - - - - - - - MR_MLE_C,MR_MLE_N k59_728130_2 1318628.MARLIPOL_16284 1.37e-12 67.4 2CDFF@1|root,32RXP@2|Bacteria,1N26W@1224|Proteobacteria,1SUQW@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_344851_1 926569.ANT_27800 2.26e-42 152.0 COG3385@1|root,COG3385@2|Bacteria 2|Bacteria L transposase activity - - - - - - - - - - - - DDE_Tnp_1 k59_1070107_1 1227454.C446_04825 3.58e-06 53.9 COG0451@1|root,arCOG04468@2157|Archaea,2XT9R@28890|Euryarchaeota,23RWQ@183963|Halobacteria 183963|Halobacteria M COG0451 Nucleoside-diphosphate-sugar epimerases - - - - - - - - - - - - Epimerase k59_88558_1 1000565.METUNv1_00294 8.12e-79 243.0 COG3496@1|root,COG3496@2|Bacteria,1RC56@1224|Proteobacteria,2VIZ9@28216|Betaproteobacteria,2KW5G@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function (DUF1365) - - - ko:K09701 - - - - ko00000 - - - DUF1365 k59_131116_1 1166018.FAES_0331 1.4e-81 249.0 COG3967@1|root,COG3967@2|Bacteria,4NJUM@976|Bacteroidetes,47MKC@768503|Cytophagia 976|Bacteroidetes M KR domain - - - ko:K14189 - - - - ko00000,ko01000 - - - adh_short k59_1325303_1 1120949.KB903294_gene4133 2.4e-64 221.0 COG2319@1|root,COG2319@2|Bacteria,2IH3S@201174|Actinobacteria,4DM0Y@85008|Micromonosporales 201174|Actinobacteria S MTH538 TIR-like domain (DUF1863) - - - - - - - - - - - - ANAPC4_WD40,PD40,TIR_2,WD40 k59_302882_1 288000.BBta_2284 4.98e-133 384.0 COG1063@1|root,COG1063@2|Bacteria,1MW6Y@1224|Proteobacteria,2TSUK@28211|Alphaproteobacteria,3JWGG@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Alcohol dehydrogenase GroES-like domain - - - - - - - - - - - - ADH_N,ADH_zinc_N k59_813042_1 1158292.JPOE01000005_gene1173 2.02e-57 193.0 COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,2VJ00@28216|Betaproteobacteria,1KJWP@119065|unclassified Burkholderiales 28216|Betaproteobacteria M cyclopropane-fatty-acyl-phospholipid synthase cfa GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008168,GO:0008610,GO:0008757,GO:0009058,GO:0009059,GO:0009273,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0019752,GO:0030312,GO:0032259,GO:0032787,GO:0034645,GO:0042546,GO:0043170,GO:0043436,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0070589,GO:0071554,GO:0071704,GO:0071766,GO:0071767,GO:0071768,GO:0071840,GO:0071944,GO:0072330,GO:1901576 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - - CMAS k59_302897_1 795797.C497_07164 1.76e-29 117.0 COG1804@1|root,arCOG02304@2157|Archaea,2XVRQ@28890|Euryarchaeota,23U8G@183963|Halobacteria 183963|Halobacteria C acyl-CoA transferases carnitine dehydratase - - - - - - - - - - - - CoA_transf_3 k59_1027612_1 265072.Mfla_2514 5.5e-111 334.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,2VJ8B@28216|Betaproteobacteria,2KKII@206350|Nitrosomonadales 206350|Nitrosomonadales P Ammonium Transporter - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_941363_1 886293.Sinac_5868 2.46e-30 120.0 COG3386@1|root,COG3386@2|Bacteria,2IXZT@203682|Planctomycetes 203682|Planctomycetes G gluconolactonase - - 3.1.1.17 ko:K01053 ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220 M00129 R01519,R02933,R03751 RC00537,RC00983 ko00000,ko00001,ko00002,ko01000,ko04147 - - - SGL k59_728253_1 999541.bgla_1g05210 4.69e-36 124.0 COG0211@1|root,COG0211@2|Bacteria,1MZGH@1224|Proteobacteria,2VU4W@28216|Betaproteobacteria,1K8IM@119060|Burkholderiaceae 28216|Betaproteobacteria J Belongs to the bacterial ribosomal protein bL27 family rpmA - - ko:K02899 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27 k59_728253_2 640081.Dsui_0163 1.32e-32 115.0 COG0261@1|root,COG0261@2|Bacteria,1MZEW@1224|Proteobacteria,2VSHZ@28216|Betaproteobacteria,2KWM1@206389|Rhodocyclales 206389|Rhodocyclales J This protein binds to 23S rRNA in the presence of protein L20 rplU - - ko:K02888 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L21p k59_1027652_1 926556.Echvi_3203 2.39e-26 113.0 COG3385@1|root,COG5421@1|root,COG3385@2|Bacteria,COG5421@2|Bacteria,4NXT2@976|Bacteroidetes 976|Bacteroidetes L hmm pf01609 - - - - - - - - - - - - DDE_Tnp_1_4 k59_601345_1 187272.Mlg_2802 9.23e-115 335.0 COG0451@1|root,COG0451@2|Bacteria,1MXKV@1224|Proteobacteria,1RNJD@1236|Gammaproteobacteria,1WX9A@135613|Chromatiales 135613|Chromatiales GM PFAM NAD-dependent epimerase dehydratase - - 4.1.1.35 ko:K08678 ko00520,ko01100,map00520,map01100 M00361 R01384 RC00508 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd k59_1111522_1 1288494.EBAPG3_2050 6.25e-37 124.0 COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,2VVTG@28216|Betaproteobacteria,373I5@32003|Nitrosomonadales 28216|Betaproteobacteria K PFAM Cold-shock protein, DNA-binding - - - ko:K03704 - - - - ko00000,ko03000 - - - CSD k59_1111522_2 391613.RTM1035_15822 3.84e-18 78.6 COG2127@1|root,COG2127@2|Bacteria,1MZU8@1224|Proteobacteria,2U982@28211|Alphaproteobacteria,46QV8@74030|Roseovarius 28211|Alphaproteobacteria S Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation clpS - - ko:K06891 - - - - ko00000 - - - ClpS k59_515245_1 935866.JAER01000040_gene495 5.76e-33 121.0 COG1846@1|root,COG1846@2|Bacteria,2GJ6W@201174|Actinobacteria,4DQK5@85009|Propionibacteriales 201174|Actinobacteria K helix_turn_helix multiple antibiotic resistance protein pecS - - - - - - - - - - - MarR,MarR_2 k59_515245_2 1453501.JELR01000002_gene529 2.93e-42 153.0 COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,1RMT7@1236|Gammaproteobacteria,466B9@72275|Alteromonadaceae 1236|Gammaproteobacteria S Bacterial protein of unknown function (DUF885) - - - - - - - - - - - - DUF885 k59_430016_1 864073.HFRIS_004413 1.05e-132 384.0 COG0726@1|root,COG0726@2|Bacteria,1MV3V@1224|Proteobacteria,2VID2@28216|Betaproteobacteria,477IZ@75682|Oxalobacteraceae 28216|Betaproteobacteria G deacetylase - - - - - - - - - - - - Polysacc_deac_1 k59_430016_2 1123354.AUDR01000012_gene1779 1.09e-89 268.0 COG0560@1|root,COG0560@2|Bacteria,1MZPG@1224|Proteobacteria,2VHDT@28216|Betaproteobacteria 28216|Betaproteobacteria E phosphoserine phosphatase thrH - 2.7.1.39,3.1.3.3 ko:K02203 ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00680,map01100,map01110,map01120,map01130,map01230 M00018 R00582,R01771 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - HAD,Hydrolase k59_1070326_1 1038860.AXAP01000063_gene2455 9.86e-67 214.0 COG1052@1|root,COG1052@2|Bacteria,1MVSS@1224|Proteobacteria,2TR35@28211|Alphaproteobacteria,3JQNA@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria CH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family MA20_14995 - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C k59_941476_1 640510.BC1001_4023 1.35e-26 107.0 COG4447@1|root,COG4447@2|Bacteria,1ND1J@1224|Proteobacteria,2VMA5@28216|Betaproteobacteria,1K2TY@119060|Burkholderiaceae 28216|Betaproteobacteria S protein related to plant photosystem II stability assembly factor - - - - - - - - - - - - - k59_941476_2 95619.PM1_0223470 1.99e-27 102.0 COG1977@1|root,COG1977@2|Bacteria,1N6RG@1224|Proteobacteria,1SHV8@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin - - - - - - - - - - - - ThiS k59_941476_3 1123392.AQWL01000001_gene1483 1.12e-07 52.0 COG0655@1|root,COG0655@2|Bacteria,1MW7N@1224|Proteobacteria,2VJMC@28216|Betaproteobacteria,1KSQW@119069|Hydrogenophilales 119069|Hydrogenophilales S NADPH-dependent FMN reductase - - 1.6.5.2 ko:K03809 ko00130,ko01110,map00130,map01110 - R02964,R03643,R03816 RC00819 ko00000,ko00001,ko01000 - - - FMN_red k59_345086_1 426114.THI_2207 1.47e-12 67.0 COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1MU9U@1224|Proteobacteria,2VJ8C@28216|Betaproteobacteria,1KJCK@119065|unclassified Burkholderiales 28216|Betaproteobacteria H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source nadE - 6.3.1.5,6.3.5.1 ko:K01916,ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00189,R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase,NAD_synthase k59_345086_2 1266925.JHVX01000005_gene1922 2.21e-57 180.0 COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,2VSEZ@28216|Betaproteobacteria,373C4@32003|Nitrosomonadales 28216|Betaproteobacteria K Nitrogen regulatory protein P-II - - - ko:K04751 ko02020,map02020 - - - ko00000,ko00001 - - - P-II k59_345086_3 1005048.CFU_2719 1.32e-15 73.9 COG2840@1|root,COG2840@2|Bacteria,1RH34@1224|Proteobacteria,2VQ2S@28216|Betaproteobacteria,472P7@75682|Oxalobacteraceae 28216|Betaproteobacteria S Small MutS-related domain smrA - - - - - - - - - - - Smr k59_4790_1 1266925.JHVX01000008_gene367 3.93e-86 268.0 COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,2VHH0@28216|Betaproteobacteria,372M3@32003|Nitrosomonadales 28216|Betaproteobacteria L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA - - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k59_4790_2 1454004.AW11_00003 1.26e-108 326.0 COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,2VH9B@28216|Betaproteobacteria,1KPTT@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria dnaN - 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3 k59_771410_1 1297742.A176_05808 1.27e-95 296.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,42MHP@68525|delta/epsilon subdivisions,2WJY2@28221|Deltaproteobacteria,2Z30F@29|Myxococcales 28221|Deltaproteobacteria I Acetyl-coenzyme A synthetase N-terminus - - 6.2.1.17 ko:K01908 ko00640,ko01100,map00640,map01100 - R00926,R01354 RC00004,RC00043,RC00070,RC02816 ko00000,ko00001,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_430048_1 935836.JAEL01000029_gene3615 4.64e-15 79.7 COG0477@1|root,COG2814@2|Bacteria,1TRUT@1239|Firmicutes,4HEF9@91061|Bacilli,1ZFSU@1386|Bacillus 91061|Bacilli EGP Transmembrane secretion effector - - - - - - - - - - - - MFS_1,MFS_3 k59_4798_1 159087.Daro_0318 6.33e-60 185.0 COG0051@1|root,COG0051@2|Bacteria,1RGWF@1224|Proteobacteria,2VSDQ@28216|Betaproteobacteria,2KWNB@206389|Rhodocyclales 206389|Rhodocyclales J Involved in the binding of tRNA to the ribosomes rpsJ - - ko:K02946 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S10 k59_4798_2 76114.ebA3828 3.39e-71 219.0 COG0087@1|root,COG0087@2|Bacteria,1MUST@1224|Proteobacteria,2VJ3V@28216|Betaproteobacteria,2KV3R@206389|Rhodocyclales 206389|Rhodocyclales J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit rplC - - ko:K02906 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L3 k59_984157_1 631454.N177_1059 2.39e-83 259.0 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQNK@28211|Alphaproteobacteria,1JNDR@119043|Rhodobiaceae 28211|Alphaproteobacteria G Tripartite ATP-independent periplasmic transporter, DctM component - - - - - - - - - - - - DctM k59_813198_1 158500.BV97_00706 7.23e-94 281.0 COG1024@1|root,COG1024@2|Bacteria,1MWF6@1224|Proteobacteria,2TVBC@28211|Alphaproteobacteria,2K0JE@204457|Sphingomonadales 204457|Sphingomonadales I enoyl-CoA hydratase - - - - - - - - - - - - ECH_1 k59_1027843_1 222534.KB893757_gene4210 6.41e-19 90.5 COG3547@1|root,COG3547@2|Bacteria,2IBF5@201174|Actinobacteria,4ERQ9@85013|Frankiales 201174|Actinobacteria L Transposase - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_984204_1 977880.RALTA_A0395 1.81e-33 127.0 COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,2VHKQ@28216|Betaproteobacteria,1K0F2@119060|Burkholderiaceae 28216|Betaproteobacteria J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) aspS - 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GAD,tRNA-synt_2,tRNA_anti-codon k59_984204_2 479435.Kfla_2851 2.16e-30 112.0 COG4290@1|root,COG4290@2|Bacteria,2IHPV@201174|Actinobacteria,4DRWI@85009|Propionibacteriales 201174|Actinobacteria F ribonuclease - - 3.1.27.3 ko:K01167 - - - - ko00000,ko01000,ko03016,ko03019 - - - Ribonuclease k59_387034_1 331869.BAL199_06164 6.71e-103 315.0 COG0477@1|root,COG2814@2|Bacteria,1MUDA@1224|Proteobacteria,2TS0P@28211|Alphaproteobacteria 28211|Alphaproteobacteria EGP Major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_1070461_1 1028800.RG540_CH13710 2.67e-114 349.0 COG0305@1|root,COG0358@1|root,COG0305@2|Bacteria,COG0358@2|Bacteria,1QT52@1224|Proteobacteria,2TVNI@28211|Alphaproteobacteria,4BIA7@82115|Rhizobiaceae 28211|Alphaproteobacteria L Toprim-like - - 3.6.4.12 ko:K17680 - - - - ko00000,ko01000,ko03029 - - - DnaB_C,Toprim_2 k59_601608_1 28229.ND2E_2641 2.38e-61 206.0 COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,1RNZE@1236|Gammaproteobacteria,2Q5WK@267889|Colwelliaceae 1236|Gammaproteobacteria D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase tig GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006464,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0036211,GO:0042802,GO:0043021,GO:0043022,GO:0043170,GO:0043335,GO:0043412,GO:0044183,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0050896,GO:0051083,GO:0061077,GO:0071704,GO:0140096,GO:1901564 - ko:K03545 - - - - ko00000 - - - FKBP_C,Trigger_C,Trigger_N k59_984240_1 1123279.ATUS01000001_gene2453 1.44e-93 292.0 COG2067@1|root,COG2067@2|Bacteria,1PXPC@1224|Proteobacteria,1RQKS@1236|Gammaproteobacteria,1JC29@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Protein of unknown function (DUF3570) - - - - - - - - - - - - DUF3570 k59_46975_1 207954.MED92_17595 5.56e-27 103.0 COG0858@1|root,COG0858@2|Bacteria,1MZPE@1224|Proteobacteria,1S9AF@1236|Gammaproteobacteria,1XKKG@135619|Oceanospirillales 135619|Oceanospirillales J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA rbfA - - ko:K02834 - - - - ko00000,ko03009 - - - RBFA k59_46975_2 1255043.TVNIR_3110 6.49e-24 99.8 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,1RM9X@1236|Gammaproteobacteria,1WVXH@135613|Chromatiales 135613|Chromatiales J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc k59_855964_1 1097668.BYI23_A024510 6.39e-21 86.3 COG0049@1|root,COG0049@2|Bacteria,1MXC8@1224|Proteobacteria,2VQ63@28216|Betaproteobacteria,1K1QQ@119060|Burkholderiaceae 28216|Betaproteobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA rpsG - - ko:K02992 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S7 k59_855964_2 1276756.AUEX01000002_gene636 1.63e-169 493.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,2VI3Q@28216|Betaproteobacteria,4AAAN@80864|Comamonadaceae 28216|Betaproteobacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_941608_1 1380394.JADL01000004_gene5869 2.19e-28 115.0 COG5276@1|root,COG5276@2|Bacteria,1MU72@1224|Proteobacteria,2TZVG@28211|Alphaproteobacteria,2JUDH@204441|Rhodospirillales 204441|Rhodospirillales L Secreted protein containing C-terminal beta-propeller domain distantly related to WD-40 repeats - - - - - - - - - - - - LVIVD k59_303287_2 994479.GL877884_gene7706 1.11e-05 49.7 COG1051@1|root,COG1051@2|Bacteria,2I8YY@201174|Actinobacteria,4E3P1@85010|Pseudonocardiales 201174|Actinobacteria F NUDIX domain - - - - - - - - - - - - NUDIX k59_52820_1 706587.Desti_2026 6.95e-39 148.0 COG4262@1|root,COG4262@2|Bacteria,1QX9D@1224|Proteobacteria,42Q62@68525|delta/epsilon subdivisions,2WMHX@28221|Deltaproteobacteria 28221|Deltaproteobacteria E Spermine spermidine synthase - - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synth k59_1202090_1 1049564.TevJSym_ax00490 3.48e-75 251.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1J5F8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran k59_434894_1 1288494.EBAPG3_7950 1.21e-64 219.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,2VI8N@28216|Betaproteobacteria,3725J@32003|Nitrosomonadales 28216|Betaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_1331393_1 748247.AZKH_p0418 8.33e-45 166.0 28HYC@1|root,2Z83T@2|Bacteria,1QEBM@1224|Proteobacteria,2VPIF@28216|Betaproteobacteria,2KYJU@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_1244785_1 1415780.JPOG01000001_gene2720 1.86e-09 58.2 COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,1RR68@1236|Gammaproteobacteria,1X46A@135614|Xanthomonadales 135614|Xanthomonadales H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate moaA - 4.1.99.22 ko:K03639 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09394 RC03420 ko00000,ko00001,ko01000 - - - Fer4_12,Mob_synth_C,Radical_SAM k59_1244785_2 1000565.METUNv1_04051 7.32e-91 274.0 COG1526@1|root,COG1526@2|Bacteria,1MY28@1224|Proteobacteria,2VK94@28216|Betaproteobacteria,2KV23@206389|Rhodocyclales 206389|Rhodocyclales C Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH fdhD - - ko:K02379 - - - - ko00000 - - - FdhD-NarQ k59_1076215_1 1300345.LF41_1123 5.07e-68 213.0 COG5395@1|root,COG5395@2|Bacteria,1REYE@1224|Proteobacteria,1S5R8@1236|Gammaproteobacteria,1XBEU@135614|Xanthomonadales 135614|Xanthomonadales S Predicted membrane protein (DUF2306) - - - - - - - - - - - - DUF2306 k59_777294_1 204773.HEAR0348 9.32e-97 290.0 COG3181@1|root,COG3181@2|Bacteria,1MXEX@1224|Proteobacteria,2VKSV@28216|Betaproteobacteria,4765G@75682|Oxalobacteraceae 28216|Betaproteobacteria S Tripartite tricarboxylate transporter family receptor - - - - - - - - - - - - TctC k59_1159506_1 519989.ECTPHS_02666 7.85e-79 246.0 COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,1RN2A@1236|Gammaproteobacteria,1WWZ0@135613|Chromatiales 135613|Chromatiales E The glycine cleavage system catalyzes the degradation of glycine gcvT - 2.1.2.10 ko:K00605 ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 M00532 R01221,R02300,R04125 RC00022,RC00069,RC00183,RC02834 ko00000,ko00001,ko00002,ko01000 - - - GCV_T,GCV_T_C k59_1331451_1 1097668.BYI23_C002820 5.86e-75 236.0 COG3435@1|root,COG3435@2|Bacteria,1MVJP@1224|Proteobacteria,2VM1T@28216|Betaproteobacteria,1JZPS@119060|Burkholderiaceae 28216|Betaproteobacteria Q Gentisate 1,2-dioxygenase - - 1.13.11.4 ko:K00450 ko00350,ko01100,ko01120,map00350,map01100,map01120 - R02656 RC00764 ko00000,ko00001,ko01000 - - - Cupin_2 k59_1331500_1 1229780.BN381_400004 2.48e-08 57.4 COG1678@1|root,COG1678@2|Bacteria,2GNRA@201174|Actinobacteria,3UXIP@52018|unclassified Actinobacteria (class) 201174|Actinobacteria K Uncharacterized ACR, COG1678 - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K07735 - - - - ko00000,ko03000 - - - DUF179 k59_1331500_2 296591.Bpro_3939 1.66e-29 110.0 COG1077@1|root,COG1077@2|Bacteria,1RK8H@1224|Proteobacteria,2VT45@28216|Betaproteobacteria,4AESU@80864|Comamonadaceae 28216|Betaproteobacteria D MreB/Mbl protein - - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl k59_309107_1 1240349.ANGC01000026_gene3728 1.04e-87 288.0 COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,2I2RH@201174|Actinobacteria,4G8NE@85025|Nocardiaceae 201174|Actinobacteria IQ AMP-binding enzyme - - - ko:K12428 - - - - ko00000,ko01004 - - - AMP-binding,Acyltransferase,PP-binding k59_946400_2 1168065.DOK_12296 4.74e-31 120.0 COG2084@1|root,COG2084@2|Bacteria,1MX8V@1224|Proteobacteria,1RW94@1236|Gammaproteobacteria,1JANY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases - - - - - - - - - - - - DUF1932,NAD_binding_2 k59_435023_1 1408164.MOLA814_01288 9.22e-58 195.0 COG0668@1|root,COG0668@2|Bacteria,1MXH4@1224|Proteobacteria,2VM0E@28216|Betaproteobacteria 28216|Betaproteobacteria M Conserved TM helix - - - - - - - - - - - - TM_helix k59_607504_1 1304883.KI912532_gene772 1.26e-83 267.0 COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,2VINT@28216|Betaproteobacteria,2KVAV@206389|Rhodocyclales 206389|Rhodocyclales L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA - - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C k59_561936_1 420662.Mpe_A3415 4.82e-41 155.0 COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,2VI8I@28216|Betaproteobacteria,1KJ94@119065|unclassified Burkholderiales 28216|Betaproteobacteria CO Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps dsbD - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - DsbC,DsbD,Thioredoxin_2,Thioredoxin_7 k59_1159619_1 795666.MW7_0611 2.05e-63 200.0 2ANPA@1|root,31DNS@2|Bacteria,1RHTE@1224|Proteobacteria,2VRS4@28216|Betaproteobacteria,1K9XX@119060|Burkholderiaceae 28216|Betaproteobacteria M Protein of unknown function (DUF3833) - - - - - - - - - - - - DUF3833 k59_263641_1 1347368.HG964403_gene4657 8.15e-16 78.2 COG0331@1|root,COG0331@2|Bacteria,1TPB7@1239|Firmicutes,4HBCU@91061|Bacilli,1ZBGQ@1386|Bacillus 91061|Bacilli I malonyl CoA-acyl carrier protein transacylase fabD - 2.3.1.39 ko:K00645 ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 M00082 R01626,R11671 RC00004,RC00039,RC02727 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyl_transf_1 k59_263641_2 247633.GP2143_06494 7.69e-16 77.0 COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,1RMDE@1236|Gammaproteobacteria,1J5M1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP fabF GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0033817,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - iAF1260.b1095,iAPECO1_1312.APECO1_176,iB21_1397.B21_01099,iBWG_1329.BWG_0943,iE2348C_1286.E2348C_1187,iEC042_1314.EC042_1165,iEC55989_1330.EC55989_1207,iECABU_c1320.ECABU_c13085,iECBD_1354.ECBD_2506,iECB_1328.ECB_01091,iECDH10B_1368.ECDH10B_1167,iECDH1ME8569_1439.ECDH1ME8569_1030,iECD_1391.ECD_01091,iECED1_1282.ECED1_1238,iECH74115_1262.ECH74115_1474,iECIAI1_1343.ECIAI1_1130,iECIAI39_1322.ECIAI39_2066,iECO103_1326.ECO103_1140,iECO111_1330.ECO111_1372,iECO26_1355.ECO26_1428,iECOK1_1307.ECOK1_1202,iECP_1309.ECP_1087,iECS88_1305.ECS88_1109,iECSE_1348.ECSE_1159,iECSF_1327.ECSF_0994,iECSP_1301.ECSP_1396,iECUMN_1333.ECUMN_1270,iECW_1372.ECW_m1203,iECs_1301.ECs1473,iEKO11_1354.EKO11_2739,iETEC_1333.ETEC_1160,iEcDH1_1363.EcDH1_2552,iEcE24377_1341.EcE24377A_1216,iEcSMS35_1347.EcSMS35_2032,iG2583_1286.G2583_1355,iJO1366.b1095,iJR904.b1095,iLF82_1304.LF82_0607,iNRG857_1313.NRG857_05280,iSF_1195.SF1099,iSFxv_1172.SFxv_1251,iS_1188.S1179,iUMN146_1321.UM146_11850,iWFL_1372.ECW_m1203,iY75_1357.Y75_RS05720,iZ_1308.Z1734,ic_1306.c1365 Ketoacyl-synt_C,ketoacyl-synt k59_1076413_1 1231391.AMZF01000076_gene3404 8.23e-26 98.2 COG2963@1|root,COG2963@2|Bacteria,1MZ3D@1224|Proteobacteria,2VXF9@28216|Betaproteobacteria 28216|Betaproteobacteria L Transposase - - - - - - - - - - - - HTH_Tnp_1 k59_1076413_2 1121377.KB906417_gene3861 0.00026 46.2 COG2801@1|root,COG2801@2|Bacteria 2|Bacteria L transposition - - - - - - - - - - - - HTH_21,rve,rve_3 k59_179281_3 391624.OIHEL45_11093 2.54e-07 53.9 COG1225@1|root,COG1225@2|Bacteria,1RA5K@1224|Proteobacteria,2U6EF@28211|Alphaproteobacteria 28211|Alphaproteobacteria O alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - - - - - - - - - - AhpC-TSA,Redoxin k59_1159667_1 1269813.ATUL01000020_gene335 1.33e-22 98.6 COG1292@1|root,COG1292@2|Bacteria,1MV0K@1224|Proteobacteria,1RP3E@1236|Gammaproteobacteria,1WWC6@135613|Chromatiales 135613|Chromatiales M Belongs to the BCCT transporter (TC 2.A.15) family - - - ko:K03451 - - - - ko00000 2.A.15 - - BCCT k59_1159667_2 314287.GB2207_00075 3.31e-33 127.0 COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,1RU5N@1236|Gammaproteobacteria 1236|Gammaproteobacteria K COG0457 FOG TPR repeat - - - - - - - - - - - - Sulfotransfer_3,TPR_16,TPR_19,TPR_6,TPR_8 k59_561983_1 1288494.EBAPG3_27080 3.81e-129 380.0 COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,2VHNC@28216|Betaproteobacteria,372JY@32003|Nitrosomonadales 28216|Betaproteobacteria H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA - 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,GlutR_dimer,Shikimate_DH k59_989171_1 1286631.X805_38880 7.33e-49 168.0 COG1364@1|root,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,2VJ84@28216|Betaproteobacteria,1KJ4N@119065|unclassified Burkholderiales 28216|Betaproteobacteria E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate argJ - 2.3.1.1,2.3.1.35 ko:K00620 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259,R02282 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - ArgJ k59_989171_2 998088.B565_0352 4.37e-09 58.5 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,1RM9M@1236|Gammaproteobacteria,1Y460@135624|Aeromonadales 135624|Aeromonadales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_1159709_2 292.DM42_6392 3.3e-53 180.0 COG1804@1|root,COG1804@2|Bacteria,1MU4A@1224|Proteobacteria,2VKDA@28216|Betaproteobacteria,1JZU6@119060|Burkholderiaceae 28216|Betaproteobacteria C L-carnitine dehydratase bile acid-inducible protein F - - 2.8.3.22 ko:K18289 ko00660,map00660 - R02407,R03154 RC00014 ko00000,ko00001,ko01000 - - - CoA_transf_3 k59_309322_1 1408444.JHYC01000001_gene1264 2.22e-98 298.0 COG2224@1|root,COG2224@2|Bacteria,1MWIF@1224|Proteobacteria,1RQAK@1236|Gammaproteobacteria,1JDF8@118969|Legionellales 118969|Legionellales C Phosphoenolpyruvate phosphomutase - - - - - - - - - - - - ICL k59_1159760_1 258052.JNYV01000008_gene3529 5.51e-58 189.0 COG0494@1|root,COG0494@2|Bacteria,2II41@201174|Actinobacteria 201174|Actinobacteria L Belongs to the Nudix hydrolase family - - - - - - - - - - - - NUDIX k59_1159760_2 62928.azo1686 7.87e-14 72.0 COG0697@1|root,COG0697@2|Bacteria,1MWSU@1224|Proteobacteria,2VHP3@28216|Betaproteobacteria,2KUCN@206389|Rhodocyclales 206389|Rhodocyclales EG Solute carrier family 35 - - - - - - - - - - - - EamA k59_562067_1 640081.Dsui_3446 1.12e-59 195.0 COG0382@1|root,COG0382@2|Bacteria,1MXCM@1224|Proteobacteria,2VKY4@28216|Betaproteobacteria,2KX0U@206389|Rhodocyclales 206389|Rhodocyclales H UbiA prenyltransferase family - - - - - - - - - - - - UbiA k59_520415_1 457398.HMPREF0326_02184 2.5e-45 150.0 COG1786@1|root,COG1786@2|Bacteria,1RFUH@1224|Proteobacteria,436PF@68525|delta/epsilon subdivisions,2X1BE@28221|Deltaproteobacteria,2MEPW@213115|Desulfovibrionales 28221|Deltaproteobacteria S Protein of unknown function DUF126 - - - - - - - - - - - - DUF126 k59_179403_1 318167.Sfri_0055 3.43e-21 94.7 COG3381@1|root,COG3381@2|Bacteria,1MWWM@1224|Proteobacteria,1S449@1236|Gammaproteobacteria,2Q9C3@267890|Shewanellaceae 1236|Gammaproteobacteria S PFAM cytoplasmic chaperone TorD family protein - - - - - - - - - - - - Nitrate_red_del k59_607714_1 1502851.FG93_01066 6.12e-65 216.0 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,3JR8W@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Adenylate cyclase - - - - - - - - - - - - TPR_16 k59_53226_2 864051.BurJ1DRAFT_0536 1.77e-13 69.7 COG3005@1|root,COG3005@2|Bacteria,1MWV2@1224|Proteobacteria,2VMSB@28216|Betaproteobacteria,1KPBQ@119065|unclassified Burkholderiales 28216|Betaproteobacteria C PFAM NapC NirT cytochrome c - - - ko:K02569 - - - - ko00000 - - - Cytochrom_NNT k59_1331761_1 1380394.JADL01000009_gene3410 5.64e-67 213.0 COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,2TVPQ@28211|Alphaproteobacteria,2JVIG@204441|Rhodospirillales 204441|Rhodospirillales C Zinc-binding dehydrogenase - - - - - - - - - - - - ADH_N,ADH_zinc_N k59_10735_1 1116472.MGMO_157c00090 2.83e-41 155.0 COG2010@1|root,COG4885@1|root,COG2010@2|Bacteria,COG4885@2|Bacteria,1R65B@1224|Proteobacteria,1RWBY@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Cytochrome c554 and c-prime - - - - - - - - - - - - Cytochrome_C554,Cytochrome_CBB3 k59_860302_1 1380394.JADL01000003_gene4747 1.31e-17 87.8 COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,2TRSN@28211|Alphaproteobacteria,2JR0Z@204441|Rhodospirillales 204441|Rhodospirillales M AsmA family - - - ko:K07289 - - - - ko00000 - - - AsmA k59_1115975_1 113395.AXAI01000017_gene4684 4.24e-23 98.6 COG2207@1|root,COG2207@2|Bacteria,1MUV5@1224|Proteobacteria,2TS27@28211|Alphaproteobacteria,3JQSG@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - AraC_binding,Cupin_2,HTH_18 k59_989272_1 1121033.AUCF01000021_gene2873 3.17e-31 123.0 COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,2TTE8@28211|Alphaproteobacteria,2JP8X@204441|Rhodospirillales 204441|Rhodospirillales M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) murD - 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - IlvN,Mur_ligase_C,Mur_ligase_M k59_989272_2 631454.N177_4009 2.23e-08 54.3 2C7F6@1|root,2Z8AK@2|Bacteria,1PEE5@1224|Proteobacteria,2TTH2@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_946624_2 1131553.JIBI01000030_gene2450 4e-43 152.0 COG0212@1|root,COG0212@2|Bacteria,1MZG0@1224|Proteobacteria,2VJZE@28216|Betaproteobacteria,372VK@32003|Nitrosomonadales 28216|Betaproteobacteria H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family fthC - 6.3.3.2 ko:K01934 ko00670,ko01100,map00670,map01100 - R02301 RC00183 ko00000,ko00001,ko01000 - - - 5-FTHF_cyc-lig k59_946624_3 1007105.PT7_3561 5.19e-82 248.0 COG1633@1|root,COG1633@2|Bacteria,1R5K9@1224|Proteobacteria,2WA07@28216|Betaproteobacteria,3T5W9@506|Alcaligenaceae 28216|Betaproteobacteria S Ferritin-like domain - - - - - - - - - - - - Ferritin_2 k59_946624_4 543728.Vapar_6380 3.1e-31 116.0 COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,2VR5K@28216|Betaproteobacteria,4ABQH@80864|Comamonadaceae 28216|Betaproteobacteria K Sigma-70, region 4 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_733503_1 526225.Gobs_2383 9.22e-08 61.2 COG2267@1|root,COG2267@2|Bacteria,2I0NW@201174|Actinobacteria,4EVDX@85013|Frankiales 201174|Actinobacteria I TAP-like protein - - 3.1.1.76 ko:K22250 - - - - ko00000,ko01000 - - - Abhydrolase_1 k59_648105_1 1223521.BBJX01000008_gene1395 1.11e-147 443.0 COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,2VKDZ@28216|Betaproteobacteria,4A9W6@80864|Comamonadaceae 28216|Betaproteobacteria C aconitate hydratase acnA - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_309438_1 1286093.C266_11555 3.79e-217 616.0 COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,2VHFD@28216|Betaproteobacteria,1JZSF@119060|Burkholderiaceae 28216|Betaproteobacteria J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS - 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD k59_309438_2 446466.Cfla_1624 0.000587 42.0 COG0290@1|root,COG0290@2|Bacteria,2GJGT@201174|Actinobacteria,4F0YP@85016|Cellulomonadaceae 201174|Actinobacteria J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins infC GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008 - ko:K02520 - - - - ko00000,ko03012,ko03029 - - - IF3_C,IF3_N k59_392236_1 1158146.KB907126_gene1657 2.34e-21 94.4 COG1943@1|root,COG1943@2|Bacteria,1R75U@1224|Proteobacteria,1S1SP@1236|Gammaproteobacteria,1WXZQ@135613|Chromatiales 135613|Chromatiales L Transposase IS200 like - - - ko:K07491 - - - - ko00000 - - - Y1_Tnp k59_10805_2 1028800.RG540_CH13830 1.04e-29 119.0 2DUXE@1|root,312CE@2|Bacteria,1PQIE@1224|Proteobacteria,2V2XC@28211|Alphaproteobacteria,4BJT8@82115|Rhizobiaceae 28211|Alphaproteobacteria S Phage T7 capsid assembly protein - - - - - - - - - - - - Phage_T7_Capsid k59_10805_3 1096930.L284_17145 2.67e-66 214.0 28IR7@1|root,2Z8QR@2|Bacteria,1PBTP@1224|Proteobacteria,2U248@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_53344_1 288000.BBta_4348 6.45e-47 152.0 COG3293@1|root,COG3293@2|Bacteria,1RDFE@1224|Proteobacteria,2U7XM@28211|Alphaproteobacteria,3K6EK@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L Evidence Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - DUF4096 k59_53344_2 1530186.JQEY01000003_gene2201 3.6e-31 112.0 COG3293@1|root,COG3293@2|Bacteria,1N3B0@1224|Proteobacteria,2UC5W@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Evidence Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - DDE_Tnp_1_2 k59_309488_1 931627.MycrhDRAFT_3616 5.62e-36 135.0 COG2303@1|root,COG2303@2|Bacteria,2GUQ4@201174|Actinobacteria 201174|Actinobacteria E GMC oxidoreductase - - - - - - - - - - - - GMC_oxred_C,GMC_oxred_N k59_351473_1 1123034.JMKP01000002_gene1896 2.88e-20 89.7 COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,1RPBJ@1236|Gammaproteobacteria,3NJR4@468|Moraxellaceae 1236|Gammaproteobacteria J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome tsf GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005085,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0019899,GO:0034641,GO:0034645,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051020,GO:0065007,GO:0065009,GO:0071704,GO:0097159,GO:0098772,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02357 - - - - ko00000,ko03012,ko03029 - - - EF_TS k59_351473_2 1401065.HMPREF2130_08130 1.41e-40 140.0 COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,2VH8A@28216|Betaproteobacteria,3T1KA@506|Alcaligenaceae 28216|Betaproteobacteria F Catalyzes the reversible phosphorylation of UMP to UDP pyrH - 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 - R00158 RC00002 ko00000,ko00001,ko01000 - - - AA_kinase k59_392288_1 614083.AWQR01000011_gene2383 6.29e-68 228.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2VH0Y@28216|Betaproteobacteria,4AAB0@80864|Comamonadaceae 28216|Betaproteobacteria I 3-hydroxyacyl-CoA dehydrogenase fadB2 - 1.1.1.35,4.2.1.17,5.1.2.3 ko:K01782 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_1202538_1 671143.DAMO_0749 3.07e-134 402.0 COG1222@1|root,COG2433@1|root,COG1222@2|Bacteria,COG2433@2|Bacteria,2NQB9@2323|unclassified Bacteria 2|Bacteria O Proteasomal ATPase OB/ID domain arc GO:0000302,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0010499,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0019941,GO:0022623,GO:0022624,GO:0030163,GO:0030312,GO:0032991,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042802,GO:0043170,GO:0043335,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0044877,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070628,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097366,GO:0140030,GO:0140035,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170,GO:1902494,GO:1905368,GO:1905369 2.7.13.3 ko:K07184,ko:K07777,ko:K12065,ko:K13525,ko:K13527 ko02020,ko03050,ko04141,ko05134,map02020,map03050,map04141,map05134 M00342,M00400,M00403,M00478 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02044,ko03019,ko03051,ko04131,ko04147 3.A.16.1,3.A.7.11.1 - - AAA,Prot_ATP_ID_OB k59_648186_1 502025.Hoch_4196 3.51e-16 80.5 COG0452@1|root,COG0452@2|Bacteria,1RA60@1224|Proteobacteria 1224|Proteobacteria H PFAM flavoprotein - - 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - - Flavoprotein k59_135842_1 1163407.UU7_10351 3.97e-34 130.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,1RMUR@1236|Gammaproteobacteria,1X3I4@135614|Xanthomonadales 135614|Xanthomonadales V Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation msbA GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015399,GO:0015405,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0071702 - ko:K11085 ko02010,map02010 - - - ko00000,ko00001,ko01000,ko02000 3.A.1.106 - - ABC_membrane,ABC_tran k59_135842_2 1121035.AUCH01000003_gene1252 1.19e-41 147.0 COG1088@1|root,COG1088@2|Bacteria,1MU5E@1224|Proteobacteria,2VJAD@28216|Betaproteobacteria,2KV8P@206389|Rhodocyclales 206389|Rhodocyclales M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily rmlB - 4.2.1.46 ko:K01710 ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130 M00793 R06513 RC00402 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd k59_520580_1 365044.Pnap_0990 2.33e-56 191.0 COG1030@1|root,COG1030@2|Bacteria,1MUJN@1224|Proteobacteria,2VMUK@28216|Betaproteobacteria,4ACZ0@80864|Comamonadaceae 28216|Betaproteobacteria O NfeD-like C-terminal, partner-binding nfeD - - ko:K07403 - - - - ko00000 - - - NfeD k59_817700_1 264198.Reut_B5861 1.9e-11 64.3 COG0654@1|root,COG0654@2|Bacteria,1MWWT@1224|Proteobacteria,2VISJ@28216|Betaproteobacteria,1K1U6@119060|Burkholderiaceae 28216|Betaproteobacteria CH salicylate hydroxylase mhbM - 1.14.13.1,1.14.13.24 ko:K00480,ko:K22270 ko00362,ko00621,ko00624,ko00626,ko01100,ko01120,ko01220,map00362,map00621,map00624,map00626,map01100,map01120,map01220 - R00818,R02589,R05632,R06915,R06936,R06939 RC00046,RC00389 ko00000,ko00001,ko01000 - - - FAD_binding_3 k59_817700_2 795666.MW7_2535 4.99e-45 158.0 COG1304@1|root,COG1304@2|Bacteria,1MUEZ@1224|Proteobacteria,2VHZV@28216|Betaproteobacteria,1KGJP@119060|Burkholderiaceae 28216|Betaproteobacteria C Dehydrogenase - - 1.1.99.31 ko:K15054 ko00627,ko01120,map00627,map01120 - R04160,R07664 RC00240 ko00000,ko00001,ko01000 - - - FMN_dh k59_1245229_1 207954.MED92_01144 1.51e-07 51.6 COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,1RMNB@1236|Gammaproteobacteria,1XI4J@135619|Oceanospirillales 135619|Oceanospirillales I An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism accC - 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_1245229_2 113355.CM001775_gene1206 8.42e-26 102.0 COG0511@1|root,COG0511@2|Bacteria,1G6MY@1117|Cyanobacteria 1117|Cyanobacteria I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA accB - - ko:K02160 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742 RC00040,RC00367 ko00000,ko00001,ko00002 - - - Biotin_lipoyl k59_15099_1 1123393.KB891316_gene1945 5.67e-72 241.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,1KR9P@119069|Hydrogenophilales 28216|Betaproteobacteria V AcrB/AcrD/AcrF family acrD - - ko:K03296,ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_695281_1 713587.THITH_12030 5.91e-105 309.0 COG0437@1|root,COG0437@2|Bacteria,1NBU3@1224|Proteobacteria,1RRYZ@1236|Gammaproteobacteria,1WVZM@135613|Chromatiales 135613|Chromatiales C PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - ko:K00184 - - - - ko00000 5.A.3 - - Fer4_11,Fer4_7 k59_950877_1 1342299.Z947_4096 1.18e-39 134.0 COG1359@1|root,COG1359@2|Bacteria,1N0P9@1224|Proteobacteria,2UCIC@28211|Alphaproteobacteria,3ZXX6@60136|Sulfitobacter 28211|Alphaproteobacteria S Antibiotic biosynthesis monooxygenase - - - - - - - - - - - - ABM k59_950877_2 76114.ebA232 1.55e-121 357.0 COG1893@1|root,COG1893@2|Bacteria,1P0AW@1224|Proteobacteria,2VKYM@28216|Betaproteobacteria,2KWGC@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid apbA - 1.1.1.169 ko:K00077 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R02472 RC00726 ko00000,ko00001,ko00002,ko01000 - - - ApbA,ApbA_C k59_178676_1 1244869.H261_04817 9.36e-67 216.0 COG0683@1|root,COG0683@2|Bacteria,1MWQB@1224|Proteobacteria,2U16N@28211|Alphaproteobacteria,2JVNK@204441|Rhodospirillales 204441|Rhodospirillales E COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component - - - - - - - - - - - - Peripla_BP_6 k59_732751_1 414684.RC1_2561 9.22e-74 234.0 COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,2TR87@28211|Alphaproteobacteria,2JPNV@204441|Rhodospirillales 204441|Rhodospirillales J Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) tgt - 2.4.2.29 ko:K00773 - - R03789,R10209 RC00063 ko00000,ko01000,ko03016 - - - TGT k59_776780_1 441620.Mpop_1253 1.25e-94 290.0 COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,1PBXW@1224|Proteobacteria,2V28E@28211|Alphaproteobacteria,1JY76@119045|Methylobacteriaceae 28211|Alphaproteobacteria C Fumarate hydratase (Fumerase) - - 4.2.1.2,4.2.1.32 ko:K01676,ko:K03779 ko00020,ko00620,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00630,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374 R00339,R01082 RC00443,RC01382 ko00000,ko00001,ko00002,ko01000 - - - Fumerase k59_1115365_1 864069.MicloDRAFT_00024860 1.87e-68 224.0 COG1053@1|root,COG1053@2|Bacteria,1MURY@1224|Proteobacteria,2TSRQ@28211|Alphaproteobacteria,1JUEY@119045|Methylobacteriaceae 28211|Alphaproteobacteria C FAD dependent oxidoreductase - - - - - - - - - - - - FAD_binding_2 k59_988548_1 595537.Varpa_4906 9.66e-49 162.0 COG0861@1|root,COG0861@2|Bacteria,1MWC9@1224|Proteobacteria,2VJSY@28216|Betaproteobacteria,4AC5T@80864|Comamonadaceae 28216|Betaproteobacteria P Membrane protein TerC terC - - - - - - - - - - - CBS,CorC_HlyC,TerC k59_988548_2 639282.DEFDS_2094 2.01e-17 82.8 COG0530@1|root,COG0530@2|Bacteria,2GEW4@200930|Deferribacteres 200930|Deferribacteres P Sodium/calcium exchanger protein - - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex k59_10007_1 1121459.AQXE01000001_gene2766 1.91e-94 296.0 COG0305@1|root,COG0358@1|root,COG0305@2|Bacteria,COG0358@2|Bacteria,1PZ6S@1224|Proteobacteria,42YZ3@68525|delta/epsilon subdivisions,2WU0W@28221|Deltaproteobacteria,2MAW9@213115|Desulfovibrionales 28221|Deltaproteobacteria L Toprim-like - - - - - - - - - - - - DnaB_C,Toprim_2 k59_519754_1 1244869.H261_11314 7.67e-71 229.0 COG0665@1|root,COG0665@2|Bacteria,1MVIZ@1224|Proteobacteria,2TRT9@28211|Alphaproteobacteria,2JPUI@204441|Rhodospirillales 204441|Rhodospirillales E Oxidative deamination of D-amino acids dadA - 1.4.5.1 ko:K00285 ko00360,map00360 - R01374,R09493 RC00006,RC00025 ko00000,ko00001,ko01000 - - - DAO k59_434522_1 909663.KI867150_gene333 6.72e-66 220.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,42MMV@68525|delta/epsilon subdivisions,2WIZ4@28221|Deltaproteobacteria,2MQB9@213462|Syntrophobacterales 28221|Deltaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane - - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SecA_DEAD,SecA_PP_bind k59_1330941_1 640081.Dsui_3325 3.49e-147 434.0 COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,2VHKD@28216|Betaproteobacteria,2KV11@206389|Rhodocyclales 206389|Rhodocyclales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD-TM1,SecD_SecF,Sec_GG k59_988588_1 1463917.JODC01000036_gene5046 0.000672 42.0 COG0304@1|root,COG1028@1|root,COG3321@1|root,COG0304@2|Bacteria,COG1028@2|Bacteria,COG3321@2|Bacteria,2I9MP@201174|Actinobacteria 201174|Actinobacteria IQ Belongs to the beta-ketoacyl-ACP synthases family - - - - - - - - - - - - KAsynt_C_assoc,KR,Ketoacyl-synt_C,PS-DH,adh_short_C2,ketoacyl-synt k59_988588_2 1038860.AXAP01000197_gene2220 3.97e-63 196.0 COG0251@1|root,COG0251@2|Bacteria,1RAKQ@1224|Proteobacteria,2U5F4@28211|Alphaproteobacteria,3K1NP@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria J Endoribonuclease L-PSP - - - - - - - - - - - - Ribonuc_L-PSP k59_308595_1 395493.BegalDRAFT_3005 3.7e-30 112.0 COG2802@1|root,COG2802@2|Bacteria,1RFYH@1224|Proteobacteria,1S54H@1236|Gammaproteobacteria,462T3@72273|Thiotrichales 72273|Thiotrichales S ATP-dependent protease La (LON) substrate-binding domain - - - ko:K07157 - - - - ko00000 - - - LON_substr_bdg k59_308595_2 740709.A10D4_00065 7.31e-09 58.5 COG0773@1|root,COG0773@2|Bacteria,1MUC5@1224|Proteobacteria,1RMMT@1236|Gammaproteobacteria,2QFBF@267893|Idiomarinaceae 1236|Gammaproteobacteria M Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate mpl GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0016874,GO:0016879,GO:0016881,GO:0042802,GO:0044424,GO:0044464 6.3.2.45 ko:K02558 - - - - ko00000,ko01000 - - iSDY_1059.SDY_4251 Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_1201770_1 323848.Nmul_A0807 3.27e-118 351.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VJ9G@28216|Betaproteobacteria,37267@32003|Nitrosomonadales 28216|Betaproteobacteria O Belongs to the peptidase S1C family degQ - - ko:K04691,ko:K04772 - - - - ko00000,ko01000,ko01002 - - - PDZ_2,Trypsin_2 k59_1033335_2 987059.RBXJA2T_02702 3.91e-48 166.0 COG0789@1|root,COG5012@1|root,COG0789@2|Bacteria,COG5012@2|Bacteria,1R2NF@1224|Proteobacteria,2VJDG@28216|Betaproteobacteria,1KJT9@119065|unclassified Burkholderiales 28216|Betaproteobacteria K B12 binding domain - - - ko:K22491 - - - - ko00000,ko03000 - - - B12-binding,B12-binding_2,MerR_1 k59_988626_1 1120983.KB894572_gene3112 4.83e-46 168.0 COG0365@1|root,COG0654@1|root,COG0365@2|Bacteria,COG0654@2|Bacteria,1MUF5@1224|Proteobacteria,2TR3P@28211|Alphaproteobacteria,1JNCA@119043|Rhodobiaceae 28211|Alphaproteobacteria I AMP-binding enzyme C-terminal domain - - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - AMP-binding,AMP-binding_C,FAD_binding_3 k59_776904_1 1500301.JQMF01000001_gene29 9.96e-18 83.2 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4B9BA@82115|Rhizobiaceae 28211|Alphaproteobacteria T Adenylate cyclase - - - - - - - - - - - - Guanylate_cyc,TPR_16,TPR_19 k59_776904_2 1041142.ATTP01000008_gene6415 4.49e-18 87.0 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4B9BA@82115|Rhizobiaceae 28211|Alphaproteobacteria T Adenylate cyclase - - - - - - - - - - - - Guanylate_cyc,TPR_16 k59_350616_1 1333998.M2A_0649 3.84e-86 260.0 COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,2TR9N@28211|Alphaproteobacteria,4BQ0P@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria U Belongs to the peptidase S26 family lepB - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 k59_817075_1 991905.SL003B_2528 4.01e-26 103.0 COG0583@1|root,COG0583@2|Bacteria,1MXR1@1224|Proteobacteria,2TRA1@28211|Alphaproteobacteria,4BQH8@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria K LysR substrate binding domain - - - ko:K13794,ko:K19338 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate k59_561587_1 1129374.AJE_08220 1.83e-07 53.9 COG0399@1|root,COG0399@2|Bacteria,1MUMJ@1224|Proteobacteria,1RSDY@1236|Gammaproteobacteria,469FZ@72275|Alteromonadaceae 1236|Gammaproteobacteria M Transposase zinc-binding domain - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_477162_1 365046.Rta_33920 8.33e-106 314.0 COG2358@1|root,COG2358@2|Bacteria,1MXW1@1224|Proteobacteria,2VH6G@28216|Betaproteobacteria,4ABRZ@80864|Comamonadaceae 28216|Betaproteobacteria S NMT1-like family - - - ko:K07080 - - - - ko00000 - - - NMT1_3 k59_391598_1 870187.Thini_2275 5.14e-65 212.0 COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,1RMQU@1236|Gammaproteobacteria,45ZST@72273|Thiotrichales 72273|Thiotrichales H MoeA N-terminal region (domain I and II) - - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MobB,MoeA_C,MoeA_N,NTP_transf_3 k59_1159224_2 1207063.P24_06666 1.35e-75 237.0 COG3970@1|root,COG3970@2|Bacteria,1MVA2@1224|Proteobacteria,2TT82@28211|Alphaproteobacteria,2JP91@204441|Rhodospirillales 204441|Rhodospirillales S COG3970 Fumarylacetoacetate (FAA) hydrolase family protein - - - - - - - - - - - - FAA_hydrolase k59_1075922_1 1089550.ATTH01000001_gene2120 2.13e-19 92.8 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,4NEP3@976|Bacteroidetes,1FIWT@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes C Pyruvate:ferredoxin oxidoreductase core domain II porA - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N k59_690380_1 94624.Bpet2044 1.08e-33 134.0 COG1167@1|root,COG1167@2|Bacteria,1MV6F@1224|Proteobacteria,2VGZY@28216|Betaproteobacteria,3T22T@506|Alcaligenaceae 28216|Betaproteobacteria K Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs - - - - - - - - - - - - Aminotran_1_2,GntR k59_1286782_1 977880.RALTA_A2890 5.97e-44 159.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,2VHUY@28216|Betaproteobacteria,1K0VQ@119060|Burkholderiaceae 28216|Betaproteobacteria E glutamate synthase gltB - 1.4.1.13,1.4.1.14,1.4.7.1 ko:K00265,ko:K00284 ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 - R00021,R00093,R00114,R00248,R10086 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_1286782_2 1123367.C666_08665 5.98e-06 48.9 COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,2VHXR@28216|Betaproteobacteria,2KURZ@206389|Rhodocyclales 206389|Rhodocyclales E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) aroB - 4.2.3.4 ko:K01735 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03083 RC00847 ko00000,ko00001,ko00002,ko01000 - - - DHQ_synthase k59_519921_1 640081.Dsui_0605 2.27e-133 386.0 COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,2VIWS@28216|Betaproteobacteria,2KU9J@206389|Rhodocyclales 206389|Rhodocyclales NU twitching motility protein - - - ko:K02670 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_263320_1 395495.Lcho_0420 6.62e-58 184.0 COG2905@1|root,COG2905@2|Bacteria,1QTTR@1224|Proteobacteria,2WGT1@28216|Betaproteobacteria,1KPCN@119065|unclassified Burkholderiales 28216|Betaproteobacteria T Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS k59_1075990_1 76114.ebA4892 1.47e-106 317.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2VHGM@28216|Betaproteobacteria,2KVQ7@206389|Rhodocyclales 206389|Rhodocyclales P Belongs to the ABC transporter superfamily - - 3.6.3.30 ko:K02010 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.10 - - ABC_tran,TOBE_2 k59_859870_2 59538.XP_005974149.1 1.94e-28 115.0 COG0458@1|root,KOG0370@2759|Eukaryota,38CAC@33154|Opisthokonta,3B9FF@33208|Metazoa,3CS9A@33213|Bilateria,4804V@7711|Chordata,490QX@7742|Vertebrata,3J7SX@40674|Mammalia 33208|Metazoa F aspartate binding Cad - 2.1.3.2,3.5.2.3,6.3.5.5 ko:K11540 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R01397,R01993,R10948,R10949 RC00002,RC00010,RC00043,RC00064,RC00632,RC02750,RC02798,RC02850,RC03314 ko00000,ko00001,ko00002,ko01000,ko01002 - - - Amidohydro_1,CPSase_L_D2,CPSase_L_D3,CPSase_sm_chain,GATase,MGS,OTCace,OTCace_N k59_777083_1 1449353.JQMQ01000005_gene3721 6.66e-49 168.0 COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria,2NH7X@228398|Streptacidiphilus 201174|Actinobacteria C CoA-transferase family III - - 2.8.3.16 ko:K07749 - - - - ko00000,ko01000 - - - CoA_transf_3 k59_777083_2 426117.M446_1050 4.48e-18 82.0 COG3971@1|root,COG3971@2|Bacteria,1RGHI@1224|Proteobacteria,2VB4S@28211|Alphaproteobacteria,1JT96@119045|Methylobacteriaceae 28211|Alphaproteobacteria Q 2-keto-4-pentenoate hydratase - - 4.1.1.77 ko:K01617 ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220 M00569 R02602,R05374 RC00751,RC02672 ko00000,ko00001,ko00002,ko01000 - - - - k59_561692_1 1279017.AQYJ01000020_gene1286 8.7e-74 232.0 COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,1RMJJ@1236|Gammaproteobacteria,465VY@72275|Alteromonadaceae 1236|Gammaproteobacteria KT Response regulator of the LytR AlgR family - - - ko:K02477 - - - - ko00000,ko02022 - - - LytTR,Response_reg k59_1286859_1 522306.CAP2UW1_3500 7.18e-61 212.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,2VHF3@28216|Betaproteobacteria,1KPMY@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_308835_1 631362.Thi970DRAFT_02764 5.27e-12 64.3 COG2863@1|root,COG2863@2|Bacteria,1N2NB@1224|Proteobacteria,1RZFP@1236|Gammaproteobacteria,1WYDI@135613|Chromatiales 135613|Chromatiales C PFAM Cytochrome c, class I - - - - - - - - - - - - Cytochrom_C k59_308835_2 28229.ND2E_3103 1.39e-19 87.0 COG3909@1|root,COG3909@2|Bacteria,1N1E5@1224|Proteobacteria,1S4BY@1236|Gammaproteobacteria,2Q7E7@267889|Colwelliaceae 1236|Gammaproteobacteria C Cytochrome C' - - - - - - - - - - - - Cytochrom_C_2 k59_308835_3 1038858.AXBA01000001_gene3538 1.33e-21 96.3 COG2010@1|root,COG2010@2|Bacteria,1MV6D@1224|Proteobacteria,2TT9U@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Cytochrome c, mono- and diheme variants - - 1.8.2.2 ko:K19713 - - - - ko00000,ko01000 - - - Cytochrom_C,Cytochrome_CBB3 k59_434762_1 247633.GP2143_05840 2.38e-101 306.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,1RNB5@1236|Gammaproteobacteria 1236|Gammaproteobacteria C acyl-CoA transferases carnitine dehydratase - - - - - - - - - - - - CoA_transf_3 k59_520033_1 1187851.A33M_4208 3.47e-83 261.0 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,2TSE2@28211|Alphaproteobacteria,3FCY5@34008|Rhodovulum 28211|Alphaproteobacteria E Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - - - - - - - - - - DHODB_Fe-S_bind,Fer4_20,Pyr_redox_2 k59_179023_1 395493.BegalDRAFT_2160 3.28e-26 111.0 COG1721@1|root,COG1721@2|Bacteria,1MXDI@1224|Proteobacteria,1RQSS@1236|Gammaproteobacteria 1236|Gammaproteobacteria S conserved protein (some members contain a von Willebrand factor type A (vWA) domain) - - - - - - - - - - - - DUF58 k59_647682_2 209285.XP_006695454.1 1.61e-16 81.6 COG0145@1|root,KOG1737@1|root,KOG1737@2759|Eukaryota,KOG1939@2759|Eukaryota,38C8D@33154|Opisthokonta,3NU0K@4751|Fungi,3QPUZ@4890|Ascomycota,212UP@147550|Sordariomycetes,3U8PY@5139|Sordariales,3HEQY@35718|Chaetomiaceae 4751|Fungi E Hydantoinase/oxoprolinase N-terminal region - GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006518,GO:0006575,GO:0006749,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0017168,GO:0034641,GO:0042221,GO:0043603,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051186,GO:0051716,GO:0070887,GO:0071704,GO:0097237,GO:0098754,GO:1901564,GO:1990748 3.5.2.9 ko:K01469 ko00480,map00480 - R00251 RC00553 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A,Hydantoinase_B k59_1159402_1 279714.FuraDRAFT_2865 1.47e-130 387.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2VHES@28216|Betaproteobacteria,2KQID@206351|Neisseriales 206351|Neisseriales S ATP-binding cassette protein, ChvD family yjjK - 3.6.3.25 ko:K06020 - - - - ko00000,ko01000 - - - ABC_tran,ABC_tran_Xtn k59_477338_1 1163617.SCD_n02625 2.78e-48 170.0 COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,2VI6C@28216|Betaproteobacteria 28216|Betaproteobacteria H SMART Tetratricopeptide domain protein - - - - - - - - - - - - TPR_16,TPR_19,TPR_8 k59_607260_1 1217718.ALOU01000019_gene2691 3.01e-42 149.0 COG3391@1|root,COG3391@2|Bacteria,1QD5Q@1224|Proteobacteria,2VH1W@28216|Betaproteobacteria 28216|Betaproteobacteria S cytochrome d1, heme region nirF - - ko:K19345 - - - - ko00000 - - - Cytochrom_D1 k59_607260_2 292415.Tbd_0074 5.92e-40 144.0 COG1522@1|root,COG1522@2|Bacteria,1NVYY@1224|Proteobacteria,2VHP8@28216|Betaproteobacteria,1KT7B@119069|Hydrogenophilales 119069|Hydrogenophilales K COG1522 Transcriptional regulators - - - - - - - - - - - - - k59_647687_1 76114.ebA7002 2.16e-180 522.0 COG0366@1|root,COG0366@2|Bacteria,1MWBZ@1224|Proteobacteria,2VK9R@28216|Betaproteobacteria,2KYHA@206389|Rhodocyclales 206389|Rhodocyclales F Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB - - 2.4.99.16 ko:K16147 ko00500,ko01100,map00500,map01100 - R09994 - ko00000,ko00001,ko01000 - GH13 - DUF3416 k59_263449_1 1449065.JMLL01000014_gene3240 1.42e-80 249.0 COG1028@1|root,COG1028@2|Bacteria,1MX30@1224|Proteobacteria,2TR09@28211|Alphaproteobacteria,43JQK@69277|Phyllobacteriaceae 28211|Alphaproteobacteria IQ Short chain dehydrogenase - - - - - - - - - - - - adh_short_C2 k59_1336141_2 991905.SL003B_3064 1.18e-69 224.0 COG4091@1|root,COG4091@2|Bacteria,1MUZX@1224|Proteobacteria,2TRZ0@28211|Alphaproteobacteria,4BPGM@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E homoserine dehydrogenase - - 1.1.1.3 ko:K00003 ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00017,M00018 R01773,R01775 RC00087 ko00000,ko00001,ko00002,ko01000 - - - NAD_binding_3,SAF k59_1290837_1 661478.OP10G_0529 1.47e-63 205.0 COG0454@1|root,COG0454@2|Bacteria 2|Bacteria K -acetyltransferase - - 2.3.1.59 ko:K17840 - - - - br01600,ko00000,ko01000,ko01504 - - - Acetyltransf_1,Acetyltransf_10 k59_1163476_1 1122201.AUAZ01000009_gene2878 7.21e-43 160.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,464D9@72275|Alteromonadaceae 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_1336183_1 1042375.AFPL01000026_gene3693 2.89e-15 75.9 COG3203@1|root,COG3203@2|Bacteria,1MXEB@1224|Proteobacteria,1RPY8@1236|Gammaproteobacteria,4645D@72275|Alteromonadaceae 1236|Gammaproteobacteria M Protein of unknown function (DUF1302) - - - - - - - - - - - - DUF1302 k59_1336183_2 1298865.H978DRAFT_1470 7.88e-20 89.7 28H52@1|root,2Z7HQ@2|Bacteria,1MXTF@1224|Proteobacteria,1RN8H@1236|Gammaproteobacteria,464MQ@72275|Alteromonadaceae 1236|Gammaproteobacteria S Protein of unknown function (DUF1329) - - - - - - - - - - - - DUF1329 k59_395937_2 977880.RALTA_A1100 1.43e-29 109.0 COG2863@1|root,COG2863@2|Bacteria,1MZU1@1224|Proteobacteria,2VU50@28216|Betaproteobacteria,1K735@119060|Burkholderiaceae 28216|Betaproteobacteria C Cytochrome c class cytC2 - - - - - - - - - - - Cytochrom_C,Cytochrome_CBB3 k59_355850_1 381666.H16_B1911 7.26e-135 404.0 COG0480@1|root,COG0480@2|Bacteria,1MVVY@1224|Proteobacteria,2VKWB@28216|Betaproteobacteria,1K1D4@119060|Burkholderiaceae 28216|Betaproteobacteria J promotes GTP-dependent translocation of the ribosome during translation - - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU k59_612358_1 426117.M446_0609 4.7e-46 157.0 COG3386@1|root,COG3386@2|Bacteria,1MU0C@1224|Proteobacteria,2TSXG@28211|Alphaproteobacteria,1JU78@119045|Methylobacteriaceae 28211|Alphaproteobacteria G PFAM SMP-30 Gluconolaconase LRE domain protein - - 3.1.1.17 ko:K01053,ko:K14274 ko00030,ko00040,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00040,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220 M00129 R01519,R02427,R02933,R03751 RC00537,RC00713,RC00983 ko00000,ko00001,ko00002,ko01000,ko04147 - - - SGL k59_612358_2 1121935.AQXX01000144_gene4439 6.86e-27 102.0 COG0695@1|root,COG0695@2|Bacteria,1N12W@1224|Proteobacteria,1SB6J@1236|Gammaproteobacteria,1XQX0@135619|Oceanospirillales 135619|Oceanospirillales O Domain of unknown function (DUF4124) - - - - - - - - - - - - DUF4124,Glutaredoxin k59_565342_1 1117943.SFHH103_02822 1.43e-45 157.0 COG3588@1|root,COG3588@2|Bacteria,1MVFK@1224|Proteobacteria,2TSIV@28211|Alphaproteobacteria,4B90E@82115|Rhizobiaceae 28211|Alphaproteobacteria G Belongs to the class I fructose-bisphosphate aldolase family fbaB - 4.1.2.13 ko:K01623 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000,ko03036,ko04131,ko04147 - - - Glycolytic k59_565342_2 667632.KB890173_gene3895 7.76e-116 340.0 COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,2VGZK@28216|Betaproteobacteria,1K26Y@119060|Burkholderiaceae 28216|Betaproteobacteria F phosphoribosylaminoimidazolesuccinocarboxamide synthase purC GO:0003674,GO:0003824,GO:0004639,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 ko:K01923 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04591 RC00064,RC00162 ko00000,ko00001,ko00002,ko01000 - - - SAICAR_synt k59_820719_1 454957.IA64_11635 4.01e-19 87.0 COG1266@1|root,COG1266@2|Bacteria,1QA7M@1224|Proteobacteria,1TDXU@1236|Gammaproteobacteria,1XB5M@135614|Xanthomonadales 135614|Xanthomonadales S CAAX protease self-immunity - - - ko:K07052 - - - - ko00000 - - - Abi k59_138993_1 94624.Bpet4875 4.75e-57 191.0 COG0111@1|root,COG0111@2|Bacteria,1MW1U@1224|Proteobacteria,2VIH8@28216|Betaproteobacteria,3T6F6@506|Alcaligenaceae 28216|Betaproteobacteria EH Dehydrogenase - - 1.1.1.79,1.1.1.81 ko:K12972 ko00260,ko00620,ko00630,ko01100,ko01110,ko01120,map00260,map00620,map00630,map01100,map01110,map01120 - R00465,R01388,R01392,R02527 RC00031,RC00042,RC00670 ko00000,ko00001,ko01000 - - - 2-Hacid_dh_C k59_950327_1 1439940.BAY1663_05049 1.01e-63 203.0 COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,1RNC8@1236|Gammaproteobacteria 1236|Gammaproteobacteria S oligopeptide transporter oliA GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0008150,GO:0016020,GO:0022857,GO:0051179,GO:0051234,GO:0055085 - - - - - - - - - - OPT k59_820757_1 530564.Psta_2935 1.32e-52 181.0 COG1290@1|root,COG1290@2|Bacteria,2IYI0@203682|Planctomycetes 203682|Planctomycetes C Cytochrome b(C-terminal)/b6/petD - - - - - - - - - - - - Cytochrom_B_C k59_183146_2 1168067.JAGP01000001_gene561 7.78e-29 111.0 COG1225@1|root,COG1225@2|Bacteria,1RH4P@1224|Proteobacteria,1SBKN@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Redoxin - - 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA k59_481542_1 478801.Ksed_25420 1.19e-15 82.0 COG0494@1|root,COG0494@2|Bacteria,2GN6D@201174|Actinobacteria,1ZW2P@145357|Dermacoccaceae 201174|Actinobacteria L NUDIX domain - - - - - - - - - - - - NUDIX k59_1203935_1 1187851.A33M_4208 2.88e-138 405.0 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,2TSE2@28211|Alphaproteobacteria,3FCY5@34008|Rhodovulum 28211|Alphaproteobacteria E Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - - - - - - - - - - DHODB_Fe-S_bind,Fer4_20,Pyr_redox_2 k59_1333588_1 543728.Vapar_6148 7.47e-72 230.0 COG2079@1|root,COG2079@2|Bacteria,1NECN@1224|Proteobacteria,2VNJN@28216|Betaproteobacteria,4ACBA@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM MmgE PrpD family protein - - - - - - - - - - - - MmgE_PrpD k59_223382_1 1282356.H045_01825 7.01e-61 200.0 COG0625@1|root,COG0625@2|Bacteria,1P71B@1224|Proteobacteria,1RQZH@1236|Gammaproteobacteria,1YMX7@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria O Glutathione S-transferase - - - - - - - - - - - - GST_C_2,GST_N_3 k59_223382_2 1397666.RS24_01481 3.32e-08 53.9 COG0604@1|root,COG0604@2|Bacteria,1MWRK@1224|Proteobacteria,2TQMF@28211|Alphaproteobacteria,4BPZE@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria C Zinc-binding dehydrogenase - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_948144_1 1185766.DL1_21075 1.08e-107 319.0 COG0435@1|root,COG0435@2|Bacteria,1MV50@1224|Proteobacteria,2TRDE@28211|Alphaproteobacteria,2XNV9@285107|Thioclava 28211|Alphaproteobacteria O Glutathione S-transferase, C-terminal domain yqjG GO:0003674,GO:0003824,GO:0004364,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0016491,GO:0016667,GO:0016672,GO:0016740,GO:0016765,GO:0042221,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.8.5.7 ko:K07393 - - - - ko00000,ko01000 - - - GST_C_2,GST_N_2 k59_1246642_1 1120999.JONM01000014_gene2826 3.62e-62 198.0 2C8XG@1|root,2Z7PK@2|Bacteria,1RA5I@1224|Proteobacteria,2VQGY@28216|Betaproteobacteria 28216|Betaproteobacteria S Protein of unknown function (DUF4197) - - - - - - - - - - - - DUF4197 k59_1333608_1 285535.JOEY01000049_gene1405 8.31e-20 95.1 COG1506@1|root,COG1506@2|Bacteria,2H90U@201174|Actinobacteria 201174|Actinobacteria E Tannase and feruloyl esterase - - - - - - - - - - - - Tannase k59_1078533_2 1402135.SUH3_16965 3.7e-19 87.8 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TR2Z@28211|Alphaproteobacteria,3ZWR8@60136|Sulfitobacter 28211|Alphaproteobacteria C FAD linked oxidases, C-terminal domain dld GO:0003674,GO:0003824,GO:0004457,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008720,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0034641,GO:0034654,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046034,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.1.1.303,1.1.1.4,1.1.2.4 ko:K00004,ko:K00102 ko00620,ko00650,map00620,map00650 - R00197,R02855,R02946,R10504 RC00044,RC00205,RC00525 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_563467_1 999541.bgla_1g03780 2.81e-19 83.2 COG0131@1|root,COG0131@2|Bacteria,1MWBS@1224|Proteobacteria,2VI59@28216|Betaproteobacteria,1K2PX@119060|Burkholderiaceae 28216|Betaproteobacteria E imidazoleglycerol-phosphate dehydratase hisB - 4.2.1.19 ko:K01693 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03457 RC00932 ko00000,ko00001,ko00002,ko01000 - - - IGPD k59_563467_2 395019.Bmul_0329 1.61e-60 198.0 COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,2VHX2@28216|Betaproteobacteria,1K1VS@119060|Burkholderiaceae 28216|Betaproteobacteria E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily hisC - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_265161_1 580332.Slit_2877 3.89e-31 121.0 COG2227@1|root,COG2227@2|Bacteria,1PFQK@1224|Proteobacteria,2W9ZI@28216|Betaproteobacteria,44WN5@713636|Nitrosomonadales 28216|Betaproteobacteria H PFAM Methyltransferase type 11 - - - - - - - - - - - - Methyltransf_23 k59_265161_2 1134474.O59_000224 6.38e-10 59.3 2CEDU@1|root,333S9@2|Bacteria,1NCM4@1224|Proteobacteria,1SDI0@1236|Gammaproteobacteria,1FHKW@10|Cellvibrio 1236|Gammaproteobacteria M Domain of unknown function (DUF4156) - - - - - - - - - - - - DUF4156 k59_311403_1 1123296.JQKE01000014_gene1916 2.95e-54 184.0 COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,2VJ5M@28216|Betaproteobacteria,2KPHW@206351|Neisseriales 206351|Neisseriales E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate proA - 1.2.1.41 ko:K00147 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 M00015 R03313 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_563521_1 244582.JQAK01000001_gene1540 2.41e-62 211.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria,47GQ6@766|Rickettsiales 766|Rickettsiales IQ AMP-binding enzyme C-terminal domain - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_393856_1 234267.Acid_6898 1.3e-95 291.0 COG3464@1|root,COG3464@2|Bacteria,3Y89T@57723|Acidobacteria 57723|Acidobacteria L Transposase - - - - - - - - - - - - DDE_Tnp_ISL3 k59_1036181_1 1380394.JADL01000001_gene2036 3.89e-29 114.0 COG0438@1|root,COG0438@2|Bacteria,1MVKK@1224|Proteobacteria,2TUFG@28211|Alphaproteobacteria,2JQVA@204441|Rhodospirillales 204441|Rhodospirillales M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_1036181_2 1380391.JIAS01000018_gene838 9.83e-73 233.0 COG4671@1|root,COG4671@2|Bacteria,1N1PQ@1224|Proteobacteria,2TSTV@28211|Alphaproteobacteria,2JRG0@204441|Rhodospirillales 204441|Rhodospirillales S Glycosyltransferase family 28 C-terminal domain - - - - - - - - - - - - Glyco_tran_28_C k59_311436_1 76114.ebA3918 3.51e-96 287.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,2VNV2@28216|Betaproteobacteria,2KUPV@206389|Rhodocyclales 206389|Rhodocyclales C Cysteine-rich domain - - - ko:K18928 - - - - ko00000 - - - CCG k59_649715_1 614083.AWQR01000010_gene1590 8.25e-50 167.0 COG0596@1|root,COG0596@2|Bacteria,1RB3Q@1224|Proteobacteria,2WEMP@28216|Betaproteobacteria,4AHBB@80864|Comamonadaceae 28216|Betaproteobacteria S alpha/beta hydrolase fold - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_1204096_2 1517681.HW45_21160 1.82e-07 52.8 COG1733@1|root,COG1733@2|Bacteria,1MZ6N@1224|Proteobacteria,1S6CZ@1236|Gammaproteobacteria,1XXNN@135623|Vibrionales 135623|Vibrionales K transcriptional regulators - - - - - - - - - - - - HxlR k59_479437_1 1177928.TH2_16326 2.97e-84 265.0 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TR1D@28211|Alphaproteobacteria,2JQSW@204441|Rhodospirillales 204441|Rhodospirillales E Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K12368 ko02010,ko02030,map02010,map02030 M00324 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_779666_1 2074.JNYD01000024_gene2855 9.55e-51 175.0 COG2072@1|root,COG2072@2|Bacteria,2GK95@201174|Actinobacteria,4DYPV@85010|Pseudonocardiales 201174|Actinobacteria P Flavin-binding monooxygenase-like - - - ko:K07222 - - - - ko00000 - - - FMO-like,Pyr_redox_3 k59_393917_1 1121447.JONL01000002_gene1819 0.000344 44.3 COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,42QZ1@68525|delta/epsilon subdivisions,2WKYF@28221|Deltaproteobacteria,2MA59@213115|Desulfovibrionales 28221|Deltaproteobacteria E PFAM Extracellular ligand-binding receptor - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_393917_2 331869.BAL199_26472 4.29e-44 150.0 COG0778@1|root,COG0778@2|Bacteria,1PG8V@1224|Proteobacteria,2U59W@28211|Alphaproteobacteria,4BQF9@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria C Nitroreductase family pnbA - - - - - - - - - - - Nitroreductase k59_1333761_2 926692.AZYG01000085_gene856 3.21e-38 140.0 COG2801@1|root,COG2801@2|Bacteria,1TU21@1239|Firmicutes,249HN@186801|Clostridia,3WA8E@53433|Halanaerobiales 186801|Clostridia L Integrase catalytic region - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve k59_1036236_1 13035.Dacsa_0143 1.96e-65 217.0 COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1G175@1117|Cyanobacteria 1117|Cyanobacteria H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate ribBA - 3.5.4.25,4.1.99.12 ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 - - iJN678.ribA DHBP_synthase,GTP_cyclohydro2 k59_436906_1 78245.Xaut_5018 1.68e-68 209.0 COG2185@1|root,COG2185@2|Bacteria,1N56M@1224|Proteobacteria,2UEAN@28211|Alphaproteobacteria 28211|Alphaproteobacteria I COG2185 Methylmalonyl-CoA mutase, C-terminal domain subunit (cobalamin-binding) - - 5.4.99.2,5.4.99.64 ko:K01849,ko:K20907 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - B12-binding k59_479454_1 1132855.KB913035_gene1770 3.45e-97 294.0 COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,2VI0E@28216|Betaproteobacteria 28216|Betaproteobacteria L PFAM Integrase catalytic - - - - - - - - - - - - HTH_38,rve k59_522149_1 485916.Dtox_1442 3.17e-34 140.0 COG3039@1|root,COG3039@2|Bacteria,1TPFS@1239|Firmicutes,24FM2@186801|Clostridia 186801|Clostridia L PFAM Transposase - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_436917_1 305700.B447_02071 6.88e-89 282.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2VIA1@28216|Betaproteobacteria,2KVJT@206389|Rhodocyclales 206389|Rhodocyclales KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance spoT - 2.7.6.5,3.1.7.2 ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_393947_1 1123060.JONP01000026_gene3470 2.08e-57 201.0 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria,2JQ9H@204441|Rhodospirillales 204441|Rhodospirillales C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - 1.2.5.3 ko:K03520 - - R11168 RC02800 ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_1036276_1 83406.HDN1F_10280 0.000305 43.5 COG0128@1|root,COG0287@1|root,COG0128@2|Bacteria,COG0287@2|Bacteria,1MWMK@1224|Proteobacteria,1RQ8U@1236|Gammaproteobacteria,1J541@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate aroA - 1.3.1.12,1.3.1.43,2.5.1.19 ko:K00210,ko:K00220,ko:K00800 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00022,M00025,M00040 R00732,R01728,R03460 RC00125,RC00350 ko00000,ko00001,ko00002,ko01000 - - - EPSP_synthase,PDH k59_1036276_2 62928.azo1069 6.27e-48 165.0 COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,2VIPQ@28216|Betaproteobacteria,2KV2R@206389|Rhodocyclales 206389|Rhodocyclales E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily hisC1 - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_393995_1 977880.RALTA_A0243 6.89e-66 207.0 COG2945@1|root,COG2945@2|Bacteria,1MUDY@1224|Proteobacteria,2VJ8M@28216|Betaproteobacteria,1K1NE@119060|Burkholderiaceae 28216|Betaproteobacteria S Alpha beta - - - ko:K07018 - - - - ko00000 - - - Hydrolase_4,Peptidase_S15 k59_1117520_1 1121106.JQKB01000047_gene3984 1.09e-110 329.0 COG0765@1|root,COG0765@2|Bacteria,1MV3I@1224|Proteobacteria,2TR9C@28211|Alphaproteobacteria,2JPI5@204441|Rhodospirillales 204441|Rhodospirillales E COG0765 ABC-type amino acid transport system, permease component - - - ko:K09971 ko02010,map02010 M00232 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3.18,3.A.1.3.7,3.A.1.3.8 - - BPD_transp_1 k59_779772_1 882083.SacmaDRAFT_4161 3.49e-17 84.0 28HEE@1|root,2Z7QU@2|Bacteria,2I1I5@201174|Actinobacteria 201174|Actinobacteria S Domain of unknown function (DUF932) - - - - - - - - - - - - DUF932 k59_394004_1 1120983.KB894576_gene3459 2.85e-24 102.0 COG2358@1|root,COG2358@2|Bacteria,1R8QD@1224|Proteobacteria,2U7M9@28211|Alphaproteobacteria 28211|Alphaproteobacteria S TRAP transporter solute receptor TAXI family protein - - - ko:K07080 - - - - ko00000 - - - NMT1_3 k59_735308_1 1001585.MDS_0049 9.56e-27 105.0 COG1126@1|root,COG1126@2|Bacteria,1MU9Q@1224|Proteobacteria,1RYPC@1236|Gammaproteobacteria,1YF7S@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria E ATPases associated with a variety of cellular activities ehuA - 3.6.3.21 ko:K02028 - M00236 - - ko00000,ko00002,ko01000,ko02000 3.A.1.3 - - ABC_tran k59_735308_2 935840.JAEQ01000006_gene2519 1.16e-68 213.0 COG0765@1|root,COG0765@2|Bacteria,1MWF0@1224|Proteobacteria,2TUMA@28211|Alphaproteobacteria,43J86@69277|Phyllobacteriaceae 28211|Alphaproteobacteria E ABC transporter permease - - - ko:K02029 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - BPD_transp_1 k59_223632_1 1340493.JNIF01000004_gene483 1.61e-82 253.0 COG3335@1|root,COG3335@2|Bacteria 2|Bacteria L DDE superfamily endonuclease - - - ko:K07494 - - - - ko00000 - - - DDE_3,HTH_23,HTH_29,HTH_32 k59_948414_1 1206731.BAGB01000166_gene766 3.1e-41 149.0 COG1960@1|root,COG1960@2|Bacteria,2GIX8@201174|Actinobacteria,4G1VG@85025|Nocardiaceae 201174|Actinobacteria I Acyl-CoA dehydrogenase, C-terminal domain - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_819118_1 713586.KB900536_gene2613 2.14e-84 273.0 COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,1RSQQ@1236|Gammaproteobacteria,1WWA4@135613|Chromatiales 135613|Chromatiales O Protein of unknown function, DUF255 - - - ko:K06888 - - - - ko00000 - - - Thioredox_DsbH k59_735336_2 706191.PANA_0256 4.25e-79 244.0 COG1974@1|root,COG1974@2|Bacteria,1MW80@1224|Proteobacteria,1RMXF@1236|Gammaproteobacteria,3VXXS@53335|Pantoea 1236|Gammaproteobacteria K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair lexA GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006282,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0009991,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031668,GO:0032774,GO:0032991,GO:0032993,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0048583,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0071704,GO:0080090,GO:0080134,GO:0080135,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001020,GO:2001141 3.4.21.88 ko:K01356 - M00729 - - ko00000,ko00002,ko01000,ko01002,ko03400 - - - LexA_DNA_bind,Peptidase_S24 k59_311656_1 35128.Thaps269113 5.71e-36 138.0 COG0339@1|root,KOG2089@2759|Eukaryota,2XF83@2836|Bacillariophyta 2836|Bacillariophyta O Peptidase family M3 - - - - - - - - - - - - Peptidase_M3 k59_1121035_2 543728.Vapar_2793 8.09e-53 176.0 COG0666@1|root,COG0666@2|Bacteria,1N952@1224|Proteobacteria,2VM00@28216|Betaproteobacteria,4ABHF@80864|Comamonadaceae 28216|Betaproteobacteria S Ankyrin repeats (3 copies) - - - ko:K06867 - - - - ko00000 - - - Ank_2,Ank_4 k59_1208384_1 1244869.H261_01552 1.53e-52 169.0 COG1622@1|root,COG1622@2|Bacteria,1NZNI@1224|Proteobacteria,2UJSY@28211|Alphaproteobacteria 28211|Alphaproteobacteria C cytochrome c oxidase (Subunit II) - - - - - - - - - - - - - k59_1208384_2 1244869.H261_01547 2.84e-22 95.9 COG0843@1|root,COG0843@2|Bacteria,1R57U@1224|Proteobacteria,2U068@28211|Alphaproteobacteria,2JWSB@204441|Rhodospirillales 204441|Rhodospirillales C Cytochrome C and Quinol oxidase polypeptide I - - - - - - - - - - - - COX1 k59_60551_1 977880.RALTA_A0785 1.97e-83 258.0 COG0451@1|root,COG0451@2|Bacteria,1MVE4@1224|Proteobacteria,2VH69@28216|Betaproteobacteria,1K2B6@119060|Burkholderiaceae 28216|Betaproteobacteria F Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose hldD - 5.1.3.20 ko:K03274 ko00540,ko01100,map00540,map01100 M00064 R05176 RC01291 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Epimerase k59_60551_2 1123487.KB892838_gene3813 1.4e-115 342.0 COG2870@1|root,COG2870@2|Bacteria,1MV3Z@1224|Proteobacteria,2VHNS@28216|Betaproteobacteria,2KV89@206389|Rhodocyclales 206389|Rhodocyclales M pfkB family carbohydrate kinase - - 2.7.1.167 ko:K21344 ko00540,map00540 M00064 R05646 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - PfkB k59_60551_3 1231391.AMZF01000054_gene1138 7.81e-17 81.3 COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,2VGZI@28216|Betaproteobacteria,3T369@506|Alcaligenaceae 28216|Betaproteobacteria M Belongs to the UDP-glucose GDP-mannose dehydrogenase family ugd - 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_1121046_1 401526.TcarDRAFT_1244 6.07e-14 68.2 COG0268@1|root,COG0268@2|Bacteria,1VEGX@1239|Firmicutes,4H5MZ@909932|Negativicutes 909932|Negativicutes J Binds directly to 16S ribosomal RNA rpsT - - ko:K02968 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S20p k59_1121046_2 1122236.KB905141_gene1672 1.82e-92 289.0 COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,2VHTQ@28216|Betaproteobacteria,2KKBE@206350|Nitrosomonadales 206350|Nitrosomonadales S Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane murJ - - ko:K03980 - - - - ko00000,ko01011,ko02000 2.A.66.4 - - MVIN k59_441085_1 1366055.S5MLQ2_9CAUD 1.59e-57 204.0 4QC8M@10239|Viruses,4QWMX@35237|dsDNA viruses no RNA stage,4QQU8@28883|Caudovirales,4QM0A@10699|Siphoviridae 10699|Siphoviridae S Protein of unknown function (DUF1073) - - - - - - - - - - - - - k59_784934_1 1454004.AW11_00424 1.52e-40 152.0 COG0643@1|root,COG0784@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,2VJSZ@28216|Betaproteobacteria 28216|Betaproteobacteria T Histidine kinase pilL - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_696919_1 323097.Nham_3278 3.56e-90 280.0 COG0477@1|root,COG2814@2|Bacteria,1MU1I@1224|Proteobacteria,2TVXT@28211|Alphaproteobacteria,3JTJC@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria EGP Major Facilitator Superfamily MA20_06150 - - ko:K03446 - M00701 - - ko00000,ko00002,ko02000 2.A.1.3 - - MFS_1 k59_98540_1 861299.J421_4121 3.07e-78 251.0 COG5276@1|root,COG5276@2|Bacteria,1ZTC3@142182|Gemmatimonadetes 142182|Gemmatimonadetes S LVIVD repeat - - - - - - - - - - - - LVIVD k59_1083921_1 1100720.ALKN01000034_gene583 2.56e-53 178.0 COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,2VH1Q@28216|Betaproteobacteria,4AA26@80864|Comamonadaceae 28216|Betaproteobacteria C aldo keto reductase - - - - - - - - - - - - Aldo_ket_red k59_316724_1 1120999.JONM01000002_gene566 1.52e-39 144.0 COG0500@1|root,COG2226@2|Bacteria,1PA5F@1224|Proteobacteria,2VJP9@28216|Betaproteobacteria,2KU4J@206351|Neisseriales 206351|Neisseriales H Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway bioC - 2.1.1.197 ko:K02169 ko00780,ko01100,map00780,map01100 M00572 R09543 RC00003,RC00460 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_11 k59_60613_1 1046627.BZARG_2471 1.72e-75 244.0 COG0591@1|root,COG0591@2|Bacteria,4NEN8@976|Bacteroidetes,1HYVB@117743|Flavobacteriia 976|Bacteroidetes E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family yidK - - - - - - - - - - - SSF k59_653963_1 652103.Rpdx1_1683 2.35e-28 112.0 COG4177@1|root,COG4177@2|Bacteria,1MUPI@1224|Proteobacteria,2TTN2@28211|Alphaproteobacteria,3JRRF@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Belongs to the binding-protein-dependent transport system permease family urtC - - ko:K11961 ko02010,map02010 M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4.4,3.A.1.4.5 - - BPD_transp_2 k59_653963_2 420324.KI912045_gene4400 4.61e-36 134.0 COG0559@1|root,COG0559@2|Bacteria,1MVND@1224|Proteobacteria,2TRMA@28211|Alphaproteobacteria,1JR22@119045|Methylobacteriaceae 28211|Alphaproteobacteria P Belongs to the binding-protein-dependent transport system permease family urtB - - ko:K11960 ko02010,map02010 M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4.4,3.A.1.4.5 - - BPD_transp_2 k59_653996_1 864069.MicloDRAFT_00027090 1.59e-10 58.5 COG2963@1|root,COG2963@2|Bacteria,1RGZ5@1224|Proteobacteria,2UAIS@28211|Alphaproteobacteria,1JVU8@119045|Methylobacteriaceae 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - HTH_Tnp_1 k59_398338_1 272560.BPSL2192 2.07e-141 415.0 COG2225@1|root,COG2225@2|Bacteria,1MVEV@1224|Proteobacteria,2VJK0@28216|Betaproteobacteria,1K4T4@119060|Burkholderiaceae 28216|Betaproteobacteria H Belongs to the malate synthase family aceB - 2.3.3.9 ko:K01638 ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200 M00012 R00472 RC00004,RC00308,RC02747 ko00000,ko00001,ko00002,ko01000 - - - Malate_synthase k59_316831_1 75379.Tint_1944 6.41e-29 110.0 COG1416@1|root,COG1416@2|Bacteria,1RE8C@1224|Proteobacteria,2VV8B@28216|Betaproteobacteria 28216|Betaproteobacteria S DsrE/DsrF-like family - - - ko:K09004 - - - - ko00000 - - - DrsE k59_316831_2 1123392.AQWL01000002_gene1903 1.86e-32 119.0 COG1416@1|root,COG1416@2|Bacteria,1RE8C@1224|Proteobacteria,2VV8B@28216|Betaproteobacteria,1KT2D@119069|Hydrogenophilales 119069|Hydrogenophilales S DsrE/DsrF-like family - - - - - - - - - - - - DrsE k59_316831_3 991905.SL003B_2822 2.48e-24 97.4 COG3439@1|root,COG3439@2|Bacteria,1RHPD@1224|Proteobacteria,2U95F@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Domain of unknown function DUF302 - - - - - - - - - - - - DUF302 k59_227764_1 1042377.AFPJ01000008_gene2023 6.02e-56 187.0 COG1804@1|root,COG1804@2|Bacteria,1MW1H@1224|Proteobacteria,1RN9B@1236|Gammaproteobacteria,46AB9@72275|Alteromonadaceae 1236|Gammaproteobacteria C CoA-transferase family III - - 2.8.3.16 ko:K07749 - - - - ko00000,ko01000 - - - CoA_transf_3 k59_398392_1 864073.HFRIS_008416 7.22e-47 155.0 COG0241@1|root,COG0241@2|Bacteria,1RDGR@1224|Proteobacteria,2VQ49@28216|Betaproteobacteria,473BX@75682|Oxalobacteraceae 28216|Betaproteobacteria G Polynucleotide kinase 3 phosphatase gmhB GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0034200,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914 3.1.3.82,3.1.3.83 ko:K03273 ko00540,ko01100,map00540,map01100 M00064 R05647,R09771 RC00017 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hydrolase,Hydrolase_like,PNK3P k59_398392_2 445973.CLOBAR_02710 2.67e-12 72.0 COG0751@1|root,COG0751@2|Bacteria,1TNZ7@1239|Firmicutes,248RS@186801|Clostridia,25R5C@186804|Peptostreptococcaceae 186801|Clostridia J Glycyl-tRNA synthetase beta subunit glyS - 6.1.1.14 ko:K01879 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_1,tRNA_synt_2f k59_269108_1 1342301.JASD01000008_gene2522 6.88e-26 109.0 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria 28211|Alphaproteobacteria G COG1593 TRAP-type C4-dicarboxylate transport system large permease component - - - ko:K11690 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.56.1 - - DctM k59_697065_1 323848.Nmul_A1271 7.97e-106 325.0 COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,2VIM4@28216|Betaproteobacteria,371XJ@32003|Nitrosomonadales 28216|Betaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC - - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH,HHH_2,HHH_5,UVR,UvrC_HhH_N k59_60770_1 1198452.Jab_2c00030 2.34e-73 248.0 COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,2VHRU@28216|Betaproteobacteria,473K1@75682|Oxalobacteraceae 28216|Betaproteobacteria Q Linear gramicidin synthase subunit - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase k59_1041699_1 1123499.KB908027_gene1897 2.22e-67 211.0 COG2941@1|root,COG2941@2|Bacteria,1RAA1@1224|Proteobacteria,2VQRE@28216|Betaproteobacteria,2KPV8@206351|Neisseriales 206351|Neisseriales H Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol coq7 - - ko:K06134 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00128 R04984,R08775 RC01254 ko00000,ko00001,ko00002,ko01000 - - - COQ7 k59_1041699_2 757424.Hsero_3851 2.86e-47 155.0 COG1765@1|root,COG1765@2|Bacteria,1RCZW@1224|Proteobacteria,2VR62@28216|Betaproteobacteria,4736Y@75682|Oxalobacteraceae 28216|Betaproteobacteria O regulator of disulfide bond formation yhfA - - ko:K07397 - - - - ko00000 - - - OsmC k59_1121191_1 580332.Slit_1441 2.14e-14 73.2 COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,2VHU7@28216|Betaproteobacteria,44W5Q@713636|Nitrosomonadales 28216|Betaproteobacteria NU PFAM type II secretion system protein E pilT2 - - ko:K02670 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_1121191_2 1263831.F543_19350 1.34e-69 218.0 COG2171@1|root,COG2171@2|Bacteria,1MU0Y@1224|Proteobacteria,1RPCS@1236|Gammaproteobacteria,1Y6YY@135625|Pasteurellales 135625|Pasteurellales E Belongs to the transferase hexapeptide repeat family dapD - 2.3.1.117 ko:K00674 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R04365 RC00004,RC01136 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,Hexapep_2,THDPS_N_2 k59_441287_1 518766.Rmar_2818 1.52e-35 140.0 2DBB2@1|root,2Z858@2|Bacteria,4P25P@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - k59_526620_1 640512.BC1003_0664 1.53e-94 291.0 COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2VZNG@28216|Betaproteobacteria,1K6IW@119060|Burkholderiaceae 28216|Betaproteobacteria L similarity to GP 3192745 - - - - - - - - - - - - DDE_Tnp_1_6,DUF772 k59_316987_1 1288494.EBAPG3_810 2.82e-63 203.0 COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,2VHSG@28216|Betaproteobacteria,3722G@32003|Nitrosomonadales 28216|Betaproteobacteria J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome tsf - - ko:K02357 - - - - ko00000,ko03012,ko03029 - - - EF_TS k59_1084186_1 1123367.C666_01935 3.12e-78 248.0 COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,2VHN5@28216|Betaproteobacteria,2KV4V@206389|Rhodocyclales 206389|Rhodocyclales G Belongs to the pyruvate kinase family pykA - 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PK,PK_C k59_660471_2 999141.GME_18775 8.82e-41 147.0 COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,1RP84@1236|Gammaproteobacteria,1XI7V@135619|Oceanospirillales 135619|Oceanospirillales G Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP ppnK - 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 - R00104 RC00002,RC00078 ko00000,ko00001,ko01000 - - - NAD_kinase k59_104563_2 234267.Acid_1673 1.69e-24 102.0 COG0332@1|root,COG0332@2|Bacteria,3Y83G@57723|Acidobacteria 57723|Acidobacteria H PFAM 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III - - - - - - - - - - - - ACP_syn_III_C k59_323831_1 1454004.AW11_01212 9.94e-08 55.8 COG1653@1|root,COG1653@2|Bacteria,1MVMW@1224|Proteobacteria,2VH0F@28216|Betaproteobacteria 28216|Betaproteobacteria G Extracellular solute-binding protein ugpB - - ko:K02027,ko:K05813 ko02010,map02010 M00198,M00207 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.3 - - SBP_bac_8 k59_323831_2 398578.Daci_5466 1.59e-47 161.0 COG1175@1|root,COG1175@2|Bacteria,1MVAP@1224|Proteobacteria,2VH0I@28216|Betaproteobacteria,4ACEG@80864|Comamonadaceae 28216|Betaproteobacteria P PFAM binding-protein-dependent transport systems inner membrane component ugpA - - ko:K05814 ko02010,map02010 M00198 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.3 - - BPD_transp_1 k59_1347292_1 1196324.A374_00849 1.77e-48 169.0 COG0183@1|root,COG0183@2|Bacteria,1TP07@1239|Firmicutes,4H9RJ@91061|Bacilli 91061|Bacilli I Belongs to the thiolase family atoB - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_703711_1 395963.Bind_0283 7.53e-60 193.0 COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,2TTPH@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q Dienelactone hydrolase MA20_23640 - 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 - R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 - - - DLH k59_447902_1 698761.RTCIAT899_CH14505 2.1e-118 345.0 COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1P76X@1224|Proteobacteria,2U16U@28211|Alphaproteobacteria,4BC2J@82115|Rhizobiaceae 28211|Alphaproteobacteria L Transposase and inactivated - - - ko:K07494 - - - - ko00000 - - - DDE_3 k59_660540_1 640081.Dsui_1257 8.36e-105 340.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,2VH3F@28216|Betaproteobacteria,2KUJ2@206389|Rhodocyclales 206389|Rhodocyclales L DNA polymerase III alpha subunit - - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_623157_1 113395.AXAI01000011_gene6491 6.97e-124 360.0 28IMV@1|root,2Z8NA@2|Bacteria,1R5B6@1224|Proteobacteria,2TRB5@28211|Alphaproteobacteria,3JS02@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Metal dependent phosphohydrolases with conserved 'HD' motif. - - - - - - - - - - - - - k59_1347308_1 596153.Alide_3610 2.57e-12 66.6 COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,2VM89@28216|Betaproteobacteria,4AHA1@80864|Comamonadaceae 28216|Betaproteobacteria O Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group - - 2.5.1.141 ko:K02257 ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714 M00154 R07411 RC01786 ko00000,ko00001,ko00002,ko01000,ko01006,ko03029 - - - UbiA k59_1347308_2 1123360.thalar_02885 1.36e-26 109.0 COG0843@1|root,COG0843@2|Bacteria,1R57U@1224|Proteobacteria,2U068@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Cytochrome C and Quinol oxidase polypeptide I - - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 k59_1092082_1 1163617.SCD_n02521 5.32e-67 205.0 COG0103@1|root,COG0103@2|Bacteria,1RD4A@1224|Proteobacteria,2VR5R@28216|Betaproteobacteria 28216|Betaproteobacteria J Belongs to the universal ribosomal protein uS9 family rpsI - - ko:K02996 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S9 k59_1092082_2 1458427.BAWN01000008_gene533 4.12e-63 196.0 COG0102@1|root,COG0102@2|Bacteria,1RA11@1224|Proteobacteria,2VQ07@28216|Betaproteobacteria,4ADH4@80864|Comamonadaceae 28216|Betaproteobacteria J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly rplM - - ko:K02871 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L13 k59_68788_1 420662.Mpe_A3348 3.13e-59 206.0 COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,2VHE1@28216|Betaproteobacteria,1KJYM@119065|unclassified Burkholderiales 28216|Betaproteobacteria T Putative nucleotidyltransferase substrate binding domain - - - ko:K07182 - - - - ko00000 - - - CBS,DUF294,DUF294_C,cNMP_binding k59_871442_1 935863.AWZR01000009_gene15 2.85e-85 265.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1X3DA@135614|Xanthomonadales 135614|Xanthomonadales T Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains pilR - - ko:K02667 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - HTH_8,Response_reg,Sigma54_activat k59_746320_1 1123242.JH636434_gene5621 4.49e-76 242.0 COG0702@1|root,COG0702@2|Bacteria,2IYQV@203682|Planctomycetes 203682|Planctomycetes GM PFAM NAD-dependent epimerase dehydratase - - - - - - - - - - - - DUF2867,NAD_binding_10 k59_1049765_1 1502724.FF80_00820 4.58e-20 85.5 COG0461@1|root,COG0461@2|Bacteria,1RIC5@1224|Proteobacteria,2TUX2@28211|Alphaproteobacteria,3N6S9@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) pyrE - 2.4.2.10 ko:K00762 ko00240,ko01100,map00240,map01100 M00051 R01870 RC00611 ko00000,ko00001,ko00002,ko01000 - - - Pribosyltran k59_1049765_2 269796.Rru_A1855 1.38e-33 123.0 COG3216@1|root,COG3216@2|Bacteria,1QA1I@1224|Proteobacteria,2TS9W@28211|Alphaproteobacteria,2JT24@204441|Rhodospirillales 204441|Rhodospirillales S Uncharacterized protein conserved in bacteria (DUF2062) - - - ko:K09928 - - - - ko00000 - - - DUF2062 k59_703777_1 290397.Adeh_0135 5.31e-68 222.0 COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,42MT8@68525|delta/epsilon subdivisions,2WITI@28221|Deltaproteobacteria,2YU1G@29|Myxococcales 28221|Deltaproteobacteria F Synthesizes alpha-1,4-glucan chains using ADP-glucose glgA GO:0000271,GO:0003674,GO:0003824,GO:0004373,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0008194,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046527,GO:0055114,GO:0071704,GO:1901576 2.4.1.21 ko:K00703 ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026 M00565 R02421 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 - GT5 - Glyco_transf_5,Glycos_transf_1 k59_1126975_1 228410.NE0034 9.2e-88 269.0 COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,2VNWB@28216|Betaproteobacteria,372JZ@32003|Nitrosomonadales 28216|Betaproteobacteria E PFAM Aminotransferase, class V - - 2.6.1.44,2.6.1.45,2.6.1.51 ko:K00830 ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146 M00346,M00532 R00369,R00372,R00585,R00588 RC00006,RC00008,RC00018 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 k59_1258012_1 1298867.AUES01000003_gene1243 3.82e-32 121.0 28HGI@1|root,2Z7SC@2|Bacteria,1MWKC@1224|Proteobacteria,2TUQY@28211|Alphaproteobacteria,3JWHK@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_1258012_2 572477.Alvin_1002 5.34e-23 93.2 COG2343@1|root,COG2343@2|Bacteria,1RJ3M@1224|Proteobacteria,1RVCY@1236|Gammaproteobacteria,1WY8R@135613|Chromatiales 135613|Chromatiales S Domain of unknown function (DUF427) - - - - - - - - - - - - NTP_transf_9 k59_275172_1 1210884.HG799468_gene13802 1.11e-31 125.0 COG5267@1|root,COG5267@2|Bacteria,2IYR3@203682|Planctomycetes 203682|Planctomycetes S Protein of unknown function (DUF1800) - - - - - - - - - - - - DUF1800 k59_448013_1 1196028.ALEF01000042_gene589 3.98e-31 123.0 COG1228@1|root,COG1228@2|Bacteria,1TVY2@1239|Firmicutes,4HD0B@91061|Bacilli 91061|Bacilli Q Amidohydrolase family - - 3.5.2.7 ko:K01468 ko00340,ko01100,map00340,map01100 M00045 R02288 RC00683 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1,Amidohydro_3 k59_871503_1 1005048.CFU_4174 4.35e-46 156.0 COG0279@1|root,COG0279@2|Bacteria,1NJ8X@1224|Proteobacteria,2VN12@28216|Betaproteobacteria,472JB@75682|Oxalobacteraceae 28216|Betaproteobacteria G Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate gmhA - 5.3.1.28 ko:K03271 ko00540,ko01100,map00540,map01100 M00064 R05645,R09768,R09769 RC00434 ko00000,ko00001,ko00002,ko01000,ko01005 - - - SIS_2 k59_871503_2 640081.Dsui_0099 2.76e-57 187.0 COG2823@1|root,COG2823@2|Bacteria,1MUZ2@1224|Proteobacteria,2VQIS@28216|Betaproteobacteria,2KWEB@206389|Rhodocyclales 206389|Rhodocyclales S periplasmic or secreted lipoprotein - - - - - - - - - - - - BON k59_871503_3 62928.azo3305 1.23e-12 65.1 COG0615@1|root,COG0615@2|Bacteria,1REW3@1224|Proteobacteria,2VR6S@28216|Betaproteobacteria,2KW34@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose - - 2.7.7.70 ko:K21345 ko00540,ko01100,map00540,map01100 M00064 R05644 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_234365_1 1349767.GJA_1868 9.75e-49 168.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2VJJ6@28216|Betaproteobacteria,475R1@75682|Oxalobacteraceae 28216|Betaproteobacteria E Aminotransferase class-III - - - - - - - - - - - - Aminotran_3 k59_234365_2 296591.Bpro_2004 1.05e-28 111.0 COG2358@1|root,COG2358@2|Bacteria,1MXW1@1224|Proteobacteria,2VH6G@28216|Betaproteobacteria,4ABRZ@80864|Comamonadaceae 28216|Betaproteobacteria S NMT1-like family - - - ko:K07080 - - - - ko00000 - - - NMT1_3 k59_1215392_1 1121035.AUCH01000017_gene2315 1.48e-29 115.0 COG0566@1|root,COG0566@2|Bacteria,1R9JA@1224|Proteobacteria,2VQDG@28216|Betaproteobacteria,2KW4N@206389|Rhodocyclales 206389|Rhodocyclales J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family - - - ko:K03437 - - - - ko00000,ko03016 - - - SpoU_methylase k59_1049914_1 1313172.YM304_27660 2.81e-17 87.0 COG0433@1|root,COG0433@2|Bacteria 2|Bacteria S helicase activity - - - - - - - - - - - - DUF853,DUF87 k59_490660_1 762376.AXYL_00114 1.79e-32 128.0 COG4579@1|root,COG4579@2|Bacteria,1MVRB@1224|Proteobacteria,2VJMA@28216|Betaproteobacteria,3T1G7@506|Alcaligenaceae 28216|Betaproteobacteria F Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation aceK - 2.7.11.5 ko:K00906 - - - - ko00000,ko01000 - - - AceK k59_490660_2 204773.HEAR1689 1.73e-51 174.0 COG2224@1|root,COG2224@2|Bacteria,1MWIF@1224|Proteobacteria,2VHWS@28216|Betaproteobacteria,472G8@75682|Oxalobacteraceae 28216|Betaproteobacteria C Isocitrate lyase aceA - 4.1.3.1 ko:K01637 ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200 M00012 R00479 RC00311,RC00313 ko00000,ko00001,ko00002,ko01000 - - - ICL k59_366987_1 1123366.TH3_00555 1.17e-31 130.0 COG0633@1|root,COG2114@1|root,COG0633@2|Bacteria,COG2114@2|Bacteria,1N5XC@1224|Proteobacteria,2TRGX@28211|Alphaproteobacteria,2JR7W@204441|Rhodospirillales 204441|Rhodospirillales CT Adenylyl- / guanylyl cyclase, catalytic domain - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - Fer2,Guanylate_cyc k59_1001945_1 1380394.JADL01000009_gene3424 4.81e-115 338.0 COG0834@1|root,COG0834@2|Bacteria,1MV5D@1224|Proteobacteria,2TSRF@28211|Alphaproteobacteria,2JQ3B@204441|Rhodospirillales 204441|Rhodospirillales ET general L-amino acid-binding periplasmic protein AapJ - - - ko:K09969 ko02010,map02010 M00232 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3.18,3.A.1.3.7,3.A.1.3.8 - - SBP_bac_3 k59_793226_1 177437.HRM2_44710 3.09e-105 320.0 COG1321@1|root,COG1321@2|Bacteria,1N8WG@1224|Proteobacteria 1224|Proteobacteria K iron dependent repressor - - - - - - - - - - - - - k59_1001982_1 1122611.KB903954_gene5673 2.31e-42 159.0 COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,2GMN4@201174|Actinobacteria,4EFTG@85012|Streptosporangiales 201174|Actinobacteria GT PEP-utilising enzyme, mobile domain - - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PPDK_N k59_1050005_1 1469245.JFBG01000009_gene576 8.57e-73 232.0 COG0665@1|root,COG0665@2|Bacteria,1MU7M@1224|Proteobacteria,1RP7W@1236|Gammaproteobacteria 1236|Gammaproteobacteria E fad dependent oxidoreductase - - - - - - - - - - - - DAO k59_1092360_1 266265.Bxe_B2497 3.34e-66 221.0 COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,2VJUZ@28216|Betaproteobacteria,1K22A@119060|Burkholderiaceae 28216|Betaproteobacteria EQ 5-oxoprolinase - - 3.5.2.14 ko:K01473 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A k59_69029_2 864051.BurJ1DRAFT_4193 3.47e-18 86.3 COG3292@1|root,COG3292@2|Bacteria,1QU1S@1224|Proteobacteria,2VPDV@28216|Betaproteobacteria,1KMX9@119065|unclassified Burkholderiales 28216|Betaproteobacteria T PFAM Two component regulator propeller - - - - - - - - - - - - Reg_prop k59_1299883_1 1307759.JOMJ01000003_gene894 4.71e-62 206.0 COG0380@1|root,COG0380@2|Bacteria,1MUIY@1224|Proteobacteria,42NBU@68525|delta/epsilon subdivisions,2WJX9@28221|Deltaproteobacteria,2MA96@213115|Desulfovibrionales 28221|Deltaproteobacteria G PFAM Glycosyl transferase, family 20 otsAB - 2.4.1.15,2.4.1.347,3.1.3.12 ko:K00697,ko:K16055 ko00500,ko01100,map00500,map01100 - R02737,R02778 RC00005,RC00017,RC00049,RC02748 ko00000,ko00001,ko01000,ko01003 - GT20 - Glyco_transf_20,S6PP,Trehalose_PPase k59_147293_1 1492922.GY26_06535 1.96e-21 95.1 COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1J55N@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NT Chemotaxis protein histidine kinase cheA GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006935,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009605,GO:0009892,GO:0009893,GO:0009987,GO:0010562,GO:0010604,GO:0010605,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019220,GO:0019222,GO:0019538,GO:0023014,GO:0023052,GO:0031323,GO:0031324,GO:0031325,GO:0031399,GO:0031400,GO:0031401,GO:0032101,GO:0032268,GO:0032269,GO:0032270,GO:0032879,GO:0032991,GO:0035303,GO:0035304,GO:0035306,GO:0035307,GO:0035556,GO:0036211,GO:0040011,GO:0040012,GO:0042221,GO:0042330,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0045937,GO:0046777,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0050789,GO:0050794,GO:0050896,GO:0050920,GO:0051171,GO:0051172,GO:0051173,GO:0051174,GO:0051179,GO:0051234,GO:0051246,GO:0051247,GO:0051248,GO:0051270,GO:0051641,GO:0051649,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0098561,GO:0140096,GO:1901564,GO:1901873,GO:1901875,GO:1902021,GO:2000145 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,CheY-binding,H-kinase_dim,HATPase_c,Hpt k59_147293_2 358220.C380_09615 5.61e-19 94.7 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria,4AGAQ@80864|Comamonadaceae 28216|Betaproteobacteria NT COG0840 Methyl-accepting chemotaxis protein - - - ko:K03406,ko:K03776,ko:K05875 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal,PAS_3 k59_1092396_1 382464.ABSI01000006_gene843 2.99e-29 121.0 COG3459@1|root,COG3459@2|Bacteria,46TJJ@74201|Verrucomicrobia,2IVAZ@203494|Verrucomicrobiae 203494|Verrucomicrobiae G Glycosyltransferase 36 associated - - - - - - - - - - - - - k59_1347590_1 264198.Reut_B5065 2.71e-48 179.0 COG3850@1|root,COG3850@2|Bacteria,1MWZT@1224|Proteobacteria,2VIFM@28216|Betaproteobacteria,1K2VF@119060|Burkholderiaceae 28216|Betaproteobacteria T Histidine kinase narX - 2.7.13.3 ko:K07673 ko02020,map02020 M00471 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - GAF,GAF_2,HAMP,HATPase_c,HisKA_3,PilJ k59_1347590_2 864051.BurJ1DRAFT_3321 6.45e-29 111.0 COG2197@1|root,COG2197@2|Bacteria,1NQH7@1224|Proteobacteria,2VMXI@28216|Betaproteobacteria,1KM2G@119065|unclassified Burkholderiales 28216|Betaproteobacteria K Bacterial regulatory proteins, luxR family narL - - ko:K07684 ko02020,map02020 M00471 - - ko00000,ko00001,ko00002,ko02022 - - - GerE,Response_reg k59_828712_1 1341679.P253_00577 2.57e-26 110.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,1RNB5@1236|Gammaproteobacteria,3NJFH@468|Moraxellaceae 1236|Gammaproteobacteria C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_104927_1 1005048.CFU_2876 5.67e-45 158.0 COG3026@1|root,COG3026@2|Bacteria,1MUQ8@1224|Proteobacteria,2VMZQ@28216|Betaproteobacteria,47245@75682|Oxalobacteraceae 28216|Betaproteobacteria T negative regulator of sigma E activity rseB - - ko:K03598 - - - - ko00000,ko03021 - - - MucB_RseB,MucB_RseB_C k59_448207_1 580332.Slit_2877 7.63e-56 187.0 COG2227@1|root,COG2227@2|Bacteria,1PFQK@1224|Proteobacteria,2W9ZI@28216|Betaproteobacteria,44WN5@713636|Nitrosomonadales 28216|Betaproteobacteria H PFAM Methyltransferase type 11 - - - - - - - - - - - - Methyltransf_23 k59_917183_1 713586.KB900536_gene495 1.19e-57 187.0 COG0639@1|root,COG0639@2|Bacteria,1N106@1224|Proteobacteria,1S9QJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Serine Threonine protein pphA GO:0003674,GO:0003824,GO:0004721,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008138,GO:0008150,GO:0008152,GO:0009266,GO:0009628,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0036211,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050896,GO:0071704,GO:0140096,GO:1901564 3.1.3.16 ko:K07313 - - - - ko00000,ko01000 - - - Metallophos k59_1215587_2 1469245.JFBG01000009_gene562 1.51e-68 224.0 COG0028@1|root,COG0028@2|Bacteria,1MX6Q@1224|Proteobacteria,1RRJR@1236|Gammaproteobacteria 1236|Gammaproteobacteria EH Belongs to the TPP enzyme family mdlC - 4.1.1.7 ko:K01576 ko00627,ko01120,map00627,map01120 - R01764,R02672 RC00595 ko00000,ko00001,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_746610_1 314285.KT71_11810 1.66e-74 236.0 COG4102@1|root,COG4102@2|Bacteria,1MX4R@1224|Proteobacteria,1RR99@1236|Gammaproteobacteria,1J8TE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF1501) - - - - - - - - - - - - DUF1501 k59_746613_1 794903.OPIT5_25555 3.67e-10 63.2 COG1678@1|root,COG1678@2|Bacteria,46VUF@74201|Verrucomicrobia,3K7ZM@414999|Opitutae 414999|Opitutae K Uncharacterized ACR, COG1678 - - - ko:K07735 - - - - ko00000,ko03000 - - - DUF179 k59_1050102_1 1366050.N234_17625 6.51e-152 441.0 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2VH8M@28216|Betaproteobacteria,1K0Q5@119060|Burkholderiaceae 28216|Betaproteobacteria C PFAM FAD linked oxidase domain protein glcD - 1.1.2.4,1.1.3.15,1.1.5.12 ko:K00102,ko:K00104,ko:K03777 ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130 - R00197,R00475,R00704,R11591 RC00042,RC00044 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_104957_1 1232410.KI421425_gene1547 7.1e-21 87.0 2EQ5T@1|root,32ZV0@2|Bacteria,1NFTI@1224|Proteobacteria,433CK@68525|delta/epsilon subdivisions,2WXC2@28221|Deltaproteobacteria,43VWA@69541|Desulfuromonadales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_573709_1 1121035.AUCH01000005_gene103 3.62e-47 169.0 COG4191@1|root,COG4191@2|Bacteria,1QU7R@1224|Proteobacteria,2VICU@28216|Betaproteobacteria,2KUXS@206389|Rhodocyclales 206389|Rhodocyclales T signal transduction histidine kinase pilS - 2.7.13.3 ko:K02668 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - HATPase_c,HisKA,PAS_8 k59_1092490_1 1049564.TevJSym_ah00720 8.68e-15 72.8 COG1386@1|root,COG1386@2|Bacteria,1PUA6@1224|Proteobacteria,1RNXE@1236|Gammaproteobacteria,1J5NC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves scpB - - ko:K06024 - - - - ko00000,ko03036 - - - SMC_ScpB k59_1092490_2 1469245.JFBG01000035_gene1999 1.28e-18 86.7 COG1354@1|root,COG1354@2|Bacteria,1MVCN@1224|Proteobacteria,1RNBB@1236|Gammaproteobacteria,1WW4R@135613|Chromatiales 135613|Chromatiales D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves - - - ko:K05896 - - - - ko00000,ko03036 - - - SMC_ScpA k59_533558_1 1122185.N792_03070 3.9e-64 206.0 COG0258@1|root,COG0258@2|Bacteria,1RAAR@1224|Proteobacteria,1RN1S@1236|Gammaproteobacteria,1X448@135614|Xanthomonadales 135614|Xanthomonadales L Exodeoxyribonuclease IX exo - - - - - - - - - - - 5_3_exonuc,5_3_exonuc_N k59_104988_1 666685.R2APBS1_3356 1.3e-44 155.0 COG2854@1|root,COG2854@2|Bacteria,1NKFA@1224|Proteobacteria,1RNJW@1236|Gammaproteobacteria,1X73J@135614|Xanthomonadales 135614|Xanthomonadales Q ABC-type transport system involved in resistance to organic solvents auxiliary component - - - ko:K07323 ko02010,map02010 M00210 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27.3 - - MlaC k59_192426_1 1242864.D187_003642 1.92e-24 99.0 COG1670@1|root,COG1670@2|Bacteria,1P18R@1224|Proteobacteria 2|Bacteria J Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_3 k59_192426_2 522373.Smlt0116 4.84e-13 65.5 COG3682@1|root,COG3682@2|Bacteria,1N3JW@1224|Proteobacteria,1SB84@1236|Gammaproteobacteria,1X73E@135614|Xanthomonadales 135614|Xanthomonadales K Methicillin resistance protein mecI - - - - - - - - - - - Penicillinase_R k59_1215652_1 196490.AUEZ01000007_gene5121 1.17e-06 50.4 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria,3JSZE@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - 1.2.5.3 ko:K03520 - - R11168 RC02800 ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_1215652_2 1123229.AUBC01000028_gene2289 1.69e-72 222.0 COG2080@1|root,COG2080@2|Bacteria,1RCC9@1224|Proteobacteria,2U3X8@28211|Alphaproteobacteria,3JR9Z@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C [2Fe-2S] binding domain - - 1.2.5.3 ko:K03518 - - R11168 RC02800 ko00000,ko01000 - - - Fer2,Fer2_2 k59_24065_1 1160718.SU9_03946 0.000126 46.6 COG1917@1|root,COG1917@2|Bacteria,2I4M3@201174|Actinobacteria 201174|Actinobacteria S Cupin domain - - - ko:K14673 - - - - ko00000,ko01008 - - - Cupin_2 k59_871758_1 452638.Pnec_1170 2e-116 350.0 COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,2VH5Q@28216|Betaproteobacteria,1JZV8@119060|Burkholderiaceae 28216|Betaproteobacteria EG Belongs to the IlvD Edd family ilvD - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_871758_2 987059.RBXJA2T_03868 1.14e-23 94.4 COG3803@1|root,COG3803@2|Bacteria,1RHYI@1224|Proteobacteria,2VSHT@28216|Betaproteobacteria,1KKVC@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Bacterial protein of unknown function (DUF924) - - - - - - - - - - - - DUF924 k59_24071_1 883080.HMPREF9697_01326 3.86e-53 175.0 COG1024@1|root,COG1024@2|Bacteria,1MXBB@1224|Proteobacteria,2TU4V@28211|Alphaproteobacteria,3JRS0@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I Belongs to the enoyl-CoA hydratase isomerase family - - 4.1.1.41,4.2.1.17 ko:K01692,ko:K11264 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R00923,R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00097,RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_1215668_2 243231.GSU0081 1.14e-21 87.8 2CDR8@1|root,32ZSF@2|Bacteria,1NCBG@1224|Proteobacteria,42V4S@68525|delta/epsilon subdivisions,2WSDP@28221|Deltaproteobacteria,43VIE@69541|Desulfuromonadales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_1172928_1 596154.Alide2_3621 3.09e-44 154.0 COG1211@1|root,COG1211@2|Bacteria,1MY3B@1224|Proteobacteria,2VMD6@28216|Betaproteobacteria,4ACVC@80864|Comamonadaceae 28216|Betaproteobacteria I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) ispD - 2.7.7.60,4.6.1.12 ko:K00991,ko:K12506 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05633,R05637 RC00002,RC01440 ko00000,ko00001,ko00002,ko01000 - - - IspD k59_793409_1 883080.HMPREF9697_03042 9.7e-77 241.0 COG1893@1|root,COG1893@2|Bacteria,1QMH8@1224|Proteobacteria,2TSGW@28211|Alphaproteobacteria,3JWCH@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid - - - - - - - - - - - - - k59_234726_1 1121875.KB907548_gene1622 5.22e-17 84.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,4NFW7@976|Bacteroidetes,1HZQR@117743|Flavobacteriia 976|Bacteroidetes K COGs COG5616 integral membrane protein - - - - - - - - - - - - ANAPC3,HTH_18,TPR_8 k59_704161_1 247633.GP2143_15891 4.58e-44 156.0 COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,1RQDA@1236|Gammaproteobacteria,1J5V1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T signal transduction protein with a C-terminal ATPase domain algZ - 2.7.13.3 ko:K08082 ko02020,map02020 M00493 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - His_kinase k59_69205_1 1280950.HJO_11562 1.87e-47 157.0 COG3786@1|root,COG3786@2|Bacteria,1RH22@1224|Proteobacteria,2U992@28211|Alphaproteobacteria,43XXR@69657|Hyphomonadaceae 28211|Alphaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - YkuD k59_69205_2 269796.Rru_A3634 1.91e-70 219.0 COG0325@1|root,COG0325@2|Bacteria,1MWN7@1224|Proteobacteria,2TR5Z@28211|Alphaproteobacteria,2JQKQ@204441|Rhodospirillales 204441|Rhodospirillales S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis - - - ko:K06997 - - - - ko00000 - - - Ala_racemase_N k59_192517_1 864069.MicloDRAFT_00010730 4.38e-83 257.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,1JSA1@119045|Methylobacteriaceae 28211|Alphaproteobacteria L transposase IS116 IS110 IS902 family - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_623709_1 1163617.SCD_n03010 2.37e-23 102.0 COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,2VINT@28216|Betaproteobacteria 28216|Betaproteobacteria L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA - - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,ResIII k59_1173050_1 1178482.BJB45_16870 6.33e-13 66.2 2EGR5@1|root,33AHA@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_1173050_2 1118153.MOY_03898 2.19e-09 58.5 COG2137@1|root,COG2137@2|Bacteria,1N6P6@1224|Proteobacteria,1SCMF@1236|Gammaproteobacteria,1XM17@135619|Oceanospirillales 135619|Oceanospirillales S Modulates RecA activity recX - - ko:K03565 - - - - ko00000,ko03400 - - - RecX k59_110920_1 479434.Sthe_2925 9.57e-26 110.0 COG0747@1|root,COG0747@2|Bacteria,2GA2U@200795|Chloroflexi,27YVV@189775|Thermomicrobia 189775|Thermomicrobia E Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_454239_1 627192.SLG_07580 4.09e-53 182.0 COG4638@1|root,COG4638@2|Bacteria,1MX47@1224|Proteobacteria,2TV03@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit - - - ko:K15060 ko00627,ko01120,map00627,map01120 - R09275 RC00392,RC01533 ko00000,ko00001 - - - Rieske k59_1099388_1 748247.AZKH_2569 2.63e-103 311.0 COG0330@1|root,COG0330@2|Bacteria,1MWMD@1224|Proteobacteria,2VKGC@28216|Betaproteobacteria,2KY8X@206389|Rhodocyclales 206389|Rhodocyclales O prohibitin homologues - - - - - - - - - - - - Band_7 k59_1178869_1 1112204.GPOL_c31640 7.66e-32 126.0 COG0477@1|root,COG2814@2|Bacteria,2GJK6@201174|Actinobacteria,4GA5E@85026|Gordoniaceae 201174|Actinobacteria EGP Sugar (and other) transporter bcr_1 - - ko:K07552 - - - - ko00000,ko02000 2.A.1.2 - - MFS_1 k59_1178869_2 555793.WSK_1297 2.15e-31 120.0 COG1228@1|root,COG1228@2|Bacteria,1MUYR@1224|Proteobacteria,2TSA1@28211|Alphaproteobacteria,2K2MP@204457|Sphingomonadales 204457|Sphingomonadales Q Catalyzing the hydrolysis of 4-imidazolone-5-propionate to N-formimidoyl-L-glutamate, the third step in the histidine degradation pathway hutI - 3.5.2.7 ko:K01468 ko00340,ko01100,map00340,map01100 M00045 R02288 RC00683 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1,Amidohydro_3 k59_373050_1 1122197.ATWI01000009_gene1651 7.81e-72 236.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,464P3@72275|Alteromonadaceae 1236|Gammaproteobacteria I Belongs to the enoyl-CoA hydratase isomerase family fadN - 1.1.1.35 ko:K07516 ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212 M00087 R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_1221643_1 189753.AXAS01000004_gene971 1.88e-102 307.0 COG0240@1|root,COG0240@2|Bacteria,1MXI9@1224|Proteobacteria,2TTK4@28211|Alphaproteobacteria,3JUW0@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain MA20_38170 - 1.5.1.28 ko:K04940 - - - - ko00000,ko01000 - - - ApbA,NAD_Gly3P_dh_N,Octopine_DH k59_496827_2 279714.FuraDRAFT_3516 2.92e-75 251.0 COG0404@1|root,COG0446@1|root,COG0404@2|Bacteria,COG0446@2|Bacteria,1MVEK@1224|Proteobacteria,2VK5U@28216|Betaproteobacteria,2KSCW@206351|Neisseriales 206351|Neisseriales C Belongs to the GcvT family - - 1.5.3.1 ko:K00302 ko00260,ko01100,map00260,map01100 - R00610 RC00060,RC00557 ko00000,ko00001,ko01000 - - - Fer2_4,GCV_T,GCV_T_C,Pyr_redox_2 k59_667710_1 1173025.GEI7407_3200 4.21e-43 157.0 COG1231@1|root,COG1231@2|Bacteria,1G18A@1117|Cyanobacteria,1H6YY@1150|Oscillatoriales 1117|Cyanobacteria E Monoamine oxidase - - 1.4.3.4 ko:K00274 ko00260,ko00330,ko00340,ko00350,ko00360,ko00380,ko00950,ko00982,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00260,map00330,map00340,map00350,map00360,map00380,map00950,map00982,map01100,map01110,map04726,map04728,map05030,map05031,map05034 M00135 R02173,R02382,R02529,R02532,R02613,R02908,R02919,R04025,R04300,R04674,R04890,R04893,R04894,R04907,R04908,R08346,R08347,R08348,R11354 RC00062,RC00160,RC00225,RC00676,RC00807,RC00808,RC01808,RC02226,RC02713 ko00000,ko00001,ko00002,ko01000 - - - Amino_oxidase k59_939148_1 246197.MXAN_4341 9.93e-94 296.0 COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,42M9Q@68525|delta/epsilon subdivisions,2X7DH@28221|Deltaproteobacteria,2YUKN@29|Myxococcales 28221|Deltaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - - - - - - - - - - Molybdopterin,Molydop_binding k59_171920_1 497321.C664_06648 1.38e-113 339.0 COG1875@1|root,COG1875@2|Bacteria,1MUX1@1224|Proteobacteria,2VH4P@28216|Betaproteobacteria,2KUNN@206389|Rhodocyclales 206389|Rhodocyclales T ATPase related to phosphate starvation-inducible protein PhoH - - - ko:K07175 - - - - ko00000 - - - PIN_4,PhoH k59_470283_1 1121013.P873_05690 4.99e-97 290.0 COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,1RS05@1236|Gammaproteobacteria,1X3XC@135614|Xanthomonadales 135614|Xanthomonadales S Belongs to the pirin family - - - ko:K06911 - - - - ko00000 - - - Pirin,Pirin_C k59_726054_1 1485544.JQKP01000010_gene814 3.17e-116 348.0 COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,2VIAX@28216|Betaproteobacteria,44VBV@713636|Nitrosomonadales 28216|Betaproteobacteria C TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M nuoM - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q5_N,Proton_antipo_M k59_726054_2 62928.azo1407 4.62e-22 96.7 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,2VJ2J@28216|Betaproteobacteria,2KUJW@206389|Rhodocyclales 206389|Rhodocyclales CP COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit nuoL - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M,Proton_antipo_N k59_1849_1 1499684.CCNP01000026_gene3818 3.3e-40 145.0 COG3958@1|root,COG3958@2|Bacteria,1V0K5@1239|Firmicutes,24914@186801|Clostridia,36E9P@31979|Clostridiaceae 186801|Clostridia G Transketolase tktB - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C k59_683472_1 472759.Nhal_1247 4.81e-16 85.5 COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,1RR36@1236|Gammaproteobacteria 1236|Gammaproteobacteria KLT serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - AAA_16,Guanylate_cyc,HEAT_2,PP2C_2,Pkinase k59_512957_1 882.DVU_3246 3.56e-45 164.0 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,42MRU@68525|delta/epsilon subdivisions,2WIQX@28221|Deltaproteobacteria,2MA64@213115|Desulfovibrionales 28221|Deltaproteobacteria M TIGRFAM RND efflux system, outer membrane lipoprotein, NodT - - - - - - - - - - - - OEP k59_1901_1 526218.Sterm_1193 3.02e-49 164.0 COG3568@1|root,COG3568@2|Bacteria,37BR4@32066|Fusobacteria 32066|Fusobacteria L Psort location Cytoplasmic, score 9.97 - - - - - - - - - - - - Exo_endo_phos k59_598611_1 1095769.CAHF01000022_gene41 1.34e-90 276.0 COG1024@1|root,COG1024@2|Bacteria,1MUD7@1224|Proteobacteria,2VQ37@28216|Betaproteobacteria 28216|Betaproteobacteria I Pfam Enoyl-CoA hydratase isomerase - - - ko:K13816 ko02020,ko02024,map02020,map02024 - - - ko00000,ko00001 - - - ECH_1 k59_342459_1 76114.ebA972 2.15e-46 172.0 COG3164@1|root,COG3164@2|Bacteria,1MXWF@1224|Proteobacteria,2VH52@28216|Betaproteobacteria,2KUGH@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function - - - - - - - - - - - - AsmA_2,DUF3971,DUF748 k59_86766_1 580332.Slit_2048 4.91e-121 367.0 COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,2VMQU@28216|Betaproteobacteria 28216|Betaproteobacteria T CHASE2 - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CHASE2,Guanylate_cyc k59_768749_1 1045855.DSC_02020 7.03e-09 59.7 COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,1RQM3@1236|Gammaproteobacteria,1X4AK@135614|Xanthomonadales 135614|Xanthomonadales I Cardiolipin synthase - - - - - - - - - - - - PLDc_2 k59_896615_1 365046.Rta_33920 2.7e-24 99.8 COG2358@1|root,COG2358@2|Bacteria,1MXW1@1224|Proteobacteria,2VH6G@28216|Betaproteobacteria,4ABRZ@80864|Comamonadaceae 28216|Betaproteobacteria S NMT1-like family - - - ko:K07080 - - - - ko00000 - - - NMT1_3 k59_896615_2 1007105.PT7_2623 1.59e-148 440.0 COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2VHUG@28216|Betaproteobacteria,3T6UJ@506|Alcaligenaceae 28216|Betaproteobacteria S Domain of unknown function (DUF3394) - - - - - - - - - - - - DUF3394,DctM k59_257255_1 1121035.AUCH01000008_gene1053 1.75e-109 324.0 COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,2VH0J@28216|Betaproteobacteria,2KUCP@206389|Rhodocyclales 206389|Rhodocyclales L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing ruvB - 3.6.4.12 ko:K03551 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvB_C,RuvB_N k59_44159_1 324602.Caur_3096 1.41e-26 113.0 COG1197@1|root,COG1197@2|Bacteria,2G5UW@200795|Chloroflexi,375DR@32061|Chloroflexia 32061|Chloroflexia L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_726130_2 1182590.BN5_03760 3.07e-144 425.0 COG1861@1|root,COG1861@2|Bacteria,1QU5J@1224|Proteobacteria,1RNRG@1236|Gammaproteobacteria 1236|Gammaproteobacteria M PFAM transposase, IS4 family protein - - - - - - - - - - - - DDE_Tnp_1_4 k59_342493_1 498761.HM1_3108 1.21e-35 134.0 COG0150@1|root,COG0150@2|Bacteria,1TP9J@1239|Firmicutes,248BT@186801|Clostridia 186801|Clostridia F Phosphoribosylformylglycinamidine cyclo-ligase purM - 6.3.3.1 ko:K01933 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04208 RC01100 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k59_683554_1 983917.RGE_23810 1.35e-06 50.8 COG2603@1|root,COG2603@2|Bacteria,1N4T5@1224|Proteobacteria,2VIMH@28216|Betaproteobacteria,1KJPD@119065|unclassified Burkholderiales 28216|Betaproteobacteria H Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA selU - - ko:K06917 - - - - ko00000,ko01000,ko03016 - - - Rhodanese k59_683554_2 1460635.JCM19038_2592 2.86e-08 55.8 COG0583@1|root,COG0583@2|Bacteria,1UCV1@1239|Firmicutes,4HE6I@91061|Bacilli 91061|Bacilli K Transcriptional regulator gltR3 - - - - - - - - - - - HTH_1,LysR_substrate k59_683555_1 1157708.KB907462_gene903 1.69e-136 395.0 COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,2VIK8@28216|Betaproteobacteria,4A9SJ@80864|Comamonadaceae 28216|Betaproteobacteria BQ PFAM histone deacetylase superfamily hda - - - - - - - - - - - Hist_deacetyl k59_683555_2 1120999.JONM01000008_gene2010 2.64e-07 52.4 COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,2VKJJ@28216|Betaproteobacteria,2KQ80@206351|Neisseriales 206351|Neisseriales S ATPase family associated with various cellular activities (AAA) - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_470404_1 1336233.JAEH01000001_gene698 4.27e-75 247.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,2Q8TZ@267890|Shewanellaceae 1236|Gammaproteobacteria L PFAM UvrD REP helicase - - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - PDDEXK_1,Peptidase_M78,UvrD-helicase,UvrD_C k59_1997_1 1100720.ALKN01000028_gene2451 4.39e-215 609.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2VJ55@28216|Betaproteobacteria,4AAYC@80864|Comamonadaceae 28216|Betaproteobacteria H TIGRFAM acetolactate synthase, large subunit, biosynthetic type xsc - 2.2.1.6,2.3.3.15,4.1.1.8 ko:K01577,ko:K01652,ko:K03852 ko00290,ko00430,ko00630,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00430,map00630,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R01908,R03050,R04672,R04673,R05651,R08648 RC00027,RC00106,RC00620,RC01192,RC02744,RC02893,RC02903,RC02909 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1322910_1 765912.Thimo_1809 7.04e-72 227.0 COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,1RN8W@1236|Gammaproteobacteria,1WXNB@135613|Chromatiales 135613|Chromatiales BQ PFAM Histone deacetylase - - - - - - - - - - - - Hist_deacetyl k59_981960_1 629265.PMA4326_09935 1.82e-11 63.5 COG3756@1|root,COG3756@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - DUF1376 k59_981960_3 375286.mma_2211 7.13e-75 231.0 COG0270@1|root,COG0270@2|Bacteria,1R6IB@1224|Proteobacteria,2W3M1@28216|Betaproteobacteria,475QA@75682|Oxalobacteraceae 28216|Betaproteobacteria L DNA (cytosine-5-)-methyltransferase activity - - - - - - - - - - - - - k59_981960_9 1392540.P256_00733 2.39e-54 179.0 COG3645@1|root,COG3646@1|root,COG3645@2|Bacteria,COG3646@2|Bacteria,1R939@1224|Proteobacteria,1S2IZ@1236|Gammaproteobacteria,3NKV8@468|Moraxellaceae 1236|Gammaproteobacteria S Phage antirepressor protein KilAC domain - - - - - - - - - - - - ANT,Phage_pRha k59_257328_1 29581.BW37_02526 7.26e-09 54.7 COG2914@1|root,COG2914@2|Bacteria,1MZCH@1224|Proteobacteria,2VVNX@28216|Betaproteobacteria,4752K@75682|Oxalobacteraceae 28216|Betaproteobacteria S Belongs to the UPF0125 (RnfH) family rnfH - - ko:K09801 - - - - ko00000 - - - Ub-RnfH k59_172110_1 159087.Daro_4170 1.29e-32 125.0 COG0304@1|root,COG0304@2|Bacteria,1MV30@1224|Proteobacteria,2VI0P@28216|Betaproteobacteria,2KVGF@206389|Rhodocyclales 206389|Rhodocyclales IQ Beta-ketoacyl synthase, C-terminal domain - - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_1025053_1 519989.ECTPHS_01599 1.72e-128 382.0 COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,1MV3Z@1224|Proteobacteria,1RMAJ@1236|Gammaproteobacteria,1WWQB@135613|Chromatiales 135613|Chromatiales H Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose hldE - 2.7.1.167,2.7.7.70 ko:K03272 ko00540,ko01100,map00540,map01100 M00064 R05644,R05646 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CTP_transf_like,PfkB k59_470455_1 105559.Nwat_1044 1.22e-13 75.1 COG3115@1|root,COG3115@2|Bacteria,1QW35@1224|Proteobacteria 1224|Proteobacteria D cell septum assembly - - - - - - - - - - - - - k59_939356_1 883078.HMPREF9695_00461 6.59e-46 162.0 COG0683@1|root,COG0683@2|Bacteria 2|Bacteria E ABC-type branched-chain amino acid transport systems, periplasmic component - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_683667_2 1218108.KB908301_gene2465 4.5e-21 88.6 COG1226@1|root,32YV7@2|Bacteria,4NV56@976|Bacteroidetes,1IBGG@117743|Flavobacteriia 976|Bacteroidetes P Ion channel - - - - - - - - - - - - Ion_trans_2 k59_1025166_1 864051.BurJ1DRAFT_4088 3.3e-37 137.0 COG0564@1|root,COG0564@2|Bacteria,1MVDX@1224|Proteobacteria,2VI51@28216|Betaproteobacteria,1KJ5N@119065|unclassified Burkholderiales 28216|Betaproteobacteria J Responsible for synthesis of pseudouridine from uracil rluC - 5.4.99.24 ko:K06179 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_982068_1 1155718.KB891896_gene2198 7.25e-28 113.0 COG1926@1|root,COG1926@2|Bacteria,2GJUU@201174|Actinobacteria 201174|Actinobacteria Q phosphoribosyltransferase - GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - ko:K07100 - - - - ko00000 - - - DLH,Pribosyltran k59_172215_1 1123354.AUDR01000014_gene1074 1.26e-91 276.0 COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,2VHU0@28216|Betaproteobacteria,1KRHN@119069|Hydrogenophilales 119069|Hydrogenophilales F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran_N k59_214766_1 195250.CM001776_gene621 1.32e-33 130.0 COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1G175@1117|Cyanobacteria,1GYZ0@1129|Synechococcus 1117|Cyanobacteria H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate ribBA - 3.5.4.25,4.1.99.12 ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 - - iJN678.ribA DHBP_synthase,GTP_cyclohydro2 k59_598908_1 395493.BegalDRAFT_2435 7.98e-26 109.0 COG0568@1|root,COG0568@2|Bacteria,1MUDI@1224|Proteobacteria,1RN8V@1236|Gammaproteobacteria,461T2@72273|Thiotrichales 72273|Thiotrichales K Sigma-70 factor, region 1.2 rpoS - - ko:K03087 ko02026,ko05111,map02026,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_129548_1 680198.SCAB_65331 0.000539 47.8 COG1672@1|root,COG2319@1|root,COG1672@2|Bacteria,COG2319@2|Bacteria,2GJN3@201174|Actinobacteria 201174|Actinobacteria F WD-40 repeat - - - - - - - - - - - - ANAPC4_WD40,HTH_3,HTH_31,WD40 k59_129552_1 536019.Mesop_2541 7.06e-71 228.0 COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,2TQXA@28211|Alphaproteobacteria,43IA5@69277|Phyllobacteriaceae 28211|Alphaproteobacteria G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone zwf - 1.1.1.363,1.1.1.49 ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008 R00835,R02736,R10907 RC00001,RC00066 ko00000,ko00001,ko00002,ko01000,ko04147 - - - G6PD_C,G6PD_N k59_342784_1 742159.HMPREF0004_5500 6.87e-21 89.7 COG0561@1|root,COG0561@2|Bacteria,1R4WX@1224|Proteobacteria,2VI3C@28216|Betaproteobacteria,3T5DP@506|Alcaligenaceae 28216|Betaproteobacteria S hydrolases of the HAD superfamily - - - - - - - - - - - - Hydrolase_3 k59_342784_2 876044.IMCC3088_245 1.36e-45 166.0 COG0642@1|root,COG2205@2|Bacteria,1N17V@1224|Proteobacteria,1RNFK@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Histidine kinase - - 2.7.13.3 ko:K07641 ko02020,map02020 M00449 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_811462_1 1335757.SPICUR_09055 2.71e-31 114.0 COG1734@1|root,COG1734@2|Bacteria,1N7D8@1224|Proteobacteria,1SCG1@1236|Gammaproteobacteria 1236|Gammaproteobacteria T DnaK suppressor protein - - - ko:K06204 ko02026,map02026 - - - ko00000,ko00001,ko03000,ko03009,ko03021 - - - zf-dskA_traR k59_811462_2 331869.BAL199_26347 8.81e-34 129.0 COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,2TR63@28211|Alphaproteobacteria,4BP74@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria T GTP-binding protein TypA typA GO:0000027,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006996,GO:0008150,GO:0009266,GO:0009408,GO:0009409,GO:0009628,GO:0009987,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071826,GO:0071840 - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 k59_683795_1 1217720.ALOX01000057_gene1068 2.01e-42 155.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQPG@28211|Alphaproteobacteria,2JQ69@204441|Rhodospirillales 204441|Rhodospirillales T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains flbD - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_470635_1 1348657.M622_06815 1.83e-60 201.0 COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,2VH5S@28216|Betaproteobacteria,2KVN3@206389|Rhodocyclales 206389|Rhodocyclales J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX - 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - - tRNA-synt_1c k59_129588_1 1122201.AUAZ01000009_gene2878 8.27e-160 486.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,464D9@72275|Alteromonadaceae 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_470657_1 1125973.JNLC01000015_gene3399 3.65e-77 246.0 COG1884@1|root,COG1884@2|Bacteria,1MUXX@1224|Proteobacteria,2U39P@28211|Alphaproteobacteria,3K37Z@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I Methylmalonyl-CoA mutase - - 5.4.99.2,5.4.99.64 ko:K01848,ko:K20906 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - MM_CoA_mutase k59_896924_1 426114.THI_1095 4.65e-50 172.0 COG0683@1|root,COG0683@2|Bacteria,1MV5T@1224|Proteobacteria,2VI33@28216|Betaproteobacteria,1KJMC@119065|unclassified Burkholderiales 28216|Betaproteobacteria E Periplasmic binding protein - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_428074_1 1121405.dsmv_0691 2.16e-55 189.0 COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,42QDV@68525|delta/epsilon subdivisions,2WIRQ@28221|Deltaproteobacteria,2MN1S@213118|Desulfobacterales 68525|delta/epsilon subdivisions L PFAM transposase IS4 family protein - - - - - - - - - - - - DDE_Tnp_1 k59_385235_1 1415778.JQMM01000001_gene1070 2.46e-90 273.0 COG1703@1|root,COG1703@2|Bacteria,1MVI0@1224|Proteobacteria,1RP15@1236|Gammaproteobacteria,1J4Q4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E periplasmic protein kinase ArgK and related GTPases of G3E family argK GO:0003674,GO:0003824,GO:0003924,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111 - ko:K07588 - - - - ko00000,ko01000 - - - ArgK k59_257534_1 1249627.D779_2855 2.04e-20 87.0 COG3449@1|root,COG3449@2|Bacteria,1RF2U@1224|Proteobacteria,1S2JU@1236|Gammaproteobacteria,1WY8T@135613|Chromatiales 135613|Chromatiales L PFAM SOUL heme-binding protein - - - - - - - - - - - - SOUL k59_257534_2 118163.Ple7327_2339 1.09e-17 83.2 COG3367@1|root,COG3367@2|Bacteria 2|Bacteria M COGs COG3367 conserved - - 2.4.1.18 ko:K16149 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000 - GH57 - DUF1611,DUF1611_N,Peptidase_S8 k59_342854_1 62928.azo3520 5.76e-66 211.0 COG0614@1|root,COG0614@2|Bacteria,1MWVF@1224|Proteobacteria,2VJ7T@28216|Betaproteobacteria,2KU8W@206389|Rhodocyclales 206389|Rhodocyclales P ABC-type Fe3 -hydroxamate transport system, periplasmic component - - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 k59_342854_2 580332.Slit_2682 6.02e-12 61.6 2EG8X@1|root,33A0Q@2|Bacteria,1NMVN@1224|Proteobacteria,2VY0V@28216|Betaproteobacteria,44W3H@713636|Nitrosomonadales 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_342854_3 640081.Dsui_0527 2.89e-24 95.9 COG3027@1|root,COG3027@2|Bacteria,1N6YN@1224|Proteobacteria,2VVSV@28216|Betaproteobacteria,2KX9P@206389|Rhodocyclales 206389|Rhodocyclales D Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division - - - ko:K09888 - - - - ko00000,ko03036 - - - ZapA k59_1030360_1 1158150.KB906242_gene205 1.7e-24 108.0 COG5108@1|root,COG5108@2|Bacteria,1PIWB@1224|Proteobacteria,1SM2Z@1236|Gammaproteobacteria 1236|Gammaproteobacteria K DNA-dependent RNA polymerase - - 2.7.7.6 ko:K21313 - - - - ko00000,ko01000,ko03200 - - - RNA_pol,RPOL_N k59_814917_1 1207063.P24_13136 4.93e-14 75.5 COG4447@1|root,COG4447@2|Bacteria,1ND1J@1224|Proteobacteria,2U0UY@28211|Alphaproteobacteria,2JRNW@204441|Rhodospirillales 204441|Rhodospirillales S protein related to plant photosystem II stability assembly factor - - - - - - - - - - - - - k59_1156660_1 264462.Bd1337 2.05e-36 127.0 COG5531@1|root,COG5531@2|Bacteria,1N3MD@1224|Proteobacteria,430NN@68525|delta/epsilon subdivisions,2MT6T@213481|Bdellovibrionales,2WVYS@28221|Deltaproteobacteria 213481|Bdellovibrionales B SWI complex, BAF60b domains - - - - - - - - - - - - SWIB k59_176352_1 585.DR95_169 1.93e-20 87.0 COG0586@1|root,COG0586@2|Bacteria,1MX4M@1224|Proteobacteria,1RPB1@1236|Gammaproteobacteria,3Z1C2@583|Proteus 1236|Gammaproteobacteria S SNARE associated Golgi protein dedA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K03975 - - - - ko00000 - - - SNARE_assoc k59_176352_2 637911.AM305_04738 1.96e-43 158.0 COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,1RM89@1236|Gammaproteobacteria,1Y6XK@135625|Pasteurellales 135625|Pasteurellales L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL - - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C k59_49311_1 1353537.TP2_03040 6.74e-51 171.0 COG0331@1|root,COG0331@2|Bacteria,1MV6N@1224|Proteobacteria,2TRTT@28211|Alphaproteobacteria,2XKV6@285107|Thioclava 28211|Alphaproteobacteria I Malonyl CoA-acyl carrier protein transacylase fabD GO:0003674,GO:0003824,GO:0004312,GO:0004314,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016417,GO:0016419,GO:0016420,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.39 ko:K00645 ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 M00082 R01626,R11671 RC00004,RC00039,RC02727 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyl_transf_1 k59_49311_2 323098.Nwi_1688 3.63e-06 47.8 COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,2TQZG@28211|Alphaproteobacteria,3JW0B@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria IQ KR domain fabG GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_943517_1 398578.Daci_0196 2.94e-107 318.0 COG1028@1|root,COG1028@2|Bacteria,1MXNQ@1224|Proteobacteria,2VJQ2@28216|Betaproteobacteria,4A9SP@80864|Comamonadaceae 28216|Betaproteobacteria IQ PFAM Short-chain dehydrogenase reductase SDR - - - - - - - - - - - - adh_short,adh_short_C2 k59_943517_2 312153.Pnuc_1388 2.82e-43 152.0 COG1960@1|root,COG1960@2|Bacteria,1MVAH@1224|Proteobacteria,2VKD1@28216|Betaproteobacteria,1JZRA@119060|Burkholderiaceae 28216|Betaproteobacteria C acyl-CoA dehydrogenase acd12 - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1241972_1 1265502.KB905930_gene1445 9.2e-100 302.0 COG1960@1|root,COG1960@2|Bacteria,1MVQH@1224|Proteobacteria,2VIAN@28216|Betaproteobacteria,4AC8Z@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM acyl-CoA dehydrogenase domain protein abmD - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_604070_1 257313.BP1121 2.87e-119 368.0 COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,2VHP1@28216|Betaproteobacteria,3T6RQ@506|Alcaligenaceae 28216|Betaproteobacteria C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) aceE1 GO:0000287,GO:0003674,GO:0003824,GO:0004738,GO:0005488,GO:0005515,GO:0008150,GO:0008152,GO:0016491,GO:0016903,GO:0019842,GO:0030976,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0046872,GO:0046983,GO:0048037,GO:0050662,GO:0055114,GO:0097159,GO:1901363,GO:1901681 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transketolase_C,Transketolase_N k59_1113404_1 266834.SMc02899 1.08e-09 58.2 COG0077@1|root,COG0077@2|Bacteria,1MU60@1224|Proteobacteria,2TSUT@28211|Alphaproteobacteria,4B97X@82115|Rhizobiaceae 28211|Alphaproteobacteria E Prephenate dehydratase pheA - 4.2.1.51 ko:K04518 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024 R00691,R01373 RC00360 ko00000,ko00001,ko00002,ko01000 - - - PDT k59_1113404_2 631454.N177_1649 4.62e-42 147.0 COG2816@1|root,COG2816@2|Bacteria,1QGCX@1224|Proteobacteria,2TVMG@28211|Alphaproteobacteria,1JNRC@119043|Rhodobiaceae 28211|Alphaproteobacteria L NADH pyrophosphatase-like rudimentary NUDIX domain nudC - 3.6.1.22 ko:K03426 ko00760,ko01100,ko04146,map00760,map01100,map04146 - R00103,R03004,R11104 RC00002 ko00000,ko00001,ko01000 - - - NUDIX,NUDIX-like,zf-NADH-PPase k59_176427_1 543913.D521_0476 1.77e-89 292.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,2VH3F@28216|Betaproteobacteria,1KPRS@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria L DNA polymerase dnaE - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_673143_1 420324.KI912045_gene4583 6.48e-49 172.0 COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,2U139@28211|Alphaproteobacteria,1JVY8@119045|Methylobacteriaceae 28211|Alphaproteobacteria M Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - ko:K02005,ko:K13888 - M00709 - - ko00000,ko00002,ko02000 8.A.1 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_80157_1 1121035.AUCH01000004_gene287 3.47e-49 159.0 COG0292@1|root,COG0292@2|Bacteria,1RGU2@1224|Proteobacteria,2VRWF@28216|Betaproteobacteria,2KWC3@206389|Rhodocyclales 206389|Rhodocyclales J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit rplT - - ko:K02887 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L20 k59_80157_2 1121035.AUCH01000004_gene288 1.63e-14 73.6 COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,2VIM9@28216|Betaproteobacteria,2KUG4@206389|Rhodocyclales 206389|Rhodocyclales J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily pheS - 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Phe_tRNA-synt_N,tRNA-synt_2d k59_1013110_1 859657.RPSI07_2441 1.86e-26 103.0 COG1949@1|root,COG1949@2|Bacteria,1R9WX@1224|Proteobacteria,2VIA2@28216|Betaproteobacteria,1K394@119060|Burkholderiaceae 28216|Betaproteobacteria L 3'-to-5' exoribonuclease specific for small oligoribonucleotides orn - - ko:K13288 ko03008,map03008 - - - ko00000,ko00001,ko01000,ko03009,ko03019 - - - RNase_T k59_1105456_1 316055.RPE_3697 6.29e-40 136.0 COG3415@1|root,COG3415@2|Bacteria,1RJ69@1224|Proteobacteria,2UCXQ@28211|Alphaproteobacteria,3K69N@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L Transposase - - - ko:K07499 - - - - ko00000 - - - HTH_23,HTH_28,HTH_32,HTH_Tnp_IS630,HTH_Tnp_Tc3_2 k59_378223_1 640081.Dsui_1315 1.74e-101 312.0 COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,2VHKQ@28216|Betaproteobacteria,2KV0F@206389|Rhodocyclales 206389|Rhodocyclales J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) aspS - 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GAD,tRNA-synt_2,tRNA_anti-codon k59_378223_2 640081.Dsui_1316 6.3e-36 127.0 COG2928@1|root,COG2928@2|Bacteria,1MWT5@1224|Proteobacteria,2VH65@28216|Betaproteobacteria,2KV5C@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function (DUF502) - - - - - - - - - - - - DUF502 k59_881572_1 1122933.JNIY01000004_gene2319 2.98e-45 157.0 COG0730@1|root,COG0730@2|Bacteria,2GNW8@201174|Actinobacteria,4F1QJ@85016|Cellulomonadaceae 201174|Actinobacteria S Sulfite exporter TauE/SafE - - - ko:K07090 - - - - ko00000 - - - TauE k59_1184136_2 1384056.N787_05285 8.35e-41 140.0 COG2259@1|root,COG2259@2|Bacteria,1RHIY@1224|Proteobacteria,1SIZV@1236|Gammaproteobacteria,1X7C9@135614|Xanthomonadales 135614|Xanthomonadales S DoxX - - - ko:K15977 - - - - ko00000 - - - DoxX k59_203497_1 1051632.TPY_2935 1.22e-12 67.8 COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia 186801|Clostridia V ABC transporter - - - ko:K06147,ko:K11085 ko02010,map02010 - - - ko00000,ko00001,ko01000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_203497_2 1366046.HIMB11_00489 4.83e-06 49.7 COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,2TS37@28211|Alphaproteobacteria,3ZHC6@58840|unclassified Rhodobacteraceae 28211|Alphaproteobacteria M 3-deoxy-D-manno-octulosonic-acid transferase kdtA - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02527 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763 RC00009,RC00077,RC00247 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT30 - Glycos_transf_N k59_459554_1 1122135.KB893134_gene3212 4.23e-92 275.0 COG0745@1|root,COG0745@2|Bacteria,1MU3A@1224|Proteobacteria,2TR97@28211|Alphaproteobacteria 28211|Alphaproteobacteria KT Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain mtrA - - - - - - - - - - - Response_reg,Trans_reg_C k59_1312003_1 1410628.JNKS01000001_gene2452 3.1e-19 89.4 COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,24C3R@186801|Clostridia,27JBD@186928|unclassified Lachnospiraceae 186801|Clostridia P Oligopeptide/dipeptide transporter, C-terminal region oppF - - ko:K10823 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - ABC_tran,oligo_HPY k59_116276_1 1380394.JADL01000009_gene3293 1.68e-27 110.0 COG0477@1|root,COG2814@2|Bacteria,1MVKJ@1224|Proteobacteria,2TUK5@28211|Alphaproteobacteria,2JVMT@204441|Rhodospirillales 204441|Rhodospirillales EGP Sugar (and other) transporter - - - - - - - - - - - - Sugar_tr k59_502059_1 1122603.ATVI01000006_gene296 7.06e-15 75.1 COG0457@1|root,COG0457@2|Bacteria,1RAPH@1224|Proteobacteria,1S590@1236|Gammaproteobacteria,1X6FJ@135614|Xanthomonadales 135614|Xanthomonadales S Tetratricopeptide repeat - - - - - - - - - - - - - k59_502059_2 251221.35213551 2.66e-37 136.0 COG2370@1|root,COG2370@2|Bacteria,1G65K@1117|Cyanobacteria 1117|Cyanobacteria O HupE / UreJ protein - - - - - - - - - - - - HupE_UreJ_2 k59_378271_2 646529.Desaci_3744 1.18e-33 124.0 COG0745@1|root,COG0745@2|Bacteria,1TPWS@1239|Firmicutes,25AZ2@186801|Clostridia,2605V@186807|Peptococcaceae 186801|Clostridia K PFAM response regulator receiver phoB - - ko:K02483,ko:K07658,ko:K07668 ko02020,map02020 M00434,M00459 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_715200_1 1163617.SCD_n01977 7.51e-39 142.0 COG0686@1|root,COG0686@2|Bacteria,1QTX1@1224|Proteobacteria,2VHD1@28216|Betaproteobacteria 28216|Betaproteobacteria C Belongs to the AlaDH PNT family ald - 1.4.1.1 ko:K00259 ko00250,ko00430,ko01100,map00250,map00430,map01100 - R00396 RC00008 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N k59_673252_1 1192124.LIG30_1205 1.38e-56 188.0 COG4301@1|root,COG4301@2|Bacteria,1MUCG@1224|Proteobacteria,2VJHK@28216|Betaproteobacteria,1K52I@119060|Burkholderiaceae 28216|Betaproteobacteria S Methyltransferase egtD - - - - - - - - - - - Methyltransf_33 k59_585018_1 1174684.EBMC1_02025 2.41e-26 105.0 COG2057@1|root,COG2057@2|Bacteria,1MY3S@1224|Proteobacteria,2TUZ8@28211|Alphaproteobacteria,2KDGT@204457|Sphingomonadales 204457|Sphingomonadales I Acyl CoA acetate 3-ketoacid CoA transferase beta subunit - - 2.8.3.12 ko:K01040 ko00643,ko00650,ko01120,map00643,map00650,map01120 - R04000,R05509 RC00012,RC00131,RC00137 ko00000,ko00001,ko01000 - - - CoA_trans k59_585018_2 323848.Nmul_A1876 2.52e-18 81.6 COG5483@1|root,COG5483@2|Bacteria,1RDGV@1224|Proteobacteria,2VRBM@28216|Betaproteobacteria,37326@32003|Nitrosomonadales 28216|Betaproteobacteria S Protein of unknown function, DUF488 - - - - - - - - - - - - DUF488 k59_1105558_1 404380.Gbem_0839 4.44e-31 125.0 COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,42MMA@68525|delta/epsilon subdivisions,2WIZB@28221|Deltaproteobacteria,43UEF@69541|Desulfuromonadales 28221|Deltaproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamA - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_928566_1 1205680.CAKO01000040_gene711 3.7e-77 241.0 COG4608@1|root,COG4608@2|Bacteria,1NU4K@1224|Proteobacteria,2TQTV@28211|Alphaproteobacteria,2JPRD@204441|Rhodospirillales 204441|Rhodospirillales E Belongs to the ABC transporter superfamily - - - ko:K10823 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - ABC_tran,oligo_HPY k59_1137034_1 266264.Rmet_2492 7.44e-132 400.0 COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,2VKDZ@28216|Betaproteobacteria,1K16W@119060|Burkholderiaceae 28216|Betaproteobacteria C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate acnA - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_970918_1 1123227.KB899333_gene664 3.77e-29 113.0 COG0451@1|root,COG0451@2|Bacteria,1MW32@1224|Proteobacteria,2TTTU@28211|Alphaproteobacteria,2JPSX@204441|Rhodospirillales 204441|Rhodospirillales M NmrA-like family dfrA - 1.1.1.219 ko:K00091 - - - - ko00000,ko01000 - - - Epimerase k59_970918_2 269482.Bcep1808_4688 1.62e-19 87.8 COG1213@1|root,COG1213@2|Bacteria,1RB54@1224|Proteobacteria,2VN6F@28216|Betaproteobacteria,1K0RM@119060|Burkholderiaceae 28216|Betaproteobacteria M MobA-like NTP transferase domain - - - - - - - - - - - - NTP_transf_3 k59_1184280_1 1216976.AX27061_2482 5.76e-10 61.6 COG0285@1|root,COG0285@2|Bacteria,1MVCH@1224|Proteobacteria,2VI0H@28216|Betaproteobacteria,3T1IK@506|Alcaligenaceae 28216|Betaproteobacteria H Belongs to the folylpolyglutamate synthase family folC - 6.3.2.12,6.3.2.17 ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 - - - Mur_ligase_C,Mur_ligase_M k59_1184280_2 1286093.C266_18131 1.9e-06 52.0 COG3147@1|root,COG3147@2|Bacteria,1R7IV@1224|Proteobacteria,2VPE1@28216|Betaproteobacteria,1K0HF@119060|Burkholderiaceae 28216|Betaproteobacteria S PFAM Sporulation domain protein dedD - - ko:K03749 - - - - ko00000 - - - SPOR k59_804550_1 864073.HFRIS_018257 1.59e-106 315.0 COG2513@1|root,COG2513@2|Bacteria,1N4VT@1224|Proteobacteria,2VI8S@28216|Betaproteobacteria,47299@75682|Oxalobacteraceae 28216|Betaproteobacteria G Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate prpB - 4.1.3.30,5.4.2.9 ko:K01841,ko:K03417 ko00440,ko00640,ko01100,ko01120,ko01130,map00440,map00640,map01100,map01120,map01130 - R00409,R00661 RC00286,RC00287,RC02792 ko00000,ko00001,ko01000 - - - PEP_mutase k59_158656_1 1000565.METUNv1_03314 4.89e-105 317.0 COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,2VJ07@28216|Betaproteobacteria,2KVNA@206389|Rhodocyclales 206389|Rhodocyclales H Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis ubiB - - ko:K03688 - - - - ko00000 - - - ABC1 k59_80356_1 1123367.C666_05545 2.43e-68 229.0 COG2176@1|root,COG2176@2|Bacteria,1QUVW@1224|Proteobacteria,2VHZ3@28216|Betaproteobacteria,2KUQR@206389|Rhodocyclales 206389|Rhodocyclales L DNA polymerase III - - 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T k59_970930_1 522306.CAP2UW1_2025 3.9e-115 349.0 COG0443@1|root,COG0443@2|Bacteria,1MVQI@1224|Proteobacteria,2VHGV@28216|Betaproteobacteria,1KPNB@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria O Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB hscA GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0022607,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043531,GO:0043933,GO:0044085,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0070887,GO:0071310,GO:0071840,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141 - ko:K04044 - - - - ko00000,ko03110 1.A.33 - - HSP70 k59_1063511_1 2340.JV46_28050 4.28e-17 77.4 COG0790@1|root,COG0790@2|Bacteria,1PDUX@1224|Proteobacteria,1RW86@1236|Gammaproteobacteria,1JBN1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Sel1-like repeats. - - - - - - - - - - - - Sel1 k59_970972_1 1089550.ATTH01000002_gene36 1.14e-23 101.0 COG0841@1|root,COG0841@2|Bacteria,4NDZG@976|Bacteroidetes,1FJTT@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes V AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran k59_970972_2 1120985.AUMI01000011_gene359 3.41e-38 141.0 COG0477@1|root,COG2814@2|Bacteria,1UIY9@1239|Firmicutes,4H4SM@909932|Negativicutes 909932|Negativicutes EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_585173_1 498211.CJA_3288 6.28e-63 204.0 COG4973@1|root,COG4973@2|Bacteria,1MUJJ@1224|Proteobacteria,1RMJG@1236|Gammaproteobacteria,1FG7C@10|Cellvibrio 1236|Gammaproteobacteria D Phage integrase, N-terminal SAM-like domain xerC GO:0000150,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008907,GO:0009009,GO:0009037,GO:0009987,GO:0015074,GO:0032991,GO:0034641,GO:0042150,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0071139,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363 - ko:K03733 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_1227132_1 886293.Sinac_1445 8.97e-31 122.0 COG0247@1|root,COG0247@2|Bacteria,2IXBR@203682|Planctomycetes 203682|Planctomycetes C Cysteine-rich domain - - - ko:K11473 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - CCG,Fer4_7,Fer4_8 k59_1312205_1 1123023.JIAI01000001_gene6533 2.1e-62 201.0 COG3384@1|root,COG3384@2|Bacteria,2GJDG@201174|Actinobacteria 201174|Actinobacteria S PFAM Extradiol ring-cleavage dioxygenase, class III enzyme, subunit B - - - - - - - - - - - - LigB k59_838639_1 1458357.BG58_21470 7.87e-58 202.0 COG4258@1|root,COG4258@2|Bacteria,1MU1E@1224|Proteobacteria,2VHXY@28216|Betaproteobacteria,1K0YC@119060|Burkholderiaceae 28216|Betaproteobacteria S MMPL family - - - - - - - - - - - - MMPL k59_544858_1 247633.GP2143_17911 3.21e-93 281.0 COG2141@1|root,COG2141@2|Bacteria 2|Bacteria C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - - - - - - - - - - Bac_luciferase k59_203720_1 1502851.FG93_00150 5.18e-76 236.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TSGZ@28211|Alphaproteobacteria,3JUDN@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L IS116 IS110 IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_715409_1 1123274.KB899407_gene127 2.57e-11 69.3 COG0167@1|root,COG0493@1|root,COG1145@1|root,COG0167@2|Bacteria,COG0493@2|Bacteria,COG1145@2|Bacteria 2|Bacteria C 4fe-4S ferredoxin, iron-sulfur binding domain protein - - 1.3.98.1 ko:K00226 ko00240,ko01100,map00240,map01100 M00051 R01867 RC00051 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh,Fer4,Fer4_20,Fer4_7,GXGXG,Pyr_redox_2,Pyr_redox_3 k59_247039_1 1218084.BBJK01000135_gene7223 1.8e-88 276.0 COG0492@1|root,COG0492@2|Bacteria,1MVX2@1224|Proteobacteria,2VM3V@28216|Betaproteobacteria,1K4AE@119060|Burkholderiaceae 28216|Betaproteobacteria C FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2,cNMP_binding k59_838673_2 1313304.CALK_0048 3.96e-12 67.0 COG2119@1|root,COG2119@2|Bacteria 2|Bacteria O membrane - - - - - - - - - - - - UPF0016 k59_247068_1 1430440.MGMSRv2_1968 2.96e-27 115.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,PAS_9,dCache_2 k59_804728_1 292415.Tbd_0095 2.67e-103 315.0 COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,2VHFX@28216|Betaproteobacteria,1KRG4@119069|Hydrogenophilales 119069|Hydrogenophilales J Beta-Casp domain - - - ko:K07576 - - - - ko00000 - - - Beta-Casp,Lactamase_B,RMMBL k59_247098_1 1123508.JH636439_gene1935 6.49e-18 90.5 COG5362@1|root,COG5410@1|root,COG5362@2|Bacteria,COG5410@2|Bacteria,2J3WY@203682|Planctomycetes 203682|Planctomycetes S Terminase-like family - - - - - - - - - - - - Terminase_6,Terminase_6C k59_636996_1 388399.SSE37_00930 3.21e-94 293.0 COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2TQY9@28211|Alphaproteobacteria 28211|Alphaproteobacteria S transport system fused permease components - - - - - - - - - - - - DctM k59_843301_1 331869.BAL199_03334 6.58e-46 159.0 COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,2TTMV@28211|Alphaproteobacteria,4BQWG@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Zinc-binding dehydrogenase - - 1.1.1.1 ko:K00001,ko:K13953 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_843301_2 1132442.KB889752_gene909 9.7e-27 107.0 COG2873@1|root,COG2873@2|Bacteria,1VYCY@1239|Firmicutes,4H9X5@91061|Bacilli,1ZS2F@1386|Bacillus 91061|Bacilli E O-acetylhomoserine metY - 2.5.1.49 ko:K01740 ko00270,ko01100,map00270,map01100 - R01287,R04859 RC00020,RC02821,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP k59_1232719_1 349163.Acry_2893 5.21e-10 58.9 COG1878@1|root,COG1878@2|Bacteria,1MVWU@1224|Proteobacteria,2TUQ1@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Metal-dependent hydrolase - - - - - - - - - - - - Cyclase k59_1232719_2 1095769.CAHF01000011_gene2283 4.68e-57 182.0 COG2030@1|root,COG2030@2|Bacteria,1RHPH@1224|Proteobacteria,2VQFV@28216|Betaproteobacteria,474FZ@75682|Oxalobacteraceae 28216|Betaproteobacteria I Acyl dehydratase - - - - - - - - - - - - MaoC_dehydratas k59_1317720_1 762376.AXYL_01681 3.46e-75 238.0 COG3146@1|root,COG3146@2|Bacteria,1MU35@1224|Proteobacteria,2VH0Z@28216|Betaproteobacteria,3T2JI@506|Alcaligenaceae 28216|Betaproteobacteria S Peptidogalycan biosysnthesis/recognition - - - ko:K09919 - - - - ko00000 - - - FemAB_like k59_164271_1 351348.Maqu_0114 5.72e-18 87.8 COG0477@1|root,COG2814@2|Bacteria,1MU1I@1224|Proteobacteria,1RNTG@1236|Gammaproteobacteria,46CFS@72275|Alteromonadaceae 1236|Gammaproteobacteria P COG0477 Permeases of the major facilitator superfamily - - - ko:K08170 - M00702 - - ko00000,ko00002,ko01504,ko02000 2.A.1.3.23,2.A.1.3.59 - - MFS_1 k59_465298_1 443152.MDG893_08190 7.76e-38 144.0 COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,1RMIQ@1236|Gammaproteobacteria,464S3@72275|Alteromonadaceae 1236|Gammaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - ko:K03072 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD-TM1,SecD_SecF,Sec_GG k59_292413_1 1123360.thalar_02885 7.93e-20 89.7 COG0843@1|root,COG0843@2|Bacteria,1R57U@1224|Proteobacteria,2U068@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Cytochrome C and Quinol oxidase polypeptide I - - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 k59_292413_2 1244869.H261_01542 2.54e-22 95.1 COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,2TRD8@28211|Alphaproteobacteria,2JPAB@204441|Rhodospirillales 204441|Rhodospirillales O Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group ctaB - 2.5.1.141 ko:K02257 ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714 M00154 R07411 RC01786 ko00000,ko00001,ko00002,ko01000,ko01006,ko03029 - - - UbiA k59_976582_1 572477.Alvin_2367 1.83e-70 216.0 COG0049@1|root,COG0049@2|Bacteria,1MXC8@1224|Proteobacteria,1RN77@1236|Gammaproteobacteria,1WWE7@135613|Chromatiales 135613|Chromatiales J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA rpsG - - ko:K02992 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S7 k59_1141937_1 1211115.ALIQ01000199_gene535 8.92e-168 489.0 COG0189@1|root,COG0454@1|root,COG0189@2|Bacteria,COG0456@2|Bacteria,1MVN2@1224|Proteobacteria,2TUT9@28211|Alphaproteobacteria 28211|Alphaproteobacteria HJ Cyanophycin synthetase cphA - - - - - - - - - - - Acetyltransf_1,Dala_Dala_lig_C,GSH-S_ATP,RimK k59_1141937_2 991905.SL003B_2638 3.87e-42 152.0 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,2TSCY@28211|Alphaproteobacteria,4BPUM@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E Asparagine synthase asnO - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_976635_1 1121935.AQXX01000137_gene3868 4.32e-69 228.0 COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,1RMP9@1236|Gammaproteobacteria,1XHFB@135619|Oceanospirillales 135619|Oceanospirillales M Lipoprotein releasing system, transmembrane protein lolC - - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD k59_934400_1 1158292.JPOE01000002_gene3107 3.4e-15 74.7 COG0476@1|root,COG0476@2|Bacteria,1MW7H@1224|Proteobacteria,2VI1U@28216|Betaproteobacteria,1KJSX@119065|unclassified Burkholderiales 28216|Betaproteobacteria H ThiF family thiF - 2.7.7.80 ko:K21029 ko04122,map04122 - R07459 RC00043 ko00000,ko00001,ko01000 - - - ThiF k59_934400_2 266779.Meso_2458 3.22e-71 232.0 COG0500@1|root,COG2267@1|root,COG2226@2|Bacteria,COG2267@2|Bacteria,1NWX3@1224|Proteobacteria,2TURQ@28211|Alphaproteobacteria,43PQD@69277|Phyllobacteriaceae 28211|Alphaproteobacteria Q Methyltransferase - - - - - - - - - - - - Methyltransf_11,Methyltransf_25,Ubie_methyltran k59_41623_1 1211115.ALIQ01000174_gene3566 3.3e-18 84.3 COG1304@1|root,COG1304@2|Bacteria,1MUEZ@1224|Proteobacteria,2TQNW@28211|Alphaproteobacteria,3NC6W@45404|Beijerinckiaceae 28211|Alphaproteobacteria C FMN-dependent dehydrogenase mdlB - 1.1.2.3,1.1.99.31 ko:K00101,ko:K15054 ko00620,ko00627,ko01100,ko01120,map00620,map00627,map01100,map01120 - R00196,R04160,R07664 RC00044,RC00240 ko00000,ko00001,ko01000 - - - FMN_dh k59_423482_1 1246995.AFR_23755 1.46e-12 71.2 COG3971@1|root,COG3971@2|Bacteria,2GPBI@201174|Actinobacteria,4DB39@85008|Micromonosporales 201174|Actinobacteria Q hydratase cmtF - 4.2.1.80 ko:K02554 ko00360,ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00360,map00362,map00621,map00622,map01100,map01120,map01220 M00545,M00569 R02601,R04781 RC00750,RC01213 br01602,ko00000,ko00001,ko00002,ko01000 - - - FAA_hydrolase k59_1142021_1 652103.Rpdx1_0728 5.64e-11 61.6 COG2050@1|root,COG2050@2|Bacteria,1RGVD@1224|Proteobacteria,2U9MH@28211|Alphaproteobacteria,3JY97@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria Q Thioesterase superfamily - - - - - - - - - - - - 4HBT k59_1142021_2 1265502.KB905932_gene1926 5.55e-74 233.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VHD3@28216|Betaproteobacteria,4A9Q4@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM acyl-CoA dehydrogenase domain protein ivd - 1.3.8.4 ko:K00253 ko00280,ko01100,map00280,map01100 M00036 R04095 RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_209444_1 357808.RoseRS_3688 5.51e-27 100.0 COG1598@1|root,COG1598@2|Bacteria,2G9PD@200795|Chloroflexi 200795|Chloroflexi S HicB_like antitoxin of bacterial toxin-antitoxin system - - - - - - - - - - - - HicB_lk_antitox k59_209444_2 98439.AJLL01000107_gene4299 5.92e-08 50.4 COG1724@1|root,COG1724@2|Bacteria,1G9BE@1117|Cyanobacteria,1JMKK@1189|Stigonemataceae 1117|Cyanobacteria N HicA toxin of bacterial toxin-antitoxin, - - - - - - - - - - - - HicA_toxin k59_590954_1 519989.ECTPHS_07451 9.67e-112 330.0 COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,1RP6Q@1236|Gammaproteobacteria,1WW00@135613|Chromatiales 135613|Chromatiales H Belongs to the ALAD family - - 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ALAD k59_590954_2 1089552.KI911559_gene1828 8.3e-07 50.4 COG0679@1|root,COG0679@2|Bacteria,1N1X9@1224|Proteobacteria,2TV2I@28211|Alphaproteobacteria,2JRYA@204441|Rhodospirillales 204441|Rhodospirillales S Membrane transport protein - - - ko:K07088 - - - - ko00000 - - - Mem_trans k59_508050_1 1448139.AI20_06770 8.8e-48 167.0 COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,1RM8U@1236|Gammaproteobacteria,1Y3NB@135624|Aeromonadales 135624|Aeromonadales M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids - - 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 - R00401 RC00285 ko00000,ko00001,ko01000,ko01011 - - - Ala_racemase_C,Ala_racemase_N k59_164531_1 247490.KSU1_C0561 0.000597 43.5 COG0674@1|root,COG0674@2|Bacteria,2IYDT@203682|Planctomycetes 2|Bacteria C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin porA - 1.2.7.1 ko:K00169 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR_N k59_164531_2 933262.AXAM01000011_gene1757 3.42e-94 283.0 COG1013@1|root,COG1013@2|Bacteria,1MUY9@1224|Proteobacteria,42MQY@68525|delta/epsilon subdivisions,2WJGJ@28221|Deltaproteobacteria,2MJ2R@213118|Desulfobacterales 28221|Deltaproteobacteria C Thiamine pyrophosphate enzyme, C-terminal TPP binding domain - - 1.2.7.1,1.2.7.7 ko:K00170,ko:K00187 ko00010,ko00020,ko00280,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R07160,R08034,R08566,R08567 RC00004,RC00250,RC02742,RC02833,RC02856 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C k59_1142084_1 1122194.AUHU01000001_gene74 5.76e-14 76.3 COG2206@1|root,COG2206@2|Bacteria,1MW7F@1224|Proteobacteria,1RPEZ@1236|Gammaproteobacteria,465ZX@72275|Alteromonadaceae 1236|Gammaproteobacteria T COG2206 HD-GYP domain - - - - - - - - - - - - DUF3391,HD,HD_5 k59_591011_1 395495.Lcho_4134 1.81e-53 179.0 COG3303@1|root,COG3303@2|Bacteria,1RG2D@1224|Proteobacteria,2VRXP@28216|Betaproteobacteria,1KNJI@119065|unclassified Burkholderiales 28216|Betaproteobacteria P Doubled CXXCH motif (Paired_CXXCH_1) - - - - - - - - - - - - Paired_CXXCH_1 k59_763644_1 234267.Acid_1509 2.33e-23 103.0 COG4219@1|root,COG4219@2|Bacteria,3Y301@57723|Acidobacteria 57723|Acidobacteria KT Peptidase M56 - - - - - - - - - - - - - k59_209539_1 1219049.SP5_046_00030 7.16e-25 100.0 COG2885@1|root,COG2885@2|Bacteria,1MYBP@1224|Proteobacteria,2U787@28211|Alphaproteobacteria,2K074@204457|Sphingomonadales 204457|Sphingomonadales M Belongs to the ompA family - - - - - - - - - - - - Gly-zipper_Omp,OmpA k59_577334_2 391038.Bphy_4904 4.71e-20 89.4 COG1484@1|root,COG1484@2|Bacteria,1MVU2@1224|Proteobacteria,2W1UV@28216|Betaproteobacteria,1K50U@119060|Burkholderiaceae 28216|Betaproteobacteria L PFAM IstB domain protein ATP-binding protein - - - - - - - - - - - - IstB_IS21 k59_1351194_1 1123354.AUDR01000017_gene3 4.16e-52 178.0 COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,2VH7F@28216|Betaproteobacteria,1KRBD@119069|Hydrogenophilales 119069|Hydrogenophilales E Glycosyl transferase family, a/b domain - - 2.4.2.18 ko:K00766 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R01073 RC00440 ko00000,ko00001,ko00002,ko01000 - - - Glycos_trans_3N,Glycos_transf_3 k59_150936_1 97139.C824_04759 1.28e-28 118.0 COG5545@1|root,COG5545@2|Bacteria,1TQNX@1239|Firmicutes,2495S@186801|Clostridia,36EHX@31979|Clostridiaceae 186801|Clostridia S virulence-associated E family protein - - - - - - - - - - - - VirE k59_1219256_1 483219.LILAB_12465 5.33e-48 174.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,42MW3@68525|delta/epsilon subdivisions,2WJRZ@28221|Deltaproteobacteria,2YW7G@29|Myxococcales 28221|Deltaproteobacteria H Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate ppsA - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2101 PEP-utilizers,PEP-utilizers_C,PPDK_N k59_796920_1 105425.BBPL01000022_gene934 5.37e-10 67.0 COG0515@1|root,COG0515@2|Bacteria,2GIV0@201174|Actinobacteria,2NGSY@228398|Streptacidiphilus 201174|Actinobacteria KLT Protein tyrosine kinase - - - - - - - - - - - - PQQ_2,Pkinase k59_831962_1 1041159.AZUW01000041_gene2571 1.42e-07 52.8 COG1995@1|root,COG1995@2|Bacteria,1MXGJ@1224|Proteobacteria,2TUEU@28211|Alphaproteobacteria,4BCWC@82115|Rhizobiaceae 28211|Alphaproteobacteria H Pyridoxal phosphate biosynthetic protein PdxA pdxA_2 - 1.1.1.262 ko:K00097 ko00750,ko01100,map00750,map01100 M00124 R05681,R05837,R07406 RC00089,RC00675,RC01475 ko00000,ko00001,ko00002,ko01000 - - - PdxA k59_831962_2 1207063.P24_14519 9.31e-63 202.0 COG1063@1|root,COG1063@2|Bacteria,1QTU5@1224|Proteobacteria,2TW9Q@28211|Alphaproteobacteria,2JQP9@204441|Rhodospirillales 204441|Rhodospirillales E Alanine dehydrogenase/PNT, C-terminal domain - - - - - - - - - - - - ADH_N,ADH_zinc_N k59_537114_1 1120965.AUBV01000001_gene3353 4.98e-18 84.0 COG0225@1|root,COG0229@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,4NMAJ@976|Bacteroidetes,47TCV@768503|Cytophagia 976|Bacteroidetes O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine msrB - 1.8.4.11,1.8.4.12 ko:K07304,ko:K12267 - - - - ko00000,ko01000 - - - PMSR,SelR k59_72728_1 1265313.HRUBRA_00683 1.25e-15 78.2 COG3540@1|root,COG3540@2|Bacteria,1MWAF@1224|Proteobacteria,1RNY4@1236|Gammaproteobacteria,1J7FS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG3540 Phosphodiesterase alkaline phosphatase D phoD - 3.1.3.1 ko:K01113 ko00790,ko01100,ko02020,map00790,map01100,map02020 M00126 R04620 RC00017 ko00000,ko00001,ko00002,ko01000 - - - PhoD,PhoD_N k59_72728_2 504832.OCAR_6922 9.27e-09 56.6 COG4731@1|root,COG4731@2|Bacteria,1N7E7@1224|Proteobacteria,2UHSI@28211|Alphaproteobacteria,3JY51@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2147) - - - - - - - - - - - - DUF2147 k59_27726_2 1123261.AXDW01000005_gene2544 8.36e-27 106.0 COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,1RMN0@1236|Gammaproteobacteria,1X3I1@135614|Xanthomonadales 135614|Xanthomonadales O Belongs to the peptidase M48B family htpX - - ko:K03799 - M00743 - - ko00000,ko00002,ko01000,ko01002 - - - Peptidase_M48 k59_796950_1 351016.RAZWK3B_09231 1.13e-12 67.8 COG0589@1|root,COG0589@2|Bacteria,1PEVZ@1224|Proteobacteria,2UCDM@28211|Alphaproteobacteria,2P3V5@2433|Roseobacter 28211|Alphaproteobacteria T COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - - - - - - - - - - Usp k59_796950_2 177439.DP1202 2.42e-13 70.1 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2WJ1T@28221|Deltaproteobacteria,2MHX9@213118|Desulfobacterales 28221|Deltaproteobacteria IQ AMP-binding enzyme C-terminal domain - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_577387_1 318586.Pden_3482 2.59e-44 162.0 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria,2PUZM@265|Paracoccus 28211|Alphaproteobacteria G C4-dicarboxylate ABC transporter permease - - - - - - - - - - - - DctM k59_707675_1 395495.Lcho_1718 1.69e-36 134.0 COG0500@1|root,COG2226@2|Bacteria,1MZVH@1224|Proteobacteria,2VZ2M@28216|Betaproteobacteria 28216|Betaproteobacteria H Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - - - - - - - - - - Methyltransf_25 k59_707675_2 1232410.KI421426_gene1371 1.22e-50 170.0 COG2928@1|root,COG2928@2|Bacteria,1R79M@1224|Proteobacteria,42N61@68525|delta/epsilon subdivisions,2WM0D@28221|Deltaproteobacteria,43S57@69541|Desulfuromonadales 28221|Deltaproteobacteria S Protein of unknown function (DUF502) - - - - - - - - - - - - DUF502 k59_707675_3 1828.JOKB01000066_gene4881 1.69e-13 72.0 COG1028@1|root,COG1028@2|Bacteria,2ICPI@201174|Actinobacteria,4FVG3@85025|Nocardiaceae 201174|Actinobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short,adh_short_C2 k59_1219311_1 1287116.X734_23770 3.93e-43 154.0 COG2197@1|root,COG2267@1|root,COG2197@2|Bacteria,COG2267@2|Bacteria,1QYHB@1224|Proteobacteria,2TXR9@28211|Alphaproteobacteria 28211|Alphaproteobacteria IK Serine aminopeptidase, S33 - - - - - - - - - - - - Abhydrolase_1,GerE,Hydrolase_4,Trans_reg_C k59_1096740_1 477184.KYC_14912 2.27e-41 137.0 COG2963@1|root,COG2963@2|Bacteria,1MZ3D@1224|Proteobacteria,2VTZ8@28216|Betaproteobacteria,3T7UX@506|Alcaligenaceae 28216|Betaproteobacteria L Transposase - - - ko:K07497 - - - - ko00000 - - - HTH_Tnp_1 k59_1096740_2 375451.RD1_3449 3.16e-23 97.1 COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,2P3AF@2433|Roseobacter 28211|Alphaproteobacteria L COG2801 Transposase and inactivated derivatives - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve,rve_3 k59_370783_1 1247726.MIM_c41110 7.23e-10 60.1 COG1042@1|root,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2VI9R@28216|Betaproteobacteria,3T74P@506|Alcaligenaceae 28216|Betaproteobacteria C CoA binding domain - - - - - - - - - - - - ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,Acetyltransf_4,CoA_binding_2,Succ_CoA_lig k59_370783_2 477184.KYC_08800 8.75e-103 308.0 COG1960@1|root,COG1960@2|Bacteria,1MX17@1224|Proteobacteria,2VM2C@28216|Betaproteobacteria,3T6AI@506|Alcaligenaceae 28216|Betaproteobacteria C Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1176608_1 94624.Bpet3237 9.99e-76 233.0 COG0842@1|root,COG0842@2|Bacteria,1MUH1@1224|Proteobacteria,2VJMJ@28216|Betaproteobacteria,3T36Z@506|Alcaligenaceae 28216|Betaproteobacteria V Transport permease protein yadH - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane k59_1219341_2 290633.GOX0879 3.32e-58 190.0 COG3751@1|root,COG3751@2|Bacteria,1REIC@1224|Proteobacteria,2TVV4@28211|Alphaproteobacteria,2JSDY@204441|Rhodospirillales 204441|Rhodospirillales O 2OG-Fe(II) oxygenase superfamily - - - - - - - - - - - - 2OG-FeII_Oxy_3 k59_1219341_3 227377.CBU_2004 8.8e-26 105.0 COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,1RR6K@1236|Gammaproteobacteria,1JD2Q@118969|Legionellales 118969|Legionellales M Glycosyltransferase family 9 (heptosyltransferase) rfaQ - - ko:K12982 - - - - ko00000,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 k59_665006_1 1348657.M622_16655 1.1e-53 186.0 COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,2VIB1@28216|Betaproteobacteria,2KUYS@206389|Rhodocyclales 206389|Rhodocyclales C nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC napA - - ko:K02567 ko00910,ko01120,map00910,map01120 M00529,M00530 R00798,R01106 RC02812 ko00000,ko00001,ko00002,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_665006_2 1121035.AUCH01000002_gene1468 1.13e-15 75.1 COG3043@1|root,COG3043@2|Bacteria,1RHGD@1224|Proteobacteria,2VTPE@28216|Betaproteobacteria,2KXA1@206389|Rhodocyclales 206389|Rhodocyclales C Electron transfer subunit of the periplasmic nitrate reductase complex NapAB - - - ko:K02568 ko00910,ko01120,map00910,map01120 M00529,M00530 R00798 RC02812 ko00000,ko00001,ko00002 - - - NapB k59_409363_1 1122130.AUHN01000006_gene2104 3e-14 70.1 COG1734@1|root,COG1734@2|Bacteria,2GJBE@201174|Actinobacteria 201174|Actinobacteria T Transcriptional regulator, TraR DksA family - - - ko:K06204 ko02026,map02026 - - - ko00000,ko00001,ko03000,ko03009,ko03021 - - - zf-dskA_traR k59_409363_2 1296990.H845_2502 3.98e-16 81.6 COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,2TR3N@28211|Alphaproteobacteria,2JPW3@204441|Rhodospirillales 204441|Rhodospirillales J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1,zf-FPG_IleRS k59_370833_1 1382359.JIAL01000001_gene504 5.03e-19 86.7 COG2378@1|root,COG2378@2|Bacteria,3Y4C6@57723|Acidobacteria,2JJ12@204432|Acidobacteriia 204432|Acidobacteriia K WYL domain - - - - - - - - - - - - HTH_11,WYL k59_196115_1 686578.AFFX01000004_gene3586 3.09e-24 98.6 2CJ6B@1|root,32S9B@2|Bacteria,1N2I4@1224|Proteobacteria,1S8Z8@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Thermostable hemolysin - - - - - - - - - - - - T_hemolysin k59_196115_2 575588.ACPN01000084_gene1062 2.89e-06 48.5 COG1022@1|root,COG1022@2|Bacteria 2|Bacteria I Amp-dependent synthetase and ligase - - - - - - - - - - - - AMP-binding,Haem_oxygenas_2 k59_1130532_2 1229205.BUPH_04252 8.3e-35 134.0 COG0247@1|root,COG0277@1|root,COG1146@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,COG1146@2|Bacteria,1MU43@1224|Proteobacteria,2VHYU@28216|Betaproteobacteria,1K40G@119060|Burkholderiaceae 28216|Betaproteobacteria C FAD linked oxidase domain protein glpCD - - - - - - - - - - - CCG,DUF3400,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_8 k59_1005837_1 1411123.JQNH01000001_gene742 7.27e-100 302.0 COG0074@1|root,COG0074@2|Bacteria,1MX67@1224|Proteobacteria,2U0AT@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Protein of unknown function (DUF1116) - - - - - - - - - - - - DUF1116 k59_1130537_1 638303.Thal_0032 1.75e-46 161.0 COG0037@1|root,COG0037@2|Bacteria 2|Bacteria D tRNA processing tilS - 2.8.1.15,6.3.4.19 ko:K04075,ko:K21947 - - R09597 RC02633,RC02634 ko00000,ko01000,ko03016 - - - ATP_bind_3,TilS_C k59_1176686_1 1051632.TPY_0690 2.79e-06 50.8 COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,247RK@186801|Clostridia,3WCJ4@538999|Clostridiales incertae sedis 186801|Clostridia I PFAM Enoyl-CoA hydratase isomerase family - - 4.2.1.17 ko:K01692,ko:K01715 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_1303956_1 1175306.GWL_46150 2.33e-57 199.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,2VJ57@28216|Betaproteobacteria,4724B@75682|Oxalobacteraceae 28216|Betaproteobacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_1351372_1 1333998.M2A_2932 1.6e-14 72.8 COG1167@1|root,COG1167@2|Bacteria,1MUJE@1224|Proteobacteria,2TQZZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs - - - - - - - - - - - - Aminotran_1_2,GntR k59_1351372_2 1123278.KB893549_gene5154 3.39e-31 119.0 COG0384@1|root,COG0384@2|Bacteria,4NEWM@976|Bacteroidetes,47JVW@768503|Cytophagia 976|Bacteroidetes S phenazine biosynthesis protein PhzF family - - - - - - - - - - - - PhzC-PhzF k59_196152_1 261292.Nit79A3_1727 1.82e-86 266.0 COG2203@1|root,COG3437@1|root,COG2203@2|Bacteria,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,2VH1F@28216|Betaproteobacteria,372TF@32003|Nitrosomonadales 28216|Betaproteobacteria KT PFAM Metal-dependent phosphohydrolase, HD - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CHASE2,GAF_2,HD k59_797088_1 1095769.CAHF01000001_gene3532 5.53e-93 277.0 COG1881@1|root,COG1881@2|Bacteria,1N0Y4@1224|Proteobacteria,2VJ4C@28216|Betaproteobacteria,473B4@75682|Oxalobacteraceae 28216|Betaproteobacteria S Phosphatidylethanolamine-binding protein bbsI - - ko:K06910 - - - - ko00000 - - - PBP k59_797088_2 296591.Bpro_0913 1.89e-17 84.3 COG0421@1|root,COG0421@2|Bacteria,1RBWW@1224|Proteobacteria,2VQ5B@28216|Betaproteobacteria 28216|Betaproteobacteria H Spermidine synthase speE2 - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synth k59_77825_1 1144275.COCOR_03218 7.51e-14 75.9 COG0564@1|root,COG0564@2|Bacteria,1MUBN@1224|Proteobacteria,42MBA@68525|delta/epsilon subdivisions,2WKX9@28221|Deltaproteobacteria,2YUWE@29|Myxococcales 28221|Deltaproteobacteria J Responsible for synthesis of pseudouridine from uracil rluD3 - 5.4.99.23 ko:K06180 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_1309600_1 1268622.AVS7_00087 2.09e-39 141.0 COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,2VKQ0@28216|Betaproteobacteria,4ACTU@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM Transketolase central region - - 1.2.4.1 ko:K00162,ko:K21417 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C k59_1309600_2 1394178.AWOO02000026_gene5130 1.67e-11 65.1 2DBA3@1|root,2Z80R@2|Bacteria,2GXJC@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_633841_1 350054.Mflv_0988 1.49e-93 289.0 COG0069@1|root,COG0069@2|Bacteria,2GME2@201174|Actinobacteria,23619@1762|Mycobacteriaceae 201174|Actinobacteria E Belongs to the glutamate synthase family gltB_1 - - - - - - - - - - - Glu_synthase k59_542234_1 1268622.AVS7_00334 7.19e-19 87.4 COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,2VHRH@28216|Betaproteobacteria 28216|Betaproteobacteria C Cytochrome c oxidase accessory protein ccog ccoG - - - - - - - - - - - Fer4_18,Fer4_5,FixG_C k59_542234_2 1454004.AW11_01642 1.55e-18 81.6 COG3198@1|root,COG3198@2|Bacteria,1N75J@1224|Proteobacteria,2VTYE@28216|Betaproteobacteria 28216|Betaproteobacteria S FixH - - - ko:K09926 - - - - ko00000 - - - FixH k59_755361_1 760117.JN27_12055 2e-51 171.0 COG1058@1|root,COG1058@2|Bacteria,1MVG6@1224|Proteobacteria,2VHTD@28216|Betaproteobacteria,472Z6@75682|Oxalobacteraceae 28216|Betaproteobacteria S Probable molybdopterin binding domain yfaY - - - - - - - - - - - MoCF_biosynth k59_542257_2 1445613.JALM01000042_gene1754 1.48e-20 90.9 COG1024@1|root,COG1024@2|Bacteria,2HDCI@201174|Actinobacteria,4E3KX@85010|Pseudonocardiales 201174|Actinobacteria I Enoyl-CoA hydratase/isomerase - - - - - - - - - - - - ECH_1 k59_375886_1 1033730.CAHG01000015_gene807 2.38e-24 97.4 COG0745@1|root,COG0745@2|Bacteria,2GMVN@201174|Actinobacteria,4DT9H@85009|Propionibacteriales 201174|Actinobacteria T Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Response_reg,Trans_reg_C k59_375886_2 2002.JOEQ01000047_gene7233 4.66e-24 105.0 COG0642@1|root,COG0642@2|Bacteria,2GMHQ@201174|Actinobacteria,4EFMH@85012|Streptosporangiales 201174|Actinobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_332584_1 1207063.P24_12896 2.01e-74 225.0 COG0203@1|root,COG0203@2|Bacteria,1RCWN@1224|Proteobacteria,2U749@28211|Alphaproteobacteria,2JS6K@204441|Rhodospirillales 204441|Rhodospirillales J structural constituent of ribosome rplQ - - ko:K02879 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L17 k59_1181783_1 261292.Nit79A3_3175 1.87e-73 234.0 COG2379@1|root,COG2379@2|Bacteria,1MVIK@1224|Proteobacteria,2VHXK@28216|Betaproteobacteria,371WQ@32003|Nitrosomonadales 28216|Betaproteobacteria C MOFRL family ttuD2 - 2.7.1.165 ko:K11529 ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200 M00346 R08572 RC00002,RC00428 ko00000,ko00001,ko00002,ko01000 - - - DUF4147,MOFRL k59_1267132_1 438753.AZC_0490 2.01e-84 261.0 COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,2TR1J@28211|Alphaproteobacteria,3EYMA@335928|Xanthobacteraceae 28211|Alphaproteobacteria C Zinc-binding dehydrogenase MA20_18095 - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_1060549_1 228410.NE1756 1.68e-50 162.0 COG1981@1|root,COG1981@2|Bacteria,1RHGS@1224|Proteobacteria,2VR5Y@28216|Betaproteobacteria,3737C@32003|Nitrosomonadales 28216|Betaproteobacteria S Uncharacterised protein family (UPF0093) - - - ko:K08973 - - - - ko00000 - - - UPF0093 k59_1060549_2 159450.NH14_12395 5.65e-38 140.0 COG0116@1|root,COG0116@2|Bacteria,1MUQM@1224|Proteobacteria,2VHMY@28216|Betaproteobacteria,1K0NW@119060|Burkholderiaceae 28216|Betaproteobacteria L Belongs to the methyltransferase superfamily rlmL - - ko:K07444 - - - - ko00000,ko01000 - - - THUMP,UPF0020 k59_201227_1 1123393.KB891327_gene345 5.99e-90 276.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,2VJ6T@28216|Betaproteobacteria,1KT09@119069|Hydrogenophilales 119069|Hydrogenophilales C Cysteine-rich domain - - - - - - - - - - - - CCG k59_542348_1 1265313.HRUBRA_01402 2.66e-74 251.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1J55M@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Glutamate synthase domain gltB GO:0003674,GO:0003824,GO:0004355,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045181,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - iBWG_1329.BWG_2914,iECDH10B_1368.ECDH10B_3387,iECDH1ME8569_1439.EcDH1_0495,iEcDH1_1363.EcDH1_0495,iPC815.YPO3557 GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_415233_1 570967.JMLV01000002_gene1982 5.7e-55 180.0 COG0235@1|root,COG0235@2|Bacteria,1MWP9@1224|Proteobacteria,2TRMV@28211|Alphaproteobacteria,2JRJV@204441|Rhodospirillales 204441|Rhodospirillales G COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases - - - - - - - - - - - - Aldolase_II k59_582683_1 887898.HMPREF0551_1896 3.48e-40 135.0 COG0198@1|root,COG0198@2|Bacteria,1MZQD@1224|Proteobacteria,2VUC6@28216|Betaproteobacteria,1K8C0@119060|Burkholderiaceae 28216|Betaproteobacteria J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit rplX - - ko:K02895 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KOW,ribosomal_L24 k59_582683_2 1335757.SPICUR_08235 2.18e-69 211.0 COG0093@1|root,COG0093@2|Bacteria,1RCWZ@1224|Proteobacteria,1S3Z3@1236|Gammaproteobacteria,1WY84@135613|Chromatiales 135613|Chromatiales J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome rplN - - ko:K02874 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L14 k59_582683_3 283942.IL1915 2.93e-31 112.0 COG0186@1|root,COG0186@2|Bacteria,1MZIK@1224|Proteobacteria,1S8SS@1236|Gammaproteobacteria,2QGC7@267893|Idiomarinaceae 1236|Gammaproteobacteria J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA rpsQ GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046677,GO:0050896,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02961 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S17 k59_78009_1 827.JFJK01000005_gene1249 4.38e-31 125.0 COG0607@1|root,COG2864@1|root,COG0607@2|Bacteria,COG2864@2|Bacteria,1NJEJ@1224|Proteobacteria,42NQM@68525|delta/epsilon subdivisions,2YNHB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria CP Rhodanese Homology Domain - - - - - - - - - - - - Rhodanese k59_879670_1 1121861.KB899923_gene3403 2.22e-59 195.0 COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,2TRQA@28211|Alphaproteobacteria,2JPTV@204441|Rhodospirillales 204441|Rhodospirillales J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH - 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 k59_712989_1 404380.Gbem_0064 6.07e-51 174.0 COG0845@1|root,COG0845@2|Bacteria,1MW65@1224|Proteobacteria,42NJG@68525|delta/epsilon subdivisions,2WJ8R@28221|Deltaproteobacteria,43US6@69541|Desulfuromonadales 28221|Deltaproteobacteria M Biotin-lipoyl like - - - ko:K07799 ko02020,map02020 M00648 - - ko00000,ko00001,ko00002,ko02000 8.A.1 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_332739_1 1101195.Meth11DRAFT_0961 3.44e-52 175.0 COG0287@1|root,COG0287@2|Bacteria,1QTZA@1224|Proteobacteria,2VIS1@28216|Betaproteobacteria,2KKEM@206350|Nitrosomonadales 206350|Nitrosomonadales E PFAM Prephenate dehydrogenase - - 1.3.1.12 ko:K04517 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00025 R01728 RC00125 ko00000,ko00001,ko00002,ko01000 - - - PDH k59_332739_2 272952.HpaP811645 1.46e-10 62.0 COG0169@1|root,KOG0692@2759|Eukaryota,3Q7F3@4776|Peronosporales 4776|Peronosporales E The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis - - 1.1.1.25,2.5.1.19,2.7.1.71,4.2.1.10,4.2.3.4 ko:K13830 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412,R02413,R03083,R03084,R03460 RC00002,RC00078,RC00206,RC00350,RC00847,RC00848 ko00000,ko00001,ko00002,ko01000 - - - DHQ_synthase,DHquinase_I,EPSP_synthase,SKI,Shikimate_DH,Shikimate_dh_N k59_415295_1 1380355.JNIJ01000001_gene3989 2.45e-117 341.0 COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2TR61@28211|Alphaproteobacteria,3JU16@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E ATPases associated with a variety of cellular activities - - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_114025_1 1122236.KB905143_gene239 4.6e-05 45.4 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,2KKZR@206350|Nitrosomonadales 206350|Nitrosomonadales NU General secretory system II protein E domain protein - - - ko:K02454,ko:K02652 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSE,T2SSE_N k59_114025_2 159087.Daro_3408 3.48e-57 190.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,2VI1J@28216|Betaproteobacteria,2KU71@206389|Rhodocyclales 206389|Rhodocyclales NU type II secretion system protein - - - ko:K02653 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSF k59_1060701_1 497321.C664_10972 6.61e-122 375.0 COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,2VJ5Q@28216|Betaproteobacteria,2KV41@206389|Rhodocyclales 206389|Rhodocyclales L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k59_542437_1 709797.CSIRO_2140 4.82e-29 120.0 COG0477@1|root,COG2814@2|Bacteria,1P4XF@1224|Proteobacteria,2U185@28211|Alphaproteobacteria,3JT15@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_78071_1 1120960.ATXG01000011_gene3561 5.52e-26 111.0 COG0664@1|root,COG0664@2|Bacteria,2I8MP@201174|Actinobacteria,4FQMK@85023|Microbacteriaceae 201174|Actinobacteria T Cyclic nucleotide-monophosphate binding domain - - - - - - - - - - - - MFS_1,cNMP_binding k59_671054_1 1502852.FG94_03247 1.34e-69 230.0 COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,2VHHZ@28216|Betaproteobacteria,473Z4@75682|Oxalobacteraceae 28216|Betaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_671054_2 1260251.SPISAL_05255 1.18e-32 124.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RPAB@1236|Gammaproteobacteria,1WVW1@135613|Chromatiales 135613|Chromatiales C 4Fe-4S ferredoxin iron-sulfur binding domain protein glcF - - ko:K11473 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - CCG,Fer4_7,Fer4_8 k59_755581_1 204669.Acid345_1213 1.62e-47 162.0 COG1024@1|root,COG1024@2|Bacteria,3Y47B@57723|Acidobacteria,2JIRS@204432|Acidobacteriia 204432|Acidobacteriia I Enoyl-CoA hydratase/isomerase - - 4.2.1.17 ko:K01715 ko00650,ko01200,map00650,map01200 - R03026 RC00831 ko00000,ko00001,ko01000 - - - ECH_1 k59_968678_1 1157637.KB892124_gene678 7.17e-33 131.0 COG1167@1|root,COG1167@2|Bacteria,2GNFG@201174|Actinobacteria 201174|Actinobacteria K COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs - - - - - - - - - - - - Aminotran_1_2,GntR k59_415357_1 399739.Pmen_3543 6.69e-28 110.0 COG2890@1|root,COG2890@2|Bacteria,1MY5I@1224|Proteobacteria,1T26C@1236|Gammaproteobacteria,1YM01@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria J O-methyltransferase - - - - - - - - - - - - Methyltransf_31,PrmA k59_415357_2 1485544.JQKP01000015_gene2058 2.07e-16 79.7 COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,2VIGF@28216|Betaproteobacteria,44VNW@713636|Nitrosomonadales 28216|Betaproteobacteria L DHH family recJ - - ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 k59_457376_1 1192124.LIG30_3914 2.68e-17 84.3 COG2067@1|root,COG2067@2|Bacteria,1N1F4@1224|Proteobacteria,2VW9Z@28216|Betaproteobacteria,1K5MQ@119060|Burkholderiaceae 28216|Betaproteobacteria I long-chain fatty acid transport protein - - - - - - - - - - - - Phenol_MetA_deg k59_999672_1 1121035.AUCH01000016_gene2125 1.01e-17 83.2 COG2010@1|root,COG3391@1|root,COG2010@2|Bacteria,COG3391@2|Bacteria,1PYK3@1224|Proteobacteria,2VIU7@28216|Betaproteobacteria,2KU6N@206389|Rhodocyclales 206389|Rhodocyclales C cytochrome nirN - - - - - - - - - - - Cytochrom_D1,Cytochrome_CBB3 k59_999672_2 713586.KB900536_gene2310 1.44e-56 186.0 COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,1RMR1@1236|Gammaproteobacteria,1WWJ4@135613|Chromatiales 135613|Chromatiales S Radical SAM superfamily pqqE - - ko:K06139 - - - - ko00000 - - - Fer4_12,Fer4_14,Radical_SAM,SPASM k59_445761_1 1380394.JADL01000025_gene76 2.47e-100 323.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,2TS7S@28211|Alphaproteobacteria,2JQ0Q@204441|Rhodospirillales 204441|Rhodospirillales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_145032_1 1333998.M2A_0511 8.11e-94 298.0 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,2TS9E@28211|Alphaproteobacteria,4BPCE@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_1125050_1 1042163.BRLA_c009940 7.9e-39 143.0 COG0697@1|root,COG0697@2|Bacteria,1UZGC@1239|Firmicutes,4HDET@91061|Bacilli,26U8N@186822|Paenibacillaceae 91061|Bacilli EG EamA-like transporter family yrdR - - - - - - - - - - - EamA k59_145047_2 420662.Mpe_A0647 2.68e-46 163.0 COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,2VHM5@28216|Betaproteobacteria,1KJPB@119065|unclassified Burkholderiales 28216|Betaproteobacteria J Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner lepA - - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C k59_1344981_1 748247.AZKH_3554 5.55e-21 84.7 COG0776@1|root,COG0776@2|Bacteria,1MZ7M@1224|Proteobacteria,2VSPN@28216|Betaproteobacteria,2KWNF@206389|Rhodocyclales 206389|Rhodocyclales K This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control ihfB - - ko:K05788 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding k59_1344981_2 1485544.JQKP01000011_gene760 1.97e-14 70.1 COG5416@1|root,COG5416@2|Bacteria,1N4UI@1224|Proteobacteria,2VU63@28216|Betaproteobacteria,44W2U@713636|Nitrosomonadales 28216|Betaproteobacteria S Pfam:DUF1049 - - - ko:K08992 - - - - ko00000 - - - LapA_dom k59_1170458_1 107636.JQNK01000009_gene3513 3e-102 310.0 COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2TRXG@28211|Alphaproteobacteria,370BU@31993|Methylocystaceae 28211|Alphaproteobacteria L Transposase DDE domain - - - ko:K07487 - - - - ko00000 - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_21568_1 1242864.D187_005224 5.65e-47 167.0 COG2843@1|root,COG2843@2|Bacteria,1Q4SV@1224|Proteobacteria,42ZT3@68525|delta/epsilon subdivisions,2WV46@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Bacterial capsule synthesis protein PGA_cap - - - - - - - - - - - - PGA_cap k59_145055_1 296591.Bpro_0610 1.53e-84 275.0 COG3188@1|root,COG3188@2|Bacteria,1MWV6@1224|Proteobacteria,2VIR3@28216|Betaproteobacteria,4AD84@80864|Comamonadaceae 28216|Betaproteobacteria NU Outer membrane usher protein - - - ko:K07347 ko05133,map05133 - - - ko00000,ko00001,ko02000,ko02035,ko02044 1.B.11.3 - - PapC_C,Usher k59_620768_1 69279.BG36_16370 1.71e-05 45.8 COG0346@1|root,COG0346@2|Bacteria,1R8DA@1224|Proteobacteria,2TTKJ@28211|Alphaproteobacteria,43ME6@69277|Phyllobacteriaceae 28211|Alphaproteobacteria E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - 5.1.3.33 ko:K20431 ko00525,ko01130,map00525,map01130 M00815 R11079 RC01519 ko00000,ko00001,ko00002,ko01000 - - - Glyoxalase,Glyoxalase_4 k59_620768_2 543728.Vapar_1858 2.51e-56 186.0 COG0673@1|root,COG0673@2|Bacteria,1PYTN@1224|Proteobacteria,2VKKE@28216|Betaproteobacteria,4AA47@80864|Comamonadaceae 28216|Betaproteobacteria S Oxidoreductase domain protein - - - - - - - - - - - - GFO_IDH_MocA k59_1297466_1 671143.DAMO_2946 2.11e-86 277.0 COG0187@1|root,COG0187@2|Bacteria,2NNSN@2323|unclassified Bacteria 2|Bacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009330,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0032991,GO:0034335,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:0140097,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_957256_1 1121948.AUAC01000003_gene2507 1.48e-57 200.0 COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2TQVK@28211|Alphaproteobacteria,43WFJ@69657|Hyphomonadaceae 28211|Alphaproteobacteria C COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL homologs iorB - 1.3.99.16 ko:K07303 - - - - ko00000,ko01000 - - - Ald_Xan_dh_C2 k59_957256_2 391165.GbCGDNIH1_0793 2.72e-22 91.7 COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,2U6Z6@28211|Alphaproteobacteria,2JSHT@204441|Rhodospirillales 204441|Rhodospirillales C [2Fe-2S] binding domain - - - - - - - - - - - - Fer2,Fer2_2 k59_701706_1 196367.JNFG01000052_gene1499 2.57e-95 288.0 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,2VHJZ@28216|Betaproteobacteria,1K1TX@119060|Burkholderiaceae 28216|Betaproteobacteria C Belongs to the citrate synthase family prpC - 2.3.3.5 ko:K01659 ko00640,map00640 - R00931 RC00004,RC00406,RC02827 ko00000,ko00001,ko01000 - - - Citrate_synt k59_364646_1 1502852.FG94_00954 9.3e-46 168.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VJMN@28216|Betaproteobacteria,476HZ@75682|Oxalobacteraceae 28216|Betaproteobacteria T 7TM diverse intracellular signalling - - - - - - - - - - - - 7TMR-DISM_7TM,EAL,GGDEF,HAMP,PAS,PAS_4,PAS_8,PAS_9,dCache_3 k59_145136_1 404589.Anae109_3668 2.11e-44 159.0 COG2197@1|root,COG2197@2|Bacteria,1R03J@1224|Proteobacteria 1224|Proteobacteria K helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE k59_919348_1 760117.JN27_19035 2.14e-35 133.0 COG4324@1|root,COG4324@2|Bacteria,1N0FE@1224|Proteobacteria,2VH73@28216|Betaproteobacteria,476PV@75682|Oxalobacteraceae 28216|Betaproteobacteria S Putative aminopeptidase - - - - - - - - - - - - Aminopep k59_535604_1 1120999.JONM01000010_gene4185 8.71e-61 193.0 COG0703@1|root,COG0703@2|Bacteria,1MUFJ@1224|Proteobacteria,2VRDN@28216|Betaproteobacteria,2KR45@206351|Neisseriales 206351|Neisseriales F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate aroK - 2.7.1.71 ko:K00891 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - SKI k59_535604_2 713587.THITH_14925 6.09e-10 60.1 COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,1RN4I@1236|Gammaproteobacteria,1WWZW@135613|Chromatiales 135613|Chromatiales E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) aroB - 4.2.3.4 ko:K01735 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03083 RC00847 ko00000,ko00001,ko00002,ko01000 - - - DHQ_synthase k59_1349750_1 196162.Noca_3775 2.02e-29 115.0 COG1136@1|root,COG1136@2|Bacteria,2GM25@201174|Actinobacteria 201174|Actinobacteria V ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1349750_2 1397527.Q670_11080 1.38e-11 66.2 COG2834@1|root,COG2834@2|Bacteria,1MXW0@1224|Proteobacteria,1RS0K@1236|Gammaproteobacteria,1XHXM@135619|Oceanospirillales 135619|Oceanospirillales M Outer membrane lipoprotein-sorting protein - - - - - - - - - - - - LolA_like k59_1217757_1 672.VV93_v1c09190 1.95e-25 100.0 COG2905@1|root,COG2905@2|Bacteria,1MZGY@1224|Proteobacteria,1S86K@1236|Gammaproteobacteria,1XXFK@135623|Vibrionales 135623|Vibrionales T COG0517 FOG CBS domain - - - - - - - - - - - - CBS k59_1217757_2 493475.GARC_5061 3.41e-22 90.5 COG0662@1|root,COG0662@2|Bacteria,1NCNA@1224|Proteobacteria,1SQXI@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Cupin - - - - - - - - - - - - Cupin_2 k59_1129092_2 1174684.EBMC1_12205 1.52e-72 227.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,2K2SD@204457|Sphingomonadales 204457|Sphingomonadales L Transposase - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_236997_1 1131814.JAFO01000001_gene4403 3.19e-17 85.9 COG0500@1|root,COG2226@2|Bacteria,1MXP4@1224|Proteobacteria,2TQU4@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q ubiE/COQ5 methyltransferase family - - - - - - - - - - - - Methyltransf_11 k59_1260432_1 76114.ebA1021 9.17e-122 372.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,2VH6Z@28216|Betaproteobacteria,2KVJ1@206389|Rhodocyclales 206389|Rhodocyclales J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_277543_1 1229780.BN381_130392 4.88e-48 169.0 COG1486@1|root,COG1486@2|Bacteria,2GK80@201174|Actinobacteria,3UXQV@52018|unclassified Actinobacteria (class) 201174|Actinobacteria G Family 4 glycosyl hydrolase malH - 3.2.1.22 ko:K07406 ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603 - R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091 RC00049,RC00059,RC00451 ko00000,ko00001,ko01000 - - - Glyco_hydro_4,Glyco_hydro_4C k59_237020_3 1134474.O59_003943 7.6e-10 62.0 COG4275@1|root,COG4275@2|Bacteria,1MYDE@1224|Proteobacteria,1RPIV@1236|Gammaproteobacteria,1FI1M@10|Cellvibrio 1236|Gammaproteobacteria S Chromate resistance exported protein - - - - - - - - - - - - Chrome_Resist k59_1095002_1 1283300.ATXB01000002_gene2925 1.95e-24 101.0 COG0398@1|root,COG1249@1|root,COG0398@2|Bacteria,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RQTU@1236|Gammaproteobacteria,1XE1B@135618|Methylococcales 135618|Methylococcales C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family - - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim,SNARE_assoc k59_1095002_2 395495.Lcho_1708 2.41e-84 258.0 COG0398@1|root,COG0398@2|Bacteria,1RBAE@1224|Proteobacteria,2VP38@28216|Betaproteobacteria,1KN8D@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Protein of unknown function, DUF547 - - - - - - - - - - - - DUF547 k59_194560_2 1095769.CAHF01000022_gene40 5.96e-83 253.0 COG5424@1|root,COG5424@2|Bacteria,1QVK0@1224|Proteobacteria 1224|Proteobacteria H Iron-containing redox enzyme - - - - - - - - - - - - Haem_oxygenas_2 k59_369288_1 864051.BurJ1DRAFT_3341 9.21e-65 209.0 COG2175@1|root,COG2175@2|Bacteria,1R5KS@1224|Proteobacteria,2VIG6@28216|Betaproteobacteria 28216|Betaproteobacteria Q Taurine catabolism dioxygenase TauD, TfdA family - - - - - - - - - - - - TauD k59_194570_1 1144319.PMI16_05067 8.58e-06 52.4 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria,476XE@75682|Oxalobacteraceae 28216|Betaproteobacteria NT methyl-accepting chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal,TarH,sCache_2 k59_1349841_1 1005048.CFU_4391 3.31e-47 154.0 COG0355@1|root,COG0355@2|Bacteria,1RHE4@1224|Proteobacteria,2VR2R@28216|Betaproteobacteria,474C5@75682|Oxalobacteraceae 28216|Betaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane atpC - - ko:K02114 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_DE,ATP-synt_DE_N k59_1349841_2 1437824.BN940_17346 2.18e-34 129.0 COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,2VHDZ@28216|Betaproteobacteria,3T1NI@506|Alcaligenaceae 28216|Betaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N k59_369365_2 426117.M446_2884 1.58e-23 104.0 COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2U9HC@28211|Alphaproteobacteria 28211|Alphaproteobacteria S ABC transporter substrate binding protein - - - ko:K01989 - M00247 - - ko00000,ko00002,ko02000 - - - ABC_sub_bind k59_535764_1 398527.Bphyt_6362 9.89e-52 174.0 COG0010@1|root,COG0010@2|Bacteria,1MVFH@1224|Proteobacteria,2VJU2@28216|Betaproteobacteria,1KGZF@119060|Burkholderiaceae 28216|Betaproteobacteria E Belongs to the arginase family rocF - 3.5.3.1,3.5.3.17,3.5.3.7 ko:K01476,ko:K12255,ko:K18459 ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146 M00029,M00134 R00551,R01990 RC00024,RC00329 ko00000,ko00001,ko00002,ko01000 - - - Arginase k59_1095118_1 1379698.RBG1_1C00001G0516 4.42e-87 267.0 COG0473@1|root,COG0473@2|Bacteria,2NP1R@2323|unclassified Bacteria 2|Bacteria CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate leuB GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0040007,GO:0044424,GO:0044464,GO:0055114 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_1175167_1 765911.Thivi_0551 4.38e-86 268.0 COG0247@1|root,COG0247@2|Bacteria,1NZIG@1224|Proteobacteria,1RYPW@1236|Gammaproteobacteria,1WXQI@135613|Chromatiales 135613|Chromatiales C 4Fe-4S dicluster domain - - - - - - - - - - - - CCG,Fer4_17,Fer4_8 k59_1175167_2 413404.Rmag_0864 1.98e-14 71.6 COG2181@1|root,COG2181@2|Bacteria,1R48S@1224|Proteobacteria,1RYZ2@1236|Gammaproteobacteria 1236|Gammaproteobacteria C PFAM Nitrate reductase gamma subunit dsrM - - - - - - - - - - - Nitrate_red_gam k59_277688_1 272560.BPSS1833 6.46e-87 270.0 COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,2VGZI@28216|Betaproteobacteria,1K30S@119060|Burkholderiaceae 28216|Betaproteobacteria C Belongs to the UDP-glucose GDP-mannose dehydrogenase family ugd - 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_1217927_1 665571.STHERM_c03630 1.74e-81 244.0 COG0432@1|root,COG0432@2|Bacteria,2J7PN@203691|Spirochaetes 203691|Spirochaetes S Secondary thiamine-phosphate synthase enzyme - - - - - - - - - - - - UPF0047 k59_961936_1 1144342.PMI40_00566 7.11e-25 102.0 COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,2VH1Q@28216|Betaproteobacteria,473PQ@75682|Oxalobacteraceae 28216|Betaproteobacteria C Aldo/keto reductase family yakC - - - - - - - - - - - Aldo_ket_red k59_961936_2 1385517.N800_06100 2.64e-21 89.4 COG3917@1|root,COG3917@2|Bacteria,1MWB9@1224|Proteobacteria,1S4K8@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q 2-hydroxychromene-2-carboxylate isomerase - - 5.99.1.4 ko:K14584 ko00626,ko01100,ko01120,ko01220,map00626,map01100,map01120,map01220 M00534 R05137 RC03084 br01602,ko00000,ko00001,ko00002,ko01000 - - - DSBA k59_830787_1 509191.AEDB02000043_gene4765 9.52e-53 174.0 COG0517@1|root,COG0517@2|Bacteria,1TQ4J@1239|Firmicutes,24B68@186801|Clostridia,3WQ1J@541000|Ruminococcaceae 186801|Clostridia S Putative transposase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_535805_1 1276756.AUEX01000004_gene2352 4.85e-107 334.0 COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2VI9R@28216|Betaproteobacteria,4AAAJ@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM CoA-binding domain protein - - - - - - - - - - - - ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,Acetyltransf_4,CoA_binding_2,Succ_CoA_lig k59_237223_1 1205680.CAKO01000040_gene1071 4.81e-58 199.0 COG0559@1|root,COG4177@1|root,COG0559@2|Bacteria,COG4177@2|Bacteria,1MY1E@1224|Proteobacteria,2TTC6@28211|Alphaproteobacteria,2JQDN@204441|Rhodospirillales 204441|Rhodospirillales E Branched-chain amino acid transport system / permease component - - - ko:K01997,ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_1349973_1 1114179.I2FLT8_9CAUD 1.54e-16 84.7 4QAUF@10239|Viruses,4QWIQ@35237|dsDNA viruses no RNA stage,4QUFS@28883|Caudovirales,4QNVK@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_277777_1 864051.BurJ1DRAFT_3225 9.73e-147 433.0 COG1600@1|root,COG1600@2|Bacteria,1QZV5@1224|Proteobacteria 1224|Proteobacteria C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) - - - - - - - - - - - - Dehalogenase k59_795682_1 1082933.MEA186_30901 2.22e-48 176.0 COG1572@1|root,COG2931@1|root,COG3210@1|root,COG4070@1|root,COG1572@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4070@2|Bacteria,1MU7T@1224|Proteobacteria 1224|Proteobacteria Q COG2931, RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - Autotransporter,Cadherin-like,Calx-beta,DUF4347,He_PIG k59_1260675_1 1100720.ALKN01000028_gene2480 3.34e-116 348.0 COG0183@1|root,COG1545@1|root,COG0183@2|Bacteria,COG1545@2|Bacteria,1MUZV@1224|Proteobacteria,2VNPV@28216|Betaproteobacteria,4ABDT@80864|Comamonadaceae 28216|Betaproteobacteria I thiolase - - - - - - - - - - - - Thiolase_C k59_1260675_2 1380394.JADL01000008_gene3458 3.14e-18 82.0 COG0235@1|root,COG0235@2|Bacteria,1MWP9@1224|Proteobacteria,2TRMV@28211|Alphaproteobacteria,2JRJV@204441|Rhodospirillales 204441|Rhodospirillales G COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases - - - - - - - - - - - - Aldolase_II k59_1218017_1 1047013.AQSP01000140_gene2472 3.61e-62 204.0 COG0849@1|root,COG0849@2|Bacteria,2NNU2@2323|unclassified Bacteria 2|Bacteria D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring ftsA GO:0000166,GO:0003674,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008144,GO:0008150,GO:0009898,GO:0009987,GO:0016020,GO:0017076,GO:0030554,GO:0032153,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0051301,GO:0071944,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363 - ko:K03590 ko04112,map04112 - - - ko00000,ko00001,ko03036,ko04812 - - - FtsA,SHS2_FTSA k59_149742_1 1265313.HRUBRA_02487 8.96e-83 254.0 COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,1RMU3@1236|Gammaproteobacteria,1J4UB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA GO:0003674,GO:0003824,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L k59_1095275_1 391937.NA2_14332 3.61e-83 254.0 COG0235@1|root,COG0235@2|Bacteria,1MWP9@1224|Proteobacteria,2TRMV@28211|Alphaproteobacteria 28211|Alphaproteobacteria G COG0235, Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases - - - - - - - - - - - - Aldolase_II k59_1095275_2 991905.SL003B_2967 2.23e-09 57.8 COG2271@1|root,COG2271@2|Bacteria,1QVY6@1224|Proteobacteria,2TVPK@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Major Facilitator Superfamily MA20_09740 - - - - - - - - - - - MFS_1 k59_369510_1 439235.Dalk_3539 7.45e-34 123.0 COG0223@1|root,COG0223@2|Bacteria,1Q7FH@1224|Proteobacteria,430U1@68525|delta/epsilon subdivisions,2WVN7@28221|Deltaproteobacteria 28221|Deltaproteobacteria H PFAM Formyl transferase - - 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - - Formyl_trans_N k59_962051_1 323848.Nmul_A2005 1.33e-136 410.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2VH8J@28216|Betaproteobacteria,371XZ@32003|Nitrosomonadales 28216|Betaproteobacteria P TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC copF - 3.6.3.4,3.6.3.54 ko:K01533,ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,Hydrolase,YHS k59_237329_1 203122.Sde_1225 6.57e-80 246.0 COG0705@1|root,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,1RZ5Q@1236|Gammaproteobacteria,46767@72275|Alteromonadaceae 1236|Gammaproteobacteria S membrane protein (homolog of Drosophila rhomboid) - - - - - - - - - - - - Rhomboid k59_919694_1 366394.Smed_0777 8.71e-13 65.5 COG5516@1|root,COG5516@2|Bacteria,1N7M4@1224|Proteobacteria,2TT60@28211|Alphaproteobacteria,4BAYY@82115|Rhizobiaceae 28211|Alphaproteobacteria S Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding - - - - - - - - - - - - ABATE,zf-CGNR k59_919694_2 641524.ADICYQ_4936 5.28e-22 101.0 COG0334@1|root,COG0334@2|Bacteria,4NG6Y@976|Bacteroidetes,47KWD@768503|Cytophagia 976|Bacteroidetes E Glu Leu Phe Val dehydrogenase - - 1.4.1.3 ko:K00261 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_1302677_1 886293.Sinac_5423 7.47e-66 225.0 COG0046@1|root,COG1828@1|root,COG0046@2|Bacteria,COG1828@2|Bacteria,2IXRT@203682|Planctomycetes 203682|Planctomycetes F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purL - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C,PurS k59_450765_1 1380394.JADL01000003_gene5165 4.88e-44 157.0 COG1024@1|root,COG1024@2|Bacteria,1N817@1224|Proteobacteria,2TQTE@28211|Alphaproteobacteria 28211|Alphaproteobacteria I enoyl-CoA hydratase boxC - 4.1.2.44 ko:K15513 ko00362,map00362 - R09556 RC03426 ko00000,ko00001,ko01000 - - - ECH_1 k59_450765_2 391038.Bphy_1539 1.87e-21 92.8 COG3396@1|root,COG3396@2|Bacteria,1MXUK@1224|Proteobacteria,2VH89@28216|Betaproteobacteria,1K485@119060|Burkholderiaceae 28216|Betaproteobacteria S benzoyl-CoA oxygenase boxB - 1.14.13.208 ko:K15512 ko00362,map00362 - R09555 RC01739 ko00000,ko00001,ko01000 - - - - k59_149832_2 1380394.JADL01000011_gene3800 6.26e-27 112.0 2DMUX@1|root,32TU3@2|Bacteria,1RB0V@1224|Proteobacteria,2U5CJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF2877) - - - - - - - - - - - - DUF2877 k59_749132_2 1041138.KB890253_gene4087 1.17e-27 107.0 COG1917@1|root,COG1917@2|Bacteria,1PUJA@1224|Proteobacteria,2V66B@28211|Alphaproteobacteria,4BJII@82115|Rhizobiaceae 28211|Alphaproteobacteria S Cupin 2, conserved barrel domain protein - - - - - - - - - - - - - k59_1218136_1 1158292.JPOE01000002_gene2250 4.43e-37 134.0 COG0500@1|root,COG2226@2|Bacteria,1NRR4@1224|Proteobacteria,2W05F@28216|Betaproteobacteria 28216|Betaproteobacteria Q ubiE/COQ5 methyltransferase family - - 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Ubie_methyltran k59_576245_1 1380394.JADL01000002_gene1158 1.84e-64 206.0 COG4177@1|root,COG4177@2|Bacteria,1P0DF@1224|Proteobacteria,2TUBF@28211|Alphaproteobacteria,2JUXE@204441|Rhodospirillales 204441|Rhodospirillales E Branched-chain amino acid transport system / permease component - - - - - - - - - - - - BPD_transp_2 k59_576245_2 1380394.JADL01000002_gene1159 5.26e-77 238.0 COG0559@1|root,COG0559@2|Bacteria,1MXGK@1224|Proteobacteria,2TVKT@28211|Alphaproteobacteria,2JVW1@204441|Rhodospirillales 204441|Rhodospirillales E Branched-chain amino acid transport system / permease component - - - - - - - - - - - - BPD_transp_2 k59_962175_1 479434.Sthe_0538 6.37e-16 80.5 COG0183@1|root,COG0183@2|Bacteria,2G63J@200795|Chloroflexi 200795|Chloroflexi I Belongs to the thiolase family - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_962175_2 1532557.JL37_03675 3.42e-12 63.2 COG1545@1|root,COG1545@2|Bacteria,1N2C8@1224|Proteobacteria,2VR2X@28216|Betaproteobacteria,3T7TN@506|Alcaligenaceae 28216|Betaproteobacteria S DNA-binding protein - - - - - - - - - - - - DUF35_N,OB_aCoA_assoc k59_919768_1 640512.BC1003_3484 6.07e-130 395.0 COG0665@1|root,COG4121@1|root,COG0665@2|Bacteria,COG4121@2|Bacteria,1MZW5@1224|Proteobacteria,2VHGY@28216|Betaproteobacteria,1K1MC@119060|Burkholderiaceae 28216|Betaproteobacteria J Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 mnmC - 2.1.1.61 ko:K15461 - - R00601,R08702 RC00003,RC00053,RC00060,RC01483 ko00000,ko01000,ko03016 - - - DAO,Methyltransf_30 k59_1095444_1 880072.Desac_2552 5.62e-46 165.0 COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,42M28@68525|delta/epsilon subdivisions,2WJPF@28221|Deltaproteobacteria,2MQKP@213462|Syntrophobacterales 28221|Deltaproteobacteria S Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane murJ - - ko:K03980 - - - - ko00000,ko01011,ko02000 2.A.66.4 - - MVIN k59_1302750_1 640081.Dsui_1936 4.93e-75 238.0 COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,2VJ4R@28216|Betaproteobacteria,2KV5W@206389|Rhodocyclales 206389|Rhodocyclales F Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine mtaD - 3.5.4.28,3.5.4.31 ko:K12960 ko00270,ko01100,map00270,map01100 - R09660 RC00477 ko00000,ko00001,ko01000 - - - Amidohydro_1 k59_706595_1 999541.bgla_1g22610 2.25e-73 233.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2VH4C@28216|Betaproteobacteria,1JZQU@119060|Burkholderiaceae 28216|Betaproteobacteria I Belongs to the thiolase family bktB - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_493416_1 1000565.METUNv1_01293 5.2e-47 163.0 COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,2VHBW@28216|Betaproteobacteria,2KV3Y@206389|Rhodocyclales 206389|Rhodocyclales M zinc metalloprotease - - - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_M50 k59_493416_2 640081.Dsui_2686 3.64e-23 99.0 COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,2VHTX@28216|Betaproteobacteria,2KV13@206389|Rhodocyclales 206389|Rhodocyclales M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamA - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_1091247_2 264198.Reut_A0156 3.03e-09 54.3 COG3313@1|root,COG3313@2|Bacteria,1NGD5@1224|Proteobacteria,2VXYJ@28216|Betaproteobacteria 28216|Betaproteobacteria S Protein of unknown function (DUF1289) - - - ko:K06938 - - - - ko00000 - - - DUF1289 k59_1091247_3 1385517.N800_06100 6.15e-46 154.0 COG3917@1|root,COG3917@2|Bacteria,1MWB9@1224|Proteobacteria,1S4K8@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q 2-hydroxychromene-2-carboxylate isomerase - - 5.99.1.4 ko:K14584 ko00626,ko01100,ko01120,ko01220,map00626,map01100,map01120,map01220 M00534 R05137 RC03084 br01602,ko00000,ko00001,ko00002,ko01000 - - - DSBA k59_233473_3 1041147.AUFB01000020_gene5425 2.22e-13 68.6 COG0235@1|root,COG0235@2|Bacteria,1MW7B@1224|Proteobacteria,2TSX7@28211|Alphaproteobacteria,4BBQ1@82115|Rhizobiaceae 28211|Alphaproteobacteria G Class II Aldolase and Adducin N-terminal domain - - 4.1.1.104 ko:K22130 - - - - ko00000,ko01000 - - - Aldolase_II k59_447219_1 1165096.ARWF01000001_gene1483 7.59e-21 95.1 2A4J7@1|root,315VR@2|Bacteria,1NPWX@1224|Proteobacteria,2WGX3@28216|Betaproteobacteria,2KMVM@206350|Nitrosomonadales 206350|Nitrosomonadales S zinc-ribbon domain - - - - - - - - - - - - DUF3426,zinc_ribbon_5 k59_1129588_1 580332.Slit_0499 1.09e-86 276.0 COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,2VI7X@28216|Betaproteobacteria 28216|Betaproteobacteria NU general secretion pathway protein D gspD - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Secretin,Secretin_N k59_663979_1 1205680.CAKO01000002_gene3015 2.59e-70 220.0 COG1028@1|root,COG1028@2|Bacteria,1R3U8@1224|Proteobacteria,2U1SI@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ KR domain - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_962334_1 631454.N177_3895 1.58e-102 313.0 COG0651@1|root,COG0651@2|Bacteria,1QU5Z@1224|Proteobacteria,2U1B0@28211|Alphaproteobacteria,1JPY4@119043|Rhodobiaceae 28211|Alphaproteobacteria C Proton-conducting membrane transporter nuoL2 - 1.6.5.3 ko:K00341,ko:K05568 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000,ko02000 2.A.63.1,2.A.63.2,3.D.1 - - Proton_antipo_M,Proton_antipo_N k59_326580_2 59538.XP_005968316.1 2.35e-49 167.0 COG1235@1|root,2QWBK@2759|Eukaryota,39ZXT@33154|Opisthokonta 33154|Opisthokonta S Beta-lactamase superfamily domain - GO:0003674,GO:0003824,GO:0016787 - - - - - - - - - - Lactamase_B_2 k59_663982_1 1168289.AJKI01000011_gene381 3.18e-45 163.0 COG1680@1|root,COG1680@2|Bacteria,4NEVS@976|Bacteroidetes,2FQJ2@200643|Bacteroidia,3XJBY@558415|Marinilabiliaceae 976|Bacteroidetes V Beta-lactamase nylB - - - - - - - - - - - Beta-lactamase k59_1175616_1 983545.Glaag_2553 9.12e-37 132.0 COG1028@1|root,COG1028@2|Bacteria,1MUUV@1224|Proteobacteria,1RMJU@1236|Gammaproteobacteria,466CG@72275|Alteromonadaceae 1236|Gammaproteobacteria IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) ycdF - 1.5.1.33 ko:K03793 - - - - ko00000,ko01000 - - - adh_short_C2 k59_1175616_2 269482.Bcep1808_3068 3.58e-77 239.0 COG0037@1|root,COG0037@2|Bacteria,1MW5Q@1224|Proteobacteria,2VHWH@28216|Betaproteobacteria,1K0VT@119060|Burkholderiaceae 28216|Betaproteobacteria J Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system ttcA - - ko:K14058 - - - - ko00000,ko03016 - - - ATP_bind_3 k59_493581_1 314231.FP2506_13449 3.46e-56 189.0 COG4948@1|root,COG4948@2|Bacteria,1MW5B@1224|Proteobacteria,2UNXP@28211|Alphaproteobacteria,2PMG1@255475|Aurantimonadaceae 28211|Alphaproteobacteria M COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily gci - 5.5.1.27 ko:K18983 ko00053,map00053 - R10847 RC03287 ko00000,ko00001,ko01000 - - - MR_MLE_C,MR_MLE_N k59_1053360_1 156889.Mmc1_3650 1.28e-35 132.0 2B96M@1|root,322HU@2|Bacteria,1RIIU@1224|Proteobacteria,2UJE5@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_1218390_1 1035308.AQYY01000001_gene2491 2.51e-19 92.4 COG0612@1|root,COG0612@2|Bacteria 2|Bacteria L Peptidase, M16 - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C k59_831214_2 330214.NIDE2138 1.57e-46 164.0 COG4584@1|root,COG4584@2|Bacteria,3J15N@40117|Nitrospirae 40117|Nitrospirae L Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - HTH_7,rve k59_107764_1 1126627.BAWE01000005_gene6111 3.84e-53 191.0 COG1572@1|root,COG2931@1|root,COG3210@1|root,COG4070@1|root,COG1572@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4070@2|Bacteria,1MU7T@1224|Proteobacteria 1224|Proteobacteria Q COG2931, RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - Autotransporter,Cadherin-like,Calx-beta,DUF4347,He_PIG k59_1095732_1 1122137.AQXF01000005_gene1101 7.66e-76 238.0 COG2189@1|root,COG2189@2|Bacteria,1MX9M@1224|Proteobacteria,2TSW9@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Belongs to the N(4) N(6)-methyltransferase family ccrM - 2.1.1.72 ko:K13581 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko02048 - - - N6_N4_Mtase k59_706840_1 1120999.JONM01000005_gene3809 4.45e-52 177.0 COG3863@1|root,COG3863@2|Bacteria,1R0TY@1224|Proteobacteria,2VTGT@28216|Betaproteobacteria,2KT08@206351|Neisseriales 206351|Neisseriales S Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family - - - - - - - - - - - - Peptidase_C92 k59_706840_2 1072685.IX83_00810 4.32e-08 53.5 COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,2VI74@28216|Betaproteobacteria,3T375@506|Alcaligenaceae 28216|Betaproteobacteria L Exodeoxyribonuclease III exoA - 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos k59_1350442_3 1408164.MOLA814_01668 2.55e-12 63.5 2DMP1@1|root,32SS8@2|Bacteria,1MZTD@1224|Proteobacteria,2WG6B@28216|Betaproteobacteria 28216|Betaproteobacteria S Protein of unknown function (DUF3237) - - - - - - - - - - - - DUF3237 k59_831260_1 319225.Plut_0262 3.52e-21 94.4 COG0543@1|root,COG0543@2|Bacteria,1FDWW@1090|Chlorobi 1090|Chlorobi C PFAM oxidoreductase FAD NAD(P)-binding domain protein - - - ko:K02823 ko00240,ko01100,map00240,map01100 - - - ko00000,ko00001 - - - DHODB_Fe-S_bind,FAD_binding_6 k59_536335_2 393595.ABO_1108 8.8e-59 194.0 COG1305@1|root,COG1305@2|Bacteria,1MVMI@1224|Proteobacteria,1RNV8@1236|Gammaproteobacteria,1XIQP@135619|Oceanospirillales 135619|Oceanospirillales E Transglutaminase/protease-like homologues - - - - - - - - - - - - Bact_transglu_N,Transglut_core k59_536335_3 1033743.CAES01000059_gene4607 1.15e-42 150.0 COG1028@1|root,COG1028@2|Bacteria,1TR1J@1239|Firmicutes,4HAQ2@91061|Bacilli,26S5G@186822|Paenibacillaceae 91061|Bacilli IQ 3-ketoacyl-ACP reductase - - - - - - - - - - - - adh_short_C2 k59_1175759_1 1121374.KB891578_gene3227 2.79e-31 121.0 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria 1224|Proteobacteria P Acts as a magnesium transporter mgtE - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_1350472_1 216594.MMAR_1384 1.1e-24 104.0 COG2114@1|root,COG2114@2|Bacteria,2IDW7@201174|Actinobacteria,2382A@1762|Mycobacteriaceae 201174|Actinobacteria T Protein of unknown function (DUF2652) - - - - - - - - - - - - DUF2652 k59_278265_2 342113.DM82_1934 2.01e-110 338.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2VKNA@28216|Betaproteobacteria,1K135@119060|Burkholderiaceae 28216|Betaproteobacteria C acyl-CoA dehydrogenase aidB_1 - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M k59_493692_1 859657.RPSI07_mp1391 2.11e-22 95.1 COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,2VI13@28216|Betaproteobacteria,1K0VA@119060|Burkholderiaceae 28216|Betaproteobacteria NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR cheB - 3.1.1.61,3.5.1.44 ko:K03412 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,Response_reg k59_749500_1 279238.Saro_3118 7.37e-17 82.4 COG5323@1|root,COG5323@2|Bacteria,1MW8S@1224|Proteobacteria,2TREI@28211|Alphaproteobacteria,2K2BG@204457|Sphingomonadales 204457|Sphingomonadales S Terminase RNaseH-like domain - - - - - - - - - - - - Terminase_6,Terminase_6C k59_1303069_1 1028801.RG1141_CH01030 1.51e-158 451.0 COG0620@1|root,COG0620@2|Bacteria,1MUI9@1224|Proteobacteria,2TTWK@28211|Alphaproteobacteria,4BDWB@82115|Rhizobiaceae 28211|Alphaproteobacteria E Cobalamin-independent synthase, Catalytic domain metE - 2.1.1.14,4.4.1.23 ko:K00549,ko:K22363 ko00270,ko00450,ko00625,ko01100,ko01110,ko01230,map00270,map00450,map00625,map01100,map01110,map01230 M00017 R04405,R09365,R11897,R11899 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - Meth_synt_2 k59_1303069_2 1382303.JPOM01000001_gene2249 4.48e-29 113.0 COG3825@1|root,COG3825@2|Bacteria,1MUAJ@1224|Proteobacteria,2TS5P@28211|Alphaproteobacteria,2KG62@204458|Caulobacterales 204458|Caulobacterales S VWA domain containing CoxE-like protein - - - ko:K09989 - - - - ko00000 - - - VWA_CoxE k59_536359_1 639283.Snov_2965 4.07e-20 89.7 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,2TU67@28211|Alphaproteobacteria,3EYZJ@335928|Xanthobacteraceae 28211|Alphaproteobacteria E Aminotransferase class I and II - - - - - - - - - - - - Aminotran_1_2 k59_536359_2 1218076.BAYB01000007_gene1403 1.7e-41 145.0 COG0598@1|root,COG0598@2|Bacteria,1MX09@1224|Proteobacteria,2VHCH@28216|Betaproteobacteria,1JZUF@119060|Burkholderiaceae 28216|Betaproteobacteria P Mediates influx of magnesium ions corA - - ko:K03284 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3 - - CorA k59_326752_1 1502851.FG93_02624 6.4e-05 44.7 COG3415@1|root,COG3415@2|Bacteria,1ND8F@1224|Proteobacteria,2UEU9@28211|Alphaproteobacteria,3K4U5@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - HTH_28,HTH_Tnp_IS630 k59_326752_2 991905.SL003B_0699 3.97e-80 240.0 COG3335@1|root,COG3335@2|Bacteria,1P76X@1224|Proteobacteria,2U16U@28211|Alphaproteobacteria,4BRN6@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria L DDE superfamily endonuclease - - - - - - - - - - - - DDE_3 k59_576623_1 566466.NOR53_2103 2.78e-24 107.0 COG2982@1|root,COG2982@2|Bacteria,1QQSY@1224|Proteobacteria,1SKSB@1236|Gammaproteobacteria,1J7P9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M AsmA family - - - - - - - - - - - - AsmA,AsmA_2 k59_749543_1 1380391.JIAS01000002_gene3168 6e-67 225.0 COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,2TQV8@28211|Alphaproteobacteria,2JQ45@204441|Rhodospirillales 204441|Rhodospirillales J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily pheT - 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5,FDX-ACB,tRNA_bind k59_1218538_1 1323663.AROI01000009_gene3694 8.62e-33 131.0 COG2072@1|root,COG2072@2|Bacteria,1MU71@1224|Proteobacteria,1RP8X@1236|Gammaproteobacteria 1236|Gammaproteobacteria P flavoprotein involved in K transport ethA GO:0003674,GO:0003824,GO:0004497,GO:0008150,GO:0008152,GO:0016491,GO:0016705,GO:0016709,GO:0055114 - - - - - - - - - - FMO-like,NAD_binding_8,Pyr_redox_3 k59_1261273_1 1122614.JHZF01000014_gene2590 1.56e-16 78.2 COG3868@1|root,COG3868@2|Bacteria 2|Bacteria S Glycoside-hydrolase family GH114 - - - ko:K21006 ko02025,map02025 - - - ko00000,ko00001 - - - Glyco_hydro_114,Stealth_CR1,Stealth_CR2,Stealth_CR4 k59_27045_1 1207063.P24_14619 8.85e-106 314.0 COG3221@1|root,COG3221@2|Bacteria,1MWFF@1224|Proteobacteria,2TUB4@28211|Alphaproteobacteria,2JQT4@204441|Rhodospirillales 204441|Rhodospirillales P ABC-type phosphate phosphonate transport system periplasmic component - - - ko:K02044 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - Phosphonate-bd k59_1095944_1 857087.Metme_0891 3.26e-116 347.0 COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,1RMYV@1236|Gammaproteobacteria,1XE7G@135618|Methylococcales 135618|Methylococcales O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis hslU - - ko:K03667 - - - - ko00000,ko03110 - - - AAA_2,ClpB_D2-small k59_107965_1 322710.Avin_44060 6.91e-32 124.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296,ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_107965_2 522306.CAP2UW1_0167 4.85e-68 220.0 COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,2VINC@28216|Betaproteobacteria,1KQRX@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family acrA - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD_D23 k59_107972_1 76114.p2A120 5.57e-92 288.0 COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria 1224|Proteobacteria H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis - - 4.1.1.98 ko:K03182 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04985,R04986 RC00391 ko00000,ko00001,ko00002,ko01000 - - - UbiD k59_150346_1 381666.H16_B1840 7.64e-127 374.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VMYW@28216|Betaproteobacteria,1K1RG@119060|Burkholderiaceae 28216|Betaproteobacteria C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_370124_1 521393.JH806633_gene1886 3.37e-07 52.4 COG0667@1|root,COG0667@2|Bacteria,2GMT5@201174|Actinobacteria,4D4BK@85005|Actinomycetales 201174|Actinobacteria C aldo keto reductase - - - - - - - - - - - - Aldo_ket_red k59_370124_2 1504672.669786087 1.6e-62 213.0 COG2307@1|root,COG2308@1|root,COG2307@2|Bacteria,COG2308@2|Bacteria,1MX5P@1224|Proteobacteria,2VJEU@28216|Betaproteobacteria,4ABDP@80864|Comamonadaceae 28216|Betaproteobacteria S A predicted alpha-helical domain with a conserved ER motif. - - - - - - - - - - - - Alpha-E,CP_ATPgrasp_2 k59_749659_1 1313172.YM304_09640 4.78e-71 234.0 COG1138@1|root,COG1138@2|Bacteria,2HZM9@201174|Actinobacteria,4CMX6@84992|Acidimicrobiia 84992|Acidimicrobiia O Cytochrome c-type biogenesis protein CcmF C-terminal ccmF - - ko:K02198 - - - - ko00000,ko02000 9.B.14.1 - - CcmF_C,Cytochrom_C_asm k59_27132_1 470704.XP_007760153.1 2.94e-47 162.0 COG1028@1|root,KOG0725@2759|Eukaryota,38HKW@33154|Opisthokonta,3NYCF@4751|Fungi,3RMQ7@4890|Ascomycota,20U5W@147545|Eurotiomycetes,3MUAP@451870|Chaetothyriomycetidae 4751|Fungi Q KR domain - - - - - - - - - - - - adh_short_C2 k59_536547_1 1288494.EBAPG3_26350 3.93e-85 264.0 COG0265@1|root,COG3016@1|root,COG0265@2|Bacteria,COG3016@2|Bacteria,1MX1I@1224|Proteobacteria,2VPEA@28216|Betaproteobacteria,3729T@32003|Nitrosomonadales 28216|Betaproteobacteria O pdz dhr glgf - - - - - - - - - - - - Cofac_haem_bdg,PDZ_2 k59_278484_1 485913.Krac_2433 2.27e-50 164.0 COG2080@1|root,COG2080@2|Bacteria,2G6NT@200795|Chloroflexi 200795|Chloroflexi C 2Fe-2S -binding domain protein - - 1.2.5.3 ko:K03518 - - R11168 RC02800 ko00000,ko01000 - - - Fer2,Fer2_2 k59_278484_2 28258.KP05_09080 5.9e-12 64.3 COG1309@1|root,COG1309@2|Bacteria,1RGJ3@1224|Proteobacteria,1S2ZZ@1236|Gammaproteobacteria,1XKI7@135619|Oceanospirillales 135619|Oceanospirillales K transcriptional regulator - - - - - - - - - - - - TetR_C_4,TetR_N k59_1218726_2 13690.CP98_01340 1.19e-24 104.0 COG0729@1|root,COG0729@2|Bacteria,1PFDU@1224|Proteobacteria,2V2VW@28211|Alphaproteobacteria,2KB7Y@204457|Sphingomonadales 204457|Sphingomonadales M PFAM Surface antigen - - - - - - - - - - - - Bac_surface_Ag k59_72196_1 640081.Dsui_3083 6.59e-77 244.0 COG0683@1|root,COG0683@2|Bacteria,1MWR8@1224|Proteobacteria,2VHH6@28216|Betaproteobacteria,2KVK6@206389|Rhodocyclales 206389|Rhodocyclales E amino acid - - - - - - - - - - - - Peripla_BP_6 k59_108063_1 568816.Acin_0259 3.21e-51 178.0 COG0536@1|root,COG0536@2|Bacteria,1TPX7@1239|Firmicutes,4H279@909932|Negativicutes 909932|Negativicutes S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control obg - - ko:K03979 - - - - ko00000,ko01000,ko03009 - - - DUF1967,GTP1_OBG,MMR_HSR1 k59_920330_1 640081.Dsui_1564 3.53e-17 86.3 COG4191@1|root,COG5000@1|root,COG5001@1|root,COG4191@2|Bacteria,COG5000@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KV2U@206389|Rhodocyclales 206389|Rhodocyclales T PAS fold - - - - - - - - - - - - EAL,GGDEF,PAS_4,PAS_7,PAS_8,PAS_9 k59_451402_1 1117958.PE143B_0114515 1.17e-19 94.4 COG3225@1|root,COG3225@2|Bacteria,1MY63@1224|Proteobacteria,1RP5E@1236|Gammaproteobacteria 1236|Gammaproteobacteria N transport system involved in gliding motility, auxiliary component - - - - - - - - - - - - ABC_transp_aux k59_576858_1 864069.MicloDRAFT_00068520 3.75e-14 72.4 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,2TSU1@28211|Alphaproteobacteria,1JZ1Y@119045|Methylobacteriaceae 28211|Alphaproteobacteria C Citrate synthase, C-terminal domain citA - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_576858_2 266117.Rxyl_2556 3.02e-24 102.0 COG0372@1|root,COG0372@2|Bacteria,2GM3G@201174|Actinobacteria,4CT9Z@84995|Rubrobacteria 84995|Rubrobacteria C Helix-turn-helix domain - - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt,HTH_17 k59_1005241_1 272560.BPSL0443 6.89e-87 261.0 COG0588@1|root,COG0588@2|Bacteria,1MUVE@1224|Proteobacteria,2VHEK@28216|Betaproteobacteria,1K21Q@119060|Burkholderiaceae 28216|Betaproteobacteria F Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily gpmA - 5.4.2.11 ko:K01834 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - His_Phos_1 k59_451434_1 292415.Tbd_0433 7.39e-13 67.8 COG2379@1|root,COG2379@2|Bacteria,1MVIK@1224|Proteobacteria,2VHXK@28216|Betaproteobacteria 28216|Betaproteobacteria G hydroxypyruvate reductase ttuD2 - 2.7.1.165 ko:K11529 ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200 M00346 R08572 RC00002,RC00428 ko00000,ko00001,ko00002,ko01000 - - - DUF4147,MOFRL k59_451434_3 1122604.JONR01000006_gene2665 3.22e-22 90.1 COG0203@1|root,COG0203@2|Bacteria,1RCWN@1224|Proteobacteria,1S3QK@1236|Gammaproteobacteria,1X6D2@135614|Xanthomonadales 135614|Xanthomonadales J Ribosomal protein L17 rplQ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02879 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L17 k59_874557_1 1122604.JONR01000005_gene916 2.17e-78 246.0 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,1RNN0@1236|Gammaproteobacteria,1X3M5@135614|Xanthomonadales 135614|Xanthomonadales E aminotransferase - - 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_1096157_1 1353537.TP2_13715 3.08e-10 66.2 COG1511@1|root,COG2931@1|root,COG1511@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q COG2931 RTX toxins and related Ca2 -binding proteins - - 3.4.24.40 ko:K01406,ko:K07004 ko01503,map01503 - - - ko00000,ko00001,ko01000,ko01002 - - - Cadherin,Calx-beta,HemolysinCabind,LTD,Peptidase_M10,Peptidase_M10_C,W_rich_C k59_408814_1 926569.ANT_10860 8.6e-88 288.0 COG0086@1|root,COG0086@2|Bacteria,2G632@200795|Chloroflexi 200795|Chloroflexi K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_370307_1 1463864.JOGO01000010_gene3237 7.4e-08 54.7 COG1816@1|root,COG1816@2|Bacteria,2GJ6I@201174|Actinobacteria 201174|Actinobacteria F Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism add2 GO:0000034,GO:0003674,GO:0003824,GO:0006139,GO:0006144,GO:0006145,GO:0006146,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0034641,GO:0034654,GO:0042440,GO:0043094,GO:0043096,GO:0043101,GO:0043103,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0046083,GO:0046100,GO:0046101,GO:0046112,GO:0046113,GO:0046148,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.5.4.4,3.5.4.40 ko:K01488,ko:K18286 ko00130,ko00230,ko01100,ko01110,ko05340,map00130,map00230,map01100,map01110,map05340 - R01560,R02556,R10695 RC00477 ko00000,ko00001,ko01000 - - - A_deaminase k59_370307_2 1444309.JAQG01000031_gene2895 5.69e-37 129.0 COG1051@1|root,COG1051@2|Bacteria,1V6D5@1239|Firmicutes,4HJTU@91061|Bacilli,26XD5@186822|Paenibacillaceae 91061|Bacilli F NUDIX domain - - - - - - - - - - - - NUDIX k59_108172_1 331869.BAL199_29962 9.94e-68 218.0 COG0667@1|root,COG0667@2|Bacteria,1R5BH@1224|Proteobacteria,2TS0A@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red k59_1053903_1 269796.Rru_A2721 5.38e-100 311.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,2TU21@28211|Alphaproteobacteria,2JRK3@204441|Rhodospirillales 204441|Rhodospirillales C Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg - - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N,Transketolase_C k59_1350832_1 592015.HMPREF1705_00101 1.83e-30 119.0 COG2897@1|root,COG2897@2|Bacteria,3TA04@508458|Synergistetes 508458|Synergistetes P PFAM Rhodanese domain protein - - 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese k59_1350832_2 1121949.AQXT01000002_gene1633 1.62e-37 132.0 COG0500@1|root,COG2226@2|Bacteria,1RANW@1224|Proteobacteria,2U66N@28211|Alphaproteobacteria,43XIB@69657|Hyphomonadaceae 28211|Alphaproteobacteria Q UbiE COQ5 family methyltransferase - - - - - - - - - - - - Methyltransf_11,Methyltransf_23 k59_195625_1 760568.Desku_2268 2.82e-80 256.0 COG0147@1|root,COG0147@2|Bacteria,1TQAP@1239|Firmicutes,24946@186801|Clostridia,26020@186807|Peptococcaceae 186801|Clostridia EH Anthranilate synthase component I pabB - 2.6.1.85,4.1.3.27 ko:K01657,ko:K01665,ko:K13950 ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986,R01716 RC00010,RC01418,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind,GATase k59_278632_1 713586.KB900536_gene258 1.15e-89 277.0 COG3202@1|root,COG3202@2|Bacteria,1MVP5@1224|Proteobacteria,1RNY6@1236|Gammaproteobacteria 1236|Gammaproteobacteria C ATP ADP translocase - - - ko:K03301 - - - - ko00000 2.A.12 - - MFS_1,TLC k59_496320_2 472759.Nhal_1348 9.81e-65 212.0 COG1858@1|root,COG1858@2|Bacteria,1RC4D@1224|Proteobacteria,1SJKT@1236|Gammaproteobacteria 1236|Gammaproteobacteria C cytochrome C peroxidase - - - - - - - - - - - - - k59_579233_1 1123504.JQKD01000003_gene595 2.5e-08 61.6 COG4966@1|root,COG4966@2|Bacteria,1RH2G@1224|Proteobacteria,2VQ2C@28216|Betaproteobacteria,4AFZ5@80864|Comamonadaceae 28216|Betaproteobacteria NU Type IV Pilus-assembly protein W - - - ko:K02672 - - - - ko00000,ko02035,ko02044 - - - N_methyl,PilW k59_579233_2 580332.Slit_2084 5.15e-20 87.4 COG4967@1|root,COG4967@2|Bacteria,1N7AC@1224|Proteobacteria,2VW8B@28216|Betaproteobacteria,44W3Z@713636|Nitrosomonadales 28216|Betaproteobacteria NU type IV pilus modification protein PilV - - - ko:K02671 - - - - ko00000,ko02035,ko02044 - - - N_methyl k59_29603_1 575540.Isop_2172 2.39e-83 271.0 COG3383@1|root,COG3383@2|Bacteria,2J4XN@203682|Planctomycetes 203682|Planctomycetes C 2Fe-2S iron-sulfur cluster binding domain - - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Fer2_4,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_538951_1 1095769.CAHF01000022_gene349 3.11e-39 141.0 COG0657@1|root,COG0657@2|Bacteria,1NEXK@1224|Proteobacteria,2VPP7@28216|Betaproteobacteria,4724Q@75682|Oxalobacteraceae 28216|Betaproteobacteria I alpha/beta hydrolase fold - - - ko:K01066 - - - - ko00000,ko01000 - - - Abhydrolase_3 k59_538951_2 1380355.JNIJ01000013_gene369 1.83e-53 170.0 2E5W4@1|root,330K6@2|Bacteria,1N893@1224|Proteobacteria,2UGUZ@28211|Alphaproteobacteria,3K16Z@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S NIPSNAP - - - - - - - - - - - - NIPSNAP k59_538951_3 305700.B447_13779 4.25e-37 128.0 COG1832@1|root,COG1832@2|Bacteria,1N03D@1224|Proteobacteria,2VU9G@28216|Betaproteobacteria,2KWFV@206389|Rhodocyclales 206389|Rhodocyclales S CoA-binding protein - - - ko:K06929 - - - - ko00000 - - - CoA_binding_2 k59_1056640_1 292.DM42_3196 1.41e-96 292.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2VIF8@28216|Betaproteobacteria,1K03I@119060|Burkholderiaceae 28216|Betaproteobacteria I Belongs to the thiolase family - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_1007608_1 375286.mma_0881 8.18e-46 153.0 COG2862@1|root,COG2862@2|Bacteria,1RANN@1224|Proteobacteria,2VK3P@28216|Betaproteobacteria,472DS@75682|Oxalobacteraceae 28216|Betaproteobacteria S Uncharacterized protein family, UPF0114 - - - - - - - - - - - - UPF0114 k59_1007608_2 1175306.GWL_09940 6.22e-101 307.0 COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,1MUV9@1224|Proteobacteria,2VIP7@28216|Betaproteobacteria,472YG@75682|Oxalobacteraceae 28216|Betaproteobacteria C Catalyzes the reversible hydration of fumarate to (S)- malate fumA - 4.2.1.2 ko:K01676 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - Fumerase,Fumerase_C k59_1056667_1 1411123.JQNH01000001_gene3691 1.29e-60 207.0 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TWGU@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding - - - - - - - - - - - - Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2 k59_1056667_2 1121106.JQKB01000022_gene3704 7.42e-26 105.0 COG2816@1|root,COG2816@2|Bacteria,1MV1F@1224|Proteobacteria,2TTRT@28211|Alphaproteobacteria,2JQZX@204441|Rhodospirillales 204441|Rhodospirillales L COG1180 Pyruvate-formate lyase-activating enzyme - - - - - - - - - - - - - k59_876727_1 497964.CfE428DRAFT_1238 2.69e-75 241.0 COG1032@1|root,COG1032@2|Bacteria 2|Bacteria C radical SAM domain protein - - - - - - - - - - - - B12-binding,DUF4070,Radical_SAM k59_1178510_2 983917.RGE_41790 0.000803 44.7 COG1612@1|root,COG1612@2|Bacteria,1MVJ4@1224|Proteobacteria,2VJ3C@28216|Betaproteobacteria,1KIW2@119065|unclassified Burkholderiales 28216|Betaproteobacteria O cytochrome oxidase assembly ctaA - - ko:K02259 ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714 M00154 R07412 RC00769 ko00000,ko00001,ko00002,ko03029 3.D.4.4 - - COX15-CtaA k59_411565_2 1205680.CAKO01000014_gene92 2.11e-77 254.0 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria,2JW0J@204441|Rhodospirillales 204441|Rhodospirillales C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - - - - - - - - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_1007654_1 323848.Nmul_A1548 2.97e-58 192.0 COG2170@1|root,COG2170@2|Bacteria,1MX4N@1224|Proteobacteria,2VK27@28216|Betaproteobacteria,372V9@32003|Nitrosomonadales 28216|Betaproteobacteria H ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity ybdK - - ko:K06048 - - - - ko00000,ko01000 - - - GCS2 k59_1007654_2 375286.mma_2606 1.56e-26 112.0 COG0475@1|root,COG0475@2|Bacteria,1R9PF@1224|Proteobacteria,2VKV2@28216|Betaproteobacteria,4748Y@75682|Oxalobacteraceae 28216|Betaproteobacteria P Sodium/hydrogen exchanger family - - - - - - - - - - - - Na_H_Exchanger k59_372686_1 338963.Pcar_0304 4.57e-20 92.4 COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,42PYA@68525|delta/epsilon subdivisions,2WKM5@28221|Deltaproteobacteria,43SWI@69541|Desulfuromonadales 28221|Deltaproteobacteria E TIGRFAM cysteine desulfurase family protein - - 2.8.1.7,4.4.1.16 ko:K11717 ko00450,ko01100,map00450,map01100 - R03599,R11528 RC00961,RC01789,RC02313 ko00000,ko00001,ko01000 - - - Aminotran_5 k59_1263913_1 1283300.ATXB01000001_gene88 4.85e-15 79.7 COG3174@1|root,COG3174@2|Bacteria,1NDBI@1224|Proteobacteria,1RRGY@1236|Gammaproteobacteria,1XENB@135618|Methylococcales 135618|Methylococcales S Domain of unknown function (DUF4010) - - - - - - - - - - - - DUF4010 k59_372703_1 1219035.NT2_01_05500 4.69e-75 242.0 COG0318@1|root,COG0318@2|Bacteria,1MWSD@1224|Proteobacteria,2TU6Y@28211|Alphaproteobacteria,2JZVW@204457|Sphingomonadales 204457|Sphingomonadales IQ AMP-binding enzyme - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_798900_1 1121116.KB894765_gene878 3.55e-73 233.0 COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,2VIWB@28216|Betaproteobacteria,4AAKI@80864|Comamonadaceae 28216|Betaproteobacteria C Belongs to the heme-copper respiratory oxidase family ccoN - 1.9.3.1 ko:K00404 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - COX1 k59_798900_2 983917.RGE_31920 3.41e-48 159.0 COG2993@1|root,COG2993@2|Bacteria,1MXEY@1224|Proteobacteria,2VIJ2@28216|Betaproteobacteria,1KJRV@119065|unclassified Burkholderiales 28216|Betaproteobacteria C cytochrome C oxidase ccoO - - ko:K00405 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - FixO k59_752226_1 338963.Pcar_2866 1.54e-51 176.0 COG3303@1|root,COG3303@2|Bacteria,1MVJT@1224|Proteobacteria,42MPU@68525|delta/epsilon subdivisions,2WIJ1@28221|Deltaproteobacteria,43UNQ@69541|Desulfuromonadales 28221|Deltaproteobacteria C Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process nrfA - 1.7.2.2 ko:K03385 ko00910,ko01120,ko05132,map00910,map01120,map05132 M00530 R05712 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Cytochrom_C552 k59_798908_2 1469245.JFBG01000097_gene1349 7.62e-50 167.0 COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,1RNDV@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the binding-protein-dependent transport system permease family - - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_1263925_2 406818.XBJ1_1190 1.01e-80 264.0 COG0305@1|root,COG0305@2|Bacteria,1R4AH@1224|Proteobacteria,1RN7M@1236|Gammaproteobacteria 1236|Gammaproteobacteria L DNA helicase - - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_152975_1 977880.RALTA_B0347 2.03e-72 227.0 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2VJM2@28216|Betaproteobacteria,1K3CW@119060|Burkholderiaceae 28216|Betaproteobacteria E Catalyzes the formation of 2-oxobutanoate from L-threonine or the formation of pyruvate from serine tdcB - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_152975_2 1122604.JONR01000004_gene881 3.71e-31 117.0 COG0596@1|root,COG0596@2|Bacteria,1MUSF@1224|Proteobacteria,1RP4C@1236|Gammaproteobacteria,1X3HD@135614|Xanthomonadales 135614|Xanthomonadales S Alpha beta hydrolase dhaA - - ko:K22318 - - - - ko00000 - - - Abhydrolase_1 k59_922893_1 1123326.JFBL01000013_gene338 1.22e-15 72.4 COG3651@1|root,COG3651@2|Bacteria,1RH68@1224|Proteobacteria,42TUY@68525|delta/epsilon subdivisions 1224|Proteobacteria S Uncharacterized protein conserved in bacteria (DUF2237) - - - ko:K09966 - - - - ko00000 - - - DUF2237 k59_922893_2 667014.Thein_0116 1.64e-12 70.1 COG0664@1|root,COG0664@2|Bacteria,2GHZ5@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria K helix_turn_helix, cAMP Regulatory protein - - - ko:K21563 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding k59_1007707_1 936136.ARRT01000007_gene1027 1.62e-34 130.0 COG1858@1|root,COG1858@2|Bacteria,1QVCJ@1224|Proteobacteria,2V1D7@28211|Alphaproteobacteria,4BBRB@82115|Rhizobiaceae 28211|Alphaproteobacteria C cytochrome C peroxidase - - - - - - - - - - - - - k59_1007707_2 492774.JQMB01000003_gene2592 4.78e-26 100.0 2F7MQ@1|root,34027@2|Bacteria,1N3M0@1224|Proteobacteria,2UTUH@28211|Alphaproteobacteria,4BEVB@82115|Rhizobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_833736_1 247634.GPB2148_1491 5.22e-57 190.0 COG1028@1|root,COG1028@2|Bacteria,1REA0@1224|Proteobacteria,1SMHH@1236|Gammaproteobacteria 1236|Gammaproteobacteria IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - - - - - - - - - - adh_short k59_965313_1 1173263.Syn7502_03215 1.07e-50 172.0 COG0346@1|root,COG0346@2|Bacteria,1G29P@1117|Cyanobacteria,1H0UQ@1129|Synechococcus 1117|Cyanobacteria E PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - - - - - - - - - - Glyoxalase k59_965313_2 221288.JH992901_gene4091 8.33e-06 46.6 COG2303@1|root,COG2303@2|Bacteria,1G2DQ@1117|Cyanobacteria,1JHUA@1189|Stigonemataceae 1117|Cyanobacteria E GMC oxidoreductase - - - - - - - - - - - - GMC_oxred_C,GMC_oxred_N k59_29777_1 1294142.CINTURNW_2837 3.5e-18 84.3 COG0801@1|root,COG1539@1|root,COG0801@2|Bacteria,COG1539@2|Bacteria,1V6PR@1239|Firmicutes,249YP@186801|Clostridia,36ECT@31979|Clostridiaceae 186801|Clostridia H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin folK - 2.7.6.3,4.1.2.25 ko:K00950,ko:K13940 ko00790,ko01100,map00790,map01100 M00126,M00841 R03503,R03504 RC00002,RC00017,RC00721,RC00943 ko00000,ko00001,ko00002,ko01000 - - - FolB,HPPK k59_1056833_1 1348657.M622_06015 2.17e-16 78.2 29CX4@1|root,2ZZV8@2|Bacteria,1RFY7@1224|Proteobacteria,2VR98@28216|Betaproteobacteria,2KWGK@206389|Rhodocyclales 206389|Rhodocyclales S Domain of unknown function (DUF4390) - - - - - - - - - - - - DUF4390 k59_1056833_2 640081.Dsui_0810 9.11e-07 51.6 COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,2VIDI@28216|Betaproteobacteria,2KV2P@206389|Rhodocyclales 206389|Rhodocyclales T Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_1306211_1 1205680.CAKO01000029_gene5115 5.3e-112 332.0 COG2141@1|root,COG2141@2|Bacteria,1R7GC@1224|Proteobacteria,2U0DW@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_1264009_1 999541.bgla_1g33430 7.44e-66 210.0 COG0468@1|root,COG0468@2|Bacteria,1MU3C@1224|Proteobacteria,2VHNA@28216|Betaproteobacteria,1K09V@119060|Burkholderiaceae 28216|Betaproteobacteria L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA - - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA k59_1264011_1 107636.JQNK01000004_gene826 1.42e-29 117.0 COG1994@1|root,COG1994@2|Bacteria,1MW9I@1224|Proteobacteria,2U0H8@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Peptidase, M50 family - - - ko:K16922 - - - - ko00000,ko01002 - - - Biotin_lipoyl_2,PqqD k59_1264011_2 1298867.AUES01000051_gene4507 1.81e-90 286.0 COG0845@1|root,COG0845@2|Bacteria,1N97Q@1224|Proteobacteria,2U22Z@28211|Alphaproteobacteria,3K3DU@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - - - - - - - - - - Biotin_lipoyl_2,GAF,HlyD_3,HlyD_D23 k59_876863_1 1217718.ALOU01000110_gene2928 3.11e-09 63.5 COG2801@1|root,COG2801@2|Bacteria,1N207@1224|Proteobacteria,2VRA9@28216|Betaproteobacteria,1K6DX@119060|Burkholderiaceae 28216|Betaproteobacteria L leucine-zipper of insertion element IS481 - - - - - - - - - - - - HTH_32,LZ_Tnp_IS481,rve,rve_3 k59_922986_1 998674.ATTE01000001_gene293 2.72e-76 251.0 COG0749@1|root,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,45ZUW@72273|Thiotrichales 72273|Thiotrichales L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_1099144_1 999541.bgla_1g22660 5.31e-77 237.0 COG1028@1|root,COG1028@2|Bacteria,1MUEV@1224|Proteobacteria,2VH8R@28216|Betaproteobacteria,1K2WG@119060|Burkholderiaceae 28216|Betaproteobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family phbB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 1.1.1.36 ko:K00023 ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200 M00373 R01779,R01977 RC00103,RC00117 ko00000,ko00001,ko00002,ko01000 - - - adh_short,adh_short_C2 k59_1353347_1 580332.Slit_2504 1.51e-30 124.0 COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,2VHE1@28216|Betaproteobacteria,44WEE@713636|Nitrosomonadales 28216|Betaproteobacteria T SMART CBS domain containing protein - - - ko:K07182 - - - - ko00000 - - - CBS,DUF294,DUF294_C,cNMP_binding k59_965406_1 1396141.BATP01000019_gene1716 1.4e-56 186.0 COG1131@1|root,COG1131@2|Bacteria,46UCI@74201|Verrucomicrobia,2IU5T@203494|Verrucomicrobiae 203494|Verrucomicrobiae V ATPases associated with a variety of cellular activities - - - - - - - - - - - - ABC_tran k59_965406_2 1054213.HMPREF9946_03526 0.000436 42.4 COG1277@1|root,COG1277@2|Bacteria,1NZZ9@1224|Proteobacteria,2TUXR@28211|Alphaproteobacteria,2JS1D@204441|Rhodospirillales 204441|Rhodospirillales S ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2,ABC2_membrane_3 k59_630297_1 2340.JV46_18960 5.25e-13 73.6 COG3297@1|root,COG3297@2|Bacteria,1NVVW@1224|Proteobacteria,1S01F@1236|Gammaproteobacteria,1JB3D@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins gspL GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705 - ko:K02461 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - GspL_C,T2SSL k59_198158_2 1244869.H261_09737 2.38e-28 111.0 COG1947@1|root,COG1947@2|Bacteria,1MVU3@1224|Proteobacteria,2TUFV@28211|Alphaproteobacteria,2JRVD@204441|Rhodospirillales 204441|Rhodospirillales I Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol ispE - 2.7.1.148 ko:K00919 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05634 RC00002,RC01439 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N k59_539215_1 1158292.JPOE01000002_gene1439 2.75e-85 278.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,2VI4A@28216|Betaproteobacteria,1KJ1Z@119065|unclassified Burkholderiales 28216|Betaproteobacteria F Carbamoyl-phosphate synthetase ammonia chain carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_833846_1 306281.AJLK01000102_gene3416 2.33e-12 67.4 COG0154@1|root,COG0154@2|Bacteria 2|Bacteria J amidase activity - - 3.5.1.4,6.3.5.6,6.3.5.7 ko:K01426,ko:K02433 ko00330,ko00360,ko00380,ko00627,ko00643,ko00970,ko01100,ko01120,map00330,map00360,map00380,map00627,map00643,map00970,map01100,map01120 - R02540,R03096,R03180,R03905,R03909,R04212,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_833846_2 1038859.AXAU01000005_gene5142 4.97e-29 110.0 COG3350@1|root,COG3350@2|Bacteria,1N0GC@1224|Proteobacteria,2UBRM@28211|Alphaproteobacteria,3JXT6@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S YHS domain protein - - - - - - - - - - - - YHS k59_630324_1 1042377.AFPJ01000042_gene1089 1.78e-24 102.0 COG1028@1|root,COG1028@2|Bacteria,1R413@1224|Proteobacteria,1RSKB@1236|Gammaproteobacteria,4667I@72275|Alteromonadaceae 1236|Gammaproteobacteria IQ Short-chain dehydrogenase reductase sDR - - - - - - - - - - - - adh_short_C2 k59_153176_1 1286093.C266_10876 3.22e-89 293.0 COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,2VKIR@28216|Betaproteobacteria,1K20Q@119060|Burkholderiaceae 28216|Betaproteobacteria E NAD-glutamate dehydrogenase gdhB - 1.4.1.2 ko:K15371 ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100 - R00243 RC00006,RC02799 ko00000,ko00001,ko01000 - - - Bac_GDH k59_1221522_1 1150626.PHAMO_10121 1.66e-22 99.0 COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,2TT03@28211|Alphaproteobacteria,2JPHV@204441|Rhodospirillales 204441|Rhodospirillales L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA - - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k59_411883_1 1333998.M2A_1070 1.42e-49 170.0 COG3386@1|root,COG3386@2|Bacteria,1NIN4@1224|Proteobacteria,2U3KK@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Major royal jelly protein - - - - - - - - - - - - MRJP k59_1132406_1 859657.RPSI07_1914 1.85e-07 53.9 2E56W@1|root,32ZZK@2|Bacteria,1NET3@1224|Proteobacteria,2VX54@28216|Betaproteobacteria,1K73D@119060|Burkholderiaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_281266_1 500635.MITSMUL_04697 1.36e-18 82.8 COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,4H22T@909932|Negativicutes 909932|Negativicutes V Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides macB - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_281266_2 1163617.SCD_n00408 1.96e-22 97.1 COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,2VJR5@28216|Betaproteobacteria 28216|Betaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K02005 - - - - ko00000 - - - HlyD_D23 k59_1306415_2 399795.CtesDRAFT_PD3088 3.99e-20 88.6 COG0119@1|root,COG0119@2|Bacteria,1MUMX@1224|Proteobacteria,2VHK4@28216|Betaproteobacteria,4AJ7S@80864|Comamonadaceae 28216|Betaproteobacteria E Pyruvate carboxyltransferase - - 4.1.3.4 ko:K01640 ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146 M00036,M00088 R01360,R08090 RC00502,RC00503,RC01118,RC01946 ko00000,ko00001,ko00002,ko01000 - - - HMGL-like k59_709896_1 272624.lpg1873 8.4e-12 67.8 COG2951@1|root,COG2951@2|Bacteria,1MUZ3@1224|Proteobacteria,1RMQ6@1236|Gammaproteobacteria,1JCNE@118969|Legionellales 118969|Legionellales M Transglycosylase SLT domain mltB_2 - - ko:K08305 - - - - ko00000,ko01000,ko01011 - GH103 - SLT_2 k59_709896_2 94624.Bpet0442 2.86e-22 95.1 COG0797@1|root,COG3087@1|root,COG0797@2|Bacteria,COG3087@2|Bacteria,1MZ8S@1224|Proteobacteria,2VJAN@28216|Betaproteobacteria 28216|Betaproteobacteria M Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides rlpA - - ko:K03642 - - - - ko00000 - - - DPBB_1,SPOR k59_329469_2 1163617.SCD_n01783 1.17e-31 116.0 COG3063@1|root,COG3063@2|Bacteria,1N7DT@1224|Proteobacteria,2VW37@28216|Betaproteobacteria 28216|Betaproteobacteria NU Type IV pilus biogenesis stability protein PilW - - - - - - - - - - - - - k59_583785_1 1121035.AUCH01000003_gene1377 3.35e-69 234.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VJBX@28216|Betaproteobacteria,2KU9U@206389|Rhodocyclales 206389|Rhodocyclales NT Methyl-accepting chemotaxis protein pilJ - - ko:K02660 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001,ko02035,ko02044 - - - MCPsignal,PilJ k59_1012041_1 1220601.L7TJ71_9CAUD 3.19e-15 82.0 4QAKM@10239|Viruses,4QUU7@35237|dsDNA viruses no RNA stage,4QPEF@28883|Caudovirales 28883|Caudovirales S DNA polymerase family A - GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 - - - - - - - - - - - k59_756569_1 1122222.AXWR01000026_gene1629 4.37e-66 213.0 COG1638@1|root,COG1638@2|Bacteria,1WJNF@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus G TRAP-type C4-dicarboxylate transport system periplasmic component - - - - - - - - - - - - DctP k59_377147_1 1122929.KB908230_gene3708 2.87e-70 219.0 COG0670@1|root,COG0670@2|Bacteria,1MU69@1224|Proteobacteria,2TRSF@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Belongs to the BI1 family ybhL - - ko:K06890 - - - - ko00000 - - - Bax1-I k59_79157_1 519989.ECTPHS_02394 2.86e-35 132.0 COG2377@1|root,COG2377@2|Bacteria,1MV4E@1224|Proteobacteria,1RNTZ@1236|Gammaproteobacteria,1WXXP@135613|Chromatiales 135613|Chromatiales O Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling anmK - 2.7.1.170 ko:K09001 - - - - ko00000,ko01000 - - - AnmK k59_583881_1 1304883.KI912532_gene2335 4.71e-44 158.0 COG0642@1|root,COG2205@2|Bacteria,1MUAK@1224|Proteobacteria,2VJ6W@28216|Betaproteobacteria,2KUEB@206389|Rhodocyclales 206389|Rhodocyclales T Periplasmic domain of Sensor histidine kinase RisS - - 2.7.13.3 ko:K07638 ko02020,ko02026,map02020,map02026 M00445,M00742,M00743 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,RisS_PPD k59_1180398_1 414684.RC1_0381 8.98e-94 293.0 COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2TRC2@28211|Alphaproteobacteria,2JPR7@204441|Rhodospirillales 204441|Rhodospirillales I COG4770 Acetyl propionyl-CoA carboxylase, alpha subunit - - 6.4.1.4 ko:K01968 ko00280,ko01100,map00280,map01100 M00036 R04138 RC00367,RC00942 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_967133_1 1449350.OCH239_17520 3.68e-16 77.4 COG1947@1|root,COG1947@2|Bacteria,1MVU3@1224|Proteobacteria,2TUFV@28211|Alphaproteobacteria,4KMEK@93682|Roseivivax 28211|Alphaproteobacteria F Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol ispE GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515 2.7.1.148 ko:K00919 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05634 RC00002,RC01439 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N k59_967133_2 652103.Rpdx1_1202 3.21e-11 66.6 COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,2TQV5@28211|Alphaproteobacteria,3JTV2@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Tetratricopeptide repeat MA20_42300 - - - - - - - - - - - TPR_16,TPR_19,TPR_2,TPR_6,TPR_7,TPR_8 k59_711493_1 497965.Cyan7822_0441 8.77e-64 211.0 COG2133@1|root,COG2133@2|Bacteria,1G06W@1117|Cyanobacteria,3KJ95@43988|Cyanothece 1117|Cyanobacteria G Glucose / Sorbosone dehydrogenase - - - - - - - - - - - - GSDH k59_154854_1 479433.Caci_0038 4.18e-19 91.3 COG0515@1|root,COG0515@2|Bacteria,2GJ1J@201174|Actinobacteria 201174|Actinobacteria KLT serine threonine protein kinase pknB GO:0000270,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008047,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0010698,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0022603,GO:0022604,GO:0030145,GO:0030203,GO:0030234,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032091,GO:0034645,GO:0036211,GO:0040007,GO:0042304,GO:0042546,GO:0042802,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043388,GO:0043393,GO:0043412,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046872,GO:0046890,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051055,GO:0051098,GO:0051099,GO:0051100,GO:0051101,GO:0051128,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0075136,GO:0080090,GO:0098772,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase k59_154863_1 1347392.CCEZ01000010_gene2408 5.95e-46 165.0 COG1001@1|root,COG1001@2|Bacteria,1TP84@1239|Firmicutes,247KN@186801|Clostridia,36DDA@31979|Clostridiaceae 186801|Clostridia F Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family ade - 3.5.4.2 ko:K01486 ko00230,ko01100,map00230,map01100 - R01244 RC00477 ko00000,ko00001,ko01000 - - - Adenine_deam_C,Amidohydro_1 k59_669533_1 1382306.JNIM01000001_gene4220 1.09e-20 95.9 COG1070@1|root,COG1070@2|Bacteria,2G6JV@200795|Chloroflexi 200795|Chloroflexi G Carbohydrate kinase - - - - - - - - - - - - MutL k59_924796_1 314271.RB2654_22053 1.53e-23 103.0 COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,2TVQS@28211|Alphaproteobacteria 28211|Alphaproteobacteria P ABC-type Fe3 transport system permease component - - - ko:K02011 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - BPD_transp_1 k59_76636_1 502025.Hoch_1452 4.42e-07 57.0 COG2885@1|root,COG2885@2|Bacteria,1R8DG@1224|Proteobacteria,42NGC@68525|delta/epsilon subdivisions,2WMAP@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Belongs to the ompA family - - - ko:K03286 - - - - ko00000,ko02000 1.B.6 - - OmpA,Phenol_MetA_deg,TSP_3,VWA k59_540984_1 1121129.KB903359_gene1975 1.28e-05 48.5 COG2267@1|root,COG2267@2|Bacteria,4NHI2@976|Bacteroidetes,2FNPW@200643|Bacteroidia,22WWI@171551|Porphyromonadaceae 976|Bacteroidetes I Alpha/beta hydrolase family - - - - - - - - - - - - Hydrolase_4 k59_540984_2 159450.NH14_12920 3.41e-50 176.0 COG3387@1|root,COG3387@2|Bacteria,1MV08@1224|Proteobacteria,2VHBN@28216|Betaproteobacteria,1K0YU@119060|Burkholderiaceae 28216|Betaproteobacteria G PFAM glycoside hydrolase 15-related - - - - - - - - - - - - Glyco_hydro_15 k59_835352_1 690850.Desaf_2364 6.61e-72 236.0 28HC9@1|root,2Z7P5@2|Bacteria,1R4BH@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_1009608_1 1449076.JOOE01000004_gene304 1.58e-84 262.0 COG2224@1|root,COG2224@2|Bacteria,1MWIF@1224|Proteobacteria,2TU0Q@28211|Alphaproteobacteria,2K0CD@204457|Sphingomonadales 204457|Sphingomonadales C Isocitrate lyase aceA - 4.1.3.1 ko:K01637 ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200 M00012 R00479 RC00311,RC00313 ko00000,ko00001,ko00002,ko01000 - - - ICL k59_581347_1 926569.ANT_01450 8.27e-54 172.0 COG2236@1|root,COG2236@2|Bacteria,2G6Y5@200795|Chloroflexi 200795|Chloroflexi F Phosphoribosyl transferase domain - - - ko:K07101 - - - - ko00000 - - - Pribosyltran k59_581347_2 479434.Sthe_3231 6.21e-12 66.2 COG0345@1|root,COG0345@2|Bacteria,2G5QD@200795|Chloroflexi,27Y1C@189775|Thermomicrobia 189775|Thermomicrobia E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline proC - 1.5.1.2 ko:K00286 ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230 M00015 R01248,R01251,R03291,R03293 RC00054,RC00083 ko00000,ko00001,ko00002,ko01000 - - - F420_oxidored,P5CR_dimer k59_243207_1 1144319.PMI16_03565 2.95e-104 317.0 COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,2VIFK@28216|Betaproteobacteria,472MS@75682|Oxalobacteraceae 28216|Betaproteobacteria H Probable molybdopterin binding domain moeA1 - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N k59_1180549_1 1123234.AUKI01000013_gene1549 1.75e-21 97.8 COG4301@1|root,COG4301@2|Bacteria,4NEFC@976|Bacteroidetes,1HYNH@117743|Flavobacteriia 976|Bacteroidetes S Methyltransferase egtD - - - - - - - - - - - Methyltransf_33 k59_632500_1 1095769.CAHF01000011_gene2083 2.75e-62 205.0 COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,2VING@28216|Betaproteobacteria,472K7@75682|Oxalobacteraceae 28216|Betaproteobacteria D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase tig GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K03545 - - - - ko00000 - - - FKBP_C,Trigger_C,Trigger_N k59_711651_1 1294143.H681_15735 9.55e-23 92.8 COG2755@1|root,COG2755@2|Bacteria,1RCXZ@1224|Proteobacteria,1S3QU@1236|Gammaproteobacteria 1236|Gammaproteobacteria E COG2755 Lysophospholipase L1 and related esterases tesA GO:0003674,GO:0003824,GO:0004620,GO:0004622,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016289,GO:0016290,GO:0016298,GO:0016787,GO:0016788,GO:0016790,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0042802,GO:0043170,GO:0044238,GO:0044464,GO:0047617,GO:0052689,GO:0071704,GO:0140096,GO:1901564 3.1.1.5 ko:K10804 ko01040,map01040 - - - ko00000,ko00001,ko01000,ko01004 - - iECED1_1282.ECED1_0521,iLF82_1304.LF82_2242,iNRG857_1313.NRG857_02365 Lipase_GDSL_2 k59_711651_2 1112217.PPL19_09286 2.2e-30 119.0 COG4324@1|root,COG4324@2|Bacteria,1N0FE@1224|Proteobacteria 1224|Proteobacteria S Aminopeptidase - - - - - - - - - - - - Aminopep k59_1059147_1 977880.RALTA_A0051 3.6e-74 237.0 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2VIG3@28216|Betaproteobacteria,1K0ET@119060|Burkholderiaceae 28216|Betaproteobacteria J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_1223357_1 1469245.JFBG01000057_gene2376 2.74e-08 56.6 COG4665@1|root,COG4665@2|Bacteria,1RG47@1224|Proteobacteria,1S3PZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q TRAP-type mannitol chloroaromatic compound transport system small permease component - - - - - - - - - - - - DctQ k59_1223357_2 331869.BAL199_27031 1.23e-83 262.0 COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria,4BPBH@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria Q COG4664 TRAP-type mannitol chloroaromatic compound transport system, large permease component - - - - - - - - - - - - DctM k59_1308556_1 550540.Fbal_0378 6.21e-121 355.0 COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,1RMDH@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III hemE GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006536,GO:0006725,GO:0006778,GO:0006779,GO:0006780,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009064,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019353,GO:0019438,GO:0019752,GO:0033013,GO:0033014,GO:0033526,GO:0034641,GO:0042168,GO:0042440,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046394,GO:0046483,GO:0046501,GO:0046502,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - iPC815.YPO3734,iSBO_1134.SBO_4018 URO-D k59_1009717_1 1287276.X752_26545 7.99e-44 155.0 COG0500@1|root,COG2226@2|Bacteria,1R6ZI@1224|Proteobacteria,2TRC6@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q ubiE/COQ5 methyltransferase family - - - - - - - - - - - - Methyltransf_11,Methyltransf_25 k59_800978_1 522306.CAP2UW1_0458 9.48e-68 228.0 COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,2VP2B@28216|Betaproteobacteria 28216|Betaproteobacteria V Abc transporter - - - ko:K11004 ko02010,ko03070,ko05133,map02010,map03070,map05133 M00325,M00575 - - ko00000,ko00001,ko00002,ko02000,ko02044 3.A.1.109.1,3.A.1.109.2 - - ABC_membrane,ABC_tran k59_1009749_1 1198452.Jab_1c03440 1.7e-75 236.0 COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,2VHRM@28216|Betaproteobacteria,473XU@75682|Oxalobacteraceae 28216|Betaproteobacteria U Belongs to the binding-protein-dependent transport system permease family - - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_835524_1 1278309.KB907109_gene3230 2.69e-13 78.2 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RME8@1236|Gammaproteobacteria,1XIG3@135619|Oceanospirillales 135619|Oceanospirillales O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_331507_1 671143.DAMO_1674 9.47e-26 107.0 COG2801@1|root,COG2801@2|Bacteria 2|Bacteria L transposition - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve,rve_3 k59_374836_1 420324.KI912027_gene316 1.22e-84 261.0 COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,2TS6X@28211|Alphaproteobacteria,1JX9I@119045|Methylobacteriaceae 28211|Alphaproteobacteria S Putative transposase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_112823_1 1123393.KB891327_gene424 1.59e-87 265.0 COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,2VJIA@28216|Betaproteobacteria,1KS4D@119069|Hydrogenophilales 119069|Hydrogenophilales Q ABC transporter - - - - - - - - - - - - ABC_tran k59_1009809_1 1123393.KB891329_gene998 4.16e-41 150.0 COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,2VHWM@28216|Betaproteobacteria,1KSH7@119069|Hydrogenophilales 119069|Hydrogenophilales EP Binding-protein-dependent transport system inner membrane component - - - - - - - - - - - - BPD_transp_1 k59_1009809_2 754476.Q7A_2181 7.05e-80 246.0 COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,1RNJ1@1236|Gammaproteobacteria,45ZR0@72273|Thiotrichales 72273|Thiotrichales EP PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_669845_1 467661.RKLH11_3631 5.35e-62 201.0 COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,1PBHA@1224|Proteobacteria,2TRQF@28211|Alphaproteobacteria,3ZI18@58840|unclassified Rhodobacteraceae 28211|Alphaproteobacteria L L COG2801 Transposase and inactivated derivatives - - - - - - - - - - - - HTH_32,rve,rve_3 k59_669845_2 504472.Slin_2663 8.49e-32 115.0 COG2963@1|root,COG2963@2|Bacteria,4NQ94@976|Bacteroidetes,47T18@768503|Cytophagia 976|Bacteroidetes L PFAM transposase IS3 IS911 family protein - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 k59_1180758_2 1122604.JONR01000009_gene2347 2.93e-42 149.0 COG0671@1|root,COG0671@2|Bacteria,1RFUF@1224|Proteobacteria,1S722@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Phosphoesterase, PA-phosphatase related - - - - - - - - - - - - PAP2 k59_754414_1 1382306.JNIM01000001_gene4028 1.56e-36 135.0 COG0506@1|root,COG0506@2|Bacteria,2G6B6@200795|Chloroflexi 200795|Chloroflexi C Proline dehydrogenase - - - ko:K00318 ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130 - R10507 RC00083 ko00000,ko00001,ko01000 - - - Pro_dh k59_967498_1 111781.Lepto7376_0248 1.27e-90 273.0 COG3541@1|root,COG3541@2|Bacteria,1G3R1@1117|Cyanobacteria,1H74A@1150|Oscillatoriales 1117|Cyanobacteria S PFAM Nucleotidyltransferase - - - ko:K07074 - - - - ko00000 - - - Nuc-transf k59_1266121_1 1051632.TPY_3156 3.98e-57 196.0 COG3328@1|root,COG3328@2|Bacteria,1V116@1239|Firmicutes,24D8K@186801|Clostridia 186801|Clostridia L Transposase, Mutator family - - - - - - - - - - - - Transposase_mut k59_1223535_1 1173023.KE650771_gene5241 1.21e-13 79.3 COG2202@1|root,COG2203@1|root,COG2905@1|root,COG4251@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2905@2|Bacteria,COG4251@2|Bacteria,1GHCI@1117|Cyanobacteria,1JMXN@1189|Stigonemataceae 1117|Cyanobacteria T Domain in cystathionine beta-synthase and other proteins. - - 2.1.1.80,3.1.1.61 ko:K13924 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CBS,CheB_methylest,CheR,CheR_N,GAF,GGDEF,HATPase_c,HisKA,PAS,PAS_10,PAS_3,PAS_4,PAS_8,PAS_9 k59_1266138_1 1115515.EV102420_02_03050 2.13e-103 309.0 COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,1RNV6@1236|Gammaproteobacteria,3XP3M@561|Escherichia 1236|Gammaproteobacteria H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme metK GO:0000096,GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004478,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006556,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009069,GO:0009108,GO:0009116,GO:0009119,GO:0009987,GO:0016740,GO:0016765,GO:0017076,GO:0017144,GO:0019752,GO:0030554,GO:0030955,GO:0031420,GO:0032553,GO:0032555,GO:0032559,GO:0033353,GO:0034641,GO:0035639,GO:0036094,GO:0042278,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0046872,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901576,GO:1901605,GO:1901657 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - iJN746.PP_4967,iYL1228.KPN_03375 S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N k59_200233_1 228410.NE1603 1.28e-27 104.0 COG2165@1|root,COG2165@2|Bacteria,1RGZZ@1224|Proteobacteria,2VSZ6@28216|Betaproteobacteria,3735R@32003|Nitrosomonadales 28216|Betaproteobacteria U Prokaryotic N-terminal methylation motif - - - ko:K02456 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl k59_200233_2 265072.Mfla_2412 6.54e-38 131.0 COG2165@1|root,COG2165@2|Bacteria,1N1QJ@1224|Proteobacteria,2VTYJ@28216|Betaproteobacteria,2KMZA@206350|Nitrosomonadales 206350|Nitrosomonadales NU Prokaryotic N-terminal methylation motif - - - ko:K02456 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl,T2SSG k59_1101718_2 402881.Plav_2967 2.66e-16 80.1 COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,2TRQ2@28211|Alphaproteobacteria,1JP3A@119043|Rhodobiaceae 28211|Alphaproteobacteria CP Proton-conducting membrane transporter nuoN2 - 1.6.5.3 ko:K00343,ko:K05568 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000,ko02000 2.A.63.1,2.A.63.2,3.D.1 - - Proton_antipo_M k59_1101729_1 90814.KL370891_gene746 2.81e-61 212.0 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,1RNK8@1236|Gammaproteobacteria,460U8@72273|Thiotrichales 72273|Thiotrichales Q PFAM Hemolysin-type calcium-binding repeat (2 copies) - - - - - - - - - - - - HCBP_related,He_PIG,HemolysinCabind k59_200328_1 1238182.C882_4193 2.63e-31 117.0 COG2867@1|root,COG2867@2|Bacteria,1PPRM@1224|Proteobacteria,2UJ52@28211|Alphaproteobacteria,2JU9G@204441|Rhodospirillales 204441|Rhodospirillales I Polyketide cyclase / dehydrase and lipid transport - - - ko:K18588 - - - - ko00000 - - - Polyketide_cyc k59_498873_1 323848.Nmul_A1150 1.33e-74 251.0 COG0493@1|root,COG0543@1|root,COG0493@2|Bacteria,COG0543@2|Bacteria,1PV5D@1224|Proteobacteria,2WB3J@28216|Betaproteobacteria,37281@32003|Nitrosomonadales 28216|Betaproteobacteria CEH PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Pyr_redox_2 k59_375080_1 398578.Daci_5421 6.02e-36 139.0 COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,2VHHA@28216|Betaproteobacteria,4AA94@80864|Comamonadaceae 28216|Betaproteobacteria L May be involved in recombinational repair of damaged DNA recN - - ko:K03631 - - - - ko00000,ko03400 - - - SMC_N k59_801286_1 744980.TRICHSKD4_0365 1.68e-48 162.0 COG4665@1|root,COG4665@2|Bacteria,1QV7S@1224|Proteobacteria,2TWCP@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q COG4665 TRAP-type mannitol chloroaromatic compound transport system, small permease component - - - - - - - - - - - - DctQ k59_1180967_1 420324.KI911965_gene1316 5.81e-52 184.0 COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2TQY9@28211|Alphaproteobacteria 28211|Alphaproteobacteria S transport system fused permease components - - - - - - - - - - - - DUF3394,DctM k59_1134325_1 882.DVU_3014 1.07e-36 143.0 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,42MEI@68525|delta/epsilon subdivisions,2WJEG@28221|Deltaproteobacteria,2M88F@213115|Desulfovibrionales 28221|Deltaproteobacteria E TIGRFAM asparagine synthase (glutamine-hydrolyzing) - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_1223779_1 1198232.CYCME_0104 2.46e-69 233.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RPIP@1236|Gammaproteobacteria,46225@72273|Thiotrichales 72273|Thiotrichales S MMPL family - - - ko:K07003 - - - - ko00000 - - - MMPL k59_1355712_1 1235457.C404_15510 6.74e-74 236.0 COG0625@1|root,COG3832@1|root,COG0625@2|Bacteria,COG3832@2|Bacteria,1RC4Y@1224|Proteobacteria,2VW3S@28216|Betaproteobacteria,1KH88@119060|Burkholderiaceae 28216|Betaproteobacteria O Glutathione S-transferase gstF - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - AHSA1,GST_C,GST_N,GST_N_3 k59_967817_1 582744.Msip34_1942 1.79e-35 132.0 COG0683@1|root,COG0683@2|Bacteria,1MV5T@1224|Proteobacteria,2VI33@28216|Betaproteobacteria,2KM8I@206350|Nitrosomonadales 206350|Nitrosomonadales E Periplasmic binding protein - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_1065547_1 1123072.AUDH01000007_gene1132 1.1e-40 154.0 COG1042@1|root,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2TR24@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG1042 Acyl-CoA synthetase (NDP forming) - - - - - - - - - - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig k59_37320_1 748247.AZKH_4036 2.35e-25 110.0 COG0653@1|root,COG0653@2|Bacteria,1QZ1G@1224|Proteobacteria,2VQGH@28216|Betaproteobacteria,2KWYF@206389|Rhodocyclales 1224|Proteobacteria U Putative outer membrane beta-barrel porin, MtrB/PioB - - - - - - - - - - - - MtrB_PioB k59_118199_1 640511.BC1002_1959 2.86e-47 163.0 COG5429@1|root,COG5429@2|Bacteria,1MW6R@1224|Proteobacteria,2VSC6@28216|Betaproteobacteria,1K582@119060|Burkholderiaceae 28216|Betaproteobacteria S Protein of unknown function (DUF1223) - - - - - - - - - - - - DUF1223 k59_638829_1 999541.bgla_1g32410 1.16e-10 61.2 COG0372@1|root,COG0372@2|Bacteria,1MXFW@1224|Proteobacteria,2VIHZ@28216|Betaproteobacteria,1K0MU@119060|Burkholderiaceae 28216|Betaproteobacteria C citrate synthase - - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt,HTH_17 k59_638829_2 925409.KI911562_gene1525 1.38e-47 166.0 COG1232@1|root,COG1232@2|Bacteria,4NJNP@976|Bacteroidetes 976|Bacteroidetes H Flavin containing amine oxidoreductase - - - - - - - - - - - - Amino_oxidase,NAD_binding_8 k59_160438_1 83406.HDN1F_22290 8.13e-45 165.0 COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,1RMRN@1236|Gammaproteobacteria,1J54G@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate purL GO:0000166,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006520,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009064,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016874,GO:0016879,GO:0016884,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - iECH74115_1262.ECH74115_3792,iECO111_1330.ECO111_3283,iECSP_1301.ECSP_3501,iECs_1301.ECs3423,iG2583_1286.G2583_3088,iJN746.PP_1037,ic_1306.c3080 AIRS_C,GATase_5 k59_1271386_1 388051.AUFE01000012_gene2942 7.66e-69 213.0 COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,2VR7N@28216|Betaproteobacteria,1KH6M@119060|Burkholderiaceae 28216|Betaproteobacteria U general secretion pathway protein G gspG - - ko:K02456 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl,T2SSG k59_419446_1 1469245.JFBG01000008_gene769 1.16e-06 55.8 2DM5E@1|root,31SVN@2|Bacteria,1MYKR@1224|Proteobacteria,1SF2N@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF4340) - - - - - - - - - - - - DUF4340 k59_380178_1 28115.HR11_04780 6.35e-30 121.0 COG3385@1|root,COG3385@2|Bacteria,4NHKV@976|Bacteroidetes,2FPZQ@200643|Bacteroidia,22Y2D@171551|Porphyromonadaceae 976|Bacteroidetes L transposase, IS4 - - - - - - - - - - - - DDE_Tnp_1,DUF4372 k59_1107753_1 565045.NOR51B_2502 6.76e-91 281.0 COG2978@1|root,COG2978@2|Bacteria,1MUJ1@1224|Proteobacteria,1RMAI@1236|Gammaproteobacteria,1J7IF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H AbgT putative transporter family abgT - - ko:K12942 - - - - ko00000 - - - ABG_transport k59_972730_1 1223521.BBJX01000002_gene2860 4.29e-28 114.0 COG0843@1|root,COG0843@2|Bacteria,1R57U@1224|Proteobacteria,2VJ1N@28216|Betaproteobacteria,4AHFT@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM Cytochrome c oxidase, subunit I cbaA - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 k59_717151_1 580332.Slit_0761 1.74e-92 301.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,2VIF3@28216|Betaproteobacteria,44VNH@713636|Nitrosomonadales 28216|Betaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_675133_1 1229909.NSED_04335 4.33e-125 369.0 COG0034@1|root,arCOG00093@2157|Archaea,41S7N@651137|Thaumarchaeota 651137|Thaumarchaeota F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF - 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase_6,Pribosyltran k59_806351_2 1286170.RORB6_10035 1.49e-29 111.0 COG0791@1|root,COG0791@2|Bacteria,1MYEI@1224|Proteobacteria,1S8J6@1236|Gammaproteobacteria 1236|Gammaproteobacteria M NlpC/P60 family - - - - - - - - - - - - NLPC_P60 k59_1313968_1 1454004.AW11_01130 3.62e-71 226.0 COG2370@1|root,COG2370@2|Bacteria,1MV6Z@1224|Proteobacteria,2VM5U@28216|Betaproteobacteria 28216|Betaproteobacteria O HupE / UreJ protein - - - - - - - - - - - - HupE_UreJ_2 k59_461525_1 765420.OSCT_2454 3.63e-94 295.0 COG1028@1|root,COG3347@1|root,COG1028@2|Bacteria,COG3347@2|Bacteria 2|Bacteria IQ Class II Aldolase and Adducin N-terminal domain - - - - - - - - - - - - Aldolase_II,adh_short,adh_short_C2 k59_1107819_1 62928.azo0164 9.36e-50 164.0 COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,2VIT4@28216|Betaproteobacteria,2KUNU@206389|Rhodocyclales 206389|Rhodocyclales K COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain phoB - - ko:K07657 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_930508_1 1031711.RSPO_c00382 1.85e-158 451.0 COG3185@1|root,COG3185@2|Bacteria,1MUVZ@1224|Proteobacteria,2VJCK@28216|Betaproteobacteria,1K3GI@119060|Burkholderiaceae 28216|Betaproteobacteria C 4-Hydroxyphenylpyruvate dioxygenase hppD - 1.13.11.27 ko:K00457 ko00130,ko00350,ko00360,ko01100,map00130,map00350,map00360,map01100 M00044 R01372,R02521 RC00505,RC00738 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Glyoxalase,Glyoxalase_5 k59_759685_2 1218075.BAYA01000001_gene315 9.67e-65 206.0 COG1235@1|root,COG1235@2|Bacteria,1R5N4@1224|Proteobacteria,2VKSE@28216|Betaproteobacteria,1K1VX@119060|Burkholderiaceae 28216|Betaproteobacteria S beta-lactamase - - - - - - - - - - - - Lactamase_B_2 k59_380274_1 631454.N177_2917 6.35e-96 295.0 COG0174@1|root,COG0174@2|Bacteria,1MU6V@1224|Proteobacteria,2TRCP@28211|Alphaproteobacteria,1JNDM@119043|Rhodobiaceae 28211|Alphaproteobacteria E Glutamine synthetase, catalytic domain glnA1 - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C k59_82300_1 1463926.JOCA01000027_gene3152 1.66e-31 127.0 COG0411@1|root,COG0559@1|root,COG4177@1|root,COG0411@2|Bacteria,COG0559@2|Bacteria,COG4177@2|Bacteria,2GJHR@201174|Actinobacteria 201174|Actinobacteria E Belongs to the binding-protein-dependent transport system permease family - - - ko:K01997,ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BPD_transp_2 k59_82300_2 1458275.AZ34_07625 1.52e-07 53.1 COG4177@1|root,COG4177@2|Bacteria,1NPII@1224|Proteobacteria,2VNRM@28216|Betaproteobacteria,4AAJ7@80864|Comamonadaceae 28216|Betaproteobacteria P Belongs to the binding-protein-dependent transport system permease family - - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_380279_1 279714.FuraDRAFT_2797 4.42e-14 72.8 COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,2VH3W@28216|Betaproteobacteria,2KPZT@206351|Neisseriales 206351|Neisseriales LU DNA recombination-mediator protein A dprA - - ko:K04096 - - - - ko00000 - - - DNA_processg_A k59_380279_2 1123487.KB892857_gene2535 9.78e-14 70.1 COG2922@1|root,COG2922@2|Bacteria,1RD5F@1224|Proteobacteria,2VRJF@28216|Betaproteobacteria,2KWJJ@206389|Rhodocyclales 206389|Rhodocyclales S Belongs to the Smg family smg - - ko:K03747 - - - - ko00000 - - - DUF494 k59_279462_1 1437824.BN940_15161 9.78e-87 283.0 COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,2VHCS@28216|Betaproteobacteria,3T1IE@506|Alcaligenaceae 28216|Betaproteobacteria L DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase dnaE2 - 2.7.7.7 ko:K14162 - - - - ko00000,ko01000,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_1304284_2 264198.Reut_A2795 1.09e-51 170.0 COG1346@1|root,COG1346@2|Bacteria,1MV81@1224|Proteobacteria,2VH4N@28216|Betaproteobacteria,1K2SA@119060|Burkholderiaceae 28216|Betaproteobacteria M PFAM LrgB family protein lrgB - - - - - - - - - - - LrgB k59_494917_1 443598.AUFA01000044_gene4724 2.22e-55 184.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,3JR1M@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L PFAM transposase IS116 IS110 IS902 family - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_28171_1 1166130.H650_01740 5.06e-22 95.5 COG2095@1|root,COG2095@2|Bacteria,1MX5T@1224|Proteobacteria,1RPZ3@1236|Gammaproteobacteria,3X18T@547|Enterobacter 1236|Gammaproteobacteria U UPF0056 inner membrane protein ychE GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K05595 - - - - ko00000,ko02000 2.A.95.1 - - MarC k59_797381_2 572477.Alvin_0769 3.89e-40 148.0 COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,1RMCI@1236|Gammaproteobacteria,1WXIB@135613|Chromatiales 135613|Chromatiales L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parE - - ko:K02622 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_239045_1 1158756.AQXQ01000012_gene1999 7.52e-46 150.0 COG1146@1|root,COG1146@2|Bacteria,1R4GP@1224|Proteobacteria,1RXXW@1236|Gammaproteobacteria,1WVWW@135613|Chromatiales 135613|Chromatiales C reductase beta subunit - - 1.8.99.2 ko:K00395 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00596 R00860,R04927,R08553 RC00007,RC01239,RC02862 ko00000,ko00001,ko00002,ko01000 - - - APS-reductase_C,Fer4,Fer4_9 k59_239045_2 1266914.ATUK01000014_gene2206 2e-66 218.0 COG1053@1|root,COG1053@2|Bacteria,1NZBR@1224|Proteobacteria,1RZ0U@1236|Gammaproteobacteria,1WW7B@135613|Chromatiales 135613|Chromatiales C reductase, alpha subunit - - 1.8.99.2 ko:K00394 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00596 R00860,R04927,R08553 RC00007,RC01239,RC02862 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_1097284_1 861299.J421_1663 8.16e-69 221.0 COG3191@1|root,COG3191@2|Bacteria,1ZT47@142182|Gemmatimonadetes 142182|Gemmatimonadetes EQ Peptidase family S58 - - 3.4.11.19 ko:K01266 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S58 k59_665462_1 1410608.JNKX01000013_gene751 1.05e-16 84.7 COG0841@1|root,COG0841@2|Bacteria,4NDZG@976|Bacteroidetes,2FM3B@200643|Bacteroidia,4AMAT@815|Bacteroidaceae 976|Bacteroidetes V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family czcA - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_537617_1 876269.ARWA01000001_gene1160 3.62e-43 159.0 COG0457@1|root,COG2227@1|root,COG3914@1|root,COG0457@2|Bacteria,COG2227@2|Bacteria,COG3914@2|Bacteria,1MVMG@1224|Proteobacteria,2TRVB@28211|Alphaproteobacteria,3NAKJ@45404|Beijerinckiaceae 28211|Alphaproteobacteria HO Glycosyl transferase family 41 - - - - - - - - - - - - Glyco_transf_41,Methyltransf_23,TPR_1,TPR_11,TPR_16,TPR_2,TPR_8 k59_109158_1 399739.Pmen_0912 3.1e-51 172.0 COG0313@1|root,COG0313@2|Bacteria,1MU0E@1224|Proteobacteria,1RM7U@1236|Gammaproteobacteria,1YDF2@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA rsmI GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070677,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.198 ko:K07056 - - - - ko00000,ko01000,ko03009 - - - TP_methylase k59_1097348_1 522306.CAP2UW1_4068 1.71e-86 283.0 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,2VH5B@28216|Betaproteobacteria,1KQ6A@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria H Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell glnE - 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_151547_1 187272.Mlg_1415 4.05e-22 98.2 COG0470@1|root,COG0470@2|Bacteria,1MY1W@1224|Proteobacteria,1RNYA@1236|Gammaproteobacteria,1WW0S@135613|Chromatiales 135613|Chromatiales L DNA polymerase III, delta' - - 2.7.7.7 ko:K02341 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNApol3-delta_C k59_1262515_1 754476.Q7A_741 2.31e-83 269.0 COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RN8P@1236|Gammaproteobacteria,46054@72273|Thiotrichales 72273|Thiotrichales G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties - - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - Phosphorylase k59_875555_1 1502852.FG94_03772 1.44e-107 337.0 COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,2VIEJ@28216|Betaproteobacteria,473U5@75682|Oxalobacteraceae 28216|Betaproteobacteria J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1,zf-FPG_IleRS k59_1006380_1 626887.J057_09836 1.1e-108 330.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,1RN7X@1236|Gammaproteobacteria,4665Q@72275|Alteromonadaceae 1236|Gammaproteobacteria I COG1960 Acyl-CoA dehydrogenases aidB GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003995,GO:0005488,GO:0005515,GO:0006355,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008470,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016491,GO:0016627,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0033554,GO:0042802,GO:0043565,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0055114,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - ko:K09456 - - - - ko00000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M k59_28386_1 549.BW31_01512 4.64e-11 68.2 COG3501@1|root,COG3501@2|Bacteria,1MU7Q@1224|Proteobacteria,1RMZS@1236|Gammaproteobacteria,3VYXD@53335|Pantoea 1236|Gammaproteobacteria NU Rhs Element Vgr Protein - - - ko:K11904 ko03070,map03070 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - Glucosaminidase,Gp5_C,Phage_GPD k59_797583_1 1191523.MROS_0727 4.29e-42 157.0 COG0436@1|root,COG0436@2|Bacteria 2|Bacteria E Aminotransferase - - - ko:K21572 - - - - ko00000,ko02000 8.A.46.1,8.A.46.3 - - SusD-like_3,SusD_RagB k59_151641_1 330214.NIDE0888 6.7e-71 233.0 COG3170@1|root,COG3170@2|Bacteria 2|Bacteria NU translation initiation factor activity wzi - - - - - - - - - - - Caps_assemb_Wzi,PAP2 k59_239289_1 395495.Lcho_4123 4.69e-83 269.0 COG3303@1|root,COG3303@2|Bacteria,1PEVM@1224|Proteobacteria,2VMWI@28216|Betaproteobacteria,1KN2G@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Doubled CXXCH motif (Paired_CXXCH_1) - - - - - - - - - - - - Paired_CXXCH_1 k59_1304557_1 522306.CAP2UW1_4021 5.37e-52 174.0 COG1385@1|root,COG1385@2|Bacteria,1MXCU@1224|Proteobacteria,2VJS2@28216|Betaproteobacteria,1KQ0U@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit rsmE - 2.1.1.193 ko:K09761 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_RNA k59_371423_1 1380346.JNIH01000036_gene287 1.56e-17 87.4 COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2GMPZ@201174|Actinobacteria 201174|Actinobacteria KLT serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase,TPR_10,TPR_12 k59_963978_1 580332.Slit_1289 2.14e-81 269.0 COG0642@1|root,COG0784@1|root,COG2198@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria 28216|Betaproteobacteria T Histidine kinase - - 2.7.13.3 ko:K10715 ko02020,ko02024,map02020,map02024 M00517 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - CHASE2,HATPase_c,HisKA,Hpt,Response_reg k59_797649_1 269796.Rru_A0418 7.68e-64 207.0 COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,2TR32@28211|Alphaproteobacteria,2JP9A@204441|Rhodospirillales 204441|Rhodospirillales I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP fabF - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_328094_1 887898.HMPREF0551_1076 1.46e-95 291.0 COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,2VH7Y@28216|Betaproteobacteria,1K1WM@119060|Burkholderiaceae 28216|Betaproteobacteria F Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno GO:0000015,GO:0000287,GO:0003674,GO:0003824,GO:0004634,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005856,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043167,GO:0043169,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046872,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902494 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N k59_1097616_1 414684.RC1_2604 3.23e-57 201.0 COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,2TQJZ@28211|Alphaproteobacteria,2JPMW@204441|Rhodospirillales 204441|Rhodospirillales L Belongs to the helicase family. UvrD subfamily addA - 3.6.4.12 ko:K16898 - - - - ko00000,ko01000,ko03400 - - - PDDEXK_1,UvrD-helicase,UvrD_C k59_1177342_1 92637.XP_007815504.1 1.12e-31 127.0 COG2072@1|root,KOG1399@2759|Eukaryota,38CJ1@33154|Opisthokonta,3NWP7@4751|Fungi,3QN2K@4890|Ascomycota,2138C@147550|Sordariomycetes,3TGPJ@5125|Hypocreales,3G1XK@34397|Clavicipitaceae 4751|Fungi Q Pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - FAD_binding_3,FMO-like,Pyr_redox_2,Pyr_redox_3 k59_1220085_1 251221.35211453 2.72e-65 216.0 COG1174@1|root,COG1732@1|root,COG1174@2|Bacteria,COG1732@2|Bacteria,1G1ZS@1117|Cyanobacteria 1117|Cyanobacteria M Substrate binding domain of ABC-type glycine betaine transport system - - - ko:K05845,ko:K05846 ko02010,map02010 M00209 - - ko00000,ko00001,ko00002,ko02000 3.A.1.12 - - BPD_transp_1,OpuAC k59_1006522_1 1033730.CAHG01000016_gene331 3.45e-36 137.0 COG0334@1|root,COG0334@2|Bacteria,2GKXG@201174|Actinobacteria,4DTZN@85009|Propionibacteriales 201174|Actinobacteria E Belongs to the Glu Leu Phe Val dehydrogenases family gdhA - 1.4.1.3 ko:K00261 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_797715_1 794903.OPIT5_13605 1.1e-33 134.0 COG3210@1|root,COG3420@1|root,COG3210@2|Bacteria,COG3420@2|Bacteria,46UU9@74201|Verrucomicrobia,3K9Q3@414999|Opitutae 414999|Opitutae U haemagglutination activity domain - - - - - - - - - - - - Haemagg_act k59_1220097_1 1133850.SHJG_8434 4.05e-09 58.9 COG2124@1|root,COG2124@2|Bacteria,2GJ8V@201174|Actinobacteria 201174|Actinobacteria Q cytochrome p450 - - - - - - - - - - - - p450 k59_1220097_2 1123367.C666_07110 9.2e-24 95.9 COG5490@1|root,COG5490@2|Bacteria,1R4SV@1224|Proteobacteria,2VQP2@28216|Betaproteobacteria,2KW96@206389|Rhodocyclales 206389|Rhodocyclales S Phasin protein - - - - - - - - - - - - Phasin_2 k59_1177367_2 640081.Dsui_1333 4.15e-21 86.7 COG1664@1|root,COG1664@2|Bacteria,1MZN0@1224|Proteobacteria,2VTZQ@28216|Betaproteobacteria,2KWWR@206389|Rhodocyclales 206389|Rhodocyclales M Integral membrane protein CcmA involved in cell shape determination - - - - - - - - - - - - Bactofilin k59_410184_1 105559.Nwat_1862 1.56e-65 220.0 COG1506@1|root,COG1506@2|Bacteria,1MUJ3@1224|Proteobacteria,1RRN4@1236|Gammaproteobacteria,1X0CY@135613|Chromatiales 135613|Chromatiales E PFAM peptidase S9 prolyl oligopeptidase active site domain protein - - - - - - - - - - - - PD40,Peptidase_S9 k59_751102_1 443152.MDG893_17142 4.39e-85 259.0 COG1028@1|root,COG1028@2|Bacteria,1MWGC@1224|Proteobacteria,1S1FQ@1236|Gammaproteobacteria,46CHF@72275|Alteromonadaceae 1236|Gammaproteobacteria IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - 1.1.1.159,1.1.1.206 ko:K00076,ko:K08081 ko00121,ko00960,ko01100,ko01110,map00121,map00960,map01100,map01110 - R02832 RC00144 ko00000,ko00001,ko01000 - - - adh_short_C2 k59_578215_1 1123392.AQWL01000005_gene3151 1.4e-49 166.0 COG0484@1|root,COG0484@2|Bacteria,1MUZ4@1224|Proteobacteria,2VHMU@28216|Betaproteobacteria,1KRCW@119069|Hydrogenophilales 119069|Hydrogenophilales O DnaJ molecular chaperone homology domain - - - ko:K05516 - - - - ko00000,ko03036,ko03110 - - - DnaJ,DnaJ_C k59_578215_2 1454004.AW11_03099 7.17e-24 93.6 2DNU9@1|root,32Z5Z@2|Bacteria,1N93E@1224|Proteobacteria,2VWE8@28216|Betaproteobacteria 28216|Betaproteobacteria S MerR HTH family regulatory protein - - - ko:K18997 - - - - ko00000,ko03036 - - - MerR_2 k59_578221_1 640081.Dsui_0130 9.6e-29 114.0 COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,2VIYB@28216|Betaproteobacteria,2KVTV@206389|Rhodocyclales 206389|Rhodocyclales C Malic enzyme - - 1.1.1.40 ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200 M00169,M00172 R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - - Malic_M,PTA_PTB,malic k59_578221_2 153948.NAL212_2196 1.68e-34 129.0 COG1752@1|root,COG1752@2|Bacteria,1PIHH@1224|Proteobacteria,2VHKX@28216|Betaproteobacteria,3722R@32003|Nitrosomonadales 28216|Betaproteobacteria S Patatin-like phospholipase - - - ko:K07001 - - - - ko00000 - - - Patatin k59_921739_1 406817.XNC1_1809 9.55e-22 95.1 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,1RQP7@1236|Gammaproteobacteria 1236|Gammaproteobacteria L reverse transcriptase - - - - - - - - - - - - GIIM,RVT_1 k59_328213_1 1205680.CAKO01000002_gene2879 2.03e-139 399.0 COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,2TQTH@28211|Alphaproteobacteria,2JQJX@204441|Rhodospirillales 204441|Rhodospirillales E Methionine aminopeptidase map - 3.4.11.18 ko:K01265 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 k59_78468_1 1028801.RG1141_PA01940 1.76e-74 234.0 COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,1PBHA@1224|Proteobacteria,2TRQF@28211|Alphaproteobacteria,4BNBQ@82115|Rhizobiaceae 28211|Alphaproteobacteria L COG2801 Transposase and inactivated derivatives - - 2.7.7.49 ko:K00986,ko:K07497 - - - - ko00000,ko01000 - - - HTH_32,rve,rve_3 k59_245019_1 887898.HMPREF0551_2319 6.66e-69 224.0 COG0591@1|root,COG0591@2|Bacteria,1MUBI@1224|Proteobacteria,2VHA8@28216|Betaproteobacteria,1K5EX@119060|Burkholderiaceae 28216|Betaproteobacteria E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family putP - - ko:K14392 - - - - ko00000,ko02000 2.A.21.1 - - SSF k59_33572_1 292415.Tbd_2748 5.94e-79 245.0 COG4261@1|root,COG4261@2|Bacteria,1MVXJ@1224|Proteobacteria,2VHP0@28216|Betaproteobacteria,1KSBD@119069|Hydrogenophilales 119069|Hydrogenophilales S Bacterial lipid A biosynthesis acyltransferase - - - - - - - - - - - - Lip_A_acyltrans k59_284817_1 1440052.EAKF1_ch0381c 1.04e-06 50.1 COG2110@1|root,COG2110@2|Bacteria,1RCWP@1224|Proteobacteria,1S3WJ@1236|Gammaproteobacteria,3XMM8@561|Escherichia 1236|Gammaproteobacteria S Deacetylates O-acetyl-ADP ribose. Down-regulates ribonuclease 3 (RNase III) activity. Acts by interacting directly with the region of the ribonuclease that is required for dimerization activation ymdB GO:0003674,GO:0003824,GO:0004857,GO:0005488,GO:0005515,GO:0008150,GO:0008428,GO:0009892,GO:0010605,GO:0016787,GO:0019213,GO:0019219,GO:0019222,GO:0019899,GO:0030234,GO:0031323,GO:0031324,GO:0032069,GO:0032074,GO:0043086,GO:0043900,GO:0044092,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060698,GO:0060699,GO:0060700,GO:0060701,GO:0060702,GO:0061463,GO:0065007,GO:0065009,GO:0080090,GO:0098772,GO:1900190,GO:1900231 - - - - - - - - - - Macro k59_284817_2 1071679.BG57_08770 4.26e-91 281.0 COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,2VH93@28216|Betaproteobacteria,1K1ZE@119060|Burkholderiaceae 28216|Betaproteobacteria O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA - - ko:K04485 - - - - ko00000,ko03400 - - - AAA_25,ATPase,ChlI,Lon_C k59_755971_1 414684.RC1_0226 3.03e-72 232.0 COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2TTB9@28211|Alphaproteobacteria,2JZIB@204441|Rhodospirillales 204441|Rhodospirillales I Carboxyl transferase domain - - - - - - - - - - - - Carboxyl_trans k59_755971_2 316058.RPB_2107 3.46e-54 188.0 COG1042@1|root,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2TR24@28211|Alphaproteobacteria,3JRT1@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C CoA binding domain - - - ko:K09181 - - - - ko00000 - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig k59_333202_1 867845.KI911784_gene3682 1.97e-75 241.0 COG0364@1|root,COG0364@2|Bacteria,2G5MB@200795|Chloroflexi,374UD@32061|Chloroflexia 32061|Chloroflexia G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone zwf - 1.1.1.363,1.1.1.49 ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008 R00835,R02736,R10907 RC00001,RC00066 ko00000,ko00001,ko00002,ko01000,ko04147 - - - G6PD_C,G6PD_N k59_78522_2 1230476.C207_01154 2.02e-28 108.0 COG3064@1|root,COG3064@2|Bacteria,1MW64@1224|Proteobacteria,2U2QJ@28211|Alphaproteobacteria,3JWQR@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M Belongs to the acetyltransferase family. ArgA subfamily - - - - - - - - - - - - - k59_156798_1 1163617.SCD_n01091 3.64e-113 334.0 COG1940@1|root,COG1940@2|Bacteria,1MU94@1224|Proteobacteria,2VMGT@28216|Betaproteobacteria 28216|Betaproteobacteria GK ROK family nagK - 2.7.1.2,2.7.1.4,2.7.1.59 ko:K00845,ko:K00847,ko:K00884 ko00010,ko00051,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00051,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R00760,R00867,R01201,R01600,R01786,R03920 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - ROK k59_1061255_1 1266925.JHVX01000008_gene368 1.72e-81 261.0 COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,2VHIA@28216|Betaproteobacteria,371S5@32003|Nitrosomonadales 28216|Betaproteobacteria U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas k59_634674_1 1454004.AW11_00093 2.79e-213 601.0 COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,2VHGU@28216|Betaproteobacteria,1KPWF@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B ctaD - 1.10.3.10,1.9.3.1 ko:K02274,ko:K02298 ko00190,ko01100,map00190,map01100 M00155,M00417 R00081,R11335 RC00016,RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.5,3.D.4.6 - - COX1 k59_880139_1 430998.XP_007678154.1 7.34e-39 139.0 KOG1681@1|root,KOG1681@2759|Eukaryota,39QBQ@33154|Opisthokonta,3Q6GW@4751|Fungi,3RPEJ@4890|Ascomycota,203YS@147541|Dothideomycetes,3MKCF@451867|Dothideomycetidae 4751|Fungi I Enoyl-CoA hydratase/isomerase - - - - - - - - - - - - ECH_1 k59_78588_1 225117.XP_009350076.1 1.8e-52 187.0 COG0050@1|root,COG0480@1|root,KOG0460@2759|Eukaryota,KOG0465@2759|Eukaryota,37K55@33090|Viridiplantae,3G82M@35493|Streptophyta,4JJGU@91835|fabids 35493|Streptophyta J Chloroplast-localized elongation factor EF-G involved in protein synthesis in plastids. Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A- site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome - - - - - - - - - - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_1310388_1 570952.ATVH01000011_gene325 1.62e-93 290.0 COG1249@1|root,COG1249@2|Bacteria,1MU2Z@1224|Proteobacteria,2TQS7@28211|Alphaproteobacteria,2JPC2@204441|Rhodospirillales 204441|Rhodospirillales C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family gor - 1.8.1.7 ko:K00383 ko00480,ko04918,map00480,map04918 - R00094,R00115 RC00011 ko00000,ko00001,ko01000 - - - Pyr_redox_2,Pyr_redox_dim k59_634767_1 583355.Caka_1928 1.07e-42 159.0 COG0189@1|root,COG0586@1|root,COG1073@1|root,COG0189@2|Bacteria,COG0586@2|Bacteria,COG1073@2|Bacteria,46UXZ@74201|Verrucomicrobia 74201|Verrucomicrobia HJ SNARE associated Golgi protein - - - - - - - - - - - - SNARE_assoc k59_376636_1 1037409.BJ6T_23810 1.92e-27 109.0 COG0277@1|root,COG0277@2|Bacteria,1MUPW@1224|Proteobacteria,2TUNK@28211|Alphaproteobacteria,3JSHP@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Berberine and berberine like - - - - - - - - - - - - BBE,FAD_binding_4 k59_376636_2 189753.AXAS01000009_gene6403 8.36e-53 169.0 COG3686@1|root,COG3686@2|Bacteria 2|Bacteria S Membrane - - - - - - - - - - - - MAPEG k59_78638_1 999541.bgla_2g21880 3.62e-67 220.0 COG0662@1|root,COG0836@1|root,COG0662@2|Bacteria,COG0836@2|Bacteria,1MV39@1224|Proteobacteria,2VI4S@28216|Betaproteobacteria,1K0NF@119060|Burkholderiaceae 28216|Betaproteobacteria M Belongs to the mannose-6-phosphate isomerase type 2 family algA - 2.7.7.13,5.3.1.8 ko:K00971,ko:K16011 ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025 M00114,M00361,M00362 R00885,R01819 RC00002,RC00376 ko00000,ko00001,ko00002,ko01000 - - - MannoseP_isomer,NTP_transferase k59_500448_1 926569.ANT_00050 4.68e-85 265.0 COG1249@1|root,COG1249@2|Bacteria,2G5MR@200795|Chloroflexi 200795|Chloroflexi C Pyridine nucleotide-disulphide oxidoreductase dimerisation region lpd - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim k59_415905_1 880073.Calab_2464 1.85e-07 52.4 COG1729@1|root,COG1729@2|Bacteria 2|Bacteria S protein trimerization - - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Beta-lactamase,DUF3471,TPR_11,TPR_16,TPR_2,TPR_6,TPR_8 k59_415905_2 1340493.JNIF01000003_gene1717 8.11e-31 114.0 COG1259@1|root,COG1259@2|Bacteria,3Y4QD@57723|Acidobacteria 57723|Acidobacteria S Bifunctional nuclease - - - ko:K08999 - - - - ko00000 - - - DNase-RNase k59_201921_1 864069.MicloDRAFT_00069260 1.85e-75 236.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,1JSA1@119045|Methylobacteriaceae 28211|Alphaproteobacteria L transposase IS116 IS110 IS902 family - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_671647_2 395965.Msil_0834 7.06e-12 65.1 COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,2TRFZ@28211|Alphaproteobacteria,3NAHN@45404|Beijerinckiaceae 28211|Alphaproteobacteria T Transcriptional regulatory protein, C terminal phoB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K07657 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_802844_1 324602.Caur_3745 1.05e-56 192.0 COG3385@1|root,COG3385@2|Bacteria 2|Bacteria L transposase activity - - - - - - - - - - - - DDE_5 k59_880246_1 1458275.AZ34_02750 3.52e-102 310.0 COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,2WEXA@28216|Betaproteobacteria,4A9KB@80864|Comamonadaceae 28216|Betaproteobacteria P PFAM Sulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase k59_671667_1 639030.JHVA01000001_gene3031 2.26e-45 167.0 COG0577@1|root,COG0577@2|Bacteria,3Y71Z@57723|Acidobacteria,2JMB6@204432|Acidobacteriia 204432|Acidobacteriia V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_969265_1 78245.Xaut_5061 1.44e-58 194.0 COG3547@1|root,COG3547@2|Bacteria,1Q4TE@1224|Proteobacteria,2TT7C@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_33793_2 1144664.F973_01191 6.85e-24 96.3 COG1949@1|root,COG1949@2|Bacteria,1R9WX@1224|Proteobacteria,1S217@1236|Gammaproteobacteria,3NIIC@468|Moraxellaceae 1236|Gammaproteobacteria A 3'-to-5' exoribonuclease specific for small oligoribonucleotides orn GO:0000175,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004532,GO:0004536,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008296,GO:0008297,GO:0008310,GO:0008408,GO:0008946,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0016896,GO:0019439,GO:0034611,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140097,GO:0140098,GO:1901360,GO:1901361,GO:1901575 - ko:K13288 ko03008,map03008 - - - ko00000,ko00001,ko01000,ko03009,ko03019 - - - RNase_T k59_457978_1 530564.Psta_3779 1.91e-56 190.0 COG1914@1|root,COG1914@2|Bacteria,2IWTS@203682|Planctomycetes 203682|Planctomycetes P COG1914 Mn2 and Fe2 transporters of the NRAMP family - - - - - - - - - - - - Nramp k59_1267939_1 290512.Paes_0629 5.09e-84 261.0 COG3344@1|root,COG3344@2|Bacteria 2|Bacteria L reverse transcriptase - - - - - - - - - - - - GIIM,RVT_1 k59_376719_2 439235.Dalk_3998 3.35e-46 170.0 COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,42MRR@68525|delta/epsilon subdivisions,2WIQ7@28221|Deltaproteobacteria,2MIGW@213118|Desulfobacterales 28221|Deltaproteobacteria L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_33864_2 565045.NOR51B_1115 4.31e-43 143.0 COG2329@1|root,COG2329@2|Bacteria,1RJMH@1224|Proteobacteria,1SAYM@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Antibiotic biosynthesis monooxygenase - - - - - - - - - - - - ABM k59_880314_1 1175306.GWL_27450 1.8e-94 292.0 COG0129@1|root,COG0129@2|Bacteria,1MV4I@1224|Proteobacteria,2VKKY@28216|Betaproteobacteria,476HJ@75682|Oxalobacteraceae 28216|Betaproteobacteria EG Belongs to the IlvD Edd family - - 4.2.1.25 ko:K13875 ko00053,ko01100,map00053,map01100 - R02522 RC00543 ko00000,ko00001,ko01000 - - - ILVD_EDD k59_880314_2 1121106.JQKB01000032_gene4453 2.81e-73 226.0 COG1028@1|root,COG1028@2|Bacteria,1MU2T@1224|Proteobacteria,2TSDG@28211|Alphaproteobacteria,2JQMS@204441|Rhodospirillales 204441|Rhodospirillales IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short_C2 k59_756253_1 748247.AZKH_p0420 8.33e-51 168.0 28NKC@1|root,2ZBM7@2|Bacteria,1MWMY@1224|Proteobacteria,2VQ6Y@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_1103813_1 1131814.JAFO01000001_gene3628 2.26e-92 286.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_756256_1 864073.HFRIS_013459 5.35e-25 108.0 COG2202@1|root,COG2204@1|root,COG4585@1|root,COG2202@2|Bacteria,COG2204@2|Bacteria,COG4585@2|Bacteria,1MWPN@1224|Proteobacteria,2VJV5@28216|Betaproteobacteria 28216|Betaproteobacteria T Histidine kinase - - 2.7.13.3 ko:K07675 ko02020,map02020 M00473 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - CHASE,HATPase_c,HisKA_3,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_298386_1 640081.Dsui_0657 8.95e-53 187.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VJBX@28216|Betaproteobacteria,2KU9U@206389|Rhodocyclales 206389|Rhodocyclales NT Methyl-accepting chemotaxis protein pilJ - - ko:K02660 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001,ko02035,ko02044 - - - MCPsignal,PilJ k59_213143_2 857087.Metme_4132 5.13e-21 91.3 COG4254@1|root,COG4254@2|Bacteria,1N739@1224|Proteobacteria,1SE8D@1236|Gammaproteobacteria,1XFNJ@135618|Methylococcales 135618|Methylococcales S FecR protein - - - - - - - - - - - - FecR k59_170524_1 926550.CLDAP_24620 1.26e-10 63.2 COG1968@1|root,COG1968@2|Bacteria,2G6F7@200795|Chloroflexi 200795|Chloroflexi V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin uppP - 3.6.1.27 ko:K06153 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - BacA k59_42659_1 1121438.JNJA01000005_gene966 3.76e-08 53.9 COG0090@1|root,COG0090@2|Bacteria,1MVTD@1224|Proteobacteria,42MBV@68525|delta/epsilon subdivisions,2WIRE@28221|Deltaproteobacteria,2M8B7@213115|Desulfovibrionales 28221|Deltaproteobacteria J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity rplB GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02886 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L2,Ribosomal_L2_C k59_42659_2 1238182.C882_0612 9.56e-59 181.0 COG0185@1|root,COG0185@2|Bacteria,1RGYX@1224|Proteobacteria,2U95S@28211|Alphaproteobacteria,2JSNF@204441|Rhodospirillales 204441|Rhodospirillales J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA rpsS - - ko:K02965 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S19 k59_42659_3 1054213.HMPREF9946_00473 7.51e-26 99.4 COG0091@1|root,COG0091@2|Bacteria,1RH0W@1224|Proteobacteria,2U96X@28211|Alphaproteobacteria,2JSMQ@204441|Rhodospirillales 204441|Rhodospirillales J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome rplV - - ko:K02890 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L22 k59_298402_1 349163.Acry_0919 1.79e-113 348.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,2TR4E@28211|Alphaproteobacteria,2JQC9@204441|Rhodospirillales 204441|Rhodospirillales O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_341032_1 258594.RPA1469 1.73e-39 147.0 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2TU3V@28211|Alphaproteobacteria,3JRDY@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria J Amidase MA20_22685 - 3.5.1.84,6.3.5.6,6.3.5.7 ko:K02433,ko:K19837 ko00791,ko00970,ko01100,ko01120,map00791,map00970,map01100,map01120 - R03905,R04212,R05563 RC00010,RC01287 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_767268_2 794846.AJQU01000195_gene4794 6.57e-59 197.0 COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,2TS6X@28211|Alphaproteobacteria,4B8QI@82115|Rhizobiaceae 28211|Alphaproteobacteria S Putative transposase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_1193529_1 748247.AZKH_0279 9.88e-74 234.0 COG2159@1|root,COG2159@2|Bacteria,1R7E1@1224|Proteobacteria,2VPY4@28216|Betaproteobacteria,2KVED@206389|Rhodocyclales 206389|Rhodocyclales S Amidohydrolase uxuA - 4.2.1.8 ko:K01686 ko00040,ko01100,map00040,map01100 M00061 R05606 RC00543 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_2 k59_101_1 159450.NH14_28775 3.96e-30 117.0 COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,2VH54@28216|Betaproteobacteria,1K0PE@119060|Burkholderiaceae 28216|Betaproteobacteria M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain glmU - 2.3.1.157,2.7.7.23 ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,Hexapep_2,NTP_transf_3 k59_101_2 1265502.KB905930_gene1414 7.22e-89 269.0 COG1285@1|root,COG1285@2|Bacteria,1MURJ@1224|Proteobacteria,2WA1J@28216|Betaproteobacteria,4AFHN@80864|Comamonadaceae 28216|Betaproteobacteria S MgtC family - - - ko:K07507 - - - - ko00000,ko02000 9.B.20 - - MgtC k59_137_1 1110502.TMO_0697 7.36e-75 235.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TR15@28211|Alphaproteobacteria,2JV29@204441|Rhodospirillales 204441|Rhodospirillales I Acyl-CoA dehydrogenase, C-terminal domain - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_682103_2 1163617.SCD_n00008 1.53e-46 162.0 COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,2VIZJ@28216|Betaproteobacteria 28216|Betaproteobacteria S PFAM Peptidoglycan-binding LysM - - - - - - - - - - - - LysM k59_426379_1 270374.MELB17_10988 8.78e-108 313.0 COG0500@1|root,COG2226@2|Bacteria,1QU8Z@1224|Proteobacteria,1RS1E@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_23,Methyltransf_25 k59_1065763_1 395495.Lcho_1541 2.74e-69 230.0 COG0484@1|root,COG0484@2|Bacteria,1MXM9@1224|Proteobacteria,2VPQ6@28216|Betaproteobacteria 28216|Betaproteobacteria C heat shock protein binding - - - - - - - - - - - - Cytochrom_CIII k59_809995_1 114615.BRADO0330 3.61e-66 213.0 COG2801@1|root,COG3415@1|root,COG2801@2|Bacteria,COG3415@2|Bacteria,1N207@1224|Proteobacteria,2UEQQ@28211|Alphaproteobacteria,3JWDD@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - ko:K07497 - - - - ko00000 - - - HTH_28,HTH_32,LZ_Tnp_IS481,rve,rve_3 k59_383766_1 232721.Ajs_1825 7.12e-64 207.0 COG1485@1|root,COG1485@2|Bacteria,1MUUW@1224|Proteobacteria,2VHQX@28216|Betaproteobacteria,4AAAE@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM AFG1-family ATPase yhcM - - ko:K06916 - - - - ko00000,ko03036 - - - AFG1_ATPase k59_469027_1 1123392.AQWL01000005_gene3137 2.1e-93 303.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VI3F@28216|Betaproteobacteria,1KSFJ@119069|Hydrogenophilales 119069|Hydrogenophilales V AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran k59_426434_1 1123253.AUBD01000002_gene1227 4.58e-08 54.3 COG0408@1|root,COG0408@2|Bacteria,1MWMF@1224|Proteobacteria,1RMM8@1236|Gammaproteobacteria,1X3RT@135614|Xanthomonadales 135614|Xanthomonadales H Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX hemF GO:0003674,GO:0005488,GO:0005515,GO:0042802,GO:0042803,GO:0046983 1.3.3.3 ko:K00228 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03220 RC00884 ko00000,ko00001,ko00002,ko01000 - - - Coprogen_oxidas k59_426434_2 1123354.AUDR01000013_gene824 4.07e-151 438.0 COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,2VH9J@28216|Betaproteobacteria,1KS4T@119069|Hydrogenophilales 119069|Hydrogenophilales F Phosphoribosylglycinamide synthetase, C domain - - 6.3.4.13 ko:K01945 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144 RC00090,RC00166 ko00000,ko00001,ko00002,ko01000 - - - GARS_A,GARS_C,GARS_N k59_298593_1 323261.Noc_1083 2.91e-55 191.0 COG1305@1|root,COG1305@2|Bacteria,1MVV3@1224|Proteobacteria,1RRIA@1236|Gammaproteobacteria,1X0CC@135613|Chromatiales 135613|Chromatiales E 7 transmembrane helices usually fused to an inactive transglutaminase - - - - - - - - - - - - 7TM_transglut,Transglut_i_TM k59_1065840_1 983917.RGE_02200 8.22e-13 68.6 COG1975@1|root,COG1975@2|Bacteria,1MXKU@1224|Proteobacteria,2VHIK@28216|Betaproteobacteria,1KIZ4@119065|unclassified Burkholderiales 28216|Betaproteobacteria O XdhC Rossmann domain - - - ko:K07402 - - - - ko00000 - - - XdhC_C,XdhC_CoxI k59_1065840_2 1123393.KB891332_gene2832 2.78e-31 117.0 COG2068@1|root,COG2068@2|Bacteria,1MW0X@1224|Proteobacteria,2VSIN@28216|Betaproteobacteria,1KRTP@119069|Hydrogenophilales 119069|Hydrogenophilales S MobA-like NTP transferase domain - - - - - - - - - - - - NTP_transf_3 k59_298617_2 414684.RC1_2416 4.24e-15 76.6 COG0500@1|root,COG2226@2|Bacteria,1NDFZ@1224|Proteobacteria,2TVI5@28211|Alphaproteobacteria,2JRD6@204441|Rhodospirillales 204441|Rhodospirillales Q ubiE/COQ5 methyltransferase family - - - - - - - - - - - - Methyltransf_25 k59_682214_1 1121004.ATVC01000004_gene1491 1.31e-21 97.8 2A4J7@1|root,30T5U@2|Bacteria,1RGAU@1224|Proteobacteria,2VU2M@28216|Betaproteobacteria,2KR8I@206351|Neisseriales 206351|Neisseriales S Protein of unknown function (DUF3426) - - - - - - - - - - - - DUF3426,zinc_ribbon_5 k59_682214_2 497321.C664_18272 2.35e-68 216.0 COG0524@1|root,COG0524@2|Bacteria,1PDQE@1224|Proteobacteria,2VHMF@28216|Betaproteobacteria,2KUNE@206389|Rhodocyclales 206389|Rhodocyclales G COG0524 Sugar kinases, ribokinase family pfkB - 2.7.1.20 ko:K00856 ko00230,ko01100,map00230,map01100 - R00185 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB k59_682230_1 1187851.A33M_2605 5.58e-35 129.0 COG4177@1|root,COG4177@2|Bacteria,1PSHZ@1224|Proteobacteria,2TVQQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Branched-chain amino acid transport system / permease component - - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_682230_2 1038862.KB893829_gene5029 8.94e-92 276.0 COG0411@1|root,COG0411@2|Bacteria,1R3YN@1224|Proteobacteria,2U2IG@28211|Alphaproteobacteria,3JXXI@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Branched-chain amino acid ATP-binding cassette transporter - - - - - - - - - - - - ABC_tran,BCA_ABC_TP_C k59_767478_1 1353531.AZNX01000006_gene5681 5.27e-12 72.0 COG2202@1|root,COG3850@1|root,COG4191@1|root,COG2202@2|Bacteria,COG3850@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,4B9N5@82115|Rhizobiaceae 28211|Alphaproteobacteria T Histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS_3,PAS_4,PAS_8,dCache_1 k59_1151130_1 580332.Slit_1711 3.38e-130 397.0 COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,2VKSY@28216|Betaproteobacteria,44WAX@713636|Nitrosomonadales 28216|Betaproteobacteria C Molybdopterin oxidoreductase Fe4S4 domain - - 1.8.5.6 ko:K21307 ko00920,ko01100,ko01120,map00920,map01100,map01120 - R11487 RC00168 ko00000,ko00001,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_170775_1 1232683.ADIMK_0084 2.85e-51 181.0 COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,464A6@72275|Alteromonadaceae 1236|Gammaproteobacteria P COG0471 Di- and tricarboxylate transporters - - - - - - - - - - - - CitMHS,TrkA_C k59_980633_1 1123518.ARWI01000001_gene1639 4.49e-51 184.0 COG2132@1|root,COG2132@2|Bacteria,1PM6Q@1224|Proteobacteria,1RRZJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Parallel beta-helix repeats - - - - - - - - - - - - Cu-oxidase_3 k59_1236382_2 85643.Tmz1t_1784 2.51e-44 149.0 COG0802@1|root,COG0802@2|Bacteria,1RGYU@1224|Proteobacteria,2VSJY@28216|Betaproteobacteria,2KWJA@206389|Rhodocyclales 206389|Rhodocyclales S Threonylcarbamoyl adenosine biosynthesis protein TsaE - - - ko:K06925 - - - - ko00000,ko03016 - - - TsaE k59_1065942_1 305700.B447_05203 3.98e-85 268.0 COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,2VH2W@28216|Betaproteobacteria,2KUXJ@206389|Rhodocyclales 206389|Rhodocyclales T GTP-binding protein TypA typA - - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 k59_1151154_1 1123392.AQWL01000009_gene1047 5.78e-61 195.0 COG0705@1|root,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,2VQB1@28216|Betaproteobacteria,1KS9W@119069|Hydrogenophilales 119069|Hydrogenophilales S Rhomboid family - - - - - - - - - - - - Rhomboid k59_895390_1 1458275.AZ34_08905 3.87e-86 266.0 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,2VI29@28216|Betaproteobacteria,4AIFH@80864|Comamonadaceae 28216|Betaproteobacteria P Divalent cation transporter mgtE - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_724951_1 261292.Nit79A3_1044 2.57e-59 189.0 COG0107@1|root,COG0107@2|Bacteria,1MUS0@1224|Proteobacteria,2VHY0@28216|Betaproteobacteria,3724H@32003|Nitrosomonadales 28216|Betaproteobacteria E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit hisF GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 - ko:K02500 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth k59_724951_2 637390.AFOH01000106_gene93 5.49e-20 86.3 COG0139@1|root,COG0140@1|root,COG0139@2|Bacteria,COG0140@2|Bacteria,1MW67@1224|Proteobacteria,1RMV4@1236|Gammaproteobacteria,2NC07@225057|Acidithiobacillales 225057|Acidithiobacillales E Histidine biosynthesis bifunctional protein hisIE hisI - 3.5.4.19,3.6.1.31 ko:K11755 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04035,R04037 RC00002,RC01055 ko00000,ko00001,ko00002,ko01000 - - - PRA-CH,PRA-PH k59_511835_1 318424.EU78_06830 5.79e-13 73.9 COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,2GJRI@201174|Actinobacteria,2364D@1762|Mycobacteriaceae 201174|Actinobacteria T PFAM Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - AAA_16,Guanylate_cyc k59_810173_1 1538295.JY96_17045 2.13e-05 45.4 COG0705@1|root,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,2VQB1@28216|Betaproteobacteria,1KKR5@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Eukaryotic integral membrane protein (DUF1751) - - - - - - - - - - - - Rhomboid k59_810173_2 713586.KB900536_gene152 7.19e-33 127.0 COG4913@1|root,COG4913@2|Bacteria,1QUDU@1224|Proteobacteria,1T1V8@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF3300) yacH - - - - - - - - - - - DUF3300 k59_1236486_1 525378.HMPREF0793_2514 2.59e-36 134.0 COG0192@1|root,COG0192@2|Bacteria,1TPCV@1239|Firmicutes,4HB33@91061|Bacilli,4GXQB@90964|Staphylococcaceae 91061|Bacilli H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme metK GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N k59_1193874_1 522306.CAP2UW1_1683 1.33e-79 256.0 COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,2VH9I@28216|Betaproteobacteria,1KQJR@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria P Transport of potassium into the cell kup - - ko:K03549 - - - - ko00000,ko02000 2.A.72 - - K_trans k59_128265_1 745277.GRAQ_00899 3.31e-36 139.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,3FF2G@34037|Rahnella 1236|Gammaproteobacteria NT Homologues of the ligand binding domain of Tar tap GO:0003674,GO:0004888,GO:0005575,GO:0005623,GO:0005886,GO:0006935,GO:0007154,GO:0007165,GO:0008150,GO:0009605,GO:0009987,GO:0016020,GO:0023052,GO:0038023,GO:0040011,GO:0042221,GO:0042330,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007,GO:0071944 - ko:K03406,ko:K05874,ko:K05875,ko:K05876,ko:K05877 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,TarH k59_554521_1 1122134.KB893650_gene515 6.82e-25 100.0 COG1246@1|root,COG1246@2|Bacteria,1NBIV@1224|Proteobacteria,1SD3W@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Acetyltransferase (GNAT) family - - 2.3.1.1 ko:K00619 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - Acetyltransf_1,Acetyltransf_10 k59_554521_2 1120999.JONM01000021_gene131 7.27e-17 73.9 COG5470@1|root,COG5470@2|Bacteria,1N7JA@1224|Proteobacteria,2VUU6@28216|Betaproteobacteria 28216|Betaproteobacteria S Domain of unknown function (DUF1330) - - - - - - - - - - - - DUF1330 k59_1279083_1 379066.GAU_0070 9.12e-55 193.0 COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,1ZUF3@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase k59_43063_2 1479235.KK366039_gene1426 1.1e-26 112.0 28WQX@1|root,2ZIQM@2|Bacteria 2|Bacteria S HlyD family secretion protein - - 2.4.1.33 ko:K19291 ko00051,ko02025,map00051,map02025 - R08692 RC00005 ko00000,ko00001,ko01000 - - - HlyD_3,PilZ k59_938150_1 497321.C664_09090 1.38e-107 343.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,2VHF3@28216|Betaproteobacteria,2KV0Q@206389|Rhodocyclales 206389|Rhodocyclales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_852874_1 861299.J421_0899 1.28e-30 124.0 COG5492@1|root,COG5492@2|Bacteria,1ZSW8@142182|Gemmatimonadetes 2|Bacteria N domain, Protein - - 3.2.1.4,3.4.17.14 ko:K01179,ko:K07260,ko:K13735 ko00500,ko00550,ko01100,ko01502,ko02020,ko05100,map00500,map00550,map01100,map01502,map02020,map05100 M00651 R06200,R11307,R11308 - ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504 - GH5,GH9 - Big_1,Big_2,Glug,IAT_beta,Invasin_D3,LysM,Mfa_like_1,SLH k59_1023513_1 1244869.H261_11334 1.72e-92 286.0 COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,2TRSU@28211|Alphaproteobacteria,2JQAZ@204441|Rhodospirillales 204441|Rhodospirillales J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX - 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - - tRNA-synt_1c k59_128290_1 1469613.JT55_05210 8.58e-38 143.0 COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,2TS87@28211|Alphaproteobacteria,3FCJX@34008|Rhodovulum 28211|Alphaproteobacteria S Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis - - - ko:K03688 - - - - ko00000 - - - ABC1 k59_852901_1 1122137.AQXF01000007_gene3574 4.33e-69 223.0 COG1249@1|root,COG1249@2|Bacteria,1MU2Z@1224|Proteobacteria,2TQS7@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family gor GO:0000166,GO:0000302,GO:0000305,GO:0003674,GO:0005488,GO:0005507,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0010035,GO:0017076,GO:0019725,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0045454,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0065007,GO:0065008,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901700 1.8.1.7 ko:K00383 ko00480,ko04918,map00480,map04918 - R00094,R00115 RC00011 ko00000,ko00001,ko01000 - - - Pyr_redox_2,Pyr_redox_dim k59_128351_1 34506.g6040 2.57e-70 238.0 COG0642@1|root,COG1025@1|root,COG5641@1|root,KOG0519@2759|Eukaryota,KOG0959@2759|Eukaryota,KOG1601@2759|Eukaryota,3AGK5@33154|Opisthokonta,3BXQF@33208|Metazoa,3DDEZ@33213|Bilateria 33208|Metazoa K Sigma-54 interaction domain - - - - - - - - - - - - Response_reg,Sigma54_activat k59_980848_1 243233.MCA1757 5.33e-91 297.0 COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU43@1224|Proteobacteria,1RMRH@1236|Gammaproteobacteria,1XEVZ@135618|Methylococcales 135618|Methylococcales C Protein of unknown function (DUF3683) - - - - - - - - - - - - CCG,DUF3400,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_8 k59_1066193_1 1307759.JOMJ01000003_gene2119 8.12e-23 102.0 COG3387@1|root,COG3387@2|Bacteria,1MV08@1224|Proteobacteria,42QCJ@68525|delta/epsilon subdivisions,2WKE7@28221|Deltaproteobacteria,2M98Q@213115|Desulfovibrionales 28221|Deltaproteobacteria G PFAM Glycoside hydrolase 15-related - - - - - - - - - - - - DUF547,Glyco_hydro_15 k59_1066193_2 393595.ABO_0202 3.48e-09 57.0 COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,1RMD2@1236|Gammaproteobacteria,1XHHA@135619|Oceanospirillales 135619|Oceanospirillales E Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate alkJ2 - 1.1.99.1 ko:K00108 ko00260,ko01100,map00260,map01100 M00555 R01025 RC00087 ko00000,ko00001,ko00002,ko01000 - - - GMC_oxred_C,GMC_oxred_N k59_43147_1 1049564.TevJSym_al00210 2.31e-85 280.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1146@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria,1J7JF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin nifJ - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C k59_511981_1 338969.Rfer_0857 3.22e-84 261.0 COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,2VKHP@28216|Betaproteobacteria,4ADTA@80864|Comamonadaceae 28216|Betaproteobacteria V PFAM ABC-2 type transporter - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 k59_554611_1 991.IW20_11255 1.23e-31 129.0 COG0308@1|root,COG0308@2|Bacteria,4NGTZ@976|Bacteroidetes,1HY7M@117743|Flavobacteriia,2NTII@237|Flavobacterium 976|Bacteroidetes E Peptidase family M1 domain pepN - 3.4.11.2 ko:K01256 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - ERAP1_C,Peptidase_M1 k59_637_1 633131.TR2A62_1845 6.25e-32 117.0 COG5319@1|root,COG5319@2|Bacteria,1MZN2@1224|Proteobacteria,2UBTA@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein conserved in bacteria MA20_39715 - - - - - - - - - - - DUF1178 k59_1321876_1 1380355.JNIJ01000047_gene228 9.15e-96 298.0 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,3JR8W@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Adenylate cyclase - - - - - - - - - - - - Guanylate_cyc k59_767757_1 1121035.AUCH01000019_gene2850 1.08e-32 124.0 COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,2VHBR@28216|Betaproteobacteria,2KV2X@206389|Rhodocyclales 206389|Rhodocyclales F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP purA - 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 - - - Adenylsucc_synt k59_767757_2 987059.RBXJA2T_17981 5.36e-06 48.9 COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,2VHBJ@28216|Betaproteobacteria,1KJ8G@119065|unclassified Burkholderiales 28216|Betaproteobacteria J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs rnr - - ko:K12573 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03016,ko03019 - - - OB_RNB,RNB,S1 k59_384120_1 518766.Rmar_0188 2.38e-83 257.0 COG2897@1|root,COG2897@2|Bacteria,4NF85@976|Bacteroidetes 976|Bacteroidetes P sulfurtransferase sseA - 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese k59_85817_1 1122137.AQXF01000001_gene2709 5.25e-91 283.0 COG4962@1|root,COG4962@2|Bacteria,1R7EN@1224|Proteobacteria,2TRNT@28211|Alphaproteobacteria 28211|Alphaproteobacteria U pilus assembly protein ATPase CpaF - - - ko:K02283 - - - - ko00000,ko02035,ko02044 - - - T2SSE k59_128414_1 29581.BW37_02699 1.56e-49 174.0 COG0642@1|root,COG2205@2|Bacteria,1N58A@1224|Proteobacteria,2VHVP@28216|Betaproteobacteria,476IJ@75682|Oxalobacteraceae 28216|Betaproteobacteria T PFAM HAMP domain, Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, His Kinase A (phosphoacceptor) domain yfhK - 2.7.13.3 ko:K07711 ko02020,ko02024,map02020,map02024 M00502 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA k59_128448_1 314285.KT71_07974 4.25e-52 173.0 COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,1RM8G@1236|Gammaproteobacteria,1J8TU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Pterin binding enzyme folP GO:0003674,GO:0003824,GO:0004156,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042221,GO:0042364,GO:0042398,GO:0042493,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046655,GO:0046656,GO:0050896,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.15 ko:K00796 ko00790,ko01100,map00790,map01100 M00126,M00841 R03066,R03067 RC00121,RC00842 ko00000,ko00001,ko00002,ko01000 - - iECO103_1326.ECO103_3924,iPC815.YPO3501 Pterin_bind k59_128448_2 1469245.JFBG01000084_gene203 4.03e-33 125.0 COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,1RMR2@1236|Gammaproteobacteria,1WW1H@135613|Chromatiales 135613|Chromatiales G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate glmM - 5.4.2.10 ko:K03431 ko00520,ko01100,ko01130,map00520,map01100,map01130 - R02060 RC00408 ko00000,ko00001,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_256353_1 391625.PPSIR1_16130 8.49e-56 188.0 COG3039@1|root,COG3039@2|Bacteria,1R70H@1224|Proteobacteria,42Y58@68525|delta/epsilon subdivisions,2WTVD@28221|Deltaproteobacteria 28221|Deltaproteobacteria L Transposase domain (DUF772) - - - ko:K07487 - - - - ko00000 - - - DDE_Tnp_1,DUF772 k59_767834_1 180281.CPCC7001_2483 4.97e-49 168.0 COG0176@1|root,COG0176@2|Bacteria,1G292@1117|Cyanobacteria,22RUZ@167375|Cyanobium 1117|Cyanobacteria H Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway tal GO:0003674,GO:0003824,GO:0004801,GO:0016740,GO:0016744 2.2.1.2 ko:K00616 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01827 RC00439,RC00604 ko00000,ko00001,ko00002,ko01000 - - - EF-hand_5,TAL_FSA k59_767834_2 1158292.JPOE01000002_gene2298 1.42e-60 203.0 COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,2VM9R@28216|Betaproteobacteria,1KKEG@119065|unclassified Burkholderiales 28216|Betaproteobacteria C NADPH-dependent glutamate synthase beta korC - - - - - - - - - - - Fer4_20,Fer4_7,Pyr_redox_2,Pyr_redox_3 k59_1279266_2 396588.Tgr7_3063 1.82e-68 231.0 COG0045@1|root,COG0454@1|root,COG1042@1|root,COG0045@2|Bacteria,COG0456@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,1RPXX@1236|Gammaproteobacteria,1WWWU@135613|Chromatiales 135613|Chromatiales C CoA-binding domain protein - - - ko:K09181 - - - - ko00000 - - - ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig k59_899867_1 318161.Sden_3430 1.17e-22 97.4 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,2Q984@267890|Shewanellaceae 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_899867_2 1210884.HG799463_gene9368 0.0009 43.1 COG4805@1|root,COG4805@2|Bacteria,2IXQZ@203682|Planctomycetes 203682|Planctomycetes S Bacterial protein of unknown function (DUF885) - - - - - - - - - - - - DUF885 k59_1199399_1 1207063.P24_00485 1.78e-168 496.0 COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2TQY9@28211|Alphaproteobacteria,2JRIJ@204441|Rhodospirillales 204441|Rhodospirillales S Tripartite ATP-independent periplasmic transporter, DctM component - - - - - - - - - - - - DctM k59_133119_1 1123366.TH3_07025 2.98e-30 115.0 COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,2TR5J@28211|Alphaproteobacteria,2JQTM@204441|Rhodospirillales 204441|Rhodospirillales L exodeoxyribonuclease III xth - 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos k59_90591_1 666681.M301_0438 2.61e-42 149.0 COG5281@1|root,COG5281@2|Bacteria,1NZ1M@1224|Proteobacteria,2VS5T@28216|Betaproteobacteria 28216|Betaproteobacteria D sister chromatid segregation - - - - - - - - - - - - - k59_49442_1 1300345.LF41_2610 1.32e-43 166.0 COG2909@1|root,COG3629@1|root,COG2909@2|Bacteria,COG3629@2|Bacteria,1MVZZ@1224|Proteobacteria,1RN29@1236|Gammaproteobacteria,1X3EM@135614|Xanthomonadales 135614|Xanthomonadales K transcriptional regulator acoK - - ko:K03556 - - - - ko00000,ko03000 - - - AAA_16,AAA_25,GerE,TPR_12 k59_559483_1 1205680.CAKO01000010_gene3839 3.87e-52 174.0 COG0329@1|root,COG0329@2|Bacteria,1MXM5@1224|Proteobacteria,2TUAG@28211|Alphaproteobacteria,2JRY4@204441|Rhodospirillales 204441|Rhodospirillales EM Belongs to the DapA family - - 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - DHDPS k59_559483_2 1280952.HJA_03026 6.64e-08 53.9 COG1304@1|root,COG1304@2|Bacteria,1MUEZ@1224|Proteobacteria,2TQNW@28211|Alphaproteobacteria,43WFR@69657|Hyphomonadaceae 28211|Alphaproteobacteria C COG1304 L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases lldD1 GO:0002218,GO:0002253,GO:0002376,GO:0002682,GO:0002684,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0006950,GO:0006952,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009058,GO:0009605,GO:0009607,GO:0009617,GO:0009987,GO:0010204,GO:0016999,GO:0017000,GO:0017144,GO:0023052,GO:0031347,GO:0031349,GO:0042579,GO:0042742,GO:0042743,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044249,GO:0044424,GO:0044444,GO:0044464,GO:0045088,GO:0045089,GO:0048518,GO:0048583,GO:0048584,GO:0050665,GO:0050776,GO:0050778,GO:0050789,GO:0050794,GO:0050896,GO:0051186,GO:0051188,GO:0051704,GO:0051707,GO:0051716,GO:0065007,GO:0072593,GO:0080134,GO:0098542,GO:1903409 1.1.2.3 ko:K00101 ko00620,ko01100,map00620,map01100 - R00196 RC00044 ko00000,ko00001,ko01000 - - - FMN_dh k59_645174_1 305900.GV64_21950 5.2e-51 174.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,1XICI@135619|Oceanospirillales 135619|Oceanospirillales O Belongs to the peptidase S1C family - - 3.4.21.107 ko:K04691,ko:K04771,ko:K04772 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ,PDZ_2,Trypsin_2 k59_474791_1 1123255.JHYS01000005_gene640 3.08e-53 177.0 COG1651@1|root,COG1651@2|Bacteria,1RD39@1224|Proteobacteria,2VIHV@28216|Betaproteobacteria,4AASK@80864|Comamonadaceae 28216|Betaproteobacteria O Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process dsbC - 5.3.4.1 ko:K03981 - - - - ko00000,ko01000,ko02044,ko03110 3.A.7.11.1 - - DsbC_N,Thioredoxin_2 k59_1199453_1 323848.Nmul_A0388 6.41e-95 298.0 COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,2VHNX@28216|Betaproteobacteria,372XV@32003|Nitrosomonadales 28216|Betaproteobacteria H Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate tkt - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_133166_1 1122137.AQXF01000004_gene1641 2.18e-49 164.0 COG1024@1|root,COG1024@2|Bacteria,1MXHV@1224|Proteobacteria,2TTEG@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Belongs to the enoyl-CoA hydratase isomerase family MA20_38145 - - - - - - - - - - - ECH_1 k59_133166_2 262316.MAP_3879c 5.57e-45 152.0 COG1028@1|root,COG1028@2|Bacteria,2GJW1@201174|Actinobacteria,232H3@1762|Mycobacteriaceae 201174|Actinobacteria IQ Dehydrogenase - - 1.1.1.100 ko:K00059,ko:K07535 ko00061,ko00333,ko00362,ko00780,ko01040,ko01100,ko01120,ko01130,ko01212,ko01220,map00061,map00333,map00362,map00780,map01040,map01100,map01120,map01130,map01212,map01220 M00083,M00540,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R05582,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117,RC00154 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_176506_1 1267535.KB906767_gene1134 2.73e-23 97.8 COG2873@1|root,COG2873@2|Bacteria,3Y2JU@57723|Acidobacteria,2JMB4@204432|Acidobacteriia 204432|Acidobacteriia E DegT/DnrJ/EryC1/StrS aminotransferase family - - 2.5.1.49 ko:K01740 ko00270,ko01100,map00270,map01100 - R01287,R04859 RC00020,RC02821,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP k59_730555_1 1304878.AUGD01000001_gene607 1.51e-65 217.0 COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,3JR8W@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Adenylate cyclase - - - - - - - - - - - - Guanylate_cyc,TPR_16,TPR_2,TPR_8,Trans_reg_C k59_1328151_1 314225.ELI_14900 8.9e-121 351.0 COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,2K2F6@204457|Sphingomonadales 204457|Sphingomonadales L COG2801 Transposase and inactivated derivatives - - - - - - - - - - - - HTH_21,rve,rve_3 k59_1242147_1 1254432.SCE1572_50615 6.3e-67 213.0 COG4106@1|root,COG4106@2|Bacteria,1Q2Y3@1224|Proteobacteria,43A9Z@68525|delta/epsilon subdivisions,2X37W@28221|Deltaproteobacteria,2YV2G@29|Myxococcales 28221|Deltaproteobacteria S Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate tam - 2.1.1.144 ko:K00598 - - - - ko00000,ko01000 - - - Methyltransf_23,Methyltransf_25 k59_1030615_1 622312.ROSEINA2194_03286 5.85e-09 62.8 COG0421@1|root,COG0421@2|Bacteria,1TPG5@1239|Firmicutes,24827@186801|Clostridia 186801|Clostridia H Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine speE - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synt_N,Spermine_synth k59_305909_1 648757.Rvan_0598 1.14e-28 105.0 COG1553@1|root,COG1553@2|Bacteria,1N021@1224|Proteobacteria,2UA3H@28211|Alphaproteobacteria 28211|Alphaproteobacteria P DsrE/DsrF-like family - - - ko:K07235 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - DrsE k59_305909_2 580332.Slit_1683 3.04e-54 172.0 COG2923@1|root,COG2923@2|Bacteria,1N8RV@1224|Proteobacteria,2VSQ5@28216|Betaproteobacteria,44WHC@713636|Nitrosomonadales 28216|Betaproteobacteria P DsrE/DsrF-like family - - - ko:K07236 ko04122,map04122 - - - ko00000,ko00001,ko03016 - - - DrsE k59_305909_3 765911.Thivi_0548 7.26e-05 42.4 COG2168@1|root,COG2168@2|Bacteria,1NGF3@1224|Proteobacteria,1SGPI@1236|Gammaproteobacteria,1WYI4@135613|Chromatiales 135613|Chromatiales P sulfur relay protein TusB DsrH - - - ko:K07237 ko04122,map04122 - - - ko00000,ko00001,ko03016 - - - DsrH k59_774063_1 1131813.AQVT01000001_gene4181 9.8e-53 176.0 COG1125@1|root,COG1125@2|Bacteria,1QTUC@1224|Proteobacteria,2TTMA@28211|Alphaproteobacteria,1JR68@119045|Methylobacteriaceae 28211|Alphaproteobacteria E PFAM ABC transporter - - - ko:K05847 ko02010,map02010 M00209 - - ko00000,ko00001,ko00002,ko02000 3.A.1.12 - - ABC_tran k59_474864_1 1049564.TevJSym_aq00810 7.7e-68 233.0 COG0674@1|root,COG1013@1|root,COG1144@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1144@2|Bacteria,COG1146@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria 2|Bacteria C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin forE - 1.2.7.1 ko:K00171,ko:K00172,ko:K02573,ko:K03737,ko:K13795,ko:K18930 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034,R10866 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - CCG,Fer4,Fer4_4,Fer4_6,Fer4_9,Nitroreductase,PFOR_II,POR,POR_N,TPP_enzyme_C k59_1199517_1 296591.Bpro_1709 5.35e-82 251.0 COG2267@1|root,COG2267@2|Bacteria,1MV7P@1224|Proteobacteria,2VPTY@28216|Betaproteobacteria,4AGS7@80864|Comamonadaceae 28216|Betaproteobacteria I Serine aminopeptidase, S33 - - - - - - - - - - - - Hydrolase_4 k59_261231_1 94624.Bpet1727 5.45e-24 101.0 COG4553@1|root,COG4553@2|Bacteria,1MVUH@1224|Proteobacteria,2VIP8@28216|Betaproteobacteria,3T2UP@506|Alcaligenaceae 28216|Betaproteobacteria I PHB de-polymerase C-terminus phaZ - 3.1.1.75 ko:K05973 ko00650,map00650 - R05118 - ko00000,ko00001,ko01000 - - - PHB_depo_C k59_7671_1 1123376.AUIU01000011_gene878 1.39e-50 171.0 COG0180@1|root,COG0180@2|Bacteria,3J0A0@40117|Nitrospirae 40117|Nitrospirae J tRNA synthetases class I (W and Y) trpS - 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1b k59_730618_1 883126.HMPREF9710_04832 9.82e-68 223.0 COG1538@1|root,COG1538@2|Bacteria,1MWB0@1224|Proteobacteria,2VIIW@28216|Betaproteobacteria,473BE@75682|Oxalobacteraceae 28216|Betaproteobacteria MU Outer membrane efflux protein copB - - - - - - - - - - - OEP k59_7686_1 118161.KB235922_gene5825 5.08e-65 210.0 COG5433@1|root,COG5433@2|Bacteria,1G0VN@1117|Cyanobacteria,3VJBK@52604|Pleurocapsales 1117|Cyanobacteria L DDE_Tnp_1-associated - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_assoc k59_1199554_1 765911.Thivi_1408 7.45e-86 272.0 COG0457@1|root,COG0457@2|Bacteria,1N01S@1224|Proteobacteria,1S0RI@1236|Gammaproteobacteria,1X05M@135613|Chromatiales 135613|Chromatiales S COG0457 FOG TPR repeat - - - - - - - - - - - - - k59_1199554_2 1547437.LL06_08810 1.34e-40 148.0 COG1593@1|root,COG1593@2|Bacteria,1N1HM@1224|Proteobacteria,2TR8B@28211|Alphaproteobacteria,43HPN@69277|Phyllobacteriaceae 28211|Alphaproteobacteria G Tripartite ATP-independent periplasmic transporter, DctM component - - - - - - - - - - - - DctM k59_774131_1 1317118.ATO8_14447 2.2e-22 92.0 COG0824@1|root,COG0824@2|Bacteria,1MZPN@1224|Proteobacteria,2UCYR@28211|Alphaproteobacteria,4KMTK@93682|Roseivivax 28211|Alphaproteobacteria S Thioesterase superfamily - - 3.1.2.23 ko:K01075 ko00130,ko00362,ko01100,ko01110,ko01120,map00130,map00362,map01100,map01110,map01120 - R01301 RC00004,RC00174 ko00000,ko00001,ko01000 - - - 4HBT,4HBT_2 k59_774131_2 342113.DM82_3912 5.95e-12 65.9 COG0654@1|root,COG0654@2|Bacteria,1MV8T@1224|Proteobacteria,2VIVU@28216|Betaproteobacteria,1K0KK@119060|Burkholderiaceae 28216|Betaproteobacteria CH 4-hydroxybenzoate 3-monooxygenase pobA - 1.14.13.2 ko:K00481 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 - R01298 RC00046 ko00000,ko00001,ko01000 - - - FAD_binding_3 k59_1242224_1 443152.MDG893_18904 1.13e-16 85.1 COG2206@1|root,COG2206@2|Bacteria,1MW7F@1224|Proteobacteria,1RPEZ@1236|Gammaproteobacteria,465ZX@72275|Alteromonadaceae 1236|Gammaproteobacteria T COG2206 HD-GYP domain - - - - - - - - - - - - DUF3391,HD,HD_5 k59_1242224_2 525904.Tter_1004 4.63e-20 92.4 COG0515@1|root,COG0515@2|Bacteria,2NPFQ@2323|unclassified Bacteria 2|Bacteria KLT Serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,PEGA,Pkinase k59_7718_1 485916.Dtox_3908 5.1e-10 63.5 COG5362@1|root,COG5410@1|root,COG5362@2|Bacteria,COG5410@2|Bacteria,1TSQB@1239|Firmicutes,24ACE@186801|Clostridia,262AU@186807|Peptococcaceae 186801|Clostridia S TIGRFAM Phage uncharacterised protein, C-terminal - - - - - - - - - - - - Terminase_6C k59_176622_1 1123487.KB892868_gene1244 2.27e-22 99.0 COG0631@1|root,COG0631@2|Bacteria,1MVE7@1224|Proteobacteria,2VIAV@28216|Betaproteobacteria,2KUHY@206389|Rhodocyclales 206389|Rhodocyclales T COG0631 Serine threonine protein phosphatase - - 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C_2 k59_347866_1 314285.KT71_01925 1.35e-79 241.0 COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,1S5WI@1236|Gammaproteobacteria,1J998@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C SelR domain - - 1.8.4.12 ko:K07305 - - - - ko00000,ko01000 - - - SelR,TAT_signal k59_1113592_1 237609.PSAKL28_27540 7.42e-40 152.0 COG2132@1|root,COG2132@2|Bacteria,1N9H3@1224|Proteobacteria 1224|Proteobacteria Q Multicopper oxidase - - 1.16.3.3 ko:K22349 - - - - ko00000,ko01000 - - - - k59_1242298_2 1232410.KI421414_gene2846 2.04e-19 86.3 COG2121@1|root,COG2121@2|Bacteria,1MZID@1224|Proteobacteria,42UW6@68525|delta/epsilon subdivisions,2WQ4A@28221|Deltaproteobacteria,43T0K@69541|Desulfuromonadales 28221|Deltaproteobacteria S Domain of unknown function (DUF374) - - - ko:K09778 - - - - ko00000 - - - DUF374 k59_559689_1 640081.Dsui_1191 3.02e-102 321.0 COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,2VHY4@28216|Betaproteobacteria,2KUHK@206389|Rhodocyclales 206389|Rhodocyclales U Type 4 fimbrial biogenesis protein pilQ - - ko:K02666 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - AMIN,STN,Secretin,Secretin_N k59_943871_1 1304883.KI912532_gene2516 2.42e-06 48.1 COG3332@1|root,COG3332@2|Bacteria,1RDBS@1224|Proteobacteria,2VQK6@28216|Betaproteobacteria,2KW9M@206389|Rhodocyclales 206389|Rhodocyclales S Transport and Golgi organisation 2 - - - - - - - - - - - - TANGO2 k59_943871_2 331869.BAL199_15543 2.37e-64 207.0 COG2816@1|root,COG2816@2|Bacteria,1QGCX@1224|Proteobacteria,2TVMG@28211|Alphaproteobacteria,4BQFR@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria L NADH pyrophosphatase-like rudimentary NUDIX domain nudC - 3.6.1.22 ko:K03426 ko00760,ko01100,ko04146,map00760,map01100,map04146 - R00103,R03004,R11104 RC00002 ko00000,ko00001,ko01000 - - - NUDIX,NUDIX-like,zf-NADH-PPase k59_176708_1 1123487.KB892867_gene1046 3.84e-81 248.0 COG0329@1|root,COG0329@2|Bacteria,1MUCM@1224|Proteobacteria,2VIQ4@28216|Betaproteobacteria,2KUG2@206389|Rhodocyclales 206389|Rhodocyclales E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) dapA - 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - DHDPS k59_49786_1 948106.AWZT01000003_gene5828 1.36e-98 305.0 COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,2VIGG@28216|Betaproteobacteria,1K1UR@119060|Burkholderiaceae 28216|Betaproteobacteria D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA - - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc k59_1199703_1 1122169.AREN01000027_gene1531 2.74e-25 106.0 COG3239@1|root,COG3239@2|Bacteria,1MW29@1224|Proteobacteria,1RPHS@1236|Gammaproteobacteria,1JCWT@118969|Legionellales 118969|Legionellales I Fatty acid desaturase - - 1.14.15.3 ko:K00496 ko00071,ko00930,map00071,map00930 - R01347,R02281,R06945 RC00478 ko00000,ko00001,ko01000 - - - FA_desaturase k59_1199703_2 1502851.FG93_04250 1.59e-10 60.8 COG0129@1|root,COG0129@2|Bacteria,1MV4I@1224|Proteobacteria,2TQRW@28211|Alphaproteobacteria,3JR3Q@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria EG Dehydratase family MA20_39205 - 4.2.1.82 ko:K22186 ko00040,map00040 - R02429 RC00543 ko00000,ko00001,ko01000 - - - ILVD_EDD k59_688206_1 543728.Vapar_2799 5.87e-10 63.9 COG1716@1|root,COG2114@1|root,COG1716@2|Bacteria,COG2114@2|Bacteria,1NAJG@1224|Proteobacteria,2VJW8@28216|Betaproteobacteria,4AATS@80864|Comamonadaceae 28216|Betaproteobacteria T Adenylyl cyclase class-3 4 guanylyl cyclase - - - - - - - - - - - - FHA,Guanylate_cyc k59_604524_2 279714.FuraDRAFT_3207 3.06e-35 128.0 COG2116@1|root,COG2116@2|Bacteria,1MU0W@1224|Proteobacteria,2VKMF@28216|Betaproteobacteria,2KRVB@206351|Neisseriales 206351|Neisseriales P Formate/nitrite transporter fnt - - ko:K02598,ko:K21993 - - - - ko00000,ko02000 1.A.16.2,1.A.16.3 - - Form_Nir_trans k59_774320_1 1121405.dsmv_1085 1.02e-14 80.1 COG3225@1|root,COG3225@2|Bacteria,1MY63@1224|Proteobacteria,42N95@68525|delta/epsilon subdivisions,2WJ0N@28221|Deltaproteobacteria,2MJFD@213118|Desulfobacterales 28221|Deltaproteobacteria N ABC-type uncharacterized transport system - - - - - - - - - - - - ABC_transp_aux k59_1157103_1 204669.Acid345_1097 3.46e-78 249.0 COG0459@1|root,COG0459@2|Bacteria,3Y37I@57723|Acidobacteria,2JIV1@204432|Acidobacteriia 204432|Acidobacteriia O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL - - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_986594_1 640081.Dsui_1809 4.35e-95 293.0 COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,2VIE0@28216|Betaproteobacteria,2KUDK@206389|Rhodocyclales 206389|Rhodocyclales H DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity dnaX - 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNA_pol3_gamma3,DNA_pol3_tau_5 k59_1328456_1 582744.Msip34_0665 2.7e-15 74.3 COG1192@1|root,COG1192@2|Bacteria,1QBJX@1224|Proteobacteria,2VJNI@28216|Betaproteobacteria,2KMPQ@206350|Nitrosomonadales 206350|Nitrosomonadales D ATPase MipZ - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31,CbiA k59_1113700_1 1268622.AVS7_04524 1.26e-19 87.8 COG4948@1|root,COG4948@2|Bacteria,1MYZE@1224|Proteobacteria,2VMQJ@28216|Betaproteobacteria,4AEJ5@80864|Comamonadaceae 28216|Betaproteobacteria M Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - 4.2.1.156,4.2.1.42 ko:K20023 ko00053,map00053 - R05608 RC00543 ko00000,ko00001,ko01000 - - - MR_MLE_C,MR_MLE_N k59_1113700_2 257310.BB4884 1.64e-06 53.1 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VJJD@28216|Betaproteobacteria,3T2PV@506|Alcaligenaceae 28216|Betaproteobacteria C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_1157120_1 1144310.PMI07_002360 3.96e-07 57.8 2DPZ1@1|root,3340X@2|Bacteria,1R2EE@1224|Proteobacteria,2TZIB@28211|Alphaproteobacteria,4BP2Q@82115|Rhizobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_133417_1 402881.Plav_1796 5.18e-59 198.0 COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2U2SV@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 k59_49861_1 288000.BBta_4458 3.49e-97 293.0 COG0498@1|root,COG0498@2|Bacteria,1R7X1@1224|Proteobacteria,2TUR3@28211|Alphaproteobacteria,3JU0E@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Pyridoxal-phosphate dependent enzyme MA20_41710 - 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_604571_1 926569.ANT_19080 2.78e-71 228.0 COG0593@1|root,COG0593@2|Bacteria,2G5W8@200795|Chloroflexi 200795|Chloroflexi L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k59_517789_2 1462527.CCDM010000001_gene2551 4.09e-27 108.0 COG4948@1|root,COG4948@2|Bacteria,1TS0S@1239|Firmicutes,4HC1G@91061|Bacilli,23J0I@182709|Oceanobacillus 91061|Bacilli M Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - - - - - - - - - - MR_MLE_C,MR_MLE_N k59_730838_1 765912.Thimo_0053 8.63e-10 63.9 2C8JT@1|root,31A2G@2|Bacteria,1RKRE@1224|Proteobacteria,1SI91@1236|Gammaproteobacteria,1WYIM@135613|Chromatiales 135613|Chromatiales S general secretion pathway protein - - - - - - - - - - - - T2SSC k59_348090_1 1121022.ABENE_11015 9.46e-21 89.7 COG3547@1|root,COG3547@2|Bacteria,1Q4TE@1224|Proteobacteria,2TT7C@28211|Alphaproteobacteria,2KIIT@204458|Caulobacterales 204458|Caulobacterales L Transposase IS116/IS110/IS902 family - - - - - - - - - - - - Transposase_20 k59_53400_1 296591.Bpro_0611 8.1e-88 266.0 COG3121@1|root,COG3121@2|Bacteria,1R4RJ@1224|Proteobacteria,2VXCK@28216|Betaproteobacteria,4AFJT@80864|Comamonadaceae 28216|Betaproteobacteria M Pili and flagellar-assembly chaperone, PapD N-terminal domain papD - - ko:K07346 - - - - ko00000,ko02035,ko02044,ko03110 - - - PapD_N k59_946749_2 864051.BurJ1DRAFT_4923 7.74e-55 180.0 COG2050@1|root,COG2050@2|Bacteria,1N57X@1224|Proteobacteria,2VTJB@28216|Betaproteobacteria 28216|Betaproteobacteria Q Thioesterase-like superfamily - - - - - - - - - - - - 4HBT_3 k59_860425_1 1002340.AFCF01000054_gene1865 1.4e-43 145.0 COG2329@1|root,COG2329@2|Bacteria,1RGVV@1224|Proteobacteria,2U9A3@28211|Alphaproteobacteria,34FS1@302485|Phaeobacter 28211|Alphaproteobacteria S Antibiotic biosynthesis monooxygenase - - - - - - - - - - - - ABM k59_777825_1 1458427.BAWN01000017_gene1125 6.21e-122 383.0 COG0591@1|root,COG0642@1|root,COG0591@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,2VKRS@28216|Betaproteobacteria,4AAXQ@80864|Comamonadaceae 28216|Betaproteobacteria T His Kinase A (phospho-acceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,PAS_7,Response_reg k59_607920_1 159087.Daro_0843 5.03e-39 135.0 COG0122@1|root,COG0122@2|Bacteria,1MX9C@1224|Proteobacteria,2VHMQ@28216|Betaproteobacteria,2KX76@206389|Rhodocyclales 206389|Rhodocyclales L endonuclease III - - 3.2.2.21 ko:K01247 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - HhH-GPD k59_607920_2 1192124.LIG30_3223 2.16e-45 155.0 COG0825@1|root,COG0825@2|Bacteria,1MURN@1224|Proteobacteria,2VHS0@28216|Betaproteobacteria,1K130@119060|Burkholderiaceae 28216|Betaproteobacteria I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA accA - 2.1.3.15,6.4.1.2 ko:K01962 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - ACCA k59_392341_1 113395.AXAI01000009_gene2622 3.11e-67 217.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TTM5@28211|Alphaproteobacteria,3JR50@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR). Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate frc - 2.8.3.16 ko:K07749 - - - - ko00000,ko01000 - - - CoA_transf_3 k59_607936_1 1121033.AUCF01000001_gene2386 1.02e-94 281.0 COG0745@1|root,COG0745@2|Bacteria,1MWVI@1224|Proteobacteria,2TRSP@28211|Alphaproteobacteria,2JPF5@204441|Rhodospirillales 204441|Rhodospirillales T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain ctrA - - ko:K13584 ko02020,ko04112,map02020,map04112 M00512 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_520655_1 391735.Veis_4886 1.07e-118 352.0 COG3335@1|root,COG3335@2|Bacteria,1MW7X@1224|Proteobacteria,2VMDX@28216|Betaproteobacteria,4AAP5@80864|Comamonadaceae 28216|Betaproteobacteria L PFAM Integrase catalytic region - - - - - - - - - - - - DDE_3,HTH_23,HTH_29,HTH_32 k59_608046_1 1500890.JQNL01000001_gene2973 8.45e-66 206.0 COG0655@1|root,COG0655@2|Bacteria,1MW7N@1224|Proteobacteria,1S23B@1236|Gammaproteobacteria,1X4PZ@135614|Xanthomonadales 135614|Xanthomonadales S Belongs to the WrbA family wrbA - 1.6.5.2 ko:K03809 ko00130,ko01110,map00130,map01110 - R02964,R03643,R03816 RC00819 ko00000,ko00001,ko01000 - - - FMN_red k59_608046_2 1121943.KB899993_gene62 9.06e-27 105.0 COG0593@1|root,COG0593@2|Bacteria,1MVW6@1224|Proteobacteria,1RPJP@1236|Gammaproteobacteria,1XJ85@135619|Oceanospirillales 135619|Oceanospirillales L Belongs to the DnaA family. HdA subfamily - - - ko:K10763 - - - - ko00000,ko03032 - - - Bac_DnaA k59_904300_1 419610.Mext_0237 1.11e-62 201.0 COG0745@1|root,COG0745@2|Bacteria,1MWZ5@1224|Proteobacteria,2TV3A@28211|Alphaproteobacteria,1JT9M@119045|Methylobacteriaceae 28211|Alphaproteobacteria T Transcriptional regulatory protein, C terminal kdpE - - ko:K07667 ko02020,ko02024,map02020,map02024 M00454 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_309715_1 373994.Riv7116_4067 4.74e-06 53.9 COG0517@1|root,COG0745@1|root,COG2202@1|root,COG3852@1|root,COG5002@1|root,COG0517@2|Bacteria,COG0745@2|Bacteria,COG2202@2|Bacteria,COG3852@2|Bacteria,COG5002@2|Bacteria,1GQW0@1117|Cyanobacteria 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_3,PAS_9,Response_reg k59_392469_1 497321.C664_17000 2.77e-152 436.0 COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,2VHAP@28216|Betaproteobacteria,2KVME@206389|Rhodocyclales 206389|Rhodocyclales M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan mraY - 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 - R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 - - Glycos_transf_4,MraY_sig1 k59_520738_2 1304275.C41B8_11553 1.45e-101 310.0 COG3425@1|root,COG3425@2|Bacteria,1MU4K@1224|Proteobacteria,1S16F@1236|Gammaproteobacteria 1236|Gammaproteobacteria I synthase - - 2.3.3.10 ko:K01641,ko:K15311 ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130 M00088,M00095 R01978 RC00004,RC00503 ko00000,ko00001,ko00002,ko01000,ko01008 - - - HMG_CoA_synt_C,HMG_CoA_synt_N k59_1305105_1 670292.JH26_05175 2.11e-05 49.3 COG1215@1|root,COG1215@2|Bacteria,1RIJ7@1224|Proteobacteria 1224|Proteobacteria M Pfam Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_1305105_2 43989.cce_2852 1.87e-18 86.7 COG0457@1|root,COG3914@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria,1G0YS@1117|Cyanobacteria 1117|Cyanobacteria O O-linked N-acetylglucosamine transferase SPINDLY family - - - - - - - - - - - - Glyco_transf_41,Sulfotransfer_2,TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_6,TPR_8 k59_495635_1 202952.BBLI01000012_gene1132 8.65e-50 170.0 COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,1RN65@1236|Gammaproteobacteria,3NJZB@468|Moraxellaceae 1236|Gammaproteobacteria K Belongs to the ParB family parB - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_152166_1 2340.JV46_14330 6.66e-60 204.0 COG1269@1|root,COG1269@2|Bacteria,1R6B8@1224|Proteobacteria,1RYT3@1236|Gammaproteobacteria 1236|Gammaproteobacteria U Belongs to the V-ATPase 116 kDa subunit family - - - ko:K02123 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - V_ATPase_I k59_538298_1 535289.Dtpsy_2823 5.1e-19 86.3 COG0414@1|root,COG0414@2|Bacteria,1MV1S@1224|Proteobacteria,2VHF1@28216|Betaproteobacteria,4A9TM@80864|Comamonadaceae 28216|Betaproteobacteria H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate panC - 6.3.2.1 ko:K01918 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R02473 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_ligase k59_1006939_1 1097668.BYI23_E002770 3.29e-42 143.0 COG0789@1|root,COG0789@2|Bacteria,1MZ3P@1224|Proteobacteria,2VVVQ@28216|Betaproteobacteria,1KEMJ@119060|Burkholderiaceae 28216|Betaproteobacteria K MerR, DNA binding - - - ko:K08365 - - - - ko00000,ko03000 - - - MerR,MerR-DNA-bind,MerR_1 k59_1352458_2 936455.KI421499_gene3153 2.21e-49 164.0 COG0614@1|root,COG0614@2|Bacteria,1PK1C@1224|Proteobacteria,2TRF4@28211|Alphaproteobacteria,3JUAC@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P Periplasmic binding protein - - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 k59_1305225_1 420662.Mpe_A2103 8.16e-99 296.0 COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,2VIQ5@28216|Betaproteobacteria,1KIUF@119065|unclassified Burkholderiales 28216|Betaproteobacteria H Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate ilvC - 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 - - - IlvC,IlvN k59_371998_2 1121403.AUCV01000066_gene4144 0.000254 45.1 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2MIB8@213118|Desulfobacterales 28221|Deltaproteobacteria T response regulator receiver - - - ko:K02481,ko:K07713 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_833081_1 1501230.ET33_37670 0.000123 45.4 COG1999@1|root,COG1999@2|Bacteria,1V03J@1239|Firmicutes,4HET3@91061|Bacilli,26WBW@186822|Paenibacillaceae 91061|Bacilli S SCO1/SenC ypmQ - - ko:K07152 - - - - ko00000,ko03029 - - - SCO1-SenC k59_1352525_2 1000565.METUNv1_00163 3.41e-167 473.0 COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,2VHR7@28216|Betaproteobacteria,2KUZJ@206389|Rhodocyclales 206389|Rhodocyclales E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family ilvE - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_1352536_1 693661.Arcve_0889 7.14e-77 236.0 COG1126@1|root,arCOG00923@2157|Archaea,2XVB5@28890|Euryarchaeota 28890|Euryarchaeota E COG1126 ABC-type polar amino acid transport system ATPase component glnQ - 3.6.3.21 ko:K02028 - M00236 - - ko00000,ko00002,ko01000,ko02000 3.A.1.3 - - ABC_tran k59_1263248_1 314278.NB231_10293 1.31e-57 204.0 COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,1RQVZ@1236|Gammaproteobacteria,1WW36@135613|Chromatiales 135613|Chromatiales E PFAM NAD-glutamate dehydrogenase - - 1.4.1.2 ko:K15371 ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100 - R00243 RC00006,RC02799 ko00000,ko00001,ko01000 - - - Bac_GDH k59_372050_1 1178482.BJB45_11020 4.1e-22 94.7 COG4948@1|root,COG4948@2|Bacteria,1MURK@1224|Proteobacteria,1RPIT@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Catalyzes the dehydration of D-galactonate to 2-keto-3- deoxy-D-galactonate - - 4.2.1.6 ko:K01684 ko00052,ko01100,ko01120,map00052,map01100,map01120 M00552 R03033 RC00543 ko00000,ko00001,ko00002,ko01000 - - - MR_MLE_C,MR_MLE_N k59_372050_2 360910.BAV0204 4.67e-56 181.0 COG3576@1|root,COG3576@2|Bacteria,1MWG9@1224|Proteobacteria,2VQ6P@28216|Betaproteobacteria,3T5FN@506|Alcaligenaceae 28216|Betaproteobacteria S Pyridoxamine 5'-phosphate oxidase - - - ko:K07006 - - - - ko00000 - - - Putative_PNPOx k59_708963_1 85643.Tmz1t_0278 1.26e-58 195.0 COG4372@1|root,COG4372@2|Bacteria,1MUCX@1224|Proteobacteria,2WGN9@28216|Betaproteobacteria 28216|Betaproteobacteria S transposase IS66 - - - ko:K07484 - - - - ko00000 - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66 k59_1263263_1 573370.DMR_24170 3.18e-05 50.8 COG4254@1|root,COG4254@2|Bacteria,1Q514@1224|Proteobacteria,43A3P@68525|delta/epsilon subdivisions,2X0YM@28221|Deltaproteobacteria,2MDSA@213115|Desulfovibrionales 28221|Deltaproteobacteria S FecR protein - - - - - - - - - - - - FecR k59_833140_1 983917.RGE_07870 8.04e-38 137.0 COG0466@1|root,COG0466@2|Bacteria,1MWQ9@1224|Proteobacteria,2VJKY@28216|Betaproteobacteria,1KJEZ@119065|unclassified Burkholderiales 28216|Betaproteobacteria O PFAM ATPase family associated with various cellular activities (AAA) - - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA k59_538428_1 56780.SYN_01324 1.31e-59 196.0 COG2199@1|root,COG3706@2|Bacteria,1RCC4@1224|Proteobacteria,43AED@68525|delta/epsilon subdivisions,2WQS7@28221|Deltaproteobacteria 1224|Proteobacteria T diguanylate cyclase - - - - - - - - - - - - GGDEF k59_29119_1 640081.Dsui_0378 8.54e-143 417.0 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2VI85@28216|Betaproteobacteria,2KVPK@206389|Rhodocyclales 206389|Rhodocyclales C FAD linked oxidases, C-terminal domain dldH - 1.1.2.4 ko:K00102 ko00620,map00620 - R00197 RC00044 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_280425_1 394.NGR_c27050 1.4e-06 50.4 COG3703@1|root,COG3703@2|Bacteria,1QA7D@1224|Proteobacteria,2U7C6@28211|Alphaproteobacteria,4BC5W@82115|Rhizobiaceae 28211|Alphaproteobacteria P Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides chaC - - ko:K07232 - - - - ko00000 - - - ChaC k59_280425_2 591158.SSMG_02415 1.5e-29 120.0 COG2368@1|root,COG2368@2|Bacteria,2GKIQ@201174|Actinobacteria 201174|Actinobacteria Q PFAM 4-hydroxyphenylacetate 3-hydroxylase - - 1.14.14.9 ko:K00483 ko00350,ko01120,ko01220,map00350,map01120,map01220 - R02698,R03299 RC00046 ko00000,ko00001,ko01000 - - - HpaB,HpaB_N k59_240170_1 1038858.AXBA01000005_gene4460 3.87e-93 299.0 COG1129@1|root,COG4177@1|root,COG1129@2|Bacteria,COG4177@2|Bacteria,1R9IW@1224|Proteobacteria,2TWGB@28211|Alphaproteobacteria,3F2EM@335928|Xanthobacteraceae 28211|Alphaproteobacteria E Branched-chain amino acid transport system / permease component - - - - - - - - - - - - ABC_tran,BCA_ABC_TP_C,BPD_transp_2 k59_922306_1 570967.JMLV01000005_gene81 6.19e-50 173.0 COG2801@1|root,COG2801@2|Bacteria,1N207@1224|Proteobacteria,2UEQQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - ko:K07497 - - - - ko00000 - - - HTH_28,HTH_32,rve,rve_3 k59_110040_1 267608.RSc1411 1.65e-27 115.0 COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,2VHBW@28216|Betaproteobacteria,1JZSU@119060|Burkholderiaceae 28216|Betaproteobacteria M zinc metalloprotease rseP - - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_M50 k59_372182_1 1382359.JIAL01000001_gene680 2.46e-91 280.0 COG0719@1|root,COG0719@2|Bacteria,3Y4EK@57723|Acidobacteria 57723|Acidobacteria O Uncharacterized protein family (UPF0051) - - - ko:K09015 - - - - ko00000 - - - UPF0051 k59_1263402_1 652103.Rpdx1_3435 1.09e-36 137.0 COG3278@1|root,COG3278@2|Bacteria,1PU2D@1224|Proteobacteria,2U5ID@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Belongs to the heme-copper respiratory oxidase family - - - - - - - - - - - - - k59_495958_1 234267.Acid_1409 2.38e-37 137.0 COG3745@1|root,COG3745@2|Bacteria,3Y4HR@57723|Acidobacteria 57723|Acidobacteria U PFAM SAF domain - - - ko:K02279 - - - - ko00000,ko02035,ko02044 - - - RcpC,SAF k59_453423_1 103690.17135310 7.36e-30 114.0 arCOG10456@1|root,2ZA6T@2|Bacteria,1G2PI@1117|Cyanobacteria,1HQPR@1161|Nostocales 1117|Cyanobacteria - - - - - - - - - - - - - - - k59_453423_2 2340.JV46_17870 6.9e-27 104.0 COG1765@1|root,COG1765@2|Bacteria,1N1RR@1224|Proteobacteria,1S3KI@1236|Gammaproteobacteria,1J71R@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O OsmC-like protein - - - - - - - - - - - - OsmC k59_372219_1 1112214.AHIS01000077_gene3824 9.65e-34 135.0 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,2TRFB@28211|Alphaproteobacteria,2K05M@204457|Sphingomonadales 204457|Sphingomonadales S Peptidase, M16 - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C k59_629580_1 1223521.BBJX01000002_gene2871 1.49e-82 259.0 COG2211@1|root,COG2211@2|Bacteria,1QTSE@1224|Proteobacteria,2WGIZ@28216|Betaproteobacteria,4A9M2@80864|Comamonadaceae 28216|Betaproteobacteria G Major facilitator superfamily ampG - - ko:K08218 ko01501,map01501 M00628 - - ko00000,ko00001,ko00002,ko02000 2.A.1.25 - - Acatn,MFS_1 k59_1056254_1 1000565.METUNv1_00166 3.89e-38 137.0 COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,2VJRR@28216|Betaproteobacteria,2KVQU@206389|Rhodocyclales 206389|Rhodocyclales J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 mnmA - 2.8.1.13 ko:K00566 ko04122,map04122 - R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 - - - tRNA_Me_trans k59_1056254_2 62928.azo2774 9.19e-21 87.4 COG1051@1|root,COG1051@2|Bacteria,1N03W@1224|Proteobacteria,2VRC0@28216|Betaproteobacteria,2KWI7@206389|Rhodocyclales 206389|Rhodocyclales F Belongs to the Nudix hydrolase family. NudJ subfamily nudJ - - - - - - - - - - - NUDIX k59_1056272_1 83344.XP_007928536.1 1.75e-17 84.3 COG2313@1|root,KOG3009@2759|Eukaryota,38BEH@33154|Opisthokonta,3NUN7@4751|Fungi,3QJY1@4890|Ascomycota,200HI@147541|Dothideomycetes,3MFXP@451867|Dothideomycetidae 4751|Fungi Q Indigoidine synthase A like protein - GO:0001522,GO:0003674,GO:0003824,GO:0004730,GO:0006139,GO:0006213,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009116,GO:0009451,GO:0009987,GO:0016070,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016829,GO:0016835,GO:0016836,GO:0034641,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050225,GO:0055086,GO:0071704,GO:0072527,GO:0090304,GO:1901135,GO:1901360,GO:1901564,GO:1901657 2.7.1.83,4.2.1.70 ko:K16329,ko:K16330 ko00240,map00240 - R01055,R03315 RC00002,RC00017,RC00432,RC00433 ko00000,ko00001,ko01000 - - - Indigoidine_A,PfkB k59_1056272_2 690850.Desaf_2414 4.23e-06 49.3 COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,42MET@68525|delta/epsilon subdivisions,2WITH@28221|Deltaproteobacteria,2M9RV@213115|Desulfovibrionales 28221|Deltaproteobacteria G Phosphoglucomutase phosphomannomutase, alpha beta alpha domain II algC - 5.4.2.2,5.4.2.8 ko:K01840,ko:K15778 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_1352809_1 631362.Thi970DRAFT_03536 1.22e-73 247.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,1WW84@135613|Chromatiales 135613|Chromatiales E Vitamin B12 dependent methionine synthase activation metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_922469_1 1121033.AUCF01000017_gene3778 2.06e-44 156.0 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria,2JPUA@204441|Rhodospirillales 204441|Rhodospirillales G COG1593 TRAP-type C4-dicarboxylate transport system, large permease component - - - - - - - - - - - - DctM k59_922469_2 1007105.PT7_2186 1.02e-18 83.2 COG3090@1|root,COG3090@2|Bacteria,1N7J6@1224|Proteobacteria 1224|Proteobacteria G Tripartite ATP-independent periplasmic transporters, DctQ component - - - - - - - - - - - - DctQ k59_922500_1 745776.DGo_CA2812 5.44e-11 68.6 COG2409@1|root,COG2409@2|Bacteria,1WJIE@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S COGs COG2409 drug exporter of the RND superfamily - - - ko:K06994 - - - - ko00000 - - - MMPL k59_197643_1 550540.Fbal_3033 1.33e-58 195.0 COG0786@1|root,COG0786@2|Bacteria,1MVBC@1224|Proteobacteria,1RP0S@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Catalyzes the sodium-dependent transport of glutamate gltS - - ko:K03312 - - - - ko00000,ko02000 2.A.27 - - Glt_symporter k59_1305683_1 1049564.TevJSym_at00530 5.29e-82 266.0 COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RN8P@1236|Gammaproteobacteria,1J8TN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties glgP - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - Phosphorylase k59_964912_1 1304877.KI519400_gene347 8.36e-80 256.0 COG0477@1|root,COG2814@2|Bacteria,1P3S4@1224|Proteobacteria,2TVAQ@28211|Alphaproteobacteria,3JTFE@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria EGP Transmembrane secretion effector - - - - - - - - - - - - MFS_1 k59_538727_1 345073.VC395_2803 1.58e-58 192.0 COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,1RNS2@1236|Gammaproteobacteria,1XSMN@135623|Vibrionales 135623|Vibrionales P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family fieF - - ko:K13283 - - - - ko00000,ko02000 2.A.4.7.1 - - Cation_efflux,ZT_dimer k59_1131912_1 224911.27356225 9.09e-110 329.0 COG3039@1|root,COG3039@2|Bacteria,1MVTU@1224|Proteobacteria,2TVIR@28211|Alphaproteobacteria,3JT6Q@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L hmm pf01609 - - - ko:K07481 - - - - ko00000 - - - DUF772 k59_629785_1 1288494.EBAPG3_6240 1.96e-107 320.0 COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,2VHBP@28216|Betaproteobacteria,371XV@32003|Nitrosomonadales 28216|Betaproteobacteria J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines dusB - - ko:K05540 - - - - ko00000,ko01000,ko03016 - - - Dus k59_876551_1 999547.KI421500_gene3551 1.79e-46 160.0 COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,2TTXT@28211|Alphaproteobacteria,2823D@191028|Leisingera 28211|Alphaproteobacteria L Phage integrase family - - - - - - - - - - - - Phage_int_SAM_4,Phage_integrase k59_876551_2 999547.KI421500_gene3551 1e-52 176.0 COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,2TTXT@28211|Alphaproteobacteria,2823D@191028|Leisingera 28211|Alphaproteobacteria L Phage integrase family - - - - - - - - - - - - Phage_int_SAM_4,Phage_integrase k59_922615_1 573370.DMR_02050 2.4e-79 259.0 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,42MPZ@68525|delta/epsilon subdivisions,2WIR9@28221|Deltaproteobacteria,2M99R@213115|Desulfovibrionales 28221|Deltaproteobacteria J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_751984_1 313606.M23134_03401 2.27e-16 82.8 COG1301@1|root,COG1301@2|Bacteria,4NDUU@976|Bacteroidetes,47KI1@768503|Cytophagia 976|Bacteroidetes C Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family gltP - - ko:K11102,ko:K11103 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.23.1.1,2.A.23.1.2,2.A.23.1.3,2.A.23.1.6,2.A.23.1.7 - - SDF k59_453692_1 671143.DAMO_3131 2e-29 113.0 COG1077@1|root,COG1077@2|Bacteria,2NNVU@2323|unclassified Bacteria 2|Bacteria D MreB/Mbl protein mreB GO:0000003,GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005856,GO:0005886,GO:0007049,GO:0008150,GO:0008360,GO:0009987,GO:0016020,GO:0019954,GO:0022402,GO:0022414,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0032505,GO:0042802,GO:0043093,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051301,GO:0051302,GO:0051782,GO:0051983,GO:0065007,GO:0065008,GO:0071944 - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl k59_453692_2 671143.DAMO_3131 1.97e-85 261.0 COG1077@1|root,COG1077@2|Bacteria,2NNVU@2323|unclassified Bacteria 2|Bacteria D MreB/Mbl protein mreB GO:0000003,GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005856,GO:0005886,GO:0007049,GO:0008150,GO:0008360,GO:0009987,GO:0016020,GO:0019954,GO:0022402,GO:0022414,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0032505,GO:0042802,GO:0043093,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051301,GO:0051302,GO:0051782,GO:0051983,GO:0065007,GO:0065008,GO:0071944 - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl k59_334727_1 1379270.AUXF01000003_gene3597 4.46e-11 66.6 COG0845@1|root,COG0845@2|Bacteria 2|Bacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K01993,ko:K16922 - - - - ko00000,ko01002 - - - HlyD_3 k59_1012929_1 436308.Nmar_1729 1.29e-93 282.0 COG0371@1|root,arCOG00982@2157|Archaea,41T0B@651137|Thaumarchaeota 651137|Thaumarchaeota C Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea egsA - 1.1.1.261 ko:K00096 ko00564,map00564 - R05679,R05680 RC00029 ko00000,ko00001,ko01000 - - - Fe-ADH_2 k59_714941_1 1380380.JIAX01000010_gene127 5.86e-34 132.0 COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,2TRKK@28211|Alphaproteobacteria 28211|Alphaproteobacteria M mechanosensitive ion channel MA20_40450 - - - - - - - - - - - MS_channel k59_246577_1 95619.PM1_0224510 1.26e-21 100.0 COG2911@1|root,COG2931@1|root,COG2982@1|root,COG2911@2|Bacteria,COG2931@2|Bacteria,COG2982@2|Bacteria,1MU7T@1224|Proteobacteria,1RNK8@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q COG2931 RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - DUF4214,DUF4347,He_PIG,HemolysinCabind,PA14,VWA_2 k59_1311786_1 1197906.CAJQ02000011_gene835 5.31e-54 178.0 COG1024@1|root,COG1024@2|Bacteria,1MVQN@1224|Proteobacteria,2TUXD@28211|Alphaproteobacteria,3JSP8@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I enoyl-CoA hydratase - - 5.3.3.18 ko:K15866 ko00360,ko01120,map00360,map01120 - R09837,R09839 RC00004,RC00326,RC02689,RC03003 ko00000,ko00001,ko01000 - - - ECH_1 k59_1311786_2 85643.Tmz1t_1515 5.06e-09 56.2 COG0663@1|root,COG0663@2|Bacteria,1MVUI@1224|Proteobacteria,2VH4Y@28216|Betaproteobacteria,2KUST@206389|Rhodocyclales 206389|Rhodocyclales S Phenylacetic acid degradation protein PaaY - - - ko:K02617 - - - - ko00000 - - - Hexapep k59_1358557_1 419610.Mext_4804 9.57e-84 259.0 COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,2TQXI@28211|Alphaproteobacteria,1JR7J@119045|Methylobacteriaceae 28211|Alphaproteobacteria E 5-aminolevulinic acid synthase hemA - 2.3.1.37 ko:K00643 ko00260,ko00860,ko01100,ko01110,map00260,map00860,map01100,map01110 - R00830 RC00004,RC02815 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_928289_1 1229780.BN381_60022 4.14e-102 300.0 COG0450@1|root,COG0450@2|Bacteria,2GM74@201174|Actinobacteria 201174|Actinobacteria O alkyl hydroperoxide reductase - - 1.11.1.15 ko:K03386 ko04214,map04214 - - - ko00000,ko00001,ko01000,ko04147 - - - 1-cysPrx_C,AhpC-TSA k59_501849_1 1123073.KB899241_gene3163 7e-16 84.0 COG3166@1|root,COG3166@2|Bacteria,1RJTG@1224|Proteobacteria,1S6RT@1236|Gammaproteobacteria,1X4P5@135614|Xanthomonadales 135614|Xanthomonadales NU General secretion pathway protein xpsL - - ko:K02461 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - PilN,T2SSL k59_1136797_1 314278.NB231_12309 1.17e-61 210.0 COG1305@1|root,COG1305@2|Bacteria,1MWCE@1224|Proteobacteria,1RPH9@1236|Gammaproteobacteria,1WXJ3@135613|Chromatiales 135613|Chromatiales E PFAM Transglutaminase-like - - 2.3.2.13 ko:K22452 - - - - ko00000,ko01000 - - - DUF3488,DUF4129,Transglut_core k59_970640_1 232721.Ajs_3464 2.7e-80 263.0 COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,2VJG2@28216|Betaproteobacteria,4ACV8@80864|Comamonadaceae 28216|Betaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family fdhA - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_970651_1 998088.B565_2743 1.68e-20 95.5 COG0715@1|root,COG2199@1|root,COG0715@2|Bacteria,COG2199@2|Bacteria,1RGCV@1224|Proteobacteria,1T48W@1236|Gammaproteobacteria,1Y5B3@135624|Aeromonadales 135624|Aeromonadales PT Hemerythrin HHE cation binding domain - - - - - - - - - - - - GGDEF,Hemerythrin,NMT1,PAS_4,PAS_9 k59_1311868_1 266265.Bxe_A1635 1.13e-30 115.0 COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,2VIHE@28216|Betaproteobacteria,1JZV9@119060|Burkholderiaceae 28216|Betaproteobacteria I Enoyl- acyl-carrier-protein reductase NADH fabI - 1.3.1.10,1.3.1.9 ko:K00208 ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212 M00083,M00572 R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671 RC00052,RC00076,RC00120 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_1311868_2 1121106.JQKB01000080_gene2757 5.67e-99 298.0 COG4948@1|root,COG4948@2|Bacteria,1MW3F@1224|Proteobacteria,2U1H9@28211|Alphaproteobacteria,2JYT0@204441|Rhodospirillales 204441|Rhodospirillales M Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - - - - - - - - - - MR_MLE_C,MR_MLE_N k59_757570_1 1288298.rosmuc_03652 1.16e-89 265.0 COG2080@1|root,COG2080@2|Bacteria,1RB3F@1224|Proteobacteria,2VF0C@28211|Alphaproteobacteria,46QDA@74030|Roseovarius 28211|Alphaproteobacteria C COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS CutS homologs - - 1.2.5.3 ko:K03518 - - R11168 RC02800 ko00000,ko01000 - - - Fer2,Fer2_2 k59_1105359_1 1120956.JHZK01000030_gene6 2.05e-144 421.0 COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,2TRMR@28211|Alphaproteobacteria,1JN89@119043|Rhodobiaceae 28211|Alphaproteobacteria C Transketolase, pyrimidine binding domain pdhB - 1.2.4.1 ko:K00162 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Biotin_lipoyl,Transket_pyr,Transketolase_C k59_1013047_1 316055.RPE_1638 6.21e-65 201.0 COG0454@1|root,COG0454@2|Bacteria,1RHV9@1224|Proteobacteria,2U96G@28211|Alphaproteobacteria,3K4UA@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_10,Acetyltransf_7 k59_1013047_2 1207063.P24_18179 2.92e-58 191.0 COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,2TQXH@28211|Alphaproteobacteria,2JQXD@204441|Rhodospirillales 204441|Rhodospirillales Q Multicopper oxidase - - - - - - - - - - - - Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3 k59_246687_1 471856.Jden_0827 9.71e-34 130.0 COG1079@1|root,COG1079@2|Bacteria,2GKMB@201174|Actinobacteria 201174|Actinobacteria S Belongs to the binding-protein-dependent transport system permease family - - - ko:K02057 - M00221 - - ko00000,ko00002,ko02000 3.A.1.2 - - BPD_transp_2 k59_928376_1 1207063.P24_16375 4.19e-58 191.0 COG0683@1|root,COG0683@2|Bacteria,1Q1P3@1224|Proteobacteria,2TUJG@28211|Alphaproteobacteria,2JVUV@204441|Rhodospirillales 204441|Rhodospirillales E Receptor family ligand binding region - - - - - - - - - - - - Peripla_BP_6 k59_928376_2 1207063.P24_16370 7.88e-93 279.0 COG0411@1|root,COG0411@2|Bacteria,1MVAU@1224|Proteobacteria,2TVRN@28211|Alphaproteobacteria,2JVDX@204441|Rhodospirillales 204441|Rhodospirillales E ATPases associated with a variety of cellular activities - - - - - - - - - - - - ABC_tran,BCA_ABC_TP_C k59_970706_1 1121441.AUCX01000009_gene2407 4.23e-21 89.0 COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,42U0T@68525|delta/epsilon subdivisions,2WPUW@28221|Deltaproteobacteria,2MC6E@213115|Desulfovibrionales 28221|Deltaproteobacteria O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_838367_1 1341151.ASZU01000012_gene1687 2.41e-89 278.0 COG2987@1|root,COG2987@2|Bacteria,1TPZ9@1239|Firmicutes,4H9NH@91061|Bacilli,27BE2@186824|Thermoactinomycetaceae 91061|Bacilli E Urocanase C-terminal domain hutU - 4.2.1.49 ko:K01712 ko00340,ko01100,map00340,map01100 M00045 R02914 RC00804 ko00000,ko00001,ko00002,ko01000 - - - Urocanase,Urocanase_C,Urocanase_N k59_501955_1 864051.BurJ1DRAFT_4740 0.000616 45.4 COG1024@1|root,COG1024@2|Bacteria,1MVEC@1224|Proteobacteria,2VI5G@28216|Betaproteobacteria,1KJZJ@119065|unclassified Burkholderiales 28216|Betaproteobacteria I enoyl-CoA hydratase - - 4.2.1.18 ko:K13766,ko:K15312 ko00280,ko01100,map00280,map01100 M00036 R02085 RC02416 ko00000,ko00001,ko00002,ko01000,ko01008 - - - ECH_1 k59_501955_2 196490.AUEZ01000022_gene901 7.07e-12 65.9 COG4948@1|root,COG4948@2|Bacteria,1MYZE@1224|Proteobacteria,2TU3A@28211|Alphaproteobacteria,3JW29@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M Mandelate racemase / muconate lactonizing enzyme, C-terminal domain MA20_06335 - 4.2.1.156,4.2.1.42,5.1.2.2 ko:K01781,ko:K20023 ko00053,ko00627,ko01120,map00053,map00627,map01120 - R03791,R04161,R05608 RC00543,RC00998 ko00000,ko00001,ko01000 - - - MR_MLE_C,MR_MLE_N k59_38319_1 204669.Acid345_1627 6.99e-74 237.0 COG0477@1|root,COG0477@2|Bacteria,3Y4JA@57723|Acidobacteria,2JJBX@204432|Acidobacteriia 204432|Acidobacteriia EGP Sugar (and other) transporter - - - - - - - - - - - - Sugar_tr k59_760544_1 1300350.DSW25_03925 1.37e-06 50.4 28I8Y@1|root,2Z8BR@2|Bacteria,1MXN1@1224|Proteobacteria,2TRAQ@28211|Alphaproteobacteria,3ZVEZ@60136|Sulfitobacter 28211|Alphaproteobacteria S Protein of unknown function (DUF1638) - - - - - - - - - - - - DUF1638 k59_760544_2 748247.AZKH_p0167 8.76e-27 102.0 2CDZD@1|root,32RYT@2|Bacteria,1N0AT@1224|Proteobacteria 1224|Proteobacteria S Virulence factor - - - - - - - - - - - - Virulence_fact k59_760544_3 247639.MGP2080_08801 1.49e-62 196.0 COG0685@1|root,COG0685@2|Bacteria,1RHDY@1224|Proteobacteria,1T0DC@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Methylene-tetrahydrofolate reductase C terminal - - - - - - - - - - - - MTHFR_C k59_760544_4 247633.GP2143_05705 9e-55 180.0 COG0685@1|root,COG0685@2|Bacteria,1MXTZ@1224|Proteobacteria,1S185@1236|Gammaproteobacteria 1236|Gammaproteobacteria E COG0685 5,10-methylenetetrahydrofolate reductase - - 1.5.1.20 ko:K00297 ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523 M00377 R01224,R07168 RC00081 ko00000,ko00001,ko00002,ko01000 - - - MTHFR k59_587848_1 1463825.JNXC01000020_gene6689 2.39e-28 113.0 COG1816@1|root,COG1816@2|Bacteria,2GJ6I@201174|Actinobacteria,4DZ10@85010|Pseudonocardiales 201174|Actinobacteria F PFAM Adenosine AMP deaminase add GO:0003674,GO:0003824,GO:0004000,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006144,GO:0006152,GO:0006154,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009116,GO:0009119,GO:0009163,GO:0009164,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0042440,GO:0042451,GO:0042454,GO:0042455,GO:0042737,GO:0043094,GO:0043096,GO:0043101,GO:0043103,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046085,GO:0046100,GO:0046101,GO:0046102,GO:0046103,GO:0046112,GO:0046128,GO:0046129,GO:0046130,GO:0046148,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:1901135,GO:1901136,GO:1901137,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658,GO:1901659 3.5.4.4 ko:K01488 ko00230,ko01100,ko05340,map00230,map01100,map05340 - R01560,R02556 RC00477 ko00000,ko00001,ko01000 - - iNJ661.Rv3313c A_deaminase k59_587848_2 977880.RALTA_B0470 5.63e-05 47.4 COG2267@1|root,COG2267@2|Bacteria,1N03H@1224|Proteobacteria,2VM76@28216|Betaproteobacteria,1K4RR@119060|Burkholderiaceae 28216|Betaproteobacteria I Poly(3-hydroxyalkanoate) depolymerase - - 3.1.1.76 ko:K22250 - - - - ko00000,ko01000 - - - Abhydrolase_1 k59_676056_2 1336208.JADY01000026_gene2282 3.29e-57 188.0 COG0028@1|root,COG0028@2|Bacteria,1R6QP@1224|Proteobacteria,2TUEF@28211|Alphaproteobacteria,2JVP8@204441|Rhodospirillales 204441|Rhodospirillales EH Thiamine pyrophosphate enzyme, N-terminal TPP binding domain - - 4.1.1.82 ko:K09459 ko00440,ko01100,ko01120,ko01130,map00440,map01100,map01120,map01130 - R04053 RC00506 ko00000,ko00001,ko01000 - - - TPP_enzyme_C,TPP_enzyme_N k59_420412_1 1173264.KI913949_gene2954 2.79e-65 208.0 COG0854@1|root,COG0854@2|Bacteria,1G0QW@1117|Cyanobacteria,1H8WB@1150|Oscillatoriales 1117|Cyanobacteria H Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate pdxJ GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.6.99.2 ko:K03474 ko00750,ko01100,map00750,map01100 M00124 R05838 RC01476 ko00000,ko00001,ko00002,ko01000 - - - PdxJ k59_119207_1 1304872.JAGC01000003_gene2980 2.97e-35 134.0 COG1360@1|root,COG1360@2|Bacteria,1MU4S@1224|Proteobacteria,42T2J@68525|delta/epsilon subdivisions,2WPPV@28221|Deltaproteobacteria,2MG6T@213115|Desulfovibrionales 28221|Deltaproteobacteria N OmpA family - - - ko:K02557 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - OmpA k59_931427_2 572265.HDEF_1660 4.83e-19 86.3 28J2E@1|root,2Z8YX@2|Bacteria,1REPW@1224|Proteobacteria,1S4IX@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF2815) - - - - - - - - - - - - DUF2815 k59_718138_1 1238182.C882_4005 1.41e-48 166.0 COG1733@1|root,COG1733@2|Bacteria,1NEKW@1224|Proteobacteria,2U0MC@28211|Alphaproteobacteria,2JSVH@204441|Rhodospirillales 204441|Rhodospirillales K HxlR-like helix-turn-helix - - - - - - - - - - - - HxlR k59_973740_1 550540.Fbal_2464 5.8e-19 84.3 COG2755@1|root,COG2755@2|Bacteria,1RE1B@1224|Proteobacteria,1S42Y@1236|Gammaproteobacteria 1236|Gammaproteobacteria E COG2755 Lysophospholipase L1 and related esterases - - - - - - - - - - - - Lipase_GDSL_2 k59_1187136_1 652103.Rpdx1_4135 3.09e-67 222.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria,3JWY5@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria IQ AMP-binding enzyme - - - ko:K04116 ko00362,ko01120,map00362,map01120 M00540 R05620 RC00004,RC01438 ko00000,ko00001,ko00002,ko01000 - - - AMP-binding,AMP-binding_C k59_381228_1 768671.ThimaDRAFT_1939 3.83e-106 319.0 COG1861@1|root,COG1861@2|Bacteria,1QU5J@1224|Proteobacteria,1T5B6@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Transposase DDE domain group 1 - - - - - - - - - - - - DDE_Tnp_1_4 k59_1187193_1 1121106.JQKB01000014_gene5718 3.08e-29 113.0 COG0251@1|root,COG0251@2|Bacteria,1N1B6@1224|Proteobacteria,2TZWE@28211|Alphaproteobacteria 28211|Alphaproteobacteria J oxidation-reduction process - - - - - - - - - - - - - k59_1187193_2 1207063.P24_16355 1.07e-30 117.0 COG4177@1|root,COG4177@2|Bacteria,1PAW4@1224|Proteobacteria,2U0EY@28211|Alphaproteobacteria,2JZAV@204441|Rhodospirillales 204441|Rhodospirillales E Branched-chain amino acid transport system / permease component - - - - - - - - - - - - BPD_transp_2 k59_676207_1 1458427.BAWN01000059_gene2185 9.03e-22 95.1 COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,2VH46@28216|Betaproteobacteria,4AAD0@80864|Comamonadaceae 28216|Betaproteobacteria M Belongs to the peptidase S11 family dacC - 3.4.16.4 ko:K07258 ko00550,ko01100,map00550,map01100 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - PBP5_C,Peptidase_S11 k59_676207_2 85643.Tmz1t_0241 9.3e-58 190.0 COG0797@1|root,COG3087@1|root,COG0797@2|Bacteria,COG3087@2|Bacteria,1MZ8S@1224|Proteobacteria,2VJAN@28216|Betaproteobacteria,2KUPW@206389|Rhodocyclales 206389|Rhodocyclales DM Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides rlpA - - ko:K03642 - - - - ko00000 - - - DPBB_1,SPOR k59_338024_1 1207063.P24_13208 7.76e-78 242.0 COG2515@1|root,COG2515@2|Bacteria,1MVYF@1224|Proteobacteria,2TRCB@28211|Alphaproteobacteria,2JPJQ@204441|Rhodospirillales 204441|Rhodospirillales E Pyridoxal-phosphate dependent enzyme - - - - - - - - - - - - PALP k59_1016250_1 1121921.KB898706_gene3122 2.26e-54 187.0 28N9P@1|root,2ZBDN@2|Bacteria,1R70P@1224|Proteobacteria,1RQ5R@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF3592) - - - - - - - - - - - - DUF3592 k59_1230084_1 1382304.JNIL01000001_gene91 6.14e-93 278.0 COG0447@1|root,COG0447@2|Bacteria,1UHNU@1239|Firmicutes,4HAD0@91061|Bacilli 91061|Bacilli H Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) menB - 4.1.3.36 ko:K01661 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R07263 RC01923 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_119400_2 292415.Tbd_2695 1.35e-48 162.0 COG2518@1|root,COG2518@2|Bacteria,1RD6S@1224|Proteobacteria,2VJX3@28216|Betaproteobacteria,1KRWY@119069|Hydrogenophilales 119069|Hydrogenophilales O Ribosomal RNA adenine dimethylase - - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT k59_807510_1 748247.AZKH_2215 2.88e-121 361.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VPRI@28216|Betaproteobacteria 28216|Betaproteobacteria T PFAM sigma-54 factor interaction domain-containing protein - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_462717_1 795666.MW7_3397 1.14e-26 107.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2VI6D@28216|Betaproteobacteria,1K5TM@119060|Burkholderiaceae 28216|Betaproteobacteria C Fumarate reductase flavoprotein C-term - - 1.3.5.1,1.3.5.4 ko:K00239,ko:K00244 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,ko05134,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020,map05134 M00009,M00011,M00149,M00150,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_462717_2 1007105.PT7_2623 5e-120 365.0 COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2VHUG@28216|Betaproteobacteria,3T6UJ@506|Alcaligenaceae 28216|Betaproteobacteria S Domain of unknown function (DUF3394) - - - - - - - - - - - - DUF3394,DctM k59_588114_1 1123504.JQKD01000006_gene1432 6.69e-56 186.0 COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,2VIIQ@28216|Betaproteobacteria,4ADS6@80864|Comamonadaceae 28216|Betaproteobacteria C dehydrogenase, E1 component pdhA - 1.2.4.1 ko:K00161,ko:K21416 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh k59_588114_2 365046.Rta_29510 2.32e-97 292.0 COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,2VKQ0@28216|Betaproteobacteria,4ACTU@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM Transketolase central region - - 1.2.4.1 ko:K00162,ko:K21417 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C k59_718358_1 1231190.NA8A_11208 1.65e-23 103.0 COG3210@1|root,COG3210@2|Bacteria,1MXIP@1224|Proteobacteria,2TTVB@28211|Alphaproteobacteria,43NKB@69277|Phyllobacteriaceae 28211|Alphaproteobacteria U COG3210 Large exoproteins involved in heme utilization or adhesion - - - - - - - - - - - - DUF3739,Haemagg_act k59_760846_1 1122614.JHZF01000020_gene163 2.41e-97 288.0 COG1024@1|root,COG1024@2|Bacteria,1MVJJ@1224|Proteobacteria,2U0AD@28211|Alphaproteobacteria,2PEYW@252301|Oceanicola 28211|Alphaproteobacteria I Enoyl-CoA hydratase/isomerase - - - - - - - - - - - - ECH_1 k59_884383_2 331869.BAL199_26502 1.82e-22 95.1 COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,2TR8S@28211|Alphaproteobacteria,4BP88@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) trpD GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18,4.1.3.27 ko:K00766,ko:K13497 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R00985,R00986,R01073 RC00010,RC00440,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Glycos_trans_3N,Glycos_transf_3 k59_1315204_1 688245.CtCNB1_1767 1.53e-54 174.0 COG0346@1|root,COG0346@2|Bacteria,1RH3J@1224|Proteobacteria,2VRD4@28216|Betaproteobacteria,4AEJW@80864|Comamonadaceae 28216|Betaproteobacteria E PFAM Glyoxalase bleomycin resistance protein dioxygenase gloA3 - - - - - - - - - - - Glyoxalase k59_1315204_2 1240349.ANGC01000024_gene3610 2.16e-09 60.5 COG4757@1|root,COG4757@2|Bacteria,2ICF8@201174|Actinobacteria,4FW53@85025|Nocardiaceae 201174|Actinobacteria S Serine aminopeptidase, S33 - - - - - - - - - - - - Abhydrolase_1,Hydrolase_4 k59_1315236_1 1484158.PSNIH1_13560 3.29e-17 85.5 COG0477@1|root,COG2814@2|Bacteria,1MX2Q@1224|Proteobacteria,1RR66@1236|Gammaproteobacteria,3VYAI@53335|Pantoea 1236|Gammaproteobacteria EGP Transporter emrY - - - - - - - - - - - MFS_1,Sugar_tr k59_931784_1 1000565.METUNv1_02451 1.38e-140 424.0 COG0515@1|root,COG4252@1|root,COG0515@2|Bacteria,COG4252@2|Bacteria,1MV1P@1224|Proteobacteria,2VKJ8@28216|Betaproteobacteria,2KV51@206389|Rhodocyclales 206389|Rhodocyclales KLT Protein tyrosine kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - CHASE2,Pkinase k59_338245_1 1005048.CFU_4426 1.37e-118 358.0 COG1274@1|root,COG1274@2|Bacteria,1MX3C@1224|Proteobacteria,2VINZ@28216|Betaproteobacteria,472VX@75682|Oxalobacteraceae 28216|Betaproteobacteria H Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle pckG GO:0000003,GO:0001655,GO:0001822,GO:0001889,GO:0003006,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004457,GO:0004611,GO:0004613,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005975,GO:0005996,GO:0006006,GO:0006007,GO:0006066,GO:0006071,GO:0006082,GO:0006089,GO:0006090,GO:0006091,GO:0006094,GO:0006109,GO:0006111,GO:0006113,GO:0006139,GO:0006163,GO:0006464,GO:0006629,GO:0006631,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006735,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007028,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007296,GO:0007610,GO:0008150,GO:0008152,GO:0008906,GO:0009056,GO:0009058,GO:0009062,GO:0009117,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009166,GO:0009167,GO:0009179,GO:0009185,GO:0009199,GO:0009205,GO:0009259,GO:0009410,GO:0009605,GO:0009636,GO:0009653,GO:0009719,GO:0009725,GO:0009790,GO:0009792,GO:0009887,GO:0009888,GO:0009889,GO:0009966,GO:0009967,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010646,GO:0010647,GO:0010675,GO:0010906,GO:0014070,GO:0014074,GO:0015036,GO:0015980,GO:0016042,GO:0016043,GO:0016051,GO:0016052,GO:0016053,GO:0016054,GO:0016301,GO:0016310,GO:0016491,GO:0016614,GO:0016651,GO:0016667,GO:0016668,GO:0016740,GO:0016772,GO:0016773,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017001,GO:0017144,GO:0018130,GO:0018991,GO:0019098,GO:0019222,GO:0019249,GO:0019318,GO:0019319,GO:0019320,GO:0019362,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019516,GO:0019538,GO:0019541,GO:0019543,GO:0019563,GO:0019626,GO:0019637,GO:0019659,GO:0019660,GO:0019661,GO:0019666,GO:0019674,GO:0019693,GO:0019751,GO:0019752,GO:0019953,GO:0022412,GO:0022414,GO:0023051,GO:0023056,GO:0030145,GO:0030154,GO:0030703,GO:0030855,GO:0031323,GO:0031667,GO:0031960,GO:0031974,GO:0032501,GO:0032502,GO:0032504,GO:0032787,GO:0032868,GO:0032869,GO:0032870,GO:0033993,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035690,GO:0036211,GO:0042221,GO:0042493,GO:0042594,GO:0042737,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043255,GO:0043412,GO:0043434,GO:0043436,GO:0043687,GO:0043900,GO:0043903,GO:0043949,GO:0043950,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044267,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0045471,GO:0046031,GO:0046034,GO:0046164,GO:0046174,GO:0046364,GO:0046365,GO:0046394,GO:0046395,GO:0046434,GO:0046459,GO:0046483,GO:0046496,GO:0046677,GO:0046683,GO:0046700,GO:0046872,GO:0046914,GO:0047134,GO:0048468,GO:0048477,GO:0048513,GO:0048518,GO:0048522,GO:0048545,GO:0048562,GO:0048568,GO:0048583,GO:0048584,GO:0048598,GO:0048609,GO:0048646,GO:0048731,GO:0048732,GO:0048856,GO:0048869,GO:0050789,GO:0050792,GO:0050794,GO:0050896,GO:0051186,GO:0051384,GO:0051591,GO:0051704,GO:0051716,GO:0055086,GO:0055114,GO:0060429,GO:0061005,GO:0061008,GO:0062012,GO:0065007,GO:0070013,GO:0070365,GO:0070887,GO:0071236,GO:0071310,GO:0071361,GO:0071375,GO:0071383,GO:0071384,GO:0071385,GO:0071396,GO:0071407,GO:0071417,GO:0071466,GO:0071495,GO:0071548,GO:0071549,GO:0071704,GO:0071840,GO:0072001,GO:0072071,GO:0072329,GO:0072330,GO:0072521,GO:0072524,GO:0080090,GO:0097159,GO:0097237,GO:0097305,GO:0097306,GO:0097327,GO:1901135,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901575,GO:1901576,GO:1901615,GO:1901616,GO:1901617,GO:1901652,GO:1901653,GO:1901654,GO:1901655,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902531,GO:1902533 4.1.1.32 ko:K01596 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964 M00003 R00431,R00726 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPCK_C,PEPCK_N k59_297793_2 1123487.KB892857_gene2414 3.09e-08 53.1 COG0236@1|root,COG0236@2|Bacteria,1NFPT@1224|Proteobacteria,2VX2W@28216|Betaproteobacteria,2KXAB@206389|Rhodocyclales 206389|Rhodocyclales IQ Phosphopantetheine attachment site - - - ko:K02078 - - - - ko00000,ko00001 - - - PP-binding k59_596206_1 1115515.EV102420_23_00290 4.27e-13 69.3 COG0277@1|root,COG0277@2|Bacteria,1MUPW@1224|Proteobacteria,1RRDD@1236|Gammaproteobacteria 1236|Gammaproteobacteria C FAD linked oxidase domain protein - - - - - - - - - - - - BBE,FAD_binding_4 k59_297879_1 1318628.MARLIPOL_09421 1.19e-11 66.2 COG1281@1|root,COG1281@2|Bacteria,1MUMU@1224|Proteobacteria,1RMP3@1236|Gammaproteobacteria,466I9@72275|Alteromonadaceae 1236|Gammaproteobacteria O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress hslO GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006950,GO:0006979,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0031647,GO:0036506,GO:0042026,GO:0042802,GO:0043167,GO:0043169,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0065007,GO:0065008 - ko:K04083 - - - - ko00000,ko03110 - - - HSP33 k59_297879_2 1304872.JAGC01000009_gene1301 5.41e-30 115.0 COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,42N83@68525|delta/epsilon subdivisions,2WJFF@28221|Deltaproteobacteria,2M90C@213115|Desulfovibrionales 28221|Deltaproteobacteria V PFAM ABC-2 type transporter - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 k59_1146478_1 981383.AEWH01000024_gene2699 4.25e-29 115.0 COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,4HAH6@91061|Bacilli 91061|Bacilli EP COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components - - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_1146480_1 1458275.AZ34_04075 3.14e-156 452.0 COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,2VIDR@28216|Betaproteobacteria,4AAKQ@80864|Comamonadaceae 28216|Betaproteobacteria C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane pntB - 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB k59_891971_1 414684.RC1_0633 2.34e-21 99.8 COG0784@1|root,COG4251@1|root,COG5278@1|root,COG0784@2|Bacteria,COG4251@2|Bacteria,COG5278@2|Bacteria,1NC9X@1224|Proteobacteria,2TYBZ@28211|Alphaproteobacteria,2JYXR@204441|Rhodospirillales 204441|Rhodospirillales T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS_7,Response_reg k59_298189_1 1100720.ALKN01000043_gene2689 2.87e-67 214.0 COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,2VMVX@28216|Betaproteobacteria,4A9VB@80864|Comamonadaceae 28216|Betaproteobacteria C Zinc-binding dehydrogenase - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_170166_1 913865.DOT_1508 1.96e-45 167.0 COG0493@1|root,COG3383@1|root,COG0493@2|Bacteria,COG3383@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,26166@186807|Peptococcaceae 186801|Clostridia C Pyridine nucleotide-disulphide oxidoreductase - - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_20,Fer4_6,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Pyr_redox_2,Pyr_redox_3 k59_892274_1 1434319.W5RV68_9CAUD 8.74e-25 99.0 4QBHW@10239|Viruses,4QW8N@35237|dsDNA viruses no RNA stage,4QTT7@28883|Caudovirales,4QN92@10699|Siphoviridae 10699|Siphoviridae S sequence-specific DNA binding transcription factor activity - - - - - - - - - - - - - k59_1146940_2 395494.Galf_1199 1.57e-56 195.0 COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,2VIDE@28216|Betaproteobacteria,44VJW@713636|Nitrosomonadales 28216|Betaproteobacteria L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA - 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 k59_848465_1 479432.Sros_7224 7.46e-08 53.1 COG0300@1|root,COG0300@2|Bacteria,2GK2K@201174|Actinobacteria,4EME6@85012|Streptosporangiales 201174|Actinobacteria S Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short k59_848465_2 1218074.BAXZ01000006_gene1751 5.16e-67 215.0 COG1960@1|root,COG1960@2|Bacteria,1MU2V@1224|Proteobacteria,2VI1V@28216|Betaproteobacteria,1K0CZ@119060|Burkholderiaceae 28216|Betaproteobacteria I Acyl-CoA dehydrogenase, C-terminal domain - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_892382_1 1410608.JNKX01000052_gene1502 3.86e-30 122.0 COG3385@1|root,COG3385@2|Bacteria,4NXT2@976|Bacteroidetes,2FRVS@200643|Bacteroidia 976|Bacteroidetes L hmm pf01609 - - - - - - - - - - - - DDE_Tnp_1_4 k59_170349_1 555778.Hneap_1753 1.21e-57 196.0 COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,1RMCI@1236|Gammaproteobacteria,1WXIB@135613|Chromatiales 135613|Chromatiales L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parE - - ko:K02622 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_170395_2 502025.Hoch_6117 1.08e-13 71.2 COG4301@1|root,COG4301@2|Bacteria,1MUCG@1224|Proteobacteria,42SR8@68525|delta/epsilon subdivisions,2WPN0@28221|Deltaproteobacteria,2Z0GW@29|Myxococcales 28221|Deltaproteobacteria S Histidine-specific methyltransferase, SAM-dependent - - 2.1.1.44 ko:K18911 ko00340,map00340 - R01169 RC00003,RC02308 ko00000,ko00001,ko01000 - - - Methyltransf_33 k59_170484_1 522306.CAP2UW1_3592 1.99e-80 243.0 COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,2VJQA@28216|Betaproteobacteria,1KPZK@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria K Belongs to the UPF0301 (AlgH) family algH - - ko:K07735 - - - - ko00000,ko03000 - - - DUF179 k59_170484_2 1163617.SCD_n00211 2.31e-07 51.2 COG0816@1|root,COG0816@2|Bacteria,1RDHZ@1224|Proteobacteria,2VUH0@28216|Betaproteobacteria 28216|Betaproteobacteria J Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA yqgF - - ko:K07447 - - - - ko00000,ko01000 - - - RuvX k59_892710_1 604331.AUHY01000074_gene1811 1.89e-63 207.0 COG3328@1|root,COG3328@2|Bacteria,1WN6I@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus L MULE transposase domain - - - - - - - - - - - - Transposase_mut k59_1147426_1 246197.MXAN_5515 6.28e-27 110.0 COG3016@1|root,COG3016@2|Bacteria,1MX1I@1224|Proteobacteria,42U2R@68525|delta/epsilon subdivisions,2WM9S@28221|Deltaproteobacteria,2YZVS@29|Myxococcales 28221|Deltaproteobacteria S Haem-binding uptake, Tiki superfamily, ChaN - - - - - - - - - - - - Cofac_haem_bdg,PDZ_2 k59_849415_1 1276756.AUEX01000010_gene1597 1.21e-82 277.0 COG0457@1|root,COG3914@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria,1MVMG@1224|Proteobacteria,2VH3M@28216|Betaproteobacteria,4ABFW@80864|Comamonadaceae 28216|Betaproteobacteria O SMART Tetratricopeptide - - - - - - - - - - - - Glyco_transf_41,TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8 k59_1147827_1 1031711.RSPO_c03297 2.11e-89 285.0 COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,2VHBZ@28216|Betaproteobacteria,1K061@119060|Burkholderiaceae 28216|Betaproteobacteria M Catalyzes cross-linking of the peptidoglycan cell wall mrdA - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase k59_893789_1 1504981.KO116_3199 3.48e-43 158.0 COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,1RMH7@1236|Gammaproteobacteria,1XNKW@135619|Oceanospirillales 135619|Oceanospirillales S TRAP transporter, 4TM 12TM fusion protein - - - - - - - - - - - - DctM k59_849564_1 267608.RSc2010 3.14e-24 98.6 COG1569@1|root,COG1569@2|Bacteria,1NASM@1224|Proteobacteria,2VVUB@28216|Betaproteobacteria,1K7NV@119060|Burkholderiaceae 28216|Betaproteobacteria S PIN domain - - - - - - - - - - - - PIN_3 k59_1148007_1 155864.EDL933_0248 4.15e-47 166.0 COG5433@1|root,COG5433@2|Bacteria,1MXB5@1224|Proteobacteria,1RSAV@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Transposase yncI - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_assoc k59_849655_1 62928.azo2012 1.47e-24 102.0 COG0443@1|root,COG0443@2|Bacteria,1MVQI@1224|Proteobacteria,2VHGV@28216|Betaproteobacteria,2KUV2@206389|Rhodocyclales 206389|Rhodocyclales O Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB hscA - - ko:K04044 - - - - ko00000,ko03110 1.A.33 - - HSP70 k59_849655_2 279714.FuraDRAFT_0544 1.52e-14 72.4 COG1076@1|root,COG1076@2|Bacteria,1RHZX@1224|Proteobacteria,2VSD5@28216|Betaproteobacteria,2KR7U@206351|Neisseriales 206351|Neisseriales O Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA hscB - - ko:K04082 - - - - ko00000,ko03029,ko03110 - - - DnaJ,HSCB_C k59_849669_1 1227495.C487_04103 9.61e-14 75.9 COG0405@1|root,arCOG04053@2157|Archaea,2XUEX@28890|Euryarchaeota,23T05@183963|Halobacteria 183963|Halobacteria E COG0405 Gamma-glutamyltransferase - - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_1148029_1 1511.CLOST_1160 4.14e-11 63.5 COG0369@1|root,COG1151@2|Bacteria,1TRSC@1239|Firmicutes,248HQ@186801|Clostridia,25S5F@186804|Peptostreptococcaceae 186801|Clostridia C Prismane/CO dehydrogenase family cooS1 - 1.2.7.4 ko:K00198 ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200 M00377 R07157,R08034 RC00250,RC02800 ko00000,ko00001,ko00002,ko01000 - - - Prismane k59_1148029_2 374847.Kcr_0762 3.79e-29 117.0 COG1151@1|root,arCOG02429@2157|Archaea 2157|Archaea C TIGRFAM carbon-monoxide dehydrogenase, catalytic subunit - - 1.2.7.4 ko:K00198 ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200 M00377 R07157,R08034 RC00250,RC02800 ko00000,ko00001,ko00002,ko01000 - - - Prismane k59_1148114_2 762376.AXYL_01492 1.25e-30 118.0 COG2175@1|root,COG2175@2|Bacteria,1MV5K@1224|Proteobacteria,2VHIY@28216|Betaproteobacteria,3T1K3@506|Alcaligenaceae 28216|Betaproteobacteria Q taurine catabolism dioxygenase - - - - - - - - - - - - TauD k59_894303_1 279714.FuraDRAFT_2654 0.000687 43.5 COG0500@1|root,COG2226@2|Bacteria,1PA5F@1224|Proteobacteria,2VJP9@28216|Betaproteobacteria,2KU4J@206351|Neisseriales 206351|Neisseriales H Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway bioC - 2.1.1.197 ko:K02169 ko00780,ko01100,map00780,map01100 M00572 R09543 RC00003,RC00460 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_11 k59_894303_2 105559.Nwat_3100 1.16e-08 57.8 COG5488@1|root,COG5488@2|Bacteria,1N9B7@1224|Proteobacteria,1SF1J@1236|Gammaproteobacteria,1X1FG@135613|Chromatiales 135613|Chromatiales S Integral membrane protein (DUF2244) - - - - - - - - - - - - DUF2244 k59_1009235_2 1392838.AWNM01000043_gene1588 1.45e-44 149.0 COG1430@1|root,COG1430@2|Bacteria,1MZBJ@1224|Proteobacteria,2VSCK@28216|Betaproteobacteria,3T4GB@506|Alcaligenaceae 28216|Betaproteobacteria S Uncharacterized ACR, COG1430 - - - ko:K09005 - - - - ko00000 - - - DUF192 k59_924491_1 742740.HMPREF9474_03204 1.58e-21 95.9 COG3333@1|root,COG3333@2|Bacteria,1TPE7@1239|Firmicutes,247UH@186801|Clostridia,21XFS@1506553|Lachnoclostridium 186801|Clostridia S Tripartite tricarboxylate transporter TctA family - - - ko:K07793 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.80.1 - - TctA k59_924491_2 1304877.KI519399_gene4281 2.32e-11 63.5 2BKYI@1|root,32FF5@2|Bacteria,1RB6X@1224|Proteobacteria,2VER9@28211|Alphaproteobacteria,3JY0I@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Tripartite tricarboxylate transporter TctB family MA20_15120 - - - - - - - - - - - TctB k59_1100869_1 373994.Riv7116_5757 2e-12 71.2 COG0642@1|root,COG0784@1|root,COG1196@1|root,COG1352@1|root,COG2201@1|root,COG5002@1|root,COG0784@2|Bacteria,COG1196@2|Bacteria,COG1352@2|Bacteria,COG2201@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1G09B@1117|Cyanobacteria,1HTV6@1161|Nostocales 1117|Cyanobacteria T Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - 2.1.1.80,3.1.1.61 ko:K03320,ko:K13924 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02000,ko02022,ko02035 1.A.11 - - CheB_methylest,CheR,CheR_N,HATPase_c,HisKA,PAS_10,PAS_4,Response_reg k59_455517_1 1282876.BAOK01000001_gene1872 2e-142 428.0 COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,2TQRQ@28211|Alphaproteobacteria,4BP77@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parC - - ko:K02621 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseA_C,DNA_topoisoIV k59_199584_1 1198452.Jab_1c18330 7.01e-26 111.0 COG1629@1|root,COG4771@2|Bacteria,1RA71@1224|Proteobacteria,2WGMC@28216|Betaproteobacteria,473R3@75682|Oxalobacteraceae 28216|Betaproteobacteria P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_632055_1 760117.JN27_21420 5.66e-83 264.0 COG3219@1|root,COG3220@1|root,COG3219@2|Bacteria,COG3220@2|Bacteria,1MURE@1224|Proteobacteria,2VKD3@28216|Betaproteobacteria,475Z0@75682|Oxalobacteraceae 28216|Betaproteobacteria S Protein of unknown function (DUF692) - - - ko:K09930 - - - - ko00000 - - - DUF2063,DUF692 k59_632055_2 626418.bglu_2p0940 2.4e-17 77.0 COG5572@1|root,COG5572@2|Bacteria,1MZ6Q@1224|Proteobacteria,2VWC8@28216|Betaproteobacteria,1K9JZ@119060|Burkholderiaceae 28216|Betaproteobacteria S Predicted integral membrane protein (DUF2282) - - - - - - - - - - - - DUF2282 k59_1308040_1 1265502.KB905945_gene654 3.6e-48 162.0 COG1028@1|root,COG1028@2|Bacteria,1MUFX@1224|Proteobacteria,2VMB3@28216|Betaproteobacteria,4ACE3@80864|Comamonadaceae 28216|Betaproteobacteria IQ PFAM Short-chain dehydrogenase reductase SDR tsaC GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0010130,GO:0016043,GO:0016491,GO:0016614,GO:0016616,GO:0018913,GO:0018915,GO:0022607,GO:0042537,GO:0043933,GO:0044085,GO:0044237,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:1901360 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_924527_1 1031711.RSPO_c03064 2.81e-14 68.9 COG2960@1|root,COG2960@2|Bacteria,1N7AH@1224|Proteobacteria,2VVR4@28216|Betaproteobacteria,1K9GB@119060|Burkholderiaceae 28216|Betaproteobacteria S Membrane fusogenic activity yqiC - - ko:K09806 - - - - ko00000 - - - BMFP k59_31388_2 1118060.CAGZ01000030_gene1090 3.78e-17 83.6 COG0812@1|root,COG0812@2|Bacteria,2GIV2@201174|Actinobacteria,4CUE7@84998|Coriobacteriia 84998|Coriobacteriia M Cell wall formation murB - 1.3.1.98 ko:K00075 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R03191,R03192 RC02639 ko00000,ko00001,ko01000,ko01011 - - - FAD_binding_4,MurB_C k59_800554_1 1382304.JNIL01000001_gene550 1.38e-36 138.0 COG0595@1|root,COG0595@2|Bacteria,1TQ9G@1239|Firmicutes,4HAAP@91061|Bacilli,277WB@186823|Alicyclobacillaceae 91061|Bacilli S An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay rnj - - ko:K12574 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - Lactamase_B,RMMBL k59_242839_1 118173.KB235914_gene2616 2.49e-47 172.0 COG2304@1|root,COG2304@2|Bacteria,1GQAG@1117|Cyanobacteria,1H979@1150|Oscillatoriales 1117|Cyanobacteria T protein containing a von Willebrand factor type A (vWA) domain - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VIT,VWA_3 k59_242852_1 395493.BegalDRAFT_0712 8.36e-50 173.0 COG0651@1|root,COG0651@2|Bacteria,1MVBA@1224|Proteobacteria,1RPB3@1236|Gammaproteobacteria 1236|Gammaproteobacteria CP PFAM NADH Ubiquinone plastoquinone hyfF GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0033554,GO:0044425,GO:0044464,GO:0050896,GO:0051716,GO:0071944 - ko:K12141 - - - - ko00000,ko01000 - - iECIAI39_1322.ECIAI39_2625,iZ_1308.Z3746 Proton_antipo_M,Proton_antipo_N k59_242852_2 395493.BegalDRAFT_0661 4.18e-29 111.0 COG4237@1|root,COG4237@2|Bacteria,1NAT8@1224|Proteobacteria,1RRYF@1236|Gammaproteobacteria 1236|Gammaproteobacteria C hydrogenase 4 membrane hyfE GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K12140 - - - - ko00000,ko01000 - - - Oxidored_q2 k59_881868_1 1415779.JOMH01000001_gene961 1.79e-15 73.2 COG1937@1|root,COG1937@2|Bacteria,1NFTB@1224|Proteobacteria,1T084@1236|Gammaproteobacteria,1X8EH@135614|Xanthomonadales 135614|Xanthomonadales S Metal-sensitive transcriptional repressor - - - - - - - - - - - - Trns_repr_metal k59_881868_2 85643.Tmz1t_2791 4.79e-30 107.0 COG0425@1|root,COG0425@2|Bacteria,1MZA5@1224|Proteobacteria,2VVW5@28216|Betaproteobacteria,2KWXB@206389|Rhodocyclales 206389|Rhodocyclales O Belongs to the sulfur carrier protein TusA family - - - ko:K04085 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - TusA k59_1063695_1 1123247.AUIJ01000041_gene300 1.35e-105 312.0 COG0500@1|root,COG2226@2|Bacteria,1PPKI@1224|Proteobacteria,2TRIB@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q Methyltransferase - - - - - - - - - - - - Methyltransf_25,Methyltransf_31 k59_35736_1 264732.Moth_0461 2.55e-17 81.6 COG0682@1|root,COG0682@2|Bacteria,1TPAK@1239|Firmicutes,24APG@186801|Clostridia,42FG7@68295|Thermoanaerobacterales 186801|Clostridia M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins lgt - - ko:K13292 - - - - ko00000,ko01000 - - - LGT k59_35736_2 1230342.CTM_01015 6.25e-15 75.9 COG0772@1|root,COG0772@2|Bacteria,1TPGH@1239|Firmicutes,247WS@186801|Clostridia,36EC8@31979|Clostridiaceae 186801|Clostridia D Belongs to the SEDS family rodA - - ko:K05837 - - - - ko00000,ko03036 - - - FTSW_RODA_SPOVE k59_417870_1 1312954.KI914890_gene2263 7.89e-05 50.1 COG0785@1|root,COG2128@1|root,COG0785@2|Bacteria,COG2128@2|Bacteria,2IK3K@201174|Actinobacteria 201174|Actinobacteria O Cytochrome C biogenesis protein transmembrane region - - - - - - - - - - - - DsbD k59_1137242_1 1385517.N800_06160 1.89e-61 208.0 COG4805@1|root,COG4805@2|Bacteria,1R5EP@1224|Proteobacteria,1RRS6@1236|Gammaproteobacteria,1X3WH@135614|Xanthomonadales 135614|Xanthomonadales S Bacterial protein of unknown function (DUF885) - - - - - - - - - - - - DUF885 k59_971161_1 690585.JNNU01000009_gene471 2.94e-40 146.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TSB1@28211|Alphaproteobacteria,4B84V@82115|Rhizobiaceae 28211|Alphaproteobacteria EH Belongs to the TPP enzyme family ilvG - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_971161_2 314260.PB2503_10479 2.43e-44 147.0 COG0727@1|root,COG0727@2|Bacteria,1N5PC@1224|Proteobacteria,2UFEE@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Putative zinc- or iron-chelating domain - - - ko:K06940 - - - - ko00000 - - - CxxCxxCC k59_203867_1 2340.JV46_09260 7.2e-21 96.7 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,1RNCU@1236|Gammaproteobacteria,1J4G0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd GO:0000715,GO:0000716,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006283,GO:0006289,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008094,GO:0008150,GO:0008152,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031326,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0043175,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051276,GO:0051716,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_585338_1 316067.Geob_0077 3.61e-53 183.0 COG2204@1|root,COG2204@2|Bacteria,1QYWF@1224|Proteobacteria,43CD6@68525|delta/epsilon subdivisions,2X7P0@28221|Deltaproteobacteria 28221|Deltaproteobacteria K PFAM sigma-54 factor interaction domain-containing protein - - - - - - - - - - - - Sigma54_activat k59_1269844_1 999541.bgla_1g33390 1.22e-90 272.0 COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,2VH1U@28216|Betaproteobacteria,1K2NF@119060|Burkholderiaceae 28216|Betaproteobacteria C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit sucD GO:0003674,GO:0003824,GO:0004774,GO:0004776,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0016874,GO:0016877,GO:0016878,GO:0031974,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0070013 6.2.1.5 ko:K01902 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - CoA_binding,Ligase_CoA k59_673580_1 1439940.BAY1663_03239 0.000182 44.3 COG0384@1|root,COG0384@2|Bacteria,1MUAS@1224|Proteobacteria,1RPWM@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Phenazine biosynthesis protein PhzF pab - - - - - - - - - - - PhzC-PhzF k59_673580_2 1242864.D187_004713 7.13e-79 241.0 COG0778@1|root,COG0778@2|Bacteria,1R9VX@1224|Proteobacteria,42M0E@68525|delta/epsilon subdivisions,2WV66@28221|Deltaproteobacteria,2YZ5C@29|Myxococcales 28221|Deltaproteobacteria C NADH dehydrogenase NAD(P)H nitroreductase - - - ko:K09019 ko00240,ko01100,map00240,map01100 - R09289 RC00087 ko00000,ko00001,ko01000 - - - Nitroreductase k59_673580_3 1122611.KB903956_gene220 1.97e-82 261.0 COG0427@1|root,COG0427@2|Bacteria,2IAMG@201174|Actinobacteria,4EPQF@85012|Streptosporangiales 201174|Actinobacteria C Acetyl-CoA hydrolase/transferase C-terminal domain - - - - - - - - - - - - AcetylCoA_hyd_C,AcetylCoA_hydro k59_838798_1 1121012.AUKX01000007_gene183 9.22e-25 107.0 COG2133@1|root,COG2133@2|Bacteria,4NH6W@976|Bacteroidetes,1I07N@117743|Flavobacteriia,23GBN@178469|Arenibacter 976|Bacteroidetes G Cytochrome c - - - - - - - - - - - - Cytochrom_C k59_545044_1 1246474.ANBE01000050_gene1531 9.1e-62 204.0 COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4EG29@85012|Streptosporangiales 201174|Actinobacteria IQ AMP-binding enzyme C-terminal domain - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_1359196_1 1120999.JONM01000002_gene977 3.05e-06 50.1 COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,2VHFD@28216|Betaproteobacteria,2KPFF@206351|Neisseriales 206351|Neisseriales J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS - 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD k59_1359196_2 1452718.JBOY01000001_gene548 6.26e-48 158.0 COG0735@1|root,COG0735@2|Bacteria,1MZIW@1224|Proteobacteria,1S5ZI@1236|Gammaproteobacteria 1236|Gammaproteobacteria P belongs to the Fur family zur - - ko:K09823 ko02024,map02024 - - - ko00000,ko00001,ko03000 - - - FUR k59_1106017_1 1469245.JFBG01000069_gene33 1.04e-18 86.3 COG0477@1|root,COG2814@2|Bacteria 2|Bacteria EGP Major facilitator Superfamily - - - - - - - - - - - - MFS_1,MFS_3 k59_502522_1 62928.azo3134 1.62e-69 235.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,2KV6Z@206389|Rhodocyclales 206389|Rhodocyclales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_882031_1 1121035.AUCH01000003_gene1204 8.44e-82 263.0 COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2VHQQ@28216|Betaproteobacteria,2KUCM@206389|Rhodocyclales 206389|Rhodocyclales P Belongs to the monovalent cation proton antiporter 2 (cpa2) transporter (TC 2.A.37) family - - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger,TrkA_C,TrkA_N k59_758205_1 883078.HMPREF9695_03279 2.42e-105 315.0 COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,2TSD0@28211|Alphaproteobacteria,3JTGD@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria G Phosphofructokinase pfkA - 2.7.1.11,2.7.1.90 ko:K00850,ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230 M00001,M00345 R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko01009,ko03019 - - - PFK k59_1184695_2 1304883.KI912532_gene870 2.04e-30 114.0 2EAZV@1|root,3350Q@2|Bacteria,1P6NQ@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_1312551_1 977880.RALTA_A1323 1.56e-143 423.0 COG1024@1|root,COG1024@2|Bacteria,1N817@1224|Proteobacteria,2VKSK@28216|Betaproteobacteria 28216|Betaproteobacteria I enoyl-CoA hydratase boxC - 4.1.2.44 ko:K15513 ko00362,map00362 - R09556 RC03426 ko00000,ko00001,ko01000 - - - ECH_1 k59_1184700_1 187272.Mlg_0695 8.32e-14 70.1 COG1633@1|root,COG1633@2|Bacteria,1RJFW@1224|Proteobacteria,1S85V@1236|Gammaproteobacteria,1WZFW@135613|Chromatiales 135613|Chromatiales S Rubrerythrin - - - - - - - - - - - - Rubrerythrin k59_1184700_2 114615.BRADO4292 2.35e-57 191.0 COG2175@1|root,COG2175@2|Bacteria,1MV5K@1224|Proteobacteria,2TQTZ@28211|Alphaproteobacteria,3JWFY@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria Q Taurine catabolism dioxygenase TauD, TfdA family MA20_23235 - 1.14.11.17 ko:K03119 ko00430,ko00920,map00430,map00920 - R05320 RC01331 ko00000,ko00001,ko01000 - - - TauD k59_116858_1 666681.M301_0651 7.12e-36 130.0 COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,2VHG9@28216|Betaproteobacteria,2KM77@206350|Nitrosomonadales 206350|Nitrosomonadales F aspartate ornithine carbamoyltransferase, carbamoyl-P binding domain pyrB - 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_116858_2 887062.HGR_10330 4.99e-42 149.0 COG0044@1|root,COG0044@2|Bacteria,1MVXY@1224|Proteobacteria,2VH1E@28216|Betaproteobacteria,4AA5D@80864|Comamonadaceae 28216|Betaproteobacteria F PFAM amidohydrolase pyrX - 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1,Amidohydro_3 k59_35995_1 1255043.TVNIR_1306 7.43e-25 103.0 COG3118@1|root,COG3118@2|Bacteria 2|Bacteria O belongs to the thioredoxin family ybbN GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - ko:K03671,ko:K05838 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - TPR_19,TPR_20,Thioredoxin k59_35995_2 264199.stu0048 4e-08 55.1 COG1438@1|root,COG1438@2|Bacteria,1V1R7@1239|Firmicutes,4HFY8@91061|Bacilli 91061|Bacilli K Regulates arginine biosynthesis genes argR - - ko:K03402 - - - - ko00000,ko03000 - - - Arg_repressor,Arg_repressor_C k59_1312592_1 1265505.ATUG01000003_gene803 1.61e-06 54.3 COG0845@1|root,COG0845@2|Bacteria,1RI9S@1224|Proteobacteria,42PDM@68525|delta/epsilon subdivisions,2WMKT@28221|Deltaproteobacteria,2MJBG@213118|Desulfobacterales 28221|Deltaproteobacteria M Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - - - - - - - - - - HlyD_D23 k59_1106202_1 1037409.BJ6T_87550 1.35e-25 109.0 COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,3JR8W@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Adenylate cyclase - - - - - - - - - - - - Guanylate_cyc,Trans_reg_C k59_637361_1 859657.RPSI07_2939 2.2e-53 185.0 COG0318@1|root,COG0764@1|root,COG0318@2|Bacteria,COG0764@2|Bacteria,1MXPB@1224|Proteobacteria,2VJ3A@28216|Betaproteobacteria,1KH0W@119060|Burkholderiaceae 28216|Betaproteobacteria IQ AMP-binding enzyme - - - - - - - - - - - - AMP-binding,AMP-binding_C,FabA k59_1106254_1 1392838.AWNM01000071_gene560 5.34e-178 519.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,2VNZD@28216|Betaproteobacteria,3T6RV@506|Alcaligenaceae 28216|Betaproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon2 - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_287266_1 269796.Rru_A0602 3.71e-64 205.0 COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,2TQMN@28211|Alphaproteobacteria,2JPN3@204441|Rhodospirillales 204441|Rhodospirillales P Plays a role in the regulation of phosphate uptake phoU - - ko:K02039 - - - - ko00000 - - - PhoU k59_1359460_1 911239.CF149_16566 1.02e-60 197.0 COG0559@1|root,COG0559@2|Bacteria,1MYEW@1224|Proteobacteria 1224|Proteobacteria E Belongs to the binding-protein-dependent transport system permease family - - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_1359460_2 331869.BAL199_26217 8.11e-105 315.0 COG4177@1|root,COG4177@2|Bacteria,1QF6I@1224|Proteobacteria,2TRTF@28211|Alphaproteobacteria,4BS7G@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E Branched-chain amino acid transport system / permease component - - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_971481_1 196490.AUEZ01000186_gene1407 8.66e-102 306.0 COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,2TUQT@28211|Alphaproteobacteria,3JXY7@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L MULE transposase domain - - - ko:K07493 - - - - ko00000 - - - Transposase_mut k59_1064146_1 748247.AZKH_0353 2.56e-38 150.0 COG0457@1|root,COG0457@2|Bacteria,1NFQW@1224|Proteobacteria,2VX93@28216|Betaproteobacteria,2KXPI@206389|Rhodocyclales 206389|Rhodocyclales S TPR repeat - - - - - - - - - - - - TPR_16,TPR_8 k59_116979_1 596151.DesfrDRAFT_1425 0.000387 46.6 COG0457@1|root,COG0457@2|Bacteria,1Q86T@1224|Proteobacteria,435ZC@68525|delta/epsilon subdivisions,2X0GM@28221|Deltaproteobacteria,2MC9X@213115|Desulfovibrionales 28221|Deltaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_1,TPR_8 k59_637443_1 384765.SIAM614_22717 9.57e-72 229.0 COG3547@1|root,COG3547@2|Bacteria,1MW0N@1224|Proteobacteria,2TUGE@28211|Alphaproteobacteria 28211|Alphaproteobacteria L PFAM transposase IS116 IS110 IS902 family - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_1270180_1 1123393.KB891326_gene83 9.8e-130 386.0 COG1387@1|root,COG1387@2|Bacteria,1MYXV@1224|Proteobacteria,2VJIQ@28216|Betaproteobacteria,1KSJ5@119069|Hydrogenophilales 119069|Hydrogenophilales L DNA polymerase X family - - - ko:K02347 - - - - ko00000,ko03400 - - - DNA_pol_B_thumb,HHH_5,HHH_8 k59_335716_1 1469245.JFBG01000023_gene1270 7.96e-75 246.0 COG0398@1|root,COG1249@1|root,COG0398@2|Bacteria,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RQTU@1236|Gammaproteobacteria,1X2Q6@135613|Chromatiales 135613|Chromatiales C SNARE associated Golgi protein - - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim,SNARE_assoc k59_839086_1 580332.Slit_1269 1.72e-70 227.0 COG2114@1|root,COG2114@2|Bacteria,1RD0X@1224|Proteobacteria,2VS0D@28216|Betaproteobacteria,44VWF@713636|Nitrosomonadales 28216|Betaproteobacteria T adenylyl cyclase class-3 4 guanylyl cyclase - - - - - - - - - - - - Guanylate_cyc,PEGA k59_839086_2 391625.PPSIR1_37774 1.08e-05 46.6 COG1670@1|root,COG1670@2|Bacteria,1MXEE@1224|Proteobacteria,433GE@68525|delta/epsilon subdivisions,2WYHA@28221|Deltaproteobacteria,2YVI4@29|Myxococcales 28221|Deltaproteobacteria J Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_3 k59_839097_1 1266914.ATUK01000015_gene849 8.96e-55 180.0 COG1018@1|root,COG1018@2|Bacteria,1MW37@1224|Proteobacteria,1RR95@1236|Gammaproteobacteria,1WVUK@135613|Chromatiales 135613|Chromatiales C PFAM oxidoreductase FAD NAD(P)-binding domain protein - - 1.18.1.2,1.19.1.1 ko:K00528 - - R10159 - ko00000,ko01000 - - - FAD_binding_6,NAD_binding_1 k59_673964_1 76114.ebA2271 6.9e-65 212.0 COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,2VI3M@28216|Betaproteobacteria,2KVC9@206389|Rhodocyclales 206389|Rhodocyclales E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine lysA - 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_379025_1 204773.HEAR2856 6.28e-77 236.0 COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,2VHBM@28216|Betaproteobacteria,472M5@75682|Oxalobacteraceae 28216|Betaproteobacteria H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) ubiE - 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Ubie_methyltran k59_1106390_2 1038858.AXBA01000013_gene2315 1.13e-47 163.0 COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,2TTJV@28211|Alphaproteobacteria,3EXX9@335928|Xanthobacteraceae 28211|Alphaproteobacteria C D-isomer specific 2-hydroxyacid dehydrogenase catalytic region gyaR1 - - - - - - - - - - - 2-Hacid_dh,2-Hacid_dh_C k59_204275_1 1231190.NA8A_01400 8.05e-43 141.0 COG0184@1|root,COG0184@2|Bacteria,1MZ2W@1224|Proteobacteria,2UBRZ@28211|Alphaproteobacteria,43KCG@69277|Phyllobacteriaceae 28211|Alphaproteobacteria J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome rpsO GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02956 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S15 k59_204275_2 1528106.JRJE01000032_gene2754 7e-08 54.3 COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,2TSJK@28211|Alphaproteobacteria,2JQHY@204441|Rhodospirillales 204441|Rhodospirillales J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs truB - 5.4.99.25 ko:K03177 - - - - ko00000,ko01000,ko03016 - - - TruB-C_2,TruB_C_2,TruB_N k59_1137617_1 545243.BAEV01000108_gene2769 7.74e-18 85.5 COG1682@1|root,COG1682@2|Bacteria,1TY8I@1239|Firmicutes,25B42@186801|Clostridia,36W8R@31979|Clostridiaceae 186801|Clostridia U Transport permease protein - - - ko:K01992,ko:K09690 ko02010,map02010 M00250,M00254 - - ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.103 - - ABC2_membrane k59_81018_1 314285.KT71_06267 1.81e-12 69.7 28M5H@1|root,2ZAJ9@2|Bacteria,1RJY2@1224|Proteobacteria,1SM8E@1236|Gammaproteobacteria,1J7EK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_117080_1 504832.OCAR_6061 9.03e-49 165.0 COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2TR4W@28211|Alphaproteobacteria,3JRM9@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Pyridoxal-phosphate dependent enzyme cysB GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_117080_2 748658.KB907319_gene780 8.19e-19 82.8 COG0494@1|root,COG0494@2|Bacteria,1RDMW@1224|Proteobacteria,1RPZV@1236|Gammaproteobacteria,1WYQS@135613|Chromatiales 135613|Chromatiales L PFAM NUDIX hydrolase - - 3.6.1.13 ko:K01515 ko00230,map00230 - R01054 RC00002 ko00000,ko00001,ko01000 - - - NUDIX k59_287409_1 247634.GPB2148_974 2.02e-34 128.0 COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,1RNS2@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family fieF GO:0000041,GO:0003674,GO:0005215,GO:0005381,GO:0005385,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006826,GO:0006829,GO:0006873,GO:0006875,GO:0006876,GO:0006882,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015086,GO:0015093,GO:0015291,GO:0015318,GO:0015341,GO:0015562,GO:0015684,GO:0015691,GO:0016020,GO:0019725,GO:0022804,GO:0022857,GO:0022883,GO:0022890,GO:0030001,GO:0030003,GO:0034220,GO:0034755,GO:0042592,GO:0042802,GO:0044464,GO:0046583,GO:0046873,GO:0046915,GO:0046916,GO:0048878,GO:0050801,GO:0051179,GO:0051234,GO:0055065,GO:0055069,GO:0055073,GO:0055076,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0070574,GO:0070838,GO:0071577,GO:0071944,GO:0072503,GO:0072507,GO:0072509,GO:0072511,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:1903874 - ko:K13283 - - - - ko00000,ko02000 2.A.4.7.1 - - Cation_efflux,ZT_dimer k59_287409_2 1121033.AUCF01000006_gene4283 5.69e-20 90.5 COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,1MU9M@1224|Proteobacteria,2TQJN@28211|Alphaproteobacteria,2JPG5@204441|Rhodospirillales 204441|Rhodospirillales S AAA domain - - - ko:K07028 - - - - ko00000 - - - AAA_33,APH k59_81053_1 1218076.BAYB01000030_gene4926 2.2e-20 89.4 COG0220@1|root,COG0220@2|Bacteria,1QTX5@1224|Proteobacteria,2WH0A@28216|Betaproteobacteria,1K3DS@119060|Burkholderiaceae 28216|Betaproteobacteria J Protein of unknown function (DUF938) - - - - - - - - - - - - DUF938 k59_287422_1 767434.Fraau_0210 5.44e-05 50.1 COG3659@1|root,COG3659@2|Bacteria,1R71M@1224|Proteobacteria,1S128@1236|Gammaproteobacteria,1X72H@135614|Xanthomonadales 135614|Xanthomonadales M Carbohydrate-selective porin, OprB family - - - ko:K07267 - - - - ko00000,ko02000 1.B.19.1 - - OprB k59_1137659_1 926569.ANT_04140 4.68e-66 223.0 COG0542@1|root,COG0542@2|Bacteria,2G62D@200795|Chloroflexi 200795|Chloroflexi O ATPase associated with various cellular activities, AAA_5 - - - ko:K03696 ko01100,map01100 - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_1064314_2 1366050.N234_06920 2.54e-32 120.0 COG0778@1|root,COG0778@2|Bacteria,1PG8V@1224|Proteobacteria,2VKIZ@28216|Betaproteobacteria,1K24T@119060|Burkholderiaceae 28216|Betaproteobacteria C nitroreductase nfnB - - - - - - - - - - - Nitroreductase k59_1227815_1 331869.BAL199_12576 4e-53 177.0 COG1744@1|root,COG1744@2|Bacteria,1NGHH@1224|Proteobacteria,2TR36@28211|Alphaproteobacteria,4BPN7@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria M ABC transporter substrate-binding protein PnrA-like tmpC - - ko:K07335 - - - - ko00000 - - - Bmp k59_879466_2 568706.BN118_2115 1.79e-42 150.0 COG3146@1|root,COG3146@2|Bacteria,1MU35@1224|Proteobacteria,2VH0Z@28216|Betaproteobacteria,3T2JI@506|Alcaligenaceae 28216|Betaproteobacteria S Peptidogalycan biosysnthesis/recognition - - - ko:K09919 - - - - ko00000 - - - FemAB_like k59_542178_1 1207063.P24_10196 5.33e-85 268.0 COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2TR7S@28211|Alphaproteobacteria,2JQCH@204441|Rhodospirillales 204441|Rhodospirillales I Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus phbC - - ko:K03821 ko00650,map00650 - R04254 RC00004 ko00000,ko00001,ko01000 - - - Abhydrolase_1,PhaC_N k59_156081_1 1121430.JMLG01000004_gene950 2.43e-28 107.0 COG5496@1|root,COG5496@2|Bacteria,1VAZJ@1239|Firmicutes,24MWR@186801|Clostridia,2622Z@186807|Peptococcaceae 186801|Clostridia S THIoesterase - - 3.1.2.29 ko:K18700 - - - - ko00000,ko01000 - - - 4HBT k59_156081_2 1238182.C882_1136 2.03e-40 143.0 COG4094@1|root,COG4094@2|Bacteria,1RDV6@1224|Proteobacteria,2U609@28211|Alphaproteobacteria,2JSHA@204441|Rhodospirillales 204441|Rhodospirillales S NnrU protein - - - - - - - - - - - - NnrU k59_505402_1 395494.Galf_1137 5.64e-99 298.0 COG1932@1|root,COG1932@2|Bacteria,1MUB5@1224|Proteobacteria,2VH5M@28216|Betaproteobacteria,44VKB@713636|Nitrosomonadales 28216|Betaproteobacteria E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine serC - 2.6.1.52 ko:K00831 ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230 M00020,M00124 R04173,R05085 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 k59_462875_1 675635.Psed_3858 6.46e-05 50.4 COG0697@1|root,COG0697@2|Bacteria,2H1HG@201174|Actinobacteria,4E0FR@85010|Pseudonocardiales 201174|Actinobacteria EG metabolite transporter eamA - - ko:K03298,ko:K15268 - - - - ko00000,ko02000 2.A.7.3,2.A.7.3.2 - - EamA k59_250106_1 1336243.JAEA01000010_gene3537 3.28e-80 258.0 COG0028@1|root,COG0028@2|Bacteria,1MX6Q@1224|Proteobacteria,2TS3K@28211|Alphaproteobacteria,1JRKY@119045|Methylobacteriaceae 28211|Alphaproteobacteria EH Belongs to the TPP enzyme family mdlC - 4.1.1.7 ko:K01576 ko00627,ko01120,map00627,map01120 - R01764,R02672 RC00595 ko00000,ko00001,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_931867_1 864069.MicloDRAFT_00034510 1.68e-95 288.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,1JW30@119045|Methylobacteriaceae 28211|Alphaproteobacteria L transposase IS116 IS110 IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_931898_1 265072.Mfla_2481 1.17e-61 196.0 COG4123@1|root,COG4123@2|Bacteria,1QUWW@1224|Proteobacteria,2WHA5@28216|Betaproteobacteria,2KPAD@206350|Nitrosomonadales 206350|Nitrosomonadales S Methionine biosynthesis protein MetW - - - - - - - - - - - - MetW k59_931898_2 977880.RALTA_A0154 2.75e-28 111.0 COG2021@1|root,COG2021@2|Bacteria,1MVJV@1224|Proteobacteria,2VHU9@28216|Betaproteobacteria,1K0H9@119060|Burkholderiaceae 28216|Betaproteobacteria E Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine metXS - 2.3.1.31 ko:K00641 ko00270,ko01100,ko01130,map00270,map01100,map01130 - R01776 RC00004,RC00041 ko00000,ko00001,ko01000 - - - Abhydrolase_1 k59_206890_1 323848.Nmul_A1914 1.4e-101 306.0 COG0101@1|root,COG0101@2|Bacteria,1MUYI@1224|Proteobacteria,2VI0R@28216|Betaproteobacteria,372AM@32003|Nitrosomonadales 28216|Betaproteobacteria J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs truA - 5.4.99.12 ko:K06173 - - - - ko00000,ko01000,ko03016 - - - PseudoU_synth_1 k59_1315391_1 1132855.KB913035_gene789 1.17e-56 189.0 COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,2VI0E@28216|Betaproteobacteria 28216|Betaproteobacteria L PFAM Integrase catalytic - - - - - - - - - - - - HTH_38,rve k59_1230416_1 1121918.ARWE01000001_gene2495 1.21e-17 79.7 2BIZB@1|root,32D7T@2|Bacteria,1Q9TV@1224|Proteobacteria,431GP@68525|delta/epsilon subdivisions,2WWKI@28221|Deltaproteobacteria,43VCZ@69541|Desulfuromonadales 28221|Deltaproteobacteria S Putative prokaryotic signal transducing protein - - - - - - - - - - - - DUF2007 k59_807809_1 1123073.KB899241_gene3120 1.34e-74 233.0 COG0266@1|root,COG0266@2|Bacteria,1MVM5@1224|Proteobacteria,1RP3J@1236|Gammaproteobacteria,1X3ZV@135614|Xanthomonadales 135614|Xanthomonadales L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates fpg - 3.2.2.23,4.2.99.18 ko:K10563 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Fapy_DNA_glyco,H2TH,zf-FPG_IleRS k59_1230443_1 582744.Msip34_0055 5.91e-96 301.0 COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,2VHE8@28216|Betaproteobacteria,2KKN8@206350|Nitrosomonadales 206350|Nitrosomonadales L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG - 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge k59_83747_1 935261.JAGL01000001_gene1713 3.88e-67 225.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,2TRBK@28211|Alphaproteobacteria,43I4X@69277|Phyllobacteriaceae 28211|Alphaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_290105_1 595460.RRSWK_02366 7.58e-77 243.0 COG1524@1|root,COG1524@2|Bacteria,2J563@203682|Planctomycetes 203682|Planctomycetes S Protein of unknown function (DUF1501) - - - - - - - - - - - - DUF1501 k59_1315457_1 153948.NAL212_1210 6.05e-53 187.0 COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,2VIWI@28216|Betaproteobacteria,3728T@32003|Nitrosomonadales 28216|Betaproteobacteria S PFAM Peptidase S45, penicillin amidase - - 3.5.1.11 ko:K01434 ko00311,ko01130,map00311,map01130 - R02170 RC00166,RC00328 ko00000,ko00001,ko01000,ko01002 - - - Penicil_amidase k59_761169_1 488538.SAR116_0352 4.44e-39 150.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,4BPAA@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_338505_1 1131813.AQVT01000001_gene2595 1.08e-22 101.0 COG0845@1|root,COG0845@2|Bacteria,1MUI8@1224|Proteobacteria,2TSP0@28211|Alphaproteobacteria,1JRHG@119045|Methylobacteriaceae 28211|Alphaproteobacteria M type I secretion membrane fusion protein, HlyD family - - - ko:K02022 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD,HlyD_3 k59_841475_1 748247.AZKH_4464 1.03e-96 297.0 COG2203@1|root,COG3576@1|root,COG2203@2|Bacteria,COG3576@2|Bacteria,1PP8V@1224|Proteobacteria,2VKHH@28216|Betaproteobacteria,2KXR2@206389|Rhodocyclales 206389|Rhodocyclales T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - GAF_2,Putative_PNPOx k59_290154_1 572477.Alvin_2015 1.3e-50 175.0 COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,1RN1D@1236|Gammaproteobacteria,1WWDA@135613|Chromatiales 135613|Chromatiales J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA rlmD - 2.1.1.190 ko:K03215 - - - - ko00000,ko01000,ko03009 - - - TRAM,tRNA_U5-meth_tr k59_807909_1 1082933.MEA186_00485 3.51e-70 221.0 COG0451@1|root,COG0451@2|Bacteria,1MUGT@1224|Proteobacteria,2TRF6@28211|Alphaproteobacteria,43J4A@69277|Phyllobacteriaceae 28211|Alphaproteobacteria GM Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction fcl - 1.1.1.271 ko:K02377,ko:K16554 ko00051,ko00520,ko01100,ko05111,map00051,map00520,map01100,map05111 - R05692 RC01014 ko00000,ko00001,ko01000,ko02000 8.A.3.1 - - Epimerase k59_761192_1 999141.GME_16047 1.83e-19 93.2 COG0729@1|root,COG0729@2|Bacteria,1MUKM@1224|Proteobacteria,1RNQ3@1236|Gammaproteobacteria,1XHG0@135619|Oceanospirillales 135619|Oceanospirillales M COG0729 Outer membrane protein - - - ko:K07278 - - - - ko00000,ko02000 1.B.33.2.4 - - Bac_surface_Ag,POTRA,POTRA_TamA_1 k59_338512_1 348824.LPU83_pLPU83a_0068 5.33e-92 272.0 COG3335@1|root,COG3335@2|Bacteria,1RB1C@1224|Proteobacteria,2U367@28211|Alphaproteobacteria,4BC4T@82115|Rhizobiaceae 28211|Alphaproteobacteria L protein y4pE y4sA - - - - - - - - - - - - DDE_3 k59_463111_1 640512.BC1003_0426 3.16e-50 167.0 COG2353@1|root,COG2353@2|Bacteria,1R9XD@1224|Proteobacteria,2WFNB@28216|Betaproteobacteria,1KFZQ@119060|Burkholderiaceae 28216|Betaproteobacteria S Belongs to the UPF0312 family - - - - - - - - - - - - YceI k59_1187710_1 264402.Cagra.0179s0030.1.p 7.77e-10 62.0 COG1073@1|root,KOG4391@2759|Eukaryota,37KB9@33090|Viridiplantae,3G9K6@35493|Streptophyta,3HRH1@3699|Brassicales 35493|Streptophyta S Dienelactone hydrolase family - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005886,GO:0007275,GO:0008150,GO:0012505,GO:0016020,GO:0019866,GO:0022622,GO:0031090,GO:0031967,GO:0031975,GO:0032501,GO:0032502,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0048364,GO:0048731,GO:0048856,GO:0071944,GO:0099402 - ko:K06889 - - - - ko00000 - - - Hydrolase_4,Peptidase_S9 k59_1187710_2 1532557.JL37_22715 5.34e-26 105.0 COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,2VHS3@28216|Betaproteobacteria,3T1EM@506|Alcaligenaceae 28216|Betaproteobacteria H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction thiC - 4.1.99.17 ko:K03147 ko00730,ko01100,map00730,map01100 M00127 R03472 RC03251,RC03252 ko00000,ko00001,ko00002,ko01000 - - - ThiC-associated,ThiC_Rad_SAM k59_162093_1 261292.Nit79A3_2151 2.28e-67 210.0 COG0558@1|root,COG0558@2|Bacteria,1RCZ7@1224|Proteobacteria,2VQI2@28216|Betaproteobacteria,372TT@32003|Nitrosomonadales 28216|Betaproteobacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pgsA - 2.7.8.41,2.7.8.5 ko:K00995,ko:K08744 ko00564,ko01100,map00564,map01100 - R01801,R02030 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf k59_162093_2 748280.NH8B_3185 2.36e-99 310.0 COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,2VIM4@28216|Betaproteobacteria,2KPQ4@206351|Neisseriales 206351|Neisseriales L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC - - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH,HHH_2,HHH_5,UVR,UvrC_HhH_N k59_338533_1 1125863.JAFN01000001_gene3457 2.91e-14 76.3 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,43BSB@68525|delta/epsilon subdivisions,2X735@28221|Deltaproteobacteria 28221|Deltaproteobacteria T histidine kinase A domain protein - - - - - - - - - - - - HATPase_c,HisKA,SBP_bac_3 k59_381843_1 1280950.HJO_13426 2.18e-05 47.0 2AMGI@1|root,31CC2@2|Bacteria,1Q8DB@1224|Proteobacteria,2V78T@28211|Alphaproteobacteria,43ZCU@69657|Hyphomonadaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_932143_1 68219.JNXI01000017_gene7353 2.72e-10 64.3 COG2175@1|root,COG2175@2|Bacteria,2GNUC@201174|Actinobacteria 201174|Actinobacteria Q taurine catabolism dioxygenase - - - ko:K22303 - - - - ko00000,ko01000 - - - TauD k59_932143_2 570952.ATVH01000016_gene2499 1.46e-14 71.6 COG3820@1|root,COG3820@2|Bacteria,1MVR2@1224|Proteobacteria,2TT8Z@28211|Alphaproteobacteria,2JRSY@204441|Rhodospirillales 204441|Rhodospirillales S protein conserved in bacteria - - - ko:K09987 - - - - ko00000 - - - DUF1013 k59_1140073_1 1002340.AFCF01000043_gene2045 1.35e-48 155.0 COG2963@1|root,COG2963@2|Bacteria,1RGZ5@1224|Proteobacteria,2UAIS@28211|Alphaproteobacteria 28211|Alphaproteobacteria L COG2801 Transposase and inactivated derivatives - - - - - - - - - - - - HTH_Tnp_1 k59_1140073_2 388739.RSK20926_15481 1.02e-56 183.0 COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,2P3AF@2433|Roseobacter 28211|Alphaproteobacteria L COG2801 Transposase and inactivated derivatives - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve,rve_3 k59_1230643_1 344747.PM8797T_23039 6.11e-64 210.0 COG0166@1|root,COG0166@2|Bacteria,2IXRA@203682|Planctomycetes 203682|Planctomycetes G Belongs to the GPI family pgi - 5.3.1.9 ko:K01810 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114 R02739,R02740,R03321 RC00376,RC00563 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGI k59_1230643_2 314230.DSM3645_29316 2.04e-51 171.0 COG3588@1|root,COG3588@2|Bacteria 2|Bacteria G fructose-bisphosphate aldolase fda - 4.1.2.13 ko:K01623 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000,ko03036,ko04131,ko04147 - - - Glycolytic k59_207148_1 76114.ebA1312 1.48e-28 110.0 COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,2VI5T@28216|Betaproteobacteria,2KUIX@206389|Rhodocyclales 206389|Rhodocyclales Q COG0767 ABC-type transport system involved in resistance to organic solvents, permease component - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE k59_207148_2 640081.Dsui_1398 2.84e-97 290.0 COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,2VJIA@28216|Betaproteobacteria,2KUXY@206389|Rhodocyclales 206389|Rhodocyclales Q ABC-type transport system involved in resistance to organic solvents, ATPase component - - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran k59_250440_1 1167006.UWK_00280 9.89e-42 145.0 COG2095@1|root,COG2095@2|Bacteria,1REDU@1224|Proteobacteria 1224|Proteobacteria U MarC family integral membrane protein - - - - - - - - - - - - MarC k59_338686_1 1469245.JFBG01000014_gene2027 2.63e-72 232.0 COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,1RMQB@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Tripartite tricarboxylate transporter TctA - - - ko:K07793 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.80.1 - - TctA k59_338686_2 571166.KI421509_gene1729 5.94e-31 114.0 2C1YH@1|root,32R9E@2|Bacteria,1RF0Z@1224|Proteobacteria,2UB3H@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Tripartite tricarboxylate transporter TctB family - - - - - - - - - - - - TctB k59_381960_1 59538.XP_005976553.1 5.29e-30 116.0 COG1171@1|root,KOG1250@2759|Eukaryota,38BCJ@33154|Opisthokonta,3BCRY@33208|Metazoa,3CU6K@33213|Bilateria,480D0@7711|Chordata,48ZR5@7742|Vertebrata,3JBFX@40674|Mammalia,4IZP0@91561|Cetartiodactyla 33208|Metazoa E dehydratase - - 4.3.1.17,4.3.1.19 ko:K17989 ko00260,ko00270,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00590,R00996 RC00331,RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP,RRM_1 k59_1187908_1 1479237.JMLY01000001_gene818 6.24e-20 92.4 COG2206@1|root,COG2206@2|Bacteria,1MW7F@1224|Proteobacteria,1RPEZ@1236|Gammaproteobacteria,465ZX@72275|Alteromonadaceae 1236|Gammaproteobacteria T COG2206 HD-GYP domain - - - - - - - - - - - - DUF3391,HD,HD_5 k59_382019_1 248742.XP_005652202.1 9.64e-23 101.0 COG1028@1|root,COG4122@1|root,KOG0725@2759|Eukaryota,KOG1663@2759|Eukaryota,37ZA0@33090|Viridiplantae 33090|Viridiplantae Q KR domain - - - - - - - - - - - - adh_short_C2 k59_84057_1 670307.HYPDE_35973 3.02e-161 484.0 COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,2TQSP@28211|Alphaproteobacteria,3N6CN@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_463369_1 867903.ThesuDRAFT_01746 4.71e-20 90.9 COG4221@1|root,COG4221@2|Bacteria,1V8DC@1239|Firmicutes,25GIM@186801|Clostridia 186801|Clostridia S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_884898_1 1188252.AJYK01000022_gene1407 3.02e-13 75.1 COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,1RMFJ@1236|Gammaproteobacteria,1XT6V@135623|Vibrionales 135623|Vibrionales H Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB btuB GO:0003674,GO:0005215 - ko:K16092 - - - - ko00000,ko02000 1.B.14.3 - - Plug,TonB_dep_Rec k59_884898_2 743721.Psesu_0598 6.9e-44 147.0 COG2096@1|root,COG2096@2|Bacteria,1RDUF@1224|Proteobacteria,1S40D@1236|Gammaproteobacteria,1X50D@135614|Xanthomonadales 135614|Xanthomonadales S adenosyltransferase - - 2.5.1.17 ko:K00798 ko00860,ko01100,map00860,map01100 M00122 R01492,R05220,R07268 RC00533 ko00000,ko00001,ko00002,ko01000 - - - Cob_adeno_trans k59_1188007_1 640512.BC1003_0664 3.6e-78 246.0 COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2VZNG@28216|Betaproteobacteria,1K6IW@119060|Burkholderiaceae 28216|Betaproteobacteria L similarity to GP 3192745 - - - - - - - - - - - - DDE_Tnp_1_6,DUF772 k59_841753_1 748247.AZKH_p0501 1.1e-117 361.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,2VIAU@28216|Betaproteobacteria,2KUM5@206389|Rhodocyclales 28216|Betaproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner - - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_250643_1 398767.Glov_3716 4.48e-57 193.0 COG4584@1|root,COG4584@2|Bacteria,1MU2G@1224|Proteobacteria,42N2X@68525|delta/epsilon subdivisions,2X7GJ@28221|Deltaproteobacteria 28221|Deltaproteobacteria L Sigma-70, region 4 - - - - - - - - - - - - rve k59_1230884_1 1100720.ALKN01000040_gene2207 1.21e-56 186.0 COG2242@1|root,COG2242@2|Bacteria,1R0I9@1224|Proteobacteria,2VRVM@28216|Betaproteobacteria 28216|Betaproteobacteria M Histone methylation protein DOT1 - - - - - - - - - - - - Methyltransf_31 k59_250656_1 420662.Mpe_A1928 5.86e-23 91.3 COG3651@1|root,COG3651@2|Bacteria,1RH68@1224|Proteobacteria,2VSN3@28216|Betaproteobacteria,1KM4X@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2237) - - - ko:K09966 - - - - ko00000 - - - DUF2237 k59_250656_2 1255043.TVNIR_3268 1.71e-27 111.0 COG0281@1|root,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,1RQ11@1236|Gammaproteobacteria,1WX9G@135613|Chromatiales 135613|Chromatiales C PFAM Malic enzyme, NAD binding domain - - 1.1.1.40 ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200 M00169,M00172 R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - - Malic_M,malic k59_162472_1 305700.B447_12774 5.12e-89 269.0 COG0842@1|root,COG0842@2|Bacteria,1MUH1@1224|Proteobacteria,2VH42@28216|Betaproteobacteria,2KUGF@206389|Rhodocyclales 206389|Rhodocyclales V Transport permease protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane k59_207441_1 305700.B447_17276 7.41e-35 126.0 COG3019@1|root,COG3019@2|Bacteria,1MZ9V@1224|Proteobacteria,2VSDN@28216|Betaproteobacteria,2KWKP@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function, DUF - - - - - - - - - - - - DUF411 k59_932480_1 911045.PSE_3238 1.03e-25 102.0 COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,2TTIX@28211|Alphaproteobacteria 28211|Alphaproteobacteria U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides tatC - - ko:K03118 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - TatC k59_932480_2 1088868.CIN_19060 6.07e-10 62.0 COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,2TR4T@28211|Alphaproteobacteria,2JQAP@204441|Rhodospirillales 204441|Rhodospirillales J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Seryl_tRNA_N,tRNA-synt_2b k59_761621_1 1089552.KI911559_gene2017 1.65e-41 138.0 COG2963@1|root,COG2963@2|Bacteria,1RGZ5@1224|Proteobacteria,2UAIS@28211|Alphaproteobacteria,2JT7W@204441|Rhodospirillales 204441|Rhodospirillales L Transposase - - - - - - - - - - - - HTH_Tnp_1 k59_463555_1 1123399.AQVE01000001_gene691 2.54e-33 127.0 COG0842@1|root,COG0842@2|Bacteria,1QTBE@1224|Proteobacteria,1RNG9@1236|Gammaproteobacteria,461U3@72273|Thiotrichales 72273|Thiotrichales V ABC-2 family transporter protein - - - - - - - - - - - - ABC2_membrane k59_463555_2 765912.Thimo_3125 0.000211 43.5 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria,1WWG5@135613|Chromatiales 135613|Chromatiales V pfam abc - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_39470_1 1538295.JY96_01985 4.49e-08 55.5 COG0307@1|root,COG0307@2|Bacteria,1MUMB@1224|Proteobacteria,2VIU0@28216|Betaproteobacteria,1KJ5C@119065|unclassified Burkholderiales 28216|Betaproteobacteria H Riboflavin synthase ribE - 2.5.1.9 ko:K00793 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00066 RC00958,RC00960 ko00000,ko00001,ko00002,ko01000 - - - Lum_binding k59_39470_2 1229205.BUPH_03290 1.95e-36 135.0 COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,2VI9P@28216|Betaproteobacteria,1JZMJ@119060|Burkholderiaceae 28216|Betaproteobacteria H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate ribD - 1.1.1.193,3.5.4.26 ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 - - - RibD_C,dCMP_cyt_deam_1 k59_761631_1 272560.BPSL2104 6.98e-107 336.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,2VHXF@28216|Betaproteobacteria,1K23B@119060|Burkholderiaceae 28216|Betaproteobacteria M penicillin-binding protein 1A mrcA - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - PCB_OB,Transgly,Transpeptidase k59_506133_1 1502851.FG93_04768 2.61e-74 234.0 COG0473@1|root,COG0473@2|Bacteria,1QU2H@1224|Proteobacteria,2VFXG@28211|Alphaproteobacteria,3JRN8@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria CE Isocitrate/isopropylmalate dehydrogenase - GO:0006082,GO:0006575,GO:0006732,GO:0006793,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016053,GO:0019297,GO:0019298,GO:0019752,GO:0032787,GO:0042398,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576 1.1.1.42,1.1.1.83,1.1.1.85,1.1.1.93,4.1.1.73 ko:K00031,ko:K00052,ko:K07246 ko00020,ko00290,ko00480,ko00630,ko00650,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00290,map00480,map00630,map00650,map00660,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00432,M00535,M00740 R00215,R00267,R00268,R00994,R01751,R01899,R02545,R04426,R06180,R10052 RC00001,RC00084,RC00105,RC00114,RC00417,RC00594,RC00626,RC02801,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_421545_1 264198.Reut_B4652 3.92e-97 299.0 COG1894@1|root,COG1905@1|root,COG1894@2|Bacteria,COG1905@2|Bacteria,1MV8F@1224|Proteobacteria,2VIMM@28216|Betaproteobacteria,1K5P1@119060|Burkholderiaceae 28216|Betaproteobacteria C formate dehydrogenase fdwB - 1.17.1.9 ko:K00122 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - 2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB k59_382259_2 667014.Thein_1099 2.7e-20 89.4 COG2930@1|root,COG2930@2|Bacteria,2GI8Q@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria S Las17-binding protein actin regulator - - - - - - - - - - - - Ysc84 k59_1188207_1 1532558.JL39_15710 4.72e-15 80.5 COG1132@1|root,COG4988@1|root,COG1132@2|Bacteria,COG4988@2|Bacteria,1MWTY@1224|Proteobacteria,2TRSY@28211|Alphaproteobacteria,4BAKA@82115|Rhizobiaceae 28211|Alphaproteobacteria V ABC transporter - - - ko:K02021 - - - - ko00000,ko02000 3.A.1.106,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21 - - ABC_membrane,ABC_tran,cNMP_binding k59_339010_1 98439.AJLL01000052_gene3654 1.05e-24 110.0 COG0709@1|root,COG1252@1|root,COG0709@2|Bacteria,COG1252@2|Bacteria,1G21Z@1117|Cyanobacteria,1JGXG@1189|Stigonemataceae 1117|Cyanobacteria CE Pyridine nucleotide-disulphide oxidoreductase selD - 2.7.9.3 ko:K01008 ko00450,ko01100,map00450,map01100 - R03595 RC00002,RC02878 ko00000,ko00001,ko01000,ko03016 - - - AIRS,AIRS_C,Pyr_redox_2 k59_506180_1 105559.Nwat_0103 7.24e-58 195.0 COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,1T1MS@1236|Gammaproteobacteria,1WX38@135613|Chromatiales 135613|Chromatiales P CBS domain - - - ko:K03699 - - - - ko00000,ko02042 - - - CBS,CorC_HlyC,DUF21 k59_1188247_1 1434929.X946_3721 5.17e-21 90.1 COG5490@1|root,COG5490@2|Bacteria,1R4SV@1224|Proteobacteria,2VQP2@28216|Betaproteobacteria,1JZMD@119060|Burkholderiaceae 28216|Betaproteobacteria S TIGRFAM phasin family protein phaP2 - - - - - - - - - - - Phasin_2 k59_382303_2 62928.azo3226 1.17e-18 92.0 COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,2VHI9@28216|Betaproteobacteria,2KUN3@206389|Rhodocyclales 206389|Rhodocyclales L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,DnaG_DnaB_bind,Toprim_4,Toprim_N,zf-CHC2 k59_1273583_1 888743.HMPREF9141_1258 1.65e-12 67.8 COG0205@1|root,COG0205@2|Bacteria,4NF8F@976|Bacteroidetes,2FMPI@200643|Bacteroidia 976|Bacteroidetes F Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis pfkA - 2.7.1.11 ko:K00850 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230 M00001,M00345 R00756,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko01009,ko03019 - - - PFK k59_1273583_2 521045.Kole_0848 2.37e-87 275.0 COG1322@1|root,COG1322@2|Bacteria,2GDWC@200918|Thermotogae 200918|Thermotogae S RmuC family - - - ko:K09760 - - - - ko00000 - - - RmuC k59_761741_1 497321.C664_10782 5.2e-31 120.0 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2VH5A@28216|Betaproteobacteria,2KV7J@206389|Rhodocyclales 206389|Rhodocyclales C glycolate oxidase subunit GlcD - - - - - - - - - - - - FAD-oxidase_C,FAD_binding_4 k59_761741_2 1380394.JADL01000001_gene2567 1.31e-75 232.0 COG0028@1|root,COG0028@2|Bacteria,1R6QP@1224|Proteobacteria,2TXAJ@28211|Alphaproteobacteria,2JWX2@204441|Rhodospirillales 204441|Rhodospirillales EH Thiamine pyrophosphate enzyme, C-terminal TPP binding domain - - - - - - - - - - - - TPP_enzyme_C k59_207594_1 439235.Dalk_1867 1.7e-06 55.5 COG0784@1|root,COG2202@1|root,COG4191@1|root,COG4936@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG4191@2|Bacteria,COG4936@2|Bacteria,1RCM9@1224|Proteobacteria,42M1R@68525|delta/epsilon subdivisions,2X734@28221|Deltaproteobacteria,2MIC0@213118|Desulfobacterales 28221|Deltaproteobacteria T histidine kinase A domain protein - - - - - - - - - - - - GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg k59_1140466_1 471853.Bcav_2961 1.02e-15 80.9 2DG3P@1|root,2ZUBI@2|Bacteria,2IJPQ@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_761750_2 234267.Acid_3233 0.000573 42.7 COG0577@1|root,COG0577@2|Bacteria,3Y6QA@57723|Acidobacteria 57723|Acidobacteria V MacB-like periplasmic core domain - - - - - - - - - - - - FtsX,MacB_PCD k59_808623_1 985054.JQEZ01000001_gene2215 5.67e-118 364.0 COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,2TTPX@28211|Alphaproteobacteria,4NANY@97050|Ruegeria 28211|Alphaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family fdhF - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_885311_1 880072.Desac_0860 2.76e-74 240.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,42M81@68525|delta/epsilon subdivisions,2WJXY@28221|Deltaproteobacteria,2MQTE@213462|Syntrophobacterales 28221|Deltaproteobacteria C TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein sdhA - 1.3.5.1,1.3.5.4 ko:K00239,ko:K00244 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,ko05134,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020,map05134 M00009,M00011,M00149,M00150,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_932844_1 448385.sce1060 7.59e-73 235.0 COG3396@1|root,COG3396@2|Bacteria,1MXUK@1224|Proteobacteria,437U1@68525|delta/epsilon subdivisions,2X33K@28221|Deltaproteobacteria,2YU2K@29|Myxococcales 28221|Deltaproteobacteria S benzoyl-CoA oxygenase - - 1.14.13.208 ko:K15512 ko00362,map00362 - R09555 RC01739 ko00000,ko00001,ko01000 - - - - k59_120647_1 1286106.MPL1_04342 3.79e-58 192.0 COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,1RMNB@1236|Gammaproteobacteria,45ZRM@72273|Thiotrichales 72273|Thiotrichales I acetyl-CoA carboxylase, biotin carboxylase accC - 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_120647_2 1168065.DOK_01249 1.09e-13 71.2 COG2264@1|root,COG2264@2|Bacteria,1MUPC@1224|Proteobacteria,1RNAR@1236|Gammaproteobacteria,1J4VE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Ribosomal protein L11 methyltransferase prmA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006480,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016278,GO:0016279,GO:0016740,GO:0016741,GO:0018011,GO:0018012,GO:0018022,GO:0018023,GO:0018193,GO:0018194,GO:0018205,GO:0019538,GO:0031365,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564 - ko:K02687 - - - - ko00000,ko01000,ko03009 - - - PrmA k59_1231342_1 331869.BAL199_06709 1.58e-100 299.0 COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,2TS3N@28211|Alphaproteobacteria,4BQU8@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria O Peptidase family M48 htpX - - ko:K03799 - M00743 - - ko00000,ko00002,ko01000,ko01002 - - - Peptidase_M48 k59_885389_1 296591.Bpro_1406 2.12e-91 294.0 COG0457@1|root,COG3629@1|root,COG3899@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2VPH8@28216|Betaproteobacteria,4AF3Y@80864|Comamonadaceae 28216|Betaproteobacteria K AAA ATPase domain - - - - - - - - - - - - AAA_16,BTAD k59_421884_1 1232410.KI421425_gene1553 1.44e-51 183.0 COG4932@1|root,COG4932@2|Bacteria,1QZFW@1224|Proteobacteria 1224|Proteobacteria M domain protein - - - - - - - - - - - - DUF11,SdrD_B k59_1363184_1 1298867.AUES01000051_gene4511 1.1e-11 71.6 COG0771@1|root,COG2931@1|root,COG4625@1|root,COG0771@2|Bacteria,COG2931@2|Bacteria,COG4625@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,3K2H3@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria Q Haemolysin-type calcium-binding repeat (2 copies) - - - - - - - - - - - - FG-GAP,HemolysinCabind k59_885412_1 330214.NIDE3764 3.51e-46 158.0 28PNA@1|root,2ZCB3@2|Bacteria 2|Bacteria S Transglycosylase SLT domain - - - - - - - - - - - - SLT k59_463975_1 1379281.AVAG01000020_gene1062 4.58e-26 108.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIPP@28221|Deltaproteobacteria,2M915@213115|Desulfovibrionales 28221|Deltaproteobacteria NU PFAM Type II secretion system protein E gspE - - ko:K02454 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSE,T2SSE_N k59_463975_2 314345.SPV1_04393 7.19e-21 94.4 COG2206@1|root,COG3437@1|root,COG2206@2|Bacteria,COG3437@2|Bacteria,1MV37@1224|Proteobacteria 1224|Proteobacteria T domain protein - - - - - - - - - - - - GAF,HD,HD_5 k59_207902_1 883126.HMPREF9710_02326 5.43e-55 195.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VJMN@28216|Betaproteobacteria,476HZ@75682|Oxalobacteraceae 28216|Betaproteobacteria T 7TM diverse intracellular signalling - - - - - - - - - - - - 7TMR-DISM_7TM,EAL,GGDEF,HAMP,PAS,PAS_4,PAS_8,PAS_9,dCache_3 k59_885422_1 519989.ECTPHS_01879 9.14e-84 263.0 COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,1RN88@1236|Gammaproteobacteria,1WW6B@135613|Chromatiales 135613|Chromatiales M Belongs to the MurCDEF family murC - 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_719615_1 1235457.C404_08355 1.66e-83 261.0 COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,2VINP@28216|Betaproteobacteria,1K1SF@119060|Burkholderiaceae 28216|Betaproteobacteria E Belongs to the aspartokinase family lysC GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT,ACT_7 k59_1017592_1 288000.BBta_1644 5.76e-72 234.0 COG0028@1|root,COG0028@2|Bacteria,1MX6Q@1224|Proteobacteria,2TS3K@28211|Alphaproteobacteria,3JUFH@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria EH Belongs to the TPP enzyme family MA20_06195 - 4.1.1.7 ko:K01576 ko00627,ko01120,map00627,map01120 - R01764,R02672 RC00595 ko00000,ko00001,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_162983_1 1303518.CCALI_00440 5.12e-69 234.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria 2|Bacteria E methionine synthase metH GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - iECO103_1326.ECO103_4764,iECUMN_1333.ECUMN_4545 B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_933016_2 1298867.AUES01000026_gene3022 5.78e-117 341.0 COG0410@1|root,COG0410@2|Bacteria,1NKE2@1224|Proteobacteria,2U14V@28211|Alphaproteobacteria,3JRRS@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E ATPases associated with a variety of cellular activities - - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran k59_1140789_1 1157708.KB907452_gene4020 3.05e-09 57.8 COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,2VHPK@28216|Betaproteobacteria,4A9QW@80864|Comamonadaceae 28216|Betaproteobacteria M PFAM Lytic transglycosylase catalytic slt - - ko:K08309 - - - - ko00000,ko01000,ko01011 - GH23 - SLT,SLT_L k59_1140789_2 1348657.M622_00655 1.69e-42 149.0 COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,2VIBZ@28216|Betaproteobacteria,2KUXF@206389|Rhodocyclales 206389|Rhodocyclales GM epimerase dehydratase - - 1.6.5.3,1.6.99.3 ko:K00329,ko:K00356 ko00190,map00190 - R11945 RC00061 ko00000,ko00001,ko01000 - - - Epimerase,NAD_binding_10 k59_207982_1 1254432.SCE1572_00935 2.33e-85 268.0 COG0624@1|root,COG0624@2|Bacteria,1MW20@1224|Proteobacteria,437V8@68525|delta/epsilon subdivisions,2X34Q@28221|Deltaproteobacteria,2YU9A@29|Myxococcales 28221|Deltaproteobacteria E Peptidase dimerisation domain dapE1 - - - - - - - - - - - M20_dimer,Peptidase_M20 k59_549158_1 1163617.SCD_n02623 2.65e-89 271.0 COG1947@1|root,COG1947@2|Bacteria,1MVU3@1224|Proteobacteria,2VHK3@28216|Betaproteobacteria 28216|Betaproteobacteria F Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol ispE - 2.7.1.148 ko:K00919 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05634 RC00002,RC01439 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N k59_808912_2 1218074.BAXZ01000006_gene1651 8.77e-05 47.4 COG1024@1|root,COG1024@2|Bacteria,1R6CV@1224|Proteobacteria,2VQSU@28216|Betaproteobacteria,1JZZP@119060|Burkholderiaceae 28216|Betaproteobacteria I Belongs to the enoyl-CoA hydratase isomerase family - - - - - - - - - - - - ECH_1 k59_1140834_1 1123487.KB892864_gene2109 4.57e-37 147.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria 28216|Betaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - EAL,GAF_2,GGDEF,PAS_4,Response_reg k59_1363359_1 203124.Tery_3048 1.84e-13 77.0 COG4932@1|root,COG4932@2|Bacteria,1G0MJ@1117|Cyanobacteria,1H9HP@1150|Oscillatoriales 1117|Cyanobacteria M PFAM Collagen-binding surface protein Cna-like, B-type domain - - - - - - - - - - - - SdrD_B,Trypsin k59_762176_1 1226994.AMZB01000138_gene5750 8.62e-12 70.5 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,1RPV3@1236|Gammaproteobacteria,1YFM9@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria NU Neisseria PilC beta-propeller domain pilY1 - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC,VWA_2 k59_762183_1 1089552.KI911559_gene1278 1.14e-66 209.0 COG2128@1|root,COG2128@2|Bacteria,1RD1K@1224|Proteobacteria,2U6ZZ@28211|Alphaproteobacteria,2JU9D@204441|Rhodospirillales 204441|Rhodospirillales S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - - - - - - - - - - CMD k59_677756_1 595537.Varpa_3009 3.08e-70 239.0 COG1640@1|root,COG3280@1|root,COG1640@2|Bacteria,COG3280@2|Bacteria,1QTVJ@1224|Proteobacteria,2WGPV@28216|Betaproteobacteria,4AD3R@80864|Comamonadaceae 28216|Betaproteobacteria G SMART alpha amylase catalytic sub domain treY - 2.4.1.25,5.4.99.15 ko:K00705,ko:K06044 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R01824,R05196,R09995 RC00049 ko00000,ko00001,ko00002,ko01000 - GH13,GH77 - Alpha-amylase,Glyco_hydro_77 k59_885569_1 1088721.NSU_3456 1.42e-43 152.0 COG0329@1|root,COG0329@2|Bacteria 2|Bacteria E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) - - 4.1.2.45 ko:K14585 ko00626,ko01100,ko01120,ko01220,map00626,map01100,map01120,map01220 M00534 R05136 RC00924,RC00936 br01602,ko00000,ko00001,ko00002,ko01000 - - - DHDPS k59_339551_2 266264.Rmet_2136 2.18e-72 230.0 COG3228@1|root,COG3228@2|Bacteria,1RAHF@1224|Proteobacteria,2VJTJ@28216|Betaproteobacteria,1KH4K@119060|Burkholderiaceae 28216|Betaproteobacteria S Belongs to the MtfA family mtfA - - ko:K09933 - - - - ko00000,ko01002 - - - Peptidase_M90 k59_339551_3 1415780.JPOG01000001_gene120 6.53e-11 61.2 COG0655@1|root,COG0655@2|Bacteria,1RAP5@1224|Proteobacteria,1S3B1@1236|Gammaproteobacteria,1X762@135614|Xanthomonadales 135614|Xanthomonadales S NADPH-dependent FMN reductase - - - - - - - - - - - - FMN_red k59_549236_1 489825.LYNGBM3L_67650 1.68e-43 161.0 COG0457@1|root,COG1216@1|root,COG3914@1|root,COG0457@2|Bacteria,COG1216@2|Bacteria,COG3914@2|Bacteria,1G0YS@1117|Cyanobacteria,1H82I@1150|Oscillatoriales 1117|Cyanobacteria O O-linked N-acetylglucosamine transferase SPINDLY family - - - - - - - - - - - - Glyco_transf_41,Sulfotransfer_2,TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8 k59_382807_1 1379698.RBG1_1C00001G1661 3.55e-80 252.0 COG1239@1|root,COG1239@2|Bacteria,2NQQG@2323|unclassified Bacteria 2|Bacteria H Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX chlI - 6.6.1.1 ko:K03405 ko00860,ko01100,ko01110,map00860,map01100,map01110 - R03877 RC01012 ko00000,ko00001,ko01000 - - iNJ661.Rv0958 Mg_chelatase,Sigma54_activat k59_422124_1 394.NGR_c35870 1.4e-73 236.0 COG1861@1|root,COG1861@2|Bacteria,1QU5J@1224|Proteobacteria,2U0ZH@28211|Alphaproteobacteria,4BJ1H@82115|Rhizobiaceae 28211|Alphaproteobacteria L Transposase DDE domain group 1 - - - - - - - - - - - - DDE_Tnp_1_4 k59_291284_1 1279009.ADICEAN_01017 1.89e-100 319.0 COG4447@1|root,COG4447@2|Bacteria,4NESU@976|Bacteroidetes,47M5A@768503|Cytophagia 976|Bacteroidetes S Sortilin, neurotensin receptor 3, - - - - - - - - - - - - Sortilin-Vps10 k59_251441_1 1031711.RSPO_c00697 1.02e-25 105.0 COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,2VJ3W@28216|Betaproteobacteria,1K36E@119060|Burkholderiaceae 28216|Betaproteobacteria U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components ffh - 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB k59_251441_2 404589.Anae109_1864 5.97e-62 200.0 COG0598@1|root,COG0598@2|Bacteria,1MX09@1224|Proteobacteria,42NS9@68525|delta/epsilon subdivisions,2WJMJ@28221|Deltaproteobacteria,2YV6M@29|Myxococcales 28221|Deltaproteobacteria P Mediates influx of magnesium ions corA - - ko:K03284,ko:K16074 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3,1.A.35.4 - - CorA k59_1316656_1 1304878.AUGD01000002_gene2056 4.46e-58 201.0 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria,3JQVN@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain MA20_27485 - 1.2.5.3 ko:K03520 - - R11168 RC02800 ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_1316656_2 765914.ThisiDRAFT_1875 1.16e-13 69.7 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPWS@1236|Gammaproteobacteria,1WWTW@135613|Chromatiales 135613|Chromatiales S ABC transporter - - - - - - - - - - - - ABC_tran,ABC_tran_Xtn k59_464259_1 1121013.P873_00160 1.76e-06 51.2 COG4784@1|root,COG4784@2|Bacteria,1QXTD@1224|Proteobacteria,1S66C@1236|Gammaproteobacteria,1X6UJ@135614|Xanthomonadales 135614|Xanthomonadales S Peptidase family M48 - - - - - - - - - - - - Peptidase_M48 k59_40243_1 946483.Cenrod_1830 1.98e-61 192.0 COG0335@1|root,COG0335@2|Bacteria,1RH3A@1224|Proteobacteria,2VR2S@28216|Betaproteobacteria,4ADW5@80864|Comamonadaceae 28216|Betaproteobacteria J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site rplS - - ko:K02884 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L19 k59_40243_2 748247.AZKH_3485 3.54e-79 243.0 COG0336@1|root,COG0336@2|Bacteria,1MUN1@1224|Proteobacteria,2VHPY@28216|Betaproteobacteria,2KUD3@206389|Rhodocyclales 206389|Rhodocyclales J Belongs to the RNA methyltransferase TrmD family trmD - 2.1.1.228 ko:K00554 - - R00597 RC00003,RC00334 ko00000,ko01000,ko03016 - - - tRNA_m1G_MT k59_343498_2 426117.M446_6188 2.29e-10 60.1 COG0560@1|root,COG0560@2|Bacteria,1MWA3@1224|Proteobacteria,2TSEU@28211|Alphaproteobacteria,1JR10@119045|Methylobacteriaceae 28211|Alphaproteobacteria E PFAM Haloacid dehalogenase domain protein hydrolase serB - 3.1.3.3 ko:K01079 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R00582 RC00017 ko00000,ko00001,ko00002,ko01000,ko01009 - - - HAD k59_599764_1 396588.Tgr7_2196 1.05e-64 211.0 COG5557@1|root,COG5557@2|Bacteria,1MXP7@1224|Proteobacteria,1RS7Z@1236|Gammaproteobacteria,1WX2A@135613|Chromatiales 135613|Chromatiales C PFAM Polysulphide reductase, NrfD - - - ko:K00185 - - - - ko00000 5.A.3 - - NrfD k59_1323895_1 1366050.N234_30000 0.000998 41.2 COG4706@1|root,COG4706@2|Bacteria,1RIH4@1224|Proteobacteria,2VT0K@28216|Betaproteobacteria,1K7TQ@119060|Burkholderiaceae 28216|Betaproteobacteria I dehydratase - - - - - - - - - - - - - k59_1323895_2 296591.Bpro_3307 2.62e-107 316.0 COG1028@1|root,COG1028@2|Bacteria,1MUPY@1224|Proteobacteria,2VK19@28216|Betaproteobacteria,4AACV@80864|Comamonadaceae 28216|Betaproteobacteria IQ KR domain fabG2 - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short,adh_short_C2 k59_1323895_3 748247.AZKH_1772 1.55e-74 229.0 COG0463@1|root,COG0463@2|Bacteria,1QTWH@1224|Proteobacteria,2VKU3@28216|Betaproteobacteria,2KUT6@206389|Rhodocyclales 206389|Rhodocyclales M Glycosyltransferase like family 2 - - - ko:K00786 - - - - ko00000,ko01000 - - - Glycos_transf_2 k59_1195884_1 522306.CAP2UW1_1923 5.73e-76 238.0 COG0604@1|root,COG0604@2|Bacteria,1MV3W@1224|Proteobacteria,2VINX@28216|Betaproteobacteria 28216|Betaproteobacteria C alcohol dehydrogenase - - 1.1.1.1 ko:K00001 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_1195887_2 1163617.SCD_n00907 1.39e-50 172.0 COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,2VH7Z@28216|Betaproteobacteria 28216|Betaproteobacteria H Catalyzes the ferrous insertion into protoporphyrin IX hemH - 4.99.1.1,4.99.1.9 ko:K01772 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R00310,R11329 RC01012 ko00000,ko00001,ko00002,ko01000 - - - Ferrochelatase k59_769817_1 1384056.N787_00810 2.27e-66 215.0 COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,1RQVT@1236|Gammaproteobacteria 1236|Gammaproteobacteria L COG3666 Transposase and inactivated derivatives - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_428689_1 1183438.GKIL_2059 1.2e-69 221.0 COG1171@1|root,COG1171@2|Bacteria,1G22X@1117|Cyanobacteria 1117|Cyanobacteria E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA - - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_897518_1 1469245.JFBG01000027_gene1495 1.33e-181 522.0 COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,1RN0R@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family actP - - ko:K14393 - - - - ko00000,ko02000 2.A.21.7 - - SSF k59_1068705_1 857087.Metme_0098 7.35e-38 130.0 COG2967@1|root,COG2967@2|Bacteria,1MZ2Z@1224|Proteobacteria,1S8SE@1236|Gammaproteobacteria,1XF63@135618|Methylococcales 135618|Methylococcales P ApaG domain apaG - - ko:K06195 - - - - ko00000 - - - DUF525 k59_1068705_2 522306.CAP2UW1_4137 2.69e-26 103.0 COG0639@1|root,COG0639@2|Bacteria,1MV10@1224|Proteobacteria,2VHV6@28216|Betaproteobacteria,1KPXN@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria T Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP apaH - 3.6.1.41 ko:K01525 ko00230,map00230 - R00125 RC00002 ko00000,ko00001,ko01000 - - - Metallophos k59_940197_1 1349785.BAUG01000009_gene811 8.55e-29 114.0 COG1028@1|root,COG1028@2|Bacteria,4PKKV@976|Bacteroidetes,1IJC2@117743|Flavobacteriia 976|Bacteroidetes IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_1144672_1 1121859.KB890750_gene181 7.26e-06 52.8 COG1108@1|root,COG1108@2|Bacteria,4NH3D@976|Bacteroidetes,47JST@768503|Cytophagia 976|Bacteroidetes P ABC 3 transport family mntD - - ko:K11709 ko02010,map02010 M00319 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15 - - ABC-3 k59_212551_1 414684.RC1_3193 7.71e-78 260.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,2TRHQ@28211|Alphaproteobacteria,2JPK2@204441|Rhodospirillales 204441|Rhodospirillales E glutamate synthase gltB - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_889457_1 153948.NAL212_2991 3.99e-16 82.0 COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,2VIZJ@28216|Betaproteobacteria,3722Y@32003|Nitrosomonadales 28216|Betaproteobacteria S Lysin motif - - - - - - - - - - - - LysM k59_1193250_2 365046.Rta_22330 2.82e-49 162.0 COG0369@1|root,COG0369@2|Bacteria,1QUX0@1224|Proteobacteria,2VVK4@28216|Betaproteobacteria,4AFAS@80864|Comamonadaceae 28216|Betaproteobacteria P Flavodoxin - - - ko:K06205 - - - - ko00000 - - - Flavodoxin_1 k59_1193250_3 365046.Rta_22340 0.000275 42.4 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VJJS@28216|Betaproteobacteria,4AC26@80864|Comamonadaceae 28216|Betaproteobacteria I Benzoate-CoA ligase family - - 6.2.1.25 ko:K04110 ko00362,ko00627,ko01100,ko01120,map00362,map00627,map01100,map01120 - R01422 RC00004,RC00174 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C k59_1022222_1 94624.Bpet3123 1.38e-35 132.0 COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VJH2@28216|Betaproteobacteria,3T55M@506|Alcaligenaceae 28216|Betaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - TctC k59_1022222_2 1380394.JADL01000002_gene1523 6.09e-15 70.1 2DS7S@1|root,33EWX@2|Bacteria,1NDGE@1224|Proteobacteria,2UH4Z@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_212568_1 1354722.JQLS01000008_gene2267 2.57e-175 513.0 COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TVI3@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein conserved in bacteria - - - - - - - - - - - - TctA k59_937642_1 1266914.ATUK01000014_gene2212 7.02e-81 264.0 COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,1RQK9@1236|Gammaproteobacteria,1WWPF@135613|Chromatiales 135613|Chromatiales C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.8.5.6 ko:K21307 ko00920,ko01100,ko01120,map00920,map01100,map01120 - R11487 RC00168 ko00000,ko00001,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_553759_2 667632.KB890167_gene1605 2.76e-40 138.0 COG2096@1|root,COG2096@2|Bacteria,1RDUF@1224|Proteobacteria,2VQ7P@28216|Betaproteobacteria,1K1TA@119060|Burkholderiaceae 28216|Betaproteobacteria S Adenosyltransferase yvqK GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005525,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016043,GO:0016740,GO:0016765,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019003,GO:0019438,GO:0019538,GO:0022607,GO:0030091,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0033013,GO:0033014,GO:0034641,GO:0035639,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0065003,GO:0070206,GO:0070207,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.5.1.17 ko:K00798 ko00860,ko01100,map00860,map01100 M00122 R01492,R05220,R07268 RC00533 ko00000,ko00001,ko00002,ko01000 - - - Cob_adeno_trans k59_594170_1 592316.Pat9b_2126 8.58e-12 70.1 COG2369@1|root,COG2369@2|Bacteria,1MY2T@1224|Proteobacteria,1RR6M@1236|Gammaproteobacteria,3W05T@53335|Pantoea 1236|Gammaproteobacteria S Phage Mu protein F like protein - - - - - - - - - - - - Phage_Mu_F k59_594171_1 1095769.CAHF01000022_gene334 1.76e-05 52.4 COG4733@1|root,COG4733@2|Bacteria,1R55I@1224|Proteobacteria,2VR0I@28216|Betaproteobacteria 28216|Betaproteobacteria S cellulase activity - - - - - - - - - - - - - k59_979912_1 1123392.AQWL01000013_gene2393 1.97e-141 409.0 COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,2VHC2@28216|Betaproteobacteria,1KRCZ@119069|Hydrogenophilales 119069|Hydrogenophilales H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III hemE - 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - - URO-D k59_212757_1 1121033.AUCF01000005_gene5116 7.64e-67 211.0 COG0410@1|root,COG0410@2|Bacteria,1MUR3@1224|Proteobacteria,2TSWQ@28211|Alphaproteobacteria,2JQ14@204441|Rhodospirillales 204441|Rhodospirillales E ABC transporter - - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran k59_980052_1 640081.Dsui_1637 4.28e-72 229.0 COG2070@1|root,COG2070@2|Bacteria,1N52W@1224|Proteobacteria,2VJ45@28216|Betaproteobacteria,2KVWV@206389|Rhodocyclales 206389|Rhodocyclales S 2-nitropropane dioxygenase - - 1.13.12.16 ko:K00459 ko00910,map00910 - R00025 RC02541,RC02759 ko00000,ko00001,ko01000 - - - NMO k59_511442_1 395964.KE386496_gene87 3e-70 226.0 COG0745@1|root,COG2114@1|root,COG0745@2|Bacteria,COG2114@2|Bacteria,1MV1V@1224|Proteobacteria,2U2BQ@28211|Alphaproteobacteria,3N9KG@45404|Beijerinckiaceae 28211|Alphaproteobacteria T Adenylyl- / guanylyl cyclase, catalytic domain - - - - - - - - - - - - Guanylate_cyc,Response_reg k59_724585_1 1469245.JFBG01000023_gene1221 3.65e-49 167.0 COG0169@1|root,COG0169@2|Bacteria,1MVH4@1224|Proteobacteria,1RPB7@1236|Gammaproteobacteria,1WW5V@135613|Chromatiales 135613|Chromatiales E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) aroE - 1.1.1.25 ko:K00014 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000 - - - Shikimate_DH,Shikimate_dh_N k59_1321285_1 1121930.AQXG01000001_gene1203 3.89e-73 245.0 COG0841@1|root,COG0841@2|Bacteria,4NGCI@976|Bacteroidetes 976|Bacteroidetes V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_125843_1 1504672.669785248 5.25e-35 134.0 COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,2VI47@28216|Betaproteobacteria,4AAZH@80864|Comamonadaceae 28216|Betaproteobacteria G MFS/sugar transport protein - - - - - - - - - - - - MFS_2 k59_889911_1 742159.HMPREF0004_4351 1.5e-39 145.0 COG2271@1|root,COG2271@2|Bacteria,1QU9E@1224|Proteobacteria,2WGJT@28216|Betaproteobacteria,3T37R@506|Alcaligenaceae 28216|Betaproteobacteria G Major Facilitator Superfamily fsr1 - - - - - - - - - - - MFS_1,Sugar_tr k59_168169_1 1244869.H261_18000 1.87e-79 241.0 COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,2TTE2@28211|Alphaproteobacteria,2JRY6@204441|Rhodospirillales 204441|Rhodospirillales C COG0437 Fe-S-cluster-containing hydrogenase components 1 - - - - - - - - - - - - Fer4_11,Fer4_4,Fer4_7 k59_126030_1 1347342.BN863_880 1.93e-64 211.0 COG0370@1|root,COG0370@2|Bacteria,4NGRN@976|Bacteroidetes,1I03Y@117743|Flavobacteriia 976|Bacteroidetes P transporter of a GTP-driven Fe(2 ) uptake system - - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoB_C,FeoB_N,Gate k59_126131_1 1207063.P24_15956 6.14e-51 176.0 COG0477@1|root,COG2814@2|Bacteria,1MVUF@1224|Proteobacteria,2TU4M@28211|Alphaproteobacteria,2JQ9V@204441|Rhodospirillales 204441|Rhodospirillales EGP COG0477 Permeases of the major facilitator superfamily - - - - - - - - - - - - MFS_1,Sugar_tr k59_890151_1 596154.Alide2_0304 1.33e-93 280.0 COG0596@1|root,COG0596@2|Bacteria,1NUT9@1224|Proteobacteria,2W0VU@28216|Betaproteobacteria,4AGSQ@80864|Comamonadaceae 28216|Betaproteobacteria S Alpha beta - - - - - - - - - - - - Abhydrolase_1 k59_890163_1 292415.Tbd_2287 1.4e-71 221.0 COG3647@1|root,COG3647@2|Bacteria,1N7NB@1224|Proteobacteria,2VQQJ@28216|Betaproteobacteria 28216|Betaproteobacteria S Predicted membrane protein (DUF2238) - - - ko:K08984 - - - - ko00000 - - - DUF2238 k59_1145486_1 335659.S23_07020 5.05e-40 142.0 COG3435@1|root,COG3435@2|Bacteria,1MVJP@1224|Proteobacteria,2TUUS@28211|Alphaproteobacteria,3JQZN@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria Q Cupin domain MA20_40225 - 1.13.11.4 ko:K00450 ko00350,ko01100,ko01120,map00350,map01100,map01120 - R02656 RC00764 ko00000,ko00001,ko01000 - - - Cupin_2 k59_1145486_2 1122135.KB893146_gene1617 1.66e-46 159.0 28I53@1|root,2Z88I@2|Bacteria,1NE5N@1224|Proteobacteria,2TTBB@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF3750) - - - - - - - - - - - - DUF3750 k59_168742_2 555079.Toce_2101 1.88e-24 99.8 COG0244@1|root,COG0244@2|Bacteria,1V3JJ@1239|Firmicutes,24G9R@186801|Clostridia,42GM6@68295|Thermoanaerobacterales 186801|Clostridia J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors rplJ - - ko:K02864 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L10 k59_595265_1 85643.Tmz1t_2524 9e-15 68.6 COG1977@1|root,COG1977@2|Bacteria,1N0IE@1224|Proteobacteria,2VVSP@28216|Betaproteobacteria,2KX9K@206389|Rhodocyclales 206389|Rhodocyclales H Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin moaD - - ko:K03636 ko04122,map04122 - - - ko00000,ko00001 - - - ThiS k59_595265_2 977880.RALTA_A1808 2.9e-50 171.0 COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,2VIFK@28216|Betaproteobacteria,1JZXP@119060|Burkholderiaceae 28216|Betaproteobacteria H MoeA domain protein domain I and II moeA1 - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N k59_847192_1 1049564.TevJSym_aj00540 7.97e-90 271.0 COG3954@1|root,COG3954@2|Bacteria,1MWN9@1224|Proteobacteria,1RMS7@1236|Gammaproteobacteria,1J8PV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Phosphoribulokinase / Uridine kinase family prkB GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009224,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0043771,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046035,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.7.1.19 ko:K00855 ko00710,ko01100,ko01120,ko01200,map00710,map01100,map01120,map01200 M00165,M00166 R01523 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - PRK k59_296955_1 398525.KB900701_gene7057 3.29e-19 92.4 COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S ABC transporter substrate binding protein - - - ko:K01989 - M00247 - - ko00000,ko00002,ko02000 - - - ABC_sub_bind k59_296955_2 2055.JNXA01000018_gene3591 4.96e-10 61.2 COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria,4GD7M@85026|Gordoniaceae 201174|Actinobacteria K helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg k59_168938_1 7955.ENSDARP00000121308 8.88e-08 58.9 COG2124@1|root,KOG0158@2759|Eukaryota,38BTY@33154|Opisthokonta,3BF8S@33208|Metazoa,3CV2F@33213|Bilateria,47Z83@7711|Chordata,48W40@7742|Vertebrata,49VXM@7898|Actinopterygii 33208|Metazoa Q Thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A) TBXAS1 GO:0001101,GO:0001516,GO:0001676,GO:0003008,GO:0003013,GO:0003018,GO:0003674,GO:0003824,GO:0004796,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006636,GO:0006690,GO:0006692,GO:0006693,GO:0006873,GO:0008015,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009636,GO:0009987,GO:0010033,GO:0012505,GO:0016020,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016853,GO:0016860,GO:0019229,GO:0019369,GO:0019371,GO:0019725,GO:0019752,GO:0030002,GO:0030320,GO:0030644,GO:0031984,GO:0032501,GO:0032787,GO:0033559,GO:0033993,GO:0035150,GO:0035296,GO:0036134,GO:0042175,GO:0042221,GO:0042493,GO:0042592,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044057,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0045471,GO:0045907,GO:0046394,GO:0046456,GO:0046457,GO:0046677,GO:0048518,GO:0048878,GO:0050789,GO:0050801,GO:0050880,GO:0050896,GO:0051239,GO:0051240,GO:0055064,GO:0055081,GO:0055082,GO:0055083,GO:0055114,GO:0065007,GO:0065008,GO:0070542,GO:0071704,GO:0072330,GO:0090066,GO:0097305,GO:0097746,GO:0098771,GO:0098827,GO:1901568,GO:1901570,GO:1901576,GO:1901700,GO:1903522,GO:1903524 1.14.14.1,5.3.99.5 ko:K01832,ko:K07424,ko:K17692 ko00140,ko00590,ko00591,ko00830,ko01100,ko04611,ko05204,map00140,map00590,map00591,map00830,map01100,map04611,map05204 - R02268,R02356,R03408,R07055,R07056,R08390,R08391,R08392 RC00674,RC00704,RC00723,RC00724,RC01624,RC01711 ko00000,ko00001,ko00199,ko01000 - - - p450 k59_890702_1 1150469.RSPPHO_00854 2.19e-38 142.0 COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria,2JQE2@204441|Rhodospirillales 204441|Rhodospirillales Q COG4664 TRAP-type mannitol chloroaromatic compound transport system, large permease component - - - - - - - - - - - - DctM k59_847466_1 391038.Bphy_2017 4.01e-126 373.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,2VI4G@28216|Betaproteobacteria,1K2XH@119060|Burkholderiaceae 28216|Betaproteobacteria E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) leuA - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_595646_1 1220601.L7TQW5_9CAUD 6.47e-16 83.2 4QBMV@10239|Viruses,4QUU6@35237|dsDNA viruses no RNA stage,4QQ7Y@28883|Caudovirales 28883|Caudovirales S DNA-dependent RNA polymerase - GO:0008150,GO:0016032,GO:0019080,GO:0019083,GO:0039695,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_1145997_1 479431.Namu_2110 5.62e-88 270.0 COG0006@1|root,COG0006@2|Bacteria,2H45Q@201174|Actinobacteria,4ESAX@85013|Frankiales 201174|Actinobacteria E Metallopeptidase family M24 - - - - - - - - - - - - Creatinase_N,Peptidase_M24 k59_127065_1 90814.KL370891_gene746 2.04e-41 162.0 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,1RNK8@1236|Gammaproteobacteria,460U8@72273|Thiotrichales 72273|Thiotrichales Q PFAM Hemolysin-type calcium-binding repeat (2 copies) - - - - - - - - - - - - HCBP_related,He_PIG,HemolysinCabind k59_891083_1 396588.Tgr7_2706 1.6e-42 149.0 COG0115@1|root,COG0115@2|Bacteria,1MVAT@1224|Proteobacteria,1RPU0@1236|Gammaproteobacteria,1WX40@135613|Chromatiales 135613|Chromatiales EH PFAM Aminotransferase, class IV - - 2.6.1.21 ko:K00824 ko00310,ko00330,ko00360,ko00472,ko00473,ko01100,map00310,map00330,map00360,map00472,map00473,map01100 - R01148,R01582,R02459,R02851,R02924,R05053 RC00006,RC00008,RC00025 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_4 k59_169313_1 1095769.CAHF01000021_gene882 1.22e-43 163.0 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2VIR8@28216|Betaproteobacteria,4747B@75682|Oxalobacteraceae 28216|Betaproteobacteria C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain coxL - 1.2.5.3 ko:K03520 - - R11168 RC02800 ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_847700_1 661478.OP10G_1525 2.81e-24 106.0 COG2352@1|root,COG2352@2|Bacteria 2|Bacteria C phosphoenolpyruvate carboxylase activity ppc GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 - - iJN678.ppc PEPcase k59_891498_1 1112217.PPL19_03135 0.000495 42.4 COG2307@1|root,COG2307@2|Bacteria,1MVZK@1224|Proteobacteria,1RN2Y@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - Alpha-E k59_891498_2 1215092.PA6_044_00190 7.9e-123 362.0 COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,1RNAF@1236|Gammaproteobacteria,1YCVU@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S Circularly permuted ATP-grasp type 2 - - - - - - - - - - - - CP_ATPgrasp_2 k59_90081_1 446465.Bfae_30630 1.13e-32 125.0 COG0842@1|root,COG0842@2|Bacteria,2IITR@201174|Actinobacteria 201174|Actinobacteria V Abc-2 type transporter - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane k59_346978_1 754476.Q7A_1021 1.27e-96 293.0 COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,1RMXY@1236|Gammaproteobacteria,46048@72273|Thiotrichales 72273|Thiotrichales D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring ftsA - - ko:K03590 ko04112,map04112 - - - ko00000,ko00001,ko03036,ko04812 - - - FtsA,SHS2_FTSA k59_346978_2 95619.PM1_0206665 5.46e-16 77.0 COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,1RPZS@1236|Gammaproteobacteria 1236|Gammaproteobacteria D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022607,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0051258,GO:0051301,GO:0065003,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin k59_90096_1 331869.BAL199_17093 1.84e-89 279.0 COG0008@1|root,COG0008@2|Bacteria,1MUC8@1224|Proteobacteria,2TRKX@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Glutaminyl-tRNA synthetase glnS - 6.1.1.18 ko:K01886 ko00970,ko01100,map00970,map01100 M00359,M00360 R03652 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1c,tRNA-synt_1c_C k59_218378_1 1008459.TASI_1052 4.7e-16 77.8 COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,2VHVA@28216|Betaproteobacteria,3T25I@506|Alcaligenaceae 28216|Betaproteobacteria F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG GO:0001775,GO:0002376,GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008283,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032943,GO:0034404,GO:0034641,GO:0034654,GO:0042098,GO:0042100,GO:0042110,GO:0042113,GO:0042221,GO:0042455,GO:0042493,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045321,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046649,GO:0046651,GO:0050896,GO:0055086,GO:0070661,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - - CTP_synth_N,GATase k59_218378_2 314278.NB231_01379 9.21e-63 200.0 COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,1RMGQ@1236|Gammaproteobacteria,1WWZU@135613|Chromatiales 135613|Chromatiales M 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase kdsA - 2.5.1.55 ko:K01627 ko00540,ko01100,map00540,map01100 M00063 R03254 RC00435 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DAHP_synth_1 k59_1241518_1 323848.Nmul_A0901 9.54e-50 176.0 COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,1MYXV@1224|Proteobacteria,2VJIQ@28216|Betaproteobacteria,372GH@32003|Nitrosomonadales 28216|Betaproteobacteria L DNA polymerase X family - - - ko:K02347 - - - - ko00000,ko03400 - - - DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP k59_1029803_1 395495.Lcho_0046 2.58e-20 84.7 COG0745@1|root,COG0745@2|Bacteria,1RD7E@1224|Proteobacteria,2VVWD@28216|Betaproteobacteria,1KPCJ@119065|unclassified Burkholderiales 28216|Betaproteobacteria T PFAM response regulator receiver - - - ko:K11443 ko02020,ko04112,map02020,map04112 M00511 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg k59_1029803_2 420324.KI911972_gene3030 1.02e-25 108.0 COG0642@1|root,COG2203@1|root,COG3850@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria,COG3850@2|Bacteria,1NRP8@1224|Proteobacteria,2TX3Q@28211|Alphaproteobacteria,1JXBR@119045|Methylobacteriaceae 28211|Alphaproteobacteria T GAF domain - - - - - - - - - - - - GAF,GAF_2,HAMP,HATPase_c,HisKA,Response_reg,dCache_1 k59_1198872_1 713586.KB900536_gene91 6.41e-179 520.0 COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,1RREP@1236|Gammaproteobacteria,1WWDT@135613|Chromatiales 135613|Chromatiales C PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Fer4_20,Fer4_7,Pyr_redox_2 k59_6817_1 78398.KS43_08150 1.97e-56 183.0 COG3023@1|root,COG3023@2|Bacteria,1RDHU@1224|Proteobacteria,1S3PG@1236|Gammaproteobacteria,1MQAE@122277|Pectobacterium 1236|Gammaproteobacteria V Ami_2 ampD GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008745,GO:0009056,GO:0009057,GO:0009253,GO:0009254,GO:0009392,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0019867,GO:0030203,GO:0043170,GO:0044424,GO:0044464,GO:0061783,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575 3.5.1.28 ko:K01447,ko:K03806 - - R04112 RC00064,RC00141 ko00000,ko01000,ko01011 - - iAF1260.b0110,iB21_1397.B21_00108,iBWG_1329.BWG_0103,iEC55989_1330.EC55989_0103,iECBD_1354.ECBD_3509,iECB_1328.ECB_00109,iECDH10B_1368.ECDH10B_0090,iECDH1ME8569_1439.ECDH1ME8569_0104,iECD_1391.ECD_00109,iECIAI1_1343.ECIAI1_0107,iECO103_1326.ECO103_0110,iECO111_1330.ECO111_0111,iECO26_1355.ECO26_0112,iECSE_1348.ECSE_0110,iECW_1372.ECW_m0107,iEKO11_1354.EKO11_3806,iETEC_1333.ETEC_0106,iEcDH1_1363.EcDH1_3492,iEcE24377_1341.EcE24377A_0112,iEcHS_1320.EcHS_A0114,iEcolC_1368.EcolC_3549,iJO1366.b0110,iSFV_1184.SFV_0101,iSF_1195.SF0107,iSFxv_1172.SFxv_0113,iS_1188.S0109,iUMNK88_1353.UMNK88_108,iWFL_1372.ECW_m0107,iY75_1357.Y75_RS00560 Amidase_2 k59_6817_2 1485544.JQKP01000001_gene1022 7.01e-12 65.1 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,44VDT@713636|Nitrosomonadales 28216|Betaproteobacteria T PFAM sigma-54 factor interaction domain-containing protein pilR - - ko:K02667 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - HTH_8,Response_reg,Sigma54_activat k59_1029814_1 347834.RHE_CH00782 1.52e-118 350.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,4BA4C@82115|Rhizobiaceae 28211|Alphaproteobacteria L Transposase and inactivated derivatives - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_474231_1 378806.STAUR_2726 2e-32 124.0 COG2159@1|root,COG2159@2|Bacteria,1R5PG@1224|Proteobacteria,431I4@68525|delta/epsilon subdivisions,2WW88@28221|Deltaproteobacteria,2YYBM@29|Myxococcales 28221|Deltaproteobacteria S Amidohydrolase - - 4.1.1.45 ko:K03392 ko00380,ko01100,map00380,map01100 M00038 R04323 RC00779 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_2 k59_474231_2 420324.KI911952_gene3268 2.25e-07 52.0 COG3181@1|root,COG3181@2|Bacteria,1MW18@1224|Proteobacteria,2TSKY@28211|Alphaproteobacteria,1JRPC@119045|Methylobacteriaceae 28211|Alphaproteobacteria S Tripartite tricarboxylate transporter family receptor - - - - - - - - - - - - TctC k59_687389_1 977880.RALTA_A0811 1.3e-80 266.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,2VH3F@28216|Betaproteobacteria,1K1A9@119060|Burkholderiaceae 28216|Betaproteobacteria L DNA polymerase dnaE - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_347034_1 748247.AZKH_1813 3.15e-29 120.0 COG1716@1|root,COG2114@1|root,COG1716@2|Bacteria,COG2114@2|Bacteria,1NAJG@1224|Proteobacteria,2VJW8@28216|Betaproteobacteria,2KWRJ@206389|Rhodocyclales 206389|Rhodocyclales T Forkhead associated domain - - - - - - - - - - - - FHA,Guanylate_cyc k59_347034_2 1532557.JL37_22075 1.87e-70 219.0 COG1247@1|root,COG1247@2|Bacteria,1RDHN@1224|Proteobacteria,2VQM1@28216|Betaproteobacteria,3T42Z@506|Alcaligenaceae 28216|Betaproteobacteria M Acetyltransferase pat - 2.3.1.183 ko:K03823 ko00440,ko01130,map00440,map01130 - R08871,R08938 RC00004,RC00064 ko00000,ko00001,ko01000 - - - Acetyltransf_4 k59_347034_3 762376.AXYL_01152 2.15e-13 73.2 COG0730@1|root,COG0730@2|Bacteria,1MX4T@1224|Proteobacteria,2VRZJ@28216|Betaproteobacteria,3T7T0@506|Alcaligenaceae 28216|Betaproteobacteria S Sulfite exporter TauE/SafE - - - ko:K07090 - - - - ko00000 - - - TauE k59_1072397_1 414684.RC1_3193 2.31e-109 353.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,2TRHQ@28211|Alphaproteobacteria,2JPK2@204441|Rhodospirillales 204441|Rhodospirillales E glutamate synthase gltB - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_218434_1 996637.SGM_6574 1.43e-111 343.0 COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,2GK8E@201174|Actinobacteria 201174|Actinobacteria C NADH flavin oxidoreductase NADH oxidase fadH - 1.3.1.34 ko:K00219 - - - - ko00000,ko01000 - - - Oxidored_FMN,Pyr_redox_2 k59_218434_2 502025.Hoch_1468 8.38e-18 82.4 COG0697@1|root,COG0697@2|Bacteria,1MZQM@1224|Proteobacteria,42VPN@68525|delta/epsilon subdivisions,2WRK6@28221|Deltaproteobacteria,2Z1WG@29|Myxococcales 28221|Deltaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA k59_943122_1 44251.PDUR_20920 2.14e-89 272.0 COG0667@1|root,COG0667@2|Bacteria,1TPIY@1239|Firmicutes,4HA4Q@91061|Bacilli,26S2B@186822|Paenibacillaceae 91061|Bacilli C aldo keto reductase - - - - - - - - - - - - Aldo_ket_red k59_644680_1 497964.CfE428DRAFT_2752 3.71e-13 74.3 COG2304@1|root,COG5426@1|root,COG2304@2|Bacteria,COG5426@2|Bacteria,46TJC@74201|Verrucomicrobia 74201|Verrucomicrobia S von Willebrand factor, type A - - - - - - - - - - - - - k59_559044_1 948106.AWZT01000011_gene2012 1.86e-110 326.0 COG1702@1|root,COG1702@2|Bacteria,1MVDV@1224|Proteobacteria,2VH9V@28216|Betaproteobacteria,1K00G@119060|Burkholderiaceae 28216|Betaproteobacteria T PFAM PhoH family protein ybeZ - - ko:K06217 - - - - ko00000 - - - PhoH k59_687409_1 266265.Bxe_B0378 4.99e-110 333.0 COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,2VH37@28216|Betaproteobacteria,1K2GN@119060|Burkholderiaceae 28216|Betaproteobacteria C electron transfer flavoprotein-ubiquinone oxidoreductase etf - 1.5.5.1 ko:K00311 - - - - ko00000,ko01000 - - - ETF_QO,FAD_binding_2,NAD_binding_8 k59_503195_1 83406.HDN1F_23220 2.06e-75 234.0 COG0289@1|root,COG0289@2|Bacteria,1MUCT@1224|Proteobacteria,1RMCZ@1236|Gammaproteobacteria,1J4SJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate dapB GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0042802,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.17.1.8 ko:K00215 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R04198,R04199 RC00478 ko00000,ko00001,ko00002,ko01000 - - iSbBS512_1146.SbBS512_E0035 DapB_C,DapB_N k59_1014312_2 908612.HMPREF9720_0530 8.74e-42 155.0 COG1472@1|root,COG1472@2|Bacteria,4NE90@976|Bacteroidetes,2FMCU@200643|Bacteroidia 976|Bacteroidetes G Glycosyl hydrolase family 3 - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C,PA14 k59_159715_1 1123073.KB899243_gene684 3.24e-21 101.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1S1MS@1236|Gammaproteobacteria,1X9I0@135614|Xanthomonadales 135614|Xanthomonadales T Adenylate cyclase - - - - - - - - - - - - TPR_8 k59_674383_1 1297863.APJF01000033_gene1671 8.9e-78 244.0 COG3385@1|root,COG3385@2|Bacteria,1PMXF@1224|Proteobacteria,2U1D5@28211|Alphaproteobacteria,3JXTT@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1,DUF4372 k59_1064733_1 396588.Tgr7_0458 7.18e-07 58.5 COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,1RR36@1236|Gammaproteobacteria,1WYS8@135613|Chromatiales 135613|Chromatiales KLT serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - HAMP,HEAT_2,Pkinase,sCache_3_2 k59_545862_1 247639.MGP2080_05657 8.32e-73 232.0 COG1196@1|root,COG1196@2|Bacteria,1R4BS@1224|Proteobacteria,1S13B@1236|Gammaproteobacteria,1J7UD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D von Willebrand factor (VWF) type A domain - - - - - - - - - - - - VWA_2 k59_545862_2 876044.IMCC3088_857 1.82e-13 70.1 COG2304@1|root,COG2304@2|Bacteria,1QBPM@1224|Proteobacteria,1RQIU@1236|Gammaproteobacteria,1J4PZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Secreted protein, containing von Willebrand factor (VWF) type - - - - - - - - - - - - - k59_379487_1 103690.17130349 4e-06 48.1 COG4446@1|root,COG4446@2|Bacteria,1G6W2@1117|Cyanobacteria,1HNRG@1161|Nostocales 1117|Cyanobacteria S Protein of unknown function (DUF1499) - - - - - - - - - - - - DUF1499 k59_1138022_1 987059.RBXJA2T_01760 4.23e-109 343.0 COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,2VH05@28216|Betaproteobacteria,1KJWN@119065|unclassified Burkholderiales 28216|Betaproteobacteria EI Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly icmF GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0006139,GO:0006163,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016866,GO:0017076,GO:0017111,GO:0019001,GO:0019637,GO:0019693,GO:0019842,GO:0031419,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0034784,GO:0035383,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043603,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046872,GO:0046906,GO:0047727,GO:0048037,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564 5.4.99.13 ko:K11942 - - - - ko00000,ko01000 - - - ArgK,B12-binding,MM_CoA_mutase k59_805662_1 1207063.P24_11897 1.71e-21 98.2 COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,2TVYU@28211|Alphaproteobacteria,2JQP4@204441|Rhodospirillales 204441|Rhodospirillales EQ Hydantoinase B/oxoprolinase - - - - - - - - - - - - Hydantoinase_B k59_117548_1 1123355.JHYO01000036_gene621 2.85e-72 224.0 COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,2TTKG@28211|Alphaproteobacteria,36XZR@31993|Methylocystaceae 28211|Alphaproteobacteria T Transcriptional regulatory protein, C terminal - - - ko:K02483 - - - - ko00000,ko02022 - - - Guanylate_cyc,Response_reg,Trans_reg_C k59_117562_2 1331060.RLDS_01755 2.14e-10 58.5 COG3686@1|root,COG3686@2|Bacteria,1RAEH@1224|Proteobacteria,2U5JJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria S MAPEG family MA20_30600 - - - - - - - - - - - MAPEG k59_716476_1 326424.FRAAL5646 7.73e-07 50.8 COG0609@1|root,COG0609@2|Bacteria,2GK8Z@201174|Actinobacteria,4EVCR@85013|Frankiales 201174|Actinobacteria P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily fecD - - ko:K02015 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - FecCD k59_716483_1 391615.ABSJ01000026_gene110 6.85e-64 206.0 COG0607@1|root,COG0664@1|root,COG0607@2|Bacteria,COG0664@2|Bacteria,1R9Q1@1224|Proteobacteria,1RSKD@1236|Gammaproteobacteria,1J6A4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria PT COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases - - - - - - - - - - - - Rhodanese,cNMP_binding k59_1185444_1 331869.BAL199_14527 7.88e-17 80.1 COG2055@1|root,COG2055@2|Bacteria,1MWQY@1224|Proteobacteria,2TR37@28211|Alphaproteobacteria,4BRHK@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria C Malate/L-lactate dehydrogenase - - 1.1.1.27,1.1.1.350 ko:K00016,ko:K00073 ko00010,ko00230,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00230,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922 - R00703,R01000,R02935,R02936,R03104 RC00031,RC00044,RC00169 ko00000,ko00001,ko01000,ko04147 - - - Ldh_2 k59_1185444_2 1280947.HY30_15930 1.38e-32 121.0 COG2030@1|root,COG2030@2|Bacteria,1MUR2@1224|Proteobacteria,2TUM7@28211|Alphaproteobacteria 28211|Alphaproteobacteria I dehydratase - - - - - - - - - - - - MaoC_dehydrat_N,MaoC_dehydratas k59_674486_1 1510531.JQJJ01000009_gene644 8.21e-88 271.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2TQND@28211|Alphaproteobacteria,3JRVX@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 2.6.1.18 ko:K00822 ko00280,ko00410,ko00640,ko01100,map00280,map00410,map00640,map01100 - R00907,R04187 RC00008,RC00062,RC00160 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_3 k59_674490_1 697282.Mettu_1352 0.000265 44.7 COG1947@1|root,COG1947@2|Bacteria,1MVU3@1224|Proteobacteria,1RP23@1236|Gammaproteobacteria,1XE84@135618|Methylococcales 135618|Methylococcales F Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol ispE - 2.7.1.148 ko:K00919 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05634 RC00002,RC01439 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N k59_674490_2 243365.CV_4058 1.17e-31 119.0 COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,2VHU0@28216|Betaproteobacteria,2KPJF@206351|Neisseriales 206351|Neisseriales F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran_N k59_287921_1 323261.Noc_1226 9.79e-19 91.3 COG0421@1|root,COG0421@2|Bacteria,1N1PJ@1224|Proteobacteria,1T2R5@1236|Gammaproteobacteria,1WZ7X@135613|Chromatiales 135613|Chromatiales E Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - - - - - - - - - - - k59_460864_1 414684.RC1_2977 1.03e-67 217.0 COG1702@1|root,COG1702@2|Bacteria,1MVDV@1224|Proteobacteria,2TRV3@28211|Alphaproteobacteria,2JPRI@204441|Rhodospirillales 204441|Rhodospirillales T COG1702 Phosphate starvation-inducible protein PhoH ybeZ - - ko:K06217 - - - - ko00000 - - - PhoH k59_248125_1 28229.ND2E_3508 5.12e-43 156.0 COG0811@1|root,COG0811@2|Bacteria,1MX5J@1224|Proteobacteria,1RMSA@1236|Gammaproteobacteria,2Q80B@267889|Colwelliaceae 1236|Gammaproteobacteria U MotA/TolQ/ExbB proton channel family - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_248157_1 323848.Nmul_A0857 4.97e-105 330.0 COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,2VJ0G@28216|Betaproteobacteria,371W3@32003|Nitrosomonadales 28216|Betaproteobacteria C dehydrogenase, E1 component sucA - 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_805800_1 398527.Bphyt_0126 3.81e-23 100.0 COG3916@1|root,COG3916@2|Bacteria,1NAB4@1224|Proteobacteria,2WGB1@28216|Betaproteobacteria,1K8DJ@119060|Burkholderiaceae 28216|Betaproteobacteria H Acyl-homoserine-lactone synthase - - 2.3.1.184 ko:K20250 ko00270,ko01100,ko02024,map00270,map01100,map02024 - R08940 RC00021,RC00039 ko00000,ko00001,ko01000 - - - Autoind_synth k59_418927_1 266834.SMc02255 8.59e-55 184.0 COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,2TQMA@28211|Alphaproteobacteria,4B8K1@82115|Rhizobiaceae 28211|Alphaproteobacteria C oxidase, subunit cydA - 1.10.3.14 ko:K00425 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_I k59_839665_1 626418.bglu_1g30860 2.72e-141 438.0 COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU43@1224|Proteobacteria,2VHYU@28216|Betaproteobacteria,1K40G@119060|Burkholderiaceae 28216|Betaproteobacteria C FAD linked oxidase domain protein glpCD - - - - - - - - - - - CCG,DUF3400,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_8 k59_379685_1 536233.CLO_1839 0.000951 43.5 2EF94@1|root,33920@2|Bacteria,1VIXN@1239|Firmicutes,24U6R@186801|Clostridia,36N3P@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - k59_1014626_1 1122605.KB893649_gene3777 8.21e-07 54.3 COG3119@1|root,COG3119@2|Bacteria,4NEFN@976|Bacteroidetes,1IQ0C@117747|Sphingobacteriia 976|Bacteroidetes P Sulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - DUF4994,Sulfatase k59_117809_1 305700.B447_16492 9.66e-84 271.0 COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,2VH74@28216|Betaproteobacteria,2KVA2@206389|Rhodocyclales 206389|Rhodocyclales K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth rpoD - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_882942_1 247634.GPB2148_1664 4.86e-66 225.0 COG1060@1|root,COG1060@2|Bacteria,1MX50@1224|Proteobacteria,1RSCG@1236|Gammaproteobacteria,1J4W0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Elongator protein 3, MiaB family, Radical SAM - - 2.5.1.77 ko:K11779 ko00680,ko01120,map00680,map01120 M00378 R09396 RC01381,RC03002,RC03007 ko00000,ko00001,ko00002,ko01000 - - - CofC,Radical_SAM k59_1228526_1 344747.PM8797T_24191 9.19e-11 70.5 COG1864@1|root,COG2931@1|root,COG3391@1|root,COG1864@2|Bacteria,COG2931@2|Bacteria,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - 3.1.3.1 ko:K01113,ko:K01173 ko00790,ko01100,ko02020,ko04210,map00790,map01100,map02020,map04210 M00126 R04620 RC00017 ko00000,ko00001,ko00002,ko01000,ko03029 - - - DUF4114,Endonuclea_NS_2 k59_1228526_2 1217718.ALOU01000020_gene2170 2.81e-08 56.6 COG1281@1|root,COG1281@2|Bacteria,1MUMU@1224|Proteobacteria,2VI8B@28216|Betaproteobacteria,1K4UW@119060|Burkholderiaceae 28216|Betaproteobacteria O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress hslO - - ko:K04083 - - - - ko00000,ko03110 - - - HSP33 k59_674769_1 1304883.KI912532_gene2789 6.61e-69 217.0 COG0596@1|root,COG0596@2|Bacteria,1MVVX@1224|Proteobacteria,2VH81@28216|Betaproteobacteria,2KVGE@206389|Rhodocyclales 206389|Rhodocyclales S hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_1107349_1 588932.JHOF01000027_gene1529 3.69e-37 138.0 COG2021@1|root,COG2021@2|Bacteria,1PNUE@1224|Proteobacteria,2V1DE@28211|Alphaproteobacteria,2KGUU@204458|Caulobacterales 204458|Caulobacterales E Belongs to the AB hydrolase superfamily. MetX family - - 2.3.1.31 ko:K00641 ko00270,ko01100,ko01130,map00270,map01100,map01130 - R01776 RC00004,RC00041 ko00000,ko00001,ko01000 - - - Abhydrolase_1 k59_248374_1 748247.AZKH_2214 1.4e-46 166.0 COG3290@1|root,COG4191@1|root,COG3290@2|Bacteria,COG4191@2|Bacteria,1R8JK@1224|Proteobacteria,2WEZZ@28216|Betaproteobacteria 28216|Betaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA k59_638507_1 1380394.JADL01000001_gene2218 7.71e-21 90.1 COG2186@1|root,COG2186@2|Bacteria,1R68P@1224|Proteobacteria,2U9AP@28211|Alphaproteobacteria,2JWFN@204441|Rhodospirillales 204441|Rhodospirillales K FCD - - - - - - - - - - - - FCD,GntR k59_638507_2 446469.Sked_24470 9.09e-14 72.4 COG2141@1|root,COG2141@2|Bacteria,2GIY3@201174|Actinobacteria 201174|Actinobacteria C F420-dependent oxidoreductase - - - - - - - - - - - - Bac_luciferase k59_806043_1 568706.BN118_0438 1.82e-19 84.7 COG1028@1|root,COG1028@2|Bacteria,1MUFX@1224|Proteobacteria,2VMB3@28216|Betaproteobacteria,3T2EV@506|Alcaligenaceae 28216|Betaproteobacteria IQ Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis tsaC GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0010130,GO:0016043,GO:0016491,GO:0016614,GO:0016616,GO:0018913,GO:0018915,GO:0022607,GO:0042537,GO:0043933,GO:0044085,GO:0044237,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:1901360 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_1014812_1 1189619.pgond44_14073 4.54e-33 132.0 COG0642@1|root,COG4191@1|root,COG2205@2|Bacteria,COG4191@2|Bacteria,4NEJX@976|Bacteroidetes,1I0JH@117743|Flavobacteriia 976|Bacteroidetes T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - 7TMR-DISMED2,7TMR-DISM_7TM,HATPase_c,HisKA,TPR_12,TPR_7 k59_1138375_1 518766.Rmar_1751 4.89e-45 165.0 COG3118@1|root,COG3118@2|Bacteria,4PND9@976|Bacteroidetes 976|Bacteroidetes O ASPIC and UnbV - - - - - - - - - - - - UnbV_ASPIC,VCBS k59_288290_1 398511.BpOF4_08800 1.67e-18 86.3 COG1595@1|root,COG1595@2|Bacteria,1TS3M@1239|Firmicutes,4HC17@91061|Bacilli,1ZCZ4@1386|Bacillus 91061|Bacilli K Belongs to the sigma-70 factor family. ECF subfamily sigW - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_288290_2 438753.AZC_4401 8.28e-15 72.0 COG3665@1|root,COG3665@2|Bacteria,1N9DM@1224|Proteobacteria,2TU1Z@28211|Alphaproteobacteria,3F0HC@335928|Xanthobacteraceae 28211|Alphaproteobacteria S Domain of unknown function (DUF1989) - - - ko:K09967 - - - - ko00000 - - - DUF1989 k59_1138403_1 384765.SIAM614_06683 7.31e-15 79.0 COG3773@1|root,COG3773@2|Bacteria,1MWX3@1224|Proteobacteria,2TT15@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Cell wall hydrolyses involved in spore germination sleB - - - - - - - - - - - Hydrolase_2 k59_806131_1 693986.MOC_3153 5.25e-98 293.0 COG0223@1|root,COG0223@2|Bacteria,1MW07@1224|Proteobacteria,2U0GD@28211|Alphaproteobacteria,1JSQ7@119045|Methylobacteriaceae 28211|Alphaproteobacteria H PFAM formyl transferase domain protein - - 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - - Formyl_trans_C,Formyl_trans_N k59_205266_1 1121456.ATVA01000003_gene3026 7.02e-41 154.0 COG1042@1|root,COG1042@2|Bacteria,1NU6B@1224|Proteobacteria,42NAU@68525|delta/epsilon subdivisions,2WJHX@28221|Deltaproteobacteria,2M8HI@213115|Desulfovibrionales 28221|Deltaproteobacteria C ATP-grasp domain - - - - - - - - - - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig k59_716956_1 1144310.PMI07_006469 1.7e-17 84.7 COG0477@1|root,COG2814@2|Bacteria,1QTX0@1224|Proteobacteria,2TX00@28211|Alphaproteobacteria,4BFVZ@82115|Rhizobiaceae 28211|Alphaproteobacteria EGP Transmembrane secretion effector - - - ko:K08217 - - - - br01600,ko00000,ko01504,ko02000 2.A.1.21.1,2.A.1.21.22 - - MFS_1,MFS_3 k59_461326_1 414684.RC1_1018 6.52e-87 267.0 COG1960@1|root,COG1960@2|Bacteria,1MU2V@1224|Proteobacteria,2TSK3@28211|Alphaproteobacteria,2JQ01@204441|Rhodospirillales 204441|Rhodospirillales I Acyl-CoA dehydrogenase, C-terminal domain - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1185926_1 1122614.JHZF01000020_gene133 1.77e-62 215.0 COG1042@1|root,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2TR24@28211|Alphaproteobacteria,2PDUB@252301|Oceanicola 28211|Alphaproteobacteria C CoA binding domain - - - - - - - - - - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig k59_1065414_1 316055.RPE_0838 1.13e-34 127.0 COG0518@1|root,COG0518@2|Bacteria,1MUDH@1224|Proteobacteria,2TU60@28211|Alphaproteobacteria,3JWHT@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria F glutamine amidotransferase - - - - - - - - - - - - GATase k59_205279_1 1458275.AZ34_08620 1.48e-109 327.0 COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,2VIWB@28216|Betaproteobacteria,4AAKI@80864|Comamonadaceae 28216|Betaproteobacteria C Belongs to the heme-copper respiratory oxidase family ccoN - 1.9.3.1 ko:K00404 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - COX1 k59_1313779_1 864069.MicloDRAFT_00045000 1.76e-61 197.0 COG2041@1|root,COG2041@2|Bacteria,1MUW0@1224|Proteobacteria,2TS40@28211|Alphaproteobacteria,1JS80@119045|Methylobacteriaceae 28211|Alphaproteobacteria S Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide msrP - - ko:K07147 - - - - ko00000,ko01000 - - - Oxidored_molyb k59_1313779_2 84531.JMTZ01000022_gene4197 2.5e-05 47.0 COG2717@1|root,COG2717@2|Bacteria,1RDUP@1224|Proteobacteria,1RS9K@1236|Gammaproteobacteria,1X631@135614|Xanthomonadales 135614|Xanthomonadales C Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain msrQ - - ko:K17247 - - - - ko00000 - - - Ferric_reduct k59_638682_1 1236959.BAMT01000001_gene1711 1.5e-42 152.0 COG2829@1|root,COG2829@2|Bacteria,1PC8I@1224|Proteobacteria,2VMT8@28216|Betaproteobacteria,2KNB2@206350|Nitrosomonadales 206350|Nitrosomonadales M Phospholipase A1 - - - - - - - - - - - - PLA1 k59_759475_1 1380380.JIAX01000011_gene2487 4.27e-69 215.0 COG0107@1|root,COG0107@2|Bacteria,1MUS0@1224|Proteobacteria,2TQXD@28211|Alphaproteobacteria 28211|Alphaproteobacteria E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit hisF GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 - ko:K02500 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth k59_759475_2 269796.Rru_A3595 5.07e-08 53.5 COG0106@1|root,COG0106@2|Bacteria,1MW6S@1224|Proteobacteria,2TRSG@28211|Alphaproteobacteria,2JPAY@204441|Rhodospirillales 204441|Rhodospirillales E 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase hisA - 5.3.1.16 ko:K01814 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04640 RC00945 ko00000,ko00001,ko00002,ko01000 - - - Acetyltransf_1,His_biosynth k59_37225_1 1123355.JHYO01000013_gene1073 2.32e-126 387.0 COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,2TSFS@28211|Alphaproteobacteria 28211|Alphaproteobacteria P COG0471 Di- and tricarboxylate transporters - - - - - - - - - - - - CitMHS,TrkA_C k59_586826_2 398578.Daci_3002 2.83e-24 100.0 COG1595@1|root,COG1595@2|Bacteria,1MZMC@1224|Proteobacteria,2VSEK@28216|Betaproteobacteria,4AE5F@80864|Comamonadaceae 28216|Betaproteobacteria K RNA polymerase, sigma-24 subunit, ECF subfamily rpoE8 - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_419413_1 324925.Ppha_0811 2.69e-21 86.7 COG2010@1|root,COG2010@2|Bacteria,1FFE7@1090|Chlorobi 1090|Chlorobi C Cytochrome C oxidase, cbb3-type, subunit III - - - ko:K17223 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - Cytochrom_C,Cytochrome_CBB3 k59_419413_2 1122599.AUGR01000032_gene42 7.4e-15 72.4 COG5501@1|root,COG5501@2|Bacteria,1RH4J@1224|Proteobacteria,1S4ZT@1236|Gammaproteobacteria,1XJHP@135619|Oceanospirillales 135619|Oceanospirillales S Sulfur oxidation protein SoxY - - - - - - - - - - - - SoxY k59_978612_2 1298867.AUES01000041_gene897 2.34e-26 105.0 COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,2TYVX@28211|Alphaproteobacteria,3JWZ3@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Zinc-binding dehydrogenase - - - - - - - - - - - - ADH_N,ADH_zinc_N,ADH_zinc_N_2 k59_467459_1 153948.NAL212_0300 4.28e-23 101.0 COG0472@1|root,COG0472@2|Bacteria,1MWYW@1224|Proteobacteria,2VNAG@28216|Betaproteobacteria,372PJ@32003|Nitrosomonadales 28216|Betaproteobacteria M Glycosyl transferase family 4 wbiH - - ko:K13007 - - - - ko00000,ko01000,ko01003,ko01005 - - - Glycos_transf_4 k59_978689_1 323848.Nmul_A0792 7.21e-112 330.0 COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,2VHG6@28216|Betaproteobacteria,372HG@32003|Nitrosomonadales 28216|Betaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L k59_681053_1 1245469.S58_25100 4.36e-05 50.8 COG4122@1|root,COG4122@2|Bacteria,1MYYK@1224|Proteobacteria,2UADT@28211|Alphaproteobacteria,3K3CV@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Macrocin-O-methyltransferase (TylF) - - - - - - - - - - - - TylF k59_936498_1 882378.RBRH_03066 4.04e-30 109.0 COG4453@1|root,COG4453@2|Bacteria,1N7K8@1224|Proteobacteria,2VTUT@28216|Betaproteobacteria,1K9UZ@119060|Burkholderiaceae 28216|Betaproteobacteria S Protein of unknown function (DUF1778) - - - - - - - - - - - - DUF1778 k59_936498_2 291112.PAU_pPAU1_0010 5.06e-30 112.0 COG0454@1|root,COG0454@2|Bacteria,1RHV9@1224|Proteobacteria,1S76Y@1236|Gammaproteobacteria 1236|Gammaproteobacteria K histone acetyltransferase HPA2 and related acetyltransferases - - - - - - - - - - - - Acetyltransf_7 k59_124295_1 1500894.JQNN01000001_gene159 1.9e-14 75.1 COG3614@1|root,COG4585@1|root,COG3614@2|Bacteria,COG4585@2|Bacteria 2|Bacteria T Histidine kinase - - - - - - - - - - - - CHASE,HATPase_c,HisKA_3 k59_124295_2 977880.pRALTA_0290 3.88e-25 100.0 COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,2VME6@28216|Betaproteobacteria,1K3H4@119060|Burkholderiaceae 28216|Betaproteobacteria KT response regulator - - - - - - - - - - - - GerE,Response_reg k59_1234987_1 1122135.KB893168_gene1842 8.12e-43 166.0 COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,2TRKK@28211|Alphaproteobacteria 28211|Alphaproteobacteria M mechanosensitive ion channel kefA - - ko:K05802 - - - - ko00000,ko02000 1.A.23.1.1 - - DUF3772,MS_channel k59_467609_1 481448.Minf_2460 1.08e-17 83.6 COG0438@1|root,COG0438@2|Bacteria,46VPZ@74201|Verrucomicrobia,37FUK@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia M transferase activity, transferring glycosyl groups - - - - - - - - - - - - - k59_1192244_2 1234364.AMSF01000086_gene2826 6.9e-46 156.0 COG1595@1|root,COG1595@2|Bacteria,1R9WC@1224|Proteobacteria,1SA30@1236|Gammaproteobacteria,1X3FW@135614|Xanthomonadales 135614|Xanthomonadales K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_1192263_1 1268622.AVS7_04639 2.09e-88 271.0 COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,2VKB2@28216|Betaproteobacteria,4AH37@80864|Comamonadaceae 28216|Betaproteobacteria E Receptor family ligand binding region - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_617648_2 266264.Rmet_0542 2.15e-65 211.0 COG0208@1|root,COG0208@2|Bacteria,1R4T3@1224|Proteobacteria,2VMCZ@28216|Betaproteobacteria,1K6MT@119060|Burkholderiaceae 28216|Betaproteobacteria F P-aminobenzoate N-oxygenase AurF - - - - - - - - - - - - AurF k59_1253254_2 402881.Plav_2089 1.29e-08 56.6 COG1028@1|root,COG1028@2|Bacteria,1MVQW@1224|Proteobacteria,2TUA2@28211|Alphaproteobacteria,1JN3B@119043|Rhodobiaceae 28211|Alphaproteobacteria IQ KR domain bacC - 1.1.1.159 ko:K00076 ko00121,map00121 - - - ko00000,ko00001,ko01000 - - - adh_short_C2 k59_912131_1 1306990.BARG01000109_gene9836 1.36e-44 152.0 COG0596@1|root,COG0596@2|Bacteria,2HEMJ@201174|Actinobacteria 201174|Actinobacteria E hydrolases or acyltransferases alpha beta hydrolase superfamily - - - - - - - - - - - - Abhydrolase_6 k59_1210549_1 94624.Bpet2538 8.62e-81 256.0 COG1249@1|root,COG1249@2|Bacteria,1MXQ3@1224|Proteobacteria,2VK4G@28216|Betaproteobacteria,3T2SZ@506|Alcaligenaceae 28216|Betaproteobacteria C Catalyzes the oxidation of dihydrolipoamide to lipoamide pdhD - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim k59_655868_1 1207063.P24_06212 2.74e-36 132.0 COG2854@1|root,COG2854@2|Bacteria,1NKFA@1224|Proteobacteria,2UAPV@28211|Alphaproteobacteria,2JSSQ@204441|Rhodospirillales 204441|Rhodospirillales Q COG2854 ABC-type transport system involved in resistance to organic solvents, auxiliary component - - - ko:K07323 ko02010,map02010 M00210 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27.3 - - MlaC k59_569171_1 745411.B3C1_15477 7.52e-45 152.0 COG0164@1|root,COG0164@2|Bacteria,1RA65@1224|Proteobacteria,1RQ4B@1236|Gammaproteobacteria,1J5VG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhB GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 ko:K03470 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_HII k59_443257_1 1218076.BAYB01000022_gene3982 9.57e-18 87.4 COG0457@1|root,COG0457@2|Bacteria,1MUZK@1224|Proteobacteria,2VHVG@28216|Betaproteobacteria,1KGHM@119060|Burkholderiaceae 28216|Betaproteobacteria M repeat-containing protein - - - - - - - - - - - - Glyco_transf_9,TPR_1,TPR_11,TPR_16,TPR_2,TPR_8 k59_1210627_1 296591.Bpro_2004 1.33e-116 342.0 COG2358@1|root,COG2358@2|Bacteria,1MXW1@1224|Proteobacteria,2VH6G@28216|Betaproteobacteria,4ABRZ@80864|Comamonadaceae 28216|Betaproteobacteria S NMT1-like family - - - ko:K07080 - - - - ko00000 - - - NMT1_3 k59_1341828_1 402881.Plav_2765 3.92e-93 285.0 COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,2TQVF@28211|Alphaproteobacteria,1JNND@119043|Rhodobiaceae 28211|Alphaproteobacteria L MgsA AAA+ ATPase C terminal rarA GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0030894,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901576 - ko:K07478 - - - - ko00000 - - - AAA,AAA_assoc_2,MgsA_C,RuvB_N k59_270925_2 1238182.C882_1323 1.66e-58 183.0 COG2963@1|root,COG2963@2|Bacteria,1RHKX@1224|Proteobacteria,2U9TV@28211|Alphaproteobacteria,2JX3Z@204441|Rhodospirillales 204441|Rhodospirillales L Transposase - - - - - - - - - - - - HTH_Tnp_1 k59_270925_3 1122963.AUHB01000003_gene4156 4.12e-07 51.6 COG0845@1|root,COG0845@2|Bacteria,1MUG6@1224|Proteobacteria,2TTRG@28211|Alphaproteobacteria,371GG@31993|Methylocystaceae 28211|Alphaproteobacteria M Biotin-lipoyl like - - - ko:K01993 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_485951_1 471854.Dfer_4556 3.21e-29 117.0 COG0673@1|root,COG0673@2|Bacteria,4NEN5@976|Bacteroidetes,47JNX@768503|Cytophagia 976|Bacteroidetes S PFAM Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_485951_2 1298865.H978DRAFT_3147 5.55e-08 54.3 COG0477@1|root,COG2814@2|Bacteria,1QWEI@1224|Proteobacteria,1T3J4@1236|Gammaproteobacteria,46D5S@72275|Alteromonadaceae 1236|Gammaproteobacteria EGP LacY proton/sugar symporter - - - ko:K05820 - - - - ko00000,ko02000 2.A.1.27 - - Nuc_H_symport k59_528627_2 575788.VS_1436 1.73e-10 61.2 2AWQ6@1|root,31NM4@2|Bacteria,1QKBR@1224|Proteobacteria,1TIF6@1236|Gammaproteobacteria,1XZ0V@135623|Vibrionales 135623|Vibrionales - - - - - - - - - - - - - - - k59_229716_1 311424.DhcVS_503 2.8e-134 393.0 COG0055@1|root,COG0055@2|Bacteria,2G5JI@200795|Chloroflexi,34D3I@301297|Dehalococcoidia 301297|Dehalococcoidia F Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N k59_319526_1 402881.Plav_1807 1.94e-25 104.0 COG1960@1|root,COG1960@2|Bacteria,1MVJC@1224|Proteobacteria,2TQRA@28211|Alphaproteobacteria,1JPS7@119043|Rhodobiaceae 28211|Alphaproteobacteria C Acyl-CoA dehydrogenase, N-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_319526_2 1265310.CCBD010000050_gene1878 1.26e-05 47.8 COG1028@1|root,COG2072@1|root,COG1028@2|Bacteria,COG2072@2|Bacteria,2GJEA@201174|Actinobacteria,233PF@1762|Mycobacteriaceae 201174|Actinobacteria P Flavoprotein involved in K transport - - - - - - - - - - - - FMO-like,K_oxygenase,Pyr_redox_3 k59_142908_1 331869.BAL199_27476 3.7e-76 250.0 COG0654@1|root,COG1902@1|root,COG0654@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,2TQPY@28211|Alphaproteobacteria,4BR6E@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria CH NADH:flavin oxidoreductase / NADH oxidase family - - 1.14.13.40 ko:K09461 ko00627,ko01120,map00627,map01120 - R03998,R03999 RC00244 ko00000,ko00001,ko01000 - - - FAD_binding_3,Oxidored_FMN k59_142908_2 93220.LV28_06220 3.42e-15 74.3 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VJJS@28216|Betaproteobacteria,1K23H@119060|Burkholderiaceae 28216|Betaproteobacteria I Amp-dependent synthetase and ligase bclA_1 - 6.2.1.32 ko:K08295 ko00627,ko01120,map00627,map01120 - R00982 RC00004,RC00174 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C k59_824559_1 1144342.PMI40_02473 3.54e-104 313.0 COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,2VISB@28216|Betaproteobacteria,472TI@75682|Oxalobacteraceae 28216|Betaproteobacteria I PFAM Carbamoyl-phosphate synthase L chain, ATP binding domain, Biotin carboxylase C-terminal domain, Carbamoyl-phosphate synthase L chain, N-terminal domain accC GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_319573_2 234267.Acid_6786 3.18e-09 61.6 COG2204@1|root,COG2204@2|Bacteria,3Y3HH@57723|Acidobacteria 57723|Acidobacteria T Two component, sigma54 specific, transcriptional regulator, Fis family - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_319573_3 1157708.KB907453_gene4317 2.07e-11 63.5 COG1011@1|root,COG1011@2|Bacteria,1MU1H@1224|Proteobacteria,2VN8N@28216|Betaproteobacteria,4ABG2@80864|Comamonadaceae 28216|Betaproteobacteria S HAD-superfamily hydrolase, subfamily IA, variant 2 (HAD-like) - - 3.8.1.2 ko:K01560 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 - R05287 RC00697 ko00000,ko00001,ko01000 - - - HAD_2,Hydrolase k59_699219_1 59538.XP_005974321.1 1.27e-37 137.0 COG4799@1|root,KOG0540@2759|Eukaryota 2759|Eukaryota I CoA carboxylase activity - - - - - - - - - - - - Biotin_lipoyl,Carboxyl_trans,HMGL-like,PYC_OADA k59_699219_2 1123487.KB892838_gene3864 4.05e-122 363.0 COG0285@1|root,COG0285@2|Bacteria,1MVCH@1224|Proteobacteria,2VI0H@28216|Betaproteobacteria,2KV9G@206389|Rhodocyclales 206389|Rhodocyclales H Belongs to the folylpolyglutamate synthase family folC - 6.3.2.12,6.3.2.17 ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 - - - Mur_ligase_M k59_1295130_1 548479.HMPREF0573_11645 9.05e-08 59.3 COG0553@1|root,COG0553@2|Bacteria,2GISC@201174|Actinobacteria,4D3XH@85005|Actinomycetales 201174|Actinobacteria KL SNF2 family N-terminal domain protein helZ - - - - - - - - - - - Helicase_C,SNF2_N,SNF2_assoc,SWIM k59_486036_1 258594.RPA0479 8.51e-22 93.6 COG1028@1|root,COG1028@2|Bacteria,1PEWK@1224|Proteobacteria,2TV4E@28211|Alphaproteobacteria,3JS5C@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria IQ KR domain MA20_40070 - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_486036_2 1121861.KB899917_gene3618 1.56e-31 115.0 2BQVQ@1|root,32JSN@2|Bacteria,1RJK4@1224|Proteobacteria,2UAA6@28211|Alphaproteobacteria,2JXH7@204441|Rhodospirillales 204441|Rhodospirillales S L-2-amino-thiazoline-4-carboxylic acid hydrolase - - - - - - - - - - - - ATC_hydrolase k59_1253454_2 381666.H16_B1091 1.6e-41 144.0 COG3132@1|root,COG3132@2|Bacteria,1RA13@1224|Proteobacteria,2VQGS@28216|Betaproteobacteria,1K31Q@119060|Burkholderiaceae 28216|Betaproteobacteria S Belongs to the UPF0502 family yceH - - ko:K09915 - - - - ko00000 - - - DUF480 k59_229781_1 381666.H16_A0416 1.57e-19 87.8 COG4967@1|root,COG4967@2|Bacteria,1RFJT@1224|Proteobacteria,2W17Y@28216|Betaproteobacteria,1KCQM@119060|Burkholderiaceae 28216|Betaproteobacteria NU type IV pilus assembly protein PilV - - - ko:K02671 - - - - ko00000,ko02035,ko02044 - - - N_methyl k59_997370_1 511.JT27_17000 1.19e-63 208.0 COG0421@1|root,COG1586@1|root,COG0421@2|Bacteria,COG1586@2|Bacteria,1MVV5@1224|Proteobacteria,2WGFP@28216|Betaproteobacteria,3T9I0@506|Alcaligenaceae 28216|Betaproteobacteria E Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine speE - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - AdoMet_dc,Spermine_synt_N,Spermine_synth k59_1168086_1 1165096.ARWF01000001_gene739 1.1e-61 211.0 COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,2VIAH@28216|Betaproteobacteria,2KKET@206350|Nitrosomonadales 206350|Nitrosomonadales C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) - - 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N k59_271036_1 999541.bgla_2g16060 9.86e-52 171.0 COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,2VI0K@28216|Betaproteobacteria,1K24U@119060|Burkholderiaceae 28216|Betaproteobacteria KT response regulator - - - ko:K02483 - - - - ko00000,ko02022 - - - Response_reg,Trans_reg_C k59_1044423_1 319003.Bra1253DRAFT_03704 1.73e-09 58.9 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TSGZ@28211|Alphaproteobacteria,3JUDN@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L IS116 IS110 IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_699282_1 1410620.SHLA_52c000430 5.57e-76 241.0 COG0665@1|root,COG0665@2|Bacteria,1MVIZ@1224|Proteobacteria,2TSQI@28211|Alphaproteobacteria,4B8S9@82115|Rhizobiaceae 28211|Alphaproteobacteria E Glycine D-amino acid oxidases (deaminating) MA20_29210 - 1.4.5.1 ko:K00285 ko00360,map00360 - R01374,R09493 RC00006,RC00025 ko00000,ko00001,ko01000 - - - DAO k59_618015_1 522306.CAP2UW1_2887 4.58e-69 233.0 COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,2VHCS@28216|Betaproteobacteria,1KR7N@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria L DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase dnaE2 - 2.7.7.7 ko:K14162 - - - - ko00000,ko01000,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_100597_1 1229758.C270_02385 5.2e-27 108.0 COG0745@1|root,COG0745@2|Bacteria,1TPWS@1239|Firmicutes,4H9KP@91061|Bacilli,4AWY9@81850|Leuconostocaceae 91061|Bacilli K Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain phoP - - ko:K07658 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_787877_2 1123237.Salmuc_00861 1.32e-24 101.0 COG4333@1|root,COG4333@2|Bacteria,1N19M@1224|Proteobacteria,2U5K3@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein conserved in bacteria - - - - - - - - - - - - DUF1643 k59_271070_1 1123393.KB891317_gene2287 1.19e-108 319.0 COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,2VH2K@28216|Betaproteobacteria,1KRAJ@119069|Hydrogenophilales 119069|Hydrogenophilales J Metallopeptidase family M24 map - 3.4.11.18 ko:K01265 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 k59_271070_2 1231391.AMZF01000014_gene2295 3.96e-25 106.0 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,2VI2G@28216|Betaproteobacteria,3T1S1@506|Alcaligenaceae 28216|Betaproteobacteria O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD - 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,GlnD_UR_UTase,HD,NTP_transf_2 k59_1044484_1 62928.azo0743 3.26e-64 210.0 COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,2VI41@28216|Betaproteobacteria,2KUFP@206389|Rhodocyclales 206389|Rhodocyclales I Catalyzes the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol clsB - - ko:K06131 ko00564,ko01100,map00564,map01100 - R07390 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2 k59_143026_1 1123487.KB892840_gene74 1.44e-91 276.0 COG1013@1|root,COG1013@2|Bacteria,1MUY9@1224|Proteobacteria,2VKQX@28216|Betaproteobacteria,2KVZU@206389|Rhodocyclales 206389|Rhodocyclales C Thiamine pyrophosphate enzyme, C-terminal TPP binding domain padI - 1.2.1.58 ko:K18356 ko00360,map00360 - R02450 RC00004,RC02860 br01601,ko00000,ko00001,ko01000 - - - Fer4_11,Fer4_6,TPP_enzyme_C k59_703048_1 76114.ebA903 1.31e-145 426.0 COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,2VI12@28216|Betaproteobacteria,2KUBW@206389|Rhodocyclales 206389|Rhodocyclales J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence rpsA - - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 k59_622378_1 864702.OsccyDRAFT_3316 4.98e-15 73.9 COG0205@1|root,COG0205@2|Bacteria,1G0N7@1117|Cyanobacteria,1H82M@1150|Oscillatoriales 1117|Cyanobacteria G Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis pfkA - 2.7.1.11,2.7.1.90 ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130 - R00756,R00764,R02073,R03236,R04779 RC00002,RC00017 ko00000,ko00001,ko01000 - - iJN678.pfkA PFK k59_622378_2 396588.Tgr7_3049 2.16e-17 75.9 COG5481@1|root,COG5481@2|Bacteria 2|Bacteria S small protein containing a coiled-coil domain MA20_03740 - - - - - - - - - - - DUF465 k59_68106_1 1169143.KB911036_gene4724 6.57e-68 217.0 COG0552@1|root,COG0552@2|Bacteria,1MUDU@1224|Proteobacteria,2VHK7@28216|Betaproteobacteria,1K038@119060|Burkholderiaceae 28216|Betaproteobacteria U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components ftsY - - ko:K03110 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2,3.A.5.7 - - SRP54,SRP54_N k59_68106_2 640081.Dsui_1023 5.49e-85 256.0 COG2884@1|root,COG2884@2|Bacteria,1MVQ4@1224|Proteobacteria,2VINI@28216|Betaproteobacteria,2KVKB@206389|Rhodocyclales 206389|Rhodocyclales D cell division ftsE - - ko:K09812 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - ABC_tran k59_1214599_1 159087.Daro_1732 9.27e-25 107.0 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,2VJMF@28216|Betaproteobacteria,2KV3S@206389|Rhodocyclales 206389|Rhodocyclales D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_274423_1 383372.Rcas_2457 9.2e-81 250.0 COG0673@1|root,COG0673@2|Bacteria,2G851@200795|Chloroflexi 200795|Chloroflexi S PFAM oxidoreductase domain protein - - - - - - - - - - - - GFO_IDH_MocA k59_1171881_2 290398.Csal_1825 1.85e-77 238.0 COG1028@1|root,COG1028@2|Bacteria,1MU5Y@1224|Proteobacteria,1RP7D@1236|Gammaproteobacteria,1XJWC@135619|Oceanospirillales 135619|Oceanospirillales IQ Dehydrogenase bdh - 1.1.1.30 ko:K00019 ko00072,ko00650,ko01100,map00072,map00650,map01100 M00088 R01361 RC00117 ko00000,ko00001,ko00002,ko01000 - - - adh_short_C2 k59_1001138_2 272624.lpg2483 0.000282 42.7 COG2128@1|root,COG2128@2|Bacteria,1RC52@1224|Proteobacteria,1S2A0@1236|Gammaproteobacteria,1JGNC@118969|Legionellales 118969|Legionellales O Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - - - - - - - - - - CMD k59_870843_1 67593.Physo110356 3.48e-34 134.0 COG1249@1|root,KOG1335@2759|Eukaryota,3Q8AM@4776|Peronosporales 4776|Peronosporales C FAD dependent oxidoreductase - - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim k59_1346672_1 693986.MOC_2838 6.77e-65 218.0 COG4670@1|root,COG4670@2|Bacteria,1MUJW@1224|Proteobacteria,2TRRK@28211|Alphaproteobacteria,1JR1Y@119045|Methylobacteriaceae 28211|Alphaproteobacteria I PFAM Coenzyme A transferase pct - 2.8.3.1 ko:K01026 ko00620,ko00640,ko00643,ko01100,ko01120,map00620,map00640,map00643,map01100,map01120 - R00928,R01449,R05508 RC00012,RC00014,RC00137 ko00000,ko00001,ko01000 - - - CoA_trans k59_146398_1 1254432.SCE1572_46360 6.68e-54 187.0 COG2433@1|root,COG2433@2|Bacteria,1RJ1Q@1224|Proteobacteria,43CJE@68525|delta/epsilon subdivisions,2X7TT@28221|Deltaproteobacteria,2Z3N4@29|Myxococcales 28221|Deltaproteobacteria S Transposase IS66 family - - - ko:K07484 - - - - ko00000 - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66 k59_146406_1 342610.Patl_3740 3.83e-14 76.6 COG3595@1|root,COG3595@2|Bacteria,1P19T@1224|Proteobacteria,1RRSR@1236|Gammaproteobacteria,2Q1KI@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria S Putative adhesin - - - - - - - - - - - - DUF4097 k59_1298879_1 1430440.MGMSRv2_2335 1.84e-87 271.0 COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2TQKF@28211|Alphaproteobacteria,2JUC0@204441|Rhodospirillales 204441|Rhodospirillales L Cytoplasmic - - - - - - - - - - - - rve k59_1001183_1 1245469.S58_70940 1.99e-66 214.0 COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,2TQSI@28211|Alphaproteobacteria,3JRWP@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate ispG GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 - - - GcpE k59_1257357_1 643867.Ftrac_2006 1.9e-17 89.4 COG0760@1|root,COG0760@2|Bacteria,4NDZZ@976|Bacteroidetes,47KBN@768503|Cytophagia 976|Bacteroidetes O peptidylprolyl isomerase ppiD - 5.2.1.8 ko:K01802,ko:K03770 - - - - ko00000,ko01000,ko03110 - - - Rotamase_2,Rotamase_3,SurA_N_2 k59_1257371_1 1163617.SCD_n01314 5.11e-54 189.0 COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,2VI7X@28216|Betaproteobacteria 28216|Betaproteobacteria NU general secretion pathway protein D gspD - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Secretin,Secretin_N k59_703171_1 760117.JN27_13385 3.14e-64 212.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,2VI4G@28216|Betaproteobacteria,47346@75682|Oxalobacteraceae 28216|Betaproteobacteria E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) leuA - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_23118_1 595536.ADVE02000001_gene1865 1.39e-45 162.0 COG3385@1|root,COG3385@2|Bacteria,1MWWJ@1224|Proteobacteria,2TQT5@28211|Alphaproteobacteria 28211|Alphaproteobacteria L transposase activity - - - - - - - - - - - - DDE_Tnp_1 k59_622527_1 1121013.P873_03040 2.14e-48 177.0 COG4262@1|root,COG4262@2|Bacteria,1QXYI@1224|Proteobacteria,1T3KR@1236|Gammaproteobacteria,1X8H2@135614|Xanthomonadales 135614|Xanthomonadales S Spermine/spermidine synthase domain - - - - - - - - - - - - Spermine_synth k59_792477_1 1500257.JQNM01000002_gene4482 0.000141 44.3 2DP88@1|root,330ZC@2|Bacteria,1N838@1224|Proteobacteria,2UISU@28211|Alphaproteobacteria,4BG83@82115|Rhizobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_745752_2 757424.Hsero_1612 1.77e-70 219.0 COG0714@1|root,COG0714@2|Bacteria,1MV5I@1224|Proteobacteria,2VH9H@28216|Betaproteobacteria,473K5@75682|Oxalobacteraceae 28216|Betaproteobacteria O AAA domain (Cdc48 subfamily) - - - - - - - - - - - - AAA,AAA_5 k59_104087_1 631362.Thi970DRAFT_02714 1.08e-89 275.0 COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,1T20Y@1236|Gammaproteobacteria 1236|Gammaproteobacteria C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol nqrB - 1.6.5.8 ko:K00347,ko:K03614 - - - - ko00000,ko01000 - - - NQR2_RnfD_RnfE k59_703205_1 1432055.GLUCORHAEAF1_02865 1.24e-22 100.0 COG2197@1|root,COG2197@2|Bacteria,1QWED@1224|Proteobacteria,2TWX4@28211|Alphaproteobacteria 28211|Alphaproteobacteria KT Taurine catabolism dioxygenase TauD, TfdA - - - - - - - - - - - - TauD k59_828005_1 1123367.C666_04180 1.72e-59 206.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,2VJ57@28216|Betaproteobacteria,2KUC6@206389|Rhodocyclales 206389|Rhodocyclales L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_274588_1 479434.Sthe_2985 6.39e-37 139.0 COG0168@1|root,COG0168@2|Bacteria,2G8FV@200795|Chloroflexi,27YUG@189775|Thermomicrobia 189775|Thermomicrobia P Cation transport protein - - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_274588_2 32042.PstZobell_06840 0.000591 42.0 COG0569@1|root,COG0569@2|Bacteria,1R7KM@1224|Proteobacteria,1S6QA@1236|Gammaproteobacteria,1Z0FE@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria P TrkA-N domain ktrA - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N k59_191577_1 189753.AXAS01000078_gene6582 2.3e-89 275.0 COG2072@1|root,COG2072@2|Bacteria,1MWPJ@1224|Proteobacteria,2TSQA@28211|Alphaproteobacteria,3JT1R@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P Pyridine nucleotide-disulphide oxidoreductase - - - ko:K07222 - - - - ko00000 - - - Pyr_redox_3 k59_1172058_1 706587.Desti_2760 5e-77 248.0 COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,42NGD@68525|delta/epsilon subdivisions,2WJDC@28221|Deltaproteobacteria,2MRBS@213462|Syntrophobacterales 28221|Deltaproteobacteria C TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M nuoM - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q5_N,Proton_antipo_M k59_490037_2 640081.Dsui_1041 1.16e-51 176.0 COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,2VI41@28216|Betaproteobacteria,2KUFP@206389|Rhodocyclales 206389|Rhodocyclales I Catalyzes the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol clsB - - ko:K06131 ko00564,ko01100,map00564,map01100 - R07390 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2 k59_404698_1 1229205.BUPH_08508 4e-45 155.0 COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,2VNSH@28216|Betaproteobacteria,1KGQD@119060|Burkholderiaceae 28216|Betaproteobacteria L Phage integrase, N-terminal SAM-like domain - - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_4,Phage_integrase k59_404698_2 697282.Mettu_0273 3.92e-97 296.0 COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,1RYPY@1236|Gammaproteobacteria,1XETG@135618|Methylococcales 1236|Gammaproteobacteria S PFAM Transposase, IS801 IS1294 - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_233738_1 1121013.P873_06145 1.96e-41 153.0 COG1668@1|root,COG1668@2|Bacteria,1NK4G@1224|Proteobacteria,1RMMK@1236|Gammaproteobacteria 1236|Gammaproteobacteria CP COG1668 ABC-type Na efflux pump, permease component natB - - ko:K09696 ko02010,ko02020,map02010,map02020 M00253 - - ko00000,ko00001,ko00002,ko02000 3.A.1.115 - - ABC2_membrane_2,ABC2_membrane_3 k59_233738_2 1278073.MYSTI_07425 6.32e-10 58.9 COG4555@1|root,COG4555@2|Bacteria,1QU2T@1224|Proteobacteria,43BX9@68525|delta/epsilon subdivisions,2X782@28221|Deltaproteobacteria 28221|Deltaproteobacteria CP ABC transporter natA - 3.6.3.7 ko:K09697 ko02010,ko02020,map02010,map02020 M00253 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.115 - - ABC_tran k59_1257518_1 999541.bgla_1g33230 3.49e-77 242.0 COG0126@1|root,COG0126@2|Bacteria,1MUNU@1224|Proteobacteria,2VHJK@28216|Betaproteobacteria,1K22I@119060|Burkholderiaceae 28216|Betaproteobacteria G Belongs to the phosphoglycerate kinase family pgk GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.2.3 ko:K00927 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01512 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGK k59_1049235_1 1300345.LF41_2063 8.96e-31 125.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1X3PH@135614|Xanthomonadales 135614|Xanthomonadales T GGDEF domain - - - - - - - - - - - - EAL,GGDEF,HAMP,PAS_3,PAS_9,Reg_prop,Y_Y_Y k59_1037145_2 204773.HEAR2845 5.49e-45 152.0 COG2928@1|root,COG2928@2|Bacteria,1MWT5@1224|Proteobacteria,2VH65@28216|Betaproteobacteria,4732X@75682|Oxalobacteraceae 28216|Betaproteobacteria S Protein of unknown function (DUF502) - - - - - - - - - - - - DUF502 k59_137829_1 640081.Dsui_2686 1.06e-34 133.0 COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,2VHTX@28216|Betaproteobacteria,2KV13@206389|Rhodocyclales 206389|Rhodocyclales M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamA - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_137829_2 76114.ebA5997 8.18e-52 170.0 COG2825@1|root,COG2825@2|Bacteria,1RD8X@1224|Proteobacteria,2VRZI@28216|Betaproteobacteria,2KWH8@206389|Rhodocyclales 206389|Rhodocyclales M Belongs to the skp family - - - ko:K06142 - - - - ko00000 - - - OmpH k59_1289635_1 1282876.BAOK01000001_gene2408 6.28e-42 144.0 COG0360@1|root,COG0360@2|Bacteria,1RH82@1224|Proteobacteria,2U767@28211|Alphaproteobacteria,4BQK0@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria J Binds together with S18 to 16S ribosomal RNA rpsF GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0097159,GO:1901363,GO:1990904 - ko:K02990 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S6 k59_1289635_2 1089552.KI911559_gene2822 6.82e-40 133.0 COG0238@1|root,COG0238@2|Bacteria,1MZ8U@1224|Proteobacteria,2UC13@28211|Alphaproteobacteria,2JT7Q@204441|Rhodospirillales 204441|Rhodospirillales J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit rpsR - - ko:K02963 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S18 k59_480172_1 411464.DESPIG_02881 5.56e-22 95.1 2C9JF@1|root,32RPD@2|Bacteria,1N8CG@1224|Proteobacteria,42REW@68525|delta/epsilon subdivisions,2WNQ1@28221|Deltaproteobacteria,2MB30@213115|Desulfovibrionales 28221|Deltaproteobacteria S ERF superfamily - - - - - - - - - - - - ERF k59_522867_1 1407650.BAUB01000022_gene2629 3.47e-65 218.0 COG1028@1|root,COG3347@1|root,COG1028@2|Bacteria,COG3347@2|Bacteria,1G0Q0@1117|Cyanobacteria,1H06P@1129|Synechococcus 1117|Cyanobacteria IQ Class II Aldolase and Adducin N-terminal domain - - - - - - - - - - - - Aldolase_II,adh_short,adh_short_C2 k59_95402_1 1156919.QWC_00345 4.69e-132 395.0 COG5476@1|root,COG5476@2|Bacteria,1MX4P@1224|Proteobacteria,2VNJ6@28216|Betaproteobacteria,3T6W6@506|Alcaligenaceae 28216|Betaproteobacteria E Involved in peptidolytic degradation of cyclic heptapeptide hepatotoxin microcystin (MC) - - - - - - - - - - - - DUF1485,MlrC_C k59_991674_1 1123367.C666_10805 1.62e-51 176.0 COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,2VI5Q@28216|Betaproteobacteria,2KUH4@206389|Rhodocyclales 206389|Rhodocyclales D Peptidoglycan polymerase that is essential for cell division ftsW - - ko:K03588 ko04112,map04112 - - - ko00000,ko00001,ko02000,ko03036 2.A.103.1 - - FTSW_RODA_SPOVE k59_13197_1 1230476.C207_00254 7.77e-71 231.0 COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2TQKQ@28211|Alphaproteobacteria,3JSS3@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E GMC oxidoreductase MA20_44990 - 1.1.99.1 ko:K00108 ko00260,ko01100,map00260,map01100 M00555 R01025 RC00087 ko00000,ko00001,ko00002,ko01000 - - - GMC_oxred_C,GMC_oxred_N k59_13197_2 331869.BAL199_24474 2.44e-125 369.0 COG0683@1|root,COG0683@2|Bacteria,1MWQB@1224|Proteobacteria,2U0KM@28211|Alphaproteobacteria,4BSBD@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E Receptor family ligand binding region - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_1118082_1 563192.HMPREF0179_02582 4.44e-43 161.0 COG0729@1|root,COG0729@2|Bacteria,1MUKM@1224|Proteobacteria,42MB2@68525|delta/epsilon subdivisions,2WJAF@28221|Deltaproteobacteria,2M7RN@213115|Desulfovibrionales 28221|Deltaproteobacteria M PFAM surface antigen (D15) - - - ko:K07277,ko:K07278 - - - - ko00000,ko02000,ko03029 1.B.33,1.B.33.2.4 - - Bac_surface_Ag,POTRA,POTRA_TamA_1 k59_394687_1 224719.Abm4_1731 3.55e-22 94.4 COG3273@1|root,arCOG01963@2157|Archaea,2XSXK@28890|Euryarchaeota 28890|Euryarchaeota P TrkA-C domain protein pchB - - - - - - - - - - - PhoU,TrkA_C k59_394687_2 694430.Natoc_0214 8.58e-06 48.5 COG3273@1|root,arCOG01963@2157|Archaea,2XSXK@28890|Euryarchaeota,23RY7@183963|Halobacteria 183963|Halobacteria P TrkA-C domain-containing protein pchB - - - - - - - - - - - PhoU,TrkA_C k59_949074_1 999541.bgla_1g02980 1.01e-52 169.0 COG0049@1|root,COG0049@2|Bacteria,1MXC8@1224|Proteobacteria,2VQ63@28216|Betaproteobacteria,1K1QQ@119060|Burkholderiaceae 28216|Betaproteobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA rpsG - - ko:K02992 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S7 k59_949074_2 882378.RBRH_01230 8.96e-61 191.0 COG0048@1|root,COG0048@2|Bacteria,1RCWY@1224|Proteobacteria,2VR2H@28216|Betaproteobacteria,1K79Y@119060|Burkholderiaceae 28216|Betaproteobacteria J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit rpsL - - ko:K02950 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosom_S12_S23 k59_354303_1 1121920.AUAU01000017_gene1239 2.08e-41 152.0 COG0281@1|root,COG0281@2|Bacteria,3Y43V@57723|Acidobacteria 57723|Acidobacteria C Malic enzyme, NAD binding domain - - 1.1.1.38 ko:K00027 ko00620,ko01200,ko02020,map00620,map01200,map02020 - R00214 RC00105 ko00000,ko00001,ko01000 - - - Malic_M,malic k59_862455_1 698761.RTCIAT899_CH14505 6.26e-103 305.0 COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1P76X@1224|Proteobacteria,2U16U@28211|Alphaproteobacteria,4BC2J@82115|Rhizobiaceae 28211|Alphaproteobacteria L Transposase and inactivated - - - ko:K07494 - - - - ko00000 - - - DDE_3 k59_137899_1 1336243.JAEA01000002_gene2757 7.11e-81 244.0 COG2128@1|root,COG2128@2|Bacteria,1MUDM@1224|Proteobacteria,2TTY5@28211|Alphaproteobacteria,1JTZJ@119045|Methylobacteriaceae 28211|Alphaproteobacteria S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - - - - - - - - - - CMD k59_184828_1 179408.Osc7112_5083 7.99e-94 296.0 COG3957@1|root,COG3957@2|Bacteria,1G0B2@1117|Cyanobacteria,1H7CT@1150|Oscillatoriales 1117|Cyanobacteria G D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase - - 4.1.2.22,4.1.2.9 ko:K01621 ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120 - R00761,R01621 RC00032,RC00226 ko00000,ko00001,ko01000 - - - XFP,XFP_C,XFP_N k59_358049_1 1384054.N790_13875 1.18e-18 91.3 COG0729@1|root,COG1752@1|root,COG0729@2|Bacteria,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,1RRSK@1236|Gammaproteobacteria,1X39X@135614|Xanthomonadales 135614|Xanthomonadales M Patatin-like phospholipase - - - ko:K07001 - - - - ko00000 - - - Bac_surface_Ag,Patatin k59_653462_2 1380391.JIAS01000003_gene1914 8.22e-58 186.0 COG0121@1|root,COG0121@2|Bacteria,1PX9W@1224|Proteobacteria,2U07B@28211|Alphaproteobacteria,2JRUG@204441|Rhodospirillales 204441|Rhodospirillales S Glutamine amidotransferases class-II - - - - - - - - - - - - GATase_4 k59_1165241_1 757424.Hsero_2566 1.14e-101 301.0 COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2VJ0Q@28216|Betaproteobacteria,475FM@75682|Oxalobacteraceae 28216|Betaproteobacteria E amino acid - - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_1165241_2 159087.Daro_0251 6.4e-31 117.0 COG0559@1|root,COG0559@2|Bacteria,1N54M@1224|Proteobacteria,2VIID@28216|Betaproteobacteria,2KVZ8@206389|Rhodocyclales 206389|Rhodocyclales U Belongs to the binding-protein-dependent transport system permease family - - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_16274_1 1380394.JADL01000011_gene4061 4.82e-89 270.0 COG0010@1|root,COG0010@2|Bacteria,1MVFH@1224|Proteobacteria,2TQSZ@28211|Alphaproteobacteria,2JQHR@204441|Rhodospirillales 204441|Rhodospirillales E COG0010 Arginase agmatinase formimionoglutamate hydrolase, arginase family - - 3.5.3.17 ko:K18459 - - - - ko00000,ko01000 - - - Arginase k59_1120652_1 977880.RALTA_A1838 6.48e-111 336.0 COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,2VH2W@28216|Betaproteobacteria,1JZU5@119060|Burkholderiaceae 28216|Betaproteobacteria T GTP-binding protein typA - - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 k59_1120652_2 338963.Pcar_0272 4.94e-65 212.0 COG1972@1|root,COG1972@2|Bacteria,1MXXX@1224|Proteobacteria,42PC9@68525|delta/epsilon subdivisions,2WKA4@28221|Deltaproteobacteria,43SZ4@69541|Desulfuromonadales 28221|Deltaproteobacteria F Na+ dependent nucleoside transporter C-terminus - - - ko:K03317 - - - - ko00000 2.A.41 - - Gate,Nucleos_tra2_C,Nucleos_tra2_N k59_865044_1 671143.DAMO_3173 3.86e-35 135.0 COG0001@1|root,COG0001@2|Bacteria,2NP0W@2323|unclassified Bacteria 2|Bacteria H Aminotransferase class-III - - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aldolase_II,Aminotran_3 k59_784356_1 1218075.BAYA01000001_gene425 1.72e-11 70.5 COG3064@1|root,COG3064@2|Bacteria,1R6JV@1224|Proteobacteria,2VZS5@28216|Betaproteobacteria,1KDT6@119060|Burkholderiaceae 28216|Betaproteobacteria M Membrane - - - - - - - - - - - - - k59_227205_1 331869.BAL199_08898 6.07e-72 231.0 COG2271@1|root,COG2271@2|Bacteria,1QTW2@1224|Proteobacteria,2U07Z@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Major Facilitator Superfamily MA20_02120 - - - - - - - - - - - MFS_1 k59_440634_1 633149.Bresu_0142 4.11e-28 107.0 COG0799@1|root,COG0799@2|Bacteria,1MZEF@1224|Proteobacteria,2UBSV@28211|Alphaproteobacteria,2KGTH@204458|Caulobacterales 204458|Caulobacterales J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation rsfS - - ko:K09710 - - - - ko00000,ko03009 - - - RsfS k59_227214_1 323848.Nmul_A2507 5.4e-50 167.0 COG3216@1|root,COG3216@2|Bacteria,1RGV6@1224|Proteobacteria,2VSHR@28216|Betaproteobacteria,3732Y@32003|Nitrosomonadales 28216|Betaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2062) - - - ko:K09928 - - - - ko00000 - - - DUF2062 k59_227214_2 265072.Mfla_2093 4.94e-12 67.8 COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1MUKF@1224|Proteobacteria,2VHKP@28216|Betaproteobacteria,2KMAI@206350|Nitrosomonadales 206350|Nitrosomonadales S DNA internalization-related competence protein ComEC Rec2 - - - ko:K02238 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - Competence,DUF4131,Lactamase_B k59_1292605_1 1131814.JAFO01000001_gene4433 1.68e-68 229.0 COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2TR7S@28211|Alphaproteobacteria,3F0PJ@335928|Xanthobacteraceae 28211|Alphaproteobacteria I Poly-beta-hydroxybutyrate polymerase N terminal phbC1 - - ko:K03821 ko00650,map00650 - R04254 RC00004 ko00000,ko00001,ko01000 - - - PHBC_N,PhaC_N k59_1292605_2 338969.Rfer_1769 2.99e-51 170.0 arCOG10456@1|root,2ZA6T@2|Bacteria,1R4VS@1224|Proteobacteria,2VQRB@28216|Betaproteobacteria,4AIFM@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_227237_1 76114.ebA3917 6.07e-91 280.0 COG1139@1|root,COG1139@2|Bacteria,1MV6J@1224|Proteobacteria,2VJ3Y@28216|Betaproteobacteria,2KU8D@206389|Rhodocyclales 206389|Rhodocyclales C Domain of unknown function (DUF3390) - - - ko:K18929 - - - - ko00000 - - - DUF3390,Fer4_8,LUD_dom k59_140588_1 596154.Alide2_1317 1.44e-52 176.0 COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,2VH51@28216|Betaproteobacteria,4AAWA@80864|Comamonadaceae 28216|Betaproteobacteria O Peptidase U32 yhbU - - ko:K08303 ko05120,map05120 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_U32 k59_140588_2 1198452.Jab_2c11000 1.08e-20 88.6 COG0826@1|root,COG0826@2|Bacteria,1MWFW@1224|Proteobacteria,2VISF@28216|Betaproteobacteria,472JT@75682|Oxalobacteraceae 28216|Betaproteobacteria O Peptidase family U32 - - - - - - - - - - - - Peptidase_U32 k59_140593_1 565045.NOR51B_957 6.73e-56 186.0 COG2370@1|root,COG2370@2|Bacteria,1MV6Z@1224|Proteobacteria,1SNUJ@1236|Gammaproteobacteria,1JA38@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O HupE / UreJ protein - - - - - - - - - - - - HupE_UreJ_2 k59_227251_1 2340.JV46_12300 1.85e-37 140.0 COG4579@1|root,COG4579@2|Bacteria,1MVRB@1224|Proteobacteria,1RMC2@1236|Gammaproteobacteria,1J4W7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation aceK GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0004721,GO:0004722,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006081,GO:0006082,GO:0006091,GO:0006097,GO:0006099,GO:0006101,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008772,GO:0009060,GO:0009987,GO:0015980,GO:0016208,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016787,GO:0016788,GO:0016791,GO:0016999,GO:0017076,GO:0017144,GO:0018105,GO:0018193,GO:0018209,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0035639,GO:0036094,GO:0036211,GO:0042578,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044260,GO:0044262,GO:0044267,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046487,GO:0050790,GO:0055114,GO:0065007,GO:0065009,GO:0070262,GO:0071704,GO:0072350,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 2.7.11.5 ko:K00906 - - - - ko00000,ko01000 - - - AceK k59_227251_2 1429916.X566_22740 9.36e-17 82.0 COG0111@1|root,COG0111@2|Bacteria,1MW1U@1224|Proteobacteria,2TSUU@28211|Alphaproteobacteria,3JXSQ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria EH D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain - - - - - - - - - - - - 2-Hacid_dh,2-Hacid_dh_C k59_994698_1 401526.TcarDRAFT_1018 1.63e-50 169.0 COG0024@1|root,COG0024@2|Bacteria,1TQC1@1239|Firmicutes,4H2VZ@909932|Negativicutes 909932|Negativicutes E Methionine aminopeptidase map - 3.4.11.18 ko:K01265 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 k59_822302_1 436308.Nmar_1627 2.74e-157 466.0 COG0209@1|root,arCOG03713@1|root,arCOG03713@2157|Archaea,arCOG04276@2157|Archaea,41SAH@651137|Thaumarchaeota 651137|Thaumarchaeota F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN k59_909623_2 448385.sce2211 7.23e-06 53.5 COG0625@1|root,COG0625@2|Bacteria 2|Bacteria O glutathione transferase activity - - - - - - - - - - - - GST_N_3 k59_909623_3 62928.azo3488 1.3e-11 64.3 COG1526@1|root,COG1526@2|Bacteria,1MY28@1224|Proteobacteria,2VK94@28216|Betaproteobacteria,2KV23@206389|Rhodocyclales 206389|Rhodocyclales C Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH fdhD - - ko:K02379 - - - - ko00000 - - - FdhD-NarQ k59_822314_1 376733.IT41_19990 8.55e-107 311.0 COG3335@1|root,COG3335@2|Bacteria,1P76X@1224|Proteobacteria,2U16U@28211|Alphaproteobacteria,2PXYA@265|Paracoccus 28211|Alphaproteobacteria L DDE superfamily endonuclease - - - - - - - - - - - - DDE_3 k59_1083434_1 205922.Pfl01_5427 8.64e-27 102.0 COG0509@1|root,COG0509@2|Bacteria,1RGV7@1224|Proteobacteria,1S656@1236|Gammaproteobacteria,1YQH5@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria E The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein gcvH GO:0001505,GO:0003674,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008289,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0017144,GO:0019464,GO:0019752,GO:0031405,GO:0031406,GO:0033293,GO:0036094,GO:0042133,GO:0042135,GO:0042737,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0048037,GO:0050662,GO:0065007,GO:0065008,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1901681 - ko:K02437 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221 RC00022,RC02834 ko00000,ko00001,ko00002 - - iE2348C_1286.E2348C_3156,iPC815.YPO0906 GCV_H k59_1083434_2 420662.Mpe_A1431 1.26e-62 216.0 COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,1MUDP@1224|Proteobacteria,2VHQ6@28216|Betaproteobacteria,1KJKP@119065|unclassified Burkholderiales 28216|Betaproteobacteria E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvP - 1.4.4.2 ko:K00281 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko00002,ko01000 - - - GDC-P k59_822321_1 1168059.KB899087_gene3024 2.98e-71 233.0 COG0531@1|root,COG0531@2|Bacteria,1MXNJ@1224|Proteobacteria 1224|Proteobacteria E amino acid frlA GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006040,GO:0006082,GO:0006520,GO:0006807,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008152,GO:0008509,GO:0008514,GO:0009056,GO:0009063,GO:0009987,GO:0015075,GO:0015171,GO:0015179,GO:0015291,GO:0015297,GO:0015318,GO:0015711,GO:0015807,GO:0015849,GO:0016020,GO:0016021,GO:0016054,GO:0019752,GO:0022804,GO:0022857,GO:0030389,GO:0030392,GO:0030393,GO:0031224,GO:0031226,GO:0034220,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044425,GO:0044459,GO:0044464,GO:0046348,GO:0046395,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0098656,GO:1901135,GO:1901136,GO:1901281,GO:1901564,GO:1901565,GO:1901575,GO:1902475,GO:1903825,GO:1905039 - ko:K03294,ko:K19540 - - - - ko00000,ko02000 2.A.3.2,2.A.3.8.17 - iAF1260.b3370,iB21_1397.B21_03173,iBWG_1329.BWG_3062,iEC042_1314.EC042_3632,iEC55989_1330.EC55989_3776,iECBD_1354.ECBD_0378,iECB_1328.ECB_03221,iECDH10B_1368.ECDH10B_3546,iECDH1ME8569_1439.ECDH1ME8569_3250,iECD_1391.ECD_03221,iECIAI1_1343.ECIAI1_3509,iECO111_1330.ECO111_4180,iECO26_1355.ECO26_4459,iETEC_1333.ETEC_3621,iEcDH1_1363.EcDH1_0342,iJO1366.b3370,iSSON_1240.SSON_3502,iUMNK88_1353.UMNK88_4136,iY75_1357.Y75_RS20365 AA_permease_2 k59_784494_1 1101192.KB910516_gene2989 4.48e-25 100.0 COG3415@1|root,COG3415@2|Bacteria,1NA4C@1224|Proteobacteria,2UIPD@28211|Alphaproteobacteria,1JZAN@119045|Methylobacteriaceae 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - HTH_23 k59_784494_2 1547437.LL06_26180 2.2e-104 305.0 COG3335@1|root,COG3335@2|Bacteria,1P76X@1224|Proteobacteria,2VBH8@28211|Alphaproteobacteria,43P72@69277|Phyllobacteriaceae 28211|Alphaproteobacteria L DDE superfamily endonuclease - - - - - - - - - - - - DDE_3 k59_1041075_1 768066.HELO_3847 1.63e-80 249.0 COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,1RNJ1@1236|Gammaproteobacteria,1XJ29@135619|Oceanospirillales 135619|Oceanospirillales P transporter, permease oppB - - ko:K02033,ko:K15581 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - BPD_transp_1 k59_316263_1 1297570.MESS4_30020 7.63e-15 77.8 COG1028@1|root,COG1028@2|Bacteria,1R3U8@1224|Proteobacteria,2U1SI@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ KR domain - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_140666_1 1229909.NSED_02485 3.22e-25 103.0 COG0719@1|root,arCOG01715@2157|Archaea,41S7W@651137|Thaumarchaeota 651137|Thaumarchaeota O FeS assembly protein SufD - - - ko:K09014,ko:K09015 - - - - ko00000 - - - UPF0051 k59_140666_2 1229909.NSED_02480 1.02e-59 196.0 COG0719@1|root,arCOG01715@2157|Archaea,41S5W@651137|Thaumarchaeota 651137|Thaumarchaeota O FeS assembly protein SufB - - - ko:K09014 - - - - ko00000 - - - UPF0051 k59_739163_1 585.DR95_3539 8.4e-06 52.8 COG0730@1|root,COG0730@2|Bacteria,1MX4T@1224|Proteobacteria,1S132@1236|Gammaproteobacteria,3Z379@583|Proteus 1236|Gammaproteobacteria S Sulfite exporter TauE/SafE - - - ko:K07090 - - - - ko00000 - - - TauE k59_567015_2 395493.BegalDRAFT_1783 1.12e-23 97.1 COG3198@1|root,COG3198@2|Bacteria,1N75J@1224|Proteobacteria,1SC87@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria ccoH - - ko:K09926 - - - - ko00000 - - - FixH k59_614671_1 1121927.GOHSU_28_00450 8.11e-78 243.0 COG1960@1|root,COG1960@2|Bacteria,2GM3V@201174|Actinobacteria,4GAET@85026|Gordoniaceae 201174|Actinobacteria I Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_316297_1 1274524.BSONL12_06623 2.61e-39 144.0 COG2124@1|root,COG2124@2|Bacteria,1TPWZ@1239|Firmicutes,4HAGS@91061|Bacilli,1ZC1Y@1386|Bacillus 91061|Bacilli C Cytochrome P450 yjiB GO:0003674,GO:0003824,GO:0004497,GO:0006066,GO:0006629,GO:0006706,GO:0006707,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0008395,GO:0009056,GO:0016042,GO:0016125,GO:0016127,GO:0016491,GO:0016705,GO:0016709,GO:0036199,GO:0044238,GO:0044281,GO:0044282,GO:0046164,GO:0055114,GO:0071704,GO:1901360,GO:1901361,GO:1901575,GO:1901615,GO:1901616,GO:1902652 - - - - - - - - - - p450 k59_1083528_2 713587.THITH_04050 1.23e-123 368.0 COG0007@1|root,COG1648@1|root,COG0007@2|Bacteria,COG1648@2|Bacteria,1MUI0@1224|Proteobacteria,1RM9V@1236|Gammaproteobacteria,1WW79@135613|Chromatiales 135613|Chromatiales H Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme cysG - 1.3.1.76,2.1.1.107,4.99.1.4 ko:K02302 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02864,R03194,R03947 RC00003,RC00871,RC01012,RC01034 ko00000,ko00001,ko00002,ko01000 - - - CysG_dimeriser,NAD_binding_7,Sirohm_synth_M,TP_methylase k59_397946_1 59538.XP_005985002.1 9.72e-41 141.0 COG0094@1|root,KOG0398@2759|Eukaryota,38D2V@33154|Opisthokonta,3BZST@33208|Metazoa 33208|Metazoa J Ribosomal protein L5 - - - - - - - - - - - - Ribosomal_L5,Ribosomal_L5_C,ribosomal_L24 k59_397946_2 557598.LHK_00266 2.71e-35 123.0 COG0199@1|root,COG0199@2|Bacteria,1MZDT@1224|Proteobacteria,2VSVX@28216|Betaproteobacteria,2KRHM@206351|Neisseriales 206351|Neisseriales J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site rpsN - - ko:K02954 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S14 k59_397946_3 1286093.C266_01794 1.84e-15 71.2 COG0096@1|root,COG0096@2|Bacteria,1RDG3@1224|Proteobacteria,2VRBD@28216|Betaproteobacteria,1K77S@119060|Burkholderiaceae 28216|Betaproteobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit rpsH - - ko:K02994 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S8 k59_696627_1 583345.Mmol_0474 1.77e-33 129.0 COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,2VP2B@28216|Betaproteobacteria,2KNNY@206350|Nitrosomonadales 206350|Nitrosomonadales V ABC transporter transmembrane region - - - ko:K11004 ko02010,ko03070,ko05133,map02010,map03070,map05133 M00325,M00575 - - ko00000,ko00001,ko00002,ko02000,ko02044 3.A.1.109.1,3.A.1.109.2 - - ABC_membrane,ABC_tran k59_1165457_2 153948.NAL212_0605 3.97e-48 174.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,2VI7M@28216|Betaproteobacteria,372K8@32003|Nitrosomonadales 28216|Betaproteobacteria L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_994831_1 1100720.ALKN01000045_gene406 3.08e-11 66.6 COG0839@1|root,COG0839@2|Bacteria,1MWJV@1224|Proteobacteria,2VJ4G@28216|Betaproteobacteria,4AB48@80864|Comamonadaceae 28216|Betaproteobacteria C Belongs to the complex I subunit 6 family nuoJ - 1.6.5.3 ko:K00339 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q3 k59_865243_1 1122975.AQVC01000020_gene71 3.03e-13 69.7 COG1576@1|root,COG1576@2|Bacteria,4NMFP@976|Bacteroidetes,2FN6G@200643|Bacteroidia,22XQY@171551|Porphyromonadaceae 976|Bacteroidetes J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA rlmH - 2.1.1.177 ko:K00783 - - - - ko00000,ko01000,ko03009 - - - SPOUT_MTase k59_865243_2 1385515.N791_04915 3.83e-13 66.6 COG0799@1|root,COG0799@2|Bacteria,1MZEF@1224|Proteobacteria,1S8W3@1236|Gammaproteobacteria,1X6H0@135614|Xanthomonadales 135614|Xanthomonadales J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation rsfS - - ko:K09710 - - - - ko00000,ko03009 - - - RsfS k59_358349_1 1038862.KB893840_gene1110 1.52e-80 266.0 COG2304@1|root,COG2304@2|Bacteria,1MW8K@1224|Proteobacteria,2TV9Y@28211|Alphaproteobacteria,3JSX0@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Vault protein inter-alpha-trypsin domain - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VIT,VWA_3 k59_739258_1 1123367.C666_08615 1.97e-126 375.0 COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,2VI3M@28216|Betaproteobacteria,2KVC9@206389|Rhodocyclales 206389|Rhodocyclales E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine lysA - 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_526188_1 1244869.H261_23172 1.53e-79 244.0 COG3677@1|root,COG3677@2|Bacteria,1R97R@1224|Proteobacteria,2U3R3@28211|Alphaproteobacteria,2JU7C@204441|Rhodospirillales 204441|Rhodospirillales L Transposase zinc-ribbon domain - - - - - - - - - - - - DDE_Tnp_IS1595,Zn_Tnp_IS1595 k59_483507_1 379066.GAU_2569 7.11e-93 283.0 COG2805@1|root,COG2805@2|Bacteria,1ZSQE@142182|Gemmatimonadetes 142182|Gemmatimonadetes NU Type II/IV secretion system protein - - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_483507_2 379066.GAU_2570 2.65e-07 51.6 COG2804@1|root,COG2804@2|Bacteria,1ZSSN@142182|Gemmatimonadetes 142182|Gemmatimonadetes NU Type II secretion system (T2SS), protein E, N-terminal domain - - - ko:K02652 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE,T2SSE_N k59_316437_1 795359.TOPB45_0383 1.13e-40 142.0 COG3945@1|root,COG3945@2|Bacteria 2|Bacteria P hemerythrin HHE cation binding domain - - - - - - - - - - - - Hemerythrin k59_16564_1 639283.Snov_0218 1.07e-109 324.0 COG0726@1|root,COG0726@2|Bacteria,1MV3V@1224|Proteobacteria,2TR0I@28211|Alphaproteobacteria,3F0MK@335928|Xanthobacteraceae 28211|Alphaproteobacteria G Polysaccharide deacetylase - - - - - - - - - - - - Polysacc_deac_1 k59_1208227_1 1123371.ATXH01000018_gene1360 2.66e-11 60.8 COG2963@1|root,COG2963@2|Bacteria 2|Bacteria L transposase activity - - - ko:K07483,ko:K07497 - - - - ko00000 - - - HTH_28,HTH_Tnp_1 k59_1165552_2 1121937.AUHJ01000005_gene2213 7.17e-22 95.9 COG3930@1|root,COG3930@2|Bacteria,1PYFH@1224|Proteobacteria,1RP1J@1236|Gammaproteobacteria,466YV@72275|Alteromonadaceae 1236|Gammaproteobacteria S DUF1704 IV02_27630 - - - - - - - - - - - DUF1704 k59_994929_1 1159870.KB907784_gene934 5.15e-44 160.0 COG0654@1|root,COG0654@2|Bacteria,1MUN4@1224|Proteobacteria,2VI73@28216|Betaproteobacteria,3T31T@506|Alcaligenaceae 28216|Betaproteobacteria CH 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases - - 1.14.13.127 ko:K05712 ko00360,ko01120,ko01220,map00360,map01120,map01220 M00545 R06786,R06787 RC00236 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_3 k59_945087_1 592029.DDD_1593 8.71e-10 64.3 COG0577@1|root,COG0577@2|Bacteria,4NEBD@976|Bacteroidetes,1HY2A@117743|Flavobacteriia,3HJ7A@363408|Nonlabens 976|Bacteroidetes V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_605921_1 671143.DAMO_2945 8.48e-78 254.0 COG0188@1|root,COG0188@2|Bacteria,2NNNR@2323|unclassified Bacteria 2|Bacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k59_1158291_1 1124780.ANNU01000032_gene1229 8.28e-09 61.6 COG2304@1|root,COG2304@2|Bacteria,4NF7Y@976|Bacteroidetes,47NJQ@768503|Cytophagia 976|Bacteroidetes S PFAM von Willebrand factor type A batB - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - BatA,VWA,VWA_2 k59_518978_1 522306.CAP2UW1_3465 9.62e-57 185.0 COG1309@1|root,COG1309@2|Bacteria,1RDIM@1224|Proteobacteria,2VJQ5@28216|Betaproteobacteria 28216|Betaproteobacteria K Transcriptional regulator - - - - - - - - - - - - TetR_N k59_394750_1 132113.XP_003493260.1 2.96e-26 106.0 2CMNT@1|root,2QR3D@2759|Eukaryota,39UHX@33154|Opisthokonta,3B9U3@33208|Metazoa,3D2YM@33213|Bilateria,4201I@6656|Arthropoda,3SMSN@50557|Insecta,46JE1@7399|Hymenoptera 33208|Metazoa G N-acetylmuramoyl-L-alanine amidase PGRPLB GO:0000270,GO:0002376,GO:0002682,GO:0002683,GO:0002831,GO:0002832,GO:0003674,GO:0003824,GO:0004040,GO:0005488,GO:0005515,GO:0005539,GO:0005575,GO:0005576,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0006950,GO:0006952,GO:0006955,GO:0008150,GO:0008152,GO:0008745,GO:0009056,GO:0009057,GO:0009253,GO:0009605,GO:0009607,GO:0009617,GO:0009966,GO:0009968,GO:0010646,GO:0010648,GO:0016787,GO:0016810,GO:0016811,GO:0023051,GO:0023057,GO:0030203,GO:0031347,GO:0031348,GO:0032101,GO:0032102,GO:0042742,GO:0042834,GO:0043170,GO:0043207,GO:0043900,GO:0043901,GO:0045087,GO:0045088,GO:0045824,GO:0048519,GO:0048523,GO:0048583,GO:0048585,GO:0050776,GO:0050777,GO:0050789,GO:0050794,GO:0050830,GO:0050896,GO:0051704,GO:0051707,GO:0061058,GO:0061060,GO:0061783,GO:0065007,GO:0071704,GO:0080134,GO:0097367,GO:0098542,GO:1900424,GO:1900425,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575 - ko:K01446 - - R04112 RC00064,RC00141 ko00000 - - - Amidase_2 k59_224333_1 580332.Slit_0629 5.55e-40 135.0 COG0139@1|root,COG0139@2|Bacteria,1MW67@1224|Proteobacteria,2VR9B@28216|Betaproteobacteria,44VV6@713636|Nitrosomonadales 28216|Betaproteobacteria E Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP hisI - 3.5.4.19,3.6.1.31 ko:K01496,ko:K11755 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04035,R04037 RC00002,RC01055 ko00000,ko00001,ko00002,ko01000 - - - PRA-CH k59_224333_2 34007.IT40_01365 1.39e-56 183.0 COG0107@1|root,COG0107@2|Bacteria,1MUS0@1224|Proteobacteria,2TQXD@28211|Alphaproteobacteria,2PUYQ@265|Paracoccus 28211|Alphaproteobacteria E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit hisF GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 - ko:K02500 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth k59_819725_2 1121937.AUHJ01000008_gene2015 3.87e-22 92.4 COG1794@1|root,COG1794@2|Bacteria,1MV03@1224|Proteobacteria,1RMHT@1236|Gammaproteobacteria,465HQ@72275|Alteromonadaceae 1236|Gammaproteobacteria M aspartate racemase - - 5.1.1.13 ko:K01779 ko00250,ko01054,map00250,map01054 - R00491 RC00302 ko00000,ko00001,ko01000 - - - Asp_Glu_race k59_95514_1 1236959.BAMT01000001_gene1342 1.76e-08 52.8 COG0640@1|root,COG0640@2|Bacteria,1MZAU@1224|Proteobacteria,2VTXZ@28216|Betaproteobacteria,2KMZQ@206350|Nitrosomonadales 206350|Nitrosomonadales K Transcriptional regulator, ArsR family - - - ko:K03892 - - - - ko00000,ko03000 - - - HTH_20 k59_95514_2 292415.Tbd_1135 4.31e-41 148.0 COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,2VI3U@28216|Betaproteobacteria,1KRIN@119069|Hydrogenophilales 119069|Hydrogenophilales G Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III - - 5.4.2.10 ko:K03431 ko00520,ko01100,ko01130,map00520,map01100,map01130 - R02060 RC00408 ko00000,ko00001,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_991794_1 635013.TherJR_0997 1.77e-63 219.0 COG0395@1|root,COG5001@1|root,COG5002@1|root,COG0395@2|Bacteria,COG5001@2|Bacteria,COG5002@2|Bacteria,1TP8V@1239|Firmicutes,247PX@186801|Clostridia,26021@186807|Peptococcaceae 186801|Clostridia T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_8,PAS_9 k59_523007_2 663610.JQKO01000008_gene192 1.54e-52 182.0 COG1559@1|root,COG1559@2|Bacteria,1MUQF@1224|Proteobacteria,2TR89@28211|Alphaproteobacteria,3N9XJ@45404|Beijerinckiaceae 28211|Alphaproteobacteria S Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation mltG - - ko:K07082 - - - - ko00000 - - - YceG k59_1118180_1 1131814.JAFO01000001_gene4685 4.75e-60 203.0 COG1053@1|root,COG1053@2|Bacteria,1MURY@1224|Proteobacteria,2TSRQ@28211|Alphaproteobacteria,3F1U8@335928|Xanthobacteraceae 28211|Alphaproteobacteria C PFAM fumarate reductase succinate dehydrogenase flavoprotein domain protein - - - - - - - - - - - - FAD_binding_2 k59_1162346_2 207954.MED92_16570 4.13e-42 147.0 COG0639@1|root,COG0639@2|Bacteria,1MV10@1224|Proteobacteria,1RPUJ@1236|Gammaproteobacteria,1XH8Y@135619|Oceanospirillales 135619|Oceanospirillales T Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP apaH - 3.6.1.41 ko:K01525 ko00230,map00230 - R00125 RC00002 ko00000,ko00001,ko01000 - - - Metallophos k59_480336_1 640081.Dsui_3398 2.01e-104 315.0 COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,2VI0E@28216|Betaproteobacteria,2KVNH@206389|Rhodocyclales 206389|Rhodocyclales L PFAM Integrase core domain - - - - - - - - - - - - HTH_38,rve k59_312593_1 1165096.ARWF01000001_gene2252 2.07e-80 253.0 COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,2VH7C@28216|Betaproteobacteria,2KKB0@206350|Nitrosomonadales 206350|Nitrosomonadales M TIGRFAM lipoprotein releasing system, transmembrane protein, LolC E family - - - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD k59_780753_2 314278.NB231_00255 2.64e-63 211.0 COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,1RN7H@1236|Gammaproteobacteria,1X0IX@135613|Chromatiales 135613|Chromatiales S PFAM peptidase S15 - - - ko:K06978 - - - - ko00000 - - - PepX_C,Peptidase_S15 k59_1334838_1 1232683.ADIMK_0488 6.47e-69 223.0 COG0464@1|root,COG0464@2|Bacteria,1MXFG@1224|Proteobacteria,1RZBX@1236|Gammaproteobacteria,469JC@72275|Alteromonadaceae 1236|Gammaproteobacteria O ATPases associated with a variety of cellular activities - - - - - - - - - - - - - k59_819787_1 247634.GPB2148_2697 1.44e-49 174.0 COG0477@1|root,COG2814@2|Bacteria,1MVKJ@1224|Proteobacteria,1RMHJ@1236|Gammaproteobacteria,1J8M0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family - - - ko:K05548 - - - - ko00000,ko02000 2.A.1.15 - - Sugar_tr k59_394871_1 1134474.O59_003510 9.97e-19 86.3 COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,1S5PP@1236|Gammaproteobacteria,1FGCV@10|Cellvibrio 1236|Gammaproteobacteria K Bacterial regulatory proteins, crp family - - - ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - Crp,HTH_Crp_2,cNMP_binding k59_13390_1 1265502.KB905930_gene1557 2.18e-08 51.6 COG0238@1|root,COG0238@2|Bacteria,1MZ8U@1224|Proteobacteria,2VTWT@28216|Betaproteobacteria,4AEBR@80864|Comamonadaceae 28216|Betaproteobacteria J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit rpsR - - ko:K02963 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S18 k59_13390_2 948106.AWZT01000002_gene6284 5.67e-62 194.0 COG0359@1|root,COG0359@2|Bacteria,1RD0R@1224|Proteobacteria,2VR40@28216|Betaproteobacteria,1K721@119060|Burkholderiaceae 28216|Betaproteobacteria J binds to the 23S rRNA rplI - - ko:K02939 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L9_C,Ribosomal_L9_N k59_906697_1 1238182.C882_0009 1.84e-76 243.0 COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,2TRFV@28211|Alphaproteobacteria,2JQBA@204441|Rhodospirillales 204441|Rhodospirillales G Belongs to the pyruvate kinase family ttuE - 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PK,PK_C k59_1247809_2 1205680.CAKO01000040_gene719 2.58e-10 63.2 COG0730@1|root,COG0730@2|Bacteria,1MWAN@1224|Proteobacteria,2TS4X@28211|Alphaproteobacteria,2JSQQ@204441|Rhodospirillales 204441|Rhodospirillales S Sulfite exporter TauE/SafE - - - ko:K07090 - - - - ko00000 - - - TauE k59_437879_1 331869.BAL199_27166 3.47e-82 254.0 COG0596@1|root,COG0596@2|Bacteria,1NJ2B@1224|Proteobacteria,2TR54@28211|Alphaproteobacteria 28211|Alphaproteobacteria S alpha/beta hydrolase fold - - - - - - - - - - - - Abhydrolase_1 k59_523119_2 1041139.KB902624_gene5769 1.86e-22 94.7 COG4828@1|root,COG4828@2|Bacteria,1N984@1224|Proteobacteria,2UBT7@28211|Alphaproteobacteria,4BGWZ@82115|Rhizobiaceae 28211|Alphaproteobacteria S Protein of unknown function (DUF1622) - - - - - - - - - - - - DUF1622 k59_95640_2 375286.mma_0198 4.32e-33 120.0 COG2891@1|root,COG2891@2|Bacteria,1RBNF@1224|Proteobacteria,2VQQ3@28216|Betaproteobacteria,47417@75682|Oxalobacteraceae 28216|Betaproteobacteria M rod shape-determining protein MreD mreD - - ko:K03571 - - - - ko00000,ko03036 9.B.157.1 - - MreD k59_1334946_1 1500894.JQNN01000001_gene2340 4.68e-133 390.0 COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,2VHSH@28216|Betaproteobacteria,472YE@75682|Oxalobacteraceae 28216|Betaproteobacteria E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuC - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase k59_312773_1 1458275.AZ34_07995 1.06e-90 293.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,2VI4A@28216|Betaproteobacteria,4ABM3@80864|Comamonadaceae 28216|Betaproteobacteria F Belongs to the CarB family carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_1289919_1 935840.JAEQ01000005_gene1199 5.18e-129 384.0 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,2TSCY@28211|Alphaproteobacteria,43IPA@69277|Phyllobacteriaceae 28211|Alphaproteobacteria E Asparagine synthase asnO - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_95686_1 1437824.BN940_11181 4.27e-19 85.5 COG1448@1|root,COG1448@2|Bacteria,1MUT0@1224|Proteobacteria,2VHNH@28216|Betaproteobacteria,3T2N1@506|Alcaligenaceae 28216|Betaproteobacteria E Aminotransferase tyrB - 2.6.1.57 ko:K00832 ko00270,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01230,map00270,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01230 M00024,M00025,M00034,M00040 R00694,R00734,R01731,R07396,R10845 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_1037609_1 1454004.AW11_02628 9.85e-104 314.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,2VI3N@28216|Betaproteobacteria,1KPMZ@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria J Translation, ribosomal structure and biogenesis cafA - - ko:K08301 - - - - ko00000,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_949388_2 519989.ECTPHS_00829 2.43e-25 108.0 COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,1RMH7@1236|Gammaproteobacteria,1X01F@135613|Chromatiales 135613|Chromatiales S TRAP transporter, 4TM 12TM fusion protein - - - - - - - - - - - - DctM k59_1247915_2 289377.HL41_08835 5.37e-16 75.5 COG1051@1|root,COG1051@2|Bacteria,2GHWZ@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria F NUDIX domain - - 3.6.1.55 ko:K03574 - - - - ko00000,ko01000,ko03400 - - - NUDIX k59_650830_2 160488.PP_1037 3.15e-23 100.0 COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,1RMRN@1236|Gammaproteobacteria,1YVXW@136845|Pseudomonas putida group 1236|Gammaproteobacteria F Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate purL GO:0000166,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006520,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009064,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016874,GO:0016879,GO:0016884,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - iECH74115_1262.ECH74115_3792,iECO111_1330.ECO111_3283,iECSP_1301.ECSP_3501,iECs_1301.ECs3423,iG2583_1286.G2583_3088,iJN746.PP_1037,ic_1306.c3080 AIRS_C,GATase_5 k59_224598_1 148960.XP_006956891.1 7.24e-08 54.3 COG2110@1|root,KOG2633@2759|Eukaryota,38JYP@33154|Opisthokonta,3NY56@4751|Fungi,3V17E@5204|Basidiomycota 4751|Fungi BK a1pp-domain-containing protein - - - - - - - - - - - - Macro k59_224598_2 1380393.JHVP01000003_gene804 2.52e-13 74.7 COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria 201174|Actinobacteria T signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - - - - - - - - - - EAL,GGDEF k59_906842_1 631362.Thi970DRAFT_02306 1.15e-69 225.0 COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,1RN1Y@1236|Gammaproteobacteria,1WWI5@135613|Chromatiales 135613|Chromatiales H Belongs to the anaerobic coproporphyrinogen-III oxidase family - - - - - - - - - - - - HemN_C,Radical_SAM k59_819989_1 358220.C380_17375 9e-95 286.0 COG0559@1|root,COG0559@2|Bacteria,1N5XH@1224|Proteobacteria,2VHAJ@28216|Betaproteobacteria,4AB5H@80864|Comamonadaceae 28216|Betaproteobacteria E Belongs to the binding-protein-dependent transport system permease family - - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_395132_1 1219031.BBJR01000050_gene1614 7.92e-20 89.0 COG0631@1|root,COG0631@2|Bacteria,1MVE7@1224|Proteobacteria,2VIAV@28216|Betaproteobacteria,4A9Q3@80864|Comamonadaceae 28216|Betaproteobacteria T protein phosphatase 2C domain protein pphA - 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C,PP2C_2 k59_395132_2 760117.JN27_15330 3.66e-47 162.0 COG0515@1|root,COG0515@2|Bacteria,1PJRR@1224|Proteobacteria,2VHMW@28216|Betaproteobacteria,473V0@75682|Oxalobacteraceae 28216|Betaproteobacteria KLT Protein tyrosine kinase spkD - - - - - - - - - - - Pkinase k59_312998_1 1454004.AW11_02472 1.39e-93 290.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VJ5E@28216|Betaproteobacteria,1KQBH@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria I AMP-binding enzyme bclA_2 - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_693861_2 1280950.HJO_14081 1.11e-53 182.0 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2TQN9@28211|Alphaproteobacteria,43WT1@69657|Hyphomonadaceae 28211|Alphaproteobacteria E Threonine dehydratase ilvA - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - ACT,ACT_4,PALP k59_1335227_1 55601.VANGNB10_cI2081c 1.27e-58 196.0 COG1726@1|root,COG1726@2|Bacteria,1MU36@1224|Proteobacteria,1RPU1@1236|Gammaproteobacteria,1XTB1@135623|Vibrionales 135623|Vibrionales C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol nqrA GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008137,GO:0008150,GO:0008152,GO:0015672,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030001,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0051179,GO:0051234,GO:0055114,GO:0098796,GO:1902494 1.6.5.8 ko:K00346 - - - - ko00000,ko01000 - - - NQRA,NQRA_SLBB k59_1118487_1 436308.Nmar_1233 1.46e-49 162.0 COG1909@1|root,arCOG04076@2157|Archaea,41SNQ@651137|Thaumarchaeota 651137|Thaumarchaeota S Belongs to the UPF0218 family - - - ko:K09735 - - - - ko00000 - - - DUF359 k59_564662_1 717785.HYPMC_4421 2.29e-88 270.0 COG0825@1|root,COG0825@2|Bacteria,1MURN@1224|Proteobacteria,2TR6V@28211|Alphaproteobacteria,3N6KI@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA accA - 2.1.3.15,6.4.1.2 ko:K01962 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - ACCA k59_564662_2 991905.SL003B_0348 7.86e-26 102.0 COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,2TRAA@28211|Alphaproteobacteria,4BQ1V@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria L Phage integrase, N-terminal SAM-like domain xerD - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_523399_1 1429851.X548_15340 2.13e-83 280.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1X41A@135614|Xanthomonadales 135614|Xanthomonadales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K18303 - M00642 - - ko00000,ko00002,ko01504,ko02000 2.A.6.2.17 - - ACR_tran k59_523406_1 74547.PMT_1914 3.06e-06 50.1 COG1212@1|root,COG1212@2|Bacteria,1G067@1117|Cyanobacteria,1MNDE@1212|Prochloraceae 1117|Cyanobacteria M Cytidylyltransferase kdsB - 2.7.7.38 ko:K00979 ko00540,ko01100,map00540,map01100 M00063 R03351,R11396 RC00152,RC00910 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CTP_transf_3 k59_523406_2 312153.Pnuc_0281 1.21e-74 229.0 COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,2VH1C@28216|Betaproteobacteria,1K44B@119060|Burkholderiaceae 28216|Betaproteobacteria F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism adk GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ADK,ADK_lid k59_354948_1 1123393.KB891327_gene267 6.68e-74 238.0 COG1262@1|root,COG1262@2|Bacteria,1MUNC@1224|Proteobacteria,2VH4V@28216|Betaproteobacteria,1KS1R@119069|Hydrogenophilales 119069|Hydrogenophilales S DinB superfamily - - - - - - - - - - - - DinB_2,FGE-sulfatase k59_564699_1 314271.RB2654_12584 3e-76 246.0 COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2TRC5@28211|Alphaproteobacteria 28211|Alphaproteobacteria P (belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family) - - - ko:K03455,ko:K11745,ko:K11747 - - - - ko00000,ko02000 2.A.37,2.A.37.1.1,2.A.37.1.2 - - Na_H_Exchanger,TrkA_N k59_651007_1 580332.Slit_1184 1.37e-25 108.0 COG2200@1|root,COG3829@1|root,COG2200@2|Bacteria,COG3829@2|Bacteria,1NTHT@1224|Proteobacteria,2W1FA@28216|Betaproteobacteria,44WAB@713636|Nitrosomonadales 28216|Betaproteobacteria KT TIGRFAM PAS sensor protein - - - - - - - - - - - - EAL,PAS_4 k59_651007_2 522306.CAP2UW1_1956 4.59e-34 125.0 2CDFS@1|root,32RXQ@2|Bacteria,1N09V@1224|Proteobacteria,2VUR5@28216|Betaproteobacteria,1KR01@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria S Protein of unknown function (DUF2946) - - - - - - - - - - - - DUF2944 k59_438184_1 1211777.BN77_1030 1.06e-21 102.0 COG0583@1|root,COG0747@1|root,COG0583@2|Bacteria,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TU1J@28211|Alphaproteobacteria,4BBAS@82115|Rhizobiaceae 28211|Alphaproteobacteria E ABC transporter substrate-binding protein - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_1248136_1 479434.Sthe_1421 1.13e-19 88.6 COG0055@1|root,COG0055@2|Bacteria,2G5JI@200795|Chloroflexi,27XYE@189775|Thermomicrobia 189775|Thermomicrobia C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N k59_1248136_2 1382306.JNIM01000001_gene200 2.07e-27 107.0 COG0224@1|root,COG0224@2|Bacteria,2G69I@200795|Chloroflexi 200795|Chloroflexi C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex atpG - - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt k59_523445_1 159450.NH14_16320 8.47e-12 64.3 COG1804@1|root,COG1804@2|Bacteria,1MW1H@1224|Proteobacteria,2VJJQ@28216|Betaproteobacteria,1K237@119060|Burkholderiaceae 28216|Betaproteobacteria C PFAM L-carnitine dehydratase bile acid-inducible protein F - - 5.1.99.4 ko:K01796 ko00120,ko01100,ko04146,map00120,map01100,map04146 M00104 R08734,R08739 RC02345 ko00000,ko00001,ko00002,ko01000 - - - CoA_transf_3 k59_523445_2 1097668.BYI23_C004530 9.77e-61 197.0 COG1414@1|root,COG1414@2|Bacteria,1R4WS@1224|Proteobacteria,2VQMK@28216|Betaproteobacteria,1KHY6@119060|Burkholderiaceae 28216|Betaproteobacteria K helix_turn_helix isocitrate lyase regulation - - - - - - - - - - - - HTH_IclR,IclR k59_611527_1 987059.RBXJA2T_14411 2.33e-71 234.0 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,2VHBS@28216|Betaproteobacteria,1KIVP@119065|unclassified Burkholderiales 28216|Betaproteobacteria M peptidase - - - - - - - - - - - - Peptidase_M23 k59_438202_1 1192759.AKIB01000003_gene698 6.26e-51 171.0 COG2130@1|root,COG2130@2|Bacteria,1MUC2@1224|Proteobacteria,2TQYM@28211|Alphaproteobacteria,2K21X@204457|Sphingomonadales 204457|Sphingomonadales L alcohol dehydrogenase - - - ko:K07119 - - - - ko00000 - - - ADH_N_2,ADH_zinc_N k59_438202_2 536019.Mesop_3464 1.12e-17 82.4 COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,2TRGS@28211|Alphaproteobacteria,43NEJ@69277|Phyllobacteriaceae 28211|Alphaproteobacteria E Belongs to the GcvT family - - 1.5.8.4 ko:K00315 ko00260,ko01100,map00260,map01100 - R01565 RC00181 ko00000,ko00001,ko01000 - - - DAO,FAO_M,GCV_T,GCV_T_C k59_794223_2 479434.Sthe_2434 3.25e-30 121.0 COG0166@1|root,COG0176@1|root,COG0166@2|Bacteria,COG0176@2|Bacteria,2G67J@200795|Chloroflexi,27XXA@189775|Thermomicrobia 189775|Thermomicrobia G Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway tal - 2.2.1.2,5.3.1.9 ko:K13810 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00004,M00007,M00114 R01827,R02739,R02740,R03321 RC00376,RC00439,RC00563,RC00604 ko00000,ko00001,ko00002,ko01000 - - - PGI,TAL_FSA k59_534417_1 1100720.ALKN01000052_gene507 2.72e-93 288.0 COG2271@1|root,COG2271@2|Bacteria,1QTW2@1224|Proteobacteria 1224|Proteobacteria G Major facilitator Superfamily MA20_02120 - - - - - - - - - - - MFS_1 k59_829546_1 397945.Aave_2024 3.72e-92 289.0 COG0296@1|root,COG0296@2|Bacteria,1MVM7@1224|Proteobacteria,2W14D@28216|Betaproteobacteria,4AJPK@80864|Comamonadaceae 28216|Betaproteobacteria G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 k59_235675_1 1150469.RSPPHO_02501 2.65e-74 243.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TRKS@28211|Alphaproteobacteria,2JPS3@204441|Rhodospirillales 204441|Rhodospirillales I Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_704990_1 323848.Nmul_A2344 3.97e-128 382.0 COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,2VIW1@28216|Betaproteobacteria,372Q8@32003|Nitrosomonadales 28216|Betaproteobacteria O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL - - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_235729_1 1123367.C666_15030 3.86e-144 438.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2VI87@28216|Betaproteobacteria,2KVBJ@206389|Rhodocyclales 206389|Rhodocyclales L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate - - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_1173836_1 640081.Dsui_3135 1.4e-93 288.0 COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,2VIG2@28216|Betaproteobacteria,2KUKU@206389|Rhodocyclales 206389|Rhodocyclales O HflC and HflK could encode or regulate a protease - - - ko:K04088 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7,HflK_N k59_574669_1 864051.BurJ1DRAFT_3653 2.63e-97 305.0 COG4231@1|root,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2VK1K@28216|Betaproteobacteria 28216|Betaproteobacteria C indolepyruvate ferredoxin oxidoreductase - - 1.2.7.8 ko:K00179 - - - - br01601,ko00000,ko01000 - - - TPP_enzyme_C k59_276392_1 1056820.KB900631_gene2306 2.19e-55 184.0 COG4240@1|root,COG4240@2|Bacteria,1QUTA@1224|Proteobacteria,1T23W@1236|Gammaproteobacteria,2PNEU@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria S COG4240 Predicted kinase - - 2.7.1.31 ko:K15918 ko00260,ko00561,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00561,map00630,map01100,map01110,map01130,map01200 M00532 R01514 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - ArgK,PRK k59_276392_2 715226.ABI_14530 6.91e-27 103.0 COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,2TTVR@28211|Alphaproteobacteria,2KG9D@204458|Caulobacterales 204458|Caulobacterales O Glutathione S-transferase - - - ko:K11209 - - - - ko00000,ko01000 - - - GST_C,GST_C_2,GST_N,GST_N_3 k59_960618_1 686340.Metal_0101 2.69e-119 358.0 COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,1RMYE@1236|Gammaproteobacteria,1XDMC@135618|Methylococcales 1236|Gammaproteobacteria J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS - 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD k59_449236_1 640081.Dsui_2996 9.35e-151 441.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,2KV9Y@206389|Rhodocyclales 206389|Rhodocyclales NU Type II secretion system (T2SS), protein E, N-terminal domain - - - ko:K02454 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSE,T2SSE_N k59_491834_1 1031711.RSPO_c01200 7.86e-78 258.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,2VJ57@28216|Betaproteobacteria,1K0FY@119060|Burkholderiaceae 28216|Betaproteobacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_235775_1 104623.Ser39006_01225 6.92e-09 61.6 COG1566@1|root,COG1566@2|Bacteria,1MU7I@1224|Proteobacteria,1RNHA@1236|Gammaproteobacteria,4025P@613|Serratia 1236|Gammaproteobacteria V secretion protein HlyD family emrA - - ko:K03543 - M00701 - - ko00000,ko00002,ko02000 8.A.1.1 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_624730_1 1238182.C882_2906 8.2e-57 199.0 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,2TRY7@28211|Alphaproteobacteria,2JPFA@204441|Rhodospirillales 204441|Rhodospirillales H Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell glnE - 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_1348644_2 1408164.MOLA814_02449 1.49e-22 94.0 COG2068@1|root,COG2068@2|Bacteria,1MW0X@1224|Proteobacteria,2VT4G@28216|Betaproteobacteria 28216|Betaproteobacteria S 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase - - 1.1.1.328,2.7.7.76 ko:K07141,ko:K19190 ko00760,ko00790,ko01120,map00760,map00790,map01120 - R10131,R10132,R11582 RC03053 ko00000,ko00001,ko01000 - - - NTP_transf_3 k59_1051323_1 1131553.JIBI01000014_gene845 2.07e-81 269.0 COG0493@1|root,COG0543@1|root,COG0493@2|Bacteria,COG0543@2|Bacteria,1PV5D@1224|Proteobacteria,2WB3J@28216|Betaproteobacteria,37281@32003|Nitrosomonadales 28216|Betaproteobacteria CEH PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Pyr_redox_2 k59_491873_1 1282360.ABAC460_10305 1.89e-51 170.0 COG0346@1|root,COG0346@2|Bacteria,1RHRF@1224|Proteobacteria 1224|Proteobacteria E glyoxalase bleomycin resistance protein dioxygenase - - - - - - - - - - - - Glyoxalase k59_1301127_1 1123020.AUIE01000054_gene1796 5.99e-18 77.4 COG0824@1|root,COG0824@2|Bacteria,1N8J9@1224|Proteobacteria,1TC08@1236|Gammaproteobacteria,1YJJV@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S Thioesterase-like superfamily - - - ko:K07107 - - - - ko00000,ko01000 - - - 4HBT_2 k59_1301127_2 948106.AWZT01000039_gene1168 7.67e-67 211.0 COG0288@1|root,COG0288@2|Bacteria,1NGFN@1224|Proteobacteria,2VIBS@28216|Betaproteobacteria,1K3GU@119060|Burkholderiaceae 28216|Betaproteobacteria P Reversible hydration of carbon dioxide can - 4.2.1.1 ko:K01673 ko00910,map00910 - R00132,R10092 RC02807 ko00000,ko00001,ko01000 - - - Acetyltransf_1,Pro_CA k59_624764_1 443144.GM21_0061 7.46e-49 166.0 COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,42NJJ@68525|delta/epsilon subdivisions,2WJGI@28221|Deltaproteobacteria,43SZG@69541|Desulfuromonadales 28221|Deltaproteobacteria H Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) pdxA - 1.1.1.262,1.1.1.408,1.1.1.409 ko:K00097,ko:K22024 ko00750,ko01100,map00750,map01100 M00124 R05681,R05837,R07406 RC00089,RC00675,RC01475 ko00000,ko00001,ko00002,ko01000 - - - PdxA k59_624764_2 502025.Hoch_5049 3.31e-07 51.2 COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,42MET@68525|delta/epsilon subdivisions,2WITH@28221|Deltaproteobacteria,2YUC2@29|Myxococcales 28221|Deltaproteobacteria G Phosphoglucomutase/phosphomannomutase, C-terminal domain algC - 5.4.2.2,5.4.2.8 ko:K01840,ko:K15778 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_1173922_1 395493.BegalDRAFT_2688 1.41e-25 110.0 COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,1RNN3@1236|Gammaproteobacteria,462AI@72273|Thiotrichales 72273|Thiotrichales P PFAM von Willebrand factor type A domain - - - ko:K02448 - - R00294 RC02794 ko00000 3.D.4.10 - - - k59_1348690_1 367737.Abu_0994 3.64e-15 80.9 COG3437@1|root,COG5001@1|root,COG3437@2|Bacteria,COG5001@2|Bacteria,1MUB8@1224|Proteobacteria,42ZE8@68525|delta/epsilon subdivisions,2YRGW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T HD domain - - - - - - - - - - - - HD,PAS,PAS_3,dCache_3 k59_872671_1 1380394.JADL01000011_gene4022 4.21e-37 141.0 COG3214@1|root,COG3214@2|Bacteria,1N40B@1224|Proteobacteria,2TT7U@28211|Alphaproteobacteria,2JQ7G@204441|Rhodospirillales 204441|Rhodospirillales S Winged helix DNA-binding domain - - - ko:K09927 - - - - ko00000 - - - HTH_42 k59_491903_1 1552758.NC00_01825 7.2e-37 130.0 COG0605@1|root,COG0605@2|Bacteria,1MVW2@1224|Proteobacteria,1RP7X@1236|Gammaproteobacteria,1X3PD@135614|Xanthomonadales 135614|Xanthomonadales P Destroys radicals which are normally produced within the cells and which are toxic to biological systems sodB - 1.15.1.1 ko:K04564 ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016 - - - ko00000,ko00001,ko01000 - - - Sod_Fe_C,Sod_Fe_N k59_106036_1 1123073.KB899241_gene3006 2.83e-57 192.0 COG2816@1|root,COG2816@2|Bacteria,1QGCX@1224|Proteobacteria,1RP0Y@1236|Gammaproteobacteria,1X4JM@135614|Xanthomonadales 135614|Xanthomonadales L nadh pyrophosphatase nudC - 3.6.1.22 ko:K03426 ko00760,ko01100,ko04146,map00760,map01100,map04146 - R00103,R03004,R11104 RC00002 ko00000,ko00001,ko01000 - - - NUDIX,NUDIX-like,zf-NADH-PPase k59_148428_1 1122137.AQXF01000001_gene3113 1.84e-24 96.7 COG1051@1|root,COG1051@2|Bacteria,1REBW@1224|Proteobacteria,2U72I@28211|Alphaproteobacteria 28211|Alphaproteobacteria F COG1051 ADP-ribose pyrophosphatase - - - - - - - - - - - - NUDIX,Nudix_N_2 k59_148428_2 426117.M446_3411 5.78e-29 110.0 COG2917@1|root,COG2917@2|Bacteria,1NWIZ@1224|Proteobacteria,2U74X@28211|Alphaproteobacteria,1JSQ8@119045|Methylobacteriaceae 28211|Alphaproteobacteria D probably involved in intracellular septation ispZ - - ko:K06190 - - - - ko00000 - - - IspA k59_829710_2 1380391.JIAS01000012_gene4124 1.81e-31 121.0 COG2114@1|root,COG2114@2|Bacteria,1ND4Q@1224|Proteobacteria,2U51W@28211|Alphaproteobacteria,2JXWG@204441|Rhodospirillales 204441|Rhodospirillales T Protein of unknown function (DUF2652) - - - - - - - - - - - - DUF2652 k59_534618_1 864069.MicloDRAFT_00047500 1.1e-205 594.0 COG0654@1|root,COG1902@1|root,COG0654@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,2TQPY@28211|Alphaproteobacteria,1JU1B@119045|Methylobacteriaceae 28211|Alphaproteobacteria CH NADH:flavin oxidoreductase / NADH oxidase family - - 1.14.13.40 ko:K09461 ko00627,ko01120,map00627,map01120 - R03998,R03999 RC00244 ko00000,ko00001,ko01000 - - - FAD_binding_3,Oxidored_FMN k59_368207_1 1229909.NSED_06260 4.81e-40 144.0 COG0119@1|root,arCOG02092@2157|Archaea,41SBX@651137|Thaumarchaeota 651137|Thaumarchaeota E Belongs to the alpha-IPM synthase homocitrate synthase family - - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_368207_2 436308.Nmar_1071 7.13e-48 156.0 COG0440@1|root,arCOG04445@2157|Archaea,41SNS@651137|Thaumarchaeota 651137|Thaumarchaeota E acetolactate synthase, small - - 2.2.1.6 ko:K01653 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - ACT,ACT_5,ALS_ss_C k59_1216774_1 640081.Dsui_0888 8.39e-75 232.0 COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,2VIR9@28216|Betaproteobacteria,2KUHG@206389|Rhodocyclales 206389|Rhodocyclales D Rod shape-determining protein MreB mreB - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl k59_1216774_2 1123261.AXDW01000016_gene3109 5.18e-28 104.0 COG0721@1|root,COG0721@2|Bacteria,1MZQP@1224|Proteobacteria,1S8VY@1236|Gammaproteobacteria,1X7YB@135614|Xanthomonadales 135614|Xanthomonadales J Glu-tRNAGln amidotransferase C subunit - - - - - - - - - - - - Glu-tRNAGln k59_325193_1 1089552.KI911559_gene1682 4.76e-127 389.0 COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,2TVZI@28211|Alphaproteobacteria,2JQ15@204441|Rhodospirillales 204441|Rhodospirillales C Formate dehydrogenase subunit alpha - - - - - - - - - - - - Fer2_4,Fer4_7,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_406665_1 1121430.JMLG01000028_gene1457 5.38e-40 147.0 COG0403@1|root,COG0403@2|Bacteria,1TQGG@1239|Firmicutes,2492A@186801|Clostridia,2608E@186807|Peptococcaceae 186801|Clostridia E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvPA - 1.4.4.2 ko:K00282 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 - R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko01000 - - - GDC-P k59_534705_1 1380394.JADL01000003_gene4832 1.38e-103 317.0 COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,2TQK5@28211|Alphaproteobacteria,2JSIF@204441|Rhodospirillales 204441|Rhodospirillales C Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - - - - - - - - - - Fer4,Fer4_20,Fer4_7,Fer4_9,Pyr_redox_2,Pyr_redox_3 k59_747846_1 1198232.CYCME_1314 8.95e-50 172.0 COG2960@1|root,COG2960@2|Bacteria,1NJYD@1224|Proteobacteria,1RYI7@1236|Gammaproteobacteria 1236|Gammaproteobacteria M long-chain fatty acid transporting porin activity - - - - - - - - - - - - - k59_25270_2 292415.Tbd_2287 1e-12 67.0 COG3647@1|root,COG3647@2|Bacteria,1N7NB@1224|Proteobacteria,2VQQJ@28216|Betaproteobacteria 28216|Betaproteobacteria S Predicted membrane protein (DUF2238) - - - ko:K08984 - - - - ko00000 - - - DUF2238 k59_872822_1 448385.sce6319 6.31e-120 356.0 COG3344@1|root,COG3344@2|Bacteria,1REEG@1224|Proteobacteria,43BHY@68525|delta/epsilon subdivisions,2X6WC@28221|Deltaproteobacteria,2Z3DB@29|Myxococcales 1224|Proteobacteria L High confidence in function and specificity - - - - - - - - - - - - RVT_1 k59_662425_1 87626.PTD2_14822 3.94e-41 139.0 COG0509@1|root,COG0509@2|Bacteria,1RGV7@1224|Proteobacteria,1S656@1236|Gammaproteobacteria,2Q2GT@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria E The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein gcvH GO:0001505,GO:0003674,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008289,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0017144,GO:0019464,GO:0019752,GO:0031405,GO:0031406,GO:0033293,GO:0036094,GO:0042133,GO:0042135,GO:0042737,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0048037,GO:0050662,GO:0065007,GO:0065008,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1901681 - ko:K02437 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221 RC00022,RC02834 ko00000,ko00001,ko00002 - - iE2348C_1286.E2348C_3156,iPC815.YPO0906 GCV_H k59_662425_2 236097.ADG881_3280 9.24e-35 130.0 COG0403@1|root,COG0403@2|Bacteria,1MVC1@1224|Proteobacteria,1RPGZ@1236|Gammaproteobacteria,1XQZJ@135619|Oceanospirillales 135619|Oceanospirillales E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvPA - 1.4.4.2 ko:K00282 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 - R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko01000 - - - GDC-P k59_1216923_1 882378.RBRH_00185 1.59e-128 375.0 COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,2VHV3@28216|Betaproteobacteria,1JZSI@119060|Burkholderiaceae 28216|Betaproteobacteria E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine trpB GO:0000162,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0042802,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.20 ko:K01696 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_747913_1 504728.K649_09815 1.43e-150 434.0 COG0141@1|root,COG0141@2|Bacteria,1WKWX@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus E Histidinol dehydrogenase - - 1.1.1.308 ko:K15509 - - - - ko00000,ko01000 - - - Histidinol_dh k59_25327_1 469383.Cwoe_4214 7.05e-41 145.0 COG0045@1|root,COG0045@2|Bacteria,2GKSB@201174|Actinobacteria 201174|Actinobacteria C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit - - 6.2.1.18 ko:K15232 ko00720,ko01100,ko01120,ko01200,map00720,map01100,map01120,map01200 M00173 R01322 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2 k59_25327_2 469383.Cwoe_4215 1.74e-27 108.0 COG0074@1|root,COG0074@2|Bacteria,2GK00@201174|Actinobacteria 201174|Actinobacteria C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit sucD GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 6.2.1.5 ko:K01902 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - CoA_binding,Ligase_CoA k59_747918_1 1123257.AUFV01000012_gene2945 2.29e-46 159.0 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,1RPSE@1236|Gammaproteobacteria,1X9EU@135614|Xanthomonadales 135614|Xanthomonadales E Pyridoxal-phosphate dependent enzyme - - - - - - - - - - - - PALP k59_747918_2 159087.Daro_3366 4.48e-33 125.0 COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,2VI46@28216|Betaproteobacteria,2KVJW@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) - - 6.2.1.30 ko:K01912 ko00360,ko01120,ko05111,map00360,map01120,map05111 - R02539 RC00004,RC00014 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C_2 k59_1259603_1 671143.DAMO_1148 1.62e-82 256.0 COG0123@1|root,COG0123@2|Bacteria,2NP8V@2323|unclassified Bacteria 2|Bacteria BQ Histone deacetylase domain acuC - - ko:K04768 - - - - ko00000 - - - Hist_deacetyl k59_1093988_1 1517681.HW45_27030 3.3e-05 48.5 COG3266@1|root,COG3267@1|root,COG3266@2|Bacteria,COG3267@2|Bacteria,1Q1YI@1224|Proteobacteria,1S965@1236|Gammaproteobacteria,1XSV9@135623|Vibrionales 135623|Vibrionales U AAA domain VP2743 - - ko:K03112 - - - - ko00000 - - - AAA_22,SPOR k59_575019_1 404589.Anae109_2407 1.44e-105 311.0 COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,43AKQ@68525|delta/epsilon subdivisions,2X60P@28221|Deltaproteobacteria,2YWQF@29|Myxococcales 28221|Deltaproteobacteria C 4Fe-4S dicluster domain - - - ko:K00184 - - - - ko00000 5.A.3 - - Fer4_11,Fer4_4 k59_625077_1 296591.Bpro_1845 1.16e-21 91.7 COG5588@1|root,COG5588@2|Bacteria,1RGIE@1224|Proteobacteria,2VNWW@28216|Betaproteobacteria 28216|Betaproteobacteria S Protein of unknown function (DUF1326) - - - - - - - - - - - - DUF1326 k59_449588_1 1286093.C266_20614 2.57e-69 234.0 COG2199@1|root,COG2200@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,1RGCV@1224|Proteobacteria,2WGQE@28216|Betaproteobacteria,1KIJZ@119060|Burkholderiaceae 28216|Betaproteobacteria T diguanylate cyclase - - - - - - - - - - - - DUF2222,EAL,GGDEF,HAMP k59_662487_1 926569.ANT_19020 8.58e-102 305.0 COG0050@1|root,COG0050@2|Bacteria,2G5KI@200795|Chloroflexi 200795|Chloroflexi J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 k59_449606_1 757424.Hsero_2970 3.34e-52 176.0 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,2VIJF@28216|Betaproteobacteria,472V7@75682|Oxalobacteraceae 28216|Betaproteobacteria H Belongs to the citrate synthase family gltA - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_449606_2 296591.Bpro_2624 1.73e-18 86.3 COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,2VJ0G@28216|Betaproteobacteria,4AA22@80864|Comamonadaceae 28216|Betaproteobacteria C dehydrogenase, E1 component sucA - 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_1051713_1 234267.Acid_5012 1.5e-72 235.0 COG0008@1|root,COG0008@2|Bacteria,3Y7DS@57723|Acidobacteria 57723|Acidobacteria J tRNA synthetases class I (E and Q), anti-codon binding domain - - 6.1.1.18 ko:K01886 ko00970,ko01100,map00970,map01100 M00359,M00360 R03652 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1c,tRNA-synt_1c_C k59_534869_1 1100720.ALKN01000026_gene1697 1.04e-233 658.0 COG0318@1|root,COG0318@2|Bacteria,1MUMC@1224|Proteobacteria,2VGZE@28216|Betaproteobacteria,4AGKN@80864|Comamonadaceae 28216|Betaproteobacteria IQ AMP-binding enzyme C-terminal domain - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_276779_1 1380358.JADJ01000028_gene4071 9.49e-28 110.0 COG2908@1|root,COG2908@2|Bacteria,1N3U7@1224|Proteobacteria,1RP1X@1236|Gammaproteobacteria,1XJWG@135619|Oceanospirillales 135619|Oceanospirillales S Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxH - 3.6.1.54 ko:K03269 ko00540,ko01100,map00540,map01100 M00060 R04549 RC00002 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Metallophos,Metallophos_2 k59_276779_2 768066.HELO_2439 1.25e-33 123.0 COG4445@1|root,COG4445@2|Bacteria,1MVFE@1224|Proteobacteria,1RQ8Z@1236|Gammaproteobacteria,1XIJ2@135619|Oceanospirillales 135619|Oceanospirillales FJ Hydroxylase for synthesis of 2-methylthio-cis-ribozeatin in tRNA miaE - - ko:K06169 - - - - ko00000,ko01000,ko03016 - - - MiaE k59_193768_1 76114.ebA1185 1.09e-112 339.0 COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,2VIW1@28216|Betaproteobacteria,2KUH8@206389|Rhodocyclales 206389|Rhodocyclales O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groEL - - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_1349004_1 1219035.NT2_02_05640 6.56e-52 173.0 COG1028@1|root,COG1028@2|Bacteria,1MUFX@1224|Proteobacteria,2TRWN@28211|Alphaproteobacteria,2K5UJ@204457|Sphingomonadales 204457|Sphingomonadales IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short_C2 k59_794712_1 460265.Mnod_0373 1.33e-40 144.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TSGZ@28211|Alphaproteobacteria,1JUJU@119045|Methylobacteriaceae 28211|Alphaproteobacteria L PFAM transposase IS116 IS110 IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_70497_1 1354722.JQLS01000008_gene2349 6.97e-14 77.0 COG1275@1|root,COG1275@2|Bacteria,1MVPG@1224|Proteobacteria,2U072@28211|Alphaproteobacteria,46N99@74030|Roseovarius 28211|Alphaproteobacteria P COG1275 Tellurite resistance protein and related permeases tehA - - ko:K03304 - - - - ko00000,ko02000 2.A.16.1 - - SLAC1 k59_148771_1 269796.Rru_A1746 1.69e-94 285.0 COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,2TT0T@28211|Alphaproteobacteria,2JQNJ@204441|Rhodospirillales 204441|Rhodospirillales E COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_492250_1 765910.MARPU_05495 1.47e-06 48.1 COG0454@1|root,COG0456@2|Bacteria,1RIE6@1224|Proteobacteria,1S9G0@1236|Gammaproteobacteria,1WYDP@135613|Chromatiales 135613|Chromatiales K Ribosomal-protein-alanine acetyltransferase - - 2.3.1.128 ko:K03789 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_1 k59_492250_2 395019.Bmul_1234 1.73e-94 287.0 COG1573@1|root,COG1573@2|Bacteria,1MWX1@1224|Proteobacteria,2VPZQ@28216|Betaproteobacteria,1K1QM@119060|Burkholderiaceae 28216|Betaproteobacteria L TIGRFAM phage SPO1 DNA polymerase-related protein dpo - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_29518_1 404589.Anae109_3082 2.84e-28 113.0 COG0697@1|root,COG0697@2|Bacteria,1R46X@1224|Proteobacteria,42U0G@68525|delta/epsilon subdivisions,2WT9T@28221|Deltaproteobacteria 28221|Deltaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA k59_240617_1 1125863.JAFN01000001_gene3005 5.96e-54 180.0 COG5281@1|root,COG5281@2|Bacteria,1NZ1M@1224|Proteobacteria 1224|Proteobacteria D sister chromatid segregation - - - - - - - - - - - - - k59_453720_1 1203554.HMPREF1476_02117 1.76e-08 58.5 COG0589@1|root,COG0589@2|Bacteria,1N8EJ@1224|Proteobacteria,2VUAF@28216|Betaproteobacteria,4PQ9K@995019|Sutterellaceae 28216|Betaproteobacteria T Universal stress protein family - - - - - - - - - - - - Usp k59_453720_2 1122236.KB905146_gene1902 1.9e-24 103.0 COG3213@1|root,COG3213@2|Bacteria,1MUJK@1224|Proteobacteria,2VJ75@28216|Betaproteobacteria,2KNIV@206350|Nitrosomonadales 206350|Nitrosomonadales P NnrS protein - - - ko:K07234 - - - - ko00000 - - - NnrS k59_29545_1 1000565.METUNv1_01354 2.43e-93 298.0 COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,2VP2Q@28216|Betaproteobacteria,2KVNP@206389|Rhodocyclales 206389|Rhodocyclales C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Fer2_4,Fer4,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_453746_1 652103.Rpdx1_1872 5.28e-67 214.0 COG1638@1|root,COG1638@2|Bacteria,1R7GB@1224|Proteobacteria,2U0ZQ@28211|Alphaproteobacteria,3K3KS@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria G Bacterial extracellular solute-binding protein, family 7 - - - - - - - - - - - - DctP k59_709472_1 883126.HMPREF9710_01218 7.14e-38 139.0 COG1466@1|root,COG1466@2|Bacteria,1MWYT@1224|Proteobacteria,2VIKX@28216|Betaproteobacteria,472XE@75682|Oxalobacteraceae 28216|Betaproteobacteria L DNA polymerase III (Delta subunit) holA - 2.7.7.7 ko:K02340 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delt_C,DNA_pol3_delta k59_752071_1 331869.BAL199_29090 9.31e-32 117.0 COG3791@1|root,COG3791@2|Bacteria 2|Bacteria S Glutathione-dependent formaldehyde-activating - - - - - - - - - - - - GFA k59_752071_2 710696.Intca_0369 4.63e-14 71.6 COG0596@1|root,COG1506@1|root,COG3710@1|root,COG0596@2|Bacteria,COG1506@2|Bacteria,COG3710@2|Bacteria,2HASC@201174|Actinobacteria 201174|Actinobacteria K Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Trans_reg_C k59_922719_1 1385935.N836_03240 1.8e-05 47.8 2EM9G@1|root,33EYK@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_922719_2 1500897.JQNA01000002_gene4133 7.31e-34 119.0 COG1917@1|root,COG1917@2|Bacteria,1N7QJ@1224|Proteobacteria,2VVHY@28216|Betaproteobacteria,1KEKH@119060|Burkholderiaceae 28216|Betaproteobacteria S Cupin 2, conserved barrel - - - ko:K21700 - - - - ko00000 - - - Cupin_2 k59_759731_1 1265313.HRUBRA_01299 1.01e-63 210.0 COG2939@1|root,COG2939@2|Bacteria,1MW05@1224|Proteobacteria,1RQJY@1236|Gammaproteobacteria,1J58C@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E COG2939 Carboxypeptidase C (cathepsin A) - - - - - - - - - - - - Peptidase_S10 k59_1107918_1 318586.Pden_2196 7.96e-16 80.5 COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,2TSM8@28211|Alphaproteobacteria,2PUGF@265|Paracoccus 28211|Alphaproteobacteria CH D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain gyaR2 - 1.1.1.215,1.1.1.26,1.1.1.79,1.1.1.81 ko:K00015,ko:K00050,ko:K00090 ko00030,ko00260,ko00620,ko00630,ko01100,ko01110,ko01120,map00030,map00260,map00620,map00630,map01100,map01110,map01120 - R00465,R00717,R01388,R01392,R01739 RC00031,RC00042,RC00084 ko00000,ko00001,ko01000 - - - 2-Hacid_dh,2-Hacid_dh_C k59_587057_1 251229.Chro_4769 4.55e-11 62.8 COG0604@1|root,COG0604@2|Bacteria,1G0N4@1117|Cyanobacteria,3VJSQ@52604|Pleurocapsales 1117|Cyanobacteria C PFAM Alcohol dehydrogenase GroES-like domain - - - - - - - - - - - - ADH_N,ADH_zinc_N_2 k59_587057_2 1121403.AUCV01000088_gene2976 3.29e-38 132.0 COG0703@1|root,COG0703@2|Bacteria,1P4F5@1224|Proteobacteria,433KK@68525|delta/epsilon subdivisions,2WY9G@28221|Deltaproteobacteria,2MP7E@213118|Desulfobacterales 28221|Deltaproteobacteria E Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate - - - - - - - - - - - - - k59_118423_1 684719.HIMB114_00002650 5.67e-07 49.7 COG0139@1|root,COG0139@2|Bacteria,1MW67@1224|Proteobacteria,2UCKH@28211|Alphaproteobacteria,4BRY9@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP hisI - 3.5.4.19,3.6.1.31 ko:K01496,ko:K11755 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04035,R04037 RC00002,RC01055 ko00000,ko00001,ko00002,ko01000 - - - PRA-CH,PRA-PH k59_118423_2 999541.bgla_2g01580 2.62e-54 184.0 COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,2VMQA@28216|Betaproteobacteria,1KBMC@119060|Burkholderiaceae 28216|Betaproteobacteria J DALR_2 - - 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,tRNA-synt_1e k59_37568_1 261292.Nit79A3_2721 7.78e-38 131.0 COG0346@1|root,COG0346@2|Bacteria,1N7R0@1224|Proteobacteria,2WARN@28216|Betaproteobacteria,373B2@32003|Nitrosomonadales 28216|Betaproteobacteria C PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - - - - - - - - - - Glyoxalase k59_118431_1 1234595.C725_1619 4.36e-06 49.3 COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,2TTMV@28211|Alphaproteobacteria,4BQWG@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Zinc-binding dehydrogenase MA20_28180 - 1.1.1.1 ko:K00001,ko:K13953 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_118431_2 1380386.JIAW01000003_gene445 1.71e-163 473.0 COG0405@1|root,COG0405@2|Bacteria,2GJYW@201174|Actinobacteria,2354G@1762|Mycobacteriaceae 201174|Actinobacteria E gamma-glutamyltransferase ggtA - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_972921_1 1408164.MOLA814_00217 3.03e-100 314.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,2VHQ3@28216|Betaproteobacteria,1KQD3@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria G Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate ppsA - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_1360941_2 1231185.BAMP01000060_gene133 3.89e-59 184.0 2CXUS@1|root,32T2P@2|Bacteria,1MZIZ@1224|Proteobacteria,2UBZF@28211|Alphaproteobacteria,43PP0@69277|Phyllobacteriaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - YGGT k59_1108007_1 331869.BAL199_01614 4.62e-56 184.0 COG1878@1|root,COG1878@2|Bacteria,1MVWU@1224|Proteobacteria,2TUQ1@28211|Alphaproteobacteria,4BSYN@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Putative cyclase - - - - - - - - - - - - Cyclase k59_840287_1 570952.ATVH01000011_gene541 7.13e-37 142.0 COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,2TR1W@28211|Alphaproteobacteria,2JQ21@204441|Rhodospirillales 204441|Rhodospirillales FP Ppx/GppA phosphatase family - - 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000 - - - Ppx-GppA k59_118464_1 1408254.T458_25445 8.58e-45 156.0 COG0157@1|root,COG0157@2|Bacteria,1TPQC@1239|Firmicutes,4HB46@91061|Bacilli,26QFZ@186822|Paenibacillaceae 91061|Bacilli H Belongs to the NadC ModD family nadC GO:0003674,GO:0003824,GO:0004514,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016054,GO:0016740,GO:0016757,GO:0016763,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034213,GO:0034641,GO:0034654,GO:0042737,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046395,GO:0046483,GO:0046496,GO:0046700,GO:0046874,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0072526,GO:0090407,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 2.4.2.19 ko:K00767 ko00760,ko01100,map00760,map01100 M00115 R03348 RC02877 ko00000,ko00001,ko00002,ko01000 - - - QRPTase_C,QRPTase_N k59_82428_1 1207063.P24_14804 2.1e-84 263.0 COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,2TT03@28211|Alphaproteobacteria,2JPHV@204441|Rhodospirillales 204441|Rhodospirillales L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA - - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k59_972956_2 391615.ABSJ01000052_gene1272 4.18e-24 97.1 COG1188@1|root,COG1188@2|Bacteria,1MZR6@1224|Proteobacteria,1S8VU@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the HSP15 family hslR GO:0003674,GO:0003676,GO:0003677,GO:0003723,GO:0003727,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009451,GO:0009628,GO:0009987,GO:0016070,GO:0033554,GO:0034605,GO:0034641,GO:0043021,GO:0043023,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 - ko:K04762 - - - - ko00000,ko03110 - - - S4 k59_546821_1 1121106.JQKB01000003_gene2482 5.56e-26 101.0 COG4297@1|root,COG4297@2|Bacteria,1RB1W@1224|Proteobacteria,2U14J@28211|Alphaproteobacteria,2JTMM@204441|Rhodospirillales 204441|Rhodospirillales S protein containing double-stranded beta helix domain - - - - - - - - - - - - Cupin_1,Cupin_2 k59_546821_2 85643.Tmz1t_0478 1.8e-38 132.0 COG1633@1|root,COG1633@2|Bacteria,1RJFW@1224|Proteobacteria,2VT5X@28216|Betaproteobacteria,2KWJT@206389|Rhodocyclales 206389|Rhodocyclales S Rubrerythrin - - - - - - - - - - - - Rubrerythrin k59_248954_1 296591.Bpro_2564 4.5e-50 176.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2VHMA@28216|Betaproteobacteria,4A9UE@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM acyl-CoA dehydrogenase domain protein aidB - - ko:K09456 - - - - ko00000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M k59_461731_1 398527.Bphyt_4717 1.28e-27 113.0 COG0223@1|root,COG0223@2|Bacteria,1NN5V@1224|Proteobacteria,2VWHM@28216|Betaproteobacteria,1K8SD@119060|Burkholderiaceae 28216|Betaproteobacteria J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus - - - - - - - - - - - - - k59_1015357_1 497964.CfE428DRAFT_3655 2.22e-51 174.0 COG0484@1|root,COG0484@2|Bacteria,46TKC@74201|Verrucomicrobia 74201|Verrucomicrobia O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_1015357_2 228410.NE0779 2.75e-05 46.2 COG1385@1|root,COG1385@2|Bacteria,1MXCU@1224|Proteobacteria,2VJS2@28216|Betaproteobacteria,372EJ@32003|Nitrosomonadales 28216|Betaproteobacteria J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit rsmE - 2.1.1.193 ko:K09761 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_RNA k59_639175_2 1454004.AW11_02853 4.72e-49 159.0 COG1006@1|root,COG1006@2|Bacteria,1RGU1@1224|Proteobacteria 1224|Proteobacteria P COG1006 Multisubunit Na H antiporter, MnhC subunit mnhC - - ko:K05567 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - Oxidored_q2 k59_639175_3 398579.Spea_3282 6.3e-46 159.0 COG2111@1|root,COG2111@2|Bacteria,1N1CK@1224|Proteobacteria,1RR3K@1236|Gammaproteobacteria,2Q9B0@267890|Shewanellaceae 1236|Gammaproteobacteria P PFAM Na H antiporter MnhB subunit-related protein - - - ko:K05566 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - DUF4040,MnhB k59_639175_4 1469245.JFBG01000065_gene119 0.000488 42.0 COG2111@1|root,COG2111@2|Bacteria,1N1CK@1224|Proteobacteria,1RR3K@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Na H antiporter, MnhB - - - ko:K05566 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - DUF4040,MnhB k59_37703_1 640081.Dsui_3260 4.99e-79 255.0 COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,2VI3K@28216|Betaproteobacteria,2KV9E@206389|Rhodocyclales 206389|Rhodocyclales C Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_419792_1 768671.ThimaDRAFT_0203 1.2e-66 223.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,1WXWN@135613|Chromatiales 135613|Chromatiales I PFAM 3-hydroxyacyl-CoA dehydrogenase - - 1.1.1.35,4.2.1.17,5.1.2.3 ko:K01782 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_1186451_1 296591.Bpro_2800 3.14e-206 584.0 COG0028@1|root,COG0028@2|Bacteria,1MXDW@1224|Proteobacteria,2VHRD@28216|Betaproteobacteria,4ABWV@80864|Comamonadaceae 28216|Betaproteobacteria EH Belongs to the TPP enzyme family oxc - 4.1.1.8 ko:K01577 ko00630,ko01100,map00630,map01100 - R01908 RC00620 ko00000,ko00001,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1361088_1 1336233.JAEH01000018_gene3067 5.73e-24 108.0 COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,1RQEX@1236|Gammaproteobacteria,2Q8WX@267890|Shewanellaceae 1236|Gammaproteobacteria M Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane lptD GO:0005575,GO:0005623,GO:0006810,GO:0006869,GO:0008150,GO:0009279,GO:0009636,GO:0009987,GO:0010876,GO:0015920,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0042221,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044462,GO:0044464,GO:0045229,GO:0050896,GO:0051179,GO:0051234,GO:0061024,GO:0071702,GO:0071709,GO:0071840,GO:0071944,GO:1901264 - ko:K04744 - - - - ko00000,ko02000 1.B.42.1 - iG2583_1286.G2583_0058 OstA,OstA_C k59_1229290_1 1205680.CAKO01000037_gene1300 6.5e-10 58.9 COG1028@1|root,COG1028@2|Bacteria,1MUPX@1224|Proteobacteria,2TT6C@28211|Alphaproteobacteria,2JS3E@204441|Rhodospirillales 204441|Rhodospirillales IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short_C2 k59_1229290_2 883078.HMPREF9695_03089 2.18e-63 210.0 COG2114@1|root,COG2267@1|root,COG2114@2|Bacteria,COG2267@2|Bacteria,1QXEH@1224|Proteobacteria,2TX96@28211|Alphaproteobacteria,3K6W1@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria IT Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - Abhydrolase_1,FHA,Guanylate_cyc k59_717509_1 159087.Daro_3260 1.84e-49 171.0 COG2010@1|root,COG3391@1|root,COG2010@2|Bacteria,COG3391@2|Bacteria,1PYK3@1224|Proteobacteria,2VIU7@28216|Betaproteobacteria,2KU6N@206389|Rhodocyclales 206389|Rhodocyclales C cytochrome nirN - - - - - - - - - - - Cytochrom_D1,Cytochrome_CBB3 k59_717509_2 1304883.KI912532_gene3180 1.23e-58 190.0 COG0664@1|root,COG0664@2|Bacteria,1R5P7@1224|Proteobacteria,2VIQI@28216|Betaproteobacteria,2KVHP@206389|Rhodocyclales 206389|Rhodocyclales K COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases - - - ko:K21563 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding k59_1138935_1 555778.Hneap_2113 2.94e-07 55.5 COG3087@1|root,COG3087@2|Bacteria,1RCC0@1224|Proteobacteria,1SWTF@1236|Gammaproteobacteria,1WZTX@135613|Chromatiales 135613|Chromatiales D Sporulation related domain - - - - - - - - - - - - SPOR k59_205852_1 1502851.FG93_05626 6.54e-44 157.0 COG3845@1|root,COG3845@2|Bacteria,1NT0H@1224|Proteobacteria,2UPJ8@28211|Alphaproteobacteria,3JTM8@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MA20_34815 - 3.6.3.17 ko:K02056 - M00221 - - ko00000,ko00002,ko01000,ko02000 3.A.1.2 - - ABC_tran k59_205852_2 604331.AUHY01000003_gene1096 1.78e-15 76.3 COG1975@1|root,COG1975@2|Bacteria,1WJVB@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus O XdhC and CoxI family - - - ko:K07402 - - - - ko00000 - - - XdhC_C,XdhC_CoxI k59_1361149_1 1095769.CAHF01000001_gene3488 1.54e-23 97.8 COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,2VIWS@28216|Betaproteobacteria,472DJ@75682|Oxalobacteraceae 28216|Betaproteobacteria NU Type II/IV secretion system protein pilU - - ko:K02670 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_1361149_4 1123393.KB891333_gene2532 8.12e-20 81.3 2DNSI@1|root,32YXC@2|Bacteria,1N7K2@1224|Proteobacteria,2VVXF@28216|Betaproteobacteria,1KTHS@119069|Hydrogenophilales 119069|Hydrogenophilales - - - - - - - - - - - - - - - k59_806743_1 266809.PM03_04590 1.48e-44 152.0 COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,2TSGS@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q ABC-type transport system involved in resistance to organic solvents permease component mlaE - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE k59_806743_2 1150626.PHAMO_20032 1.34e-56 183.0 COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,2TR2I@28211|Alphaproteobacteria,2JQ66@204441|Rhodospirillales 204441|Rhodospirillales Q COG1127 ABC-type transport system involved in resistance to organic solvents, ATPase component mkl - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran k59_160920_2 1502770.JQMG01000001_gene1102 1.54e-28 112.0 COG1565@1|root,COG1565@2|Bacteria,1N3CJ@1224|Proteobacteria,2VHBE@28216|Betaproteobacteria,2KKBV@206350|Nitrosomonadales 206350|Nitrosomonadales S Putative S-adenosyl-L-methionine-dependent methyltransferase - - - - - - - - - - - - Methyltransf_28 k59_806763_1 247634.GPB2148_112 4.67e-42 147.0 COG3185@1|root,COG3185@2|Bacteria,1MUVZ@1224|Proteobacteria,1RN2Z@1236|Gammaproteobacteria,1J5BP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG3185 4-hydroxyphenylpyruvate dioxygenase and related hemolysins hppD - 1.13.11.27 ko:K00457 ko00130,ko00350,ko00360,ko01100,map00130,map00350,map00360,map01100 M00044 R01372,R02521 RC00505,RC00738 ko00000,ko00001,ko00002,ko01000,ko04147 - - iJN746.PP_3433 Glyoxalase,Glyoxalase_5 k59_806763_2 314265.R2601_06288 1.53e-49 161.0 COG0346@1|root,COG0346@2|Bacteria,1MWCV@1224|Proteobacteria,2TTXE@28211|Alphaproteobacteria 28211|Alphaproteobacteria E glyoxalase - - - ko:K08234 - - - - ko00000 - - - Glyoxalase k59_249166_1 1121352.JHZP01000001_gene654 2.99e-54 176.0 COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,2VIKC@28216|Betaproteobacteria,2KQ3X@206351|Neisseriales 206351|Neisseriales C Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family sdhB - 1.3.5.1,1.3.5.4 ko:K00240 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - Fer2_3,Fer4_17 k59_249166_2 1158292.JPOE01000005_gene346 1.69e-34 130.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2VHM6@28216|Betaproteobacteria,1KJ0V@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily sdhA GO:0000104,GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016627,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045273,GO:0045274,GO:0045281,GO:0045282,GO:0045333,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363,GO:1902494,GO:1990204 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_118721_1 1049564.TevJSym_ac00650 3.68e-83 264.0 COG0589@1|root,COG0589@2|Bacteria 2|Bacteria T AMP binding - - - - - - - - - - - - Usp k59_1235819_2 522306.CAP2UW1_2814 1.12e-18 86.7 COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,2VH78@28216|Betaproteobacteria,1KQH6@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria H MoeA N-terminal region (domain I and II) moeA2 - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N k59_125144_1 641524.ADICYQ_5472 5.06e-69 223.0 COG3119@1|root,COG3119@2|Bacteria,4NHH7@976|Bacteroidetes,47JYR@768503|Cytophagia 976|Bacteroidetes P PFAM sulfatase mdsA - - - - - - - - - - - DUF4976,Sulfatase k59_979567_1 1123392.AQWL01000005_gene2967 5.56e-62 194.0 COG2967@1|root,COG2967@2|Bacteria,1MZ2Z@1224|Proteobacteria,2VSPE@28216|Betaproteobacteria,1KT3H@119069|Hydrogenophilales 119069|Hydrogenophilales P ApaG domain - - - - - - - - - - - - DUF525 k59_125146_1 62928.azo3068 3.21e-31 126.0 COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2VH59@28216|Betaproteobacteria,2KV56@206389|Rhodocyclales 206389|Rhodocyclales I Acetyl propionyl-CoA carboxylase, alpha subunit - - 6.4.1.4 ko:K01968 ko00280,ko01100,map00280,map01100 M00036 R04138 RC00367,RC00942 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_979569_1 225937.HP15_3954 9.96e-27 109.0 COG0614@1|root,COG0614@2|Bacteria,1MWVF@1224|Proteobacteria,1RMV8@1236|Gammaproteobacteria,466A4@72275|Alteromonadaceae 1236|Gammaproteobacteria P COG0614 ABC-type Fe3 -hydroxamate transport system, periplasmic component btuF GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0008144,GO:0008150,GO:0015889,GO:0015893,GO:0019842,GO:0030288,GO:0030313,GO:0031419,GO:0031975,GO:0036094,GO:0042221,GO:0042493,GO:0042597,GO:0044464,GO:0046906,GO:0048037,GO:0050896,GO:0051179,GO:0051180,GO:0051181,GO:0051234,GO:0071702,GO:0071705,GO:0097159,GO:1901363 - ko:K02016,ko:K06858 ko02010,map02010 M00240,M00241 - - ko00000,ko00001,ko00002,ko02000 3.A.1.13,3.A.1.14 - iECH74115_1262.ECH74115_0168,iECSP_1301.ECSP_0159,iECs_1301.ECs0162,iZ_1308.Z0169 Peripla_BP_2 k59_295502_2 472759.Nhal_1528 2.16e-09 58.5 2EBH3@1|root,335HM@2|Bacteria,1NDXE@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_1193030_1 240015.ACP_2205 2.84e-67 215.0 COG0010@1|root,COG0010@2|Bacteria,3Y46E@57723|Acidobacteria,2JIPY@204432|Acidobacteriia 204432|Acidobacteriia E Arginase family - - 3.5.3.1 ko:K01476 ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146 M00029,M00134 R00551 RC00024,RC00329 ko00000,ko00001,ko00002,ko01000 - - - Arginase k59_212355_1 640081.Dsui_3052 3.47e-68 214.0 COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,2VIRP@28216|Betaproteobacteria,2KW1X@206389|Rhodocyclales 206389|Rhodocyclales G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) tpiA - 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - TIM k59_766442_1 1123229.AUBC01000005_gene630 1.32e-110 333.0 COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,3JVY3@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Tripartite tricarboxylate transporter TctA family - - - ko:K07793 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.80.1 - - TctA k59_125208_1 936455.KI421499_gene3981 5.66e-18 79.0 COG2080@1|root,COG2080@2|Bacteria,1RE5X@1224|Proteobacteria,2U87N@28211|Alphaproteobacteria,3JXQQ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C [2Fe-2S] binding domain - - 1.3.99.8 ko:K16879 ko00365,ko01120,map00365,map01120 - R02987 RC01856 ko00000,ko00001,ko01000 - - - Fer2,Fer2_2 k59_125208_2 666509.RCA23_c12070 4.67e-40 142.0 COG1319@1|root,COG1319@2|Bacteria,1MUDB@1224|Proteobacteria,2TRA8@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM - - 1.2.5.3,1.3.99.8 ko:K03519,ko:K16878 ko00365,ko01120,map00365,map01120 - R02987,R11168 RC01856,RC02800 ko00000,ko00001,ko01000 - - - CO_deh_flav_C,FAD_binding_5 k59_1278350_1 713587.THITH_01715 2.51e-56 197.0 COG1067@1|root,COG1638@1|root,COG1067@2|Bacteria,COG1638@2|Bacteria,1MWGB@1224|Proteobacteria,1RMPC@1236|Gammaproteobacteria,1WXPW@135613|Chromatiales 135613|Chromatiales O Belongs to the peptidase S16 family - - - - - - - - - - - - AAA_32,Lon_C k59_295584_1 1207063.P24_03830 1.29e-58 203.0 COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TSN5@28211|Alphaproteobacteria,2JP8A@204441|Rhodospirillales 204441|Rhodospirillales C FAD linked oxidases, C-terminal domain - - - ko:K18930 - - - - ko00000 - - - CCG,FAD-oxidase_C,FAD_binding_4,Fer4_8 k59_766501_1 76114.ebA1268 5.73e-50 170.0 COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,2VIBN@28216|Betaproteobacteria,2KVXU@206389|Rhodocyclales 206389|Rhodocyclales J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs rlmN - 2.1.1.192 ko:K06941 - - - - ko00000,ko01000,ko03009 - - - Radical_SAM k59_766501_2 1265502.KB905935_gene3068 1.26e-48 157.0 COG0105@1|root,COG0105@2|Bacteria,1R9ZA@1224|Proteobacteria,2VQ2J@28216|Betaproteobacteria,4ADHY@80864|Comamonadaceae 28216|Betaproteobacteria F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate ndk - 2.7.4.6 ko:K00940 ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016 M00049,M00050,M00052,M00053 R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895 RC00002 ko00000,ko00001,ko00002,ko01000,ko04131 - - - NDK k59_255609_1 349124.Hhal_0659 1.13e-90 294.0 COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,1RMQE@1236|Gammaproteobacteria,1WXF0@135613|Chromatiales 135613|Chromatiales K 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs rnr - - ko:K12573 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03016,ko03019 - - - HTH_12,OB_RNB,RNB,S1 k59_724129_1 1121035.AUCH01000017_gene2298 5.72e-74 246.0 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,2VI2G@28216|Betaproteobacteria,2KV4M@206389|Rhodocyclales 206389|Rhodocyclales O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD - 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,GlnD_UR_UTase,HD,NTP_transf_2 k59_979727_1 1123257.AUFV01000021_gene2018 6.09e-52 176.0 COG3239@1|root,COG3239@2|Bacteria,1MY4I@1224|Proteobacteria,1S0IS@1236|Gammaproteobacteria,1X4IQ@135614|Xanthomonadales 135614|Xanthomonadales I Fatty acid desaturase - - 1.14.19.23,1.14.19.45 ko:K10255 ko02020,map02020 - - - ko00000,ko00001,ko01000,ko01004 - - - FA_desaturase k59_1320887_1 1286093.C266_15819 1.46e-61 195.0 COG0461@1|root,COG0461@2|Bacteria,1MVP7@1224|Proteobacteria,2VSR8@28216|Betaproteobacteria,1K1C7@119060|Burkholderiaceae 28216|Betaproteobacteria F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) pyrE - 2.4.2.10 ko:K00762 ko00240,ko01100,map00240,map01100 M00051 R01870 RC00611 ko00000,ko00001,ko00002,ko01000 - - - Pribosyltran k59_1320887_2 857087.Metme_0981 2.65e-28 109.0 COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,1RN4H@1236|Gammaproteobacteria,1XEVR@135618|Methylococcales 135618|Methylococcales L Endonuclease/Exonuclease/phosphatase family - - 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos k59_1236035_1 305700.B447_19454 1.05e-80 247.0 COG0568@1|root,COG0568@2|Bacteria,1MVWR@1224|Proteobacteria,2VI91@28216|Betaproteobacteria,2KUT2@206389|Rhodocyclales 206389|Rhodocyclales K RNA polymerase sigma rpoH - - ko:K03089 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r4 k59_1022167_1 1038867.AXAY01000051_gene766 3.42e-43 154.0 COG2114@1|root,COG2267@1|root,COG2114@2|Bacteria,COG2267@2|Bacteria,1QXEH@1224|Proteobacteria,2TX96@28211|Alphaproteobacteria,3K6W1@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria IT Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - Abhydrolase_1,FHA,Guanylate_cyc k59_1144655_1 1089546.AQUI01000002_gene3607 2.63e-61 201.0 COG1052@1|root,COG1052@2|Bacteria,2I2IC@201174|Actinobacteria,408AW@622450|Actinopolysporales 201174|Actinobacteria CH D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain - - 1.1.1.29 ko:K00018 ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200 M00346 R00717,R01388 RC00031,RC00042 ko00000,ko00001,ko00002,ko01000 - - - 2-Hacid_dh,2-Hacid_dh_C k59_937572_2 472759.Nhal_0245 2.7e-12 67.8 COG4977@1|root,COG4977@2|Bacteria,1MUDK@1224|Proteobacteria,1RP9W@1236|Gammaproteobacteria,1X2E9@135613|Chromatiales 135613|Chromatiales K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - DJ-1_PfpI,HTH_18 k59_208660_1 1205680.CAKO01000002_gene2985 8.6e-86 260.0 COG0411@1|root,COG0411@2|Bacteria,1MXHT@1224|Proteobacteria,2TSWS@28211|Alphaproteobacteria,2JQJ2@204441|Rhodospirillales 204441|Rhodospirillales E COG0411 ABC-type branched-chain amino acid transport systems, ATPase component - - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_1189346_1 109760.SPPG_08087T1 1.46e-09 65.5 COG0553@1|root,KOG1000@2759|Eukaryota,38C05@33154|Opisthokonta,3PBVX@4751|Fungi 4751|Fungi A SNF2 family N-terminal domain - - - - - - - - - - - - Helicase_C,SNF2_N k59_340140_1 42565.FP66_09800 9.02e-60 201.0 COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,1RPZC@1236|Gammaproteobacteria,1XHAE@135619|Oceanospirillales 135619|Oceanospirillales J beta-lactamase - - - ko:K07576 - - - - ko00000 - - - Beta-Casp,Lactamase_B,Lactamase_B_2,RMMBL k59_1018323_1 511.JT27_13095 2.41e-40 139.0 2EJU9@1|root,33DIX@2|Bacteria,1NPED@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_507279_1 1173028.ANKO01000041_gene3232 9.83e-25 105.0 COG1566@1|root,COG1566@2|Bacteria,1G0GH@1117|Cyanobacteria,1H83H@1150|Oscillatoriales 1117|Cyanobacteria V Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - ko:K01993 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_507279_2 1380355.JNIJ01000019_gene4662 3.93e-53 180.0 COG4948@1|root,COG4948@2|Bacteria,1MW5B@1224|Proteobacteria,2UNXP@28211|Alphaproteobacteria,3JSCB@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M Mandelate racemase / muconate lactonizing enzyme, C-terminal domain MA20_01265 - 4.2.1.6 ko:K01684 ko00052,ko01100,ko01120,map00052,map01100,map01120 M00552 R03033 RC00543 ko00000,ko00001,ko00002,ko01000 - - - MR_MLE_C,MR_MLE_N k59_886095_1 1122135.KB893170_gene2791 2.08e-106 325.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TQJR@28211|Alphaproteobacteria 28211|Alphaproteobacteria I COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases prpE GO:0003674,GO:0003824,GO:0003987,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006091,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0017144,GO:0031974,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046950,GO:0046951,GO:0070013,GO:0071704,GO:1901568,GO:1901570,GO:1901576,GO:1902224 6.2.1.1,6.2.1.17 ko:K01895,ko:K01908 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_1189376_1 292415.Tbd_2028 1.91e-110 342.0 COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,2VHKJ@28216|Betaproteobacteria,1KSX1@119069|Hydrogenophilales 119069|Hydrogenophilales P Sulfate permease family - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_976012_1 1205680.CAKO01000008_gene4108 7.84e-84 260.0 COG0683@1|root,COG0683@2|Bacteria,1MV5T@1224|Proteobacteria,2TQZC@28211|Alphaproteobacteria,2JQDS@204441|Rhodospirillales 204441|Rhodospirillales E Periplasmic binding protein - - - - - - - - - - - - Peripla_BP_6 k59_40800_1 1484157.PSNIH2_19900 2.9e-40 148.0 COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,1RQTW@1236|Gammaproteobacteria,3W1FZ@53335|Pantoea 1236|Gammaproteobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_720446_1 1238450.VIBNISOn1_200034 2.85e-14 75.9 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,1RQ86@1236|Gammaproteobacteria,1XTCY@135623|Vibrionales 135623|Vibrionales U general secretion pathway protein epsF GO:0002790,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0016020,GO:0032940,GO:0033036,GO:0042886,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098776 - ko:K02455 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSF k59_720446_2 319795.Dgeo_0263 0.000124 44.3 COG2804@1|root,COG2804@2|Bacteria,1WIW9@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB pilF - - ko:K02652 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE,T2SSE_N k59_933785_1 485913.Krac_0573 1.9e-53 184.0 COG0607@1|root,COG2059@1|root,COG0607@2|Bacteria,COG2059@2|Bacteria,2G6NB@200795|Chloroflexi 200795|Chloroflexi P TIGRFAM chromate transporter, chromate ion transporter (CHR) family - - - ko:K07240 - - - - ko00000,ko02000 2.A.51.1 - - Chromate_transp k59_383448_1 266834.SMc04250 1.11e-44 159.0 COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,1N207@1224|Proteobacteria,2UEQQ@28211|Alphaproteobacteria,4BC7V@82115|Rhizobiaceae 28211|Alphaproteobacteria L Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - ko:K07497 - - - - ko00000 - - - HTH_28,HTH_32,LZ_Tnp_IS481,rve,rve_3 k59_291912_1 1238182.C882_0004 5.12e-80 249.0 COG2170@1|root,COG2170@2|Bacteria,1MX4N@1224|Proteobacteria,2TR20@28211|Alphaproteobacteria,2JPF7@204441|Rhodospirillales 204441|Rhodospirillales H ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity - - - ko:K06048 - - - - ko00000,ko01000 - - - GCS2 k59_252076_1 396588.Tgr7_0544 3.01e-08 54.7 2B4XH@1|root,31XQC@2|Bacteria,1RHJF@1224|Proteobacteria,1S3S1@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_252076_2 396588.Tgr7_0547 6.33e-31 114.0 COG0526@1|root,COG0526@2|Bacteria,1MZ36@1224|Proteobacteria,1S8UU@1236|Gammaproteobacteria,1WZ4W@135613|Chromatiales 135613|Chromatiales CO Thioredoxin-like - - - - - - - - - - - - AhpC-TSA,Redoxin k59_678484_1 378806.STAUR_1298 1.01e-69 226.0 COG2234@1|root,COG2234@2|Bacteria,1R77P@1224|Proteobacteria,438J4@68525|delta/epsilon subdivisions,2X8TJ@28221|Deltaproteobacteria,2YX3Q@29|Myxococcales 28221|Deltaproteobacteria S Peptidase family M28 - - - - - - - - - - - - Peptidase_M28 k59_464890_1 1469245.JFBG01000040_gene1743 4.79e-34 130.0 COG1566@1|root,COG1566@2|Bacteria,1MU7I@1224|Proteobacteria,1RMAD@1236|Gammaproteobacteria,1WYSU@135613|Chromatiales 135613|Chromatiales V PFAM secretion protein HlyD - - - ko:K03543 - M00701 - - ko00000,ko00002,ko02000 8.A.1.1 - - Biotin_lipoyl_2,HlyD_D23 k59_590348_1 977880.RALTA_A1350 2.09e-19 90.9 COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2VH50@28216|Betaproteobacteria,1K2H0@119060|Burkholderiaceae 28216|Betaproteobacteria I Poly(R)-hydroxyalkanoic acid synthase, class I phbC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K03821 ko00650,map00650 - R04254 RC00004 ko00000,ko00001,ko01000 - - - PhaC_N k59_507444_1 396588.Tgr7_0458 2.19e-30 123.0 COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,1RR36@1236|Gammaproteobacteria,1WYS8@135613|Chromatiales 135613|Chromatiales KLT serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - HAMP,HEAT_2,Pkinase,sCache_3_2 k59_464912_1 1123393.KB891316_gene1689 9.99e-99 302.0 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2VI5U@28216|Betaproteobacteria,1KRC2@119069|Hydrogenophilales 119069|Hydrogenophilales E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA ilvA - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP,Thr_dehydrat_C k59_886263_1 1000565.METUNv1_02088 5.55e-116 342.0 COG1622@1|root,COG1622@2|Bacteria,1MWHZ@1224|Proteobacteria,2VH9M@28216|Betaproteobacteria,2KV6W@206389|Rhodocyclales 206389|Rhodocyclales C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) - - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2,COX2_TM,Cytochrome_CBB3 k59_886263_2 550540.Fbal_0186 1.8e-33 127.0 COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,1RPC3@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B ctaD - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - iJN746.PP_0104 COX1 k59_1141570_1 1449044.JMLE01000013_gene2716 7.07e-44 155.0 COG2159@1|root,COG2159@2|Bacteria,2HEB4@201174|Actinobacteria 201174|Actinobacteria CH amidohydrolase - - 4.1.1.45 ko:K03392 ko00380,ko01100,map00380,map01100 M00038 R04323 RC00779 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_2 k59_252232_1 479435.Kfla_2127 2.6e-14 74.3 COG1893@1|root,COG1893@2|Bacteria,2GP6K@201174|Actinobacteria 201174|Actinobacteria H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid apbA - 1.1.1.169 ko:K00077 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R02472 RC00726 ko00000,ko00001,ko00002,ko01000 - - - ApbA,ApbA_C k59_252232_2 991.IW20_15510 2.44e-54 186.0 COG0129@1|root,COG0129@2|Bacteria,4NFHP@976|Bacteroidetes,1HX1X@117743|Flavobacteriia,2NU1S@237|Flavobacterium 976|Bacteroidetes E Belongs to the IlvD Edd family ilvD - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_465047_1 1123355.JHYO01000012_gene725 8.98e-62 199.0 COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,2TSDS@28211|Alphaproteobacteria,370AV@31993|Methylocystaceae 28211|Alphaproteobacteria E Branched-chain amino acid transport system / permease component natD - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_465047_2 991905.SL003B_2156 8.05e-16 76.3 COG0683@1|root,COG0683@2|Bacteria,1MWYP@1224|Proteobacteria,2TTAM@28211|Alphaproteobacteria 28211|Alphaproteobacteria E COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_41133_1 1380391.JIAS01000011_gene4717 1.69e-70 226.0 COG1252@1|root,COG1252@2|Bacteria,1MX96@1224|Proteobacteria,2TQT2@28211|Alphaproteobacteria,2JQWK@204441|Rhodospirillales 204441|Rhodospirillales C Pyridine nucleotide-disulphide oxidoreductase - - 1.6.99.3 ko:K03885 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_252305_1 1288494.EBAPG3_15740 6.88e-99 305.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2VHM6@28216|Betaproteobacteria,371TZ@32003|Nitrosomonadales 28216|Betaproteobacteria C Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily sdhA GO:0000104,GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016627,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045273,GO:0045274,GO:0045281,GO:0045282,GO:0045333,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363,GO:1902494,GO:1990204 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_292193_1 1144342.PMI40_02017 1.23e-108 326.0 COG1448@1|root,COG1448@2|Bacteria,1MUT0@1224|Proteobacteria,2VHNH@28216|Betaproteobacteria,472KW@75682|Oxalobacteraceae 28216|Betaproteobacteria E Aminotransferase class I and II tyrB - 2.6.1.57 ko:K00832 ko00270,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01230,map00270,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01230 M00024,M00025,M00034,M00040 R00694,R00734,R01731,R07396,R10845 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_1141757_1 123899.JPQP01000001_gene1675 6.8e-31 117.0 COG1787@1|root,COG1787@2|Bacteria,1RGGQ@1224|Proteobacteria,2VTJ4@28216|Betaproteobacteria,3T67P@506|Alcaligenaceae 28216|Betaproteobacteria V Restriction endonuclease - - - ko:K07448 - - - - ko00000,ko02048 - - - Mrr_cat k59_1232619_1 1235802.C823_00748 1.96e-10 66.6 COG0771@1|root,COG0771@2|Bacteria,1TQ3P@1239|Firmicutes,248GS@186801|Clostridia,25V78@186806|Eubacteriaceae 186801|Clostridia M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) murD - 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase_C,Mur_ligase_M k59_1232621_1 421052.F945_03067 1.04e-29 122.0 COG0642@1|root,COG2198@1|root,COG2199@1|root,COG2198@2|Bacteria,COG2205@2|Bacteria,COG3706@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,3NJVK@468|Moraxellaceae 1236|Gammaproteobacteria T Histidine kinase barA GO:0000155,GO:0000160,GO:0000302,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009636,GO:0009927,GO:0009987,GO:0010033,GO:0010035,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0035556,GO:0036211,GO:0042221,GO:0042493,GO:0042542,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046677,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007,GO:0070887,GO:0071310,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901700 2.7.13.3 ko:K07678 ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111 M00475 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - DUF2222,HAMP,HATPase_c,HisKA,Hpt,Response_reg k59_209122_1 666681.M301_0482 9.35e-46 155.0 COG0741@1|root,COG0741@2|Bacteria,1MZ4X@1224|Proteobacteria,2VKFN@28216|Betaproteobacteria,2KMXE@206350|Nitrosomonadales 206350|Nitrosomonadales M PFAM Lytic transglycosylase catalytic - - - - - - - - - - - - SLT k59_720836_1 1385935.N836_00115 5.91e-64 214.0 COG3039@1|root,COG3039@2|Bacteria,1G3IA@1117|Cyanobacteria,1HEFE@1150|Oscillatoriales 1117|Cyanobacteria L Transposase domain (DUF772) - - - - - - - - - - - - DDE_Tnp_1_6,DUF772 k59_423197_1 1207063.P24_11140 1.16e-59 207.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,2JQTV@204441|Rhodospirillales 204441|Rhodospirillales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family vexF - - ko:K18989 - M00720 - - ko00000,ko00002,ko02000 2.A.6.2.30 - - ACR_tran k59_252427_1 1049564.TevJSym_ac00580 6.53e-56 195.0 COG2010@1|root,COG2010@2|Bacteria,1R28S@1224|Proteobacteria,1T5JD@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Cytochrome c - - - - - - - - - - - - Cytochrome_CBB3 k59_164201_1 1040989.AWZU01000057_gene5081 5.07e-38 141.0 COG0725@1|root,COG0725@2|Bacteria,1PA2T@1224|Proteobacteria,2U1JI@28211|Alphaproteobacteria,3JUZJ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P Bacterial extracellular solute-binding protein - - 5.3.3.7 ko:K02020,ko:K22003 ko00660,ko02010,map00660,map02010 M00189 R02244 RC00668 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.8 - - SBP_bac_11 k59_1306625_1 414996.IL38_15235 8.97e-54 189.0 COG0068@1|root,COG0068@2|Bacteria,2GJYF@201174|Actinobacteria 201174|Actinobacteria O Belongs to the carbamoyltransferase HypF family hypF - - ko:K04656 - - - - ko00000 - - - Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF k59_198435_1 1165096.ARWF01000001_gene48 4.18e-34 120.0 COG0745@1|root,COG0745@2|Bacteria,1RDYB@1224|Proteobacteria,2VR2Q@28216|Betaproteobacteria,2KMW5@206350|Nitrosomonadales 206350|Nitrosomonadales T PFAM response regulator receiver - - - ko:K02657 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko02022,ko02035,ko02044 - - - Response_reg k59_198435_2 1349767.GJA_769 2.49e-54 172.0 COG0745@1|root,COG0745@2|Bacteria,1RI9T@1224|Proteobacteria,2VSSD@28216|Betaproteobacteria,474F2@75682|Oxalobacteraceae 28216|Betaproteobacteria KT cheY-homologous receiver domain pilH - - ko:K02658 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko02022,ko02035,ko02044 - - - Response_reg k59_198435_3 1454004.AW11_00426 2.77e-27 105.0 COG0835@1|root,COG0835@2|Bacteria,1N07Q@1224|Proteobacteria,2VU6N@28216|Betaproteobacteria 28216|Betaproteobacteria NT PFAM CheW domain protein pilI - - ko:K02659 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001,ko02035,ko02044 - - - CheW k59_1099532_1 1246995.AFR_04800 9.56e-43 153.0 COG0436@1|root,COG0436@2|Bacteria,2GJ7R@201174|Actinobacteria,4D8CW@85008|Micromonosporales 201174|Actinobacteria E Aminotransferase dapC - 2.6.1.1,2.6.1.17,2.6.1.2,2.6.1.66 ko:K00812,ko:K14260,ko:K14267 ko00220,ko00250,ko00270,ko00290,ko00300,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00290,map00300,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01120,map01130,map01210,map01230 M00016 R00258,R00355,R00694,R00734,R00896,R01215,R02433,R02619,R04475,R05052 RC00006,RC00008,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_281496_1 1177154.Y5S_00577 3.1e-19 81.6 2CCNX@1|root,32RW4@2|Bacteria,1N3P1@1224|Proteobacteria,1SAFG@1236|Gammaproteobacteria,1XMIS@135619|Oceanospirillales 135619|Oceanospirillales - - - - - - - - - - - - - - - k59_1306711_1 1121033.AUCF01000017_gene3754 4.6e-65 221.0 COG0004@1|root,COG0840@1|root,COG0004@2|Bacteria,COG0840@2|Bacteria,1NR9F@1224|Proteobacteria,2TT2J@28211|Alphaproteobacteria,2JPYA@204441|Rhodospirillales 204441|Rhodospirillales P COG0004 Ammonia permease - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp,MCPsignal k59_373221_1 1469607.KK073768_gene3005 8.36e-12 66.2 COG2242@1|root,COG2242@2|Bacteria,1GA4I@1117|Cyanobacteria 1117|Cyanobacteria HO Methyltransferase FkbM domain - - - - - - - - - - - - Methyltransf_21 k59_1008188_1 797210.Halxa_3333 1.67e-67 217.0 COG3839@1|root,arCOG00177@2157|Archaea,2XSVD@28890|Euryarchaeota,23SSF@183963|Halobacteria 183963|Halobacteria E COG3839 ABC-type sugar transport systems, ATPase components - - - ko:K10112 ko02010,map02010 M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1 - - ABC_tran,TOBE_2 k59_1008188_2 296591.Bpro_3817 1.37e-40 142.0 COG0395@1|root,COG0395@2|Bacteria,1QHIK@1224|Proteobacteria,2WEFG@28216|Betaproteobacteria,4AF3T@80864|Comamonadaceae 28216|Betaproteobacteria P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02026,ko:K10119 ko02010,map02010 M00196,M00207 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.28 - - BPD_transp_1 k59_667875_1 977880.RALTA_B2051 3.14e-120 354.0 COG3391@1|root,COG3391@2|Bacteria,1QD5Q@1224|Proteobacteria,2VH1W@28216|Betaproteobacteria 28216|Betaproteobacteria S cytochrome d1, heme region nirF - - ko:K19345 - - - - ko00000 - - - Cytochrom_D1 k59_1306759_1 1122135.KB893169_gene2561 3.92e-47 172.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria 28211|Alphaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family ttgE - - ko:K18989 - M00720 - - ko00000,ko00002,ko02000 2.A.6.2.30 - - ACR_tran k59_1221838_1 305700.B447_07232 1.74e-197 568.0 COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,2VH1K@28216|Betaproteobacteria,2KUE7@206389|Rhodocyclales 206389|Rhodocyclales O Belongs to the ClpA ClpB family clpA - - ko:K03694 - - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_281584_1 1126627.BAWE01000004_gene4069 3.69e-46 160.0 COG4663@1|root,COG4663@2|Bacteria,1MUXI@1224|Proteobacteria,2TQVW@28211|Alphaproteobacteria,3JWB9@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria Q Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - - - - - - - - - - DctP,TAT_signal k59_198556_1 85643.Tmz1t_2310 4.43e-14 72.0 COG1381@1|root,COG1381@2|Bacteria,1RHIC@1224|Proteobacteria,2VJUC@28216|Betaproteobacteria,2KW9J@206389|Rhodocyclales 206389|Rhodocyclales L Involved in DNA repair and RecF pathway recombination recO - - ko:K03584 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecO_C,RecO_N k59_198556_2 1123487.KB892841_gene4325 3.48e-67 210.0 COG0854@1|root,COG0854@2|Bacteria,1MU9W@1224|Proteobacteria,2VHY7@28216|Betaproteobacteria,2KV09@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate pdxJ - 2.6.99.2 ko:K03474 ko00750,ko01100,map00750,map01100 M00124 R05838 RC01476 ko00000,ko00001,ko00002,ko01000 - - - PdxJ k59_834217_1 76114.ebA3603 1.86e-34 136.0 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2VIR8@28216|Betaproteobacteria,2KVZ2@206389|Rhodocyclales 206389|Rhodocyclales C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain hcrA - 1.3.7.9 ko:K04108 ko00362,ko00627,ko01100,ko01120,ko01220,map00362,map00627,map01100,map01120,map01220 - R05316 RC00490 ko00000,ko00001,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_281603_1 1123504.JQKD01000005_gene4749 7.15e-15 73.9 COG4948@1|root,COG4948@2|Bacteria,1MV2S@1224|Proteobacteria,2VPM7@28216|Betaproteobacteria,4AGFV@80864|Comamonadaceae 28216|Betaproteobacteria M Enolase C-terminal domain-like - - - - - - - - - - - - MR_MLE_C k59_281603_2 698761.RTCIAT899_CH13555 6.05e-74 227.0 COG1670@1|root,COG1670@2|Bacteria,1MXEE@1224|Proteobacteria,2U62V@28211|Alphaproteobacteria,4B9QF@82115|Rhizobiaceae 28211|Alphaproteobacteria J Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_3 k59_1008260_1 395495.Lcho_2937 7.85e-15 73.2 COG0781@1|root,COG0781@2|Bacteria,1RHFZ@1224|Proteobacteria,2VSI6@28216|Betaproteobacteria,1KKV8@119065|unclassified Burkholderiales 28216|Betaproteobacteria K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons nusB - - ko:K03625 - - - - ko00000,ko03009,ko03021 - - - NusB k59_1008260_2 1121352.JHZP01000001_gene1012 5.09e-24 95.9 COG0054@1|root,COG0054@2|Bacteria,1RD9J@1224|Proteobacteria,2VQGE@28216|Betaproteobacteria,2KR6G@206351|Neisseriales 206351|Neisseriales H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin ribH - 2.5.1.78 ko:K00794 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R04457 RC00960 ko00000,ko00001,ko00002,ko01000 - - - DMRL_synthase k59_1132717_2 1366050.N234_28315 4.94e-63 198.0 COG0036@1|root,COG0036@2|Bacteria,1MUZM@1224|Proteobacteria,2VIGU@28216|Betaproteobacteria,1K6PJ@119060|Burkholderiaceae 28216|Betaproteobacteria F Belongs to the ribulose-phosphate 3-epimerase family rpe - 5.1.3.1 ko:K01783 ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01529 RC00540 ko00000,ko00001,ko00002,ko01000 - - - Ribul_P_3_epim k59_1221891_1 497321.C664_08878 3.65e-07 52.4 COG2823@1|root,COG2823@2|Bacteria,1N0SU@1224|Proteobacteria,2VUHT@28216|Betaproteobacteria,2KX6G@206389|Rhodocyclales 206389|Rhodocyclales S bacterial OsmY and nodulation domain - - - ko:K04065 - - - - ko00000 - - - BON k59_281644_1 887898.HMPREF0551_1003 5.19e-06 54.3 COG0664@1|root,COG0664@2|Bacteria,1RE4X@1224|Proteobacteria,2VRYB@28216|Betaproteobacteria,1K34H@119060|Burkholderiaceae 28216|Betaproteobacteria K Transcriptional regulator - - - ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - HTH_Crp_2,cNMP_binding k59_834261_1 891968.Anamo_1687 8.31e-48 171.0 COG0058@1|root,COG0058@2|Bacteria,3T9UV@508458|Synergistetes 508458|Synergistetes G alpha-glucan phosphorylase glgP - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - Phosphorylase k59_668014_1 76114.ebA2912 6.31e-75 231.0 COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,2VHNK@28216|Betaproteobacteria,2KV5R@206389|Rhodocyclales 206389|Rhodocyclales D involved in chromosome partitioning - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_877351_1 1517681.HW45_20445 2.07e-43 155.0 COG2358@1|root,COG2358@2|Bacteria,1MXW1@1224|Proteobacteria,1RQN1@1236|Gammaproteobacteria,1XU72@135623|Vibrionales 135623|Vibrionales S transport system periplasmic component - - - ko:K07080 - - - - ko00000 - - - NMT1_3 k59_198653_1 1122179.KB890436_gene1443 1.71e-39 144.0 COG3483@1|root,COG3483@2|Bacteria,4NFG4@976|Bacteroidetes,1IPQV@117747|Sphingobacteriia 976|Bacteroidetes E Tryptophan 2,3-dioxygenase kynA - 1.13.11.11 ko:K00453 ko00380,ko01100,map00380,map01100 M00038 R00678 RC00356 ko00000,ko00001,ko00002,ko01000 - - - Trp_dioxygenase k59_965941_1 1123393.KB891328_gene581 3.32e-93 283.0 COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,2VI24@28216|Betaproteobacteria,1KSCX@119069|Hydrogenophilales 119069|Hydrogenophilales M SIS domain - - 5.3.1.13 ko:K06041 ko00540,ko01100,map00540,map01100 M00063 R01530 RC00541 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CBS,SIS k59_111310_1 1218074.BAXZ01000017_gene3553 7.04e-15 72.8 COG1722@1|root,COG1722@2|Bacteria,1PTYP@1224|Proteobacteria,2VVQV@28216|Betaproteobacteria,1K9WF@119060|Burkholderiaceae 28216|Betaproteobacteria L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseB - 3.1.11.6 ko:K03602 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_S k59_111310_2 1485544.JQKP01000003_gene231 1.12e-102 306.0 COG0142@1|root,COG0142@2|Bacteria,1MWNG@1224|Proteobacteria,2VHQV@28216|Betaproteobacteria,44V0J@713636|Nitrosomonadales 28216|Betaproteobacteria H Polyprenyl synthetase ispA - 2.5.1.1,2.5.1.10 ko:K00795 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00364 R01658,R02003 RC00279 ko00000,ko00001,ko00002,ko01000,ko01006 - - - polyprenyl_synt k59_281736_1 1415779.JOMH01000001_gene898 2.41e-07 58.2 28H5T@1|root,2Z7IB@2|Bacteria,1N7V9@1224|Proteobacteria,1S23F@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1008387_1 439235.Dalk_3373 3.38e-65 217.0 COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,42N1H@68525|delta/epsilon subdivisions,2WJ0R@28221|Deltaproteobacteria,2MHVX@213118|Desulfobacterales 28221|Deltaproteobacteria C Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_965999_1 640081.Dsui_0224 8.54e-48 164.0 COG0583@1|root,COG0583@2|Bacteria,1MVA1@1224|Proteobacteria,2VIBJ@28216|Betaproteobacteria,2KVQD@206389|Rhodocyclales 206389|Rhodocyclales K LysR substrate binding domain - - - ko:K04761 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - HTH_1,LysR_substrate k59_281780_1 1236959.BAMT01000012_gene3039 6.19e-38 143.0 COG3164@1|root,COG3164@2|Bacteria,1MXWF@1224|Proteobacteria,2VH52@28216|Betaproteobacteria,2KKF5@206350|Nitrosomonadales 206350|Nitrosomonadales S Protein of unknown function - - - - - - - - - - - - AsmA_2,DUF3971 k59_580138_1 1304878.AUGD01000001_gene195 4.84e-74 232.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,3K066@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - DEDD_Tnp_IS110 k59_631071_2 1333998.M2A_1404 2.63e-36 132.0 COG0421@1|root,COG0421@2|Bacteria,1MVV5@1224|Proteobacteria,2TQZ3@28211|Alphaproteobacteria,4BTCE@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria H Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine speE - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synt_N,Spermine_synth k59_1132881_1 1380394.JADL01000014_gene182 2.14e-13 69.7 COG0412@1|root,COG0412@2|Bacteria,1MW88@1224|Proteobacteria,2U1D8@28211|Alphaproteobacteria,2JR1X@204441|Rhodospirillales 204441|Rhodospirillales Q Dienelactone hydrolase family - - 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 - R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 - - - DLH k59_1132881_2 264198.Reut_B5282 7.98e-09 58.5 COG0183@1|root,COG0183@2|Bacteria,1MUZV@1224|Proteobacteria,2VM79@28216|Betaproteobacteria,1K5PU@119060|Burkholderiaceae 28216|Betaproteobacteria I acetyl-coa acetyltransferase - - - - - - - - - - - - - k59_1057683_1 1235457.C404_09515 2.92e-33 122.0 COG1573@1|root,COG1573@2|Bacteria,1MWX1@1224|Proteobacteria,2VPZQ@28216|Betaproteobacteria,1K1QM@119060|Burkholderiaceae 28216|Betaproteobacteria L TIGRFAM phage SPO1 DNA polymerase-related protein dpo - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_1057683_2 1123073.KB899241_gene3140 1.78e-35 125.0 COG0454@1|root,COG0456@2|Bacteria,1RIE6@1224|Proteobacteria,1S9G0@1236|Gammaproteobacteria,1X6EJ@135614|Xanthomonadales 135614|Xanthomonadales K Ribosomal-protein-alanine acetyltransferase rimI - 2.3.1.128 ko:K03789 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_1 k59_1179340_1 231434.JQJH01000001_gene1729 2.75e-61 211.0 COG0457@1|root,COG2227@1|root,COG3914@1|root,COG0457@2|Bacteria,COG2227@2|Bacteria,COG3914@2|Bacteria,1MVMG@1224|Proteobacteria,2TRVB@28211|Alphaproteobacteria,3NAKJ@45404|Beijerinckiaceae 28211|Alphaproteobacteria HO Glycosyl transferase family 41 - - - - - - - - - - - - Glyco_transf_41,Methyltransf_23,TPR_1,TPR_11,TPR_16,TPR_2,TPR_8 k59_497278_1 391615.ABSJ01000055_gene1349 3.08e-89 276.0 COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,1RN7V@1236|Gammaproteobacteria,1J4RK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis hflX GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003924,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006417,GO:0006464,GO:0006468,GO:0006518,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006996,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018105,GO:0018193,GO:0018209,GO:0019001,GO:0019222,GO:0019538,GO:0019843,GO:0022411,GO:0030554,GO:0031323,GO:0031326,GO:0032268,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0032790,GO:0032984,GO:0032988,GO:0034248,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0036211,GO:0036289,GO:0043021,GO:0043022,GO:0043023,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0071826,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:2000112 - ko:K03665 - - - - ko00000,ko03009 - - - GTP-bdg_M,GTP-bdg_N,MMR_HSR1 k59_497302_1 713587.THITH_01405 5.79e-49 165.0 2BX2I@1|root,2Z9KR@2|Bacteria,1MXKC@1224|Proteobacteria,1RRV2@1236|Gammaproteobacteria,1WXVA@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_1307115_1 1470591.BW41_02249 1.16e-08 58.9 COG1213@1|root,COG1213@2|Bacteria,1RB54@1224|Proteobacteria,2U5XC@28211|Alphaproteobacteria,2K2S2@204457|Sphingomonadales 204457|Sphingomonadales M Nucleotidyltransferase - - - - - - - - - - - - NTP_transf_3,NTP_transferase k59_1307143_1 1048834.TC41_1964 1.33e-35 136.0 COG0008@1|root,COG0008@2|Bacteria,1TPJC@1239|Firmicutes,4HBS0@91061|Bacilli,279F0@186823|Alicyclobacillaceae 91061|Bacilli J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) - - 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - - tRNA-synt_1c k59_668300_1 580332.Slit_0060 1.82e-91 298.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,2VHYQ@28216|Betaproteobacteria,44V3A@713636|Nitrosomonadales 28216|Betaproteobacteria H Vitamin B12 dependent methionine synthase activation region metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_668301_1 98439.AJLL01000038_gene1799 3.39e-28 115.0 COG0477@1|root,COG2814@2|Bacteria,1G2N2@1117|Cyanobacteria,1JIC0@1189|Stigonemataceae 1117|Cyanobacteria EGP Transmembrane secretion effector - - - - - - - - - - - - MFS_3 k59_923776_1 1128912.GMES_3818 5.01e-36 142.0 COG2199@1|root,COG3292@1|root,COG3292@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,1RQCR@1236|Gammaproteobacteria,46686@72275|Alteromonadaceae 1236|Gammaproteobacteria T periplasmic ligand-binding sensor domain - - - - - - - - - - - - GGDEF,Reg_prop,Y_Y_Y k59_198870_1 331869.BAL199_25779 1.2e-55 194.0 COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,2TQTB@28211|Alphaproteobacteria,4BPAV@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase ntrY GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.13.3 ko:K13598 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS,PAS_4 k59_1307188_1 1120792.JAFV01000001_gene2618 2.6e-21 93.6 COG0697@1|root,COG0697@2|Bacteria,1RCED@1224|Proteobacteria,2U66Q@28211|Alphaproteobacteria,36ZMK@31993|Methylocystaceae 28211|Alphaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA k59_1307188_2 1266925.JHVX01000011_gene1510 2.71e-81 271.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,2VH3F@28216|Betaproteobacteria,3727S@32003|Nitrosomonadales 28216|Betaproteobacteria L TIGRFAM DNA polymerase III, alpha subunit dnaE - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_753138_1 595537.Varpa_1066 8.36e-76 244.0 COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,2VH54@28216|Betaproteobacteria,4AAIK@80864|Comamonadaceae 28216|Betaproteobacteria M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain glmU - 2.3.1.157,2.7.7.23 ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,Hexapep_2,NTP_transf_3 k59_198898_1 1249627.D779_0573 4.93e-55 182.0 COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,1RMEX@1236|Gammaproteobacteria,1WWPK@135613|Chromatiales 135613|Chromatiales C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family - - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_834511_1 1121405.dsmv_0691 2.89e-115 349.0 COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,42QDV@68525|delta/epsilon subdivisions,2WIRQ@28221|Deltaproteobacteria,2MN1S@213118|Desulfobacterales 68525|delta/epsilon subdivisions L PFAM transposase IS4 family protein - - - - - - - - - - - - DDE_Tnp_1 k59_1307236_1 1380391.JIAS01000018_gene825 2.21e-83 266.0 COG0747@1|root,COG0747@2|Bacteria,1MU3P@1224|Proteobacteria,2TT4M@28211|Alphaproteobacteria,2JQ75@204441|Rhodospirillales 204441|Rhodospirillales E Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_753167_1 1502851.FG93_03134 2.22e-47 168.0 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TQK7@28211|Alphaproteobacteria,3JSF3@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Bacterial extracellular solute-binding proteins, family 5 Middle MA20_19390 - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_241993_1 305900.GV64_07600 8.43e-40 140.0 COG2078@1|root,COG2078@2|Bacteria,1RJP4@1224|Proteobacteria,1S6FG@1236|Gammaproteobacteria,1XKXC@135619|Oceanospirillales 135619|Oceanospirillales S AMMECR1 - - - - - - - - - - - - AMMECR1 k59_153911_1 47716.JOFH01000010_gene4462 9.87e-37 134.0 COG2099@1|root,COG2099@2|Bacteria,2GMYZ@201174|Actinobacteria 201174|Actinobacteria H reductase cobK - 1.3.1.106,1.3.1.54 ko:K05895 ko00860,ko01100,map00860,map01100 - R05150,R05812 RC01280 ko00000,ko00001,ko01000 - - - CbiJ k59_710587_1 94624.Bpet4743 1.61e-202 579.0 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2VI0U@28216|Betaproteobacteria,3T1XK@506|Alcaligenaceae 28216|Betaproteobacteria I Long-chain acyl-CoA synthetases (AMP-forming) - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding k59_75737_1 1101192.KB910516_gene1219 1.44e-43 152.0 COG0656@1|root,COG0656@2|Bacteria,1MX6S@1224|Proteobacteria,2U0AU@28211|Alphaproteobacteria,1JS2Q@119045|Methylobacteriaceae 28211|Alphaproteobacteria S PFAM aldo keto reductase - - - - - - - - - - - - Aldo_ket_red k59_75737_2 1131814.JAFO01000001_gene509 5.18e-21 87.0 COG0221@1|root,COG0221@2|Bacteria,1RA2F@1224|Proteobacteria,2TQZM@28211|Alphaproteobacteria,3EZIE@335928|Xanthobacteraceae 28211|Alphaproteobacteria C Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions ppa - 3.6.1.1 ko:K01507 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyrophosphatase k59_373725_1 1000565.METUNv1_01948 7.42e-125 370.0 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,2VIHR@28216|Betaproteobacteria,2KUS9@206389|Rhodocyclales 206389|Rhodocyclales C glutamate synthase gltD - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - Fer4_20,Pyr_redox_2 k59_1057933_1 323848.Nmul_A2373 2.47e-46 162.0 COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,2VI8D@28216|Betaproteobacteria,372FK@32003|Nitrosomonadales 28216|Betaproteobacteria S GTPase that plays an essential role in the late steps of ribosome biogenesis der - - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 k59_1057933_2 1123367.C666_02890 5.38e-12 66.2 COG0477@1|root,COG2814@2|Bacteria,1MVZI@1224|Proteobacteria,2VHWT@28216|Betaproteobacteria,2KV5D@206389|Rhodocyclales 206389|Rhodocyclales EGP COG0477 Permeases of the major facilitator superfamily - - - ko:K05820 - - - - ko00000,ko02000 2.A.1.27 - - MFS_1_like k59_1008696_2 1188256.BASI01000009_gene118 4e-06 47.0 COG3791@1|root,COG3791@2|Bacteria,1N031@1224|Proteobacteria,2U9GY@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Glutathione-dependent formaldehyde-activating enzyme - - - - - - - - - - - - GFA k59_586002_2 1454004.AW11_00724 4.21e-79 247.0 COG2801@1|root,COG2801@2|Bacteria,1PBHA@1224|Proteobacteria,2VKPT@28216|Betaproteobacteria 28216|Betaproteobacteria L PFAM Integrase catalytic region - - - - - - - - - - - - rve k59_545696_1 1089544.KB912942_gene7097 0.000938 44.7 COG1752@1|root,COG1752@2|Bacteria,2IB41@201174|Actinobacteria,4DZ9K@85010|Pseudonocardiales 201174|Actinobacteria S Protein of unknown function (DUF3376) - GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - - - - - - - - - - DUF3376,Patatin k59_545696_2 670487.Ocepr_2109 5.07e-12 66.2 COG0739@1|root,COG1388@1|root,COG0739@2|Bacteria,COG1388@2|Bacteria,1WJ1A@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus M PFAM Peptidase family M23 - - - - - - - - - - - - LysM,Peptidase_M23 k59_379315_1 228410.NE0865 2.15e-14 76.6 COG2200@1|root,COG2200@2|Bacteria,1NTHT@1224|Proteobacteria,2W1FA@28216|Betaproteobacteria,372SS@32003|Nitrosomonadales 28216|Betaproteobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,PAS_4 k59_379315_2 1157708.KB907450_gene5811 2.51e-24 99.8 COG0824@1|root,COG2153@1|root,COG0824@2|Bacteria,COG2153@2|Bacteria,1MZ86@1224|Proteobacteria,2VMR6@28216|Betaproteobacteria,4A9NN@80864|Comamonadaceae 28216|Betaproteobacteria S Thioesterase superfamily protein yjcF - - - - - - - - - - - 4HBT,Acetyltransf_10 k59_1270547_1 631362.Thi970DRAFT_04697 1.18e-96 313.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,1RNCU@1236|Gammaproteobacteria,1WWJQ@135613|Chromatiales 135613|Chromatiales L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_971872_1 395495.Lcho_3893 9.02e-65 223.0 COG2132@1|root,COG2132@2|Bacteria,1N9H3@1224|Proteobacteria,2VZQA@28216|Betaproteobacteria,1KNDH@119065|unclassified Burkholderiales 28216|Betaproteobacteria Q Multicopper oxidase - - 1.16.3.3 ko:K22349 - - - - ko00000,ko01000 - - - - k59_287729_1 1205680.CAKO01000040_gene1070 1.32e-92 283.0 COG0683@1|root,COG0683@2|Bacteria,1MWNB@1224|Proteobacteria,2TTAH@28211|Alphaproteobacteria,2JQHT@204441|Rhodospirillales 204441|Rhodospirillales E Receptor family ligand binding region - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_336095_1 1201290.M902_0945 9.13e-28 111.0 COG1108@1|root,COG1108@2|Bacteria,1Q1MX@1224|Proteobacteria,42U0F@68525|delta/epsilon subdivisions 1224|Proteobacteria U ABC 3 transport family - - - ko:K02075 - M00244 - - ko00000,ko00002,ko02000 3.A.1.15 - - ABC-3 k59_503178_1 477228.YO5_16335 9.76e-34 134.0 COG4251@1|root,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,1T1YP@1236|Gammaproteobacteria,1Z0SZ@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria T COG0642 Signal transduction histidine kinase - - - ko:K20971 ko02025,map02025 - - - ko00000,ko00001,ko01001,ko02022 - - - 7TMR-DISMED2,7TMR-DISM_7TM,HATPase_c,HisKA,Response_reg k59_758823_1 1415779.JOMH01000001_gene2583 1.57e-115 347.0 COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,1RMP2@1236|Gammaproteobacteria,1X4TP@135614|Xanthomonadales 135614|Xanthomonadales E Belongs to the IlvD Edd family - - - - - - - - - - - - ILVD_EDD k59_1169443_2 314254.OA2633_11550 1.96e-11 65.9 COG0471@1|root,COG0471@2|Bacteria,1MUSA@1224|Proteobacteria,2TU0C@28211|Alphaproteobacteria,43WQ1@69657|Hyphomonadaceae 28211|Alphaproteobacteria P COG0471 Di- and tricarboxylate transporters - - - ko:K03319,ko:K09477,ko:K11106,ko:K14445 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.47,2.A.47.1,2.A.47.3.2,2.A.47.3.3 - - Na_sulph_symp k59_144153_1 204773.HEAR0408 2.01e-54 185.0 COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,2VHXN@28216|Betaproteobacteria,472W4@75682|Oxalobacteraceae 28216|Betaproteobacteria M Ami_3 amiC - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - AMIN,Amidase_3 k59_657382_2 1096930.L284_17150 1.53e-08 60.5 2ATMD@1|root,31J5V@2|Bacteria,1RH31@1224|Proteobacteria,2UBNT@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Tail tubular protein - - - - - - - - - - - - Tube k59_913769_2 1236959.BAMT01000007_gene2678 1.04e-42 147.0 COG0352@1|root,COG0352@2|Bacteria,1RDSU@1224|Proteobacteria,2VSR5@28216|Betaproteobacteria,2KMSI@206350|Nitrosomonadales 206350|Nitrosomonadales H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) thiE - 2.5.1.3 ko:K00788 ko00730,ko01100,map00730,map01100 M00127 R03223,R10712 RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 - - - TMP-TENI k59_619630_1 1229205.BUPH_00622 1.18e-147 428.0 COG4638@1|root,COG4638@2|Bacteria,1MX47@1224|Proteobacteria,2VJEA@28216|Betaproteobacteria,1KFH9@119060|Burkholderiaceae 28216|Betaproteobacteria P Rieske [2Fe-2S] domain - - - - - - - - - - - - Rieske k59_144206_1 314278.NB231_08127 1.52e-128 404.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,1WVVI@135613|Chromatiales 135613|Chromatiales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_402065_1 1385517.N800_13180 5.82e-05 50.8 COG2373@1|root,COG4932@1|root,COG2373@2|Bacteria,COG4932@2|Bacteria,1QZFW@1224|Proteobacteria 1224|Proteobacteria M domain protein - - - - - - - - - - - - DUF11,SdrD_B k59_1088567_1 1454004.AW11_00272 2.34e-119 360.0 COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,2VIGF@28216|Betaproteobacteria,1KPPG@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria L Single-stranded-DNA-specific exonuclease recJ - - ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 k59_743266_1 1380370.JIBA01000015_gene374 1.03e-62 206.0 COG2114@1|root,COG3437@1|root,COG2114@2|Bacteria,COG3437@2|Bacteria,2GNPX@201174|Actinobacteria,4FFVN@85021|Intrasporangiaceae 201174|Actinobacteria T Adenylyl- / guanylyl cyclase, catalytic domain osaB - - - - - - - - - - - Response_reg k59_998823_1 335283.Neut_0412 6.83e-55 190.0 COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,2VH14@28216|Betaproteobacteria,3722A@32003|Nitrosomonadales 28216|Betaproteobacteria O Heat shock 70 kDa protein dnaK GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0022607,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043531,GO:0043933,GO:0044085,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0070887,GO:0071310,GO:0071840,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141 - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_789677_1 582744.Msip34_1435 2.92e-15 77.4 COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,2VI9F@28216|Betaproteobacteria,2KM6K@206350|Nitrosomonadales 206350|Nitrosomonadales C Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle ppc - 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPcase k59_789677_2 1395571.TMS3_0116350 8.9e-09 55.8 COG2206@1|root,COG2206@2|Bacteria,1MW7F@1224|Proteobacteria,1RPEZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria T COG2206 HD-GYP domain - - - - - - - - - - - - DUF3391,HD,HD_5 k59_363434_1 1123367.C666_11635 4.88e-40 153.0 COG3637@1|root,COG3637@2|Bacteria,1RAS0@1224|Proteobacteria,2WHIG@28216|Betaproteobacteria 28216|Betaproteobacteria M Putative outer membrane beta-barrel porin, MtrB/PioB - - - - - - - - - - - - MtrB_PioB k59_789686_1 296591.Bpro_4149 1.45e-89 288.0 COG0591@1|root,COG0642@1|root,COG0591@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,2VKRS@28216|Betaproteobacteria,4AAXQ@80864|Comamonadaceae 28216|Betaproteobacteria T His Kinase A (phospho-acceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,PAS_7,Response_reg k59_402155_1 1123023.JIAI01000001_gene6352 6.87e-71 226.0 COG4106@1|root,COG4106@2|Bacteria,2I3QF@201174|Actinobacteria,4E20K@85010|Pseudonocardiales 201174|Actinobacteria S O-methyltransferase - - - - - - - - - - - - Methyltransf_31 k59_825907_1 113395.AXAI01000012_gene7060 7.23e-24 97.1 COG0662@1|root,COG0662@2|Bacteria,1RFQ6@1224|Proteobacteria,2U4AV@28211|Alphaproteobacteria,3JWI4@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria G AraC-like ligand binding domain - - - - - - - - - - - - AraC_binding,Cupin_2 k59_825907_2 1123073.KB899241_gene2785 1.87e-54 175.0 COG1490@1|root,COG1490@2|Bacteria,1RGTV@1224|Proteobacteria,1S61I@1236|Gammaproteobacteria,1X6FE@135614|Xanthomonadales 135614|Xanthomonadales J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality dtd GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360 - ko:K07560 - - - - ko00000,ko01000,ko03016 - - - Tyr_Deacylase k59_825907_3 414684.RC1_1851 9.33e-14 67.8 COG5481@1|root,COG5481@2|Bacteria,1NG9U@1224|Proteobacteria,2UFXJ@28211|Alphaproteobacteria,2JU2T@204441|Rhodospirillales 204441|Rhodospirillales S Protein of unknown function (DUF465) - - - - - - - - - - - - DUF465 k59_487612_1 595537.Varpa_5094 1.92e-55 181.0 COG0664@1|root,COG0664@2|Bacteria,1RK3F@1224|Proteobacteria,2VT59@28216|Betaproteobacteria,4AFUR@80864|Comamonadaceae 28216|Betaproteobacteria K PFAM Cyclic nucleotide-binding - - - - - - - - - - - - HTH_Crp_2,cNMP_binding k59_487612_2 1157708.KB907457_gene2572 1.18e-78 243.0 COG0664@1|root,COG0664@2|Bacteria,1RK3F@1224|Proteobacteria,2VT59@28216|Betaproteobacteria,4AFUR@80864|Comamonadaceae 28216|Betaproteobacteria K PFAM Cyclic nucleotide-binding - - - - - - - - - - - - HTH_Crp_2,cNMP_binding k59_1343934_1 713586.KB900536_gene1917 8.58e-106 317.0 COG1850@1|root,COG1850@2|Bacteria,1MWEB@1224|Proteobacteria,1RRMX@1236|Gammaproteobacteria,1WXC1@135613|Chromatiales 135613|Chromatiales G RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site cbbL - 4.1.1.39 ko:K01601 ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200 M00165,M00166,M00532 R00024,R03140 RC00172,RC00859 ko00000,ko00001,ko00002,ko01000 - - - RuBisCO_large,RuBisCO_large_N k59_789740_1 331869.BAL199_19081 2.28e-25 107.0 COG0534@1|root,COG0534@2|Bacteria,1MVRV@1224|Proteobacteria,2TSMQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria V Mate efflux family protein - - - - - - - - - - - - MatE k59_789740_2 1095769.CAHF01000011_gene2561 2.75e-40 143.0 COG2267@1|root,COG2267@2|Bacteria,1Q6AF@1224|Proteobacteria,2VJQ3@28216|Betaproteobacteria,472AB@75682|Oxalobacteraceae 28216|Betaproteobacteria I Serine aminopeptidase, S33 - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_4,Abhydrolase_6,FSH1 k59_65474_1 1380394.JADL01000008_gene3764 4.4e-35 132.0 28PTM@1|root,2ZCEU@2|Bacteria,1R5DD@1224|Proteobacteria,2TVG7@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Family of unknown function (DUF5309) - - - - - - - - - - - - DUF5309 k59_1212355_1 869210.Marky_0766 2.88e-48 164.0 COG1878@1|root,COG1878@2|Bacteria,1WJ7A@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S Putative cyclase - - - - - - - - - - - - Cyclase k59_998971_1 1097668.BYI23_A017400 4.41e-21 92.0 COG0565@1|root,COG0565@2|Bacteria,1N47Y@1224|Proteobacteria,2VI2D@28216|Betaproteobacteria,1K3DI@119060|Burkholderiaceae 28216|Betaproteobacteria J Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA trmJ - - ko:K02533 - - - - ko00000,ko01000,ko03016 - - - SpoU_methylase k59_998971_2 397945.Aave_2076 1.21e-32 120.0 COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,2VH8C@28216|Betaproteobacteria,4AAY0@80864|Comamonadaceae 28216|Betaproteobacteria E TIGRFAM Serine O-acetyltransferase cysE - 2.3.1.30 ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 M00021 R00586 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,SATase_N k59_1169703_1 991905.SL003B_1053 5.58e-147 436.0 COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2TQY9@28211|Alphaproteobacteria,4BR6A@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S TRAP transporter, 4TM 12TM fusion protein - - - - - - - - - - - - DctM k59_101967_1 556268.OFAG_02062 3.25e-56 186.0 COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,2VH91@28216|Betaproteobacteria,472UZ@75682|Oxalobacteraceae 28216|Betaproteobacteria E Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins iscS - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 k59_101967_2 1122134.KB893650_gene1390 7.38e-55 173.0 COG0822@1|root,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,1S3P1@1236|Gammaproteobacteria,1XJSS@135619|Oceanospirillales 135619|Oceanospirillales C A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters - - - ko:K04488 - - - - ko00000 - - - NifU_N k59_1124411_1 948106.AWZT01000003_gene5722 2.52e-89 289.0 COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,2VHUF@28216|Betaproteobacteria,1K0Y7@119060|Burkholderiaceae 28216|Betaproteobacteria L dna topoisomerase III topB - 5.99.1.2 ko:K03169 - - - - ko00000,ko01000,ko03032 - - - SWIB,Topoisom_bac,Toprim,Toprim_Crpt k59_700886_1 1121106.JQKB01000113_gene268 1.3e-93 289.0 COG0154@1|root,COG0154@2|Bacteria,1MW3Z@1224|Proteobacteria,2TS56@28211|Alphaproteobacteria,2JVSZ@204441|Rhodospirillales 204441|Rhodospirillales J Amidase - - - - - - - - - - - - Amidase k59_20818_1 87626.PTD2_21472 3.42e-06 45.1 COG0333@1|root,COG0333@2|Bacteria,1N6RF@1224|Proteobacteria,1SC9G@1236|Gammaproteobacteria,2Q3BJ@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria J Belongs to the bacterial ribosomal protein bL32 family rpmF GO:0000027,GO:0000302,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006950,GO:0006979,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901700,GO:1990904 - ko:K02911 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_L32p k59_20818_2 754476.Q7A_2019 3.55e-06 52.0 COG1399@1|root,COG1399@2|Bacteria,1PGKW@1224|Proteobacteria,1RRK3@1236|Gammaproteobacteria,461EX@72273|Thiotrichales 72273|Thiotrichales S Uncharacterized ACR, COG1399 - - - ko:K07040 - - - - ko00000 - - - DUF177 k59_700899_1 1286093.C266_20614 8.57e-18 87.8 COG2199@1|root,COG2200@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,1RGCV@1224|Proteobacteria,2WGQE@28216|Betaproteobacteria,1KIJZ@119060|Burkholderiaceae 28216|Betaproteobacteria T diguanylate cyclase - - - - - - - - - - - - DUF2222,EAL,GGDEF,HAMP k59_868935_1 497321.C664_07033 1.57e-88 271.0 COG0564@1|root,COG0564@2|Bacteria,1MVDX@1224|Proteobacteria,2VI51@28216|Betaproteobacteria,2KUN8@206389|Rhodocyclales 206389|Rhodocyclales J Responsible for synthesis of pseudouridine from uracil rluC - 5.4.99.24 ko:K06179 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_868935_2 232721.Ajs_3288 2.83e-64 205.0 COG0546@1|root,COG0546@2|Bacteria,1RDA7@1224|Proteobacteria,2VIZ2@28216|Betaproteobacteria,4ABA7@80864|Comamonadaceae 28216|Betaproteobacteria S TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3 ppaX - 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 k59_1169775_2 1125973.JNLC01000014_gene2366 4.29e-24 102.0 COG0683@1|root,COG0683@2|Bacteria,1MVZR@1224|Proteobacteria,2TRRP@28211|Alphaproteobacteria,3JW77@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Periplasmic binding protein domain - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_1296765_1 1158150.KB906245_gene2086 1.53e-48 164.0 COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,1RM8I@1236|Gammaproteobacteria,1WW6U@135613|Chromatiales 135613|Chromatiales G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) tpiA - 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - TIM k59_956548_1 861299.J421_5625 1.45e-41 155.0 COG2010@1|root,COG2133@1|root,COG2010@2|Bacteria,COG2133@2|Bacteria 2|Bacteria G pyrroloquinoline quinone binding - - - - - - - - - - - - Cytochrom_C,Cytochrome_CBB3,GSDH k59_570817_1 1100720.ALKN01000028_gene2452 9.97e-91 280.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VIFS@28216|Betaproteobacteria,4A9PZ@80864|Comamonadaceae 28216|Betaproteobacteria C belongs to the aldehyde dehydrogenase family - - 1.2.1.16,1.2.1.20,1.2.1.3,1.2.1.79 ko:K00128,ko:K00135 ko00010,ko00053,ko00071,ko00250,ko00280,ko00310,ko00330,ko00340,ko00350,ko00380,ko00410,ko00561,ko00620,ko00625,ko00650,ko00760,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00250,map00280,map00310,map00330,map00340,map00350,map00380,map00410,map00561,map00620,map00625,map00650,map00760,map00903,map00981,map01100,map01110,map01120,map01130 M00027,M00135 R00264,R00631,R00710,R00713,R00714,R00904,R01752,R01986,R02401,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_231444_1 1244869.H261_04842 3.54e-152 449.0 COG0318@1|root,COG0318@2|Bacteria,1MUQZ@1224|Proteobacteria,2TRV7@28211|Alphaproteobacteria,2JPYI@204441|Rhodospirillales 204441|Rhodospirillales IQ AMP-binding enzyme - - 6.2.1.34 ko:K12508 - - - - ko00000,ko01000 - - - AMP-binding k59_1124475_1 1038859.AXAU01000001_gene3649 2.21e-123 367.0 COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria,3JTY7@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria Q Tripartite ATP-independent periplasmic transporter, DctM component - - - - - - - - - - - - DctM,DctQ k59_445140_1 381666.H16_A1412 3.28e-71 231.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VJJS@28216|Betaproteobacteria,1K1FF@119060|Burkholderiaceae 28216|Betaproteobacteria I benzoate-CoA ligase bzdA - 6.2.1.25 ko:K04110 ko00362,ko00627,ko01100,ko01120,map00362,map00627,map01100,map01120 - R01422 RC00004,RC00174 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C k59_956569_1 395019.Bmul_0241 8.8e-110 349.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,2VHF3@28216|Betaproteobacteria,1JZZZ@119060|Burkholderiaceae 28216|Betaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_445163_1 1038859.AXAU01000020_gene5511 1.95e-11 64.3 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2TQWP@28211|Alphaproteobacteria,3JW01@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Gamma-glutamyltranspeptidase - - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_445163_2 264198.Reut_A1111 2.74e-139 425.0 COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,2VI3Z@28216|Betaproteobacteria,1K04K@119060|Burkholderiaceae 28216|Betaproteobacteria L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS - - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_231483_1 331869.BAL199_03564 1.65e-120 357.0 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQNK@28211|Alphaproteobacteria,4BR75@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria G COG1593 TRAP-type C4-dicarboxylate transport system, large permease component - - - - - - - - - - - - DctM k59_1124536_1 1123393.KB891326_gene78 0.000423 45.1 COG0589@1|root,COG0589@2|Bacteria,1N8R6@1224|Proteobacteria,2W32Q@28216|Betaproteobacteria 28216|Betaproteobacteria T PFAM UspA - - - - - - - - - - - - - k59_1124536_2 580332.Slit_1196 6.63e-39 146.0 COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,2VJ54@28216|Betaproteobacteria 28216|Betaproteobacteria O Belongs to the peptidase S16 family - - - - - - - - - - - - AAA_32,Lon_C k59_869019_1 640513.Entas_2627 3.92e-19 85.9 COG1752@1|root,COG1752@2|Bacteria,1R4TX@1224|Proteobacteria,1RP66@1236|Gammaproteobacteria 1236|Gammaproteobacteria I esterase of the alpha-beta hydrolase superfamily rssA - - ko:K07001 - - - - ko00000 - - - Patatin k59_1258469_1 335543.Sfum_3501 4.84e-56 190.0 COG2271@1|root,COG2271@2|Bacteria,1QXP5@1224|Proteobacteria,43C51@68525|delta/epsilon subdivisions,2X7FD@28221|Deltaproteobacteria,2MR8I@213462|Syntrophobacterales 28221|Deltaproteobacteria G PFAM Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_1300170_1 991905.SL003B_2531 5.77e-96 303.0 COG1129@1|root,COG4177@1|root,COG1129@2|Bacteria,COG4177@2|Bacteria,1R9IW@1224|Proteobacteria,2TWGB@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Belongs to the binding-protein-dependent transport system permease family - - - ko:K01995,ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C,BPD_transp_2 k59_533736_1 1123393.KB891327_gene376 1.52e-60 187.0 COG0838@1|root,COG0838@2|Bacteria,1RGUT@1224|Proteobacteria,2VSI3@28216|Betaproteobacteria,1KT17@119069|Hydrogenophilales 119069|Hydrogenophilales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoA - 1.6.5.3 ko:K00330 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q4 k59_533736_2 1097668.BYI23_A017000 9.69e-47 153.0 COG0377@1|root,COG0377@2|Bacteria,1MUI2@1224|Proteobacteria,2VIWK@28216|Betaproteobacteria,1K10B@119060|Burkholderiaceae 28216|Betaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoB - 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q6 k59_1300201_1 497321.C664_10842 4.09e-62 199.0 COG0501@1|root,COG0501@2|Bacteria,1MUNA@1224|Proteobacteria,2VHTB@28216|Betaproteobacteria,2KVMZ@206389|Rhodocyclales 206389|Rhodocyclales O Peptidase M48 - - - - - - - - - - - - Peptidase_M48 k59_1300214_1 864073.HFRIS_023372 6.54e-24 98.6 COG1354@1|root,COG1354@2|Bacteria,1MVCN@1224|Proteobacteria,2VKE7@28216|Betaproteobacteria,473K8@75682|Oxalobacteraceae 28216|Betaproteobacteria D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves scpA - - ko:K05896 - - - - ko00000,ko03036 - - - SMC_ScpA k59_1300214_2 391038.Bphy_1733 2.7e-72 228.0 COG1386@1|root,COG1386@2|Bacteria,1PUA6@1224|Proteobacteria,2VKIN@28216|Betaproteobacteria,1K1RS@119060|Burkholderiaceae 28216|Betaproteobacteria D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves scpB - - ko:K06024 - - - - ko00000,ko03036 - - - SMC_ScpB k59_367381_1 582744.Msip34_1817 2.81e-93 298.0 COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,2VI3Z@28216|Betaproteobacteria,2KKXU@206350|Nitrosomonadales 206350|Nitrosomonadales L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS - - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_1002359_1 1100721.ALKO01000003_gene2208 6.73e-47 158.0 COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,2VIHE@28216|Betaproteobacteria,4ABQ3@80864|Comamonadaceae 28216|Betaproteobacteria I Enoyl- acyl-carrier-protein reductase NADH fabI - 1.3.1.10,1.3.1.9 ko:K00208 ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212 M00083,M00572 R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671 RC00052,RC00076,RC00120 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_1002359_2 365046.Rta_34780 2.84e-26 105.0 COG3181@1|root,COG3181@2|Bacteria,1P88K@1224|Proteobacteria,2VJJP@28216|Betaproteobacteria,4AJD9@80864|Comamonadaceae 28216|Betaproteobacteria S Tripartite tricarboxylate transporter family receptor - - - - - - - - - - - - TctC k59_871965_1 1110502.TMO_0092 4.42e-21 85.9 COG2350@1|root,COG2350@2|Bacteria,1MZ9Z@1224|Proteobacteria,2UF4X@28211|Alphaproteobacteria,2JTUA@204441|Rhodospirillales 204441|Rhodospirillales S Protein conserved in bacteria - - - ko:K09780 - - - - ko00000 - - - YCII k59_871965_2 1122135.KB893169_gene2572 2.96e-38 139.0 COG2223@1|root,COG2223@2|Bacteria,1QVKP@1224|Proteobacteria,2TRVV@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_533823_1 977880.RALTA_A0108 2.85e-38 135.0 COG0789@1|root,COG0789@2|Bacteria,1RITY@1224|Proteobacteria,2VSPA@28216|Betaproteobacteria,1K6Y3@119060|Burkholderiaceae 28216|Betaproteobacteria K Transcriptional regulator zntR - - - - - - - - - - - MerR,MerR-DNA-bind,MerR_1 k59_704365_1 1268239.PALB_29840 1.32e-33 129.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,2Q0X3@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria V COG0841 Cation multidrug efflux pump - - - ko:K03296,ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_704365_2 697282.Mettu_3716 1.63e-65 215.0 COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,1RPI1@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family acrA - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - Biotin_lipoyl_2,HlyD_D23 k59_1347949_1 1187851.A33M_0281 1.8e-20 87.4 COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2TR61@28211|Alphaproteobacteria,3FD1Y@34008|Rhodovulum 28211|Alphaproteobacteria E ATPases associated with a variety of cellular activities - - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran k59_1347949_2 381666.H16_A0423 9.32e-20 88.6 COG0845@1|root,COG0845@2|Bacteria,1R3U4@1224|Proteobacteria,2VNQ2@28216|Betaproteobacteria,1K0P5@119060|Burkholderiaceae 28216|Betaproteobacteria M Secretion protein - - - ko:K01993 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3 k59_192718_1 1089552.KI911559_gene491 1.25e-68 216.0 COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,2TQMN@28211|Alphaproteobacteria,2JPN3@204441|Rhodospirillales 204441|Rhodospirillales P Plays a role in the regulation of phosphate uptake phoU - - ko:K02039 - - - - ko00000 - - - PhoU k59_533849_1 1238182.C882_1019 8.36e-56 178.0 COG0139@1|root,COG0139@2|Bacteria,1MW67@1224|Proteobacteria,2UCKH@28211|Alphaproteobacteria,2JSR5@204441|Rhodospirillales 204441|Rhodospirillales E Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP hisI - 3.5.4.19 ko:K01496 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04037 RC01055 ko00000,ko00001,ko00002,ko01000 - - - PRA-CH k59_533849_2 1535287.JP74_14475 2.61e-15 75.9 COG0626@1|root,COG0626@2|Bacteria,1MU9E@1224|Proteobacteria,2TS8Z@28211|Alphaproteobacteria,3N67U@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria E cystathionine beta-lyase metC - 4.4.1.8 ko:K01760 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 M00017 R00782,R01286,R02408,R04941 RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303 ko00000,ko00001,ko00002,ko01000 - - - Cys_Met_Meta_PP k59_491197_1 1031711.RSPO_c01176 7.82e-102 308.0 COG2057@1|root,COG2057@2|Bacteria,1MWW1@1224|Proteobacteria,2VIBE@28216|Betaproteobacteria,1K086@119060|Burkholderiaceae 28216|Betaproteobacteria I TIGRFAM 3-oxoacid CoA-transferase, B subunit pcaJ - 2.8.3.6 ko:K01032 ko00362,ko01100,ko01120,map00362,map01100,map01120 - R02990 RC00014 ko00000,ko00001,ko01000 - - - CoA_trans k59_367493_1 1082933.MEA186_30901 5.02e-48 181.0 COG1572@1|root,COG2931@1|root,COG3210@1|root,COG4070@1|root,COG1572@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4070@2|Bacteria,1MU7T@1224|Proteobacteria 1224|Proteobacteria Q COG2931, RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - Autotransporter,Cadherin-like,Calx-beta,DUF4347,He_PIG k59_69491_1 1349767.GJA_1325 3.53e-67 226.0 COG4796@1|root,COG4796@2|Bacteria,1QUY7@1224|Proteobacteria,2VJ8Z@28216|Betaproteobacteria 28216|Betaproteobacteria U type II and III secretion system protein - - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Cohesin,STN,Secretin,Secretin_N k59_491236_2 1132855.KB913035_gene238 2.66e-72 233.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2VHES@28216|Betaproteobacteria,2KNFK@206350|Nitrosomonadales 206350|Nitrosomonadales S ABC transporter - - 3.6.3.25 ko:K06020 - - - - ko00000,ko01000 - - - ABC_tran,ABC_tran_Xtn k59_1173272_1 1454004.AW11_02855 1.1e-97 298.0 COG0651@1|root,COG0651@2|Bacteria,1QU5Z@1224|Proteobacteria,2VPQP@28216|Betaproteobacteria 28216|Betaproteobacteria CP Proton-conducting membrane transporter - - - - - - - - - - - - Proton_antipo_M,Proton_antipo_N k59_960048_1 1535422.ND16A_1814 3.9e-53 189.0 COG2132@1|root,COG2132@2|Bacteria,1PM6Q@1224|Proteobacteria,1RRZJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Parallel beta-helix repeats - - - - - - - - - - - - Cu-oxidase_3 k59_960059_1 375286.mma_2347 5.56e-89 272.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VHB0@28216|Betaproteobacteria,476TX@75682|Oxalobacteraceae 28216|Betaproteobacteria H CoA-transferase family III - - 2.8.3.16,2.8.3.22 ko:K07749,ko:K14471,ko:K14472 ko00660,ko00720,ko01120,ko01200,map00660,map00720,map01120,map01200 M00376 R00406,R03154 RC00014 ko00000,ko00001,ko00002,ko01000 - - - CoA_transf_3 k59_863169_1 264730.PSPPH_3613 6.45e-45 164.0 COG0607@1|root,COG2897@1|root,COG0607@2|Bacteria,COG2897@2|Bacteria,1MU3V@1224|Proteobacteria,1RQD0@1236|Gammaproteobacteria,1Z4XY@136849|Pseudomonas syringae group 1236|Gammaproteobacteria P Rhodanese Homology Domain - - - - - - - - - - - - Rhodanese k59_1335693_1 94624.Bpet0399 3.3e-105 310.0 COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,2VJ4K@28216|Betaproteobacteria,3T25K@506|Alcaligenaceae 28216|Betaproteobacteria C Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family - - 1.3.5.4 ko:K00245 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00150,M00173 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - Fer2_3,Fer4_17,Fer4_8 k59_1335693_2 1286631.X805_08590 3.6e-13 68.2 COG0596@1|root,COG0596@2|Bacteria,1R3U1@1224|Proteobacteria,2VNZR@28216|Betaproteobacteria,1KKK6@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Alpha/beta hydrolase family - - - - - - - - - - - - Abhydrolase_6 k59_651338_1 1144310.PMI07_001936 4.73e-22 95.1 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TSTW@28211|Alphaproteobacteria,4BDR1@82115|Rhizobiaceae 28211|Alphaproteobacteria EH Thiamine pyrophosphate enzyme, central domain - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_651338_2 1207063.P24_00370 6.68e-48 166.0 COG0346@1|root,COG0346@2|Bacteria,1RDDN@1224|Proteobacteria,2U7MP@28211|Alphaproteobacteria,2JV0I@204441|Rhodospirillales 204441|Rhodospirillales E Glyoxalase-like domain - - - - - - - - - - - - Glyoxalase_3 k59_14095_1 1288484.APCS01000063_gene2921 2.21e-42 158.0 COG0515@1|root,COG3103@1|root,COG3420@1|root,COG0515@2|Bacteria,COG3103@2|Bacteria,COG3420@2|Bacteria,1WMF0@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus KLT Protein tyrosine kinase - - - - - - - - - - - - Pkinase k59_907370_1 1122611.KB903949_gene6510 7.41e-50 169.0 COG4221@1|root,COG4221@2|Bacteria,2GN3I@201174|Actinobacteria,4EI20@85012|Streptosporangiales 201174|Actinobacteria S KR domain - - - - - - - - - - - - adh_short k59_395594_1 398580.Dshi_2583 5.61e-12 60.8 COG0227@1|root,COG0227@2|Bacteria,1MZ57@1224|Proteobacteria,2UBQU@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Belongs to the bacterial ribosomal protein bL28 family rpmB GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02902 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L28 k59_395594_2 398525.KB900701_gene1496 1.87e-26 102.0 COG3631@1|root,COG3631@2|Bacteria,1P5A2@1224|Proteobacteria,2TV5B@28211|Alphaproteobacteria,3JR2U@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S SnoaL-like domain MA20_24415 - - - - - - - - - - - SnoaL_2 k59_355425_1 1286093.C266_18681 1.75e-24 96.3 COG0394@1|root,COG0394@2|Bacteria,1RH90@1224|Proteobacteria,2VSKW@28216|Betaproteobacteria,1K57G@119060|Burkholderiaceae 28216|Betaproteobacteria T Low molecular weight phosphotyrosine protein phosphatase ptpA GO:0000271,GO:0003674,GO:0003824,GO:0004721,GO:0004725,GO:0005975,GO:0005976,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009242,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0033692,GO:0034637,GO:0034645,GO:0035335,GO:0036211,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044267,GO:0046377,GO:0071704,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901576 3.1.3.48 ko:K01104 - - - - ko00000,ko01000 - - - LMWPc k59_355425_2 1432050.IE4771_CH01285 4.74e-49 164.0 COG2010@1|root,COG2010@2|Bacteria,1MV6D@1224|Proteobacteria,2TT9U@28211|Alphaproteobacteria,4BAVA@82115|Rhizobiaceae 28211|Alphaproteobacteria C Cytochrome c, mono- and diheme variants cycG GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - Cytochrom_C k59_992550_1 454957.IA64_12045 1.85e-09 57.4 COG0177@1|root,COG0177@2|Bacteria,1MUYQ@1224|Proteobacteria,1RMHU@1236|Gammaproteobacteria,1X340@135614|Xanthomonadales 135614|Xanthomonadales L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate nth - 4.2.99.18 ko:K10773 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD k59_992550_2 998674.ATTE01000001_gene757 3.2e-44 153.0 COG4660@1|root,COG4660@2|Bacteria,1MW6N@1224|Proteobacteria,1RMEH@1236|Gammaproteobacteria,45ZVS@72273|Thiotrichales 72273|Thiotrichales C Part of a membrane complex involved in electron transport - - - ko:K03613 - - - - ko00000 - - - Rnf-Nqr k59_820444_1 204773.HEAR1194 6.82e-54 176.0 COG2010@1|root,COG2010@2|Bacteria,1P1GY@1224|Proteobacteria,2VP4W@28216|Betaproteobacteria,475FZ@75682|Oxalobacteraceae 28216|Betaproteobacteria C Cytochrome c soxX - - ko:K17223 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - Cytochrom_C k59_781758_1 391625.PPSIR1_17140 1.51e-56 191.0 COG3464@1|root,COG3464@2|Bacteria,1MV5J@1224|Proteobacteria,42M93@68525|delta/epsilon subdivisions,2WK5I@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM Transposase, IS204 IS1001 IS1096 IS1165 - - - ko:K07485 - - - - ko00000 - - - DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3 k59_138722_1 1000565.METUNv1_03998 1.22e-33 134.0 COG1807@1|root,COG1807@2|Bacteria,1P6JE@1224|Proteobacteria,2VJS8@28216|Betaproteobacteria 28216|Betaproteobacteria M Dolichyl-phosphate-mannose-protein mannosyltransferase - - - - - - - - - - - - PMT_2 k59_313693_1 1283300.ATXB01000001_gene1301 5.64e-05 44.7 COG1952@1|root,COG1952@2|Bacteria,1RI75@1224|Proteobacteria,1S62H@1236|Gammaproteobacteria,1XEZ2@135618|Methylococcales 135618|Methylococcales U One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA secB - - ko:K03071 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03110 3.A.5 - - SecB k59_313693_2 717785.HYPMC_4433 1.14e-19 84.0 COG0695@1|root,COG0695@2|Bacteria,1N72P@1224|Proteobacteria,2UFM1@28211|Alphaproteobacteria,3N774@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria O Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins grxC - - ko:K03676 - - - - ko00000,ko03110 - - - Glutaredoxin k59_225220_1 557599.MKAN_19100 1.03e-22 90.9 COG2346@1|root,COG2346@2|Bacteria,2IFYB@201174|Actinobacteria,23E5N@1762|Mycobacteriaceae 201174|Actinobacteria S Bacterial-like globin - - - ko:K06886 - - - - ko00000 - - - Bac_globin k59_225220_2 1429916.X566_17260 1.01e-32 121.0 COG3217@1|root,COG3217@2|Bacteria 2|Bacteria S molybdenum ion binding - - - ko:K07140 - - - - ko00000 - - - MOSC,MOSC_N k59_96320_1 497321.C664_02720 6.3e-148 447.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,2VI4A@28216|Betaproteobacteria,2KUXH@206389|Rhodocyclales 206389|Rhodocyclales EF Belongs to the CarB family carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_992663_1 640081.Dsui_0408 4.48e-146 449.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHZQ@28216|Betaproteobacteria,2KUT5@206389|Rhodocyclales 206389|Rhodocyclales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K18303 - M00642 - - ko00000,ko00002,ko01504,ko02000 2.A.6.2.17 - - ACR_tran k59_612101_1 640511.BC1002_1033 7.86e-146 431.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VIP3@28216|Betaproteobacteria,1K0R8@119060|Burkholderiaceae 28216|Betaproteobacteria F Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_612101_2 1265502.KB905936_gene2684 9.41e-19 82.8 COG2862@1|root,COG2862@2|Bacteria,1RANN@1224|Proteobacteria,2VK3P@28216|Betaproteobacteria,4A9XY@80864|Comamonadaceae 28216|Betaproteobacteria S UPF0114 protein - - - - - - - - - - - - UPF0114 k59_1248645_1 566466.NOR53_1136 6.15e-23 96.7 COG2010@1|root,COG2010@2|Bacteria,1MUCW@1224|Proteobacteria,1RPYJ@1236|Gammaproteobacteria,1J545@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex ccoP - - ko:K00406 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - iJN746.PP_4253 Cytochrome_CBB3,FixP_N k59_266822_1 1238182.C882_3506 1.42e-66 225.0 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria,2JQ9H@204441|Rhodospirillales 204441|Rhodospirillales C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - 1.2.5.3 ko:K03520 - - R11168 RC02800 ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_907550_1 331869.BAL199_26227 1.07e-101 308.0 COG0683@1|root,COG0683@2|Bacteria,1MVZR@1224|Proteobacteria,2TRRP@28211|Alphaproteobacteria,4BRXD@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_737046_1 1123060.JONP01000011_gene3108 9.3e-62 205.0 COG3540@1|root,COG3540@2|Bacteria,1MWAF@1224|Proteobacteria,2TS7J@28211|Alphaproteobacteria,2JQWQ@204441|Rhodospirillales 204441|Rhodospirillales P PhoD-like phosphatase, N-terminal domain - - 3.1.3.1 ko:K01113 ko00790,ko01100,ko02020,map00790,map01100,map02020 M00126 R04620 RC00017 ko00000,ko00001,ko00002,ko01000 - - - PhoD,PhoD_N k59_1290694_1 873513.HMPREF6485_0829 2.17e-38 146.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,4NEP3@976|Bacteroidetes,2FN08@200643|Bacteroidia 976|Bacteroidetes C 2-oxoacid acceptor oxidoreductase, alpha subunit porA - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N k59_438674_2 1000565.METUNv1_03014 7.57e-05 45.8 COG3245@1|root,COG3245@2|Bacteria,1MZBZ@1224|Proteobacteria,2VMBB@28216|Betaproteobacteria,2KWMI@206389|Rhodocyclales 206389|Rhodocyclales C cytochrome c5 - - - - - - - - - - - - Cytochrome_CBB3 k59_1118999_1 1280673.AUJJ01000010_gene2416 1.22e-07 58.5 COG2267@1|root,COG2267@2|Bacteria,1TPI0@1239|Firmicutes,247QR@186801|Clostridia,4BWW4@830|Butyrivibrio 186801|Clostridia I Alpha/beta hydrolase family - - 1.11.1.10,3.1.1.24 ko:K00433,ko:K01055 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00568 R02991 RC00825 ko00000,ko00001,ko00002,ko01000 - - - Abhydrolase_1,Abhydrolase_4 k59_1248691_1 337191.KTR9_0268 8.45e-13 73.2 COG0747@1|root,COG0747@2|Bacteria,2GJ4B@201174|Actinobacteria,4GBUZ@85026|Gordoniaceae 201174|Actinobacteria E Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_1248699_1 113395.AXAI01000002_gene5219 4.55e-39 157.0 COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TTJ0@28211|Alphaproteobacteria,3JS5D@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - GAF,GAF_2,HAMP,HATPase_c,HisKA,PAS_7,dCache_1 k59_781980_1 1123060.JONP01000014_gene4096 2.91e-80 248.0 COG0596@1|root,COG0596@2|Bacteria,1MUVB@1224|Proteobacteria,2TREP@28211|Alphaproteobacteria,2JPSQ@204441|Rhodospirillales 204441|Rhodospirillales S Alpha/beta hydrolase family - - 3.8.1.3 ko:K01561 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 - R05287 RC00697 ko00000,ko00001,ko01000 - - - Abhydrolase_1 k59_524039_2 305700.B447_06592 3.9e-67 206.0 COG0607@1|root,COG0607@2|Bacteria,1REHH@1224|Proteobacteria,2VTFS@28216|Betaproteobacteria,2KWUC@206389|Rhodocyclales 206389|Rhodocyclales P Rhodanese Homology Domain - - - - - - - - - - - - Rhodanese k59_524039_3 1348657.M622_00925 1.17e-06 50.1 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,2VHYQ@28216|Betaproteobacteria,2KUFA@206389|Rhodocyclales 206389|Rhodocyclales H methionine synthase metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_694558_1 1278309.KB907101_gene790 2.38e-40 143.0 COG3622@1|root,COG3622@2|Bacteria,1MV53@1224|Proteobacteria,1RQF9@1236|Gammaproteobacteria,1XI0D@135619|Oceanospirillales 135619|Oceanospirillales G Belongs to the hyi family hyi - 5.3.1.22,5.3.1.35 ko:K01816,ko:K22131 ko00630,ko01100,map00630,map01100 - R01394 RC00511 ko00000,ko00001,ko01000 - - - AP_endonuc_2 k59_612252_2 85643.Tmz1t_1089 3.61e-30 119.0 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,2VI01@28216|Betaproteobacteria,2KU9I@206389|Rhodocyclales 206389|Rhodocyclales E Aminotransferase - - - - - - - - - - - - Aminotran_1_2 k59_1206060_1 998088.B565_1018 4.85e-37 135.0 COG1168@1|root,COG1168@2|Bacteria,1MY33@1224|Proteobacteria,1RP58@1236|Gammaproteobacteria,1Y44W@135624|Aeromonadales 135624|Aeromonadales E Aminotransferase class I and II - - 4.4.1.8 ko:K14155 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 - R00782,R01286,R02408,R04941 RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_1206060_2 1380394.JADL01000002_gene1281 9.64e-87 263.0 COG0491@1|root,COG0491@2|Bacteria,1MUT2@1224|Proteobacteria,2TRG9@28211|Alphaproteobacteria,2JQV5@204441|Rhodospirillales 204441|Rhodospirillales S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_96456_1 557598.LHK_00090 1.17e-50 179.0 COG0557@1|root,COG0557@2|Bacteria,1NGSQ@1224|Proteobacteria,2VHMM@28216|Betaproteobacteria,2KPKK@206351|Neisseriales 206351|Neisseriales K RNB-like protein - - 3.1.13.1 ko:K01147 - - - - ko00000,ko01000,ko03016 - - - RNB k59_737147_1 794903.OPIT5_23580 4.05e-48 164.0 COG0667@1|root,COG0667@2|Bacteria,46SC2@74201|Verrucomicrobia,3K7X7@414999|Opitutae 414999|Opitutae C aldo keto reductase - - - - - - - - - - - - Aldo_ket_red k59_737147_2 204773.HEAR1757 2.46e-15 76.6 COG1232@1|root,COG1232@2|Bacteria,1NQUH@1224|Proteobacteria,2VJV1@28216|Betaproteobacteria,472Y4@75682|Oxalobacteraceae 28216|Betaproteobacteria H Flavin containing amine oxidoreductase hpnE - 1.17.8.1 ko:K21677 - - - - ko00000,ko01000 - - - Amino_oxidase k59_266929_1 887898.HMPREF0551_0218 3.88e-81 250.0 COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,2VHHG@28216|Betaproteobacteria,1K1MS@119060|Burkholderiaceae 28216|Betaproteobacteria C Belongs to the glyceraldehyde-3-phosphate dehydrogenase family gap GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_313945_1 748280.NH8B_0461 1.89e-52 179.0 COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,2VH37@28216|Betaproteobacteria,2KPZB@206351|Neisseriales 206351|Neisseriales C FAD dependent oxidoreductase - - 1.5.5.1 ko:K00311 - - - - ko00000,ko01000 - - - ETF_QO,FAD_binding_2,NAD_binding_8 k59_313945_2 690597.JH730983_gene221 2.78e-23 91.7 COG4323@1|root,COG4323@2|Bacteria,1N16T@1224|Proteobacteria,1S8V6@1236|Gammaproteobacteria,1YQJ8@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria S Protein of unknown function (DUF962) - - - - - - - - - - - - DUF962 k59_1336141_1 1157708.KB907450_gene6512 0.000346 42.0 COG5285@1|root,COG5285@2|Bacteria,1MWD5@1224|Proteobacteria,2VM24@28216|Betaproteobacteria,4ABN5@80864|Comamonadaceae 28216|Betaproteobacteria Q Phytanoyl-CoA dioxygenase (PhyH) - - 1.14.11.55 ko:K10674 ko00260,ko01120,map00260,map01120 - R08050 RC00661 ko00000,ko00001,ko01000 - - - PhyH k59_1341255_1 1254432.SCE1572_40910 2.87e-70 222.0 COG0583@1|root,COG0583@2|Bacteria,1MUNN@1224|Proteobacteria,433UM@68525|delta/epsilon subdivisions,2XA3W@28221|Deltaproteobacteria,2YWAZ@29|Myxococcales 28221|Deltaproteobacteria K Transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate k59_741246_1 269799.Gmet_2185 4.53e-36 141.0 COG2010@1|root,COG4733@1|root,COG2010@2|Bacteria,COG4733@2|Bacteria,1N010@1224|Proteobacteria,42M7U@68525|delta/epsilon subdivisions,2WRUR@28221|Deltaproteobacteria 28221|Deltaproteobacteria M PFAM Fibronectin, type III domain - - - - - - - - - - - - fn3 k59_787145_1 296591.Bpro_3143 3.83e-105 309.0 COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,2VHXJ@28216|Betaproteobacteria,4ABCD@80864|Comamonadaceae 28216|Betaproteobacteria C Electron transfer flavoprotein etfB - - ko:K03521 - - - - ko00000 - - - ETF k59_698709_2 883080.HMPREF9697_01895 4.36e-06 47.4 COG1917@1|root,COG1917@2|Bacteria,1RH65@1224|Proteobacteria,2U9S7@28211|Alphaproteobacteria,3K4CC@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Cupin - - - - - - - - - - - - Cupin_2 k59_1252930_1 1123060.JONP01000023_gene2651 8.34e-56 185.0 COG0119@1|root,COG0119@2|Bacteria,1MUMX@1224|Proteobacteria,2TSFX@28211|Alphaproteobacteria 28211|Alphaproteobacteria E HMGL-like - - - - - - - - - - - - HMGL-like k59_1294660_1 883080.HMPREF9697_03076 1.52e-40 144.0 COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,2TSBB@28211|Alphaproteobacteria,3K3D5@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria CE Isocitrate/isopropylmalate dehydrogenase - - 1.1.1.83,1.1.1.93,4.1.1.73 ko:K07246 ko00630,ko00650,map00630,map00650 - R00215,R01751,R02545,R06180 RC00084,RC00105,RC00594 ko00000,ko00001,ko01000 - - - Iso_dh k59_1294660_2 929556.Solca_4105 3.47e-26 105.0 COG2133@1|root,COG2133@2|Bacteria,4NF0B@976|Bacteroidetes,1IPCH@117747|Sphingobacteriia 976|Bacteroidetes G Glucose / Sorbosone dehydrogenase - - - - - - - - - - - - CBM_6,GSDH,Ig_2,Malectin,PKD,VCBS,fn3 k59_528211_2 1005048.CFU_2105 4.48e-62 195.0 COG3791@1|root,COG3791@2|Bacteria,1N6S5@1224|Proteobacteria,2WA8G@28216|Betaproteobacteria,4755A@75682|Oxalobacteraceae 28216|Betaproteobacteria S Glutathione-dependent formaldehyde-activating enzyme - - - - - - - - - - - - GFA k59_100105_1 1158150.KB906246_gene1915 2.55e-56 199.0 COG0243@1|root,COG0243@2|Bacteria,1NSXR@1224|Proteobacteria,1T2GI@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.7.5.1,1.8.5.3 ko:K00370,ko:K07306,ko:K17050 ko00910,ko00920,ko01120,ko02020,map00910,map00920,map01120,map02020 M00529,M00530,M00804 R00798,R01106,R09497,R09501 RC02555,RC02812 ko00000,ko00001,ko00002,ko01000,ko02000 5.A.3.1,5.A.3.3,5.A.3.8 - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal k59_318990_1 876269.ARWA01000001_gene647 2.94e-75 234.0 COG2041@1|root,COG2041@2|Bacteria,1MUW0@1224|Proteobacteria,2TS40@28211|Alphaproteobacteria,3N9TG@45404|Beijerinckiaceae 28211|Alphaproteobacteria S Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide msrP - - ko:K07147 - - - - ko00000,ko01000 - - - Oxidored_molyb k59_655607_1 9031.ENSGALP00000001068 3.26e-14 78.2 COG0659@1|root,KOG0236@2759|Eukaryota,38QA6@33154|Opisthokonta,3BHF9@33208|Metazoa,3CZW6@33213|Bilateria,48A5M@7711|Chordata,48Z39@7742|Vertebrata,4GIK7@8782|Aves 33208|Metazoa P DIDS- and thiosulfate- sensitive anion exchanger mediating chloride, sulfate and oxalate transport SLC26A9 GO:0003674,GO:0005215,GO:0005216,GO:0005253,GO:0005254,GO:0005310,GO:0005342,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006821,GO:0006835,GO:0006873,GO:0006885,GO:0008150,GO:0008272,GO:0008509,GO:0008514,GO:0009893,GO:0009986,GO:0009987,GO:0010468,GO:0010604,GO:0010628,GO:0015075,GO:0015103,GO:0015106,GO:0015108,GO:0015116,GO:0015267,GO:0015291,GO:0015297,GO:0015301,GO:0015318,GO:0015698,GO:0015701,GO:0015711,GO:0015849,GO:0016020,GO:0016021,GO:0016324,GO:0019222,GO:0019531,GO:0019532,GO:0019725,GO:0019899,GO:0022803,GO:0022804,GO:0022838,GO:0022857,GO:0030003,GO:0030004,GO:0030641,GO:0031224,GO:0031226,GO:0034220,GO:0042391,GO:0042592,GO:0044425,GO:0044459,GO:0044464,GO:0045177,GO:0046942,GO:0046943,GO:0048518,GO:0048878,GO:0050789,GO:0050801,GO:0051117,GO:0051179,GO:0051234,GO:0051453,GO:0055067,GO:0055080,GO:0055082,GO:0055085,GO:0060255,GO:0065007,GO:0065008,GO:0071702,GO:0071944,GO:0072348,GO:0098590,GO:0098656,GO:0098660,GO:0098661,GO:0098771,GO:0099516,GO:1901682,GO:1902358,GO:1902476,GO:1903825,GO:1905039 - ko:K14706 ko04978,map04978 - - - ko00000,ko00001,ko02000 2.A.53.2.10 - - STAS,Sulfate_transp k59_741349_1 1380394.JADL01000017_gene507 1.72e-93 287.0 COG0683@1|root,COG0683@2|Bacteria,1MVV2@1224|Proteobacteria,2TRFU@28211|Alphaproteobacteria,2JQ96@204441|Rhodospirillales 204441|Rhodospirillales E COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_360969_1 555779.Dthio_PD1478 6.05e-19 85.5 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,42WT2@68525|delta/epsilon subdivisions,2WR9X@28221|Deltaproteobacteria,2MAU1@213115|Desulfovibrionales 28221|Deltaproteobacteria L PFAM transposase IS116 IS110 IS902 family protein - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_617395_1 243233.MCA2039 1.19e-147 457.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1XEDS@135618|Methylococcales 135618|Methylococcales E Glutamate synthase gltB - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_1122651_1 439235.Dalk_4509 3.82e-77 241.0 COG3677@1|root,COG3677@2|Bacteria,1MXYX@1224|Proteobacteria,434AT@68525|delta/epsilon subdivisions,2X9GM@28221|Deltaproteobacteria,2MNQ4@213118|Desulfobacterales 28221|Deltaproteobacteria L ISXO2-like transposase domain - - - - - - - - - - - - DDE_Tnp_IS1595,Zn_Tnp_IS1595 k59_361023_1 1232410.KI421418_gene2244 1.09e-40 155.0 COG2982@1|root,COG2982@2|Bacteria,1MUME@1224|Proteobacteria,42M50@68525|delta/epsilon subdivisions,2WIP4@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Domain of Unknown Function (DUF748) - - - - - - - - - - - - DUF748 k59_443002_1 76114.ebA2152 9.84e-37 138.0 COG0421@1|root,COG1586@1|root,COG0421@2|Bacteria,COG1586@2|Bacteria,1MVV5@1224|Proteobacteria,2WGFP@28216|Betaproteobacteria,2KUTH@206389|Rhodocyclales 206389|Rhodocyclales E Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine speE - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synth k59_443002_2 1304883.KI912532_gene2454 1.34e-79 249.0 COG2816@1|root,COG2816@2|Bacteria,1QGCX@1224|Proteobacteria,2VQIR@28216|Betaproteobacteria,2KW28@206389|Rhodocyclales 206389|Rhodocyclales L NADH pyrophosphatase-like rudimentary NUDIX domain - - 3.6.1.22 ko:K03426 ko00760,ko01100,ko04146,map00760,map01100,map04146 - R00103,R03004,R11104 RC00002 ko00000,ko00001,ko01000 - - - NUDIX,NUDIX-like,zf-NADH-PPase k59_443002_3 388051.AUFE01000015_gene5960 2.64e-52 175.0 COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,2VJJH@28216|Betaproteobacteria,1JZPR@119060|Burkholderiaceae 28216|Betaproteobacteria K Transcriptional regulator - - - ko:K21703 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate k59_18710_1 572477.Alvin_1248 2.46e-22 92.8 2CARE@1|root,2Z8Q5@2|Bacteria,1R7S8@1224|Proteobacteria,1RRAH@1236|Gammaproteobacteria,1WW2H@135613|Chromatiales 135613|Chromatiales S TIGRFAM CRISPR-associated protein - - - - - - - - - - - - Cas6 k59_18710_2 2340.JV46_21580 4.08e-77 238.0 COG0457@1|root,COG0457@2|Bacteria,1R85G@1224|Proteobacteria,1S0MD@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - - k59_1294798_1 266117.Rxyl_0110 1.16e-31 120.0 COG2215@1|root,COG2215@2|Bacteria,2HRK4@201174|Actinobacteria,4CTM5@84995|Rubrobacteria 84995|Rubrobacteria S Belongs to the NiCoT transporter (TC 2.A.52) family - - - - - - - - - - - - - k59_1294798_2 469383.Cwoe_2549 1.6e-16 78.2 COG0279@1|root,COG0279@2|Bacteria,2HPYA@201174|Actinobacteria,4CTV4@84995|Rubrobacteria 84995|Rubrobacteria G SIS domain - - 5.3.1.28 ko:K03271 ko00540,ko01100,map00540,map01100 M00064 R05645,R09768,R09769 RC00434 ko00000,ko00001,ko00002,ko01000,ko01005 - - - SIS_2 k59_229445_1 502025.Hoch_0175 3.09e-79 252.0 COG1902@1|root,COG1902@2|Bacteria,1R4A8@1224|Proteobacteria,42YBR@68525|delta/epsilon subdivisions,2WU33@28221|Deltaproteobacteria,2YXDW@29|Myxococcales 28221|Deltaproteobacteria C NADH oxidase - - - - - - - - - - - - Oxidored_FMN k59_698881_1 1247649.D560_3274 9.62e-101 319.0 COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,2VIEJ@28216|Betaproteobacteria,3T1IX@506|Alcaligenaceae 28216|Betaproteobacteria J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1,zf-FPG_IleRS k59_824332_1 1121935.AQXX01000109_gene480 3.75e-86 280.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,1XHSN@135619|Oceanospirillales 135619|Oceanospirillales P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - - ACR_tran k59_528409_1 1218075.BAYA01000008_gene2847 1.23e-05 46.6 COG0457@1|root,COG3914@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria,1MVMG@1224|Proteobacteria,2VH3M@28216|Betaproteobacteria,1K03X@119060|Burkholderiaceae 28216|Betaproteobacteria O Tetratricopeptide TPR_2 repeat protein - - - - - - - - - - - - Glyco_transf_41,SEC-C,TPR_16,TPR_2,TPR_8 k59_528409_3 1245469.S58_25380 0.000206 46.6 COG0457@1|root,COG3914@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria,1MVMG@1224|Proteobacteria,2TRVB@28211|Alphaproteobacteria,3JR8N@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria O Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - Glyco_transf_41,TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_4,TPR_8 k59_569055_1 631454.N177_3957 5.21e-71 238.0 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,2TRY7@28211|Alphaproteobacteria,1JMZX@119043|Rhodobiaceae 28211|Alphaproteobacteria OT Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell glnE GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006521,GO:0008150,GO:0008882,GO:0010565,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0031323,GO:0033238,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0070566,GO:0080090 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_787455_1 977880.RALTA_A1698 7.37e-140 432.0 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,2VJMF@28216|Betaproteobacteria,1K119@119060|Burkholderiaceae 28216|Betaproteobacteria D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_787455_2 426114.THI_2287 8.44e-16 72.4 COG0780@1|root,COG0780@2|Bacteria,1MW0M@1224|Proteobacteria,2W9FK@28216|Betaproteobacteria,1KKMT@119065|unclassified Burkholderiales 28216|Betaproteobacteria H Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) queF - 1.7.1.13 ko:K09457 ko00790,ko01100,map00790,map01100 - R07605 RC01875 ko00000,ko00001,ko01000,ko03016 - - - QueF k59_867257_1 402626.Rpic_3912 2.06e-106 318.0 COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,2VM67@28216|Betaproteobacteria,1K0ID@119060|Burkholderiaceae 28216|Betaproteobacteria Q multicopper oxidase type 3 copA_2 - 1.16.3.3 ko:K22348 - - - - ko00000,ko01000 - - - Cu-oxidase_2,Cu-oxidase_3 k59_698996_1 1380394.JADL01000003_gene5164 1.41e-05 45.8 COG3396@1|root,COG3396@2|Bacteria,1MXUK@1224|Proteobacteria,2TTIG@28211|Alphaproteobacteria 28211|Alphaproteobacteria S benzoyl-CoA oxygenase boxB - 1.14.13.208 ko:K15512 ko00362,map00362 - R09555 RC01739 ko00000,ko00001,ko01000 - - - - k59_617648_1 867900.Celly_2913 1.18e-07 53.9 COG3665@1|root,COG3665@2|Bacteria,4NGIF@976|Bacteroidetes,1HYFG@117743|Flavobacteriia 976|Bacteroidetes S Domain of unknown function (DUF1989) - - - ko:K09967 - - - - ko00000 - - - DUF1989 k59_901826_1 767817.Desgi_1296 1.8e-26 107.0 COG2301@1|root,COG2301@2|Bacteria,1TPDY@1239|Firmicutes,24AIH@186801|Clostridia,260C4@186807|Peptococcaceae 186801|Clostridia G Belongs to the HpcH HpaI aldolase family - - 4.1.3.34 ko:K01644 ko02020,map02020 - R00362 RC00067,RC01118 ko00000,ko00001,ko01000 - - - HpcH_HpaI k59_50480_1 296591.Bpro_0379 6.46e-115 344.0 COG0624@1|root,COG0624@2|Bacteria,1MVUX@1224|Proteobacteria,2VHQ8@28216|Betaproteobacteria,4AAK9@80864|Comamonadaceae 28216|Betaproteobacteria E TIGRFAM amidase, hydantoinase carbamoylase family amaB1 - 3.5.1.6,3.5.1.87 ko:K06016 ko00240,ko01100,map00240,map01100 M00046 R00905,R04666 RC00096 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_1329091_1 1231190.NA8A_17008 4.36e-46 165.0 COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,2TRMX@28211|Alphaproteobacteria,43H5R@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S Peptidase M16 inactive domain MA20_05660 - - ko:K07263,ko:K07623 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_518282_1 1485544.JQKP01000002_gene1453 1.5e-80 263.0 COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,2VH2J@28216|Betaproteobacteria,44V3Z@713636|Nitrosomonadales 28216|Betaproteobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family leuS - 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_348645_2 397287.C807_00223 1.96e-34 134.0 COG0466@1|root,COG0466@2|Bacteria,1TNYG@1239|Firmicutes,247SH@186801|Clostridia,27IWT@186928|unclassified Lachnospiraceae 186801|Clostridia O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_1242902_1 1244869.H261_12431 2.73e-29 110.0 COG1310@1|root,COG1310@2|Bacteria,1NC23@1224|Proteobacteria,2UGM4@28211|Alphaproteobacteria,2JTVQ@204441|Rhodospirillales 204441|Rhodospirillales S metal-dependent protease of the PAD1 JAB1 superfamily - - - - - - - - - - - - Prok-JAB k59_1114134_2 1196323.ALKF01000171_gene714 2.23e-23 97.4 COG3000@1|root,COG3000@2|Bacteria,1V2XN@1239|Firmicutes,4HFS5@91061|Bacilli,26X5T@186822|Paenibacillaceae 91061|Bacilli I Fatty acid hydroxylase superfamily - - - - - - - - - - - - FA_hydroxylase k59_987113_1 1198232.CYCME_0054 5.44e-74 248.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,1RM7J@1236|Gammaproteobacteria,45ZWK@72273|Thiotrichales 72273|Thiotrichales M TIGRFAM penicillin-binding protein, 1A - - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - PCB_OB,Transgly,Transpeptidase k59_1200254_1 648757.Rvan_0035 3.02e-204 572.0 COG1024@1|root,COG1024@2|Bacteria,1QY95@1224|Proteobacteria,2U4PY@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Enoyl-CoA hydratase/isomerase - - 3.7.1.21 ko:K07539 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00541 R05593,R05594,R10696 RC01430,RC01431,RC03237 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_1285238_1 1121943.KB899994_gene906 7e-60 197.0 COG1082@1|root,COG1082@2|Bacteria,1NHXC@1224|Proteobacteria,1RZR5@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Xylose isomerase domain protein TIM barrel - - - - - - - - - - - - AP_endonuc_2 k59_1242963_1 1173027.Mic7113_4161 1.27e-64 226.0 COG2199@1|root,COG2202@1|root,COG5002@1|root,COG2202@2|Bacteria,COG3706@2|Bacteria,COG5002@2|Bacteria,1GQ1T@1117|Cyanobacteria,1HHSH@1150|Oscillatoriales 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS_4,Response_reg k59_433116_1 1123504.JQKD01000054_gene4367 5.43e-44 156.0 COG1712@1|root,COG1712@2|Bacteria,1MX8S@1224|Proteobacteria,2VM6P@28216|Betaproteobacteria,4ABPC@80864|Comamonadaceae 28216|Betaproteobacteria H Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate nadX - 1.4.1.21 ko:K06989 ko00760,ko01100,map00760,map01100 - R07407,R07410 RC02566 ko00000,ko00001,ko01000 - - - DUF108,NAD_binding_3 k59_177351_1 1121033.AUCF01000026_gene2992 6.95e-48 170.0 COG2807@1|root,COG2807@2|Bacteria,1QU85@1224|Proteobacteria,2TXRC@28211|Alphaproteobacteria,2JZ2E@204441|Rhodospirillales 204441|Rhodospirillales P Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_177351_2 1175306.GWL_09940 4.99e-05 45.1 COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,1MUV9@1224|Proteobacteria,2VIP7@28216|Betaproteobacteria,472YG@75682|Oxalobacteraceae 28216|Betaproteobacteria C Catalyzes the reversible hydration of fumarate to (S)- malate fumA - 4.2.1.2 ko:K01676 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - Fumerase,Fumerase_C k59_133910_1 622637.KE124774_gene2611 2.31e-39 132.0 COG2963@1|root,COG2963@2|Bacteria,1RGZ5@1224|Proteobacteria,2UAIS@28211|Alphaproteobacteria,36YR7@31993|Methylocystaceae 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - HTH_Tnp_1 k59_133910_2 1121028.ARQE01000016_gene2619 8.39e-83 251.0 COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,2PK0U@255475|Aurantimonadaceae 28211|Alphaproteobacteria L Integrase core domain - - - - - - - - - - - - HTH_21,rve,rve_3 k59_987175_1 246197.MXAN_3779 2.42e-48 175.0 COG0318@1|root,COG1020@1|root,COG3321@1|root,COG0318@2|Bacteria,COG1020@2|Bacteria,COG3321@2|Bacteria,1MU6G@1224|Proteobacteria 1224|Proteobacteria IQ COG0318, Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - - - - - - - - - - AMP-binding,AMP-binding_C,Acyl_transf_1,Bac_luciferase,Condensation,KAsynt_C_assoc,Ketoacyl-synt_C,Methyltransf_25,PP-binding,Thioesterase,ketoacyl-synt k59_944551_1 404589.Anae109_1104 7.88e-13 72.4 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,42MCT@68525|delta/epsilon subdivisions,2WINW@28221|Deltaproteobacteria,2YU71@29|Myxococcales 28221|Deltaproteobacteria H Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell glnE - 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_433146_1 1005048.CFU_0740 1.15e-128 377.0 COG0277@1|root,COG0277@2|Bacteria,1MVYV@1224|Proteobacteria,2VHUQ@28216|Betaproteobacteria,4725H@75682|Oxalobacteraceae 28216|Betaproteobacteria C FAD binding domain glcE - - ko:K11472 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - FAD_binding_4 k59_1114212_1 1236959.BAMT01000002_gene1812 9.42e-106 348.0 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,2VHY8@28216|Betaproteobacteria,2KKXA@206350|Nitrosomonadales 206350|Nitrosomonadales NU Neisseria PilC beta-propeller domain - - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC k59_1333903_1 426114.THI_0039 4.48e-91 276.0 COG0289@1|root,COG0289@2|Bacteria,1MUCT@1224|Proteobacteria,2VJC3@28216|Betaproteobacteria,1KJ45@119065|unclassified Burkholderiales 28216|Betaproteobacteria E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate dapB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576 1.17.1.8 ko:K00215 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R04198,R04199 RC00478 ko00000,ko00001,ko00002,ko01000 - - - DapB_C,DapB_N k59_437054_1 1294143.H681_04485 6.88e-79 244.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,1RMAQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Transposase - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_181322_1 272558.10173025 3.29e-32 120.0 COG2808@1|root,COG2808@2|Bacteria,1TXED@1239|Firmicutes,4HEZS@91061|Bacilli,1ZDPR@1386|Bacillus 91061|Bacilli K Transcriptional regulator paiB - - ko:K07734 - - - - ko00000,ko03000 - - - FMN_bind_2 k59_181322_2 1121924.ATWH01000010_gene992 0.000321 42.4 COG0245@1|root,COG1211@1|root,COG0245@2|Bacteria,COG1211@2|Bacteria,2II8H@201174|Actinobacteria,4FKMA@85023|Microbacteriaceae 201174|Actinobacteria I Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) ispF - 2.7.7.60,4.6.1.12 ko:K01770,ko:K12506 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05633,R05637 RC00002,RC01440 ko00000,ko00001,ko00002,ko01000 - - - IspD,YgbB k59_905931_1 1125863.JAFN01000001_gene410 2.93e-97 310.0 COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,42MYQ@68525|delta/epsilon subdivisions,2WJM2@28221|Deltaproteobacteria 28221|Deltaproteobacteria L DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase dnaE2 GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 2.7.7.7 ko:K02337,ko:K14162 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_1289168_1 1465639.A0A060BR60_9CAUD 6.92e-47 167.0 4QF7H@10239|Viruses,4R06M@35237|dsDNA viruses no RNA stage,4QQTS@28883|Caudovirales,4QNXE@10744|Podoviridae 10744|Podoviridae S endonuclease activity - - - - - - - - - - - - - k59_12686_1 1229909.NSED_02495 1.08e-101 305.0 COG0520@1|root,arCOG00065@2157|Archaea,41SCV@651137|Thaumarchaeota 651137|Thaumarchaeota E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine - - 2.8.1.7,4.4.1.16 ko:K11717 ko00450,ko01100,map00450,map01100 - R03599,R11528 RC00961,RC01789,RC02313 ko00000,ko00001,ko01000 - - - Aminotran_5 k59_311799_1 240015.ACP_0677 2.11e-57 192.0 COG2204@1|root,COG2204@2|Bacteria,3Y3HH@57723|Acidobacteria,2JI5D@204432|Acidobacteriia 204432|Acidobacteriia T Sigma-54 interaction domain - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_522390_1 331869.BAL199_24519 6.96e-55 181.0 COG5446@1|root,COG5446@2|Bacteria,1RBWQ@1224|Proteobacteria,2U9NN@28211|Alphaproteobacteria 28211|Alphaproteobacteria S cobalt transporter subunit CbtA cbtA - - - - - - - - - - - CbtA k59_394181_1 153948.NAL212_1200 2.3e-51 182.0 COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,2VP0G@28216|Betaproteobacteria 28216|Betaproteobacteria P COG0471 Di- and tricarboxylate transporters - - - - - - - - - - - - CitMHS,Na_sulph_symp,TrkA_C k59_311839_1 598467.BrE312_1387 1.88e-37 144.0 COG0068@1|root,COG0068@2|Bacteria,1MVP8@1224|Proteobacteria,1RP08@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide hypF GO:0003674,GO:0003824,GO:0005488,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0010467,GO:0016740,GO:0016741,GO:0016743,GO:0019538,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046872,GO:0046914,GO:0046944,GO:0051604,GO:0071704,GO:1901564 - ko:K04656 - - - - ko00000 - - - Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF k59_1161798_1 485913.Krac_3049 2.49e-83 255.0 COG3970@1|root,COG3970@2|Bacteria,2G6JI@200795|Chloroflexi 200795|Chloroflexi S Fumarylacetoacetate (FAA) hydrolase family - - 4.2.1.141 ko:K14259 ko00040,map00040 - R09186 RC00429 ko00000,ko00001,ko01000 - - - FAA_hydrolase k59_906048_1 460265.Mnod_6639 6.57e-95 296.0 COG3666@1|root,COG3666@2|Bacteria,1QW5T@1224|Proteobacteria,2TWNW@28211|Alphaproteobacteria,1JTK7@119045|Methylobacteriaceae 28211|Alphaproteobacteria L PFAM transposase IS4 family protein tnp* - - - - - - - - - - - DDE_Tnp_1_6,DUF772 k59_394257_1 1392838.AWNM01000003_gene1746 3.1e-101 306.0 COG3508@1|root,COG3508@2|Bacteria,1MV9G@1224|Proteobacteria,2VJUH@28216|Betaproteobacteria,3T264@506|Alcaligenaceae 28216|Betaproteobacteria Q Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate - - 1.13.11.5 ko:K00451 ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120 M00044 R02519 RC00737 ko00000,ko00001,ko00002,ko01000 - - - HgmA k59_12792_1 278963.ATWD01000001_gene1073 6.42e-23 92.0 COG2963@1|root,COG2963@2|Bacteria,3Y86J@57723|Acidobacteria,2JN6K@204432|Acidobacteriia 204432|Acidobacteriia L Transposase - - - - - - - - - - - - HTH_Tnp_1 k59_12792_2 420324.KI911939_gene5367 1.08e-13 65.5 COG2801@1|root,COG2801@2|Bacteria,1P5YC@1224|Proteobacteria,2UWHS@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase and inactivated derivatives - - - - - - - - - - - - - k59_394267_1 381666.H16_B1098 6.84e-101 308.0 COG1249@1|root,COG1249@2|Bacteria,1MXQ3@1224|Proteobacteria,2VK4G@28216|Betaproteobacteria,1K23Q@119060|Burkholderiaceae 28216|Betaproteobacteria C Catalyzes the oxidation of dihydrolipoamide to lipoamide pdhD - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim k59_563885_1 987059.RBXJA2T_18733 4.54e-53 188.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2VH8J@28216|Betaproteobacteria,1KJVH@119065|unclassified Burkholderiales 28216|Betaproteobacteria P heavy metal translocating P-type ATPase - - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase k59_948675_1 977880.RALTA_A2419 5.14e-64 217.0 COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,2VJG2@28216|Betaproteobacteria,1K5NF@119060|Burkholderiaceae 28216|Betaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family fdhA - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_948675_2 1235457.C404_16500 4.01e-55 176.0 COG0437@1|root,COG0437@2|Bacteria,1MU5T@1224|Proteobacteria,2VJXP@28216|Betaproteobacteria,1KFG6@119060|Burkholderiaceae 28216|Betaproteobacteria C formate dehydrogenase fdhB - - ko:K00124,ko:K07307 ko00630,ko00680,ko00920,ko01100,ko01120,ko01200,map00630,map00680,map00920,map01100,map01120,map01200 - R00519,R09501 RC02555,RC02796 ko00000,ko00001,ko02000 5.A.3.3 - - Fer4_11,Fer4_7 k59_1079178_1 1000565.METUNv1_01937 4.77e-98 309.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,2VHXF@28216|Betaproteobacteria,2KU7U@206389|Rhodocyclales 206389|Rhodocyclales M penicillin-binding protein 1A mcrA - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - PCB_OB,Transgly,Transpeptidase k59_1204521_1 388051.AUFE01000035_gene3987 8.24e-15 70.1 COG1607@1|root,COG1607@2|Bacteria,1MZAZ@1224|Proteobacteria,2VR9M@28216|Betaproteobacteria,1K7QJ@119060|Burkholderiaceae 28216|Betaproteobacteria I Thioesterase superfamily protein yciA - - ko:K10806 ko01040,map01040 - - - ko00000,ko00001,ko01000,ko01004 - - - 4HBT k59_1204521_2 658187.LDG_7859 3.83e-53 186.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,1JCH1@118969|Legionellales 118969|Legionellales I 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain yfcX - 1.1.1.35,4.2.1.17,5.1.2.3 ko:K01782 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_1036757_1 1380394.JADL01000021_gene1881 9.04e-40 136.0 COG0346@1|root,COG0346@2|Bacteria 2|Bacteria E lactoylglutathione lyase activity - - - - - - - - - - - - Glyoxalase k59_312016_1 634498.mru_1536 1.19e-11 66.6 COG0449@1|root,arCOG00057@2157|Archaea,2XTC0@28890|Euryarchaeota,23NRN@183925|Methanobacteria 183925|Methanobacteria M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS - 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS k59_1036784_1 1288494.EBAPG3_15590 8.44e-78 252.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2VH8J@28216|Betaproteobacteria,371XZ@32003|Nitrosomonadales 28216|Betaproteobacteria P TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC copF - 3.6.3.4,3.6.3.54 ko:K01533,ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,Hydrolase,YHS k59_223945_1 1198232.CYCME_1325 7.97e-69 228.0 COG0845@1|root,COG5569@1|root,COG0845@2|Bacteria,COG5569@2|Bacteria,1MVAS@1224|Proteobacteria,1RPBZ@1236|Gammaproteobacteria,460F3@72273|Thiotrichales 72273|Thiotrichales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K07798 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4,8.A.1 - - CusF_Ec,HlyD_D23 k59_693069_1 1175306.GWL_44750 5.29e-25 104.0 COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,2VIZM@28216|Betaproteobacteria,472P4@75682|Oxalobacteraceae 28216|Betaproteobacteria D Catalyzes cross-linking of the peptidoglycan cell wall at the division septum ftsI - 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PBP_dimer,Transpeptidase k59_693069_2 1266925.JHVX01000005_gene1878 8.68e-23 90.5 COG3116@1|root,COG3116@2|Bacteria,1N6WK@1224|Proteobacteria,2VW1W@28216|Betaproteobacteria,373NV@32003|Nitrosomonadales 28216|Betaproteobacteria D Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic ftsL - - ko:K03586 - - - - ko00000,ko03036 - - - FtsL k59_610405_1 883078.HMPREF9695_04523 3.43e-80 253.0 COG1485@1|root,COG1485@2|Bacteria,1MUUW@1224|Proteobacteria,2TRG1@28211|Alphaproteobacteria,3JRCC@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S AFG1-like ATPase zapE GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0006091,GO:0006119,GO:0006123,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006996,GO:0007005,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009060,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016310,GO:0017144,GO:0019538,GO:0019637,GO:0019646,GO:0019693,GO:0022900,GO:0022904,GO:0030163,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0034641,GO:0035694,GO:0042773,GO:0042775,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0071840,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901565,GO:1901575 - ko:K06916 - - - - ko00000,ko03036 - - - AFG1_ATPase k59_12929_1 436308.Nmar_0242 5.42e-112 341.0 COG1241@1|root,arCOG00439@2157|Archaea,41SA7@651137|Thaumarchaeota 651137|Thaumarchaeota L Belongs to the MCM family - - - ko:K10726 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - MCM,MCM_N,MCM_OB k59_1334317_2 365046.Rta_12410 1.24e-39 144.0 COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2VJ3D@28216|Betaproteobacteria,4ABAW@80864|Comamonadaceae 28216|Betaproteobacteria Q D-aminoacylase domain protein - - 3.5.1.81 ko:K06015 - - R02192 RC00064,RC00328 ko00000,ko01000 - - - Amidohydro_3 k59_610502_1 460265.Mnod_0225 4.56e-13 68.6 COG0559@1|root,COG0559@2|Bacteria,1MVND@1224|Proteobacteria,2TSCF@28211|Alphaproteobacteria,1JXM2@119045|Methylobacteriaceae 28211|Alphaproteobacteria E Branched-chain amino acid transport system / permease component MA20_09930 - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_610502_2 1110502.TMO_0635 2.79e-18 86.7 COG4177@1|root,COG4177@2|Bacteria,1MY3V@1224|Proteobacteria,2U0TU@28211|Alphaproteobacteria,2JW8B@204441|Rhodospirillales 204441|Rhodospirillales E Branched-chain amino acid transport system / permease component - - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_1247333_1 666681.M301_1135 2.85e-173 496.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,2VH9X@28216|Betaproteobacteria,2KKNK@206350|Nitrosomonadales 206350|Nitrosomonadales F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB - 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH,NMO k59_1247333_2 426114.THI_2183 7.65e-99 302.0 COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,2VHNG@28216|Betaproteobacteria,1KJNP@119065|unclassified Burkholderiales 28216|Betaproteobacteria F Catalyzes the synthesis of GMP from XMP guaA - 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase k59_312147_1 1116472.MGMO_17c00180 2.81e-84 274.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,1RN6R@1236|Gammaproteobacteria,1XDY0@135618|Methylococcales 135618|Methylococcales G Belongs to the PEP-utilizing enzyme family ppdK - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_564036_1 640081.Dsui_2729 7.51e-63 200.0 COG1994@1|root,COG1994@2|Bacteria,1NSFF@1224|Proteobacteria,2VHAM@28216|Betaproteobacteria,2KVFM@206389|Rhodocyclales 206389|Rhodocyclales S Peptidase M50 - - - - - - - - - - - - Peptidase_M50 k59_564036_2 557598.LHK_02102 1.76e-201 565.0 COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,2VIEY@28216|Betaproteobacteria,2KPX8@206351|Neisseriales 206351|Neisseriales J Tryptophanyl-tRNA synthetase trpS - 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1b k59_991491_1 1123242.JH636436_gene321 5.34e-62 208.0 COG1716@1|root,COG2114@1|root,COG1716@2|Bacteria,COG2114@2|Bacteria,2IXV5@203682|Planctomycetes 203682|Planctomycetes T PFAM Adenylyl cyclase class-3 4 guanylyl cyclase - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - FHA,Guanylate_cyc k59_693200_1 491952.Mar181_3221 1.84e-41 156.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,1RM7J@1236|Gammaproteobacteria,1XHH3@135619|Oceanospirillales 135619|Oceanospirillales M penicillin-binding protein mrcA - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - PCB_OB,Transgly,Transpeptidase k59_181696_1 398580.Dshi_1053 4.53e-93 280.0 COG1176@1|root,COG1176@2|Bacteria,1R9JI@1224|Proteobacteria,2U4J9@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Binding-protein-dependent transport systems inner membrane component - - - - - - - - - - - - BPD_transp_1 k59_437487_1 1317118.ATO8_16755 2.63e-54 181.0 COG1250@1|root,COG1250@2|Bacteria,1MVVD@1224|Proteobacteria,2U0T1@28211|Alphaproteobacteria 28211|Alphaproteobacteria I 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain - - - ko:K18612 ko00750,ko01120,map00750,map01120 - R04524 RC00075 ko00000,ko00001,ko01000 - - - 3HCDH,3HCDH_N k59_1204708_1 876044.IMCC3088_2099 5.85e-79 252.0 COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,1RPX3@1236|Gammaproteobacteria,1J7AF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F 5'-nucleotidase, C-terminal domain soxB - - ko:K17224 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - 5_nucleotid_C k59_991526_1 196490.AUEZ01000038_gene5765 2.63e-72 230.0 COG2124@1|root,COG2124@2|Bacteria,1MY5H@1224|Proteobacteria,2TTRR@28211|Alphaproteobacteria,3JVM6@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria Q Cytochrome P450 MA20_16830 - - - - - - - - - - - p450 k59_394534_1 1472716.KBK24_0103260 1.6e-39 139.0 COG1917@1|root,COG1917@2|Bacteria,1RH7W@1224|Proteobacteria,2WIDZ@28216|Betaproteobacteria,1KDQ5@119060|Burkholderiaceae 28216|Betaproteobacteria S AraC-like ligand binding domain - - - - - - - - - - - - Cupin_2 k59_394534_2 1040983.AXAE01000012_gene2015 2.76e-24 101.0 COG0500@1|root,COG2226@2|Bacteria,1PPKI@1224|Proteobacteria 1224|Proteobacteria Q Methyl-transferase - - - - - - - - - - - - Methyltransf_25,Methyltransf_31,Ubie_methyltran k59_354151_1 1111732.AZOD01000001_gene1670 4.66e-08 54.3 COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,1RPKC@1236|Gammaproteobacteria,1X3S4@135614|Xanthomonadales 135614|Xanthomonadales J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) tyrS GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - S4,tRNA-synt_1b k59_1117980_1 1205680.CAKO01000038_gene1634 1.76e-39 146.0 COG2271@1|root,COG2271@2|Bacteria,1QU9E@1224|Proteobacteria,2TWHH@28211|Alphaproteobacteria,2JR0J@204441|Rhodospirillales 204441|Rhodospirillales G Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_1334488_1 313624.NSP_4370 2.43e-52 179.0 COG0056@1|root,COG0056@2|Bacteria,1FZXK@1117|Cyanobacteria,1HJTE@1161|Nostocales 2|Bacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA2 - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_1334488_2 1307759.JOMJ01000004_gene3084 3.35e-07 51.6 COG0224@1|root,COG0224@2|Bacteria,1N4GR@1224|Proteobacteria,42S5M@68525|delta/epsilon subdivisions,2WNX2@28221|Deltaproteobacteria,2M8SN@213115|Desulfovibrionales 28221|Deltaproteobacteria C ATP synthase - - - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt k59_265799_1 392499.Swit_2013 0.000178 49.7 COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2TSZZ@28211|Alphaproteobacteria,2JZXP@204457|Sphingomonadales 204457|Sphingomonadales Q COG3653 N-acyl-D-aspartate D-glutamate deacylase - - - - - - - - - - - - Amidohydro_3 k59_354170_1 365046.Rta_01670 3.09e-44 157.0 COG0697@1|root,COG0697@2|Bacteria,1MY34@1224|Proteobacteria,2VJYT@28216|Betaproteobacteria,4A9ZH@80864|Comamonadaceae 28216|Betaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA k59_354170_2 977880.RALTA_B1562 1.18e-68 215.0 COG5553@1|root,COG5553@2|Bacteria,1R5RR@1224|Proteobacteria,2VQ9W@28216|Betaproteobacteria,1K60U@119060|Burkholderiaceae 28216|Betaproteobacteria C cysteine dioxygenase type I - - - - - - - - - - - - CDO_I k59_819571_1 205922.Pfl01_0307 2.1e-17 83.2 COG3206@1|root,COG3206@2|Bacteria,1QTTW@1224|Proteobacteria,1T1H3@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Methyltransferase FkbM domain - - - - - - - - - - - - Methyltransf_21 k59_819571_3 1122165.AUHS01000018_gene1936 3.16e-32 118.0 COG2818@1|root,COG2818@2|Bacteria,1R9X5@1224|Proteobacteria,1S25K@1236|Gammaproteobacteria,1JCQG@118969|Legionellales 118969|Legionellales L Methyladenine glycosylase tag - 3.2.2.20 ko:K01246 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Adenine_glyco k59_780507_2 1123354.AUDR01000015_gene349 7.62e-44 155.0 COG1488@1|root,COG1488@2|Bacteria,1PNWY@1224|Proteobacteria,2W9DN@28216|Betaproteobacteria,1KS4Z@119069|Hydrogenophilales 119069|Hydrogenophilales H Nicotinate phosphoribosyltransferase (NAPRTase) family - - - - - - - - - - - - NAPRTase k59_1079571_2 177437.HRM2_44370 5.15e-17 76.3 COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,42NRE@68525|delta/epsilon subdivisions,2WM0E@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM IstB domain protein ATP-binding protein - - - - - - - - - - - - IstB_IS21 k59_1037145_1 1034943.BN1094_02726 1.34e-21 88.6 COG2331@1|root,COG2331@2|Bacteria,1N6Q9@1224|Proteobacteria,1SCJS@1236|Gammaproteobacteria,1JEYC@118969|Legionellales 118969|Legionellales S Putative regulatory protein - - - - - - - - - - - - Zn-ribbon_8 k59_941681_1 1095769.CAHF01000001_gene3515 1.19e-78 255.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2VH4I@28216|Betaproteobacteria,473N0@75682|Oxalobacteraceae 28216|Betaproteobacteria L DNA helicase uvrD - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_643250_1 472759.Nhal_3282 1.65e-27 110.0 COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,1RP7U@1236|Gammaproteobacteria,1WX4J@135613|Chromatiales 135613|Chromatiales J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB - 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - GatB_N,GatB_Yqey k59_643250_3 1000565.METUNv1_03176 3.63e-18 83.6 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2VIG3@28216|Betaproteobacteria,2KUD1@206389|Rhodocyclales 206389|Rhodocyclales J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_259406_1 1121423.JONT01000008_gene785 2.92e-17 85.9 COG1686@1|root,COG1686@2|Bacteria,1TQN0@1239|Firmicutes,249B3@186801|Clostridia,2606Q@186807|Peptococcaceae 186801|Clostridia M Belongs to the peptidase S11 family dacF - 3.4.16.4 ko:K07258 ko00550,ko01100,map00550,map01100 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - PBP5_C,Peptidase_S11 k59_1282579_1 1123072.AUDH01000011_gene3594 8.86e-79 256.0 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs - - - - - - - - - - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_174572_1 1123072.AUDH01000003_gene997 2.35e-71 232.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - ko:K04116 ko00362,ko01120,map00362,map01120 M00540 R05620 RC00004,RC01438 ko00000,ko00001,ko00002,ko01000 - - - AMP-binding,AMP-binding_C k59_1154914_1 331869.BAL199_06164 1.62e-195 562.0 COG0477@1|root,COG2814@2|Bacteria,1MUDA@1224|Proteobacteria,2TS0P@28211|Alphaproteobacteria 28211|Alphaproteobacteria EGP Major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_728641_1 266265.Bxe_A0208 1.14e-86 271.0 COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,2VHVY@28216|Betaproteobacteria,1K30A@119060|Burkholderiaceae 28216|Betaproteobacteria M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS - 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS k59_728641_2 504832.OCAR_5259 9.18e-30 116.0 COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,2TSR0@28211|Alphaproteobacteria,3JUVV@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria Q Flavin containing amine oxidoreductase MA20_01895 - - - - - - - - - - - Amino_oxidase k59_131511_1 748247.AZKH_0743 1.48e-56 196.0 COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2VHQQ@28216|Betaproteobacteria,2KUCM@206389|Rhodocyclales 206389|Rhodocyclales P Belongs to the monovalent cation proton antiporter 2 (cpa2) transporter (TC 2.A.37) family - - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger,TrkA_C,TrkA_N k59_1070705_1 871963.Desdi_3048 8.48e-71 222.0 COG0410@1|root,COG0410@2|Bacteria,1TPW4@1239|Firmicutes,247PN@186801|Clostridia,264ZY@186807|Peptococcaceae 186801|Clostridia E ABC transporter, ATP-binding protein - - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran k59_47191_1 426114.THI_2628 2.53e-121 368.0 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,2VJ2J@28216|Betaproteobacteria,1KIU8@119065|unclassified Burkholderiales 28216|Betaproteobacteria CP TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain L nuoL - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_C,Proton_antipo_M,Proton_antipo_N k59_1329261_1 1444711.CCJF01000005_gene419 6.28e-06 50.1 2E5FX@1|root,3307M@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_1074170_1 414684.RC1_3100 5.18e-79 242.0 COG2022@1|root,COG2022@2|Bacteria,1N0N5@1224|Proteobacteria,2TSXS@28211|Alphaproteobacteria,2JPMG@204441|Rhodospirillales 204441|Rhodospirillales H Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S thiG - 2.8.1.10 ko:K03149 ko00730,ko01100,map00730,map01100 - R10247 RC03096,RC03097,RC03461 ko00000,ko00001,ko01000 - - - ThiG,ThiS k59_1243031_1 1454004.AW11_03066 2.12e-83 262.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VI4Q@28216|Betaproteobacteria,1KQED@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria O Belongs to the peptidase S1C family degQ - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_348820_1 443152.MDG893_09611 2.25e-95 289.0 COG1703@1|root,COG1703@2|Bacteria,1MVI0@1224|Proteobacteria,1RP15@1236|Gammaproteobacteria,46AA6@72275|Alteromonadaceae 1236|Gammaproteobacteria E ArgK protein - - - - - - - - - - - - ArgK k59_390109_2 400668.Mmwyl1_0497 3.29e-31 119.0 COG3836@1|root,COG3836@2|Bacteria,1MUSG@1224|Proteobacteria,1RMWJ@1236|Gammaproteobacteria,1XN7D@135619|Oceanospirillales 135619|Oceanospirillales G Belongs to the HpcH HpaI aldolase family - - 4.1.2.52 ko:K02510 ko00350,ko01120,map00350,map01120 - R01645,R01647 RC00307,RC00572,RC00574,RC03057 ko00000,ko00001,ko01000 - - - HpcH_HpaI k59_560319_1 640081.Dsui_0500 1.32e-127 388.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2VIA1@28216|Betaproteobacteria,2KVJT@206389|Rhodocyclales 206389|Rhodocyclales KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance spoT - 2.7.6.5,3.1.7.2 ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_475742_2 1123284.KB899045_gene2362 3.18e-27 113.0 COG0679@1|root,COG0679@2|Bacteria,1UEYG@1239|Firmicutes,4HD45@91061|Bacilli,26P2M@186821|Sporolactobacillaceae 91061|Bacilli S Membrane transport protein - - - ko:K07088 - - - - ko00000 - - - Mem_trans k59_858580_1 1300350.DSW25_17200 3.28e-95 289.0 COG0683@1|root,COG0683@2|Bacteria,1MWH7@1224|Proteobacteria,2TS8K@28211|Alphaproteobacteria,3ZVJY@60136|Sulfitobacter 28211|Alphaproteobacteria E Branched-chain amino acid ABC transporter substrate-binding protein - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_902001_1 1037409.BJ6T_31870 3.1e-26 101.0 2E46N@1|root,32Z2M@2|Bacteria,1N6SH@1224|Proteobacteria,2UHDJ@28211|Alphaproteobacteria,3K55U@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_1200416_1 999541.bgla_1g10450 1.6e-26 102.0 COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,2VHR2@28216|Betaproteobacteria,1K1T9@119060|Burkholderiaceae 28216|Betaproteobacteria K Belongs to the sigma-70 factor family. ECF subfamily rpoE - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_1200416_2 391735.Veis_3245 5.06e-06 52.0 COG3073@1|root,COG3073@2|Bacteria,1N3E9@1224|Proteobacteria,2VUN0@28216|Betaproteobacteria,4AEWZ@80864|Comamonadaceae 28216|Betaproteobacteria T PFAM Anti sigma-E protein RseA family protein - - - ko:K03597 - - - - ko00000,ko03021 - - - RseA_N k59_560356_1 1538295.JY96_20670 3.04e-40 151.0 COG0457@1|root,COG0457@2|Bacteria,1Q84V@1224|Proteobacteria,2VJAQ@28216|Betaproteobacteria,1KKMD@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - DUF4440,TPR_11,TPR_16,TPR_17,TPR_19,TPR_8 k59_560356_2 1304883.KI912532_gene53 5.35e-128 379.0 COG3034@1|root,COG3034@2|Bacteria,1N2B6@1224|Proteobacteria,2VJXB@28216|Betaproteobacteria,2KVPI@206389|Rhodocyclales 206389|Rhodocyclales S L,D-transpeptidase catalytic domain - - - - - - - - - - - - YkuD k59_433252_1 1458275.AZ34_04760 1.59e-80 257.0 COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,2VGZ9@28216|Betaproteobacteria,4A9WD@80864|Comamonadaceae 28216|Betaproteobacteria J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS proS - 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_2b,tRNA_edit k59_433265_1 272123.Anacy_4247 1.09e-14 75.1 COG0045@1|root,COG1042@1|root,COG1670@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1670@2|Bacteria,1G2D3@1117|Cyanobacteria,1HIIK@1161|Nostocales 1117|Cyanobacteria CJ TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain - - - ko:K09181 - - - - ko00000 - - - ATP-grasp_5,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig k59_433265_2 1304878.AUGD01000017_gene1030 3.34e-07 52.0 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,2TW3X@28211|Alphaproteobacteria,3JW4U@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria KT Sigma-54 interaction domain - - - - - - - - - - - - HTH_8,PAS_4,Sigma54_activat k59_348956_1 710696.Intca_3418 1.81e-107 331.0 COG4412@1|root,COG4412@2|Bacteria,2GMKQ@201174|Actinobacteria,4FG03@85021|Intrasporangiaceae 201174|Actinobacteria S Immune inhibitor A peptidase M6 - - - ko:K09607 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M6 k59_646188_1 1131814.JAFO01000001_gene301 4.7e-38 143.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQPG@28211|Alphaproteobacteria,3F101@335928|Xanthobacteraceae 28211|Alphaproteobacteria T Sigma-54 interaction domain - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_219996_1 395964.KE386496_gene361 5.87e-80 254.0 COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,2TTSQ@28211|Alphaproteobacteria,3NCIH@45404|Beijerinckiaceae 28211|Alphaproteobacteria H 3-octaprenyl-4-hydroxybenzoate carboxy-lyase - - 4.1.1.98 ko:K03182 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04985,R04986 RC00391 ko00000,ko00001,ko00002,ko01000 - - - UbiD k59_1329449_1 1005048.CFU_3760 1.38e-79 245.0 COG0546@1|root,COG0546@2|Bacteria,1RCXJ@1224|Proteobacteria,2VS13@28216|Betaproteobacteria,473BT@75682|Oxalobacteraceae 28216|Betaproteobacteria S haloacid dehalogenase-like hydrolase gph - 3.1.3.105 ko:K22292 ko00520,map00520 - R11785 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 k59_1329449_2 76114.ebA914 6.53e-75 230.0 COG2227@1|root,COG2227@2|Bacteria,1MU89@1224|Proteobacteria,2VHGP@28216|Betaproteobacteria,2KVHW@206389|Rhodocyclales 206389|Rhodocyclales H O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway ubiG - 2.1.1.222,2.1.1.64 ko:K00568 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04988,R05614,R08769,R08781 RC00003,RC00392,RC01895 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_23 k59_1200503_1 983917.RGE_20770 1.09e-113 335.0 COG0798@1|root,COG0798@2|Bacteria,1MUXY@1224|Proteobacteria,2VHWA@28216|Betaproteobacteria,1KJEN@119065|unclassified Burkholderiales 28216|Betaproteobacteria P Sodium Bile acid symporter family arsB - - ko:K03325 - - - - ko00000,ko02000 2.A.59 - - SBF k59_1200503_2 795666.MW7_1439 1.32e-17 79.0 COG0346@1|root,COG0346@2|Bacteria,1RHIV@1224|Proteobacteria,2VTAR@28216|Betaproteobacteria,1K78C@119060|Burkholderiaceae 28216|Betaproteobacteria E glyoxalase bleomycin resistance protein dioxygenase - - - - - - - - - - - - Glyoxalase k59_1285489_2 1449044.JMLE01000008_gene2144 3.09e-33 119.0 COG0599@1|root,COG0599@2|Bacteria 2|Bacteria S peroxiredoxin activity yphJ - 4.1.1.44 ko:K01607 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 - R03470 RC00938 ko00000,ko00001,ko01000 - - - CMD,Cupin_2 k59_220006_1 595537.Varpa_2456 8.57e-136 402.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,2VIEB@28216|Betaproteobacteria,4A9VY@80864|Comamonadaceae 28216|Betaproteobacteria C Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg korA - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - POR,POR_N k59_475890_1 1123228.AUIH01000114_gene3699 1.58e-70 221.0 COG3703@1|root,COG3703@2|Bacteria,1QA7D@1224|Proteobacteria,1S2MT@1236|Gammaproteobacteria,1XPYX@135619|Oceanospirillales 135619|Oceanospirillales P ChaC-like protein - - - - - - - - - - - - ChaC k59_1285504_1 1177179.A11A3_06938 8.9e-11 67.4 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1XH3T@135619|Oceanospirillales 135619|Oceanospirillales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_177597_1 1000565.METUNv1_01859 1.78e-91 297.0 COG2307@1|root,COG2308@1|root,COG2307@2|Bacteria,COG2308@2|Bacteria,1MX5P@1224|Proteobacteria,2VJEU@28216|Betaproteobacteria,2KUBA@206389|Rhodocyclales 206389|Rhodocyclales S Circularly permuted ATP-grasp type 2 - - - - - - - - - - - - Alpha-E,CP_ATPgrasp_2 k59_177597_2 1149133.ppKF707_1869 7.59e-22 94.7 COG1305@1|root,COG1305@2|Bacteria,1MVMI@1224|Proteobacteria,1RXZ6@1236|Gammaproteobacteria,1YCR9@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria E Transglutaminase/protease-like homologues - - - - - - - - - - - - Bact_transglu_N,GATase_4,Transglut_core k59_1329498_1 1535422.ND16A_1814 1.63e-111 361.0 COG2132@1|root,COG2132@2|Bacteria,1PM6Q@1224|Proteobacteria,1RRZJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Parallel beta-helix repeats - - - - - - - - - - - - Cu-oxidase_3 k59_775390_1 391735.Veis_2329 1.95e-108 322.0 COG3335@1|root,COG3335@2|Bacteria,1MW7X@1224|Proteobacteria,2VMDX@28216|Betaproteobacteria 28216|Betaproteobacteria L PFAM Integrase catalytic region - - - - - - - - - - - - DDE_3,HTH_32 k59_1074408_1 1073999.BN137_3912 2.81e-08 55.5 COG2068@1|root,COG2068@2|Bacteria,1MW0X@1224|Proteobacteria,1SCSV@1236|Gammaproteobacteria 1236|Gammaproteobacteria S MobA-Related Protein ygfJ - 2.7.7.76 ko:K07141 ko00790,map00790 - R11582 - ko00000,ko00001,ko01000 - - - NTP_transf_3 k59_1074408_2 1265502.KB905930_gene1435 8.88e-35 133.0 COG1716@1|root,COG2114@1|root,COG1716@2|Bacteria,COG2114@2|Bacteria,1NAJG@1224|Proteobacteria,2VJW8@28216|Betaproteobacteria,4AATS@80864|Comamonadaceae 28216|Betaproteobacteria T Adenylyl cyclase class-3 4 guanylyl cyclase - - - - - - - - - - - - FHA,Guanylate_cyc k59_1285551_2 395493.BegalDRAFT_1907 1.83e-37 132.0 COG2050@1|root,COG2050@2|Bacteria 2|Bacteria Q thiolester hydrolase activity MA20_08885 - - ko:K17362 - - - - ko00000,ko01000,ko01004 - - - 4HBT k59_775430_1 78245.Xaut_4056 6.16e-19 85.5 COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2TR61@28211|Alphaproteobacteria,3EZ2F@335928|Xanthobacteraceae 28211|Alphaproteobacteria E PFAM ABC transporter related - - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_775430_2 1038858.AXBA01000011_gene1457 4.84e-18 81.6 COG0411@1|root,COG0411@2|Bacteria,1MUFT@1224|Proteobacteria,2TVRQ@28211|Alphaproteobacteria,3F1HX@335928|Xanthobacteraceae 28211|Alphaproteobacteria E Branched-chain amino acid ATP-binding cassette transporter - - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_1285560_1 1121479.AUBS01000001_gene3512 1.56e-85 259.0 COG0411@1|root,COG0411@2|Bacteria,1MX51@1224|Proteobacteria,2VEYC@28211|Alphaproteobacteria 28211|Alphaproteobacteria E branched-chain amino acid MA20_09940 - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_1329549_1 903814.ELI_3614 6.87e-52 176.0 COG1091@1|root,COG1091@2|Bacteria,1TP71@1239|Firmicutes,247PG@186801|Clostridia,25Y1E@186806|Eubacteriaceae 186801|Clostridia C Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose rfbD - 1.1.1.133 ko:K00067 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R02777 RC00182 ko00000,ko00001,ko00002,ko01000 - - - RmlD_sub_bind k59_775438_1 867845.KI911784_gene725 1.27e-52 188.0 COG0322@1|root,COG0322@2|Bacteria,2G651@200795|Chloroflexi,374X7@32061|Chloroflexia 32061|Chloroflexia L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC - - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH_5,UVR,UvrC_HhH_N k59_220087_1 1476583.DEIPH_ctg011orf0140 0.000149 45.8 COG4221@1|root,COG4221@2|Bacteria,1WIDQ@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_220087_2 1207055.C100_00365 1.37e-47 160.0 COG1024@1|root,COG1024@2|Bacteria,1Q51H@1224|Proteobacteria,2TUPH@28211|Alphaproteobacteria,2K2FJ@204457|Sphingomonadales 204457|Sphingomonadales I Enoyl-CoA hydratase isomerase - - 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_605608_1 1089553.Tph_c14270 2.4e-18 87.8 COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,1TP3N@1239|Firmicutes,248CS@186801|Clostridia,42EKD@68295|Thermoanaerobacterales 186801|Clostridia J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA sun - 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F,Methyltr_RsmF_N,NusB k59_605608_2 1188256.BASI01000001_gene661 0.000165 44.7 COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,2TSWX@28211|Alphaproteobacteria,3FCHH@34008|Rhodovulum 28211|Alphaproteobacteria J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus fmt GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - - Formyl_trans_C,Formyl_trans_N k59_134167_1 1205683.CAKR01000009_gene1387 4e-07 53.1 COG0583@1|root,COG0583@2|Bacteria,1N4BZ@1224|Proteobacteria,1RRCD@1236|Gammaproteobacteria,41EJY@629|Yersinia 1236|Gammaproteobacteria K Transcriptional regulatory protein - - - - - - - - - - - - HTH_1,LysR_substrate k59_134167_2 395493.BegalDRAFT_2029 3.71e-05 51.6 COG0679@1|root,COG0679@2|Bacteria,1P2SH@1224|Proteobacteria,1RQGC@1236|Gammaproteobacteria 1236|Gammaproteobacteria S auxin efflux carrier - - - ko:K07088 - - - - ko00000 - - - Mem_trans k59_987495_1 234267.Acid_1922 3.25e-62 206.0 COG2204@1|root,COG2204@2|Bacteria,3Y38J@57723|Acidobacteria 57723|Acidobacteria T Response regulator receiver - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_944871_1 1298867.AUES01000064_gene45 4.89e-66 208.0 COG1024@1|root,COG1024@2|Bacteria,1Q51H@1224|Proteobacteria,2TUPH@28211|Alphaproteobacteria,3JU70@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I Enoyl-CoA hydratase/isomerase - - 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_1243320_1 1134474.O59_001309 3.23e-46 166.0 COG3608@1|root,COG3608@2|Bacteria,1MUAA@1224|Proteobacteria,1RNQQ@1236|Gammaproteobacteria,1FFUC@10|Cellvibrio 1236|Gammaproteobacteria S Succinylglutamate desuccinylase / Aspartoacylase family - - - ko:K06987 - - - - ko00000 - - - AstE_AspA k59_1158051_1 1007105.PT7_2929 3.11e-76 234.0 COG0410@1|root,COG0410@2|Bacteria,1MVYI@1224|Proteobacteria,2VMC0@28216|Betaproteobacteria,3T3EK@506|Alcaligenaceae 28216|Betaproteobacteria E ATPases associated with a variety of cellular activities - - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran k59_560564_1 1082933.MEA186_07704 4.5e-86 262.0 COG0650@1|root,COG0650@2|Bacteria,1MXV5@1224|Proteobacteria,2U0GZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria C NADH dehydrogenase hycD - - - - - - - - - - - NADHdh k59_560564_2 1121861.KB899911_gene1293 6.95e-05 44.3 COG0651@1|root,COG0651@2|Bacteria,1MXRW@1224|Proteobacteria,2TZIX@28211|Alphaproteobacteria,2JPXG@204441|Rhodospirillales 204441|Rhodospirillales CP Proton-conducting membrane transporter - - - - - - - - - - - - Proton_antipo_M k59_390432_1 1397527.Q670_03235 9.37e-48 172.0 COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,1RQRP@1236|Gammaproteobacteria,1XKXZ@135619|Oceanospirillales 135619|Oceanospirillales Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 k59_1329672_1 96561.Dole_2838 8.16e-68 218.0 COG0673@1|root,COG0673@2|Bacteria,1MV7C@1224|Proteobacteria,42NV0@68525|delta/epsilon subdivisions,2WK1Y@28221|Deltaproteobacteria,2MHUD@213118|Desulfobacterales 28221|Deltaproteobacteria S PFAM oxidoreductase domain protein gnnA - - ko:K09949 - - - - ko00000 - - iAF987.Gmet_2352 GFO_IDH_MocA,GFO_IDH_MocA_C k59_775629_1 323848.Nmul_A2468 6.74e-68 231.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2VJIV@28216|Betaproteobacteria,372QB@32003|Nitrosomonadales 28216|Betaproteobacteria F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen nrdA GO:0000166,GO:0003674,GO:0003824,GO:0004748,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005971,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009987,GO:0016491,GO:0016725,GO:0016728,GO:0018130,GO:0019438,GO:0019637,GO:0032991,GO:0034641,GO:0034654,GO:0036094,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0055086,GO:0055114,GO:0061731,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902494,GO:1990204 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN k59_689285_1 439235.Dalk_1263 1.38e-67 213.0 COG1277@1|root,COG1277@2|Bacteria,1NZZ9@1224|Proteobacteria,42SH9@68525|delta/epsilon subdivisions,2WPWW@28221|Deltaproteobacteria,2MIHA@213118|Desulfobacterales 28221|Deltaproteobacteria N ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2,ABC2_membrane_3,ABC_transp_aux k59_177815_1 640511.BC1002_6052 6.7e-84 264.0 COG0492@1|root,COG0492@2|Bacteria,1MVX2@1224|Proteobacteria,2VM3V@28216|Betaproteobacteria,1K4AE@119060|Burkholderiaceae 28216|Betaproteobacteria C FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2,cNMP_binding k59_1032179_1 1283078.M1IPM1_9CAUD 9.9e-37 140.0 4QCM5@10239|Viruses,4QVZY@35237|dsDNA viruses no RNA stage,4QQFH@28883|Caudovirales,4QNDH@10744|Podoviridae 10744|Podoviridae S Bacteriophage head to tail connecting protein - GO:0005575,GO:0008150,GO:0016032,GO:0019012,GO:0019028,GO:0019058,GO:0019068,GO:0019072,GO:0019073,GO:0032991,GO:0044403,GO:0044419,GO:0044423,GO:0046798,GO:0051704 - - - - - - - - - - - k59_646470_1 159087.Daro_3299 1.15e-119 355.0 COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,2VJ29@28216|Betaproteobacteria,2KUJY@206389|Rhodocyclales 206389|Rhodocyclales G Phosphoglucomutase - - 5.4.2.2,5.4.2.8 ko:K15778 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_1074701_1 1121004.ATVC01000005_gene1337 1.24e-81 268.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2VIJE@28216|Betaproteobacteria,2KPRX@206351|Neisseriales 206351|Neisseriales L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_1074738_1 1157708.KB907450_gene6312 5.42e-31 119.0 COG0627@1|root,COG0627@2|Bacteria,1MY73@1224|Proteobacteria,2VS12@28216|Betaproteobacteria,4AF76@80864|Comamonadaceae 28216|Betaproteobacteria S Serine hydrolase involved in the detoxification of formaldehyde - - - - - - - - - - - - Esterase k59_387315_1 228410.NE1013 2.22e-100 298.0 COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,2VJAP@28216|Betaproteobacteria,372K7@32003|Nitrosomonadales 28216|Betaproteobacteria C cytochrome c oxidase, subunit III coxC - 1.9.3.1 ko:K02276 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.4,3.D.4.6 - - COX3 k59_1282689_1 1218075.BAYA01000006_gene2124 9.44e-60 209.0 COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,2VH7P@28216|Betaproteobacteria,1K1BN@119060|Burkholderiaceae 28216|Betaproteobacteria L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parC - - ko:K02621 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseA_C,DNA_topoisoIV k59_771813_1 1057002.KB905371_gene410 2.37e-78 248.0 COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2TRXG@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase - - - ko:K07487 - - - - ko00000 - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_984486_1 1157637.KB892124_gene795 1.81e-12 72.0 COG1975@1|root,COG1975@2|Bacteria,2GIZS@201174|Actinobacteria 201174|Actinobacteria O Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family - - - ko:K07402 - - - - ko00000 - - - XdhC_C,XdhC_CoxI k59_387350_1 1411123.JQNH01000001_gene1099 0.000203 44.3 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2TQU2@28211|Alphaproteobacteria 28211|Alphaproteobacteria I acyl-CoA dehydrogenase - - - ko:K09456 - - - - ko00000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M k59_387350_2 264732.Moth_1243 2.3e-17 85.5 COG0243@1|root,COG0243@2|Bacteria,1TPZG@1239|Firmicutes,247JV@186801|Clostridia,42IDK@68295|Thermoanaerobacterales 186801|Clostridia C Molydopterin dinucleotide binding domain - - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_1028318_1 1033802.SSPSH_000812 4.34e-44 158.0 COG3425@1|root,COG3425@2|Bacteria,1MU4K@1224|Proteobacteria,1S16F@1236|Gammaproteobacteria 1236|Gammaproteobacteria I synthase - - 2.3.3.10 ko:K01641,ko:K15311 ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130 M00088,M00095 R01978 RC00004,RC00503 ko00000,ko00001,ko00002,ko01000,ko01008 - - - HMG_CoA_synt_C,HMG_CoA_synt_N k59_941912_1 525368.HMPREF0591_4367 1.4e-27 116.0 COG3039@1|root,COG3039@2|Bacteria,2HW75@201174|Actinobacteria,237RJ@1762|Mycobacteriaceae 201174|Actinobacteria L PFAM transposase, IS4 family protein - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_899322_1 208439.AJAP_19365 2.72e-13 68.6 COG5516@1|root,COG5516@2|Bacteria,2GNZF@201174|Actinobacteria,4E4QH@85010|Pseudonocardiales 201174|Actinobacteria S CGNR zinc finger - - - - - - - - - - - - zf-CGNR k59_602046_1 1523503.JPMY01000034_gene3433 4.1e-31 118.0 COG1257@1|root,COG1257@2|Bacteria,1Q6M1@1224|Proteobacteria,1RPEP@1236|Gammaproteobacteria 1236|Gammaproteobacteria I hydroxymethylglutaryl-CoA reductase - - 1.1.1.34 ko:K00021 ko00900,ko01100,ko01110,ko01130,ko04152,ko04976,map00900,map01100,map01110,map01130,map04152,map04976 M00095 R02082 RC00004,RC00644 ko00000,ko00001,ko00002,ko01000 - - - HMG-CoA_red k59_345638_1 1535422.ND16A_1814 3.21e-79 265.0 COG2132@1|root,COG2132@2|Bacteria,1PM6Q@1224|Proteobacteria,1RRZJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Parallel beta-helix repeats - - - - - - - - - - - - Cu-oxidase_3 k59_728825_1 582744.Msip34_1544 1.25e-45 155.0 COG0777@1|root,COG0777@2|Bacteria,1MW8G@1224|Proteobacteria,2VHEQ@28216|Betaproteobacteria,2KME6@206350|Nitrosomonadales 206350|Nitrosomonadales I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA accD - 2.1.3.15,6.4.1.2 ko:K01963 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_728825_2 640081.Dsui_3191 2.69e-44 152.0 COG0159@1|root,COG0159@2|Bacteria,1MXJV@1224|Proteobacteria,2VI78@28216|Betaproteobacteria,2KV5S@206389|Rhodocyclales 206389|Rhodocyclales E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate trpA - 4.2.1.20 ko:K01695 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - Trp_syntA k59_771945_1 1163409.UUA_00840 1.48e-36 126.0 COG0239@1|root,COG0239@2|Bacteria,1MZNH@1224|Proteobacteria,1S9GR@1236|Gammaproteobacteria,1X7EW@135614|Xanthomonadales 135614|Xanthomonadales D Important for reducing fluoride concentration in the cell, thus reducing its toxicity crcB - - ko:K06199 - - - - ko00000,ko02000 1.A.43.1,1.A.43.2,1.A.43.3 - - CRCB k59_771945_2 1132855.KB913035_gene1674 4.89e-38 131.0 COG0314@1|root,COG0314@2|Bacteria,1RGUX@1224|Proteobacteria,2VRMG@28216|Betaproteobacteria,2KMVK@206350|Nitrosomonadales 206350|Nitrosomonadales H PFAM molybdopterin biosynthesis MoaE protein - - 2.8.1.12 ko:K03635 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09395 RC02507 ko00000,ko00001,ko01000 - - - MoaE k59_941944_1 998674.ATTE01000001_gene2279 4.63e-70 228.0 COG2759@1|root,COG2759@2|Bacteria,1MUR8@1224|Proteobacteria,1RME6@1236|Gammaproteobacteria,46012@72273|Thiotrichales 72273|Thiotrichales F Belongs to the formate--tetrahydrofolate ligase family fhs - 6.3.4.3 ko:K01938 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R00943 RC00026,RC00111 ko00000,ko00001,ko00002,ko01000 - - - FTHFS k59_47410_1 1121033.AUCF01000010_gene4537 8.61e-90 275.0 COG5557@1|root,COG5557@2|Bacteria,1MXP7@1224|Proteobacteria,2U3B7@28211|Alphaproteobacteria,2JW9V@204441|Rhodospirillales 204441|Rhodospirillales C Polysulphide reductase, NrfD - - - ko:K00185 - - - - ko00000 5.A.3 - - NrfD k59_387459_1 519989.ECTPHS_07092 4.2e-90 283.0 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,1RNKN@1236|Gammaproteobacteria,1WWQ6@135613|Chromatiales 135613|Chromatiales CP NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein - - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M,Proton_antipo_N k59_47437_1 768066.HELO_1028 1.27e-43 157.0 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,1RMSR@1236|Gammaproteobacteria,1XHC6@135619|Oceanospirillales 135619|Oceanospirillales M Belongs to the peptidase S41A family ctpA - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ_2,Peptidase_S41 k59_1070990_1 94624.Bpet1514 4.76e-53 184.0 COG0399@1|root,COG0399@2|Bacteria,1MUMJ@1224|Proteobacteria,2VQRJ@28216|Betaproteobacteria 28216|Betaproteobacteria M Putative transposase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_1240442_1 543728.Vapar_5387 2.09e-134 395.0 COG0654@1|root,COG0654@2|Bacteria,1MXEW@1224|Proteobacteria,2VIVN@28216|Betaproteobacteria,4AC5F@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM monooxygenase FAD-binding - - 1.14.13.218 ko:K20940 ko00405,ko01130,map00405,map01130 M00835 - - ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_3 k59_899391_1 335283.Neut_0279 1.83e-39 143.0 COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,2VH54@28216|Betaproteobacteria,372BE@32003|Nitrosomonadales 28216|Betaproteobacteria M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain glmU - 2.3.1.157,2.7.7.23 ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,Hexapep_2,NTP_transf_3 k59_899391_2 626418.bglu_1g32790 8.76e-198 567.0 COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,2VHVY@28216|Betaproteobacteria,1K30A@119060|Burkholderiaceae 28216|Betaproteobacteria M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS - 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS k59_47468_1 443598.AUFA01000041_gene6109 6.54e-65 210.0 COG1960@1|root,COG1960@2|Bacteria,1MX17@1224|Proteobacteria,2TTRE@28211|Alphaproteobacteria,3JYE6@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_47468_2 335543.Sfum_3501 2.4e-43 155.0 COG2271@1|root,COG2271@2|Bacteria,1QXP5@1224|Proteobacteria,43C51@68525|delta/epsilon subdivisions,2X7FD@28221|Deltaproteobacteria,2MR8I@213462|Syntrophobacterales 28221|Deltaproteobacteria G PFAM Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_728895_1 491916.RHECIAT_PC0000179 1.85e-43 149.0 COG2370@1|root,COG2370@2|Bacteria,1N08F@1224|Proteobacteria,2UA0Y@28211|Alphaproteobacteria,4B7VB@82115|Rhizobiaceae 28211|Alphaproteobacteria O HupE / UreJ protein hupE GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K03192 - - - - ko00000 - - - HupE_UreJ k59_1071013_1 85643.Tmz1t_2429 2.09e-100 301.0 COG0416@1|root,COG0416@2|Bacteria,1MVM3@1224|Proteobacteria,2VI25@28216|Betaproteobacteria,2KUA0@206389|Rhodocyclales 206389|Rhodocyclales I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA plsX - 2.3.1.15 ko:K03621 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FA_synthesis k59_174858_1 1163617.SCD_n01442 3.56e-26 107.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2VHRB@28216|Betaproteobacteria 28216|Betaproteobacteria V Abc transporter - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran,DUF4162 k59_174858_2 1123368.AUIS01000024_gene949 4.1e-06 48.5 COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,1RPB4@1236|Gammaproteobacteria,2NBU9@225057|Acidithiobacillales 225057|Acidithiobacillales V ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 k59_1155211_2 365044.Pnap_1375 2.09e-51 171.0 COG2834@1|root,COG2834@2|Bacteria,1RHYN@1224|Proteobacteria,2VSXY@28216|Betaproteobacteria,4AEIN@80864|Comamonadaceae 28216|Betaproteobacteria M Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - - - - - - - - - - LolA k59_131781_1 1150599.MPHLEI_02793 2.43e-10 66.2 COG3209@1|root,COG3209@2|Bacteria,2I60K@201174|Actinobacteria,2375A@1762|Mycobacteriaceae 201174|Actinobacteria M Protein conserved in bacteria - - - - - - - - - - - - Cadherin_3,RCC1_2 k59_1071118_1 717605.Theco_2967 6.46e-05 44.7 COG2146@1|root,COG2146@2|Bacteria,1VBNU@1239|Firmicutes,4HKDI@91061|Bacilli,26Y4E@186822|Paenibacillaceae 91061|Bacilli P Nitrite reductase nasE - 1.7.1.15 ko:K00363 ko00910,ko01120,map00910,map01120 M00530 R00787 RC00176 ko00000,ko00001,ko00002,ko01000 - - iYO844.BSU03290 Rieske,Rieske_2 k59_1071118_2 768671.ThimaDRAFT_4789 1.7e-102 309.0 COG0547@1|root,COG0547@2|Bacteria,1QDR6@1224|Proteobacteria,1T9UH@1236|Gammaproteobacteria,1WW56@135613|Chromatiales 135613|Chromatiales E PFAM Glycosyl transferase, family - - - - - - - - - - - - Glycos_trans_3N,Glycos_transf_3 k59_5602_2 420662.Mpe_B0541 5.62e-58 196.0 COG1884@1|root,COG1884@2|Bacteria,1MUXX@1224|Proteobacteria,2VIT2@28216|Betaproteobacteria,1KK96@119065|unclassified Burkholderiales 28216|Betaproteobacteria I Methylmalonyl-CoA mutase icmF - 5.4.99.2,5.4.99.63,5.4.99.64 ko:K01847,ko:K01848,ko:K14447,ko:K20906 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00375,M00376,M00741 R00833,R09292 RC00395,RC02835 ko00000,ko00001,ko00002,ko01000 - - - ArgK,B12-binding,MM_CoA_mutase k59_131838_1 1246.JMEA01000004_gene1539 1.6e-10 63.2 COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,4H9S5@91061|Bacilli,4AX5W@81850|Leuconostocaceae 91061|Bacilli P Cation transport ATPase pacL - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase k59_131838_2 338969.Rfer_0088 1.38e-29 117.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,2VJK5@28216|Betaproteobacteria,4AD52@80864|Comamonadaceae 28216|Betaproteobacteria G Pyruvate phosphate dikinase, PEP/pyruvate binding domain ppdK - 2.7.9.1,2.7.9.2 ko:K01006,ko:K01007 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173,M00374 R00199,R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_47663_1 716928.AJQT01000080_gene2244 1.02e-59 208.0 COG0365@1|root,COG0654@1|root,COG0365@2|Bacteria,COG0654@2|Bacteria,1QV6A@1224|Proteobacteria,2TWBF@28211|Alphaproteobacteria,4BNVK@82115|Rhizobiaceae 28211|Alphaproteobacteria CHI AMP-binding enzyme C-terminal domain - - - - - - - - - - - - AMP-binding,AMP-binding_C,FAD_binding_3,NAD_binding_8 k59_1112184_1 1122619.KB892322_gene8 1.29e-51 181.0 COG4372@1|root,COG4372@2|Bacteria,1MUCX@1224|Proteobacteria,2WGN9@28216|Betaproteobacteria,3T3JA@506|Alcaligenaceae 28216|Betaproteobacteria S Transposase IS66 family - - - - - - - - - - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66 k59_5696_1 215803.DB30_4002 1.37e-44 152.0 COG1309@1|root,COG1309@2|Bacteria,1R6RX@1224|Proteobacteria,42T50@68525|delta/epsilon subdivisions,2WPVV@28221|Deltaproteobacteria,2YUY1@29|Myxococcales 28221|Deltaproteobacteria K Bacterial regulatory proteins, tetR family - - - ko:K16137 - - - - ko00000,ko03000 - - - TetR_C_13,TetR_N k59_1112220_1 935261.JAGL01000009_gene1165 9.11e-53 184.0 COG0209@1|root,COG0209@2|Bacteria,1PM78@1224|Proteobacteria,2UZUM@28211|Alphaproteobacteria,43QGW@69277|Phyllobacteriaceae 28211|Alphaproteobacteria F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides - - - - - - - - - - - - - k59_131912_1 766499.C357_04497 2.21e-64 212.0 COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,2TUMJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria E aminotransferase class V - - - - - - - - - - - - Aminotran_5 k59_1155416_1 1219035.NT2_04_01460 0.00067 47.8 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,2TSE2@28211|Alphaproteobacteria,2K21U@204457|Sphingomonadales 204457|Sphingomonadales E Glutamate synthase gltD - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - Fer4_20,Pyr_redox_2 k59_1326410_1 675812.VHA_002682 7.14e-07 56.2 COG2885@1|root,COG3637@1|root,COG2885@2|Bacteria,COG3637@2|Bacteria,1N6EM@1224|Proteobacteria,1SBXG@1236|Gammaproteobacteria,1XU00@135623|Vibrionales 135623|Vibrionales M Belongs to the ompA family - - - ko:K03286 - - - - ko00000,ko02000 1.B.6 - - OMP_b-brl,OmpA,OmpA_membrane k59_1112244_1 1123504.JQKD01000015_gene956 1.79e-86 275.0 COG0296@1|root,COG0296@2|Bacteria,1MVM7@1224|Proteobacteria,2VJDX@28216|Betaproteobacteria,4AA76@80864|Comamonadaceae 28216|Betaproteobacteria G SMART alpha amylase catalytic sub domain treZ - 3.2.1.141 ko:K01236 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11256 RC00049 ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48,DUF3459 k59_1028775_1 420324.KI912084_gene7398 2.54e-48 172.0 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,1JSYN@119045|Methylobacteriaceae 28211|Alphaproteobacteria T PFAM Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - Guanylate_cyc,TPR_8 k59_856523_1 1500301.JQMF01000003_gene4335 7.01e-30 121.0 COG0745@1|root,COG2199@1|root,COG0745@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2TQQM@28211|Alphaproteobacteria,4BAYB@82115|Rhizobiaceae 28211|Alphaproteobacteria T Response regulator containing a CheY-like receiver domain and a GGDEF domain pleD GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0042802,GO:0044424,GO:0044464 2.7.7.65 ko:K02488 ko02020,ko04112,map02020,map04112 M00511 R08057 - ko00000,ko00001,ko00002,ko01000,ko02022 - - - GGDEF,Response_reg k59_516097_1 1089552.KI911559_gene1732 9.57e-105 317.0 COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria,2JQ0Z@204441|Rhodospirillales 204441|Rhodospirillales Q COG4664 TRAP-type mannitol chloroaromatic compound transport system, large permease component - - - - - - - - - - - - DctM k59_813888_2 757424.Hsero_0927 3e-58 193.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VHT0@28216|Betaproteobacteria,473VB@75682|Oxalobacteraceae 28216|Betaproteobacteria I Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_772361_1 997346.HMPREF9374_1321 1.77e-25 109.0 COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,4HAHB@91061|Bacilli,27CMI@186824|Thermoactinomycetaceae 91061|Bacilli IQ AMP-binding enzyme C-terminal domain yngI - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_473458_1 51337.XP_004661373.1 7.52e-70 231.0 COG0028@1|root,KOG1185@2759|Eukaryota,38EFU@33154|Opisthokonta,3BGF6@33208|Metazoa,3CUC0@33213|Bilateria,4815T@7711|Chordata,494NR@7742|Vertebrata,3J1W3@40674|Mammalia,35GX4@314146|Euarchontoglires,4PSSW@9989|Rodentia 33208|Metazoa EH fatty acid alpha-oxidation HACL1 GO:0001561,GO:0003674,GO:0003824,GO:0005102,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0005782,GO:0005829,GO:0006082,GO:0006605,GO:0006625,GO:0006629,GO:0006631,GO:0006810,GO:0006886,GO:0006996,GO:0007031,GO:0008104,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0015031,GO:0015833,GO:0016042,GO:0016043,GO:0016054,GO:0016829,GO:0016830,GO:0019395,GO:0019752,GO:0019842,GO:0022607,GO:0030258,GO:0030976,GO:0031907,GO:0031974,GO:0032787,GO:0033036,GO:0033365,GO:0034440,GO:0034613,GO:0036094,GO:0042579,GO:0042802,GO:0042886,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043574,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044464,GO:0045184,GO:0046395,GO:0046907,GO:0048037,GO:0050662,GO:0051179,GO:0051234,GO:0051259,GO:0051641,GO:0051649,GO:0055114,GO:0065003,GO:0070013,GO:0070727,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0072329,GO:0072594,GO:0072662,GO:0072663,GO:0097159,GO:1901363,GO:1901575,GO:1901681 - ko:K12261 ko04146,map04146 - - - ko00000,ko00001,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_772400_1 1089552.KI911559_gene322 6.49e-63 199.0 COG0118@1|root,COG0118@2|Bacteria,1MU4X@1224|Proteobacteria,2TTT4@28211|Alphaproteobacteria,2JPEU@204441|Rhodospirillales 204441|Rhodospirillales E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR hisH - - ko:K02501 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - GATase k59_1198133_1 1461693.ATO10_01800 8.71e-59 199.0 COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,2TQYG@28211|Alphaproteobacteria 28211|Alphaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072,ko:K12257 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_942332_1 1236494.BAJN01000002_gene371 7.85e-07 53.5 2DMPS@1|root,32SXU@2|Bacteria,4NTIT@976|Bacteroidetes 976|Bacteroidetes J PFAM S23 ribosomal protein - - - - - - - - - - - - 23S_rRNA_IVP k59_1071427_1 637389.Acaty_c0690 9.36e-21 86.7 2EGD6@1|root,33A4Z@2|Bacteria,1N733@1224|Proteobacteria,1SEIJ@1236|Gammaproteobacteria,2NDDB@225057|Acidithiobacillales 225057|Acidithiobacillales S Protein of unknown function (DUF2892) - - - - - - - - - - - - DUF2892 k59_1155549_1 443598.AUFA01000039_gene5980 5.31e-28 112.0 COG0697@1|root,COG0697@2|Bacteria,1MYHQ@1224|Proteobacteria,2U4JI@28211|Alphaproteobacteria,3K0JH@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA k59_643929_1 557598.LHK_01482 1.26e-75 235.0 COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,2VIVV@28216|Betaproteobacteria,2KPDC@206351|Neisseriales 206351|Neisseriales C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family trxB - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_1283224_1 748247.AZKH_0183 5.73e-43 155.0 COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,2VMNB@28216|Betaproteobacteria 28216|Betaproteobacteria C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B coxN - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 k59_260025_1 713586.KB900536_gene1506 1.41e-46 168.0 COG0651@1|root,COG0651@2|Bacteria,1MXRW@1224|Proteobacteria,1RM9Q@1236|Gammaproteobacteria,1WW1W@135613|Chromatiales 135613|Chromatiales CP Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit - - - ko:K05568 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - Proton_antipo_M k59_1155580_1 62928.azo1569 9.74e-65 206.0 COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,2VIHE@28216|Betaproteobacteria,2KV9V@206389|Rhodocyclales 206389|Rhodocyclales I Enoyl- acyl-carrier-protein reductase NADH fabI - 1.3.1.10,1.3.1.9 ko:K00208 ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212 M00083,M00572 R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671 RC00052,RC00076,RC00120 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_985065_1 1159870.KB907784_gene1384 9.8e-75 251.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,2VHUY@28216|Betaproteobacteria,3T27V@506|Alcaligenaceae 28216|Betaproteobacteria E glutamate synthase gltB - 1.4.1.13,1.4.1.14,1.4.7.1 ko:K00265,ko:K00284 ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 - R00021,R00093,R00114,R00248,R10086 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_47958_1 754477.Q7C_490 1.08e-50 177.0 COG0399@1|root,COG0399@2|Bacteria,1MUMJ@1224|Proteobacteria,1RSDY@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Transposase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_813995_1 1121937.AUHJ01000004_gene1013 6.33e-64 208.0 COG2801@1|root,COG2801@2|Bacteria,1MXKK@1224|Proteobacteria,1T7KM@1236|Gammaproteobacteria,46C37@72275|Alteromonadaceae 1236|Gammaproteobacteria L PFAM Integrase - - - - - - - - - - - - - k59_1112407_1 1121459.AQXE01000001_gene2749 2.81e-32 128.0 28IA2@1|root,2Z8CQ@2|Bacteria,1PQM2@1224|Proteobacteria,42Y9U@68525|delta/epsilon subdivisions,2WTUC@28221|Deltaproteobacteria,2MARZ@213115|Desulfovibrionales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_1326660_1 583345.Mmol_0644 2.23e-29 116.0 COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,2VH1F@28216|Betaproteobacteria,2KMQE@206350|Nitrosomonadales 206350|Nitrosomonadales T HD domain - - - ko:K07814 - - - - ko00000,ko02022 - - - HD,Response_reg k59_6029_2 1208918.CDEE_0274 9.5e-10 63.2 COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,2VHC2@28216|Betaproteobacteria,1KPT3@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III hemE - 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - - URO-D k59_6038_1 1121033.AUCF01000026_gene2996 1.54e-10 61.6 COG2197@1|root,COG2197@2|Bacteria,1R2TM@1224|Proteobacteria,2TU4S@28211|Alphaproteobacteria,2JUFZ@204441|Rhodospirillales 204441|Rhodospirillales T helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg k59_6038_2 287.DR97_1887 1.63e-45 160.0 COG0330@1|root,COG0330@2|Bacteria,1MWMD@1224|Proteobacteria,1RNGH@1236|Gammaproteobacteria,1YFSM@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria O prohibitin homologues - - - - - - - - - - - - Band_7 k59_856696_2 1089552.KI911559_gene3442 6.5e-73 236.0 COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,2TU11@28211|Alphaproteobacteria,2JQAF@204441|Rhodospirillales 204441|Rhodospirillales C Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family glpD - 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - DAO,DAO_C k59_89580_1 316056.RPC_2070 7.36e-172 490.0 COG5433@1|root,COG5433@2|Bacteria,1MXB5@1224|Proteobacteria,2U26E@28211|Alphaproteobacteria,3K2QG@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L PFAM transposase, IS4 family protein - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_assoc k59_132126_1 1100720.ALKN01000026_gene1675 3.83e-78 254.0 28JZQ@1|root,2Z9PN@2|Bacteria,1N2WN@1224|Proteobacteria,2VI2S@28216|Betaproteobacteria,4AD2Q@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_263449_2 1342302.JASC01000014_gene1416 1.5e-33 130.0 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria,3ZUSX@60136|Sulfitobacter 28211|Alphaproteobacteria C carbon monoxide dehydrogenase coxL - 1.2.5.3 ko:K03520 - - R11168 RC02800 ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_520084_2 1207063.P24_08184 2.39e-58 191.0 2C7F6@1|root,2Z8AK@2|Bacteria,1PEE5@1224|Proteobacteria,2TTH2@28211|Alphaproteobacteria,2JR3R@204441|Rhodospirillales 204441|Rhodospirillales - - - - - - - - - - - - - - - k59_556439_1 987059.RBXJA2T_00819 2.51e-49 162.0 COG0454@1|root,COG0456@2|Bacteria,1NPCX@1224|Proteobacteria 1224|Proteobacteria K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_7 k59_1323981_1 675635.Psed_4311 3.21e-58 193.0 COG1893@1|root,COG1893@2|Bacteria,2I3AM@201174|Actinobacteria,4E3ZP@85010|Pseudonocardiales 201174|Actinobacteria H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid - - 1.1.1.169 ko:K00077 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R02472 RC00726 ko00000,ko00001,ko00002,ko01000 - - - ApbA,ApbA_C k59_173014_1 1437448.AZRT01000125_gene1186 1.34e-22 95.9 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_173014_2 243090.RB3257 7.66e-17 73.2 COG1598@1|root,COG1598@2|Bacteria,2J44T@203682|Planctomycetes 203682|Planctomycetes S PFAM Uncharacterised protein family UPF0150 - - - - - - - - - - - - - k59_1068731_1 296591.Bpro_2799 3.28e-81 246.0 COG0664@1|root,COG0664@2|Bacteria,1R64V@1224|Proteobacteria,2VJXN@28216|Betaproteobacteria,4ACEI@80864|Comamonadaceae 28216|Betaproteobacteria T Cyclic nucleotide-monophosphate binding domain - - - - - - - - - - - - cNMP_binding k59_812066_1 1469245.JFBG01000027_gene1468 1.64e-39 141.0 COG1173@1|root,COG1173@2|Bacteria,1MUG0@1224|Proteobacteria,1RN08@1236|Gammaproteobacteria,1X2PA@135613|Chromatiales 135613|Chromatiales EP Binding-protein-dependent transport system inner membrane component - - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_812066_2 1380394.JADL01000016_gene414 1.31e-83 257.0 COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TRS8@28211|Alphaproteobacteria 28211|Alphaproteobacteria EP Binding-protein-dependent transport system inner membrane component nikB - - ko:K02033,ko:K15585 ko02010,ko02024,map02010,map02024 M00239,M00440 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_769888_2 1411123.JQNH01000001_gene2070 2.01e-124 359.0 COG3485@1|root,COG3485@2|Bacteria,1MUYX@1224|Proteobacteria,2TU2C@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q protocatechuate 3,4-dioxygenase, beta subunit' pcaH - 1.13.11.3 ko:K00449 ko00362,ko00624,ko01100,ko01120,ko01220,map00362,map00624,map01100,map01120,map01220 - R01631,R03549 RC00388,RC00953 br01602,ko00000,ko00001,ko01000 - - - Dioxygenase_C,PCDO_beta_N k59_769888_3 257313.BP1238 1.25e-81 248.0 COG0625@1|root,COG0625@2|Bacteria,1RA4Y@1224|Proteobacteria,2VKEU@28216|Betaproteobacteria,3T1GJ@506|Alcaligenaceae 28216|Betaproteobacteria O Maleylacetoacetate isomerase maiA - 5.2.1.2,5.2.1.4 ko:K01800,ko:K01801 ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120 M00044 R03181,R03868 RC00867 ko00000,ko00001,ko00002,ko01000 - - - GST_C,GST_C_2,GST_C_3,GST_N,GST_N_3 k59_3181_1 1150469.RSPPHO_00278 2.67e-47 162.0 COG0500@1|root,COG2226@2|Bacteria,1RB4F@1224|Proteobacteria,2U613@28211|Alphaproteobacteria,2JSGA@204441|Rhodospirillales 204441|Rhodospirillales Q methyltransferase - - - - - - - - - - - - Methyltransf_25 k59_1153399_1 765911.Thivi_0796 5.02e-50 181.0 COG4262@1|root,COG4262@2|Bacteria,1RFZS@1224|Proteobacteria,1S1NP@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - - - - - - - - - - - k59_727144_1 1380394.JADL01000011_gene3985 4.32e-104 313.0 COG3552@1|root,COG3552@2|Bacteria,1MUHH@1224|Proteobacteria,2TSXR@28211|Alphaproteobacteria,2JR83@204441|Rhodospirillales 204441|Rhodospirillales S VWA domain containing CoxE-like protein - - - ko:K07161 - - - - ko00000 - - - VWA_CoxE k59_641832_1 1121374.KB891576_gene247 3.6e-47 159.0 COG3764@1|root,COG3764@2|Bacteria,1P806@1224|Proteobacteria,1S9RI@1236|Gammaproteobacteria 1236|Gammaproteobacteria M PFAM peptidase C60, sortase A and B srtA - 3.4.22.70 ko:K07284 - - - - ko00000,ko01000,ko01002,ko01011 - - - Sortase k59_854790_1 926550.CLDAP_34830 2.29e-52 187.0 COG0525@1|root,COG0525@2|Bacteria,2G5VS@200795|Chloroflexi 200795|Chloroflexi J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS - 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_385880_1 1408254.T458_05965 9.79e-32 121.0 COG1484@1|root,COG1484@2|Bacteria,1TPPI@1239|Firmicutes,4HAKP@91061|Bacilli,275FX@186822|Paenibacillaceae 91061|Bacilli L Bacterial dnaA protein - - - - - - - - - - - - IstB_IS21 k59_599989_1 983917.RGE_33960 6.95e-79 259.0 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,2VH5Z@28216|Betaproteobacteria,1KJN2@119065|unclassified Burkholderiales 28216|Betaproteobacteria J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS - 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_343719_1 497965.Cyan7822_1129 9.22e-47 167.0 COG3385@1|root,COG3385@2|Bacteria,1GK9H@1117|Cyanobacteria,3KKFV@43988|Cyanothece 1117|Cyanobacteria L transposase activity - - - - - - - - - - - - - k59_428853_1 1499967.BAYZ01000027_gene1790 5.34e-23 100.0 COG2804@1|root,COG2804@2|Bacteria,2NNNI@2323|unclassified Bacteria 2|Bacteria NU Type II secretion system (T2SS), protein E, N-terminal domain pilB - - ko:K02454,ko:K02504,ko:K02652 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSE,T2SSE_N k59_87700_1 640081.Dsui_2858 9.47e-63 205.0 COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,2VH7C@28216|Betaproteobacteria,2KVIV@206389|Rhodocyclales 206389|Rhodocyclales M lipoprotein releasing system, transmembrane protein, LolC E family - - - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD k59_87700_2 582744.Msip34_0634 3.08e-96 287.0 COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,2VHAQ@28216|Betaproteobacteria,2KMB3@206350|Nitrosomonadales 206350|Nitrosomonadales V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner lolD - - ko:K09810 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.125 - - ABC_tran k59_770028_1 463191.SSEG_02830 9.8e-18 89.7 COG0644@1|root,COG0644@2|Bacteria,2GJDF@201174|Actinobacteria 201174|Actinobacteria C Tryptophan halogenase - - - ko:K21256 ko01059,ko01130,map01059,map01130 M00833,M00834 R11414 RC01363 ko00000,ko00001,ko00002 - - - Trp_halogenase k59_770028_2 323848.Nmul_A0073 1.27e-16 75.5 COG3448@1|root,COG3448@2|Bacteria,1PW0P@1224|Proteobacteria,2WBMR@28216|Betaproteobacteria,373ER@32003|Nitrosomonadales 28216|Betaproteobacteria T HPP family - - - - - - - - - - - - HPP k59_727223_1 438753.AZC_3597 2.61e-120 368.0 COG0749@1|root,COG0749@2|Bacteria,1P27P@1224|Proteobacteria,2TVEI@28211|Alphaproteobacteria 28211|Alphaproteobacteria L DNA polymerase family A - - - - - - - - - - - - DNA_pol_A k59_940339_1 443598.AUFA01000002_gene2422 7.6e-26 104.0 COG0683@1|root,COG0683@2|Bacteria,1N11P@1224|Proteobacteria,2TRQ4@28211|Alphaproteobacteria,3JVI6@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Periplasmic binding protein - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_940339_2 443598.AUFA01000002_gene2421 9.13e-108 318.0 COG0559@1|root,COG0559@2|Bacteria,1MY1E@1224|Proteobacteria,2U0TW@28211|Alphaproteobacteria,3JUC4@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Branched-chain amino acid transport system / permease component - - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_1281236_1 190650.CC_2397 6.32e-121 365.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TRI3@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Belongs to the aldehyde dehydrogenase family - - 1.2.1.28 ko:K00141 ko00622,ko00623,ko00627,ko01100,ko01120,ko01220,map00622,map00623,map00627,map01100,map01120,map01220 M00537,M00538 R01293,R01419,R05289,R05663,R05664,R07667 RC00075 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_215718_1 1267005.KB911259_gene3979 6.33e-83 257.0 COG0665@1|root,COG0665@2|Bacteria,1MVM6@1224|Proteobacteria,2TRM7@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Sarcosine oxidase, beta subunit soxB2 - 1.5.3.1,1.5.99.5 ko:K00303,ko:K22084 ko00260,ko00680,ko01100,ko01120,map00260,map00680,map01100,map01120 - R00609,R00610 RC00060,RC00190,RC00557 ko00000,ko00001,ko01000 - - - DAO k59_130345_1 886293.Sinac_7540 4.24e-63 210.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,2IX43@203682|Planctomycetes 203682|Planctomycetes F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH k59_428953_1 224911.27354655 3.59e-24 102.0 COG1042@1|root,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2TR24@28211|Alphaproteobacteria,3JRT1@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C CoA binding domain - - - ko:K09181 - - - - ko00000 - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig k59_684703_1 436308.Nmar_1117 1.67e-106 313.0 COG2759@1|root,arCOG04538@2157|Archaea,41S6B@651137|Thaumarchaeota 651137|Thaumarchaeota F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate folD - 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 - - - THF_DHG_CYH,THF_DHG_CYH_C k59_87799_1 1385935.N836_02685 4.04e-65 211.0 COG3367@1|root,COG3367@2|Bacteria,1GA7A@1117|Cyanobacteria 1117|Cyanobacteria S COGs COG3367 conserved - - - - - - - - - - - - - k59_258296_2 1304883.KI912532_gene511 1.54e-107 323.0 COG0116@1|root,COG0116@2|Bacteria,1MUQM@1224|Proteobacteria,2VHMY@28216|Betaproteobacteria,2KV05@206389|Rhodocyclales 206389|Rhodocyclales L Belongs to the methyltransferase superfamily - - - ko:K07444 - - - - ko00000,ko01000 - - - THUMP,UPF0020 k59_514232_1 1192124.LIG30_2479 7.47e-27 105.0 COG0313@1|root,COG0313@2|Bacteria,1RARW@1224|Proteobacteria,2VQ34@28216|Betaproteobacteria,1K2ET@119060|Burkholderiaceae 28216|Betaproteobacteria H PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase rsmI_2 - 2.1.1.198 ko:K07056 - - - - ko00000,ko01000,ko03009 - - - TP_methylase k59_514232_2 1485544.JQKP01000001_gene1225 1.54e-42 149.0 COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,2VH94@28216|Betaproteobacteria,44V82@713636|Nitrosomonadales 28216|Betaproteobacteria OU Peptidase family S49 sppA - - ko:K04773 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49 k59_684727_1 604354.TSIB_1371 5.28e-38 140.0 COG1131@1|root,arCOG00194@2157|Archaea,2XTJV@28890|Euryarchaeota,243U5@183968|Thermococci 183968|Thermococci V Domain of unknown function (DUF4162) - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran,DUF4162 k59_770195_1 335659.S23_05530 1.28e-33 134.0 COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,3JTQ7@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - AAA_16,DZR,Guanylate_cyc,SAM_1 k59_386069_1 1178825.ALIH01000002_gene833 2.62e-07 59.7 COG2885@1|root,COG2885@2|Bacteria,4NE6G@976|Bacteroidetes,1HXNY@117743|Flavobacteriia 976|Bacteroidetes M Belongs to the ompA family - - - - - - - - - - - - CarboxypepD_reg,OmpA,PD40 k59_215838_2 1116375.VEJY3_00195 4.5e-09 57.0 COG3245@1|root,COG3245@2|Bacteria,1MZBZ@1224|Proteobacteria,1S9Z9@1236|Gammaproteobacteria,1XX0W@135623|Vibrionales 135623|Vibrionales C cytochrome c5 cycB - - - - - - - - - - - Cytochrome_CBB3 k59_812330_1 911045.PSE_3669 1.04e-05 47.0 COG1960@1|root,COG1960@2|Bacteria,1MVJC@1224|Proteobacteria,2TQRA@28211|Alphaproteobacteria 28211|Alphaproteobacteria I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_812330_2 570967.JMLV01000012_gene3228 4.88e-52 172.0 COG0066@1|root,COG0066@2|Bacteria,1MVXB@1224|Proteobacteria,2TRRS@28211|Alphaproteobacteria,2JPTP@204441|Rhodospirillales 204441|Rhodospirillales E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuD - 4.2.1.33,4.2.1.35 ko:K01704 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R10170 RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase_C k59_812330_3 1205680.CAKO01000038_gene2055 1.68e-130 385.0 COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,2TVD2@28211|Alphaproteobacteria,2JV9U@204441|Rhodospirillales 204441|Rhodospirillales E Aconitase family (aconitate hydratase) - - - - - - - - - - - - Aconitase k59_1238936_1 296591.Bpro_0610 1.92e-88 287.0 COG3188@1|root,COG3188@2|Bacteria,1MWV6@1224|Proteobacteria,2VIR3@28216|Betaproteobacteria,4AD84@80864|Comamonadaceae 28216|Betaproteobacteria NU Outer membrane usher protein - - - ko:K07347 ko05133,map05133 - - - ko00000,ko00001,ko02000,ko02035,ko02044 1.B.11.3 - - PapC_C,Usher k59_855012_1 551789.ATVJ01000003_gene213 3.42e-06 48.5 COG1960@1|root,COG1960@2|Bacteria,1MUBH@1224|Proteobacteria,2TSKH@28211|Alphaproteobacteria,43WQD@69657|Hyphomonadaceae 28211|Alphaproteobacteria I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_770257_2 204773.HEAR0405 2.76e-23 97.1 COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,2VHEP@28216|Betaproteobacteria,472FK@75682|Oxalobacteraceae 28216|Betaproteobacteria F Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) miaA - 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 - R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 - - - IPPT k59_1026601_1 1123392.AQWL01000009_gene1080 1.21e-43 144.0 2BK43@1|root,32EHP@2|Bacteria,1RDAC@1224|Proteobacteria,2W3NZ@28216|Betaproteobacteria,1KT43@119069|Hydrogenophilales 119069|Hydrogenophilales - - - - - - - - - - - - - - - k59_1026601_2 1158756.AQXQ01000012_gene1996 7.22e-66 205.0 COG1047@1|root,COG1047@2|Bacteria,1REQ1@1224|Proteobacteria,1S2MS@1236|Gammaproteobacteria,1WY6J@135613|Chromatiales 135613|Chromatiales O Peptidyl-prolyl cis-trans - - 5.2.1.8 ko:K03775 - - - - ko00000,ko01000,ko03110 - - - - k59_173351_1 1189620.AJXL01000048_gene1280 4.73e-27 114.0 COG2091@1|root,COG2091@2|Bacteria,4NFQ6@976|Bacteroidetes,1HWM8@117743|Flavobacteriia,2NTD0@237|Flavobacterium 976|Bacteroidetes H Carbohydrate family 9 binding domain-like - - - - - - - - - - - - CBM9_1 k59_1238980_1 398580.Dshi_2295 8.66e-29 117.0 COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2TTYC@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q COG1228 Imidazolonepropionase and related amidohydrolases - - - - - - - - - - - - Amidohydro_1 k59_1026645_1 1121015.N789_10585 2.92e-20 89.0 COG0350@1|root,COG2169@1|root,COG0350@2|Bacteria,COG2169@2|Bacteria,1N2YQ@1224|Proteobacteria,1RPR3@1236|Gammaproteobacteria,1X5E0@135614|Xanthomonadales 135614|Xanthomonadales FL Methyltransferase - - 2.1.1.63 ko:K10778 - - - - ko00000,ko01000,ko03000,ko03400 - - - Ada_Zn_binding,DNA_binding_1,HTH_18,Methyltransf_1N k59_1026645_2 502558.EGYY_23000 2.07e-06 50.8 COG2197@1|root,COG2197@2|Bacteria,2HF79@201174|Actinobacteria,4CXNW@84998|Coriobacteriia 84998|Coriobacteriia KT helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE k59_173390_1 1125863.JAFN01000001_gene1650 4.51e-86 268.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WJ88@28221|Deltaproteobacteria 28221|Deltaproteobacteria T two component, sigma54 specific, transcriptional regulator, Fis family ntrX - - ko:K13599 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_940584_1 1452718.JBOY01000180_gene1258 4.23e-89 286.0 COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,1RQA8@1236|Gammaproteobacteria 1236|Gammaproteobacteria L DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase dnaE2 GO:0003674,GO:0003824,GO:0003887,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576 2.7.7.7 ko:K14162 - - - - ko00000,ko01000,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_471709_1 1128421.JAGA01000003_gene3073 0.000125 49.7 COG1572@1|root,COG4655@1|root,COG5434@1|root,COG1572@2|Bacteria,COG4655@2|Bacteria,COG5434@2|Bacteria 2|Bacteria M polygalacturonase activity - - - - - - - - - - - - Beta_helix,CARDB,CBM_35,DUF11,F5_F8_type_C,Pectate_lyase_3,Tad k59_1026670_1 1485544.JQKP01000001_gene1298 1.92e-19 85.1 COG4137@1|root,COG4137@2|Bacteria,1R3YD@1224|Proteobacteria,2VK0H@28216|Betaproteobacteria,44V5D@713636|Nitrosomonadales 28216|Betaproteobacteria S Cytochrome C assembly protein ypjD - - - - - - - - - - - Cytochrom_C_asm k59_1026670_2 1304883.KI912532_gene1509 2.42e-52 179.0 COG4536@1|root,COG4536@2|Bacteria,1NZ99@1224|Proteobacteria,2WGFR@28216|Betaproteobacteria,2KV1H@206389|Rhodocyclales 206389|Rhodocyclales P Transporter associated domain - - - - - - - - - - - - CBS,CorC_HlyC,DUF21 k59_301960_1 765913.ThidrDRAFT_0049 5.65e-82 255.0 COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,1MU60@1224|Proteobacteria,1RNRD@1236|Gammaproteobacteria,1WWFA@135613|Chromatiales 135613|Chromatiales E PFAM Prephenate dehydratase - - 4.2.1.51,5.4.99.5 ko:K14170 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024,M00025 R00691,R01373,R01715 RC00360,RC03116 ko00000,ko00001,ko00002,ko01000 - - - ACT,CM_2,PDT k59_1281494_1 519989.ECTPHS_10346 1.03e-82 251.0 COG1573@1|root,COG1573@2|Bacteria,1MW91@1224|Proteobacteria,1S2B6@1236|Gammaproteobacteria 1236|Gammaproteobacteria L uracil-DNA glycosylase - - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_391196_1 1132836.RCCGE510_19538 1.02e-13 75.9 COG3705@1|root,COG3705@2|Bacteria,1QU4P@1224|Proteobacteria,2TVZF@28211|Alphaproteobacteria,4BA90@82115|Rhizobiaceae 28211|Alphaproteobacteria E Domain of unknown function (DUF4175) - - - - - - - - - - - - DUF4175 k59_434265_1 1304275.C41B8_00025 7.78e-44 159.0 COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,1RN5R@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS proS GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004827,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006433,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0043906,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iUTI89_1310.UTI89_C0210 HGTP_anticodon,tRNA-synt_2b,tRNA_edit k59_606601_1 420324.KI911934_gene172 4.1e-95 287.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,1JXEF@119045|Methylobacteriaceae 28211|Alphaproteobacteria L Transposase - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_903052_1 1535422.ND16A_1815 1.34e-39 145.0 COG2132@1|root,COG2132@2|Bacteria 2|Bacteria Q Multicopper oxidase - - - - - - - - - - - - Cu-oxidase_2,Cu-oxidase_3 k59_519553_1 604331.AUHY01000006_gene831 8.31e-236 664.0 COG0365@1|root,COG0365@2|Bacteria,1WNGH@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus I AMP-binding enzyme C-terminal domain - - 6.2.1.32 ko:K08295 ko00627,ko01120,map00627,map01120 - R00982 RC00004,RC00174 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C k59_519566_1 1380394.JADL01000001_gene2302 5.28e-81 268.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,2TRHQ@28211|Alphaproteobacteria,2JPK2@204441|Rhodospirillales 204441|Rhodospirillales E glutamate synthase gltB - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_1244220_1 1122182.KB903833_gene5429 8.25e-57 198.0 COG1404@1|root,COG4935@1|root,COG1404@2|Bacteria,COG4935@2|Bacteria,2I9U6@201174|Actinobacteria,4DH83@85008|Micromonosporales 201174|Actinobacteria O Proprotein convertase P-domain - - - - - - - - - - - - P_proprotein,Peptidase_S8 k59_1330741_1 1266925.JHVX01000001_gene2483 3.5e-94 287.0 COG1612@1|root,COG1612@2|Bacteria,1MVJ4@1224|Proteobacteria,2WAY9@28216|Betaproteobacteria,371NX@32003|Nitrosomonadales 28216|Betaproteobacteria O Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group ctaA - - ko:K02259 ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714 M00154 R07412 RC00769 ko00000,ko00001,ko00002,ko03029 3.D.4.4 - - COX15-CtaA k59_1244261_1 1211115.ALIQ01000206_gene4728 4.27e-120 359.0 COG0129@1|root,COG0129@2|Bacteria,1MV4I@1224|Proteobacteria,2TQRW@28211|Alphaproteobacteria,3NC3N@45404|Beijerinckiaceae 28211|Alphaproteobacteria EG Dehydratase family ilvD2 - 4.2.1.25 ko:K13875 ko00053,ko01100,map00053,map01100 - R02522 RC00543 ko00000,ko00001,ko01000 - - - ILVD_EDD k59_92530_1 999541.bgla_1g32120 8.16e-87 270.0 COG0144@1|root,COG0144@2|Bacteria,1MV2Q@1224|Proteobacteria,2VI1D@28216|Betaproteobacteria,1K0D5@119060|Burkholderiaceae 28216|Betaproteobacteria J Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family rsmB_2 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005730,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0031974,GO:0031981,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0046483,GO:0070013,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:1901360 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F,Methyltr_RsmF_N k59_350353_1 395963.Bind_0784 6.43e-26 106.0 COG5281@1|root,COG5281@2|Bacteria,1NZ1M@1224|Proteobacteria,2TS08@28211|Alphaproteobacteria,3NANB@45404|Beijerinckiaceae 28211|Alphaproteobacteria D sister chromatid segregation - - - - - - - - - - - - - k59_1244281_2 1121033.AUCF01000028_gene387 2.75e-41 145.0 COG0390@1|root,COG0390@2|Bacteria,1MV2N@1224|Proteobacteria,2U1K9@28211|Alphaproteobacteria,2JSJH@204441|Rhodospirillales 204441|Rhodospirillales S Uncharacterised protein family (UPF0014) - - - ko:K02069 - M00211 - - ko00000,ko00002,ko02000 9.B.25.1 - - UPF0014 k59_221084_1 986075.CathTA2_1522 2.2e-49 174.0 COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,4HADT@91061|Bacilli 91061|Bacilli KT Transcriptional regulator - - - - - - - - - - - - CBS,HTH_8,PAS,PAS_9,Sigma54_activat k59_1075675_1 414684.RC1_3398 7.47e-40 144.0 COG0111@1|root,COG0111@2|Bacteria,1MW1U@1224|Proteobacteria,2TSUU@28211|Alphaproteobacteria,2JPHD@204441|Rhodospirillales 204441|Rhodospirillales EH D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain - - 1.1.1.79,1.1.1.81 ko:K12972 ko00260,ko00620,ko00630,ko01100,ko01110,ko01120,map00260,map00620,map00630,map01100,map01110,map01120 - R00465,R01388,R01392,R02527 RC00031,RC00042,RC00670 ko00000,ko00001,ko01000 - - - 2-Hacid_dh_C k59_1330845_1 488538.SAR116_0005 0.000135 47.8 COG0551@1|root,COG0551@2|Bacteria,1PZFI@1224|Proteobacteria,2UIBA@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Nuclease-related domain - - - - - - - - - - - - NERD,zf-C4_Topoisom k59_218451_2 547045.NEISICOT_01491 6.16e-11 60.5 COG0858@1|root,COG0858@2|Bacteria,1MZPE@1224|Proteobacteria,2VR43@28216|Betaproteobacteria,2KR6I@206351|Neisseriales 206351|Neisseriales J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA rbfA - - ko:K02834 - - - - ko00000,ko03009 - - - RBFA k59_1029904_1 1121104.AQXH01000001_gene2010 1e-23 104.0 COG0248@1|root,COG0248@2|Bacteria,4NH03@976|Bacteroidetes,1IQTS@117747|Sphingobacteriia 976|Bacteroidetes FP PFAM Ppx GppA phosphatase ppx - 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000 - - - HD,Ppx-GppA k59_1198974_1 670487.Ocepr_2061 5.98e-46 168.0 COG3420@1|root,COG3420@2|Bacteria,1WNFU@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus P Right handed beta helix region - - - - - - - - - - - - Beta_helix,DUF11 k59_431754_2 748247.AZKH_0807 3.59e-40 145.0 COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,2VIGA@28216|Betaproteobacteria,2KUKY@206389|Rhodocyclales 206389|Rhodocyclales J histidyl-tRNA synthetase hisS - 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_His k59_305251_1 1229909.NSED_00400 7.95e-70 220.0 COG2132@1|root,arCOG03914@2157|Archaea,41T22@651137|Thaumarchaeota 651137|Thaumarchaeota Q Multicopper oxidase - - 1.7.2.1 ko:K00368 ko00910,ko01120,map00910,map01120 M00529 R00783,R00785 RC00086 ko00000,ko00001,ko00002,ko01000 - - - Copper-bind k59_6963_1 391616.OA238_c28680 4.54e-05 51.2 COG3743@1|root,COG3743@2|Bacteria,1N76A@1224|Proteobacteria,2U93Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria M NADH ubiquinone oxidoreductase 41 kD complex I subunit nuoE_2 - - - - - - - - - - - - k59_687474_1 596154.Alide2_4535 3.83e-55 192.0 COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2VNBU@28216|Betaproteobacteria,4AGM2@80864|Comamonadaceae 28216|Betaproteobacteria C CoA binding domain - - - - - - - - - - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig k59_474341_1 1123060.JONP01000027_gene3492 1.6e-53 183.0 COG1653@1|root,COG1653@2|Bacteria 2|Bacteria G carbohydrate transport - - - ko:K02027,ko:K10117 ko02010,map02010 M00196,M00207 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.28 - - SBP_bac_1,SBP_bac_8 k59_603691_1 1279038.KB907344_gene3614 2.28e-60 209.0 COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,2TQRR@28211|Alphaproteobacteria,2JPD6@204441|Rhodospirillales 204441|Rhodospirillales L This protein is involved in the repair of mismatches in DNA mutS - - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_730105_1 1330700.JQNC01000003_gene156 2.96e-56 189.0 COG0498@1|root,COG0498@2|Bacteria,1WIAX@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus E Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine - - 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_730108_1 1288494.EBAPG3_13730 1.24e-51 174.0 COG0331@1|root,COG0331@2|Bacteria,1MV6N@1224|Proteobacteria,2VJF7@28216|Betaproteobacteria,371NC@32003|Nitrosomonadales 28216|Betaproteobacteria I malonyl CoA-acyl carrier protein transacylase fabD - 2.3.1.39 ko:K00645,ko:K13935,ko:K15355 ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 M00082 R01626,R11671 RC00004,RC00039,RC02727 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyl_transf_1 k59_48950_1 1266925.JHVX01000018_gene1806 2.03e-61 192.0 COG0098@1|root,COG0098@2|Bacteria,1MUS4@1224|Proteobacteria,2VQ80@28216|Betaproteobacteria,3723A@32003|Nitrosomonadales 28216|Betaproteobacteria J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body rpsE - - ko:K02988 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S5,Ribosomal_S5_C k59_48950_2 1123073.KB899242_gene1691 1.49e-13 65.5 COG1841@1|root,COG1841@2|Bacteria,1QBAT@1224|Proteobacteria,1T6V9@1236|Gammaproteobacteria,1X885@135614|Xanthomonadales 135614|Xanthomonadales J Ribosomal protein L30 rpmD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02907 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L30 k59_48950_3 1123256.KB907961_gene520 1.33e-43 145.0 COG0200@1|root,COG0200@2|Bacteria,1RDC8@1224|Proteobacteria,1S3P6@1236|Gammaproteobacteria,1X6FU@135614|Xanthomonadales 135614|Xanthomonadales J Binds to the 23S rRNA rplO GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02876 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27A k59_1199046_1 1282362.AEAC466_04730 4.83e-09 63.5 COG4424@1|root,COG4424@2|Bacteria,1R5G6@1224|Proteobacteria,2UMB7@28211|Alphaproteobacteria,2KIFH@204458|Caulobacterales 204458|Caulobacterales S Aspartyl/Asparaginyl beta-hydroxylase - - - - - - - - - - - - Asp_Arg_Hydrox k59_388766_2 426114.THI_1393 3.61e-55 177.0 COG2030@1|root,COG2030@2|Bacteria,1RIBV@1224|Proteobacteria,2VTGX@28216|Betaproteobacteria,1KKWK@119065|unclassified Burkholderiales 28216|Betaproteobacteria I dehydratase - - - - - - - - - - - - MaoC_dehydratas k59_603746_1 488538.SAR116_1460 2.58e-57 190.0 COG4177@1|root,COG4177@2|Bacteria,1NPII@1224|Proteobacteria,2TVFT@28211|Alphaproteobacteria,4BRDF@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E Branched-chain amino acid transport system permease - - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_603746_2 1469245.JFBG01000097_gene1349 5.42e-32 120.0 COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,1RNDV@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the binding-protein-dependent transport system permease family - - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_985936_1 713587.THITH_12040 1.09e-52 180.0 COG1797@1|root,COG1797@2|Bacteria,1MV7Z@1224|Proteobacteria,1RR1J@1236|Gammaproteobacteria,1WVZY@135613|Chromatiales 135613|Chromatiales H Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source cbiA - 6.3.5.11,6.3.5.9 ko:K02224 ko00860,ko01100,ko01120,map00860,map01100,map01120 - R05224,R05815 RC00010,RC01301 ko00000,ko00001,ko01000 - - - AAA_26,CbiA,GATase_3 k59_985936_2 322710.Avin_28150 8.24e-08 51.2 COG2920@1|root,COG2920@2|Bacteria,1RGVG@1224|Proteobacteria,1S5ZA@1236|Gammaproteobacteria 1236|Gammaproteobacteria P part of a sulfur-relay system tusE GO:0002097,GO:0002098,GO:0002143,GO:0003674,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0097163,GO:0140104,GO:1901360 - ko:K11179 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - DsrC k59_1030084_1 1165096.ARWF01000001_gene1829 4.18e-08 59.7 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KNHH@206350|Nitrosomonadales 206350|Nitrosomonadales T MASE1 - - - - - - - - - - - - EAL,GGDEF,MASE1,PAS,PAS_9 k59_1327693_1 420324.KI911935_gene5475 3.67e-25 106.0 COG3666@1|root,COG3666@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_431900_1 765912.Thimo_2840 3.02e-108 327.0 COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,1RNJV@1236|Gammaproteobacteria,1WWJA@135613|Chromatiales 135613|Chromatiales U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY - - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY k59_773585_1 570952.ATVH01000014_gene1942 6.64e-89 276.0 COG1492@1|root,COG1492@2|Bacteria,1MUFY@1224|Proteobacteria,2TRHI@28211|Alphaproteobacteria,2JPDZ@204441|Rhodospirillales 204441|Rhodospirillales H Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation cobQ - 6.3.5.10 ko:K02232 ko00860,ko01100,map00860,map01100 M00122 R05225 RC00010,RC01302 ko00000,ko00001,ko00002,ko01000 - - - AAA_26,CbiA,GATase_3 k59_1156485_1 713586.KB900536_gene2809 1.86e-20 88.6 COG2085@1|root,COG2085@2|Bacteria,1RCXR@1224|Proteobacteria,1S463@1236|Gammaproteobacteria 1236|Gammaproteobacteria S NADP oxidoreductase, coenzyme f420-dependent - - 1.5.1.40 ko:K06988 - - - - ko00000,ko01000 - - - F420_oxidored k59_1156485_2 1318628.MARLIPOL_16229 9e-85 259.0 COG0656@1|root,COG0656@2|Bacteria,1MX6S@1224|Proteobacteria,1RQA1@1236|Gammaproteobacteria,466RA@72275|Alteromonadaceae 1236|Gammaproteobacteria S COG0656 Aldo keto reductases, related to diketogulonate reductase - - - - - - - - - - - - Aldo_ket_red,TAT_signal k59_1113186_1 1458275.AZ34_13705 2.41e-66 227.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VI3F@28216|Betaproteobacteria,4ACE6@80864|Comamonadaceae 28216|Betaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_1199139_1 765914.ThisiDRAFT_1097 9.96e-46 159.0 COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,1RM7M@1236|Gammaproteobacteria,1WX5B@135613|Chromatiales 135613|Chromatiales J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH - 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 k59_644889_1 1038866.KB902790_gene3478 1.54e-08 60.5 COG3210@1|root,COG3210@2|Bacteria,1MXIP@1224|Proteobacteria,2TTVB@28211|Alphaproteobacteria,3JV1M@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria U TIGRFAM filamentous haemagglutinin family outer membrane protein - - - - - - - - - - - - DUF3739,Haemagg_act k59_1241797_1 1095769.CAHF01000021_gene883 2.81e-106 315.0 COG1319@1|root,COG1319@2|Bacteria,1MUDB@1224|Proteobacteria,2VHV8@28216|Betaproteobacteria 28216|Betaproteobacteria C Dehydrogenase coxM - 1.2.5.3 ko:K03519 - - R11168 RC02800 ko00000,ko01000 - - - CO_deh_flav_C,FAD_binding_5 k59_1241797_2 631454.N177_4200 3.26e-18 83.6 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria,1JNHC@119043|Rhodobiaceae 28211|Alphaproteobacteria C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain coxL - 1.2.5.3 ko:K03520 - - R11168 RC02800 ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_1284159_1 402881.Plav_1769 1.69e-87 265.0 COG1028@1|root,COG1028@2|Bacteria,1MU2T@1224|Proteobacteria,2TSDG@28211|Alphaproteobacteria,1JQ1K@119043|Rhodobiaceae 28211|Alphaproteobacteria IQ KR domain - - 1.1.1.100 ko:K00059,ko:K07535 ko00061,ko00333,ko00362,ko00780,ko01040,ko01100,ko01120,ko01130,ko01212,ko01220,map00061,map00333,map00362,map00780,map01040,map01100,map01120,map01130,map01212,map01220 M00083,M00540,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R05582,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117,RC00154 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_900754_1 107636.JQNK01000009_gene3513 1.03e-77 246.0 COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2TRXG@28211|Alphaproteobacteria,370BU@31993|Methylocystaceae 28211|Alphaproteobacteria L Transposase DDE domain - - - ko:K07487 - - - - ko00000 - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_559246_1 323848.Nmul_A2590 1.69e-57 181.0 COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,2VR66@28216|Betaproteobacteria,37356@32003|Nitrosomonadales 28216|Betaproteobacteria U general secretion pathway protein G gspG2 - - ko:K02456 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl,T2SSG k59_730240_1 1267533.KB906733_gene2906 3.45e-99 300.0 COG0192@1|root,COG0192@2|Bacteria,3Y45C@57723|Acidobacteria,2JJ0A@204432|Acidobacteriia 204432|Acidobacteriia H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme metK - 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N k59_1030199_1 1417296.U879_15655 2.95e-50 169.0 COG0483@1|root,COG0483@2|Bacteria,1MV4W@1224|Proteobacteria,2TV4R@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Inositol monophosphatase suhB2 - 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P k59_260914_1 1297569.MESS2_1020028 1.39e-20 92.0 COG1861@1|root,COG1861@2|Bacteria,1QU5J@1224|Proteobacteria,2U0ZH@28211|Alphaproteobacteria 28211|Alphaproteobacteria L DDE (Asp,Asp,Glu) domain - - - - - - - - - - - - DDE_Tnp_1_4 k59_1327822_1 189753.AXAS01000041_gene2534 1.08e-38 140.0 COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S ABC transporter substrate binding protein - - - ko:K01989 - M00247 - - ko00000,ko00002,ko02000 - - - ABC_sub_bind k59_1156578_1 926550.CLDAP_19240 1.15e-70 223.0 COG0543@1|root,COG0543@2|Bacteria,2G7HU@200795|Chloroflexi 200795|Chloroflexi C Oxidoreductase NAD-binding domain - - 1.18.1.3 ko:K15765 ko00623,ko00920,ko01100,ko01120,ko01220,map00623,map00920,map01100,map01120,map01220 M00538 R02550,R03562,R05666,R09513 RC00269,RC00490,RC02556 ko00000,ko00001,ko00002,ko01000 - - - DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1 k59_1113260_1 935840.JAEQ01000009_gene1332 1.1e-67 225.0 COG0028@1|root,COG0028@2|Bacteria,1MX3Q@1224|Proteobacteria,2U2RW@28211|Alphaproteobacteria,43GZZ@69277|Phyllobacteriaceae 28211|Alphaproteobacteria EH PFAM thiamine pyrophosphate enzyme-like TPP-binding thiamine pyrophosphate - - - - - - - - - - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1327829_1 402881.Plav_2836 1.03e-90 275.0 COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,2TRHP@28211|Alphaproteobacteria,1JN0H@119043|Rhodobiaceae 28211|Alphaproteobacteria F Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain pyrB GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_943471_1 1000565.METUNv1_02313 6.83e-39 147.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2VH0Y@28216|Betaproteobacteria,2KU6T@206389|Rhodocyclales 206389|Rhodocyclales I 3-hydroxyacyl-CoA dehydrogenase - - 1.1.1.35,4.2.1.17,5.1.2.3 ko:K01782 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_218781_1 1123288.SOV_6c02680 8.17e-60 203.0 COG0845@1|root,COG0845@2|Bacteria,1U1UF@1239|Firmicutes,4H27Y@909932|Negativicutes 909932|Negativicutes M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K18302 - M00642 - - ko00000,ko00002,ko01504,ko02000 2.A.6.2,8.A.1 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_1241942_2 1127518.H9C0Z3_9CAUD 2.11e-91 283.0 4QATB@10239|Viruses,4QVUZ@35237|dsDNA viruses no RNA stage,4QPGA@28883|Caudovirales,4QI8J@10662|Myoviridae 10662|Myoviridae S metabolic process - - - - - - - - - - - - - k59_818632_2 264198.Reut_B5561 0.000842 41.6 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VI4Q@28216|Betaproteobacteria,1K0B4@119060|Burkholderiaceae 28216|Betaproteobacteria O Belongs to the peptidase S1C family mucD - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_563177_1 441620.Mpop_2821 1.03e-12 67.8 COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,2TRQN@28211|Alphaproteobacteria,1JT21@119045|Methylobacteriaceae 28211|Alphaproteobacteria K Participates in both transcription termination and antitermination nusA - - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - HHH_5,KH_5,NusA_N,S1 k59_563177_2 414684.RC1_2909 2.98e-53 176.0 COG0779@1|root,COG0779@2|Bacteria,1RDP2@1224|Proteobacteria,2TS4E@28211|Alphaproteobacteria,2JSSI@204441|Rhodospirillales 204441|Rhodospirillales S Required for maturation of 30S ribosomal subunits rimP - - ko:K09748 - - - - ko00000,ko03009 - - - DUF150,DUF150_C k59_436448_2 1348657.M622_11920 7.61e-109 322.0 COG1414@1|root,COG1414@2|Bacteria,1MUNW@1224|Proteobacteria,2VHB6@28216|Betaproteobacteria,2KUMZ@206389|Rhodocyclales 206389|Rhodocyclales K Transcriptional regulator - - - - - - - - - - - - HTH_IclR,IclR k59_990506_2 1236976.JCM16418_2112 1.1e-23 98.2 COG1089@1|root,COG1089@2|Bacteria,1TQ9T@1239|Firmicutes,4HB2M@91061|Bacilli,26S2Z@186822|Paenibacillaceae 91061|Bacilli M Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose gmd - 4.2.1.47 ko:K01711 ko00051,ko00520,ko01100,map00051,map00520,map01100 - R00888 RC00402 ko00000,ko00001,ko01000 - - - GDP_Man_Dehyd k59_11999_1 1095769.CAHF01000014_gene3048 2.35e-87 265.0 COG0476@1|root,COG0476@2|Bacteria,1MW7H@1224|Proteobacteria,2VI1U@28216|Betaproteobacteria,472XC@75682|Oxalobacteraceae 28216|Betaproteobacteria H ThiF family thiF - 2.7.7.80 ko:K21029 ko04122,map04122 - R07459 RC00043 ko00000,ko00001,ko01000 - - - ThiF k59_310957_1 979556.MTES_1491 1.85e-45 164.0 COG0515@1|root,COG0515@2|Bacteria,2GMPZ@201174|Actinobacteria,4FM1Q@85023|Microbacteriaceae 201174|Actinobacteria KLT Protein tyrosine kinase pknA - 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase k59_692196_2 292415.Tbd_2027 3.56e-19 82.0 COG2863@1|root,COG2863@2|Bacteria,1MZU1@1224|Proteobacteria,2VU50@28216|Betaproteobacteria 28216|Betaproteobacteria C PFAM Cytochrome c, class I cytC2 - - - - - - - - - - - Cytochrom_C,Cytochrome_CBB3 k59_1203693_1 748280.NH8B_2972 1.44e-78 248.0 COG1055@1|root,COG1055@2|Bacteria,1NEVR@1224|Proteobacteria,2VM0X@28216|Betaproteobacteria,2KSQI@206351|Neisseriales 206351|Neisseriales P Citrate transporter - - - - - - - - - - - - CitMHS k59_310980_1 1057002.KB905371_gene410 2.91e-81 256.0 COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2TRXG@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase - - - ko:K07487 - - - - ko00000 - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_223138_1 935840.JAEQ01000020_gene2336 1.8e-93 290.0 COG0526@1|root,COG0526@2|Bacteria,1RC8N@1224|Proteobacteria,2U7IW@28211|Alphaproteobacteria,43NJ4@69277|Phyllobacteriaceae 28211|Alphaproteobacteria CO COG0526, thiol-disulfide isomerase and thioredoxins - - - - - - - - - - - - AhpC-TSA k59_223142_2 1453501.JELR01000002_gene342 3.41e-17 81.6 COG1361@1|root,COG4932@1|root,COG1361@2|Bacteria,COG4932@2|Bacteria,1R5G4@1224|Proteobacteria,1SEWA@1236|Gammaproteobacteria,469S7@72275|Alteromonadaceae 1236|Gammaproteobacteria M Domain of unknown function DUF11 - - - - - - - - - - - - DUF11,SdrD_B k59_479056_1 648757.Rvan_1283 6e-47 159.0 COG0500@1|root,COG2226@2|Bacteria,1PVPS@1224|Proteobacteria,2TREE@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q ubiquinone menaquinone biosynthesis methyltransferase - - - - - - - - - - - - Methyltransf_11,Methyltransf_25,Methyltransf_31 k59_479056_2 1043493.BBLU01000002_gene1720 3.74e-31 120.0 COG0493@1|root,COG1144@1|root,COG0493@2|Bacteria,COG1144@2|Bacteria,2GJ0A@201174|Actinobacteria 201174|Actinobacteria E Glutamate synthase preT - - - - - - - - - - - Fer4,Fer4_20,Pyr_redox_2,Pyr_redox_3 k59_136875_1 1132855.KB913035_gene1982 4.94e-10 67.8 COG3307@1|root,COG3307@2|Bacteria,1MYWJ@1224|Proteobacteria,2VKZA@28216|Betaproteobacteria 28216|Betaproteobacteria M O-Antigen Polymerase - - - - - - - - - - - - PglL_A,Wzy_C,Wzy_C_2 k59_136875_2 1286632.P278_04640 3.54e-15 72.4 COG0500@1|root,COG2226@2|Bacteria,4NYM9@976|Bacteroidetes,1I5IP@117743|Flavobacteriia 976|Bacteroidetes Q ubiE/COQ5 methyltransferase family - - - - - - - - - - - - Methyltransf_11 k59_1333329_1 1121035.AUCH01000002_gene1474 4.58e-14 72.4 COG0664@1|root,COG0664@2|Bacteria,1R5P7@1224|Proteobacteria,2VIQI@28216|Betaproteobacteria,2KVHP@206389|Rhodocyclales 206389|Rhodocyclales K COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases - - - ko:K21563 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding k59_1288608_1 680198.SCAB_12541 1.17e-31 124.0 COG3387@1|root,COG3387@2|Bacteria,2GJAD@201174|Actinobacteria 201174|Actinobacteria G Glycoside hydrolase - - - - - - - - - - - - Glyco_hydro_15 k59_1288608_2 296591.Bpro_3704 6.27e-30 112.0 2DQ60@1|root,334WQ@2|Bacteria,1NADI@1224|Proteobacteria,2VUFT@28216|Betaproteobacteria,4AFA4@80864|Comamonadaceae 28216|Betaproteobacteria S Protein of Unknown function (DUF2784) - - - - - - - - - - - - DUF2784 k59_649410_1 85643.Tmz1t_3386 1.88e-72 232.0 COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,2VI8D@28216|Betaproteobacteria,2KVNI@206389|Rhodocyclales 206389|Rhodocyclales S GTPase that plays an essential role in the late steps of ribosome biogenesis der - - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 k59_94480_1 1123060.JONP01000001_gene1375 2.22e-46 169.0 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria,2JQY7@204441|Rhodospirillales 204441|Rhodospirillales C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - 1.2.5.3 ko:K03520 - - R11168 RC02800 ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_352982_1 394221.Mmar10_1206 1.17e-08 58.9 COG1286@1|root,COG1286@2|Bacteria,1N80D@1224|Proteobacteria,2VA4F@28211|Alphaproteobacteria,43YJA@69657|Hyphomonadaceae 28211|Alphaproteobacteria S Colicin V production protein - - - ko:K03558 - - - - ko00000 - - - Colicin_V k59_352982_2 1244869.H261_06896 4.53e-07 50.1 COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,2TR8V@28211|Alphaproteobacteria,2JPC6@204441|Rhodospirillales 204441|Rhodospirillales F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF - 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase_6,GATase_7,Pribosyltran k59_1333426_1 1122221.JHVI01000017_gene2080 1.48e-18 90.1 COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,1WKHY@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus T PFAM Bacterial transcriptional activator domain - - - - - - - - - - - - AAA_16,BTAD,TPR_8 k59_393637_1 795666.MW7_1966 6.92e-42 149.0 COG1559@1|root,COG1559@2|Bacteria,1MUQF@1224|Proteobacteria,2VHD4@28216|Betaproteobacteria,1K15A@119060|Burkholderiaceae 28216|Betaproteobacteria S Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation mltG - - ko:K07082 - - - - ko00000 - - - YceG k59_1078412_1 522306.CAP2UW1_3743 4.09e-78 236.0 COG0782@1|root,COG0782@2|Bacteria,1RCXW@1224|Proteobacteria,2VQ16@28216|Betaproteobacteria,1KPYW@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides greA - - ko:K03624 - - - - ko00000,ko03021 - - - GreA_GreB,GreA_GreB_N k59_1246564_1 1121952.ATXT01000016_gene690 1.33e-08 55.8 COG0015@1|root,COG0015@2|Bacteria,2GM71@201174|Actinobacteria,4FKK9@85023|Microbacteriaceae 201174|Actinobacteria F Adenylosuccinate lyase C-terminal purB - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ASL_C,Lyase_1 k59_1246564_2 640081.Dsui_3326 5.87e-145 417.0 COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,2VHZG@28216|Betaproteobacteria,2KVVV@206389|Rhodocyclales 206389|Rhodocyclales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secF - - ko:K03074 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_1246564_3 1454004.AW11_01653 2.88e-59 199.0 COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,2VHKD@28216|Betaproteobacteria,1KQEU@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD-TM1,SecD_SecF,Sec_GG k59_1203893_1 1502852.FG94_00625 5.83e-64 221.0 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,2VJEX@28216|Betaproteobacteria,476HV@75682|Oxalobacteraceae 28216|Betaproteobacteria NU Neisseria PilC beta-propeller domain pilY1 - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC k59_1333513_1 224911.27352466 1.05e-33 123.0 COG1116@1|root,COG1116@2|Bacteria,1MUIM@1224|Proteobacteria,2TRHM@28211|Alphaproteobacteria,3JR64@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P ATPases associated with a variety of cellular activities MA20_28765 - - ko:K02049 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - ABC_tran k59_1333513_2 335659.S23_40560 1.65e-20 89.0 COG0600@1|root,COG0600@2|Bacteria,1MVAE@1224|Proteobacteria,2U18X@28211|Alphaproteobacteria,3JTGT@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P Binding-protein-dependent transport system inner membrane component MA20_28785 - - ko:K02050 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - BPD_transp_1 k59_860936_2 1366050.N234_11925 1.21e-08 65.1 COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,2VIK6@28216|Betaproteobacteria,1K0WB@119060|Burkholderiaceae 28216|Betaproteobacteria S biosynthesis protein E pqqE - - ko:K06139 - - - - ko00000 - - - Fer4_12,Fer4_14,Radical_SAM,SPASM k59_264409_1 1479238.JQMZ01000001_gene104 5.19e-31 119.0 COG1208@1|root,COG1208@2|Bacteria,1R9ZD@1224|Proteobacteria,2TU2V@28211|Alphaproteobacteria,43XF5@69657|Hyphomonadaceae 28211|Alphaproteobacteria JM COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits (eIF-2Bgamma eIF-2Bepsilon) MA20_24100 - 2.7.7.13,2.7.7.99 ko:K00966,ko:K00992 ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110 M00114,M00361,M00362 R00885,R11025 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transf_3,NTP_transferase k59_860948_1 1298867.AUES01000067_gene5125 4.96e-23 102.0 COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TTJ0@28211|Alphaproteobacteria,3JS5D@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - GAF_2,HAMP,HATPase_c,HisKA,PAS_7,dCache_1 k59_478509_1 1121948.AUAC01000002_gene1256 3.14e-85 276.0 COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2TQVK@28211|Alphaproteobacteria,43WFJ@69657|Hyphomonadaceae 28211|Alphaproteobacteria C COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL homologs MA20_34355 - 1.3.99.16 ko:K07303 - - - - ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_352261_2 228405.HNE_2125 3.75e-10 60.8 COG1540@1|root,COG1540@2|Bacteria,1MUYV@1224|Proteobacteria,2TQUC@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Belongs to the UPF0271 (lamB) family - - - ko:K07160 - - - - ko00000 - - - LamB_YcsF k59_947368_1 1410626.JHXB01000007_gene2578 8.96e-35 136.0 COG1193@1|root,COG1193@2|Bacteria,1TP5W@1239|Firmicutes,248YK@186801|Clostridia,27ID1@186928|unclassified Lachnospiraceae 186801|Clostridia L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity mutS2 - - ko:K07456 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_V,Smr k59_1160561_1 571166.KI421509_gene3730 4.62e-41 139.0 COG3415@1|root,COG3415@2|Bacteria,1ND8F@1224|Proteobacteria 1224|Proteobacteria L Transposase - - - - - - - - - - - - HTH_28,HTH_Tnp_IS630 k59_11517_1 406817.XNC1_4085 7.03e-15 80.1 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,1RP9N@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell glnE GO:0000166,GO:0000287,GO:0000820,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006521,GO:0006541,GO:0006542,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0008882,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0010565,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0019222,GO:0019752,GO:0030554,GO:0031323,GO:0032553,GO:0032555,GO:0032559,GO:0033238,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0070566,GO:0071704,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_608682_1 1232410.KI421425_gene1564 2.38e-73 235.0 COG5557@1|root,COG5557@2|Bacteria,1PFX4@1224|Proteobacteria,42PIE@68525|delta/epsilon subdivisions,2WM3C@28221|Deltaproteobacteria,43SBI@69541|Desulfuromonadales 28221|Deltaproteobacteria C Polysulphide reductase, NrfD moz - - ko:K00185 - - - - ko00000 5.A.3 - - DUF3341,NrfD k59_222647_1 1208583.COMX_05160 7.66e-51 171.0 COG1351@1|root,COG1351@2|Bacteria,1MWY8@1224|Proteobacteria,2TTER@28211|Alphaproteobacteria,2JQGP@204441|Rhodospirillales 204441|Rhodospirillales F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant thyX - 2.1.1.148 ko:K03465 ko00240,ko00670,ko01100,map00240,map00670,map01100 - R06613 RC00022,RC00332 ko00000,ko00001,ko01000 - - - Thy1 k59_691720_1 519989.ECTPHS_10119 2.27e-83 255.0 COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,1RMEX@1236|Gammaproteobacteria,1WWPK@135613|Chromatiales 135613|Chromatiales C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family - - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_222664_1 1178482.BJB45_14995 5.32e-103 304.0 COG3637@1|root,COG3637@2|Bacteria,1R3Z1@1224|Proteobacteria,1S22U@1236|Gammaproteobacteria,1XN5N@135619|Oceanospirillales 135619|Oceanospirillales M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - - - - - - - - - - - k59_1332732_1 945713.IALB_2036 1.69e-92 284.0 COG0205@1|root,COG0205@2|Bacteria 2|Bacteria G 6-phosphofructokinase activity pfp GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0006002,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008443,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019637,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0046835,GO:0046872,GO:0047334,GO:0071704,GO:1901135 2.7.1.11,2.7.1.90 ko:K00850,ko:K00895,ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230 M00001,M00345 R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko01009,ko03019 - - - PFK k59_648877_1 468059.AUHA01000003_gene1482 8.14e-24 107.0 COG0793@1|root,COG0793@2|Bacteria,4NN5N@976|Bacteroidetes,1J0BV@117747|Sphingobacteriia 976|Bacteroidetes M Domain present in PSD-95, Dlg, and ZO-1/2. - - - - - - - - - - - - Peptidase_S41 k59_1203242_1 1287116.X734_00600 6.19e-33 118.0 COG3415@1|root,COG3415@2|Bacteria,1RJ69@1224|Proteobacteria,2UCXQ@28211|Alphaproteobacteria,43REE@69277|Phyllobacteriaceae 28211|Alphaproteobacteria L 'Paired box' domain - - - ko:K07499 - - - - ko00000 - - - HTH_23,HTH_28,HTH_32,HTH_Tnp_IS630,HTH_Tnp_Tc3_2 k59_1203242_2 384765.SIAM614_19726 2.1e-87 266.0 COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1P76X@1224|Proteobacteria,2U16U@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase - - - ko:K07494 - - - - ko00000 - - - DDE_3 k59_1035199_1 1026882.MAMP_01338 2.09e-57 200.0 COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,1RPXX@1236|Gammaproteobacteria,45ZVX@72273|Thiotrichales 72273|Thiotrichales C CoA binding domain - - - - - - - - - - - - ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig k59_393092_1 1408428.JNJP01000014_gene922 4.44e-37 140.0 COG4091@1|root,COG4091@2|Bacteria,1MUZX@1224|Proteobacteria,42NVM@68525|delta/epsilon subdivisions,2WJHT@28221|Deltaproteobacteria,2MFBY@213115|Desulfovibrionales 28221|Deltaproteobacteria E homoserine dehydrogenase - - - - - - - - - - - - NAD_binding_3 k59_818359_2 522306.CAP2UW1_2826 5.34e-62 211.0 COG0398@1|root,COG1249@1|root,COG0398@2|Bacteria,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2VH3T@28216|Betaproteobacteria,1KQAC@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria C SNARE associated Golgi protein merA - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim,SNARE_assoc k59_990163_1 1200567.JNKD01000016_gene1143 4.25e-92 300.0 COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1Y3YB@135624|Aeromonadales 135624|Aeromonadales E glutamate synthase gltB - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_990166_1 570967.JMLV01000005_gene33 2.96e-125 367.0 COG1960@1|root,COG1960@2|Bacteria,1MX17@1224|Proteobacteria,2TTRE@28211|Alphaproteobacteria,2JRJN@204441|Rhodospirillales 204441|Rhodospirillales I Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1246017_1 1207063.P24_03835 2.01e-91 278.0 COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,2TQSN@28211|Alphaproteobacteria,2JQ78@204441|Rhodospirillales 204441|Rhodospirillales E Aminotransferase class-V - - 2.6.1.44,2.6.1.45,2.6.1.51 ko:K00830 ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146 M00346,M00532 R00369,R00372,R00585,R00588 RC00006,RC00008,RC00018 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 k59_264579_1 1121434.AULY01000009_gene2244 1.17e-22 96.7 COG0697@1|root,COG0697@2|Bacteria,1RCED@1224|Proteobacteria,42QVG@68525|delta/epsilon subdivisions,2WNKA@28221|Deltaproteobacteria,2M9AG@213115|Desulfovibrionales 28221|Deltaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA k59_478709_1 391616.OA238_c24610 1.72e-41 149.0 COG0697@1|root,COG0697@2|Bacteria,1RFZW@1224|Proteobacteria,2TRXD@28211|Alphaproteobacteria 28211|Alphaproteobacteria EG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - - - - - - - - - - EamA k59_136578_1 1000565.METUNv1_03399 1.69e-64 202.0 COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,2VHY3@28216|Betaproteobacteria,2KVAA@206389|Rhodocyclales 206389|Rhodocyclales F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) queC - 6.3.4.20 ko:K06920 ko00790,ko01100,map00790,map01100 - R09978 RC00959 ko00000,ko00001,ko01000,ko03016 - - - QueC k59_136578_2 159087.Daro_4051 8.61e-09 59.7 COG1729@1|root,COG1729@2|Bacteria,1MUSV@1224|Proteobacteria,2VIPC@28216|Betaproteobacteria,2KW31@206389|Rhodocyclales 206389|Rhodocyclales D Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division cpoB - - - - - - - - - - - TPR_6,TolA_bind_tri k59_608941_1 365044.Pnap_1701 5.5e-136 407.0 COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,2VI3K@28216|Betaproteobacteria,4AA75@80864|Comamonadaceae 28216|Betaproteobacteria C Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase,OmpA k59_521453_1 883126.HMPREF9710_04308 5.52e-51 183.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2VH8J@28216|Betaproteobacteria,472ZK@75682|Oxalobacteraceae 28216|Betaproteobacteria P heavy metal translocating P-type ATPase copA - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase k59_521453_2 887062.HGR_14704 2.7e-08 52.0 COG2608@1|root,COG2608@2|Bacteria,1NGBD@1224|Proteobacteria,2VXTQ@28216|Betaproteobacteria 28216|Betaproteobacteria P Heavy metal transport detoxification protein copZ - - ko:K07213 ko04978,map04978 - - - ko00000,ko00001 - - - HMA k59_478768_1 1330700.JQNC01000003_gene51 1.06e-27 114.0 COG4585@1|root,COG4585@2|Bacteria,1WJNH@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF,GAF_2,GAF_3,HATPase_c,HisKA_3,PAS,PAS_4,PAS_8 k59_352560_2 1279038.KB907340_gene1724 1.21e-16 79.0 COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,2TRPB@28211|Alphaproteobacteria,2JPWI@204441|Rhodospirillales 204441|Rhodospirillales H DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity dnaX - 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNA_pol3_gamma3,DUF3646 k59_691962_2 1379270.AUXF01000002_gene1191 1.77e-45 163.0 COG0592@1|root,COG0592@2|Bacteria,1ZT22@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria - - 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_3 k59_1160838_1 402881.Plav_1773 3.82e-145 421.0 COG4638@1|root,COG4638@2|Bacteria,1RBGZ@1224|Proteobacteria,2U82S@28211|Alphaproteobacteria 28211|Alphaproteobacteria P COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit - - - - - - - - - - - - Rieske,Ring_hydroxyl_A k59_1203482_1 1123504.JQKD01000013_gene1006 9.3e-99 311.0 COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2VHUG@28216|Betaproteobacteria,4ABBZ@80864|Comamonadaceae 28216|Betaproteobacteria S Tripartite ATP-independent periplasmic transporter, DctM component - - - - - - - - - - - - DUF3394,DctM k59_1160847_1 688269.Theth_0810 7.72e-46 159.0 COG0037@1|root,COG0037@2|Bacteria,2GCKT@200918|Thermotogae 200918|Thermotogae H Belongs to the TtcA family - - 2.8.1.15 ko:K21947 - - - - ko00000,ko01000,ko03016 - - - ATP_bind_3 k59_1288324_1 944481.JAFP01000001_gene1493 6.95e-103 308.0 COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,42MWZ@68525|delta/epsilon subdivisions,2WJ2B@28221|Deltaproteobacteria,2M6A0@213113|Desulfurellales 28221|Deltaproteobacteria J GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 k59_947665_2 393595.ABO_0366 2.4e-116 345.0 COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,1RPKC@1236|Gammaproteobacteria,1XHJ0@135619|Oceanospirillales 135619|Oceanospirillales J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) tyrS - 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - S4,tRNA-synt_1b k59_947670_1 296591.Bpro_4805 1.53e-61 202.0 COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,2VJ2W@28216|Betaproteobacteria 28216|Betaproteobacteria S Transposase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_649137_2 3659.XP_004142063.1 3.57e-29 114.0 COG1011@1|root,KOG3109@2759|Eukaryota,37PQK@33090|Viridiplantae,3G873@35493|Streptophyta,4JNF4@91835|fabids 35493|Streptophyta S Haloacid dehalogenase-like hydrolase - - - ko:K07025,ko:K18551 ko00760,map00760 - R02323,R03346 RC00017 ko00000,ko00001,ko01000 - - - HAD_2,Hydrolase_like k59_1160879_1 1166948.JPZL01000003_gene497 2.23e-09 57.8 COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,1RMI2@1236|Gammaproteobacteria,1XHK6@135619|Oceanospirillales 135619|Oceanospirillales E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine lysA - 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_1160879_3 522306.CAP2UW1_0410 3.78e-16 73.2 COG1965@1|root,COG1965@2|Bacteria,1RH9A@1224|Proteobacteria,2VVS3@28216|Betaproteobacteria 28216|Betaproteobacteria P Belongs to the frataxin family cyaY - - ko:K06202 - - - - ko00000 - - - Frataxin_Cyay k59_861239_1 1445613.JALM01000005_gene1166 1.12e-67 213.0 COG3826@1|root,COG3826@2|Bacteria,2GK65@201174|Actinobacteria,4DZV5@85010|Pseudonocardiales 201174|Actinobacteria S Oxygenase, catalysing oxidative methylation of damaged DNA - - - ko:K09990 - - - - ko00000 - - - Oxygenase-NA k59_1333064_1 1121033.AUCF01000010_gene4526 2.57e-86 266.0 COG2221@1|root,COG2221@2|Bacteria,1MWY5@1224|Proteobacteria,2U4HS@28211|Alphaproteobacteria,2JVB1@204441|Rhodospirillales 204441|Rhodospirillales C Nitrite and sulphite reductase 4Fe-4S domain - - 1.8.99.5 ko:K11180 ko00633,ko00920,ko01100,ko01120,map00633,map00920,map01100,map01120 M00596 R00295,R00861,R08035 RC00065,RC01760 ko00000,ko00001,ko00002,ko01000 - - - NIR_SIR,NIR_SIR_ferr k59_436326_1 640081.Dsui_0112 6.73e-39 143.0 COG0515@1|root,COG0664@1|root,COG0515@2|Bacteria,COG0664@2|Bacteria,1MV1P@1224|Proteobacteria,2VIE9@28216|Betaproteobacteria,2KU89@206389|Rhodocyclales 206389|Rhodocyclales KLT serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase,cNMP_binding k59_436326_2 1163617.SCD_n02922 6.59e-33 127.0 COG0643@1|root,COG0784@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,2VJSZ@28216|Betaproteobacteria 28216|Betaproteobacteria T Histidine kinase pilL - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_609100_1 694429.Pyrfu_0938 1.16e-18 84.0 COG2220@1|root,arCOG00497@2157|Archaea,2XPSC@28889|Crenarchaeota 28889|Crenarchaeota S Belongs to the UPF0173 family - - - - - - - - - - - - Lactamase_B_2,Lactamase_B_3 k59_609100_2 1410634.JHVD01000014_gene490 1.1e-09 61.2 COG0389@1|root,COG0389@2|Bacteria,2GKBI@201174|Actinobacteria,4DN0X@85009|Propionibacteriales 201174|Actinobacteria L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII dinB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.7.7.7 ko:K02346 - - - - ko00000,ko01000,ko03400 - - - HHH_5,IMS,IMS_C,IMS_HHH k59_11855_1 688245.CtCNB1_1023 7.76e-49 169.0 COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,2VH9T@28216|Betaproteobacteria,4A9SN@80864|Comamonadaceae 28216|Betaproteobacteria E homoserine dehydrogenase hom - 1.1.1.3 ko:K00003 ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00017,M00018 R01773,R01775 RC00087 ko00000,ko00001,ko00002,ko01000 - - - ACT,Homoserine_dh,NAD_binding_3 k59_11855_2 640081.Dsui_2909 2.6e-71 226.0 COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,2VI7S@28216|Betaproteobacteria,2KXUT@206389|Rhodocyclales 206389|Rhodocyclales E Aminotransferase class I and II - - - ko:K14261 - - - - ko00000,ko01000,ko01007 - - - Aminotran_1_2 k59_310781_1 1121440.AUMA01000002_gene2225 1.36e-12 69.3 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WJ88@28221|Deltaproteobacteria,2M91Y@213115|Desulfovibrionales 28221|Deltaproteobacteria T PFAM sigma-54 factor interaction domain-containing protein ntrX - - ko:K13599 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_779001_1 670307.HYPDE_23903 1.38e-21 96.7 COG1183@1|root,COG1183@2|Bacteria,1MWD9@1224|Proteobacteria,2TUF7@28211|Alphaproteobacteria,3N93D@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pssA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.8.8 ko:K17103 ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110 M00093 R01800 RC00002,RC00017,RC02795 ko00000,ko00001,ko00002,ko01000 - - - CDP-OH_P_tran_2,CDP-OH_P_transf k59_54603_1 977880.RALTA_A2531 1.66e-142 412.0 COG0538@1|root,COG0538@2|Bacteria,1MW3J@1224|Proteobacteria,2VHVD@28216|Betaproteobacteria,1K0EF@119060|Burkholderiaceae 28216|Betaproteobacteria C Isocitrate dehydrogenase icd GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_478901_3 348824.LPU83_1704 3.5e-22 95.9 2BSKA@1|root,32MNV@2|Bacteria,1PFD2@1224|Proteobacteria,2V6B6@28211|Alphaproteobacteria,4BGN5@82115|Rhizobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_54625_1 1157708.KB907450_gene5826 6.4e-115 348.0 COG0296@1|root,COG0296@2|Bacteria,1MVM7@1224|Proteobacteria,2VJDX@28216|Betaproteobacteria,4AA76@80864|Comamonadaceae 28216|Betaproteobacteria G SMART alpha amylase catalytic sub domain treZ - 3.2.1.141 ko:K01236 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11256 RC00049 ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48,DUF3459 k59_54625_2 1285583.CCASEI_05705 1.82e-09 60.8 COG1523@1|root,COG1523@2|Bacteria,2GJ00@201174|Actinobacteria,22KHA@1653|Corynebacteriaceae 201174|Actinobacteria G Belongs to the glycosyl hydrolase 13 family glgX - 3.2.1.68 ko:K01214 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11261 - ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48 k59_1203586_3 1129194.I3PGT7_9CAUD 1.47e-195 563.0 4QFP5@10239|Viruses,4QWU1@35237|dsDNA viruses no RNA stage,4QSRX@28883|Caudovirales,4QJQA@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_1203586_4 1088721.NSU_0753 4.42e-34 126.0 2D0K9@1|root,32T8S@2|Bacteria,1MZRW@1224|Proteobacteria,2UDZH@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_352738_1 316274.Haur_2569 1.24e-36 139.0 COG0160@1|root,COG0160@2|Bacteria,2G5RV@200795|Chloroflexi,3763X@32061|Chloroflexia 32061|Chloroflexia H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 2.6.1.19,2.6.1.22 ko:K07250 ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120 M00027 R00908,R01648,R04188 RC00006,RC00062,RC00160 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_1035578_1 1248232.BANQ01000100_gene1294 8.96e-19 81.6 2AU0F@1|root,31JKB@2|Bacteria,1RGGF@1224|Proteobacteria,1S5B2@1236|Gammaproteobacteria,1XX7G@135623|Vibrionales 135623|Vibrionales S COG NOG14600 non supervised orthologous group - - - - - - - - - - - - - k59_905189_1 269796.Rru_A1140 1.69e-37 142.0 COG0480@1|root,COG0480@2|Bacteria,1MU2W@1224|Proteobacteria,2TYVK@28211|Alphaproteobacteria,2JPGT@204441|Rhodospirillales 204441|Rhodospirillales J COG0480 Translation elongation factors (GTPases) - - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU k59_521638_1 93220.LV28_10910 6.08e-39 137.0 COG0204@1|root,COG0204@2|Bacteria,1MY51@1224|Proteobacteria,2VNAX@28216|Betaproteobacteria,1K0T7@119060|Burkholderiaceae 28216|Betaproteobacteria I Acyl-transferase nlaB - 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_521638_2 1031711.RSPO_c02870 1.92e-64 202.0 COG0346@1|root,COG0346@2|Bacteria,1RCYX@1224|Proteobacteria,2VR7R@28216|Betaproteobacteria,1K6XN@119060|Burkholderiaceae 28216|Betaproteobacteria E Lactoylglutathione lyase gloA - 4.4.1.5 ko:K01759 ko00620,map00620 - R02530 RC00004,RC00740 ko00000,ko00001,ko01000 - - - Glyoxalase k59_563151_1 1379270.AUXF01000007_gene901 4.08e-73 246.0 COG2217@1|root,COG2608@1|root,COG2217@2|Bacteria,COG2608@2|Bacteria,1ZU8D@142182|Gemmatimonadetes 142182|Gemmatimonadetes P Putative metal-binding domain of cation transport ATPase - - 3.6.3.4 ko:K01533 - - R00086 RC00002 ko00000,ko01000 3.A.3.5 - - ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase k59_223062_1 1123354.AUDR01000015_gene197 2.26e-61 202.0 COG1663@1|root,COG1663@2|Bacteria,1MU8G@1224|Proteobacteria,2VHPG@28216|Betaproteobacteria,1KSJE@119069|Hydrogenophilales 119069|Hydrogenophilales M Tetraacyldisaccharide-1-P 4'-kinase - - 2.7.1.130 ko:K00912 ko00540,ko01100,map00540,map01100 M00060 R04657 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - - LpxK k59_1203626_1 317655.Sala_2561 2.97e-34 134.0 COG0672@1|root,COG2010@1|root,COG0672@2|Bacteria,COG2010@2|Bacteria,1MXHM@1224|Proteobacteria,2U17C@28211|Alphaproteobacteria,2K07Y@204457|Sphingomonadales 204457|Sphingomonadales P permease - - - ko:K07243 - - - - ko00000,ko02000 2.A.108.1,2.A.108.2 - - Cytochrome_CBB3,FTR1 k59_734715_1 1120950.KB892764_gene5640 3.02e-54 193.0 COG2902@1|root,COG2902@2|Bacteria,2GK0C@201174|Actinobacteria,4DNQX@85009|Propionibacteriales 201174|Actinobacteria E Bacterial NAD-glutamate dehydrogenase gdh - 1.4.1.2 ko:K15371 ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100 - R00243 RC00006,RC02799 ko00000,ko00001,ko01000 - - - Bac_GDH k59_609232_1 713586.KB900536_gene2305 2.2e-78 245.0 COG3391@1|root,COG3391@2|Bacteria,1QD5Q@1224|Proteobacteria,1RYUT@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Heme d1 biosynthesis protein NirF nirF GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K19345 - - - - ko00000 - - - Cytochrom_D1 k59_1203636_1 1469245.JFBG01000021_gene1196 3.97e-65 213.0 COG0151@1|root,COG0151@2|Bacteria,1QTYI@1224|Proteobacteria 1224|Proteobacteria F ATP-grasp domain - - - - - - - - - - - - ATP-grasp_4 k59_818632_1 1297863.APJF01000007_gene2538 2.45e-14 75.9 COG0477@1|root,COG2814@2|Bacteria,1MUXC@1224|Proteobacteria,2TRR7@28211|Alphaproteobacteria,3JVCK@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_786395_1 450851.PHZ_c3498 2.7e-30 124.0 COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,2TS89@28211|Alphaproteobacteria,2KFH1@204458|Caulobacterales 204458|Caulobacterales E Dehydrogenase - - 1.4.1.2 ko:K15371 ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100 - R00243 RC00006,RC02799 ko00000,ko00001,ko01000 - - - Bac_GDH k59_616530_1 1121943.KB899991_gene2409 5.71e-42 155.0 COG4191@1|root,COG4191@2|Bacteria,1MWR3@1224|Proteobacteria,1RMH4@1236|Gammaproteobacteria,1XH8P@135619|Oceanospirillales 135619|Oceanospirillales T Histidine kinase - - 2.7.13.3 ko:K15011 ko02020,map02020 M00523 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c k59_568352_1 1267533.KB906736_gene1442 1.71e-72 229.0 COG0515@1|root,COG0515@2|Bacteria,3Y67Y@57723|Acidobacteria 57723|Acidobacteria KLT Protein tyrosine kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase,TPR_12,TPR_8 k59_911250_1 1238182.C882_2091 1.2e-53 177.0 COG0842@1|root,COG0842@2|Bacteria,1MUF4@1224|Proteobacteria,2TRTS@28211|Alphaproteobacteria,2JPRJ@204441|Rhodospirillales 204441|Rhodospirillales V Transport permease protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane k59_1279453_1 570952.ATVH01000019_gene868 2.2e-140 407.0 COG3039@1|root,COG3039@2|Bacteria,1MVTU@1224|Proteobacteria,2TVIR@28211|Alphaproteobacteria,2JUSM@204441|Rhodospirillales 204441|Rhodospirillales L hmm pf01609 - - - - - - - - - - - - DDE_Tnp_1,DUF772 k59_981201_1 264198.Reut_A0770 1.2e-121 359.0 COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,2VH6S@28216|Betaproteobacteria,1K0U6@119060|Burkholderiaceae 28216|Betaproteobacteria H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate ribB - 3.5.4.25,4.1.99.12 ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 - - - DHBP_synthase,GTP_cyclohydro2 k59_1151702_1 5341.XP_007327213.1 4.14e-08 60.5 COG0417@1|root,KOG0969@2759|Eukaryota,38DSD@33154|Opisthokonta,3NUXQ@4751|Fungi,3UYND@5204|Basidiomycota,227YH@155619|Agaricomycetes,3W6EE@5338|Agaricales 4751|Fungi L DNA polymerase POL3 GO:0000228,GO:0000278,GO:0000731,GO:0000781,GO:0000784,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005657,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006278,GO:0006281,GO:0006284,GO:0006287,GO:0006289,GO:0006297,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007049,GO:0008150,GO:0008152,GO:0008296,GO:0008408,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0018130,GO:0019438,GO:0019439,GO:0022402,GO:0022616,GO:0030894,GO:0031974,GO:0031981,GO:0032991,GO:0032993,GO:0033260,GO:0033554,GO:0033567,GO:0034061,GO:0034641,GO:0034644,GO:0034645,GO:0034654,GO:0034655,GO:0042575,GO:0043137,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043596,GO:0043601,GO:0043625,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044271,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044454,GO:0044464,GO:0044786,GO:0045004,GO:0045005,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0061695,GO:0070013,GO:0070914,GO:0071214,GO:0071478,GO:0071482,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0098687,GO:0104004,GO:0140097,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901575,GO:1901576,GO:1902296,GO:1902319,GO:1902494,GO:1902969,GO:1902983,GO:1903047,GO:1903459,GO:1904161,GO:1990234 2.7.7.7 ko:K02327 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03430,ko03440,ko05166,map00230,map00240,map01100,map03030,map03410,map03420,map03430,map03440,map05166 M00262 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol_B,DNA_pol_B_exo1,zf-C4pol k59_1322204_1 1122212.AULO01000008_gene1513 1.5e-26 107.0 COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,1RPTT@1236|Gammaproteobacteria,1XHEI@135619|Oceanospirillales 135619|Oceanospirillales E Belongs to the binding-protein-dependent transport system permease family - - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_1322204_2 1121033.AUCF01000014_gene1266 1.57e-52 174.0 COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,2TSDS@28211|Alphaproteobacteria,2JPSA@204441|Rhodospirillales 204441|Rhodospirillales E Belongs to the binding-protein-dependent transport system permease family - - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_1024068_1 948106.AWZT01000011_gene2044 4.25e-15 74.3 COG0745@1|root,COG0745@2|Bacteria,1MY5Y@1224|Proteobacteria,2VI0W@28216|Betaproteobacteria,1K3A8@119060|Burkholderiaceae 28216|Betaproteobacteria K response regulator basR_3 - - ko:K02483,ko:K07666,ko:K07774 ko02020,ko02024,map02020,map02024 M00453,M00457 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_895951_1 472759.Nhal_0135 1.21e-42 147.0 COG3271@1|root,COG3271@2|Bacteria,1R9HR@1224|Proteobacteria,1RYUR@1236|Gammaproteobacteria,1WY6H@135613|Chromatiales 135613|Chromatiales S Peptidase C39, bacteriocin processing - - - ko:K06992 - - - - ko00000 - - - Peptidase_C39 k59_1236998_1 1437425.CSEC_2018 3.36e-13 66.2 COG1993@1|root,COG1993@2|Bacteria 2|Bacteria T acr, cog1993 - - - ko:K09137 - - - - ko00000 - - - DUF190 k59_1236998_2 1123392.AQWL01000005_gene3097 1.47e-33 131.0 COG1368@1|root,COG1368@2|Bacteria,1MVCM@1224|Proteobacteria,2VMSK@28216|Betaproteobacteria,1KS3R@119069|Hydrogenophilales 119069|Hydrogenophilales M Sulfatase - - - - - - - - - - - - Sulfatase k59_341877_1 530564.Psta_1854 3.82e-69 224.0 COG0160@1|root,COG0160@2|Bacteria,2IYBU@203682|Planctomycetes 203682|Planctomycetes H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 2.6.1.19 ko:K00823 ko00250,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00410,map00640,map00650,map01100,map01120 M00027 R00908,R01648 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_384424_1 1121106.JQKB01000007_gene953 3.87e-82 259.0 COG2072@1|root,COG2072@2|Bacteria,1MUQH@1224|Proteobacteria,2TRG4@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Flavoprotein involved in K transport - - 1.14.13.160,1.14.13.22 ko:K03379,ko:K21730 ko00930,ko01120,ko01220,map00930,map01120,map01220 - R02231,R06622 RC00662,RC01550 ko00000,ko00001,ko01000 - - - FMO-like,Pyr_redox_2,Pyr_redox_3 k59_768142_1 196367.JNFG01000198_gene2351 2.75e-60 201.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VNZF@28216|Betaproteobacteria,1K34S@119060|Burkholderiaceae 28216|Betaproteobacteria C L-carnitine dehydratase bile acid-inducible protein F caiB - - - - - - - - - - - CoA_transf_3 k59_384433_1 571166.KI421509_gene3293 1.38e-17 85.9 COG0834@1|root,COG0834@2|Bacteria,1MV5D@1224|Proteobacteria,2TTXX@28211|Alphaproteobacteria 28211|Alphaproteobacteria ET ABC-type amino acid transport signal transduction systems periplasmic component domain - - - ko:K02030,ko:K10001 ko02010,ko02020,map02010,map02020 M00230,M00236 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3,3.A.1.3.19,3.A.1.3.4 - - SBP_bac_3 k59_43585_1 1454004.AW11_01622 1.01e-40 158.0 COG2304@1|root,COG3419@1|root,COG2304@2|Bacteria,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,2VHY8@28216|Betaproteobacteria 28216|Betaproteobacteria NU pilus assembly protein tip-associated adhesin pilY1 - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC k59_938717_1 338963.Pcar_3003 3.06e-42 158.0 COG1538@1|root,COG1538@2|Bacteria,1MYXE@1224|Proteobacteria,42TA7@68525|delta/epsilon subdivisions,2WR7T@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Outer membrane efflux protein - - - - - - - - - - - - OEP k59_299582_1 107635.AZUO01000001_gene1522 4.23e-52 172.0 COG0008@1|root,COG0008@2|Bacteria,1MUN7@1224|Proteobacteria,2TR2V@28211|Alphaproteobacteria,36XY5@31993|Methylocystaceae 28211|Alphaproteobacteria J tRNA synthetases class I (E and Q), catalytic domain gluQ - - ko:K01894 - - - - ko00000,ko01000,ko01007,ko03016 - - - tRNA-synt_1c k59_598000_2 1268635.Loa_01599 1.29e-89 276.0 COG0121@1|root,COG0121@2|Bacteria,1QB9D@1224|Proteobacteria,1T6TS@1236|Gammaproteobacteria,1JE8I@118969|Legionellales 118969|Legionellales S Glutamine amidotransferases class-II - - - - - - - - - - - - GATase_4 k59_1024303_1 987059.RBXJA2T_04138 2.45e-124 370.0 COG0318@1|root,COG0318@2|Bacteria,1MUMC@1224|Proteobacteria,2VGZE@28216|Betaproteobacteria,1KIY7@119065|unclassified Burkholderiales 28216|Betaproteobacteria IQ PFAM AMP-dependent synthetase and ligase alkK - 6.2.1.44 ko:K20034 ko00920,map00920 - R10820 RC00004,RC00014 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C k59_1024303_2 1532557.JL37_23315 2.19e-35 135.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2VH0Y@28216|Betaproteobacteria,3T2AW@506|Alcaligenaceae 28216|Betaproteobacteria I Belongs to the enoyl-CoA hydratase isomerase family - - 1.1.1.35,4.2.1.17,5.1.2.3 ko:K01782,ko:K07516 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04743,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_1066916_1 640081.Dsui_3324 1.97e-40 136.0 COG1862@1|root,COG1862@2|Bacteria,1MZT2@1224|Proteobacteria,2VU6T@28216|Betaproteobacteria,2KWNW@206389|Rhodocyclales 206389|Rhodocyclales U preprotein translocase subunit YajC yajC - - ko:K03210 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - YajC k59_1066916_2 358220.C380_23040 9.94e-22 94.4 COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,2VHKD@28216|Betaproteobacteria,4A9UJ@80864|Comamonadaceae 28216|Betaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD-TM1,SecD_SecF,Sec_GG k59_427291_1 1217720.ALOX01000045_gene1301 4.66e-40 152.0 COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,2TS8V@28211|Alphaproteobacteria,2JPVY@204441|Rhodospirillales 204441|Rhodospirillales Q ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1351_1 1123257.AUFV01000012_gene2925 2.96e-61 201.0 2CIBN@1|root,2Z8JT@2|Bacteria,1R902@1224|Proteobacteria,1RXPM@1236|Gammaproteobacteria,1X5H4@135614|Xanthomonadales 135614|Xanthomonadales S Metal dependent phosphohydrolases with conserved 'HD' motif. - - - - - - - - - - - - - k59_725685_1 322710.Avin_20870 5.13e-82 259.0 COG0457@1|root,COG0457@2|Bacteria,1N0A9@1224|Proteobacteria,1RZSZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S COG0457 FOG TPR repeat - - - - - - - - - - - - TPR_16,TPR_2,TPR_7 k59_384562_1 1532557.JL37_24740 2.02e-86 266.0 COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,2VI4X@28216|Betaproteobacteria,3T2U3@506|Alcaligenaceae 28216|Betaproteobacteria H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine coaBC - 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - - DFP,Flavoprotein k59_1279710_1 948106.AWZT01000003_gene5816 1.15e-114 346.0 COG1012@1|root,COG1012@2|Bacteria,1MUHV@1224|Proteobacteria,2VI0N@28216|Betaproteobacteria,1K0AQ@119060|Burkholderiaceae 28216|Betaproteobacteria C methylmalonate-semialdehyde dehydrogenase mmsA - 1.2.1.18,1.2.1.27 ko:K00140 ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200 M00013 R00705,R00706,R00922,R00935 RC00004,RC02723,RC02817 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_853474_1 1122963.AUHB01000007_gene3693 1.01e-102 316.0 COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,2TQPV@28211|Alphaproteobacteria,36XKX@31993|Methylocystaceae 28211|Alphaproteobacteria J Ribosomal protein S1-like RNA-binding domain rpsA - - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 k59_725769_1 1547437.LL06_01360 9.27e-61 192.0 COG0526@1|root,COG0526@2|Bacteria,1RI3N@1224|Proteobacteria,2TSEW@28211|Alphaproteobacteria,43H32@69277|Phyllobacteriaceae 28211|Alphaproteobacteria CO periplasmic protein thiol disulfide cycY - - ko:K02199 - - - - ko00000,ko03110 - - - AhpC-TSA,Redoxin k59_43815_1 1038862.KB893843_gene453 1.02e-65 226.0 COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,3JTQ7@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - AAA_16,DZR,Guanylate_cyc,SAM_1 k59_427392_1 1397284.AYMN01000033_gene1126 1.43e-26 112.0 COG0477@1|root,COG2814@2|Bacteria,1MX1Q@1224|Proteobacteria,1RYQ3@1236|Gammaproteobacteria,3ZZW8@613|Serratia 1236|Gammaproteobacteria EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_43819_1 580332.Slit_1234 7.45e-20 89.0 COG2981@1|root,COG2981@2|Bacteria,1Q181@1224|Proteobacteria,2VN29@28216|Betaproteobacteria 28216|Betaproteobacteria E Etoposide-induced protein 2.4 (EI24) - - - - - - - - - - - - EI24 k59_43819_2 203122.Sde_1109 1.3e-27 118.0 COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,1RMU1@1236|Gammaproteobacteria,464K7@72275|Alteromonadaceae 1236|Gammaproteobacteria L COG1643 HrpA-like helicases hrpA GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0006139,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360 3.6.4.13 ko:K03578 - - - - ko00000,ko01000 - - - DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind k59_938903_1 257313.BP3766 4.39e-64 209.0 COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,2VHZN@28216|Betaproteobacteria,3T1BM@506|Alcaligenaceae 28216|Betaproteobacteria M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine murA - 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R00660 RC00350 ko00000,ko00001,ko01000,ko01011 - - - EPSP_synthase k59_938903_2 999541.bgla_1g03750 3.34e-103 304.0 COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,2VIF9@28216|Betaproteobacteria,1K2AQ@119060|Burkholderiaceae 28216|Betaproteobacteria F Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity hisG - 2.4.2.17 ko:K00765 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002,ko01000 - - - HisG k59_640514_2 1454004.AW11_01518 3.39e-56 178.0 COG2010@1|root,COG2010@2|Bacteria,1MZSK@1224|Proteobacteria,2VT0S@28216|Betaproteobacteria 28216|Betaproteobacteria C Cytochrome C oxidase, cbb3-type, subunit III - - - - - - - - - - - - Cytochrom_C k59_640514_3 1266925.JHVX01000003_gene549 3.63e-15 72.0 COG3019@1|root,COG3019@2|Bacteria,1MZ9V@1224|Proteobacteria,2VSDN@28216|Betaproteobacteria,3734N@32003|Nitrosomonadales 28216|Betaproteobacteria S Protein of unknown function, DUF - - - - - - - - - - - - DUF411 k59_853571_1 375286.mma_3356 3.2e-27 108.0 COG4726@1|root,COG4726@2|Bacteria,1N9CE@1224|Proteobacteria,2VWPP@28216|Betaproteobacteria,47556@75682|Oxalobacteraceae 28216|Betaproteobacteria NU Pilus assembly protein PilX - - - - - - - - - - - - - k59_853571_2 1163617.SCD_n02125 4.47e-10 63.2 COG4966@1|root,COG4966@2|Bacteria,1RH2G@1224|Proteobacteria,2VT5C@28216|Betaproteobacteria 28216|Betaproteobacteria NU Type IV Pilus-assembly protein W - - - ko:K02672 - - - - ko00000,ko02035,ko02044 - - - N_methyl,PilW k59_86496_1 1123229.AUBC01000010_gene3435 5.81e-13 73.6 COG0628@1|root,COG0628@2|Bacteria,1MXXU@1224|Proteobacteria,2TVPN@28211|Alphaproteobacteria,3JZU1@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S AI-2E family transporter - - - - - - - - - - - - AI-2E_transport k59_1237328_1 312153.Pnuc_1061 2.71e-27 107.0 COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,2VIQ5@28216|Betaproteobacteria,1K0YZ@119060|Burkholderiaceae 28216|Betaproteobacteria H Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate ilvC - 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 - - - IlvC,IlvN k59_1237328_2 1178482.BJB45_00910 2.95e-36 127.0 COG0440@1|root,COG0440@2|Bacteria,1RAGN@1224|Proteobacteria,1S20I@1236|Gammaproteobacteria,1XJ74@135619|Oceanospirillales 135619|Oceanospirillales E acetolactate synthase ilvH - 2.2.1.6 ko:K01653 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - ACT_5,ALS_ss_C k59_938941_1 1278073.MYSTI_04146 7.61e-51 181.0 COG3591@1|root,COG3591@2|Bacteria,1MX71@1224|Proteobacteria 1224|Proteobacteria E Peptidase S46 - - - - - - - - - - - - Peptidase_S46 k59_1279842_1 1238182.C882_1835 1.6e-59 197.0 COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,2TRTP@28211|Alphaproteobacteria,2JQ87@204441|Rhodospirillales 204441|Rhodospirillales O HflC and HflK could encode or regulate a protease hflK - - ko:K04088 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7,HflK_N k59_768435_1 402881.Plav_0945 2.06e-14 74.7 COG0642@1|root,COG2770@1|root,COG2205@2|Bacteria,COG2770@2|Bacteria,1MW8M@1224|Proteobacteria,2TUSJ@28211|Alphaproteobacteria,1JNHH@119043|Rhodobiaceae 28211|Alphaproteobacteria T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain ragB - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_768435_2 1110502.TMO_2650 4.3e-48 160.0 COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria,2TRTZ@28211|Alphaproteobacteria,2JQ2Y@204441|Rhodospirillales 204441|Rhodospirillales T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - ko:K02483 - - - - ko00000,ko02022 - - - Response_reg,Trans_reg_C k59_1024548_1 1208583.COMX_01985 8.53e-15 79.0 COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,2TQWH@28211|Alphaproteobacteria,2JPJE@204441|Rhodospirillales 204441|Rhodospirillales G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate glmM - 5.4.2.10 ko:K03431 ko00520,ko01100,ko01130,map00520,map01100,map01130 - R02060 RC00408 ko00000,ko00001,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_810969_1 1123501.KB902283_gene2372 2.63e-35 135.0 COG0747@1|root,COG0747@2|Bacteria,1R5VB@1224|Proteobacteria,2U0FR@28211|Alphaproteobacteria 28211|Alphaproteobacteria E COG0747 ABC-type dipeptide transport system, periplasmic component - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_555360_1 886293.Sinac_6249 3.56e-40 150.0 COG2433@1|root,COG2433@2|Bacteria,2IYQC@203682|Planctomycetes 203682|Planctomycetes S Transposase IS66 family - - - ko:K07484 - - - - ko00000 - - - DDE_Tnp_IS66,zf-IS66 k59_1109341_1 234267.Acid_4508 1.2e-66 226.0 COG3408@1|root,COG3408@2|Bacteria 2|Bacteria G Glycogen debranching enzyme - - - - - - - - - - - - Glyco_hydro_63 k59_1152141_1 1458275.AZ34_13200 1.31e-51 168.0 COG2119@1|root,COG2119@2|Bacteria,1RDDV@1224|Proteobacteria,2VQ6X@28216|Betaproteobacteria,4A9XN@80864|Comamonadaceae 28216|Betaproteobacteria S Uncharacterized protein family UPF0016 - - - - - - - - - - - - UPF0016 k59_1152141_2 159087.Daro_1216 6.52e-64 197.0 COG0360@1|root,COG0360@2|Bacteria,1RH82@1224|Proteobacteria,2VR79@28216|Betaproteobacteria,2KWGN@206389|Rhodocyclales 206389|Rhodocyclales J Binds together with S18 to 16S ribosomal RNA rpsF - - ko:K02990 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S6 k59_853650_2 1000565.METUNv1_02832 1.85e-40 146.0 COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,2VI55@28216|Betaproteobacteria,2KV17@206389|Rhodocyclales 206389|Rhodocyclales S Circularly permuted ATP-grasp type 2 - - - - - - - - - - - - CP_ATPgrasp_2 k59_598372_1 187272.Mlg_1944 1e-29 117.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria,1WW27@135613|Chromatiales 135613|Chromatiales J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_598372_2 1265502.KB905936_gene2669 1.56e-28 104.0 COG0184@1|root,COG0184@2|Bacteria,1MZ2W@1224|Proteobacteria,2VU1D@28216|Betaproteobacteria,4AEI9@80864|Comamonadaceae 28216|Betaproteobacteria J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome rpsO - - ko:K02956 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S15 k59_299981_1 278957.ABEA03000201_gene4325 1.24e-22 100.0 COG0444@1|root,COG4608@1|root,COG0444@2|Bacteria,COG4608@2|Bacteria,46U8E@74201|Verrucomicrobia,3KA26@414999|Opitutae 414999|Opitutae P Oligopeptide/dipeptide transporter, C-terminal region - - - ko:K10823 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - ABC_tran,oligo_HPY k59_299981_2 311424.DhcVS_930 3.91e-25 101.0 COG1173@1|root,COG1173@2|Bacteria,2G9WH@200795|Chloroflexi,34DKE@301297|Dehalococcoidia 301297|Dehalococcoidia EP N-terminal TM domain of oligopeptide transport permease C - - - ko:K15582 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - BPD_transp_1,OppC_N k59_768535_1 1110502.TMO_1599 1.4e-10 61.2 28NA5@1|root,2ZBDZ@2|Bacteria,1MXY5@1224|Proteobacteria,2TYZX@28211|Alphaproteobacteria,2JWJ4@204441|Rhodospirillales 204441|Rhodospirillales - - - - - - - - - - - - - - - k59_768535_2 1380394.JADL01000011_gene4003 9.52e-14 71.6 2E1AA@1|root,32WQB@2|Bacteria,1N6IG@1224|Proteobacteria,2UDF7@28211|Alphaproteobacteria,2JU5V@204441|Rhodospirillales 204441|Rhodospirillales - - - - - - - - - - - - - - - k59_43961_1 438753.AZC_3588 1.65e-64 217.0 28MSK@1|root,2ZB0X@2|Bacteria,1R7CY@1224|Proteobacteria,2U2MY@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Bacteriophage head to tail connecting protein - - - - - - - - - - - - Head-tail_con k59_1109398_1 1127696.HMPREF9134_00959 9.84e-34 126.0 COG1013@1|root,COG1013@2|Bacteria,4NIE0@976|Bacteroidetes,2FME7@200643|Bacteroidia,22VVU@171551|Porphyromonadaceae 976|Bacteroidetes C ferredoxin oxidoreductase subunit beta oorB - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C k59_598442_2 243233.MCA1339 1.54e-31 115.0 COG0789@1|root,COG0789@2|Bacteria,1MZ3P@1224|Proteobacteria,1S459@1236|Gammaproteobacteria,1XFIP@135618|Methylococcales 135618|Methylococcales K MerR, DNA binding - - - ko:K08365 - - - - ko00000,ko03000 - - - MerR,MerR-DNA-bind,MerR_1 k59_1758_1 987059.RBXJA2T_08530 2.95e-71 224.0 COG1559@1|root,COG1559@2|Bacteria,1MUQF@1224|Proteobacteria,2VHD4@28216|Betaproteobacteria,1KJYW@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation mltG - - ko:K07082 - - - - ko00000 - - - YceG k59_939130_1 62928.azo1493 1.49e-150 447.0 COG0501@1|root,COG0501@2|Bacteria,1NA37@1224|Proteobacteria,2VIMA@28216|Betaproteobacteria,2KWM3@206389|Rhodocyclales 206389|Rhodocyclales O Peptidase family M48 - - - - - - - - - - - - Peptidase_M48 k59_939130_2 714943.Mucpa_3743 1.19e-92 278.0 COG3510@1|root,COG3510@2|Bacteria,4NMP8@976|Bacteroidetes,1IUHH@117747|Sphingobacteriia 976|Bacteroidetes V cephalosporin hydroxylase - - - - - - - - - - - - CmcI,Methyltransf_24 k59_640709_1 1316932.MHH_c17950 2.58e-15 82.4 COG3566@1|root,COG3566@2|Bacteria,1QWCX@1224|Proteobacteria,1RZS8@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - DUF2213 k59_179726_1 1286106.MPL1_12261 5e-121 352.0 COG0189@1|root,COG0189@2|Bacteria,1MX62@1224|Proteobacteria,1RM8B@1236|Gammaproteobacteria,4609Y@72273|Thiotrichales 72273|Thiotrichales HJ Belongs to the RimK family rimK - - ko:K05844 - - - - ko00000,ko01000,ko03009 - - - RimK k59_1076963_1 1429916.X566_04710 8.01e-28 103.0 2C80N@1|root,33MF2@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_1076963_2 1217656.F964_02927 5.92e-12 64.7 COG0590@1|root,COG0590@2|Bacteria,1RGU0@1224|Proteobacteria,1S60Z@1236|Gammaproteobacteria,3NN6N@468|Moraxellaceae 1236|Gammaproteobacteria FJ Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) tadA GO:0002097,GO:0002100,GO:0003674,GO:0003824,GO:0004000,GO:0005488,GO:0006139,GO:0006382,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008251,GO:0008270,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016553,GO:0016787,GO:0016810,GO:0016814,GO:0019239,GO:0034470,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0046914,GO:0052717,GO:0071704,GO:0090304,GO:1901360 3.5.4.33 ko:K11991 - - R10223 RC00477 ko00000,ko01000,ko03016 - - - MafB19-deam,dCMP_cyt_deam_1 k59_1245399_1 1054213.HMPREF9946_00394 4.87e-23 97.8 COG4948@1|root,COG4948@2|Bacteria,1MW5B@1224|Proteobacteria,2UNXP@28211|Alphaproteobacteria,2JQXX@204441|Rhodospirillales 204441|Rhodospirillales M Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - - - - - - - - - - MR_MLE_C,MR_MLE_N k59_1245399_3 743720.Psefu_3509 1.02e-103 312.0 COG3618@1|root,COG3618@2|Bacteria,1MVG0@1224|Proteobacteria,1RNCH@1236|Gammaproteobacteria 1236|Gammaproteobacteria S metal-dependent hydrolase of the TIM-barrel fold - - - - - - - - - - - - Amidohydro_2 k59_1245399_4 1380394.JADL01000012_gene827 1.56e-69 224.0 COG2084@1|root,COG2084@2|Bacteria,1NS71@1224|Proteobacteria,2U0T6@28211|Alphaproteobacteria,2JW5G@204441|Rhodospirillales 204441|Rhodospirillales I NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - - - - - - - - - - - NAD_binding_11,NAD_binding_2 k59_860577_1 153948.NAL212_2994 6.64e-33 129.0 COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,2VHUF@28216|Betaproteobacteria,37271@32003|Nitrosomonadales 28216|Betaproteobacteria L DNA topoisomerase, type IA, central topB - 5.99.1.2 ko:K03169 - - - - ko00000,ko01000,ko03032 - - - SWIB,Topoisom_bac,Toprim,Toprim_Crpt k59_946913_1 795666.MW7_1274 1.14e-130 394.0 COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,2VJYV@28216|Betaproteobacteria,1JZXQ@119060|Burkholderiaceae 28216|Betaproteobacteria C NADH-quinone oxidoreductase nuoG - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_946913_2 257313.BP0846 7.54e-91 279.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,2VJJ1@28216|Betaproteobacteria,3T384@506|Alcaligenaceae 28216|Betaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain nuoF - 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_51K,NADH_4Fe-4S,SLBB k59_989580_1 1469245.JFBG01000097_gene1350 4.89e-70 224.0 COG0683@1|root,COG0683@2|Bacteria,1MWQB@1224|Proteobacteria 1224|Proteobacteria E COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_1034487_1 1266925.JHVX01000008_gene272 8.67e-25 103.0 COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,2VKV7@28216|Betaproteobacteria,3723Y@32003|Nitrosomonadales 28216|Betaproteobacteria C TIGRFAM Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6 ubiH - - ko:K03185 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04989,R08773 RC02670 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_3 k59_392503_1 640081.Dsui_2204 2.29e-146 436.0 COG4166@1|root,COG4166@2|Bacteria,1R87R@1224|Proteobacteria,2VKFJ@28216|Betaproteobacteria,2KU6I@206389|Rhodocyclales 206389|Rhodocyclales E extracellular solute-binding protein oppA - - - - - - - - - - - SBP_bac_5 k59_1116250_1 1123393.KB891327_gene489 8.07e-81 251.0 COG0624@1|root,COG0624@2|Bacteria,1MW6G@1224|Proteobacteria,2VHRF@28216|Betaproteobacteria,1KRB8@119069|Hydrogenophilales 119069|Hydrogenophilales E Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls dapE - 3.5.1.18 ko:K01439 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R02734 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20 k59_904362_1 1121035.AUCH01000009_gene839 3.24e-106 318.0 COG3178@1|root,COG3178@2|Bacteria,1MXCH@1224|Proteobacteria,2VHBC@28216|Betaproteobacteria,2KUFJ@206389|Rhodocyclales 206389|Rhodocyclales S phosphotransferase related to Ser Thr protein kinases - - 2.7.1.221 ko:K07102 ko00520,ko01100,map00520,map01100 - R08968,R11024 RC00002,RC00078 ko00000,ko00001,ko01000 - - - APH k59_93559_1 1033730.CAHG01000007_gene2569 5.19e-22 97.4 COG0631@1|root,COG0631@2|Bacteria,2GJ3M@201174|Actinobacteria,4DNAN@85009|Propionibacteriales 201174|Actinobacteria T Serine/threonine phosphatases, family 2C, catalytic domain pstP GO:0000287,GO:0001932,GO:0001933,GO:0003674,GO:0003824,GO:0004647,GO:0004721,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006469,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009892,GO:0009987,GO:0010563,GO:0010605,GO:0016020,GO:0016021,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019220,GO:0019222,GO:0019538,GO:0030145,GO:0030312,GO:0031224,GO:0031226,GO:0031323,GO:0031324,GO:0031399,GO:0031400,GO:0032268,GO:0032269,GO:0033673,GO:0036211,GO:0042325,GO:0042326,GO:0042578,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043392,GO:0043412,GO:0043549,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0045859,GO:0045936,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051098,GO:0051100,GO:0051101,GO:0051171,GO:0051172,GO:0051174,GO:0051246,GO:0051248,GO:0051338,GO:0051348,GO:0060255,GO:0065007,GO:0065009,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C,PP2C_2 k59_860610_1 1123393.KB891330_gene766 4.98e-20 88.6 COG1999@1|root,COG1999@2|Bacteria,1RHK3@1224|Proteobacteria,2VRBY@28216|Betaproteobacteria,1KSKQ@119069|Hydrogenophilales 119069|Hydrogenophilales S signal sequence binding - - - - - - - - - - - - - k59_860610_2 335283.Neut_2391 3.34e-07 52.4 COG3346@1|root,COG3346@2|Bacteria,1MZUH@1224|Proteobacteria,2VSAZ@28216|Betaproteobacteria,372Z1@32003|Nitrosomonadales 28216|Betaproteobacteria S SURF1-like protein surf1 - - ko:K14998 - - - - ko00000,ko03029 3.D.4.8 - - SURF1 k59_778078_1 1458357.BG58_31870 1.07e-19 85.9 COG2146@1|root,COG2146@2|Bacteria,1N72F@1224|Proteobacteria,2VUWS@28216|Betaproteobacteria,1K8WU@119060|Burkholderiaceae 28216|Betaproteobacteria P PFAM Rieske 2Fe-2S - - - - - - - - - - - - Rieske k59_778078_2 1298867.AUES01000006_gene361 0.000134 43.9 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TR15@28211|Alphaproteobacteria,3JV3V@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1332200_1 502025.Hoch_4714 2.04e-10 60.8 COG1651@1|root,COG1651@2|Bacteria,1MX2T@1224|Proteobacteria,43A6F@68525|delta/epsilon subdivisions,2XA3X@28221|Deltaproteobacteria,2Z18A@29|Myxococcales 28221|Deltaproteobacteria O PFAM DSBA oxidoreductase - - - - - - - - - - - - DSBA,Thioredoxin_4 k59_1245455_1 266779.Meso_4559 2.41e-20 93.6 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria,43IYW@69277|Phyllobacteriaceae 28211|Alphaproteobacteria C aldehyde oxidase and xanthine dehydrogenase, a b hammerhead - - - - - - - - - - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_1245455_2 1123368.AUIS01000018_gene728 1.95e-33 121.0 COG0589@1|root,COG0589@2|Bacteria,1N9BR@1224|Proteobacteria,1SFNQ@1236|Gammaproteobacteria,2NDEZ@225057|Acidithiobacillales 225057|Acidithiobacillales T Belongs to the universal stress protein A family - - - - - - - - - - - - Usp k59_520825_1 1238182.C882_3652 4.9e-70 230.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TSB1@28211|Alphaproteobacteria,2JQBQ@204441|Rhodospirillales 204441|Rhodospirillales EH Belongs to the TPP enzyme family - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_478136_2 1038866.KB902824_gene1215 6.81e-50 166.0 COG1028@1|root,COG1028@2|Bacteria,1MVYJ@1224|Proteobacteria,2TTUU@28211|Alphaproteobacteria,3JUWX@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria IQ Enoyl-(Acyl carrier protein) reductase - - 1.1.1.69 ko:K00046 - - - - ko00000,ko01000 - - - adh_short_C2 k59_520844_1 488538.SAR116_1471 1.63e-77 241.0 COG0715@1|root,COG0715@2|Bacteria 2|Bacteria P thiamine-containing compound biosynthetic process - - - ko:K02051 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - NMT1,NMT1_2 k59_691332_2 264462.Bd0660 3.47e-56 187.0 2BI6Q@1|root,32CBY@2|Bacteria,1MYDT@1224|Proteobacteria,42T3X@68525|delta/epsilon subdivisions,2MTZ4@213481|Bdellovibrionales,2WPSM@28221|Deltaproteobacteria 213481|Bdellovibrionales S Protein of unknown function (DUF2914) - - - - - - - - - - - - DUF2914 k59_817983_1 1521187.JPIM01000040_gene509 7.27e-32 125.0 COG0437@1|root,COG0437@2|Bacteria,2G82U@200795|Chloroflexi 200795|Chloroflexi C 4Fe-4S dicluster domain - - - ko:K00184 - - - - ko00000 5.A.3 - - Fer4_11 k59_1202915_1 1146883.BLASA_2557 1.09e-39 145.0 COG1024@1|root,COG1024@2|Bacteria,2GMNR@201174|Actinobacteria,4EU2N@85013|Frankiales 201174|Actinobacteria I Enoyl-CoA hydratase/isomerase boxC - 4.1.2.44 ko:K15513 ko00362,map00362 - R09556 RC03426 ko00000,ko00001,ko01000 - - - ECH_1 k59_1202915_2 76114.ebA2762 6.38e-38 137.0 COG0703@1|root,COG1476@1|root,COG0703@2|Bacteria,COG1476@2|Bacteria,1MX66@1224|Proteobacteria,2VK91@28216|Betaproteobacteria,2KYAV@206389|Rhodocyclales 206389|Rhodocyclales F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate boxR - - ko:K15546 - - - - ko00000,ko03000 - - - HTH_31,SKI k59_53837_1 224911.27355835 1.34e-55 179.0 2E3HM@1|root,32YG7@2|Bacteria,1RFJA@1224|Proteobacteria,2U8PF@28211|Alphaproteobacteria,3JYXJ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_136170_1 977880.RALTA_A1867 8.42e-83 257.0 COG1485@1|root,COG1485@2|Bacteria,1MUUW@1224|Proteobacteria,2VHQX@28216|Betaproteobacteria,1K0KZ@119060|Burkholderiaceae 28216|Betaproteobacteria S PFAM AFG1-family ATPase yhcM - - ko:K06916 - - - - ko00000,ko03036 - - - AFG1_ATPase k59_520947_1 1366055.S5M9Y8_9CAUD 1.12e-32 134.0 4R0F1@35237|dsDNA viruses no RNA stage,4QKRS@10699|Siphoviridae 10699|Siphoviridae S Putative phage tail protein - GO:0005575,GO:0008150,GO:0016032,GO:0018995,GO:0019012,GO:0019058,GO:0019062,GO:0022610,GO:0030430,GO:0033643,GO:0033646,GO:0043656,GO:0043657,GO:0044215,GO:0044216,GO:0044217,GO:0044403,GO:0044406,GO:0044419,GO:0044650,GO:0051704 - - - - - - - - - - - k59_904522_1 1502850.FG91_02594 3.45e-14 72.8 COG1252@1|root,COG1252@2|Bacteria,1QUKT@1224|Proteobacteria,2TW32@28211|Alphaproteobacteria,2K9BR@204457|Sphingomonadales 204457|Sphingomonadales C Pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Pyr_redox_2 k59_904522_2 983917.RGE_18530 4.14e-45 160.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VJ5E@28216|Betaproteobacteria,1KJPF@119065|unclassified Burkholderiales 28216|Betaproteobacteria I AMP-binding enzyme C-terminal domain bclA_2 - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_435746_1 265072.Mfla_2290 6.4e-99 298.0 COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,2VJ2E@28216|Betaproteobacteria,2KM7K@206350|Nitrosomonadales 206350|Nitrosomonadales K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template rho - - ko:K03628 ko03018,map03018 - - - ko00000,ko00001,ko03019,ko03021 - - - ATP-synt_ab,Rho_N,Rho_RNA_bind k59_562555_1 1218075.BAYA01000026_gene5525 1.2e-22 97.4 COG1057@1|root,COG1057@2|Bacteria,1RD0J@1224|Proteobacteria,2VSQ7@28216|Betaproteobacteria,1K1HI@119060|Burkholderiaceae 28216|Betaproteobacteria H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) nadD - 2.7.7.18 ko:K00969 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_562555_2 420662.Mpe_A3400 2.79e-47 165.0 COG0477@1|root,COG2814@2|Bacteria,1MV79@1224|Proteobacteria,2VMJE@28216|Betaproteobacteria,1KKQM@119065|unclassified Burkholderiales 28216|Betaproteobacteria EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_904544_1 331869.BAL199_00400 1.79e-191 536.0 COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,1MZ45@1224|Proteobacteria,2TTG7@28211|Alphaproteobacteria,4BT5R@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria L Integrase core domain - - - - - - - - - - - - HTH_29,rve,rve_3 k59_818052_1 522306.CAP2UW1_1755 6.96e-54 184.0 COG1566@1|root,COG1566@2|Bacteria,1MU7I@1224|Proteobacteria,2VHA2@28216|Betaproteobacteria 28216|Betaproteobacteria V PFAM secretion protein HlyD family protein - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_264242_2 864051.BurJ1DRAFT_1460 8.65e-96 290.0 COG0382@1|root,COG0382@2|Bacteria,1RFNQ@1224|Proteobacteria,2W5W3@28216|Betaproteobacteria 28216|Betaproteobacteria H UbiA prenyltransferase family - - - - - - - - - - - - UbiA k59_1160354_1 1522072.IL54_0071 2.79e-86 261.0 COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,2TRGY@28211|Alphaproteobacteria,2K0MX@204457|Sphingomonadales 204457|Sphingomonadales L Bacterial dnaA protein - - - - - - - - - - - - IstB_IS21 k59_1034803_1 391626.OAN307_c10220 2.82e-05 51.2 COG0845@1|root,COG0845@2|Bacteria,1R4JA@1224|Proteobacteria,2U49T@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_1287860_1 880073.Calab_0218 1.04e-57 192.0 COG0183@1|root,COG0183@2|Bacteria,2NNU9@2323|unclassified Bacteria 2|Bacteria I Belongs to the thiolase family atoB - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - iJN746.PP_2215 Thiolase_C,Thiolase_N k59_521051_1 1000565.METUNv1_03673 4.29e-42 155.0 COG2831@1|root,COG2831@2|Bacteria,1MWEC@1224|Proteobacteria,2VJXF@28216|Betaproteobacteria,2KX5Q@206389|Rhodocyclales 28216|Betaproteobacteria U Haemolysin secretion/activation protein ShlB/FhaC/HecB - - - - - - - - - - - - POTRA_2,ShlB k59_264287_1 1120956.JHZK01000029_gene76 6.13e-18 80.5 COG0817@1|root,COG0817@2|Bacteria,1MUJI@1224|Proteobacteria,2U70Z@28211|Alphaproteobacteria,1JNYA@119043|Rhodobiaceae 28211|Alphaproteobacteria L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group ruvC GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576 3.1.22.4 ko:K01159 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvC k59_264287_2 1430440.MGMSRv2_0776 4.57e-52 171.0 COG0632@1|root,COG0632@2|Bacteria,1MWJR@1224|Proteobacteria,2TSKM@28211|Alphaproteobacteria,2JSAH@204441|Rhodospirillales 204441|Rhodospirillales L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB ruvA - 3.6.4.12 ko:K03550 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - HHH_5,RuvA_C,RuvA_N k59_11350_1 977880.RALTA_A1941 4.85e-90 275.0 COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,2VJ2E@28216|Betaproteobacteria,1JZZX@119060|Burkholderiaceae 28216|Betaproteobacteria K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template rho - - ko:K03628 ko03018,map03018 - - - ko00000,ko00001,ko03019,ko03021 - - - ATP-synt_ab,Rho_N,Rho_RNA_bind k59_691549_1 1132855.KB913035_gene1444 5.44e-34 129.0 COG5316@1|root,COG5316@2|Bacteria,1QCVP@1224|Proteobacteria,2VNEJ@28216|Betaproteobacteria,2KKQV@206350|Nitrosomonadales 206350|Nitrosomonadales S Domain of unknown function (DUF4139) - - - - - - - - - - - - DUF4139 k59_1203046_1 1279019.ARQK01000060_gene2295 6.32e-83 254.0 COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,1RMC5@1236|Gammaproteobacteria,1WWXT@135613|Chromatiales 135613|Chromatiales V PFAM ABC transporter - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1203047_1 203122.Sde_2346 1.04e-77 246.0 COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,1RMF9@1236|Gammaproteobacteria,464W8@72275|Alteromonadaceae 1236|Gammaproteobacteria L COG3547 Transposase and inactivated derivatives - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_1160428_1 391626.OAN307_c22380 9.85e-89 271.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TSGZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase (IS116 IS110 IS902 family) - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_1203084_1 1122134.KB893650_gene102 1.18e-17 78.2 COG0858@1|root,COG0858@2|Bacteria,1MZPE@1224|Proteobacteria,1S9AF@1236|Gammaproteobacteria,1XKKG@135619|Oceanospirillales 135619|Oceanospirillales J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA rbfA - - ko:K02834 - - - - ko00000,ko03009 - - - RBFA k59_1203084_2 426114.THI_1615 1.58e-44 160.0 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,2VK2H@28216|Betaproteobacteria,1KJJS@119065|unclassified Burkholderiales 28216|Betaproteobacteria J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,IF-2,IF2_N,IF2_assoc k59_778455_1 1535422.ND16A_1814 1.84e-76 255.0 COG2132@1|root,COG2132@2|Bacteria,1PM6Q@1224|Proteobacteria,1RRZJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Parallel beta-helix repeats - - - - - - - - - - - - Cu-oxidase_3 k59_1160481_1 935567.JAES01000003_gene231 1.91e-34 124.0 COG0625@1|root,COG0625@2|Bacteria,1REDI@1224|Proteobacteria,1S13N@1236|Gammaproteobacteria,1X4XE@135614|Xanthomonadales 135614|Xanthomonadales O Belongs to the GST superfamily gst5 - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_N,GST_N_3 k59_1160481_2 1095769.CAHF01000022_gene183 1.66e-31 122.0 COG0847@1|root,COG0847@2|Bacteria,1MV8Z@1224|Proteobacteria,2VK3W@28216|Betaproteobacteria,4795W@75682|Oxalobacteraceae 28216|Betaproteobacteria L EXOIII - - 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - GIY-YIG,RNase_T k59_1077447_1 997346.HMPREF9374_0401 1.35e-20 92.8 COG3328@1|root,COG3328@2|Bacteria,1W73S@1239|Firmicutes,4HXXN@91061|Bacilli,27D8K@186824|Thermoactinomycetaceae 91061|Bacilli L MULE transposase domain - - - - - - - - - - - - Transposase_mut k59_264368_1 1510531.JQJJ01000010_gene1996 1.45e-65 224.0 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria,3JQVN@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain MA20_27485 - 1.2.5.3 ko:K03520 - - R11168 RC02800 ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_54087_1 1101195.Meth11DRAFT_1615 1.48e-105 327.0 COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,2VHJV@28216|Betaproteobacteria,2KKKE@206350|Nitrosomonadales 206350|Nitrosomonadales D Ftsk_gamma - - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma k59_1034989_1 626887.J057_20310 3e-45 162.0 COG2114@1|root,COG2114@2|Bacteria,1MV1V@1224|Proteobacteria,1RYBQ@1236|Gammaproteobacteria,464T6@72275|Alteromonadaceae 1236|Gammaproteobacteria T COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain) cyaB - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_cyc,MASE2 k59_1082479_1 1502770.JQMG01000001_gene2056 1.28e-50 163.0 COG0780@1|root,COG0780@2|Bacteria,1MW0M@1224|Proteobacteria,2VINU@28216|Betaproteobacteria,2KMK5@206350|Nitrosomonadales 206350|Nitrosomonadales S Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) queF - 1.7.1.13 ko:K09457 ko00790,ko01100,map00790,map01100 - R07605 RC01875 ko00000,ko00001,ko01000,ko03016 - - - QueF k59_1082479_2 267608.RSc1394 1.41e-171 491.0 COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,2VIEP@28216|Betaproteobacteria,1K0HW@119060|Burkholderiaceae 28216|Betaproteobacteria E PFAM aminotransferase class I and II dapC - 2.6.1.17 ko:K14267 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R04475 RC00006 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_525220_1 1126627.BAWE01000005_gene6111 1.03e-86 290.0 COG1572@1|root,COG2931@1|root,COG3210@1|root,COG4070@1|root,COG1572@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4070@2|Bacteria,1MU7T@1224|Proteobacteria 1224|Proteobacteria Q COG2931, RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - Autotransporter,Cadherin-like,Calx-beta,DUF4347,He_PIG k59_951336_1 388739.RSK20926_17552 1.43e-32 133.0 COG0591@1|root,COG0642@1|root,COG0591@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,2TR1M@28211|Alphaproteobacteria,2P13X@2433|Roseobacter 28211|Alphaproteobacteria T Histidine kinase resE - - - - - - - - - - - HATPase_c,HisKA,PAS_7,Response_reg,SSF k59_59128_1 472759.Nhal_1233 3.83e-91 272.0 COG0491@1|root,COG0491@2|Bacteria,1MU8Q@1224|Proteobacteria,1S22I@1236|Gammaproteobacteria,1WWHZ@135613|Chromatiales 135613|Chromatiales S Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid gloB - 3.1.2.6 ko:K01069 ko00620,map00620 - R01736 RC00004,RC00137 ko00000,ko00001,ko01000 - - - HAGH_C,Lactamase_B k59_1040140_1 1121930.AQXG01000003_gene2586 2.15e-70 225.0 COG0282@1|root,COG0282@2|Bacteria,4NFI0@976|Bacteroidetes,1IPB9@117747|Sphingobacteriia 976|Bacteroidetes C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction ackA - 2.7.2.1 ko:K00925 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00315,R01353 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - Acetate_kinase k59_1082554_2 1458275.AZ34_01280 1.25e-152 437.0 COG1960@1|root,COG1960@2|Bacteria,1MUK0@1224|Proteobacteria,2VHDV@28216|Betaproteobacteria,4AA6Z@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM acyl-CoA dehydrogenase domain protein gcdH - 1.3.8.6 ko:K00252 ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130 M00032 R02487,R02488,R10074 RC00052,RC00156 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_439998_1 1123255.JHYS01000008_gene3069 2.38e-74 232.0 COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,2VK14@28216|Betaproteobacteria,4ACCJ@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM Patatin - - - ko:K07001 - - - - ko00000 - - - Patatin k59_440005_1 269797.Mbar_A0771 2.47e-99 297.0 COG1064@1|root,arCOG01455@2157|Archaea,2XVSS@28890|Euryarchaeota 28890|Euryarchaeota C COG1064 Zn-dependent alcohol dehydrogenases - - 1.1.1.1,1.1.1.2 ko:K00002,ko:K13953 ko00010,ko00040,ko00071,ko00350,ko00561,ko00625,ko00626,ko00830,ko00930,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00040,map00071,map00350,map00561,map00625,map00626,map00830,map00930,map00980,map00982,map01100,map01110,map01120,map01130,map01220 M00014 R00623,R00746,R00754,R01041,R01481,R02124,R04880,R05231,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00108,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ADH_N,ADH_zinc_N k59_268018_1 1298867.AUES01000048_gene4585 4.15e-21 84.7 COG2984@1|root,COG2984@2|Bacteria 2|Bacteria S ABC transporter substrate binding protein - - - ko:K01989 - M00247 - - ko00000,ko00002,ko02000 - - - ABC_sub_bind k59_268018_2 1037409.BJ6T_87360 2.23e-27 110.0 COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S ABC transporter substrate binding protein - - - ko:K01989 - M00247 - - ko00000,ko00002,ko02000 - - - ABC_sub_bind k59_525311_1 1288826.MSNKSG1_11873 5.93e-96 293.0 COG2041@1|root,COG2041@2|Bacteria,1MX9E@1224|Proteobacteria,1RP2M@1236|Gammaproteobacteria,465VE@72275|Alteromonadaceae 1236|Gammaproteobacteria S Mo-co oxidoreductase dimerisation domain - - - - - - - - - - - - Cytochrome_CBB3,Mo-co_dimer,Oxidored_molyb k59_97568_1 1268622.AVS7_03598 8.81e-85 268.0 COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,2VH2H@28216|Betaproteobacteria,4ABB4@80864|Comamonadaceae 28216|Betaproteobacteria M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein murF - 6.3.2.10,6.3.2.13 ko:K01929,ko:K15792 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 - R02788,R04573,R04617 RC00064,RC00090,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_1207342_1 85643.Tmz1t_1385 5.39e-96 286.0 COG0714@1|root,COG0714@2|Bacteria,1MV5I@1224|Proteobacteria,2VH9H@28216|Betaproteobacteria,2KVTW@206389|Rhodocyclales 206389|Rhodocyclales O ATPase (AAA - - - - - - - - - - - - AAA,AAA_5 k59_864554_1 266834.SMc04131 9.72e-68 222.0 COG4948@1|root,COG4948@2|Bacteria,1MV2S@1224|Proteobacteria,2TTFB@28211|Alphaproteobacteria,4BA6Q@82115|Rhizobiaceae 28211|Alphaproteobacteria M Mandelate Racemase Muconate Lactonizing - - - - - - - - - - - - MR_MLE_C k59_482654_1 1123487.KB892834_gene2980 7.64e-65 216.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2VHAN@28216|Betaproteobacteria,2KUI4@206389|Rhodocyclales 206389|Rhodocyclales P COG1132 ABC-type multidrug transport system, ATPase and permease components - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_482658_1 267608.RSc2844 3.27e-63 205.0 COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,2VH32@28216|Betaproteobacteria,1JZPA@119060|Burkholderiaceae 28216|Betaproteobacteria M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) murG - 2.4.1.227 ko:K02563 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 - R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011 - GT28 - Glyco_tran_28_C,Glyco_transf_28 k59_908965_1 394.NGR_c19360 8.38e-18 88.6 COG0457@1|root,COG3629@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2UJ4X@28211|Alphaproteobacteria,4BF56@82115|Rhizobiaceae 28211|Alphaproteobacteria T Bacterial transcriptional activator domain - - - - - - - - - - - - BTAD,TPR_16,TPR_8 k59_226640_1 396588.Tgr7_2005 1.24e-57 191.0 COG0686@1|root,COG0686@2|Bacteria,1QTX1@1224|Proteobacteria,1T1JB@1236|Gammaproteobacteria,1WXVZ@135613|Chromatiales 135613|Chromatiales C Belongs to the AlaDH PNT family - - 1.4.1.1 ko:K00259 ko00250,ko00430,ko01100,map00250,map00430,map01100 - R00396 RC00008 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N k59_908966_1 401053.AciPR4_0485 1.19e-08 61.2 2E93F@1|root,333CD@2|Bacteria,3Y9CR@57723|Acidobacteria,2JP6M@204432|Acidobacteriia 204432|Acidobacteriia - - - - - - - - - - - - - - - k59_1082639_1 631362.Thi970DRAFT_04215 1.24e-68 214.0 COG3751@1|root,COG3751@2|Bacteria,1RBXB@1224|Proteobacteria,1RR8W@1236|Gammaproteobacteria,1WWUG@135613|Chromatiales 135613|Chromatiales O 2OG-Fe(II) oxygenase superfamily - - - - - - - - - - - - 2OG-FeII_Oxy_3 k59_1082639_2 768671.ThimaDRAFT_3392 4.61e-20 85.9 28QMK@1|root,2ZD39@2|Bacteria,1RAWM@1224|Proteobacteria,1S2FU@1236|Gammaproteobacteria,1WY0Y@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_960059_2 1458275.AZ34_11055 1.39e-20 90.5 COG0028@1|root,COG0028@2|Bacteria,1MXDW@1224|Proteobacteria,2VHRD@28216|Betaproteobacteria,4ABWV@80864|Comamonadaceae 28216|Betaproteobacteria EH Belongs to the TPP enzyme family oxc - 4.1.1.8 ko:K01577 ko00630,ko01100,map00630,map01100 - R01908 RC00620 ko00000,ko00001,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1050610_1 977880.RALTA_B1541 2.33e-47 171.0 COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2VI6F@28216|Betaproteobacteria,1K0X6@119060|Burkholderiaceae 28216|Betaproteobacteria E Belongs to the GMC oxidoreductase family - - 1.1.99.1 ko:K00108 ko00260,ko01100,map00260,map01100 M00555 R01025 RC00087 ko00000,ko00001,ko00002,ko01000 - - - GMC_oxred_C,GMC_oxred_N k59_235127_1 1207063.P24_16747 1.87e-93 297.0 COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2TQY9@28211|Alphaproteobacteria,2JQJ8@204441|Rhodospirillales 204441|Rhodospirillales S transport system, fused permease components - - - - - - - - - - - - DUF3394,DctM k59_1050616_1 1238190.AMQY01000011_gene1945 1.83e-56 198.0 COG0591@1|root,COG0784@1|root,COG2202@1|root,COG3829@1|root,COG4191@1|root,COG0591@2|Bacteria,COG0784@2|Bacteria,COG2202@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,1QTSW@1224|Proteobacteria,1T1G2@1236|Gammaproteobacteria,1XH3H@135619|Oceanospirillales 135619|Oceanospirillales T COG0591 Na proline symporter - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,PAS_7,Response_reg,SSF k59_704516_1 113395.AXAI01000001_gene2773 1.67e-85 270.0 COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,2TRDD@28211|Alphaproteobacteria,3JSDV@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,Transket_pyr,Transketolase_C k59_275894_1 331869.BAL199_17093 6.35e-86 270.0 COG0008@1|root,COG0008@2|Bacteria,1MUC8@1224|Proteobacteria,2TRKX@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Glutaminyl-tRNA synthetase glnS - 6.1.1.18 ko:K01886 ko00970,ko01100,map00970,map01100 M00359,M00360 R03652 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1c,tRNA-synt_1c_C k59_1050665_1 1410620.SHLA_17c000390 1.05e-82 258.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,4B9AQ@82115|Rhizobiaceae 28211|Alphaproteobacteria C Belongs to the aldehyde dehydrogenase family prr - 1.2.1.19 ko:K00137 ko00330,ko00410,ko01100,map00330,map00410,map01100 - R02549 RC00080 ko00000,ko00001,ko01000 - - - Aldedh k59_147832_2 339670.Bamb_1001 6.19e-105 314.0 COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,2VI6I@28216|Betaproteobacteria,1K0WZ@119060|Burkholderiaceae 28216|Betaproteobacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP fabF GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0016740,GO:0016746,GO:0016747,GO:0033817 2.3.1.179 ko:K00646,ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004,ko01008 - - - Ketoacyl-synt_C,ketoacyl-synt k59_1300530_1 522306.CAP2UW1_3392 1.91e-55 187.0 COG1721@1|root,COG1721@2|Bacteria,1MXDI@1224|Proteobacteria,2WFR3@28216|Betaproteobacteria 28216|Betaproteobacteria S Protein of unknown function DUF58 - - - - - - - - - - - - DUF58 k59_1216123_1 1123487.KB892857_gene2370 0.000102 43.5 COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,2VIEV@28216|Betaproteobacteria,2KV3Q@206389|Rhodocyclales 206389|Rhodocyclales K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoN1 - - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD k59_1216123_2 1144319.PMI16_01219 1.62e-38 132.0 COG1544@1|root,COG1544@2|Bacteria,1MZHW@1224|Proteobacteria,2VU5H@28216|Betaproteobacteria,474HZ@75682|Oxalobacteraceae 28216|Betaproteobacteria J Sigma 54 modulation protein / S30EA ribosomal protein raiA - - ko:K05808 - - - - ko00000,ko03009 - - - Ribosomal_S30AE k59_1216123_3 269482.Bcep1808_2898 0.000211 42.7 COG1762@1|root,COG1762@2|Bacteria,1RD0E@1224|Proteobacteria,2VRDH@28216|Betaproteobacteria,1K48R@119060|Burkholderiaceae 28216|Betaproteobacteria G PFAM phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 ptsN - - ko:K02806 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 - - - PTS_EIIA_2 k59_704570_1 990285.RGCCGE502_07344 2.51e-31 127.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,2USBB@28211|Alphaproteobacteria,4B7A5@82115|Rhizobiaceae 28211|Alphaproteobacteria M penicillin-binding protein mrcA - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - PCB_OB,Transgly,Transpeptidase k59_1300554_1 404589.Anae109_3096 1.06e-14 73.2 COG4091@1|root,COG4091@2|Bacteria,1MUZX@1224|Proteobacteria,42NVM@68525|delta/epsilon subdivisions,2WJHT@28221|Deltaproteobacteria 28221|Deltaproteobacteria E homoserine dehydrogenase - - - - - - - - - - - - NAD_binding_3 k59_1300554_2 1123367.C666_01475 3.08e-31 112.0 COG2919@1|root,COG2919@2|Bacteria,1N7AA@1224|Proteobacteria,2VVQJ@28216|Betaproteobacteria 28216|Betaproteobacteria D Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic ftsB - - ko:K05589 - - - - ko00000,ko03036 - - - DivIC k59_1216145_1 59538.XP_005977176.1 7.4e-79 249.0 COG1804@1|root,KOG3957@2759|Eukaryota,38CWZ@33154|Opisthokonta,3BB7M@33208|Metazoa,3D0JC@33213|Bilateria,4838Z@7711|Chordata,48ZTZ@7742|Vertebrata,3JBNC@40674|Mammalia 2759|Eukaryota I succinate-hydroxymethylglutarate CoA-transferase activity - - 2.8.3.13,2.8.3.19,5.1.99.4 ko:K01796,ko:K18702,ko:K18703 ko00120,ko01100,ko04146,map00120,map01100,map04146 M00104 R08734,R08739 RC02345 ko00000,ko00001,ko00002,ko01000 - - - CoA_transf_3 k59_1258824_2 436308.Nmar_0596 9.09e-35 124.0 arCOG05400@1|root,arCOG05400@2157|Archaea,41SQH@651137|Thaumarchaeota 651137|Thaumarchaeota S PFAM Polyketide cyclase dehydrase and lipid transport - - - - - - - - - - - - Polyketide_cyc2 k59_406038_1 1304883.KI912532_gene984 3.73e-43 151.0 COG2391@1|root,COG2391@2|Bacteria,1MXSE@1224|Proteobacteria,2VKGG@28216|Betaproteobacteria,2KVG7@206389|Rhodocyclales 206389|Rhodocyclales S Sulphur transport - - - ko:K07112 - - - - ko00000 - - - Sulf_transp k59_367670_1 1255043.TVNIR_1860 5.92e-69 223.0 COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,1RMXH@1236|Gammaproteobacteria,1WW29@135613|Chromatiales 135613|Chromatiales S PFAM Uncharacterised protein family UPF0027 rtcB - 6.5.1.3 ko:K14415 - - - - ko00000,ko01000,ko03016 - - - RtcB k59_1093114_2 1122603.ATVI01000005_gene3749 3.48e-42 140.0 COG3215@1|root,COG3215@2|Bacteria,1RGWZ@1224|Proteobacteria,1S4YE@1236|Gammaproteobacteria,1X6W7@135614|Xanthomonadales 135614|Xanthomonadales NU Pilus assembly protein PilZ pilZ - - ko:K02676 - - - - ko00000,ko02035,ko02044 - - - PilZ k59_1300619_1 570952.ATVH01000017_gene1758 5.98e-76 234.0 COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,2U5P0@28211|Alphaproteobacteria,2JSBM@204441|Rhodospirillales 204441|Rhodospirillales J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance ctc - - ko:K02897 ko03010,map03010 M00178 - - ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L25p,Ribosomal_TL5_C k59_147917_1 291985.CCSI01000004_gene598 9.99e-85 262.0 COG0673@1|root,COG0673@2|Bacteria,1MXDE@1224|Proteobacteria,2TSGR@28211|Alphaproteobacteria,2K1WD@204457|Sphingomonadales 204457|Sphingomonadales S Oxidoreductase family, C-terminal alpha/beta domain - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_276004_1 1144342.PMI40_02849 6.2e-156 459.0 COG5265@1|root,COG5265@2|Bacteria,1NSKS@1224|Proteobacteria,2WGG3@28216|Betaproteobacteria,473CU@75682|Oxalobacteraceae 28216|Betaproteobacteria V ABC transporter transmembrane region atm1 - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_704646_1 216595.PFLU_0148A 1.18e-56 183.0 COG1943@1|root,COG1943@2|Bacteria,1P19I@1224|Proteobacteria,1RQYI@1236|Gammaproteobacteria 1236|Gammaproteobacteria L COG1943 Transposase and inactivated derivatives - - - ko:K07491 - - - - ko00000 - - - Y1_Tnp k59_367711_1 485915.Dret_1575 2.26e-97 297.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,42WT2@68525|delta/epsilon subdivisions,2WR9X@28221|Deltaproteobacteria,2MAU1@213115|Desulfovibrionales 28221|Deltaproteobacteria L PFAM transposase IS116 IS110 IS902 family protein - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_661721_1 1238182.C882_1327 1.74e-85 256.0 COG3415@1|root,COG3415@2|Bacteria,1RDMQ@1224|Proteobacteria,2U7PU@28211|Alphaproteobacteria,2JZ7V@204441|Rhodospirillales 204441|Rhodospirillales L Winged helix-turn helix - - - - - - - - - - - - HTH_32,HTH_33 k59_704699_1 1121346.KB899820_gene2840 2.51e-06 53.9 COG5301@1|root,COG5301@2|Bacteria,1VEZ9@1239|Firmicutes,4HNUH@91061|Bacilli,26TPX@186822|Paenibacillaceae 91061|Bacilli G cellulose 1,4-beta-cellobiosidase activity - - - - - - - - - - - - - k59_105639_1 1121937.AUHJ01000008_gene2058 5.88e-16 80.1 COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,1RNR3@1236|Gammaproteobacteria,464RV@72275|Alteromonadaceae 1236|Gammaproteobacteria J Glycyl-tRNA synthetase beta subunit glyS GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.14 ko:K01879 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iAPECO1_1312.APECO1_2891,iE2348C_1286.E2348C_3810,iECABU_c1320.ECABU_c40010,iECED1_1282.ECED1_4242,iECH74115_1262.ECH74115_4934,iECNA114_1301.ECNA114_3710,iECOK1_1307.ECOK1_4005,iECP_1309.ECP_3661,iECS88_1305.ECS88_3976,iECSF_1327.ECSF_3393,iECSP_1301.ECSP_4554,iECs_1301.ECs4442,iG2583_1286.G2583_4300,iUMN146_1321.UM146_17960,iUTI89_1310.UTI89_C4099,ic_1306.c4378 DALR_1,tRNA_synt_2f k59_105639_2 522306.CAP2UW1_3699 1.47e-171 483.0 COG0752@1|root,COG0752@2|Bacteria,1MVCJ@1224|Proteobacteria,2VIQX@28216|Betaproteobacteria,1KPPQ@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria J glycyl-tRNA synthetase alpha subunit glyQ - 6.1.1.14 ko:K01878 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2e k59_69773_1 716928.AJQT01000035_gene833 1.38e-17 78.2 COG3793@1|root,COG3793@2|Bacteria,1RD1X@1224|Proteobacteria,2U788@28211|Alphaproteobacteria,4BE4P@82115|Rhizobiaceae 28211|Alphaproteobacteria P PFAM Mo-dependent nitrogenase - - - - - - - - - - - - TerB k59_69773_2 1207063.P24_02031 1.01e-44 161.0 COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,2TUKS@28211|Alphaproteobacteria,2JPAC@204441|Rhodospirillales 204441|Rhodospirillales KL HELICc2 - - 3.6.4.12 ko:K03722 - - - - ko00000,ko01000,ko03400 - - - Helicase_C_2 k59_1258969_1 414684.RC1_4103 2.7e-73 235.0 COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,2TR4H@28211|Alphaproteobacteria,2JPHA@204441|Rhodospirillales 204441|Rhodospirillales E argininosuccinate lyase argH - 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ASL_C2,Lyase_1 k59_24718_1 391612.CY0110_15537 6.04e-31 127.0 COG2931@1|root,COG3291@1|root,COG2931@2|Bacteria,COG3291@2|Bacteria,1G1I0@1117|Cyanobacteria,3KK8R@43988|Cyanothece 1117|Cyanobacteria Q Hemolysin-type calcium-binding repeat (2 copies) - - - - - - - - - - - - Calx-beta,HemolysinCabind,Lectin_C k59_1300782_1 395495.Lcho_4267 2.2e-33 129.0 COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,2VKF8@28216|Betaproteobacteria,1KK3U@119065|unclassified Burkholderiales 28216|Betaproteobacteria V FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1300782_2 639283.Snov_0233 1.27e-10 62.4 COG0845@1|root,COG0845@2|Bacteria,1Q10W@1224|Proteobacteria,2TSC8@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Efflux transporter, RND family, MFP subunit - - - ko:K02005 - - - - ko00000 - - - HlyD_3 k59_1093294_1 105559.Nwat_0394 1.37e-42 150.0 COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,1RNCP@1236|Gammaproteobacteria,1WWQP@135613|Chromatiales 135613|Chromatiales C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis petB - - ko:K00412 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko03029 - - - Cytochrom_B_C,Cytochrome_B k59_1093294_2 1121939.L861_00630 8.58e-36 127.0 COG0723@1|root,COG0723@2|Bacteria,1RAA2@1224|Proteobacteria,1RP9H@1236|Gammaproteobacteria,1XJ8J@135619|Oceanospirillales 135619|Oceanospirillales C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis petA - 1.10.2.2 ko:K00411 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko01000 - - - Rieske,UCR_Fe-S_N k59_406211_1 998088.B565_2892 3.33e-42 152.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,1RQ86@1236|Gammaproteobacteria,1Y3IJ@135624|Aeromonadales 135624|Aeromonadales U General secretion pathway protein F exeF - - ko:K02455 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSF k59_105686_1 76114.ebA3572 1.63e-30 111.0 COG1324@1|root,COG1324@2|Bacteria,1N6TN@1224|Proteobacteria,2VUC8@28216|Betaproteobacteria,2KX0I@206389|Rhodocyclales 206389|Rhodocyclales P protein involved in tolerance to divalent cations cutA1 - - ko:K03926 - - - - ko00000 - - - CutA1 k59_105686_2 1169143.KB911040_gene2975 8.78e-19 85.9 COG0451@1|root,COG0451@2|Bacteria,1MWVJ@1224|Proteobacteria,2VJ3T@28216|Betaproteobacteria,1K0SV@119060|Burkholderiaceae 28216|Betaproteobacteria GM Nad-dependent epimerase dehydratase yeeZ - - - - - - - - - - - Epimerase,NAD_binding_10,RmlD_sub_bind,TrkA_N k59_406264_2 3988.XP_002536270.1 2.64e-07 56.6 2EHAH@1|root,2SN0I@2759|Eukaryota 2759|Eukaryota S Bacterial type II and III secretion system protein - - - - - - - - - - - - Secretin,Secretin_N k59_704824_1 331869.BAL199_03574 6.13e-51 174.0 COG1638@1|root,COG1638@2|Bacteria,1PG0D@1224|Proteobacteria,2TTUQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria G transport system periplasmic component - - - - - - - - - - - - DctP k59_1051020_1 309801.trd_1395 2.92e-09 57.4 COG2368@1|root,COG2368@2|Bacteria,2GBD8@200795|Chloroflexi,27YVT@189775|Thermomicrobia 189775|Thermomicrobia Q 4-hydroxyphenylacetate 3-hydroxylase C terminal - - 1.14.14.9 ko:K00483 ko00350,ko01120,ko01220,map00350,map01120,map01220 - R02698,R03299 RC00046 ko00000,ko00001,ko01000 - - - HpaB,HpaB_N k59_1051020_2 438753.AZC_4188 2.52e-55 176.0 COG1917@1|root,COG1917@2|Bacteria,1RDWP@1224|Proteobacteria,2U7BQ@28211|Alphaproteobacteria,3F1E3@335928|Xanthobacteraceae 28211|Alphaproteobacteria S Cupin 2, conserved barrel domain protein - - - - - - - - - - - - Cupin_7 k59_1051020_3 7230.FBpp0173733 1.26e-05 51.6 COG0625@1|root,KOG0867@2759|Eukaryota,3A0A1@33154|Opisthokonta,3BPQK@33208|Metazoa,3D6F2@33213|Bilateria,41YQK@6656|Arthropoda,3SG1J@50557|Insecta,450I2@7147|Diptera,45R10@7214|Drosophilidae 33208|Metazoa O FLYWCH zinc finger domain - GO:0003674,GO:0003676,GO:0003824,GO:0004364,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006518,GO:0006575,GO:0006749,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016765,GO:0033218,GO:0034641,GO:0042277,GO:0043167,GO:0043168,GO:0043295,GO:0043603,GO:0044237,GO:0044424,GO:0044464,GO:0048037,GO:0051186,GO:0071704,GO:0072341,GO:0097159,GO:1900750,GO:1901363,GO:1901564,GO:1901681 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - FLYWCH,GST_C,GST_C_3,GST_N,GST_N_3 k59_449053_1 95619.PM1_0201590 1.39e-68 221.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,1RNB5@1236|Gammaproteobacteria 1236|Gammaproteobacteria C acyl-CoA transferases carnitine dehydratase coaT - - - - - - - - - - - CoA_transf_3 k59_624499_1 266835.14025743 4.15e-65 209.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_661931_1 926569.ANT_12290 6.11e-84 259.0 COG3464@1|root,COG3464@2|Bacteria,2G9B1@200795|Chloroflexi 200795|Chloroflexi L Transposase IS66 family - - - - - - - - - - - - DDE_Tnp_IS66 k59_235616_1 395495.Lcho_1541 1.31e-66 222.0 COG0484@1|root,COG0484@2|Bacteria,1MXM9@1224|Proteobacteria,2VPQ6@28216|Betaproteobacteria 28216|Betaproteobacteria C heat shock protein binding - - - - - - - - - - - - Cytochrom_CIII k59_105804_1 674977.VMC_09370 3.18e-13 74.7 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1XSRH@135623|Vibrionales 135623|Vibrionales T signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - 3.1.4.52 ko:K20962 ko05111,map05111 - - - ko00000,ko00001,ko01000 - - - EAL,GGDEF,Response_reg k59_964165_1 243160.BMA1684 2.9e-60 195.0 COG0596@1|root,COG0596@2|Bacteria,1QTWQ@1224|Proteobacteria,2WGGA@28216|Betaproteobacteria,1K2V9@119060|Burkholderiaceae 28216|Betaproteobacteria S Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_964165_2 1532557.JL37_01255 8.28e-66 214.0 COG0665@1|root,COG0665@2|Bacteria,1MVIZ@1224|Proteobacteria,2VH1D@28216|Betaproteobacteria,3T1PD@506|Alcaligenaceae 28216|Betaproteobacteria E D-amino acid dehydrogenase dadA4 - 1.4.5.1 ko:K00285 ko00360,map00360 - R01374,R09493 RC00006,RC00025 ko00000,ko00001,ko01000 - - - DAO,FAD_binding_2 k59_832746_1 319003.Bra1253DRAFT_04449 1.14e-52 183.0 COG3852@1|root,COG3852@2|Bacteria,1QU3S@1224|Proteobacteria,2TVY7@28211|Alphaproteobacteria,3K6M1@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T His Kinase A (phosphoacceptor) domain regM - - - - - - - - - - - HATPase_c k59_1352131_1 977880.RALTA_B1495 7.35e-115 356.0 COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,2VP2Q@28216|Betaproteobacteria,1K6SR@119060|Burkholderiaceae 28216|Betaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family fdhA1 - 1.17.1.9,1.17.99.7 ko:K00123,ko:K22015 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Fer2_4,Fer4,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_1055477_1 477184.KYC_24792 1.14e-95 292.0 COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,2VHDZ@28216|Betaproteobacteria,3T1NI@506|Alcaligenaceae 28216|Betaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N k59_921786_1 1265502.KB905936_gene2640 4.51e-56 185.0 COG0082@1|root,COG0082@2|Bacteria,1MU98@1224|Proteobacteria,2VJA4@28216|Betaproteobacteria,4AADA@80864|Comamonadaceae 28216|Betaproteobacteria E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system aroC - 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 - - - Chorismate_synt k59_921786_2 1504672.669782992 2.24e-39 132.0 COG1923@1|root,COG1923@2|Bacteria,1MZM1@1224|Proteobacteria,2VTXK@28216|Betaproteobacteria,4AEZ7@80864|Comamonadaceae 28216|Betaproteobacteria J RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs hfq - - ko:K03666 ko02024,ko03018,ko05111,map02024,map03018,map05111 - - - ko00000,ko00001,ko03019,ko03036 - - - Hfq k59_921786_3 640081.Dsui_3136 1.09e-92 285.0 COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,2VI86@28216|Betaproteobacteria,2KV0C@206389|Rhodocyclales 206389|Rhodocyclales S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis hflX - - ko:K03665 - - - - ko00000,ko03009 - - - GTP-bdg_M,GTP-bdg_N,MMR_HSR1 k59_1131248_1 557598.LHK_00685 1.96e-103 311.0 COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,2VID7@28216|Betaproteobacteria,2KPF1@206351|Neisseriales 206351|Neisseriales I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate ispG - 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 - - - GcpE k59_751204_1 1238182.C882_1376 1.02e-25 110.0 COG2202@1|root,COG5002@1|root,COG2202@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2TZDS@28211|Alphaproteobacteria,2JZ03@204441|Rhodospirillales 204441|Rhodospirillales T Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - HAMP,HATPase_c,HisKA,Hpt,PAS_3,PAS_4,PAS_9,Response_reg k59_280035_1 1267533.KB906733_gene3306 1.17e-13 73.6 COG2802@1|root,COG2802@2|Bacteria,3Y7JR@57723|Acidobacteria,2JMUX@204432|Acidobacteriia 204432|Acidobacteriia S ATP-dependent protease La (LON) substrate-binding domain - - - ko:K07157 - - - - ko00000 - - - LON_substr_bdg k59_797936_2 492774.JQMB01000003_gene2590 5e-42 149.0 COG1902@1|root,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,2U2EY@28211|Alphaproteobacteria,4B9WR@82115|Rhizobiaceae 28211|Alphaproteobacteria C NADH:flavin oxidoreductase / NADH oxidase family - - - - - - - - - - - - Oxidored_FMN k59_1055622_1 1056820.KB900696_gene3940 2.32e-74 241.0 COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,1RNEH@1236|Gammaproteobacteria,2PMQH@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria P ABC transporter nrtC - - ko:K15578 ko00910,ko02010,map00910,map02010 M00438 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.16.1 - - ABC_tran k59_109627_1 411684.HPDFL43_18052 6.4e-34 130.0 COG0471@1|root,COG0490@1|root,COG0471@2|Bacteria,COG0490@2|Bacteria,1MU0K@1224|Proteobacteria,2TSFS@28211|Alphaproteobacteria,43H44@69277|Phyllobacteriaceae 28211|Alphaproteobacteria P Citrate transporter - - - - - - - - - - - - CitMHS,Na_sulph_symp,TrkA_C k59_109627_2 261292.Nit79A3_3262 6.48e-46 155.0 COG2738@1|root,COG2738@2|Bacteria,1RDJH@1224|Proteobacteria,2W832@28216|Betaproteobacteria,372AS@32003|Nitrosomonadales 28216|Betaproteobacteria S Putative neutral zinc metallopeptidase - - - ko:K06973 - - - - ko00000 - - - Zn_peptidase_2 k59_578396_1 2340.JV46_16860 5.14e-14 71.6 COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,1RMKQ@1236|Gammaproteobacteria,1J4KE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine coaBC GO:0000166,GO:0003674,GO:0003824,GO:0004632,GO:0004633,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0010181,GO:0015936,GO:0015937,GO:0016829,GO:0016830,GO:0016831,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032553,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - iEC042_1314.EC042_3945,iECUMN_1333.ECUMN_4154,iJN746.PP_5285,iSBO_1134.SBO_3641 DFP,Flavoprotein k59_578396_2 1123392.AQWL01000006_gene665 1.19e-92 278.0 COG2003@1|root,COG2003@2|Bacteria,1MXZ5@1224|Proteobacteria,2VKTW@28216|Betaproteobacteria,1KSXR@119069|Hydrogenophilales 119069|Hydrogenophilales L RadC-like JAB domain - - - ko:K03630 - - - - ko00000 - - - RadC k59_578396_3 742823.HMPREF9465_01493 6.82e-34 118.0 COG0227@1|root,COG0227@2|Bacteria,1MZ57@1224|Proteobacteria,2VU1B@28216|Betaproteobacteria,4PRAN@995019|Sutterellaceae 28216|Betaproteobacteria J Ribosomal L28 family rpmB - - ko:K02902 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L28 k59_73779_1 550540.Fbal_2786 5.35e-54 192.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family bepG - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_875941_1 1280953.HOC_10309 7.07e-08 58.2 COG1762@1|root,COG1762@2|Bacteria,1RD0E@1224|Proteobacteria,2U7B0@28211|Alphaproteobacteria,43Y7D@69657|Hyphomonadaceae 28211|Alphaproteobacteria G COG1762 Phosphotransferase system mannitol fructose-specific IIA domain (Ntr-type) ptsN - - ko:K02806 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 - - - PTS_EIIA_2 k59_1006787_1 76114.ebA871 3.22e-73 239.0 COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,2VHFD@28216|Betaproteobacteria,2KU9R@206389|Rhodocyclales 206389|Rhodocyclales J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS - 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD k59_921965_1 582744.Msip34_0680 1.23e-11 63.2 COG0839@1|root,COG0839@2|Bacteria,1MWJV@1224|Proteobacteria,2VJ4G@28216|Betaproteobacteria,2KKQS@206350|Nitrosomonadales 206350|Nitrosomonadales C Belongs to the complex I subunit 6 family - - 1.6.5.3 ko:K00339 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q3 k59_921965_2 1288494.EBAPG3_21480 1.46e-55 177.0 COG1143@1|root,COG1143@2|Bacteria,1MV90@1224|Proteobacteria,2VIQP@28216|Betaproteobacteria,371MN@32003|Nitrosomonadales 28216|Betaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoI - 1.6.5.3 ko:K00338 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer4 k59_921975_1 1095769.CAHF01000021_gene882 7.69e-174 508.0 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2VIR8@28216|Betaproteobacteria,4747B@75682|Oxalobacteraceae 28216|Betaproteobacteria C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain coxL - 1.2.5.3 ko:K03520 - - R11168 RC02800 ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_1097989_1 675635.Psed_0016 1.13e-32 130.0 COG4584@1|root,COG4584@2|Bacteria,2GM4J@201174|Actinobacteria,4E0HE@85010|Pseudonocardiales 201174|Actinobacteria L Integrase core domain - GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - rve k59_495591_2 414684.RC1_1377 2.77e-28 103.0 COG1522@1|root,COG1522@2|Bacteria,1MZDV@1224|Proteobacteria,2UBTU@28211|Alphaproteobacteria,2JTEU@204441|Rhodospirillales 204441|Rhodospirillales K COG1522 Transcriptional regulators - - - - - - - - - - - - AsnC_trans_reg k59_328423_1 1005048.CFU_1809 3.05e-75 234.0 28NPW@1|root,2ZBPM@2|Bacteria,1RAMG@1224|Proteobacteria,2VQIF@28216|Betaproteobacteria,4770W@75682|Oxalobacteraceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_1075046_1 1348657.M622_06045 1.12e-68 229.0 COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,2VINT@28216|Betaproteobacteria,2KVAV@206389|Rhodocyclales 206389|Rhodocyclales L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA - - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C k59_51639_1 1033802.SSPSH_000272 9.41e-67 216.0 COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,1RMSU@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC GO:0003674,GO:0003824,GO:0004774,GO:0004775,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016874,GO:0016877,GO:0016878,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Ligase_CoA k59_732214_1 1380393.JHVP01000005_gene3585 3.95e-71 228.0 COG2382@1|root,COG2382@2|Bacteria,2I844@201174|Actinobacteria,4EWT7@85013|Frankiales 201174|Actinobacteria P Putative esterase - - - ko:K07214 - - - - ko00000 - - - DUF3327,Esterase k59_1201151_1 1223521.BBJX01000002_gene2860 1.05e-121 363.0 COG0843@1|root,COG0843@2|Bacteria,1R57U@1224|Proteobacteria,2VJ1N@28216|Betaproteobacteria,4AHFT@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM Cytochrome c oxidase, subunit I cbaA - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 k59_816525_1 497964.CfE428DRAFT_1238 1.28e-66 217.0 COG1032@1|root,COG1032@2|Bacteria 2|Bacteria C radical SAM domain protein - - - - - - - - - - - - B12-binding,DUF4070,Radical_SAM k59_988029_2 574966.KB898647_gene2463 0.00018 42.4 COG1734@1|root,COG1734@2|Bacteria,1MZIB@1224|Proteobacteria,1S8SP@1236|Gammaproteobacteria,1XM3C@135619|Oceanospirillales 135619|Oceanospirillales T Prokaryotic dksA/traR C4-type zinc finger - - - - - - - - - - - - zf-dskA_traR k59_433997_1 1123229.AUBC01000008_gene445 2.02e-92 280.0 COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2TS33@28211|Alphaproteobacteria,3JQMM@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Belongs to the cysteine synthase cystathionine beta- synthase family cysK - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_1158563_1 1235457.C404_13690 1.2e-104 330.0 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,2VH5Z@28216|Betaproteobacteria,1K21B@119060|Burkholderiaceae 28216|Betaproteobacteria J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS - 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_92200_1 497321.C664_09813 8.39e-114 335.0 COG2010@1|root,COG2010@2|Bacteria,1MUCW@1224|Proteobacteria,2VHGS@28216|Betaproteobacteria,2KUZH@206389|Rhodocyclales 206389|Rhodocyclales C C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex ccoP - - ko:K00406 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - Cytochrome_CBB3,FixP_N k59_1286160_1 1502852.FG94_03110 5.27e-59 199.0 COG1538@1|root,COG1538@2|Bacteria,1MWCJ@1224|Proteobacteria,2VHG1@28216|Betaproteobacteria,473DE@75682|Oxalobacteraceae 28216|Betaproteobacteria MU TIGRFAM type I secretion outer membrane protein, TolC family tolC - - ko:K12340 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 - - OEP k59_1243907_1 323848.Nmul_A0998 5.58e-18 82.8 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,2VHQ3@28216|Betaproteobacteria,372G3@32003|Nitrosomonadales 28216|Betaproteobacteria H Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate ppsA - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_1243907_2 1502852.FG94_05022 4.54e-115 339.0 COG1806@1|root,COG1806@2|Bacteria,1MUHU@1224|Proteobacteria,2VI4R@28216|Betaproteobacteria,472KF@75682|Oxalobacteraceae 28216|Betaproteobacteria F Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation dephosphorylation ydiA - 2.7.11.33,2.7.4.28 ko:K09773 - - - - ko00000,ko01000 - - - Kinase-PPPase k59_988083_1 864051.BurJ1DRAFT_3799 1.38e-16 79.7 COG2937@1|root,COG2937@2|Bacteria,1MWZ6@1224|Proteobacteria,2W5VT@28216|Betaproteobacteria 28216|Betaproteobacteria I Belongs to the GPAT DAPAT family plsB - 2.3.1.15 ko:K00631 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_988083_2 640081.Dsui_2899 1.84e-22 95.1 COG0697@1|root,COG0697@2|Bacteria,1MXVF@1224|Proteobacteria,2VKMQ@28216|Betaproteobacteria,2KVQX@206389|Rhodocyclales 206389|Rhodocyclales EG EamA-like transporter family - - - - - - - - - - - - EamA k59_816580_1 1125863.JAFN01000001_gene535 5.58e-34 131.0 COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,42R6N@68525|delta/epsilon subdivisions,2WP3W@28221|Deltaproteobacteria 28221|Deltaproteobacteria M PFAM Glycosyl transferase, group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_606351_1 426117.M446_6911 5.76e-51 177.0 COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria 1224|Proteobacteria S transport system periplasmic component - - - ko:K01989 - M00247 - - ko00000,ko00002,ko02000 - - - ABC_sub_bind k59_816590_1 331869.BAL199_20285 1.18e-82 257.0 COG1653@1|root,COG1653@2|Bacteria,1MU64@1224|Proteobacteria,2TTUB@28211|Alphaproteobacteria,4BRJR@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria G Bacterial extracellular solute-binding protein - - - ko:K02027 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - SBP_bac_1,SBP_bac_8,TAT_signal k59_816590_2 1297570.MESS4_530087 9.67e-11 61.6 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQQJ@28211|Alphaproteobacteria,43IBF@69277|Phyllobacteriaceae 28211|Alphaproteobacteria P Belongs to the ABC transporter superfamily - - - ko:K10112 ko02010,map02010 M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1 - - ABC_tran,TOBE_2 k59_1286184_1 1068978.AMETH_3117 6.41e-37 140.0 COG3653@1|root,COG3653@2|Bacteria,2GKMK@201174|Actinobacteria,4E9YI@85010|Pseudonocardiales 201174|Actinobacteria Q Amidohydrolase family - - 3.5.1.81,3.5.2.3 ko:K01465,ko:K06015 ko00240,ko01100,map00240,map01100 M00051 R01993,R02192 RC00064,RC00328,RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_3 k59_220740_1 1380355.JNIJ01000006_gene3041 6.1e-105 315.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,3JR1M@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L PFAM transposase IS116 IS110 IS902 family - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_349962_1 948106.AWZT01000021_gene2933 1.11e-125 379.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,2VI1P@28216|Betaproteobacteria,1K2EF@119060|Burkholderiaceae 28216|Betaproteobacteria J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_178309_1 1209072.ALBT01000035_gene1400 1.16e-18 92.8 COG4775@1|root,COG4775@2|Bacteria,1PT0R@1224|Proteobacteria,1RPWY@1236|Gammaproteobacteria,1FGVX@10|Cellvibrio 1236|Gammaproteobacteria M COG4775 Outer membrane protein protective antigen OMA87 - - - - - - - - - - - - Bac_surface_Ag,ShlB k59_689797_1 76114.ebA172 5.13e-86 272.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VIP3@28216|Betaproteobacteria,2KUJV@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_689797_2 748247.AZKH_p0190 8.42e-05 42.0 2DNR5@1|root,32YQH@2|Bacteria,1NBXJ@1224|Proteobacteria,2VW7K@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_1075267_1 1123366.TH3_06660 4.23e-59 195.0 COG0470@1|root,COG0470@2|Bacteria,1MY1W@1224|Proteobacteria,2TV3E@28211|Alphaproteobacteria,2JR92@204441|Rhodospirillales 204441|Rhodospirillales L DNA polymerase III subunit delta holB - 2.7.7.7 ko:K02341 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2 k59_1330417_2 570967.JMLV01000002_gene1768 3.34e-80 257.0 COG0477@1|root,COG2814@2|Bacteria,1MW59@1224|Proteobacteria,2TRA3@28211|Alphaproteobacteria,2JQ7C@204441|Rhodospirillales 204441|Rhodospirillales EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_1032786_1 1357275.AVEL02000082_gene642 5.06e-26 110.0 COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,1S1KY@1236|Gammaproteobacteria,1Z535@136849|Pseudomonas syringae group 1236|Gammaproteobacteria M Mycolic acid cyclopropane synthetase cfa2 - 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - - CMAS k59_1158683_1 762376.AXYL_03833 2.91e-23 100.0 COG0583@1|root,COG0583@2|Bacteria,1P2I1@1224|Proteobacteria,2W0R2@28216|Betaproteobacteria,3T59X@506|Alcaligenaceae 28216|Betaproteobacteria K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_1075282_1 1161401.ASJA01000033_gene3049 2e-79 249.0 COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,2TS83@28211|Alphaproteobacteria,43WYN@69657|Hyphomonadaceae 28211|Alphaproteobacteria E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate proA - 1.2.1.41 ko:K00147 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 M00015 R03313 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_606448_1 339670.Bamb_1932 1.55e-125 395.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,2VI7M@28216|Betaproteobacteria,1K06P@119060|Burkholderiaceae 28216|Betaproteobacteria L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_308081_1 113395.AXAI01000011_gene6533 8.33e-38 142.0 COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S ABC transporter substrate binding protein - - - ko:K01989 - M00247 - - ko00000,ko00002,ko02000 - - - ABC_sub_bind k59_262820_1 497321.C664_09090 1.94e-119 377.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,2VHF3@28216|Betaproteobacteria,2KV0Q@206389|Rhodocyclales 206389|Rhodocyclales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_92310_1 936455.KI421499_gene7382 1.47e-200 573.0 COG2072@1|root,COG2072@2|Bacteria,1MWPJ@1224|Proteobacteria,2TT05@28211|Alphaproteobacteria,3JS8N@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P Flavin-binding monooxygenase-like - - - - - - - - - - - - Pyr_redox_3 k59_1201339_1 857087.Metme_0181 2.94e-26 104.0 COG3220@1|root,COG3220@2|Bacteria,1MURE@1224|Proteobacteria,1RQ9H@1236|Gammaproteobacteria,1XF0D@135618|Methylococcales 135618|Methylococcales S Protein of unknown function (DUF692) - - - ko:K09930 - - - - ko00000 - - - DUF692 k59_1201339_2 658187.LDG_9050 4.47e-15 71.2 COG5572@1|root,COG5572@2|Bacteria,1PCZI@1224|Proteobacteria,1SDT0@1236|Gammaproteobacteria,1JEZ9@118969|Legionellales 118969|Legionellales S Predicted integral membrane protein (DUF2282) - - - - - - - - - - - - DUF2282 k59_134816_1 323848.Nmul_A0639 3.16e-137 422.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,2VI7M@28216|Betaproteobacteria,372K8@32003|Nitrosomonadales 28216|Betaproteobacteria L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_816704_1 28229.ND2E_3926 5.76e-62 215.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,2Q7E9@267889|Colwelliaceae 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_902971_1 1114179.I2FLR4_9CAUD 2.37e-17 84.7 4QFN3@10239|Viruses,4QZSZ@35237|dsDNA viruses no RNA stage,4QQ4M@28883|Caudovirales,4QNXC@10744|Podoviridae 10744|Podoviridae S exonuclease activity - - - - - - - - - - - - - k59_689892_1 1211115.ALIQ01000066_gene3459 1.75e-33 131.0 COG1524@1|root,COG1524@2|Bacteria,1PTI0@1224|Proteobacteria,2TUW7@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Type I phosphodiesterase / nucleotide pyrophosphatase - - - - - - - - - - - - Phosphodiest k59_606528_1 742765.HMPREF9457_00470 1.04e-22 101.0 COG1215@1|root,COG3222@1|root,COG1215@2|Bacteria,COG3222@2|Bacteria,1UFV7@1239|Firmicutes,24BR5@186801|Clostridia,27WM0@189330|Dorea 186801|Clostridia M Guanylyl transferase CofC like - - - - - - - - - - - - DUF2064,Glycos_transf_2 k59_434205_1 2340.JV46_05690 6.38e-144 415.0 COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,1RN7B@1236|Gammaproteobacteria,1JBRQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L L COG2826 Transposase and inactivated derivatives, IS30 family insI GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004803,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006310,GO:0006313,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0030983,GO:0032135,GO:0032196,GO:0032991,GO:0032993,GO:0034641,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363 - ko:K07482 - - - - ko00000 - - - HTH_38,rve k59_220863_1 243233.MCA0573 5.46e-45 158.0 COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,1RNNW@1236|Gammaproteobacteria,1XDM6@135618|Methylococcales 135618|Methylococcales I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) dxr - 1.1.1.267 ko:K00099 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05688 RC01452 ko00000,ko00001,ko00002,ko01000 - - - DXPR_C,DXP_redisom_C,DXP_reductoisom k59_220863_2 640512.BC1003_1295 4.46e-34 129.0 COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,2VHBW@28216|Betaproteobacteria,1JZSU@119060|Burkholderiaceae 28216|Betaproteobacteria M zinc metalloprotease rseP - - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_M50 k59_262892_1 859657.RPSI07_0688 1.47e-156 450.0 COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,2VISR@28216|Betaproteobacteria,1K327@119060|Burkholderiaceae 28216|Betaproteobacteria F Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate proB - 2.7.2.11 ko:K00931 ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230 M00015 R00239 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,PUA k59_1330557_1 1265505.ATUG01000001_gene4659 1.27e-22 97.8 COG1638@1|root,COG1638@2|Bacteria,1PJFW@1224|Proteobacteria,42PXK@68525|delta/epsilon subdivisions,2WJFU@28221|Deltaproteobacteria,2MJCH@213118|Desulfobacterales 28221|Deltaproteobacteria G PFAM Bacterial extracellular solute-binding protein, family 7 - - - - - - - - - - - - DctP k59_776441_1 1382306.JNIM01000001_gene2376 9.83e-31 122.0 COG0146@1|root,COG0146@2|Bacteria,2G644@200795|Chloroflexi 200795|Chloroflexi EQ PFAM Hydantoinase B oxoprolinase - - 3.5.2.14 ko:K01474 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydantoinase_B k59_134864_1 1158292.JPOE01000002_gene3224 0.00022 42.7 COG3703@1|root,COG3703@2|Bacteria,1QA7D@1224|Proteobacteria,2VQKU@28216|Betaproteobacteria,1KKY0@119065|unclassified Burkholderiales 28216|Betaproteobacteria P Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides chaC - - ko:K07232 - - - - ko00000 - - - ChaC k59_134864_2 1121378.KB899729_gene4105 4.41e-59 189.0 COG4032@1|root,COG4032@2|Bacteria 2|Bacteria EH Thiamine pyrophosphate enzyme, N-terminal TPP binding domain MA20_16825 - - - - - - - - - - - TPP_enzyme_N k59_476782_1 257313.BP2200 7.6e-15 75.1 COG1426@1|root,COG1426@2|Bacteria,1NIQS@1224|Proteobacteria,2VYKY@28216|Betaproteobacteria,3T4VW@506|Alcaligenaceae 28216|Betaproteobacteria S Helix-turn-helix domain - - - ko:K15539 - - - - ko00000 - - - HTH_25 k59_476782_2 1123392.AQWL01000004_gene2703 1.74e-13 70.1 COG3063@1|root,COG3063@2|Bacteria,1MXPC@1224|Proteobacteria,2VNC8@28216|Betaproteobacteria,1KRTF@119069|Hydrogenophilales 119069|Hydrogenophilales NU Tetratricopeptide repeat - - - ko:K02656 - - - - ko00000,ko02035,ko02044 - - - TPR_8 k59_266435_1 935557.ATYB01000009_gene734 1.08e-61 221.0 COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,4BBZJ@82115|Rhizobiaceae 28211|Alphaproteobacteria T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_7,PAS_9 k59_1335408_1 1163617.SCD_n01709 2.88e-76 229.0 COG1734@1|root,COG1734@2|Bacteria,1RD08@1224|Proteobacteria,2VRPJ@28216|Betaproteobacteria 28216|Betaproteobacteria T Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters dksA - - ko:K06204 ko02026,map02026 - - - ko00000,ko00001,ko03000,ko03009,ko03021 - - - zf-dskA_traR k59_1162865_1 906968.Trebr_1155 1.73e-33 131.0 COG2204@1|root,COG2204@2|Bacteria,2J5NY@203691|Spirochaetes 203691|Spirochaetes T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains rrp-2 - - ko:K02481 - - - - ko00000,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_781388_1 469382.Hbor_17150 7.82e-20 93.6 COG3119@1|root,arCOG02785@2157|Archaea,2XUB1@28890|Euryarchaeota,241AM@183963|Halobacteria 183963|Halobacteria P Sulfatase - - - - - - - - - - - - Sulfatase k59_13845_1 1380355.JNIJ01000010_gene1457 2.47e-61 199.0 COG0614@1|root,COG0614@2|Bacteria,1NVK4@1224|Proteobacteria,2TRJ0@28211|Alphaproteobacteria,3JVNC@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P Periplasmic binding protein - - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 k59_1290278_1 1268622.AVS7_02789 6.7e-06 48.1 COG4324@1|root,COG4324@2|Bacteria,1N0FE@1224|Proteobacteria,2VH73@28216|Betaproteobacteria,4A9QN@80864|Comamonadaceae 28216|Betaproteobacteria S Putative aminopeptidase - - - - - - - - - - - - Aminopep k59_480882_1 1121946.AUAX01000019_gene7787 1.58e-40 146.0 COG0277@1|root,COG0277@2|Bacteria,2GKQR@201174|Actinobacteria,4DAVD@85008|Micromonosporales 201174|Actinobacteria C FAD linked oxidase domain protein - - - - - - - - - - - - FAD_binding_4 k59_480882_2 338969.Rfer_0826 2.98e-21 92.4 COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,2VSBW@28216|Betaproteobacteria,4AGV6@80864|Comamonadaceae 28216|Betaproteobacteria M Mycolic acid cyclopropane synthetase - - 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - - CMAS k59_736636_1 580332.Slit_0270 2.4e-05 47.8 COG3071@1|root,COG3071@2|Bacteria,1MU7A@1224|Proteobacteria,2VK6P@28216|Betaproteobacteria,44VZN@713636|Nitrosomonadales 28216|Betaproteobacteria H HemY protein N-terminus hemY - - ko:K02498 - - - - ko00000 - - - HemY_N,TPR_12 k59_736636_2 305700.B447_21277 1.34e-19 92.0 COG1587@1|root,COG2959@1|root,COG1587@2|Bacteria,COG2959@2|Bacteria,1MY3A@1224|Proteobacteria,2VMG1@28216|Betaproteobacteria,2KW9U@206389|Rhodocyclales 206389|Rhodocyclales H HemX, putative uroporphyrinogen-III C-methyltransferase hemX - 2.1.1.107 ko:K02496 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03194 RC00003,RC00871 ko00000,ko00001,ko00002,ko01000 - - - HemX k59_395364_1 991905.SL003B_2636 1.23e-50 172.0 COG1363@1|root,COG1363@2|Bacteria,1MXEU@1224|Proteobacteria,2TSPX@28211|Alphaproteobacteria,4BPCS@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria G M42 glutamyl aminopeptidase - - - - - - - - - - - - Peptidase_M42 k59_395364_2 991905.SL003B_2637 7.5e-44 156.0 COG0189@1|root,COG0454@1|root,COG0189@2|Bacteria,COG0456@2|Bacteria,1MVN2@1224|Proteobacteria,2TUT9@28211|Alphaproteobacteria,4BPVV@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria HJK FR47-like protein cphA - - - - - - - - - - - Acetyltransf_1,Dala_Dala_lig_C,GSH-S_ATP,RimK k59_438314_1 1173263.Syn7502_03004 5.89e-12 70.9 COG0715@1|root,COG0715@2|Bacteria 2|Bacteria P thiamine-containing compound biosynthetic process - - - ko:K02051 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - NMT1,NMT1_2 k59_1038096_1 305700.B447_01456 4.49e-78 253.0 COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,2VIBW@28216|Betaproteobacteria,2KVF9@206389|Rhodocyclales 206389|Rhodocyclales L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL - - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C k59_781460_1 414996.IL38_18485 1.23e-07 57.4 COG3427@1|root,COG3427@2|Bacteria,2GKTQ@201174|Actinobacteria,4082Z@622450|Actinopolysporales 201174|Actinobacteria S Carbon monoxide dehydrogenase subunit G (CoxG) - - - - - - - - - - - - COXG k59_781460_2 1218074.BAXZ01000003_gene785 2.98e-62 200.0 COG0714@1|root,COG0714@2|Bacteria,1MV5I@1224|Proteobacteria,2VIJR@28216|Betaproteobacteria,1K34U@119060|Burkholderiaceae 28216|Betaproteobacteria S AAA domain (dynein-related subfamily) - - - - - - - - - - - - AAA_5 k59_1335508_1 1211115.ALIQ01000188_gene661 5.05e-44 166.0 2CENN@1|root,32VYV@2|Bacteria,1N4RC@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_651170_1 215803.DB30_1611 2.16e-12 69.3 COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,42MSJ@68525|delta/epsilon subdivisions,2WKHJ@28221|Deltaproteobacteria,2YW9B@29|Myxococcales 28221|Deltaproteobacteria E Receptor family ligand binding region - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_736686_1 640081.Dsui_1946 9.84e-78 243.0 COG2956@1|root,COG2956@2|Bacteria,1MVDP@1224|Proteobacteria,2VH49@28216|Betaproteobacteria,2KU7Z@206389|Rhodocyclales 206389|Rhodocyclales G Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane lapB - - ko:K19804 - - - - ko00000 - - - TPR_16 k59_96071_1 1449350.OCH239_17490 2.88e-78 240.0 COG3917@1|root,COG3917@2|Bacteria,1MV6E@1224|Proteobacteria,2TVJ4@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q 2-hydroxychromene-2-carboxylate isomerase - - - - - - - - - - - - DSBA k59_96071_2 443218.AS9A_0788 3.84e-12 67.0 COG2267@1|root,COG2267@2|Bacteria,2GM96@201174|Actinobacteria,23E32@1762|Mycobacteriaceae 201174|Actinobacteria I TAP-like protein - - 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 - - - Abhydrolase_1,Abhydrolase_6,Hydrolase_4 k59_313352_1 570967.JMLV01000001_gene2470 2.72e-60 196.0 COG0351@1|root,COG0351@2|Bacteria,1MU9J@1224|Proteobacteria,2TUKR@28211|Alphaproteobacteria,2JPMV@204441|Rhodospirillales 204441|Rhodospirillales H Phosphomethylpyrimidine kinase thiD - 2.7.1.49,2.7.4.7 ko:K00941 ko00730,ko01100,map00730,map01100 M00127 R03471,R04509 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Phos_pyr_kin k59_438367_1 1437448.AZRT01000157_gene332 4.72e-09 54.3 COG2963@1|root,COG2963@2|Bacteria,1RHKX@1224|Proteobacteria,2U9TV@28211|Alphaproteobacteria 28211|Alphaproteobacteria L COG2963 Transposase and inactivated derivatives - - - - - - - - - - - - HTH_Tnp_1 k59_438367_2 1123360.thalar_02506 3.05e-181 509.0 COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,1PBHA@1224|Proteobacteria,2TRQF@28211|Alphaproteobacteria 28211|Alphaproteobacteria L COG2801 Transposase and inactivated derivatives - - - - - - - - - - - - HTH_32,rve k59_781522_1 349521.HCH_05083 3e-26 111.0 COG3225@1|root,COG3225@2|Bacteria,1MY63@1224|Proteobacteria,1RP5E@1236|Gammaproteobacteria,1XNPF@135619|Oceanospirillales 135619|Oceanospirillales N ABC-type uncharacterized transport system - - - - - - - - - - - - ABC_transp_aux k59_1080607_1 439235.Dalk_4744 6.69e-08 62.4 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,42P7N@68525|delta/epsilon subdivisions,2WJKE@28221|Deltaproteobacteria,2MICX@213118|Desulfobacterales 28221|Deltaproteobacteria S Insulinase (Peptidase family M16) - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C k59_907268_1 1192868.CAIU01000009_gene1193 3.53e-44 156.0 COG3049@1|root,COG3049@2|Bacteria,1MWPQ@1224|Proteobacteria,2TTPI@28211|Alphaproteobacteria,43IXW@69277|Phyllobacteriaceae 28211|Alphaproteobacteria M Linear amide C-N hydrolases, choloylglycine hydrolase family - - 3.5.1.24 ko:K01442 ko00120,ko00121,ko01100,map00120,map00121,map01100 - R02797,R03975,R03977,R04486,R04487,R05835 RC00090,RC00096 ko00000,ko00001,ko01000 - - - CBAH k59_1335629_1 1123518.ARWI01000001_gene1641 4.95e-152 439.0 COG2132@1|root,COG2132@2|Bacteria,1R89G@1224|Proteobacteria,1S5X0@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Multicopper oxidase - - - - - - - - - - - - Cu-oxidase,Cu-oxidase_3 k59_564942_1 1532557.JL37_09540 2.33e-91 278.0 COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,2W0NK@28216|Betaproteobacteria,3T645@506|Alcaligenaceae 28216|Betaproteobacteria EP Oligopeptide/dipeptide transporter, C-terminal region - - - ko:K02031 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_57236_1 1205680.CAKO01000002_gene2556 7.76e-29 112.0 COG0604@1|root,COG0604@2|Bacteria,1MXUX@1224|Proteobacteria,2TTWF@28211|Alphaproteobacteria,2JVF5@204441|Rhodospirillales 204441|Rhodospirillales C Zinc-binding dehydrogenase - - - - - - - - - - - - ADH_N,ADH_zinc_N k59_57236_2 1157708.KB907461_gene1583 9.3e-08 54.7 COG3491@1|root,COG3491@2|Bacteria,1MUNT@1224|Proteobacteria,2VPPT@28216|Betaproteobacteria,4AEVR@80864|Comamonadaceae 28216|Betaproteobacteria C Belongs to the iron ascorbate-dependent oxidoreductase family - - - - - - - - - - - - 2OG-FeII_Oxy,DIOX_N k59_96156_1 936455.KI421499_gene3206 1.49e-42 159.0 COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,3JTQ7@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - AAA_16,DZR,Guanylate_cyc,SAM_1 k59_395526_1 266834.SM_b20458 5.96e-21 95.9 COG0451@1|root,COG0451@2|Bacteria,1MXKV@1224|Proteobacteria,2TRM0@28211|Alphaproteobacteria,4BA55@82115|Rhizobiaceae 28211|Alphaproteobacteria GM dTDP-glucose 4-6-dehydratase - - 4.1.1.35 ko:K08678 ko00520,ko01100,map00520,map01100 M00361 R01384 RC00508 ko00000,ko00001,ko00002,ko01000 - - - Epimerase,GDP_Man_Dehyd k59_96161_1 204773.HEAR2073 2.18e-115 341.0 COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,2VI6I@28216|Betaproteobacteria,472UE@75682|Oxalobacteraceae 28216|Betaproteobacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP fabF GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0016740,GO:0016746,GO:0016747,GO:0033817 2.3.1.179 ko:K00646,ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004,ko01008 - - - Ketoacyl-synt_C,ketoacyl-synt k59_395542_1 85643.Tmz1t_2957 4.37e-39 138.0 COG1633@1|root,COG1633@2|Bacteria,1RJFW@1224|Proteobacteria,2VT5X@28216|Betaproteobacteria,2KWJT@206389|Rhodocyclales 206389|Rhodocyclales S Rubrerythrin - - - - - - - - - - - - Rubrerythrin k59_395542_2 1244869.H261_12176 2.36e-60 189.0 COG0251@1|root,COG0251@2|Bacteria,1RHSP@1224|Proteobacteria,2U9A9@28211|Alphaproteobacteria,2JSX2@204441|Rhodospirillales 204441|Rhodospirillales J translation initiation inhibitor, yjgF family - - - - - - - - - - - - Ribonuc_L-PSP k59_129981_1 331869.BAL199_26212 1.21e-52 174.0 COG0411@1|root,COG0411@2|Bacteria,1R5MA@1224|Proteobacteria,2TV7Q@28211|Alphaproteobacteria,4BRYV@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E ATPases associated with a variety of cellular activities - - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran k59_129981_2 1121918.ARWE01000001_gene3418 1.56e-70 219.0 COG0410@1|root,COG0410@2|Bacteria,1R5HF@1224|Proteobacteria 1224|Proteobacteria E COG0410 ABC-type branched-chain amino acid transport systems ATPase component - - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran k59_897346_1 264198.Reut_C6314 2.21e-16 79.7 COG2368@1|root,COG2368@2|Bacteria,1PEQG@1224|Proteobacteria,2VKCH@28216|Betaproteobacteria,1K3N6@119060|Burkholderiaceae 28216|Betaproteobacteria Q 4-hydroxyphenylacetate - - 1.14.14.9,4.2.1.120,5.3.3.3 ko:K00483,ko:K14534 ko00350,ko00650,ko00720,ko01100,ko01120,ko01200,ko01220,map00350,map00650,map00720,map01100,map01120,map01200,map01220 M00374,M00375 R02698,R03031,R03299,R10782 RC00046,RC01857,RC03277 ko00000,ko00001,ko00002,ko01000 - - - HpaB,HpaB_N k59_129983_1 713587.THITH_08540 1.02e-124 364.0 COG0702@1|root,COG0702@2|Bacteria,1N12V@1224|Proteobacteria,1S93R@1236|Gammaproteobacteria 1236|Gammaproteobacteria GM NmrA-like family - - - - - - - - - - - - NmrA k59_129983_2 323848.Nmul_A1510 7.85e-31 121.0 COG0397@1|root,COG0397@2|Bacteria,1MVK3@1224|Proteobacteria,2VH7S@28216|Betaproteobacteria,3724K@32003|Nitrosomonadales 28216|Betaproteobacteria S Uncharacterized ACR, YdiU/UPF0061 family - - - - - - - - - - - - UPF0061 k59_1195745_2 472759.Nhal_3920 9.33e-54 178.0 COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,1RMBI@1236|Gammaproteobacteria,1WWWF@135613|Chromatiales 135613|Chromatiales J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner ychF - - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,YchF-GTPase_C k59_87431_1 497321.C664_00100 2.16e-61 191.0 COG1959@1|root,COG1959@2|Bacteria,1RDA4@1224|Proteobacteria,2VRGK@28216|Betaproteobacteria,2KWEM@206389|Rhodocyclales 206389|Rhodocyclales K Transcriptional regulator iscR - - ko:K13643 - - - - ko00000,ko03000 - - - Rrf2 k59_87431_2 497321.C664_00095 1.18e-63 203.0 COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,2VH8C@28216|Betaproteobacteria,2KVCE@206389|Rhodocyclales 206389|Rhodocyclales E serine acetyltransferase cysE - 2.3.1.30 ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 M00021 R00586 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - Hexapep k59_471119_1 926569.ANT_01020 1.54e-47 164.0 COG3464@1|root,COG3464@2|Bacteria,2G9B1@200795|Chloroflexi 200795|Chloroflexi L Transposase IS66 family - - - - - - - - - - - - DDE_Tnp_IS66 k59_684276_1 93220.LV28_13545 5.57e-37 136.0 COG3258@1|root,COG3258@2|Bacteria,1MXB0@1224|Proteobacteria,2VJ8Q@28216|Betaproteobacteria,1K2BG@119060|Burkholderiaceae 28216|Betaproteobacteria C Thiosulfate-oxidizing multienzyme system protein SoxA soxA - - ko:K17222 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - - k59_897359_1 1366050.N234_36240 3.5e-59 193.0 COG5486@1|root,COG5486@2|Bacteria,1NFSK@1224|Proteobacteria,2VZZR@28216|Betaproteobacteria,1KI9K@119060|Burkholderiaceae 28216|Betaproteobacteria S Predicted metal-binding integral membrane protein (DUF2182) - - - - - - - - - - - - DUF2182 k59_599616_2 90371.CY43_09670 5.8e-05 49.3 2E3MG@1|root,32YJP@2|Bacteria,1NAXS@1224|Proteobacteria,1SFQQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_301246_1 85982.XP_007322914.1 1.92e-37 146.0 COG5108@1|root,KOG1038@2759|Eukaryota,38EAY@33154|Opisthokonta,3NU1C@4751|Fungi,3UZF7@5204|Basidiomycota,224YH@155619|Agaricomycetes 4751|Fungi KL DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates RPO41 GO:0000002,GO:0000428,GO:0000959,GO:0001018,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003896,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006269,GO:0006351,GO:0006390,GO:0006725,GO:0006807,GO:0006996,GO:0007005,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0031974,GO:0032774,GO:0032991,GO:0034062,GO:0034245,GO:0034641,GO:0034645,GO:0034654,GO:0042645,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0061695,GO:0070013,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097659,GO:0097747,GO:0098798,GO:0140053,GO:0140098,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K10908 - - - - ko00000,ko01000,ko03029 - - - RNA_pol,RPOL_N k59_811913_1 1267535.KB906767_gene4325 4.75e-34 135.0 COG1132@1|root,COG1132@2|Bacteria,3Y32T@57723|Acidobacteria,2JIBZ@204432|Acidobacteriia 204432|Acidobacteriia V ABC transporter, transmembrane - - - ko:K18889 ko02010,map02010 M00707 - - ko00000,ko00001,ko00002,ko02000 3.A.1.106.13,3.A.1.106.5 - - ABC_membrane,ABC_tran k59_1195804_1 1454004.AW11_03874 2.73e-74 245.0 COG2885@1|root,COG3808@1|root,COG2885@2|Bacteria,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,2VI3K@28216|Betaproteobacteria,1KQ7I@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria C Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase,OmpA k59_684333_1 886293.Sinac_7011 5.49e-73 245.0 COG1413@1|root,COG2010@1|root,COG2133@1|root,COG2755@1|root,COG3794@1|root,COG1413@2|Bacteria,COG2010@2|Bacteria,COG2133@2|Bacteria,COG2755@2|Bacteria,COG3794@2|Bacteria,2IX6X@203682|Planctomycetes 203682|Planctomycetes C Membrane-bound dehydrogenase domain protein - - - - - - - - - - - - Copper-bind,Cytochrom_C,Cytochrome_CBB3,F5_F8_type_C,HEAT_2,Lipase_GDSL_2 k59_385688_1 1288494.EBAPG3_16120 3.04e-51 167.0 COG0247@1|root,COG0247@2|Bacteria,1RF02@1224|Proteobacteria,2VQUX@28216|Betaproteobacteria,372TE@32003|Nitrosomonadales 28216|Betaproteobacteria C Protein of unknown function (DUF3501) - - - - - - - - - - - - DUF3501 k59_385688_2 420662.Mpe_A2098 7.81e-79 236.0 COG1592@1|root,COG1592@2|Bacteria,1R9WG@1224|Proteobacteria,2VQ31@28216|Betaproteobacteria,1KKQS@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Rubrerythrin - - - - - - - - - - - - Rubrerythrin k59_982714_1 1131553.JIBI01000017_gene580 2.44e-65 208.0 COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,2VQNU@28216|Betaproteobacteria,37239@32003|Nitrosomonadales 28216|Betaproteobacteria J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance ctc - - ko:K02897 ko03010,map03010 M00178 - - ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L25p,Ribosomal_TL5_C k59_513862_1 570967.JMLV01000002_gene1817 2.62e-38 135.0 COG3030@1|root,COG3030@2|Bacteria,1MZJJ@1224|Proteobacteria,2UF72@28211|Alphaproteobacteria,2JTD3@204441|Rhodospirillales 204441|Rhodospirillales S COG3030 Protein affecting phage T7 exclusion by the F plasmid fxsA - - ko:K07113 - - - - ko00000 - - - FxsA k59_343471_1 159087.Daro_0252 3.88e-75 235.0 COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,2VHRM@28216|Betaproteobacteria,2KV48@206389|Rhodocyclales 206389|Rhodocyclales U Belongs to the binding-protein-dependent transport system permease family - - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_343471_2 62928.azo3445 5.08e-87 264.0 COG0559@1|root,COG0559@2|Bacteria,1N54M@1224|Proteobacteria,2VIID@28216|Betaproteobacteria,2KVZ8@206389|Rhodocyclales 206389|Rhodocyclales U Belongs to the binding-protein-dependent transport system permease family - - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_471227_1 543526.Htur_0970 2.51e-25 109.0 arCOG02329@1|root,arCOG02360@1|root,arCOG07605@1|root,arCOG02329@2157|Archaea,arCOG02360@2157|Archaea,arCOG07605@2157|Archaea,2Y5ZU@28890|Euryarchaeota 28890|Euryarchaeota T Histidine kinase - - - - - - - - - - - - GAF,HATPase_c,HisKA,PAS_4,PAS_9 k59_471227_2 443598.AUFA01000003_gene2250 3.09e-41 147.0 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2TQN9@28211|Alphaproteobacteria,3JVM1@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Pyridoxal-phosphate dependent enzyme MA20_41440 - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - ACT,ACT_4,PALP k59_1195864_1 1380394.JADL01000016_gene399 3.95e-97 295.0 COG0579@1|root,COG0579@2|Bacteria,1N0QB@1224|Proteobacteria,2TU6K@28211|Alphaproteobacteria,2JQVK@204441|Rhodospirillales 204441|Rhodospirillales S FAD dependent oxidoreductase - - - - - - - - - - - - DAO k59_343498_1 391165.GbCGDNIH1_1490 1.02e-25 109.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2TQPZ@28211|Alphaproteobacteria,2JQVG@204441|Rhodospirillales 204441|Rhodospirillales O Belongs to the peptidase S1C family - - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_1073473_1 1231391.AMZF01000015_gene2215 8.18e-49 166.0 COG0559@1|root,COG0559@2|Bacteria,1MVND@1224|Proteobacteria,2W0UV@28216|Betaproteobacteria,3T7CD@506|Alcaligenaceae 28216|Betaproteobacteria E Branched-chain amino acid transport system / permease component - - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_261452_1 1005048.CFU_2017 3.21e-40 146.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VHYG@28216|Betaproteobacteria,472H2@75682|Oxalobacteraceae 28216|Betaproteobacteria H Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR). Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate frc - 2.8.3.16 ko:K07749 - - - - ko00000,ko01000 - - - CoA_transf_3 k59_261452_2 1279038.KB907340_gene1471 1.6e-10 61.2 COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,2U19S@28211|Alphaproteobacteria,2JSGR@204441|Rhodospirillales 204441|Rhodospirillales Q Multicopper oxidase - - - - - - - - - - - - Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3 k59_1199787_1 247639.MGP2080_13658 1.92e-34 132.0 COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,1RNB7@1236|Gammaproteobacteria 1236|Gammaproteobacteria S metal-dependent hydrolase with the TIM-barrel fold - - - - - - - - - - - - Amidohydro_3 k59_1073538_1 1121861.KB899938_gene4006 9.91e-70 225.0 COG0701@1|root,COG0701@2|Bacteria,1MUN8@1224|Proteobacteria,2TRU3@28211|Alphaproteobacteria,2JR3N@204441|Rhodospirillales 204441|Rhodospirillales S Predicted permease - - - - - - - - - - - - ArsP_1 k59_348177_1 1000565.METUNv1_02893 2.03e-169 488.0 COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,2VJ3W@28216|Betaproteobacteria,2KUVT@206389|Rhodocyclales 206389|Rhodocyclales U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components ffh - 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB k59_730920_1 1163617.SCD_n02929 6.37e-110 329.0 COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,2VHK9@28216|Betaproteobacteria 28216|Betaproteobacteria H Aminotransferase hemL - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_858104_1 543913.D521_1110 1.2e-09 55.5 COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,2VSHX@28216|Betaproteobacteria,1KQ50@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria O Thioredoxin-like domain trxA - - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin k59_858104_2 715451.ambt_15865 2.04e-28 114.0 COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,1RP95@1236|Gammaproteobacteria,464AJ@72275|Alteromonadaceae 1236|Gammaproteobacteria K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template rho GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576 - ko:K03628 ko03018,map03018 - - - ko00000,ko00001,ko03019,ko03021 - - - ATP-synt_ab,Rho_N,Rho_RNA_bind k59_389581_1 1123236.KB899393_gene3201 2.52e-09 63.2 COG0642@1|root,COG0642@2|Bacteria,1QU3Z@1224|Proteobacteria,1T311@1236|Gammaproteobacteria,46D2F@72275|Alteromonadaceae 1236|Gammaproteobacteria T Histidine kinase - - - - - - - - - - - - CBM9_1,HATPase_c,HisKA k59_389581_2 1121861.KB899921_gene3055 5.97e-07 50.1 COG0745@1|root,COG0745@2|Bacteria,1MVCB@1224|Proteobacteria,2TR43@28211|Alphaproteobacteria,2JQU8@204441|Rhodospirillales 204441|Rhodospirillales T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain chvI - - ko:K14981 ko02020,map02020 M00520 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_559886_1 1117315.AHCA01000015_gene1685 8.76e-41 147.0 COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,1RMYA@1236|Gammaproteobacteria,2PZIQ@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF GO:0003674,GO:0003824,GO:0004044,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006164,GO:0006520,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009064,GO:0009117,GO:0009165,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019637,GO:0019752,GO:0034641,GO:0034654,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - iAF1260.b2312,iB21_1397.B21_02197,iBWG_1329.BWG_2086,iECBD_1354.ECBD_1347,iECB_1328.ECB_02237,iECDH10B_1368.ECDH10B_2474,iECDH1ME8569_1439.ECDH1ME8569_2250,iECD_1391.ECD_02237,iECIAI1_1343.ECIAI1_2389,iECO103_1326.ECO103_2776,iECO111_1330.ECO111_3060,iECO26_1355.ECO26_3300,iECW_1372.ECW_m2501,iEKO11_1354.EKO11_1453,iETEC_1333.ETEC_2448,iEcDH1_1363.EcDH1_1344,iEcE24377_1341.EcE24377A_2606,iEcolC_1368.EcolC_1340,iJO1366.b2312,iJR904.b2312,iSF_1195.SF2388,iSFxv_1172.SFxv_2633,iSSON_1240.SSON_2370,iS_1188.S2523,iSbBS512_1146.SbBS512_E2690,iUMNK88_1353.UMNK88_2863,iWFL_1372.ECW_m2501,iY75_1357.Y75_RS12125 GATase_6,Pribosyltran k59_559886_2 1163407.UU7_02727 8.69e-11 62.8 COG1286@1|root,COG1286@2|Bacteria,1NF4G@1224|Proteobacteria,1RQ58@1236|Gammaproteobacteria,1X6XU@135614|Xanthomonadales 135614|Xanthomonadales S membrane protein, required for colicin V production - - - ko:K03558 - - - - ko00000 - - - Colicin_V k59_261540_1 289376.THEYE_A1890 1.3e-36 141.0 COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,3J0XC@40117|Nitrospirae 40117|Nitrospirae T Adenylate cyclase - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CHASE2,Guanylate_cyc k59_1284928_2 1163617.SCD_n00812 2.38e-52 177.0 COG0795@1|root,COG0795@2|Bacteria,1MUF2@1224|Proteobacteria,2VH9C@28216|Betaproteobacteria 28216|Betaproteobacteria S Permease, YjgP YjgQ family lptF - - ko:K07091 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_348296_1 1210884.HG799475_gene15307 7.03e-107 328.0 COG3464@1|root,COG3464@2|Bacteria,2J105@203682|Planctomycetes 203682|Planctomycetes L PFAM Transposase IS66 family - - - ko:K07484 - - - - ko00000 - - - DDE_Tnp_IS66,zf-IS66 k59_306462_1 411479.BACUNI_04135 2.94e-22 99.0 COG0530@1|root,COG0530@2|Bacteria,4NFBC@976|Bacteroidetes,2FNX9@200643|Bacteroidia,4ANFN@815|Bacteroidaceae 976|Bacteroidetes P K -dependent Na Ca exchanger yrbG - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex k59_604861_1 460265.Mnod_2965 1.84e-23 101.0 COG2070@1|root,COG2070@2|Bacteria,1MU2F@1224|Proteobacteria,2TUT7@28211|Alphaproteobacteria,1JSXA@119045|Methylobacteriaceae 28211|Alphaproteobacteria S PFAM 2-nitropropane dioxygenase NPD - - 1.13.12.16,1.3.1.9 ko:K00459,ko:K02371 ko00061,ko00910,ko01100,ko01212,map00061,map00910,map01100,map01212 M00083 R00025,R04429,R04724,R04955,R04958,R04961,R04966,R04969,R07765 RC00052,RC00076,RC02541,RC02759 ko00000,ko00001,ko00002,ko01000,ko01004 - - - NMO k59_688509_1 887898.HMPREF0551_1787 1.5e-91 280.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,2VHPE@28216|Betaproteobacteria,1K2EB@119060|Burkholderiaceae 28216|Betaproteobacteria U Type II secretion system pilC - - ko:K02653 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSF k59_688509_2 292.DM42_1264 7.76e-13 68.2 COG1989@1|root,COG1989@2|Bacteria,1MUZF@1224|Proteobacteria,2VI08@28216|Betaproteobacteria,1K2F5@119060|Burkholderiaceae 28216|Betaproteobacteria NOU Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue pilD - 3.4.23.43 ko:K02654 - M00331 - - ko00000,ko00002,ko01000,ko01002,ko02035,ko02044 3.A.15.2 - - DiS_P_DiS,Peptidase_A24 k59_306514_1 887062.HGR_08044 4.69e-98 302.0 COG0318@1|root,COG0318@2|Bacteria,1MUMC@1224|Proteobacteria,2VGZE@28216|Betaproteobacteria,4A9R2@80864|Comamonadaceae 28216|Betaproteobacteria IQ PFAM AMP-dependent synthetase and ligase alkK - 6.2.1.44 ko:K20034 ko00920,map00920 - R10820 RC00004,RC00014 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C k59_731083_1 1038869.AXAN01000006_gene988 2.07e-39 150.0 COG0665@1|root,COG4121@1|root,COG0665@2|Bacteria,COG4121@2|Bacteria,1MZW5@1224|Proteobacteria,2VHGY@28216|Betaproteobacteria,1K1MC@119060|Burkholderiaceae 28216|Betaproteobacteria J Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 mnmC - 2.1.1.61 ko:K15461 - - R00601,R08702 RC00003,RC00053,RC00060,RC01483 ko00000,ko01000,ko03016 - - - DAO,Methyltransf_30 k59_8230_1 377629.TERTU_0902 6.15e-143 416.0 COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,1RMR4@1236|Gammaproteobacteria,2PMK0@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria C NAD(P) transhydrogenase beta subunit pntB - 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB k59_688521_2 159087.Daro_4053 1.1e-26 112.0 COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,2VH9R@28216|Betaproteobacteria,2KUUQ@206389|Rhodocyclales 206389|Rhodocyclales U Involved in the tonB-independent uptake of proteins tolB - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40,TolB_N k59_604893_1 1379698.RBG1_1C00001G1780 1.27e-15 73.6 COG0826@1|root,COG0826@2|Bacteria,2NS1M@2323|unclassified Bacteria 2|Bacteria O peptidase U32 yegQ GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K08303 ko05120,map05120 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_U32,Peptidase_U32_C k59_604893_2 391038.Bphy_2487 9.04e-11 62.4 COG0150@1|root,COG0150@2|Bacteria,1MURG@1224|Proteobacteria,2VHJT@28216|Betaproteobacteria,1K2VU@119060|Burkholderiaceae 28216|Betaproteobacteria F Phosphoribosylformylglycinamidine cyclo-ligase purM - 6.3.3.1 ko:K01933 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04208 RC01100 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k59_348399_1 1392838.AWNM01000016_gene3237 4.42e-87 272.0 COG0155@1|root,COG0155@2|Bacteria,1MVVB@1224|Proteobacteria,2VIYX@28216|Betaproteobacteria,3T1UQ@506|Alcaligenaceae 28216|Betaproteobacteria C Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate cysI - 1.8.1.2,1.8.7.1 ko:K00381,ko:K00392 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R00858,R00859,R03600 RC00065 ko00000,ko00001,ko00002,ko01000 - - - NIR_SIR,NIR_SIR_ferr k59_8245_1 326427.Cagg_3400 9.72e-88 273.0 COG0154@1|root,COG0154@2|Bacteria,2G7WJ@200795|Chloroflexi,3771Y@32061|Chloroflexia 32061|Chloroflexia J Belongs to the amidase family - - 3.5.1.4 ko:K01426 ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120 - R02540,R03096,R03180,R03909,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000 - - - Amidase k59_475387_1 316057.RPD_4078 4.66e-89 271.0 COG0111@1|root,COG0111@2|Bacteria,1MW0R@1224|Proteobacteria,2TWC9@28211|Alphaproteobacteria,3JVP3@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria EH D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain - - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C k59_1285051_1 762376.AXYL_03319 3.63e-48 161.0 COG0395@1|root,COG0395@2|Bacteria,1MUWS@1224|Proteobacteria,2VICF@28216|Betaproteobacteria,3T1RD@506|Alcaligenaceae 28216|Betaproteobacteria G probably responsible for the translocation of the substrate across the membrane ugpE - - ko:K05815 ko02010,map02010 M00198 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.3 - - BPD_transp_1 k59_1285051_2 1205680.CAKO01000042_gene5360 4.84e-90 273.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQQJ@28211|Alphaproteobacteria,2JQRA@204441|Rhodospirillales 204441|Rhodospirillales E Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system ugpC - 3.6.3.20 ko:K05816 ko02010,map02010 M00198 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.1.3 - - ABC_tran,TOBE_2 k59_348456_1 883126.HMPREF9710_04767 3.39e-07 54.3 COG2170@1|root,COG2170@2|Bacteria,1MX4N@1224|Proteobacteria,2VK27@28216|Betaproteobacteria,47394@75682|Oxalobacteraceae 28216|Betaproteobacteria H ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity ybdK - - ko:K06048 - - - - ko00000,ko01000 - - - GCS2 k59_348456_2 1454004.AW11_02848 2.28e-32 117.0 COG1863@1|root,COG1863@2|Bacteria,1MZYJ@1224|Proteobacteria 1224|Proteobacteria P COG1863 Multisubunit Na H antiporter MnhE subunit mnhE - - ko:K05569 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - MNHE k59_774771_1 113395.AXAI01000005_gene3808 2.88e-45 150.0 COG0824@1|root,COG0824@2|Bacteria,1N8J9@1224|Proteobacteria,2UHEA@28211|Alphaproteobacteria,3JY8Z@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Thioesterase-like superfamily - - - ko:K07107 - - - - ko00000,ko01000 - - - 4HBT,4HBT_2 k59_774771_2 1235457.C404_19620 4.6e-32 121.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2VH4C@28216|Betaproteobacteria,1JZW5@119060|Burkholderiaceae 28216|Betaproteobacteria I Belongs to the thiolase family - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_1328916_1 477974.Daud_0118 3.58e-64 214.0 COG2759@1|root,COG2759@2|Bacteria,1TP6N@1239|Firmicutes,247P5@186801|Clostridia,2601Q@186807|Peptococcaceae 186801|Clostridia F Belongs to the formate--tetrahydrofolate ligase family fhs - 6.3.4.3 ko:K01938 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R00943 RC00026,RC00111 ko00000,ko00001,ko00002,ko01000 - - - FTHFS k59_1200092_1 1123487.KB892836_gene3222 1.65e-54 194.0 COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,2VHHQ@28216|Betaproteobacteria,2KU7T@206389|Rhodocyclales 206389|Rhodocyclales Q ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX k59_986963_1 1122604.JONR01000050_gene3118 2.18e-84 263.0 COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,1RN91@1236|Gammaproteobacteria,1X48Z@135614|Xanthomonadales 135614|Xanthomonadales M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine murA - 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R00660 RC00350 ko00000,ko00001,ko01000,ko01011 - - - EPSP_synthase k59_986963_2 1122619.KB892368_gene2405 1.36e-06 46.6 COG5007@1|root,COG5007@2|Bacteria,1MZCZ@1224|Proteobacteria,2VU0K@28216|Betaproteobacteria,3T4IC@506|Alcaligenaceae 28216|Betaproteobacteria K Belongs to the BolA IbaG family yrbA - - - - - - - - - - - BolA k59_645813_1 1502851.FG93_00182 1.46e-45 168.0 COG0642@1|root,COG2203@1|root,COG5002@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,2TX3Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Histidine kinase-like ATPases - - - - - - - - - - - - GAF,GAF_2,HAMP,HATPase_c,HisKA,Hpt,Response_reg,dCache_1 k59_389845_1 1123393.KB891316_gene1786 5.52e-114 342.0 COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,2VJ5M@28216|Betaproteobacteria,1KS2N@119069|Hydrogenophilales 119069|Hydrogenophilales E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate proA - 1.2.1.41 ko:K00147 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 M00015 R03313 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_815620_1 1121035.AUCH01000025_gene3338 1.01e-38 138.0 COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,2VHUC@28216|Betaproteobacteria,2KV2M@206389|Rhodocyclales 206389|Rhodocyclales L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_int_SAM_4,Phage_integrase k59_815620_2 635013.TherJR_1461 1.47e-48 167.0 COG0517@1|root,COG0517@2|Bacteria,1TQ4J@1239|Firmicutes,24B68@186801|Clostridia,260BK@186807|Peptococcaceae 186801|Clostridia S Transposase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_389859_1 261292.Nit79A3_2503 1.59e-32 127.0 COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2VK9J@28216|Betaproteobacteria 28216|Betaproteobacteria L PFAM transposase, IS4 family protein - - - - - - - - - - - - DDE_Tnp_1,DUF772 k59_605025_1 1198232.CYCME_0743 4.7e-145 417.0 COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,1RMYX@1236|Gammaproteobacteria,45ZSW@72273|Thiotrichales 72273|Thiotrichales J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 k59_432956_1 203122.Sde_0988 3.29e-79 256.0 COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,1RP6F@1236|Gammaproteobacteria,464CN@72275|Alteromonadaceae 1236|Gammaproteobacteria G Belongs to the glycosyl hydrolase 13 family glgX - 3.2.1.41,3.2.1.68 ko:K01200,ko:K01214 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02111,R09995,R11261 - ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48 k59_348528_1 864051.BurJ1DRAFT_4168 6.96e-84 256.0 COG3245@1|root,COG3245@2|Bacteria,1RCEB@1224|Proteobacteria,2VQIB@28216|Betaproteobacteria,1KNAQ@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Cytochrome c554 and c-prime - - - - - - - - - - - - Cytochrome_C554,Cytochrome_CBB3 k59_1073903_1 1121957.ATVL01000010_gene200 2.04e-125 369.0 COG0156@1|root,COG0156@2|Bacteria,4NFBU@976|Bacteroidetes,47MGP@768503|Cytophagia 976|Bacteroidetes H Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA kbl - 2.3.1.29 ko:K00639 ko00260,map00260 - R00371 RC00004,RC00394 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_1114048_1 1454004.AW11_03587 7.73e-98 292.0 COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,2VI81@28216|Betaproteobacteria,1KPRK@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria V ATP-binding protein ybhF_1 - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1157526_1 479432.Sros_5643 7.29e-22 96.7 COG2141@1|root,COG2141@2|Bacteria,2GJTP@201174|Actinobacteria,4EJ3D@85012|Streptosporangiales 201174|Actinobacteria C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_1073912_1 1207063.P24_06751 2.11e-55 182.0 COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,2TSUR@28211|Alphaproteobacteria,2JPQ8@204441|Rhodospirillales 204441|Rhodospirillales V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin uppP - 3.6.1.27 ko:K06153 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - BacA k59_560130_1 420662.Mpe_B0539 4.4e-235 657.0 COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,2VI46@28216|Betaproteobacteria,1KJ6S@119065|unclassified Burkholderiales 28216|Betaproteobacteria H Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) - - 6.2.1.30 ko:K01912 ko00360,ko01120,ko05111,map00360,map01120,map05111 - R02539 RC00004,RC00014 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C_2 k59_1114099_1 671143.DAMO_1287 7.21e-65 211.0 COG2801@1|root,COG2801@2|Bacteria,2NQ4I@2323|unclassified Bacteria 2|Bacteria L Homeodomain-like domain - - - ko:K07497 - - - - ko00000 - - - HTH_28,HTH_32,LZ_Tnp_IS481,rve,rve_3 k59_731294_1 305700.B447_05955 5.32e-67 219.0 COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,2VIBV@28216|Betaproteobacteria,2KVEJ@206389|Rhodocyclales 206389|Rhodocyclales T Histidine kinase phoR - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - DUF3329,HATPase_c,HisKA,PAS_8 k59_716097_2 1123504.JQKD01000002_gene3754 2.7e-48 168.0 COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,2VKJ8@28216|Betaproteobacteria,4AD1S@80864|Comamonadaceae 28216|Betaproteobacteria KLT Protein tyrosine kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase k59_805393_1 153948.NAL212_0709 5.31e-42 147.0 COG0150@1|root,COG0150@2|Bacteria,1MURG@1224|Proteobacteria,2VHJT@28216|Betaproteobacteria,372FX@32003|Nitrosomonadales 28216|Betaproteobacteria F Phosphoribosylformylglycinamidine cyclo-ligase purM - 6.3.3.1 ko:K01933 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04208 RC01100 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k59_805393_2 497321.C664_13664 3.88e-61 203.0 COG0628@1|root,COG0628@2|Bacteria,1MW0B@1224|Proteobacteria,2VHDW@28216|Betaproteobacteria,2KUGY@206389|Rhodocyclales 206389|Rhodocyclales S Pfam:UPF0118 - - - - - - - - - - - - AI-2E_transport k59_503040_1 106648.BBLJ01000021_gene3088 4.61e-13 73.9 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,1RNE4@1236|Gammaproteobacteria,3NIPA@468|Moraxellaceae 1236|Gammaproteobacteria P Acts as a magnesium transporter mgtE - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_758690_1 1150469.RSPPHO_00684 1.71e-60 201.0 COG0491@1|root,COG0491@2|Bacteria,1MUXF@1224|Proteobacteria,2TSYY@28211|Alphaproteobacteria,2JQ8A@204441|Rhodospirillales 204441|Rhodospirillales S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_335989_1 292415.Tbd_2692 2.51e-25 101.0 COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,2VHSA@28216|Betaproteobacteria,1KT04@119069|Hydrogenophilales 119069|Hydrogenophilales V Bacitracin resistance protein BacA - - 3.6.1.27 ko:K06153 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - BacA k59_335989_2 1137799.GZ78_02845 9.42e-22 93.2 COG1073@1|root,COG1073@2|Bacteria,1RIWI@1224|Proteobacteria,1S6JM@1236|Gammaproteobacteria,1XMHV@135619|Oceanospirillales 135619|Oceanospirillales S Serine aminopeptidase, S33 - - - ko:K06889 - - - - ko00000 - - - Hydrolase_4 k59_287626_1 99598.Cal7507_5584 1.86e-48 166.0 COG0825@1|root,COG0825@2|Bacteria,1G0PY@1117|Cyanobacteria,1HJ7R@1161|Nostocales 1117|Cyanobacteria I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA accA - 2.1.3.15,6.4.1.2 ko:K01962 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - ACCA k59_247826_1 1049564.TevJSym_ax00490 1.68e-39 150.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1J5F8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran k59_586002_1 404589.Anae109_2990 2.69e-20 87.0 COG2963@1|root,COG2963@2|Bacteria,1N1MP@1224|Proteobacteria,43BIX@68525|delta/epsilon subdivisions,2X6XD@28221|Deltaproteobacteria,2YVUT@29|Myxococcales 28221|Deltaproteobacteria L COG2801 Transposase and inactivated derivatives - - - - - - - - - - - - HTH_28,HTH_Tnp_1 k59_293308_2 398578.Daci_2145 3.62e-54 174.0 COG0537@1|root,COG0537@2|Bacteria,1N422@1224|Proteobacteria,2VT5W@28216|Betaproteobacteria,4ADM7@80864|Comamonadaceae 28216|Betaproteobacteria FG Histidine triad (Hit) protein - - - ko:K02503 - - - - ko00000,ko04147 - - - HIT k59_466255_1 292415.Tbd_0723 7.96e-28 116.0 COG0672@1|root,COG2010@1|root,COG0672@2|Bacteria,COG2010@2|Bacteria,1MXHM@1224|Proteobacteria,2VIUK@28216|Betaproteobacteria 28216|Betaproteobacteria P Iron permease FTR1 - - - ko:K07243 - - - - ko00000,ko02000 2.A.108.1,2.A.108.2 - - Cytochrom_C,FTR1 k59_466286_1 360910.BAV2394 7.36e-33 129.0 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,2VK2H@28216|Betaproteobacteria,3T21G@506|Alcaligenaceae 28216|Betaproteobacteria J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,IF-2,IF2_N,IF2_assoc k59_466286_2 1454004.AW11_01897 2.8e-181 520.0 COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,2VH2X@28216|Betaproteobacteria,1KPUU@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria K Participates in both transcription termination and antitermination nusA - - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - HHH_5,KH_5,NusA_N,S1 k59_253472_1 395494.Galf_0272 1.1e-74 238.0 COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,2VJ1F@28216|Betaproteobacteria,44V78@713636|Nitrosomonadales 28216|Betaproteobacteria H Belongs to the anaerobic coproporphyrinogen-III oxidase family hemN GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0051989,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - - - - - - - - - - HemN_C,Radical_SAM k59_253472_2 1298865.H978DRAFT_1503 2.31e-05 47.0 COG2836@1|root,COG2836@2|Bacteria,1RIGJ@1224|Proteobacteria,1S5V1@1236|Gammaproteobacteria,466TY@72275|Alteromonadaceae 1236|Gammaproteobacteria S Cytochrome C biogenesis protein transmembrane region braZ - - ko:K09792 - - - - ko00000 - - - DsbD_2 k59_165281_1 1122970.AUHC01000008_gene70 7.04e-15 74.3 COG0712@1|root,COG0712@2|Bacteria,1MVRH@1224|Proteobacteria,2U5IC@28211|Alphaproteobacteria,2K4UU@204457|Sphingomonadales 204457|Sphingomonadales C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpH - - ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - OSCP k59_165281_2 264732.Moth_2380 1.22e-10 61.6 COG0056@1|root,COG0056@2|Bacteria,1TNZ8@1239|Firmicutes,248IY@186801|Clostridia,42F4E@68295|Thermoanaerobacterales 186801|Clostridia C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_721913_1 1121015.N789_13870 5.36e-39 149.0 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,1RP9N@1236|Gammaproteobacteria,1X38Z@135614|Xanthomonadales 135614|Xanthomonadales H Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell glnE GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006521,GO:0008150,GO:0008882,GO:0010565,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0031323,GO:0033238,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0070566,GO:0080090 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_1276254_1 228410.NE1614 1.05e-106 320.0 COG0617@1|root,COG0617@2|Bacteria,1MU2X@1224|Proteobacteria,2VIN5@28216|Betaproteobacteria,371UT@32003|Nitrosomonadales 28216|Betaproteobacteria J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'- nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases cca - 2.7.7.72 ko:K00974 ko03013,map03013 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016 - - - HD,PolyA_pol,PolyA_pol_RNAbd k59_210266_1 1232410.KI421421_gene3270 1.52e-124 367.0 COG1775@1|root,COG1775@2|Bacteria,1NNW9@1224|Proteobacteria,42RTN@68525|delta/epsilon subdivisions,2WNYI@28221|Deltaproteobacteria,43V0Q@69541|Desulfuromonadales 28221|Deltaproteobacteria E 2-hydroxyglutaryl-CoA dehydratase, D-component - - 1.3.7.8 ko:K04112 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00541 R02451 RC00002,RC01839 ko00000,ko00001,ko00002,ko01000 - - - HGD-D k59_466383_1 551275.KB899546_gene2015 4.49e-51 183.0 COG1629@1|root,COG4771@2|Bacteria,1N6JG@1224|Proteobacteria,2TSK9@28211|Alphaproteobacteria,43WCB@69657|Hyphomonadaceae 28211|Alphaproteobacteria P Outer membrane receptor - - - - - - - - - - - - CarboxypepD_reg,Plug,TonB_dep_Rec k59_165446_1 323848.Nmul_A0442 2.54e-77 245.0 COG3705@1|root,COG3705@2|Bacteria,1MWIG@1224|Proteobacteria,2VHVX@28216|Betaproteobacteria,372G2@32003|Nitrosomonadales 28216|Betaproteobacteria E Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine hisZ - - ko:K02502 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002 - - - tRNA-synt_His k59_165446_2 292415.Tbd_0607 1.06e-73 233.0 COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,2VHBR@28216|Betaproteobacteria,1KRBE@119069|Hydrogenophilales 119069|Hydrogenophilales F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP purA - 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 - - - Adenylsucc_synt k59_764522_1 234267.Acid_0899 3.67e-10 68.2 COG4219@1|root,COG4219@2|Bacteria,3Y4QS@57723|Acidobacteria 2|Bacteria KT Peptidase M56, BlaR1 - - - - - - - - - - - - Peptidase_M56,TonB_C k59_764522_2 886293.Sinac_6279 1.11e-31 115.0 COG3682@1|root,COG3682@2|Bacteria,2J0QT@203682|Planctomycetes 203682|Planctomycetes K Penicillinase repressor - - - - - - - - - - - - Penicillinase_R k59_1318965_1 365046.Rta_26250 1.63e-72 235.0 COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,2VH96@28216|Betaproteobacteria,4AAEM@80864|Comamonadaceae 28216|Betaproteobacteria Q copper-resistance protein, CopA family copA - - - - - - - - - - - Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3 k59_123365_1 58123.JOFJ01000012_gene5442 1.13e-40 148.0 COG4243@1|root,COG4243@2|Bacteria,2HG56@201174|Actinobacteria,4EQMU@85012|Streptosporangiales 201174|Actinobacteria S Vitamin k epoxide reductase - - - - - - - - - - - - - k59_424570_1 1123504.JQKD01000003_gene638 5.85e-28 111.0 COG0179@1|root,COG0179@2|Bacteria,1MW82@1224|Proteobacteria,2VJAE@28216|Betaproteobacteria,4ACVI@80864|Comamonadaceae 28216|Betaproteobacteria Q fumarylacetoacetate (FAA) hydrolase - - 3.7.1.2 ko:K01555 ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120 M00044 R01364 RC00326,RC00446 ko00000,ko00001,ko00002,ko01000,ko04147 - - - FAA_hydrolase,FAA_hydrolase_N k59_424615_1 572477.Alvin_0339 2.64e-65 212.0 COG1055@1|root,COG1055@2|Bacteria,1NEVR@1224|Proteobacteria,1RQVD@1236|Gammaproteobacteria,1WXGB@135613|Chromatiales 135613|Chromatiales P Citrate transporter - - - - - - - - - - - - CitMHS k59_1234120_1 1121035.AUCH01000017_gene2280 5.62e-18 80.5 COG2078@1|root,COG2078@2|Bacteria,1RJP4@1224|Proteobacteria,2VRE4@28216|Betaproteobacteria,2KWM9@206389|Rhodocyclales 206389|Rhodocyclales S AMMECR1 - - - - - - - - - - - - AMMECR1 k59_1234120_2 159087.Daro_1969 4.71e-101 302.0 COG1180@1|root,COG1180@2|Bacteria,1NQC1@1224|Proteobacteria,2VINV@28216|Betaproteobacteria,2KU6E@206389|Rhodocyclales 206389|Rhodocyclales C Radical SAM superfamily pflA - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Fer4_12,Radical_SAM k59_887750_1 1121015.N789_13630 9.74e-84 265.0 COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,1RMVN@1236|Gammaproteobacteria,1X43R@135614|Xanthomonadales 135614|Xanthomonadales M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS k59_680267_1 1096546.WYO_4502 2.22e-18 88.6 COG3391@1|root,COG3391@2|Bacteria,1MXRF@1224|Proteobacteria,2U1E9@28211|Alphaproteobacteria,1JZA3@119045|Methylobacteriaceae 28211|Alphaproteobacteria S amine dehydrogenase activity - - - - - - - - - - - - NHL k59_722298_2 331869.BAL199_23649 3.1e-32 123.0 COG0795@1|root,COG0795@2|Bacteria,1MVW3@1224|Proteobacteria,2TR76@28211|Alphaproteobacteria,4BQ5H@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Predicted permease YjgP/YjgQ family lptG - - ko:K11720 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_1143032_1 83406.HDN1F_06220 6.94e-48 169.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMIW@1236|Gammaproteobacteria,1J5GF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J COG1530 Ribonucleases G and E rng GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005856,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008996,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360 - ko:K08301 - - - - ko00000,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_722310_1 391038.Bphy_0459 1.79e-104 315.0 COG0126@1|root,COG0126@2|Bacteria,1MUNU@1224|Proteobacteria,2VHJK@28216|Betaproteobacteria,1K22I@119060|Burkholderiaceae 28216|Betaproteobacteria G Belongs to the phosphoglycerate kinase family pgk GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.2.3 ko:K00927 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01512 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGK k59_1276672_1 1366050.N234_25040 7.15e-48 169.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VJ5E@28216|Betaproteobacteria,1K0Z0@119060|Burkholderiaceae 28216|Betaproteobacteria I PFAM AMP-dependent synthetase and ligase - - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_293865_1 1342299.Z947_3849 4.76e-128 369.0 COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,2TRHP@28211|Alphaproteobacteria,3ZUZU@60136|Sulfitobacter 28211|Alphaproteobacteria F Belongs to the ATCase OTCase family pyrB GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_977974_1 765912.Thimo_2131 1.06e-26 103.0 COG0806@1|root,COG0806@2|Bacteria,1MWQR@1224|Proteobacteria,1RNJ2@1236|Gammaproteobacteria,1WY0M@135613|Chromatiales 135613|Chromatiales J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes rimM - - ko:K02860 - - - - ko00000,ko03009 - - - PRC,RimM k59_977974_2 1089439.KB902271_gene1989 2.31e-25 96.3 COG0228@1|root,COG0228@2|Bacteria,1MZCT@1224|Proteobacteria,1S8RT@1236|Gammaproteobacteria,4618I@72273|Thiotrichales 72273|Thiotrichales J Belongs to the bacterial ribosomal protein bS16 family rpsP - - ko:K02959 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S16 k59_253975_1 1380394.JADL01000004_gene5933 5.76e-96 290.0 COG4177@1|root,COG4177@2|Bacteria,1PSHZ@1224|Proteobacteria,2TVQQ@28211|Alphaproteobacteria,2JVEV@204441|Rhodospirillales 204441|Rhodospirillales E Branched-chain amino acid transport system / permease component - - - - - - - - - - - - BPD_transp_2 k59_253975_2 1380394.JADL01000004_gene5934 2.18e-112 332.0 COG0559@1|root,COG0559@2|Bacteria,1R5JM@1224|Proteobacteria,2TUSY@28211|Alphaproteobacteria,2JVGR@204441|Rhodospirillales 204441|Rhodospirillales E Branched-chain amino acid transport system / permease component - - - - - - - - - - - - BPD_transp_2 k59_935795_1 272630.MexAM1_META1p0291 7.4e-07 56.2 COG0596@1|root,COG0596@2|Bacteria,1MW2P@1224|Proteobacteria,2TSS3@28211|Alphaproteobacteria,1JS3B@119045|Methylobacteriaceae 28211|Alphaproteobacteria S PFAM alpha beta hydrolase fold MA20_32265 - 1.11.1.10 ko:K00433 - - - - ko00000,ko01000 - - - Abhydrolase_1 k59_935795_2 717772.THIAE_02395 8.65e-18 82.0 COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,1RMAT@1236|Gammaproteobacteria,46040@72273|Thiotrichales 72273|Thiotrichales H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives lipA - 2.8.1.8 ko:K03644 ko00785,ko01100,map00785,map01100 - R07767,R07768 RC01978 ko00000,ko00001,ko01000 - - - LIAS_N,Radical_SAM k59_978038_1 204773.HEAR2479 4.25e-28 114.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2VI60@28216|Betaproteobacteria,473N1@75682|Oxalobacteraceae 28216|Betaproteobacteria M Gamma-glutamyltranspeptidase ggt - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_978038_2 1122201.AUAZ01000019_gene1807 3.93e-11 66.6 COG2831@1|root,COG2831@2|Bacteria,1MWEC@1224|Proteobacteria,1RYVX@1236|Gammaproteobacteria,466E3@72275|Alteromonadaceae 1236|Gammaproteobacteria U Haemolysin secretion/activation protein ShlB/FhaC/HecB - - - - - - - - - - - - POTRA_2,ShlB k59_424797_1 1163617.SCD_n02483 1.36e-73 232.0 COG0812@1|root,COG0812@2|Bacteria,1MXDH@1224|Proteobacteria,2VI7I@28216|Betaproteobacteria 28216|Betaproteobacteria M cell wall formation murB - 1.3.1.98 ko:K00075 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R03191,R03192 RC02639 ko00000,ko00001,ko01000,ko01011 - - - FAD_binding_4,MurB_C k59_123611_1 1000565.METUNv1_02451 2.48e-119 373.0 COG0515@1|root,COG4252@1|root,COG0515@2|Bacteria,COG4252@2|Bacteria,1MV1P@1224|Proteobacteria,2VKJ8@28216|Betaproteobacteria,2KV51@206389|Rhodocyclales 206389|Rhodocyclales KLT Protein tyrosine kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - CHASE2,Pkinase k59_978047_1 1163407.UU7_07218 0.00021 49.7 COG3291@1|root,COG4934@1|root,COG3291@2|Bacteria,COG4934@2|Bacteria,1R98B@1224|Proteobacteria,1SN5E@1236|Gammaproteobacteria,1X58I@135614|Xanthomonadales 135614|Xanthomonadales O Pro-kumamolisin, activation domain - - 3.4.21.101 ko:K05999 - - - - ko00000,ko01000,ko01002 - - - PKD,PPC,Peptidase_S8,Pro-kuma_activ k59_466908_2 765911.Thivi_2107 1.93e-10 59.3 COG0745@1|root,COG0745@2|Bacteria,1RHCU@1224|Proteobacteria,1S571@1236|Gammaproteobacteria,1WYBC@135613|Chromatiales 135613|Chromatiales KT response regulator receiver - - - - - - - - - - - - Response_reg k59_1319303_1 305700.B447_11502 2.43e-65 204.0 COG1763@1|root,COG1763@2|Bacteria,1RD3Q@1224|Proteobacteria,2VSIP@28216|Betaproteobacteria,2KXR4@206389|Rhodocyclales 206389|Rhodocyclales H molybdopterin-guanine dinucleotide biosynthesis protein - - - ko:K03753 - - - - ko00000 - - - MobB k59_1319303_2 1134474.O59_004052 1.01e-07 52.4 COG0730@1|root,COG0730@2|Bacteria,1RD5A@1224|Proteobacteria,1S6M1@1236|Gammaproteobacteria 1236|Gammaproteobacteria S membrane transporter protein - - - - - - - - - - - - TauE k59_466919_1 498211.CJA_3399 8.06e-58 194.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1FFRG@10|Cellvibrio 1236|Gammaproteobacteria T Bacterial regulatory protein, Fis family prsR - - ko:K02481 - - - - ko00000,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_424894_2 570967.JMLV01000003_gene2298 1.38e-83 268.0 COG2223@1|root,COG2223@2|Bacteria,1QU99@1224|Proteobacteria,2TW9H@28211|Alphaproteobacteria,2JYYS@204441|Rhodospirillales 204441|Rhodospirillales P Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_424906_1 1298858.AUEL01000001_gene4851 2.21e-07 53.9 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQPG@28211|Alphaproteobacteria,43GYR@69277|Phyllobacteriaceae 28211|Alphaproteobacteria T CheY-like receiver AAA-type ATPase and DNA-binding domains - - - ko:K10126 ko02020,map02020 M00504 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_424906_2 221288.JH992901_gene3480 1.41e-35 138.0 COG0642@1|root,COG5000@1|root,COG2205@2|Bacteria,COG5000@2|Bacteria,1G09B@1117|Cyanobacteria,1JHSG@1189|Stigonemataceae 1117|Cyanobacteria T Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - - - - - - - - - - HATPase_c,HisKA,PAS_3,Response_reg k59_978175_1 1121920.AUAU01000010_gene61 3.24e-116 338.0 COG0500@1|root,COG2226@2|Bacteria,3Y5HG@57723|Acidobacteria 57723|Acidobacteria Q Mycolic acid cyclopropane synthetase - - - - - - - - - - - - Methyltransf_11 k59_888025_1 570967.JMLV01000002_gene1550 1.38e-43 154.0 COG3243@1|root,COG3243@2|Bacteria,1Q6YK@1224|Proteobacteria,2TTVK@28211|Alphaproteobacteria,2JQPE@204441|Rhodospirillales 204441|Rhodospirillales I alpha/beta hydrolase fold - - - ko:K03821 ko00650,map00650 - R04254 RC00004 ko00000,ko00001,ko01000 - - - Abhydrolase_1,PhaC_N k59_294102_1 1049564.TevJSym_ac00580 2.96e-71 237.0 COG2010@1|root,COG2010@2|Bacteria,1R28S@1224|Proteobacteria,1T5JD@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Cytochrome c - - - - - - - - - - - - Cytochrome_CBB3 k59_935993_1 1528106.JRJE01000031_gene3499 1.17e-100 306.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQPG@28211|Alphaproteobacteria,2JPK4@204441|Rhodospirillales 204441|Rhodospirillales T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains ntrC - - ko:K07712 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_1191648_1 644968.DFW101_2757 1.42e-120 366.0 COG1328@1|root,COG1328@2|Bacteria,1MWMS@1224|Proteobacteria,42M8V@68525|delta/epsilon subdivisions,2WJ7S@28221|Deltaproteobacteria,2MAFW@213115|Desulfovibrionales 28221|Deltaproteobacteria F ATP cone domain nrdD - 1.1.98.6 ko:K21636 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R11633,R11634,R11635,R11636 RC00613 ko00000,ko00001,ko00002,ko01000 - - - ATP-cone,NRDD k59_509550_1 76869.PputGB1_1820 4.77e-90 273.0 COG0010@1|root,COG0010@2|Bacteria,1MVFH@1224|Proteobacteria,1RMH5@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the arginase family speB GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008783,GO:0009058,GO:0009308,GO:0009309,GO:0009445,GO:0009446,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0030145,GO:0034641,GO:0042401,GO:0043167,GO:0043169,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576 3.5.3.11,3.5.3.7,3.5.3.8 ko:K01479,ko:K01480,ko:K12255 ko00330,ko00340,ko01100,map00330,map00340,map01100 M00045,M00133 R01157,R01990,R02285 RC00024,RC00221,RC00329,RC00681 ko00000,ko00001,ko00002,ko01000 - - iB21_1397.B21_02730,iECB_1328.ECB_02767,iECD_1391.ECD_02767,iSbBS512_1146.SbBS512_E3370 Arginase k59_166027_1 1502770.JQMG01000001_gene857 8.29e-32 127.0 COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,2VI5J@28216|Betaproteobacteria,2KMI1@206350|Nitrosomonadales 206350|Nitrosomonadales M PFAM AsmA family - - - ko:K07289 - - - - ko00000 - - - AsmA,AsmA_2 k59_166027_2 1336208.JADY01000014_gene1449 9.06e-06 47.0 COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,2TR5B@28211|Alphaproteobacteria,2JPY3@204441|Rhodospirillales 204441|Rhodospirillales S Psort location Cytoplasmic, score 7.50 - - - - - - - - - - - - M20_dimer,Peptidase_M20 k59_123855_1 1469245.JFBG01000034_gene1431 1.77e-42 159.0 COG0404@1|root,COG0446@1|root,COG0404@2|Bacteria,COG0446@2|Bacteria,1MVEK@1224|Proteobacteria,1RQKR@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the GcvT family - - 1.5.3.1 ko:K00302 ko00260,ko01100,map00260,map01100 - R00610 RC00060,RC00557 ko00000,ko00001,ko01000 - - - Fer2_4,GCV_T,GCV_T_C,Pyr_redox_2 k59_1234549_1 396588.Tgr7_0024 1.53e-46 160.0 COG0451@1|root,COG0451@2|Bacteria,1MWVJ@1224|Proteobacteria,1RNDT@1236|Gammaproteobacteria,1WW02@135613|Chromatiales 135613|Chromatiales GM PFAM NAD-dependent epimerase dehydratase - - - - - - - - - - - - Epimerase,NAD_binding_10,RmlD_sub_bind k59_552219_1 1432056.X781_23280 1.34e-53 184.0 COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,1RN5S@1236|Gammaproteobacteria,1Y7M6@135625|Pasteurellales 135625|Pasteurellales J Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 mnmE - - ko:K03650 - - R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 - - - MMR_HSR1,MnmE_helical,TrmE_N k59_765171_1 388051.AUFE01000071_gene3846 1.85e-126 370.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2VH4C@28216|Betaproteobacteria,1K39S@119060|Burkholderiaceae 28216|Betaproteobacteria I Belongs to the thiolase family phbA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_1234602_1 1117647.M5M_15045 8.86e-56 193.0 COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,1RQR7@1236|Gammaproteobacteria,1J5U9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria - - - ko:K21470 - - - - ko00000,ko01002,ko01011 - - - PG_binding_1,YkuD k59_680753_1 1502770.JQMG01000001_gene2324 1.59e-50 166.0 COG4969@1|root,COG4969@2|Bacteria,1N4MN@1224|Proteobacteria,2VVHM@28216|Betaproteobacteria,2KNTC@206350|Nitrosomonadales 206350|Nitrosomonadales NU Pilin (bacterial filament) - - - ko:K02650 ko02020,map02020 - - - ko00000,ko00001,ko02035,ko02044 3.A.15.2 - - N_methyl,Pilin k59_166172_1 375286.mma_3143 7.46e-12 63.5 COG1999@1|root,COG1999@2|Bacteria,1RHJ8@1224|Proteobacteria,2VR3M@28216|Betaproteobacteria,473BA@75682|Oxalobacteraceae 28216|Betaproteobacteria S Involved in biogenesis of respiratory and photosynthetic systems senC - - ko:K07152 - - - - ko00000,ko03029 - - - SCO1-SenC k59_166172_2 1123392.AQWL01000005_gene3151 3.18e-135 391.0 COG0484@1|root,COG0484@2|Bacteria,1MUZ4@1224|Proteobacteria,2VHMU@28216|Betaproteobacteria,1KRCW@119069|Hydrogenophilales 119069|Hydrogenophilales O DnaJ molecular chaperone homology domain - - - ko:K05516 - - - - ko00000,ko03036,ko03110 - - - DnaJ,DnaJ_C k59_211126_1 365046.Rta_23475 2.2e-26 108.0 COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,2VIBV@28216|Betaproteobacteria,4A9K8@80864|Comamonadaceae 28216|Betaproteobacteria T histidine kinase A domain protein phoR - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - DUF3329,HATPase_c,HisKA,PAS,PAS_8 k59_888229_1 584708.Apau_1119 1.13e-73 229.0 COG4336@1|root,COG4336@2|Bacteria,3T9Q8@508458|Synergistetes 508458|Synergistetes S Belongs to the D-glutamate cyclase family - - - - - - - - - - - - DUF1445 k59_278632_2 713587.THITH_08805 1.39e-47 168.0 COG4623@1|root,COG4623@2|Bacteria,1MWDS@1224|Proteobacteria,1RM8W@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella mltF2 GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 - ko:K18691 - - - - ko00000,ko01000,ko01011 - - - SBP_bac_3,SLT k59_707274_1 1038859.AXAU01000003_gene6200 1.13e-90 277.0 COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,2TSJQ@28211|Alphaproteobacteria,3JW7Q@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Branched-chain amino acid transport system / permease component - - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_108210_1 94122.Shewana3_2749 2.67e-97 295.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria,2Q9BN@267890|Shewanellaceae 1236|Gammaproteobacteria V PFAM ABC transporter related ybhF - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_967817_2 1122929.KB908221_gene2832 1.11e-25 102.0 COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2TT8N@28211|Alphaproteobacteria 28211|Alphaproteobacteria E branched-chain amino acid livF1 - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran k59_925454_1 926569.ANT_28990 1.21e-10 60.8 COG0448@1|root,COG0448@2|Bacteria,2G66Q@200795|Chloroflexi 200795|Chloroflexi H Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans glgC - 2.7.7.27 ko:K00975 ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026 M00565 R00948 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transferase k59_925454_2 1385420.FRA_17c00050 9.2e-39 134.0 COG3293@1|root,2ZJP3@2|Bacteria,1N918@1224|Proteobacteria,1T83V@1236|Gammaproteobacteria,463DF@72273|Thiotrichales 72273|Thiotrichales L Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - DDE_Tnp_4,HTH_Tnp_4 k59_32313_2 1288494.EBAPG3_28890 3.35e-46 161.0 COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,2VHXN@28216|Betaproteobacteria,371V8@32003|Nitrosomonadales 28216|Betaproteobacteria M Cell wall hydrolase autolysin amiC - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - AMIN,Amidase_3 k59_967829_1 1381123.AYOD01000015_gene2539 2.06e-39 140.0 COG0559@1|root,COG0559@2|Bacteria,1NQYP@1224|Proteobacteria,2TSH6@28211|Alphaproteobacteria,43HDY@69277|Phyllobacteriaceae 28211|Alphaproteobacteria E Branched-chain amino acid transport system / permease component MA20_07780 - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_967829_2 543728.Vapar_5382 3.42e-27 109.0 COG4638@1|root,COG4638@2|Bacteria,1N6MJ@1224|Proteobacteria,2VJ0B@28216|Betaproteobacteria,4AC5A@80864|Comamonadaceae 28216|Betaproteobacteria P Rieske 2Fe-2S domain protein - - - ko:K14748 ko00642,ko01100,ko01120,ko01220,map00642,map01100,map01120,map01220 - R05440 RC00098 br01602,ko00000,ko00001,ko01000 - - - Rieske,Ring_hydroxyl_A k59_283596_1 251221.35211453 1.69e-66 219.0 COG1174@1|root,COG1732@1|root,COG1174@2|Bacteria,COG1732@2|Bacteria,1G1ZS@1117|Cyanobacteria 1117|Cyanobacteria M Substrate binding domain of ABC-type glycine betaine transport system - - - ko:K05845,ko:K05846 ko02010,map02010 M00209 - - ko00000,ko00001,ko00002,ko02000 3.A.1.12 - - BPD_transp_1,OpuAC k59_283596_2 1532557.JL37_21140 6.85e-16 76.6 COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,2VJZN@28216|Betaproteobacteria,3T1Y4@506|Alcaligenaceae 28216|Betaproteobacteria C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane pntA - 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N,PNTB_4TM k59_1010193_1 909663.KI867150_gene1010 1.82e-21 98.6 2DBU2@1|root,2ZB3S@2|Bacteria,1N1MT@1224|Proteobacteria,42VJX@68525|delta/epsilon subdivisions,2WSPP@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - DDE_Tnp_1_4 k59_200543_1 1122603.ATVI01000006_gene251 1.76e-75 229.0 COG0242@1|root,COG0242@2|Bacteria,1R9XK@1224|Proteobacteria,1S2DI@1236|Gammaproteobacteria,1XBZM@135614|Xanthomonadales 135614|Xanthomonadales J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions - - - - - - - - - - - - Pep_deformylase k59_1102028_1 656519.Halsa_1392 1.5e-14 69.7 COG1722@1|root,COG1722@2|Bacteria,1VK9I@1239|Firmicutes,24UH5@186801|Clostridia,3WC6B@53433|Halanaerobiales 186801|Clostridia L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseB - 3.1.11.6 ko:K03602 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_S k59_541666_1 335283.Neut_2288 9.81e-34 119.0 COG2154@1|root,COG2154@2|Bacteria,1RH99@1224|Proteobacteria,2WFUX@28216|Betaproteobacteria 28216|Betaproteobacteria H pterin-4-alpha-carbinolamine dehydratase - - 4.2.1.96 ko:K01724 ko00790,map00790 - R04734 RC01208 ko00000,ko00001,ko01000,ko04147 - - - Pterin_4a k59_541666_2 1205680.CAKO01000029_gene4986 1.88e-34 128.0 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2TQN9@28211|Alphaproteobacteria,2JQE6@204441|Rhodospirillales 204441|Rhodospirillales E Pyridoxal-phosphate dependent enzyme - - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_113262_1 1123368.AUIS01000012_gene758 1.87e-70 233.0 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,1RNKN@1236|Gammaproteobacteria,2NCR4@225057|Acidithiobacillales 225057|Acidithiobacillales CP NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus - - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M,Proton_antipo_N k59_499113_1 1033736.CAHK01000031_gene1485 6.01e-41 147.0 COG0499@1|root,COG0499@2|Bacteria,2GK2Q@201174|Actinobacteria,4F95A@85019|Brevibacteriaceae 201174|Actinobacteria H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine ahcY GO:0000096,GO:0000098,GO:0000166,GO:0003674,GO:0003824,GO:0004013,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009066,GO:0009068,GO:0009069,GO:0009087,GO:0009116,GO:0009119,GO:0009987,GO:0016020,GO:0016054,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0019899,GO:0022610,GO:0030260,GO:0030312,GO:0033353,GO:0034641,GO:0035375,GO:0035635,GO:0036094,GO:0040007,GO:0042278,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044273,GO:0044281,GO:0044282,GO:0044403,GO:0044406,GO:0044409,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0044650,GO:0046085,GO:0046128,GO:0046395,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0048037,GO:0050662,GO:0051186,GO:0051287,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0055086,GO:0070403,GO:0071704,GO:0071944,GO:0072521,GO:0097159,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1901657 3.3.1.1 ko:K01251 ko00270,ko01100,map00270,map01100 M00035 R00192,R04936 RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko04147 - - - AdoHcyase,AdoHcyase_NAD k59_1059835_2 76114.ebA2092 1.05e-67 219.0 COG1703@1|root,COG1975@1|root,COG1703@2|Bacteria,COG1975@2|Bacteria,1MVI0@1224|Proteobacteria,2VIRF@28216|Betaproteobacteria,2KVDF@206389|Rhodocyclales 28216|Betaproteobacteria E periplasmic protein kinase ArgK and related GTPases of G3E family - - - ko:K07588 - - - - ko00000,ko01000 - - - ArgK k59_967907_1 1229780.BN381_130016 1.09e-59 192.0 COG0047@1|root,COG0047@2|Bacteria,2GMJY@201174|Actinobacteria,3UWG1@52018|unclassified Actinobacteria (class) 201174|Actinobacteria F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purQ GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044464,GO:0071944 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - GATase_5 k59_1223961_1 395495.Lcho_0462 3.53e-65 213.0 COG2907@1|root,COG2907@2|Bacteria,1MV4Z@1224|Proteobacteria,2VHCR@28216|Betaproteobacteria,1KK8T@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Flavin containing amine oxidoreductase - - - ko:K06954 - - - - ko00000 - - - Amino_oxidase,NAD_binding_8 k59_1223970_1 62928.azo0510 1.57e-68 220.0 COG0611@1|root,COG0611@2|Bacteria,1MU9X@1224|Proteobacteria,2VI0Q@28216|Betaproteobacteria,2KV5I@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 thiL - 2.7.4.16 ko:K00946 ko00730,ko01100,map00730,map01100 M00127 R00617 RC00002 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k59_879158_1 566466.NOR53_889 1.81e-70 225.0 COG2957@1|root,COG2957@2|Bacteria,1MX65@1224|Proteobacteria,1RMF1@1236|Gammaproteobacteria,1J4KW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E COG2957 Peptidylarginine deiminase and related enzymes aguA - 3.5.3.12 ko:K10536 ko00330,ko01100,map00330,map01100 - R01416 RC00177 ko00000,ko00001,ko01000 - - - PAD_porph k59_414690_1 1265503.KB905174_gene4306 9.5e-25 107.0 COG2303@1|root,COG2303@2|Bacteria,1MU3F@1224|Proteobacteria,1RPBQ@1236|Gammaproteobacteria,2Q6A8@267889|Colwelliaceae 1236|Gammaproteobacteria E GMC oxidoreductase - - 1.1.99.3 ko:K06151 ko00030,ko01100,ko01120,map00030,map01100,map01120 - R01741 RC00084 ko00000,ko00001,ko01000 - - - FAD_binding_2,GMC_oxred_C,GMC_oxred_N,NAD_binding_8 k59_113409_1 292415.Tbd_0118 4.13e-27 109.0 COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,2VI5Q@28216|Betaproteobacteria,1KS5G@119069|Hydrogenophilales 119069|Hydrogenophilales M Peptidoglycan polymerase that is essential for cell division ftsW - - ko:K03588 ko04112,map04112 - - - ko00000,ko00001,ko02000,ko03036 2.A.103.1 - - FTSW_RODA_SPOVE k59_113409_2 305700.B447_02923 2.73e-49 170.0 COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,2VHJ1@28216|Betaproteobacteria,2KU87@206389|Rhodocyclales 206389|Rhodocyclales M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) murD - 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase_C,Mur_ligase_M k59_801640_1 864051.BurJ1DRAFT_3799 1.84e-117 351.0 COG2937@1|root,COG2937@2|Bacteria,1MWZ6@1224|Proteobacteria,2W5VT@28216|Betaproteobacteria 28216|Betaproteobacteria I Belongs to the GPAT DAPAT family plsB - 2.3.1.15 ko:K00631 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_243990_1 391587.KAOT1_06182 2.4e-12 68.6 COG2227@1|root,COG2227@2|Bacteria 2|Bacteria H 3-demethylubiquinone-9 3-O-methyltransferase activity - - - ko:K20444 - - - - ko00000,ko01000,ko01005,ko02000 4.D.1.3 GT2,GT4 - Glyco_trans_1_4,Glycos_transf_2,Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31 k59_541851_1 84531.JMTZ01000006_gene3504 1.54e-89 277.0 COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,1RMF6@1236|Gammaproteobacteria,1X3KZ@135614|Xanthomonadales 135614|Xanthomonadales E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuC - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase k59_712424_1 1485544.JQKP01000012_gene2167 2.03e-07 48.9 COG0636@1|root,32S3K@2|Bacteria,1N1NA@1224|Proteobacteria,2VTY0@28216|Betaproteobacteria,44W3S@713636|Nitrosomonadales 28216|Betaproteobacteria C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpE - - ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_C k59_712424_2 1131553.JIBI01000011_gene744 7.61e-26 103.0 COG0711@1|root,COG0711@2|Bacteria,1RHZ0@1224|Proteobacteria,2VRMS@28216|Betaproteobacteria,372ZX@32003|Nitrosomonadales 28216|Betaproteobacteria C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpF - - ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_B k59_712424_3 1301098.PKB_5812 6.76e-11 62.8 COG0712@1|root,COG0712@2|Bacteria,1MVRH@1224|Proteobacteria,1S8X2@1236|Gammaproteobacteria 1236|Gammaproteobacteria C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpH GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - iSF_1195.SF3815,iSFxv_1172.SFxv_4157,iS_1188.S3953 OSCP k59_77522_1 472759.Nhal_3600 2.14e-14 78.6 COG1196@1|root,COG3264@1|root,COG1196@2|Bacteria,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,1WXKG@135613|Chromatiales 135613|Chromatiales DM mechanosensitive ion channel - - - ko:K05802 - - - - ko00000,ko02000 1.A.23.1.1 - - MS_channel,MscS_TM,MscS_porin k59_633454_1 1382306.JNIM01000001_gene121 1.57e-25 108.0 COG0317@1|root,COG0317@2|Bacteria,2G67Y@200795|Chloroflexi 200795|Chloroflexi KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance relA - 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_1134613_1 991905.SL003B_2212 1.17e-91 293.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2TQK9@28211|Alphaproteobacteria,4BP8W@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_968137_1 1380391.JIAS01000012_gene4273 4.72e-28 113.0 COG1270@1|root,COG1270@2|Bacteria,1MURM@1224|Proteobacteria,2TRZ8@28211|Alphaproteobacteria,2JQHP@204441|Rhodospirillales 204441|Rhodospirillales H Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group cobD - 6.3.1.10 ko:K02227 ko00860,ko01100,map00860,map01100 M00122 R06529,R07302 RC00090,RC00096 ko00000,ko00001,ko00002,ko01000 - - - CobD_Cbib k59_755075_1 266264.Rmet_3128 0.000845 43.5 COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,2VH32@28216|Betaproteobacteria,1JZPA@119060|Burkholderiaceae 28216|Betaproteobacteria M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) murG - 2.4.1.227 ko:K02563 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 - R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011 - GT28 - Glyco_tran_28_C,Glyco_transf_28 k59_755075_2 1323663.AROI01000006_gene3009 7.29e-34 129.0 COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,1RN88@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the MurCDEF family murC GO:0000166,GO:0000270,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008763,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034645,GO:0035639,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0046872,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - iECP_1309.ECP_0093 Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_155862_1 269799.Gmet_3460 1.65e-11 67.8 COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,42NC3@68525|delta/epsilon subdivisions,2WIJJ@28221|Deltaproteobacteria 28221|Deltaproteobacteria V PFAM ABC-2 type transporter - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 k59_414839_1 34506.g5815 1.86e-06 53.1 COG0488@1|root,KOG0927@2759|Eukaryota,3AHX4@33154|Opisthokonta,3BYSV@33208|Metazoa,3DFWV@33213|Bilateria 33208|Metazoa S ABC transporter - - - - - - - - - - - - ABC_tran,ABC_tran_Xtn k59_414839_2 1454004.AW11_02469 3.21e-60 200.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2VH16@28216|Betaproteobacteria,1KQAX@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria JKL Belongs to the DEAD box helicase family - - 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C k59_968164_1 1123393.KB891316_gene1682 2.82e-05 45.1 COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,2VH9I@28216|Betaproteobacteria,1KRD5@119069|Hydrogenophilales 28216|Betaproteobacteria P K+ potassium transporter kup - - ko:K03549 - - - - ko00000,ko02000 2.A.72 - - K_trans k59_968164_2 1122603.ATVI01000008_gene2150 7.96e-76 237.0 COG2008@1|root,COG2008@2|Bacteria,1MWCR@1224|Proteobacteria,1RNYX@1236|Gammaproteobacteria,1X5AE@135614|Xanthomonadales 135614|Xanthomonadales E Threonine aldolase - - 4.1.2.48 ko:K01620 ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230 - R00751,R06171 RC00312,RC00372 ko00000,ko00001,ko01000 - - - Beta_elim_lyase k59_499387_1 525368.HMPREF0591_4367 9.45e-38 148.0 COG3039@1|root,COG3039@2|Bacteria,2HW75@201174|Actinobacteria,237RJ@1762|Mycobacteriaceae 201174|Actinobacteria L PFAM transposase, IS4 family protein - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_1181471_1 1150469.RSPPHO_00296 2.25e-64 218.0 COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,2TQJT@28211|Alphaproteobacteria,2JQEQ@204441|Rhodospirillales 204441|Rhodospirillales C malic enzyme tme - 1.1.1.40 ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200 M00169,M00172 R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - - Malic_M,PTA_PTB,malic k59_499412_1 883078.HMPREF9695_00715 2.19e-76 239.0 COG0549@1|root,COG0549@2|Bacteria,1MWXC@1224|Proteobacteria,2TVMD@28211|Alphaproteobacteria,3JXQB@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Amino acid kinase family arcC - 2.7.2.2 ko:K00926 ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200 - R00150,R01395 RC00002,RC00043,RC02803,RC02804 ko00000,ko00001,ko01000 - - - AA_kinase k59_836212_2 994479.GL877879_gene5900 1.5e-10 57.8 COG0346@1|root,COG0346@2|Bacteria,2IKRF@201174|Actinobacteria,4E4DZ@85010|Pseudonocardiales 201174|Actinobacteria E PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - - - - - - - - - - Glyoxalase k59_1356142_1 977880.RALTA_A0749 1.27e-65 219.0 COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,2VI20@28216|Betaproteobacteria,1K2SU@119060|Burkholderiaceae 28216|Betaproteobacteria P transporter fbpB - - ko:K02011 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - BPD_transp_1 k59_968233_1 1469245.JFBG01000097_gene1355 7.01e-63 204.0 COG0673@1|root,COG0673@2|Bacteria 2|Bacteria S inositol 2-dehydrogenase activity - - - - - - - - - - - - GFO_IDH_MocA k59_1309438_1 861208.AGROH133_06202 3.55e-12 67.8 COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria,2TSDW@28211|Alphaproteobacteria,4BCQ8@82115|Rhizobiaceae 28211|Alphaproteobacteria S Phage Terminase - - - - - - - - - - - - Terminase_1 k59_113640_1 501479.ACNW01000057_gene4247 2.28e-25 108.0 COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,2TRKK@28211|Alphaproteobacteria 28211|Alphaproteobacteria M mechanosensitive ion channel MA20_40450 - - - - - - - - - - - MS_channel k59_155954_1 1333998.M2A_2188 6.14e-78 242.0 COG2834@1|root,COG2834@2|Bacteria,1MXW0@1224|Proteobacteria,2U3UR@28211|Alphaproteobacteria,4BR6M@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria M Outer membrane lipoprotein-sorting protein - - - - - - - - - - - - LolA_like k59_836247_1 626418.bglu_1g33210 5.41e-07 53.5 COG0617@1|root,COG0617@2|Bacteria,1MU2X@1224|Proteobacteria,2VIN5@28216|Betaproteobacteria,1K1SK@119060|Burkholderiaceae 28216|Betaproteobacteria J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'- nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases cca - 2.7.7.72 ko:K00974 ko03013,map03013 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016 - - - HD,PolyA_pol,PolyA_pol_RNAbd k59_836247_2 1206731.BAGB01000041_gene8963 0.000752 44.3 COG1309@1|root,COG1309@2|Bacteria,2IA5P@201174|Actinobacteria,4G0R1@85025|Nocardiaceae 201174|Actinobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_801861_1 748247.AZKH_0323 4.21e-117 351.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria 28216|Betaproteobacteria T response regulator - - - ko:K07714 ko02020,map02020 M00500 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_925915_1 1095769.CAHF01000022_gene339 2.51e-40 145.0 COG4966@1|root,COG4966@2|Bacteria,1RC4Q@1224|Proteobacteria,2VS7N@28216|Betaproteobacteria,476YR@75682|Oxalobacteraceae 28216|Betaproteobacteria NU Type IV Pilus-assembly protein W pilW - - ko:K02672 - - - - ko00000,ko02035,ko02044 - - - N_methyl,PilW k59_77710_1 1121939.L861_01745 1.12e-47 157.0 COG1765@1|root,COG1765@2|Bacteria,1QUE7@1224|Proteobacteria,1S84Z@1236|Gammaproteobacteria,1XKED@135619|Oceanospirillales 135619|Oceanospirillales O OsmC-like protein - - - - - - - - - - - - OsmC k59_77710_2 189753.AXAS01000055_gene5700 2.18e-26 105.0 COG2072@1|root,COG2072@2|Bacteria,1MWPJ@1224|Proteobacteria,2TSQA@28211|Alphaproteobacteria,3JT1R@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P Pyridine nucleotide-disulphide oxidoreductase - - - ko:K07222 - - - - ko00000 - - - Pyr_redox_3 k59_284054_1 1278309.KB907108_gene1549 7.21e-60 212.0 COG0771@1|root,COG2931@1|root,COG0771@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,1RNK8@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q COG2931 RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - DUF4347 k59_499515_1 378806.STAUR_8390 5.79e-52 188.0 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,42NYP@68525|delta/epsilon subdivisions,2WIPJ@28221|Deltaproteobacteria,2YWH3@29|Myxococcales 28221|Deltaproteobacteria S Insulinase (Peptidase family M16) - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_582411_1 1031711.RSPO_c01810 6.94e-19 82.0 COG2153@1|root,COG2153@2|Bacteria,1MZ86@1224|Proteobacteria,2VMR6@28216|Betaproteobacteria,1K8P2@119060|Burkholderiaceae 28216|Betaproteobacteria S PFAM GCN5-related N-acetyltransferase yjcF - - - - - - - - - - - 4HBT,Acetyltransf_10 k59_582411_2 118166.JH976537_gene2413 8.31e-60 203.0 COG1028@1|root,COG3347@1|root,COG1028@2|Bacteria,COG3347@2|Bacteria,1G0Q0@1117|Cyanobacteria,1H8S9@1150|Oscillatoriales 1117|Cyanobacteria IQ Class II Aldolase and Adducin N-terminal domain - - - - - - - - - - - - Aldolase_II,adh_short,adh_short_C2 k59_1060318_1 1380391.JIAS01000019_gene1128 1.61e-09 62.0 COG0154@1|root,COG0154@2|Bacteria,1MW3Z@1224|Proteobacteria,2TS56@28211|Alphaproteobacteria 28211|Alphaproteobacteria J COG0154 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit and related amidases - - - - - - - - - - - - Amidase k59_200993_1 316055.RPE_0635 3.12e-99 319.0 COG1038@1|root,COG1038@2|Bacteria,1NW9R@1224|Proteobacteria,2TXZK@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second - - 6.4.1.1 ko:K01958 ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230 M00173 R00344 RC00040,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,HMGL-like,PYC_OADA k59_77740_1 1304883.KI912532_gene1998 3.17e-48 170.0 COG3385@1|root,COG3385@2|Bacteria,1RA6A@1224|Proteobacteria,2VUMQ@28216|Betaproteobacteria 28216|Betaproteobacteria L PFAM Transposase, IS4-like - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_4 k59_244260_1 765911.Thivi_2848 8.57e-18 76.6 COG0254@1|root,COG0254@2|Bacteria,1MZ69@1224|Proteobacteria,1SCMH@1236|Gammaproteobacteria,1WZ1M@135613|Chromatiales 135613|Chromatiales J 50S ribosomal protein L31 rpmE - - ko:K02909 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L31 k59_201023_1 1177181.T9A_02930 2.88e-42 142.0 COG0256@1|root,COG0256@2|Bacteria,1RGY7@1224|Proteobacteria,1S5V2@1236|Gammaproteobacteria,1XK6F@135619|Oceanospirillales 135619|Oceanospirillales J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance rplR - - ko:K02881 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L18p k59_201023_2 999541.bgla_1g03180 1.76e-54 174.0 COG0097@1|root,COG0097@2|Bacteria,1R9YZ@1224|Proteobacteria,2VQ4W@28216|Betaproteobacteria,1JZVW@119060|Burkholderiaceae 28216|Betaproteobacteria J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center rplF - - ko:K02933 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L6 k59_32839_1 1502851.FG93_06106 3.93e-84 259.0 COG1903@1|root,COG1903@2|Bacteria,1MXU3@1224|Proteobacteria,2TRFH@28211|Alphaproteobacteria,3JX4U@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria H Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A cbiD - 2.1.1.195 ko:K02188 ko00860,ko01100,map00860,map01100 - R07773 RC00003,RC02051 ko00000,ko00001,ko01000 - - - CbiD k59_1356276_1 342113.DM82_2264 1.45e-38 142.0 COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,2VH09@28216|Betaproteobacteria,1JZXF@119060|Burkholderiaceae 28216|Betaproteobacteria H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis ubiD - 4.1.1.98 ko:K03182 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04985,R04986 RC00391 ko00000,ko00001,ko00002,ko01000 - - - UbiD k59_879466_1 857087.Metme_0540 1.58e-16 81.6 COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1MU9U@1224|Proteobacteria,1RNKA@1236|Gammaproteobacteria,1XDUX@135618|Methylococcales 135618|Methylococcales H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source nadE - 6.3.5.1 ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase,NAD_synthase k59_714128_1 1231391.AMZF01000025_gene1373 8.49e-120 351.0 COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,2VHC8@28216|Betaproteobacteria,3T1PM@506|Alcaligenaceae 28216|Betaproteobacteria C Catalyzes the reversible oxidation of malate to oxaloacetate mdh - 1.1.1.37 ko:K00024 ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740 R00342,R07136 RC00031 ko00000,ko00001,ko00002,ko01000 - - - Ldh_1_C,Ldh_1_N k59_543585_1 338969.Rfer_2572 2.42e-99 309.0 COG0322@1|root,COG2176@1|root,COG0322@2|Bacteria,COG2176@2|Bacteria,1QUVW@1224|Proteobacteria,2WGSG@28216|Betaproteobacteria 28216|Betaproteobacteria L DNA polymerase III, epsilon subunit - - 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - GIY-YIG,RNase_T k59_803406_1 1267005.KB911255_gene2653 8.66e-140 425.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2TRZD@28211|Alphaproteobacteria 28211|Alphaproteobacteria P TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3 k59_34346_1 1089552.KI911559_gene2978 3.22e-93 290.0 COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,2TS1Q@28211|Alphaproteobacteria,2JPWE@204441|Rhodospirillales 204441|Rhodospirillales D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ - - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin k59_927514_1 159450.NH14_22215 1.13e-93 294.0 COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,2VHI9@28216|Betaproteobacteria,1K36X@119060|Burkholderiaceae 28216|Betaproteobacteria L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,DnaG_DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2 k59_34373_1 203124.Tery_4975 1.24e-12 69.7 COG3415@1|root,COG3415@2|Bacteria,1G0GB@1117|Cyanobacteria,1H89N@1150|Oscillatoriales 1117|Cyanobacteria L Winged helix-turn helix - - - - - - - - - - - - DDE_3,HTH_23,HTH_32,HTH_33 k59_334004_1 257313.BP2575 2.44e-45 148.0 COG0292@1|root,COG0292@2|Bacteria,1RGU2@1224|Proteobacteria,2VRWF@28216|Betaproteobacteria,3T3XN@506|Alcaligenaceae 28216|Betaproteobacteria J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit rplT - - ko:K02887 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L20 k59_334004_2 76114.ebC8 2.64e-24 92.8 COG0291@1|root,COG0291@2|Bacteria,1N6V4@1224|Proteobacteria,2VVS9@28216|Betaproteobacteria,2KX60@206389|Rhodocyclales 206389|Rhodocyclales J Belongs to the bacterial ribosomal protein bL35 family rpmI - - ko:K02916 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L35p k59_334004_3 1288494.EBAPG3_4470 9.37e-71 218.0 COG0290@1|root,COG0290@2|Bacteria,1RDD2@1224|Proteobacteria,2VQ19@28216|Betaproteobacteria,372YM@32003|Nitrosomonadales 28216|Betaproteobacteria J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins infC - - ko:K02520 - - - - ko00000,ko03012,ko03029 - - - IF3_C,IF3_N k59_927599_1 1207063.P24_09931 5.21e-118 345.0 COG0714@1|root,COG0714@2|Bacteria,1MV5I@1224|Proteobacteria,2TREB@28211|Alphaproteobacteria,2JQDG@204441|Rhodospirillales 204441|Rhodospirillales S AAA domain (dynein-related subfamily) - - - - - - - - - - - - AAA,AAA_5 k59_501172_1 3712.Bo8g004180.1 3.86e-34 128.0 COG0667@1|root,KOG1575@2759|Eukaryota,37KG8@33090|Viridiplantae,3G8DZ@35493|Streptophyta,3HPFB@3699|Brassicales 35493|Streptophyta C voltage-gated potassium channel subunit beta - GO:0005575,GO:0005623,GO:0005886,GO:0005911,GO:0009506,GO:0016020,GO:0030054,GO:0044464,GO:0055044,GO:0071944 - - - - - - - - - - Aldo_ket_red k59_1104482_1 1255043.TVNIR_1120 2.02e-20 90.9 COG1140@1|root,COG1140@2|Bacteria,1MW9Q@1224|Proteobacteria,1RNMJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria C nitrate reductase beta subunit - - 1.7.5.1 ko:K00371,ko:K17051 ko00910,ko01120,ko02020,map00910,map01120,map02020 M00529,M00530,M00804 R00798,R01106,R09497 RC02812 ko00000,ko00001,ko00002,ko01000,ko02000 5.A.3.1,5.A.3.8 - - Fer4_11 k59_1104543_1 411684.HPDFL43_19547 1.06e-79 254.0 COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2TQP0@28211|Alphaproteobacteria,43IGY@69277|Phyllobacteriaceae 28211|Alphaproteobacteria P Belongs to the ABC transporter superfamily yejF GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006857,GO:0008144,GO:0008150,GO:0015399,GO:0015405,GO:0015833,GO:0015893,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0035672,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0042626,GO:0042884,GO:0042886,GO:0042891,GO:0043167,GO:0043168,GO:0043492,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K02031,ko:K02032,ko:K13896 ko02010,ko02024,map02010,map02024 M00239,M00349 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.21,3.A.1.5.24 - - ABC_tran,oligo_HPY k59_1268642_1 59538.XP_005976936.1 3.59e-75 244.0 COG0147@1|root,KOG1223@2759|Eukaryota,38FJ5@33154|Opisthokonta 33154|Opisthokonta E anthranilate synthase activity TRP2 GO:0000162,GO:0003674,GO:0003824,GO:0004049,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016833,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind k59_1012412_2 644966.Tmar_0214 1.1e-22 105.0 COG0421@1|root,COG0421@2|Bacteria,1UI4A@1239|Firmicutes,25GIE@186801|Clostridia 186801|Clostridia E Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - - - - - - - - - - Spermine_synth k59_672516_1 443152.MDG893_06900 1.52e-51 177.0 COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,1RNY5@1236|Gammaproteobacteria,464BX@72275|Alteromonadaceae 1236|Gammaproteobacteria C Electron transfer flavoprotein-ubiquinone oxidoreductase etfD - 1.5.5.1 ko:K00311 - - - - ko00000,ko01000 - - - ETF_QO,FAD_binding_2,NAD_binding_8,Thi4 k59_927814_2 1547437.LL06_00335 1.12e-57 189.0 COG0715@1|root,COG0715@2|Bacteria,1PKQN@1224|Proteobacteria,2TSRB@28211|Alphaproteobacteria,43IZ4@69277|Phyllobacteriaceae 28211|Alphaproteobacteria P 4,5-dihydroxyphthalate decarboxylase - - 4.1.1.55 ko:K04102 ko00624,ko01100,ko01120,map00624,map01100,map01120 M00623 R01635,R05375 RC00390 ko00000,ko00001,ko00002,ko01000 - - - NMT1 k59_34692_1 1366050.N234_24970 3.33e-13 70.1 COG4133@1|root,COG4133@2|Bacteria,1MZPC@1224|Proteobacteria,2VMGA@28216|Betaproteobacteria,1K840@119060|Burkholderiaceae 28216|Betaproteobacteria O once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system ccmA - 3.6.3.41 ko:K02193 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.107 - - ABC_tran k59_34692_2 713587.THITH_06910 1.46e-63 202.0 COG2386@1|root,COG2386@2|Bacteria,1NJB0@1224|Proteobacteria,1RRFJ@1236|Gammaproteobacteria,1WWPG@135613|Chromatiales 135613|Chromatiales U Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes - - - ko:K02194 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko02000 3.A.1.107 - - CcmB k59_202840_1 1144319.PMI16_04329 5.18e-14 70.9 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,4733N@75682|Oxalobacteraceae 28216|Betaproteobacteria T Sigma-54 interaction domain ntrC GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0043565,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141 - ko:K07712 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_202840_2 1454004.AW11_03362 1.06e-41 150.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,1KQCV@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria T Two component, sigma54 specific, transcriptional regulator, Fis family ntrC GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0043565,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141 - ko:K07712 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_757062_2 748247.AZKH_4212 1.1e-87 272.0 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,2VIHR@28216|Betaproteobacteria,2KUS9@206389|Rhodocyclales 206389|Rhodocyclales C glutamate synthase gltD - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - Fer4_20,Pyr_redox_2 k59_837917_1 331869.BAL199_10597 1.1e-105 314.0 COG0601@1|root,COG0601@2|Bacteria,1MWXF@1224|Proteobacteria,2TR7C@28211|Alphaproteobacteria,4BPHM@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria P Binding-protein-dependent transport system inner membrane component - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_79612_1 76114.ebA4237 2.71e-139 402.0 COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,2VHZU@28216|Betaproteobacteria,2KVHR@206389|Rhodocyclales 206389|Rhodocyclales H Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group ctaB - 2.5.1.141 ko:K02257 ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714 M00154 R07411 RC01786 ko00000,ko00001,ko00002,ko01000,ko01006,ko03029 - - - UbiA k59_79612_2 1123367.C666_13270 9.4e-09 54.7 COG1999@1|root,COG1999@2|Bacteria,1RHJ8@1224|Proteobacteria,2VR3M@28216|Betaproteobacteria,2KWGG@206389|Rhodocyclales 206389|Rhodocyclales S protein SCO1 SenC PrrC, involved in biogenesis of respiratory and photosynthetic systems - - - ko:K07152 - - - - ko00000,ko03029 - - - SCO1-SenC k59_544016_1 269796.Rru_A1544 5.97e-46 168.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,2JQ4H@204441|Rhodospirillales 204441|Rhodospirillales T signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - - - - - - - - - - EAL,GGDEF,PAS_9 k59_202887_1 398525.KB900701_gene1353 3.66e-64 204.0 COG0596@1|root,COG0596@2|Bacteria,1Q4C8@1224|Proteobacteria,2TTW5@28211|Alphaproteobacteria,3JTEC@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Serine aminopeptidase, S33 MA20_23630 - - - - - - - - - - - Abhydrolase_1 k59_1358155_1 765911.Thivi_4543 3.93e-40 152.0 COG0515@1|root,COG1262@1|root,COG2909@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria,COG2909@2|Bacteria,1NQ5K@1224|Proteobacteria,1T4K6@1236|Gammaproteobacteria,1X2K2@135613|Chromatiales 135613|Chromatiales KLT Protein tyrosine kinase - - 2.7.11.1 ko:K11912 ko02025,ko03070,map02025,map03070 - - - ko00000,ko00001,ko01000,ko01001,ko02044 - - - FGE-sulfatase,Pkinase k59_1358155_2 1408311.JNJM01000035_gene178 1.23e-08 58.5 COG0745@1|root,COG0745@2|Bacteria,1V042@1239|Firmicutes,24IM1@186801|Clostridia,2PRP7@265975|Oribacterium 186801|Clostridia KT cheY-homologous receiver domain - - - - - - - - - - - - Hemerythrin,Response_reg k59_157930_1 261292.Nit79A3_3561 1.38e-83 257.0 COG0414@1|root,COG0414@2|Bacteria,1MV1S@1224|Proteobacteria,2VHF1@28216|Betaproteobacteria,372PX@32003|Nitrosomonadales 28216|Betaproteobacteria H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate panC - 6.3.2.1 ko:K01918 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R02473 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_ligase k59_714581_1 1268622.AVS7_02450 1.65e-30 122.0 COG0683@1|root,COG0683@2|Bacteria,1MWR8@1224|Proteobacteria,2VHH6@28216|Betaproteobacteria,4AD33@80864|Comamonadaceae 28216|Betaproteobacteria E Extracellular liganD-binding receptor - - - - - - - - - - - - Peripla_BP_6 k59_837954_1 247634.GPB2148_3470 2.72e-25 108.0 COG2188@1|root,COG2188@2|Bacteria,1QVF7@1224|Proteobacteria,1S5D3@1236|Gammaproteobacteria,1J8FY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Putative porin - GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 - - - - - - - - - - Porin_5 k59_1268884_1 1122604.JONR01000011_gene3716 1.01e-12 71.6 COG0642@1|root,COG2205@2|Bacteria,1MUZQ@1224|Proteobacteria,1RMZT@1236|Gammaproteobacteria,1X3FI@135614|Xanthomonadales 135614|Xanthomonadales T Histidine kinase kdpD - 2.7.13.3 ko:K07646 ko02020,map02020 M00454 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - DUF4118,GAF_3,HATPase_c,HisKA,KdpD,Usp k59_1183580_1 498211.CJA_3775 5.68e-34 133.0 COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,1RMFJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB btuB - - ko:K16092 - - - - ko00000,ko02000 1.B.14.3 - - Plug,TonB_dep_Rec k59_837986_1 1131269.AQVV01000005_gene401 1.76e-48 167.0 COG0379@1|root,COG0379@2|Bacteria 2|Bacteria H quinolinate synthetase A activity nadA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0030312,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.5.1.72 ko:K03517 ko00760,ko01100,map00760,map01100 M00115 R04292 RC01119 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b0750,iAPECO1_1312.APECO1_1338,iB21_1397.B21_00692,iBWG_1329.BWG_0602,iECBD_1354.ECBD_2917,iECB_1328.ECB_00703,iECDH10B_1368.ECDH10B_0817,iECDH1ME8569_1439.ECDH1ME8569_0703,iECD_1391.ECD_00703,iECED1_1282.ECED1_0711,iECOK1_1307.ECOK1_0750,iECP_1309.ECP_0761,iECS88_1305.ECS88_0766,iECSP_1301.ECSP_0802,iECs_1301.ECs0778,iETEC_1333.ETEC_0754,iEcDH1_1363.EcDH1_2892,iEcolC_1368.EcolC_2912,iHN637.CLJU_RS12020,iJN746.PP_1231,iJO1366.b0750,iJR904.b0750,iUMN146_1321.UM146_13905,iUTI89_1310.UTI89_C0747,iY75_1357.Y75_RS03905,iZ_1308.Z0919 NadA k59_1104891_1 1279019.ARQK01000058_gene671 8.24e-116 341.0 COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,1RNB6@1236|Gammaproteobacteria,1WWMZ@135613|Chromatiales 135613|Chromatiales E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate asd - 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_1136489_1 240015.ACP_1739 4.79e-15 75.1 COG0809@1|root,COG0809@2|Bacteria,3Y336@57723|Acidobacteria,2JI3K@204432|Acidobacteriia 204432|Acidobacteriia J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) queA - 2.4.99.17 ko:K07568 - - - - ko00000,ko01000,ko03016 - - - Queuosine_synth k59_1136489_2 861299.J421_2575 3.37e-45 156.0 COG2255@1|root,COG2255@2|Bacteria,1ZT9W@142182|Gemmatimonadetes 142182|Gemmatimonadetes L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing ruvB - 3.6.4.12 ko:K03551 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvB_C,RuvB_N k59_1104904_1 1304883.KI912532_gene1966 1.49e-65 213.0 COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,2VIGA@28216|Betaproteobacteria,2KUKY@206389|Rhodocyclales 206389|Rhodocyclales J histidyl-tRNA synthetase hisS - 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_His k59_34858_1 523791.Kkor_1134 3.02e-99 304.0 COG1012@1|root,COG1012@2|Bacteria,1MW72@1224|Proteobacteria,1RY9G@1236|Gammaproteobacteria,1XI44@135619|Oceanospirillales 135619|Oceanospirillales C belongs to the aldehyde dehydrogenase family - - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_928005_1 402881.Plav_0618 2.11e-28 112.0 COG3173@1|root,COG3173@2|Bacteria,1MWAK@1224|Proteobacteria,2TT2N@28211|Alphaproteobacteria,1JN17@119043|Rhodobiaceae 28211|Alphaproteobacteria S PFAM aminoglycoside phosphotransferase MA20_31030 - - - - - - - - - - - APH k59_928005_2 1304877.KI519400_gene638 4.94e-38 137.0 COG2030@1|root,COG2030@2|Bacteria,1MUR2@1224|Proteobacteria,2TUM7@28211|Alphaproteobacteria,3JR27@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I N-terminal half of MaoC dehydratase - - - - - - - - - - - - MaoC_dehydrat_N,MaoC_dehydratas k59_928006_1 1411123.JQNH01000001_gene502 6.07e-88 269.0 COG2358@1|root,COG2358@2|Bacteria,1R3ZR@1224|Proteobacteria,2TSND@28211|Alphaproteobacteria 28211|Alphaproteobacteria S transport system periplasmic component MA20_27285 - - - - - - - - - - - NMT1_3 k59_79752_1 1336208.JADY01000001_gene1132 9.59e-67 214.0 COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,2TRMT@28211|Alphaproteobacteria,2JQ0D@204441|Rhodospirillales 204441|Rhodospirillales E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde argC - 1.2.1.38 ko:K00145 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R03443 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_881175_1 648757.Rvan_0473 8.32e-63 202.0 COG2267@1|root,COG2267@2|Bacteria,1NTH9@1224|Proteobacteria,2TWFW@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_881175_2 196367.JNFG01000013_gene5122 7.35e-38 139.0 COG0436@1|root,COG0436@2|Bacteria,1MX6F@1224|Proteobacteria,2VJI9@28216|Betaproteobacteria,1K4H6@119060|Burkholderiaceae 28216|Betaproteobacteria E aminotransferase class I and II - - - - - - - - - - - - Aminotran_1_2 k59_672750_1 314278.NB231_13186 2.78e-22 90.5 COG3027@1|root,COG3027@2|Bacteria,1N6YN@1224|Proteobacteria,1SCBI@1236|Gammaproteobacteria,1WZ69@135613|Chromatiales 135613|Chromatiales D Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division - - - ko:K09888 - - - - ko00000,ko03036 - - - ZapA k59_1062754_1 118166.JH976537_gene152 3.76e-26 100.0 COG0229@1|root,COG0229@2|Bacteria,1G5S6@1117|Cyanobacteria,1HB1V@1150|Oscillatoriales 1117|Cyanobacteria O Belongs to the MsrB Met sulfoxide reductase family msrB - 1.8.4.12 ko:K07305 - - - - ko00000,ko01000 - - - SelR k59_584517_1 500635.MITSMUL_04857 1.5e-12 72.8 COG1215@1|root,COG1215@2|Bacteria,1TR2P@1239|Firmicutes,4H226@909932|Negativicutes 909932|Negativicutes M PFAM Glycosyl transferase family 2 - - 2.4.1.212 ko:K00752 - - - - ko00000,ko01000,ko01003,ko02000 4.D.1.1.10,4.D.1.1.4,4.D.1.1.5 GT2 - Glycos_transf_2,PilZ k59_636130_1 398527.Bphyt_4283 1.14e-99 309.0 COG0129@1|root,COG0129@2|Bacteria,1MV4I@1224|Proteobacteria,2VKKY@28216|Betaproteobacteria,1K2X5@119060|Burkholderiaceae 28216|Betaproteobacteria EG Belongs to the IlvD Edd family - - 4.2.1.25,4.2.1.82,4.2.1.9 ko:K01687,ko:K13875,ko:K22186 ko00040,ko00053,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00040,map00053,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R02429,R02522,R04441,R05070 RC00468,RC00543,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_636173_1 713586.KB900536_gene647 1.53e-66 217.0 COG0114@1|root,COG0114@2|Bacteria,1MUQI@1224|Proteobacteria,1RNUS@1236|Gammaproteobacteria,1WWB4@135613|Chromatiales 135613|Chromatiales C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate fumC - 4.2.1.2 ko:K01679 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211 M00009,M00011,M00173,M00376 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - FumaraseC_C,Lyase_1 k59_1012782_1 404589.Anae109_0941 5.33e-43 156.0 COG0668@1|root,COG0668@2|Bacteria,1MXD2@1224|Proteobacteria,42M92@68525|delta/epsilon subdivisions,2WJ7J@28221|Deltaproteobacteria,2YVBA@29|Myxococcales 28221|Deltaproteobacteria M PFAM MscS Mechanosensitive ion channel - - - ko:K16052 - - - - ko00000,ko02000 1.A.23.4 - - MS_channel k59_970432_1 348824.LPU83_2098 1.13e-156 444.0 COG3293@1|root,COG3293@2|Bacteria,1PVIT@1224|Proteobacteria,2TURP@28211|Alphaproteobacteria,4BDDJ@82115|Rhizobiaceae 28211|Alphaproteobacteria L Transposase DDE domain - - - ko:K07492 - - - - ko00000 - - - DDE_Tnp_1,DDE_Tnp_1_2,DUF4096 k59_158161_1 1382306.JNIM01000001_gene1523 1.35e-26 107.0 COG1136@1|root,COG1136@2|Bacteria,2G5S3@200795|Chloroflexi 200795|Chloroflexi V PFAM ABC transporter related - - - ko:K02031,ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran k59_636248_1 266779.Meso_0340 1.28e-101 328.0 COG0642@1|root,COG0784@1|root,COG4192@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,COG4192@2|Bacteria,1MUY7@1224|Proteobacteria,2TR1M@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,PAS_7,Response_reg,dCache_1 k59_158230_1 614083.AWQR01000005_gene924 8.03e-129 379.0 COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,2VIWB@28216|Betaproteobacteria,4AAKI@80864|Comamonadaceae 28216|Betaproteobacteria C Belongs to the heme-copper respiratory oxidase family ccoN - 1.9.3.1 ko:K00404 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - COX1 k59_928199_1 686340.Metal_2275 4.71e-94 286.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,1XEUM@135618|Methylococcales 135618|Methylococcales P PFAM Ammonium Transporter - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_757422_1 795666.MW7_3132 1.3e-40 141.0 COG0634@1|root,COG0634@2|Bacteria,1NRT8@1224|Proteobacteria,2VRM9@28216|Betaproteobacteria,1KFT4@119060|Burkholderiaceae 28216|Betaproteobacteria F Phosphoribosyl transferase domain hpt - 2.4.2.8 ko:K00760 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 - R00190,R01132,R01229,R02142,R08237,R08238,R08245 RC00063,RC00122 ko00000,ko00001,ko01000 - - - Pribosyltran k59_757422_2 1005048.CFU_1296 4.79e-09 56.6 COG1210@1|root,COG1210@2|Bacteria,1MV5F@1224|Proteobacteria,2VH00@28216|Betaproteobacteria,472BN@75682|Oxalobacteraceae 28216|Betaproteobacteria M UTP-glucose-1-phosphate uridylyltransferase galU - 2.7.7.9 ko:K00963 ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130 M00129,M00361,M00362,M00549 R00289 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_928245_2 1042377.AFPJ01000008_gene2022 2.11e-32 126.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,1RNB5@1236|Gammaproteobacteria,469JA@72275|Alteromonadaceae 1236|Gammaproteobacteria C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_506215_1 1288494.EBAPG3_11670 7.66e-101 304.0 COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,2VH8Q@28216|Betaproteobacteria,37261@32003|Nitrosomonadales 28216|Betaproteobacteria M Peptidoglycan polymerase that is essential for cell wall elongation mrdB - - ko:K05837 - - - - ko00000,ko03036 - - - FTSW_RODA_SPOVE k59_841973_1 552811.Dehly_1275 3.05e-53 183.0 COG1783@1|root,COG1783@2|Bacteria 2|Bacteria S DNA packaging - - - - - - - - - - - - Terminase_6,Terminase_6C k59_339091_1 1502851.FG93_01574 5.04e-27 109.0 COG0697@1|root,COG0697@2|Bacteria,1NEYM@1224|Proteobacteria,2TX6U@28211|Alphaproteobacteria,3JRXZ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria EG EamA-like transporter family MA20_29065 - - - - - - - - - - - EamA k59_1273641_1 479433.Caci_6679 2.76e-25 102.0 COG1309@1|root,COG1309@2|Bacteria,2GP92@201174|Actinobacteria 201174|Actinobacteria K transcriptional regulator - - - - - - - - - - - - TetR_N k59_1273641_2 32057.KB217478_gene5147 1.49e-22 100.0 COG2114@1|root,COG2203@1|root,COG2114@2|Bacteria,COG2203@2|Bacteria,1FZXP@1117|Cyanobacteria,1HMXI@1161|Nostocales 1117|Cyanobacteria T PFAM Adenylate and Guanylate cyclase catalytic domain - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - GAF_2,Guanylate_cyc,PAS,PAS_8,PAS_9 k59_761806_1 1449350.OCH239_22065 2.15e-13 67.4 COG1268@1|root,COG1268@2|Bacteria,1RH78@1224|Proteobacteria,2U9DN@28211|Alphaproteobacteria,4KNM9@93682|Roseivivax 28211|Alphaproteobacteria S BioY family bioY - - ko:K03523 ko02010,map02010 M00581,M00582 - - ko00000,ko00001,ko00002,ko02000 2.A.88.1,2.A.88.2 - - BioY k59_761806_2 272568.GDI0297 2.97e-24 97.1 COG3415@1|root,COG3415@2|Bacteria,1RJ69@1224|Proteobacteria,2UB2N@28211|Alphaproteobacteria,2JY4D@204441|Rhodospirillales 204441|Rhodospirillales L Homeodomain-like domain - - - - - - - - - - - - HTH_23,HTH_32,HTH_33 k59_761806_3 452662.SJA_C1-35040 1.85e-97 286.0 COG3335@1|root,COG3335@2|Bacteria,1P76X@1224|Proteobacteria,2U16U@28211|Alphaproteobacteria,2K5DS@204457|Sphingomonadales 204457|Sphingomonadales L Transposase or inactivated derivative - - - ko:K07494 - - - - ko00000 - - - DDE_3 k59_761806_4 381666.H16_B0890 1.05e-08 55.5 COG0600@1|root,COG0600@2|Bacteria,1MWDJ@1224|Proteobacteria,2VJM9@28216|Betaproteobacteria,1K0NT@119060|Burkholderiaceae 28216|Betaproteobacteria P binding-protein-dependent transport systems inner membrane component tauC - - ko:K02050,ko:K15552 ko00920,ko02010,map00920,map02010 M00188,M00435 - - ko00000,ko00001,ko00002,ko02000 3.A.1.16,3.A.1.17,3.A.1.17.1,3.A.1.17.4 - - BPD_transp_1 k59_339142_1 1049564.TevJSym_ac00600 1.85e-137 407.0 COG1271@1|root,COG1271@2|Bacteria 2|Bacteria C aerobic electron transport chain - - 1.10.3.14 ko:K00425,ko:K08738 ko00190,ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00190,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00153,M00595 R10151,R11325 RC00061,RC03151,RC03152 ko00000,ko00001,ko00002,ko01000 3.D.4.3,3.D.4.6 - - Cyt_bd_oxida_I,Cytochrome_CBB3 k59_1231195_1 1095769.CAHF01000022_gene339 8.71e-28 111.0 COG4966@1|root,COG4966@2|Bacteria,1RC4Q@1224|Proteobacteria,2VS7N@28216|Betaproteobacteria,476YR@75682|Oxalobacteraceae 28216|Betaproteobacteria NU Type IV Pilus-assembly protein W pilW - - ko:K02672 - - - - ko00000,ko02035,ko02044 - - - N_methyl,PilW k59_548858_1 395494.Galf_0151 2.43e-39 139.0 COG0351@1|root,COG0351@2|Bacteria,1MU9J@1224|Proteobacteria,2VKD2@28216|Betaproteobacteria,44V55@713636|Nitrosomonadales 28216|Betaproteobacteria H Phosphomethylpyrimidine kinase thiD - 2.7.1.49,2.7.4.7 ko:K00941 ko00730,ko01100,map00730,map01100 M00127 R03471,R04509 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Phos_pyr_kin k59_548858_2 1348657.M622_11205 3.8e-09 57.4 COG0352@1|root,COG0352@2|Bacteria,1RDSU@1224|Proteobacteria,2VSR5@28216|Betaproteobacteria,2KW2I@206389|Rhodocyclales 206389|Rhodocyclales H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) thiE - 2.5.1.3 ko:K00788 ko00730,ko01100,map00730,map01100 M00127 R03223,R10712 RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 - - - TMP-TENI k59_162782_1 1198452.Jab_2c06250 1.06e-72 238.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2VH0Y@28216|Betaproteobacteria,472N4@75682|Oxalobacteraceae 28216|Betaproteobacteria I 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain fadB - 1.1.1.35 ko:K07516 ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212 M00087 R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_1052039_1 247633.GP2143_09832 6.67e-109 323.0 COG2273@1|root,COG2273@2|Bacteria,1NFHX@1224|Proteobacteria,1RRPK@1236|Gammaproteobacteria 1236|Gammaproteobacteria G COG2273 Beta-glucanase Beta-glucan synthetase - - - - - - - - - - - - Glyco_hydro_16 k59_407210_1 84531.JMTZ01000024_gene4056 1.55e-17 80.9 COG2732@1|root,COG2732@2|Bacteria,1RD25@1224|Proteobacteria,1STYV@1236|Gammaproteobacteria,1X7KW@135614|Xanthomonadales 135614|Xanthomonadales K (barnase) inhibitor - - - - - - - - - - - - Barstar k59_407210_2 1286631.X805_16800 3.06e-45 151.0 COG0494@1|root,COG0494@2|Bacteria,1RH6N@1224|Proteobacteria,2VR3U@28216|Betaproteobacteria,1KKSR@119065|unclassified Burkholderiales 28216|Betaproteobacteria L Nudix hydrolase ntpA - 3.6.1.67 ko:K08310 ko00790,map00790 M00126 R04638 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NUDIX k59_1217287_1 953739.SVEN_4281 2e-16 77.8 COG3485@1|root,COG3485@2|Bacteria,2GNNC@201174|Actinobacteria 201174|Actinobacteria Q catechol 1,2-dioxygenase - - - - - - - - - - - - Dioxygenase_C k59_1217287_2 570967.JMLV01000006_gene178 1.65e-52 166.0 COG1146@1|root,COG1146@2|Bacteria,1RH5I@1224|Proteobacteria,2U98K@28211|Alphaproteobacteria,2JSMY@204441|Rhodospirillales 204441|Rhodospirillales C Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions fdxA - - ko:K05524 - - - - ko00000 - - - DUF3470,Fer4,Fer4_4 k59_705730_1 155515.JP36_02760 9.78e-40 139.0 COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,1RNWR@1236|Gammaproteobacteria,1Y74P@135625|Pasteurellales 135625|Pasteurellales C Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family frdB - 1.3.5.4 ko:K00245 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00150,M00173 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - Fer2_3,Fer4_8 k59_705730_2 457425.XNR_3934 2.84e-15 76.6 COG1053@1|root,COG1053@2|Bacteria,2GJ45@201174|Actinobacteria 201174|Actinobacteria C succinate dehydrogenase sdhA GO:0000104,GO:0000166,GO:0001539,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0006113,GO:0006928,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016491,GO:0016627,GO:0022607,GO:0022900,GO:0030030,GO:0030031,GO:0032991,GO:0033554,GO:0036094,GO:0040011,GO:0043167,GO:0043168,GO:0044085,GO:0044237,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0044780,GO:0044781,GO:0045273,GO:0045274,GO:0045283,GO:0045284,GO:0045333,GO:0048037,GO:0048870,GO:0050660,GO:0050662,GO:0050896,GO:0051179,GO:0051674,GO:0051716,GO:0055114,GO:0070469,GO:0070470,GO:0070925,GO:0071840,GO:0071944,GO:0071949,GO:0071973,GO:0097159,GO:0097588,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363 1.3.5.1,1.3.5.4,1.4.3.16 ko:K00239,ko:K00278 ko00020,ko00190,ko00250,ko00650,ko00720,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00250,map00650,map00720,map00760,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00115,M00149,M00173,M00374,M00376 R00357,R00481,R02164 RC00006,RC00045,RC02566 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_535201_1 640081.Dsui_1042 3.41e-72 225.0 COG3568@1|root,COG3568@2|Bacteria,1MVN7@1224|Proteobacteria,2VJYW@28216|Betaproteobacteria,2KV21@206389|Rhodocyclales 206389|Rhodocyclales L Endonuclease Exonuclease phosphatase - - - - - - - - - - - - Exo_endo_phos k59_961348_1 1131451.O1K_06532 1.65e-54 190.0 COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,1RN4K@1236|Gammaproteobacteria,1X3IX@135614|Xanthomonadales 135614|Xanthomonadales C Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_277131_1 1144342.PMI40_04735 1.19e-62 199.0 COG1234@1|root,COG1234@2|Bacteria,1QU4B@1224|Proteobacteria,2VH0D@28216|Betaproteobacteria 28216|Betaproteobacteria S beta-lactamase domain protein - - 3.1.4.17 ko:K01120 ko00230,map00230 - R00191,R01234 RC00296 ko00000,ko00001,ko01000 - - - Lactamase_B_2 k59_277131_2 1000565.METUNv1_02454 1.12e-113 350.0 COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,2VJ72@28216|Betaproteobacteria,2KVW3@206389|Rhodocyclales 206389|Rhodocyclales T CHASE2 - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CHASE2,Guanylate_cyc k59_1217353_1 1219375.CM002139_gene2424 2.63e-78 248.0 COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,1RMV1@1236|Gammaproteobacteria,1X4AB@135614|Xanthomonadales 135614|Xanthomonadales E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family argD - - - - - - - - - - - Aminotran_3 k59_70824_2 1207076.ALAT01000002_gene1301 3.32e-108 322.0 COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,1RMSS@1236|Gammaproteobacteria,1Z160@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_int_SAM_4,Phage_integrase k59_1094485_1 118161.KB235918_gene48 7.61e-26 103.0 COG3316@1|root,COG3316@2|Bacteria,1G3EB@1117|Cyanobacteria 1117|Cyanobacteria L COG3316 Transposase and inactivated derivatives - - - - - - - - - - - - DDE_Tnp_IS240 k59_1094485_2 1206725.BAFU01000199_gene1899 2.25e-28 109.0 COG3328@1|root,COG3328@2|Bacteria,2GM8F@201174|Actinobacteria,4FX9W@85025|Nocardiaceae 201174|Actinobacteria L Transposase, Mutator family - - - - - - - - - - - - Transposase_mut k59_194123_1 983917.RGE_45310 2.28e-48 177.0 COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,2VIJ7@28216|Betaproteobacteria,1KJYE@119065|unclassified Burkholderiales 28216|Betaproteobacteria M Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane lptD - - ko:K04744 - - - - ko00000,ko02000 1.B.42.1 - - OstA,OstA_C k59_277163_2 1101195.Meth11DRAFT_2282 1.07e-66 212.0 COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,2VHI8@28216|Betaproteobacteria,2KKCT@206350|Nitrosomonadales 206350|Nitrosomonadales M Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis lpxC - 3.5.1.108 ko:K02535 ko00540,ko01100,map00540,map01100 M00060 R04587 RC00166,RC00300 ko00000,ko00001,ko00002,ko01000,ko01005 - - - LpxC k59_705806_1 189753.AXAS01000075_gene6010 9.93e-63 208.0 COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2TRXG@28211|Alphaproteobacteria,3JVHX@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L Transposase - - - ko:K07487 - - - - ko00000 - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_535282_1 1008459.TASI_0180 5.01e-17 82.0 COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,2VHBZ@28216|Betaproteobacteria,3T1WY@506|Alcaligenaceae 28216|Betaproteobacteria M Catalyzes cross-linking of the peptidoglycan cell wall mrdA - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase k59_535282_2 1562701.BBOF01000061_gene1726 1.82e-14 71.2 COG2891@1|root,COG2891@2|Bacteria,1RBNF@1224|Proteobacteria,2VQQ3@28216|Betaproteobacteria,1K3V9@119060|Burkholderiaceae 28216|Betaproteobacteria M Rod shape-determining protein MreD mreD - - ko:K03571 - - - - ko00000,ko03036 9.B.157.1 - - MreD k59_961429_1 395019.Bmul_2878 1.74e-44 160.0 COG0477@1|root,COG2814@2|Bacteria,1MVHG@1224|Proteobacteria,2VPR2@28216|Betaproteobacteria,1KH5M@119060|Burkholderiaceae 28216|Betaproteobacteria EGP Uncharacterised MFS-type transporter YbfB - - - - - - - - - - - - MFS_1 k59_1301918_1 887062.HGR_16815 8.81e-11 63.2 COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,2VIS2@28216|Betaproteobacteria,4AC2V@80864|Comamonadaceae 28216|Betaproteobacteria J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus fmt - 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - - Formyl_trans_C,Formyl_trans_N k59_1301918_2 1122236.KB905143_gene97 8.82e-25 106.0 COG0144@1|root,COG0144@2|Bacteria,1MWPE@1224|Proteobacteria,2VI4V@28216|Betaproteobacteria,2KKZV@206350|Nitrosomonadales 206350|Nitrosomonadales J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA - - 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F,NusB k59_1094555_1 981369.JQMJ01000004_gene4143 0.000133 48.5 COG0683@1|root,COG0683@2|Bacteria,2GMIT@201174|Actinobacteria,2NHVQ@228398|Streptacidiphilus 201174|Actinobacteria E Receptor family ligand binding region - - - - - - - - - - - - Peripla_BP_6 k59_795131_1 400682.PAC_15705831 1.89e-37 144.0 COG4631@1|root,KOG0430@2759|Eukaryota 2759|Eukaryota C xanthine catabolic process - - 1.17.1.4,1.17.3.2,1.2.3.1 ko:K00106,ko:K00157 ko00230,ko00232,ko00280,ko00350,ko00380,ko00750,ko00760,ko00830,ko00982,ko00983,ko01100,ko01110,ko01120,ko04146,ko04630,map00230,map00232,map00280,map00350,map00380,map00750,map00760,map00830,map00982,map00983,map01100,map01110,map01120,map04146,map04630 M00546 R01709,R01768,R01769,R02103,R02107,R02125,R02657,R03871,R04085,R04904,R07942,R07977,R07978,R07979,R08235,R08349,R08384,R08408 RC00075,RC00080,RC00143,RC00218,RC00242,RC01073,RC01074,RC02017,RC02199 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2,CO_deh_flav_C,FAD_binding_5,Fer2,Fer2_2 k59_625653_1 187272.Mlg_2774 3.84e-29 118.0 COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,1RPRC@1236|Gammaproteobacteria,1WVYV@135613|Chromatiales 135613|Chromatiales J Arginyl-tRNA synthetase argS - 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_1301940_1 497321.C664_00840 1.14e-92 294.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2VHSK@28216|Betaproteobacteria,2KV96@206389|Rhodocyclales 206389|Rhodocyclales KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance relA - 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_492644_1 1100720.ALKN01000028_gene2546 7.07e-25 99.8 COG0625@1|root,COG0625@2|Bacteria,1RAP2@1224|Proteobacteria,2VQGV@28216|Betaproteobacteria,4AD2P@80864|Comamonadaceae 28216|Betaproteobacteria O Glutathione S-transferase - - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C_2,GST_N_3 k59_492644_2 365046.Rta_23870 5.08e-68 214.0 COG4221@1|root,COG4221@2|Bacteria,1MW86@1224|Proteobacteria,2VP8F@28216|Betaproteobacteria,4AD6N@80864|Comamonadaceae 28216|Betaproteobacteria S KR domain - - - - - - - - - - - - adh_short k59_663034_1 1123355.JHYO01000001_gene3226 9.02e-53 183.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,2TU21@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG1014 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, gamma subunit - - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N,Transketolase_C k59_1217467_1 557436.Lreu_0861 2.63e-05 50.8 COG1070@1|root,COG1070@2|Bacteria,1TQ1I@1239|Firmicutes,4H9W6@91061|Bacilli,3F4R2@33958|Lactobacillaceae 91061|Bacilli G Belongs to the FGGY kinase family gntK - 2.7.1.12 ko:K00851 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200 - R01737 RC00002,RC00017 ko00000,ko00001,ko01000 - - - FGGY_C,FGGY_N k59_277261_1 1163617.SCD_n02122 7.51e-25 99.0 COG4968@1|root,COG4968@2|Bacteria,1MZZW@1224|Proteobacteria,2VU8H@28216|Betaproteobacteria 28216|Betaproteobacteria NU Tfp pilus assembly protein - - - ko:K02655 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - ComP_DUS,N_methyl k59_277261_2 1123487.KB892846_gene556 2e-07 54.3 COG4970@1|root,COG4970@2|Bacteria,1NA9B@1224|Proteobacteria,2VV1S@28216|Betaproteobacteria,2KX8W@206389|Rhodocyclales 206389|Rhodocyclales NU Type II transport protein GspH - - - ko:K08084 - - - - ko00000,ko02044 3.A.15.2 - - GspH,N_methyl k59_830395_1 1229909.NSED_07185 1.06e-36 130.0 COG0189@1|root,arCOG01589@2157|Archaea,41SE8@651137|Thaumarchaeota 651137|Thaumarchaeota H Lysine biosynthesis - - 6.3.2.43 ko:K05827 ko00300,ko01100,ko01210,ko01230,map00300,map01100,map01210,map01230 M00031 R09775 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - RimK k59_830395_2 436308.Nmar_1296 5.69e-54 179.0 COG0624@1|root,arCOG01107@2157|Archaea,41SAX@651137|Thaumarchaeota 651137|Thaumarchaeota E Catalyzes the release of L-lysine from LysW -gamma-L- lysine and the release of L-ornithine from LysW -L-ornithine lysK - - ko:K05831 ko00220,ko00300,ko01100,ko01210,ko01230,map00220,map00300,map01100,map01210,map01230 M00031,M00763 R09779,R10933 RC00064,RC00090 ko00000,ko00001,ko00002 - - - M20_dimer,Peptidase_M20 k59_830405_1 555779.Dthio_PD2814 1.15e-58 191.0 COG1830@1|root,COG1830@2|Bacteria,1MW9N@1224|Proteobacteria,42PEB@68525|delta/epsilon subdivisions,2WM0Y@28221|Deltaproteobacteria,2M98D@213115|Desulfovibrionales 28221|Deltaproteobacteria G PFAM deoxyribose-phosphate aldolase phospho-2-dehydro-3-deoxyheptonate aldolase fbaB - 4.1.2.13 ko:K11645 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - DeoC k59_1003993_1 225937.HP15_3878 3.54e-52 185.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,464AK@72275|Alteromonadaceae 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_795224_1 596320.NEIFL0001_2075 8.11e-16 77.8 COG2890@1|root,COG2890@2|Bacteria,1MXCQ@1224|Proteobacteria,2VP72@28216|Betaproteobacteria,2KPF5@206351|Neisseriales 206351|Neisseriales J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif prmC - 2.1.1.297 ko:K02493 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03012 - - - MTS,Methyltransf_31 k59_795224_2 1123393.KB891316_gene1859 2.07e-29 113.0 COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,2VJKV@28216|Betaproteobacteria,1KS94@119069|Hydrogenophilales 119069|Hydrogenophilales J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_873424_1 930169.B5T_00756 2.33e-57 200.0 COG4774@1|root,COG4774@2|Bacteria,1MVZD@1224|Proteobacteria,1RN2P@1236|Gammaproteobacteria,1XNNZ@135619|Oceanospirillales 1236|Gammaproteobacteria P Secretin and TonB N terminus short domain - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,STN,TonB_dep_Rec k59_1052455_1 1380394.JADL01000009_gene3231 5.1e-63 203.0 COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,2TSKF@28211|Alphaproteobacteria,2JPW9@204441|Rhodospirillales 204441|Rhodospirillales H Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) pdxA - 1.1.1.262 ko:K00097 ko00750,ko01100,map00750,map01100 M00124 R05681,R05837,R07406 RC00089,RC00675,RC01475 ko00000,ko00001,ko00002,ko01000 - - - PdxA k59_961630_1 765912.Thimo_2522 1.24e-55 187.0 2C2F5@1|root,32WND@2|Bacteria,1ND6R@1224|Proteobacteria,1RSN5@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_194386_1 497321.C664_11330 2.29e-60 192.0 COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,2VH29@28216|Betaproteobacteria,2KUNS@206389|Rhodocyclales 206389|Rhodocyclales S ABC-type (Unclassified) transport system, ATPase component - - - ko:K06861 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko01000,ko02000 1.B.42.1 - - ABC_tran,BCA_ABC_TP_C k59_1260311_2 395019.Bmul_0868 9.15e-96 308.0 COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,2VI9F@28216|Betaproteobacteria,1K3WM@119060|Burkholderiaceae 28216|Betaproteobacteria H Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle ppc - 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPcase k59_1349646_2 1121396.KB893081_gene1736 6.35e-17 84.7 COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,42MG2@68525|delta/epsilon subdivisions,2WJ01@28221|Deltaproteobacteria,2MIUK@213118|Desulfobacterales 28221|Deltaproteobacteria D Belongs to the SEDS family ftsW - - ko:K03588 ko04112,map04112 - - - ko00000,ko00001,ko02000,ko03036 2.A.103.1 - - FTSW_RODA_SPOVE k59_575730_1 1423144.Gal_03052 8.29e-86 281.0 COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2TSHH@28211|Alphaproteobacteria,34E6T@302485|Phaeobacter 28211|Alphaproteobacteria C Pyruvate ferredoxin/flavodoxin oxidoreductase MA20_06130 - 1.2.7.8 ko:K04090 - - - - br01601,ko00000,ko01000 - - - POR,TPP_enzyme_C k59_706054_1 1437448.AZRT01000037_gene3199 1.92e-93 289.0 COG0129@1|root,COG0129@2|Bacteria,1MV4I@1224|Proteobacteria,2TQRW@28211|Alphaproteobacteria,1J3VD@118882|Brucellaceae 28211|Alphaproteobacteria EG Dehydratase family MA20_39205 - 4.2.1.82,4.2.1.9 ko:K01687,ko:K22186 ko00040,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00040,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R02429,R04441,R05070 RC00468,RC00543,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_1004112_1 1150469.RSPPHO_01106 1.34e-38 146.0 COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,2TSJ3@28211|Alphaproteobacteria,2JQQD@204441|Rhodospirillales 204441|Rhodospirillales O Chaperone SurA surA - 5.2.1.8 ko:K03771 - - - - ko00000,ko01000,ko03110 - - - Rotamase,SurA_N,SurA_N_3 k59_149370_1 292415.Tbd_2587 4.02e-69 222.0 COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,2VI4X@28216|Betaproteobacteria,1KRF7@119069|Hydrogenophilales 119069|Hydrogenophilales H DNA / pantothenate metabolism flavoprotein - - 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - - DFP,Flavoprotein k59_1260341_1 1454004.AW11_00972 6.74e-85 279.0 COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,2VHHQ@28216|Betaproteobacteria,1KQ8R@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria Q FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_71156_1 1033802.SSPSH_002016 4.75e-89 278.0 COG0517@1|root,COG0538@1|root,COG0517@2|Bacteria,COG0538@2|Bacteria,1MW3J@1224|Proteobacteria,1RNMD@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Isocitrate dehydrogenase icd GO:0003674,GO:0003824,GO:0004448,GO:0004450,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0022900,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0055114 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - e_coli_core.b1136,iAF1260.b1136,iECDH1ME8569_1439.ECDH1ME8569_1071,iEcDH1_1363.EcDH1_2511,iJN746.PP_4011,iJO1366.b1136,iJR904.b1136,iY75_1357.Y75_RS05930,iYL1228.KPN_01144 Iso_dh k59_107057_1 1089551.KE386572_gene664 1.12e-97 297.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,2TT2J@28211|Alphaproteobacteria,4BP5Z@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria P Ammonium Transporter Family amtB - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_277508_1 1123360.thalar_02887 6.87e-15 75.5 COG1999@1|root,COG1999@2|Bacteria 2|Bacteria M signal sequence binding sco - - ko:K07152 - - - - ko00000,ko03029 - - - SCO1-SenC k59_277508_2 1437824.BN940_02376 1.52e-23 100.0 COG0543@1|root,COG1018@1|root,COG1290@1|root,COG0543@2|Bacteria,COG1018@2|Bacteria,COG1290@2|Bacteria,1MV72@1224|Proteobacteria,2VI9K@28216|Betaproteobacteria,3T1JD@506|Alcaligenaceae 28216|Betaproteobacteria C Catalyzes the formation of 3,6-dideoxy-D-glycero-D-glycero-4-hexulose ascD - 1.17.1.1 ko:K00523 ko00520,map00520 - R03391,R03392 RC00230 ko00000,ko00001,ko01000 - - - FAD_binding_6,Fer2,NAD_binding_1 k59_961732_1 314278.NB231_01149 6.12e-16 76.3 COG1159@1|root,COG1159@2|Bacteria,1MUKT@1224|Proteobacteria,1RN3A@1236|Gammaproteobacteria,1WW0G@135613|Chromatiales 135613|Chromatiales J An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism era - - ko:K03595 - - - - ko00000,ko03009,ko03029 - - - KH_2,MMR_HSR1 k59_961732_2 1454004.AW11_03071 5.04e-30 114.0 COG0571@1|root,COG0571@2|Bacteria,1MUQ6@1224|Proteobacteria,2VI4M@28216|Betaproteobacteria,1KPXB@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism rnc GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 ko:K03685 ko03008,ko05205,map03008,map05205 - - - ko00000,ko00001,ko01000,ko03009,ko03019,ko03036 - - - Ribonucleas_3_3,dsrm k59_1052594_1 420662.Mpe_A3247 6.46e-107 319.0 COG2070@1|root,COG2070@2|Bacteria,1MU2F@1224|Proteobacteria,2VJ5B@28216|Betaproteobacteria,1KKE9@119065|unclassified Burkholderiales 28216|Betaproteobacteria S 2-nitropropane dioxygenase - - 1.13.12.16 ko:K00459 ko00910,map00910 - R00025 RC02541,RC02759 ko00000,ko00001,ko01000 - - - NMO k59_194492_1 1096546.WYO_1835 3.76e-99 296.0 COG1878@1|root,COG1878@2|Bacteria,1MWWB@1224|Proteobacteria,2TSIG@28211|Alphaproteobacteria,1JT9Y@119045|Methylobacteriaceae 28211|Alphaproteobacteria S Putative cyclase - - - - - - - - - - - - Cyclase,TAT_signal k59_242880_1 1120946.AUBF01000013_gene998 1.42e-33 126.0 COG1013@1|root,COG1013@2|Bacteria,2HJSP@201174|Actinobacteria,4D43C@85005|Actinomycetales 201174|Actinobacteria C Thiamine pyrophosphate enzyme, C-terminal TPP binding domain protein porB - 1.2.7.1 ko:K00170 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C k59_242880_2 395494.Galf_0059 3.49e-148 432.0 COG0493@1|root,COG1144@1|root,COG0493@2|Bacteria,COG1144@2|Bacteria,1MU2H@1224|Proteobacteria,2VM9R@28216|Betaproteobacteria,44V9S@713636|Nitrosomonadales 28216|Betaproteobacteria C Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - - - - - - - - - - Fer4,Fer4_20,Fer4_21,Pyr_redox_2,Pyr_redox_3 k59_242882_1 1528106.JRJE01000008_gene1567 4.72e-68 216.0 COG0451@1|root,COG0451@2|Bacteria,1MVE4@1224|Proteobacteria,2TQJI@28211|Alphaproteobacteria,2JR70@204441|Rhodospirillales 204441|Rhodospirillales G Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose hldD - 5.1.3.20 ko:K03274 ko00540,ko01100,map00540,map01100 M00064 R05176 RC01291 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Epimerase k59_753967_1 1249634.D781_3819 7.83e-14 70.1 COG0235@1|root,COG0235@2|Bacteria,1MWP9@1224|Proteobacteria,1RQNI@1236|Gammaproteobacteria 1236|Gammaproteobacteria G COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases - - - - - - - - - - - - Aldolase_II k59_753967_2 1208321.D104_09310 4.72e-17 83.2 COG0042@1|root,COG0042@2|Bacteria,1MUY1@1224|Proteobacteria,1RN28@1236|Gammaproteobacteria,1XI2R@135619|Oceanospirillales 135619|Oceanospirillales J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs dusA - - ko:K05539 - - - - ko00000,ko01000,ko03016 - - - Dus k59_331105_1 864051.BurJ1DRAFT_3014 1.07e-12 67.4 COG3146@1|root,COG3146@2|Bacteria,1MU35@1224|Proteobacteria,2VH0Z@28216|Betaproteobacteria,1KIYB@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Peptidogalycan biosysnthesis/recognition - - - ko:K09919 - - - - ko00000 - - - FemAB_like k59_581146_2 748247.AZKH_1286 4.67e-27 107.0 COG3005@1|root,COG3005@2|Bacteria,1R4UP@1224|Proteobacteria,2VM47@28216|Betaproteobacteria,2KUB7@206389|Rhodocyclales 206389|Rhodocyclales C Cytochrome c554 and c-prime - - - - - - - - - - - - Paired_CXXCH_1 k59_835227_1 359.CN09_34045 1.51e-73 232.0 COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,2TRZ1@28211|Alphaproteobacteria,4B9J9@82115|Rhizobiaceae 28211|Alphaproteobacteria O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_1180338_1 335543.Sfum_0007 2.76e-33 130.0 COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,42MDB@68525|delta/epsilon subdivisions,2WITV@28221|Deltaproteobacteria,2MQZD@213462|Syntrophobacterales 28221|Deltaproteobacteria F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF - 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase_6,GATase_7,Pribosyltran k59_878340_1 880073.Calab_1874 2.5e-68 225.0 COG0481@1|root,COG0481@2|Bacteria,2NNXG@2323|unclassified Bacteria 2|Bacteria M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner lepA - - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C k59_154775_1 1218074.BAXZ01000023_gene4305 2.64e-22 96.7 COG0412@1|root,COG0412@2|Bacteria,1QZFP@1224|Proteobacteria,2WHKY@28216|Betaproteobacteria,1KHC8@119060|Burkholderiaceae 28216|Betaproteobacteria Q Dienelactone hydrolase - - - - - - - - - - - - - k59_154775_2 67257.JODR01000002_gene1277 1.86e-40 147.0 COG0656@1|root,COG2197@1|root,COG0656@2|Bacteria,COG2197@2|Bacteria,2GM61@201174|Actinobacteria 201174|Actinobacteria T response regulator - - - - - - - - - - - - GerE,Response_reg k59_1009449_1 1220601.L7TLW2_9CAUD 1.1e-50 182.0 4QASG@10239|Viruses,4QZZU@35237|dsDNA viruses no RNA stage,4QT37@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_1133756_1 465817.ETA_15450 3.06e-58 194.0 COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,1RM8U@1236|Gammaproteobacteria,3X539@551|Erwinia 1236|Gammaproteobacteria M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids dadX - 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 - R00401 RC00285 ko00000,ko00001,ko01000,ko01011 - - iEC55989_1330.EC55989_1285,iECIAI39_1322.ECIAI39_1880,iECO103_1326.ECO103_1292,iECO26_1355.ECO26_1703,iECSE_1348.ECSE_1238,iECUMN_1333.ECUMN_1479,iECW_1372.ECW_m1275,iEKO11_1354.EKO11_2666,iEcE24377_1341.EcE24377A_1335,iWFL_1372.ECW_m1275,iYL1228.KPN_02308 Ala_racemase_C,Ala_racemase_N k59_1265707_2 521719.ATXQ01000001_gene633 1.37e-43 147.0 COG3223@1|root,COG3223@2|Bacteria,1RD8R@1224|Proteobacteria,1S4FE@1236|Gammaproteobacteria,1YFWV@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S Phosphate-starvation-inducible E psiE GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K13256 - - - - ko00000 - - - PsiE k59_455752_1 1384054.N790_04365 3.16e-33 119.0 COG2335@1|root,COG2335@2|Bacteria,1RD06@1224|Proteobacteria,1RSMY@1236|Gammaproteobacteria,1X6JY@135614|Xanthomonadales 135614|Xanthomonadales M Four repeated domains in the Fasciclin I family of proteins, present in many other contexts. - - - - - - - - - - - - Fasciclin k59_669455_1 502025.Hoch_6118 1.95e-47 164.0 COG1262@1|root,COG1262@2|Bacteria,1MUNC@1224|Proteobacteria,42N4Y@68525|delta/epsilon subdivisions,2WKGT@28221|Deltaproteobacteria,2YXYB@29|Myxococcales 28221|Deltaproteobacteria S DinB superfamily - - 1.14.99.50 ko:K18912 ko00340,map00340 - R11013 RC03323,RC03324 ko00000,ko00001,ko01000 - - - DinB_2,FGE-sulfatase,Methyltransf_31 k59_669455_2 883080.HMPREF9697_00152 6.36e-21 90.9 COG4301@1|root,COG4301@2|Bacteria,1MUCG@1224|Proteobacteria,2TRMH@28211|Alphaproteobacteria,3JRIF@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Histidine-specific methyltransferase, SAM-dependent MA20_09135 - - - - - - - - - - - Methyltransf_33 k59_1041837_1 42565.FP66_03835 8.95e-53 186.0 COG0398@1|root,COG1249@1|root,COG0398@2|Bacteria,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RQTU@1236|Gammaproteobacteria,1XHNV@135619|Oceanospirillales 135619|Oceanospirillales C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family - - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim,SNARE_assoc k59_1208696_1 686578.AFFX01000005_gene4280 2.02e-49 171.0 COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,1RMR2@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate glmM - 5.4.2.10 ko:K03431 ko00520,ko01100,ko01130,map00520,map01100,map01130 - R02060 RC00408 ko00000,ko00001,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_1208696_2 225937.HP15_3073 0.000191 43.5 COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,1RM8G@1236|Gammaproteobacteria,4642K@72275|Alteromonadaceae 1236|Gammaproteobacteria H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives folP GO:0003674,GO:0003824,GO:0004156,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042221,GO:0042364,GO:0042398,GO:0042493,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046655,GO:0046656,GO:0050896,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.15 ko:K00796 ko00790,ko01100,map00790,map01100 M00126,M00841 R03066,R03067 RC00121,RC00842 ko00000,ko00001,ko00002,ko01000 - - iECO103_1326.ECO103_3924,iPC815.YPO3501 Pterin_bind k59_269240_1 395495.Lcho_3732 1.04e-62 215.0 COG1148@1|root,COG1148@2|Bacteria,1QUQG@1224|Proteobacteria,2VMBE@28216|Betaproteobacteria,1KJCC@119065|unclassified Burkholderiales 28216|Betaproteobacteria C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4,Fer4_4,Fer4_6,Fer4_7 k59_865738_1 679191.HMPREF9018_1622 3.21e-29 114.0 COG1028@1|root,COG1028@2|Bacteria,4NFTU@976|Bacteroidetes,2FQMI@200643|Bacteroidia 976|Bacteroidetes IQ Oxidoreductase, short chain dehydrogenase reductase family protein fabG3 - 1.1.1.100,1.1.1.36 ko:K00023,ko:K00059 ko00061,ko00333,ko00630,ko00650,ko00780,ko01040,ko01100,ko01120,ko01130,ko01200,ko01212,map00061,map00333,map00630,map00650,map00780,map01040,map01100,map01120,map01130,map01200,map01212 M00083,M00373,M00572 R01779,R01977,R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00103,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_654203_1 1047013.AQSP01000121_gene2703 7.9e-20 83.2 2DMHR@1|root,32RMI@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_269243_1 1207063.P24_07146 3.33e-51 171.0 COG1525@1|root,COG1525@2|Bacteria,1R3VA@1224|Proteobacteria,2U0NK@28211|Alphaproteobacteria,2JS0I@204441|Rhodospirillales 204441|Rhodospirillales L Staphylococcal nuclease homologue - - - - - - - - - - - - SNase k59_359048_1 76114.ebA6426 1.28e-202 584.0 COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,2VKSY@28216|Betaproteobacteria,2KVC6@206389|Rhodocyclales 206389|Rhodocyclales C Molybdopterin oxidoreductase Fe4S4 domain - - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal k59_952853_2 522306.CAP2UW1_4224 2.89e-33 119.0 COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,2VSP6@28216|Betaproteobacteria,1KQ3V@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria M Belongs to the ompA family pal - - ko:K03640 - - - - ko00000,ko02000 2.C.1.2 - - OmpA k59_822933_1 1245469.S58_27820 2.58e-63 205.0 COG0523@1|root,COG0523@2|Bacteria,1MVZV@1224|Proteobacteria,2TQWN@28211|Alphaproteobacteria,3JRFY@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S cobalamin synthesis protein cobW - - ko:K02234 - - - - ko00000,ko00001 - - - CobW_C,cobW k59_822933_2 1380391.JIAS01000012_gene4276 6.22e-08 53.1 COG1429@1|root,COG1429@2|Bacteria,1MU5W@1224|Proteobacteria,2TQVD@28211|Alphaproteobacteria,2JQI4@204441|Rhodospirillales 204441|Rhodospirillales H COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatases cobN - 6.6.1.2 ko:K02230 ko00860,ko01100,map00860,map01100 - R05227 RC02000 ko00000,ko00001,ko01000 - - - CobN-Mg_chel k59_398603_1 1216976.AX27061_1545 5.65e-28 114.0 COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,2VHP1@28216|Betaproteobacteria,3T6RQ@506|Alcaligenaceae 28216|Betaproteobacteria C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) aceE1 GO:0000287,GO:0003674,GO:0003824,GO:0004738,GO:0005488,GO:0005515,GO:0008150,GO:0008152,GO:0016491,GO:0016903,GO:0019842,GO:0030976,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0046872,GO:0046983,GO:0048037,GO:0050662,GO:0055114,GO:0097159,GO:1901363,GO:1901681 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transketolase_C,Transketolase_N k59_1041978_1 426355.Mrad2831_4526 1.14e-12 65.9 COG0262@1|root,COG0262@2|Bacteria,1RH0P@1224|Proteobacteria,2U9GC@28211|Alphaproteobacteria,1JSUP@119045|Methylobacteriaceae 28211|Alphaproteobacteria H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis folA - 1.5.1.3 ko:K00287 ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523 M00126,M00840 R00936,R00937,R00939,R00940,R02235,R02236,R11765 RC00109,RC00110,RC00158 ko00000,ko00001,ko00002,ko01000 - - - DHFR_1 k59_1041978_2 1288494.EBAPG3_13140 1.95e-68 218.0 COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,2VI3M@28216|Betaproteobacteria,372I8@32003|Nitrosomonadales 28216|Betaproteobacteria E Belongs to the Orn Lys Arg decarboxylase class-II family - - 4.1.1.17 ko:K01581 ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130 M00134 R00670 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_865812_1 1028307.EAE_11890 2.66e-45 161.0 COG1726@1|root,COG1726@2|Bacteria,1MU36@1224|Proteobacteria,1RPU1@1236|Gammaproteobacteria,3X31C@547|Enterobacter 1236|Gammaproteobacteria C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol nqrA GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008137,GO:0008150,GO:0008152,GO:0015672,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030001,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0051179,GO:0051234,GO:0055114,GO:0098796,GO:1902494 1.6.5.8 ko:K00346 - - - - ko00000,ko01000 - - - NQRA,NQRA_SLBB k59_1208815_1 1562701.BBOF01000048_gene1344 2.53e-94 293.0 COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,2VHKQ@28216|Betaproteobacteria,1K0F2@119060|Burkholderiaceae 28216|Betaproteobacteria J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) aspS - 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GAD,tRNA-synt_2,tRNA_anti-codon k59_1121387_1 85643.Tmz1t_1763 1.51e-36 133.0 COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,2VKF3@28216|Betaproteobacteria,2KVQ8@206389|Rhodocyclales 206389|Rhodocyclales K COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases crp - - ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - HTH_Crp_2,cNMP_binding k59_1339558_1 331869.BAL199_12961 8.56e-91 276.0 COG1893@1|root,COG1893@2|Bacteria,1P0AW@1224|Proteobacteria,2VEXI@28211|Alphaproteobacteria,4BS72@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid - - 1.1.1.169 ko:K00077 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R02472 RC00726 ko00000,ko00001,ko00002,ko01000 - - - ApbA,ApbA_C k59_141302_1 391038.Bphy_2359 3.34e-103 307.0 COG0604@1|root,COG0604@2|Bacteria,1R8NX@1224|Proteobacteria,2W0KY@28216|Betaproteobacteria,1K4PK@119060|Burkholderiaceae 28216|Betaproteobacteria C Alcohol dehydrogenase GroES-like domain - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N_2 k59_359154_1 1123060.JONP01000032_gene1866 4.54e-23 96.7 COG2084@1|root,COG2084@2|Bacteria,1PU4S@1224|Proteobacteria,2TT0X@28211|Alphaproteobacteria 28211|Alphaproteobacteria I COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid - - 1.1.1.31 ko:K00020 ko00280,ko01100,map00280,map01100 - R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_359154_2 1502852.FG94_01033 1.17e-40 143.0 COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,2VKFT@28216|Betaproteobacteria 28216|Betaproteobacteria KT response regulator - - - - - - - - - - - - LytTR,Response_reg k59_317208_1 991905.SL003B_4075 1.33e-92 286.0 COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria 1224|Proteobacteria L PFAM Integrase catalytic - - - - - - - - - - - - HTH_23,HTH_38,HTH_7,rve k59_785480_1 1121015.N789_08290 2.46e-62 209.0 COG4579@1|root,COG4579@2|Bacteria,1MVRB@1224|Proteobacteria,1RMC2@1236|Gammaproteobacteria,1X3M4@135614|Xanthomonadales 135614|Xanthomonadales F Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation aceK GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0004721,GO:0005488,GO:0005524,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008772,GO:0009987,GO:0016208,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016787,GO:0016788,GO:0016791,GO:0017076,GO:0018105,GO:0018193,GO:0018209,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0042578,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050790,GO:0065007,GO:0065009,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 2.7.11.5 ko:K00906 - - - - ko00000,ko01000 - - - AceK k59_785484_1 420324.KI911965_gene556 5.61e-17 78.6 COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2TR61@28211|Alphaproteobacteria,1JTCI@119045|Methylobacteriaceae 28211|Alphaproteobacteria E ATPases associated with a variety of cellular activities - - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran k59_785484_2 1316936.K678_04226 4.24e-72 225.0 COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2TQK1@28211|Alphaproteobacteria,2JR23@204441|Rhodospirillales 204441|Rhodospirillales E branched-chain amino acid transport - - - ko:K01995,ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C,BPD_transp_2 k59_61128_1 266264.Rmet_1854 8.03e-90 269.0 COG1335@1|root,COG1335@2|Bacteria,1MUGW@1224|Proteobacteria,2VIMK@28216|Betaproteobacteria,1JZX0@119060|Burkholderiaceae 28216|Betaproteobacteria Q Nicotinamidase pncA - 3.5.1.19 ko:K08281 ko00760,ko01100,map00760,map01100 - R01268 RC00100 ko00000,ko00001,ko01000 - - - Isochorismatase k59_61128_2 1226994.AMZB01000110_gene2004 4.33e-27 113.0 COG0583@1|root,COG0583@2|Bacteria,1R43D@1224|Proteobacteria,1S33J@1236|Gammaproteobacteria,1YDVV@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_61134_1 1049564.TevJSym_al00220 3.28e-56 189.0 28I6N@1|root,2Z89J@2|Bacteria,1MUVT@1224|Proteobacteria,1RQUY@1236|Gammaproteobacteria,1J7IW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1042100_1 635013.TherJR_2836 1.88e-06 55.1 COG0392@1|root,COG0392@2|Bacteria,1VD4Q@1239|Firmicutes,24XDX@186801|Clostridia,263AA@186807|Peptococcaceae 186801|Clostridia S Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms - - - - - - - - - - - - LPG_synthase_TM k59_1339664_1 89187.ISM_10980 3.36e-35 131.0 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQNK@28211|Alphaproteobacteria,46PMC@74030|Roseovarius 28211|Alphaproteobacteria G COG1593 TRAP-type C4-dicarboxylate transport system, large permease component - - - - - - - - - - - - DctM k59_1339664_2 1294273.roselon_03596 4.46e-06 48.9 COG3090@1|root,COG3090@2|Bacteria,1N9D4@1224|Proteobacteria,2U96V@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Tripartite ATP-independent periplasmic transporters, DctQ component - - - - - - - - - - - - DctQ k59_1166230_1 296591.Bpro_2564 2e-85 271.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2VHMA@28216|Betaproteobacteria,4A9UE@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM acyl-CoA dehydrogenase domain protein aidB - - ko:K09456 - - - - ko00000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M k59_398740_1 1380355.JNIJ01000006_gene3041 7.02e-153 440.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,3JR1M@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L PFAM transposase IS116 IS110 IS902 family - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_1293493_1 1123366.TH3_21549 6.58e-16 76.6 COG3712@1|root,COG3712@2|Bacteria,1MZCK@1224|Proteobacteria,2U7GV@28211|Alphaproteobacteria,2JYMS@204441|Rhodospirillales 204441|Rhodospirillales PT Two component sensor histidine kinase FecR PupR - - - ko:K07165 - - - - ko00000 - - - DUF4880,FecR k59_317333_1 338969.Rfer_2156 4.64e-103 339.0 COG1640@1|root,COG3280@1|root,COG1640@2|Bacteria,COG3280@2|Bacteria,1QTVJ@1224|Proteobacteria,2WGPV@28216|Betaproteobacteria,4AD3R@80864|Comamonadaceae 28216|Betaproteobacteria G SMART alpha amylase catalytic sub domain treY - 2.4.1.25,5.4.99.15 ko:K00705,ko:K06044 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R01824,R05196,R09995 RC00049 ko00000,ko00001,ko00002,ko01000 - GH13,GH77 - Alpha-amylase,Glyco_hydro_77 k59_953041_1 864069.MicloDRAFT_00055900 9.86e-94 285.0 COG0683@1|root,COG0683@2|Bacteria,1MXR4@1224|Proteobacteria,2TU0F@28211|Alphaproteobacteria,1JV9N@119045|Methylobacteriaceae 28211|Alphaproteobacteria E Receptor family ligand binding region - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_185864_2 1479238.JQMZ01000001_gene1073 7.17e-43 147.0 COG0727@1|root,COG0727@2|Bacteria,1NPRE@1224|Proteobacteria,2UT7P@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Putative zinc- or iron-chelating domain - - - - - - - - - - - - CxxCxxCC k59_567762_3 1037409.BJ6T_12300 6.89e-44 150.0 COG2606@1|root,COG2606@2|Bacteria,1N10Y@1224|Proteobacteria,2U57Q@28211|Alphaproteobacteria,3JVX5@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Aminoacyl-tRNA editing domain - - - ko:K19055 - - - - ko00000,ko01000,ko03016 - - - tRNA_edit k59_1042189_1 1121877.JQKF01000004_gene1062 2.4e-16 78.2 COG0464@1|root,COG0464@2|Bacteria,2GJWA@201174|Actinobacteria,4CNTH@84992|Acidimicrobiia 84992|Acidimicrobiia O ATPase family associated with various cellular activities (AAA) - - - - - - - - - - - - AAA k59_1042189_2 321332.CYB_0748 2.23e-51 172.0 COG0637@1|root,COG0637@2|Bacteria,1G2T2@1117|Cyanobacteria,1GZ2D@1129|Synechococcus 1117|Cyanobacteria S HAD-superfamily hydrolase subfamily IA, variant 3 - - - - - - - - - - - - HAD_2 k59_823114_1 159087.Daro_3080 2.22e-51 174.0 COG0795@1|root,COG0795@2|Bacteria,1MVW3@1224|Proteobacteria,2VHA1@28216|Betaproteobacteria,2KUBZ@206389|Rhodocyclales 206389|Rhodocyclales S Permease YjgP YjgQ family - - - ko:K11720 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_145136_2 237609.PSAKL28_32070 8.4e-07 50.1 COG5500@1|root,COG5500@2|Bacteria,1N0PP@1224|Proteobacteria,1SIS0@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF1772) - - - - - - - - - - - - DUF1772 k59_914873_1 1071679.BG57_29510 1.68e-139 410.0 COG2721@1|root,COG2721@2|Bacteria,1MU9V@1224|Proteobacteria,2VHJB@28216|Betaproteobacteria,1K0EB@119060|Burkholderiaceae 28216|Betaproteobacteria G PFAM D-galactarate dehydratase Altronate hydrolase domain protein garD - 4.2.1.7,4.4.1.24 ko:K01685,ko:K16846 ko00040,ko00270,ko01100,map00040,map00270,map01100 M00631 R01540,R07633 RC00543,RC01785 ko00000,ko00001,ko00002,ko01000 - - - GD_AH_C,SAF k59_744307_1 272942.RCAP_rcc01241 2.49e-16 76.6 COG0321@1|root,COG0321@2|Bacteria,1MU6A@1224|Proteobacteria,2TRXJ@28211|Alphaproteobacteria,1FB5J@1060|Rhodobacter 28211|Alphaproteobacteria H Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate lipB GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564 2.3.1.181 ko:K03801 ko00785,ko01100,map00785,map01100 - R07766,R07769 RC00039,RC00992,RC02867 ko00000,ko00001,ko01000 - - - BPL_LplA_LipB k59_1297518_1 1173264.KI913949_gene2157 1.66e-18 87.4 COG0841@1|root,COG0841@2|Bacteria,1G0C2@1117|Cyanobacteria,1H75B@1150|Oscillatoriales 1117|Cyanobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_1297518_2 580332.Slit_2618 1.21e-14 80.5 COG0845@1|root,COG0845@2|Bacteria,1NQZ0@1224|Proteobacteria,2VJAC@28216|Betaproteobacteria,44VMF@713636|Nitrosomonadales 28216|Betaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_D23 k59_571528_1 395494.Galf_2858 8.64e-47 168.0 COG1807@1|root,COG1807@2|Bacteria,1P6JE@1224|Proteobacteria,2VJS8@28216|Betaproteobacteria 28216|Betaproteobacteria M Dolichyl-phosphate-mannose-protein mannosyltransferase - - - - - - - - - - - - PMT_2 k59_957345_1 582744.Msip34_0969 1.01e-78 239.0 COG1738@1|root,COG1738@2|Bacteria,1NIPE@1224|Proteobacteria,2VH6D@28216|Betaproteobacteria,2KM8N@206350|Nitrosomonadales 206350|Nitrosomonadales S Involved in the import of queuosine (Q) precursors, required for Q precursor salvage - - - ko:K09125 - - - - ko00000 - - - Vut_1 k59_957345_2 164757.Mjls_3758 7.74e-11 65.5 COG2128@1|root,COG2128@2|Bacteria,2IAT6@201174|Actinobacteria,238XY@1762|Mycobacteriaceae 201174|Actinobacteria S carboxymuconolactone decarboxylase - - - - - - - - - - - - CMD k59_957345_3 258594.RPA3778 1.57e-11 64.7 COG2124@1|root,COG2124@2|Bacteria,1MY5H@1224|Proteobacteria,2TTRR@28211|Alphaproteobacteria,3JVM6@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria Q Cytochrome P450 MA20_16830 - - - - - - - - - - - p450 k59_145181_1 1415779.JOMH01000001_gene2901 3.69e-71 246.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1X3KX@135614|Xanthomonadales 135614|Xanthomonadales NT chemotaxis protein - - - - - - - - - - - - MCPsignal,PAS_4,PAS_9 k59_403162_1 1144342.PMI40_01534 6.85e-58 197.0 COG1232@1|root,COG1232@2|Bacteria,1NQUH@1224|Proteobacteria,2VJV1@28216|Betaproteobacteria,472Y4@75682|Oxalobacteraceae 28216|Betaproteobacteria H Flavin containing amine oxidoreductase hpnE - 1.17.8.1 ko:K21677 - - - - ko00000,ko01000 - - - Amino_oxidase k59_914933_1 1384056.N787_13060 6.43e-06 46.6 COG1595@1|root,COG1595@2|Bacteria,1N38X@1224|Proteobacteria,1S8HN@1236|Gammaproteobacteria,1X62E@135614|Xanthomonadales 135614|Xanthomonadales K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4,Sigma70_r4_2 k59_914933_2 1121015.N789_13455 1.42e-21 94.4 2A20V@1|root,30QAU@2|Bacteria,1RDQH@1224|Proteobacteria,1T055@1236|Gammaproteobacteria,1X6SQ@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - - k59_999893_2 365046.Rta_23910 3.04e-21 94.4 2DNXC@1|root,32ZN4@2|Bacteria,1NKWP@1224|Proteobacteria,2VX7B@28216|Betaproteobacteria,4AFCK@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_620964_1 671143.DAMO_2712 2.84e-42 140.0 COG0838@1|root,COG0838@2|Bacteria,2NPTW@2323|unclassified Bacteria 2|Bacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoA GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0055114,GO:0098796,GO:1902494 1.6.5.3 ko:K00330,ko:K05574 ko00190,ko01100,map00190,map01100 M00144,M00145 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q4 k59_403195_1 1304883.KI912532_gene2125 2.68e-09 57.4 COG4105@1|root,COG4105@2|Bacteria,1MVS5@1224|Proteobacteria,2VH6I@28216|Betaproteobacteria,2KUN1@206389|Rhodocyclales 206389|Rhodocyclales M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamD - - ko:K05807 - - - - ko00000,ko02000 1.B.33.1 - - YfiO k59_403195_2 1144319.PMI16_00295 3.23e-32 122.0 COG0451@1|root,COG0451@2|Bacteria,1MU1A@1224|Proteobacteria,2VHGA@28216|Betaproteobacteria,472GQ@75682|Oxalobacteraceae 28216|Betaproteobacteria M Male sterility protein - - 1.1.1.410 ko:K22025 - - - - ko00000,ko01000 - - - Epimerase k59_869724_1 272134.KB731324_gene988 9.04e-29 114.0 2B73M@1|root,3204M@2|Bacteria,1GIC7@1117|Cyanobacteria,1HGBG@1150|Oscillatoriales 1117|Cyanobacteria S Methyltransferase domain - - - - - - - - - - - - Methyltransf_21 k59_531329_1 1288826.MSNKSG1_04621 6.98e-67 213.0 COG2220@1|root,COG2220@2|Bacteria,1R5GU@1224|Proteobacteria,1SIPM@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Zn-dependent hydrolases of the beta-lactamase fold - - - - - - - - - - - - Lactamase_B_3 k59_403225_1 1408224.SAMCCGM7_c5467 2.82e-50 179.0 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4B9BA@82115|Rhizobiaceae 28211|Alphaproteobacteria T Adenylate cyclase cyaF - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_cyc,TPR_16,TPR_19,TPR_2,TPR_8 k59_531363_1 76114.ebA5735 1.41e-23 100.0 COG1524@1|root,COG1524@2|Bacteria,1R2II@1224|Proteobacteria,2VMR9@28216|Betaproteobacteria,2KW7I@206389|Rhodocyclales 206389|Rhodocyclales S type I phosphodiesterase nucleotide pyrophosphatase - - - - - - - - - - - - Phosphodiest k59_531363_2 266265.Bxe_B0595 3.24e-37 135.0 COG2267@1|root,COG2267@2|Bacteria,1MX0N@1224|Proteobacteria,2WHBS@28216|Betaproteobacteria,1KIKH@119060|Burkholderiaceae 28216|Betaproteobacteria I Alpha/beta hydrolase family - - 3.1.1.24 ko:K01055 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00568 R02991 RC00825 ko00000,ko00001,ko00002,ko01000 - - - Abhydrolase_1 k59_1256128_1 991.IW20_11255 1.78e-45 169.0 COG0308@1|root,COG0308@2|Bacteria,4NGTZ@976|Bacteroidetes,1HY7M@117743|Flavobacteriia,2NTII@237|Flavobacterium 976|Bacteroidetes E Peptidase family M1 domain pepN - 3.4.11.2 ko:K01256 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - ERAP1_C,Peptidase_M1 k59_1256132_1 1123504.JQKD01000004_gene5027 2.69e-63 204.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VKWF@28216|Betaproteobacteria,4ABZ7@80864|Comamonadaceae 28216|Betaproteobacteria C Acyl-CoA dehydrogenase, C-terminal domain - - 1.3.8.1 ko:K00248 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 - R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1256132_2 391937.NA2_01749 9.15e-13 67.4 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,43GQI@69277|Phyllobacteriaceae 28211|Alphaproteobacteria C CoA-transferase family III - - 2.8.3.16 ko:K07749 - - - - ko00000,ko01000 - - - CoA_transf_3 k59_826886_1 257310.BB3689 1.03e-133 392.0 COG2079@1|root,COG2079@2|Bacteria,1MUIG@1224|Proteobacteria,2VH7T@28216|Betaproteobacteria,3T3BF@506|Alcaligenaceae 28216|Betaproteobacteria S 2-methylcitrate dehydratase prpD - 4.2.1.79 ko:K01720 ko00640,map00640 - R04424 RC01152 ko00000,ko00001,ko01000 - - - MmgE_PrpD k59_403302_1 420324.KI911999_gene8064 3.06e-79 256.0 28JZZ@1|root,2Z9PZ@2|Bacteria,1N3C6@1224|Proteobacteria,2TSCX@28211|Alphaproteobacteria,1JTZB@119045|Methylobacteriaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_145315_1 1238182.C882_0348 3.7e-94 290.0 COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,2JREQ@204441|Rhodospirillales 204441|Rhodospirillales S Tripartite tricarboxylate transporter TctA family - - - - - - - - - - - - TctA k59_1125326_1 1157708.KB907462_gene897 2.41e-106 317.0 COG1398@1|root,COG1398@2|Bacteria,1N2MA@1224|Proteobacteria,2VHRS@28216|Betaproteobacteria,4AB2U@80864|Comamonadaceae 28216|Betaproteobacteria I PFAM fatty acid desaturase - - 1.14.19.1 ko:K00507 ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212 - R02222 RC00917 ko00000,ko00001,ko01000,ko01004 - - - DDE_Tnp_ISL3,FA_desaturase k59_1047616_1 1196028.ALEF01000001_gene1901 7.52e-25 103.0 COG3547@1|root,COG3547@2|Bacteria,1V427@1239|Firmicutes,4HGY6@91061|Bacilli 91061|Bacilli L PFAM transposase IS116 IS110 IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_531429_1 522306.CAP2UW1_2689 1.26e-19 90.5 COG0224@1|root,COG0224@2|Bacteria,1RIE5@1224|Proteobacteria,2VYNF@28216|Betaproteobacteria 28216|Betaproteobacteria C ATP synthase - - - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt k59_364915_1 1236959.BAMT01000007_gene2602 2.45e-70 228.0 COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,2VHIA@28216|Betaproteobacteria,2KM2S@206350|Nitrosomonadales 206350|Nitrosomonadales U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas k59_273416_1 713587.THITH_02995 8.52e-13 73.2 COG3227@1|root,COG3291@1|root,COG3227@2|Bacteria,COG3291@2|Bacteria 2|Bacteria S metallopeptidase activity - - 3.2.1.18,3.4.11.10 ko:K01186,ko:K05994 ko00511,ko00600,ko04142,map00511,map00600,map04142 - R04018 RC00028,RC00077 ko00000,ko00001,ko01000,ko01002,ko02042 - GH33 - PA,PKD,fn3 k59_1125355_1 525257.HMPREF0204_14310 1.99e-12 72.4 COG1680@1|root,COG1680@2|Bacteria,4NI1Z@976|Bacteroidetes,1HYQF@117743|Flavobacteriia,3ZQY6@59732|Chryseobacterium 976|Bacteroidetes V Beta-lactamase - - - - - - - - - - - - Beta-lactamase,TPR_2 k59_621160_1 454957.IA64_20020 0.00013 46.6 COG1366@1|root,COG1366@2|Bacteria,1PCVS@1224|Proteobacteria,1SCT3@1236|Gammaproteobacteria,1X73U@135614|Xanthomonadales 135614|Xanthomonadales T Belongs to the anti-sigma-factor antagonist family spoIIAA - - - - - - - - - - - STAS,STAS_2 k59_621160_2 1122604.JONR01000009_gene2309 8.08e-10 58.9 COG1235@1|root,COG1235@2|Bacteria,1NW4Z@1224|Proteobacteria,1RPS3@1236|Gammaproteobacteria 1236|Gammaproteobacteria S COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I - - - - - - - - - - - - Lactamase_B_2 k59_571716_1 261292.Nit79A3_3014 4.93e-89 286.0 COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,2VM4W@28216|Betaproteobacteria,372UR@32003|Nitrosomonadales 28216|Betaproteobacteria G PFAM glycosyl transferase, family 35 - - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - DUF3417,Phosphorylase k59_1090062_1 864051.BurJ1DRAFT_4033 3.87e-16 75.5 COG4665@1|root,COG4665@2|Bacteria,1QY3M@1224|Proteobacteria,2VRJ5@28216|Betaproteobacteria 28216|Betaproteobacteria Q Tripartite ATP-independent periplasmic transporters, DctQ component - - - - - - - - - - - - DctQ k59_1090062_2 1131814.JAFO01000001_gene4475 1.56e-52 178.0 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria,3F17M@335928|Xanthobacteraceae 28211|Alphaproteobacteria G Tripartite ATP-independent periplasmic transporter, DctM component - - - - - - - - - - - - DctM k59_1090081_1 195250.CM001776_gene3876 4e-123 363.0 COG0535@1|root,COG0535@2|Bacteria,1G18X@1117|Cyanobacteria,1GZR3@1129|Synechococcus 1117|Cyanobacteria S L-Asparaginase II - - - - - - - - - - - - DUF3641,Fer4_12,Radical_SAM k59_1256233_1 1123487.KB892838_gene3825 2.21e-149 446.0 COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,2VJ5Q@28216|Betaproteobacteria,2KV41@206389|Rhodocyclales 206389|Rhodocyclales L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV ## 4914 queries scanned ## Total time (seconds): 83.1174669265747 ## Rate: 59.12 q/s